format-version: 1.2 data-version: 1.1.2026 date: 09:06:2011 14:16 auto-generated-by: OBO-Edit 2.0 subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" subsetdef: high_level_annotation_qc "High-level terms not to be used for direct annotation" subsetdef: unvetted "unvetted" synonymtypedef: systematic_synonym "Systematic synonym" EXACT default-namespace: gene_ontology remark: cvs version: $Revision: 1.2026 $ ontology: go [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] synonym: "mitochondrial inheritance" EXACT [] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution [Term] id: GO:0000002 name: mitochondrial genome maintenance namespace: biological_process def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GOC:go_curators, GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process [Term] id: GO:0000005 name: ribosomal chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913] comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. is_obsolete: true consider: GO:0042254 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0000006 name: high affinity zinc uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000007 name: low-affinity zinc ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000008 name: thioredoxin namespace: molecular_function alt_id: GO:0000013 def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd] comment: This term was made obsolete because it represents gene products. is_obsolete: true consider: GO:0006467 consider: GO:0015036 [Term] id: GO:0000009 name: alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage." [GOC:mcc, PMID:2644248] xref: EC:2.4.1.- xref: Reactome:20519 "alpha-1,6-mannosyltransferase activity" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000010 name: trans-hexaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate." [EC:2.5.1.30, RHEA:20839] subset: gosubset_prok synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30] xref: EC:2.5.1.30 xref: KEGG:R05612 xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN xref: RHEA:20839 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0000012 name: single strand break repair namespace: biological_process def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0000014 name: single-stranded DNA specific endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] synonym: "ssDNA-specific endodeoxyribonuclease activity" EXACT [GOC:mah] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0000015 name: phosphopyruvate hydratase complex namespace: cellular_component def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "enolase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0000016 name: lactase activity namespace: molecular_function def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108] synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108] synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108] xref: EC:3.2.1.108 xref: MetaCyc:LACTASE-RXN xref: Reactome:20536 "lactase activity" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0000017 name: alpha-glucoside transport namespace: biological_process def: "The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042946 ! glucoside transport [Term] id: GO:0000018 name: regulation of DNA recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolic process relationship: regulates GO:0006310 ! DNA recombination [Term] id: GO:0000019 name: regulation of mitotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] synonym: "regulation of recombination within rDNA repeats" NARROW [] is_a: GO:0000018 ! regulation of DNA recombination relationship: regulates GO:0006312 ! mitotic recombination [Term] id: GO:0000020 name: negative regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it describes a substrate-specific process. is_obsolete: true consider: GO:0045950 [Term] id: GO:0000022 name: mitotic spindle elongation namespace: biological_process def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah] synonym: "spindle elongation during mitosis" EXACT [] is_a: GO:0051231 ! spindle elongation relationship: part_of GO:0007052 ! mitotic spindle organization [Term] id: GO:0000023 name: maltose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "malt sugar metabolic process" EXACT [] synonym: "malt sugar metabolism" EXACT [] synonym: "maltose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0000024 name: maltose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "malt sugar biosynthesis" EXACT [] synonym: "malt sugar biosynthetic process" EXACT [] synonym: "maltose anabolism" EXACT [] synonym: "maltose biosynthesis" EXACT [] synonym: "maltose formation" EXACT [] synonym: "maltose synthesis" EXACT [] is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0000025 name: maltose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "malt sugar catabolic process" EXACT [] synonym: "malt sugar catabolism" EXACT [] synonym: "maltose breakdown" EXACT [] synonym: "maltose degradation" EXACT [] synonym: "maltose hydrolysis" NARROW [] xref: MetaCyc:MALTOSECAT-PWY is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0000026 name: alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage." [GOC:mcc, PMID:10521541] xref: EC:2.4.1.- xref: Reactome:20565 "alpha-1,2-mannosyltransferase activity" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000027 name: ribosomal large subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl] subset: gosubset_prok synonym: "50S ribosomal subunit assembly" NARROW [GOC:mah] synonym: "60S ribosomal subunit assembly" NARROW [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0042255 ! ribosome assembly relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis [Term] id: GO:0000028 name: ribosomal small subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl] subset: gosubset_prok synonym: "30S ribosomal subunit assembly" NARROW [GOC:mah] synonym: "40S ribosomal subunit assembly" NARROW [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0042255 ! ribosome assembly relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis [Term] id: GO:0000030 name: mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok xref: EC:2.4.1.- xref: Reactome:7672 "mannosyltransferase activity" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0000031 name: mannosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0000032 name: cell wall mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues." [GOC:ai] subset: gosubset_prok synonym: "cell wall mannoprotein anabolism" EXACT [] synonym: "cell wall mannoprotein biosynthesis" EXACT [] synonym: "cell wall mannoprotein formation" EXACT [] synonym: "cell wall mannoprotein synthesis" EXACT [] is_a: GO:0006057 ! mannoprotein biosynthetic process is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process [Term] id: GO:0000033 name: alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:mcc, PMID:10521541] xref: EC:2.4.1.- xref: Reactome:20580 "alpha-1,3-mannosyltransferase activity" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000034 name: adenine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] subset: gosubset_prok synonym: "ADase activity" EXACT [EC:3.5.4.2] synonym: "adenase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2] xref: EC:3.5.4.2 xref: MetaCyc:ADENINE-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0000035 name: acyl binding namespace: molecular_function def: "Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [GOC:curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0005488 ! binding [Term] id: GO:0000036 name: acyl carrier activity namespace: molecular_function def: "Enables the directed movement of acyl groups into, out of, within or between cells." [CHEBI:22221, GOC:cb] subset: gosubset_prok is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0000038 name: very long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater." [GOC:hjd] subset: gosubset_prok synonym: "very-long-chain fatty acid metabolic process" EXACT [] synonym: "very-long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0000039 name: plasma membrane long-chain fatty acid transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and it contains component information. is_obsolete: true consider: GO:0005324 consider: GO:0005886 [Term] id: GO:0000040 name: low-affinity iron ion transport namespace: biological_process def: "The directed, low-affinity movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] synonym: "low affinity iron ion transport" EXACT [] is_a: GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0000041 name: transition metal ion transport namespace: biological_process def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "transition metal transport" EXACT [] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0000042 name: protein targeting to Golgi namespace: biological_process def: "The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah] synonym: "protein-Golgi targeting" EXACT [] is_a: GO:0000301 ! retrograde transport, vesicle recycling within Golgi is_a: GO:0006605 ! protein targeting is_a: GO:0072600 ! establishment of protein localization in Golgi [Term] id: GO:0000044 name: ascorbate stabilization namespace: biological_process def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport] comment: This term was made obsolete because it is defined as a function term and is in the process ontology. synonym: "vitamin C stabilization" EXACT [] is_obsolete: true [Term] id: GO:0000045 name: autophagic vacuole assembly namespace: biological_process def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [PMID:9412464] synonym: "autophagic vacuole formation" RELATED [GOC:mah] synonym: "autophagosome biosynthesis" EXACT [] synonym: "autophagosome formation" EXACT [] synonym: "PAS formation" NARROW [] is_a: GO:0007033 ! vacuole organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000046 name: autophagic vacuole fusion namespace: biological_process def: "The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole." [PMID:11099404] synonym: "fusion of autophagosome with lysosome" NARROW [] is_a: GO:0048284 ! organelle fusion is_a: GO:0090174 ! organelle membrane fusion relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000047 name: Rieske iron-sulfur protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "Rieske iron-sulphur protein" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0000048 name: peptidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921] synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12] xref: EC:2.3.2.12 xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN xref: Reactome:20610 "peptidyltransferase activity" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0000049 name: tRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0000050 name: urea cycle namespace: biological_process alt_id: GO:0006594 alt_id: GO:0006871 def: "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ornithine cycle" EXACT [] synonym: "urea biosynthesis" EXACT [] synonym: "urea biosynthetic process" EXACT [] xref: Reactome:1252933 "Urea cycle" xref: Reactome:1279867 "Urea cycle" xref: Reactome:1298781 "Urea cycle" xref: Reactome:1326436 "Urea cycle" xref: Reactome:1352552 "Urea cycle" xref: Reactome:1372777 "Urea cycle" xref: Reactome:1392787 "Urea cycle" xref: Reactome:1417266 "Urea cycle" xref: Reactome:1450355 "Urea cycle" xref: Reactome:1470894 "Urea cycle" xref: Reactome:1482932 "Urea cycle" xref: Reactome:1496722 "Urea cycle" xref: Reactome:1514113 "Urea cycle" xref: Reactome:1520933 "Urea cycle" xref: Reactome:1526683 "Urea cycle" xref: Reactome:1532412 "Urea cycle" xref: Reactome:1535970 "Urea cycle" xref: Reactome:1537975 "Urea cycle" xref: Reactome:1539228 "Urea cycle" xref: Reactome:1540287 "Urea cycle" xref: Reactome:70635 "Urea cycle" xref: Wikipedia:Urea_cycle is_a: GO:0019627 ! urea metabolic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0000051 name: urea cycle intermediate metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. subset: gosubset_prok synonym: "urea cycle intermediate metabolism" EXACT [] is_obsolete: true [Term] id: GO:0000052 name: citrulline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "citrulline metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0000053 name: argininosuccinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "argininosuccinate metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0000054 name: ribosomal subunit export from nucleus namespace: biological_process def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai] synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah] synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb] is_a: GO:0033753 ! establishment of ribosome localization is_a: GO:0051168 ! nuclear export is_a: GO:0071428 ! rRNA-containing ribonucleoprotein complex export from nucleus relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0000055 name: ribosomal large subunit export from nucleus namespace: biological_process alt_id: GO:0000057 def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "50S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "60S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "ribosomal large subunit export from cell nucleus" EXACT [] synonym: "ribosomal large subunit export out of nucleus" EXACT [] synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal large subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000056 name: ribosomal small subunit export from nucleus namespace: biological_process alt_id: GO:0000058 def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "30S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "40S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "ribosomal small subunit export from cell nucleus" EXACT [] synonym: "ribosomal small subunit export out of nucleus" EXACT [] synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal small subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000059 name: protein import into nucleus, docking namespace: biological_process def: "A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex." [GOC:isa_complete, GOC:mah, PMID:14570049, PMID:7878057, PMID:9126736] synonym: "protein docking during protein import into nucleus" EXACT [] synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein docking during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, docking" EXACT [] synonym: "protein-nucleus import, docking" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000060 name: protein import into nucleus, translocation namespace: biological_process def: "A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:14570049, PMID:9126736] comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "protein import into cell nucleus, translocation" EXACT [] synonym: "protein translocation during protein import into nucleus" EXACT [] synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein translocation during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT [] synonym: "protein-nucleus import, translocation" EXACT [] is_a: GO:0006886 ! intracellular protein transport relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000061 name: protein import into nucleus, substrate release namespace: biological_process def: "A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex." [GOC:mah, PMID:14570049, PMID:9126736, PMID:9687515] synonym: "protein import into cell nucleus, substrate release" EXACT [] synonym: "protein substrate release during protein import into nucleus" EXACT [] synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein substrate release during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT [] synonym: "protein-nucleus import, substrate release" EXACT [] is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000062 name: fatty-acyl-CoA binding namespace: molecular_function def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0005504 ! fatty acid binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0000064 name: L-ornithine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "L-ornithine transporter activity" BROAD [] xref: Reactome:20635 "L-ornithine transmembrane transporter activity" is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0000066 name: mitochondrial ornithine transport namespace: biological_process def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion." [GOC:ai] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015822 ! ornithine transport [Term] id: GO:0000067 name: DNA replication and chromosome cycle namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. is_obsolete: true consider: GO:0006260 consider: GO:0007059 consider: GO:0051276 [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai] synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] is_a: GO:0000819 ! sister chromatid segregation relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000072 name: M phase specific microtubule process namespace: biological_process def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah] synonym: "M-phase specific microtubule process" EXACT [] is_a: GO:0007017 ! microtubule-based process relationship: part_of GO:0000279 ! M phase [Term] id: GO:0000073 name: spindle pole body separation namespace: biological_process alt_id: GO:0030475 def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051300 ! spindle pole body organization [Term] id: GO:0000075 name: cell cycle checkpoint namespace: biological_process def: "A cell cycle regulatory process that controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events. A cell cycle checkpoint encompasses detection of an event or biological quality, signal transduction, and effector processes that delay or stop cell cycle progression in response to a defect." [GOC:curators, ISBN:0815316194] xref: Reactome:1252905 "Cell Cycle Checkpoints" xref: Reactome:1279839 "Cell Cycle Checkpoints" xref: Reactome:1298757 "Cell Cycle Checkpoints" xref: Reactome:1326408 "Cell Cycle Checkpoints" xref: Reactome:1352524 "Cell Cycle Checkpoints" xref: Reactome:1372752 "Cell Cycle Checkpoints" xref: Reactome:1392762 "Cell Cycle Checkpoints" xref: Reactome:1417239 "Cell Cycle Checkpoints" xref: Reactome:1450327 "Cell Cycle Checkpoints" xref: Reactome:1470870 "Cell Cycle Checkpoints" xref: Reactome:1482904 "Cell Cycle Checkpoints" xref: Reactome:1496702 "Cell Cycle Checkpoints" xref: Reactome:1514093 "Cell Cycle Checkpoints" xref: Reactome:1520917 "Cell Cycle Checkpoints" xref: Reactome:1526662 "Cell Cycle Checkpoints" xref: Reactome:1532389 "Cell Cycle Checkpoints" xref: Reactome:69620 "Cell Cycle Checkpoints" xref: Wikipedia:Cell_cycle_checkpoint is_a: GO:0071156 ! regulation of cell cycle arrest relationship: regulates GO:0007050 ! cell cycle arrest [Term] id: GO:0000076 name: DNA replication checkpoint namespace: biological_process def: "A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle is_a: GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0000077 name: DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mah, PMID:11891124] synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW [] xref: Wikipedia:DNA_damage_checkpoint xref: Wikipedia:Postreplication_checkpoint is_a: GO:0006974 ! response to DNA damage stimulus is_a: GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0000078 name: cell shape checkpoint namespace: biological_process def: "A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular shaping and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective." [GOC:vw, PMID:14644188] synonym: "cell morphogenesis checkpoint" EXACT [GOC:dph, GOC:vw] is_a: GO:0007093 ! mitotic cell cycle checkpoint [Term] id: GO:0000079 name: regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators] synonym: "regulation of CDK activity" EXACT [] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity [Term] id: GO:0000080 name: G1 phase of mitotic cell cycle namespace: biological_process def: "G1 phase occurring as part of the mitotic cell cycle. G1 phase is the interval between the completion of DNA segregation (mitosis in a mitotic cell cycle) and the beginning of DNA synthesis. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194] xref: Reactome:1252900 "G1 Phase" xref: Reactome:1279834 "G1 Phase" xref: Reactome:1298752 "G1 Phase" xref: Reactome:1326403 "G1 Phase" xref: Reactome:1352519 "G1 Phase" xref: Reactome:1373221 "G1 Phase" xref: Reactome:1393238 "G1 Phase" xref: Reactome:1417234 "G1 Phase" xref: Reactome:1450322 "G1 Phase" xref: Reactome:69236 "G1 Phase" is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000082 name: G1/S transition of mitotic cell cycle namespace: biological_process def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GOC:mah] xref: Reactome:1252886 "G1/S Transition" xref: Reactome:1279820 "G1/S Transition" xref: Reactome:1298749 "G1/S Transition" xref: Reactome:1326389 "G1/S Transition" xref: Reactome:1352505 "G1/S Transition" xref: Reactome:1372738 "G1/S Transition" xref: Reactome:1392746 "G1/S Transition" xref: Reactome:1417220 "G1/S Transition" xref: Reactome:1450308 "G1/S Transition" xref: Reactome:1470855 "G1/S Transition" xref: Reactome:1482889 "G1/S Transition" xref: Reactome:1496686 "G1/S Transition" xref: Reactome:1514077 "G1/S Transition" xref: Reactome:1520902 "G1/S Transition" xref: Reactome:1526646 "G1/S Transition" xref: Reactome:1532373 "G1/S Transition" xref: Reactome:1535945 "G1/S Transition" xref: Reactome:69206 "G1/S Transition" is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000083 name: regulation of transcription involved in G1/S phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1/S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G1/S-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle" RELATED [] synonym: "regulation of transcription involved in G1/S-phase of mitotic cell cycle" EXACT [] xref: Reactome:69205 "G1/S-Specific Transcription" is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0000084 name: S phase of mitotic cell cycle namespace: biological_process def: "S phase occurring as part of the mitotic cell cycle. S phase is the part of the cell cycle during which DNA synthesis takes place. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194] synonym: "S-phase of mitotic cell cycle" EXACT [] xref: Reactome:1252884 "S Phase" xref: Reactome:1279818 "S Phase" xref: Reactome:1298738 "S Phase" xref: Reactome:1326387 "S Phase" xref: Reactome:1352503 "S Phase" xref: Reactome:1372744 "S Phase" xref: Reactome:1392744 "S Phase" xref: Reactome:1417218 "S Phase" xref: Reactome:1450306 "S Phase" xref: Reactome:1470853 "S Phase" xref: Reactome:1482887 "S Phase" xref: Reactome:1496684 "S Phase" xref: Reactome:1514075 "S Phase" xref: Reactome:1520900 "S Phase" xref: Reactome:1526644 "S Phase" xref: Reactome:1532371 "S Phase" xref: Reactome:1535938 "S Phase" xref: Reactome:1539217 "S Phase" xref: Reactome:69242 "S Phase" is_a: GO:0051320 ! S phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000085 name: G2 phase of mitotic cell cycle namespace: biological_process def: "G2 phase occurring as part of the mitotic cell cycle. G2 phase is the interval between the completion of DNA synthesis and the beginning of DNA segregation (mitosis in a mitotic cell cycle). A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194] xref: Reactome:1253420 "G2 Phase" xref: Reactome:1280360 "G2 Phase" xref: Reactome:1299199 "G2 Phase" xref: Reactome:1326938 "G2 Phase" xref: Reactome:1353033 "G2 Phase" xref: Reactome:1417735 "G2 Phase" xref: Reactome:1450834 "G2 Phase" xref: Reactome:1471240 "G2 Phase" xref: Reactome:68911 "G2 Phase" is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000086 name: G2/M transition of mitotic cell cycle namespace: biological_process def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mah] xref: Reactome:1253278 "G2/M Transition" xref: Reactome:1280214 "G2/M Transition" xref: Reactome:1299166 "G2/M Transition" xref: Reactome:1326790 "G2/M Transition" xref: Reactome:1352893 "G2/M Transition" xref: Reactome:1373099 "G2/M Transition" xref: Reactome:1393115 "G2/M Transition" xref: Reactome:1417601 "G2/M Transition" xref: Reactome:1450692 "G2/M Transition" xref: Reactome:1471156 "G2/M Transition" xref: Reactome:1483167 "G2/M Transition" xref: Reactome:1521108 "G2/M Transition" xref: Reactome:1526879 "G2/M Transition" xref: Reactome:1532609 "G2/M Transition" xref: Reactome:69275 "G2/M Transition" is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000087 name: M phase of mitotic cell cycle namespace: biological_process def: "M phase occurring as part of the mitotic cell cycle. M phase is the part of the cell cycle during which nuclear division takes place. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194] synonym: "M-phase of mitotic cell cycle" EXACT [] xref: Reactome:1253276 "M Phase" xref: Reactome:1280212 "M Phase" xref: Reactome:1326788 "M Phase" xref: Reactome:1352891 "M Phase" xref: Reactome:1373097 "M Phase" xref: Reactome:1393113 "M Phase" xref: Reactome:1417599 "M Phase" xref: Reactome:1450690 "M Phase" xref: Reactome:1471154 "M Phase" xref: Reactome:1483157 "M Phase" xref: Reactome:1521111 "M Phase" xref: Reactome:1526883 "M Phase" xref: Reactome:1532603 "M Phase" xref: Reactome:68886 "M Phase" is_a: GO:0000279 ! M phase relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000088 name: mitotic prophase namespace: biological_process def: "Prophase occurring as part of mitosis. Prophase is the part of nuclear division in which, canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:mah, ISBN:0815316194] xref: Reactome:1253311 "Mitotic Prophase" xref: Reactome:1326827 "Mitotic Prophase" xref: Reactome:1352928 "Mitotic Prophase" xref: Reactome:1373133 "Mitotic Prophase" xref: Reactome:1393149 "Mitotic Prophase" xref: Reactome:1417633 "Mitotic Prophase" xref: Reactome:1450733 "Mitotic Prophase" xref: Reactome:1471178 "Mitotic Prophase" xref: Reactome:1483170 "Mitotic Prophase" xref: Reactome:1521117 "Mitotic Prophase" xref: Reactome:1526882 "Mitotic Prophase" xref: Reactome:1532612 "Mitotic Prophase" xref: Reactome:68875 "Mitotic Prophase" is_a: GO:0051324 ! prophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000089 name: mitotic metaphase namespace: biological_process def: "Metaphase occurring as part of mitosis. Metaphase is the part of nuclear division in which, canonically, chromosomes become aligned on the equatorial plate of the cell. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0815316194] xref: Reactome:68879 "Mitotic Metaphase" is_a: GO:0051323 ! metaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000090 name: mitotic anaphase namespace: biological_process def: "Anaphase occurring as part of mitosis. Anaphase is the part of nuclear division in which sister chromatids (or chromosomes) separate and migrate towards the poles of the spindle. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, ISBN:0815316194] xref: Reactome:68882 "Mitotic Anaphase" is_a: GO:0051322 ! anaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000091 name: mitotic anaphase A namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [GOC:dph, GOC:mah, ISBN:0815316194] is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000092 name: mitotic anaphase B namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [GOC:dph, GOC:mah, ISBN:0815316194] is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000093 name: mitotic telophase namespace: biological_process def: "Telophase occurring as part of mitosis. Telophase is the part of nuclear division that, canonically, begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0051326 ! telophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000094 name: septin assembly and septum formation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined and the string name implied two separate processes. is_obsolete: true consider: GO:0000917 consider: GO:0000918 consider: GO:0000921 [Term] id: GO:0000095 name: S-adenosylmethionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015177 def: "Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] synonym: "S-adenosyl methionine permease activity" EXACT [] synonym: "S-adenosyl methionine transporter activity" EXACT [] synonym: "S-adenosylmethionine permease activity" EXACT [] synonym: "S-adenosylmethionine transporter activity" BROAD [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0051185 ! coenzyme transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0000096 name: sulfur amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid metabolism" EXACT [] synonym: "sulphur amino acid metabolic process" EXACT [] synonym: "sulphur amino acid metabolism" EXACT [] xref: Reactome:937250 "Sulfur amino acid metabolism" is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0000097 name: sulfur amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid anabolism" EXACT [] synonym: "sulfur amino acid biosynthesis" EXACT [] synonym: "sulfur amino acid formation" EXACT [] synonym: "sulfur amino acid synthesis" EXACT [] synonym: "sulphur amino acid biosynthesis" EXACT [] synonym: "sulphur amino acid biosynthetic process" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000098 name: sulfur amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid breakdown" EXACT [] synonym: "sulfur amino acid catabolism" EXACT [] synonym: "sulfur amino acid degradation" EXACT [] synonym: "sulphur amino acid catabolic process" EXACT [] synonym: "sulphur amino acid catabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0000099 name: sulfur amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sulfur amino acid transporter activity" BROAD [] synonym: "sulphur amino acid transmembrane transporter activity" EXACT [] synonym: "sulphur amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0000100 name: S-methylmethionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015178 def: "Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "S-methylmethionine permease activity" EXACT [] synonym: "S-methylmethionine transporter activity" BROAD [] is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0000101 name: sulfur amino acid transport namespace: biological_process def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "sulphur amino acid transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0000102 name: L-methionine secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "L-methionine porter activity" RELATED [] is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0015191 ! L-methionine transmembrane transporter activity [Term] id: GO:0000103 name: sulfate assimilation namespace: biological_process alt_id: GO:0019378 def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl] subset: gosubset_prok synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [] synonym: "sulphate assimilation" EXACT [] synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [] xref: Reactome:936635 "Sulfate assimilation" is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0000104 name: succinate dehydrogenase activity namespace: molecular_function alt_id: GO:0019739 def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd] subset: gosubset_prok synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1] synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1] synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1] xref: EC:1.3.99.1 xref: MetaCyc:SUCC-FUM-OXRED-RXN is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0000105 name: histidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "histidine anabolism" EXACT [] synonym: "histidine biosynthesis" EXACT [] synonym: "histidine formation" EXACT [] synonym: "histidine synthesis" EXACT [] xref: MetaCyc:HISTSYN-PWY is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009076 ! histidine family amino acid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process [Term] id: GO:0000107 name: imidazoleglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+." [MetaCyc:GLUTAMIDOTRANS-RXN] subset: gosubset_prok synonym: "glutamine amidotransferase:cyclase activity" BROAD [] synonym: "imidazole glycerol phosphate synthase activity" EXACT [] synonym: "imidazole-glycerol-phosphate synthase activity" RELATED [] synonym: "imidazoleglycerol phosphate synthase activity" EXACT [] xref: EC:2.4.2.- xref: MetaCyc:GLUTAMIDOTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000108 name: repairosome namespace: cellular_component def: "OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] comment: This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators. is_obsolete: true replaced_by: GO:0000109 [Term] id: GO:0000109 name: nucleotide-excision repair complex namespace: cellular_component def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862] comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000110 name: nucleotide-excision repair factor 1 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF1 complex" EXACT [] synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000111 name: nucleotide-excision repair factor 2 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF2 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000112 name: nucleotide-excision repair factor 3 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p)." [PMID:10915862, PMID:14500720, PMID:7813015] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF3 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000113 name: nucleotide-excision repair factor 4 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF4 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000114 name: regulation of transcription involved in G1 phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G1-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle [Term] id: GO:0000115 name: regulation of transcription involved in S phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED [] synonym: "regulation of transcription involved in S-phase of mitotic cell cycle" EXACT [] synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED [] synonym: "S-specific transcription in mitotic cell cycle" EXACT [] xref: Reactome:69241 "S-specific transcription in mitotic cell cycle" is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000084 ! S phase of mitotic cell cycle [Term] id: GO:0000116 name: regulation of transcription involved in G2-phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G2-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000085 ! G2 phase of mitotic cell cycle [Term] id: GO:0000117 name: regulation of transcription involved in G2/M-phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle" RELATED [] xref: Reactome:69274 "G2/M-specific transcription in mitotic cell cycle" is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0000118 name: histone deacetylase complex namespace: cellular_component def: "A protein complex that possesses histone deacetylase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. synonym: "HDAC complex" EXACT [] is_a: GO:0016585 ! chromatin remodeling complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0000120 name: RNA polymerase I transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah] is_a: GO:0005667 ! transcription factor complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0000121 name: glycerol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21] synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21] xref: EC:3.1.3.21 xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0000122 name: negative regulation of transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0010553 alt_id: GO:0045816 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED [] synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "negative regulation of global transcription from Pol II promoter" RELATED [] synonym: "negative regulation of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0000123 name: histone acetyltransferase complex namespace: cellular_component def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "histone acetylase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0000124 name: SAGA complex namespace: cellular_component def: "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012] synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0000125 name: PCAF complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "PCAF histone acetylase-associated complex" EXACT [] synonym: "SPT3-TAF9-PCAF acetylase complex" EXACT [GOC:rl, PMID:18838386] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0000126 name: transcription factor TFIIIB complex namespace: cellular_component def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000127 name: transcription factor TFIIIC complex namespace: cellular_component def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species." [GOC:mah, PMID:11433012] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000128 name: flocculation namespace: biological_process def: "The non-sexual aggregation of single-celled organisms." [GOC:jl] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Flocculation is_a: GO:0051704 ! multi-organism process [Term] id: GO:0000131 name: incipient cellular bud site namespace: cellular_component def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt] is_a: GO:0044424 ! intracellular part [Term] id: GO:0000132 name: establishment of mitotic spindle orientation namespace: biological_process alt_id: GO:0030607 alt_id: GO:0030609 def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] synonym: "establishment of spindle orientation during mitosis" RELATED [GOC:dph, GOC:tb] synonym: "establishment of spindle orientation involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "mitotic spindle orientation" EXACT [] synonym: "orienting of mitotic spindle" EXACT [] is_a: GO:0040001 ! establishment of mitotic spindle localization is_a: GO:0051294 ! establishment of spindle orientation [Term] id: GO:0000133 name: polarisome namespace: cellular_component def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030427 ! site of polarized growth [Term] id: GO:0000135 name: septin checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic cyclin-dependent kinase (CDK). In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642] is_a: GO:0031565 ! cytokinesis checkpoint [Term] id: GO:0000136 name: alpha-1,6-mannosyltransferase complex namespace: cellular_component def: "A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735] is_a: GO:0031501 ! mannosyltransferase complex is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0000137 ! Golgi cis cisterna [Term] id: GO:0000137 name: Golgi cis cisterna namespace: cellular_component def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000138 name: Golgi trans cisterna namespace: cellular_component def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] synonym: "late Golgi" RELATED [GOC:mah] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0000140 name: acylglycerone-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+." [EC:1.1.1.101] synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT [] synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101] synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] xref: EC:1.1.1.101 xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN xref: Reactome:21659 "acylglycerone-phosphate reductase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000142 name: cellular bud neck contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555] synonym: "neck ring" EXACT [] is_a: GO:0005826 ! actomyosin contractile ring relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000144 name: cellular bud neck septin ring namespace: cellular_component def: "A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure [Term] id: GO:0000145 name: exocyst namespace: cellular_component def: "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152] synonym: "Sec6/8 complex" EXACT [] xref: Wikipedia:Exocyst is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part [Term] id: GO:0000146 name: microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] synonym: "actin filament motor activity" EXACT [GOC:dph] synonym: "actin-filament motor activity" EXACT [] synonym: "muscle motor activity" NARROW [] synonym: "myosin ATPase activity" RELATED [] xref: Reactome:10657 "microfilament motor activity" is_a: GO:0003774 ! motor activity [Term] id: GO:0000147 name: actin cortical patch assembly namespace: biological_process def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah] is_a: GO:0030866 ! cortical actin cytoskeleton organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0000148 name: 1,3-beta-D-glucan synthase complex namespace: cellular_component def: "A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a 1,3-beta-D-glucan chain." [EC:2.4.1.34] synonym: "1,3-beta-glucan synthase complex" EXACT [GOC:tb] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0000149 name: SNARE binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] synonym: "SNAP receptor binding" EXACT [] xref: Reactome:15373 "SNARE binding" is_a: GO:0005515 ! protein binding [Term] id: GO:0000150 name: recombinase activity namespace: molecular_function def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. subset: gosubset_prok synonym: "strand transferase" NARROW [] xref: Reactome:21685 "recombinase activity" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000151 name: ubiquitin ligase complex namespace: cellular_component def: "A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000152 name: nuclear ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000153 name: cytoplasmic ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000154 name: rRNA modification namespace: biological_process alt_id: GO:0016548 def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. subset: gosubset_prok synonym: "rRNA editing" NARROW [GOC:hjd] is_a: GO:0006364 ! rRNA processing is_a: GO:0009451 ! RNA modification [Term] id: GO:0000155 name: two-component sensor activity namespace: molecular_function def: "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] subset: gosubset_prok synonym: "two-component sensor molecule" NARROW [] synonym: "two-component system sensor activity " EXACT [] xref: EC:2.7.3.- is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0000156 name: two-component response regulator activity namespace: molecular_function def: "Responds to a two-component sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] subset: gosubset_prok is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0000159 name: protein phosphatase type 2A complex namespace: cellular_component def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000160 name: two-component signal transduction system (phosphorelay) namespace: biological_process def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038] subset: gosubset_prok synonym: "histidyl-aspartyl phosphorelay" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0000161 name: MAPKKK cascade involved in osmosensory signaling pathway namespace: biological_process def: "MAPKKK cascade involved in signal transduction in response to change in osmotic conditions." [PMID:9561267] synonym: "MAPKKK cascade during osmolarity sensing" EXACT [] synonym: "MAPKKK cascade involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, MAPKKK cascade" EXACT [] is_a: GO:0000165 ! MAPKKK cascade relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000162 name: tryptophan biosynthetic process namespace: biological_process alt_id: GO:0009096 def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", MetaCyc:TRPSYN-PWY] subset: gosubset_prok synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT [] synonym: "tryptophan anabolism" EXACT [] synonym: "tryptophan biosynthesis" EXACT [] synonym: "tryptophan formation" EXACT [] synonym: "tryptophan synthesis" EXACT [] xref: MetaCyc:TRPSYN-PWY is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0046219 ! indolalkylamine biosynthetic process [Term] id: GO:0000164 name: protein phosphatase type 1 complex namespace: cellular_component def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000165 name: MAPKKK cascade namespace: biological_process def: "A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK." [GOC:bf, GOC:mtg_signaling_feb11, PMID:9561267] synonym: "ERK/MAPK cascade" EXACT [] synonym: "MAP kinase cascade" EXACT [] synonym: "MAP kinase kinase kinase cascade" EXACT [] synonym: "MAPK cascade" EXACT [] synonym: "MAPK signaling" RELATED [] synonym: "MAPK signalling" RELATED [] synonym: "MAPKKK cascade during sporulation" NARROW [] xref: Reactome:109869 "MAP kinase cascade" xref: Reactome:1253131 "MAP kinase cascade" xref: Reactome:1280065 "MAP kinase cascade" xref: Reactome:1298946 "MAP kinase cascade" xref: Reactome:1326636 "MAP kinase cascade" xref: Reactome:1352748 "MAP kinase cascade" xref: Reactome:1372959 "MAP kinase cascade" xref: Reactome:1392975 "MAP kinase cascade" xref: Reactome:1417455 "MAP kinase cascade" xref: Reactome:1450548 "MAP kinase cascade" xref: Reactome:1471047 "MAP kinase cascade" xref: Reactome:1483063 "MAP kinase cascade" xref: Reactome:1526784 "MAP kinase cascade" xref: Reactome:1532510 "MAP kinase cascade" xref: Wikipedia:MAPK_cascade xref: Wikipedia:Mitogen-activated_protein_kinase is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0000167 name: activation of MAPKKK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKKK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000168 name: activation of MAPKK activity involved in osmosensory signaling pathway namespace: biological_process alt_id: GO:0007233 def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "activation of Pbs2 kinase" NARROW [] synonym: "osmolarity sensing, activation of MAP kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000169 name: activation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267] synonym: "activation of MAPK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000170 name: sphingosine hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] xref: Reactome:21747 "sphingosine hydroxylase activity" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0000171 name: ribonuclease MRP activity namespace: molecular_function def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380] synonym: "RNase MRP" EXACT [] xref: Wikipedia:RNase_MRP is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0000172 name: ribonuclease MRP complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714] synonym: "ribonuclease mitochondrial RNA processing complex" EXACT [] synonym: "RNase MRP complex" EXACT [] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex [Term] id: GO:0000173 name: inactivation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267] synonym: "inactivation of MAPK activity during osmolarity sensing" EXACT [] synonym: "inactivation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, inactivation of MAPK" EXACT [] synonym: "osmolarity sensing, termination of MAPK activity" EXACT [] synonym: "termination of MAPK activity during osmolarity sensing" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000174 name: inactivation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0000175 name: 3'-5'-exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "3'-5' exoribonuclease activity" EXACT [] xref: EC:3.1.13.- xref: Reactome:21755 "3'-5'-exoribonuclease activity" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0000176 name: nuclear exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT [] synonym: "nuclear exosome (ribonuclease complex)" EXACT [] synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000177 name: cytoplasmic exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791] synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT [] synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT [] synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000178 name: exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases." [PMID:10465791] comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. subset: goslim_pir synonym: "exosome (ribonucleasease complex)" EXACT [] synonym: "exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000179 name: rRNA (adenine-N6,N6-)-dimethyltransferase activity namespace: molecular_function alt_id: GO:0043790 def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337 "Modification and Editing of RNA", PMID:10690410] subset: gosubset_prok synonym: "18S rRNA dimethylase activity" EXACT [] synonym: "dimethyladenosine transferase activity" EXACT [IMG:02532] synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [IMG:02532] xref: EC:2.1.1.- is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0000180 name: cytosolic large ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. is_obsolete: true consider: GO:0022625 [Term] id: GO:0000181 name: cytosolic small ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. is_obsolete: true consider: GO:0022627 [Term] id: GO:0000182 name: rDNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah] synonym: "ribosomal DNA binding" EXACT [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0000183 name: chromatin silencing at rDNA namespace: biological_process def: "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245] synonym: "chromatin silencing at ribosomal DNA" EXACT [] synonym: "heterochromatic silencing at rDNA" EXACT [] synonym: "rDNA chromatin silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0000184 name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] synonym: "mRNA breakdown, nonsense-mediated decay" EXACT [] synonym: "mRNA catabolic process, nonsense-mediated" EXACT [] synonym: "mRNA catabolism, nonsense-mediated" EXACT [] synonym: "mRNA degradation, nonsense-mediated decay" EXACT [] synonym: "nonsense-mediated mRNA decay" EXACT [] synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [] xref: Wikipedia:Nonsense-mediated_decay xref: Wikipedia:Nonsense-mediated_mRNA_decay is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000185 name: activation of MAPKKK activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase" EXACT [] synonym: "activation of MAPKKK activity during sporulation" NARROW [] synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD [] synonym: "positive regulation of MAPKKK activity" BROAD [] is_a: GO:0032147 ! activation of protein kinase activity relationship: part_of GO:0043410 ! positive regulation of MAPKKK cascade [Term] id: GO:0000186 name: activation of MAPKK activity namespace: biological_process alt_id: GO:0007255 def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK." [PMID:9561267] synonym: "activation of MAP kinase kinase activity" EXACT [] synonym: "activation of MAP/ERK kinase kinase" EXACT [] synonym: "activation of MAPKK activity during sporulation" NARROW [] synonym: "positive regulation of MAPKK activity" BROAD [] xref: Reactome:110049 "MEK activation" xref: Reactome:1253130 "MEK activation" xref: Reactome:1253133 "Prolonged ERK activation events" xref: Reactome:1280064 "MEK activation" xref: Reactome:1280067 "Prolonged ERK activation events" xref: Reactome:1298948 "Prolonged ERK activation events" xref: Reactome:1326635 "MEK activation" xref: Reactome:1326638 "Prolonged ERK activation events" xref: Reactome:1352747 "MEK activation" xref: Reactome:1352750 "Prolonged ERK activation events" xref: Reactome:1372958 "MEK activation" xref: Reactome:1372961 "Prolonged ERK activation events" xref: Reactome:1392974 "MEK activation" xref: Reactome:1392977 "Prolonged ERK activation events" xref: Reactome:1417454 "MEK activation" xref: Reactome:1417457 "Prolonged ERK activation events" xref: Reactome:1450547 "MEK activation" xref: Reactome:1450550 "Prolonged ERK activation events" xref: Reactome:1471054 "Prolonged ERK activation events" xref: Reactome:1483070 "Prolonged ERK activation events" xref: Reactome:1526793 "Prolonged ERK activation events" xref: Reactome:1532519 "Prolonged ERK activation events" xref: Reactome:169893 "Prolonged ERK activation events" is_a: GO:0006468 ! protein phosphorylation is_a: GO:0032147 ! activation of protein kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000187 name: activation of MAPK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [PMID:9561267] synonym: "activation of MAP kinase" EXACT [] synonym: "activation of MAPK activity during sporulation" NARROW [] synonym: "MAPK activation" EXACT [] xref: Reactome:112409 "ERK activation" xref: Reactome:1253140 "ERK activation" xref: Reactome:1253775 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1280074 "ERK activation" xref: Reactome:1280708 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1298945 "ERK activation" xref: Reactome:1299531 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1326645 "ERK activation" xref: Reactome:1327292 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1352757 "ERK activation" xref: Reactome:1353391 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1372968 "ERK activation" xref: Reactome:1373563 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1392984 "ERK activation" xref: Reactome:1393579 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1417464 "ERK activation" xref: Reactome:1418084 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1450557 "ERK activation" xref: Reactome:1451175 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1471046 "ERK activation" xref: Reactome:1471518 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1483062 "ERK activation" xref: Reactome:1483458 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1497097 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1514484 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1521351 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1526783 "ERK activation" xref: Reactome:1527048 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:1532509 "ERK activation" xref: Reactome:1532780 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:437980 "Activated TAK1 mediates p38 MAP kinase phosphorylation" xref: Reactome:450302 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:451524 "MAPK activation in TLR cascade" is_a: GO:0006468 ! protein phosphorylation is_a: GO:0043406 ! positive regulation of MAP kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000188 name: inactivation of MAPK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267] synonym: "inactivation of MAPK during sporulation" NARROW [] synonym: "termination of MAPK activity" EXACT [] is_a: GO:0043407 ! negative regulation of MAP kinase activity relationship: part_of GO:0043409 ! negative regulation of MAPKKK cascade [Term] id: GO:0000189 name: MAPK import into nucleus namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267] comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "nuclear translocation of MAPK" NARROW [GOC:mah] xref: Reactome:109867 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:109868 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:112353 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1230753 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:1230758 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1258553 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:1258559 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1284036 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1304488 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:1304491 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1356754 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1377756 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1398085 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1424424 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:1424431 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1456304 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:1456307 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1475144 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:1475147 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1523980 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:1523985 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:1529687 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:1529690 "Nuclear translocation of phospho-ERK-2 dimer" is_a: GO:0006606 ! protein import into nucleus relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000190 name: MAPKKK cascade (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000191 name: activation of MAPKKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000192 name: activation of MAPKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000193 name: activation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000194 name: inactivation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000195 name: nuclear translocation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000196 name: MAPKKK cascade involved in cell wall biogenesis namespace: biological_process def: "A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "cell wall biogenesis, MAPKKK cascade" EXACT [] is_a: GO:0000165 ! MAPKKK cascade relationship: part_of GO:0042546 ! cell wall biogenesis [Term] id: GO:0000197 name: activation of MAPKKK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000198 name: activation of MAPKK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000199 name: activation of MAPK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000200 name: inactivation of MAPK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT [] synonym: "cell wall biogenesis, termination of MAPK activity" EXACT [] synonym: "inactivation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "termination of MAPK activity during cell wall biogenesis" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000201 name: MAPK import into nucleus involved in cell wall biogenesis namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "cell wall biogenesis, MAPK import into nucleus" EXACT [GOC:mah] synonym: "cell wall biogenesis, nuclear translocation of MAPK" NARROW [GOC:mah] synonym: "MAPK import into nucleus involved in cell wall integrity" EXACT [GOC:dgf, GOC:mah] synonym: "nuclear translocation of MAPK involved in cell wall biogenesis" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in cell wall integrity" NARROW [GOC:dgf, GOC:mah] is_a: GO:0000189 ! MAPK import into nucleus relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000202 name: MAPKKK cascade during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000203 name: activation of MAPKKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000204 name: activation of MAPKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000205 name: activation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000206 name: inactivation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000207 name: nuclear translocation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000208 name: MAPK import into nucleus involved in osmosensory signaling pathway namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267] synonym: "MAPK import into nucleus during osmolarity sensing" EXACT [GOC:mah] synonym: "MAPK import into nucleus involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT [] synonym: "nuclear translocation of MAPK involved in osmosensory signaling pathway" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in osmosensory signalling pathway" NARROW [GOC:mah] synonym: "osmolarity sensing, MAPK import into nucleus" EXACT [GOC:mah] synonym: "osmolarity sensing, nuclear translocation of MAPK" NARROW [GOC:mah] is_a: GO:0000189 ! MAPK import into nucleus relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000209 name: protein polyubiquitination namespace: biological_process def: "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194] synonym: "polyubiquitin" RELATED [] synonym: "protein polyubiquitinylation" EXACT [] synonym: "protein polyubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0000210 name: NAD+ diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] subset: gosubset_prok synonym: "NAD diphosphatase activity" EXACT [] synonym: "NAD pyrophosphatase activity" EXACT [] synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NADH pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "NADP pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22] xref: EC:3.6.1.22 xref: MetaCyc:NADPYROPHOSPHAT-RXN is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0000211 name: protein degradation tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194] comment: This term was made obsolete because it represents a biological process and a molecular function. is_obsolete: true consider: GO:0005515 consider: GO:0019941 consider: GO:0042787 [Term] id: GO:0000212 name: meiotic spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] synonym: "meiotic spindle organisation" EXACT [GOC:curators] synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle organization during meiosis" EXACT [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000213 name: tRNA-intron endonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA-intron endoribonuclease activity" EXACT [] synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9] xref: EC:3.1.27.9 xref: MetaCyc:3.1.27.9-RXN is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0000214 name: tRNA-intron endonuclease complex namespace: cellular_component def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000215 name: tRNA 2'-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "Tpt1" RELATED [EC:2.7.1.160] synonym: "Tpt1p" RELATED [EC:2.7.1.160] synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] xref: EC:2.7.1.160 xref: MetaCyc:2.7.1.160-RXN is_a: GO:0008665 ! 2'-phosphotransferase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0000216 name: M/G1 transition of mitotic cell cycle namespace: biological_process def: "Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah] xref: Reactome:1252874 "M/G1 Transition" xref: Reactome:1279808 "M/G1 Transition" xref: Reactome:1298727 "M/G1 Transition" xref: Reactome:1326377 "M/G1 Transition" xref: Reactome:1352493 "M/G1 Transition" xref: Reactome:1372730 "M/G1 Transition" xref: Reactome:1392734 "M/G1 Transition" xref: Reactome:1417208 "M/G1 Transition" xref: Reactome:1450296 "M/G1 Transition" xref: Reactome:1470843 "M/G1 Transition" xref: Reactome:1482879 "M/G1 Transition" xref: Reactome:1496675 "M/G1 Transition" xref: Reactome:1514066 "M/G1 Transition" xref: Reactome:1520891 "M/G1 Transition" xref: Reactome:1526636 "M/G1 Transition" xref: Reactome:1532362 "M/G1 Transition" xref: Reactome:1535943 "M/G1 Transition" xref: Reactome:68874 "M/G1 Transition" is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000217 name: DNA secondary structure binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0000219 name: vacuolar hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "V-ATPase" EXACT [] is_obsolete: true consider: GO:0016469 [Term] id: GO:0000220 name: vacuolar proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex [Term] id: GO:0000221 name: vacuolar proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain generally consists of eight subunits. synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex [Term] id: GO:0000222 name: plasma membrane proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000223 name: plasma membrane proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000224 name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] subset: gosubset_prok synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52] synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52] synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52] synonym: "N-glycanase activity" RELATED [EC:3.5.1.52] synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52] synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52] synonym: "peptide:N-glycanase" RELATED [] synonym: "PNGase" EXACT [] synonym: "PNGase A" RELATED [EC:3.5.1.52] synonym: "PNGase F" RELATED [EC:3.5.1.52] xref: EC:3.5.1.52 xref: MetaCyc:3.5.1.52-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0000225 name: N-acetylglucosaminylphosphatidylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane." [EC:3.5.1.89] comment: Note that this function was formerly EC:3.1.1.69. synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89] synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89] xref: EC:3.5.1.89 xref: MetaCyc:3.1.1.69-RXN xref: Reactome:22619 "N-acetylglucosaminylphosphatidylinositol deacetylase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0000227 name: oxaloacetate secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "oxaloacetate carrier activity" RELATED [] is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah] subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000229 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "cytoplasmic interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000230 name: nuclear mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000794 [Term] id: GO:0000231 name: cytoplasmic mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000793 [Term] id: GO:0000232 name: nuclear interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000228 [Term] id: GO:0000233 name: cytoplasmic interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000229 [Term] id: GO:0000234 name: phosphoethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103] synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103] xref: EC:2.1.1.103 xref: KEGG:R02037 xref: MetaCyc:2.1.1.103-RXN xref: RHEA:20366 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000235 name: astral microtubule namespace: cellular_component def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] is_a: GO:0005876 ! spindle microtubule is_a: GO:0005881 ! cytoplasmic microtubule relationship: part_of GO:0005818 ! aster [Term] id: GO:0000236 name: mitotic prometaphase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Reactome:1253320 "Mitotic Prometaphase" xref: Reactome:1280258 "Mitotic Prometaphase" xref: Reactome:1326836 "Mitotic Prometaphase" xref: Reactome:1352933 "Mitotic Prometaphase" xref: Reactome:1417641 "Mitotic Prometaphase" xref: Reactome:1450738 "Mitotic Prometaphase" xref: Reactome:1471183 "Mitotic Prometaphase" xref: Reactome:1483175 "Mitotic Prometaphase" xref: Reactome:1521126 "Mitotic Prometaphase" xref: Reactome:68877 "Mitotic Prometaphase" is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000237 name: leptotene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the first stage of prophase I in meiosis, in which chromosomes first become visible." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Leptotene xref: Wikipedia:Meiosis#Leptotene is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000238 name: zygotene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Meiosis#Zygotene xref: Wikipedia:Zygotene is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000239 name: pachytene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Meiosis#Pachytene xref: Wikipedia:Pachytene is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000240 name: diplotene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Diplotene xref: Wikipedia:Meiosis#Diplotene is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000241 name: diakinesis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Diakinesis xref: Wikipedia:Meiosis#Diakinesis is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000242 name: pericentriolar material namespace: cellular_component def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0000243 name: commitment complex namespace: cellular_component def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140] synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah] synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex [Term] id: GO:0000244 name: assembly of spliceosomal tri-snRNP namespace: biological_process alt_id: GO:0000351 alt_id: GO:0000355 def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384] synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW [] synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW [] synonym: "snRNP recycling" BROAD [] synonym: "spliceosomal tri-snRNP assembly" EXACT [] synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW [] synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000387 ! spliceosomal snRNP assembly [Term] id: GO:0000245 name: spliceosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000246 name: delta24(24-1) sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH." [EC:1.3.1.71, RHEA:18504] subset: gosubset_prok synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "D24(24-1)-sterol reductase activity" EXACT [] synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta-24(28) methylene reductase activity" EXACT [] synonym: "sterol delta-24(28) reductase activity" EXACT [] synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71] xref: EC:1.3.1.71 xref: KEGG:R05641 xref: MetaCyc:1.3.1.71-RXN xref: RHEA:18504 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0000247 name: C-8 sterol isomerase activity namespace: molecular_function def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [MetaCyc:RXN3O-203, PMID:8988026] synonym: "delta-8-delta-7 sterol isomerase activity" EXACT [] xref: EC:5.3.3.- is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0000248 name: C-5 sterol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] synonym: "sterol-C5-desaturase activity" EXACT [] xref: Reactome:22657 "C-5 sterol desaturase activity" is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000249 name: C-22 sterol desaturase activity namespace: molecular_function def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000250 name: lanosterol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7, RHEA:14624] subset: gosubset_prok synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT [] synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7] synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7] synonym: "OSC" EXACT [] synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "oxidosqualene-lanosterol cyclase activity" EXACT [] synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581] synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7] synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7] xref: EC:5.4.99.7 xref: KEGG:R03199 xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN xref: Reactome:22668 "lanosterol synthase activity" xref: RHEA:14624 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0000252 name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT [] synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [] synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED [] synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED [] synonym: "C-3 sterol dehydrogenase activity" RELATED [] synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED [] synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [] synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED [] xref: EC:1.1.1.- xref: Reactome:22670 "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000253 name: 3-keto sterol reductase activity namespace: molecular_function alt_id: GO:0050576 def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+." [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3-keto-steroid reductase activity" EXACT [] synonym: "3-KSR activity" EXACT [EC:1.1.1.270] synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] xref: EC:1.1.1.270 xref: MetaCyc:1.1.1.270-RXN xref: MetaCyc:RXN3O-4110 xref: MetaCyc:RXN66-19 xref: MetaCyc:RXN66-24 xref: MetaCyc:RXN66-314 xref: MetaCyc:RXN66-319 xref: Reactome:22671 "3-keto sterol reductase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000254 name: C-4 methylsterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4-methylsterol oxidase activity" EXACT [] synonym: "methylsterol hydroxylase activity" RELATED [] synonym: "methylsterol monooxygenase activity" RELATED [] xref: EC:1.14.13.72 xref: MetaCyc:1.14.13.72-RXN xref: Reactome:22672 "C-4 methylsterol oxidase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0000255 name: allantoin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "allantoin metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0000256 name: allantoin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "allantoin breakdown" EXACT [] synonym: "allantoin catabolism" EXACT [] synonym: "allantoin degradation" EXACT [] is_a: GO:0000255 ! allantoin metabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0000257 name: nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] subset: gosubset_prok synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1] synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1] synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1] xref: EC:3.5.5.1 xref: MetaCyc:3.5.5.1-RXN xref: UM-BBD_enzymeID:e0283 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0000258 name: isoleucine/valine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005283 consider: GO:0005304 consider: GO:0015188 [Term] id: GO:0000259 name: intracellular nucleoside transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai] comment: This term was made obsolete because it contains component and function information. is_obsolete: true replaced_by: GO:0005337 replaced_by: GO:0005622 [Term] id: GO:0000260 name: hydrogen-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0046961 [Term] id: GO:0000261 name: sodium-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0046962 [Term] id: GO:0000262 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] synonym: "mitochondrial DNA" NARROW [] synonym: "mitochondrial genome" RELATED [] synonym: "mtDNA" NARROW [] xref: NIF_Subcellular:sao1186327184 is_a: GO:0000229 ! cytoplasmic chromosome is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0042645 ! mitochondrial nucleoid [Term] id: GO:0000263 name: heterotrimeric G-protein GTPase, alpha-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000264 name: heterotrimeric G-protein GTPase, beta-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000265 name: heterotrimeric G-protein GTPase, gamma-subunit namespace: molecular_function def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] synonym: "mitochondrial division" EXACT [] synonym: "mitochondrial proliferation" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048285 ! organelle fission [Term] id: GO:0000267 name: cell fraction namespace: cellular_component def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: goslim_pir subset: gosubset_prok is_a: GO:0044464 ! cell part [Term] id: GO:0000268 name: peroxisome targeting sequence binding namespace: molecular_function alt_id: GO:0005051 def: "Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568] synonym: "peroxisome targeting signal receptor" NARROW [] synonym: "PTS binding" EXACT [] synonym: "PTS receptor" NARROW [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0000269 name: toxin export channel activity namespace: molecular_function def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0015288 ! porin activity is_a: GO:0019534 ! toxin transporter activity [Term] id: GO:0000270 name: peptidoglycan metabolic process namespace: biological_process alt_id: GO:0009284 def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "murein metabolic process" EXACT [] synonym: "murein metabolism" EXACT [] synonym: "peptidoglycan metabolism" EXACT [] is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] subset: gosubset_prok synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] subset: gosubset_prok synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0000274 name: mitochondrial proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0000275 name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000276 name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000277 name: [cytochrome c]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59] synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59] xref: EC:2.1.1.59 xref: MetaCyc:2.1.1.59-RXN is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] xref: Reactome:1252876 "Cell Cycle, Mitotic" xref: Reactome:1279810 "Cell Cycle, Mitotic" xref: Reactome:1298729 "Cell Cycle, Mitotic" xref: Reactome:1326379 "Cell Cycle, Mitotic" xref: Reactome:1352495 "Cell Cycle, Mitotic" xref: Reactome:1372732 "Cell Cycle, Mitotic" xref: Reactome:1392736 "Cell Cycle, Mitotic" xref: Reactome:1417210 "Cell Cycle, Mitotic" xref: Reactome:1450298 "Cell Cycle, Mitotic" xref: Reactome:1470845 "Cell Cycle, Mitotic" xref: Reactome:1482881 "Cell Cycle, Mitotic" xref: Reactome:1496677 "Cell Cycle, Mitotic" xref: Reactome:1514068 "Cell Cycle, Mitotic" xref: Reactome:1520893 "Cell Cycle, Mitotic" xref: Reactome:1526638 "Cell Cycle, Mitotic" xref: Reactome:1532364 "Cell Cycle, Mitotic" xref: Reactome:1535939 "Cell Cycle, Mitotic" xref: Reactome:1539218 "Cell Cycle, Mitotic" xref: Reactome:69278 "Cell Cycle, Mitotic" is_a: GO:0007049 ! cell cycle [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division." [GOC:dph, GOC:mah, ISBN:0815316194] synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission [Term] id: GO:0000281 name: cytokinesis after mitosis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai] is_a: GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000282 name: cellular bud site selection namespace: biological_process def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010). synonym: "bud site selection/establishment of cell polarity" BROAD [] is_a: GO:0007105 ! cytokinesis, site selection is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000284 name: shmoo orientation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. is_obsolete: true replaced_by: GO:0000753 [Term] id: GO:0000285 name: 1-phosphatidylinositol-3-phosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT [] synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150] xref: EC:2.7.1.150 xref: KEGG:R05802 xref: MetaCyc:2.7.1.150-RXN xref: RHEA:13612 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0000286 name: alanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+." [EC:1.4.1.1] subset: gosubset_prok synonym: "AlaDH" RELATED [EC:1.4.1.1] synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1] synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1] synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] xref: EC:1.4.1.1 xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0000287 name: magnesium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] subset: gosubset_prok synonym: "magnesium binding" EXACT [] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0000288 name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay namespace: biological_process def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc] synonym: "deadenylation-dependent mRNA decay" EXACT [] synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT [] synonym: "mRNA catabolic process, deadenylation-dependent" EXACT [] synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylylation-dependent" EXACT [] synonym: "mRNA degradation, deadenylation-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [] xref: Reactome:1253757 "Deadenylation-dependent mRNA decay" xref: Reactome:1280689 "Deadenylation-dependent mRNA decay" xref: Reactome:1299515 "Deadenylation-dependent mRNA decay" xref: Reactome:1327274 "Deadenylation-dependent mRNA decay" xref: Reactome:1353370 "Deadenylation-dependent mRNA decay" xref: Reactome:1373543 "Deadenylation-dependent mRNA decay" xref: Reactome:1393562 "Deadenylation-dependent mRNA decay" xref: Reactome:1418064 "Deadenylation-dependent mRNA decay" xref: Reactome:1451155 "Deadenylation-dependent mRNA decay" xref: Reactome:1471501 "Deadenylation-dependent mRNA decay" xref: Reactome:1483437 "Deadenylation-dependent mRNA decay" xref: Reactome:1497081 "Deadenylation-dependent mRNA decay" xref: Reactome:1514468 "Deadenylation-dependent mRNA decay" xref: Reactome:1521339 "Deadenylation-dependent mRNA decay" xref: Reactome:1527037 "Deadenylation-dependent mRNA decay" xref: Reactome:1532770 "Deadenylation-dependent mRNA decay" xref: Reactome:1536148 "Deadenylation-dependent mRNA decay" xref: Reactome:429914 "Deadenylation-dependent mRNA decay" is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000289 name: nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc] synonym: "3' to 5' mRNA deadenylation" RELATED [] synonym: "mRNA deadenylation" RELATED [] synonym: "nuclear mRNA poly(A) tail shortening" RELATED [] xref: Reactome:1253759 "Deadenylation of mRNA" xref: Reactome:1280692 "Deadenylation of mRNA" xref: Reactome:1327273 "Deadenylation of mRNA" xref: Reactome:1353373 "Deadenylation of mRNA" xref: Reactome:1393565 "Deadenylation of mRNA" xref: Reactome:1418067 "Deadenylation of mRNA" xref: Reactome:1451157 "Deadenylation of mRNA" xref: Reactome:429947 "Deadenylation of mRNA" is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process is_a: GO:0031124 ! mRNA 3'-end processing relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000290 name: deadenylation-dependent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc] synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT [] synonym: "deadenylylation-dependent decapping" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000291 name: nuclear-transcribed mRNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc] synonym: "exonucleolytic degradation of mRNA" EXACT [] synonym: "mRNA breakdown, exonucleolytic" EXACT [] synonym: "mRNA degradation, exonucleolytic" EXACT [] synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000292 name: RNA fragment catabolic process namespace: biological_process alt_id: GO:0030452 def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah] subset: gosubset_prok synonym: "group I intron catabolic process" NARROW [] synonym: "RNA fragment breakdown" EXACT [] synonym: "RNA fragment catabolism" EXACT [GOC:mah] synonym: "RNA fragment degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0000293 name: ferric-chelate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H+." [EC:1.16.1.7] comment: Note that this function was formerly EC:1.6.99.13. synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7] synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7] synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7] xref: EC:1.16.1.7 xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0000294 name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay namespace: biological_process def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc] synonym: "endonucleolytic mRNA decay" EXACT [] synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "mRNA catabolic process, endonucleolytic" EXACT [] synonym: "mRNA catabolism, endonucleolytic" EXACT [] synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000295 name: adenine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other." [PMID:11566870] xref: Reactome:22791 "adenine nucleotide transmembrane transporter activity" is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity [Term] id: GO:0000296 name: spermine transport namespace: biological_process def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015846 ! polyamine transport [Term] id: GO:0000297 name: spermine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai] is_a: GO:0015203 ! polyamine transmembrane transporter activity [Term] id: GO:0000298 name: endopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10] synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10] xref: EC:3.6.1.10 xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000299 name: integral to membrane of membrane fraction namespace: cellular_component def: "Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. is_a: GO:0005624 ! membrane fraction [Term] id: GO:0000300 name: peripheral to membrane of membrane fraction namespace: cellular_component def: "Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. is_a: GO:0005624 ! membrane fraction [Term] id: GO:0000301 name: retrograde transport, vesicle recycling within Golgi namespace: biological_process def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363] synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT [] is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport [Term] id: GO:0000302 name: response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] subset: gosubset_prok synonym: "response to active oxygen species" EXACT [] synonym: "response to AOS" EXACT [] synonym: "response to reactive oxidative species" EXACT [] synonym: "response to reactive oxygen intermediate" EXACT [] synonym: "response to ROI" EXACT [] synonym: "response to ROS" EXACT [] is_a: GO:0006979 ! response to oxidative stress is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0000303 name: response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0000305 ! response to oxygen radical [Term] id: GO:0000304 name: response to singlet oxygen namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species [Term] id: GO:0000305 name: response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species [Term] id: GO:0000306 name: extrinsic to vacuolar membrane namespace: cellular_component def: "Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0000307 name: cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] subset: goslim_pir synonym: "CDK holoenzyme" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000308 name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000309 name: nicotinamide-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] subset: gosubset_prok synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1] synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1] synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1] synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1] synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1] synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMNAT activity" NARROW [EC:2.7.7.1] xref: EC:2.7.7.1 xref: MetaCyc:2.7.7.1-RXN xref: Reactome:23250 "nicotinamide-nucleotide adenylyltransferase activity" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0000310 name: xanthine phosphoribosyltransferase activity namespace: molecular_function alt_id: GO:0009043 def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate." [EC:2.4.2.22, GOC:clt] subset: gosubset_prok synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT [] synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] xref: EC:2.4.2.22 xref: MetaCyc:XANPRIBOSYLTRAN-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000311 name: plastid large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0000315 ! organellar large ribosomal subunit is_a: GO:0044435 ! plastid part relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000312 name: plastid small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc] is_a: GO:0000314 ! organellar small ribosomal subunit is_a: GO:0044435 ! plastid part relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome is_a: GO:0044422 ! organelle part [Term] id: GO:0000314 name: organellar small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc] is_a: GO:0015935 ! small ribosomal subunit relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000315 name: organellar large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0015934 ! large ribosomal subunit relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000316 name: sulfite transport namespace: biological_process def: "The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sulphite transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0000318 name: protein-methionine-R-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.-, PMID:11929995] subset: gosubset_prok xref: EC:1.8.4.- is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0000319 name: sulfite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfite ions from one side of a membrane to the other." [GOC:as] synonym: "sulphite transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0000320 name: re-entry into mitotic cell cycle namespace: biological_process def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0000321 name: re-entry into mitotic cell cycle after pheromone arrest namespace: biological_process def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449] is_a: GO:0000320 ! re-entry into mitotic cell cycle is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000322 name: storage vacuole namespace: cellular_component def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000324 name: fungal-type vacuole namespace: cellular_component def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649] synonym: "vacuole, cell cycle-correlated morphology" EXACT [] is_a: GO:0000322 ! storage vacuole is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0000325 name: plant-type vacuole namespace: cellular_component def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208] synonym: "vacuole, cell cycle-independent morphology" EXACT [] is_a: GO:0005773 ! vacuole [Term] id: GO:0000326 name: protein storage vacuole namespace: cellular_component def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409] is_a: GO:0000322 ! storage vacuole is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0000327 name: lytic vacuole within protein storage vacuole namespace: cellular_component def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490] is_a: GO:0000323 ! lytic vacuole is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0000326 ! protein storage vacuole [Term] id: GO:0000328 name: fungal-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000329 name: fungal-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "fungal-type vacuolar membrane" RELATED [] synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000330 name: plant-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000325 ! plant-type vacuole [Term] id: GO:0000331 name: contractile vacuole namespace: cellular_component def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, PMID:10503189] xref: Wikipedia:Contractile_vacuole is_a: GO:0005773 ! vacuole is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0000332 name: template for synthesis of G-rich strand of telomere DNA activity namespace: molecular_function def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242] comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins. synonym: "telomerase RNA" EXACT [] synonym: "telomerase, template" EXACT [] is_a: GO:0000497 ! base pairing with DNA relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0000333 name: telomerase catalytic core complex namespace: cellular_component def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [PMID:11884619] is_a: GO:0005697 ! telomerase holoenzyme complex [Term] id: GO:0000334 name: 3-hydroxyanthranilate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.6, RHEA:17956] subset: gosubset_prok synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3HAO" RELATED [EC:1.13.11.6] xref: EC:1.13.11.6 xref: KEGG:R02665 xref: MetaCyc:1.13.11.6-RXN xref: Reactome:23302 "3-hydroxyanthranilate 3,4-dioxygenase activity" xref: RHEA:17956 xref: UM-BBD_reactionID:r1027 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0000335 name: negative regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb] subset: gosubset_prok synonym: "down regulation of DNA transposition" EXACT [] synonym: "down-regulation of DNA transposition" EXACT [] synonym: "downregulation of DNA transposition" EXACT [] synonym: "inhibition of DNA transposition" NARROW [] synonym: "negative regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010529 ! negative regulation of transposition is_a: GO:0045910 ! negative regulation of DNA recombination relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000336 name: positive regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc] subset: gosubset_prok synonym: "activation of DNA transposition" NARROW [] synonym: "positive regulation of DNA transposition" EXACT [GOC:dph] synonym: "stimulation of DNA transposition" NARROW [] synonym: "up regulation of DNA transposition" EXACT [] synonym: "up-regulation of DNA transposition" EXACT [] synonym: "upregulation of DNA transposition" EXACT [] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010530 ! positive regulation of transposition is_a: GO:0045911 ! positive regulation of DNA recombination relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000337 name: regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc] subset: gosubset_prok synonym: "regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0010528 ! regulation of transposition relationship: regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000338 name: protein deneddylation namespace: biological_process def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc] is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0000339 name: RNA cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc] synonym: "binding to mRNA cap" NARROW [] synonym: "mRNA cap binding" NARROW [] synonym: "snRNA cap binding" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0000340 name: RNA 7-methylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc] synonym: "RNA m7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000341 name: RNA trimethylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc] synonym: "RNA m2,2,7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000342 name: RNA cap 4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000343 name: plastid-encoded plastid RNA polymerase complex A namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105] synonym: "PEP-A" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000344 name: plastid-encoded plastid RNA polymerase complex B namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105] synonym: "PEP-B" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000345 name: cytosolic DNA-directed RNA polymerase complex namespace: cellular_component def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566] subset: gosubset_prok is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0000346 name: transcription export complex namespace: cellular_component def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277] subset: goslim_pir synonym: "TREX complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000347 name: THO complex namespace: cellular_component def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000348 name: nuclear mRNA branch site recognition namespace: biological_process alt_id: GO:0000370 alt_id: GO:0000371 def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian). synonym: "spliceosomal A complex biosynthesis" NARROW [] synonym: "spliceosomal A complex formation" NARROW [] synonym: "spliceosomal B complex biosynthesis" NARROW [] synonym: "spliceosomal B complex formation" NARROW [] synonym: "U12-type nuclear mRNA branch site recognition" NARROW [] synonym: "U2-type nuclear mRNA branch site recognition" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosome assembly [Term] id: GO:0000349 name: generation of catalytic spliceosome for first transesterification step namespace: biological_process alt_id: GO:0000356 alt_id: GO:0000357 def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian). synonym: "catalytic spliceosome assembly for first transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for first transesterification step" EXACT [] synonym: "spliceosomal A2-2 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-2 complex formation" NARROW [] synonym: "spliceosomal C1 complex biosynthesis" NARROW [] synonym: "spliceosomal C1 complex formation" NARROW [] synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW [] synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000350 name: generation of catalytic spliceosome for second transesterification step namespace: biological_process alt_id: GO:0000358 alt_id: GO:0000359 def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian). synonym: "catalytic spliceosome assembly for second transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for second transesterification step" EXACT [] synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW [] synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW [] synonym: "formation of spliceosomal A2-2 complex" NARROW [] synonym: "formation of spliceosomal C1 complex" NARROW [] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] synonym: "spliceosomal A2-3 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-3 complex formation" NARROW [] synonym: "spliceosomal C2 complex biosynthesis" NARROW [] synonym: "spliceosomal C2 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000352 name: trans assembly of SL-containing precatalytic spliceosome namespace: biological_process def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosome assembly relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition [Term] id: GO:0000353 name: formation of quadruple SL/U4/U5/U6 snRNP namespace: biological_process def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897] comment: Note that this step is analogous to 5' splice site selection in cis-splicing. is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition [Term] id: GO:0000354 name: cis assembly of pre-catalytic spliceosome namespace: biological_process alt_id: GO:0000360 alt_id: GO:0000361 def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals). synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW [] synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW [] synonym: "formation of spliceosomal A2-1 complex" NARROW [] synonym: "formation of spliceosomal B1 complex" NARROW [] synonym: "spliceosomal A2-1 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-1 complex formation" NARROW [] synonym: "spliceosomal B1 complex biosynthesis" NARROW [] synonym: "spliceosomal B1 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosome assembly relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome [Term] id: GO:0000362 name: first U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000363 name: first U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000364 name: second U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000365 name: nuclear mRNA trans splicing, via spliceosome namespace: biological_process def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897] synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW [] is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000366 name: intergenic nuclear mRNA trans splicing namespace: biological_process def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900] is_a: GO:0000365 ! nuclear mRNA trans splicing, via spliceosome is_a: GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome [Term] id: GO:0000367 name: second U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000372 name: Group I intron splicing namespace: biological_process def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794] comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone). subset: gosubset_prok synonym: "mRNA splicing" RELATED [] is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile [Term] id: GO:0000373 name: Group II intron splicing namespace: biological_process def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794] comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria. subset: gosubset_prok synonym: "mRNA splicing" RELATED [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000374 name: Group III intron splicing namespace: biological_process def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794] comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists. subset: gosubset_prok synonym: "mRNA splicing" RELATED [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000375 name: RNA splicing, via transesterification reactions namespace: biological_process alt_id: GO:0000385 alt_id: GO:0031202 def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. subset: gosubset_prok synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah] synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah] synonym: "spliceosomal catalysis" RELATED [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000376 name: RNA splicing, via transesterification reactions with guanosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794] subset: gosubset_prok is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000377 name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] subset: gosubset_prok synonym: "lariat RNA biosynthesis" RELATED [] synonym: "lariat RNA formation" RELATED [] is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000378 name: RNA exon ligation namespace: biological_process def: "The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897] comment: Note that this is not a part of spliceosomal RNA splicing. subset: gosubset_prok is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000379 name: tRNA-type intron splice site recognition and cleavage namespace: biological_process def: "RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897] subset: gosubset_prok is_a: GO:0006396 ! RNA processing relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000380 name: alternative nuclear mRNA splicing, via spliceosome namespace: biological_process def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals. synonym: "splice site selection" BROAD [] is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000381 name: regulation of alternative nuclear mRNA splicing, via spliceosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] synonym: "splice site selection" BROAD [] is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome relationship: regulates GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome [Term] id: GO:0000384 name: first spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000386 name: second spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000387 name: spliceosomal snRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897] synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah] xref: Reactome:1237264 "snRNP:Snurportin complex formation" xref: Reactome:1237271 "snRNA Cap hypermethylation" xref: Reactome:1237272 "snRNP complex assembly" xref: Reactome:1253460 "snRNP Assembly" xref: Reactome:1264453 "snRNP:Snurportin complex formation" xref: Reactome:1264460 "snRNA Cap hypermethylation" xref: Reactome:1264461 "snRNP complex assembly" xref: Reactome:1280398 "snRNP Assembly" xref: Reactome:1288855 "snRNP:Snurportin complex formation" xref: Reactome:1288862 "snRNA Cap hypermethylation" xref: Reactome:1288863 "snRNP complex assembly" xref: Reactome:1299235 "snRNP Assembly" xref: Reactome:1310841 "snRNP:Snurportin complex formation" xref: Reactome:1310848 "snRNA Cap hypermethylation" xref: Reactome:1310849 "snRNP complex assembly" xref: Reactome:1326976 "snRNP Assembly" xref: Reactome:1337956 "snRNP:Snurportin complex formation" xref: Reactome:1337963 "snRNA Cap hypermethylation" xref: Reactome:1337964 "snRNP complex assembly" xref: Reactome:1353071 "snRNP Assembly" xref: Reactome:1361592 "snRNP:Snurportin complex formation" xref: Reactome:1361599 "snRNA Cap hypermethylation" xref: Reactome:1361600 "snRNP complex assembly" xref: Reactome:1373261 "snRNP Assembly" xref: Reactome:1393280 "snRNP Assembly" xref: Reactome:1403876 "snRNP:Snurportin complex formation" xref: Reactome:1403883 "snRNA Cap hypermethylation" xref: Reactome:1403884 "snRNP complex assembly" xref: Reactome:1417772 "snRNP Assembly" xref: Reactome:1432179 "snRNP:Snurportin complex formation" xref: Reactome:1432186 "snRNA Cap hypermethylation" xref: Reactome:1432187 "snRNP complex assembly" xref: Reactome:1432212 "Loading and methylation of Sm proteins onto SMN Complexes" xref: Reactome:1450872 "snRNP Assembly" xref: Reactome:1460876 "snRNP:Snurportin complex formation" xref: Reactome:1460887 "snRNA Cap hypermethylation" xref: Reactome:1460888 "snRNP complex assembly" xref: Reactome:1471263 "snRNP Assembly" xref: Reactome:191763 "snRNP:Snurportin complex formation" xref: Reactome:191784 "snRNA Cap hypermethylation" xref: Reactome:191786 "snRNP complex assembly" xref: Reactome:191790 "Loading and methylation of Sm proteins onto SMN Complexes" xref: Reactome:191859 "snRNP Assembly" is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000388 name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) namespace: biological_process alt_id: GO:0000396 alt_id: GO:0000397 def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian). synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "spliceosomal A1 complex biosynthesis" NARROW [] synonym: "spliceosomal A1 complex formation" NARROW [] synonym: "spliceosomal B2 complex biosynthesis" NARROW [] synonym: "spliceosomal B2 complex formation" NARROW [] synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW [] synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000389 name: nuclear mRNA 3'-splice site recognition namespace: biological_process alt_id: GO:0000382 alt_id: GO:0000383 def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897] synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection [Term] id: GO:0000390 name: spliceosome disassembly namespace: biological_process alt_id: GO:0000391 alt_id: GO:0000392 def: "Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "spliceosome complex disassembly" EXACT [] synonym: "U12-type spliceosome disassembly" NARROW [] synonym: "U2-type spliceosome disassembly" NARROW [] is_a: GO:0032988 ! ribonucleoprotein complex disassembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000393 name: spliceosomal conformational changes to generate catalytic conformation namespace: biological_process def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc] synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000394 name: RNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897] comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. subset: gosubset_prok synonym: "mRNA splicing" BROAD [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000395 name: nuclear mRNA 5'-splice site recognition namespace: biological_process alt_id: GO:0000368 alt_id: GO:0000369 def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian). synonym: "nuclear mRNA 5' splice site recognition" EXACT [] synonym: "spliceosomal CC complex biosynthesis" NARROW [] synonym: "spliceosomal CC complex formation" NARROW [] synonym: "spliceosomal commitment complex biosynthesis" NARROW [] synonym: "spliceosomal commitment complex formation" NARROW [] synonym: "spliceosomal E complex biosynthesis" NARROW [] synonym: "spliceosomal E complex formation" NARROW [] synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome [Term] id: GO:0000398 name: nuclear mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0006374 alt_id: GO:0006375 def: "The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0879695897] comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. synonym: "mRNA splicing" BROAD [] synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "pre-mRNA splicing" BROAD [] synonym: "splicing AT-AC intron" RELATED [] synonym: "splicing GT-AG intron" RELATED [] xref: Reactome:1252971 "mRNA Splicing - Major Pathway" xref: Reactome:1253042 "mRNA Splicing - Minor Pathway" xref: Reactome:1279901 "mRNA Splicing - Major Pathway" xref: Reactome:1279974 "mRNA Splicing - Minor Pathway" xref: Reactome:1326474 "mRNA Splicing - Major Pathway" xref: Reactome:1326547 "mRNA Splicing - Minor Pathway" xref: Reactome:1352588 "mRNA Splicing - Major Pathway" xref: Reactome:1352659 "mRNA Splicing - Minor Pathway" xref: Reactome:1372813 "mRNA Splicing - Major Pathway" xref: Reactome:1372875 "mRNA Splicing - Minor Pathway" xref: Reactome:1417301 "mRNA Splicing - Major Pathway" xref: Reactome:1417366 "mRNA Splicing - Minor Pathway" xref: Reactome:1450391 "mRNA Splicing - Major Pathway" xref: Reactome:1450467 "mRNA Splicing - Minor Pathway" xref: Reactome:1470918 "mRNA Splicing - Major Pathway" xref: Reactome:1470984 "mRNA Splicing - Minor Pathway" xref: Reactome:1482955 "mRNA Splicing - Major Pathway" xref: Reactome:1483014 "mRNA Splicing - Minor Pathway" xref: Reactome:1496781 "mRNA Splicing - Minor Pathway" xref: Reactome:1514171 "mRNA Splicing - Minor Pathway" xref: Reactome:1521006 "mRNA Splicing - Minor Pathway" xref: Reactome:1532471 "mRNA Splicing - Minor Pathway" xref: Reactome:1536011 "mRNA Splicing - Minor Pathway" xref: Reactome:72163 "mRNA Splicing - Major Pathway" xref: Reactome:72165 "mRNA Splicing - Minor Pathway" is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile is_a: GO:0006397 ! mRNA processing [Term] id: GO:0000399 name: cellular bud neck septin structure namespace: cellular_component def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc] is_a: GO:0032155 ! cell division site part relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000400 name: four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "forked DNA binding" BROAD [] synonym: "Holliday junction binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000401 name: open form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "open form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000402 name: crossed form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "crossed form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000403 name: Y-form DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] synonym: "forked DNA binding" BROAD [] synonym: "splayed Y-form DNA binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000404 name: loop DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0000405 name: bubble DNA binding namespace: molecular_function def: "Interacting selective with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000406 name: double-strand/single-strand DNA junction binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000407 name: pre-autophagosomal structure namespace: cellular_component def: "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] synonym: "isolation membrane" RELATED [] synonym: "PAS" EXACT [] synonym: "perivacuolar space" NARROW [] synonym: "phagophore" RELATED [GOC:bf] synonym: "phagophore assembly site" RELATED [] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000408 name: EKC/KEOPS protein complex namespace: cellular_component def: "A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, PMID:16564010, PMID:16874308] synonym: "Endopeptidase-like Kinase Chromatin-associated protein complex" EXACT [] synonym: "Kinase, putative Endopeptidase and Other Proteins of Small size protein complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000409 name: regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] subset: gosubset_prok is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0000410 name: negative regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that stops, prevents or reduces the rate of transcription." [GOC:mah] synonym: "down regulation of transcription by galactose" EXACT [] synonym: "down-regulation of transcription by galactose" EXACT [] synonym: "downregulation of transcription by galactose" EXACT [] synonym: "inhibition of transcription by galactose" NARROW [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045013 ! carbon catabolite repression of transcription [Term] id: GO:0000411 name: positive regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators] synonym: "activation of transcription by galactose" NARROW [] synonym: "stimulation of transcription by galactose" NARROW [] synonym: "up regulation of transcription by galactose" EXACT [] synonym: "up-regulation of transcription by galactose" EXACT [] synonym: "upregulation of transcription by galactose" EXACT [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045991 ! carbon catabolite activation of transcription [Term] id: GO:0000412 name: histone peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc] synonym: "histone proline isomerization" EXACT [] is_a: GO:0000413 ! protein peptidyl-prolyl isomerization is_a: GO:0016570 ! histone modification [Term] id: GO:0000413 name: protein peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] synonym: "protein proline isomerization" EXACT [] is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0000414 name: regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] is_a: GO:0031060 ! regulation of histone methylation relationship: regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000415 name: negative regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "down regulation of histone H3-K36 methylation" EXACT [] synonym: "down-regulation of histone H3-K36 methylation" EXACT [] synonym: "downregulation of histone H3-K36 methylation" EXACT [] synonym: "inhibition of histone H3-K36 methylation" NARROW [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031061 ! negative regulation of histone methylation relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000416 name: positive regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "activation of histone H3-K36 methylation" NARROW [] synonym: "stimulation of histone H3-K36 methylation" NARROW [] synonym: "up regulation of histone H3-K36 methylation" EXACT [] synonym: "up-regulation of histone H3-K36 methylation" EXACT [] synonym: "upregulation of histone H3-K36 methylation" EXACT [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031062 ! positive regulation of histone methylation relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000417 name: HIR complex namespace: cellular_component def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700] synonym: "HIRA complex" EXACT [PMID:19620282, PMID:20976105] is_a: GO:0005678 ! chromatin assembly complex [Term] id: GO:0000418 name: DNA-directed RNA polymerase IV complex namespace: cellular_component def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants. In addition to RNA polymerases I, II, and III, the essential RNA polymerases present in all eukaryotes, plants have two additional nuclear RNA polymerases, Pol IV and Pol V, that play nonredundant roles in siRNA-directed DNA methylation and gene silencing. Pol IV is required for siRNA production and Pol V is required for generating noncoding transcripts at target loci. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0000419 name: DNA-directed RNA polymerase IVb complex namespace: cellular_component def: "RNA polymerase IVb is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984] is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex [Term] id: GO:0000420 name: DNA-directed RNA polymerase IVa complex namespace: cellular_component def: "RNA polymerase IVa is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVb, while the largest subunit is found only in the IVa complex. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984] is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex [Term] id: GO:0000421 name: autophagic vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:isa_complete] synonym: "autophagosome membrane" EXACT [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0005776 ! autophagic vacuole [Term] id: GO:0000422 name: mitochondrion degradation namespace: biological_process def: "The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [PMID:15798367] synonym: "mitophagy" EXACT [] xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy xref: Wikipedia:Mitophagy is_a: GO:0006914 ! autophagy [Term] id: GO:0000423 name: macromitophagy namespace: biological_process def: "Degradation of a mitochondrion by macroautophagy." [PMID:15798367] is_a: GO:0000422 ! mitochondrion degradation is_a: GO:0016236 ! macroautophagy [Term] id: GO:0000424 name: micromitophagy namespace: biological_process def: "Degradation of a mitochondrion by microautophagy." [PMID:15798367] is_a: GO:0000422 ! mitochondrion degradation is_a: GO:0016237 ! microautophagy [Term] id: GO:0000425 name: macropexophagy namespace: biological_process def: "Degradation of a peroxisome by macropexophagy." [PMID:12914914, PMID:16973210] is_a: GO:0016236 ! macroautophagy is_a: GO:0030242 ! peroxisome degradation [Term] id: GO:0000426 name: micropexophagy namespace: biological_process def: "Degradation of a peroxisome by micropexophagy." [PMID:12914914, PMID:16973210] is_a: GO:0016237 ! microautophagy is_a: GO:0030242 ! peroxisome degradation [Term] id: GO:0000427 name: plastid-encoded plastid RNA polymerase complex namespace: cellular_component def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj] is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044435 ! plastid part [Term] id: GO:0000428 name: DNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] is_a: GO:0030880 ! RNA polymerase complex [Term] id: GO:0000429 name: carbon catabolite regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc, GOC:mah] synonym: "regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0000430 name: regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0046015 ! regulation of transcription by glucose [Term] id: GO:0000431 name: regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter [Term] id: GO:0000432 name: positive regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter is_a: GO:0046016 ! positive regulation of transcription by glucose [Term] id: GO:0000433 name: negative regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW [] is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter is_a: GO:0045014 ! negative regulation of transcription by glucose [Term] id: GO:0000434 name: negative regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW [] is_a: GO:0000410 ! negative regulation of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter [Term] id: GO:0000435 name: positive regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] is_a: GO:0000411 ! positive regulation of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter [Term] id: GO:0000436 name: carbon catabolite activation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "positive regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter [Term] id: GO:0000437 name: carbon catabolite repression of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc] synonym: "negative regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter [Term] id: GO:0000438 name: core TFIIH complex portion of holo TFIIH complex namespace: cellular_component def: "The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000439 ! core TFIIH complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0000443 ! SSL2-core TFIIH complex portion of holo TFIIH complex [Term] id: GO:0000439 name: core TFIIH complex namespace: cellular_component def: "The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex relationship: part_of GO:0000441 ! SSL2-core TFIIH complex [Term] id: GO:0000440 name: core TFIIH complex portion of NEF3 complex namespace: cellular_component def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000439 ! core TFIIH complex relationship: part_of GO:0000442 ! SSL2-core TFIIH complex portion of NEF3 complex [Term] id: GO:0000441 name: SSL2-core TFIIH complex namespace: cellular_component def: "A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] subset: goslim_pir is_a: GO:0043234 ! protein complex [Term] id: GO:0000442 name: SSL2-core TFIIH complex portion of NEF3 complex namespace: cellular_component def: "The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000441 ! SSL2-core TFIIH complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex [Term] id: GO:0000443 name: SSL2-core TFIIH complex portion of holo TFIIH complex namespace: cellular_component def: "The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000441 ! SSL2-core TFIIH complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0005675 ! holo TFIIH complex [Term] id: GO:0000444 name: MIS12/MIND type complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270] synonym: "Mis12 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000445 name: THO complex part of transcription export complex namespace: cellular_component def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] synonym: "THO complex part of TREX complex" EXACT [] is_a: GO:0000347 ! THO complex relationship: part_of GO:0000346 ! transcription export complex [Term] id: GO:0000446 name: nucleoplasmic THO complex namespace: cellular_component def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] is_a: GO:0000347 ! THO complex is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0000447 name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A2" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000448 name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process alt_id: GO:0000490 def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "cleavage at C2" RELATED [] synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000449 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000450 name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000451 name: rRNA 2'-O-methylation namespace: biological_process def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0031167 ! rRNA methylation [Term] id: GO:0000452 name: snoRNA guided rRNA 2'-O-methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000453 name: enzyme-directed rRNA 2'-O-methylation namespace: biological_process def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000454 name: snoRNA guided rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000455 name: enzyme-directed rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000456 name: dimethylation involved in SSU-rRNA maturation namespace: biological_process def: "Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, GOC:dph, GOC:tb, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0031167 ! rRNA methylation relationship: part_of GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000457 name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000458 name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000459 name: exonucleolytic trimming involved in rRNA processing namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators] synonym: "exonucleolytic trimming during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing [Term] id: GO:0000460 name: maturation of 5.8S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000461 name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at site D" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000462 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000463 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000464 name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at A3" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000465 name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000466 name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000467 name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000468 name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] synonym: "processing at B2" NARROW [] is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000469 name: cleavage involved in rRNA processing namespace: biological_process def: "Any cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators] synonym: "cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0006364 ! rRNA processing [Term] id: GO:0000470 name: maturation of LSU-rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis [Term] id: GO:0000471 name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000472 name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A1" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000473 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000474 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000475 name: maturation of 2S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000476 name: maturation of 4.5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000477 name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "processing at C1" NARROW [] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000478 name: endonucleolytic cleavage involved in rRNA processing namespace: biological_process def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing [Term] id: GO:0000479 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000480 name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326] synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326] synonym: "endonucleolytic cleavage at A0" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000481 name: maturation of 5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000482 name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000481 ! maturation of 5S rRNA [Term] id: GO:0000483 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000484 name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000485 name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA [Term] id: GO:0000486 name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000487 name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000488 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000489 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000491 name: small nucleolar ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "snoRNP assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly [Term] id: GO:0000492 name: box C/D snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000493 name: box H/ACA snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383] synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000494 name: box C/D snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box C/D snoRNA molecule." [GOC:krc] synonym: "box C/D snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034963 ! box C/D snoRNA processing [Term] id: GO:0000495 name: box H/ACA snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc] synonym: "box H/ACA snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034964 ! box H/ACA snoRNA processing [Term] id: GO:0000496 name: base pairing namespace: molecular_function def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: Wikipedia:Base_pair is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0000497 name: base pairing with DNA namespace: molecular_function def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000496 ! base pairing is_a: GO:0003677 ! DNA binding [Term] id: GO:0000498 name: base pairing with RNA namespace: molecular_function def: "Interacting selectively and non-covalently with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000496 ! base pairing is_a: GO:0003723 ! RNA binding [Term] id: GO:0000499 name: base pairing with mRNA namespace: molecular_function def: "Interacting selectively and non-covalently with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000498 ! base pairing with RNA [Term] id: GO:0000500 name: RNA polymerase I upstream activating factor complex namespace: cellular_component def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378] synonym: "RNA polymerase I upstream activation factor complex" EXACT [] synonym: "UAF" EXACT [] is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0000501 name: flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "Mannose-sensitive, nonsexual aggregation of cells mediated by protein-carbohydrate (flocculin-mannan) interaction present in the cell wall. This process is pH- and calcium-dependent and reversible. An example of this process is found in Saccharomyces cerevisiae." [DOI:10.1016/S0963-9969(99)00021-6, GOC:sgd_curators] subset: gosubset_prok is_a: GO:0000128 ! flocculation [Term] id: GO:0000502 name: proteasome complex namespace: cellular_component def: "A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb] subset: goslim_pir synonym: "26S proteasome" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000504 name: proteasome regulatory particle (sensu Bacteria) namespace: cellular_component def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb] comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase. synonym: "26S proteasome" NARROW [] is_obsolete: true [Term] id: GO:0000506 name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411] comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity. synonym: "GPI-GlcNAc transferase complex" EXACT [] synonym: "GPI-GnT complex" EXACT [] synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0000578 name: embryonic axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] synonym: "embryonic axis determination" RELATED [] is_a: GO:0009798 ! axis specification is_a: GO:0009880 ! embryonic pattern specification [Term] id: GO:0000700 name: mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000701 name: purine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623] synonym: "A/G-specific adenine DNA glycosylase activity" NARROW [] xref: EC:3.2.2.- is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity [Term] id: GO:0000702 name: oxidized base lesion DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] subset: gosubset_prok is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000703 name: oxidized pyrimidine base lesion DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0019004 def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. subset: gosubset_prok synonym: "bifunctional DNA glycosylase" BROAD [] synonym: "DNA glycosylase/AP-lyase" BROAD [] synonym: "DNA glycosylase/beta-lyase" BROAD [] synonym: "endodeoxyribonuclease III" RELATED [] synonym: "endonuclease III" RELATED [] synonym: "endonuclease VIII activity" RELATED [] synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: Reactome:25087 "oxidized pyrimidine base lesion DNA N-glycosylase activity" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity [Term] id: GO:0000704 name: pyrimidine dimer DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000705 name: achiasmate meiosis I namespace: biological_process def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419] is_a: GO:0007127 ! meiosis I [Term] id: GO:0000706 name: meiotic DNA double-strand break processing namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] is_a: GO:0000729 ! DNA double-strand break processing is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000707 name: meiotic DNA recombinase assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983] is_a: GO:0000730 ! DNA recombinase assembly is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000708 name: meiotic strand invasion namespace: biological_process def: "The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877] synonym: "meiotic D-loop biosynthesis" RELATED [] synonym: "meiotic D-loop formation" RELATED [] synonym: "meiotic displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop formation" RELATED [GOC:mah, GOC:vw] is_a: GO:0022402 ! cell cycle process is_a: GO:0042148 ! strand invasion relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000709 name: meiotic joint molecule formation namespace: biological_process def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0000710 name: meiotic mismatch repair namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] is_a: GO:0006298 ! mismatch repair is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000711 name: meiotic DNA repair synthesis namespace: biological_process def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000712 name: resolution of meiotic recombination intermediates namespace: biological_process def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053] synonym: "crossover biosynthesis" NARROW [] synonym: "crossover formation" NARROW [] synonym: "formation of chiasmata" NARROW [] synonym: "homologous chromosome separation at meiosis I" EXACT [] synonym: "meiotic homologous chromosome separation" RELATED [] synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah] is_a: GO:0051307 ! meiotic chromosome separation relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0000713 name: meiotic heteroduplex formation namespace: biological_process def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324] is_a: GO:0022402 ! cell cycle process is_a: GO:0030491 ! heteroduplex formation relationship: part_of GO:0006310 ! DNA recombination relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000714 name: meiotic strand displacement namespace: biological_process def: "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855] synonym: "meiotic D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0000732 ! strand displacement is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000715 name: nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] xref: Reactome:1253164 "DNA Damage Recognition in GG-NER" xref: Reactome:1298979 "DNA Damage Recognition in GG-NER" xref: Reactome:1326669 "DNA Damage Recognition in GG-NER" xref: Reactome:1352781 "DNA Damage Recognition in GG-NER" xref: Reactome:1372991 "DNA Damage Recognition in GG-NER" xref: Reactome:1393007 "DNA Damage Recognition in GG-NER" xref: Reactome:1450581 "DNA Damage Recognition in GG-NER" xref: Reactome:1471088 "DNA Damage Recognition in GG-NER" xref: Reactome:1496825 "DNA Damage Recognition in GG-NER" xref: Reactome:1514219 "DNA Damage Recognition in GG-NER" xref: Reactome:1521058 "DNA Damage Recognition in GG-NER" xref: Reactome:1526827 "DNA Damage Recognition in GG-NER" xref: Reactome:1532553 "DNA Damage Recognition in GG-NER" xref: Reactome:73940 "DNA Damage Recognition in GG-NER" is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000716 name: transcription-coupled nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] xref: Reactome:109972 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1230776 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1258574 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1304509 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1332140 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1356772 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1377770 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1398100 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1424453 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1456316 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1475153 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1488236 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1503078 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1517081 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1523994 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1529699 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:1534409 "RNA Pol II is blocked by the lesion leading to reduced transcription" is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair [Term] id: GO:0000717 name: nucleotide-excision repair, DNA duplex unwinding namespace: biological_process def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok xref: Reactome:1229045 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1256783 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1282644 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1302873 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1330243 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1355372 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1376348 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1396472 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1422242 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1454680 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1486885 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1501424 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1523452 "Formation of open bubble structure in DNA by helicases" xref: Reactome:1529068 "Formation of open bubble structure in DNA by helicases" xref: Reactome:73934 "Formation of open bubble structure in DNA by helicases" is_a: GO:0032508 ! DNA duplex unwinding relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000718 name: nucleotide-excision repair, DNA damage removal namespace: biological_process def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok xref: Reactome:1253013 "Dual incision reaction in GG-NER" xref: Reactome:1279943 "Dual incision reaction in GG-NER" xref: Reactome:1298836 "Dual incision reaction in GG-NER" xref: Reactome:1326517 "Dual incision reaction in GG-NER" xref: Reactome:1352624 "Dual incision reaction in GG-NER" xref: Reactome:1372852 "Dual incision reaction in GG-NER" xref: Reactome:1392865 "Dual incision reaction in GG-NER" xref: Reactome:1417343 "Dual incision reaction in GG-NER" xref: Reactome:1450432 "Dual incision reaction in GG-NER" xref: Reactome:1470960 "Dual incision reaction in GG-NER" xref: Reactome:1482994 "Dual incision reaction in GG-NER" xref: Reactome:1496771 "Dual incision reaction in GG-NER" xref: Reactome:1514161 "Dual incision reaction in GG-NER" xref: Reactome:1526739 "Dual incision reaction in GG-NER" xref: Reactome:1532463 "Dual incision reaction in GG-NER" xref: Reactome:73941 "Dual incision reaction in GG-NER" is_a: GO:0006308 ! DNA catabolic process relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000719 name: photoreactive repair namespace: biological_process def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863] subset: gosubset_prok synonym: "pyrimidine-dimer repair by photolyase" NARROW [] is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000720 name: pyrimidine dimer repair by nucleotide-excision repair namespace: biological_process def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh] comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'. subset: gosubset_prok is_a: GO:0006289 ! nucleotide-excision repair is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000721 name: (R,R)-butanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+." [EC:1.1.1.4] subset: gosubset_prok synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4] xref: EC:1.1.1.4 xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000722 name: telomere maintenance via recombination namespace: biological_process def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777] synonym: "telomerase-independent telomere maintenance" RELATED [] xref: Reactome:1235588 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1235590 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1235593 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1235596 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1235600 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:1235603 "Formation of C-strand Okazaki fragments" xref: Reactome:1235604 "RPA binds to the Flap on the C-strand" xref: Reactome:1235606 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1235607 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:1235608 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1235609 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1235611 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1253406 "Telomere C-strand synthesis initiation" xref: Reactome:1253408 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1253409 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1253410 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1262893 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1262895 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1262898 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1262901 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1262905 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:1262908 "Formation of C-strand Okazaki fragments" xref: Reactome:1262909 "RPA binds to the Flap on the C-strand" xref: Reactome:1262911 "Removal of remaining Flap from the C-strand" xref: Reactome:1262912 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1262913 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:1262914 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1262915 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1262917 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1280345 "Telomere C-strand synthesis initiation" xref: Reactome:1280347 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1280348 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1280349 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1287521 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1287524 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1287531 "Formation of C-strand Okazaki fragments" xref: Reactome:1287533 "Removal of remaining Flap from the C-strand" xref: Reactome:1287534 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1287535 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1287537 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1299185 "Telomere C-strand synthesis initiation" xref: Reactome:1299187 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1299188 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1299189 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1309182 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1309184 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1309187 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1309190 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1309194 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:1309197 "Formation of C-strand Okazaki fragments" xref: Reactome:1309198 "RPA binds to the Flap on the C-strand" xref: Reactome:1309200 "Removal of remaining Flap from the C-strand" xref: Reactome:1309201 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1309202 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:1309203 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1309204 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1309206 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1326923 "Telomere C-strand synthesis initiation" xref: Reactome:1326925 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1326926 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1326927 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1336256 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1336258 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1336261 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1336264 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1336268 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:1336271 "Formation of C-strand Okazaki fragments" xref: Reactome:1336272 "RPA binds to the Flap on the C-strand" xref: Reactome:1336274 "Removal of remaining Flap from the C-strand" xref: Reactome:1336275 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1336276 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:1336277 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1336278 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1336280 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1353015 "Telomere C-strand synthesis initiation" xref: Reactome:1353020 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1353021 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1353022 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1360270 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1360272 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1373210 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1381087 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1381089 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1381092 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1381097 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1381098 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1381099 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1393225 "Telomere C-strand synthesis initiation" xref: Reactome:1393227 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1393228 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1393229 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1402197 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1402199 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1402202 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1402205 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1402209 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:1402212 "Formation of C-strand Okazaki fragments" xref: Reactome:1402213 "RPA binds to the Flap on the C-strand" xref: Reactome:1402215 "Removal of remaining Flap from the C-strand" xref: Reactome:1402216 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1402217 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:1402218 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1402219 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1402221 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1417720 "Telomere C-strand synthesis initiation" xref: Reactome:1417725 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1417726 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1417727 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1430240 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1430242 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1430245 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1430248 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1430252 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:1430255 "Formation of C-strand Okazaki fragments" xref: Reactome:1430256 "RPA binds to the Flap on the C-strand" xref: Reactome:1430258 "Removal of remaining Flap from the C-strand" xref: Reactome:1430259 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1430260 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:1430261 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1430262 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1430264 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1450820 "Telomere C-strand synthesis initiation" xref: Reactome:1450822 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1450823 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1450824 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1458968 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1458970 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1458973 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1458975 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1458976 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1471231 "Telomere C-strand synthesis initiation" xref: Reactome:1471236 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1476566 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1476568 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1476571 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1476573 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1476574 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1483220 "Telomere C-strand synthesis initiation" xref: Reactome:1483225 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1490130 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1490132 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1490135 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1490138 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1490144 "Formation of C-strand Okazaki fragments" xref: Reactome:1490146 "Removal of remaining Flap from the C-strand" xref: Reactome:1490147 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1490148 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:1490149 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1490150 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1490152 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1496914 "Telomere C-strand synthesis initiation" xref: Reactome:1496916 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1496917 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1496918 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1505269 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1505271 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1505274 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1505277 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1505283 "Formation of C-strand Okazaki fragments" xref: Reactome:1505285 "Removal of remaining Flap from the C-strand" xref: Reactome:1505286 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1505287 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:1505288 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1505289 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1505291 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1514303 "Telomere C-strand synthesis initiation" xref: Reactome:1514305 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1514306 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1514307 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1518100 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1518102 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1518105 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1518107 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1518108 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1521169 "Telomere C-strand synthesis initiation" xref: Reactome:1521171 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1524586 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1524588 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1524591 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1524593 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1524594 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1526913 "Telomere C-strand synthesis initiation" xref: Reactome:1526915 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1530494 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1530496 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1530499 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:1530502 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1530508 "Formation of C-strand Okazaki fragments" xref: Reactome:1530510 "Removal of remaining Flap from the C-strand" xref: Reactome:1530511 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1530512 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:1530513 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:1530514 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1530516 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:1532648 "Telomere C-strand synthesis initiation" xref: Reactome:1532650 "Processive synthesis on the C-strand of the telomere" xref: Reactome:1532651 "Polymerase switching on the C-strand of the telomere" xref: Reactome:1532652 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:1534770 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:1534772 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:1534775 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:1534777 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:1534778 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:1536075 "Telomere C-strand synthesis initiation" xref: Reactome:1536080 "Polymerase switching on the C-strand of the telomere" xref: Reactome:174411 "Polymerase switching on the C-strand of the telomere" xref: Reactome:174414 "Processive synthesis on the C-strand of the telomere" xref: Reactome:174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:174427 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:174430 "Telomere C-strand synthesis initiation" xref: Reactome:174437 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:174438 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:174439 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:174444 "Formation of C-strand Okazaki fragments" xref: Reactome:174445 "RPA binds to the Flap on the C-strand" xref: Reactome:174446 "Removal of remaining Flap from the C-strand" xref: Reactome:174447 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:174448 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:174451 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:174452 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:174456 "Joining of adjacent Okazaki fragments of the C-strand" is_a: GO:0000723 ! telomere maintenance is_a: GO:0006312 ! mitotic recombination [Term] id: GO:0000723 name: telomere maintenance namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb] xref: Reactome:1235948 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:1253323 "Telomere Maintenance" xref: Reactome:1263255 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:1280261 "Telomere Maintenance" xref: Reactome:1280352 "Packaging Of Telomere Ends" xref: Reactome:1299118 "Telomere Maintenance" xref: Reactome:1299192 "Packaging Of Telomere Ends" xref: Reactome:1309628 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:1326839 "Telomere Maintenance" xref: Reactome:1326930 "Packaging Of Telomere Ends" xref: Reactome:1336567 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:1353018 "Telomere Maintenance" xref: Reactome:1353025 "Packaging Of Telomere Ends" xref: Reactome:1373139 "Telomere Maintenance" xref: Reactome:1373215 "Packaging Of Telomere Ends" xref: Reactome:1393155 "Telomere Maintenance" xref: Reactome:1402556 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:1417723 "Telomere Maintenance" xref: Reactome:1430625 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:1450741 "Telomere Maintenance" xref: Reactome:1471234 "Telomere Maintenance" xref: Reactome:1483223 "Telomere Maintenance" xref: Reactome:1490169 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:1496879 "Telomere Maintenance" xref: Reactome:1505318 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:1514272 "Telomere Maintenance" xref: Reactome:1521129 "Telomere Maintenance" xref: Reactome:1526889 "Telomere Maintenance" xref: Reactome:1530555 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:1532618 "Telomere Maintenance" xref: Reactome:1536078 "Telomere Maintenance" xref: Reactome:157579 "Telomere Maintenance" xref: Reactome:171306 "Packaging Of Telomere Ends" xref: Reactome:176702 "Disassociation of Processive Complex and Completed Telomere End" is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032200 ! telomere organization is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0000724 name: double-strand break repair via homologous recombination namespace: biological_process alt_id: GO:0016924 def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] subset: gosubset_prok synonym: "HDR" EXACT [GOC:vk] synonym: "homologous recombinational repair" EXACT [] synonym: "homology-directed repair" EXACT [GOC:vk] synonym: "HRR" EXACT [] synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah] synonym: "Rhp51-dependent recombinational repair" EXACT [] xref: Reactome:1253051 "Homologous Recombination Repair" xref: Reactome:1279987 "Homologous Recombination Repair" xref: Reactome:1298880 "Homologous Recombination Repair" xref: Reactome:1326557 "Homologous Recombination Repair" xref: Reactome:1352669 "Homologous Recombination Repair" xref: Reactome:1372885 "Homologous Recombination Repair" xref: Reactome:1392905 "Homologous Recombination Repair" xref: Reactome:1417375 "Homologous Recombination Repair" xref: Reactome:1450476 "Homologous Recombination Repair" xref: Reactome:1470990 "Homologous Recombination Repair" xref: Reactome:1483018 "Homologous Recombination Repair" xref: Reactome:1496785 "Homologous Recombination Repair" xref: Reactome:1514175 "Homologous Recombination Repair" xref: Reactome:1521015 "Homologous Recombination Repair" xref: Reactome:1526749 "Homologous Recombination Repair" xref: Reactome:1532480 "Homologous Recombination Repair" xref: Reactome:1536017 "Homologous Recombination Repair" xref: Reactome:1539266 "Homologous Recombination Repair" xref: Reactome:73888 "Homologous Recombination Repair" is_a: GO:0000725 ! recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0000725 name: recombinational repair namespace: biological_process def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] subset: gosubset_prok xref: Wikipedia:Recombinational_repair is_a: GO:0006281 ! DNA repair is_a: GO:0006310 ! DNA recombination [Term] id: GO:0000726 name: non-recombinational repair namespace: biological_process def: "A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0000727 name: double-strand break repair via break-induced replication namespace: biological_process def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] subset: gosubset_prok is_a: GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0000728 name: gene conversion at mating-type locus, DNA double-strand break formation namespace: biological_process def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000729 name: DNA double-strand break processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855] xref: Reactome:83897 "Resection of double-strand break ends" is_a: GO:0000738 ! DNA catabolic process, exonucleolytic relationship: part_of GO:0006302 ! double-strand break repair [Term] id: GO:0000730 name: DNA recombinase assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855] synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw] xref: Reactome:1253110 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1280045 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1298930 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1326615 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1352728 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1372939 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1392955 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1417435 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1450528 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1471041 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1483058 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1496824 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1514218 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1521049 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1526772 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1532500 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:1536024 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:76000 "Assembly of the RAD51-ssDNA nucleoprotein complex" is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0000731 name: DNA synthesis involved in DNA repair namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template." [PMID:10357855] subset: gosubset_prok synonym: "DNA repair synthesis" BROAD [] synonym: "DNA synthesis during DNA repair" RELATED [GOC:dph, GOC:tb] synonym: "mitotic DNA repair synthesis" NARROW [GOC:mah] xref: Reactome:76011 "DNA repair synthesis" is_a: GO:0071897 ! DNA biosynthetic process relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0000732 name: strand displacement namespace: biological_process def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855] subset: gosubset_prok synonym: "D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop processing" RELATED [GOC:mah, GOC:vw] xref: Reactome:83663 "Dissociation of the extended strands" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000733 name: DNA strand renaturation namespace: biological_process def: "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0000734 name: gene conversion at mating-type locus, DNA repair synthesis namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus." [GOC:elh] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000735 name: removal of nonhomologous ends namespace: biological_process def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] is_a: GO:0000737 ! DNA catabolic process, endonucleolytic is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000736 name: double-strand break repair via single-strand annealing, removal of nonhomologous ends namespace: biological_process def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] subset: gosubset_prok is_a: GO:0000735 ! removal of nonhomologous ends relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0000737 name: DNA catabolic process, endonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] subset: gosubset_prok synonym: "DNA breakdown, endonucleolytic" EXACT [] synonym: "DNA degradation, endonucleolytic" EXACT [] synonym: "endonucleolytic degradation of DNA" EXACT [] synonym: "endonucleolytic DNA catabolism" EXACT [] is_a: GO:0006308 ! DNA catabolic process [Term] id: GO:0000738 name: DNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] subset: gosubset_prok synonym: "DNA breakdown, exonucleolytic" EXACT [] synonym: "DNA degradation, exonucleolytic" EXACT [] synonym: "exonucleolytic degradation of DNA" EXACT [] is_a: GO:0006308 ! DNA catabolic process [Term] id: GO:0000739 name: DNA strand annealing activity namespace: molecular_function def: "Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh] is_a: GO:0003690 ! double-stranded DNA binding is_a: GO:0003697 ! single-stranded DNA binding [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0090174 ! organelle membrane fusion [Term] id: GO:0000741 name: karyogamy namespace: biological_process alt_id: GO:0007335 def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0006997 ! nucleus organization [Term] id: GO:0000742 name: karyogamy involved in conjugation with cellular fusion namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh] synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000743 name: nuclear migration involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0006946 def: "The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt] synonym: "nuclear congression" BROAD [] synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0030473 ! nuclear migration along microtubule is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000744 name: karyogamy involved in conjugation with mutual genetic exchange namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei." [GOC:elh] synonym: "karyogamy involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000745 name: nuclear migration involved in conjugation with mutual genetic exchange namespace: biological_process def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah] synonym: "nuclear exchange during conjugation without cellular fusion" RELATED [] synonym: "nuclear migration involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0000744 ! karyogamy involved in conjugation with mutual genetic exchange [Term] id: GO:0000746 name: conjugation namespace: biological_process def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh] subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Conjugation is_a: GO:0051704 ! multi-organism process [Term] id: GO:0000747 name: conjugation with cellular fusion namespace: biological_process alt_id: GO:0007322 alt_id: GO:0007333 alt_id: GO:0030461 alt_id: GO:0030477 def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] subset: goslim_pombe synonym: "cell fusion" RELATED [] synonym: "mating" RELATED [] is_a: GO:0000746 ! conjugation is_a: GO:0019953 ! sexual reproduction [Term] id: GO:0000748 name: conjugation with mutual genetic exchange namespace: biological_process def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh] synonym: "conjugation without cellular fusion" EXACT [] is_a: GO:0000746 ! conjugation [Term] id: GO:0000749 name: response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007328 alt_id: GO:0030434 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph] is_a: GO:0019236 ! response to pheromone is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000750 name: pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007330 alt_id: GO:0030454 def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "transduction of mating signal" BROAD [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0032005 ! regulation of conjugation with cellular fusion by signal transduction relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000751 name: cell cycle arrest in response to pheromone namespace: biological_process alt_id: GO:0030571 def: "The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:tb] is_a: GO:0007050 ! cell cycle arrest is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000752 name: agglutination involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007334 def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh] synonym: "agglutination" BROAD [] synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT [] synonym: "cell-cell adhesion during mating" EXACT [] is_a: GO:0000771 ! agglutination involved in conjugation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000753 name: cell morphogenesis involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007332 def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt] synonym: "shmoo orientation" NARROW [] synonym: "shmooing" NARROW [] is_a: GO:0000767 ! cell morphogenesis involved in conjugation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000754 name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007331 alt_id: GO:0030453 def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt] synonym: "adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion" EXACT [GOC:mah] synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT [] is_a: GO:0000749 ! response to pheromone involved in conjugation with cellular fusion is_a: GO:0023058 ! adaptation of signaling pathway [Term] id: GO:0000755 name: cytogamy namespace: biological_process alt_id: GO:0000218 alt_id: GO:0030462 def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] synonym: "zygote formation" NARROW [] is_a: GO:0022413 ! reproductive process in single-celled organism relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000756 name: response to pheromone involved in conjugation with mutual genetic exchange namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion." [GOC:clt] synonym: "response to pheromone involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007154 ! cell communication is_a: GO:0019236 ! response to pheromone is_a: GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000757 name: signal transduction involved in conjugation with mutual genetic exchange namespace: biological_process def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt] synonym: "signal transduction involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange [Term] id: GO:0000758 name: agglutination involved in conjugation with mutual genetic exchange namespace: biological_process def: "During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh] synonym: "agglutination involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000771 ! agglutination involved in conjugation relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange [Term] id: GO:0000759 name: cell morphogenesis involved in conjugation with mutual genetic exchange namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt] synonym: "cellular morphogenesis involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000767 ! cell morphogenesis involved in conjugation relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange [Term] id: GO:0000760 name: adaptation to pheromone involved in conjugation with mutual genetic exchange namespace: biological_process def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone involved conjugation without cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT [] is_a: GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange is_a: GO:0022401 ! negative adaptation of signaling pathway [Term] id: GO:0000761 name: conjugant formation namespace: biological_process def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000762 name: pheromone-induced unidirectional conjugation namespace: biological_process def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh] is_a: GO:0009291 ! unidirectional conjugation [Term] id: GO:0000763 name: cell morphogenesis involved in unidirectional conjugation namespace: biological_process def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt] comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. is_obsolete: true [Term] id: GO:0000764 name: cellular morphogenesis involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt] comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. synonym: "cellular morphogenesis during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0000765 name: response to pheromone involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of pheromone-induced unidirectional conjugation." [GOC:clt] synonym: "response to pheromone during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] is_a: GO:0019236 ! response to pheromone relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation [Term] id: GO:0000766 name: negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone during pheromone-induced unidirectional conjugation" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT [] synonym: "negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] is_a: GO:0000765 ! response to pheromone involved in pheromone-induced unidirectional conjugation is_a: GO:0022401 ! negative adaptation of signaling pathway [Term] id: GO:0000767 name: cell morphogenesis involved in conjugation namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh] is_a: GO:0000902 ! cell morphogenesis relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" EXACT [] is_a: GO:0006949 ! syncytium formation [Term] id: GO:0000769 name: syncytium formation by mitosis without cytokinesis namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis." [GOC:mah, GOC:tb] synonym: "syncytium formation by mitosis without cell division" RELATED [GOC:mah] is_a: GO:0006949 ! syncytium formation [Term] id: GO:0000770 name: peptide pheromone export namespace: biological_process alt_id: GO:0007325 def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh] synonym: "a-factor export" NARROW [] synonym: "peptide pheromone secretion" EXACT [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0000771 name: agglutination involved in conjugation namespace: biological_process def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh] is_a: GO:0007157 ! heterophilic cell-cell adhesion relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000772 name: mating pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh] is_a: GO:0005186 ! pheromone activity [Term] id: GO:0000773 name: phosphatidyl-N-methylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71] subset: gosubset_prok synonym: "methyltransferase II" RELATED [EC:2.1.1.71] synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71] synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "PLMT" EXACT [] synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71] xref: EC:2.1.1.71 xref: MetaCyc:2.1.1.71-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000774 name: adenyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] subset: gosubset_prok is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0060590 ! ATPase regulator activity [Term] id: GO:0000775 name: chromosome, centromeric region namespace: cellular_component def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "centromere" RELATED [] synonym: "chromosome, centric region" EXACT [] synonym: "chromosome, pericentric region" RELATED [] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000776 name: kinetochore namespace: cellular_component alt_id: GO:0005699 def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] subset: goslim_pir xref: Wikipedia:Kinetochore is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0000777 name: condensed chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000776 ! kinetochore relationship: part_of GO:0000779 ! condensed chromosome, centromeric region [Term] id: GO:0000778 name: condensed nuclear chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000777 ! condensed chromosome kinetochore is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000780 ! condensed nuclear chromosome, centromeric region [Term] id: GO:0000779 name: condensed chromosome, centromeric region namespace: cellular_component def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed chromosome, centric region" EXACT [] synonym: "condensed chromosome, centromere" RELATED [] synonym: "condensed chromosome, pericentric region" RELATED [] is_a: GO:0000775 ! chromosome, centromeric region relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000780 name: condensed nuclear chromosome, centromeric region namespace: cellular_component def: "The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed nuclear chromosome, centric region" EXACT [] synonym: "condensed nuclear chromosome, centromere" RELATED [] synonym: "condensed nuclear chromosome, pericentric region" RELATED [] is_a: GO:0000779 ! condensed chromosome, centromeric region is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000781 name: chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "telomere" RELATED [] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000782 name: telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. subset: goslim_pir subset: gosubset_prok is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000781 ! chromosome, telomeric region [Term] id: GO:0000783 name: nuclear telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. is_a: GO:0000782 ! telomere cap complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region [Term] id: GO:0000784 name: nuclear chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "nuclear chromosome, telomere" EXACT [] is_a: GO:0000781 ! chromosome, telomeric region is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000785 name: chromatin namespace: cellular_component alt_id: GO:0005717 def: "The ordered and organized complex of DNA and protein that forms the chromosome." [GOC:elh] synonym: "chromosome scaffold" RELATED [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000786 name: nucleosome namespace: cellular_component alt_id: GO:0005718 def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] subset: goslim_pir xref: Wikipedia:Nucleosome is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000785 ! chromatin [Term] id: GO:0000787 name: cytoplasmic nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000789 ! cytoplasmic chromatin [Term] id: GO:0000788 name: nuclear nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0000789 name: cytoplasmic chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms the chromosome in the cytoplasm." [GOC:elh] is_a: GO:0000785 ! chromatin is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000790 name: nuclear chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms the chromosome in the nucleus." [GOC:elh] is_a: GO:0000785 ! chromatin is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000791 name: euchromatin namespace: cellular_component def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao445485807 xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component def: "A compact and highly condensed form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000793 name: condensed chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. synonym: "cytoplasmic mitotic chromosome" RELATED [] synonym: "metaphase chromosome" RELATED [] synonym: "mitotic chromosome" RELATED [] is_a: GO:0005694 ! chromosome [Term] id: GO:0000794 name: condensed nuclear chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus." [GOC:elh] comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. synonym: "meiotic chromosome" RELATED [] synonym: "nuclear mitotic chromosome" RELATED [] is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000793 ! condensed chromosome [Term] id: GO:0000795 name: synaptonemal complex namespace: cellular_component alt_id: GO:0005716 def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh] xref: Wikipedia:Synaptonemal_complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000796 name: condensin complex namespace: cellular_component alt_id: GO:0005676 alt_id: GO:0008620 def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] subset: goslim_pir synonym: "13S condensin complex" NARROW [] synonym: "SMC complex" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000797 name: condensin core heterodimer namespace: cellular_component alt_id: GO:0008621 def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] synonym: "8S condensin complex" NARROW [] synonym: "Smc2-Smc4 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000796 ! condensin complex [Term] id: GO:0000798 name: nuclear cohesin complex namespace: cellular_component def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh] comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. is_a: GO:0008278 ! cohesin complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000799 name: nuclear condensin complex namespace: cellular_component def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh] is_a: GO:0000796 ! condensin complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000800 name: lateral element namespace: cellular_component def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000801 name: central element namespace: cellular_component def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000802 name: transverse filament namespace: cellular_component def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000803 name: sex chromosome namespace: cellular_component def: "A chromosome involved in sex determination." [GOC:elh] is_a: GO:0005694 ! chromosome [Term] id: GO:0000804 name: W chromosome namespace: cellular_component def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, ISBN:0321000382] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000805 name: X chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089] xref: Wikipedia:X_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000806 name: Y chromosome namespace: cellular_component def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089] xref: Wikipedia:Y_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000807 name: Z chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, ISBN:0321000382] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000808 name: origin recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] subset: goslim_pir subset: gosubset_prok synonym: "ORC" EXACT [] synonym: "origin of replication recognition complex" EXACT [] xref: Wikipedia:Origin_recognition_complex is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000809 name: cytoplasmic origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh] subset: gosubset_prok synonym: "cytoplasmic ORC" EXACT [] synonym: "prokaryotic ORC" RELATED [] is_a: GO:0000808 ! origin recognition complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000810 name: diacylglycerol pyrophosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacylglycerol-3-phosphate + phosphate." [EC:3.1.3.-, MetaCyc:RXN-11277, PMID:8567632, PMID:9452443] synonym: "DGPP phosphatase activity" EXACT [] synonym: "DGPP phosphohydrolase activity" EXACT [] synonym: "diacylglycerol diphosphate phosphatase activity" EXACT [MetaCyc:RXN-11277] xref: EC:3.1.3.- xref: MetaCyc:RXN-11277 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000811 name: GINS complex namespace: cellular_component def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990] synonym: "Go, Ichi, Ni and San complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000812 name: Swr1 complex namespace: cellular_component def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [PMID:14645854, PMID:14690608] synonym: "SWR-C" EXACT [] is_a: GO:0016585 ! chromatin remodeling complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0000813 name: ESCRT I complex namespace: cellular_component def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000814 name: ESCRT II complex namespace: cellular_component def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000815 name: ESCRT III complex namespace: cellular_component def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000817 name: COMA complex namespace: cellular_component def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972] synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000818 name: nuclear MIS12/MIND type complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972] synonym: "MIND complex" EXACT [] synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT [] is_a: GO:0000444 ! MIS12/MIND type complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0007059 ! chromosome segregation is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization [Term] id: GO:0000820 name: regulation of glutamine family amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators] synonym: "regulation of glutamine family amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0000821 name: regulation of arginine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators] synonym: "regulation of arginine metabolism" EXACT [] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process relationship: regulates GO:0006525 ! arginine metabolic process [Term] id: GO:0000822 name: inositol hexakisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators] synonym: "InsP6 binding" EXACT [] synonym: "IP6 binding" EXACT [] is_a: GO:0043178 ! alcohol binding [Term] id: GO:0000823 name: inositol trisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol (1,4,5)-trisphosphate + ATP = D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP + 2 H+." [MetaCyc:2.7.1.151-RXN] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] xref: EC:2.7.1.151 xref: KEGG:R05800 xref: MetaCyc:2.7.1.151-RXN is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0000824 name: inositol tetrakisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "EC:2.7.1.151" BROAD [] synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000825 name: inositol tetrakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT [] synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT [] is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000826 name: inositol pyrophosphate synthase activity namespace: molecular_function def: "Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds." [GOC:elh, PMID:16429326] synonym: "inositol diphosphate synthase activity" EXACT [] is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000827 name: inositol 1,3,4,5,6-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [GOC:elh, PMID:11311242] synonym: "EC:2.7.4.21" BROAD [] is_a: GO:0000826 ! inositol pyrophosphate synthase activity [Term] id: GO:0000828 name: inositol hexakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown)." [GOC:elh, PMID:16429326] is_a: GO:0000826 ! inositol pyrophosphate synthase activity [Term] id: GO:0000829 name: inositol heptakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown." [GOC:elh, PMID:16429326] is_a: GO:0000826 ! inositol pyrophosphate synthase activity [Term] id: GO:0000830 name: inositol hexakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0033187 ! inositol hexakisphosphate 4-kinase or 6-kinase activity [Term] id: GO:0000831 name: inositol hexakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0033187 ! inositol hexakisphosphate 4-kinase or 6-kinase activity [Term] id: GO:0000832 name: inositol hexakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [MetaCyc:2.7.1.152-RXN] synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [] xref: EC:2.7.4.21 xref: MetaCyc:2.7.1.152-RXN is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000833 name: inositol heptakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326] synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT [] synonym: "IP7 4-kinase activity" EXACT [] is_a: GO:0033199 ! inositol heptakisphosphate 4-kinase or 6-kinase activity [Term] id: GO:0000834 name: inositol heptakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0033199 ! inositol heptakisphosphate 4-kinase or 6-kinase activity [Term] id: GO:0000835 name: ER ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the ER." [GOC:elh] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0000836 name: Hrd1p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000837 name: Doa10p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066] synonym: "Ssm4p ubiquitin ligase complex" EXACT [] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000838 name: Hrd1p ubiquitin ligase ERAD-M complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000839 name: Hrd1p ubiquitin ligase ERAD-L complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000900 name: translation repressor activity, nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid." [GOC:clt] is_a: GO:0030371 ! translation repressor activity is_a: GO:0090079 ! translation regulator activity, nucleic acid binding [Term] id: GO:0000901 name: translation repressor activity, non-nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt] is_a: GO:0030371 ! translation repressor activity is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_generic subset: gosubset_prok synonym: "cellular morphogenesis" EXACT [] is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0000903 name: regulation of cell shape during vegetative growth phase namespace: biological_process alt_id: GO:0090061 def: "Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators, GOC:vw] synonym: "cell morphogenesis during vegetative growth phase" RELATED [GOC:vw] synonym: "cellular morphogenesis during vegetative growth" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell morphogenesis during vegetative growth phase" RELATED [] is_a: GO:0008360 ! regulation of cell shape [Term] id: GO:0000904 name: cell morphogenesis involved in differentiation namespace: biological_process def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators] is_a: GO:0000902 ! cell morphogenesis relationship: part_of GO:0048468 ! cell development [Term] id: GO:0000905 name: sporocarp development involved in asexual reproduction namespace: biological_process def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu] synonym: "conidium development" NARROW [] synonym: "fruiting body formation involved in asexual reproduction" BROAD [] synonym: "haploid fruiting" RELATED [] synonym: "homokaryotic fruiting" RELATED [] synonym: "imperfect stage fruiting body development" NARROW [] synonym: "monokaryotic fruiting" RELATED [] is_a: GO:0030584 ! sporocarp development relationship: part_of GO:0019954 ! asexual reproduction [Term] id: GO:0000906 name: 6,7-dimethyl-8-ribityllumazine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [EC:5.4.-.-, PMID:7559556] synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] xref: EC:5.4.-.- is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0000907 name: sulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536] subset: gosubset_prok synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT [] synonym: "sulphonate dioxygenase activity" EXACT [] xref: EC:1.14.11.- is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0000908 name: taurine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite." [EC:1.14.11.17, RHEA:15912] subset: gosubset_prok synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17] xref: EC:1.14.11.17 xref: KEGG:R05320 xref: MetaCyc:RXN0-299 xref: RHEA:15912 is_a: GO:0000907 ! sulfonate dioxygenase activity [Term] id: GO:0000909 name: sporocarp development involved in sexual reproduction namespace: biological_process def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu] synonym: "ascus development" NARROW [] synonym: "fruiting body development involved in sexual reproduction" BROAD [] synonym: "fruiting body formation involved in sexual reproduction" BROAD [] synonym: "perfect stage fruiting body development" NARROW [] is_a: GO:0030584 ! sporocarp development relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0000910 name: cytokinesis namespace: biological_process alt_id: GO:0007104 alt_id: GO:0016288 def: "A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GOC:ai] comment: Note that most eukaryotic gene products involved in canonical cytokinesis during the cell cycle can be annotated to 'cell cycle cytokinesis ; GO:0033205' or its descendants. See also 'cell division ; GO:0051301'. Note that cytokinesis excludes nuclear division; in prokaryotes, there is little difference between cytokinesis and cell division. subset: goslim_candida subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok xref: Reactome:1253275 "Mitotic Telophase /Cytokinesis" xref: Reactome:1280211 "Mitotic Telophase /Cytokinesis" xref: Reactome:1326787 "Mitotic Telophase /Cytokinesis" xref: Reactome:1352890 "Mitotic Telophase /Cytokinesis" xref: Reactome:1373096 "Mitotic Telophase /Cytokinesis" xref: Reactome:1393112 "Mitotic Telophase /Cytokinesis" xref: Reactome:1417598 "Mitotic Telophase /Cytokinesis" xref: Reactome:1450689 "Mitotic Telophase /Cytokinesis" xref: Reactome:1471153 "Mitotic Telophase /Cytokinesis" xref: Reactome:1483156 "Mitotic Telophase /Cytokinesis" xref: Reactome:1521110 "Mitotic Telophase /Cytokinesis" xref: Reactome:1532602 "Mitotic Telophase /Cytokinesis" xref: Reactome:68884 "Mitotic Telophase /Cytokinesis" xref: Wikipedia:Cytokinesis is_a: GO:0009987 ! cellular process relationship: part_of GO:0051301 ! cell division [Term] id: GO:0000911 name: cytokinesis by cell plate formation namespace: biological_process def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt] is_a: GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000912 name: assembly of actomyosin apparatus involved in cell cycle cytokinesis namespace: biological_process def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:mah] synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah] synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb] synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph] is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0032506 ! cytokinetic process is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000913 name: preprophase band assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah] synonym: "preprophase band formation" RELATED [GOC:mah] is_a: GO:0007105 ! cytokinesis, site selection is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000914 name: phragmoplast assembly namespace: biological_process def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt] synonym: "phragmoplast formation" RELATED [goc:dph] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cell cycle cytokinesis relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000915 name: cytokinesis, actomyosin contractile ring assembly namespace: biological_process alt_id: GO:0045573 def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] synonym: "constriction ring assembly" NARROW [] synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED [] synonym: "cytokinesis, actomyosin ring formation" RELATED [] synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cell cycle cytokinesis [Term] id: GO:0000916 name: contractile ring contraction involved in cell cycle cytokinesis namespace: biological_process def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] synonym: "contractile ring constriction" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin ring contraction" EXACT [] synonym: "cytokinesis, contractile ring contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000917 name: barrier septum formation namespace: biological_process def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material." [GOC:clt, GOC:mah] synonym: "barrier septum assembly" EXACT [GOC:mah] synonym: "formation of barrier septum" EXACT [] synonym: "septation" BROAD [] synonym: "septin assembly and septum biosynthesis" RELATED [] synonym: "septin assembly and septum formation" RELATED [] is_a: GO:0032506 ! cytokinetic process is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0000918 name: barrier septum site selection namespace: biological_process def: "The process of marking the site where a barrier septum will form." [GOC:clt] synonym: "selection of site for barrier cell septum biosynthesis" EXACT [] synonym: "selection of site for barrier cell septum formation" EXACT [] synonym: "selection of site for barrier septum formation" EXACT [GOC:curators] synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] synonym: "septum positioning" EXACT [] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000917 ! barrier septum formation [Term] id: GO:0000919 name: cell plate assembly namespace: biological_process def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt] synonym: "cell plate formation" RELATED [GOC:mah] is_a: GO:0032506 ! cytokinetic process is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000920 name: cytokinetic cell separation namespace: biological_process def: "The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:clt] synonym: "cell separation during cytokinesis" RELATED [GOC:dph, GOC:tb] synonym: "rotokinesis" NARROW [] is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0000921 name: septin ring assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt] subset: gosubset_prok synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0031106 ! septin ring organization [Term] id: GO:0000922 name: spindle pole namespace: cellular_component alt_id: GO:0030615 def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle [Term] id: GO:0000923 name: equatorial microtubule organizing center namespace: cellular_component def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817] synonym: "EMTOC" EXACT [] synonym: "equatorial microtubule organising centre" EXACT [] is_a: GO:0005815 ! microtubule organizing center is_a: GO:0032155 ! cell division site part [Term] id: GO:0000924 name: gamma-tubulin ring complex, centrosomal namespace: cellular_component alt_id: GO:0000925 alt_id: GO:0000926 def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256] synonym: "gamma-tubulin large complex, centrosomal" EXACT [] is_a: GO:0008274 ! gamma-tubulin ring complex relationship: part_of GO:0000242 ! pericentriolar material [Term] id: GO:0000927 name: gamma-tubulin small complex, centrosomal namespace: cellular_component def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0008275 ! gamma-tubulin small complex [Term] id: GO:0000928 name: gamma-tubulin small complex, spindle pole body namespace: cellular_component def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:mtg_sensu, PMID:12134075] synonym: "Tub4 complex" EXACT [] is_a: GO:0008275 ! gamma-tubulin small complex relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0000930 name: gamma-tubulin complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044450 ! microtubule organizing center part [Term] id: GO:0000931 name: gamma-tubulin large complex namespace: cellular_component alt_id: GO:0000929 def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0000930 ! gamma-tubulin complex [Term] id: GO:0000932 name: cytoplasmic mRNA processing body namespace: cellular_component def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] synonym: "cytoplasmic foci" RELATED [] synonym: "P body" EXACT [] synonym: "P-body" EXACT [] xref: Wikipedia:P_body is_a: GO:0035770 ! RNA granule [Term] id: GO:0000933 name: adventitious septum namespace: cellular_component def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526] is_a: GO:0030428 ! cell septum [Term] id: GO:0000934 name: porous cell septum namespace: cellular_component def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt] synonym: "porous septum" BROAD [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000935 name: barrier septum namespace: cellular_component def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt] synonym: "complete septum" EXACT [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000936 name: primary cell septum namespace: cellular_component def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526] synonym: "primary septum" BROAD [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000937 name: dolipore septum namespace: cellular_component def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt] is_a: GO:0000934 ! porous cell septum [Term] id: GO:0000938 name: GARP complex namespace: cellular_component def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] synonym: "Golgi associated retrograde protein complex" EXACT [] synonym: "VFT tethering complex" EXACT [] synonym: "Vps fifty three tethering complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0000939 name: condensed chromosome inner kinetochore namespace: cellular_component def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983] synonym: "inner centromere core complex" RELATED [] synonym: "inner kinetochore of condensed chromosome" EXACT [GOC:curators] synonym: "inner kinetochore plate" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000940 name: condensed chromosome outer kinetochore namespace: cellular_component def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983] synonym: "outer kinetochore of condensed chromosome" EXACT [GOC:curators] synonym: "outer kinetochore plate" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000941 name: condensed nuclear chromosome inner kinetochore namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398] synonym: "inner kinetochore of condensed nuclear chromosome" EXACT [GOC:curators] is_a: GO:0000939 ! condensed chromosome inner kinetochore is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000942 name: condensed nuclear chromosome outer kinetochore namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398] synonym: "outer kinetochore of condensed nuclear chromosome" EXACT [GOC:curators] is_a: GO:0000940 ! condensed chromosome outer kinetochore is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000943 name: retrotransposon nucleocapsid namespace: cellular_component def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903] synonym: "Virus-like particle" EXACT [] synonym: "VLP" EXACT [] xref: Wikipedia:Virus-like_particle is_a: GO:0044428 ! nuclear part [Term] id: GO:0000944 name: base pairing with rRNA namespace: molecular_function def: "Interacting selectively and non-covalently with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000498 ! base pairing with RNA is_a: GO:0019843 ! rRNA binding [Term] id: GO:0000945 name: base pairing with snRNA namespace: molecular_function def: "Interacting selectively and non-covalently with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000498 ! base pairing with RNA is_a: GO:0017069 ! snRNA binding [Term] id: GO:0000946 name: base pairing with tRNA namespace: molecular_function def: "Interacting selectively and non-covalently with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000049 ! tRNA binding is_a: GO:0000498 ! base pairing with RNA [Term] id: GO:0000947 name: amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0000948 name: amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0000949 name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000950 name: branched chain family amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0000951 name: methionine catabolic process to 3-methylthiopropanol namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0000952 name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000953 name: branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0000954 name: methionine catabolic process to 3-methylthiopropanoate namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0000955 name: amino acid catabolic process via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0009063 ! cellular amino acid catabolic process [Term] id: GO:0000956 name: nuclear-transcribed mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] synonym: "nuclear mRNA breakdown" EXACT [] synonym: "nuclear mRNA catabolism" EXACT [] synonym: "nuclear mRNA degradation" EXACT [] is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000957 name: mitochondrial RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0000958 name: mitochondrial mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000957 ! mitochondrial RNA catabolic process is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000959 name: mitochondrial RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0000960 name: regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000961 name: negative regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0051253 ! negative regulation of RNA metabolic process relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000962 name: positive regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000963 name: mitochondrial RNA processing namespace: biological_process def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006396 ! RNA processing [Term] id: GO:0000964 name: mitochondrial RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 5' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0000966 ! RNA 5'-end processing [Term] id: GO:0000965 name: mitochondrial RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 3' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0031123 ! RNA 3'-end processing [Term] id: GO:0000966 name: RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc] synonym: "RNA 5' end processing" EXACT [] is_a: GO:0006396 ! RNA processing [Term] id: GO:0000967 name: rRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc] synonym: "rRNA 5' end processing" EXACT [] is_a: GO:0034471 ! ncRNA 5'-end processing [Term] id: GO:0000968 name: tRNA exon ligation namespace: biological_process def: "An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed." [GOC:krc] is_a: GO:0000378 ! RNA exon ligation relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000969 name: tRNA exon ligation utilizing ATP as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051] is_a: GO:0000968 ! tRNA exon ligation [Term] id: GO:0000970 name: tRNA exon ligation utilizing GTP as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation [Term] id: GO:0000971 name: tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation [Term] id: GO:0000972 name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0000973 name: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049] is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Term] id: GO:0000974 name: Prp19 complex namespace: cellular_component def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890] synonym: "nineteen complex" NARROW [] synonym: "NTC" RELATED [] synonym: "Prp19/CDC5 complex" NARROW [] is_a: GO:0043234 ! protein complex [Term] id: GO:0000975 name: regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0001067 ! regulatory region nucleic acid binding is_a: GO:0003677 ! DNA binding [Term] id: GO:0000976 name: transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0043565 ! sequence-specific DNA binding is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0000977 name: RNA polymerase II regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001012 ! RNA polymerase II regulatory region DNA binding [Term] id: GO:0000978 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding [Term] id: GO:0000979 name: RNA polymerase II core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery." [GOC:txnOH] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding [Term] id: GO:0000980 name: RNA polymerase II enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001158 ! enhancer sequence-specific DNA binding [Term] id: GO:0000981 name: sequence-specific DNA binding RNA polymerase II transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0000982 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:txnOH] is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0000983 name: RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0000984 name: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". subset: gosubset_prok synonym: "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding" RELATED [] is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001017 ! bacterial-type RNA polymerase regulatory region DNA binding [Term] id: GO:0000985 name: bacterial-type RNA polymerase core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in a bacterial-type RNA polymerase core promoter, the region composed of the transcription start site and binding sites for transcription factors of the basal transcription machinery, in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] subset: gosubset_prok synonym: "bacterial-type RNA polymerase core promoter sequence-specific DNA binding" EXACT [] synonym: "eubacterial-type RNA polymerase core promoter sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding [Term] id: GO:0000986 name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase." [GOC:txnOH] subset: gosubset_prok synonym: "eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding [Term] id: GO:0000987 name: core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001159 ! core promoter proximal region DNA binding [Term] id: GO:0000988 name: protein binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0003674 ! molecular_function [Term] id: GO:0000989 name: transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0000988 ! protein binding transcription factor activity [Term] id: GO:0000990 name: core RNA polymerase binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription." [GOC:txnOH] is_a: GO:0000988 ! protein binding transcription factor activity [Term] id: GO:0000991 name: core RNA polymerase II binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription by Pol II." [GOC:txnOH] is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity [Term] id: GO:0000992 name: polymerase III regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes." [GOC:txnOH, PMID:12381659] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0000993 name: RNA polymerase II core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH] is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0000994 name: RNA polymerase III core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0000995 name: core RNA polymerase III binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, in order to modulate transcription by Pol III." [GOC:txnOH, PMID:12381659] is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity [Term] id: GO:0000996 name: core RNA polymerase binding promoter specificity activity namespace: molecular_function def: "An activity that binds to RNA polymerase and which while present in a complex with the core RNA polymerase confers sequence specific recognition of promoter DNA sequence motifs." [GOC:txnOH] is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity [Term] id: GO:0000997 name: mitochondrial RNA polymerase core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of the core promoter for the mitochondrial RNA polymerase." [GOC:txnOH] is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding [Term] id: GO:0000999 name: RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 1 promoters require TFIIIA for promoter recognition, which then recruits TFIIIC. TFIIIC in turn recruits TFIIIB, which recruits Pol III to the promoter." [GOC:txnOH, PMID:12381659] is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly relationship: part_of GO:0001022 ! transcription initiation from RNA polymerase III type 1 promoter [Term] id: GO:0001000 name: bacterial-type RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit." [GOC:txnOH] comment: Should omega be included here? subset: gosubset_prok synonym: "eubacterial-type RNA polymerase core enzyme binding" EXACT [] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001001 name: mitochondrial single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995, PMID:2088182] is_a: GO:0001050 ! single-subunit type RNA polymerase binding [Term] id: GO:0001002 name: RNA polymerase III type 1 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001030 ! RNA polymerase III type 1 promoter DNA binding [Term] id: GO:0001003 name: RNA polymerase III type 2 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001031 ! RNA polymerase III type 2 promoter DNA binding [Term] id: GO:0001004 name: RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in an RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter." [GOC:txnOH, PMID:12381659] is_a: GO:0001010 ! sequence-specific DNA binding transcription factor recruiting transcription factor activity is_a: GO:0001034 ! sequence-specific DNA binding RNA polymerase III transcription factor activity is_a: GO:0001153 ! RNA polymerase III transcription factor recruiting transcription factor activity [Term] id: GO:0001005 name: RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC." [GOC:txnOH, PMID:12381659] comment: This represents TFIIIA. synonym: "TFIIIA activity" RELATED [] synonym: "TFIIIC-type activity" RELATED [] is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [Term] id: GO:0001006 name: RNA polymerase III type 3 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001032 ! RNA polymerase III type 3 promoter DNA binding [Term] id: GO:0001007 name: RNA polymerase III transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0001008 name: RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence motif in a type 2 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 2 Pol III promoters, this requires TFIIIC activity." [GOC:txnOH, PMID:12381659] synonym: "TFIIIC-type activity" RELATED [] synonym: "type 2 RNA polymerase III promoter recognition" EXACT [] is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [Term] id: GO:0001009 name: transcription from RNA polymerase III type 2 promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 2 RNAP III promoter. Type 2 RNAP III promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0001010 name: sequence-specific DNA binding transcription factor recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions." [GOC:txnOH] is_a: GO:0001134 ! transcription factor recruiting transcription factor activity is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001011 name: sequence-specific DNA binding RNA polymerase recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC)." [GOC:txnOH] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001012 name: RNA polymerase II regulatory region DNA binding namespace: molecular_function def: "Interacting selectively with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001013 name: RNA polymerase I regulatory region DNA binding namespace: molecular_function def: "Interacting selectively with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001014 name: snoRNA transcription from a type 2 RNA polymerase III promoter namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter." [GOC:txnOH] is_a: GO:0001009 ! transcription from RNA polymerase III type 2 promoter is_a: GO:0009302 ! snoRNA transcription [Term] id: GO:0001015 name: snoRNA transcription from an RNA polymerase II promoter namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0006366 ! transcription from RNA polymerase II promoter is_a: GO:0009302 ! snoRNA transcription [Term] id: GO:0001016 name: RNA polymerase III regulatory region DNA binding namespace: molecular_function def: "Interacting selectively with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, PMID:12381659] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001017 name: bacterial-type RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] subset: gosubset_prok synonym: "eubacterial-type RNA polymerase regulatory region DNA binding" EXACT [] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001018 name: mitochondrial RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively with a DNA region that controls the transcription of a region of DNA by mitochondrial RNA polymerase. Binding may occur as a high affinity and sequence specific interaction or as a lower affinity interaction observed once a factor has been recruited to the DNA by other factors." [GOC:txnOH, PMID:20056105] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001019 name: plastid RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively with a DNA region that controls the transcription of a region of DNA by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001020 name: RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription." [GOC:txnOH, PMID:12381659] is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly relationship: part_of GO:0001024 ! transcription initiation from RNA polymerase III type 3 promoter [Term] id: GO:0001021 name: RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a type 2 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 2 promoters require TFIIIC for promoter recognition, which then recruits TFIIIB, which in turn which recruits Pol III to the promoter." [GOC:txnOH, PMID:12381659] is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly relationship: part_of GO:0001023 ! transcription initiation from RNA polymerase III type 2 promoter [Term] id: GO:0001022 name: transcription initiation from RNA polymerase III type 1 promoter namespace: biological_process def: "A transcription initiation process on a type 1 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter relationship: part_of GO:0042791 ! 5S class rRNA transcription from RNA polymerase III type 1 promoter [Term] id: GO:0001023 name: transcription initiation from RNA polymerase III type 2 promoter namespace: biological_process def: "A transcription initiation process on a type 2 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter relationship: part_of GO:0001009 ! transcription from RNA polymerase III type 2 promoter [Term] id: GO:0001024 name: transcription initiation from RNA polymerase III type 3 promoter namespace: biological_process def: "A transcription initiation process on a type 3 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter relationship: part_of GO:0001035 ! transcription from RNA polymerase III type 3 promoter [Term] id: GO:0001025 name: RNA polymerase III transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III." [GOC:txnOH] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0001026 name: TFIIIB-type transcription factor activity namespace: molecular_function def: "Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH] synonym: "RNA polymerase III recruiting transcription factor activity" EXACT [] is_a: GO:0000995 ! core RNA polymerase III binding transcription factor activity is_a: GO:0001007 ! RNA polymerase III transcription factor binding transcription factor activity [Term] id: GO:0001027 name: RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] synonym: "RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity" RELATED [] is_a: GO:0001026 ! TFIIIB-type transcription factor activity [Term] id: GO:0001028 name: RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] synonym: "RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity" RELATED [] is_a: GO:0001026 ! TFIIIB-type transcription factor activity [Term] id: GO:0001029 name: RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] synonym: "RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity" RELATED [] is_a: GO:0001026 ! TFIIIB-type transcription factor activity [Term] id: GO:0001030 name: RNA polymerase III type 1 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001031 name: RNA polymerase III type 2 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001032 name: RNA polymerase III type 3 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001033 name: RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in a type 3 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 3 Pol III promoters, this requires SNAPc activity." [GOC:txnOH, PMID:12381659] comment: This represents TFIIIC. synonym: "SNAPc-type activity" RELATED [] synonym: "type 3 RNA polymerase III promoter recognition" EXACT [] is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [Term] id: GO:0001034 name: sequence-specific DNA binding RNA polymerase III transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase III. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:12381659] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001035 name: transcription from RNA polymerase III type 3 promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 3 RNAP III promoter. A type 3 RNAP III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] synonym: "U6 snRNA transcription (mammalian)" NARROW [] is_a: GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0001036 name: transcription initiation from RNA polymerase III hybrid type promoter namespace: biological_process def: "A transcription initiation process on a hybrid type RNA polymerase III (Pol III) that results in RNA synthesis by Pol III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter relationship: part_of GO:0001041 ! transcription from a RNA polymerase III hybrid type promoter [Term] id: GO:0001037 name: RNA polymerase III hybrid type promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a hybrid promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001038 name: RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity namespace: molecular_function def: "Once recruited to an RNA polymerase III hybrid type promoter by sequence-specific DNA binding transcription factors, direct DNA binding, or a combination of both, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [Term] id: GO:0001039 name: RNA polymerase III hybrid type promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001037 ! RNA polymerase III hybrid type promoter DNA binding [Term] id: GO:0001040 name: RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] is_a: GO:0001026 ! TFIIIB-type transcription factor activity [Term] id: GO:0001041 name: transcription from a RNA polymerase III hybrid type promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at a hybrid type RNA polymerase III (RNAP III) promoter. A hybrid RNAP III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] synonym: "U2 snRNA transcription (S. cerevisiae)" NARROW [] is_a: GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0001042 name: RNA polymerase I core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001043 name: RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a hybrid type RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Hybrid type promoters contain both gene-internal and upstream elements. An example of a hybrid promoter is the U6 snRNA gene." [GOC:txnOH, PMID:12381659] is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly [Term] id: GO:0001044 name: mitochondrial RNA polymerase regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that controls the transcription of a region of DNA by mitochondrial RNA polymerase." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001018 ! mitochondrial RNA polymerase regulatory region DNA binding [Term] id: GO:0001045 name: mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase." [GOC:txnOH, PMID:20670382] is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding [Term] id: GO:0001046 name: core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001047 ! core promoter binding [Term] id: GO:0001047 name: core promoter binding namespace: molecular_function def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001048 name: RNA polymerase IV core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production." [GOC:txnOH, PMID:19110459] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001049 name: RNA polymerase V core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing." [GOC:txnOH, PMID:19110459] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001050 name: single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] synonym: "SP6-type RNA polymerase binding" EXACT [] synonym: "T3-type RNA polymerase binding" EXACT [] synonym: "T3/T7 type RNA polymerase binding" EXACT [] synonym: "T7-type RNA polymerase binding" EXACT [] is_a: GO:0070063 ! RNA polymerase binding [Term] id: GO:0001051 name: plastid single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] is_a: GO:0001050 ! single-subunit type RNA polymerase binding [Term] id: GO:0001052 name: plastid PEP RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit." [GOC:txnOH, PMID:20701995] is_a: GO:0001000 ! bacterial-type RNA polymerase core enzyme binding [Term] id: GO:0001053 name: plastid sigma factor activity namespace: molecular_function def: "A sigma factor that binds to the plastid PEP core RNA polymerase enzyme to confer promoter specificity." [GOC:txnOH, PMID:20701995] subset: gosubset_prok synonym: "sigma transcription factor" RELATED [] is_a: GO:0016987 ! sigma factor activity [Term] id: GO:0001054 name: RNA polymerase I activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001055 name: RNA polymerase II activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001056 name: RNA polymerase III activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001057 name: RNA polymerase IV activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001058 name: RNA polymerase V activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001059 name: transcription from RNA polymerase IV promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase IV (Pol III), originating at a Pol IV-specific promoter." [GOC:txnOH, PMID:19110459] synonym: "transcription from RNA pol IV promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0001060 name: transcription from RNA polymerase V promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase V (Pol III), originating at a Pol V-specific promoter." [GOC:txnOH, PMID:19110459] synonym: "transcription from RNA pol V promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0001061 name: bacterial-type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001062 name: plastid PEP-A RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001061 ! bacterial-type RNA polymerase activity [Term] id: GO:0001063 name: plastid PEP-B RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001061 ! bacterial-type RNA polymerase activity [Term] id: GO:0001064 name: single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "T3/T7 type RNA polymerase activity" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001065 name: mitochondrial single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type mitochondrial RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] is_a: GO:0001064 ! single subunit type RNA polymerase activity [Term] id: GO:0001066 name: plastid single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001064 ! single subunit type RNA polymerase activity [Term] id: GO:0001067 name: regulatory region nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0001068 name: transcription regulatory region RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0001069 ! regulatory region RNA binding [Term] id: GO:0001069 name: regulatory region RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0001067 ! regulatory region nucleic acid binding is_a: GO:0003723 ! RNA binding [Term] id: GO:0001070 name: RNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:8332211] is_a: GO:0001071 ! nucleic acid binding transcription factor activity [Term] id: GO:0001071 name: nucleic acid binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0003674 ! molecular_function [Term] id: GO:0001072 name: RNA binding transcription antitermination factor activity namespace: molecular_function def: "Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein." [GOC:txnOH, PMID:8332211] subset: gosubset_prok is_a: GO:0001070 ! RNA binding transcription factor activity [Term] id: GO:0001073 name: DNA binding transcription antitermination factor activity namespace: molecular_function def: "Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein." [GOC:txnOH, PMID:8332211] subset: gosubset_prok is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001074 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [Term] id: GO:0001075 name: sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0000983 ! RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [Term] id: GO:0001076 name: RNA polymerase II transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0001077 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [Term] id: GO:0001078 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [Term] id: GO:0001079 name: nitrogen catabolite regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0090293 ! nitrogen catabolite regulation of transcription [Term] id: GO:0001080 name: nitrogen catabolite activation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0090294 ! nitrogen catabolite activation of transcription [Term] id: GO:0001081 name: nitrogen catabolite repression of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0090295 ! nitrogen catabolite repression of transcription [Term] id: GO:0001082 name: RNA polymerase I transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase I transcription factor in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0001083 name: RNA polymerase II basal transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity [Term] id: GO:0001084 name: TFIID-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001085 name: RNA polymerase II transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0001086 name: TFIIA-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001087 name: TFIIB-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001088 name: TFIIE-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001089 name: TFIIF-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001090 name: TFIIH-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001091 name: RNA polymerase II basal transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867] is_a: GO:0001085 ! RNA polymerase II transcription factor binding is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding [Term] id: GO:0001092 name: TFIIA-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001093 name: TFIIB-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001094 name: TFIID-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001095 name: TFIIE-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001096 name: TFIIF-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001097 name: TFIIH-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001098 name: basal transcription machinery binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. is_a: GO:0005515 ! protein binding [Term] id: GO:0001099 name: basal RNA polymerase II transcription machinery binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. is_a: GO:0001098 ! basal transcription machinery binding [Term] id: GO:0001100 name: negative regulation of exit from mitosis namespace: biological_process def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn] synonym: "down regulation of exit from mitosis" EXACT [] synonym: "down-regulation of exit from mitosis" EXACT [] synonym: "downregulation of exit from mitosis" EXACT [] synonym: "inhibition of exit from mitosis" NARROW [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0010948 ! negative regulation of cell cycle process relationship: negatively_regulates GO:0010458 ! exit from mitosis [Term] id: GO:0001101 name: response to acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus." [GOC:rn] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0001102 name: RNA polymerase II activating transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH] is_a: GO:0001085 ! RNA polymerase II transcription factor binding is_a: GO:0033613 ! activating transcription factor binding [Term] id: GO:0001103 name: RNA polymerase II repressing transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH] is_a: GO:0001085 ! RNA polymerase II transcription factor binding is_a: GO:0070491 ! repressing transcription factor binding [Term] id: GO:0001104 name: RNA polymerase II transcription cofactor activity namespace: molecular_function alt_id: GO:0016455 def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] subset: gosubset_prok synonym: "RNA polymerase II transcription mediator activity" RELATED [] synonym: "RNA polymerase II transcriptional co-regulator" EXACT [] synonym: "RNA polymerase II transcriptional cofactor activity" EXACT [] synonym: "thyroid receptor-associated protein" RELATED [] synonym: "TRAP protein" RELATED [] is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity is_a: GO:0003712 ! transcription cofactor activity [Term] id: GO:0001105 name: RNA polymerase II transcription coactivator activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor. subset: gosubset_prok synonym: "RNA polymerase II transcription co-activator activity" EXACT [] is_a: GO:0001104 ! RNA polymerase II transcription cofactor activity is_a: GO:0003713 ! transcription coactivator activity [Term] id: GO:0001106 name: RNA polymerase II transcription corepressor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] synonym: "RNA polymerase II transcription co-repressor activity" EXACT [] is_a: GO:0001104 ! RNA polymerase II transcription cofactor activity is_a: GO:0003714 ! transcription corepressor activity [Term] id: GO:0001108 name: bacterial-type RNA polymerase holo enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase." [GOC:txnOH] subset: gosubset_prok synonym: "basal bacterial-type RNA polymerase transcription machinery binding" EXACT [] is_a: GO:0001098 ! basal transcription machinery binding [Term] id: GO:0001109 name: promoter clearance during DNA-dependent transcription namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "promoter escape" BROAD [] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0001110 name: promoter clearance from RNA polymerase III promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase." [GOC:txnOH] is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0001111 name: promoter clearance from RNA polymerase II promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047] synonym: "promoter escape from RNA polymerase II promoter" EXACT [] is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0001112 name: DNA-dependent transcriptional open complex formation namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "promoter melting" BROAD [] is_a: GO:0001120 ! protein-DNA complex remodeling relationship: part_of GO:0006352 ! transcription initiation, DNA-dependent [Term] id: GO:0001113 name: transcriptional open complex formation at RNA polymerase II promoter namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "RNA polymerase II promoter melting" EXACT [] is_a: GO:0001112 ! DNA-dependent transcriptional open complex formation relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0001114 name: protein-DNA-RNA complex namespace: cellular_component def: "A macromolecular complex containing protein, DNA, and RNA molecules." [GOC:txnOH] is_a: GO:0032991 ! macromolecular complex [Term] id: GO:0001115 name: protein-DNA-RNA complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex." [GOC:txnOH] is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0001116 name: protein-DNA-RNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0034622 ! cellular macromolecular complex assembly [Term] id: GO:0001117 name: protein-DNA-RNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-DNA-RNA complex into its constituent components." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0034623 ! cellular macromolecular complex disassembly [Term] id: GO:0001118 name: transcription ternary complex disassembly namespace: biological_process def: "The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components." [GOC:txnOH] synonym: "transcription protein-DNA-RNA complex disassembly" EXACT [] is_a: GO:0001117 ! protein-DNA-RNA complex disassembly relationship: part_of GO:0006353 ! transcription termination, DNA-dependent [Term] id: GO:0001119 name: protein-DNA-RNA complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0034367 ! macromolecular complex remodeling [Term] id: GO:0001120 name: protein-DNA complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:txnOH] is_a: GO:0034367 ! macromolecular complex remodeling is_a: GO:0071824 ! protein-DNA complex subunit organization [Term] id: GO:0001121 name: transcription from bacterial-type RNA polymerase promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter." [GOC:txnOH] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0001122 name: promoter clearance from bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor." [GOC:txnOH, PMID:18280161] is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter [Term] id: GO:0001123 name: transcription initiation from bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:txnOH, PMID:18280161] is_a: GO:0006352 ! transcription initiation, DNA-dependent relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter [Term] id: GO:0001124 name: transcription elongation from bacterial-type RNA polymerase promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] synonym: "RNA elongation from bacterial-type RNA polymerase promoter" EXACT [] is_a: GO:0006354 ! transcription elongation, DNA-dependent relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter [Term] id: GO:0001125 name: transcription termination from bacterial-type RNA polymerase promoter namespace: biological_process def: "The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed." [GOC:txnOH, PMID:18280161] is_a: GO:0006353 ! transcription termination, DNA-dependent relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter [Term] id: GO:0001126 name: bacterial-type RNA polymerase preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:18280161] synonym: "bacterial-type RNA polymerase transcription PIC biosynthesis" EXACT [] synonym: "bacterial-type RNA polymerase transcription PIC formation" EXACT [] synonym: "bacterial-type RNA polymerase transcriptional preinitiation complex formation" EXACT [] is_a: GO:0070897 ! DNA-dependent transcriptional preinitiation complex assembly relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter [Term] id: GO:0001127 name: transcriptional open complex formation at bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:18280161] is_a: GO:0001112 ! DNA-dependent transcriptional open complex formation relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter [Term] id: GO:0001128 name: RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:16858867] comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor. is_a: GO:0001105 ! RNA polymerase II transcription coactivator activity [Term] id: GO:0001129 name: TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] comment: For example, both TFIIA as well as TFIIB interact with TBP bound to DNA to stabilize formation of the preinitiation complex. synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" NARROW [] is_a: GO:0001132 ! TBP-class protein binding RNA polymerase II transcription factor activity [Term] id: GO:0001130 name: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001131 name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity [Term] id: GO:0001132 name: TBP-class protein binding RNA polymerase II transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH, PMID:16858867] synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity" NARROW [] synonym: "TRF protein binding RNA polymerase II transcription factor activity" NARROW [] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001133 name: sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001010 ! sequence-specific DNA binding transcription factor recruiting transcription factor activity [Term] id: GO:0001134 name: transcription factor recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription." [GOC:txnOH, PMID:16858867] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0001135 name: RNA polymerase II transcription factor recruiting transcription factor activity namespace: molecular_function def: "The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001134 ! transcription factor recruiting transcription factor activity [Term] id: GO:0001136 name: TFIIE-class transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIE-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001088 ! TFIIE-class binding transcription factor activity is_a: GO:0001135 ! RNA polymerase II transcription factor recruiting transcription factor activity [Term] id: GO:0001137 name: TFIIF-class transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIF-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001089 ! TFIIF-class binding transcription factor activity is_a: GO:0001135 ! RNA polymerase II transcription factor recruiting transcription factor activity [Term] id: GO:0001138 name: TFIIH-class transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIH-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001090 ! TFIIH-class binding transcription factor activity is_a: GO:0001135 ! RNA polymerase II transcription factor recruiting transcription factor activity [Term] id: GO:0001139 name: core RNA polymerase II recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] is_a: GO:0000991 ! core RNA polymerase II binding transcription factor activity [Term] id: GO:0001140 name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:20491932, PMID:20629756] is_a: GO:0001131 ! bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity [Term] id: GO:0001141 name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to stop, prevent, or reduce the frequency, rate or extent of transcription from a bacterial-type RNA polymerase promoter." [GOC:txnOH, PMID:20491932, PMID:20629756] is_a: GO:0001131 ! bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity [Term] id: GO:0001142 name: sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001143 name: mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence that is part of the core promoter for mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175] is_a: GO:0001142 ! sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity [Term] id: GO:0001144 name: mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175] is_a: GO:0001142 ! sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity [Term] id: GO:0001145 name: mitochondrial RNA polymerase termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase." [GOC:txnOH, PMID:18391175] is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding [Term] id: GO:0001146 name: mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase in order to promote transcription termination by mitochondrial RNA polymerase." [GOC:txnOH, PMID:18391175] is_a: GO:0001142 ! sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity [Term] id: GO:0001147 name: transcription termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH, PMID:18280161, PMID:18391175] comment: Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation. is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001160 ! transcription termination site DNA binding [Term] id: GO:0001148 name: bacterial-type RNA polymerase termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding [Term] id: GO:0001149 name: bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity [Term] id: GO:0001150 name: bacterial-type RNA polymerase enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is an enhancer region that helps activate transcription of a gene or operon by a bacterial-type RNA polymerase. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences." [GOC:txnOH, PMID:20629756] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001158 ! enhancer sequence-specific DNA binding [Term] id: GO:0001151 name: bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a bacterial-type enhancer region in order to activate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences." [GOC:txnOH, PMID:20629756] is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity [Term] id: GO:0001152 name: RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter." [GOC:txnOH, PMID:12381659] comment: This represents TFIIIA. synonym: "TFIIIA activity" RELATED [] synonym: "type 1 RNA polymerase III promoter recognition" EXACT [] is_a: GO:0001010 ! sequence-specific DNA binding transcription factor recruiting transcription factor activity is_a: GO:0001153 ! RNA polymerase III transcription factor recruiting transcription factor activity [Term] id: GO:0001153 name: RNA polymerase III transcription factor recruiting transcription factor activity namespace: molecular_function def: "The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III." [GOC:txnOH] is_a: GO:0001134 ! transcription factor recruiting transcription factor activity [Term] id: GO:0001154 name: TFIIIB-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] is_a: GO:0001025 ! RNA polymerase III transcription factor binding [Term] id: GO:0001155 name: TFIIIA-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at type 1 promoters (5S genes) by RNA polymerase III." [GOC:txnOH, PMID:12381659] is_a: GO:0001025 ! RNA polymerase III transcription factor binding [Term] id: GO:0001156 name: TFIIIC-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] is_a: GO:0001025 ! RNA polymerase III transcription factor binding [Term] id: GO:0001157 name: RNA polymerase III type 1 promoter TFIIIB recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC." [GOC:txnOH, PMID:12381659] comment: This represents TFIIIA. synonym: "TFIIIC-type activity" RELATED [] is_a: GO:0001153 ! RNA polymerase III transcription factor recruiting transcription factor activity [Term] id: GO:0001158 name: enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH] is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0035326 ! enhancer binding [Term] id: GO:0001159 name: core promoter proximal region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001160 name: transcription termination site DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001161 name: intronic transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] is_a: GO:0044213 ! intronic transcription regulatory region DNA binding [Term] id: GO:0001162 name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001161 ! intronic transcription regulatory region sequence-specific DNA binding [Term] id: GO:0001163 name: RNA polymerase I regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH] is_a: GO:0001013 ! RNA polymerase I regulatory region DNA binding [Term] id: GO:0001164 name: RNA polymerase I core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the core element." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I core element sequence-specific DNA binding" EXACT [] is_a: GO:0001046 ! core promoter sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: GO:0001165 name: RNA polymerase I upstream control element sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I." [GOC:txnOH, PMID:12865296 "Grummt 2003", PMID:14969726 "Comai 2004", PMID:8057832 "Reeder 1999"] synonym: "RNA polymerase I upstream element sequence-specific DNA binding" RELATED [] is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: GO:0001166 name: RNA polymerase I enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH, PMID:12865296 "Grummt 2003", PMID:14969726 "Comai 2004", PMID:8057832 "Reeder 1999"] is_a: GO:0001158 ! enhancer sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: GO:0001167 name: sequence-specific DNA binding RNA polymerase I transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001168 name: RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] is_a: GO:0001167 ! sequence-specific DNA binding RNA polymerase I transcription factor activity [Term] id: GO:0001169 name: RNA polymerase I core promoter sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] is_a: GO:0001167 ! sequence-specific DNA binding RNA polymerase I transcription factor activity [Term] id: GO:0001170 name: RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] is_a: GO:0001167 ! sequence-specific DNA binding RNA polymerase I transcription factor activity [Term] id: GO:0001171 name: reverse transcription namespace: biological_process def: "A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis." [GOC:txnOH, PMID:20358252] xref: Wikipedia:Reverse_transcription is_a: GO:0006278 ! RNA-dependent DNA replication [Term] id: GO:0001172 name: transcription, RNA-dependent namespace: biological_process def: "The cellular synthesis of RNA on a template of RNA." [GOC:txnOH] subset: gosubset_prok is_a: GO:0032774 ! RNA biosynthetic process [Term] id: GO:0001300 name: chronological cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934] synonym: "chronological cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001301 name: progressive alteration of chromatin involved in cell aging namespace: biological_process def: "The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, PMID:12044938] synonym: "age-dependent accumulation of genetic damage" RELATED [] synonym: "progressive alteration of chromatin during cell ageing" EXACT [] synonym: "progressive alteration of chromatin during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0016568 ! chromatin modification relationship: part_of GO:0007569 ! cell aging [Term] id: GO:0001302 name: replicative cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934] synonym: "replicative cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001303 name: nucleolar fragmentation involved in replicative aging namespace: biological_process def: "A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807] synonym: "nucleolar fragmentation during replicative ageing" RELATED [] synonym: "nucleolar fragmentation during replicative aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007576 ! nucleolar fragmentation relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001304 name: progressive alteration of chromatin involved in replicative cell aging namespace: biological_process def: "A process that results in changes in chromatin structure contributing to replicative cell aging." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT [] synonym: "progressive alteration of chromatin during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001305 name: progressive alteration of chromatin involved in chronological cell aging namespace: biological_process def: "A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during chronological cell ageing" RELATED [] synonym: "progressive alteration of chromatin during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001306 name: age-dependent response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] is_a: GO:0006979 ! response to oxidative stress relationship: part_of GO:0007571 ! age-dependent general metabolic decline [Term] id: GO:0001307 name: extrachromosomal circular DNA accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh] synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal circular DNA accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0007580 ! extrachromosomal circular DNA accumulation involved in cell aging [Term] id: GO:0001308 name: loss of chromatin silencing involved in replicative cell aging namespace: biological_process def: "The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934] synonym: "loss of chromatin silencing during replicative cell ageing" RELATED [] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0006345 ! loss of chromatin silencing [Term] id: GO:0001309 name: age-dependent telomere shortening namespace: biological_process def: "Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0010834 ! telomere maintenance via telomere shortening [Term] id: GO:0001310 name: extrachromosomal rDNA circle accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [] is_a: GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001311 name: formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" RELATED [] is_a: GO:0001313 ! formation of extrachromosomal circular DNA involved in replicative cell aging relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001312 name: replication of extrachromosomal rDNA circles involved in replicative cell aging namespace: biological_process def: "Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" RELATED [] synonym: "replication of extrachromosomal rDNA circles during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" RELATED [] is_a: GO:0001314 ! replication of extrachromosomal circular DNA involved in replicative cell aging relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001313 name: formation of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh] synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001325 ! formation of extrachromosomal circular DNA relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001314 name: replication of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT [] synonym: "replication of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001326 ! replication of extrachromosomal circular DNA relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001315 name: age-dependent response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] subset: gosubset_prok synonym: "age-dependent response to active oxygen species" EXACT [] synonym: "age-dependent response to AOS" EXACT [] synonym: "age-dependent response to reactive oxidative species" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate" EXACT [] synonym: "age-dependent response to ROI" EXACT [] synonym: "age-dependent response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0001306 ! age-dependent response to oxidative stress [Term] id: GO:0001316 name: age-dependent response to reactive oxygen species involved in replicative cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to active oxygen species during replicative cell aging" RELATED [] synonym: "age-dependent response to AOS during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT [] synonym: "age-dependent response to reactive oxygen species during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during replicative cell aging" RELATED [] synonym: "age-dependent response to ROS during replicative cell aging" RELATED [] is_a: GO:0001322 ! age-dependent response to oxidative stress involved in replicative cell aging is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species [Term] id: GO:0001317 name: accumulation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "accumulation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001316 ! age-dependent response to reactive oxygen species involved in replicative cell aging [Term] id: GO:0001318 name: formation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] synonym: "formation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "formation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0006464 ! protein modification process relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001319 name: inheritance of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh] synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "inheritance of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0008105 ! asymmetric protein localization relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001320 name: age-dependent response to reactive oxygen species involved in chronological cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to active oxygen species during chronological cell aging" RELATED [] synonym: "age-dependent response to AOS during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxidative species during chronological cell aging" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during chronological cell aging" RELATED [] synonym: "age-dependent response to ROS during chronological cell aging" RELATED [] is_a: GO:0001324 ! age-dependent response to oxidative stress involved in chronological cell aging is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species [Term] id: GO:0001321 name: age-dependent general metabolic decline involved in replicative cell aging namespace: biological_process def: "A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] synonym: "age-dependent general metabolic decline during replicative cell ageing" RELATED [] synonym: "age-dependent general metabolic decline involved in replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001322 name: age-dependent response to oxidative stress involved in replicative cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during replicative cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress is_a: GO:0034599 ! cellular response to oxidative stress relationship: part_of GO:0001321 ! age-dependent general metabolic decline involved in replicative cell aging [Term] id: GO:0001323 name: age-dependent general metabolic decline involved in chronological cell aging namespace: biological_process def: "A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] synonym: "age-dependent general metabolic decline during chronological cell ageing" RELATED [] synonym: "age-dependent general metabolic decline during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001324 name: age-dependent response to oxidative stress involved in chronological cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during chronological cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress is_a: GO:0034599 ! cellular response to oxidative stress relationship: part_of GO:0001323 ! age-dependent general metabolic decline involved in chronological cell aging [Term] id: GO:0001325 name: formation of extrachromosomal circular DNA namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0001326 name: replication of extrachromosomal circular DNA namespace: biological_process def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] subset: gosubset_prok is_a: GO:0006260 ! DNA replication [Term] id: GO:0001400 name: mating projection base namespace: cellular_component def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc] synonym: "base of shmoo tip" NARROW [] synonym: "conjugation tube base" NARROW [] is_a: GO:0044463 ! cell projection part relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0001401 name: mitochondrial sorting and assembly machinery complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361] comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'. synonym: "SAM complex" EXACT [] synonym: "TOB complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0001402 name: signal transduction involved in filamentous growth namespace: biological_process def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395] synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED [] synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0030447 ! filamentous growth [Term] id: GO:0001403 name: invasive growth in response to glucose limitation namespace: biological_process def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395] comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'invasive growth', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO. synonym: "colony morphology" RELATED [] is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0001404 name: invasive growth namespace: biological_process def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395] comment: This term was made obsolete because more appropriate terms were created. synonym: "tissue invasion" EXACT [] is_obsolete: true consider: GO:0044409 [Term] id: GO:0001405 name: presequence translocase-associated import motor namespace: cellular_component def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix." [GOC:mcc, PMID:14517234, PMID:14638855] synonym: "mitochondrial import motor" EXACT [] synonym: "PAM complex" EXACT [] synonym: "pre-sequence translocase-associated import motor" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005744 ! mitochondrial inner membrane presequence translocase complex [Term] id: GO:0001406 name: glycerophosphodiester transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity [Term] id: GO:0001407 name: glycerophosphodiester transport namespace: biological_process def: "The directed movement of glycerophosphodiesters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0015748 ! organophosphate ester transport [Term] id: GO:0001408 name: guanine nucleotide transport namespace: biological_process def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mcc] is_a: GO:0015865 ! purine nucleotide transport [Term] id: GO:0001409 name: guanine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other." [GOC:mcc] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity [Term] id: GO:0001410 name: chlamydospore formation namespace: biological_process alt_id: GO:0055027 def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094] synonym: "chlamydospore development" EXACT [] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development [Term] id: GO:0001411 name: hyphal tip namespace: cellular_component def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc] subset: goslim_candida is_a: GO:0030427 ! site of polarized growth [Term] id: GO:0001501 name: skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb, http://www.stedmans.com/] synonym: "skeletal development" EXACT [] is_a: GO:0048731 ! system development [Term] id: GO:0001502 name: cartilage condensation namespace: biological_process def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0001503 name: ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] synonym: "bone biosynthesis" EXACT [] synonym: "bone formation" EXACT [] synonym: "osteogenesis" EXACT [] xref: Wikipedia:Ossification is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001504 name: neurotransmitter uptake namespace: biological_process def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft." [ISBN:0123668387] synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "neurotransmitter import into glial cell" NARROW [] synonym: "neurotransmitter import into neuron" NARROW [] synonym: "neurotransmitter recycling" BROAD [] synonym: "neurotransmitter reuptake" EXACT [] xref: Reactome:112313 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1252935 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1279869 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1298783 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1326438 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1352554 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1372781 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1392791 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1417268 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1450357 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1470896 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1482927 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1497006 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1514393 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1526685 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1532414 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:1538070 "Neurotransmitter uptake and Metabolism In Glial Cells" is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport [Term] id: GO:0001505 name: regulation of neurotransmitter levels namespace: biological_process def: "Any process that modulates levels of neurotransmitter." [GOC:jl] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0007268 ! synaptic transmission [Term] id: GO:0001506 name: neurotransmitter biosynthetic process and storage namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387] comment: This term was made obsolete because it is an amalgamation of its two children. synonym: "neurotransmitter anabolism and storage" EXACT [] synonym: "neurotransmitter formation and storage" EXACT [] synonym: "neurotransmitter synthesis and storage" EXACT [] is_obsolete: true consider: GO:0042136 consider: GO:0042137 [Term] id: GO:0001507 name: acetylcholine catabolic process in synaptic cleft namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] synonym: "acetylcholine degradation in synaptic cleft" EXACT [] is_a: GO:0006581 ! acetylcholine catabolic process relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0001508 name: regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0001509 name: legumain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34] comment: This term was made obsolete because it represents a gene product. synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "citvac" RELATED [EC:3.4.22.34] synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34] synonym: "phaseolin activity" RELATED [EC:3.4.22.34] synonym: "proteinase B" RELATED [EC:3.4.22.34] synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34] synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34] xref: EC:3.4.22.34 xref: MetaCyc:3.4.22.34-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0001510 name: RNA methylation namespace: biological_process def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd] subset: gosubset_prok is_a: GO:0009451 ! RNA modification is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0001511 name: fibrillin namespace: molecular_function def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0001527 consider: GO:0005509 [Term] id: GO:0001512 name: dihydronicotinamide riboside quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2] synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2] synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2] synonym: "NQO(2) activity" EXACT [EC:1.10.99.2] synonym: "NQO2" RELATED [EC:1.10.99.2] synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2] synonym: "QR2 activity" RELATED [EC:1.10.99.2] synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2] synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [] xref: EC:1.10.99.2 xref: MetaCyc:1.10.99.2-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0001514 name: selenocysteine incorporation namespace: biological_process def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022] subset: gosubset_prok xref: RESID:AA0022 is_a: GO:0006451 ! translational readthrough [Term] id: GO:0001515 name: opioid peptide activity namespace: molecular_function def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005102 ! receptor binding [Term] id: GO:0001516 name: prostaglandin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai] subset: gosubset_prok synonym: "prostaglandin anabolism" EXACT [] synonym: "prostaglandin biosynthesis" EXACT [] synonym: "prostaglandin formation" EXACT [] synonym: "prostaglandin synthesis" EXACT [] is_a: GO:0006693 ! prostaglandin metabolic process is_a: GO:0046457 ! prostanoid biosynthetic process [Term] id: GO:0001517 name: N-acetylglucosamine 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001518 name: voltage-gated sodium channel complex namespace: cellular_component def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "voltage gated sodium channel complex" EXACT [] synonym: "voltage-dependent sodium channel complex" EXACT [] synonym: "voltage-sensitive sodium channel complex" EXACT [] xref: NIF_Subcellular:sao785001660 is_a: GO:0034706 ! sodium channel complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0001519 name: peptide amidation namespace: biological_process def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916] subset: gosubset_prok is_a: GO:0031179 ! peptide modification [Term] id: GO:0001520 name: outer dense fiber namespace: cellular_component def: "Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile." [ISBN:0824072820] synonym: "outer dense fibre" EXACT [] is_a: GO:0044447 ! axoneme part [Term] id: GO:0001522 name: pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] subset: gosubset_prok synonym: "pseudouridylation" EXACT [] xref: Wikipedia:Pseudouridine xref: Wikipedia:Pseudouridylation is_a: GO:0009451 ! RNA modification [Term] id: GO:0001523 name: retinoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "retinoid metabolism" EXACT [] xref: Reactome:975634 "Vitamin A uptake in enterocytes" is_a: GO:0016101 ! diterpenoid metabolic process [Term] id: GO:0001524 name: globin namespace: molecular_function def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001526 name: proteoglycan sulfate transfer namespace: biological_process def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd] comment: This term was made obsolete because it represents a group of molecular functions. synonym: "proteoglycan sulphate transfer" EXACT [] is_obsolete: true consider: GO:0006029 consider: GO:0006790 consider: GO:0050698 [Term] id: GO:0001527 name: microfibril namespace: cellular_component def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [http://www.xrefer.com/entry/490235] synonym: "extended fibrils" EXACT [] synonym: "fibrillin" RELATED [] is_a: GO:0043205 ! fibril [Term] id: GO:0001528 name: elastin namespace: molecular_function def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001529 name: elastin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001530 name: lipopolysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463] synonym: "endotoxin binding" BROAD [] synonym: "LPS binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0001531 name: interleukin-21 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-21 receptor." [GOC:ai] synonym: "IL-21" NARROW [] synonym: "interleukin-21 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0001532 name: interleukin-21 receptor activity namespace: molecular_function def: "Combining with interleukin-21 to initiate a change in cell activity." [GOC:jl] synonym: "IL-21 receptor activity" EXACT [GOC:mah] synonym: "IL-21R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019977 ! interleukin-21 binding [Term] id: GO:0001533 name: cornified envelope namespace: cellular_component def: "An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells." [PMID:11112355] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0001534 name: radial spoke namespace: cellular_component def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971] subset: goslim_pir xref: Wikipedia:Radial_spoke is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0001535 name: radial spokehead namespace: cellular_component def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:hjd] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001536 name: radial spoke stalk namespace: cellular_component def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001537 name: N-acetylgalactosamine 4-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai] synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001539 name: ciliary or flagellar motility namespace: biological_process def: "Cell motility due to movement of cilia or flagella." [GOC:hjd] subset: gosubset_prok synonym: "ciliary/flagellar motility" EXACT [] is_a: GO:0048870 ! cell motility [Term] id: GO:0001540 name: beta-amyloid binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0001541 name: ovarian follicle development namespace: biological_process def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators] synonym: "follicular phase" RELATED [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0061039 ! ovum-producing ovary development [Term] id: GO:0001542 name: ovulation from ovarian follicle namespace: biological_process def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0030728 ! ovulation relationship: part_of GO:0061039 ! ovum-producing ovary development [Term] id: GO:0001543 name: ovarian follicle rupture namespace: biological_process def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001542 ! ovulation from ovarian follicle [Term] id: GO:0001544 name: initiation of primordial ovarian follicle growth namespace: biological_process def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001545 name: primary ovarian follicle growth namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001546 name: preantral ovarian follicle growth namespace: biological_process def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development relationship: part_of GO:0048162 ! multi-layer follicle stage [Term] id: GO:0001547 name: antral ovarian follicle growth namespace: biological_process def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [http://ovary.stanford.edu] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001548 name: follicular fluid formation in ovarian follicle antrum namespace: biological_process def: "The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis." [GOC:dph, GOC:tb, http://ovary.stanford.edu] synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT [] synonym: "ovarian follicle antrum/follicular fluid formation" EXACT [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001547 ! antral ovarian follicle growth [Term] id: GO:0001549 name: cumulus cell differentiation namespace: biological_process def: "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [http://ovary.stanford.edu] synonym: "ovarian cumulus cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001550 name: ovarian cumulus expansion namespace: biological_process def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [http://ovary.stanford.edu] synonym: "ovarian cumulus growth" RELATED [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001551 name: ovarian follicle endowment namespace: biological_process def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001552 name: ovarian follicle atresia namespace: biological_process def: "Ovarian follicle demise mediated by apoptosis." [http://ovary.stanford.edu] is_a: GO:0006915 ! apoptosis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0061039 ! ovum-producing ovary development [Term] id: GO:0001553 name: luteinization namespace: biological_process def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [http://ovary.stanford.edu] synonym: "luteal phase" RELATED [] xref: Wikipedia:Luteal_phase xref: Wikipedia:Luteinization is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0061039 ! ovum-producing ovary development [Term] id: GO:0001554 name: luteolysis namespace: biological_process def: "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy." [http://ovary.stanford.edu, PMID:10617764] xref: Wikipedia:Luteolysis is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0061039 ! ovum-producing ovary development [Term] id: GO:0001555 name: oocyte growth namespace: biological_process def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048588 ! developmental cell growth is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0001556 name: oocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu] xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0001557 name: metabolic process resulting in cell growth namespace: biological_process def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph] comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms. is_obsolete: true replaced_by: GO:0008152 replaced_by: GO:0016049 [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell growth." [GOC:go_curators] subset: gosubset_prok xref: Reactome:110498 "DTOR is positively regulated by DRheb-GTP" is_a: GO:0040008 ! regulation of growth is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0016049 ! cell growth [Term] id: GO:0001559 name: regulation of cell growth by detection of nuclear:cytoplasmic ratio namespace: biological_process def: "Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT [] synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0016475 ! detection of nuclear:cytoplasmic ratio [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] is_a: GO:0001558 ! regulation of cell growth relationship: part_of GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0001561 name: fatty acid alpha-oxidation namespace: biological_process def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [http://www.peroxisome.org/Scientist/Biochemistry/alpha-oxidation.html] subset: gosubset_prok xref: MetaCyc:PWY-2501 xref: Reactome:1253673 "Alpha-oxidation of phytanate" xref: Reactome:1280605 "Alpha-oxidation of phytanate" xref: Reactome:1299436 "Alpha-oxidation of phytanate" xref: Reactome:1327190 "Alpha-oxidation of phytanate" xref: Reactome:1353285 "Alpha-oxidation of phytanate" xref: Reactome:1373462 "Alpha-oxidation of phytanate" xref: Reactome:1393483 "Alpha-oxidation of phytanate" xref: Reactome:1417983 "Alpha-oxidation of phytanate" xref: Reactome:1451067 "Alpha-oxidation of phytanate" xref: Reactome:1471427 "Alpha-oxidation of phytanate" xref: Reactome:1483378 "Alpha-oxidation of phytanate" xref: Reactome:1497042 "Alpha-oxidation of phytanate" xref: Reactome:1514429 "Alpha-oxidation of phytanate" xref: Reactome:1521293 "Alpha-oxidation of phytanate" xref: Reactome:1526999 "Alpha-oxidation of phytanate" xref: Reactome:1532737 "Alpha-oxidation of phytanate" xref: Reactome:1538088 "Alpha-oxidation of phytanate" xref: Reactome:1539362 "Alpha-oxidation of phytanate" xref: Reactome:389599 "Alpha-oxidation of phytanate" is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0001562 name: response to protozoan namespace: biological_process alt_id: GO:0042833 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai] synonym: "resistance to pathogenic protozoa" RELATED [] synonym: "response to protozoa" EXACT [] synonym: "response to protozoon" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0001563 name: detection of protozoan namespace: biological_process def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai] synonym: "detection of protozoa" EXACT [] synonym: "detection of protozoon" EXACT [] synonym: "perception of protozoa" RELATED [] is_a: GO:0001562 ! response to protozoan is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0001564 name: resistance to pathogenic protozoa namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0001562 [Term] id: GO:0001565 name: phorbol ester receptor activity namespace: molecular_function def: "Combining with a phorbol ester to initiate a change in cell activity." [GOC:ai, PMID:10506570] is_a: GO:0004872 ! receptor activity [Term] id: GO:0001566 name: non-kinase phorbol ester receptor activity namespace: molecular_function def: "Phorbol ester/diacylglycerol binding proteins that do not have intrinsic kinase activity." [PMID:10506570] is_a: GO:0001565 ! phorbol ester receptor activity [Term] id: GO:0001567 name: cholesterol 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O." [EC:1.14.99.38, RHEA:21107] synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38] synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38] xref: EC:1.14.99.38 xref: KEGG:R07218 xref: MetaCyc:1.14.99.38-RXN xref: RHEA:21107 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001569 name: patterning of blood vessels namespace: biological_process def: "The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] synonym: "branching involved in blood vessel morphogenesis" EXACT [GOC:dph] is_a: GO:0007389 ! pattern specification process is_a: GO:0048754 ! branching morphogenesis of a tube is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0001525 ! angiogenesis [Term] id: GO:0001570 name: vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] synonym: "vascular morphogenesis" EXACT [] xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001571 name: non-tyrosine kinase fibroblast growth factor receptor activity namespace: molecular_function def: "A receptor belonging to the FGFR family but lacking the tyrosine kinase domain." [PMID:11418238] synonym: "non-tyrosine kinase FGF receptor activity" EXACT [] synonym: "non-tyrosine kinase FGFR activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0001572 name: lactosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0471586501] subset: gosubset_prok synonym: "lactosylceramide anabolism" EXACT [] synonym: "lactosylceramide biosynthesis" EXACT [] synonym: "lactosylceramide formation" EXACT [] synonym: "lactosylceramide synthesis" EXACT [] is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046476 ! glycosylceramide biosynthetic process is_a: GO:0046478 ! lactosylceramide metabolic process [Term] id: GO:0001573 name: ganglioside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ganglioside metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001574 name: ganglioside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ganglioside anabolism" EXACT [] synonym: "ganglioside biosynthesis" EXACT [] synonym: "ganglioside formation" EXACT [] synonym: "ganglioside synthesis" EXACT [] is_a: GO:0001573 ! ganglioside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process [Term] id: GO:0001575 name: globoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "globoside metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001576 name: globoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "globoside anabolism" EXACT [] synonym: "globoside biosynthesis" EXACT [] synonym: "globoside formation" EXACT [] synonym: "globoside synthesis" EXACT [] is_a: GO:0001575 ! globoside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process [Term] id: GO:0001577 name: galectin namespace: molecular_function def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891] comment: This term was made obsolete because it refers to a class of gene products. synonym: "S-type lectin" EXACT [] is_obsolete: true consider: GO:0007157 consider: GO:0016936 [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0001579 name: medium-chain fatty acid transport namespace: biological_process def: "The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Medium-chain fatty acids are fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0001580 name: detection of chemical stimulus involved in sensory perception of bitter taste namespace: biological_process def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "bitter taste detection" EXACT [] synonym: "perception of bitter taste, detection of chemical stimulus" EXACT [] synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of bitter taste" EXACT [] synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT [] synonym: "sensory transduction of bitter taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050913 ! sensory perception of bitter taste [Term] id: GO:0001581 name: detection of chemical stimulus involved in sensory perception of sour taste namespace: biological_process def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sour taste, detection of chemical stimulus" EXACT [] synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory detection of sour taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory transduction of sour taste" EXACT [] synonym: "sour taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050915 ! sensory perception of sour taste [Term] id: GO:0001582 name: detection of chemical stimulus involved in sensory perception of sweet taste namespace: biological_process def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sweet taste, detection of chemical stimulus" EXACT [] synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory detection of sweet taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory transduction of sweet taste" EXACT [] synonym: "sweet taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050916 ! sensory perception of sweet taste [Term] id: GO:0001583 name: detection of chemical stimulus involved in sensory perception of salty taste namespace: biological_process def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of salty taste, detection of chemical stimulus" EXACT [] synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT [] synonym: "salty taste detection" EXACT [] synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory detection of salty taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory transduction of salty taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050914 ! sensory perception of salty taste [Term] id: GO:0001584 name: rhodopsin-like receptor activity namespace: molecular_function alt_id: GO:0001620 def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505] comment: This term was made obsolete because it represents a gene product and is named based on protein features. subset: gosubset_prok synonym: "Class A G protein coupled receptor" EXACT [] synonym: "Class A G-protein coupled receptor" EXACT [] synonym: "Class A GPCR" EXACT [] synonym: "class A orphan receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001586 name: 5-HT1 receptor activity namespace: molecular_function def: "A serotonin receptor activity that acts via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, PMID:18571247] is_a: GO:0004993 ! serotonin receptor activity [Term] id: GO:0001587 name: 5-HT2 receptor activity namespace: molecular_function def: "A serotonin receptor activity that acts via coupling to G11/q to initiate a change in cell activity." [GOC:mah, PMID:18571247] is_a: GO:0004993 ! serotonin receptor activity [Term] id: GO:0001588 name: dopamine receptor activity, coupled via Gs namespace: molecular_function def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033] is_a: GO:0004952 ! dopamine receptor activity [Term] id: GO:0001589 name: dopamine D5 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D5 receptors." [IUPHAR_RECEPTOR:2260] is_a: GO:0001588 ! dopamine receptor activity, coupled via Gs [Term] id: GO:0001590 name: dopamine D1 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D1 receptors." [IUPHAR_RECEPTOR:2252] is_a: GO:0001588 ! dopamine receptor activity, coupled via Gs [Term] id: GO:0001591 name: dopamine receptor activity, coupled via Gi/Go namespace: molecular_function def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033] is_a: GO:0004952 ! dopamine receptor activity [Term] id: GO:0001592 name: dopamine D3 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D3 receptors." [IUPHAR_RECEPTOR:2256] is_a: GO:0001591 ! dopamine receptor activity, coupled via Gi/Go [Term] id: GO:0001593 name: dopamine D4 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D4 receptors." [IUPHAR_RECEPTOR:2258] is_a: GO:0001591 ! dopamine receptor activity, coupled via Gi/Go [Term] id: GO:0001594 name: trace-amine receptor activity namespace: molecular_function def: "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals." [GOC:mah, PMID:19325074] is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0001595 name: angiotensin receptor activity namespace: molecular_function def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001596 name: angiotensin type I receptor activity namespace: molecular_function def: "An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms." [GOC:mah, PMID:10977869] is_a: GO:0001595 ! angiotensin receptor activity [Term] id: GO:0001597 name: apelin-like receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because the function it represents does not exist. synonym: "APJ-like receptor" EXACT [] is_obsolete: true consider: GO:0031704 [Term] id: GO:0001598 name: chemokine receptor-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001599 name: endothelin-A receptor activity namespace: molecular_function def: "A G-protein coupled receptor that preferentially binds endothelin 1." [IUPHAR_RECEPTOR:2263, PMID:8582288] is_a: GO:0004962 ! endothelin receptor activity [Term] id: GO:0001600 name: endothelin-B receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds all endothelin molecules with approximately equal affinity." [IUPHAR_RECEPTOR:2265, PMID:8582288] is_a: GO:0004962 ! endothelin receptor activity [Term] id: GO:0001601 name: peptide YY receptor activity namespace: molecular_function def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001602 name: pancreatic polypeptide receptor activity namespace: molecular_function def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001603 name: vasopressin-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators] is_obsolete: true [Term] id: GO:0001604 name: urotensin II receptor activity namespace: molecular_function def: "Combining with urotensin II to initiate a change in cell activity." [GOC:mah, PMID:15102493] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001605 name: adrenomedullin receptor activity namespace: molecular_function def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai] synonym: "G10D receptor" NARROW [] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001606 name: GPR37/endothelin B-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001607 name: neuromedin U receptor activity namespace: molecular_function def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai] synonym: "NMUR activity" EXACT [] is_a: GO:0008188 ! neuropeptide receptor activity is_a: GO:0042924 ! neuromedin U binding [Term] id: GO:0001608 name: nucleotide receptor activity, G-protein coupled namespace: molecular_function def: "A GPCR that binds a nucleotide or nucleotide derivative as its ligand." [GOC:dph, IUPHAR_GPCR:1294] synonym: "G protein coupled nucleotide receptor activity" EXACT [] synonym: "G-protein-coupled nucleotide receptor activity" EXACT [] synonym: "nucleotide receptor activity, G protein coupled" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001609 name: adenosine receptor activity, G-protein coupled namespace: molecular_function alt_id: GO:0001610 alt_id: GO:0001611 alt_id: GO:0001612 alt_id: GO:0001613 alt_id: GO:0008501 def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:mah, PMID:9755289] synonym: "A1 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "adenosine nucleotide receptor" BROAD [] synonym: "adenosine receptor activity, G protein coupled" EXACT [] synonym: "G protein coupled A1 adenosine receptor activity" NARROW [] synonym: "G protein coupled A2A adenosine receptor activity" NARROW [] synonym: "G protein coupled A2B adenosine receptor activity" NARROW [] synonym: "G protein coupled A3 adenosine receptor activity" NARROW [] synonym: "G protein coupled adenosine receptor activity" EXACT [] synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled adenosine receptor activity" EXACT [] synonym: "P1 receptor" EXACT [PMID:9755289] xref: Reactome:71 "adenosine receptor activity, G-protein coupled" is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0035586 ! purinergic receptor activity [Term] id: GO:0001614 name: purinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a purine nucleotide to initiate a change in cell activity." [GOC:mah] synonym: "P2 receptor" RELATED [PMID:9755289] is_a: GO:0016502 ! nucleotide receptor activity is_a: GO:0035586 ! purinergic receptor activity [Term] id: GO:0001615 name: thyrotropin releasing hormone and secretagogue-like receptors activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001616 name: growth hormone secretagogue receptor activity namespace: molecular_function def: "Combining with ghrelin to initiate a change in cell activity." [GOC:mah, PMID:17983853] synonym: "ghrelin receptor activity" EXACT [GOC:mah, PMID:17983853] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001617 name: growth hormone secretagogue-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001618 name: viral receptor activity namespace: molecular_function def: "Combining with a virus component to initiate a change in cell activity." [GOC:dph] is_a: GO:0004872 ! receptor activity [Term] id: GO:0001619 name: lysosphingolipid and lysophosphatidic acid receptor activity namespace: molecular_function def: "Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph] is_a: GO:0045125 ! bioactive lipid receptor activity [Term] id: GO:0001621 name: ADP receptor activity namespace: molecular_function def: "Combining with ADP to initiate a change in cell activity. ADP receptors are present at the surface of platelets, where they are involved in platelet aggregation." [GOC:mah, PMID:11196645] synonym: "K101 receptor" NARROW [] synonym: "platelet ADP receptor activity" NARROW [GOC:mah] is_a: GO:0045028 ! purinergic nucleotide receptor activity, G-protein coupled [Term] id: GO:0001626 name: nociceptin/orphanin-FQ receptor activity namespace: molecular_function def: "Combining with the peptide nociceptin/orphanin-FQ to initiate a change in cell activity." [GOC:mah, PMID:18670432] synonym: "ORPH receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001627 name: leucine-rich G-protein receptor-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "leucine-rich G protein receptor-like receptor activity" EXACT [] synonym: "LGR-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001628 name: gastropyloric receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the gastropyloric receptor is a type of neuron. synonym: "GPR receptor" EXACT [] is_obsolete: true [Term] id: GO:0001629 name: G-protein receptor 45-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "G protein receptor 45-like receptor activity" EXACT [] synonym: "GPR45-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001630 name: GP40-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001631 name: cysteinyl leukotriene receptor activity namespace: molecular_function def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "CysLT receptor" EXACT [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001632 name: leukotriene B4 receptor activity namespace: molecular_function def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "BLT receptor" NARROW [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001633 name: secretin-like receptor activity namespace: molecular_function alt_id: GO:0001638 def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah, IUPHAR_GPCR:1506] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "class B G protein coupled receptor" EXACT [] synonym: "class B G-protein coupled receptor" EXACT [] synonym: "class B GPCR" EXACT [] synonym: "class B orphan receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001634 name: pituitary adenylate cyclase-activating polypeptide receptor activity namespace: molecular_function alt_id: GO:0016522 def: "A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb] synonym: "PACAP receptor" EXACT [] synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT [] synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb] synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED [] synonym: "pituitary adenylate cyclase-activating polypeptide receptor activity" RELATED [] synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT [] xref: Reactome:272 "pituitary adenylate cyclase-activating polypeptide receptor activity" is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001635 name: calcitonin gene-related polypeptide receptor activity namespace: molecular_function def: "Combining with a calcitonin gene-related polypeptide to initiate a change in cell activity." [GOC:mah, PMID:12037140] synonym: "CGRP receptor" EXACT [] xref: Wikipedia:CALCRL is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001636 name: corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001637 name: G-protein chemoattractant receptor activity namespace: molecular_function def: "Combining with a chemoattractant peptide to initiate a G-protein mediated change in cell activity." [GOC:mah] synonym: "G protein chemoattractant receptor activity" EXACT [] synonym: "G-protein coupled chemoattractant receptor activity" EXACT [GOC:mah] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001639 name: PLC activating metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303] synonym: "Group I metabotropic glutamate receptor" RELATED [] synonym: "group I metabotropic glutamate receptor activity" RELATED [] synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT [] is_a: GO:0008066 ! glutamate receptor activity [Term] id: GO:0001640 name: adenylate cyclase inhibiting metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity." [GOC:dph] synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0008066 ! glutamate receptor activity [Term] id: GO:0001641 name: group II metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph] is_a: GO:0001640 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity [Term] id: GO:0001642 name: group III metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303] is_a: GO:0001640 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity [Term] id: GO:0001646 name: cAMP receptor activity namespace: molecular_function alt_id: GO:0001644 def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) to initiate a change in cell activity." [GOC:pg] synonym: "3',5' cAMP receptor activity" EXACT [] synonym: "3',5'-cAMP receptor activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT [] synonym: "class E G protein coupled receptor" BROAD [] synonym: "class E G-protein coupled receptor" BROAD [] synonym: "class E GPCR" BROAD [] synonym: "cyclic AMP receptor activity" EXACT [] is_a: GO:0001614 ! purinergic nucleotide receptor activity is_a: GO:0030552 ! cAMP binding [Term] id: GO:0001647 name: G-protein coupled cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin to initiate a change in cell activity. The receptor is G-protein coupled." [GOC:dph] synonym: "G protein coupled cytokinin receptor activity" EXACT [] synonym: "G-protein-coupled cytokinin receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0009884 ! cytokinin receptor activity [Term] id: GO:0001648 name: proteinase activated receptor activity namespace: molecular_function def: "A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor." [GOC:mah, PMID:11356985] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001649 name: osteoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone." [CL:0000062, GOC:jid] synonym: "osteoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001503 ! ossification [Term] id: GO:0001650 name: fibrillar center namespace: cellular_component def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561] synonym: "fibrillar centre" EXACT [] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001651 name: dense fibrillar component namespace: cellular_component def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001652 name: granular component namespace: cellular_component def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001653 name: peptide receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] synonym: "endogenous peptide receptor activity" NARROW [] synonym: "exogenous peptide receptor activity" NARROW [] is_a: GO:0004872 ! receptor activity is_a: GO:0042277 ! peptide binding [Term] id: GO:0001654 name: eye development namespace: biological_process alt_id: GO:0042460 def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development [Term] id: GO:0001655 name: urogenital system development namespace: biological_process def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048731 ! system development [Term] id: GO:0001656 name: metanephros development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752] is_a: GO:0001822 ! kidney development [Term] id: GO:0001657 name: ureteric bud development namespace: biological_process def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0035295 ! tube development [Term] id: GO:0001658 name: branching involved in ureteric bud morphogenesis namespace: biological_process def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378] synonym: "ureteric bud branching" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of a tube is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0060675 ! ureteric bud morphogenesis [Term] id: GO:0001659 name: temperature homeostasis namespace: biological_process def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001660 name: fever generation namespace: biological_process def: "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection." [GOC:dph, GOC:jl] synonym: "pyrexia" BROAD [] xref: Wikipedia:Fever is_a: GO:0006953 ! acute-phase response is_a: GO:0031649 ! heat generation [Term] id: GO:0001661 name: conditioned taste aversion namespace: biological_process def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] xref: Wikipedia:Conditioned_taste_aversion xref: Wikipedia:Taste_aversion is_a: GO:0007631 ! feeding behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0001662 name: behavioral fear response namespace: biological_process def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659] synonym: "behavioural fear response" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0042596 ! fear response [Term] id: GO:0001664 name: G-protein-coupled receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein-coupled receptor." [GOC:ceb, GOC:dph] synonym: "G protein coupled receptor binding" EXACT [] synonym: "G protein coupled receptor ligand" NARROW [] synonym: "G-protein-coupled receptor ligand" NARROW [] xref: Reactome:260 "G-protein-coupled receptor binding" is_a: GO:0005102 ! receptor binding [Term] id: GO:0001665 name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3] synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3] synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3] xref: EC:2.4.99.3 xref: MetaCyc:2.4.99.3-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to lowered oxygen tension" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0001667 name: ameboidal cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration [Term] id: GO:0001669 name: acrosomal vesicle namespace: cellular_component def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "acrosome" RELATED [GOC:dph] xref: Wikipedia:Acrosome is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0001670 name: dopamine D2 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D2 receptors." [IUPHAR_RECEPTOR:2254] is_a: GO:0001591 ! dopamine receptor activity, coupled via Gi/Go [Term] id: GO:0001671 name: ATPase activator activity namespace: molecular_function def: "Functions to increase the rate of ATP hydrolysis." [GOC:ajp] synonym: "ATPase stimulator activity" EXACT [] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0060590 ! ATPase regulator activity [Term] id: GO:0001672 name: regulation of chromatin assembly or disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] synonym: "regulation of chromatin assembly/disassembly" EXACT [] is_a: GO:0033044 ! regulation of chromosome organization relationship: regulates GO:0006333 ! chromatin assembly or disassembly [Term] id: GO:0001673 name: male germ cell nucleus namespace: cellular_component alt_id: GO:0043081 def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu] synonym: "male germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001674 name: female germ cell nucleus namespace: cellular_component alt_id: GO:0043080 def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] synonym: "female germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001675 name: acrosome assembly namespace: biological_process def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb] synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0001676 name: long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:ajp] subset: gosubset_prok synonym: "long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] subset: gosubset_prok synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001678 name: cellular glucose homeostasis namespace: biological_process def: "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0042593 ! glucose homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0001680 name: tRNA 3'-terminal CCA addition namespace: biological_process def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript." [GOC:go_curators] subset: gosubset_prok is_a: GO:0042780 ! tRNA 3'-end processing [Term] id: GO:0001681 name: sialate O-acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039] subset: gosubset_prok synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53] synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53] synonym: "sialate 9(4)-O-acetylesterase activity" EXACT [] xref: EC:3.1.1.53 xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN is_a: GO:0008126 ! acetylesterase activity [Term] id: GO:0001682 name: tRNA 5'-leader removal namespace: biological_process def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] subset: gosubset_prok synonym: "tRNA 5' leader removal" EXACT [] is_a: GO:0008033 ! tRNA processing [Term] id: GO:0001683 name: axonemal dynein heavy chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001684 name: axonemal dynein intermediate chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001685 name: axonemal dynein intermediate light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001686 name: axonemal dynein light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001687 name: cytoplasmic dynein heavy chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001688 name: cytoplasmic dynein intermediate chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001689 name: cytoplasmic dynein intermediate light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001690 name: cytoplasmic dynein light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001691 name: pseudophosphatase activity namespace: molecular_function def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp] is_a: GO:0019212 ! phosphatase inhibitor activity [Term] id: GO:0001692 name: histamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0001694 name: histamine biosynthetic process namespace: biological_process alt_id: GO:0001693 def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine anabolism" EXACT [] synonym: "histamine biosynthesis" EXACT [] synonym: "histamine formation" EXACT [] synonym: "histamine synthesis" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0001695 name: histamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine breakdown" EXACT [] synonym: "histamine catabolism" EXACT [] synonym: "histamine degradation" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0001696 name: gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] synonym: "hydrochloric acid secretion" NARROW [] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion [Term] id: GO:0001697 name: histamine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001698 name: gastrin-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001699 name: acetylcholine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0001701 name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development [Term] id: GO:0001702 name: gastrulation with mouth forming second namespace: biological_process alt_id: GO:0010003 alt_id: GO:0048276 def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "deuterostomic gastrulation" EXACT [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001703 name: gastrulation with mouth forming first namespace: biological_process def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "protostomic gastrulation" NARROW [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007492 ! endoderm development [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0048332 ! mesoderm morphogenesis [Term] id: GO:0001708 name: cell fate specification namespace: biological_process def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001709 name: cell fate determination namespace: biological_process def: "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] xref: Wikipedia:Cell_fate_determination is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001710 name: mesodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437] synonym: "mesoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layers relationship: part_of GO:0048333 ! mesodermal cell differentiation [Term] id: GO:0001711 name: endodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437] synonym: "endoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layers relationship: part_of GO:0001706 ! endoderm formation [Term] id: GO:0001712 name: ectodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layers relationship: part_of GO:0001705 ! ectoderm formation relationship: part_of GO:0010668 ! ectodermal cell differentiation [Term] id: GO:0001713 name: ectodermal cell fate determination namespace: biological_process def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001714 name: endodermal cell fate specification namespace: biological_process def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "endoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001711 ! endodermal cell fate commitment [Term] id: GO:0001715 name: ectodermal cell fate specification namespace: biological_process def: "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "ectoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001716 name: L-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.2] subset: gosubset_prok synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2] synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2] xref: EC:1.4.3.2 xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0001717 name: conversion of seryl-tRNAsec to selenocys-tRNAsec namespace: biological_process def: "The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine." [ISBN:155581073X] subset: gosubset_prok is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001720 name: conversion of lysyl-tRNA to pyrrolysyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639] subset: gosubset_prok is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001721 name: intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "IFAP" EXACT [] is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001722 name: type I intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001723 name: type II intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001724 name: type III intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0045098 [Term] id: GO:0001725 name: stress fiber namespace: cellular_component def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] synonym: "actin cable" RELATED [GOC:mah] synonym: "stress fibre" EXACT [] is_a: GO:0032432 ! actin filament bundle is_a: GO:0042641 ! actomyosin [Term] id: GO:0001726 name: ruffle namespace: cellular_component def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] synonym: "membrane ruffle" RELATED [] is_a: GO:0042995 ! cell projection relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0001727 name: lipid kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd] subset: gosubset_prok is_a: GO:0016301 ! kinase activity [Term] id: GO:0001729 name: ceramide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138] synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138] synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138] xref: EC:2.7.1.138 xref: MetaCyc:CERAMIDE-KINASE-RXN is_a: GO:0001727 ! lipid kinase activity [Term] id: GO:0001730 name: 2'-5'-oligoadenylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "(2-5')oligo(A) synthetase activity" EXACT [] synonym: "2'-5' oligoadenylate synthetase activity" EXACT [] synonym: "2-5A synthetase activity" EXACT [] synonym: "oligo-2',5'-adenylate synthetase activity" EXACT [] xref: MetaCyc:RXN-10798 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0001731 name: formation of translation preinitiation complex namespace: biological_process def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children. subset: gosubset_prok synonym: "formation of translation pre-initiation complex" EXACT [] synonym: "translation preinitiation complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001732 name: formation of translation initiation complex namespace: biological_process def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd] subset: gosubset_prok synonym: "translation initiation complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001733 name: galactosylceramide sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929] synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "cerebroside sulfotransferase activity" EXACT [] synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactosylceramide sulphotransferase activity" EXACT [] synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "GSase" EXACT [EC:2.8.2.11] xref: EC:2.8.2.11 xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity [Term] id: GO:0001734 name: mRNA (N6-adenosine)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U." [GOC:hjd] xref: Reactome:2399 "mRNA (N6-adenosine)-methyltransferase activity" is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0001735 name: prenylcysteine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd] synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5] synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5] xref: EC:1.8.3.5 xref: MetaCyc:1.8.3.5-RXN is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0001736 name: establishment of planar polarity namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] synonym: "establishment of planar cell polarity" NARROW [] is_a: GO:0007164 ! establishment of tissue polarity relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium [Term] id: GO:0001737 name: establishment of imaginal disc-derived wing hair orientation namespace: biological_process def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] synonym: "establishment of wing hair orientation" EXACT [] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0001738 name: morphogenesis of a polarized epithelium namespace: biological_process def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] synonym: "epithelial polarization" EXACT [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0001739 name: sex chromatin namespace: cellular_component def: "A condensed mass of compacted chromatin that represents an inactivated X chromosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005720 ! nuclear heterochromatin relationship: part_of GO:0000803 ! sex chromosome [Term] id: GO:0001740 name: Barr body namespace: cellular_component def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] xref: Wikipedia:Barr_body is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000805 ! X chromosome is_a: GO:0001739 ! sex chromatin [Term] id: GO:0001741 name: XY body namespace: cellular_component def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] is_a: GO:0001739 ! sex chromatin [Term] id: GO:0001742 name: oenocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators] synonym: "oenocyte cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0001743 name: optic placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0048598 ! embryonic morphogenesis [Term] id: GO:0001744 name: optic lobe placode formation namespace: biological_process alt_id: GO:0007457 def: "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor formation" EXACT [] is_a: GO:0001743 ! optic placode formation relationship: part_of GO:0001748 ! optic lobe placode development [Term] id: GO:0001745 name: compound eye morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0048749 ! compound eye development [Term] id: GO:0001746 name: Bolwig's organ morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0055034 ! Bolwig's organ development [Term] id: GO:0001748 name: optic lobe placode development namespace: biological_process alt_id: GO:0048049 def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor development" EXACT [] synonym: "optic placode development" BROAD [] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0001750 name: photoreceptor outer segment namespace: cellular_component def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [ISBN:0824072820] is_a: GO:0031513 ! nonmotile primary cilium [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0001752 name: compound eye photoreceptor fate commitment namespace: biological_process alt_id: GO:0007459 def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0042706 ! eye photoreceptor cell fate commitment relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0001753 name: adult eye photoreceptor development (sensu Drosophila) namespace: biological_process def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators] comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins. is_obsolete: true consider: GO:0042051 [Term] id: GO:0001754 name: eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation relationship: part_of GO:0048592 ! eye morphogenesis [Term] id: GO:0001755 name: neural crest cell migration namespace: biological_process def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] is_a: GO:0001667 ! ameboidal cell migration relationship: part_of GO:0014032 ! neural crest cell development [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern formation is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0043009 ! chordate embryonic development relationship: part_of GO:0061053 ! somite development [Term] id: GO:0001757 name: somite specification namespace: biological_process def: "The process in which individual somites establish identity during embryogenesis." [GOC:dph] is_a: GO:0007379 ! segment specification is_a: GO:0009880 ! embryonic pattern specification relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0001758 name: retinal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36] synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36] synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36] xref: EC:1.2.1.36 xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0001759 name: organ induction namespace: biological_process def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437] synonym: "induction of an organ" EXACT [GOC:curators] is_a: GO:0003156 ! regulation of organ formation is_a: GO:0031128 ! developmental induction is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0010092 ! specification of organ identity [Term] id: GO:0001760 name: aminocarboxymuconate-semialdehyde decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2)." [EC:4.1.1.45, RHEA:16560] subset: gosubset_prok synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45] xref: EC:4.1.1.45 xref: KEGG:R04323 xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN xref: RHEA:16560 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0001761 name: beta-alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd] synonym: "beta-alanine transporter activity" BROAD [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0001762 name: beta-alanine transport namespace: biological_process def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0001763 name: morphogenesis of a branching structure namespace: biological_process def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "branching morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001764 name: neuron migration namespace: biological_process def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [GOC:go_curators] synonym: "neuron chemotaxis" EXACT [GOC:curators] synonym: "neuron guidance" RELATED [GOC:curators] synonym: "neuronal migration" EXACT [] xref: Wikipedia:Neural_development#Neuron_migration xref: Wikipedia:Neuron_migration is_a: GO:0016477 ! cell migration relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0001765 name: membrane raft assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198] synonym: "lipid raft assembly" EXACT [GOC:mah] synonym: "lipid raft formation" RELATED [] synonym: "membrane raft formation" RELATED [GOC:mah] is_a: GO:0031579 ! membrane raft organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0001766 name: membrane raft polarization namespace: biological_process def: "The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [PMID:12615889] synonym: "lipid raft polarization" EXACT [] is_a: GO:0031580 ! membrane raft distribution [Term] id: GO:0001767 name: establishment of lymphocyte polarity namespace: biological_process def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "lymphocyte polarization" EXACT [] is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001768 name: establishment of T cell polarity namespace: biological_process def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "establishment of T lymphocyte polarity" EXACT [] synonym: "establishment of T-cell polarity" EXACT [] synonym: "establishment of T-lymphocyte polarity" EXACT [] synonym: "T cell polarization" EXACT [] synonym: "T lymphocyte polarization" EXACT [] synonym: "T-cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042110 ! T cell activation [Term] id: GO:0001769 name: establishment of B cell polarity namespace: biological_process def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889] comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells. synonym: "B cell polarization" EXACT [] synonym: "B lymphocyte polarization" EXACT [] synonym: "B-cell polarization" EXACT [] synonym: "establishment of B lymphocyte polarity" EXACT [] synonym: "establishment of B-cell polarity" EXACT [] synonym: "establishment of B-lymphocyte polarity" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042113 ! B cell activation [Term] id: GO:0001770 name: establishment of natural killer cell polarity namespace: biological_process def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849] synonym: "establishment of NK cell polarity" EXACT [] synonym: "natural killer cell polarization" EXACT [] synonym: "NK cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0030101 ! natural killer cell activation [Term] id: GO:0001771 name: immunological synapse formation namespace: biological_process def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330] synonym: "formation of immunological synapse" EXACT [GOC:curators] is_a: GO:0009988 ! cell-cell recognition relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001772 name: immunological synapse namespace: cellular_component def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300] synonym: "c-SMAC" NARROW [PMID:14724296] synonym: "supramolecular activation cluster" EXACT [PMID:14724296] xref: Wikipedia:Immunological_synapse is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0001773 name: myeloid dendritic cell activation namespace: biological_process def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0001774 name: microglial cell activation namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] is_a: GO:0042116 ! macrophage activation [Term] id: GO:0001775 name: cell activation namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0001776 name: leukocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. synonym: "immune cell homeostasis" EXACT [] synonym: "leucocyte homeostasis" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0001777 name: T cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] synonym: "resting T cell proliferation" EXACT [] synonym: "resting T-cell proliferation" EXACT [] synonym: "T lymphocyte homeostatic proliferation" EXACT [] synonym: "T-cell homeostatic proliferation" EXACT [] synonym: "T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0001778 name: plasma membrane repair namespace: biological_process def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704] is_a: GO:0007009 ! plasma membrane organization relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0001779 name: natural killer cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development" RELATED [GOC:add] synonym: "NK cell differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0030101 ! natural killer cell activation [Term] id: GO:0001780 name: neutrophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:12752675, PMID:12960266] comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0001781 name: neutrophil apoptosis namespace: biological_process def: "The process of apoptosis in neutrophils." [GOC:add, PMID:12752675, PMID:12960266] synonym: "apoptosis of neutrophils" EXACT [] synonym: "neutrophil programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neutrophils by apoptosis" EXACT [] synonym: "programmed cell death, neutrophils" EXACT [] is_a: GO:0033028 ! myeloid cell apoptosis relationship: part_of GO:0001780 ! neutrophil homeostasis [Term] id: GO:0001782 name: B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12956429] comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "B lymphocyte homeostasis" EXACT [] synonym: "B-cell homeostasis" EXACT [] synonym: "B-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0001783 name: B cell apoptosis namespace: biological_process def: "The process of apoptosis in B cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "apoptosis of B cells" EXACT [] synonym: "apoptosis of B lymphocytes" EXACT [] synonym: "apoptosis of B-cells" EXACT [] synonym: "apoptosis of B-lymphocytes" EXACT [] synonym: "B cell programmed cell death by apoptosis" EXACT [] synonym: "B lymphocyte apoptosis" EXACT [] synonym: "B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "B-cell apoptosis" EXACT [] synonym: "B-cell programmed cell death by apoptosis" EXACT [] synonym: "B-lymphocyte apoptosis" EXACT [] synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of B cells by apoptosis" EXACT [] synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of B-cells by apoptosis" EXACT [] synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, B cells" EXACT [] synonym: "programmed cell death, B lymphocytes" EXACT [] synonym: "programmed cell death, B-cells" EXACT [] synonym: "programmed cell death, B-lymphocytes" EXACT [] is_a: GO:0070227 ! lymphocyte apoptosis [Term] id: GO:0001784 name: phosphotyrosine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein." [PMID:14636584] is_a: GO:0045309 ! protein phosphorylated amino acid binding [Term] id: GO:0001785 name: prostaglandin J receptor activity namespace: molecular_function def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180] synonym: "PGJ receptor activity" RELATED [] synonym: "PGJ(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0001786 name: phosphatidylserine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12000961] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0001787 name: natural killer cell proliferation namespace: biological_process def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "NK cell proliferation" EXACT [] is_a: GO:0030101 ! natural killer cell activation is_a: GO:0046651 ! lymphocyte proliferation [Term] id: GO:0001788 name: antibody-dependent cellular cytotoxicity namespace: biological_process def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [ISBN:0781735149 "Fundamental Immunology", PMID:11677095, PMID:9581795] synonym: "ADCC" EXACT [] synonym: "antibody dependent cell death" EXACT [] synonym: "antibody dependent cell killing" EXACT [] synonym: "antibody-dependent cell death" EXACT [] synonym: "antibody-dependent cell killing" EXACT [] synonym: "type VI hypersensitivity" EXACT [] xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity is_a: GO:0001794 ! type IIa hypersensitivity is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0006917 ! induction of apoptosis [Term] id: GO:0001789 name: G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) namespace: biological_process def: "A G-protein coupled signaling pathway that results in the activation of sphingosine kinase, causing an increase in cellular levels of sphingosine-1-phosphate." [GOC:dph, PMID:14592418] synonym: "G protein signaling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] synonym: "G protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] synonym: "G-protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0001790 name: polymeric immunoglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001791 name: IgM binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001792 name: polymeric immunoglobulin receptor activity namespace: molecular_function def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001790 ! polymeric immunoglobulin binding is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0001793 name: IgM receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgM isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001791 ! IgM binding is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0001794 name: type IIa hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity. is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001795 name: type IIb hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity. synonym: "type V hypersensitivity" EXACT [] is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001796 name: regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001797 name: negative regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type IIa hypersensitivity" EXACT [] synonym: "down-regulation of type IIa hypersensitivity" EXACT [] synonym: "downregulation of type IIa hypersensitivity" EXACT [] synonym: "inhibition of type IIa hypersensitivity" NARROW [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001798 name: positive regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type IIa hypersensitivity" NARROW [] synonym: "stimulation of type IIa hypersensitivity" NARROW [] synonym: "up regulation of type IIa hypersensitivity" EXACT [] synonym: "up-regulation of type IIa hypersensitivity" EXACT [] synonym: "upregulation of type IIa hypersensitivity" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001799 name: regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001800 name: negative regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type IIb hypersensitivity" EXACT [] synonym: "down-regulation of type IIb hypersensitivity" EXACT [] synonym: "downregulation of type IIb hypersensitivity" EXACT [] synonym: "inhibition of type IIb hypersensitivity" NARROW [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001801 name: positive regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type IIb hypersensitivity" NARROW [] synonym: "stimulation of type IIb hypersensitivity" NARROW [] synonym: "up regulation of type IIb hypersensitivity" EXACT [] synonym: "up-regulation of type IIb hypersensitivity" EXACT [] synonym: "upregulation of type IIb hypersensitivity" EXACT [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001802 name: type III hypersensitivity namespace: biological_process def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that the Arthus reaction is an example of type III hypersensitivity. xref: Wikipedia:Type_III_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0001803 name: regulation of type III hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001804 name: negative regulation of type III hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type III hypersensitivity" EXACT [] synonym: "down-regulation of type III hypersensitivity" EXACT [] synonym: "downregulation of type III hypersensitivity" EXACT [] synonym: "inhibition of type III hypersensitivity" NARROW [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response relationship: negatively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001805 name: positive regulation of type III hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type III hypersensitivity" NARROW [] synonym: "stimulation of type III hypersensitivity" NARROW [] synonym: "up regulation of type III hypersensitivity" EXACT [] synonym: "up-regulation of type III hypersensitivity" EXACT [] synonym: "upregulation of type III hypersensitivity" EXACT [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response relationship: positively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001806 name: type IV hypersensitivity namespace: biological_process alt_id: GO:0016069 def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "delayed hypersensitivity response" EXACT [] synonym: "delayed-type hypersensitivity" EXACT [] xref: Wikipedia:Type_IV_hypersensitivity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002524 ! hypersensitivity [Term] id: GO:0001807 name: regulation of type IV hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002883 ! regulation of hypersensitivity relationship: regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001808 name: negative regulation of type IV hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type IV hypersensitivity" EXACT [] synonym: "down-regulation of type IV hypersensitivity" EXACT [] synonym: "downregulation of type IV hypersensitivity" EXACT [] synonym: "inhibition of type IV hypersensitivity" NARROW [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002884 ! negative regulation of hypersensitivity relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001809 name: positive regulation of type IV hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type IV hypersensitivity" NARROW [] synonym: "stimulation of type IV hypersensitivity" NARROW [] synonym: "up regulation of type IV hypersensitivity" EXACT [] synonym: "up-regulation of type IV hypersensitivity" EXACT [] synonym: "upregulation of type IV hypersensitivity" EXACT [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002885 ! positive regulation of hypersensitivity relationship: positively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001810 name: regulation of type I hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001811 name: negative regulation of type I hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type I hypersensitivity" EXACT [] synonym: "down-regulation of type I hypersensitivity" EXACT [] synonym: "downregulation of type I hypersensitivity" EXACT [] synonym: "inhibition of type I hypersensitivity" NARROW [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response relationship: negatively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001812 name: positive regulation of type I hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type I hypersensitivity" NARROW [] synonym: "stimulation of type I hypersensitivity" NARROW [] synonym: "up regulation of type I hypersensitivity" EXACT [] synonym: "up-regulation of type I hypersensitivity" EXACT [] synonym: "upregulation of type I hypersensitivity" EXACT [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response relationship: positively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001813 name: regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of antibody dependent cell death" EXACT [] synonym: "regulation of antibody dependent cell killing" EXACT [] synonym: "regulation of antibody-dependent cell death" EXACT [] synonym: "regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001814 name: negative regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "negative regulation of antibody dependent cell death" EXACT [] synonym: "negative regulation of antibody dependent cell killing" EXACT [] synonym: "negative regulation of antibody-dependent cell death" EXACT [] synonym: "negative regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001815 name: positive regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "positive regulation of antibody dependent cell death" EXACT [] synonym: "positive regulation of antibody dependent cell killing" EXACT [] synonym: "positive regulation of antibody-dependent cell death" EXACT [] synonym: "positive regulation of antibody-dependent cell killing" EXACT [] synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT [] is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001816 name: cytokine production namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. subset: goslim_pir synonym: "interferon production" NARROW [GOC:add, GOC:mah] synonym: "interleukin production" NARROW [GOC:add, GOC:mah] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001817 name: regulation of cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0001816 ! cytokine production [Term] id: GO:0001818 name: negative regulation of cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of cytokine production" EXACT [] synonym: "down-regulation of cytokine production" EXACT [] synonym: "downregulation of cytokine production" EXACT [] synonym: "inhibition of cytokine production" NARROW [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001819 name: positive regulation of cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of cytokine production" NARROW [] synonym: "stimulation of cytokine production" NARROW [] synonym: "up regulation of cytokine production" EXACT [] synonym: "up-regulation of cytokine production" EXACT [] synonym: "upregulation of cytokine production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001820 name: serotonin secretion namespace: biological_process def: "The regulated release of serotonin by a cell or group of cells. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0781735149 "Fundamental Immunology"] synonym: "5-HT secretion" EXACT [] synonym: "5-hydroxytryptamine secretion" EXACT [] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release is_a: GO:0032940 ! secretion by cell [Term] id: GO:0001821 name: histamine secretion namespace: biological_process def: "The regulated release of histamine by a cell or group of cells. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0046903 ! secretion is_a: GO:0051608 ! histamine transport [Term] id: GO:0001822 name: kidney development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "nephrogenesis" RELATED [GOC:dph, GOC:tb] xref: Wikipedia:Kidney_development is_a: GO:0048513 ! organ development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0001823 name: mesonephros development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:10535314] is_a: GO:0001822 ! kidney development [Term] id: GO:0001824 name: blastocyst development namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001701 ! in utero embryonic development [Term] id: GO:0001825 name: blastocyst formation namespace: biological_process def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001826 name: inner cell mass cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001827 name: inner cell mass cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001828 name: inner cell mass cellular morphogenesis namespace: biological_process def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001829 name: trophectodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001830 name: trophectodermal cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell fate commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001832 name: blastocyst growth namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001833 name: inner cell mass cell proliferation namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001834 name: trophectodermal cell proliferation namespace: biological_process def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001835 name: blastocyst hatching namespace: biological_process def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'. is_a: GO:0035188 ! hatching relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001836 name: release of cytochrome c from mitochondria namespace: biological_process def: "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:add, GOC:mah, ISBN:0721639976, PMID:12925707, PMID:9560217] is_a: GO:0008637 ! apoptotic mitochondrial changes [Term] id: GO:0001837 name: epithelial to mesenchymal transition namespace: biological_process def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] synonym: "EMT" EXACT [] synonym: "epithelial-mesenchymal transition" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0014031 ! mesenchymal cell development [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001840 ! neural plate development [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0001841 name: neural tube formation namespace: biological_process alt_id: GO:0001679 def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0001842 name: neural fold formation namespace: biological_process def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] synonym: "neural groove formation" RELATED [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001843 name: neural tube closure namespace: biological_process def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437] is_a: GO:0060606 ! tube closure relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001844 name: protein insertion into mitochondrial membrane involved in induction of apoptosis namespace: biological_process def: "The process in which a protein is incorporated into a mitochondrial membrane, contributing to the induction of apoptosis." [GOC:add, PMID:12952892] comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program. synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" EXACT [] synonym: "protein insertion into mitochondrial membrane during induction of apoptosis" RELATED [GOC:dph, GOC:tb] synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" EXACT [] xref: Reactome:114264 "Translocation of activated BAX to the mitochondria" xref: Reactome:1231577 "Translocation of activated BAX to the mitochondria" xref: Reactome:1231906 "Translocation of activated BAD protein to mitochondria" xref: Reactome:1231934 "Translocation of BMF to mitochondria" xref: Reactome:1231941 "Translocation of PUMA protein to mitochondria" xref: Reactome:1231948 "Translocation of BIM to mitochondria" xref: Reactome:1259340 "Translocation of activated BAX to the mitochondria" xref: Reactome:1259636 "Translocation of activated BAD protein to mitochondria" xref: Reactome:1259655 "Translocation of BMF to mitochondria" xref: Reactome:1259662 "Translocation of PUMA protein to mitochondria" xref: Reactome:1259678 "Translocation of BIM to mitochondria" xref: Reactome:1284731 "Translocation of activated BAX to the mitochondria" xref: Reactome:1285024 "Translocation of activated BAD protein to mitochondria" xref: Reactome:1285060 "Translocation of BIM to mitochondria" xref: Reactome:1305295 "Translocation of activated BAX to the mitochondria" xref: Reactome:1305597 "Translocation of activated BAD protein to mitochondria" xref: Reactome:1305624 "Translocation of BMF to mitochondria" xref: Reactome:1305640 "Translocation of BIM to mitochondria" xref: Reactome:1332866 "Translocation of activated BAX to the mitochondria" xref: Reactome:1333163 "Translocation of activated BAD protein to mitochondria" xref: Reactome:1333181 "Translocation of BMF to mitochondria" xref: Reactome:1333196 "Translocation of BIM to mitochondria" xref: Reactome:1357596 "Translocation of BMF to mitochondria" xref: Reactome:1378414 "Translocation of activated BAX to the mitochondria" xref: Reactome:1378605 "Translocation of BMF to mitochondria" xref: Reactome:1398853 "Translocation of activated BAX to the mitochondria" xref: Reactome:139905 "Translocation of activated BAD protein to mitochondria" xref: Reactome:139909 "Translocation of BMF to mitochondria" xref: Reactome:139914 "Translocation of PUMA protein to mitochondria" xref: Reactome:1399149 "Translocation of BMF to mitochondria" xref: Reactome:139919 "Translocation of BIM to mitochondria" xref: Reactome:140216 "Translocation of NOXA to mitochondria" xref: Reactome:1425348 "Translocation of activated BAX to the mitochondria" xref: Reactome:1425783 "Translocation of activated BAD protein to mitochondria" is_a: GO:0008637 ! apoptotic mitochondrial changes is_a: GO:0051204 ! protein insertion into mitochondrial membrane relationship: part_of GO:0006917 ! induction of apoptosis [Term] id: GO:0001845 name: phagolysosome assembly namespace: biological_process def: "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "late phagosome biosynthesis" RELATED [] synonym: "late phagosome formation" RELATED [] synonym: "phagolysosome formation" RELATED [GOC:mah] is_a: GO:0006906 ! vesicle fusion is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0006909 ! phagocytosis relationship: part_of GO:0090382 ! phagosome maturation [Term] id: GO:0001846 name: opsonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. is_a: GO:0005515 ! protein binding [Term] id: GO:0001847 name: opsonin receptor activity namespace: molecular_function def: "Combining with an opsonin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0001848 name: complement binding namespace: molecular_function def: "Interacting selectively and non-covalently with any component or product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. is_a: GO:0005515 ! protein binding [Term] id: GO:0001849 name: complement component C1q binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001850 name: complement component C3a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001848 ! complement binding [Term] id: GO:0001851 name: complement component C3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001852 name: complement component iC3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001853 name: complement component C3dg binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001848 ! complement binding [Term] id: GO:0001854 name: complement component C3d binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001848 ! complement binding [Term] id: GO:0001855 name: complement component C4b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001856 name: complement component C5a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001848 ! complement binding [Term] id: GO:0001857 name: complement component C1q receptor activity namespace: molecular_function def: "Combining with the C1q component of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001849 ! complement component C1q binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001858 name: complement component iC3b receptor activity namespace: molecular_function def: "Combining with the iC3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001852 ! complement component iC3b binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001859 name: complement component C3dg receptor activity namespace: molecular_function def: "Combining with the C3dg product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001860 name: complement component C3d receptor activity namespace: molecular_function def: "Combining with the C3d product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001861 name: complement component C4b receptor activity namespace: molecular_function def: "Combining with the C4b product of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001855 ! complement component C4b binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001862 name: collectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001863 name: collectin receptor activity namespace: molecular_function def: "Combining with a collectin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001847 ! opsonin receptor activity [Term] id: GO:0001864 name: pentraxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001865 name: NK T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer T cell differentiation" EXACT [] synonym: "natural T cell differentiation" EXACT [] synonym: "NK T cell development" RELATED [GOC:add] synonym: "NK T lymphocyte differentiation" EXACT [] synonym: "NK T-cell differentiation" EXACT [] synonym: "NK T-lymphocyte differentiation" EXACT [] synonym: "NKT cell differentiation" EXACT [] synonym: "NT cell differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0001866 name: NK T cell proliferation namespace: biological_process def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. synonym: "natural killer T cell proliferation" EXACT [] synonym: "natural T cell proliferation" EXACT [] synonym: "NK T lymphocyte proliferation" EXACT [] synonym: "NK T-cell proliferation" EXACT [] synonym: "NK T-lymphocyte proliferation" EXACT [] synonym: "NKT cell proliferation" EXACT [] synonym: "NT cell proliferation" EXACT [] is_a: GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0001867 name: complement activation, lectin pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway. synonym: "complement cascade, lectin pathway" EXACT [GOC:add] xref: Reactome:1280293 "Lectin pathway of complement activation" xref: Reactome:1299144 "Lectin pathway of complement activation" xref: Reactome:1326871 "Lectin pathway of complement activation" xref: Reactome:1352963 "Lectin pathway of complement activation" xref: Reactome:1373165 "Lectin pathway of complement activation" xref: Reactome:1450769 "Lectin pathway of complement activation" xref: Reactome:166662 "Lectin pathway of complement activation" is_a: GO:0006956 ! complement activation is_a: GO:0045087 ! innate immune response [Term] id: GO:0001868 name: regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0030449 ! regulation of complement activation is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001869 name: negative regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of complement activation, lectin pathway" EXACT [] synonym: "down-regulation of complement activation, lectin pathway" EXACT [] synonym: "downregulation of complement activation, lectin pathway" EXACT [] synonym: "inhibition of complement activation, lectin pathway" NARROW [] synonym: "negative regulation of complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0045916 ! negative regulation of complement activation relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001870 name: positive regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of complement activation, lectin pathway" NARROW [] synonym: "positive regulation of complement cascade, lectin pathway" EXACT [GOC:add] synonym: "stimulation of complement activation, lectin pathway" NARROW [] synonym: "up regulation of complement activation, lectin pathway" EXACT [] synonym: "up-regulation of complement activation, lectin pathway" EXACT [] synonym: "upregulation of complement activation, lectin pathway" EXACT [] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0045917 ! positive regulation of complement activation relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001871 name: pattern binding namespace: molecular_function def: "Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544] comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead. subset: goslim_pir subset: gosubset_prok synonym: "pattern recognition activity" BROAD [] is_a: GO:0005488 ! binding [Term] id: GO:0001872 name: 1,3-beta-D-glucan binding namespace: molecular_function def: "Interacting selectively and non-covalently with 1,3-beta-D-glucans." [PMID:14707091] synonym: "zymosan binding" NARROW [GOC:tb] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0001873 name: polysaccharide receptor activity namespace: molecular_function def: "Combining with a polysaccharide to initiate a change in cell activity." [PMID:14707091] is_a: GO:0008329 ! pattern recognition receptor activity is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0001874 name: 1,3-beta-D-glucan receptor activity namespace: molecular_function def: "Combining with 1,3-beta-D glucans to initiate a change in cell activity." [PMID:14707091] synonym: "(1->3)-beta-D-glucan receptor" EXACT [] synonym: "zymosan receptor activity" NARROW [GOC:tb] is_a: GO:0001872 ! 1,3-beta-D-glucan binding is_a: GO:0001873 ! polysaccharide receptor activity [Term] id: GO:0001875 name: lipopolysaccharide receptor activity namespace: molecular_function def: "Combining with a lipopolysaccharide to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975] synonym: "endotoxin receptor activity" BROAD [] synonym: "LPS receptor activity" EXACT [] is_a: GO:0001530 ! lipopolysaccharide binding is_a: GO:0008329 ! pattern recognition receptor activity [Term] id: GO:0001876 name: lipoarabinomannan binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoarabinomannan." [PMID:10586073] synonym: "LAM binding" EXACT [] is_a: GO:0001871 ! pattern binding [Term] id: GO:0001877 name: lipoarabinomannan receptor activity namespace: molecular_function def: "Combining with lipoarabinomannan to initiate a change in cell activity." [PMID:10586073] synonym: "LAM receptor activity" EXACT [] is_a: GO:0001876 ! lipoarabinomannan binding is_a: GO:0008329 ! pattern recognition receptor activity [Term] id: GO:0001878 name: response to yeast namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] is_a: GO:0009620 ! response to fungus [Term] id: GO:0001879 name: detection of yeast namespace: biological_process def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091] is_a: GO:0001878 ! response to yeast is_a: GO:0016046 ! detection of fungus [Term] id: GO:0001880 name: Mullerian duct regression namespace: biological_process def: "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0001881 name: receptor recycling namespace: biological_process def: "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph] is_a: GO:0043112 ! receptor metabolic process relationship: part_of GO:0023051 ! regulation of signaling [Term] id: GO:0001882 name: nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0001883 name: purine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001884 name: pyrimidine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001885 name: endothelial cell development namespace: biological_process def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0045446 ! endothelial cell differentiation [Term] id: GO:0001886 name: endothelial cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis relationship: part_of GO:0001885 ! endothelial cell development [Term] id: GO:0001887 name: selenium compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine." [PMID:12730456] subset: gosubset_prok synonym: "selenium compound metabolism" EXACT [] synonym: "selenium metabolic process" EXACT [] synonym: "selenium metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0001888 name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223] synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223] synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] xref: EC:2.4.1.223 xref: MetaCyc:2.4.1.223-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0001889 name: liver development namespace: biological_process def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] is_a: GO:0048513 ! organ development relationship: part_of GO:0061008 ! hepaticobiliary system development [Term] id: GO:0001890 name: placenta development namespace: biological_process def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] synonym: "placental development" EXACT [] synonym: "placentation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048513 ! organ development [Term] id: GO:0001891 name: phagocytic cup namespace: cellular_component def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0001892 name: embryonic placenta development namespace: biological_process def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] synonym: "fetal placenta development" EXACT [GOC:dph] is_a: GO:0048568 ! embryonic organ development relationship: part_of GO:0001701 ! in utero embryonic development relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001893 name: maternal placenta development namespace: biological_process def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] synonym: "decidua development" RELATED [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001894 name: tissue homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] synonym: "tissue maintenance" NARROW [GOC:add] is_a: GO:0060249 ! anatomical structure homeostasis relationship: part_of GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001895 name: retina homeostasis namespace: biological_process def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178] is_a: GO:0001894 ! tissue homeostasis [Term] id: GO:0001896 name: autolysis namespace: biological_process def: "The spontaneous death by lysis of bacteria in response to environmental conditions." [GOC:add] subset: gosubset_prok xref: Wikipedia:Autolysis is_a: GO:0019835 ! cytolysis [Term] id: GO:0001897 name: cytolysis by symbiont of host cells namespace: biological_process def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "cytolysis by organism of host cells" EXACT [] is_a: GO:0001907 ! killing by symbiont of host cells is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction is_a: GO:0052025 ! modification by symbiont of host cell membrane [Term] id: GO:0001898 name: regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001899 name: negative regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "down regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "downregulation by symbiont of cytolysis of host cells" EXACT [] synonym: "inhibition by symbiont of cytolysis of host cells" NARROW [] synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051803 ! negative regulation of cytolysis in other organism involved in symbiotic interaction relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001900 name: positive regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "activation by symbiont of cytolysis of host cells" NARROW [] synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] synonym: "stimulation by symbiont of cytolysis of host cells" NARROW [] synonym: "up regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "upregulation by symbiont of cytolysis of host cells" EXACT [] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051804 ! positive regulation of cytolysis in other organism involved in symbiotic interaction relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001905 name: activation of membrane attack complex namespace: biological_process def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of MAC" EXACT [] synonym: "activation of TCC" NARROW [] synonym: "activation of terminal complement complex" NARROW [GOC:add] synonym: "activation of the terminal complement cascade" NARROW [] synonym: "MAC assembly" EXACT [GOC:rl] synonym: "MAC formation" EXACT [GOC:rl] synonym: "membrane attack complex assembly" EXACT [GOC:rl] synonym: "membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0006956 ! complement activation [Term] id: GO:0001906 name: cell killing namespace: biological_process def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir subset: gosubset_prok synonym: "necrosis" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0001907 name: killing by symbiont of host cells namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok is_a: GO:0044004 ! disruption by symbiont of host cells is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0001909 name: leukocyte mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. synonym: "immune cell mediated cell death" EXACT [] synonym: "immune cell mediated cell killing" EXACT [] synonym: "immune cell mediated cytotoxicity" EXACT [] synonym: "leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001906 ! cell killing is_a: GO:0002252 ! immune effector process [Term] id: GO:0001910 name: regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] synonym: "regulation of immune cell mediated cell death" EXACT [] synonym: "regulation of immune cell mediated cell killing" EXACT [] synonym: "regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0031341 ! regulation of cell killing relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001911 name: negative regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW [] synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0031342 ! negative regulation of cell killing relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001912 name: positive regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] synonym: "activation of leukocyte mediated cytotoxicity" NARROW [] synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW [] synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0031343 ! positive regulation of cell killing relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001913 name: T cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. synonym: "T cell mediated apoptosis" EXACT [] synonym: "T cell mediated cell death" EXACT [] synonym: "T cell mediated cell killing" EXACT [] synonym: "T cell mediated cytolysis" RELATED [] synonym: "T lymphocyte mediated cytotoxicity" EXACT [] synonym: "T-cell mediated apoptosis" EXACT [] synonym: "T-cell mediated cell death" EXACT [] synonym: "T-cell mediated cell killing" EXACT [] synonym: "T-cell mediated cytotoxicity" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0006917 ! induction of apoptosis [Term] id: GO:0001914 name: regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of T cell mediated apoptosis" EXACT [] synonym: "regulation of T cell mediated cell death" EXACT [] synonym: "regulation of T cell mediated cell killing" EXACT [] synonym: "regulation of T cell mediated cytolysis" RELATED [] synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "regulation of T-cell mediated apoptosis" EXACT [] synonym: "regulation of T-cell mediated cell death" EXACT [] synonym: "regulation of T-cell mediated cell killing" EXACT [] synonym: "regulation of T-cell mediated cytolysis" RELATED [] synonym: "regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002709 ! regulation of T cell mediated immunity relationship: regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001915 name: negative regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of T cell mediated cytotoxicity" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity" NARROW [] synonym: "negative regulation of T cell mediated apoptosis" EXACT [] synonym: "negative regulation of T cell mediated cell death" EXACT [] synonym: "negative regulation of T cell mediated cell killing" EXACT [] synonym: "negative regulation of T cell mediated cytolysis" RELATED [] synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-cell mediated apoptosis" EXACT [] synonym: "negative regulation of T-cell mediated cell death" EXACT [] synonym: "negative regulation of T-cell mediated cell killing" EXACT [] synonym: "negative regulation of T-cell mediated cytolysis" RELATED [] synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002710 ! negative regulation of T cell mediated immunity relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001916 name: positive regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of T cell mediated cytotoxicity" NARROW [] synonym: "positive regulation of T cell mediated apoptosis" EXACT [] synonym: "positive regulation of T cell mediated cell death" EXACT [] synonym: "positive regulation of T cell mediated cell killing" EXACT [] synonym: "positive regulation of T cell mediated cytolysis" RELATED [] synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-cell mediated apoptosis" EXACT [] synonym: "positive regulation of T-cell mediated cell death" EXACT [] synonym: "positive regulation of T-cell mediated cell killing" EXACT [] synonym: "positive regulation of T-cell mediated cytolysis" RELATED [] synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of T cell mediated cytotoxicity" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity" EXACT [] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002711 ! positive regulation of T cell mediated immunity relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001917 name: photoreceptor inner segment namespace: cellular_component def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563] subset: goslim_pir is_a: GO:0044464 ! cell part [Term] id: GO:0001918 name: farnesylated protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a farnesylated protein." [GOC:add, PMID:14555765] is_a: GO:0005515 ! protein binding [Term] id: GO:0001919 name: regulation of receptor recycling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add] is_a: GO:0023051 ! regulation of signaling is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0001881 ! receptor recycling [Term] id: GO:0001920 name: negative regulation of receptor recycling namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add] synonym: "down regulation of receptor recycling" EXACT [] synonym: "down-regulation of receptor recycling" EXACT [] synonym: "downregulation of receptor recycling" EXACT [] synonym: "inhibition of receptor recycling" NARROW [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0031324 ! negative regulation of cellular metabolic process relationship: negatively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001921 name: positive regulation of receptor recycling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add] synonym: "activation of receptor recycling" NARROW [] synonym: "stimulation of receptor recycling" NARROW [] synonym: "up regulation of receptor recycling" EXACT [] synonym: "up-regulation of receptor recycling" EXACT [] synonym: "upregulation of receptor recycling" EXACT [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0031325 ! positive regulation of cellular metabolic process relationship: positively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001922 name: B-1 B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus. synonym: "B-1 B lymphocyte homeostasis" EXACT [] synonym: "B-1 B-cell homeostasis" EXACT [] synonym: "B-1 B-lymphocyte homeostasis" EXACT [] is_a: GO:0001782 ! B cell homeostasis [Term] id: GO:0001923 name: B-1 B cell differentiation namespace: biological_process def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "B-1 B cell development" RELATED [GOC:add] synonym: "B-1 B lymphocyte differentiation" EXACT [] synonym: "B-1 B-cell differentiation" EXACT [] synonym: "B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0001924 name: regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of B-1 B cell development" RELATED [GOC:add] synonym: "regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "regulation of B-1 B-cell differentiation" EXACT [] synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation relationship: regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001925 name: negative regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of B-1 B cell differentiation" EXACT [] synonym: "down-regulation of B-1 B cell differentiation" EXACT [] synonym: "downregulation of B-1 B cell differentiation" EXACT [] synonym: "inhibition of B-1 B cell differentiation" NARROW [] synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add] synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "negative regulation of B-1 B-cell differentiation" EXACT [] synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045578 ! negative regulation of B cell differentiation relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001926 name: positive regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of B-1 B cell differentiation" NARROW [] synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add] synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "positive regulation of B-1 B-cell differentiation" EXACT [] synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT [] synonym: "stimulation of B-1 B cell differentiation" NARROW [] synonym: "up regulation of B-1 B cell differentiation" EXACT [] synonym: "up-regulation of B-1 B cell differentiation" EXACT [] synonym: "upregulation of B-1 B cell differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045579 ! positive regulation of B cell differentiation relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001927 name: exocyst assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, PMID:9700152, Wikipedia:Exocyst] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006904 ! vesicle docking involved in exocytosis [Term] id: GO:0001928 name: regulation of exocyst assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd] comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0043254 ! regulation of protein complex assembly relationship: regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001929 name: negative regulation of exocyst assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of exocyst assembly." [GOC:hjd] synonym: "down regulation of exocyst assembly" EXACT [] synonym: "down-regulation of exocyst assembly" EXACT [] synonym: "downregulation of exocyst assembly" EXACT [] synonym: "inhibition of exocyst assembly" NARROW [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001930 name: positive regulation of exocyst assembly namespace: biological_process def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd] synonym: "activation of exocyst assembly" NARROW [] synonym: "stimulation of exocyst assembly" NARROW [] synonym: "up regulation of exocyst assembly" EXACT [] synonym: "up-regulation of exocyst assembly" EXACT [] synonym: "upregulation of exocyst assembly" EXACT [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001931 name: uropod namespace: cellular_component def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12714569, PMID:12787750] synonym: "distal pole complex" RELATED [] synonym: "retractile pole" RELATED [] synonym: "uropodium" EXACT [] is_a: GO:0042995 ! cell projection relationship: part_of GO:0031254 ! trailing edge [Term] id: GO:0001932 name: regulation of protein phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] subset: gosubset_prok synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation relationship: regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001933 name: negative regulation of protein phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gosubset_prok synonym: "down regulation of protein amino acid phosphorylation" EXACT [] synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] synonym: "downregulation of protein amino acid phosphorylation" EXACT [] synonym: "inhibition of protein amino acid phosphorylation" NARROW [] synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0042326 ! negative regulation of phosphorylation relationship: negatively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001934 name: positive regulation of protein phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gosubset_prok synonym: "activation of protein amino acid phosphorylation" NARROW [] synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid phosphorylation" NARROW [] synonym: "up regulation of protein amino acid phosphorylation" EXACT [] synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] synonym: "upregulation of protein amino acid phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0042327 ! positive regulation of phosphorylation relationship: positively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001935 name: endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0050673 ! epithelial cell proliferation [Term] id: GO:0001936 name: regulation of endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation relationship: regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "down regulation of endothelial cell proliferation" EXACT [] synonym: "down-regulation of endothelial cell proliferation" EXACT [] synonym: "downregulation of endothelial cell proliferation" EXACT [] synonym: "inhibition of endothelial cell proliferation" NARROW [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "activation of endothelial cell proliferation" NARROW [] synonym: "stimulation of endothelial cell proliferation" NARROW [] synonym: "up regulation of endothelial cell proliferation" EXACT [] synonym: "up-regulation of endothelial cell proliferation" EXACT [] synonym: "upregulation of endothelial cell proliferation" EXACT [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation relationship: positively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001939 name: female pronucleus namespace: cellular_component def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001940 name: male pronucleus namespace: cellular_component def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001941 name: postsynaptic membrane organization namespace: biological_process def: "The maintenance of membrane composition in a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph] synonym: "postsynaptic membrane organisation" EXACT [GOC:curators] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0001942 name: hair follicle development namespace: biological_process alt_id: GO:0001943 def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073] is_a: GO:0008544 ! epidermis development is_a: GO:0022405 ! hair cycle process [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" EXACT [GOC:curators] is_a: GO:0048731 ! system development relationship: part_of GO:0072358 ! cardiovascular system development [Term] id: GO:0001945 name: lymph vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001946 name: lymphangiogenesis namespace: biological_process def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157] synonym: "lymph vessel formation" EXACT systematic_synonym [] xref: Wikipedia:Lymphangiogenesis is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0001945 ! lymph vessel development [Term] id: GO:0001947 name: heart looping namespace: biological_process def: "The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration." [GOC:dph, PMID:12094232] synonym: "cardiac looping" EXACT [] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis relationship: part_of GO:0061371 ! determination of heart left/right asymmetry [Term] id: GO:0001948 name: glycoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005515 ! protein binding [Term] id: GO:0001949 name: sebaceous gland cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203] synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0048733 ! sebaceous gland development [Term] id: GO:0001950 name: plasma membrane enriched fraction namespace: cellular_component def: "The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832] synonym: "PME fraction" RELATED [GOC:mah] is_a: GO:0000267 ! cell fraction relationship: part_of GO:0005624 ! membrane fraction [Term] id: GO:0001951 name: intestinal D-glucose absorption namespace: biological_process def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832] is_a: GO:0015758 ! glucose transport is_a: GO:0050892 ! intestinal absorption [Term] id: GO:0001952 name: regulation of cell-matrix adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] is_a: GO:0010810 ! regulation of cell-substrate adhesion relationship: regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001953 name: negative regulation of cell-matrix adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd] synonym: "down regulation of cell-matrix adhesion" EXACT [] synonym: "down-regulation of cell-matrix adhesion" EXACT [] synonym: "downregulation of cell-matrix adhesion" EXACT [] synonym: "inhibition of cell-matrix adhesion" NARROW [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010812 ! negative regulation of cell-substrate adhesion relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001954 name: positive regulation of cell-matrix adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd] synonym: "activation of cell-matrix adhesion" NARROW [] synonym: "stimulation of cell-matrix adhesion" NARROW [] synonym: "up regulation of cell-matrix adhesion" EXACT [] synonym: "up-regulation of cell-matrix adhesion" EXACT [] synonym: "upregulation of cell-matrix adhesion" EXACT [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010811 ! positive regulation of cell-substrate adhesion relationship: positively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001955 name: blood vessel maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] synonym: "activation of neurotransmitter secretion" NARROW [] synonym: "stimulation of neurotransmitter secretion" NARROW [] synonym: "up regulation of neurotransmitter secretion" EXACT [] synonym: "up-regulation of neurotransmitter secretion" EXACT [] synonym: "upregulation of neurotransmitter secretion" EXACT [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051590 ! positive regulation of neurotransmitter transport relationship: positively_regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0001957 name: intramembranous ossification namespace: biological_process def: "The formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified. Intramembranous ossification is the way flat bones and the shell of a turtle are formed." [ISBN:0878932437] xref: Wikipedia:Intramembranous_ossification is_a: GO:0001503 ! ossification [Term] id: GO:0001958 name: endochondral ossification namespace: biological_process def: "The formation of bone by the replacement of cartilage tissue with mineralized bone." [ISBN:0878932437] xref: Wikipedia:Endochondral_ossification is_a: GO:0001503 ! ossification relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0001959 name: regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0060759 ! regulation of response to cytokine stimulus relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001960 name: negative regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "down regulation of cytokine mediated signaling pathway" EXACT [] synonym: "down-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "downregulation of cytokine mediated signaling pathway" EXACT [] synonym: "inhibition of cytokine mediated signaling pathway" NARROW [] synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060761 ! negative regulation of response to cytokine stimulus relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001961 name: positive regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd] synonym: "activation of cytokine mediated signaling pathway" NARROW [] synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of cytokine mediated signalling pathway" EXACT [] synonym: "stimulation of cytokine mediated signaling pathway" NARROW [] synonym: "up regulation of cytokine mediated signaling pathway" EXACT [] synonym: "up-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "upregulation of cytokine mediated signaling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060760 ! positive regulation of response to cytokine stimulus relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001962 name: alpha-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:hjd, PMID:10854427] synonym: "isoglobotriaosylceramide synthase" NARROW [] xref: EC:2.4.1.- is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0001963 name: synaptic transmission, dopaminergic namespace: biological_process def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:dph] is_a: GO:0007270 ! neuron-neuron synaptic transmission [Term] id: GO:0001964 name: startle response namespace: biological_process def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] xref: Wikipedia:Startle_reaction is_a: GO:0009605 ! response to external stimulus is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0001965 name: G-protein alpha-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] synonym: "G-alpha protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0001966 name: thigmotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph] synonym: "stereotaxis" EXACT [] synonym: "taxis in response to mechanical stimulus" BROAD [] synonym: "taxis in response to touch stimulus" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0001967 name: suckling behavior namespace: biological_process def: "Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast." [GOC:dph] synonym: "nursing behavior" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0051705 ! behavioral interaction between organisms [Term] id: GO:0001968 name: fibronectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0001969 name: regulation of activation of membrane attack complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "regulation of activation of MAC" EXACT [GOC:mah] synonym: "regulation of activation of TCC" NARROW [GOC:mah] synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "regulation of MAC assembly" EXACT [GOC:rl] synonym: "regulation of MAC formation" EXACT [GOC:rl] synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0030449 ! regulation of complement activation relationship: regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001970 name: positive regulation of activation of membrane attack complex namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "activation of activation of membrane attack complex" NARROW [] synonym: "positive regulation of activation of MAC" EXACT [GOC:mah] synonym: "positive regulation of activation of TCC" NARROW [GOC:mah] synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "positive regulation of MAC assembly" EXACT [GOC:rl] synonym: "positive regulation of MAC formation" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl] synonym: "stimulation of activation of membrane attack complex" NARROW [] synonym: "up regulation of activation of membrane attack complex" EXACT [] synonym: "up-regulation of activation of membrane attack complex" EXACT [] synonym: "upregulation of activation of membrane attack complex" EXACT [] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045917 ! positive regulation of complement activation relationship: positively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001971 name: negative regulation of activation of membrane attack complex namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "down regulation of activation of membrane attack complex" EXACT [] synonym: "down-regulation of activation of membrane attack complex" EXACT [] synonym: "downregulation of activation of membrane attack complex" EXACT [] synonym: "inhibition of activation of membrane attack complex" NARROW [] synonym: "negative regulation of activation of MAC" EXACT [GOC:mah] synonym: "negative regulation of activation of TCC" NARROW [GOC:mah] synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "negative regulation of MAC assembly" EXACT [GOC:rl] synonym: "negative regulation of MAC formation" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045916 ! negative regulation of complement activation relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001972 name: retinoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd] is_a: GO:0005501 ! retinoid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0001973 name: adenosine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph] synonym: "adenosine receptor signaling pathway, G-protein coupled" EXACT [PMID:9755289] synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah] synonym: "P1 receptor signaling pathway" EXACT [PMID:9755289] is_a: GO:0035588 ! G-protein coupled purinergic receptor signaling pathway [Term] id: GO:0001974 name: blood vessel remodeling namespace: biological_process def: "The reorganization or renovation of existing blood vessels." [GOC:hjd] is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0001975 name: response to amphetamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [CHEBI:2679, GOC:dph, GOC:ef] is_a: GO:0014075 ! response to amine stimulus [Term] id: GO:0001976 name: neurological system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by neurological process" EXACT [] synonym: "fast control of arterial pressure" RELATED [] synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0001977 name: renal system process involved in regulation of blood volume namespace: biological_process def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "renal blood volume control of blood pressure" RELATED [] synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0050878 ! regulation of body fluid levels [Term] id: GO:0001978 name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "baroreceptor feedback control of blood pressure" RELATED [] synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X "Stedman's Medical Dictionary"] synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0001979 name: regulation of systemic arterial blood pressure by chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "chemoreceptor control of blood pressure" RELATED [] synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001980 name: regulation of systemic arterial blood pressure by ischemic conditions namespace: biological_process def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "CNS ischemic response" RELATED [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "ischemic control of blood pressure" RELATED [] synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001981 name: baroreceptor detection of arterial stretch namespace: biological_process def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0001982 name: baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology", ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0001983 name: baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology", ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0001984 name: vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001985 name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW [] synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED [] synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001986 name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT [] synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0045822 ! negative regulation of heart contraction relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001987 name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001988 name: positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED [] synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001989 name: positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [] synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED [] synonym: "positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [GOC:tb] is_a: GO:0045823 ! positive regulation of heart contraction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001990 name: regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by hormone" EXACT [] synonym: "hormonal control of blood pressure" RELATED [] synonym: "hormonal regulation of blood pressure" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal is_a: GO:0050886 ! endocrine process [Term] id: GO:0001991 name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin namespace: biological_process def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT [] synonym: "circulatory renin-angiotensin control of blood pressure" RELATED [] synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT [] synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED [] synonym: "renin-angiotensin blood pressure control" RELATED [] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0001992 name: regulation of systemic arterial blood pressure by vasopressin namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by vasopressin" EXACT [] synonym: "vasopressin control of blood pressure" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0001993 name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED [] synonym: "norepinephrine-epinephrine blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0001994 name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED [] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001995 name: norepinephrine-epinephrine catabolic process in blood stream namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd] synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT [] is_a: GO:0042419 ! epinephrine catabolic process relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0001996 name: positive regulation of heart rate by epinephrine-norepinephrine namespace: biological_process def: "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph] synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED [] synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001997 name: positive regulation of the force of heart contraction by epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio] synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT [] synonym: "increased inotropy by epinephrine-norepinephrine " RELATED [] synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001998 name: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED [] synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT [] synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED [] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin [Term] id: GO:0001999 name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure namespace: biological_process def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph] synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED [] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002000 name: detection of renal blood flow namespace: biological_process def: "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002001 name: renin secretion into blood stream namespace: biological_process def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "renin release into blood stream" EXACT [] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002002 name: regulation of angiotensin levels in blood namespace: biological_process def: "The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin." [GOC:dph] synonym: "control of angiotensin levels in blood" RELATED [] synonym: "control of blood angiotensin level" RELATED [] synonym: "regulation of blood angiotensin level" EXACT [] is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0060177 ! regulation of angiotensin metabolic process relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002003 name: angiotensin maturation namespace: biological_process def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0016486 ! peptide hormone processing relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood [Term] id: GO:0002004 name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure namespace: biological_process def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "secretion of vasopressin during fast control of blood pressure" RELATED [] synonym: "secretion of vasopressin during fast regulation of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0030103 ! vasopressin secretion relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002005 name: angiotensin catabolic process in blood namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0044254 ! multicellular organismal protein catabolic process relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood [Term] id: GO:0002006 name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002007 name: detection of hypoxic conditions in blood by chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph] synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0010850 ! chemoreceptor signaling pathway involved in regulation of blood pressure is_a: GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0002008 name: excitation of vasomotor center by chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT [] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0002010 name: excitation of vasomotor center by baroreceptor signaling namespace: biological_process def: "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT [] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0002012 name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0002013 name: detection of carbon dioxide by vasomotor center namespace: biological_process def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002014 name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure namespace: biological_process def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002015 name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback namespace: biological_process def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb] synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "atrial control of blood pressure" RELATED [] synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio] synonym: "atrial reflex" RELATED [GOC:dph] is_a: GO:0003015 ! heart process relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0002016 name: regulation of blood volume by renin-angiotensin namespace: biological_process def: "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "renin-angiotensin control of body fluid levels" RELATED [] synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0002017 name: regulation of blood volume by renal aldosterone namespace: biological_process def: "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "aldosterone mediated control of body fluids" RELATED [] synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002018 name: renin-angiotensin regulation of aldosterone production namespace: biological_process def: "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "renin-angiotensin control of aldosterone production" RELATED [] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002019 name: regulation of renal output by angiotensin namespace: biological_process def: "The process in which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "angiotensin mediated control of renal output" RELATED [] synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002020 name: protease binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protease or peptidase." [GOC:hjd] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0002021 name: response to dietary excess namespace: biological_process def: "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure." [PMID:12161655] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0050896 ! response to stimulus relationship: part_of GO:0040014 ! regulation of multicellular organism growth [Term] id: GO:0002022 name: detection of dietary excess namespace: biological_process def: "The neurological process in which the brain senses excessive caloric intake." [PMID:12161655] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002023 name: reduction of food intake in response to dietary excess namespace: biological_process def: "The specific actions of an organism that are triggered by the detection of dietary excess and result in a decreased intake of food." [PMID:12161655] is_a: GO:0042755 ! eating behavior relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002024 name: diet induced thermogenesis namespace: biological_process def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655] is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002025 name: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008] synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT [] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0002026 name: regulation of the force of heart contraction namespace: biological_process def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb] synonym: "heart inotropy" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002027 name: regulation of heart rate namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002028 name: regulation of sodium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] synonym: "regulation of Na+ transport" EXACT [] synonym: "regulation of sodium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport relationship: regulates GO:0006814 ! sodium ion transport [Term] id: GO:0002029 name: desensitization of G-protein coupled receptor protein signaling pathway namespace: biological_process def: "The process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway." [PMID:8396717] synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] is_a: GO:0022401 ! negative adaptation of signaling pathway is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway [Term] id: GO:0002030 name: inhibitory G-protein coupled receptor phosphorylation namespace: biological_process def: "The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway [Term] id: GO:0002031 name: G-protein coupled receptor internalization namespace: biological_process def: "The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle." [PMID:8396717] is_a: GO:0031623 ! receptor internalization relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway [Term] id: GO:0002032 name: desensitization of G-protein coupled receptor protein signaling pathway by arrestin namespace: biological_process def: "The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717] synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway is_a: GO:0032091 ! negative regulation of protein binding [Term] id: GO:0002033 name: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the size of a blood vessel via the renin-angiotensin system." [ISBN:0323031951 "Principles of Physiology", PMID:10425188] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin [Term] id: GO:0002034 name: regulation of blood vessel size by renin-angiotensin namespace: biological_process def: "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:tb] synonym: "renin-angiotensin regulation of blood vessel size" EXACT [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin is_a: GO:0050880 ! regulation of blood vessel size [Term] id: GO:0002035 name: brain renin-angiotensin system namespace: biological_process def: "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002036 name: regulation of L-glutamate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-glutamate transport." [GOC:hjd] is_a: GO:0044070 ! regulation of anion transport is_a: GO:0051955 ! regulation of amino acid transport relationship: regulates GO:0015813 ! L-glutamate transport [Term] id: GO:0002037 name: negative regulation of L-glutamate transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate transport." [GOC:hjd] synonym: "down regulation of L-glutamate transport" EXACT [] synonym: "down-regulation of L-glutamate transport" EXACT [] synonym: "downregulation of L-glutamate transport" EXACT [] synonym: "inhibition of L-glutamate transport" NARROW [] is_a: GO:0002036 ! regulation of L-glutamate transport is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051956 ! negative regulation of amino acid transport relationship: negatively_regulates GO:0015813 ! L-glutamate transport [Term] id: GO:0002038 name: positive regulation of L-glutamate transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-glutamate transport." [GOC:hjd] synonym: "activation of L-glutamate transport" NARROW [] synonym: "stimulation of L-glutamate transport" NARROW [] synonym: "up regulation of L-glutamate transport" EXACT [] synonym: "up-regulation of L-glutamate transport" EXACT [] synonym: "upregulation of L-glutamate transport" EXACT [] is_a: GO:0002036 ! regulation of L-glutamate transport is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051957 ! positive regulation of amino acid transport relationship: positively_regulates GO:0015813 ! L-glutamate transport [Term] id: GO:0002039 name: p53 binding namespace: molecular_function def: "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0002040 name: sprouting angiogenesis namespace: biological_process def: "The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells." [PMID:16391003] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002041 name: intussusceptive angiogenesis namespace: biological_process def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002042 name: cell migration involved in sprouting angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002043 name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis namespace: biological_process def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003] synonym: "blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0001935 ! endothelial cell proliferation relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002044 name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002045 name: regulation of cell adhesion involved in intussusceptive angiogenesis namespace: biological_process def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0030155 ! regulation of cell adhesion relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002046 name: opsin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0002047 name: phenazine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph] subset: gosubset_prok synonym: "acridizine biosynthesis" RELATED [] synonym: "acridizine biosynthetic process" RELATED [] synonym: "azophenylene biosynthesis" RELATED [] synonym: "azophenylene biosynthetic process" RELATED [] synonym: "dibenzo-p-diazine biosynthesis" RELATED [] synonym: "dibenzo-p-diazine biosynthetic process" RELATED [] synonym: "dibenzopyrazine biosynthesis" RELATED [] synonym: "dibenzopyrazine biosynthetic process" RELATED [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0002048 name: pyoverdine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763] synonym: "pyoverdine metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0002049 name: pyoverdine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0019290 ! siderophore biosynthetic process [Term] id: GO:0002050 name: pyoverdine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0046215 ! siderophore catabolic process [Term] id: GO:0002051 name: osteoblast fate commitment namespace: biological_process def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation namespace: biological_process def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] synonym: "activation of neuroblast proliferation" NARROW [] synonym: "stimulation of neuroblast proliferation" NARROW [] synonym: "up regulation of neuroblast proliferation" EXACT [] synonym: "up-regulation of neuroblast proliferation" EXACT [] synonym: "upregulation of neuroblast proliferation" EXACT [] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation relationship: positively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation namespace: biological_process def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] synonym: "activation of mesenchymal cell proliferation" NARROW [] synonym: "stimulation of mesenchymal cell proliferation" NARROW [] synonym: "up regulation of mesenchymal cell proliferation" EXACT [] synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] synonym: "upregulation of mesenchymal cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0002054 name: nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0002055 name: adenine binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenine, a purine base." [GOC:hjd] synonym: "6-aminopurine binding" EXACT [] is_a: GO:0002060 ! purine base binding [Term] id: GO:0002056 name: cytosine binding namespace: molecular_function def: "Interactiing selectively with cytosine." [GOC:hjd] is_a: GO:0002061 ! pyrimidine base binding [Term] id: GO:0002057 name: guanine binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanine." [GOC:hjd] is_a: GO:0002060 ! purine base binding [Term] id: GO:0002058 name: uracil binding namespace: molecular_function def: "Interacting selectively and non-covalently with uracil." [GOC:hjd] is_a: GO:0002061 ! pyrimidine base binding [Term] id: GO:0002059 name: thymine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thymine." [GOC:hjd] is_a: GO:0002061 ! pyrimidine base binding [Term] id: GO:0002060 name: purine base binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine base, an organic nitrogenous base with a purine skeleton." [CHEBI:26386, GOC:hjd] synonym: "purine binding" RELATED [GOC:curators] synonym: "purine nucleobase binding" EXACT [CHEBI:26386] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002061 name: pyrimidine base binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine base, an organic nitrogenous base with a pyrimidine skeleton." [CHEBI:26432, GOC:hjd] synonym: "1,3-diazine binding" NARROW [] synonym: "pyrimidine base binding" EXACT [CHEBI:26432] synonym: "pyrimidine binding" RELATED [GOC:curators] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002062 name: chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0002063 name: chondrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0002062 ! chondrocyte differentiation [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002068 name: glandular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development relationship: part_of GO:0002067 ! glandular epithelial cell differentiation [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development [Term] id: GO:0002070 name: epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation relationship: part_of GO:0002064 ! epithelial cell development [Term] id: GO:0002071 name: glandular epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation relationship: part_of GO:0002068 ! glandular epithelial cell development [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development namespace: biological_process def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0002074 name: extraocular skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982] is_a: GO:0007519 ! skeletal muscle tissue development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002075 name: somitomeric trunk muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982] is_a: GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0002076 name: osteoblast development namespace: biological_process def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002077 name: acrosome matrix dispersal namespace: biological_process def: "The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg." [GOC:dph, PMID:3886029] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002078 name: membrane fusion involved in acrosome reaction namespace: biological_process def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029] synonym: "membrane fusion involved in the acrosomal reaction" EXACT [] is_a: GO:0006944 ! cellular membrane fusion is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002079 name: inner acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405] comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0044425 ! membrane part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002080 name: acrosomal membrane namespace: cellular_component def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0001669 ! acrosomal vesicle [Term] id: GO:0002081 name: outer acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405] comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0044425 ! membrane part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002082 name: regulation of oxidative phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy relationship: regulates GO:0006119 ! oxidative phosphorylation [Term] id: GO:0002083 name: 4-hydroxybenzoate decaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:RXN-9230] xref: EC:2.5.1.39 xref: MetaCyc:RXN-9230 is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0002084 name: protein depalmitoylation namespace: biological_process def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd] is_a: GO:0035601 ! protein deacylation is_a: GO:0042159 ! lipoprotein catabolic process [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation namespace: biological_process def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tairtb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048505 ! regulation of timing of cell differentiation relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation [Term] id: GO:0002086 name: diaphragm contraction namespace: biological_process def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206] is_a: GO:0003011 ! involuntary skeletal muscle contraction is_a: GO:0003016 ! respiratory system process [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by neurological system process namespace: biological_process def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! neurological system process [Term] id: GO:0002088 name: lens development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] synonym: "lens development" EXACT [] synonym: "lens development in camera-style eye" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] synonym: "lens morphogenesis" EXACT [] synonym: "lens morphogenesis in camera-style eye" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0002088 ! lens development in camera-type eye relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0002090 name: regulation of receptor internalization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048259 ! regulation of receptor-mediated endocytosis is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0031623 ! receptor internalization [Term] id: GO:0002091 name: negative regulation of receptor internalization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "down regulation of receptor internalization" EXACT [] synonym: "down-regulation of receptor internalization" EXACT [] synonym: "downregulation of receptor internalization" EXACT [] synonym: "inhibition of receptor internalization" NARROW [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis relationship: negatively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002092 name: positive regulation of receptor internalization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "activation of receptor internalization" NARROW [] synonym: "stimulation of receptor internalization" NARROW [] synonym: "up regulation of receptor internalization" EXACT [] synonym: "up-regulation of receptor internalization" EXACT [] synonym: "upregulation of receptor internalization" EXACT [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis relationship: positively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002093 name: auditory receptor cell morphogenesis namespace: biological_process def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb] synonym: "hair cell morphogenesis" BROAD [GO:dph] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0060117 ! auditory receptor cell development [Term] id: GO:0002094 name: polyprenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd] subset: gosubset_prok is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0002095 name: caveolar macromolecular signaling complex namespace: cellular_component def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270] synonym: "caveolar macromolecular signalling complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005901 ! caveola [Term] id: GO:0002096 name: polkadots namespace: cellular_component def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340] comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0002097 name: tRNA wobble base modification namespace: biological_process def: "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002098 name: tRNA wobble uridine modification namespace: biological_process def: "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002099 name: tRNA wobble guanine modification namespace: biological_process def: "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002100 name: tRNA wobble adenosine to inosine editing namespace: biological_process def: "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002101 name: tRNA wobble cytosine modification namespace: biological_process def: "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002102 name: podosome namespace: cellular_component def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. xref: Wikipedia:Podosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0002103 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0002104 name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002105 name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002106 name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002107 name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III namespace: biological_process def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357] is_a: GO:0000481 ! maturation of 5S rRNA is_a: GO:0031125 ! rRNA 3'-end processing [Term] id: GO:0002108 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0002109 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0002110 name: cotranscriptional mitochondrial rRNA nucleotide insertion namespace: biological_process def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA", PMID:8306965] is_a: GO:0000154 ! rRNA modification is_a: GO:0070705 ! RNA nucleotide insertion [Term] id: GO:0002111 name: BRCA2-BRAF35 complex namespace: cellular_component def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0002112 name: interleukin-33 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-33 receptor." [GOC:hjd] synonym: "IL-33" NARROW [GOC:mah] synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0002113 name: interleukin-33 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-33." [GOC:hjd] synonym: "IL-33 binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0002114 name: interleukin-33 receptor activity namespace: molecular_function def: "Combining with interleukin-33 to initiate a change in cell activity." [GOC:hjd] synonym: "IL-33 receptor activity" EXACT [GOC:mah] synonym: "IL-33R" EXACT [GOC:mah] is_a: GO:0002113 ! interleukin-33 binding is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0002115 name: store-operated calcium entry namespace: biological_process def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum. synonym: "calcium ion import" BROAD [] synonym: "capacitative calcium entry" EXACT [] synonym: "SOCE" EXACT [] synonym: "store-operated calcium import" EXACT [] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0002116 name: semaphorin receptor complex namespace: cellular_component def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544] synonym: "plexin-neurophilin complex" EXACT [] is_a: GO:0043235 ! receptor complex [Term] id: GO:0002117 name: amphibian larval development namespace: biological_process def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, GOC:go_curators, http://www.livingunderworld.org/biology/] is_a: GO:0002164 ! larval development [Term] id: GO:0002118 name: aggressive behavior namespace: biological_process def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] synonym: "aggression" EXACT [] xref: Wikipedia:Aggression is_a: GO:0051705 ! behavioral interaction between organisms [Term] id: GO:0002119 name: nematode larval development namespace: biological_process def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv] is_a: GO:0002164 ! larval development [Term] id: GO:0002120 name: predatory aggressive behavior namespace: biological_process def: "Aggressive behavior involving attack on prey by a predator." [GOC:hjd] synonym: "predatory aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002121 name: inter-male aggressive behavior namespace: biological_process def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] synonym: "inter-male aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002122 name: fear-induced aggressive behavior namespace: biological_process def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd] synonym: "fear-induced aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002123 name: irritable aggressive behavior namespace: biological_process def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd] synonym: "irritable aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002124 name: territorial aggressive behavior namespace: biological_process def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd] synonym: "territorial aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002125 name: maternal aggressive behavior namespace: biological_process def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd] comment: Paternal aggression also exists. Serves to protect the offspring from intruders. synonym: "maternal aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002126 name: instrumental aggressive behavior namespace: biological_process def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd] synonym: "instrumental aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002127 name: wobble base cytosine methylation namespace: biological_process def: "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X] synonym: "wobble position m5C biosynthesis" EXACT [] is_a: GO:0002101 ! tRNA wobble cytosine modification is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002128 name: tRNA nucleoside ribose methylation namespace: biological_process def: "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002129 name: wobble position guanine ribose methylation namespace: biological_process def: "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002130 name: wobble position ribose methylation namespace: biological_process def: "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002128 ! tRNA nucleoside ribose methylation [Term] id: GO:0002131 name: wobble position cytosine ribose methylation namespace: biological_process def: "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002132 name: wobble position uridine ribose methylation namespace: biological_process def: "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002133 name: polycystin complex namespace: cellular_component def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144] comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant). is_a: GO:0043234 ! protein complex [Term] id: GO:0002134 name: UTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary"] is_a: GO:0032557 ! pyrimidine ribonucleotide binding [Term] id: GO:0002135 name: CTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607 "The Anatomical Basis of Mouse Development"] is_a: GO:0032557 ! pyrimidine ribonucleotide binding [Term] id: GO:0002136 name: wobble base lysidine biosynthesis namespace: biological_process def: "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617] comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP. is_a: GO:0002101 ! tRNA wobble cytosine modification [Term] id: GO:0002137 name: nuclear cluster namespace: cellular_component def: "Discrete hetero-chromatin-containing foci in interphase nuclei, which comprise clusters of centromeric DNA (as defined by gamma-satellite sequences and the abundance of heterochromatin protein 1 (HP-1)." [PMID:9413993] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0031618 ! nuclear centromeric heterochromatin [Term] id: GO:0002138 name: retinoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd] synonym: "retinoic acid anabolic process" EXACT [] is_a: GO:0042573 ! retinoic acid metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0002139 name: stereocilia coupling link namespace: cellular_component def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142] is_a: GO:0044464 ! cell part [Term] id: GO:0002140 name: stereocilia tip link namespace: cellular_component def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787] is_a: GO:0002139 ! stereocilia coupling link [Term] id: GO:0002141 name: stereocilia ankle link namespace: cellular_component def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809] is_a: GO:0002139 ! stereocilia coupling link [Term] id: GO:0002142 name: stereocilia ankle link complex namespace: cellular_component def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part relationship: part_of GO:0002141 ! stereocilia ankle link [Term] id: GO:0002143 name: tRNA wobble position uridine thiolation namespace: biological_process def: "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210] comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA. synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah] synonym: "wobble position s2U biosynthesis" EXACT [] is_a: GO:0002098 ! tRNA wobble uridine modification is_a: GO:0034227 ! tRNA thio-modification [Term] id: GO:0002144 name: cytosolic tRNA wobble base thiouridylase complex namespace: cellular_component def: "A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes." [PMID:18391219] synonym: "Cut1-Cut2 complex" NARROW [] synonym: "tRNA thiouridylase" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0002145 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H+." [MetaCyc:RXN0-3543] synonym: "HMP-PP diphosphatase" EXACT [] synonym: "HMP-PP pyrophosphatase" EXACT [] xref: MetaCyc:RXN0-3543 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0002146 name: steroid hormone receptor import into nucleus namespace: biological_process def: "The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd] comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "steroid hormone receptor nuclear translocation" NARROW [GOC:mah] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0002147 name: glucocorticoid receptor import into nucleus namespace: biological_process def: "The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd] synonym: "glucocorticoid receptor nuclear translocation" NARROW [GOC:mah] is_a: GO:0002146 ! steroid hormone receptor import into nucleus relationship: part_of GO:0042921 ! glucocorticoid receptor signaling pathway [Term] id: GO:0002148 name: hypochlorous acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:176150, PMIG:10085024] synonym: "HClO metabolic process" EXACT [] synonym: "HOCl metabolic process" EXACT [] synonym: "hypochlorite metabolic process" RELATED [] synonym: "hypochlorous acid metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0002149 name: hypochlorous acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils. synonym: "HClO biosynthetic process" EXACT [] synonym: "HOCl biosynthetic process" EXACT [] synonym: "hypochlorite biosynthetic process" RELATED [] synonym: "hypochlorous acid biosynthesis" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0002150 name: hypochlorous acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add] synonym: "HClO catabolic process" EXACT [] synonym: "HOCl catabolic process" EXACT [] synonym: "hypochlorite catabolic process" RELATED [] synonym: "hypochlorous acid catabolism" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0002151 name: G-quadruplex RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720] comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure. synonym: "G quadruplex binding" EXACT [GOC:mah] synonym: "G quartet binding" BROAD [GOC:hjd] synonym: "G quartet RNA binding" EXACT [GOC:hjd] synonym: "G-quartet binding" BROAD [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0002152 name: bile acid conjugation namespace: biological_process def: "The process in which bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413] comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine). is_a: GO:0008206 ! bile acid metabolic process [Term] id: GO:0002153 name: steroid receptor RNA activator RNA binding namespace: molecular_function def: "Selectively interacting with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [PMID:10199399, PMID:15180993] comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken). synonym: "SRA binding" EXACT [] is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0002154 name: thyroid hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a thyroid hormone." [GOC:hjd] synonym: "thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0002155 name: regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0002154 ! thyroid hormone mediated signaling pathway [Term] id: GO:0002156 name: negative regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "negative regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway [Term] id: GO:0002157 name: positive regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "positive regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway [Term] id: GO:0002158 name: osteoclast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] is_a: GO:0070661 ! leukocyte proliferation [Term] id: GO:0002159 name: desmosome assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0007043 ! cell-cell junction assembly [Term] id: GO:0002160 name: desmosome maintenance namespace: biological_process def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0045217 ! cell-cell junction maintenance [Term] id: GO:0002161 name: aminoacyl-tRNA editing activity namespace: molecular_function def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] synonym: "amino acid proofreading activity" RELATED [] synonym: "aminoacyl-tRNA hydrolysis activity" RELATED [] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0002162 name: dystroglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd] is_a: GO:0001948 ! glycoprotein binding [Term] id: GO:0002163 name: alpha-dystroglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with alpha-dystroglycan. Alpha-dystroglycan is extracellular protein derived from cleavage of dystroglycan." [GOC:hjd] is_a: GO:0002162 ! dystroglycan binding [Term] id: GO:0002164 name: larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002165 name: instar larval or pupal development namespace: biological_process def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002166 name: beta-dystroglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-dystroglycan. Beta-dystroglycan is a transmembrane protein derived from cleavage of dystroglycan." [GOC:hjd] is_a: GO:0002162 ! dystroglycan binding [Term] id: GO:0002167 name: VRK3/VHR/ERK complex namespace: cellular_component def: "A ternary complex consisting of VRK3 , VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380] is_a: GO:0043234 ! protein complex [Term] id: GO:0002168 name: instar larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0002164 ! larval development is_a: GO:0002165 ! instar larval or pupal development [Term] id: GO:0002169 name: 3-methylcrotonyl-CoA carboxylase complex, mitochondrial namespace: cellular_component def: "A heterodimeric complex having 3-methylcrotonyl-CoA carboxylase activity. The alpha subunit has a covalently bound biotin essential for the ATP-dependent carboxylation. The beta subunit possess carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:hjd, PMID:15868465] is_a: GO:0043234 ! protein complex is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0002170 name: high affinity IgA receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region to initiate a change in cell activity." [GOC:hjd] is_a: GO:0019766 ! IgA receptor activity [Term] id: GO:0002171 name: low affinity IgA receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region to initiate a change in cell activity." [GOC:hjd] is_a: GO:0019766 ! IgA receptor activity [Term] id: GO:0002172 name: high affinity IgM receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region to initiate a change in cell activity." [GOC:hjd] is_a: GO:0001793 ! IgM receptor activity [Term] id: GO:0002173 name: low affinity IgM receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region to initiate a change in cell activity." [GOC:hjd] is_a: GO:0001793 ! IgM receptor activity [Term] id: GO:0002174 name: mammary stem cell proliferation namespace: biological_process def: "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ." [PMID:15987436] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0002175 name: protein localization to paranode region of axon namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon." [PMID:18803321] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0002176 name: male germ cell proliferation namespace: biological_process def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd] is_a: GO:0008283 ! cell proliferation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0002177 name: manchette namespace: cellular_component def: "A conical shaped array of microtubules that completely covers the nucleus of a spermatid, thought to be involved in sperm head elongation." [PMID:15018141] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0002178 name: palmitoyltransferase complex namespace: cellular_component def: "A protein complex with palmitoyltransferase activity." [GOC:hjd] is_a: GO:0043234 ! protein complex [Term] id: GO:0002179 name: homodimeric serine palmitoyltransferase complex namespace: cellular_component def: "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine." [GOC:hjd] comment: This complex occurs primarily in bacteria. is_a: GO:0002178 ! palmitoyltransferase complex [Term] id: GO:0002180 name: 5-lipoxygenase complex namespace: cellular_component def: "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity." [PMID:19075240] is_a: GO:0043234 ! protein complex is_a: GO:0044453 ! nuclear membrane part [Term] id: GO:0002181 name: cytoplasmic translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] is_a: GO:0006412 ! translation [Term] id: GO:0002182 name: cytoplasmic translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd] is_a: GO:0006414 ! translational elongation relationship: part_of GO:0002181 ! cytoplasmic translation [Term] id: GO:0002183 name: cytoplasmic translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. . This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] is_a: GO:0006413 ! translational initiation relationship: part_of GO:0002181 ! cytoplasmic translation [Term] id: GO:0002184 name: cytoplasmic translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd] is_a: GO:0006415 ! translational termination relationship: part_of GO:0002181 ! cytoplasmic translation [Term] id: GO:0002200 name: somatic diversification of immune receptors namespace: biological_process def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16102575, PMID:16166509] comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002201 name: somatic diversification of DSCAM-based immune receptors namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects." [GOC:add, PMID:16261174] comment: Note that this type of immune receptor may not be limited to insects. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002202 name: somatic diversification of variable lymphocyte receptors of jawless fish namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish." [GOC:add, PMID:16373579] comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762). is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002203 name: proteolysis by cytosolic proteases associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497). is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002204 name: somatic recombination of immunoglobulin genes involved in immune response namespace: biological_process def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic recombination of antibody genes during immune response" RELATED [] synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002205 name: somatic hypermutation of immunoglobulin genes involved in immune response namespace: biological_process def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11205333, PMID:14991701] synonym: "somatic hypermutation of antibody genes during immune response" RELATED [] synonym: "somatic hypermutation of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: part_of GO:0002344 ! B cell affinity maturation [Term] id: GO:0002206 name: gene conversion of immunoglobulin genes namespace: biological_process def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes" EXACT [] is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion is_a: GO:0016445 ! somatic diversification of immunoglobulins is_a: GO:0035822 ! gene conversion [Term] id: GO:0002207 name: gene conversion of immunoglobulin genes involved in immune response namespace: biological_process def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes during immune response" RELATED [] synonym: "gene conversion of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002206 ! gene conversion of immunoglobulin genes is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response [Term] id: GO:0002208 name: somatic diversification of immunoglobulins involved in immune response namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14991701] synonym: "somatic diversification of antibodies during immune response" RELATED [] synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph] is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002209 name: behavioral defense response namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural defense response" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0007610 ! behavior [Term] id: GO:0002210 name: behavioral response to wounding namespace: biological_process def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural response to wounding" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009611 ! response to wounding [Term] id: GO:0002211 name: behavioral defense response to insect namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "behavioural defense response to insect" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002213 ! defense response to insect [Term] id: GO:0002212 name: behavioral defense response to nematode namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883] synonym: "behavioural defense response to nematode" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002215 ! defense response to nematode [Term] id: GO:0002213 name: defense response to insect namespace: biological_process alt_id: GO:0002214 def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "physiological defense response to insect" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0009625 ! response to insect [Term] id: GO:0002215 name: defense response to nematode namespace: biological_process alt_id: GO:0002216 def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883] synonym: "physiological defense response to nematode" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0009624 ! response to nematode [Term] id: GO:0002218 name: activation of innate immune response namespace: biological_process alt_id: GO:0002219 def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:16177805] comment: This term was added by GO_REF:0000022. is_a: GO:0002253 ! activation of immune response is_a: GO:0045089 ! positive regulation of innate immune response [Term] id: GO:0002220 name: innate immune response activating cell surface receptor signaling pathway namespace: biological_process def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT [] synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002221 name: pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] synonym: "PRR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002222 name: stimulatory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002223 name: stimulatory C-type lectin receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT [] synonym: "stimulatory Ly49 family receptor signaling pathway." NARROW [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002224 name: toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses. synonym: "TLR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology"] synonym: "toll-like receptor signalling pathway" EXACT [] xref: Reactome:1253149 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1280083 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1298965 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1326654 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1352766 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1372977 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1392993 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1417473 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1450566 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1471073 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1483089 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1496964 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1514351 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1521223 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1526812 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:1532538 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:168188 "Toll Like Receptor TLR6:TLR2 Cascade" xref: Reactome:437987 "Innate immune response mediated by toll like receptors" is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002225 name: positive regulation of antimicrobial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545] synonym: "activation of antimicrobial peptide production" NARROW [] synonym: "antimicrobial peptide induction" EXACT [] synonym: "stimulation of antimicrobial peptide production" NARROW [] synonym: "up regulation of antimicrobial peptide production" EXACT [] synonym: "up-regulation of antimicrobial peptide production" EXACT [] synonym: "upregulation of antimicrobial peptide production" EXACT [] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002784 ! regulation of antimicrobial peptide production relationship: positively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002227 name: innate immune response in mucosa namespace: biological_process def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105] is_a: GO:0002385 ! mucosal immune response is_a: GO:0045087 ! innate immune response [Term] id: GO:0002228 name: natural killer cell mediated immunity namespace: biological_process def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "NK cell mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0045087 ! innate immune response [Term] id: GO:0002229 name: defense response to oomycetes namespace: biological_process def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589] is_a: GO:0002239 ! response to oomycetes is_a: GO:0006952 ! defense response [Term] id: GO:0002230 name: positive regulation of defense response to virus by host namespace: biological_process def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of antiviral response by host" NARROW [] synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of antiviral response by host" NARROW [] synonym: "up regulation of antiviral response by host" EXACT [] synonym: "up-regulation of antiviral response by host" EXACT [] synonym: "upregulation of antiviral response by host" EXACT [] is_a: GO:0050691 ! regulation of defense response to virus by host [Term] id: GO:0002231 name: detection of oomycetes namespace: biological_process def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649] is_a: GO:0002239 ! response to oomycetes is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune cell chemotaxis during inflammatory response" RELATED [] synonym: "leucocyte chemotaxis during inflammatory response" RELATED [] synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph] is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune cell chemotaxis during immune response" EXACT [] synonym: "leucocyte chemotaxis during immune response" EXACT [] is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002234 name: detection of endoplasmic reticulum overloading namespace: biological_process def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516] synonym: "detection of ER overloading" EXACT [] is_a: GO:0006983 ! ER overload response is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002235 name: detection of unfolded protein namespace: biological_process def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470] is_a: GO:0006986 ! response to unfolded protein is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002236 name: detection of misfolded protein namespace: biological_process def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0051788 ! response to misfolded protein [Term] id: GO:0002237 name: response to molecule of bacterial origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm] synonym: "response to bacteria associated molecule" EXACT [] synonym: "response to bacterial associated molecule" EXACT [] synonym: "response to bacterium associated molecule" EXACT [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0010033 ! response to organic substance relationship: part_of GO:0009617 ! response to bacterium [Term] id: GO:0002238 name: response to molecule of fungal origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm] synonym: "response to fungus associated molecule" EXACT [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0010033 ! response to organic substance relationship: part_of GO:0009620 ! response to fungus [Term] id: GO:0002239 name: response to oomycetes namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589] is_a: GO:0051707 ! response to other organism [Term] id: GO:0002240 name: response to molecule of oomycetes origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm] synonym: "response to oomycetes associated molecule" EXACT [] is_a: GO:0009607 ! response to biotic stimulus relationship: part_of GO:0002239 ! response to oomycetes [Term] id: GO:0002241 name: response to parasitic plant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862] is_a: GO:0009608 ! response to symbiont [Term] id: GO:0002242 name: defense response to parasitic plant namespace: biological_process def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0006952 ! defense response [Term] id: GO:0002243 name: detection of parasitic plant namespace: biological_process def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0009602 ! detection of symbiont [Term] id: GO:0002244 name: hemopoietic progenitor cell differentiation namespace: biological_process def: "The process in which precursor cell type acquires the specialized features of a hemopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16551251] synonym: "haematopoietic progenitor cell differentiation" EXACT [] synonym: "haemopoietic progenitor cell differentiation" EXACT [] synonym: "hematopoietic progenitor cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002246 name: wound healing involved in inflammatory response namespace: biological_process def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "healing during inflammatory response" RELATED [GOC:dph] synonym: "inflammatory response wound healing" RELATED [GOC:dph] is_a: GO:0042060 ! wound healing relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002247 name: clearance of damaged tissue involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "clearance of damaged tissue during inflammatory response" RELATED [GOC:dph] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002248 name: connective tissue replacement involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "connective tissue replacement during inflammatory response" RELATED [GOC:dph] synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002249 name: lymphocyte anergy namespace: biological_process def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002250 name: adaptive immune response namespace: biological_process def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "acquired immune response" EXACT [ISBN:068340007X "Stedman's Medical Dictionary"] xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response [Term] id: GO:0002251 name: organ or tissue specific immune response namespace: biological_process def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "immune response in organ or tissue" EXACT [] is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that can potentially contribute to an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process [Term] id: GO:0002253 name: activation of immune response namespace: biological_process def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0002254 name: kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002526 ! acute inflammatory response is_a: GO:0072376 ! protein activation cascade [Term] id: GO:0002255 name: tissue kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145] synonym: "glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002256 name: regulation of kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:2000257 ! regulation of protein activation cascade relationship: regulates GO:0002254 ! kinin cascade [Term] id: GO:0002257 name: negative regulation of kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "down regulation of kinin cascade" EXACT [] synonym: "down-regulation of kinin cascade" EXACT [] synonym: "downregulation of kinin cascade" EXACT [] synonym: "inhibition of kinin cascade" NARROW [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:2000258 ! negative regulation of protein activation cascade relationship: negatively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002258 name: positive regulation of kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "activation of kinin cascade" NARROW [] synonym: "stimulation of kinin cascade" NARROW [] synonym: "up regulation of kinin cascade" EXACT [] synonym: "up-regulation of kinin cascade" EXACT [] synonym: "upregulation of kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:2000259 ! positive regulation of protein activation cascade relationship: positively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002259 name: endothelial cell activation within high endothelial venule involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "endothelial cell activation within high endothelial venule during immune response" RELATED [GOC:tb] is_a: GO:0002264 ! endothelial cell activation involved in immune response [Term] id: GO:0002260 name: lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] is_a: GO:0001776 ! leukocyte homeostasis [Term] id: GO:0002261 name: mucosal lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0002263 name: cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002264 name: endothelial cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "endothelial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0042118 ! endothelial cell activation [Term] id: GO:0002265 name: astrocyte activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785] synonym: "astrocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0048143 ! astrocyte activation [Term] id: GO:0002266 name: follicular dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789] is_a: GO:0001775 ! cell activation [Term] id: GO:0002267 name: follicular dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789] synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0002266 ! follicular dendritic cell activation [Term] id: GO:0002268 name: follicular dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002266 ! follicular dendritic cell activation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response namespace: biological_process def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune cell activation during inflammatory response" RELATED [] synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb] is_a: GO:0045321 ! leukocyte activation relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002270 name: plasmacytoid dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002271 name: plasmacytoid dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109] synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002272 name: plasmacytoid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333] synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph] is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation [Term] id: GO:0002273 name: plasmacytoid dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0002521 ! leukocyte differentiation [Term] id: GO:0002274 name: myeloid leukocyte activation namespace: biological_process def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "myeloid leucocyte activation" EXACT [] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002275 name: myeloid cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "myeloid cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002276 name: basophil activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "basophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045575 ! basophil activation [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response [Term] id: GO:0002278 name: eosinophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "eosinophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0043307 ! eosinophil activation [Term] id: GO:0002279 name: mast cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045576 ! mast cell activation [Term] id: GO:0002280 name: monocyte activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16551245] synonym: "monocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042117 ! monocyte activation [Term] id: GO:0002281 name: macrophage activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "macrophage activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042116 ! macrophage activation [Term] id: GO:0002282 name: microglial cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "microglial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001774 ! microglial cell activation is_a: GO:0002281 ! macrophage activation involved in immune response [Term] id: GO:0002283 name: neutrophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "neutrophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042119 ! neutrophil activation [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb] is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation [Term] id: GO:0002285 name: lymphocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "lymphocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0002286 name: T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T cell activation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte activation during immune response" RELATED [] synonym: "T-cell activation during immune response" RELATED [] synonym: "T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation [Term] id: GO:0002287 name: alpha-beta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte activation during immune response" RELATED [] synonym: "alpha-beta T-cell activation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0002288 name: NK T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte activation during immune response" RELATED [] synonym: "natural killer T-cell activation during immune response" RELATED [] synonym: "natural killer T-lymphocyte activation during immune response" RELATED [] synonym: "NK T cell activation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte activation during immune response" RELATED [] synonym: "NK T-cell activation during immune response" RELATED [] synonym: "NK T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0051132 ! NK T cell activation [Term] id: GO:0002289 name: NK T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte proliferation during immune response" RELATED [] synonym: "natural killer T-cell proliferation during immune response" RELATED [] synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED [] synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte proliferation during immune response" RELATED [] synonym: "NK T-cell proliferation during immune response" RELATED [] synonym: "NK T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0001866 ! NK T cell proliferation is_a: GO:0002288 ! NK T cell activation involved in immune response is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response [Term] id: GO:0002290 name: gamma-delta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523] synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte activation during immune response" RELATED [] synonym: "gamma-delta T-cell activation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0002291 name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] is_a: GO:0002286 ! T cell activation involved in immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development involved in immune response" RELATED [GOC:add] synonym: "T cell differentiation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte differentiation during immune response" RELATED [] synonym: "T-cell differentiation during immune response" RELATED [] synonym: "T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0002293 name: alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002294 name: CD4-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0002295 name: T-helper cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T-helper cell fate commitment" EXACT [] synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149 "Fundamental Immunology"] synonym: "Thp lineage commitment" RELATED [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0042093 ! T-helper cell differentiation [Term] id: GO:0002296 name: T-helper 1 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] synonym: "Th1 fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0002297 name: T-helper 2 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] synonym: "Th2 fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0002298 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0002299 name: alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002300 name: CD8-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0002301 name: CD4-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0002302 name: CD8-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0002303 name: gamma-delta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta T cell development involved in immune response" RELATED [GOC:add] synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph] synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED [] synonym: "gamma-delta T-cell differentiation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002304 name: gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002305 name: CD8-positive, gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002306 name: CD4-positive gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002307 name: CD8-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002308 name: CD8-positive, alpha-beta cytotoxic T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta cytotoxic T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0002309 name: T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T cell proliferation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte proliferation during immune response" RELATED [] synonym: "T-cell proliferation during immune response" RELATED [] synonym: "T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0042098 ! T cell proliferation [Term] id: GO:0002310 name: alpha-beta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED [] synonym: "alpha-beta T-cell proliferation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0002311 name: gamma-delta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add] synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED [] synonym: "gamma-delta T-cell proliferation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0002312 name: B cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] synonym: "B cell activation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte activation during immune response" RELATED [] synonym: "B-cell activation during immune response" RELATED [] synonym: "B-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042113 ! B cell activation [Term] id: GO:0002313 name: mature B cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B cell development involved in immune response" RELATED [GOC:add] synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb] synonym: "mature B lymphocyte differentiation during immune response" RELATED [] synonym: "mature B-cell differentiation during immune response" RELATED [] synonym: "mature B-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0002314 name: germinal center B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "germinal center B cell development" RELATED [GOC:add] synonym: "germinal center B lymphocyte differentiation" EXACT [] synonym: "germinal center B-cell differentiation" EXACT [] synonym: "germinal center B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002315 name: marginal zone B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "marginal zone B cell development" RELATED [GOC:add] synonym: "marginal zone B lymphocyte differentiation" EXACT [] synonym: "marginal zone B-cell differentiation" EXACT [] synonym: "marginal zone B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002316 name: follicular B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "follicular B cell development" RELATED [GOC:add] synonym: "follicular B lymphocyte differentiation" EXACT [] synonym: "follicular B-cell differentiation" EXACT [] synonym: "follicular B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002317 name: plasma cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "plasma cell development" RELATED [GOC:add] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002318 name: myeloid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hemopoietic progenitor cell differentiation [Term] id: GO:0002319 name: memory B cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "memory B cell development" RELATED [GOC:add] synonym: "memory B lymphocyte differentiation" EXACT [] synonym: "memory B-cell differentiation" EXACT [] synonym: "memory B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002320 name: lymphoid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002244 ! hemopoietic progenitor cell differentiation [Term] id: GO:0002321 name: natural killer cell progenitor differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002322 name: B cell proliferation involved in immune response namespace: biological_process def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal] synonym: "B cell proliferation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte proliferation during immune response" RELATED [] synonym: "B-cell proliferation during immune response" RELATED [] synonym: "B-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002323 name: natural killer cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell activation during immune response" RELATED [GOC:tb] synonym: "NK cell activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0030101 ! natural killer cell activation [Term] id: GO:0002324 name: natural killer cell proliferation involved in immune response namespace: biological_process def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK cell proliferation during immune response" RELATED [] is_a: GO:0001787 ! natural killer cell proliferation is_a: GO:0002323 ! natural killer cell activation involved in immune response [Term] id: GO:0002325 name: natural killer cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "NK cell differentiation during immune response" RELATED [] is_a: GO:0001779 ! natural killer cell differentiation is_a: GO:0002323 ! natural killer cell activation involved in immune response [Term] id: GO:0002326 name: B cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte lineage commitment" EXACT [] synonym: "B-cell lineage commitment" EXACT [] synonym: "B-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002327 name: immature B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551251] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "immature B cell development" RELATED [GOC:add] synonym: "immature B lymphocyte differentiation" EXACT [] synonym: "immature B-cell differentiation" EXACT [] synonym: "immature B-lymphocyte differentiation" EXACT [] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002328 name: pro-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "pro-B cell development" RELATED [GOC:add] synonym: "pro-B lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002329 name: pre-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "pre-B cell development" RELATED [GOC:add] synonym: "pre-B lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002330 name: pre-B cell receptor expression namespace: biological_process def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002331 name: pre-B cell allelic exclusion namespace: biological_process def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "pre-B lymphocyte allelic exclusion" EXACT [] is_a: GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002332 name: transitional stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "transitional stage B cell development" RELATED [GOC:add] synonym: "transitional stage B lymphocyte differentiation" EXACT [] synonym: "transitional stage B-cell differentiation" EXACT [] synonym: "transitional stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002333 name: transitional one stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T1 stage B cell differentiation" EXACT [] synonym: "transitional one stage B cell development" RELATED [GOC:add] synonym: "transitional one stage B lymphocyte differentiation" EXACT [] synonym: "transitional one stage B-cell differentiation" EXACT [] synonym: "transitional one stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002334 name: transitional two stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T2 stage B cell differentiation" EXACT [] synonym: "transitional two stage B cell development" RELATED [GOC:add] synonym: "transitional two stage B lymphocyte differentiation" EXACT [] synonym: "transitional two stage B-cell differentiation" EXACT [] synonym: "transitional two stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002335 name: mature B cell differentiation namespace: biological_process def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B lymphocyte differentiation" EXACT [] synonym: "mature B-cell differentiation" EXACT [] synonym: "mature B-lymphocyte differentiation" EXACT [] synonym: "mature cell development" RELATED [GOC:add] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002336 name: B-1 B cell lineage commitment namespace: biological_process def: "The process in which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B-1 B lymphocyte lineage commitment" EXACT [] synonym: "B-1 B-cell lineage commitment" EXACT [] synonym: "B-1 B-lymphocyte lineage commitment" EXACT [] is_a: GO:0002326 ! B cell lineage commitment relationship: part_of GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002337 name: B-1a B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1a B cell development" RELATED [GOC:add] synonym: "B-1a B lymphocyte differentiation" EXACT [] synonym: "B-1a B-cell differentiation" EXACT [] synonym: "B-1a B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002338 name: B-1b B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1b B cell development" RELATED [GOC:add] synonym: "B-1b B lymphocyte differentiation" EXACT [] synonym: "B-1b B-cell differentiation" EXACT [] synonym: "B-1b B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002339 name: B cell selection namespace: biological_process def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal] synonym: "B lymphocyte selection" EXACT [] synonym: "B-cell selection" EXACT [] synonym: "B-lymphocyte selection" EXACT [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002340 name: central B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal] synonym: "central B lymphocyte selection" EXACT [] synonym: "central B-cell selection" EXACT [] synonym: "central B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002341 name: central B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte anergy" EXACT [] synonym: "central B-cell anergy" EXACT [] synonym: "central B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002342 name: central B cell deletion namespace: biological_process def: "The deletion of B cells by apoptosis occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal] synonym: "central B lymphocyte deletion" EXACT [] synonym: "central B-cell deletion" EXACT [] synonym: "central B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002343 name: peripheral B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte selection" EXACT [] synonym: "peripheral B-cell selection" EXACT [] synonym: "peripheral B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002344 name: B cell affinity maturation namespace: biological_process def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "B lymphocyte affinity maturation" EXACT [] synonym: "B-cell affinity maturation" EXACT [] synonym: "B-lymphocyte affinity maturation" EXACT [] is_a: GO:0002343 ! peripheral B cell selection relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002345 name: peripheral B cell receptor editing namespace: biological_process def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal] synonym: "peripheral B lymphocyte receptor editing" EXACT [] synonym: "peripheral B-cell receptor editing" EXACT [] synonym: "peripheral B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002346 name: B cell positive selection namespace: biological_process def: "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal] synonym: "B lymphocyte positive selection" EXACT [] synonym: "B-cell positive selection" EXACT [] synonym: "B-lymphocyte positive selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002347 name: response to tumor cell namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0002348 name: central B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "central B lymphocyte positive selection" EXACT [] synonym: "central B-cell positive selection" EXACT [] synonym: "central B-lymphocyte positive selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002349 name: histamine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] synonym: "histamine production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002350 name: peripheral B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "peripheral B lymphocyte positive selection" EXACT [] synonym: "peripheral B-cell positive selection" EXACT [] synonym: "peripheral B-lymphocyte positive selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002351 name: serotonin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] synonym: "serotonin production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002352 name: B cell negative selection namespace: biological_process def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal] synonym: "B lymphocyte negative selection" EXACT [] synonym: "B-cell negative selection" EXACT [] synonym: "B-lymphocyte negative selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002353 name: plasma kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002354 name: central B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte negative selection" EXACT [] synonym: "central B-cell negative selection" EXACT [] synonym: "central B-lymphocyte negative selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002355 name: detection of tumor cell namespace: biological_process def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002356 name: peripheral B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte negative selection" EXACT [] synonym: "peripheral B-cell negative selection" EXACT [] synonym: "peripheral B-lymphocyte negative selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002357 name: defense response to tumor cell namespace: biological_process def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006952 ! defense response [Term] id: GO:0002358 name: B cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal] synonym: "B lymphocyte homeostatic proliferation" EXACT [] synonym: "B-cell homeostatic proliferation" EXACT [] synonym: "B-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002359 name: B-1 B cell proliferation namespace: biological_process def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal] synonym: "B-1 B lymphocyte proliferation" EXACT [] synonym: "B-1 B-cell proliferation" EXACT [] synonym: "B-1 B-lymphocyte proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002360 name: T cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte lineage commitment" EXACT [] synonym: "T-cell lineage commitment" EXACT [] synonym: "T-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002361 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002362 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0002363 name: alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "alpha-beta T-cell lineage commitment" EXACT [] synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002364 name: NK T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "natural killer T lymphocyte lineage commitment" EXACT [] synonym: "natural killer T-cell lineage commitment" EXACT [] synonym: "natural killer T-lymphocyte lineage commitment" EXACT [] synonym: "NK T lymphocyte lineage commitment" EXACT [] synonym: "NK T-cell lineage commitment" EXACT [] synonym: "NK T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0001865 ! NK T cell differentiation [Term] id: GO:0002365 name: gamma-delta T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "gamma-delta T lymphocyte lineage commitment" EXACT [] synonym: "gamma-delta T-cell lineage commitment" EXACT [] synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002366 name: leukocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune cell activation during immune response" RELATED [] synonym: "leucocyte activation during immune response" RELATED [] synonym: "leukocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002367 name: cytokine production involved in immune response namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. synonym: "cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002368 name: B cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte cytokine production" EXACT [] synonym: "B-cell cytokine production" EXACT [] synonym: "B-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002369 name: T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte cytokine production" EXACT [] synonym: "T-cell cytokine production" EXACT [] synonym: "T-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002370 name: natural killer cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "NK cell cytokine production" EXACT [] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002371 name: dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002372 name: myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002371 ! dendritic cell cytokine production is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0002373 name: plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002374 name: cytokine secretion involved in immune response namespace: biological_process def: "The regulated release of cytokines from a cell or group of cells that contributes to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002375 name: cytokine biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022. subset: goslim_generic subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process [Term] id: GO:0002377 name: immunoglobulin production namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antibody production" EXACT [] is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002378 name: immunoglobulin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antibody biosynthesis" EXACT [] synonym: "antibody biosynthetic process" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0002379 name: immunoglobulin biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antibody biosynthesis during immune response" RELATED [] synonym: "antibody biosynthetic process during immune response" RELATED [] synonym: "immunoglobulin biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002378 ! immunoglobulin biosynthetic process relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002380 name: immunoglobulin secretion involved in immune response namespace: biological_process def: "The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:9185563] synonym: "antibody secretion during immune response" RELATED [] synonym: "immunoglobulin secretion during immune response" RELATED [goc:dph] is_a: GO:0048305 ! immunoglobulin secretion relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002381 name: immunoglobulin production involved in immunoglobulin mediated immune response namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antibody production during immune response" RELATED [] synonym: "immunoglobulin production during immune response" RELATED [GOC:dph] synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph] is_a: GO:0002377 ! immunoglobulin production relationship: part_of GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002382 name: regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002383 name: immune response in brain or nervous system namespace: biological_process def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002384 name: hepatic immune response namespace: biological_process def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002385 name: mucosal immune response namespace: biological_process def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002386 name: immune response in mucosal-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune response in MALT" EXACT [] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002387 name: immune response in gut-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune response in GALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002388 name: immune response in Peyer's patch namespace: biological_process def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue [Term] id: GO:0002389 name: tolerance induction in Peyer's patch namespace: biological_process def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002388 ! immune response in Peyer's patch is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue [Term] id: GO:0002390 name: platelet activating factor production namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001816 ! cytokine production [Term] id: GO:0002391 name: platelet activating factor production involved in inflammatory response namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "platelet activating factor production involved in acute inflammatory response" BROAD [] is_a: GO:0002390 ! platelet activating factor production is_a: GO:0002534 ! cytokine production involved in inflammatory response [Term] id: GO:0002392 name: platelet activating factor secretion namespace: biological_process def: "The regulated release of platelet activating factor by a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0050663 ! cytokine secretion [Term] id: GO:0002393 name: lysosomal enzyme production involved in inflammatory response namespace: biological_process def: "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add] synonym: "lysosomal enzyme production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of lysosomal enzymes involved in acute inflammatory response" BROAD [] synonym: "production of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002394 name: tolerance induction in gut-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "oral tolerance" RELATED [] synonym: "tolerance induction in GALT" EXACT [] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue [Term] id: GO:0002395 name: immune response in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune response in NALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002396 name: MHC protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0002397 name: MHC class I protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002398 name: MHC class Ib protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002399 name: MHC class II protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002400 name: tolerance induction in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "nasal tolerance" RELATED [] synonym: "tolerance induction in NALT" EXACT [] is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue [Term] id: GO:0002401 name: tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "tolerance induction in MALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002402 name: B cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002403 name: T cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551263] synonym: "T cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002404 name: antigen sampling in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746] synonym: "antigen sampling in MALT" EXACT [] synonym: "antigen transport in MALT" RELATED [] synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002405 name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746] synonym: "antigen sampling by dendritic cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002406 name: antigen sampling by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763] synonym: "antigen sampling by M cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue [Term] id: GO:0002407 name: dendritic cell chemotaxis namespace: biological_process def: "The movement of a dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15814331, PMID:16056255] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002408 name: myeloid dendritic cell chemotaxis namespace: biological_process def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15814331, PMID:16056255] is_a: GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:0002409 name: Langerhans cell chemotaxis namespace: biological_process def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601] is_a: GO:0002408 ! myeloid dendritic cell chemotaxis [Term] id: GO:0002410 name: plasmacytoid dendritic cell chemotaxis namespace: biological_process def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331] is_a: GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:0002411 name: T cell tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002413 ! tolerance induction to tumor cell is_a: GO:0002424 ! T cell mediated immune response to tumor cell is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002412 name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:12843411] synonym: "antigen transcytosis by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT [] is_a: GO:0045056 ! transcytosis relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue [Term] id: GO:0002413 name: tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add] is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002414 name: immunoglobulin transcytosis in epithelial cells namespace: biological_process def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X, PMID:16048543] is_a: GO:0045056 ! transcytosis [Term] id: GO:0002415 name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor namespace: biological_process def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X, PMID:16048543] synonym: "antibody transcytosis mediated by pIgR" EXACT [] synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002416 name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor namespace: biological_process def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X] synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT [] synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells [Term] id: GO:0002417 name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis [Term] id: GO:0002418 name: immune response to tumor cell namespace: biological_process def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006955 ! immune response [Term] id: GO:0002419 name: T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001913 ! T cell mediated cytotoxicity is_a: GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002420 name: natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell is_a: GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0002421 name: B cell antigen processing and presentation following pinocytosis namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530] synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002422 name: immune response in urogenital tract namespace: biological_process def: "An immune response taking place in the urogenital tract. The urogenital tract." [GOC:jal] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002423 name: natural killer cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002418 ! immune response to tumor cell [Term] id: GO:0002424 name: T cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells. is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002425 name: tolerance induction in urogenital tract namespace: biological_process def: "Tolerance induction taking place in the urogenital tract." [GOC:jal] is_a: GO:0002422 ! immune response in urogenital tract is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002426 name: immunoglobulin production in mucosal tissue namespace: biological_process def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal] synonym: "antibody production in mucosal tissue " EXACT [] is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response relationship: part_of GO:0002385 ! mucosal immune response [Term] id: GO:0002427 name: mucosal tolerance induction namespace: biological_process def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal] is_a: GO:0002385 ! mucosal immune response is_a: GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002428 name: antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678] synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002429 name: immune response-activating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT [] synonym: "immune response-activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002757 ! immune response-activating signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002430 name: complement receptor mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "complement receptor mediated signalling pathway" EXACT [] synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002431 name: Fc receptor mediated stimulatory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT [] synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002432 name: granuloma formation namespace: biological_process def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0721601464, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process relationship: part_of GO:0002544 ! chronic inflammatory response [Term] id: GO:0002433 name: phagocytosis triggered by activation of immune response cell surface activating receptor namespace: biological_process def: "Phagocytosis occurring as the result of a ligand binding an immune response cell surface activating receptor." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process is_a: GO:0006909 ! phagocytosis [Term] id: GO:0002434 name: immune complex clearance namespace: biological_process def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X "Stedman's Medical Dictionary"] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process [Term] id: GO:0002435 name: immune complex clearance by erythrocytes namespace: biological_process def: "The process of immune complex clearance by erythrocytes." [GOC:add, PMID:11414352] synonym: "immune complex clearance by RBCs" EXACT [CL:0000232] synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002436 name: immune complex clearance by monocytes and macrophages namespace: biological_process def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002437 name: inflammatory response to antigenic stimulus namespace: biological_process def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0006954 ! inflammatory response is_a: GO:0006955 ! immune response [Term] id: GO:0002438 name: acute inflammatory response to antigenic stimulus namespace: biological_process def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002439 name: chronic inflammatory response to antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002440 name: production of molecular mediator of immune response namespace: biological_process def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "production of cellular mediator of immune response" RELATED [] is_a: GO:0002376 ! immune system process [Term] id: GO:0002441 name: histamine secretion involved in inflammatory response namespace: biological_process def: "The regulated release of histamine by a cell or group of cells as part of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "histamine secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001821 ! histamine secretion is_a: GO:0046879 ! hormone secretion relationship: part_of GO:0002349 ! histamine production involved in inflammatory response [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response namespace: biological_process def: "The regulated release of serotonin by a cell or group of cells as part of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "serotonin secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001820 ! serotonin secretion relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process alt_id: GO:0019723 alt_id: GO:0042087 def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002445 name: type II hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: Wikipedia:Type_II_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002446 name: neutrophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002447 name: eosinophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002448 name: mast cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002449 name: lymphocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002450 name: B cell antigen processing and presentation namespace: biological_process def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "B lymphocyte antigen processing and presentation" EXACT [] synonym: "B-cell antigen processing and presentation" EXACT [] synonym: "B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0019724 ! B cell mediated immunity [Term] id: GO:0002451 name: peripheral B cell tolerance induction namespace: biological_process def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "peripheral B lymphocyte tolerance induction" EXACT [] synonym: "peripheral B-cell tolerance induction" EXACT [] synonym: "peripheral B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002514 ! B cell tolerance induction is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002452 name: B cell receptor editing namespace: biological_process def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte receptor editing" EXACT [] synonym: "B-cell receptor editing" EXACT [] synonym: "B-lymphocyte receptor editing" EXACT [] is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002453 name: peripheral B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "peripheral B lymphocyte anergy" EXACT [] synonym: "peripheral B-cell anergy" EXACT [] synonym: "peripheral B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002454 name: peripheral B cell deletion namespace: biological_process def: "The deletion of B cells by apoptosis occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "peripheral B lymphocyte deletion" EXACT [] synonym: "peripheral B-cell deletion" EXACT [] synonym: "peripheral B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002455 name: humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "circulating antibody mediated immune response" EXACT [] synonym: "circulating immunoglobulin mediated immune response" EXACT [] synonym: "humoral defence mechanism" RELATED [] synonym: "humoral immune response mediated by circulating antibody" EXACT [] is_a: GO:0006959 ! humoral immune response is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002456 name: T cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] synonym: "T lymphocyte mediated immunity" EXACT [] synonym: "T-cell mediated immunity" EXACT [] synonym: "T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002457 name: T cell antigen processing and presentation namespace: biological_process def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] synonym: "T lymphocyte antigen processing and presentation" EXACT [] synonym: "T-cell antigen processing and presentation" EXACT [] synonym: "T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0002456 ! T cell mediated immunity [Term] id: GO:0002458 name: peripheral T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "peripheral T lymphocyte tolerance induction" EXACT [] synonym: "peripheral T-cell tolerance induction" EXACT [] synonym: "peripheral T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002459 name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains namespace: biological_process def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579] synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT [] synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT [] synonym: "adaptive immune response in jawless fish" EXACT [] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002461 name: tolerance induction dependent upon immune response namespace: biological_process def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "immune response-dependent tolerance induction" EXACT [] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002462 name: tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002463 name: central tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002508 ! central tolerance induction [Term] id: GO:0002464 name: peripheral tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002465 name: peripheral tolerance induction namespace: biological_process def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002466 name: peripheral tolerance induction to self antigen namespace: biological_process def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002467 name: germinal center formation namespace: biological_process def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002469 name: myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002470 name: plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002471 name: monocyte antigen processing and presentation namespace: biological_process def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002472 name: macrophage antigen processing and presentation namespace: biological_process def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002473 name: non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002474 name: antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002475 name: antigen processing and presentation via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002476 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen [Term] id: GO:0002477 name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen [Term] id: GO:0002478 name: antigen processing and presentation of exogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "exogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002479 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002480 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002481 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002482 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002483 name: antigen processing and presentation of endogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "endogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002484 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002485 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002486 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002487 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943] synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002488 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib [Term] id: GO:0002489 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002490 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002491 name: antigen processing and presentation of endogenous peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338] synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002492 name: peptide antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002493 name: lipid antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0065005 ! protein-lipid complex assembly relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002494 name: lipid antigen transport namespace: biological_process def: "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0006869 ! lipid transport relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002495 name: antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15531770, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002496 name: proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002497 name: proteasomal proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0002498 name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT [] synonym: "ER proteolysis associated with antigen processing and presentation" EXACT [] synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002499 name: proteolysis within endosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002500 name: proteolysis within lysosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation is_a: GO:0007039 ! vacuolar protein catabolic process [Term] id: GO:0002501 name: peptide antigen assembly with MHC protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0002396 ! MHC protein complex assembly relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002502 name: peptide antigen assembly with MHC class I protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002397 ! MHC class I protein complex assembly relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002503 name: peptide antigen assembly with MHC class II protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002399 ! MHC class II protein complex assembly relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15531770, PMID:15771591, PMID:16153240] synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002505 name: antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240] synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002506 name: polysaccharide assembly with MHC class II protein complex namespace: biological_process def: "The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex." [GOC:add, PMID:16153240] is_a: GO:0065006 ! protein-carbohydrate complex assembly relationship: part_of GO:0002399 ! MHC class II protein complex assembly relationship: part_of GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002507 name: tolerance induction namespace: biological_process def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002508 name: central tolerance induction namespace: biological_process def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002509 name: central tolerance induction to self antigen namespace: biological_process def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16460922] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002510 name: central B cell tolerance induction namespace: biological_process def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte tolerance induction" EXACT [] synonym: "central B-cell tolerance induction" EXACT [] synonym: "central B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002511 name: central B cell receptor editing namespace: biological_process def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte receptor editing" EXACT [] synonym: "central B-cell receptor editing" EXACT [] synonym: "central B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002512 name: central T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "central T lymphocyte tolerance induction" EXACT [] synonym: "central T-cell tolerance induction" EXACT [] synonym: "central T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002513 name: tolerance induction to self antigen namespace: biological_process def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002514 name: B cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16460922] synonym: "B lymphocyte tolerance induction" EXACT [] synonym: "B-cell tolerance induction" EXACT [] synonym: "B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002515 name: B cell anergy namespace: biological_process def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte anergy" EXACT [] synonym: "B-cell anergy" EXACT [] synonym: "B-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002516 name: B cell deletion namespace: biological_process def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte deletion" EXACT [] synonym: "B-cell deletion" EXACT [] synonym: "B-lymphocyte deletion" EXACT [] is_a: GO:0001783 ! B cell apoptosis relationship: part_of GO:0002514 ! B cell tolerance induction [Term] id: GO:0002517 name: T cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551263] synonym: "T lymphocyte tolerance induction" EXACT [] synonym: "T-cell tolerance induction" EXACT [] synonym: "T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002518 name: lymphocyte chemotaxis across high endothelial venule namespace: biological_process def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15122201] is_a: GO:0048247 ! lymphocyte chemotaxis [Term] id: GO:0002519 name: natural killer cell tolerance induction namespace: biological_process def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094] synonym: "NK cell tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development [Term] id: GO:0002521 name: leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] synonym: "immune cell differentiation" EXACT [] synonym: "leucocyte differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002522 name: leukocyte migration involved in immune response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during immune response" EXACT [] synonym: "immune cell trafficking during immune response" EXACT [] synonym: "leucocyte migration during immune response" EXACT [] synonym: "leucocyte trafficking during immune response" EXACT [] synonym: "leukocyte trafficking during immune response" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during inflammatory response" RELATED [] synonym: "immune cell trafficking during inflammatory response" RELATED [] synonym: "leucocyte migration during inflammatory response" RELATED [] synonym: "leucocyte trafficking during inflammatory response" RELATED [] synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph] synonym: "leukocyte trafficking during inflammatory response" RELATED [] is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002524 name: hypersensitivity namespace: biological_process def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "hypersensitivity response" RELATED [ISBN:0781735149 "Fundamental Immunology"] xref: Wikipedia:Hypersensitivity is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002525 name: acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326] is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002526 name: acute inflammatory response namespace: biological_process def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002527 name: vasodilation involved in acute inflammatory response namespace: biological_process def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal] synonym: "vasodilation during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0042311 ! vasodilation relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002528 name: regulation of vascular permeability involved in acute inflammatory response namespace: biological_process def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal] synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0043114 ! regulation of vascular permeability relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002529 name: regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] is_a: GO:0002256 ! regulation of kinin cascade relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002530 name: regulation of systemic arterial blood pressure involved in acute-phase response namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X] synonym: "blood pressure regulation during acute phase response" RELATED [] synonym: "regulation of systemic arterial blood pressure during acute phase response" RELATED [GOC:tb] is_a: GO:0003073 ! regulation of systemic arterial blood pressure relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002531 name: regulation of heart contraction involved in acute-phase response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430] synonym: "regulation of cardiac contraction during acute phase response" RELATED [] synonym: "regulation of heart contraction during acute phase response" RELATED [GOC:tb] is_a: GO:0008016 ! regulation of heart contraction relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response namespace: biological_process def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149 "Fundamental Immunology"] synonym: "production of cellular mediator of acute inflammation" RELATED [] synonym: "production of molecular mediator involved in acute inflammatory response" BROAD [] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002533 name: lysosomal enzyme secretion involved in inflammatory response namespace: biological_process def: "The regulated release of lysosomal enzymes by a cell or group of cells as part of an inflammatory response." [GOC:jal, PMID:11836514] synonym: "lysosomal enzyme secretion involved in acute inflammatory response" RELATED [GOC:mah] synonym: "secretion of lysosomal enzymes involved in acute inflammatory response" BROAD [] synonym: "secretion of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0033299 ! secretion of lysosomal enzymes relationship: part_of GO:0002393 ! lysosomal enzyme production involved in inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "cytokine production involved in acute inflammatory response" BROAD [] is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002535 name: platelet activating factor secretion involved in inflammatory response namespace: biological_process def: "The regulated release of platelet activating factor by a cell or group of cells as part of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "platelet activating factor secretion involved in acute inflammatory response" BROAD [] is_a: GO:0002392 ! platelet activating factor secretion relationship: part_of GO:0002391 ! platelet activating factor production involved in inflammatory response [Term] id: GO:0002536 name: respiratory burst involved in inflammatory response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "oxidative burst during acute inflammatory response " BROAD [] synonym: "production of reactive oxygen species during acute inflammatory response" BROAD [] synonym: "respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response is_a: GO:0002679 ! respiratory burst involved in defense response [Term] id: GO:0002537 name: nitric oxide production involved in inflammatory response namespace: biological_process def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "nitric oxide production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of nitric oxide involved in acute inflammatory response" BROAD [] synonym: "production of nitric oxide involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002538 name: arachidonic acid metabolite production involved in inflammatory response namespace: biological_process def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD [] synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002539 name: prostaglandin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "prostaglandin production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002540 name: leukotriene production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "leukotriene production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002541 name: activation of plasma proteins involved in acute inflammatory response namespace: biological_process def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0051605 ! protein maturation by peptide bond cleavage relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002542 name: Factor XII activation namespace: biological_process def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871] synonym: "Hageman factor activation" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0010954 ! positive regulation of protein maturation by peptide bond cleavage relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response [Term] id: GO:0002543 name: activation of blood coagulation via clotting cascade namespace: biological_process def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of clotting cascade" EXACT [] is_a: GO:0030194 ! positive regulation of blood coagulation relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002544 name: chronic inflammatory response namespace: biological_process def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002545 name: chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal] is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002546 name: negative regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW [] synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002547 name: positive regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "activation of tissue kallikrein-kinin cascade" NARROW [] synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT [] synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW [] synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002548 name: monocyte chemotaxis namespace: biological_process def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002549 name: negative regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002550 name: positive regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "activation of plasma kallikrein-kinin cascade" NARROW [] synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW [] synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002551 name: mast cell chemotaxis namespace: biological_process def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002552 name: serotonin secretion by mast cell namespace: biological_process def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002553 name: histamine secretion by mast cell namespace: biological_process def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002554 name: serotonin secretion by platelet namespace: biological_process def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002555 name: histamine secretion by platelet namespace: biological_process def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517] is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002556 name: serotonin secretion by basophil namespace: biological_process def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002557 name: histamine secretion by basophil namespace: biological_process def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002558 name: type I hypersensitivity mediated by mast cells namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002448 ! mast cell mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002559 name: type I hypersensitivity mediated by basophils namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002560 ! basophil mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002560 name: basophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002561 name: basophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002276 ! basophil activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002560 ! basophil mediated immunity [Term] id: GO:0002562 name: somatic diversification of immune receptors via germline recombination within a single locus namespace: biological_process def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16102575, PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002563 name: somatic diversification of immune receptors via alternate splicing namespace: biological_process def: "The process in which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002564 name: alternate splicing of immunoglobulin genes namespace: biological_process def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149 "Fundamental Immunology", PMID:9185563] synonym: "alternate splicing of antibody genes" EXACT [] is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0002565 name: somatic diversification of immune receptors via gene conversion namespace: biological_process def: "The process in which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002566 name: somatic diversification of immune receptors via somatic mutation namespace: biological_process def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149 "Fundamental Immunology", PMID:16102575] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002567 name: somatic diversification of FREP-based immune receptors namespace: biological_process def: "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails." [GOC:add, PMID:16102575] comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002568 name: somatic diversification of T cell receptor genes namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of T cell receptor genes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic diversification of TCR genes" EXACT [] is_a: GO:0002200 ! somatic diversification of immune receptors relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002569 name: somatic diversification of immune receptors by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002570 name: somatic diversification of immunoglobulin genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic diversification of antibody genes by N region addition" EXACT [] is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002571 name: somatic diversification of T cell receptor genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic diversification of TCR genes by N region addition" EXACT [] is_a: GO:0002568 ! somatic diversification of T cell receptor genes is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments [Term] id: GO:0002572 name: pro-T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "pro-T lymphocyte differentiation " EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002573 name: myeloid leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] synonym: "myeloid leucocyte differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002574 name: thrombocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add] comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220. is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002575 name: basophil chemotaxis namespace: biological_process def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002576 name: platelet degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add] synonym: "platelet exocytosis" EXACT [] xref: Reactome:114608 "Platelet degranulation" xref: Reactome:1253600 "Platelet degranulation" xref: Reactome:1280531 "Platelet degranulation" xref: Reactome:1299361 "Platelet degranulation" xref: Reactome:1327117 "Platelet degranulation" xref: Reactome:1353212 "Platelet degranulation" xref: Reactome:1373391 "Platelet degranulation" xref: Reactome:1393414 "Platelet degranulation" xref: Reactome:1417908 "Platelet degranulation" xref: Reactome:1450998 "Platelet degranulation" xref: Reactome:1471380 "Platelet degranulation" xref: Reactome:1483336 "Platelet degranulation" xref: Reactome:1497021 "Platelet degranulation" xref: Reactome:1514408 "Platelet degranulation" xref: Reactome:1521276 "Platelet degranulation" xref: Reactome:1526982 "Platelet degranulation" xref: Reactome:1532718 "Platelet degranulation" xref: Reactome:1536117 "Platelet degranulation" xref: Reactome:1538077 "Platelet degranulation" is_a: GO:0006887 ! exocytosis [Term] id: GO:0002577 name: regulation of antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process relationship: regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002578 name: negative regulation of antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "down regulation of antigen processing and presentation" EXACT [] synonym: "down-regulation of antigen processing and presentation" EXACT [] synonym: "downregulation of antigen processing and presentation" EXACT [] synonym: "inhibition of antigen processing and presentation" NARROW [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002683 ! negative regulation of immune system process relationship: negatively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002579 name: positive regulation of antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "activation of antigen processing and presentation" NARROW [] synonym: "stimulation of antigen processing and presentation" NARROW [] synonym: "up regulation of antigen processing and presentation" EXACT [] synonym: "up-regulation of antigen processing and presentation" EXACT [] synonym: "upregulation of antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002684 ! positive regulation of immune system process relationship: positively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002580 name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002581 name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002582 name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002583 name: regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002584 name: negative regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002585 name: positive regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002586 name: regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002587 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002588 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002589 name: regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002590 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002591 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002592 name: regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002593 name: negative regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002594 name: positive regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002595 name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002596 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002597 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002598 name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002599 name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002600 name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002601 name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002602 name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002603 name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002604 name: regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002605 name: negative regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002606 name: positive regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002607 name: regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002608 name: negative regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002609 name: positive regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002610 name: regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002611 name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002612 name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002613 name: regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002614 name: negative regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "down regulation of monocyte antigen processing and presentation" EXACT [] synonym: "down-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "downregulation of monocyte antigen processing and presentation" EXACT [] synonym: "inhibition of monocyte antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002615 name: positive regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "activation of monocyte antigen processing and presentation" NARROW [] synonym: "stimulation of monocyte antigen processing and presentation" NARROW [] synonym: "up regulation of monocyte antigen processing and presentation" EXACT [] synonym: "up-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "upregulation of monocyte antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002616 name: regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002617 name: negative regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "down regulation of macrophage antigen processing and presentation" EXACT [] synonym: "down-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "downregulation of macrophage antigen processing and presentation" EXACT [] synonym: "inhibition of macrophage antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002618 name: positive regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "activation of macrophage antigen processing and presentation" NARROW [] synonym: "stimulation of macrophage antigen processing and presentation" NARROW [] synonym: "up regulation of macrophage antigen processing and presentation" EXACT [] synonym: "up-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "upregulation of macrophage antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002619 name: regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002620 name: negative regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002621 name: positive regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002622 name: regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of B-cell antigen processing and presentation" EXACT [] synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002712 ! regulation of B cell mediated immunity relationship: regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002623 name: negative regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "down regulation of B cell antigen processing and presentation" EXACT [] synonym: "down-regulation of B cell antigen processing and presentation" EXACT [] synonym: "downregulation of B cell antigen processing and presentation" EXACT [] synonym: "inhibition of B cell antigen processing and presentation" NARROW [] synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of B-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002624 name: positive regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "activation of B cell antigen processing and presentation" NARROW [] synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of B-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of B cell antigen processing and presentation" NARROW [] synonym: "up regulation of B cell antigen processing and presentation" EXACT [] synonym: "up-regulation of B cell antigen processing and presentation" EXACT [] synonym: "upregulation of B cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002625 name: regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of T-cell antigen processing and presentation" EXACT [] synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002709 ! regulation of T cell mediated immunity relationship: regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002626 name: negative regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "down regulation of T cell antigen processing and presentation" EXACT [] synonym: "down-regulation of T cell antigen processing and presentation" EXACT [] synonym: "downregulation of T cell antigen processing and presentation" EXACT [] synonym: "inhibition of T cell antigen processing and presentation" NARROW [] synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of T-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002627 name: positive regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "activation of T cell antigen processing and presentation" NARROW [] synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of T-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of T cell antigen processing and presentation" NARROW [] synonym: "up regulation of T cell antigen processing and presentation" EXACT [] synonym: "up-regulation of T cell antigen processing and presentation" EXACT [] synonym: "upregulation of T cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002628 name: regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002629 name: negative regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW [] is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:0045861 ! negative regulation of proteolysis relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002630 name: positive regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:0045862 ! positive regulation of proteolysis relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002631 name: regulation of granuloma formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002432 ! granuloma formation [Term] id: GO:0002632 name: negative regulation of granuloma formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "down regulation of granuloma formation" EXACT [] synonym: "down-regulation of granuloma formation" EXACT [] synonym: "downregulation of granuloma formation" EXACT [] synonym: "inhibition of granuloma formation" NARROW [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002698 ! negative regulation of immune effector process relationship: negatively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002633 name: positive regulation of granuloma formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "activation of granuloma formation" NARROW [] synonym: "stimulation of granuloma formation" NARROW [] synonym: "up regulation of granuloma formation" EXACT [] synonym: "up-regulation of granuloma formation" EXACT [] synonym: "upregulation of granuloma formation" EXACT [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002699 ! positive regulation of immune effector process relationship: positively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002634 name: regulation of germinal center formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002467 ! germinal center formation [Term] id: GO:0002635 name: negative regulation of germinal center formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "down regulation of germinal center formation" EXACT [] synonym: "down-regulation of germinal center formation" EXACT [] synonym: "downregulation of germinal center formation" EXACT [] synonym: "inhibition of germinal center formation" NARROW [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002636 name: positive regulation of germinal center formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "activation of germinal center formation" NARROW [] synonym: "stimulation of germinal center formation" NARROW [] synonym: "up regulation of germinal center formation" EXACT [] synonym: "up-regulation of germinal center formation" EXACT [] synonym: "upregulation of germinal center formation" EXACT [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002637 name: regulation of immunoglobulin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002638 name: negative regulation of immunoglobulin production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "down regulation of immunoglobulin production" EXACT [] synonym: "down-regulation of immunoglobulin production" EXACT [] synonym: "downregulation of immunoglobulin production" EXACT [] synonym: "inhibition of immunoglobulin production" NARROW [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response relationship: negatively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002639 name: positive regulation of immunoglobulin production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "activation of immunoglobulin production" NARROW [] synonym: "stimulation of immunoglobulin production" NARROW [] synonym: "up regulation of immunoglobulin production" EXACT [] synonym: "up-regulation of immunoglobulin production" EXACT [] synonym: "upregulation of immunoglobulin production" EXACT [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response relationship: positively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002640 name: regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0010556 ! regulation of macromolecule biosynthetic process relationship: regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002641 name: negative regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "down regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "down-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "downregulation of immunoglobulin biosynthetic process" EXACT [] synonym: "inhibition of immunoglobulin biosynthetic process" NARROW [] is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process relationship: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002642 name: positive regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "activation of immunoglobulin biosynthetic process" NARROW [] synonym: "stimulation of immunoglobulin biosynthetic process" NARROW [] synonym: "up regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "up-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "upregulation of immunoglobulin biosynthetic process" EXACT [] is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process relationship: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002643 name: regulation of tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0002507 ! tolerance induction [Term] id: GO:0002644 name: negative regulation of tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "down regulation of tolerance induction" EXACT [] synonym: "down-regulation of tolerance induction" EXACT [] synonym: "downregulation of tolerance induction" EXACT [] synonym: "inhibition of tolerance induction" NARROW [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002683 ! negative regulation of immune system process relationship: negatively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002645 name: positive regulation of tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "activation of tolerance induction" NARROW [] synonym: "stimulation of tolerance induction" NARROW [] synonym: "up regulation of tolerance induction" EXACT [] synonym: "up-regulation of tolerance induction" EXACT [] synonym: "upregulation of tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002684 ! positive regulation of immune system process relationship: positively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002646 name: regulation of central tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002647 name: negative regulation of central tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "down regulation of central tolerance induction" EXACT [] synonym: "down-regulation of central tolerance induction" EXACT [] synonym: "downregulation of central tolerance induction" EXACT [] synonym: "inhibition of central tolerance induction" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction relationship: negatively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002648 name: positive regulation of central tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "activation of central tolerance induction" NARROW [] synonym: "stimulation of central tolerance induction" NARROW [] synonym: "up regulation of central tolerance induction" EXACT [] synonym: "up-regulation of central tolerance induction" EXACT [] synonym: "upregulation of central tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction relationship: positively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002649 name: regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002650 name: negative regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "down regulation of tolerance induction to self antigen" EXACT [] synonym: "down-regulation of tolerance induction to self antigen" EXACT [] synonym: "downregulation of tolerance induction to self antigen" EXACT [] synonym: "inhibition of tolerance induction to self antigen" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002651 name: positive regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "activation of tolerance induction to self antigen" NARROW [] synonym: "stimulation of tolerance induction to self antigen" NARROW [] synonym: "up regulation of tolerance induction to self antigen" EXACT [] synonym: "up-regulation of tolerance induction to self antigen" EXACT [] synonym: "upregulation of tolerance induction to self antigen" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002652 name: regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002653 name: negative regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "down regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "downregulation of tolerance induction dependent upon immune response" EXACT [] synonym: "inhibition of tolerance induction dependent upon immune response" NARROW [] synonym: "negative regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002654 name: positive regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "activation of tolerance induction dependent upon immune response" NARROW [] synonym: "positive regulation of immune response-dependent tolerance induction" EXACT [] synonym: "stimulation of tolerance induction dependent upon immune response" NARROW [] synonym: "up regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "upregulation of tolerance induction dependent upon immune response" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002655 name: regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response relationship: regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002656 name: negative regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "down regulation of tolerance induction to nonself antigen" EXACT [] synonym: "down-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "downregulation of tolerance induction to nonself antigen" EXACT [] synonym: "inhibition of tolerance induction to nonself antigen" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002657 name: positive regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "activation of tolerance induction to nonself antigen" NARROW [] synonym: "stimulation of tolerance induction to nonself antigen" NARROW [] synonym: "up regulation of tolerance induction to nonself antigen" EXACT [] synonym: "up-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "upregulation of tolerance induction to nonself antigen" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002658 name: regulation of peripheral tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response relationship: regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002659 name: negative regulation of peripheral tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "down regulation of peripheral tolerance induction" EXACT [] synonym: "down-regulation of peripheral tolerance induction" EXACT [] synonym: "downregulation of peripheral tolerance induction" EXACT [] synonym: "inhibition of peripheral tolerance induction" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002660 name: positive regulation of peripheral tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "activation of peripheral tolerance induction" NARROW [] synonym: "stimulation of peripheral tolerance induction" NARROW [] synonym: "up regulation of peripheral tolerance induction" EXACT [] synonym: "up-regulation of peripheral tolerance induction" EXACT [] synonym: "upregulation of peripheral tolerance induction" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction relationship: positively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002661 name: regulation of B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "regulation of B lymphocyte tolerance induction" EXACT [] synonym: "regulation of B-cell tolerance induction" EXACT [] synonym: "regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002662 name: negative regulation of B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "down regulation of B cell tolerance induction" EXACT [] synonym: "down-regulation of B cell tolerance induction" EXACT [] synonym: "downregulation of B cell tolerance induction" EXACT [] synonym: "inhibition of B cell tolerance induction" NARROW [] synonym: "negative regulation of B lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of B-cell tolerance induction" EXACT [] synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction relationship: negatively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002663 name: positive regulation of B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "activation of B cell tolerance induction" NARROW [] synonym: "positive regulation of B lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of B-cell tolerance induction" EXACT [] synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of B cell tolerance induction" NARROW [] synonym: "up regulation of B cell tolerance induction" EXACT [] synonym: "up-regulation of B cell tolerance induction" EXACT [] synonym: "upregulation of B cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction relationship: positively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002664 name: regulation of T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "regulation of T lymphocyte tolerance induction" EXACT [] synonym: "regulation of T-cell tolerance induction" EXACT [] synonym: "regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002665 name: negative regulation of T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "down regulation of T cell tolerance induction" EXACT [] synonym: "down-regulation of T cell tolerance induction" EXACT [] synonym: "downregulation of T cell tolerance induction" EXACT [] synonym: "inhibition of T cell tolerance induction" NARROW [] synonym: "negative regulation of T lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of T-cell tolerance induction" EXACT [] synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction relationship: negatively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002666 name: positive regulation of T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "activation of T cell tolerance induction" NARROW [] synonym: "positive regulation of T lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of T-cell tolerance induction" EXACT [] synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of T cell tolerance induction" NARROW [] synonym: "up regulation of T cell tolerance induction" EXACT [] synonym: "up-regulation of T cell tolerance induction" EXACT [] synonym: "upregulation of T cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction relationship: positively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002667 name: regulation of T cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "regulation of T lymphocyte anergy" EXACT [] synonym: "regulation of T-cell anergy" EXACT [] synonym: "regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: regulates GO:0002870 ! T cell anergy [Term] id: GO:0002668 name: negative regulation of T cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "down regulation of T cell anergy" EXACT [] synonym: "down-regulation of T cell anergy" EXACT [] synonym: "downregulation of T cell anergy" EXACT [] synonym: "inhibition of T cell anergy" NARROW [] synonym: "negative regulation of T lymphocyte anergy" EXACT [] synonym: "negative regulation of T-cell anergy" EXACT [] synonym: "negative regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy relationship: negatively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002669 name: positive regulation of T cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "activation of T cell anergy" NARROW [] synonym: "positive regulation of T lymphocyte anergy" EXACT [] synonym: "positive regulation of T-cell anergy" EXACT [] synonym: "positive regulation of T-lymphocyte anergy" EXACT [] synonym: "stimulation of T cell anergy" NARROW [] synonym: "up regulation of T cell anergy" EXACT [] synonym: "up-regulation of T cell anergy" EXACT [] synonym: "upregulation of T cell anergy" EXACT [] is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy relationship: positively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002670 name: regulation of B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "regulation of B lymphocyte anergy" EXACT [] synonym: "regulation of B-cell anergy" EXACT [] synonym: "regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: regulates GO:0002515 ! B cell anergy [Term] id: GO:0002671 name: negative regulation of B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "down regulation of B cell anergy" EXACT [] synonym: "down-regulation of B cell anergy" EXACT [] synonym: "downregulation of B cell anergy" EXACT [] synonym: "inhibition of B cell anergy" NARROW [] synonym: "negative regulation of B lymphocyte anergy" EXACT [] synonym: "negative regulation of B-cell anergy" EXACT [] synonym: "negative regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy relationship: negatively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002672 name: positive regulation of B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "activation of B cell anergy" NARROW [] synonym: "positive regulation of B lymphocyte anergy" EXACT [] synonym: "positive regulation of B-cell anergy" EXACT [] synonym: "positive regulation of B-lymphocyte anergy" EXACT [] synonym: "stimulation of B cell anergy" NARROW [] synonym: "up regulation of B cell anergy" EXACT [] synonym: "up-regulation of B cell anergy" EXACT [] synonym: "upregulation of B cell anergy" EXACT [] is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy relationship: positively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002673 name: regulation of acute inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response relationship: regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002674 name: negative regulation of acute inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "down regulation of acute inflammatory response" EXACT [] synonym: "down-regulation of acute inflammatory response" EXACT [] synonym: "downregulation of acute inflammatory response" EXACT [] synonym: "inhibition of acute inflammatory response" NARROW [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response relationship: negatively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002675 name: positive regulation of acute inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "activation of acute inflammatory response" NARROW [] synonym: "stimulation of acute inflammatory response" NARROW [] synonym: "up regulation of acute inflammatory response" EXACT [] synonym: "up-regulation of acute inflammatory response" EXACT [] synonym: "upregulation of acute inflammatory response" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response relationship: positively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002676 name: regulation of chronic inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response relationship: regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002677 name: negative regulation of chronic inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "down regulation of chronic inflammatory response" EXACT [] synonym: "down-regulation of chronic inflammatory response" EXACT [] synonym: "downregulation of chronic inflammatory response" EXACT [] synonym: "inhibition of chronic inflammatory response" NARROW [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response relationship: negatively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002678 name: positive regulation of chronic inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "activation of chronic inflammatory response" NARROW [] synonym: "stimulation of chronic inflammatory response" NARROW [] synonym: "up regulation of chronic inflammatory response" EXACT [] synonym: "up-regulation of chronic inflammatory response" EXACT [] synonym: "upregulation of chronic inflammatory response" EXACT [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response relationship: positively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002679 name: respiratory burst involved in defense response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12789499] is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst relationship: part_of GO:0006952 ! defense response [Term] id: GO:0002680 name: pro-T cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "pro-T cell fate commitment" EXACT [] synonym: "pro-T lymphocyte fate commitment" EXACT [] synonym: "pro-T lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0002572 ! pro-T cell differentiation [Term] id: GO:0002681 name: somatic recombination of T cell receptor gene segments namespace: biological_process def: "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic recombination of TCR gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0002568 ! somatic diversification of T cell receptor genes [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0002376 ! immune system process [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0002376 ! immune system process [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0002376 ! immune system process [Term] id: GO:0002685 name: regulation of leukocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "regulation of immune cell migration" EXACT [] synonym: "regulation of leucocyte migration" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002686 name: negative regulation of leukocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "down regulation of leukocyte migration" EXACT [] synonym: "down-regulation of leukocyte migration" EXACT [] synonym: "downregulation of leukocyte migration" EXACT [] synonym: "inhibition of leukocyte migration" NARROW [] synonym: "negative regulation of immune cell migration" EXACT [] synonym: "negative regulation of leucocyte migration" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030336 ! negative regulation of cell migration relationship: negatively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "activation of leukocyte migration" NARROW [] synonym: "positive regulation of immune cell migration" EXACT [] synonym: "positive regulation of leucocyte migration" EXACT [] synonym: "stimulation of leukocyte migration" NARROW [] synonym: "up regulation of leukocyte migration" EXACT [] synonym: "up-regulation of leukocyte migration" EXACT [] synonym: "upregulation of leukocyte migration" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration relationship: positively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "regulation of immune cell chemotaxis" EXACT [] synonym: "regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis relationship: regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002689 name: negative regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "down regulation of leukocyte chemotaxis" EXACT [] synonym: "down-regulation of leukocyte chemotaxis" EXACT [] synonym: "downregulation of leukocyte chemotaxis" EXACT [] synonym: "inhibition of leukocyte chemotaxis" NARROW [] synonym: "negative regulation of immune cell chemotaxis" EXACT [] synonym: "negative regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050922 ! negative regulation of chemotaxis relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "activation of leukocyte chemotaxis" NARROW [] synonym: "positive regulation of immune cell chemotaxis" EXACT [] synonym: "positive regulation of leucocyte chemotaxis" EXACT [] synonym: "stimulation of leukocyte chemotaxis" NARROW [] synonym: "up regulation of leukocyte chemotaxis" EXACT [] synonym: "up-regulation of leukocyte chemotaxis" EXACT [] synonym: "upregulation of leukocyte chemotaxis" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002691 name: regulation of cellular extravasation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add] is_a: GO:0002685 ! regulation of leukocyte migration relationship: regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002692 name: negative regulation of cellular extravasation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "down regulation of cellular extravasation" EXACT [] synonym: "down-regulation of cellular extravasation" EXACT [] synonym: "downregulation of cellular extravasation" EXACT [] synonym: "inhibition of cellular extravasation" NARROW [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation relationship: negatively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002693 name: positive regulation of cellular extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "activation of cellular extravasation" NARROW [] synonym: "stimulation of cellular extravasation" NARROW [] synonym: "up regulation of cellular extravasation" EXACT [] synonym: "up-regulation of cellular extravasation" EXACT [] synonym: "upregulation of cellular extravasation" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation relationship: positively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002694 name: regulation of leukocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "regulation of immune cell activation" EXACT [] synonym: "regulation of leucocyte activation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation relationship: regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "down regulation of leukocyte activation" EXACT [] synonym: "down-regulation of leukocyte activation" EXACT [] synonym: "downregulation of leukocyte activation" EXACT [] synonym: "inhibition of leukocyte activation" NARROW [] synonym: "negative regulation of immune cell activation" EXACT [] synonym: "negative regulation of leucocyte activation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation relationship: negatively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "activation of leukocyte activation" NARROW [] synonym: "positive regulation of immune cell activation" EXACT [] synonym: "positive regulation of leucocyte activation" EXACT [] synonym: "stimulation of leukocyte activation" NARROW [] synonym: "up regulation of leukocyte activation" EXACT [] synonym: "up-regulation of leukocyte activation" EXACT [] synonym: "upregulation of leukocyte activation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation relationship: positively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process relationship: regulates GO:0002252 ! immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process relationship: negatively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process relationship: positively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "down regulation of production of molecular mediator of immune response" EXACT [] synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] synonym: "downregulation of production of molecular mediator of immune response" EXACT [] synonym: "inhibition of production of molecular mediator of immune response" NARROW [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "activation of production of molecular mediator of immune response" NARROW [] synonym: "stimulation of production of molecular mediator of immune response" NARROW [] synonym: "up regulation of production of molecular mediator of immune response" EXACT [] synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] synonym: "upregulation of production of molecular mediator of immune response" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "down regulation of lymphocyte mediated immunity" EXACT [] synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] synonym: "downregulation of lymphocyte mediated immunity" EXACT [] synonym: "inhibition of lymphocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "activation of lymphocyte mediated immunity" NARROW [] synonym: "stimulation of lymphocyte mediated immunity" NARROW [] synonym: "up regulation of lymphocyte mediated immunity" EXACT [] synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] synonym: "upregulation of lymphocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002709 name: regulation of T cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "regulation of T lymphocyte mediated immunity" EXACT [] synonym: "regulation of T-cell mediated immunity" EXACT [] synonym: "regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002710 name: negative regulation of T cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "down regulation of T cell mediated immunity" EXACT [] synonym: "down-regulation of T cell mediated immunity" EXACT [] synonym: "downregulation of T cell mediated immunity" EXACT [] synonym: "inhibition of T cell mediated immunity" NARROW [] synonym: "negative regulation of T lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of T-cell mediated immunity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002711 name: positive regulation of T cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "activation of T cell mediated immunity" NARROW [] synonym: "positive regulation of T lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of T-cell mediated immunity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of T cell mediated immunity" NARROW [] synonym: "up regulation of T cell mediated immunity" EXACT [] synonym: "up-regulation of T cell mediated immunity" EXACT [] synonym: "upregulation of T cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002712 name: regulation of B cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "regulation of B lymphocyte mediated immunity" EXACT [] synonym: "regulation of B-cell mediated immunity" EXACT [] synonym: "regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002713 name: negative regulation of B cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "down regulation of B cell mediated immunity" EXACT [] synonym: "down-regulation of B cell mediated immunity" EXACT [] synonym: "downregulation of B cell mediated immunity" EXACT [] synonym: "inhibition of B cell mediated immunity" NARROW [] synonym: "negative regulation of B lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of B-cell mediated immunity" EXACT [] synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002714 name: positive regulation of B cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "activation of B cell mediated immunity" NARROW [] synonym: "positive regulation of B lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of B-cell mediated immunity" EXACT [] synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of B cell mediated immunity" NARROW [] synonym: "up regulation of B cell mediated immunity" EXACT [] synonym: "up-regulation of B cell mediated immunity" EXACT [] synonym: "upregulation of B cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002715 name: regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045845 def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "regulation of natural killer cell activity" RELATED [] synonym: "regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002716 name: negative regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0030102 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "down regulation of natural killer cell mediated immunity" EXACT [] synonym: "down-regulation of natural killer cell mediated immunity" EXACT [] synonym: "downregulation of natural killer cell mediated immunity" EXACT [] synonym: "inhibition of natural killer cell mediated immunity" NARROW [] synonym: "negative regulation of natural killer cell activity" RELATED [] synonym: "negative regulation of NK cell activity" RELATED [] synonym: "negative regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045824 ! negative regulation of innate immune response relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002717 name: positive regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045846 def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "activation of natural killer cell mediated immunity" NARROW [] synonym: "positive regulation of natural killer cell activity" RELATED [] synonym: "positive regulation of NK cell activity" RELATED [] synonym: "positive regulation of NK cell mediated immunity" EXACT [] synonym: "stimulation of natural killer cell mediated immunity" NARROW [] synonym: "up regulation of natural killer cell mediated immunity" EXACT [] synonym: "up-regulation of natural killer cell mediated immunity" EXACT [] synonym: "upregulation of natural killer cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045089 ! positive regulation of innate immune response relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine production during immune response" RELATED [] synonym: "down-regulation of cytokine production during immune response" EXACT [] synonym: "downregulation of cytokine production during immune response" RELATED [] synonym: "inhibition of cytokine production during immune response" RELATED [] synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "activation of cytokine production during immune response" NARROW [] synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine production during immune response" NARROW [] synonym: "up regulation of cytokine production during immune response" RELATED [] synonym: "up-regulation of cytokine production during immune response" RELATED [] synonym: "upregulation of cytokine production during immune response" RELATED [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002721 name: regulation of B cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "regulation of B lymphocyte cytokine production" EXACT [] synonym: "regulation of B-cell cytokine production" EXACT [] synonym: "regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002722 name: negative regulation of B cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "down regulation of B cell cytokine production" EXACT [] synonym: "down-regulation of B cell cytokine production" EXACT [] synonym: "downregulation of B cell cytokine production" EXACT [] synonym: "inhibition of B cell cytokine production" NARROW [] synonym: "negative regulation of B lymphocyte cytokine production" EXACT [] synonym: "negative regulation of B-cell cytokine production" EXACT [] synonym: "negative regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production relationship: negatively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002723 name: positive regulation of B cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "activation of B cell cytokine production" NARROW [] synonym: "positive regulation of B lymphocyte cytokine production" EXACT [] synonym: "positive regulation of B-cell cytokine production" EXACT [] synonym: "positive regulation of B-lymphocyte cytokine production" EXACT [] synonym: "stimulation of B cell cytokine production" NARROW [] synonym: "up regulation of B cell cytokine production" EXACT [] synonym: "up-regulation of B cell cytokine production" EXACT [] synonym: "upregulation of B cell cytokine production" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production relationship: positively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002724 name: regulation of T cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "regulation of T lymphocyte cytokine production" EXACT [] synonym: "regulation of T-cell cytokine production" EXACT [] synonym: "regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002725 name: negative regulation of T cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "down regulation of T cell cytokine production" EXACT [] synonym: "down-regulation of T cell cytokine production" EXACT [] synonym: "downregulation of T cell cytokine production" EXACT [] synonym: "inhibition of T cell cytokine production" NARROW [] synonym: "negative regulation of T lymphocyte cytokine production" EXACT [] synonym: "negative regulation of T-cell cytokine production" EXACT [] synonym: "negative regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production relationship: negatively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002726 name: positive regulation of T cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "activation of T cell cytokine production" NARROW [] synonym: "positive regulation of T lymphocyte cytokine production" EXACT [] synonym: "positive regulation of T-cell cytokine production" EXACT [] synonym: "positive regulation of T-lymphocyte cytokine production" EXACT [] synonym: "stimulation of T cell cytokine production" NARROW [] synonym: "up regulation of T cell cytokine production" EXACT [] synonym: "up-regulation of T cell cytokine production" EXACT [] synonym: "upregulation of T cell cytokine production" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production relationship: positively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002727 name: regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "regulation of NK cell cytokine production" EXACT [] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002728 name: negative regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "down regulation of natural killer cell cytokine production" EXACT [] synonym: "down-regulation of natural killer cell cytokine production" EXACT [] synonym: "downregulation of natural killer cell cytokine production" EXACT [] synonym: "inhibition of natural killer cell cytokine production" NARROW [] synonym: "negative regulation of NK cell cytokine production" EXACT [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002729 name: positive regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "activation of natural killer cell cytokine production" NARROW [] synonym: "positive regulation of NK cell cytokine production" EXACT [] synonym: "stimulation of natural killer cell cytokine production" NARROW [] synonym: "up regulation of natural killer cell cytokine production" EXACT [] synonym: "up-regulation of natural killer cell cytokine production" EXACT [] synonym: "upregulation of natural killer cell cytokine production" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002730 name: regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002731 name: negative regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "down regulation of dendritic cell cytokine production" EXACT [] synonym: "down-regulation of dendritic cell cytokine production" EXACT [] synonym: "downregulation of dendritic cell cytokine production" EXACT [] synonym: "inhibition of dendritic cell cytokine production" NARROW [] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002732 name: positive regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "activation of dendritic cell cytokine production" NARROW [] synonym: "stimulation of dendritic cell cytokine production" NARROW [] synonym: "up regulation of dendritic cell cytokine production" EXACT [] synonym: "up-regulation of dendritic cell cytokine production" EXACT [] synonym: "upregulation of dendritic cell cytokine production" EXACT [] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002733 name: regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002734 name: negative regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002735 name: positive regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "activation of myeloid dendritic cell cytokine production" NARROW [] synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW [] synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002736 name: regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002737 name: negative regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002738 name: positive regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002739 name: regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0050707 ! regulation of cytokine secretion relationship: regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002740 name: negative regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine secretion during immune response" RELATED [] synonym: "down-regulation of cytokine secretion during immune response" RELATED [] synonym: "downregulation of cytokine secretion during immune response" RELATED [] synonym: "inhibition of cytokine secretion during immune response" NARROW [] synonym: "negative regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050710 ! negative regulation of cytokine secretion relationship: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002741 name: positive regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "activation of cytokine secretion during immune response" NARROW [] synonym: "positive regulation of cytokine secretion during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine secretion during immune response" NARROW [] synonym: "up regulation of cytokine secretion during immune response" RELATED [] synonym: "up-regulation of cytokine secretion during immune response" RELATED [] synonym: "upregulation of cytokine secretion during immune response" RELATED [] is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050715 ! positive regulation of cytokine secretion relationship: positively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002742 name: regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002743 name: negative regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "down-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "downregulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW [] synonym: "negative regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002744 name: positive regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "activation of cytokine biosynthetic process during immune response" NARROW [] synonym: "positive regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW [] synonym: "up regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "up-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "upregulation of cytokine biosynthetic process during immune response" RELATED [] is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002745 name: antigen processing and presentation initiated by receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002746 name: antigen processing and presentation following pinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002747 name: antigen processing and presentation following phagocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002748 name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT [] synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT [] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002749 name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15596122] synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT [] is_a: GO:0002747 ! antigen processing and presentation following phagocytosis is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen [Term] id: GO:0002750 name: antigen processing and presentation following macropinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257] is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002751 name: antigen processing and presentation following receptor mediated endocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002752 name: cell surface pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a cell surface pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "cell surface PAMP receptor signaling pathway" EXACT [] synonym: "cell surface pathogen receptor signaling pathway" EXACT [] synonym: "cell surface pattern recognition receptor signalling pathway" EXACT [] synonym: "cell surface PRR signaling pathway" EXACT [] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002753 name: cytoplasmic pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located in the cytoplasm. Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT [] synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT [] synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT [] synonym: "cytoplasmic PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0002754 name: intracellular vesicle pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located within the membrane of an intracellular vesicle such as an endosome or lysosome. Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "intracellular vesicle PAMP receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pathogen receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pattern recognition receptor signalling pathway" EXACT [] synonym: "intracellular vesicle PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0002755 name: MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-dependent TLR signaling pathway" EXACT [] synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT [] xref: Reactome:1253142 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1253158 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1280076 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1280092 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1298957 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1298974 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1326647 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1326663 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1352759 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1352775 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1372970 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1372986 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1392986 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1393002 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1417466 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1417482 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1450559 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1450575 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1471065 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1471082 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1483081 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1483098 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1496956 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1496973 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1514343 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1514360 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1521216 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1521232 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1526804 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1526821 "MyD88 cascade initiated on plasma membrane" xref: Reactome:1532530 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:1532547 "MyD88 cascade initiated on plasma membrane" xref: Reactome:166058 "MyD88:Mal cascade initiated on plasma membrane" xref: Reactome:451477 "MyD88-dependent cascade initiated on endosome membrane" xref: Reactome:451514 "MyD88:TIRAP-dependent cascade initiated on plasma membrane" xref: Reactome:975871 "MyD88 cascade initiated on plasma membrane" xref: Reactome:977240 "MyD88 cascade initiated on plasma membrane" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002756 name: MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-independent TLR signaling pathway" EXACT [] synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT [] xref: Reactome:1253150 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1253153 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1253361 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:1253367 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:1280084 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1280087 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1280301 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:1280307 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:1298966 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1298969 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1299153 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:1299160 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:1326655 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1326658 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1326879 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:1326885 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:1352767 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1352770 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1352971 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:1352977 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:1372978 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1372981 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1373173 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:1373175 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:1392994 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1392997 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1393184 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:1393186 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:1417474 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1417477 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1417676 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:1417680 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:1450567 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1450570 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1450777 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:1450783 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:1471074 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1471077 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1483090 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1483093 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1496965 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1496968 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1514352 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1514355 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1521224 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1521227 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1526813 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1526816 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:1532539 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:1532542 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:166166 "MyD88-independent cascade initiated on plasma membrane" xref: Reactome:168180 "TRAF6 Mediated Induction of proinflammatory cytokines" xref: Reactome:168927 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:168936 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002757 name: immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add] is_a: GO:0002253 ! activation of immune response is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002758 name: innate immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002757 ! immune response-activating signal transduction [Term] id: GO:0002759 name: regulation of antimicrobial humoral response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002760 name: positive regulation of antimicrobial humoral response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] synonym: "activation of antimicrobial humoral response" NARROW [] synonym: "stimulation of antimicrobial humoral response" NARROW [] synonym: "up regulation of antimicrobial humoral response" EXACT [] synonym: "up-regulation of antimicrobial humoral response" EXACT [] synonym: "upregulation of antimicrobial humoral response" EXACT [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0043902 ! positive regulation of multi-organism process relationship: positively_regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation relationship: regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "activation of myeloid leukocyte differentiation" NARROW [] synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002764 name: immune response-regulating signaling pathway namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "immune response-regulating signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0002765 name: immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002766 name: innate immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] is_a: GO:0002765 ! immune response-inhibiting signal transduction [Term] id: GO:0002767 name: immune response-inhibiting cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT [] is_a: GO:0002765 ! immune response-inhibiting signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002768 name: immune response-regulating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002764 ! immune response-regulating signaling pathway is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0002769 name: natural killer cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "inhibitory KIR signaling pathway" NARROW [] synonym: "killer cell inhibitory receptor signaling pathway" NARROW [] synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] synonym: "natural killer cell inhibitory signalling pathway" EXACT [] synonym: "NK cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002770 name: T cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309] synonym: "T cell inhibitory signalling pathway" EXACT [] synonym: "T lymphocyte inhibitory signaling pathway" EXACT [] synonym: "T-cell inhibitory signaling pathway" EXACT [] synonym: "T-lymphocyte inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002771 name: inhibitory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "killer cell inhibitory receptor signaling pathway" EXACT [] synonym: "KIR signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002772 name: inhibitory C-type lectin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT [] synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002773 name: B cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920] synonym: "B cell inhibitory signalling pathway" EXACT [] synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT [] synonym: "B-cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002774 name: Fc receptor mediated inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT [] synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002775 name: antimicrobial peptide production namespace: biological_process def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002440 ! production of molecular mediator of immune response relationship: part_of GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002776 name: antimicrobial peptide secretion namespace: biological_process def: "The regulated release of an antimicrobial peptide from a cell or group of cells. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002790 ! peptide secretion relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002777 name: antimicrobial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0043043 ! peptide biosynthetic process relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002778 name: antibacterial peptide production namespace: biological_process def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019731 ! antibacterial humoral response [Term] id: GO:0002779 name: antibacterial peptide secretion namespace: biological_process def: "The regulated release of an antibacterial peptide from a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002780 name: antibacterial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002781 name: antifungal peptide production namespace: biological_process def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019732 ! antifungal humoral response [Term] id: GO:0002782 name: antifungal peptide secretion namespace: biological_process def: "The regulated release of an antifungal peptide from a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002783 name: antifungal peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002784 name: regulation of antimicrobial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0002759 ! regulation of antimicrobial humoral response relationship: regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002785 name: negative regulation of antimicrobial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] synonym: "down regulation of antimicrobial peptide production" EXACT [] synonym: "down-regulation of antimicrobial peptide production" EXACT [] synonym: "downregulation of antimicrobial peptide production" EXACT [] synonym: "inhibition of antimicrobial peptide production" NARROW [] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002784 ! regulation of antimicrobial peptide production relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002786 name: regulation of antibacterial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0031347 ! regulation of defense response relationship: regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002787 name: negative regulation of antibacterial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "down regulation of antibacterial peptide production" EXACT [] synonym: "down-regulation of antibacterial peptide production" EXACT [] synonym: "downregulation of antibacterial peptide production" EXACT [] synonym: "inhibition of antibacterial peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production relationship: negatively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002788 name: regulation of antifungal peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0031347 ! regulation of defense response relationship: regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002789 name: negative regulation of antifungal peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "down regulation of antifungal peptide production" EXACT [] synonym: "down-regulation of antifungal peptide production" EXACT [] synonym: "downregulation of antifungal peptide production" EXACT [] synonym: "inhibition of antifungal peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production relationship: negatively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or group of cells." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport relationship: regulates GO:0002790 ! peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion relationship: negatively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion relationship: positively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002794 name: regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0002791 ! regulation of peptide secretion relationship: regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002795 name: negative regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "down regulation of antimicrobial peptide secretion" EXACT [] synonym: "down-regulation of antimicrobial peptide secretion" EXACT [] synonym: "downregulation of antimicrobial peptide secretion" EXACT [] synonym: "inhibition of antimicrobial peptide secretion" NARROW [] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002796 name: positive regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "activation of antimicrobial peptide secretion" NARROW [] synonym: "stimulation of antimicrobial peptide secretion" NARROW [] synonym: "up regulation of antimicrobial peptide secretion" EXACT [] synonym: "up-regulation of antimicrobial peptide secretion" EXACT [] synonym: "upregulation of antimicrobial peptide secretion" EXACT [] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002797 name: regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002798 name: negative regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "down regulation of antibacterial peptide secretion" EXACT [] synonym: "down-regulation of antibacterial peptide secretion" EXACT [] synonym: "downregulation of antibacterial peptide secretion" EXACT [] synonym: "inhibition of antibacterial peptide secretion" NARROW [] is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002799 name: positive regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "activation of antibacterial peptide secretion" NARROW [] synonym: "stimulation of antibacterial peptide secretion" NARROW [] synonym: "up regulation of antibacterial peptide secretion" EXACT [] synonym: "up-regulation of antibacterial peptide secretion" EXACT [] synonym: "upregulation of antibacterial peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002800 name: regulation of antifungal peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002801 name: negative regulation of antifungal peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "down regulation of antifungal peptide secretion" EXACT [] synonym: "down-regulation of antifungal peptide secretion" EXACT [] synonym: "downregulation of antifungal peptide secretion" EXACT [] synonym: "inhibition of antifungal peptide secretion" NARROW [] is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002802 name: positive regulation of antifungal peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "activation of antifungal peptide secretion" NARROW [] synonym: "stimulation of antifungal peptide secretion" NARROW [] synonym: "up regulation of antifungal peptide secretion" EXACT [] synonym: "up-regulation of antifungal peptide secretion" EXACT [] synonym: "upregulation of antifungal peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion relationship: positively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002803 name: positive regulation of antibacterial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "activation of antibacterial peptide production" NARROW [] synonym: "stimulation of antibacterial peptide production" NARROW [] synonym: "up regulation of antibacterial peptide production" EXACT [] synonym: "up-regulation of antibacterial peptide production" EXACT [] synonym: "upregulation of antibacterial peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production relationship: positively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002804 name: positive regulation of antifungal peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "activation of antifungal peptide production" NARROW [] synonym: "stimulation of antifungal peptide production" NARROW [] synonym: "up regulation of antifungal peptide production" EXACT [] synonym: "up-regulation of antifungal peptide production" EXACT [] synonym: "upregulation of antifungal peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production relationship: positively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002805 name: regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002806 name: negative regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW [] is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002807 name: positive regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "activation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT [] is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002808 name: regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002809 name: negative regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW [] is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002810 name: regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002811 name: negative regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] synonym: "down regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "downregulation of antifungal peptide biosynthetic process" EXACT [] synonym: "inhibition of antifungal peptide biosynthetic process" NARROW [] is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002812 name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium [Term] id: GO:0002813 name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002814 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002815 name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium [Term] id: GO:0002816 name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002817 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002818 name: intracellular defense response namespace: biological_process def: "A physiological defense response which occurs intracellularly." [GOC:add] synonym: "intracellular defence response" EXACT [] is_a: GO:0006968 ! cellular defense response is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0002819 name: regulation of adaptive immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "down regulation of adaptive immune response" EXACT [] synonym: "down-regulation of adaptive immune response" EXACT [] synonym: "downregulation of adaptive immune response" EXACT [] synonym: "inhibition of adaptive immune response" NARROW [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "activation of adaptive immune response" NARROW [] synonym: "stimulation of adaptive immune response" NARROW [] synonym: "up regulation of adaptive immune response" EXACT [] synonym: "up-regulation of adaptive immune response" EXACT [] synonym: "upregulation of adaptive immune response" EXACT [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002825 name: regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002826 name: negative regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "down regulation of T-helper 1 type immune response" EXACT [] synonym: "down-regulation of T-helper 1 type immune response" EXACT [] synonym: "downregulation of T-helper 1 type immune response" EXACT [] synonym: "inhibition of T-helper 1 type immune response" NARROW [] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002827 name: positive regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "activation of T-helper 1 type immune response" NARROW [] synonym: "stimulation of T-helper 1 type immune response" NARROW [] synonym: "up regulation of T-helper 1 type immune response" EXACT [] synonym: "up-regulation of T-helper 1 type immune response" EXACT [] synonym: "upregulation of T-helper 1 type immune response" EXACT [] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002828 name: regulation of type 2 immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002829 name: negative regulation of type 2 immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "down regulation of type 2 immune response" EXACT [] synonym: "down-regulation of type 2 immune response" EXACT [] synonym: "downregulation of type 2 immune response" EXACT [] synonym: "inhibition of type 2 immune response" NARROW [] synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "negative regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002830 name: positive regulation of type 2 immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "activation of type 2 immune response" NARROW [] synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "positive regulation of Th2 immune response" NARROW [GOC:add] synonym: "stimulation of type 2 immune response" NARROW [] synonym: "up regulation of type 2 immune response" EXACT [] synonym: "up-regulation of type 2 immune response" EXACT [] synonym: "upregulation of type 2 immune response" EXACT [] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002834 name: regulation of response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "regulation of response to tumour cell" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus relationship: regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002835 name: negative regulation of response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "down regulation of response to tumor cell" EXACT [] synonym: "down-regulation of response to tumor cell" EXACT [] synonym: "downregulation of response to tumor cell" EXACT [] synonym: "inhibition of response to tumor cell" NARROW [] synonym: "negative regulation of response to tumour cell" EXACT [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell relationship: negatively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002836 name: positive regulation of response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "activation of response to tumor cell" NARROW [] synonym: "positive regulation of response to tumour cell" EXACT [] synonym: "stimulation of response to tumor cell" NARROW [] synonym: "up regulation of response to tumor cell" EXACT [] synonym: "up-regulation of response to tumor cell" EXACT [] synonym: "upregulation of response to tumor cell" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell relationship: positively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002837 name: regulation of immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "regulation of immune response to tumour cell" EXACT [] is_a: GO:0002834 ! regulation of response to tumor cell is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002838 name: negative regulation of immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "down regulation of immune response to tumor cell" EXACT [] synonym: "down-regulation of immune response to tumor cell" EXACT [] synonym: "downregulation of immune response to tumor cell" EXACT [] synonym: "inhibition of immune response to tumor cell" NARROW [] synonym: "negative regulation of immune response to tumour cell" EXACT [] is_a: GO:0002835 ! negative regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002839 name: positive regulation of immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "activation of immune response to tumor cell" NARROW [] synonym: "positive regulation of immune response to tumour cell" EXACT [] synonym: "stimulation of immune response to tumor cell" NARROW [] synonym: "up regulation of immune response to tumor cell" EXACT [] synonym: "up-regulation of immune response to tumor cell" EXACT [] synonym: "upregulation of immune response to tumor cell" EXACT [] is_a: GO:0002836 ! positive regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002840 name: regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002841 name: negative regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW [] synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002842 name: positive regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "activation of T cell mediated immune response to tumor cell" NARROW [] synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002843 name: regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002837 ! regulation of immune response to tumor cell relationship: regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002844 name: negative regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of tolerance induction to tumor cell" EXACT [] synonym: "downregulation of tolerance induction to tumor cell" EXACT [] synonym: "inhibition of tolerance induction to tumor cell" NARROW [] synonym: "negative regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002845 name: positive regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "activation of tolerance induction to tumor cell" NARROW [] synonym: "positive regulation of tolerance induction to tumour cell" EXACT [] synonym: "stimulation of tolerance induction to tumor cell" NARROW [] synonym: "up regulation of tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of tolerance induction to tumor cell" EXACT [] synonym: "upregulation of tolerance induction to tumor cell" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002846 name: regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002847 name: negative regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW [] is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002848 name: positive regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "activation of T cell tolerance induction to tumor cell" NARROW [] synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW [] synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT [] is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002849 name: regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002709 ! regulation of T cell mediated immunity relationship: regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002850 name: negative regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "down regulation of peripheral T cell tolerance induction" EXACT [] synonym: "down-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "downregulation of peripheral T cell tolerance induction" EXACT [] synonym: "inhibition of peripheral T cell tolerance induction" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002851 name: positive regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "activation of peripheral T cell tolerance induction" NARROW [] synonym: "stimulation of peripheral T cell tolerance induction" NARROW [] synonym: "up regulation of peripheral T cell tolerance induction" EXACT [] synonym: "up-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "upregulation of peripheral T cell tolerance induction" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002852 name: regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002853 name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002854 name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002855 name: regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002856 name: negative regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002857 name: positive regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002858 name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002859 name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002860 name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002861 name: regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002862 name: negative regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002863 name: positive regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002864 name: regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002865 name: negative regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002866 name: positive regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002867 name: regulation of B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "regulation of B lymphocyte deletion" EXACT [] synonym: "regulation of B-cell deletion" EXACT [] synonym: "regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002902 ! regulation of B cell apoptosis relationship: regulates GO:0002516 ! B cell deletion [Term] id: GO:0002868 name: negative regulation of B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "down regulation of B cell deletion" EXACT [] synonym: "down-regulation of B cell deletion" EXACT [] synonym: "downregulation of B cell deletion" EXACT [] synonym: "inhibition of B cell deletion" NARROW [] synonym: "negative regulation of B lymphocyte deletion" EXACT [] synonym: "negative regulation of B-cell deletion" EXACT [] synonym: "negative regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002903 ! negative regulation of B cell apoptosis relationship: negatively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002869 name: positive regulation of B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "activation of B cell deletion" NARROW [] synonym: "positive regulation of B lymphocyte deletion" EXACT [] synonym: "positive regulation of B-cell deletion" EXACT [] synonym: "positive regulation of B-lymphocyte deletion" EXACT [] synonym: "stimulation of B cell deletion" NARROW [] synonym: "up regulation of B cell deletion" EXACT [] synonym: "up-regulation of B cell deletion" EXACT [] synonym: "upregulation of B cell deletion" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002904 ! positive regulation of B cell apoptosis relationship: positively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002870 name: T cell anergy namespace: biological_process def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte anergy" EXACT [] synonym: "T-cell anergy" EXACT [] synonym: "T-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002871 name: regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002872 name: negative regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "down regulation of natural killer cell tolerance induction" EXACT [] synonym: "down-regulation of natural killer cell tolerance induction" EXACT [] synonym: "downregulation of natural killer cell tolerance induction" EXACT [] synonym: "inhibition of natural killer cell tolerance induction" NARROW [] synonym: "negative regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002873 name: positive regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "activation of natural killer cell tolerance induction" NARROW [] synonym: "positive regulation of NK cell tolerance induction" EXACT [] synonym: "stimulation of natural killer cell tolerance induction" NARROW [] synonym: "up regulation of natural killer cell tolerance induction" EXACT [] synonym: "up-regulation of natural killer cell tolerance induction" EXACT [] synonym: "upregulation of natural killer cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002874 name: regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002875 name: negative regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002876 name: positive regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002877 name: regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002878 name: negative regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002879 name: positive regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002880 name: regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002881 name: negative regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002882 name: positive regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002883 name: regulation of hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add] is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus relationship: regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002884 name: negative regulation of hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "down regulation of hypersensitivity" EXACT [] synonym: "down-regulation of hypersensitivity" EXACT [] synonym: "downregulation of hypersensitivity" EXACT [] synonym: "inhibition of hypersensitivity" NARROW [] is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity relationship: negatively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002885 name: positive regulation of hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "activation of hypersensitivity" NARROW [] synonym: "stimulation of hypersensitivity" NARROW [] synonym: "up regulation of hypersensitivity" EXACT [] synonym: "up-regulation of hypersensitivity" EXACT [] synonym: "upregulation of hypersensitivity" EXACT [] is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity relationship: positively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002889 name: regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] is_a: GO:0002712 ! regulation of B cell mediated immunity relationship: regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002890 name: negative regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "down regulation of immunoglobulin mediated immune response" EXACT [] synonym: "down-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "downregulation of immunoglobulin mediated immune response" EXACT [] synonym: "inhibition of immunoglobulin mediated immune response" NARROW [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002891 name: positive regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "activation of immunoglobulin mediated immune response" NARROW [] synonym: "stimulation of immunoglobulin mediated immune response" NARROW [] synonym: "up regulation of immunoglobulin mediated immune response" EXACT [] synonym: "up-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "upregulation of immunoglobulin mediated immune response" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002892 name: regulation of type II hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002893 name: negative regulation of type II hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "down regulation of type II hypersensitivity" EXACT [] synonym: "down-regulation of type II hypersensitivity" EXACT [] synonym: "downregulation of type II hypersensitivity" EXACT [] synonym: "inhibition of type II hypersensitivity" NARROW [] is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: negatively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002894 name: positive regulation of type II hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "activation of type II hypersensitivity" NARROW [] synonym: "stimulation of type II hypersensitivity" NARROW [] synonym: "up regulation of type II hypersensitivity" EXACT [] synonym: "up-regulation of type II hypersensitivity" EXACT [] synonym: "upregulation of type II hypersensitivity" EXACT [] is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: positively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002895 name: regulation of central B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] is_a: GO:0002646 ! regulation of central tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction relationship: regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002896 name: negative regulation of central B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "down regulation of central B cell tolerance induction" EXACT [] synonym: "down-regulation of central B cell tolerance induction" EXACT [] synonym: "downregulation of central B cell tolerance induction" EXACT [] synonym: "inhibition of central B cell tolerance induction" NARROW [] is_a: GO:0002647 ! negative regulation of central tolerance induction is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002897 name: positive regulation of central B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "activation of central B cell tolerance induction" NARROW [] synonym: "stimulation of central B cell tolerance induction" NARROW [] synonym: "up regulation of central B cell tolerance induction" EXACT [] synonym: "up-regulation of central B cell tolerance induction" EXACT [] synonym: "upregulation of central B cell tolerance induction" EXACT [] is_a: GO:0002648 ! positive regulation of central tolerance induction is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction relationship: positively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002898 name: regulation of central B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add] is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation relationship: regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002899 name: negative regulation of central B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "down regulation of central B cell deletion" EXACT [] synonym: "down-regulation of central B cell deletion" EXACT [] synonym: "downregulation of central B cell deletion" EXACT [] synonym: "inhibition of central B cell deletion" NARROW [] is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002898 ! regulation of central B cell deletion relationship: negatively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002900 name: positive regulation of central B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "activation of central B cell deletion" NARROW [] synonym: "stimulation of central B cell deletion" NARROW [] synonym: "up regulation of central B cell deletion" EXACT [] synonym: "up-regulation of central B cell deletion" EXACT [] synonym: "upregulation of central B cell deletion" EXACT [] is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002898 ! regulation of central B cell deletion relationship: positively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002901 name: mature B cell apoptosis namespace: biological_process def: "The process of apoptosis in mature B cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "apoptosis of mature B cells" EXACT [] synonym: "apoptosis of mature B lymphocytes" EXACT [] synonym: "apoptosis of mature B-cells" EXACT [] synonym: "apoptosis of mature B-lymphocytes" EXACT [] synonym: "mature B cell programmed cell death by apoptosis" EXACT [] synonym: "mature B lymphocyte apoptosis" EXACT [] synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "mature B-cell apoptosis" EXACT [] synonym: "mature B-cell programmed cell death by apoptosis" EXACT [] synonym: "mature B-lymphocyte apoptosis" EXACT [] synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of mature B cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of mature B-cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, mature B cells" EXACT [] synonym: "programmed cell death, mature B lymphocytes" EXACT [] synonym: "programmed cell death, mature B-cells" EXACT [] synonym: "programmed cell death, mature B-lymphocytes" EXACT [] is_a: GO:0001783 ! B cell apoptosis relationship: part_of GO:0001782 ! B cell homeostasis [Term] id: GO:0002902 name: regulation of B cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell apoptosis." [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptosis relationship: regulates GO:0001783 ! B cell apoptosis [Term] id: GO:0002903 name: negative regulation of B cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptosis." [GOC:add] synonym: "down regulation of B cell apoptosis" EXACT [] synonym: "down-regulation of B cell apoptosis" EXACT [] synonym: "downregulation of B cell apoptosis" EXACT [] synonym: "inhibition of B cell apoptosis" NARROW [] is_a: GO:0002902 ! regulation of B cell apoptosis is_a: GO:0070229 ! negative regulation of lymphocyte apoptosis relationship: negatively_regulates GO:0001783 ! B cell apoptosis [Term] id: GO:0002904 name: positive regulation of B cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptosis." [GOC:add] synonym: "activation of B cell apoptosis" NARROW [] synonym: "stimulation of B cell apoptosis" NARROW [] synonym: "up regulation of B cell apoptosis" EXACT [] synonym: "up-regulation of B cell apoptosis" EXACT [] synonym: "upregulation of B cell apoptosis" EXACT [] is_a: GO:0002902 ! regulation of B cell apoptosis is_a: GO:0070230 ! positive regulation of lymphocyte apoptosis relationship: positively_regulates GO:0001783 ! B cell apoptosis [Term] id: GO:0002905 name: regulation of mature B cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptosis." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0002902 ! regulation of B cell apoptosis is_a: GO:0032844 ! regulation of homeostatic process relationship: regulates GO:0002901 ! mature B cell apoptosis [Term] id: GO:0002906 name: negative regulation of mature B cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptosis." [GOC:add] synonym: "down regulation of mature B cell apoptosis" EXACT [] synonym: "down-regulation of mature B cell apoptosis" EXACT [] synonym: "downregulation of mature B cell apoptosis" EXACT [] synonym: "inhibition of mature B cell apoptosis" NARROW [] is_a: GO:0002903 ! negative regulation of B cell apoptosis is_a: GO:0002905 ! regulation of mature B cell apoptosis relationship: negatively_regulates GO:0002901 ! mature B cell apoptosis [Term] id: GO:0002907 name: positive regulation of mature B cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptosis." [GOC:add] synonym: "activation of mature B cell apoptosis" NARROW [] synonym: "stimulation of mature B cell apoptosis" NARROW [] synonym: "up regulation of mature B cell apoptosis" EXACT [] synonym: "up-regulation of mature B cell apoptosis" EXACT [] synonym: "upregulation of mature B cell apoptosis" EXACT [] is_a: GO:0002904 ! positive regulation of B cell apoptosis is_a: GO:0002905 ! regulation of mature B cell apoptosis relationship: positively_regulates GO:0002901 ! mature B cell apoptosis [Term] id: GO:0002908 name: regulation of peripheral B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002867 ! regulation of B cell deletion relationship: regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002909 name: negative regulation of peripheral B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "down regulation of peripheral B cell deletion" EXACT [] synonym: "down-regulation of peripheral B cell deletion" EXACT [] synonym: "downregulation of peripheral B cell deletion" EXACT [] synonym: "inhibition of peripheral B cell deletion" NARROW [] is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002910 name: positive regulation of peripheral B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "activation of peripheral B cell deletion" NARROW [] synonym: "stimulation of peripheral B cell deletion" NARROW [] synonym: "up regulation of peripheral B cell deletion" EXACT [] synonym: "up-regulation of peripheral B cell deletion" EXACT [] synonym: "upregulation of peripheral B cell deletion" EXACT [] is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion relationship: positively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002911 name: regulation of lymphocyte anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002912 name: negative regulation of lymphocyte anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "down regulation of lymphocyte anergy" EXACT [] synonym: "down-regulation of lymphocyte anergy" EXACT [] synonym: "downregulation of lymphocyte anergy" EXACT [] synonym: "inhibition of lymphocyte anergy" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: negatively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002913 name: positive regulation of lymphocyte anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "activation of lymphocyte anergy" NARROW [] synonym: "stimulation of lymphocyte anergy" NARROW [] synonym: "up regulation of lymphocyte anergy" EXACT [] synonym: "up-regulation of lymphocyte anergy" EXACT [] synonym: "upregulation of lymphocyte anergy" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: positively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002914 name: regulation of central B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add] is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation relationship: regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002915 name: negative regulation of central B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "down regulation of central B cell anergy" EXACT [] synonym: "down-regulation of central B cell anergy" EXACT [] synonym: "downregulation of central B cell anergy" EXACT [] synonym: "inhibition of central B cell anergy" NARROW [] is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002914 ! regulation of central B cell anergy relationship: negatively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002916 name: positive regulation of central B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "activation of central B cell anergy" NARROW [] synonym: "stimulation of central B cell anergy" NARROW [] synonym: "up regulation of central B cell anergy" EXACT [] synonym: "up-regulation of central B cell anergy" EXACT [] synonym: "upregulation of central B cell anergy" EXACT [] is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002914 ! regulation of central B cell anergy relationship: positively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002917 name: regulation of peripheral B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002712 ! regulation of B cell mediated immunity relationship: regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002918 name: negative regulation of peripheral B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "down regulation of peripheral B cell anergy" EXACT [] synonym: "down-regulation of peripheral B cell anergy" EXACT [] synonym: "downregulation of peripheral B cell anergy" EXACT [] synonym: "inhibition of peripheral B cell anergy" NARROW [] is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002917 ! regulation of peripheral B cell anergy relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002919 name: positive regulation of peripheral B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "activation of peripheral B cell anergy" NARROW [] synonym: "stimulation of peripheral B cell anergy" NARROW [] synonym: "up regulation of peripheral B cell anergy" EXACT [] synonym: "up-regulation of peripheral B cell anergy" EXACT [] synonym: "upregulation of peripheral B cell anergy" EXACT [] is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002917 ! regulation of peripheral B cell anergy relationship: positively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002920 name: regulation of humoral immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0006959 ! humoral immune response [Term] id: GO:0002921 name: negative regulation of humoral immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "down regulation of humoral immune response" EXACT [] synonym: "down-regulation of humoral immune response" EXACT [] synonym: "downregulation of humoral immune response" EXACT [] synonym: "inhibition of humoral immune response" NARROW [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002922 name: positive regulation of humoral immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "activation of humoral immune response" NARROW [] synonym: "stimulation of humoral immune response" NARROW [] synonym: "up regulation of humoral immune response" EXACT [] synonym: "up-regulation of humoral immune response" EXACT [] synonym: "upregulation of humoral immune response" EXACT [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002923 name: regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0002920 ! regulation of humoral immune response relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002924 name: negative regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW [] is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002925 name: positive regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0003001 name: generation of a signal involved in cell-cell signaling namespace: biological_process def: "The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph] synonym: "formation of a signal" BROAD [] synonym: "generation of a signal involved in cell-cell signalling" EXACT [] synonym: "signal generation" BROAD [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0007267 ! cell-cell signaling [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003003 name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage namespace: biological_process def: "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during fused antrum stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0003004 name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage namespace: biological_process def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048164 ! distinct antral spaces stage [Term] id: GO:0003005 name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage namespace: biological_process def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048163 ! scattered antral spaces stage [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003009 name: skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction relationship: part_of GO:0050881 ! musculoskeletal movement [Term] id: GO:0003010 name: voluntary skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003011 name: involuntary skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003012 name: muscle system process namespace: biological_process def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] synonym: "muscle physiological process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process [Term] id: GO:0003014 name: renal system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism." [GOC:mtg_cardio] synonym: "kidney system process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003016 name: respiratory system process namespace: biological_process alt_id: GO:0010802 def: "A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "respiratory gaseous exchange by respiratory system" EXACT [] is_a: GO:0003008 ! system process is_a: GO:0007585 ! respiratory gaseous exchange [Term] id: GO:0003017 name: lymph circulation namespace: biological_process def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003018 name: vascular process in circulatory system namespace: biological_process def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio] synonym: "vasculature process" EXACT [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003019 name: central nervous system control of baroreceptor feedback namespace: biological_process def: "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0003020 name: detection of reduced oxygen by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0070483 ! detection of hypoxia relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003021 name: detection of increased carbon dioxide by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003022 name: detection of pH by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003030 ! detection of hydrogen ion relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003023 name: baroreceptor detection of increased arterial stretch namespace: biological_process def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0003024 name: baroreceptor detection of decreased arterial stretch namespace: biological_process def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0003025 name: regulation of systemic arterial blood pressure by baroreceptor feedback namespace: biological_process def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003026 name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0003027 name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah] synonym: "vagal reflex" BROAD [] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003028 name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "aortic body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003029 name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003030 name: detection of hydrogen ion namespace: biological_process def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003031 name: detection of carbon dioxide namespace: biological_process def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003032 name: detection of oxygen namespace: biological_process def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003033 name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003034 name: detection of increased carbon dioxide by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003035 name: detection of increased carbon dioxide by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003036 name: detection of pH by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003037 name: detection of pH by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003038 name: detection of reduced oxygen by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003039 name: detection of reduced oxygen by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003040 name: excitation of vasomotor center by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003041 name: excitation of vasomotor center by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003042 name: vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951 "Principles of Physiology"] synonym: "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003043 name: vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio] synonym: "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003044 name: regulation of systemic arterial blood pressure mediated by a chemical signal namespace: biological_process def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "blood pressure regulation mediated by a chemical signal" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003045 name: regulation of systemic arterial blood pressure by physical factors namespace: biological_process def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by physical factors" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003046 name: regulation of systemic arterial blood pressure by stress relaxation namespace: biological_process def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by stress relaxation" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0003047 name: regulation of systemic arterial blood pressure by epinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by epinephrine" RELATED [] synonym: "regulation of blood pressure by adrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003048 name: regulation of systemic arterial blood pressure by norepinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by norepinephrine" RELATED [] synonym: "regulation of blood pressure by noradrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003049 name: regulation of systemic arterial blood pressure by capillary fluid shift namespace: biological_process def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by capillary fluid shift" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors [Term] id: GO:0003050 name: regulation of systemic arterial blood pressure by atrial natriuretic peptide namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio] synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio] synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003051 name: angiotensin-mediated drinking behavior namespace: biological_process def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio] synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb] is_a: GO:0042756 ! drinking behavior relationship: part_of GO:0002035 ! brain renin-angiotensin system [Term] id: GO:0003052 name: circadian regulation of systemic arterial blood pressure namespace: biological_process def: "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] is_a: GO:0003073 ! regulation of systemic arterial blood pressure is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0003053 name: circadian regulation of heart rate namespace: biological_process def: "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate" RELATED [] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0003054 name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus namespace: biological_process def: "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "master pacemaker clock regulation of blood pressure" EXACT [] synonym: "SCN regulation of blood pressure" EXACT [] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003055 name: circadian regulation of heart rate by the suprachiasmatic nucleus namespace: biological_process def: "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED [] synonym: "master pacemaker clock regulation of heart rate" EXACT [] synonym: "SCN regulation of heart rate" EXACT [] is_a: GO:0003053 ! circadian regulation of heart rate [Term] id: GO:0003056 name: regulation of vascular smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0019229 ! regulation of vasoconstriction relationship: regulates GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0003057 name: regulation of the force of heart contraction by chemical signal namespace: biological_process def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl] synonym: "chemical cardiac inotropy" EXACT [] synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0002026 ! regulation of the force of heart contraction [Term] id: GO:0003058 name: hormonal regulation of the force of heart contraction namespace: biological_process def: "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac inotropy" EXACT [] synonym: "hormonal regulation of the force of heart muscle contraction" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal [Term] id: GO:0003059 name: positive regulation of the force of heart contraction by epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac inotropy" EXACT [] synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac inotropy" EXACT [] synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003060 name: negative regulation of the force of heart contraction by acetylcholine namespace: biological_process def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "decreased force of heart contraction by acetylcholine" EXACT [] is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003061 name: positive regulation of the force of heart contraction by norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl] synonym: "increased force of heart contraction by adrenaline" RELATED [] synonym: "increased force of heart contraction by norepinephrine" EXACT [] synonym: "noradrenaline cardiac inotropy" EXACT [] synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac inotropy" EXACT [] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003062 name: regulation of heart rate by chemical signal namespace: biological_process def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb] synonym: "chemical cardiac chronotropy" EXACT [] synonym: "chemical signal regulation of heart contraction rate" RELATED [] synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate [Term] id: GO:0003063 name: negative regulation of heart rate by acetylcholine namespace: biological_process def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003064 name: regulation of heart rate by hormone namespace: biological_process def: "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac chronotropy" EXACT [] synonym: "regulation of the rate of heart contraction by hormone" EXACT [GOC:curators] is_a: GO:0003062 ! regulation of heart rate by chemical signal [Term] id: GO:0003065 name: positive regulation of heart rate by epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac chronotropy" EXACT [] synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003066 name: positive regulation of heart rate by norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "noradrenaline cardiac chronotropy" EXACT [] synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" EXACT [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003067 name: circadian regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003068 name: regulation of systemic arterial blood pressure by acetylcholine namespace: biological_process def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl] synonym: "blood pressure regulation by acetylcholine" EXACT [] is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter [Term] id: GO:0003069 name: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003070 name: regulation of systemic arterial blood pressure by neurotransmitter namespace: biological_process def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0003071 name: renal system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "renal control of blood pressure" EXACT [] synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0003014 ! renal system process relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003072 name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio] synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003073 name: regulation of systemic arterial blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0003074 name: regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035809 [Term] id: GO:0003075 name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio] synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure [Term] id: GO:0003077 name: negative regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035811 [Term] id: GO:0003078 name: regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035813 [Term] id: GO:0003079 name: positive regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035815 [Term] id: GO:0003080 name: negative regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035814 [Term] id: GO:0003081 name: regulation of systemic arterial blood pressure by renin-angiotensin namespace: biological_process def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by renin-angiotensin" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003082 name: positive regulation of renal output by angiotensin namespace: biological_process def: "OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0003083 name: negative regulation of renal output by angiotensin namespace: biological_process def: "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002019 ! regulation of renal output by angiotensin is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0003084 name: positive regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045777 ! positive regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003085 name: negative regulation of systemic arterial blood pressure namespace: biological_process def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045776 ! negative regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003086 name: regulation of systemic arterial blood pressure by local renal renin-angiotensin namespace: biological_process def: "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0003087 name: positive regulation of the force of heart contraction by neuronal epinephrine namespace: biological_process def: "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine [Term] id: GO:0003088 name: positive regulation of the force of heart contraction by circulating epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline" RELATED [] synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine [Term] id: GO:0003089 name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003090 name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003091 name: renal water homeostasis namespace: biological_process def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio] synonym: "water homeostasis by the kidney" EXACT [] is_a: GO:0003014 ! renal system process is_a: GO:0050891 ! multicellular organismal water homeostasis [Term] id: GO:0003092 name: renal water retention namespace: biological_process def: "The process in which renal water excretion is decreased." [GOC:mtg_cardio] synonym: "negative regulation of renal water excretion" EXACT [] is_a: GO:0035811 ! negative regulation of urine volume [Term] id: GO:0003093 name: regulation of glomerular filtration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003094 name: glomerular filtration namespace: biological_process def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0003014 ! renal system process [Term] id: GO:0003095 name: pressure natriuresis namespace: biological_process def: "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis)." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume [Term] id: GO:0003096 name: renal sodium ion transport namespace: biological_process def: "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006814 ! sodium ion transport [Term] id: GO:0003097 name: renal water transport namespace: biological_process def: "The directed movement of water (H2O) by the kidney." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006833 ! water transport relationship: part_of GO:0003091 ! renal water homeostasis [Term] id: GO:0003098 name: tubuloglomerular feedback namespace: biological_process def: "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio] xref: Wikipedia:Tubuloglomerular_feedback is_a: GO:0001977 ! renal system process involved in regulation of blood volume relationship: part_of GO:0003093 ! regulation of glomerular filtration [Term] id: GO:0003099 name: positive regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045823 ! positive regulation of heart contraction [Term] id: GO:0003100 name: regulation of systemic arterial blood pressure by endothelin namespace: biological_process def: "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003101 name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine namespace: biological_process def: "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003102 name: positive regulation of diuresis by angiotensin namespace: biological_process def: "OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb] is_obsolete: true consider: GO:0035810 [Term] id: GO:0003103 name: positive regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035810 [Term] id: GO:0003104 name: positive regulation of glomerular filtration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003105 name: negative regulation of glomerular filtration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003106 name: negative regulation of glomerular filtration by angiotensin namespace: biological_process def: "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb] synonym: "angiotensin-mediated regulation of glomerular filtration" BROAD [GOC:dph, GOC:tb] synonym: "regulation of glomerular filtration by angiotensin" BROAD [] is_a: GO:0003083 ! negative regulation of renal output by angiotensin relationship: part_of GO:0003105 ! negative regulation of glomerular filtration [Term] id: GO:0003107 name: positive regulation of natriuresis by angiotensin namespace: biological_process def: "OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0003108 name: negative regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045822 ! negative regulation of heart contraction [Term] id: GO:0003109 name: positive regulation of the force of heart contraction by circulating norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating noradrenaline" RELATED [] synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003110 name: positive regulation of the force of heart contraction by neuronal norepinephrine namespace: biological_process def: "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003111 name: positive regulation of heart rate by circulating epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003112 name: positive regulation of heart rate by neuronal epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003113 name: positive regulation of heart rate by neuronal norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003114 name: positive regulation of heart rate by circulating norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003115 name: regulation of vasoconstriction by epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003116 name: regulation of vasoconstriction by norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003117 name: regulation of vasoconstriction by circulating norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003118 name: regulation of vasoconstriction by neuronal norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003119 name: regulation of vasoconstriction by neuronal epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003120 name: regulation of vasoconstriction by circulating epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003121 name: regulation of vasodilation by epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by adrenaline" EXACT [] is_a: GO:0042312 ! regulation of vasodilation [Term] id: GO:0003122 name: regulation of vasodilation by norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by noradrenaline" EXACT [] is_a: GO:0042312 ! regulation of vasodilation [Term] id: GO:0003123 name: regulation of vasodilation by circulating epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasodilation by circulating adrenaline" EXACT [] is_a: GO:0003121 ! regulation of vasodilation by epinephrine [Term] id: GO:0003124 name: regulation of vasodilation by neuronal epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by neuronal adrenaline" EXACT [] is_a: GO:0003121 ! regulation of vasodilation by epinephrine [Term] id: GO:0003125 name: regulation of vasodilation by circulating norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasodilation by circulating noradrenaline" EXACT [] is_a: GO:0003122 ! regulation of vasodilation by norepinephrine [Term] id: GO:0003126 name: regulation of vasodilation by neuronal norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by neuronal noradrenaline" EXACT [] is_a: GO:0003122 ! regulation of vasodilation by norepinephrine [Term] id: GO:0003127 name: detection of nodal flow namespace: biological_process def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart] is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0007368 ! determination of left/right symmetry [Term] id: GO:0003128 name: heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop." [GOC:mtg_heart] is_a: GO:0010092 ! specification of organ identity relationship: part_of GO:0060914 ! heart formation [Term] id: GO:0003129 name: heart induction namespace: biological_process def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart] is_a: GO:0001759 ! organ induction relationship: positively_regulates GO:0003128 ! heart field specification [Term] id: GO:0003130 name: BMP signaling pathway involved in heart induction namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to heart induction." [GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0061312 ! BMP signaling pathway involved in heart development relationship: part_of GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0003132 name: mesodermal-endodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling involved in heart induction" EXACT [GOC:mah] is_a: GO:0003131 ! mesodermal-endodermal cell signaling is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0003134 name: endodermal-mesodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling involved in heart induction" EXACT [GOC:mah] is_a: GO:0003133 ! endodermal-mesodermal cell signaling is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003135 name: fibroblast growth factor receptor signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003136 name: negative regulation of heart induction by canonical Wnt receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329] synonym: "negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway" EXACT [GOC:dph] synonym: "negative regulation of heart induction by canonical Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009997 ! negative regulation of cardioblast cell fate specification is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development is_a: GO:0090381 ! regulation of heart induction relationship: negatively_regulates GO:0003129 ! heart induction [Term] id: GO:0003137 name: Notch signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart] synonym: "Notch signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0061314 ! Notch signaling involved in heart development relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003138 name: primary heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube." [GOC:mtg_heart] is_a: GO:0003128 ! heart field specification [Term] id: GO:0003139 name: secondary heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial and venous poles." [GOC:mtg_heart] synonym: "anterior heart field specification" NARROW [GOC:mtg_heart] synonym: "second heart field specification" EXACT [GOC:mtg_heart] is_a: GO:0003128 ! heart field specification [Term] id: GO:0003140 name: determination of left/right asymmetry in lateral mesoderm namespace: biological_process def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0048368 ! lateral mesoderm development [Term] id: GO:0003141 name: transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart] synonym: "TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] is_a: GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm [Term] id: GO:0003142 name: cardiogenic plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0035050 ! embryonic heart tube development [Term] id: GO:0003144 name: embryonic heart tube formation namespace: biological_process def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding namespace: biological_process def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation [Term] id: GO:0003146 name: heart jogging namespace: biological_process def: "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285] synonym: "cardiac jogging" EXACT [GOC:mtg_heart] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis relationship: part_of GO:0061371 ! determination of heart left/right asymmetry [Term] id: GO:0003147 name: neural crest cell migration involved in heart formation namespace: biological_process def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060974 ! cell migration involved in heart formation relationship: part_of GO:0060914 ! heart formation relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development [Term] id: GO:0003148 name: outflow tract septum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis [Term] id: GO:0003149 name: membranous septum morphogenesis namespace: biological_process def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0003150 name: muscular septum morphogenesis namespace: biological_process def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0003151 name: outflow tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding [Term] id: GO:0003153 name: closure of embryonic heart tube namespace: biological_process def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart] is_a: GO:0060606 ! tube closure relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding [Term] id: GO:0003154 name: BMP signaling pathway involved in determination of left/right symmetry namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of left/right symmetry." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:dph] synonym: "BMP signalling pathway involved in determination of left/right symmetry" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0007368 ! determination of left/right symmetry [Term] id: GO:0003155 name: BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] synonym: "BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm [Term] id: GO:0003156 name: regulation of organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0048645 ! organ formation [Term] id: GO:0003157 name: endocardium development namespace: biological_process def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003158 name: endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. An endothelium is an epithelium that lines an anatomical structure." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development [Term] id: GO:0003159 name: morphogenesis of an endothelium namespace: biological_process def: "The process in which the anatomical structure of an endothelium is generated and organized. An endothelium is an epithelium that lines an anatomical structure." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0003158 ! endothelium development [Term] id: GO:0003160 name: endocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003157 ! endocardium development [Term] id: GO:0003161 name: cardiac conduction system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] synonym: "heart conduction system development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003162 name: atrioventricular node development namespace: biological_process def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] synonym: "AV node development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003161 ! cardiac conduction system development [Term] id: GO:0003163 name: sinoatrial node development namespace: biological_process def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] synonym: "SA node development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003161 ! cardiac conduction system development [Term] id: GO:0003164 name: His-Purkinje system development namespace: biological_process def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003161 ! cardiac conduction system development [Term] id: GO:0003165 name: cardiac Purkinje fiber development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac Purkinje fiber over time, from its formation to the mature structure. The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003164 ! His-Purkinje system development [Term] id: GO:0003166 name: bundle of His development namespace: biological_process def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003164 ! His-Purkinje system development [Term] id: GO:0003167 name: atrioventricular bundle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003166 ! bundle of His development [Term] id: GO:0003168 name: cardiac Purkinje fiber cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac Purkinje fiber cell. These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003165 ! cardiac Purkinje fiber development [Term] id: GO:0003169 name: coronary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis [Term] id: GO:0003170 name: heart valve development namespace: biological_process def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart] synonym: "cardiac valve development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003171 name: atrioventricular valve development namespace: biological_process def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "AV valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003172 name: sinoatrial valve development namespace: biological_process def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "SA valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003173 name: ventriculo bulbo valve development namespace: biological_process def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003174 name: mitral valve development namespace: biological_process def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003175 name: tricuspid valve development namespace: biological_process def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003176 name: aortic valve development namespace: biological_process def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003177 name: pulmonary valve development namespace: biological_process def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003178 name: coronary sinus valve development namespace: biological_process def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003179 name: heart valve morphogenesis namespace: biological_process def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003170 ! heart valve development [Term] id: GO:0003180 name: aortic valve morphogenesis namespace: biological_process def: "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003176 ! aortic valve development [Term] id: GO:0003181 name: atrioventricular valve morphogenesis namespace: biological_process def: "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart] synonym: "AV valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003171 ! atrioventricular valve development [Term] id: GO:0003182 name: coronary sinus valve morphogenesis namespace: biological_process def: "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003178 ! coronary sinus valve development [Term] id: GO:0003183 name: mitral valve morphogenesis namespace: biological_process def: "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003174 ! mitral valve development [Term] id: GO:0003184 name: pulmonary valve morphogenesis namespace: biological_process def: "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003177 ! pulmonary valve development [Term] id: GO:0003185 name: sinoatrial valve morphogenesis namespace: biological_process def: "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart] synonym: "SA valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003172 ! sinoatrial valve development [Term] id: GO:0003186 name: tricuspid valve morphogenesis namespace: biological_process def: "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003175 ! tricuspid valve development [Term] id: GO:0003187 name: ventriculo bulbo valve morphogenesis namespace: biological_process def: "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003173 ! ventriculo bulbo valve development [Term] id: GO:0003188 name: heart valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis [Term] id: GO:0003189 name: aortic valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003180 ! aortic valve morphogenesis [Term] id: GO:0003190 name: atrioventricular valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "AV valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis [Term] id: GO:0003191 name: coronary sinus valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis [Term] id: GO:0003192 name: mitral valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003183 ! mitral valve morphogenesis [Term] id: GO:0003193 name: pulmonary valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003184 ! pulmonary valve morphogenesis [Term] id: GO:0003194 name: sinoatrial valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "SA valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis [Term] id: GO:0003195 name: tricuspid valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003186 ! tricuspid valve morphogenesis [Term] id: GO:0003196 name: ventriculo bulbo valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis [Term] id: GO:0003197 name: endocardial cushion development namespace: biological_process def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003198 name: epithelial to mesenchymal transition involved in endocardial cushion formation namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0003272 ! endocardial cushion formation [Term] id: GO:0003199 name: endocardial cushion to mesenchymal transition involved in valve formation namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0003188 ! heart valve formation [Term] id: GO:0003200 name: endocardial cushion to mesenchymal transition involved in heart chamber septation namespace: biological_process def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0060411 ! cardiac septum morphogenesis [Term] id: GO:0003201 name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0060977 ! coronary vasculature morphogenesis [Term] id: GO:0003202 name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0003204 ! cardiac skeleton development [Term] id: GO:0003203 name: endocardial cushion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003197 ! endocardial cushion development [Term] id: GO:0003204 name: cardiac skeleton development namespace: biological_process def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003205 name: cardiac chamber development namespace: biological_process def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003206 name: cardiac chamber morphogenesis namespace: biological_process def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003205 ! cardiac chamber development [Term] id: GO:0003207 name: cardiac chamber formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis [Term] id: GO:0003208 name: cardiac ventricle morphogenesis namespace: biological_process def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003231 ! cardiac ventricle development [Term] id: GO:0003209 name: cardiac atrium morphogenesis namespace: biological_process def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003230 ! cardiac atrium development [Term] id: GO:0003210 name: cardiac atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003209 ! cardiac atrium morphogenesis [Term] id: GO:0003211 name: cardiac ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis [Term] id: GO:0003212 name: cardiac left atrium morphogenesis namespace: biological_process def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis [Term] id: GO:0003213 name: cardiac right atrium morphogenesis namespace: biological_process def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis namespace: biological_process def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis namespace: biological_process def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis [Term] id: GO:0003216 name: cardiac left atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis [Term] id: GO:0003217 name: cardiac right atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis [Term] id: GO:0003218 name: cardiac left ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis [Term] id: GO:0003219 name: cardiac right ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis [Term] id: GO:0003222 name: ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis is_a: GO:0061384 ! heart trabecular morphogenesis [Term] id: GO:0003223 name: ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis [Term] id: GO:0003224 name: left ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis [Term] id: GO:0003225 name: left ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecular myocardium morphogenesis [Term] id: GO:0003226 name: right ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis [Term] id: GO:0003227 name: right ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecular myocardium morphogenesis [Term] id: GO:0003228 name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0003230 name: cardiac atrium development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003231 name: cardiac ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003232 name: bulbus arteriosus development namespace: biological_process def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003233 name: bulbus arteriosus morphogenesis namespace: biological_process def: "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003232 ! bulbus arteriosus development [Term] id: GO:0003234 name: bulbus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis [Term] id: GO:0003235 name: sinus venosus development namespace: biological_process def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003236 name: sinus venosus morphogenesis namespace: biological_process def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003235 ! sinus venosus development [Term] id: GO:0003237 name: sinus venosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003236 ! sinus venosus morphogenesis [Term] id: GO:0003238 name: conus arteriosus development namespace: biological_process def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003239 name: conus arteriosus morphogenesis namespace: biological_process def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003238 ! conus arteriosus development [Term] id: GO:0003240 name: conus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003239 ! conus arteriosus morphogenesis [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0060419 ! heart growth [Term] id: GO:0003242 name: cardiac chamber ballooning namespace: biological_process def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis [Term] id: GO:0003243 name: circumferential growth involved in left ventricle morphogenesis namespace: biological_process def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis [Term] id: GO:0003244 name: radial growth involved in right ventricle morphogenesis namespace: biological_process def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis namespace: biological_process def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis [Term] id: GO:0003246 name: embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart] synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis [Term] id: GO:0003247 name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis [Term] id: GO:0003248 name: heart capillary growth namespace: biological_process def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0060419 ! heart growth relationship: part_of GO:0060976 ! coronary vasculature development [Term] id: GO:0003249 name: cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis [Term] id: GO:0003250 name: regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis [Term] id: GO:0003251 name: positive regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis [Term] id: GO:0003252 name: negative regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis [Term] id: GO:0003253 name: cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003151 ! outflow tract morphogenesis relationship: part_of GO:0061309 ! cardiac neural crest cell development involved in outflow tract morphogenesis [Term] id: GO:0003254 name: regulation of membrane depolarization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:2000021 ! regulation of ion homeostasis relationship: regulates GO:0051899 ! membrane depolarization [Term] id: GO:0003255 name: endocardial precursor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation [Term] id: GO:0003256 name: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation [Term] id: GO:0003257 name: positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:0003256 ! regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter [Term] id: GO:0003258 name: regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0003255 ! endocardial precursor cell differentiation [Term] id: GO:0003259 name: cardioblast anterior-lateral migration namespace: biological_process def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003260 ! cardioblast migration [Term] id: GO:0003260 name: cardioblast migration namespace: biological_process def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0060974 ! cell migration involved in heart formation relationship: part_of GO:0060914 ! heart formation [Term] id: GO:0003261 name: cardiac muscle progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart] synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation [Term] id: GO:0003262 name: endocardial progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation [Term] id: GO:0003263 name: cardioblast proliferation namespace: biological_process def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0060914 ! heart formation [Term] id: GO:0003264 name: regulation of cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003156 ! regulation of organ formation is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0003263 ! cardioblast proliferation [Term] id: GO:0003265 name: regulation of primary heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the first heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "regulation of first heart field cardiac proliferation" RELATED [] is_a: GO:0003264 ! regulation of cardioblast proliferation [Term] id: GO:0003266 name: regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] is_a: GO:0003264 ! regulation of cardioblast proliferation [Term] id: GO:0003267 name: canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell resulting in an increase in the frequency, or rate of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0044340 ! canonical Wnt receptor signaling pathway involved in regulation of cell proliferation is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003268 name: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation" EXACT [GOC:dph] synonym: "fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:mah] is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003269 name: BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0061312 ! BMP signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003270 name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "Notch signaling pathway involved in regulation of second heart field cardioblast proliferation" RELATED [GOC:dph] synonym: "Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0061314 ! Notch signaling involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003271 name: smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway is_a: GO:0061311 ! cell surface receptor linked signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003272 name: endocardial cushion formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003272 ! endocardial cushion formation [Term] id: GO:0003274 name: endocardial cushion fusion namespace: biological_process def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0003203 ! endocardial cushion morphogenesis [Term] id: GO:0003275 name: apoptosis involved in outflow tract morphogenesis namespace: biological_process def: "The apoptosis process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart] is_a: GO:0003278 ! apoptosis involved in heart morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis [Term] id: GO:0003276 name: apoptosis involved in heart valve morphogenesis namespace: biological_process def: "The apoptosis process that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003278 ! apoptosis involved in heart morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis [Term] id: GO:0003277 name: apoptosis involved in endocardial cushion morphogenesis namespace: biological_process def: "The apoptosis process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0003278 ! apoptosis involved in heart morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis [Term] id: GO:0003278 name: apoptosis involved in heart morphogenesis namespace: biological_process def: "The process of apoptosis that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060561 ! apoptosis involved in morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003279 name: cardiac septum development namespace: biological_process def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] synonym: "heart septum development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003205 ! cardiac chamber development [Term] id: GO:0003281 name: ventricular septum development namespace: biological_process def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] synonym: "interventricular septum development" EXACT [GOC:mtg_heart] synonym: "septum inferius development" NARROW [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003231 ! cardiac ventricle development [Term] id: GO:0003282 name: ventricular septum intermedium development namespace: biological_process def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003281 ! ventricular septum development [Term] id: GO:0003283 name: atrial septum development namespace: biological_process def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003230 ! cardiac atrium development [Term] id: GO:0003284 name: septum primum development namespace: biological_process def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development [Term] id: GO:0003285 name: septum secundum development namespace: biological_process def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development [Term] id: GO:0003286 name: atrial septum intermedium development namespace: biological_process def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development [Term] id: GO:0003288 name: ventricular septum intermedium morphogenesis namespace: biological_process def: "The developmental process in which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0003289 name: atrial septum primum morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003284 ! septum primum development [Term] id: GO:0003290 name: atrial septum secundum morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003285 ! septum secundum development [Term] id: GO:0003291 name: atrial septum intermedium morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003286 ! atrial septum intermedium development [Term] id: GO:0003292 name: cardiac septum cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiac cell differentiation relationship: part_of GO:0003279 ! cardiac septum development [Term] id: GO:0003293 name: heart valve cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart] is_a: GO:0035051 ! cardiac cell differentiation relationship: part_of GO:0003170 ! heart valve development [Term] id: GO:0003294 name: atrial ventricular junction remodeling namespace: biological_process def: "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle." [GOC:mtg_heart] synonym: "atrio-ventricular junction remodeling " RELATED [GOC:mtg_heart] synonym: "atrioventricular junction remodeling " EXACT [GOC:mtg_heart] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003295 name: cell proliferation involved in atrial ventricular junction remodeling namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart] synonym: "cell proliferation involved in atrio-ventricular junction remodeling " EXACT [GOC:mtg_heart] synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0003294 ! atrial ventricular junction remodeling [Term] id: GO:0003296 name: apoptosis involved in atrial ventricular junction remodeling namespace: biological_process def: "The process of apoptosis that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart] synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart] synonym: "apoptosis involved in atrioventricular junction remodeling " EXACT [GOC:mtg_heart] is_a: GO:0003278 ! apoptosis involved in heart morphogenesis relationship: part_of GO:0003294 ! atrial ventricular junction remodeling [Term] id: GO:0003297 name: heart wedging namespace: biological_process def: "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003298 name: physiological muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0003299 name: muscle hypertrophy in response to stress namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart] is_a: GO:0006950 ! response to stress is_a: GO:0014896 ! muscle hypertrophy is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0003300 name: cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:mtg_heart] is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: part_of GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0003302 name: transforming growth factor beta receptor signaling pathway involved in heart jogging namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the process of heart jogging." [GOC:mtg_heart] synonym: "transforming growth factor beta receptor signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway is_a: GO:0061311 ! cell surface receptor linked signaling pathway involved in heart development relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003303 name: BMP signaling pathway involved in heart jogging namespace: biological_process def: "The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the process of heart jogging." [GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry is_a: GO:0061312 ! BMP signaling pathway involved in heart development relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003304 name: myocardial epithelial involution involved in heart jogging namespace: biological_process def: "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart] is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003305 name: cell migration involved in heart jogging namespace: biological_process def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003306 name: Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway is_a: GO:0061311 ! cell surface receptor linked signaling pathway involved in heart development [Term] id: GO:0003307 name: regulation of Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development [Term] id: GO:0003308 name: negative regulation of Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "negative regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0003307 ! regulation of Wnt receptor signaling pathway involved in heart development is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway relationship: negatively_regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development [Term] id: GO:0003309 name: type B pancreatic cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003310 name: pancreatic A cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003311 name: pancreatic D cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003312 name: pancreatic PP cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003313 name: heart rudiment development namespace: biological_process def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] synonym: "heart cone development" EXACT [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0035050 ! embryonic heart tube development [Term] id: GO:0003314 name: heart rudiment morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0003313 ! heart rudiment development [Term] id: GO:0003315 name: heart rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] synonym: "heart cone formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003314 ! heart rudiment morphogenesis [Term] id: GO:0003316 name: establishment of myocardial progenitor cell apical/basal polarity namespace: biological_process def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity relationship: part_of GO:0003315 ! heart rudiment formation [Term] id: GO:0003317 name: cardioblast cell midline fusion namespace: biological_process def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0003315 ! heart rudiment formation [Term] id: GO:0003318 name: cell migration to the midline involved in heart development namespace: biological_process def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development [Term] id: GO:0003319 name: cardioblast migration to the midline involved in heart rudiment formation namespace: biological_process def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart] is_a: GO:0003318 ! cell migration to the midline involved in heart development relationship: part_of GO:0003315 ! heart rudiment formation [Term] id: GO:0003320 name: heart rudiment involution namespace: biological_process def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart] is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation [Term] id: GO:0003321 name: positive regulation of blood pressure by epinephrine-norepinephrine namespace: biological_process def: "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph] is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine is_a: GO:0045777 ! positive regulation of blood pressure [Term] id: GO:0003322 name: pancreatic A cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] synonym: "pancreatic alpha cell development" EXACT [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003310 ! pancreatic A cell differentiation [Term] id: GO:0003323 name: type B pancreatic cell development namespace: biological_process def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell development" EXACT [GOC:mah] synonym: "pancreatic beta cell development" EXACT [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003309 ! type B pancreatic cell differentiation [Term] id: GO:0003324 name: pancreatic D cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] synonym: "pancreatic delta cell development" EXACT [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003311 ! pancreatic D cell differentiation [Term] id: GO:0003325 name: pancreatic PP cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003312 ! pancreatic PP cell differentiation [Term] id: GO:0003326 name: pancreatic A cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003310 ! pancreatic A cell differentiation [Term] id: GO:0003327 name: type B pancreatic cell fate commitment namespace: biological_process def: "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell fate commitment" EXACT [GOC:mah] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003309 ! type B pancreatic cell differentiation [Term] id: GO:0003328 name: pancreatic D cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003311 ! pancreatic D cell differentiation [Term] id: GO:0003329 name: pancreatic PP cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003312 ! pancreatic PP cell differentiation [Term] id: GO:0003330 name: regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0070278 ! extracellular matrix constituent secretion [Term] id: GO:0003331 name: positive regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion [Term] id: GO:0003332 name: negative regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion [Term] id: GO:0003333 name: amino acid transmembrane transport namespace: biological_process def: "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0006865 ! amino acid transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0003334 name: keratinocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0030216 ! keratinocyte differentiation [Term] id: GO:0003335 name: corneocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0003334 ! keratinocyte development [Term] id: GO:0003336 name: corneocyte desquamation namespace: biological_process def: "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis." [GOC:dph] synonym: "epidermal desquamation" EXACT [GOC:dph] is_a: GO:0060232 ! delamination relationship: part_of GO:0003335 ! corneocyte development [Term] id: GO:0003337 name: mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph] is_a: GO:0060231 ! mesenchymal to epithelial transition relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis [Term] id: GO:0003338 name: metanephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph] is_a: GO:0060993 ! kidney morphogenesis relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0003339 name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0072215 ! regulation of metanephros development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis [Term] id: GO:0003340 name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis [Term] id: GO:0003341 name: cilium movement namespace: biological_process def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006928 ! cellular component movement is_a: GO:0007018 ! microtubule-based movement [Term] id: GO:0003342 name: proepicardium development namespace: biological_process def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0003343 ! septum transversum development [Term] id: GO:0003343 name: septum transversum development namespace: biological_process def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development [Term] id: GO:0003344 name: pericardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060039 ! pericardium development [Term] id: GO:0003345 name: proepicardium cell migration involved in pericardium morphogenesis namespace: biological_process def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003344 ! pericardium morphogenesis [Term] id: GO:0003346 name: epicardium-derived cell migration to the myocardium namespace: biological_process def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343] is_a: GO:0060973 ! cell migration involved in heart development [Term] id: GO:0003347 name: epicardial cell to mesenchymal cell transition namespace: biological_process def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343] is_a: GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0003348 name: cardiac endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiac cell differentiation [Term] id: GO:0003349 name: epicardium-derived cardiac endothelial cell differentiation namespace: biological_process def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0003348 ! cardiac endothelial cell differentiation [Term] id: GO:0003350 name: pulmonary myocardium development namespace: biological_process def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577] is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0060841 ! venous blood vessel development [Term] id: GO:0003351 name: epithelial cilium movement namespace: biological_process def: "The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid." [GOC:dph] synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement [Term] id: GO:0003352 name: regulation of cilium movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0051270 ! regulation of cellular component movement is_a: GO:0060632 ! regulation of microtubule-based movement relationship: regulates GO:0003341 ! cilium movement [Term] id: GO:0003353 name: positive regulation of cilium movement namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051272 ! positive regulation of cellular component movement relationship: positively_regulates GO:0003341 ! cilium movement [Term] id: GO:0003354 name: negative regulation of cilium movement namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051271 ! negative regulation of cellular component movement relationship: negatively_regulates GO:0003341 ! cilium movement [Term] id: GO:0003355 name: cilium movement involved in otolith formation namespace: biological_process def: "The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles." [GOC:dph] is_a: GO:0003351 ! epithelial cilium movement relationship: part_of GO:0032475 ! otolith formation [Term] id: GO:0003356 name: regulation of cilium beat frequency namespace: biological_process def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0003352 ! regulation of cilium movement [Term] id: GO:0003357 name: noradrenergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0003358 name: noradrenergic neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] is_a: GO:0048666 ! neuron development relationship: part_of GO:0003357 ! noradrenergic neuron differentiation [Term] id: GO:0003359 name: noradrenergic neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph] synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0003357 ! noradrenergic neuron differentiation [Term] id: GO:0003360 name: brainstem development namespace: biological_process def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0003361 name: noradrenergic neuron differentiation involved in brainstem development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003357 ! noradrenergic neuron differentiation relationship: part_of GO:0003360 ! brainstem development [Term] id: GO:0003362 name: noradrenergic neuron fate commitment involved in brainstem development namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003359 ! noradrenergic neuron fate commitment relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development [Term] id: GO:0003363 name: lamellipodium assembly involved in ameboidal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030032 ! lamellipodium assembly relationship: part_of GO:0001667 ! ameboidal cell migration [Term] id: GO:0003364 name: lamellipodium assembly involved in mesendodermal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0001667 ! ameboidal cell migration [Term] id: GO:0003366 name: cell-matrix adhesion involved in ameboidal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007160 ! cell-matrix adhesion relationship: part_of GO:0001667 ! ameboidal cell migration [Term] id: GO:0003367 name: cell-cell adhesion involved in ameboidal cell migration namespace: biological_process def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration [Term] id: GO:0003368 name: cell-matrix adhesion involved in mesendodermal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration [Term] id: GO:0003369 name: establishment of cell polarity involved in mesendodermal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration [Term] id: GO:0003370 name: cell-cell adhesion involved in mesendodermal cell migration namespace: biological_process def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration is_a: GO:0070586 ! cell-cell adhesion involved in gastrulation relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration [Term] id: GO:0003372 name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration [Term] id: GO:0003373 name: dynamin polymerization involved in membrane fission namespace: biological_process def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051258 ! protein polymerization relationship: part_of GO:0090148 ! membrane fission [Term] id: GO:0003374 name: dynamin polymerization involved in mitochondrial fission namespace: biological_process def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003373 ! dynamin polymerization involved in membrane fission [Term] id: GO:0003375 name: regulation of dynamin polymerization involved in membrane fission namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032271 ! regulation of protein polymerization relationship: regulates GO:0003373 ! dynamin polymerization involved in membrane fission [Term] id: GO:0003376 name: sphingolipid signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a sphingolipid." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "sphingolipid signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction [Term] id: GO:0003377 name: regulation of apoptosis by sphingolipid signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of apoptosis by sphingolipid signalling pathway" EXACT [GOC:mah] is_a: GO:0003376 ! sphingolipid signaling pathway is_a: GO:0042981 ! regulation of apoptosis [Term] id: GO:0003378 name: regulation of inflammatory response by sphingolipid signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of inflammatory response by sphingolipid signalling pathway" EXACT [GOC:mah] is_a: GO:0003376 ! sphingolipid signaling pathway is_a: GO:0050727 ! regulation of inflammatory response [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration relationship: part_of GO:0042074 ! cell migration involved in gastrulation [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis is_a: GO:0007369 ! gastrulation [Term] id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002064 ! epithelial cell development [Term] id: GO:0003383 name: apical constriction namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0003382 ! epithelial cell morphogenesis [Term] id: GO:0003384 name: apical constriction involved in gastrulation namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003383 ! apical constriction relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation [Term] id: GO:0003385 name: cell-cell signaling involved in amphid sensory organ development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cell-cell signalling involved in amphid sensory organ development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0003386 ! amphid sensory organ development [Term] id: GO:0003386 name: amphid sensory organ development namespace: biological_process def: "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0003387 name: neuron differentiation involved in amphid sensory organ development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0003386 ! amphid sensory organ development [Term] id: GO:0003388 name: neuron development involved in amphid sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048666 ! neuron development relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development [Term] id: GO:0003389 name: retrograde extension namespace: biological_process def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031175 ! neuron projection development [Term] id: GO:0003390 name: dendrite development by retrograde extension namespace: biological_process def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003389 ! retrograde extension is_a: GO:0016358 ! dendrite development [Term] id: GO:0003391 name: amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003390 ! dendrite development by retrograde extension relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development [Term] id: GO:0003392 name: cell adhesion involved in retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007155 ! cell adhesion relationship: part_of GO:0003389 ! retrograde extension [Term] id: GO:0003393 name: neuron migration involved in retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001764 ! neuron migration relationship: part_of GO:0003389 ! retrograde extension [Term] id: GO:0003394 name: cell adhesion involved in dendrite retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003392 ! cell adhesion involved in retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension [Term] id: GO:0003395 name: neuron migration involved in dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003393 ! neuron migration involved in retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension [Term] id: GO:0003396 name: cell adhesion involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension [Term] id: GO:0003397 name: neuron migration involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension [Term] id: GO:0003398 name: glial cell differentiation involved in amphid sensory organ development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0003386 ! amphid sensory organ development [Term] id: GO:0003399 name: cytoneme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048858 ! cell projection morphogenesis [Term] id: GO:0003400 name: regulation of COPII vesicle coating namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0048209 ! regulation of vesicle targeting, to, from or within Golgi is_a: GO:0090113 ! regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis relationship: regulates GO:0048208 ! COPII vesicle coating [Term] id: GO:0003401 name: axis elongation namespace: biological_process def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis [Term] id: GO:0003402 name: planar cell polarity pathway involved in axis elongation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway relationship: part_of GO:0003401 ! axis elongation [Term] id: GO:0003403 name: optic vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0003404 name: optic vesicle morphogenesis namespace: biological_process def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis [Term] id: GO:0003405 name: optic vesicle elongation namespace: biological_process def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis [Term] id: GO:0003406 name: retinal pigment epithelium development namespace: biological_process def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0060041 ! retina development in camera-type eye [Term] id: GO:0003407 name: neural retina development namespace: biological_process def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060041 ! retina development in camera-type eye [Term] id: GO:0003408 name: optic cup formation involved in camera-type eye development namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development [Term] id: GO:0003409 name: optic cup structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development [Term] id: GO:0003410 name: anterior rotation of the optic cup namespace: biological_process def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0003412 name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis namespace: biological_process def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis [Term] id: GO:0003415 name: chondrocyte hypertrophy namespace: biological_process def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0002063 ! chondrocyte development [Term] id: GO:0003416 name: endochondral bone growth namespace: biological_process def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0003417 name: growth plate cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis relationship: part_of GO:0003416 ! endochondral bone growth [Term] id: GO:0003418 name: growth plate cartilage chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development [Term] id: GO:0003419 name: growth plate cartilage chondrocyte proliferation namespace: biological_process def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0003417 ! growth plate cartilage development [Term] id: GO:0003420 name: regulation of growth plate cartilage chondrocyte proliferation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061035 ! regulation of cartilage development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation [Term] id: GO:0003421 name: growth plate cartilage axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis [Term] id: GO:0003422 name: growth plate cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060536 ! cartilage morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development [Term] id: GO:0003423 name: growth plate cartilage chondrocyte division namespace: biological_process def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051301 ! cell division relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation [Term] id: GO:0003424 name: establishment of cell polarity involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division [Term] id: GO:0003425 name: establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000132 ! establishment of mitotic spindle orientation is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division is_a: GO:0090176 ! microtubule cytoskeleton organization involved in establishment of planar polarity [Term] id: GO:0003426 name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007010 ! cytoskeleton organization relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division [Term] id: GO:0003427 name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation is_a: GO:0051302 ! regulation of cell division is_a: GO:0051493 ! regulation of cytoskeleton organization is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway is_a: GO:2000114 ! regulation of establishment of cell polarity relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division [Term] id: GO:0003428 name: chondrocyte intercalation involved in growth plate cartilage morphogenesis namespace: biological_process def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016477 ! cell migration relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis relationship: part_of GO:0060029 ! convergent extension involved in organogenesis [Term] id: GO:0003429 name: growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation [Term] id: GO:0003430 name: growth plate cartilage chondrocyte growth namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003415 ! chondrocyte hypertrophy is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development [Term] id: GO:0003431 name: growth plate cartilage chondrocyte development namespace: biological_process def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation [Term] id: GO:0003432 name: cell growth involved in growth plate cartilage chondrocyte morphogensis namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003430 ! growth plate cartilage chondrocyte growth relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis namespace: biological_process def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis [Term] id: GO:0003434 name: BMP signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "BMP signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development [Term] id: GO:0003435 name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "hedgehog signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development [Term] id: GO:0003436 name: regulation of cell adhesion involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030155 ! regulation of cell adhesion relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis [Term] id: GO:0003437 name: regulation of cell communication involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis [Term] id: GO:0003673 name: Gene_Ontology namespace: biological_process def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. is_obsolete: true [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "molecular function" EXACT [] synonym: "molecular function unknown" NARROW [] [Term] id: GO:0003675 name: protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0003677 name: DNA binding namespace: molecular_function def: "Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] subset: goslim_candida subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003678 name: DNA helicase activity namespace: molecular_function alt_id: GO:0003679 def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] subset: gosubset_prok is_a: GO:0004386 ! helicase activity [Term] id: GO:0003680 name: AT DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564] synonym: "AT binding" EXACT [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003681 name: bent DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977] subset: gosubset_prok is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: goslim_plant synonym: "lamin/chromatin binding" BROAD [] synonym: "microtubule/chromatin interaction" RELATED [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: GO:0005488 ! binding [Term] id: GO:0003683 name: lamin/chromatin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two functions. is_obsolete: true replaced_by: GO:0003682 replaced_by: GO:0005521 [Term] id: GO:0003684 name: damaged DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] subset: gosubset_prok synonym: "DNA repair enzyme" RELATED [] synonym: "DNA repair protein" RELATED [] xref: Reactome:7372 "damaged DNA binding" is_a: GO:0003677 ! DNA binding [Term] id: GO:0003685 name: DNA repair protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. is_obsolete: true consider: GO:0003684 [Term] id: GO:0003686 name: DNA repair enzyme namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. is_obsolete: true consider: GO:0003684 [Term] id: GO:0003687 name: DNA replication factor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. is_obsolete: true consider: GO:0006260 [Term] id: GO:0003688 name: DNA replication origin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators] subset: gosubset_prok synonym: "ARS binding" NARROW [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003689 name: DNA clamp loader activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778] subset: gosubset_prok synonym: "DNA clamp loading ATPase activity" EXACT [] synonym: "PCNA loading activity" NARROW [] synonym: "PCNA loading complex activity" NARROW [] xref: Reactome:9823 "DNA clamp loader activity" is_a: GO:0003677 ! DNA binding is_a: GO:0033170 ! protein-DNA loading ATPase activity [Term] id: GO:0003690 name: double-stranded DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh] subset: gosubset_prok synonym: "dsDNA binding" EXACT [GOC:elh] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003691 name: double-stranded telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] is_a: GO:0003690 ! double-stranded DNA binding is_a: GO:0042162 ! telomeric DNA binding [Term] id: GO:0003692 name: left-handed Z-DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003693 name: P-element binding namespace: molecular_function def: "Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003694 name: plasmid binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it refers to component information. synonym: "plasmid-associated protein" RELATED [] is_obsolete: true consider: GO:0003677 consider: GO:0005727 [Term] id: GO:0003695 name: random coil DNA binding namespace: molecular_function alt_id: GO:0016017 def: "Interacting selectively and non-covalently with DNA in a random coil configuration." [GOC:mah] synonym: "random coil binding" EXACT [] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003696 name: satellite DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003697 name: single-stranded DNA binding namespace: molecular_function alt_id: GO:0003698 alt_id: GO:0003699 def: "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh] comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA. subset: gosubset_prok synonym: "ssDNA binding" EXACT [GOC:mah] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003700 name: sequence-specific DNA binding transcription factor activity namespace: molecular_function alt_id: GO:0000130 def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] subset: goslim_plant subset: gosubset_prok xref: Reactome:4325 "sequence-specific DNA binding transcription factor activity" is_a: GO:0001071 ! nucleic acid binding transcription factor activity [Term] id: GO:0003701 name: RNA polymerase I transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0001082 consider: GO:0001167 consider: GO:0006360 [Term] id: GO:0003702 name: RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0000981 consider: GO:0000991 consider: GO:0001076 consider: GO:0006366 [Term] id: GO:0003704 name: specific RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma] comment: To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0000981 consider: GO:0000991 consider: GO:0001076 consider: GO:0006366 [Term] id: GO:0003705 name: sequence-specific enhancer binding RNA polymerase II transcription factor activity namespace: molecular_function def: "Functions to initiate or regulate RNA polymerase II transcription by binding an enhancer region of DNA." [GOC:jl, GOC:txnOH] is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0003706 name: ligand-regulated transcription factor activity namespace: molecular_function def: "Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand." [GOC:curators] is_a: GO:0003674 ! molecular_function [Term] id: GO:0003707 name: steroid hormone receptor activity namespace: molecular_function def: "Combining with a steroid hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0004879 ! ligand-dependent nuclear receptor activity [Term] id: GO:0003708 name: retinoic acid receptor activity namespace: molecular_function def: "Combining with retinoic acid to initiate a change in cell activity. Retinoic acid is one of the forms of vitamin A." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. synonym: "vitamin A receptor activity" BROAD [] is_a: GO:0004879 ! ligand-dependent nuclear receptor activity [Term] id: GO:0003709 name: RNA polymerase III transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0000995 consider: GO:0001007 consider: GO:0001034 consider: GO:0006383 [Term] id: GO:0003711 name: transcription elongation regulator activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok synonym: "transcription elongation factor activity" EXACT [] synonym: "transcriptional elongation regulator activity" EXACT [] is_obsolete: true consider: GO:0032784 [Term] id: GO:0003712 name: transcription cofactor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] subset: gosubset_prok synonym: "transcriptional co-regulator" EXACT [] synonym: "transcriptional cofactor activity" EXACT [] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0003713 name: transcription coactivator activity namespace: molecular_function def: "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] subset: gosubset_prok synonym: "transcription co-activator activity" EXACT [] is_a: GO:0003712 ! transcription cofactor activity [Term] id: GO:0003714 name: transcription corepressor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] synonym: "transcription co-repressor activity" EXACT [] is_a: GO:0003712 ! transcription cofactor activity [Term] id: GO:0003715 name: transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok synonym: "transcriptional termination factor activity" EXACT [] is_obsolete: true consider: GO:0006353 [Term] id: GO:0003716 name: RNA polymerase I transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol I transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006363 [Term] id: GO:0003717 name: RNA polymerase II transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol II transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006369 [Term] id: GO:0003718 name: RNA polymerase III transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol III transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006386 [Term] id: GO:0003719 name: transcription factor binding, cytoplasmic sequestering namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process rather than a function. is_obsolete: true replaced_by: GO:0042994 [Term] id: GO:0003720 name: telomerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc] xref: EC:2.7.7.- xref: Reactome:10567 "telomerase activity" is_a: GO:0003964 ! RNA-directed DNA polymerase activity [Term] id: GO:0003721 name: telomeric template RNA reverse transcriptase activity namespace: molecular_function def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242] synonym: "telomerase, catalyst" EXACT [] is_a: GO:0003964 ! RNA-directed DNA polymerase activity relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0003723 name: RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] subset: goslim_candida subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Reactome:1805 "RNA binding" is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003724 name: RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah] subset: gosubset_prok xref: EC:2.7.7.- xref: Reactome:7008 "RNA helicase activity" is_a: GO:0004386 ! helicase activity [Term] id: GO:0003725 name: double-stranded RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl] subset: gosubset_prok synonym: "dsRNA binding" EXACT [GOC:ecd] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003726 name: double-stranded RNA adenosine deaminase activity namespace: molecular_function alt_id: GO:0003971 def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah] subset: gosubset_prok synonym: "double-stranded RNA specific editase activity" RELATED [] xref: Reactome:10576 "double-stranded RNA adenosine deaminase activity" is_a: GO:0004000 ! adenosine deaminase activity [Term] id: GO:0003727 name: single-stranded RNA binding namespace: molecular_function alt_id: GO:0003728 def: "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl] synonym: "ssRNA binding" EXACT [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003729 name: mRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA)." [GOC:jl] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0003730 name: mRNA 3'-UTR binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] synonym: "mRNA 3' UTR binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0003731 name: mRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. is_obsolete: true consider: GO:0000339 [Term] id: GO:0003732 name: snRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. is_obsolete: true consider: GO:0000339 [Term] id: GO:0003733 name: ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. is_obsolete: true replaced_by: GO:0030529 [Term] id: GO:0003734 name: small nuclear ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "snRNP" EXACT [] is_obsolete: true replaced_by: GO:0030532 [Term] id: GO:0003735 name: structural constituent of ribosome namespace: molecular_function alt_id: GO:0003736 alt_id: GO:0003737 alt_id: GO:0003738 alt_id: GO:0003739 alt_id: GO:0003740 alt_id: GO:0003741 alt_id: GO:0003742 def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. subset: gosubset_prok synonym: "ribosomal protein" BROAD [] synonym: "ribosomal RNA" RELATED [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0003743 name: translation initiation factor activity namespace: molecular_function alt_id: GO:0003744 alt_id: GO:0003745 def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:10611 "translation initiation factor activity" is_a: GO:0008135 ! translation factor activity, nucleic acid binding [Term] id: GO:0003746 name: translation elongation factor activity namespace: molecular_function alt_id: GO:0008182 alt_id: GO:0008183 def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:10616 "translation elongation factor activity" is_a: GO:0008135 ! translation factor activity, nucleic acid binding [Term] id: GO:0003747 name: translation release factor activity namespace: molecular_function alt_id: GO:0003748 alt_id: GO:0003749 def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] subset: gosubset_prok is_a: GO:0008079 ! translation termination factor activity [Term] id: GO:0003750 name: cell cycle regulator namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a single molecular function. is_obsolete: true replaced_by: GO:0051726 [Term] id: GO:0003754 name: chaperone activity namespace: molecular_function alt_id: GO:0003757 alt_id: GO:0003758 alt_id: GO:0003760 alt_id: GO:0003761 def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684] comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003755 name: peptidyl-prolyl cis-trans isomerase activity namespace: molecular_function alt_id: GO:0004752 alt_id: GO:0042028 def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] subset: gosubset_prok synonym: "cis-trans proline isomerase activity" EXACT [] synonym: "cyclophilin activity" RELATED [EC:5.2.1.8] synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW [] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW [] synonym: "immunophilin" RELATED [] synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah] synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah] synonym: "parvulin" RELATED [] synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidyl-prolyl isomerase B reaction" RELATED [] synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8] synonym: "PPIase activity" EXACT [EC:5.2.1.8] synonym: "rotamase activity" EXACT [EC:5.2.1.8] xref: EC:5.2.1.8 xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0003756 name: protein disulfide isomerase activity namespace: molecular_function def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1] subset: gosubset_prok synonym: "protein cysteine-thiol oxidation" RELATED [] synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1] synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1] synonym: "protein disulphide isomerase activity" EXACT [] synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1] xref: EC:5.3.4.1 xref: MetaCyc:5.3.4.1-RXN is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds [Term] id: GO:0003759 name: glycoprotein-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003762 name: histone-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. synonym: "nucleosome assembly chaperone" EXACT [] is_obsolete: true consider: GO:0006333 consider: GO:0006334 consider: GO:0034728 consider: GO:0042393 consider: GO:0043486 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003763 name: chaperonin ATPase activity namespace: molecular_function alt_id: GO:0003764 alt_id: GO:0003765 alt_id: GO:0003766 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "chaperonin" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0006457 [Term] id: GO:0003767 name: co-chaperone activity namespace: molecular_function alt_id: GO:0003768 alt_id: GO:0003769 alt_id: GO:0003770 alt_id: GO:0003771 def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003772 name: co-chaperonin activity namespace: molecular_function def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003773 name: heat shock protein activity namespace: molecular_function def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. is_obsolete: true consider: GO:0006986 consider: GO:0042026 [Term] id: GO:0003774 name: motor activity namespace: molecular_function def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003775 name: axonemal motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes cellular component information. is_obsolete: true consider: GO:0003777 consider: GO:0005930 [Term] id: GO:0003776 name: muscle motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes anatomy information. is_obsolete: true replaced_by: GO:0000146 consider: GO:0006936 consider: GO:0043292 [Term] id: GO:0003777 name: microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. synonym: "axonemal motor activity" NARROW [] synonym: "dynein" BROAD [] synonym: "dynein ATPase activity" NARROW [] synonym: "kinesin" BROAD [] synonym: "kinesin motor activity" NARROW [] synonym: "kinetochore motor activity" NARROW [] xref: Reactome:10659 "microtubule motor activity" is_a: GO:0003774 ! motor activity [Term] id: GO:0003778 name: dynactin motor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex. is_obsolete: true [Term] id: GO:0003779 name: actin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] synonym: "membrane associated actin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0003780 name: actin cross-linking activity namespace: molecular_function def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jid] comment: This term was made obsolete because it represents a combination of molecular functions. is_obsolete: true replaced_by: GO:0030674 replaced_by: GO:0051015 [Term] id: GO:0003781 name: actin bundling activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0051017 [Term] id: GO:0003782 name: F-actin capping activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003783 name: barbed-end actin capping activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003784 name: barbed-end actin capping/severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes two biological processes. is_obsolete: true replaced_by: GO:0051014 replaced_by: GO:0051016 [Term] id: GO:0003785 name: actin monomer binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [GOC:ai] synonym: "G actin binding" EXACT [] is_a: GO:0003779 ! actin binding [Term] id: GO:0003786 name: actin lateral binding namespace: molecular_function def: "Interacting selectively and non-covalently with an actin filament along its length." [GOC:mah] is_a: GO:0051015 ! actin filament binding [Term] id: GO:0003787 name: actin depolymerizing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0030042 [Term] id: GO:0003788 name: actin monomer sequestering activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process, not an activity. is_obsolete: true replaced_by: GO:0042989 [Term] id: GO:0003789 name: actin filament severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0051014 [Term] id: GO:0003790 name: actin modulating activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not make sense. is_obsolete: true consider: GO:0030036 [Term] id: GO:0003791 name: membrane associated actin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0003779 consider: GO:0016020 [Term] id: GO:0003792 name: regulation of actin thin filament length activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the term belongs in the process ontology. is_obsolete: true replaced_by: GO:0030832 [Term] id: GO:0003793 name: defense/immunity protein activity namespace: molecular_function def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "defence/immunity protein activity" EXACT [] is_obsolete: true consider: GO:0006952 [Term] id: GO:0003794 name: acute-phase response protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0006953 [Term] id: GO:0003795 name: antimicrobial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0006952 [Term] id: GO:0003796 name: lysozyme activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] subset: gosubset_prok synonym: "1,4-N-acetylmuramidase activity" EXACT [] synonym: "globulin G" RELATED [EC:3.2.1.17] synonym: "globulin G1" RELATED [EC:3.2.1.17] synonym: "L-7001" RELATED [EC:3.2.1.17] synonym: "lysozyme g" RELATED [EC:3.2.1.17] synonym: "mucopeptide glucohydrolase activity" EXACT [] synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT [] synonym: "muramidase activity" EXACT [] synonym: "N,O-diacetylmuramidase activity" EXACT [] synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17] synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17] xref: EC:3.2.1.17 xref: MetaCyc:3.2.1.17-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0003797 name: antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0042742 [Term] id: GO:0003798 name: male-specific antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050831 [Term] id: GO:0003799 name: antifungal peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050832 [Term] id: GO:0003800 name: antiviral response protein activity namespace: molecular_function def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0009615 [Term] id: GO:0003801 name: blood coagulation factor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0004252 consider: GO:0007596 [Term] id: GO:0003802 name: coagulation factor VIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21] synonym: "blood coagulation factor VII activity" EXACT [] synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21] xref: EC:3.4.21.21 xref: MetaCyc:3.4.21.21-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003803 name: coagulation factor IXa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22] synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22] synonym: "activated christmas factor" RELATED [EC:3.4.21.22] synonym: "autoprothrombin II" RELATED [EC:3.4.21.22] synonym: "blood coagulation factor IX activity" EXACT [] synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22] synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22] synonym: "Christmas factor activity" EXACT [EC:3.4.21.22] xref: EC:3.4.21.22 xref: MetaCyc:3.4.21.22-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003804 name: coagulation factor Xa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6] synonym: "activated factor X" RELATED [EC:3.4.21.6] synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6] synonym: "autoprothrombin C" RELATED [EC:3.4.21.6] synonym: "blood coagulation factor X activity" EXACT [] synonym: "factor Xa" RELATED [EC:3.4.21.6] synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6] synonym: "prothrombase activity" EXACT [EC:3.4.21.6] synonym: "prothrombinase activity" EXACT [EC:3.4.21.6] synonym: "Stuart factor" RELATED [EC:3.4.21.6] synonym: "Stuart factor activity" EXACT [EC:3.4.21.6] synonym: "thrombokinase activity" EXACT [EC:3.4.21.6] synonym: "thromboplastin" RELATED [EC:3.4.21.6] xref: EC:3.4.21.6 xref: MetaCyc:3.4.21.6-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003805 name: coagulation factor XIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27] synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27] synonym: "blood coagulation factor XI activity" EXACT [] synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27] synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27] xref: EC:3.4.21.27 xref: MetaCyc:3.4.21.27-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003806 name: coagulation factor XIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38] comment: This term was made obsolete because it represents a gene product. synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38] synonym: "blood coagulation factor XII activity" EXACT [] synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38] synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38] synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38] synonym: "hageman factor activity" EXACT [EC:3.4.21.38] synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38] synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38] synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38] synonym: "prealbumin activator" RELATED [EC:3.4.21.38] synonym: "prekallikrein activator" RELATED [EC:3.4.21.38] xref: EC:3.4.21.38 xref: MetaCyc:3.4.21.38-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003807 name: plasma kallikrein activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34] comment: This term was made obsolete because it represents a gene product. synonym: "bradykininogenase" BROAD [EC:3.4.21.34] synonym: "callicrein" RELATED [EC:3.4.21.34] synonym: "depot-padutin" RELATED [EC:3.4.21.34] synonym: "dilminal D" RELATED [EC:3.4.21.34] synonym: "glumorin" RELATED [EC:3.4.21.34] synonym: "kallidinogenase" BROAD [EC:3.4.21.34] synonym: "kallikrein" RELATED [EC:3.4.21.34] synonym: "kallikrein I" RELATED [EC:3.4.21.34] synonym: "kallikrein II" RELATED [EC:3.4.21.34] synonym: "kininogenase" BROAD [EC:3.4.21.34] synonym: "kininogenin activity" RELATED [EC:3.4.21.34] synonym: "onokrein P" RELATED [EC:3.4.21.34] synonym: "padreatin" RELATED [EC:3.4.21.34] synonym: "padutin" RELATED [EC:3.4.21.34] synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34] synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34] synonym: "urinary kallikrein" RELATED [EC:3.4.21.34] synonym: "urokallikrein" RELATED [EC:3.4.21.34] xref: EC:3.4.21.34 xref: MetaCyc:3.4.21.34-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003808 name: protein C (activated) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69] synonym: "activated protein C" RELATED [EC:3.4.21.69] synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69] synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69] synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69] synonym: "GSAPC" RELATED [EC:3.4.21.69] synonym: "protein Ca" RELATED [EC:3.4.21.69] xref: EC:3.4.21.69 xref: MetaCyc:3.4.21.69-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003809 name: thrombin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5] synonym: "beta-thrombin" RELATED [EC:3.4.21.5] synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5] synonym: "E thrombin" RELATED [EC:3.4.21.5] synonym: "factor IIa" RELATED [EC:3.4.21.5] synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5] synonym: "gamma-thrombin" RELATED [EC:3.4.21.5] synonym: "thrombase activity" EXACT [EC:3.4.21.5] synonym: "thrombin-C" RELATED [EC:3.4.21.5] synonym: "thrombofort" RELATED [EC:3.4.21.5] synonym: "topical" RELATED [EC:3.4.21.5] synonym: "tropostasin" RELATED [EC:3.4.21.5] xref: EC:3.4.21.5 xref: MetaCyc:3.4.21.5-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003810 name: protein-glutamine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] subset: gosubset_prok synonym: "factor XIIIa" RELATED [EC:2.3.2.13] synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13] synonym: "fibrinoligase activity" EXACT [] synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13] synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13] synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13] synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13] synonym: "TGase activity" EXACT [] synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13] synonym: "transglutaminase activity" EXACT [] xref: EC:2.3.2.13 xref: MetaCyc:2.3.2.13-RXN xref: Reactome:11549 "protein-glutamine gamma-glutamyltransferase activity" xref: RESID:AA0124 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003811 name: complement activity namespace: molecular_function def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0006956 [Term] id: GO:0003812 name: alternative-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47] comment: This term was made obsolete because it represents a gene product. synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47] synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47] synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47] synonym: "C3 convertase activity" BROAD [EC:3.4.21.47] synonym: "C3 proactivator" RELATED [EC:3.4.21.47] synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47] synonym: "C5 convertase activity" BROAD [EC:3.4.21.47] synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47] synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47] synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47] synonym: "complement factor B activity" EXACT [EC:3.4.21.47] synonym: "CVF,Bb" RELATED [EC:3.4.21.47] synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47] synonym: "heat-labile factor" RELATED [EC:3.4.21.47] synonym: "proenzyme factor B" EXACT [] synonym: "properdin factor B activity" EXACT [EC:3.4.21.47] xref: EC:3.4.21.47 xref: MetaCyc:3.4.21.47-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003813 name: classical-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43] comment: This term was made obsolete because it represents a gene product. synonym: "C3 convertase activity" BROAD [EC:3.4.21.43] synonym: "C42" RELATED [EC:3.4.21.43] synonym: "C423" RELATED [EC:3.4.21.43] synonym: "C4b,2a" RELATED [EC:3.4.21.43] synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43] synonym: "C5 convertase activity" BROAD [EC:3.4.21.43] synonym: "complement C2 activity" BROAD [EC:3.4.21.43] synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43] synonym: "complement C42" RELATED [EC:3.4.21.43] xref: EC:3.4.21.43 xref: MetaCyc:3.4.21.43-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003815 name: complement component C1r activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1r" RELATED [EC:3.4.21.41] synonym: "C1r esterase activity" EXACT [EC:3.4.21.41] synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41] xref: EC:3.4.21.41 xref: MetaCyc:3.4.21.41-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003816 name: complement component C1s activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1s" RELATED [EC:3.4.21.42] synonym: "C1 esterase activity" EXACT [EC:3.4.21.42] synonym: "C1s esterase activity" EXACT [EC:3.4.21.42] synonym: "complement C1s" RELATED [EC:3.4.21.42] synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42] xref: EC:3.4.21.42 xref: MetaCyc:3.4.21.42-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003817 name: complement factor D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46] comment: This term was made obsolete because it represents a gene product. synonym: "adipsin" EXACT [] synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46] synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46] synonym: "factor D" RELATED [EC:3.4.21.46] synonym: "factor D (complement)" RELATED [EC:3.4.21.46] synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46] xref: EC:3.4.21.46 xref: MetaCyc:3.4.21.46-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003818 name: complement factor I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45] comment: This term was made obsolete because it represents a gene product. synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45] synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45] synonym: "C3bINA" RELATED [EC:3.4.21.45] synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4bi" RELATED [EC:3.4.21.45] synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45] synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45] synonym: "factor I" RELATED [EC:3.4.21.45] xref: EC:3.4.21.45 xref: MetaCyc:3.4.21.45-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003819 name: major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "MHC protein" EXACT [] is_obsolete: true [Term] id: GO:0003820 name: class I major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true consider: GO:0042612 [Term] id: GO:0003821 name: class II major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true consider: GO:0042613 [Term] id: GO:0003822 name: MHC-interacting protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0003823 name: antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: goslim_pir synonym: "antibody" RELATED [] synonym: "B cell receptor activity" RELATED [] synonym: "immunoglobulin" RELATED [] synonym: "opsonin activity" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0003825 name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [EC:2.4.1.15] subset: gosubset_prok synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15] synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15] synonym: "transglucosylase activity" EXACT [] synonym: "trehalose 6-phosphate synthase activity" EXACT [] synonym: "trehalose 6-phosphate synthetase activity" EXACT [] synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-phosphate synthase activity" EXACT [] synonym: "trehalose-phosphate synthetase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [] synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] xref: EC:2.4.1.15 xref: MetaCyc:TREHALOSE6PSYN-RXN xref: Reactome:11571 "alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003826 name: alpha-ketoacid dehydrogenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid." [GOC:mah] subset: gosubset_prok xref: Reactome:11574 "alpha-ketoacid dehydrogenase activity" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0003827 name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP." [EC:2.4.1.101, RHEA:11459] synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTI" RELATED [EC:2.4.1.101] synonym: "GNTI activity" EXACT [EC:2.4.1.101] synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] xref: EC:2.4.1.101 xref: KEGG:R05983 xref: MetaCyc:2.4.1.101-RXN xref: Reactome:11577 "alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity" xref: RHEA:11459 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0003828 name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R." [EC:2.4.99.8] synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8] synonym: "CMP-NeuAc:LM1(alpha2-8) sialyltranferase activity" EXACT [EC:2.4.99.8] synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8] synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "SAT-2" RELATED [EC:2.4.99.8] xref: EC:2.4.99.8 xref: MetaCyc:2.4.99.8-RXN xref: Reactome:11580 "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity" is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003829 name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102] synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] xref: EC:2.4.1.102 xref: MetaCyc:2.4.1.102-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0003830 name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] subset: gosubset_prok synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "GnTIII activity" EXACT [EC:2.4.1.144] synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144] xref: EC:2.4.1.144 xref: MetaCyc:2.4.1.144-RXN xref: Reactome:11597 "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0003831 name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38] synonym: "beta-N-acetyl-beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "GalT activity" RELATED [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38] synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38] synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] xref: EC:2.4.1.38 xref: MetaCyc:2.4.1.38-RXN xref: Reactome:11598 "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity" is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003832 name: beta-alanyl-dopamine hydrolase activity namespace: molecular_function def: "Catalysis of the conversion of beta-alanyl dopamine to dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543] synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT [] synonym: "NBAD hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0003833 name: beta-alanyl-dopamine synthase activity namespace: molecular_function def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543] synonym: "N-beta-alanyl dopamine synthetase activity" EXACT [] synonym: "NBAD transferase activity" EXACT [] is_a: GO:0016874 ! ligase activity [Term] id: GO:0003834 name: beta-carotene 15,15'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O(2) = 2 retinal." [EC:1.14.99.36, RHEA:10407] comment: Note that this function was formerly EC:1.13.11.21. synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT [] synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36] synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36] synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36] xref: EC:1.14.99.36 xref: KEGG:R00032 xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN xref: Reactome:11602 "beta-carotene 15,15'-monooxygenase activity" xref: RHEA:10407 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003835 name: beta-galactoside alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1] synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1] xref: EC:2.4.99.1 xref: MetaCyc:2.4.99.1-RXN xref: Reactome:11604 "beta-galactoside alpha-2,6-sialyltransferase activity" is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003836 name: beta-galactoside alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4] xref: EC:2.4.99.4 xref: MetaCyc:2.4.99.4-RXN xref: Reactome:11607 "beta-galactoside alpha-2,3-sialyltransferase activity" is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003837 name: beta-ureidopropionase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6] subset: gosubset_prok synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6] xref: EC:3.5.1.6 xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN xref: Reactome:11609 "beta-ureidopropionase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0003838 name: sterol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41] subset: gosubset_prok synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-sterol C-methyltransferase activity" EXACT [] synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "SMT1 activity" NARROW [EC:2.1.1.41] synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41] xref: EC:2.1.1.41 xref: MetaCyc:RXN3O-178 is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0003839 name: gamma-glutamylcyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4] synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.4] synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [EC:2.3.2.4] synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [EC:2.3.2.4] synonym: "L-glutamic cyclase activity" EXACT [EC:2.3.2.4] xref: EC:2.3.2.4 xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003840 name: gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] subset: gosubset_prok synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-GPT" RELATED [EC:2.3.2.2] synonym: "gamma-GT" RELATED [EC:2.3.2.2] synonym: "gamma-GTP" RELATED [EC:2.3.2.2] synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2] xref: EC:2.3.2.2 xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN xref: Reactome:11628 "gamma-glutamyltransferase activity" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003841 name: 1-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function alt_id: GO:0004469 def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51] subset: gosubset_prok synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "lysophosphatidate acyltransferase activity" EXACT [] synonym: "lysophosphatidic acid-acyltransferase activity" EXACT [EC:2.3.1.51] xref: EC:2.3.1.51 xref: MetaCyc:RXN-1623 xref: Reactome:11629 "1-acylglycerol-3-phosphate O-acyltransferase activity" is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0003842 name: 1-pyrroline-5-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H+." [EC:1.5.1.12] subset: gosubset_prok synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12] synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12] xref: EC:1.5.1.12 xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN xref: Reactome:11630 "1-pyrroline-5-carboxylate dehydrogenase activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0003843 name: 1,3-beta-D-glucan synthase activity namespace: molecular_function alt_id: GO:0009981 def: "Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1)." [EC:2.4.1.34] synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "beta-1,3-glucan synthase activity" EXACT [] synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "callose synthase activity" EXACT [] synonym: "callose synthetase activity" EXACT [EC:2.4.1.34] synonym: "GS-II" RELATED [EC:2.4.1.34] synonym: "paramylon synthetase" RELATED [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] xref: EC:2.4.1.34 xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003844 name: 1,4-alpha-glucan branching enzyme activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT [] synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT [] synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18] synonym: "branching enzyme activity" RELATED [EC:2.4.1.18] synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18] synonym: "enzyme Q" RELATED [EC:2.4.1.18] synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18] synonym: "plant branching enzyme" RELATED [EC:2.4.1.18] synonym: "Q-enzyme" RELATED [EC:2.4.1.18] synonym: "starch branching enzyme" RELATED [EC:2.4.1.18] xref: EC:2.4.1.18 xref: MetaCyc:GLYCOGEN-BRANCH-RXN xref: Reactome:11632 "1,4-alpha-glucan branching enzyme activity" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0003845 name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+." [EC:1.1.1.146, PMID:15761036] subset: gosubset_prok synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146] synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146] synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146] xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN xref: Reactome:11633 "11-beta-hydroxysteroid dehydrogenase activity" xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003846 name: 2-acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22] synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] xref: EC:2.3.1.22 xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0003847 name: 1-alkyl-2-acetylglycerophosphocholine esterase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] subset: gosubset_prok synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] xref: EC:3.1.1.47 xref: MetaCyc:3.1.1.47-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0003848 name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11415] subset: gosubset_prok synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3] synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "HPPK" RELATED [EC:2.7.6.3] synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3] xref: EC:2.7.6.3 xref: KEGG:R03503 xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN xref: RHEA:11415 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0003849 name: 3-deoxy-7-phosphoheptulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14720] comment: Note that this function was formerly EC:4.1.2.15. subset: gosubset_prok synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54] synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54] synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54] synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54] synonym: "DS-Co activity" RELATED [EC:2.5.1.54] synonym: "DS-Mn activity" RELATED [EC:2.5.1.54] synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54] synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54] xref: EC:2.5.1.54 xref: KEGG:R01826 xref: MetaCyc:DAHPSYN-RXN xref: Reactome:11637 "3-deoxy-7-phosphoheptulonate synthase activity" xref: RHEA:14720 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003850 name: 2-deoxyglucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68] synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68] synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68] xref: EC:3.1.3.68 xref: MetaCyc:3.1.3.68-RXN is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0003851 name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] xref: EC:2.4.1.45 xref: MetaCyc:2.4.1.45-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003852 name: 2-isopropylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+)." [EC:2.3.3.13, RHEA:21527] comment: Note that this function was formerly EC:4.1.3.12. subset: gosubset_prok synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13] synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13] synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] xref: EC:2.3.3.13 xref: KEGG:R01213 xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN xref: RHEA:21527 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003853 name: 2-methylacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12] synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12] xref: EC:1.3.99.12 xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0003854 name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+." [EC:1.1.1.145] subset: gosubset_prok synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT [] synonym: "3beta-HSDH" RELATED [EC:1.1.1.145] synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145] synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145] xref: EC:1.1.1.145 xref: MetaCyc:1.1.1.145-RXN xref: Reactome:11642 "3-beta-hydroxy-delta5-steroid dehydrogenase activity" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003855 name: 3-dehydroquinate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O." [EC:4.2.1.10, RHEA:21099] subset: gosubset_prok synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "DHQase" EXACT [EC:4.2.1.10] xref: EC:4.2.1.10 xref: KEGG:R03084 xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN xref: Reactome:11643 "3-dehydroquinate dehydratase activity" xref: RHEA:21099 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003856 name: 3-dehydroquinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21971] subset: gosubset_prok synonym: "3-dehydroquinate synthetase activity" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming)" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] synonym: "5-dehydroquinate synthase activity" EXACT [EC:4.2.3.4] synonym: "5-dehydroquinic acid synthetase activity" EXACT [EC:4.2.3.4] synonym: "dehydroquinate synthase activity" EXACT [EC:4.2.3.4] synonym: "DHQ synthase" EXACT [PMID:17586643] synonym: "DHQS" EXACT [PMID:17586643] xref: EC:4.2.3.4 xref: KEGG:R03083 xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN xref: Reactome:11644 "3-dehydroquinate synthase activity" xref: RHEA:21971 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003857 name: 3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." [EC:1.1.1.35] comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'. subset: gosubset_prok synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" NARROW [EC:1.1.1.35] synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35] synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "3-oxoacyl-thioester reductase activity" RELATED [PMID:19685079] xref: EC:1.1.1.35 xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN xref: Reactome:11645 "3-hydroxyacyl-CoA dehydrogenase activity" xref: UM-BBD_enzymeID:e0664 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003858 name: 3-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH." [EC:1.1.1.30, RHEA:20524] subset: gosubset_prok synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30] xref: EC:1.1.1.30 xref: KEGG:R01361 xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN xref: Reactome:11646 "3-hydroxybutyrate dehydrogenase activity" xref: RHEA:20524 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003859 name: 3-hydroxybutyryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O." [EC:4.2.1.55, RHEA:17852] subset: gosubset_prok synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55] synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55] synonym: "crotonase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55] xref: EC:4.2.1.55 xref: KEGG:R03027 xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN xref: RHEA:17852 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003860 name: 3-hydroxyisobutyryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4] subset: gosubset_prok synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4] xref: EC:3.1.2.4 xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN xref: Reactome:11660 "3-hydroxyisobutyryl-CoA hydrolase activity" is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003861 name: 3-isopropylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O." [EC:4.2.1.33] subset: gosubset_prok synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33] synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33] synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33] synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33] synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] xref: EC:4.2.1.33 xref: MetaCyc:3-ISOPROPYLMALISOM-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003862 name: 3-isopropylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85] subset: gosubset_prok synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85] synonym: "IMDH activity" EXACT [EC:1.1.1.85] synonym: "IPMDH" RELATED [EC:1.1.1.85] synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] xref: EC:1.1.1.85 xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003863 name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4] subset: gosubset_prok synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4] synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "BCKDH activity" RELATED [EC:1.2.4.4] synonym: "BCOAD activity" RELATED [EC:1.2.4.4] synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4] synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4] xref: EC:1.2.4.4 xref: MetaCyc:1.2.4.4-RXN is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0003864 name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11] subset: gosubset_prok synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] xref: EC:2.1.2.11 xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0003865 name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5] synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5] synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5] synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5] synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5] xref: EC:1.3.99.5 xref: MetaCyc:1.3.99.5-RXN xref: Reactome:11667 "3-oxo-5-alpha-steroid 4-dehydrogenase activity" is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: GO:0003866 name: 3-phosphoshikimate 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [EC:2.5.1.19, RHEA:21259] subset: gosubset_prok synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19] synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19] xref: EC:2.5.1.19 xref: KEGG:R03460 xref: MetaCyc:2.5.1.19-RXN xref: Reactome:11668 "3-phosphoshikimate 1-carboxyvinyltransferase activity" xref: RHEA:21259 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003867 name: 4-aminobutyrate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah] subset: gosubset_prok synonym: "4-aminobutanoate transaminase activity" EXACT [] synonym: "4-aminobutyrate aminotransferase activity" EXACT [] synonym: "4-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "aminobutyrate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "beta-alanine aminotransferase" RELATED [EC:2.6.1.19] synonym: "beta-alanine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] synonym: "beta-alanine-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19] synonym: "GABA aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA transaminase activity" EXACT [] synonym: "GABA transferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid transaminase activity" EXACT [] synonym: "gamma-aminobutyric transaminase activity" EXACT [EC:2.6.1.19] synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [EC:2.6.1.19] xref: EC:2.6.1.19 xref: MetaCyc:GABATRANSAM-RXN xref: Reactome:11669 "4-aminobutyrate transaminase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003868 name: 4-hydroxyphenylpyruvate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27] subset: gosubset_prok synonym: "4-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate oxidase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic oxidase activity" EXACT [EC:1.13.11.27] xref: EC:1.13.11.27 xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN xref: Reactome:11670 "4-hydroxyphenylpyruvate dioxygenase activity" xref: UM-BBD_reactionID:r0298 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003869 name: 4-nitrophenylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate." [EC:3.1.3.41] subset: gosubset_prok synonym: "4-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "K-pNPPase activity" EXACT [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "NPPase activity" EXACT [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" EXACT [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "PNPPase activity" EXACT [EC:3.1.3.41] xref: EC:3.1.3.41 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003870 name: 5-aminolevulinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12924] subset: gosubset_prok synonym: "5-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALAS activity" EXACT [EC:2.3.1.37] synonym: "alpha-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT [EC:2.3.1.37] xref: EC:2.3.1.37 xref: KEGG:R00830 xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN xref: Reactome:11690 "5-aminolevulinate synthase activity" xref: RHEA:12924 is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0003871 name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate." [EC:2.1.1.14, RHEA:21199] subset: gosubset_prok synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "cobalamin-independent methionine synthase activity" EXACT [EC:2.1.1.14] synonym: "homocysteine methylase activity" EXACT [EC:2.1.1.14] synonym: "MetE" RELATED [EC:2.1.1.14] synonym: "methionine synthase (cobalamin-independent) activity" EXACT [EC:2.1.1.14] synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroyltriglutamate methyltransferase activity" EXACT [EC:2.1.1.14] xref: EC:2.1.1.14 xref: KEGG:R04405 xref: MetaCyc:HOMOCYSMET-RXN xref: RHEA:21199 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity [Term] id: GO:0003872 name: 6-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11] subset: gosubset_prok synonym: "6-phosphofructokinase reduction" EXACT [] synonym: "6-phosphofructose 1-kinase activity" EXACT [EC:2.7.1.11] synonym: "ATP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphate kinase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphokinase activity" EXACT [EC:2.7.1.11] synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "PFK" RELATED [EC:2.7.1.11] synonym: "phospho-1,6-fructokinase activity" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase I activity" EXACT [EC:2.7.1.11] synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11] xref: EC:2.7.1.11 xref: MetaCyc:6PFRUCTPHOS-RXN xref: Reactome:11692 "6-phosphofructokinase activity" is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0003873 name: 6-phosphofructo-2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.105, RHEA:15656] synonym: "6-phosphofructo-2-kinase (phosphorylating)" EXACT [EC:2.7.1.105] synonym: "6-phosphofructose 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "fructose 6-phosphate 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "phosphofructokinase 2 activity" EXACT [EC:2.7.1.105] xref: EC:2.7.1.105 xref: KEGG:R02732 xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN xref: Reactome:11695 "6-phosphofructo-2-kinase activity" xref: RHEA:15656 is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0003874 name: 6-pyruvoyltetrahydropterin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate." [EC:4.2.3.12, RHEA:22051] subset: gosubset_prok synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" EXACT [EC:4.2.3.12] synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" EXACT [EC:4.2.3.12] synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" EXACT [EC:4.2.3.12] synonym: "PTPS activity" EXACT [EC:4.2.3.12] xref: EC:4.2.3.12 xref: KEGG:R04286 xref: MetaCyc:4.2.3.12-RXN xref: RHEA:22051 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003875 name: ADP-ribosylarginine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19] subset: gosubset_prok synonym: "ADP-ribose-L-arginine cleavage enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADP-ribose-L-arginine cleaving enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADPribosylarginine hydrolase activity" EXACT [] synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein ADP-ribosylarginine hydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] xref: EC:3.2.2.19 xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003876 name: AMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] synonym: "5-adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-AMP deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-phosphate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenosine monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenyl deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase reaction" EXACT [] synonym: "adenylate desaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic deaminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6] xref: EC:3.5.4.6 xref: MetaCyc:AMP-DEAMINASE-RXN xref: Reactome:11698 "AMP deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0003877 name: ATP adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53] subset: gosubset_prok synonym: "adenine triphosphate adenylyltransferase activity" EXACT [EC:2.7.7.53] synonym: "ADP:ATP adenylyltransferase activity" EXACT [] synonym: "AP-4-A phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] xref: EC:2.7.7.53 xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003878 name: ATP citrate synthase activity namespace: molecular_function alt_id: GO:0046913 def: "Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21163] comment: Note that this function was formerly EC:4.1.3.8. synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8] synonym: "adenosine triphosphate citrate lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP citrate (pro-S)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citrate (pro-S)-lyase activity" EXACT [] synonym: "ATP-citrate (pro-S-)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citric lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8] synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8] synonym: "citrate-ATP lyase activity" EXACT [EC:2.3.3.8] synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8] xref: EC:2.3.3.8 xref: KEGG:R00352 xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN xref: MetaCyc:PWY-5172 xref: RHEA:21163 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003879 name: ATP phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17] subset: gosubset_prok synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.17] synonym: "adenosine triphosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP diphosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] xref: EC:2.4.2.17 xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003880 name: protein C-terminal carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein." [PMID:8428937] subset: gosubset_prok synonym: "C-terminal protein carboxyl methyltransferase activity" EXACT [] xref: EC:2.1.1.- is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0003881 name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+)." [EC:2.7.8.11, RHEA:11583] subset: gosubset_prok synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-DG:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "phosphatidylinositol synthase activity" EXACT [] xref: EC:2.7.8.11 xref: KEGG:R01802 xref: MetaCyc:2.7.8.11-RXN xref: RHEA:11583 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003882 name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8] subset: gosubset_prok synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8] synonym: "PS synthase activity" EXACT [EC:2.7.8.8] synonym: "serine exchange enzyme" BROAD [] xref: EC:2.7.8.8 xref: MetaCyc:PHOSPHASERSYN-RXN is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003883 name: CTP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] subset: gosubset_prok synonym: "CTP synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine 5'-triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "uridine triphosphate aminase activity" EXACT [EC:6.3.4.2] synonym: "UTP--ammonia ligase activity" EXACT [EC:6.3.4.2] synonym: "UTP:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.2] xref: EC:6.3.4.2 xref: MetaCyc:CTPSYN-RXN xref: Reactome:11718 "CTP synthase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0003884 name: D-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3] subset: gosubset_prok synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.3] synonym: "L-amino acid:O2 oxidoreductase activity" EXACT [EC:1.4.3.3] synonym: "new yellow enzyme" RELATED [EC:1.4.3.3] xref: EC:1.4.3.3 xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN xref: Reactome:11719 "D-amino-acid oxidase activity" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0003885 name: D-arabinono-1,4-lactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+)." [EC:1.1.3.37, RHEA:23759] subset: gosubset_prok synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" EXACT [EC:1.1.3.37] xref: EC:1.1.3.37 xref: KEGG:R02715 xref: MetaCyc:1.1.3.37-RXN xref: RHEA:23759 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003886 name: DNA (cytosine-5-)-methyltransferase activity namespace: molecular_function alt_id: GO:0008326 def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37] comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). subset: gosubset_prok synonym: "cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37] synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "cytosine-specific DNA methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA 5-cytosine methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C(5) methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine c5 methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C5 methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA-cytosine 5-methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37] synonym: "modification methylase activity" RELATED [EC:2.1.1.37] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37] synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37] synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37] xref: EC:2.1.1.37 xref: MetaCyc:2.1.1.73-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity [Term] id: GO:0003887 name: DNA-directed DNA polymerase activity namespace: molecular_function alt_id: GO:0003888 alt_id: GO:0003889 alt_id: GO:0003890 alt_id: GO:0003891 alt_id: GO:0003893 alt_id: GO:0003894 alt_id: GO:0003895 alt_id: GO:0008723 alt_id: GO:0015999 alt_id: GO:0016000 alt_id: GO:0016448 alt_id: GO:0016449 alt_id: GO:0016450 alt_id: GO:0016451 alt_id: GO:0016452 alt_id: GO:0019984 def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684] subset: gosubset_prok synonym: "alpha DNA polymerase activity" NARROW [] synonym: "beta DNA polymerase activity" NARROW [] synonym: "delta DNA polymerase activity" NARROW [] synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7] synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7] synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7] synonym: "DNA polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA polymerase II" NARROW [EC:2.7.7.7] synonym: "DNA polymerase III" NARROW [EC:2.7.7.7] synonym: "DNA polymerase V activity" NARROW [] synonym: "DNA replicase activity" EXACT [EC:2.7.7.7] synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7] synonym: "duplicase" BROAD [EC:2.7.7.7] synonym: "epsilon DNA polymerase activity" NARROW [] synonym: "eta DNA polymerase activity" NARROW [] synonym: "gamma DNA-directed DNA polymerase activity" NARROW [] synonym: "iota DNA polymerase activity" NARROW [] synonym: "kappa DNA polymerase activity" NARROW [] synonym: "Klenow fragment" NARROW [EC:2.7.7.7] synonym: "lambda DNA polymerase activity" NARROW [] synonym: "mu DNA polymerase activity" NARROW [] synonym: "nu DNA polymerase activity" NARROW [] synonym: "sequenase" RELATED [EC:2.7.7.7] synonym: "sigma DNA polymerase activity" NARROW [] synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7] synonym: "Taq Pol I" NARROW [EC:2.7.7.7] synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7] synonym: "theta DNA polymerase activity" NARROW [] synonym: "zeta DNA polymerase activity" NARROW [] xref: EC:2.7.7.7 xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:11722 "DNA-directed DNA polymerase activity" is_a: GO:0034061 ! DNA polymerase activity [Term] id: GO:0003892 name: proliferating cell nuclear antigen namespace: molecular_function alt_id: GO:0005661 def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387] comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "PCNA" EXACT [] is_obsolete: true [Term] id: GO:0003896 name: DNA primase activity namespace: molecular_function alt_id: GO:0003897 alt_id: GO:0003898 def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094] subset: gosubset_prok xref: EC:2.7.7.- is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0003899 name: DNA-directed RNA polymerase activity namespace: molecular_function alt_id: GO:0000129 def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] subset: gosubset_prok synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-directed RNA polymerase I activity" NARROW [] synonym: "DNA-directed RNA polymerase II activity" NARROW [] synonym: "DNA-directed RNA polymerase III activity" NARROW [] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: EC:2.7.7.6 xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:11745 "DNA-directed RNA polymerase activity" is_a: GO:0034062 ! RNA polymerase activity [Term] id: GO:0003900 name: DNA-directed RNA polymerase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'. is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003901 name: DNA-directed RNA polymerase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'. is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003902 name: DNA-directed RNA polymerase III activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'. is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003904 name: deoxyribodipyrimidine photo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3] subset: gosubset_prok synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribodipyrimidine photolyase activity" EXACT [] synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic photolyase activity" EXACT [EC:4.1.99.3] synonym: "dipyrimidine photolyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "DNA cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3] synonym: "photolyase activity" EXACT [EC:4.1.99.3] synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3] synonym: "phr A photolyase activity" EXACT [EC:4.1.99.3] synonym: "PhrB photolyase activity" EXACT [EC:4.1.99.3] synonym: "PRE" RELATED [EC:4.1.99.3] xref: EC:4.1.99.3 xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003905 name: alkylbase DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0004036 def: "Catalysis of the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine. Enzymes with this activity recognize and remove alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] subset: gosubset_prok synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21] synonym: "AlkA" RELATED [EC:3.2.2.21] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21] synonym: "alkylbase DNA glycosidase activity" EXACT [] synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21] synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21] synonym: "DNA-3-methyladenine glycosidase II activity" EXACT [] synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21] xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0003906 name: DNA-(apurinic or apyrimidinic site) lyase activity namespace: molecular_function def: "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18] subset: gosubset_prok synonym: "AP endonuclease class I activity" NARROW [EC:4.2.99.18] synonym: "AP lyase activity" EXACT [EC:4.2.99.18] synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] synonym: "E. coli endonuclease III" RELATED [EC:4.2.99.18] synonym: "E. coli endonuclease III activity" NARROW [EC:4.2.99.18] synonym: "endodeoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] synonym: "endonuclease VIII activity" RELATED [] synonym: "micrococcus luteus UV endonuclease" NARROW [EC:4.2.99.18] synonym: "Micrococcus luteus UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "Phage-T(4) UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "phage-T4 UV endonuclease" BROAD [EC:4.2.99.18] synonym: "Phage-T4 UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "X-ray endonuclease III" RELATED [EC:4.2.99.18] xref: EC:4.2.99.18 xref: MetaCyc:4.2.99.18-RXN xref: Reactome:12450 "DNA-(apurinic or apyrimidinic site) lyase activity" is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0003908 name: methylated-DNA-[protein]-cysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] subset: gosubset_prok synonym: "6-O-methylguanine-DNA methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT [] synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "MGMT" EXACT [] synonym: "O-6-methylguanine-DNA-alkyltransferase activity" EXACT [EC:2.1.1.63] synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD [] xref: EC:2.1.1.63 xref: MetaCyc:2.1.1.63-RXN xref: Reactome:12455 "methylated-DNA-[protein]-cysteine S-methyltransferase activity" is_a: GO:0008172 ! S-methyltransferase activity [Term] id: GO:0003909 name: DNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094] subset: gosubset_prok xref: EC:6.5.1.- xref: Reactome:12459 "DNA ligase activity" is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds [Term] id: GO:0003910 name: DNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1] subset: gosubset_prok synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1] synonym: "DNA joinase activity" BROAD [EC:6.5.1.1] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.1] synonym: "polydeoxyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1] synonym: "polynucleotide ligase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "sealase activity" RELATED [EC:6.5.1.1] xref: EC:6.5.1.1 xref: MetaCyc:DNA-LIGASE-ATP-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003911 name: DNA ligase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2] subset: gosubset_prok synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2] synonym: "DNA joinase activity" BROAD [EC:6.5.1.2] synonym: "DNA ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" EXACT [EC:6.5.1.2] synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD)" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase activity" EXACT [EC:6.5.1.2] xref: EC:6.5.1.2 xref: MetaCyc:DNA-LIGASE-NAD+-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003912 name: DNA nucleotidylexotransferase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31] synonym: "addase activity" EXACT [EC:2.7.7.31] synonym: "deoxynucleotidyl terminal transferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic acid nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [EC:2.7.7.31] synonym: "TdT" RELATED [EC:2.7.7.31] synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31] synonym: "terminal deoxynucleotide transferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxynucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxyribonucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal transferase activity" EXACT [EC:2.7.7.31] xref: EC:2.7.7.31 xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0003913 name: DNA photolyase activity namespace: molecular_function def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949] subset: gosubset_prok xref: EC:4.1.99.- xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0003914 name: DNA (6-4) photolyase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949] xref: EC:4.1.99.13 xref: MetaCyc:RXN-10771 is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003916 name: DNA topoisomerase activity namespace: molecular_function alt_id: GO:0009387 def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] subset: gosubset_prok xref: EC:5.99.1.- xref: MetaCyc:5.99.1.2-RXN is_a: GO:0003677 ! DNA binding is_a: GO:0016853 ! isomerase activity [Term] id: GO:0003917 name: DNA topoisomerase type I activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. subset: gosubset_prok synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.2] synonym: "DNA topoisomerase I activity" NARROW [] synonym: "nicking-closing enzyme activity" RELATED [EC:5.99.1.2] synonym: "omega-protein activity" RELATED [EC:5.99.1.2] synonym: "relaxing enzyme activity" RELATED [EC:5.99.1.2] synonym: "swivelase activity" RELATED [EC:5.99.1.2] synonym: "topoisomerase" BROAD [EC:5.99.1.2] synonym: "type I DNA topoisomerase activity" EXACT [] synonym: "type I topoisomerase activity" EXACT [] synonym: "untwisting enzyme activity" RELATED [EC:5.99.1.2] xref: EC:5.99.1.2 xref: MetaCyc:5.99.1.2-RXN is_a: GO:0003916 ! DNA topoisomerase activity [Term] id: GO:0003918 name: DNA topoisomerase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192] subset: gosubset_prok synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.3] synonym: "deoxyribonucleic topoisomerase activity" EXACT [EC:5.99.1.3] synonym: "DNA gyrase activity" EXACT [] synonym: "DNA topoisomerase (ATP-hydrolysing)" BROAD [EC:5.99.1.3] synonym: "DNA topoisomerase II" RELATED [EC:5.99.1.3] synonym: "DNA topoisomerase IV activity" EXACT [] synonym: "DNA topoisomerase type II activity" EXACT [] synonym: "DNA-gyrase activity" EXACT [EC:5.99.1.3] synonym: "topoisomerase" BROAD [EC:5.99.1.3] synonym: "topoisomerase II" EXACT [] synonym: "type II DNA topoisomerase activity" EXACT [EC:5.99.1.3] xref: EC:5.99.1.3 xref: MetaCyc:5.99.1.3-RXN xref: Wikipedia:Type_II_topoisomerase is_a: GO:0003916 ! DNA topoisomerase activity [Term] id: GO:0003919 name: FMN adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2, RHEA:17240] subset: gosubset_prok synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "ATP:FMN adenylyltransferase activity" EXACT [] synonym: "FAD diphosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD synthetase activity" EXACT [EC:2.7.7.2] synonym: "flavin adenine dinucleotide synthetase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] xref: EC:2.7.7.2 xref: KEGG:R00161 xref: MetaCyc:FADSYN-RXN xref: Reactome:12494 "FMN adenylyltransferase activity" xref: RHEA:17240 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003920 name: GMP reductase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17188] comment: Note that this function was formerly EC:1.6.6.8. subset: gosubset_prok synonym: "guanosine 5'-monophosphate oxidoreductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-phosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7] synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" EXACT [EC:1.7.1.7] synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" EXACT [EC:1.7.1.7] synonym: "NADPH:GMP oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] xref: EC:1.7.1.7 xref: KEGG:R01134 xref: MetaCyc:GMP-REDUCT-RXN xref: Reactome:12504 "GMP reductase activity" xref: RHEA:17188 is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0003921 name: GMP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP." [EC:6.3.4.1] synonym: "guanylate synthetase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine 5'-monophosphate aminase activity" EXACT [EC:6.3.4.1] synonym: "Xanthosine-5'-phosphate--ammonia ligase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine-5'-phosphate-ammonia ligase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine-5'-phosphate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.4.1] synonym: "XMP aminase activity" EXACT [EC:6.3.4.1] xref: EC:6.3.4.1 xref: MetaCyc:GMP-SYN-NH3-RXN xref: Reactome:12506 "GMP synthase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0003922 name: GMP synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2] subset: gosubset_prok synonym: "glutamine amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "GMP synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.2] synonym: "guanosine 5'-monophosphate synthetase activity" EXACT [EC:6.3.5.2] synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "guanylate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "xanthosine 5'-phosphate amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.2] xref: EC:6.3.5.2 xref: MetaCyc:GMP-SYN-GLUT-RXN xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0003923 name: GPI-anchor transamidase activity namespace: molecular_function def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309 "Biochemical Pathways"] xref: EC:3.-.-.- xref: Reactome:12511 "GPI-anchor transamidase activity" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0003924 name: GTPase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] subset: gosubset_prok synonym: "ARF small monomeric GTPase activity" NARROW [] synonym: "dynamin GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] synonym: "protein-synthesizing GTPase activity" NARROW [] synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] synonym: "protein-synthesizing GTPase activity, termination" NARROW [] synonym: "Rab small monomeric GTPase activity" NARROW [] synonym: "Ran small monomeric GTPase activity" NARROW [] synonym: "Ras small monomeric GTPase activity" NARROW [] synonym: "RHEB small monomeric GTPase activity" NARROW [] synonym: "Rho small monomeric GTPase activity" NARROW [] synonym: "Sar small monomeric GTPase activity" NARROW [] synonym: "signal-recognition-particle GTPase activity" NARROW [] synonym: "small monomeric GTPase activity" NARROW [] synonym: "tubulin GTPase activity" NARROW [] xref: Reactome:12513 "GTPase activity" is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003925 name: small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." [EC:3.6.5.2, GOC:mah, ISBN:0198547684, MetaCyc:3.6.1.47-RXN] comment: This term was made obsolete because it represents a gene product and contains cellular component information. is_obsolete: true replaced_by: GO:0003924 [Term] id: GO:0003926 name: ARF small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003927 name: heterotrimeric G-protein GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase." [EC:3.6.5.1, ISBN:0198547684, MetaCyc:3.6.1.46-RXN] comment: This term was made obsolete because it represents a cellular component. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0005834 [Term] id: GO:0003928 name: RAB small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003929 name: RAN small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0006606 [Term] id: GO:0003930 name: RAS small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0001558 [Term] id: GO:0003931 name: Rho small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0007010 [Term] id: GO:0003932 name: SAR small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0046903 [Term] id: GO:0003933 name: GTP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [EC:3.5.4.16, EC:3.5.4.25, EC:3.5.4.29, GOC:curators] subset: gosubset_prok xref: EC:3.5.4.- is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003934 name: GTP cyclohydrolase I activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate + H+." [EC:3.5.4.16] subset: gosubset_prok synonym: "dihydroneopterin triphosphate synthase activity" EXACT [EC:3.5.4.16] synonym: "GTP 7,8-8,9-dihydrolase activity" EXACT [EC:3.5.4.16] synonym: "GTP 8-formylhydrolase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate 8-deformylase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate cyclohydrolase activity" EXACT [EC:3.5.4.16] xref: EC:3.5.4.16 xref: KEGG:R00424 xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003935 name: GTP cyclohydrolase II activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+)." [EC:3.5.4.25, RHEA:23707] subset: gosubset_prok synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" EXACT [EC:3.5.4.25] synonym: "GTP-8-formylhydrolase activity" EXACT [EC:3.5.4.25] synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25] xref: EC:3.5.4.25 xref: KEGG:R00425 xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN xref: RHEA:23707 is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003936 name: hydrogen-transporting two-sector ATPase activity namespace: molecular_function alt_id: GO:0004006 alt_id: GO:0008729 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-] comment: This term was made obsolete because it refers to a bifunctional gene product. synonym: "proton-transporting two-sector ATPase activity" EXACT [] is_obsolete: true consider: GO:0046933 consider: GO:0046961 [Term] id: GO:0003937 name: IMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] subset: gosubset_prok synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10] synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10] synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10] synonym: "inosinicase activity" EXACT [EC:3.5.4.10] xref: EC:3.5.4.10 xref: MetaCyc:IMPCYCLOHYDROLASE-RXN xref: Reactome:12558 "IMP cyclohydrolase activity" is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003938 name: IMP dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] subset: gosubset_prok synonym: "IMP oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "IMP:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205] synonym: "inosine 5'-monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosine-5'-phosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205] xref: EC:1.1.1.205 xref: MetaCyc:IMP-DEHYDROG-RXN xref: Reactome:12563 "IMP dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003939 name: L-iditol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols. subset: gosubset_prok synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol:NAD oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "L-iditol:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14] synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14] synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] xref: EC:1.1.1.14 xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003940 name: L-iduronidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate." [EC:3.2.1.76] synonym: "alpha-L-iduronidase activity" EXACT [EC:3.2.1.76] synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" EXACT [EC:3.2.1.76] xref: EC:3.2.1.76 xref: MetaCyc:3.2.1.76-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0003941 name: L-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17] comment: Note that this function was formerly EC:4.3.1.13. subset: gosubset_prok synonym: "L-hydroxyaminoacid dehydratase activity" BROAD [] synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17] synonym: "L-serine deaminase activity" EXACT [] synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17] synonym: "L-serine hydro-lyase (deaminating) activity" EXACT [] synonym: "serine deaminase activity" BROAD [EC:4.3.1.17] xref: EC:4.3.1.17 xref: MetaCyc:4.3.1.17-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0003942 name: N-acetyl-gamma-glutamyl-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38] subset: gosubset_prok synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38] synonym: "reductase, acetyl-gamma-glutamyl phosphate" EXACT [EC:1.2.1.38] xref: EC:1.2.1.38 xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0003943 name: N-acetylgalactosamine-4-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] subset: gosubset_prok synonym: "acetylgalactosamine 4-sulfatase activity" EXACT [EC:3.1.6.12] synonym: "arylsulfatase B" EXACT [] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12] synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT [] xref: EC:3.1.6.12 xref: MetaCyc:3.1.6.12-RXN xref: Wikipedia:Arylsulfatase_B is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0003944 name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45] synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" EXACT [EC:3.1.4.45] synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" EXACT [EC:3.1.4.45] synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45] synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45] xref: EC:3.1.4.45 xref: MetaCyc:3.1.4.45-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0003945 name: N-acetyllactosamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] subset: gosubset_prok synonym: "acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta-N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta1-4GalT" RELATED [EC:2.4.1.90] synonym: "Gal-T" RELATED [EC:2.4.1.90] synonym: "lactosamine synthase activity" EXACT [EC:2.4.1.90] synonym: "lactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90] synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetylglucosamine (beta1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "NAL synthetase activity" EXACT [EC:2.4.1.90] synonym: "UDP-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] xref: EC:2.4.1.90 xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003947 name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92] synonym: "asialo-GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GalNAc-T activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "GM2/GD2-synthase activity" EXACT [EC:2.4.1.92] synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] xref: EC:2.4.1.92 xref: MetaCyc:2.4.1.92-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0003948 name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547] subset: gosubset_prok synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylamine deaspartylase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglycosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "beta-aspartylglucosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26] synonym: "glycosylasparaginase activity" EXACT [EC:3.5.1.26] synonym: "N-aspartyl-beta-glucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] xref: EC:3.5.1.26 xref: KEGG:R03421 xref: MetaCyc:3.5.1.26-RXN xref: RHEA:11547 is_a: GO:0004067 ! asparaginase activity [Term] id: GO:0003949 name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [EC:5.3.1.16, RHEA:15472] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" EXACT [EC:5.3.1.16] synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] xref: EC:5.3.1.16 xref: KEGG:R04640 xref: MetaCyc:PRIBFAICARPISOM-RXN xref: RHEA:15472 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0003950 name: NAD+ ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] subset: gosubset_prok synonym: "ADP-ribosyltransferase (polymerizing) activity" EXACT [EC:2.4.2.30] synonym: "NAD ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [EC:2.4.2.30] synonym: "poly(adenosine diphosphate ribose) polymerase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthetase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose)polymerase activity" EXACT [EC:2.4.2.30] xref: EC:2.4.2.30 xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003951 name: NAD+ kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632] subset: gosubset_prok synonym: "ATP:NAD+ 2'-phosphotransferase activity" EXACT [EC:2.7.1.23] synonym: "DPN kinase activity" RELATED [EC:2.7.1.23] synonym: "NAD kinase activity" EXACT [] synonym: "NADK" RELATED [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase activity" EXACT [EC:2.7.1.23] xref: EC:2.7.1.23 xref: KEGG:R00104 xref: MetaCyc:NAD-KIN-RXN xref: Reactome:12598 "NAD+ kinase activity" xref: RHEA:18632 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0003952 name: NAD+ synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1] subset: gosubset_prok synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.1] synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" EXACT [EC:6.3.5.1] synonym: "DPN synthetase activity" EXACT [EC:6.3.5.1] synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "NAD synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.1] synonym: "NAD+ synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD+ synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.1] synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" EXACT [EC:6.3.5.1] xref: EC:6.3.5.1 xref: MetaCyc:NAD-SYNTH-GLN-RXN xref: Reactome:12600 "NAD+ synthase (glutamine-hydrolyzing) activity" xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0003953 name: NAD+ nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [EC:3.2.2.5] subset: gosubset_prok synonym: "ADP-ribosyl cyclase activity" RELATED [EC:3.2.2.5] synonym: "diphosphopyridine nucleosidase activity" EXACT [EC:3.2.2.5] synonym: "DPN hydrolase activity" EXACT [EC:3.2.2.5] synonym: "DPNase activity" EXACT [EC:3.2.2.5] synonym: "NAD glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "NAD hydrolase activity" EXACT [EC:3.2.2.5] synonym: "NAD nucleosidase activity" EXACT [] synonym: "NAD+ glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "NADase activity" EXACT [EC:3.2.2.5] synonym: "nicotinamide adenine dinucleotide glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "nicotinamide adenine dinucleotide nucleosidase activity" EXACT [EC:3.2.2.5] xref: EC:3.2.2.5 xref: MetaCyc:NADNUCLEOSID-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003954 name: NADH dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] subset: gosubset_prok synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3] synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3] synonym: "diaphorase activity" BROAD [EC:1.6.99.3] synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3] synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3] synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3] xref: EC:1.6.99.3 xref: MetaCyc:NADH-DEHYDROGENASE-RXN is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0003955 name: NAD(P)H dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone." [EC:1.6.5.2] subset: gosubset_prok synonym: "azoreductase activity" BROAD [EC:1.6.5.2] synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" EXACT [EC:1.6.5.2] synonym: "diaphorase activity" BROAD [EC:1.6.5.2] synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2] synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H2 dehydrogenase (quinone)" EXACT [EC:1.6.5.2] synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2] synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "NQO1" RELATED [EC:1.6.5.2] synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "QR1" RELATED [EC:1.6.5.2] synonym: "quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2] xref: EC:1.6.5.2 xref: MetaCyc:NQOR-RXN xref: UM-BBD_reactionID:r0227 is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: GO:0003956 name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31] synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT [] synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.31 xref: MetaCyc:2.4.2.31-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003957 name: NAD(P)+ transhydrogenase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf, MetaCyc:PYRNUTRANSHYDROGEN-RXN] subset: gosubset_prok synonym: "H+-thase" BROAD [EC:1.6.1.1] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT [] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH:NAD+ oxidoreductase (B-specific)" EXACT [EC:1.6.1.1] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] synonym: "non-energy-linked transhydrogenase activity" EXACT [EC:1.6.1.1] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] xref: EC:1.6.1.1 xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity [Term] id: GO:0003958 name: NADPH-hemoprotein reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] subset: gosubset_prok synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4] synonym: "CPR activity" RELATED [EC:1.6.2.4] synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4] synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4] synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4] synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-ferrihemoprotein reductase activity" EXACT [] synonym: "NADPH:cytochrome c reductase activity" EXACT [] synonym: "NADPH:cytochrome P450 reductase activity" EXACT [] synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "POR" RELATED [EC:1.6.2.4] synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4] synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4] xref: EC:1.6.2.4 xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: GO:0003959 name: NADPH dehydrogenase activity namespace: molecular_function alt_id: GO:0008468 alt_id: GO:0016660 def: "Catalysis of the reaction: NADPH + H+ + quinone acceptor = NADP+ + hydroquinone." [EC:1.6.99.1] subset: gosubset_prok synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2 diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "old yellow enzyme" RELATED [EC:1.6.99.1] synonym: "OYE" RELATED [EC:1.6.99.1] synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH-diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.1] xref: EC:1.6.99.1 xref: MetaCyc:NADPH-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0523 is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0003960 name: NADPH:quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] subset: gosubset_prok synonym: "NADPH:quinone oxidoreductase activity" EXACT [EC:1.6.5.5] synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5] synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5] xref: EC:1.6.5.5 xref: MetaCyc:QOR-RXN is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: GO:0003961 name: O-acetylhomoserine aminocarboxypropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate." [EC:2.5.1.49] comment: Note that this function was formerly EC:4.2.99.10. subset: gosubset_prok synonym: "4.2.99.9" RELATED [] synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.49] synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT [] synonym: "O-acetylhomoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "OAH sulfhydrylase activity" EXACT [EC:2.5.1.49] xref: EC:2.5.1.49 xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003962 name: cystathionine gamma-synthase activity namespace: molecular_function alt_id: GO:0000505 def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48] comment: Formerly EC 4.2.99.9. subset: gosubset_prok synonym: "CTT gamma synthase activity" EXACT [] synonym: "cystathionine g-synthase activity" EXACT [] synonym: "cystathionine gamma synthase activity" EXACT [] synonym: "cystathionine synthase activity" EXACT [EC:2.5.1.48] synonym: "cystathionine synthetase activity" EXACT [EC:2.5.1.48] synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT [] synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" EXACT [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT [] synonym: "O-succinylhomoserine (thiol)-lyase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthetase activity" EXACT [EC:2.5.1.48] synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.48] xref: EC:2.5.1.48 xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003963 name: RNA-3'-phosphate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] subset: gosubset_prok synonym: "RNA 3'-terminal phosphate cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4] xref: EC:6.5.1.4 xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN is_a: GO:0009975 ! cyclase activity is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds [Term] id: GO:0003964 name: RNA-directed DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] subset: gosubset_prok synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "DNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "reverse transcriptase activity" EXACT [EC:2.7.7.49] synonym: "revertase activity" RELATED [EC:2.7.7.49] synonym: "RNA revertase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW [] synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW [] synonym: "RNA-instructed DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RT" RELATED [EC:2.7.7.49] xref: EC:2.7.7.49 xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:10568 "RNA-directed DNA polymerase activity" is_a: GO:0034061 ! DNA polymerase activity [Term] id: GO:0003966 name: RNA-directed DNA polymerase, transposon encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003967 name: RNA-directed DNA polymerase, group II intron encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003968 name: RNA-directed RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] subset: gosubset_prok synonym: "3D polymerase activity" EXACT [EC:2.7.7.48] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [EC:2.7.7.48] synonym: "PB1 proteins" RELATED [EC:2.7.7.48] synonym: "PB2 proteins" RELATED [EC:2.7.7.48] synonym: "phage f2 replicase" NARROW [EC:2.7.7.48] synonym: "polymerase L" RELATED [EC:2.7.7.48] synonym: "Q-beta replicase activity" EXACT [EC:2.7.7.48] synonym: "RDRP" RELATED [EC:2.7.7.48] synonym: "ribonucleic acid replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.48] synonym: "RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "transcriptase" BROAD [EC:2.7.7.48] xref: EC:2.7.7.48 xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:12642 "RNA-directed RNA polymerase activity" is_a: GO:0034062 ! RNA polymerase activity [Term] id: GO:0003969 name: RNA editase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a biological process. is_obsolete: true [Term] id: GO:0003972 name: RNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)." [EC:6.5.1.3] subset: gosubset_prok synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide ligase activity" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.3] synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3] xref: EC:6.5.1.3 xref: MetaCyc:RNA-LIGASE-ATP-RXN is_a: GO:0008452 ! RNA ligase activity [Term] id: GO:0003973 name: (S)-2-hydroxy-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide." [EC:1.1.3.15] subset: gosubset_prok synonym: "(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] synonym: "hydroxyacid oxidase A" RELATED [EC:1.1.3.15] synonym: "L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15] xref: EC:1.1.3.15 xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003974 name: UDP-N-acetylglucosamine 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] subset: gosubset_prok synonym: "UDP acetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-GlcNAc 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphoacetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] xref: EC:5.1.3.7 xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003975 name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15] subset: gosubset_prok synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15] synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] xref: EC:2.7.8.15 xref: MetaCyc:2.7.8.15-RXN xref: Reactome:12669 "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity" is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003976 name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17] synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminyl phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17] synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] xref: EC:2.7.8.17 xref: MetaCyc:2.7.8.17-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003977 name: UDP-N-acetylglucosamine diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [EC:2.7.7.23, RHEA:13512] subset: gosubset_prok synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23] synonym: "GlmU uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UDP-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-GlcNAc pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] xref: EC:2.7.7.23 xref: KEGG:R00416 xref: MetaCyc:NAG1P-URIDYLTRANS-RXN xref: Reactome:12672 "UDP-N-acetylglucosamine diphosphorylase activity" xref: RHEA:13512 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0003978 name: UDP-glucose 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] subset: gosubset_prok synonym: "4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2] synonym: "UDP-D-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-glucose epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPG-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPgalactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate glucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphospho-galactose-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose epimerase activity" EXACT [EC:5.1.3.2] xref: EC:5.1.3.2 xref: MetaCyc:UDPGLUCEPIM-RXN xref: Reactome:12673 "UDP-glucose 4-epimerase activity" is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003979 name: UDP-glucose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23599] subset: gosubset_prok xref: EC:1.1.1.22 xref: KEGG:R00286 xref: MetaCyc:UGD-RXN xref: Reactome:12674 "UDP-glucose 6-dehydrogenase activity" xref: RHEA:23599 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003980 name: UDP-glucose:glycoprotein glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [PMID:10764828] synonym: "UGGT activity" EXACT [] xref: EC:2.4.1.- xref: Reactome:12706 "UDP-glucose:glycoprotein glucosyltransferase activity" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003983 name: UTP:glucose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19892] subset: gosubset_prok synonym: "glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG phosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine-diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] xref: EC:2.7.7.9 xref: KEGG:R00289 xref: MetaCyc:GLUC1PURIDYLTRANS-RXN xref: Reactome:12708 "UTP:glucose-1-phosphate uridylyltransferase activity" xref: RHEA:19892 is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0003984 name: acetolactate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [EC:2.2.1.6] comment: Note that this function was formerly EC:4.1.3.18. subset: gosubset_prok synonym: "acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "acetolactate pyruvate-lyase (carboxylating) activity" EXACT [EC:2.2.1.6] synonym: "acetolactic synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthetase activity" EXACT [EC:2.2.1.6] synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.6] xref: EC:2.2.1.6 xref: MetaCyc:ACETOLACTSYN-RXN is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0003985 name: acetyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9] subset: gosubset_prok synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9] synonym: "3-oxothiolase activity" EXACT [EC:2.3.1.9] synonym: "acetoacetyl-CoA thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:N-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "beta-acetoacetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "thiolase II" RELATED [EC:2.3.1.9] xref: EC:2.3.1.9 xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN xref: Reactome:12710 "acetyl-CoA C-acetyltransferase activity" xref: UM-BBD_enzymeID:e0144 is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0003986 name: acetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+)." [EC:3.1.2.1, RHEA:20292] subset: gosubset_prok synonym: "acetyl coenzyme A acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA thiol esterase activity" EXACT [EC:3.1.2.1] xref: EC:3.1.2.1 xref: KEGG:R00227 xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN xref: Reactome:12713 "acetyl-CoA hydrolase activity" xref: RHEA:20292 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003987 name: acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1] subset: gosubset_prok synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1] synonym: "acetate to acetyl-CoA" RELATED [] synonym: "acetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.1] synonym: "acetic thiokinase activity" EXACT [EC:6.2.1.1] synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1] synonym: "acetyl CoA ligase activity" EXACT [EC:6.2.1.1] synonym: "acetyl CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl coenzyme A synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-activating enzyme activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-coenzyme A synthase activity" EXACT [EC:6.2.1.1] synonym: "ACS" RELATED [EC:6.2.1.1] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1] synonym: "short chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "short-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.1] xref: EC:6.2.1.1 xref: MetaCyc:ACETATE--COA-LIGASE-RXN xref: Reactome:12714 "acetate-CoA ligase activity" is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003988 name: acetyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] subset: gosubset_prok synonym: "2-keto-acyl thiolase activity" EXACT [] synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16] synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl-CoA thiolase activity" EXACT [] synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "KAT" RELATED [EC:2.3.1.16] synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "thiolase I" RELATED [EC:2.3.1.16] xref: EC:2.3.1.16 xref: MetaCyc:KETOACYLCOATHIOL-RXN xref: Reactome:12715 "acetyl-CoA C-acyltransferase activity" xref: UM-BBD_reactionID:r1051 is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0003989 name: acetyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] subset: gosubset_prok synonym: "acetyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.2] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.2] xref: EC:6.4.1.2 xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN xref: Reactome:12716 "acetyl-CoA carboxylase activity" is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0003990 name: acetylcholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] subset: gosubset_prok synonym: "AcCholE" RELATED [EC:3.1.1.7] synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7] synonym: "choline esterase I activity" EXACT [EC:3.1.1.7] synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7] xref: EC:3.1.1.7 xref: MetaCyc:ACETYLCHOLINESTERASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0003991 name: acetylglutamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate." [EC:2.7.2.8] subset: gosubset_prok synonym: "acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate kinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamic 5-phosphotransferase activity" EXACT [EC:2.7.2.8] xref: EC:2.7.2.8 xref: MetaCyc:ACETYLGLUTKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0003992 name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity namespace: molecular_function alt_id: GO:0047318 def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11, RHEA:18052] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine aminotransferase activity" BROAD [] synonym: "acetylornithine delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine transaminase activity" BROAD [EC:2.6.1.11] synonym: "ACOAT activity" EXACT [EC:2.6.1.11] synonym: "N(2)-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine-delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT [] synonym: "N2-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11] xref: EC:2.6.1.11 xref: KEGG:R02283 xref: MetaCyc:ACETYLORNTRANSAM-RXN xref: RHEA:18052 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003993 name: acid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] subset: gosubset_prok synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2] synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2] synonym: "uteroferrin" RELATED [EC:3.1.3.2] xref: EC:3.1.3.2 xref: MetaCyc:ACID-PHOSPHATASE-RXN xref: Reactome:9271 "acid phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003994 name: aconitate hydratase activity namespace: molecular_function def: "Catalysis of the reactions: citrate = cis-aconitate + H2O, and cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3] comment: This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'. subset: gosubset_prok synonym: "aconitase activity" EXACT [] synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3] xref: EC:4.2.1.3 xref: Reactome:12740 "aconitate hydratase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003995 name: acyl-CoA dehydrogenase activity namespace: molecular_function alt_id: GO:0019109 def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] subset: gosubset_prok synonym: "acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA reductase activity" EXACT [GOC:mah] synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "fatty acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "fatty-acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "general acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3] synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] xref: EC:1.3.99.3 xref: MetaCyc:ACYLCOADEHYDROG-RXN xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN xref: Reactome:4266 "acyl-CoA dehydrogenase activity" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0003996 name: acyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18." [EC:6.2.1.3, GOC:mah] subset: gosubset_prok xref: EC:6.2.1.- is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003997 name: acyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6] subset: gosubset_prok synonym: "acyl coenzyme A oxidase activity" EXACT [EC:1.3.3.6] synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-CoA oxidase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-coenzyme A oxidase activity" EXACT [EC:1.3.3.6] xref: EC:1.3.3.6 xref: MetaCyc:ACYL-COA-OXIDASE-RXN xref: Reactome:12745 "acyl-CoA oxidase activity" is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0003998 name: acylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] subset: gosubset_prok synonym: "1,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetic phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetylphosphatase activity" EXACT [EC:3.6.1.7] synonym: "acylphosphate phosphohydrolase activity" EXACT [EC:3.6.1.7] synonym: "GP 1-3" RELATED [EC:3.6.1.7] synonym: "Ho 1-3" RELATED [EC:3.6.1.7] xref: EC:3.6.1.7 xref: MetaCyc:ACYLPHOSPHATASE-RXN is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0003999 name: adenine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7] subset: gosubset_prok synonym: "adenine phosphoribosylpyrophosphate transferase activity" EXACT [EC:2.4.2.7] synonym: "adenosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "adenylate pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "adenylic pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP diphosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "APRT activity" EXACT [EC:2.4.2.7] synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7] xref: EC:2.4.2.7 xref: MetaCyc:ADENPRIBOSYLTRAN-RXN xref: Reactome:12749 "adenine phosphoribosyltransferase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004000 name: adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] subset: gosubset_prok synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4] synonym: "adenosine deaminase reaction" EXACT [] xref: EC:3.5.4.4 xref: MetaCyc:ADENODEAMIN-RXN xref: Reactome:6985 "adenosine deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004001 name: adenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] subset: gosubset_prok synonym: "adenosine 5-phosphotransferase activity" EXACT [] synonym: "adenosine kinase (phosphorylating)" EXACT [EC:2.7.1.20] synonym: "ATP:adenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.20] xref: EC:2.7.1.20 xref: MetaCyc:ADENOSINE-KINASE-RXN xref: Reactome:6989 "adenosine kinase activity" is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0004003 name: ATP-dependent DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok is_a: GO:0003678 ! DNA helicase activity is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0004004 name: ATP-dependent RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok is_a: GO:0003724 ! RNA helicase activity is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008186 ! RNA-dependent ATPase activity [Term] id: GO:0004005 name: plasma membrane cation-transporting ATPase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0005886 consider: GO:0019829 [Term] id: GO:0004007 name: heavy metal-exporting ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0046873 [Term] id: GO:0004008 name: copper-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)." [EC:3.6.3.4] subset: gosubset_prok synonym: "ATP phosphohydrolase (Cu2+-exporting)" EXACT [EC:3.6.3.4] synonym: "copper exporting ATPase activity" EXACT [] synonym: "copper-translocating P-type ATPase activity" RELATED [EC:3.6.3.4] synonym: "Cu(2+)-exporting ATPase activity" EXACT [EC:3.6.3.4] synonym: "Cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] synonym: "cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] xref: EC:3.6.3.4 xref: MetaCyc:3.6.3.4-RXN xref: Reactome:7024 "copper-exporting ATPase activity" xref: RHEA:10379 is_a: GO:0043682 ! copper-transporting ATPase activity [Term] id: GO:0004009 name: ATP-binding cassette (ABC) transporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0004012 name: phospholipid-translocating ATPase activity namespace: molecular_function alt_id: GO:0008557 def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684] subset: gosubset_prok synonym: "aminophospholipid-transporting ATPase" NARROW [] synonym: "ATP phosphohydrolase (phospholipid-flipping)" EXACT [EC:3.6.3.1] synonym: "flippase activity" BROAD [EC:3.6.3.1] synonym: "magnesium-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg(2+)-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg2+-ATPase activity" EXACT [EC:3.6.3.1] synonym: "phospholipid translocating ATPase activity" EXACT [] synonym: "phospholipid-transporting ATPase activity" EXACT [EC:3.6.3.1] xref: EC:3.6.3.1 xref: MetaCyc:3.6.3.1-RXN xref: Reactome:7036 "phospholipid-translocating ATPase activity" is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0043492 ! ATPase activity, coupled to movement of substances [Term] id: GO:0004013 name: adenosylhomocysteinase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] subset: gosubset_prok synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1] synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1] synonym: "SAHase activity" EXACT [EC:3.3.1.1] xref: EC:3.3.1.1 xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN xref: Reactome:7047 "adenosylhomocysteinase activity" is_a: GO:0016802 ! trialkylsulfonium hydrolase activity [Term] id: GO:0004014 name: adenosylmethionine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [EC:4.1.1.50, RHEA:15984] subset: gosubset_prok synonym: "adenosyl methionine decarboxylase activity" EXACT [] synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine decarboxylase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosylmethionine decarboxylase activity" EXACT [EC:4.1.1.50] xref: EC:4.1.1.50 xref: KEGG:R00178 xref: MetaCyc:SAMDECARB-RXN xref: Reactome:7049 "adenosylmethionine decarboxylase activity" xref: RHEA:15984 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004015 name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16864] subset: gosubset_prok synonym: "7,8-diamino-pelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminonanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT [] synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT [] synonym: "DAPA aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "DAPA transaminase activity" EXACT [EC:2.6.1.62] synonym: "diaminopelargonate synthase activity" EXACT [EC:2.6.1.62] synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] xref: EC:2.6.1.62 xref: KEGG:R03231 xref: MetaCyc:DAPASYN-RXN xref: RHEA:16864 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004016 name: adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] subset: gosubset_prok synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1] synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1] synonym: "adenylyl cyclase activity" EXACT [] synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1] synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1] synonym: "cAMP generating peptide activity" RELATED [] xref: EC:4.6.1.1 xref: MetaCyc:ADENYLATECYC-RXN xref: Reactome:7056 "adenylate cyclase activity" is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004017 name: adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] subset: gosubset_prok synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylokinase activity" EXACT [EC:2.7.4.3] synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3] synonym: "myokinase activity" NARROW [EC:2.7.4.3] xref: EC:2.7.4.3 xref: MetaCyc:ADENYL-KIN-RXN xref: Reactome:7059 "adenylate kinase activity" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004018 name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] subset: gosubset_prok synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah] synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah] synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] xref: EC:4.3.2.2 xref: KEGG:R01083 xref: MetaCyc:AMPSYN-RXN xref: Reactome:7065 "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity" is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004019 name: adenylosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [EC:6.3.4.4, RHEA:15756] subset: gosubset_prok synonym: "adenylosuccinate synthetase activity" EXACT [EC:6.3.4.4] synonym: "IMP--aspartate ligase activity" EXACT [EC:6.3.4.4] synonym: "IMP:L-aspartate ligase (GDP-forming)" EXACT [EC:6.3.4.4] synonym: "succino-AMP synthetase activity" EXACT [EC:6.3.4.4] synonym: "succinoadenylic kinosynthetase activity" EXACT [EC:6.3.4.4] xref: EC:6.3.4.4 xref: KEGG:R01135 xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN xref: Reactome:7069 "adenylosuccinate synthase activity" xref: RHEA:15756 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004020 name: adenylylsulfate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25] subset: gosubset_prok synonym: "5'-phosphoadenosine sulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine 5'-phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT [] synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT [] synonym: "adenylyl-sulfate kinase activity" EXACT [] synonym: "adenylyl-sulphate kinase activity" EXACT [] synonym: "adenylylsulfate kinase (phosphorylating)" EXACT [EC:2.7.1.25] synonym: "APS kinase activity" EXACT [EC:2.7.1.25] synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" EXACT [EC:2.7.1.25] xref: EC:2.7.1.25 xref: MetaCyc:ADENYLYLSULFKIN-RXN xref: Reactome:7077 "adenylylsulfate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004021 name: L-alanine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19456] subset: gosubset_prok synonym: "alanine aminotransferase activity" BROAD [] synonym: "alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "alanine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "ALT" RELATED [EC:2.6.1.2] synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2] synonym: "glutamic acid-pyruvic acid transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--alanine transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--pyruvic transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic-pyruvic aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "GPT" RELATED [EC:2.6.1.2] synonym: "L-alanine aminotransferase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate transaminase activity" BROAD [EC:2.6.1.2] synonym: "pyruvate-alanine aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2] xref: EC:2.6.1.2 xref: KEGG:R00258 xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN xref: Reactome:7079 "L-alanine:2-oxoglutarate aminotransferase activity" xref: RHEA:19456 is_a: GO:0047635 ! alanine-oxo-acid transaminase activity [Term] id: GO:0004022 name: alcohol dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] subset: gosubset_prok synonym: "ADH" RELATED [EC:1.1.1.1] synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah] synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1] synonym: "aldehyde dehydrogenase (NAD) activity" NARROW [] synonym: "aldo-keto reductase (NAD) activity" EXACT [] synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1] synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] xref: EC:1.1.1.1 xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN xref: UM-BBD_enzymeID:e0023 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004023 name: alcohol dehydrogenase activity, metal ion-independent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah] is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004024 name: alcohol dehydrogenase activity, zinc-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc." [EC:1.1.1.1, GOC:mah] subset: gosubset_prok xref: Reactome:7085 "alcohol dehydrogenase activity, zinc-dependent" is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004025 name: alcohol dehydrogenase activity, iron-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah] subset: gosubset_prok is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004026 name: alcohol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84] synonym: "AATASE activity" EXACT [EC:2.3.1.84] synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84] synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84] xref: EC:2.3.1.84 xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity [Term] id: GO:0004027 name: alcohol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] subset: gosubset_prok synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "alcohol sulphotransferase activity" EXACT [] synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] synonym: "HST" RELATED [EC:2.8.2.2] synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2] xref: EC:2.8.2.2 xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN xref: Reactome:7092 "alcohol sulfotransferase activity" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004028 name: 3-chloroallyl aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432] subset: gosubset_prok xref: EC:1.2.1.- xref: Reactome:7095 "3-chloroallyl aldehyde dehydrogenase activity" xref: UM-BBD_enzymeID:e0432 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004029 name: aldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3] subset: gosubset_prok synonym: "aldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.3] synonym: "aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.3] synonym: "CoA-independent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "m-methylbenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-linked aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "propionaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] xref: EC:1.2.1.3 xref: MetaCyc:ALDHDEHYDROG-RXN xref: Reactome:7097 "aldehyde dehydrogenase (NAD) activity" xref: UM-BBD_enzymeID:e0024 xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+) is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004030 name: aldehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5] subset: gosubset_prok synonym: "aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.5] synonym: "ALDH" RELATED [EC:1.2.1.5] xref: EC:1.2.1.5 xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004031 name: aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide." [EC:1.2.3.1] subset: gosubset_prok synonym: "aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.1] synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1] xref: EC:1.2.3.1 xref: MetaCyc:ALDEHYDE-OXIDASE-RXN is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0004032 name: alditol:NADP+ 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] subset: gosubset_prok synonym: "aldose reductase activity" EXACT [EC:1.1.1.21] synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21] xref: EC:1.1.1.21 xref: KEGG:\:R02820 "alditol:NADP+ 1-oxidoreductase" xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN xref: Reactome:7111 "aldehyde reductase activity" is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] id: GO:0004033 name: aldo-keto reductase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [GOC:ai] subset: gosubset_prok synonym: "alcohol dehydrogenase (NADP+) activity" NARROW [] synonym: "aldo-keto reductase (NADP+) activity" EXACT [] synonym: "aldo-keto reductase activity" EXACT [] synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw] xref: EC:1.1.1.- xref: Reactome:7114 "aldo-keto reductase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004034 name: aldose 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3] subset: gosubset_prok synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3] synonym: "mutarotase activity" RELATED [EC:5.1.3.3] xref: EC:5.1.3.3 xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0004035 name: alkaline phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] subset: gosubset_prok synonym: "alkaline phenyl phosphatase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphohydrolase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphomonoesterase activity" EXACT [EC:3.1.3.1] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1] synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1] xref: EC:3.1.3.1 xref: MetaCyc:ALKAPHOSPHA-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004037 name: allantoicase activity namespace: molecular_function def: "Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11019] subset: gosubset_prok synonym: "allantoate amidinohydrolase activity" EXACT [EC:3.5.3.4] synonym: "allantoine amidinohydrolase activity" EXACT [] xref: EC:3.5.3.4 xref: KEGG:R02422 xref: MetaCyc:ALLANTOICASE-RXN xref: RHEA:11019 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004038 name: allantoinase activity namespace: molecular_function def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5] subset: gosubset_prok synonym: "(S)-allantoin amidohydrolase activity" EXACT [EC:3.5.2.5] xref: EC:3.5.2.5 xref: MetaCyc:ALLANTOINASE-RXN is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004039 name: allophanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+)." [EC:3.5.1.54, RHEA:19032] subset: gosubset_prok synonym: "allophanate lyase activity" EXACT [EC:3.5.1.54] synonym: "urea-1-carboxylate amidohydrolase activity" EXACT [EC:3.5.1.54] xref: EC:3.5.1.54 xref: KEGG:R00005 xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN xref: RHEA:19032 xref: UM-BBD_reactionID:r0848 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004040 name: amidase activity namespace: molecular_function def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4] subset: gosubset_prok synonym: "acetamidase activity" EXACT [] synonym: "acylamidase activity" EXACT [EC:3.5.1.4] synonym: "acylamide amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "acylase activity" EXACT [EC:3.5.1.4] synonym: "amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4] synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4] xref: EC:3.5.1.4 xref: MetaCyc:AMIDASE-RXN xref: UM-BBD_enzymeID:e0068 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004042 name: acetyl-CoA:L-glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)." [EC:2.3.1.1, RHEA:24295] subset: gosubset_prok synonym: "acetylglutamate acetylglutamate synthetase activity" EXACT [EC:2.3.1.1] synonym: "AGAS" RELATED [EC:2.3.1.1] synonym: "amino acid acetyltransferase activity" EXACT [EC:2.3.1.1] synonym: "amino-acid N-acetyltransferase activity" BROAD [EC:2.3.1.1] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1] xref: EC:2.3.1.1 xref: KEGG:R00259 xref: MetaCyc:N-ACETYLTRANSFER-RXN xref: Reactome:7143 "acetyl-CoA:L-glutamate N-acetyltransferase activity" xref: RHEA:24295 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004043 name: L-aminoadipate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] subset: gosubset_prok synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "AAR" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31] xref: EC:1.2.1.31 xref: MetaCyc:1.2.1.31-RXN xref: Reactome:7145 "L-aminoadipate-semialdehyde dehydrogenase activity" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004044 name: amidophosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14908] subset: gosubset_prok synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" EXACT [EC:2.4.2.14] synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribose pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyl pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" EXACT [EC:2.4.2.14] xref: EC:2.4.2.14 xref: KEGG:R01072 xref: MetaCyc:PRPPAMIDOTRANS-RXN xref: Reactome:7147 "amidophosphoribosyltransferase activity" xref: RHEA:14908 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004045 name: aminoacyl-tRNA hydrolase activity namespace: molecular_function alt_id: GO:0019850 alt_id: GO:0019851 def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29] subset: gosubset_prok synonym: "aminoacyl-transfer ribonucleate hydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA aminoacylhydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] synonym: "D-tyrosyl-tRNA hydrolase activity" NARROW [PMID:15292242] synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1.1.29] synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29] xref: EC:3.1.1.29 xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004046 name: aminoacylase activity namespace: molecular_function def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] subset: gosubset_prok synonym: "acylase I activity" NARROW [EC:3.5.1.14] synonym: "alpha-N-acylaminoacid hydrolase activity" EXACT [EC:3.5.1.14] synonym: "amido acid deacylase activity" EXACT [EC:3.5.1.14] synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14] synonym: "benzamidase activity" RELATED [EC:3.5.1.14] synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14] synonym: "hippurase activity" EXACT [EC:3.5.1.14] synonym: "histozyme activity" RELATED [EC:3.5.1.14] synonym: "L-amino-acid acylase activity" EXACT [EC:3.5.1.14] synonym: "L-aminoacylase activity" EXACT [EC:3.5.1.14] synonym: "long acyl amidoacylase activity" EXACT [EC:3.5.1.14] synonym: "N-acyl-L-amino-acid amidohydrolase activity" EXACT [EC:3.5.1.14] synonym: "short acyl amidoacylase activity" EXACT [EC:3.5.1.14] xref: EC:3.5.1.14 xref: MetaCyc:AMINOACYLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004047 name: aminomethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] subset: gosubset_prok synonym: "glycine synthase activity" RELATED [EC:2.1.2.10] synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10] synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "T-protein" RELATED [EC:2.1.2.10] synonym: "tetrahydrofolate aminomethyltransferase activity" EXACT [EC:2.1.2.10] xref: EC:2.1.2.10 xref: MetaCyc:GCVT-RXN is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0004048 name: anthranilate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate." [EC:2.4.2.18, RHEA:11771] subset: gosubset_prok synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate diphosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate transferase activity" EXACT [EC:2.4.2.18] synonym: "PRT" RELATED [EC:2.4.2.18] xref: EC:2.4.2.18 xref: KEGG:R01073 xref: MetaCyc:PRTRANS-RXN xref: RHEA:11771 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004049 name: anthranilate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27] subset: gosubset_prok synonym: "anthranilate synthetase activity" EXACT [EC:4.1.3.27] synonym: "chorismate pyruvate-lyase (amino-accepting) activity" EXACT [EC:4.1.3.27] xref: EC:4.1.3.27 xref: MetaCyc:ANTHRANSYN-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004050 name: apyrase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN] comment: This term was made obsolete because it represents a gene product which can catalyze two reactions. is_obsolete: true consider: GO:0017110 consider: GO:0017111 [Term] id: GO:0004051 name: arachidonate 5-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34] subset: gosubset_prok synonym: "5-delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5Delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonate:oxygen 5-oxidoreductase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic acid 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34] synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34] synonym: "leukotriene-A4 synthase activity" EXACT [EC:1.13.11.34] synonym: "LTA synthase activity" NARROW [EC:1.13.11.34] xref: EC:1.13.11.34 xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN xref: Reactome:7163 "arachidonate 5-lipoxygenase activity" is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004052 name: arachidonate 12-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31, RHEA:10431] synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31] synonym: "12Delta-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "12S-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "arachidonate:oxygen 12-oxidoreductase activity" EXACT [EC:1.13.11.31] synonym: "C-12 lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "delta12-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31] synonym: "LTA4 synthase activity" EXACT [EC:1.13.11.31] xref: EC:1.13.11.31 xref: KEGG:R01596 xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN xref: RHEA:10431 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004053 name: arginase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1] subset: gosubset_prok synonym: "arginine amidinase activity" EXACT [EC:3.5.3.1] synonym: "arginine transamidinase activity" EXACT [EC:3.5.3.1] synonym: "canavanase activity" EXACT [EC:3.5.3.1] synonym: "L-arginase activity" EXACT [EC:3.5.3.1] synonym: "L-arginine amidinohydrolase activity" EXACT [EC:3.5.3.1] xref: EC:3.5.3.1 xref: MetaCyc:ARGINASE-RXN xref: Reactome:7167 "arginase activity" is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004054 name: arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+)." [EC:2.7.3.3, RHEA:22943] synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" EXACT [EC:2.7.3.3] synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3] synonym: "arginine phosphokinase activity" EXACT [EC:2.7.3.3] synonym: "ATP:L-arginine N-phosphotransferase activity" EXACT [EC:2.7.3.3] xref: EC:2.7.3.3 xref: KEGG:R00554 xref: MetaCyc:ARGININE-KINASE-RXN xref: RHEA:22943 is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004055 name: argininosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5] subset: gosubset_prok synonym: "arginine succinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinic acid synthetase activity" EXACT [EC:6.3.4.5] synonym: "arginosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "citrulline--aspartate ligase activity" EXACT [EC:6.3.4.5] synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [EC:6.3.4.5] xref: EC:6.3.4.5 xref: MetaCyc:ARGSUCCINSYN-RXN xref: Reactome:7171 "argininosuccinate synthase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004056 name: argininosuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1] subset: gosubset_prok synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "arginine-succinate lyase activity" EXACT [EC:4.3.2.1] synonym: "argininosuccinic acid lyase activity" EXACT [EC:4.3.2.1] synonym: "arginosuccinase activity" EXACT [EC:4.3.2.1] synonym: "N-(L-argininosuccinate) arginine-lyase activity" EXACT [EC:4.3.2.1] synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" EXACT [EC:4.3.2.1] xref: EC:4.3.2.1 xref: MetaCyc:ARGSUCCINLYA-RXN xref: Reactome:7173 "argininosuccinate lyase activity" is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004057 name: arginyltransferase activity namespace: molecular_function alt_id: GO:0042172 def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8] subset: gosubset_prok synonym: "arginine transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA-protein transferase activity" EXACT [] synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8] xref: EC:2.3.2.8 xref: MetaCyc:ARGINYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0004058 name: aromatic-L-amino-acid decarboxylase activity namespace: molecular_function alt_id: GO:0016400 def: "Catalysis of the reaction: L-tryptophan = tryptamine + CO2." [EC:4.1.1.28] synonym: "5-hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic amino acid decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase activity" EXACT [EC:4.1.1.28] synonym: "DOPA decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "L-DOPA decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "tryptophan decarboxylase activity" EXACT [EC:4.1.1.28] xref: EC:4.1.1.28 xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN xref: Reactome:7178 "aromatic-L-amino-acid decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004059 name: aralkylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87] synonym: "AANAT activity" EXACT [EC:2.3.1.87] synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "arylalkylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87] synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87] synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87] synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87] xref: EC:2.3.1.87 xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:7181 "aralkylamine N-acetyltransferase activity" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004060 name: arylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5] subset: gosubset_prok synonym: "2-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "4-aminobiphenyl N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl CoA-arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetylase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "beta-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "indoleamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "p-aminosalicylate N-acetyltransferase activity" EXACT [EC:2.3.1.5] xref: EC:2.3.1.5 xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:7187 "arylamine N-acetyltransferase activity" xref: UM-BBD_enzymeID:e0341 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004061 name: arylformamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9] subset: gosubset_prok synonym: "aryl-formylamine amidohydrolase activity" EXACT [EC:3.5.1.9] synonym: "formamidase I" RELATED [EC:3.5.1.9] synonym: "formamidase II" RELATED [EC:3.5.1.9] synonym: "formylase activity" EXACT [EC:3.5.1.9] synonym: "formylkynureninase activity" EXACT [EC:3.5.1.9] synonym: "formylkynurenine formamidase activity" EXACT [EC:3.5.1.9] synonym: "kynurenine formamidase activity" EXACT [EC:3.5.1.9] xref: EC:3.5.1.9 xref: MetaCyc:ARYLFORMAMIDASE-RXN xref: Reactome:7190 "arylformamidase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004062 name: aryl sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] subset: gosubset_prok synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "aryl sulphotransferase activity" EXACT [] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "PST" RELATED [EC:2.8.2.1] synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] xref: EC:2.8.2.1 xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN xref: Reactome:7193 "aryl sulfotransferase activity" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004063 name: aryldialkylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1] subset: gosubset_prok synonym: "A-esterase activity" BROAD [EC:3.1.8.1] synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1] synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1] synonym: "esterase B1" RELATED [EC:3.1.8.1] synonym: "esterase E4" RELATED [EC:3.1.8.1] synonym: "OPH" RELATED [EC:3.1.8.1] synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1] synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1] synonym: "paraoxonase activity" BROAD [EC:3.1.8.1] synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1] synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1] xref: EC:3.1.8.1 xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN xref: UM-BBD_enzymeID:e0054 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004064 name: arylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] subset: gosubset_prok synonym: "A-esterase activity" BROAD [EC:3.1.1.2] synonym: "aromatic esterase" NARROW [EC:3.1.1.2] synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2] synonym: "paraoxonase activity" BROAD [EC:3.1.1.2] xref: EC:3.1.1.2 xref: MetaCyc:ARYLESTERASE-RXN xref: UM-BBD_reactionID:r0757 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004065 name: arylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1] subset: gosubset_prok synonym: "4-methylumbelliferyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulphate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulphatase activity" EXACT [] synonym: "estrogen sulfatase activity" EXACT [EC:3.1.6.1] synonym: "nitrocatechol sulfatase activity" EXACT [EC:3.1.6.1] synonym: "p-nitrophenyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenolsulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1] synonym: "sulfatase activity" RELATED [EC:3.1.6.1] xref: EC:3.1.6.1 xref: MetaCyc:ARYLSULFAT-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004066 name: asparagine synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4] subset: gosubset_prok synonym: "AS" RELATED [EC:6.3.5.4] synonym: "AS-B activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase B activity" EXACT [EC:6.3.5.4] synonym: "glutamine-dependent asparagine synthetase activity" EXACT [EC:6.3.5.4] synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.4] xref: EC:6.3.5.4 xref: MetaCyc:ASNSYNB-RXN xref: Reactome:7213 "asparagine synthase (glutamine-hydrolyzing) activity" is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004067 name: asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] subset: gosubset_prok synonym: "alpha-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "asparaginase II" RELATED [EC:3.5.1.1] synonym: "colaspase activity" EXACT [EC:3.5.1.1] synonym: "crasnitin" RELATED [EC:3.5.1.1] synonym: "elspar" RELATED [EC:3.5.1.1] synonym: "L-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.1] synonym: "leunase activity" EXACT [EC:3.5.1.1] xref: EC:3.5.1.1 xref: MetaCyc:ASPARAGHYD-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004068 name: aspartate 1-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] subset: gosubset_prok synonym: "aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" EXACT [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase activity" EXACT [EC:4.1.1.11] synonym: "L-aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] xref: EC:4.1.1.11 xref: MetaCyc:ASPDECARBOX-RXN xref: MetaCyc:PWY-5155 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004069 name: L-aspartate:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] subset: gosubset_prok synonym: "2-oxoglutarate-glutamate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "AAT" RELATED [EC:2.6.1.1] synonym: "aspartate alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate aminotransferase activity" BROAD [] synonym: "aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "aspartate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "aspartic acid aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartyl aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "AspT" RELATED [EC:2.6.1.1] synonym: "glutamate oxaloacetate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic oxalic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--aspartic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--oxaloacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-aspartic aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-oxalacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1] synonym: "L-aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate-transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "oxaloacetate transferase activity" EXACT [EC:2.6.1.1] synonym: "oxaloacetate-aspartate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "transaminase A activity" RELATED [EC:2.6.1.1] xref: EC:2.6.1.1 xref: MetaCyc:ASPAMINOTRANS-RXN xref: Reactome:7220 "L-aspartate:2-oxoglutarate aminotransferase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004070 name: aspartate carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20016] subset: gosubset_prok synonym: "aspartate carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic acid transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartic transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "ATCase activity" EXACT [EC:2.1.3.2] synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" EXACT [EC:2.1.3.2] synonym: "carbamoylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "carbamylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] xref: EC:2.1.3.2 xref: KEGG:R01397 xref: MetaCyc:ASPCARBTRANS-RXN xref: Reactome:7225 "aspartate carbamoyltransferase activity" xref: RHEA:20016 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0004071 name: aspartate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1] subset: gosubset_prok synonym: "asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-aspartate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.1] xref: EC:6.3.1.1 xref: MetaCyc:ASNSYNA-RXN is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0004072 name: aspartate kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [EC:2.7.2.4, RHEA:23779] subset: gosubset_prok synonym: "aspartic kinase activity" EXACT [EC:2.7.2.4] synonym: "aspartokinase activity" EXACT [EC:2.7.2.4] synonym: "ATP:L-aspartate 4-phosphotransferase activity" EXACT [EC:2.7.2.4] synonym: "beta-aspartokinase activity" EXACT [EC:2.7.2.4] xref: EC:2.7.2.4 xref: KEGG:R00480 xref: MetaCyc:ASPARTATEKIN-RXN xref: RHEA:23779 is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004073 name: aspartate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH." [EC:1.2.1.11, RHEA:24287] subset: gosubset_prok synonym: "ASA dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" EXACT [EC:1.2.1.11] xref: EC:1.2.1.11 xref: KEGG:R02291 xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:24287 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004074 name: biliverdin reductase activity namespace: molecular_function def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24] synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24] xref: EC:1.3.1.24 xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN xref: Reactome:7240 "biliverdin reductase activity" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004075 name: biotin carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] subset: gosubset_prok synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXACT [EC:6.3.4.14] synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14] xref: EC:6.3.4.14 xref: MetaCyc:BIOTIN-CARBOXYL-RXN is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004076 name: biotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+)." [EC:2.8.1.6, RHEA:22063] subset: gosubset_prok synonym: "biotin synthetase activity" EXACT [EC:2.8.1.6] synonym: "dethiobiotin:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.6] xref: EC:2.8.1.6 xref: KEGG:R01078 xref: MetaCyc:2.8.1.6-RXN xref: RHEA:22063 is_a: GO:0016783 ! sulfurtransferase activity is_a: GO:0070283 ! radical SAM enzyme activity [Term] id: GO:0004077 name: biotin-[acetyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15] subset: gosubset_prok synonym: "acetyl CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15] synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15] synonym: "biotin-acetyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.15] synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "HCS" RELATED [EC:6.3.4.15] xref: EC:6.3.4.15 xref: MetaCyc:BIOTINLIG-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004078 name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11] synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11] synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11] synonym: "holocarboxylase-synthetase activity" EXACT [EC:6.3.4.11] xref: EC:6.3.4.11 xref: MetaCyc:6.3.4.11-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004079 name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [] synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-transcarboxylase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9] xref: EC:6.3.4.9 xref: MetaCyc:6.3.4.9-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004080 name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10] synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.10] synonym: "holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] xref: EC:6.3.4.10 xref: MetaCyc:6.3.4.10-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004081 name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726] subset: gosubset_prok synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17] synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW [] synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] xref: EC:3.6.1.17 xref: MetaCyc:3.6.1.17-RXN is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: GO:0004082 name: bisphosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" EXACT [EC:5.4.2.4] synonym: "biphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4] synonym: "BPGM activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceric mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "DPGM" RELATED [EC:5.4.2.4] synonym: "glycerate phosphomutase activity" EXACT [EC:5.4.2.4] xref: EC:5.4.2.4 xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004083 name: 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate." [EC:3.1.3.13, RHEA:21907] synonym: "bisphosphoglycerate 2-phosphatase activity" BROAD [EC:3.1.3.13] xref: EC:3.1.3.13 xref: KEGG:R01516 xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:21907 is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity [Term] id: GO:0004084 name: branched-chain-amino-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid." [EC:2.6.1.42, GOC:mah] subset: gosubset_prok synonym: "branched-chain amino acid aminotransferase activity" EXACT [] synonym: "branched-chain amino acid-glutamate transaminase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "glutamate-branched-chain amino acid transaminase activity" EXACT [EC:2.6.1.42] synonym: "L-branched chain amino acid aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "transaminase B activity" RELATED [EC:2.6.1.42] xref: EC:2.6.1.42 xref: Reactome:70697 "branched-chain-amino-acid transaminase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004085 name: butyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + ETF = 2-butenoyl-CoA + reduced ETF." [EC:1.3.99.2] subset: gosubset_prok synonym: "3-hydroxyacyl CoA reductase activity" EXACT [EC:1.3.99.2] synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2] synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2] synonym: "butyryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "butyryl dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "enoyl-coenzyme A reductase activity" EXACT [EC:1.3.99.2] synonym: "ethylene reductase activity" EXACT [EC:1.3.99.2] synonym: "short-chain acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "short-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.2] synonym: "unsaturated acyl coenzyme A reductase activity" EXACT [EC:1.3.99.2] synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.99.2] xref: EC:1.3.99.2 xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0013 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004086 name: carbamoyl-phosphate synthase activity namespace: molecular_function def: "Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah] subset: gosubset_prok synonym: "carbamoyl phosphate synthase activity" EXACT [] xref: EC:6.3.-.- is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004087 name: carbamoyl-phosphate synthase (ammonia) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate." [EC:6.3.4.16, RHEA:10627] subset: gosubset_prok synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT [] synonym: "carbamoyl-phosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamoyl-phosphate synthetase I activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase (ammonia)" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16] synonym: "carbmoylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide--ammonia ligase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" EXACT [EC:6.3.4.16] synonym: "CPS I activity" NARROW [EC:6.3.4.16] xref: EC:6.3.4.16 xref: KEGG:R00149 xref: MetaCyc:6.3.4.16-RXN xref: Reactome:7296 "carbamoyl-phosphate synthase (ammonia) activity" xref: RHEA:10627 is_a: GO:0004086 ! carbamoyl-phosphate synthase activity [Term] id: GO:0004088 name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5] subset: gosubset_prok synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "carbamoyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoylphosphate synthetase II activity" EXACT [EC:6.3.5.5] synonym: "carbamyl phosphate synthetase (glutamine) activity" EXACT [EC:6.3.5.5] synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] synonym: "CPS activity" EXACT [EC:6.3.5.5] synonym: "GD-CPSase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] xref: EC:6.3.5.5 xref: MetaCyc:CARBPSYN-RXN xref: Reactome:7299 "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity" is_a: GO:0004086 ! carbamoyl-phosphate synthase activity is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004089 name: carbonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] subset: gosubset_prok synonym: "anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase activity" EXACT [EC:4.2.1.1] synonym: "carbonic acid anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1] synonym: "carbonic anhydrase activity" EXACT [] synonym: "carbonic dehydratase activity" EXACT [EC:4.2.1.1] synonym: "carboxyanhydrase activity" EXACT [EC:4.2.1.1] xref: EC:4.2.1.1 xref: MetaCyc:CARBODEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004090 name: carbonyl reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184] subset: gosubset_prok synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184] synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184] synonym: "ALR3" RELATED [EC:1.1.1.184] synonym: "carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH2-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "nonspecific NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184] synonym: "secondary-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.184] synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184] xref: EC:1.1.1.184 xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004091 name: carboxylesterase activity namespace: molecular_function alt_id: GO:0004302 alt_id: GO:0004759 alt_id: GO:0016789 def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1] subset: gosubset_prok synonym: "Ali-esterase activity" RELATED [EC:3.1.1.1] synonym: "ali-esterase activity" EXACT [EC:3.1.1.1] synonym: "alpha-carboxylesterase activity" EXACT [EC:3.1.1.1] synonym: "B-esterase activity" RELATED [EC:3.1.1.1] synonym: "carboxyesterase activity" EXACT [EC:3.1.1.1] synonym: "carboxyl ester hydrolase activity" EXACT [EC:3.1.1.1] synonym: "carboxylate esterase activity" EXACT [EC:3.1.1.1] synonym: "carboxylic acid esterase activity" EXACT [] synonym: "carboxylic ester hydrolase activity" EXACT [] synonym: "carboxylic esterase activity" EXACT [EC:3.1.1.1] synonym: "cocaine esterase activity" NARROW [EC:3.1.1.1] synonym: "esterase A" RELATED [EC:3.1.1.1] synonym: "esterase B" RELATED [EC:3.1.1.1] synonym: "nonspecific carboxylesterase activity" EXACT [EC:3.1.1.1] synonym: "procaine esterase activity" NARROW [EC:3.1.1.1] synonym: "serine esterase activity" EXACT [] synonym: "triacetin esterase" NARROW [EC:3.1.1.1] synonym: "vitamin A esterase" NARROW [EC:3.1.1.1] xref: EC:3.1.1.1 xref: KEGG:R00630 xref: MetaCyc:CARBOXYLESTERASE-RXN xref: UM-BBD_reactionID:r1025 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004092 name: carnitine O-acetyltransferase activity namespace: molecular_function alt_id: GO:0004093 alt_id: GO:0004094 def: "Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [EC:2.3.1.7, RHEA:21139] subset: gosubset_prok synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetylcarnitine transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyl coenzyme A transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetylase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine O-acetyltransferase I activity" NARROW [] synonym: "carnitine O-acetyltransferase II activity" NARROW [] synonym: "carnitine-acetyl-CoA transferase activity" EXACT [EC:2.3.1.7] synonym: "CATC" RELATED [EC:2.3.1.7] xref: EC:2.3.1.7 xref: KEGG:R02396 xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN xref: Reactome:7311 "carnitine O-acetyltransferase activity" xref: RHEA:21139 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004095 name: carnitine O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21] synonym: "acylcarnitine transferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21] synonym: "CPT" RELATED [EC:2.3.1.21] synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21] synonym: "CPT-A" RELATED [EC:2.3.1.21] synonym: "CPT-B" RELATED [EC:2.3.1.21] synonym: "CPTi" RELATED [EC:2.3.1.21] synonym: "CPTo" RELATED [EC:2.3.1.21] synonym: "L-carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoylcarnitine transferase activity" EXACT [EC:2.3.1.21] xref: EC:2.3.1.21 xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN xref: Reactome:7324 "carnitine O-palmitoyltransferase activity" is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016416 ! O-palmitoyltransferase activity [Term] id: GO:0004096 name: catalase activity namespace: molecular_function alt_id: GO:0016952 alt_id: GO:0016953 def: "Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6] subset: gosubset_prok synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "caperase activity" EXACT [EC:1.11.1.6] synonym: "CAT" RELATED [EC:1.11.1.6] synonym: "catalase reaction" EXACT [] synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6] synonym: "equilase activity" EXACT [EC:1.11.1.6] synonym: "haem catalase activity" NARROW [] synonym: "heme catalase activity" NARROW [] synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6] synonym: "manganese catalase activity" NARROW [] synonym: "optidase activity" EXACT [EC:1.11.1.6] xref: EC:1.11.1.6 xref: MetaCyc:CATAL-RXN xref: Reactome:76029 "catalase activity" xref: UM-BBD_enzymeID:e0834 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004097 name: catechol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1] subset: gosubset_prok synonym: "1,2-benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.1] synonym: "catecholase" BROAD [EC:1.10.3.1] synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "dopa oxidase" BROAD [EC:1.10.3.1] synonym: "o-diphenol oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1] synonym: "phenolase activity" BROAD [EC:1.10.3.1] synonym: "polyphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "pyrocatechol oxidase" BROAD [EC:1.10.3.1] synonym: "tyrosinase activity" BROAD [EC:1.10.3.1] xref: EC:1.10.3.1 xref: MetaCyc:CATECHOL-OXIDASE-RXN is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0004098 name: cerebroside-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate." [EC:3.1.6.8] subset: gosubset_prok synonym: "arylsulfatase A activity" EXACT [EC:3.1.6.8] synonym: "cerebroside sulfate sulfatase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-sulphatase activity" EXACT [] xref: EC:3.1.6.8 xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004099 name: chitin deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41] subset: gosubset_prok synonym: "chitin amidohydrolase activity" EXACT [EC:3.5.1.41] xref: EC:3.5.1.41 xref: MetaCyc:CHITIN-DEACETYLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0004100 name: chitin synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n+1)." [EC:2.4.1.16] subset: gosubset_prok synonym: "chitin synthetase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16] xref: EC:2.4.1.16 xref: MetaCyc:CHITIN-SYNTHASE-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004102 name: choline O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18824] subset: gosubset_prok synonym: "acetyl-CoA:choline O-acetyltransferase activity" EXACT [EC:2.3.1.6] synonym: "CHOACTase activity" EXACT [EC:2.3.1.6] synonym: "choline acetylase activity" EXACT [EC:2.3.1.6] synonym: "choline acetyltransferase activity" EXACT [EC:2.3.1.6] xref: EC:2.3.1.6 xref: KEGG:R01023 xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN xref: Reactome:264627 "choline O-acetyltransferase activity" xref: RHEA:18824 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004103 name: choline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12840] subset: gosubset_prok synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32] synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32] synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32] synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32] xref: EC:2.7.1.32 xref: KEGG:R01021 xref: MetaCyc:CHOLINE-KINASE-RXN xref: RHEA:12840 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004104 name: cholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] subset: gosubset_prok synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8] synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8] synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "BtChoEase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8] synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8] synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8] xref: EC:3.1.1.8 xref: MetaCyc:CHOLINESTERASE-RXN xref: Reactome:8144 "cholinesterase activity" is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004105 name: choline-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15] subset: gosubset_prok synonym: "CDP-choline pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "CDP-choline synthetase activity" EXACT [EC:2.7.7.15] synonym: "choline phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP-phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "cytidine diphosphocholine pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine transferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine:CTP cytidylyltransferase activity" EXACT [EC:2.7.7.15] xref: EC:2.7.7.15 xref: MetaCyc:2.7.7.15-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004106 name: chorismate mutase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5, RHEA:13900] subset: gosubset_prok synonym: "chorismate pyruvatemutase activity" EXACT [EC:5.4.99.5] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5] xref: EC:5.4.99.5 xref: KEGG:R01715 xref: MetaCyc:CHORISMATEMUT-RXN xref: RHEA:13900 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0004107 name: chorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5, RHEA:21023] subset: gosubset_prok synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" EXACT [EC:4.2.3.5] xref: EC:4.2.3.5 xref: KEGG:R01714 xref: MetaCyc:CHORISMATE-SYNTHASE-RXN xref: Reactome:8153 "chorismate synthase activity" xref: RHEA:21023 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0004108 name: citrate (Si)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073] comment: Note that this function was formerly EC:4.1.3.7. subset: gosubset_prok synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1] synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1] synonym: "citrate synthase activity" BROAD [EC:2.3.3.1] synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1] synonym: "citric synthase activity" EXACT [EC:2.3.3.1] synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrogenase activity" EXACT [EC:2.3.3.1] synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1] synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1] synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1] xref: EC:2.3.3.1 xref: MetaCyc:CITSYN-RXN xref: Reactome:8157 "citrate (Si)-synthase activity" is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004109 name: coproporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18260] subset: gosubset_prok synonym: "coprogen oxidase activity" EXACT [] synonym: "coproporphyrinogen-III oxidase activity" EXACT [] synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" EXACT [EC:1.3.3.3] synonym: "coproporphyrinogenase activity" EXACT [] xref: EC:1.3.3.3 xref: KEGG:R03220 xref: MetaCyc:RXN0-1461 xref: Reactome:8160 "coproporphyrinogen oxidase activity" xref: RHEA:18260 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004110 name: corticosteroid side-chain-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21, RHEA:17864] synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" EXACT [EC:5.3.1.21] synonym: "11-deoxycorticosterone ketol-isomerase activity" EXACT [EC:5.3.1.21] xref: EC:5.3.1.21 xref: KEGG:R04165 xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN xref: RHEA:17864 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004111 name: creatine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [EC:2.7.3.2, RHEA:17160] synonym: "adenosine triphosphate-creatine transphosphorylase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine N-phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "BB-CK" RELATED [EC:2.7.3.2] synonym: "CK" RELATED [EC:2.7.3.2] synonym: "CK-BB" RELATED [EC:2.7.3.2] synonym: "CK-MB" RELATED [EC:2.7.3.2] synonym: "CK-MM" RELATED [EC:2.7.3.2] synonym: "CKMiMi" RELATED [EC:2.7.3.2] synonym: "creatine phosphokinase activity" EXACT [EC:2.7.3.2] synonym: "creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "MB-CK" RELATED [EC:2.7.3.2] synonym: "Mi-CK" RELATED [EC:2.7.3.2] synonym: "MiMi-CK" RELATED [EC:2.7.3.2] synonym: "MM-CK" RELATED [EC:2.7.3.2] synonym: "phosphocreatine kinase activity" EXACT [EC:2.7.3.2] xref: EC:2.7.3.2 xref: KEGG:R01881 xref: MetaCyc:CREATINE-KINASE-RXN xref: Reactome:8202 "creatine kinase activity" xref: RHEA:17160 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0004112 name: cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah] subset: gosubset_prok xref: EC:3.1.4.- is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004113 name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37] subset: gosubset_prok synonym: "2',3'-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [] synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37] synonym: "2':3'-CNMP-3'-ase activity" EXACT [EC:3.1.4.37] synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "CNPase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37] synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37] xref: EC:3.1.4.37 xref: MetaCyc:3.1.4.37-RXN is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004114 name: 3',5'-cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] subset: gosubset_prok synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-cyclonucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17] synonym: "cyclic nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.17] synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "PDE" RELATED [EC:3.1.4.17] xref: EC:3.1.4.17 xref: MetaCyc:3.1.4.17-RXN xref: Reactome:8210 "3',5'-cyclic-nucleotide phosphodiesterase activity" is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004115 name: 3',5'-cyclic-AMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai] subset: gosubset_prok synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT [] synonym: "cAMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT [] xref: EC:3.1.4.- xref: MetaCyc:RXN0-5038 xref: Reactome:8212 "3',5'-cyclic-AMP phosphodiesterase activity" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004117 name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah] xref: EC:3.1.4.- xref: Reactome:8219 "calmodulin-dependent cyclic-nucleotide phosphodiesterase activity" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004118 name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4.- is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004119 name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4.- is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004120 name: photoreceptor cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] xref: EC:3.1.4.- is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004121 name: cystathionine beta-lyase activity namespace: molecular_function alt_id: GO:0008799 def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8] subset: gosubset_prok synonym: "beta C-S lyase activity" EXACT [EC:4.4.1.8] synonym: "beta-cystathionase activity" EXACT [EC:4.4.1.8] synonym: "cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "cystine lyase activity" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.8] xref: EC:4.4.1.8 xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004122 name: cystathionine beta-synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] subset: gosubset_prok synonym: "beta-thionase activity" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine)" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [EC:4.2.1.22] synonym: "methylcysteine synthase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22] xref: EC:4.2.1.22 xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004123 name: cystathionine gamma-lyase activity namespace: molecular_function alt_id: GO:0016225 def: "Catalysis of the reaction: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate." [EC:4.4.1.1] subset: gosubset_prok synonym: "cystalysin" RELATED [EC:4.4.1.1] synonym: "cystathionase activity" EXACT [EC:4.4.1.1] synonym: "cystathioninase activity" EXACT [EC:4.4.1.1] synonym: "cysteine desulfhydrase activity" EXACT [] synonym: "cystine desulfhydrase activity" EXACT [EC:4.4.1.1] synonym: "gamma-CTL" RELATED [EC:4.4.1.1] synonym: "gamma-cystathionase activity" EXACT [EC:4.4.1.1] synonym: "homoserine deaminase activity" EXACT [EC:4.4.1.1] synonym: "homoserine deaminase-cystathionase activity" EXACT [EC:4.4.1.1] synonym: "homoserine dehydratase activity" EXACT [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating)" EXACT [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.1] xref: EC:4.4.1.1 xref: MetaCyc:CYSTAGLY-RXN xref: Reactome:8260 "cystathionine gamma-lyase activity" is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004124 name: cysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [EC:4.2.99.8] comment: Note that this function was formerly 4.2.99.8. subset: gosubset_prok synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47] xref: EC:2.5.1.47 xref: MetaCyc:ACSERLY-RXN xref: Reactome:8263 "cysteine synthase activity" is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0004125 name: L-seryl-tRNASec selenium transferase activity namespace: molecular_function def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1] subset: gosubset_prok synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "cysteinyl-tRNASec-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNASel-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASec synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASel synthase activity" EXACT [EC:2.9.1.1] synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "selenocysteine synthase activity" EXACT [] synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT [] synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1] xref: EC:2.9.1.1 xref: MetaCyc:2.9.1.1-RXN is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups [Term] id: GO:0004126 name: cytidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5] subset: gosubset_prok synonym: "cytidine aminohydrolase activity" EXACT [EC:3.5.4.5] synonym: "cytosine nucleoside deaminase activity" EXACT [EC:3.5.4.5] xref: EC:3.5.4.5 xref: MetaCyc:CYTIDEAM2-RXN xref: Reactome:8270 "cytidine deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004127 name: cytidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14] subset: gosubset_prok synonym: "ATP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "ATP:UMP-CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "CMP kinase activity" NARROW [EC:2.7.4.14] synonym: "CTP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "cytidine monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14] synonym: "deoxycytidine monophosphokinase activity" EXACT [EC:2.7.4.14] synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14] synonym: "pyrimidine nucleoside monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "UMP-CMP kinase activity" EXACT [EC:2.7.4.14] xref: EC:2.7.4.14 xref: MetaCyc:CMPKI-RXN is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004128 name: cytochrome-b5 reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684] synonym: "cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH 5alpha-reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome-b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-ferricytochrome b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] xref: EC:1.6.2.2 xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN xref: Reactome:8276 "cytochrome-b5 reductase activity" is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: GO:0004129 name: cytochrome-c oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. subset: gosubset_prok synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1] synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1] synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1] synonym: "indophenol oxidase" NARROW [EC:1.9.3.1] synonym: "indophenolase" NARROW [EC:1.9.3.1] synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1] synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1] xref: EC:1.9.3.1 xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN xref: Reactome:8283 "cytochrome-c oxidase activity" is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0016676 ! oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor [Term] id: GO:0004130 name: cytochrome-c peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5] subset: gosubset_prok synonym: "apocytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-551 peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-H2O oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome peroxidase activity" EXACT [EC:1.11.1.5] synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5] xref: EC:1.11.1.5 xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004131 name: cytosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1] subset: gosubset_prok synonym: "cytosine aminohydrolase activity" EXACT [EC:3.5.4.1] synonym: "isocytosine deaminase activity" EXACT [EC:3.5.4.1] xref: EC:3.5.4.1 xref: MetaCyc:CYTDEAM-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004132 name: dCMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12] subset: gosubset_prok synonym: "dCMP aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxy-CMP-deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine monophosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-phosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate deaminase activity" EXACT [EC:3.5.4.12] xref: EC:3.5.4.12 xref: MetaCyc:DCMP-DEAMINASE-RXN xref: Reactome:8340 "dCMP deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004133 name: glycogen debranching enzyme activity namespace: molecular_function def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0004134 name: 4-alpha-glucanotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan." [EC:2.4.1.25] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "amylomaltase activity" EXACT [EC:2.4.1.25] synonym: "D-enzyme activity" RELATED [EC:2.4.1.25] synonym: "debranching enzyme maltodextrin glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25] synonym: "dextrin transglycosylase activity" EXACT [EC:2.4.1.25] synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25] synonym: "oligo-1,4-1,4-glucantransferase activity" EXACT [EC:2.4.1.25] xref: EC:2.4.1.25 xref: MetaCyc:AMYLOMALT-RXN xref: MetaCyc:RXN-1828 xref: MetaCyc:RXN-9023 xref: Reactome:8344 "4-alpha-glucanotransferase activity" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004135 name: amylo-alpha-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the 1,6 glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amylo-1,6-glucosidase activity" EXACT [] synonym: "amylopectin 1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33] synonym: "dextrin-1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.33] xref: EC:3.2.1.33 xref: MetaCyc:3.2.1.33-RXN xref: Reactome:8347 "amylo-alpha-1,6-glucosidase activity" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0004558 ! alpha-glucosidase activity [Term] id: GO:0004136 name: deoxyadenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+)." [EC:2.7.1.76, RHEA:23455] subset: gosubset_prok synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.76] synonym: "deoxyadenosine kinase (phosphorylating)" EXACT [EC:2.7.1.76] synonym: "purine-deoxyribonucleoside kinase activity" EXACT [EC:2.7.1.76] xref: EC:2.7.1.76 xref: KEGG:R02089 xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN xref: RHEA:23455 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004137 name: deoxycytidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74] subset: gosubset_prok synonym: "2'-deoxycytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "Ara-C kinase activity" EXACT [EC:2.7.1.74] synonym: "arabinofuranosylcytosine kinase activity" EXACT [EC:2.7.1.74] synonym: "deoxycytidine kinase (phosphorylating)" EXACT [EC:2.7.1.74] synonym: "deoxycytidine-cytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.74] xref: EC:2.7.1.74 xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004138 name: deoxyguanosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+)." [EC:2.7.1.113, RHEA:19204] subset: gosubset_prok synonym: "(dihydroxypropoxymethyl)guanine kinase activity" EXACT [EC:2.7.1.113] synonym: "2'-deoxyguanosine kinase activity" EXACT [EC:2.7.1.113] synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] synonym: "deoxyguanosine kinase (phosphorylating)" EXACT [EC:2.7.1.113] synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] xref: EC:2.7.1.113 xref: KEGG:R01967 xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN xref: RHEA:19204 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004139 name: deoxyribose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12824] subset: gosubset_prok synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" EXACT [EC:4.1.2.4] synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" EXACT [EC:4.1.2.4] synonym: "2-deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4] synonym: "deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "phosphodeoxyriboaldolase activity" EXACT [EC:4.1.2.4] xref: EC:4.1.2.4 xref: KEGG:R01066 xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN xref: RHEA:12824 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004140 name: dephospho-CoA kinase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+)." [EC:2.7.1.24, RHEA:18248] subset: gosubset_prok synonym: "3'-dephospho-CoA kinase activity" EXACT [EC:2.7.1.24] synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase (phosphorylating)" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24] xref: EC:2.7.1.24 xref: KEGG:R00130 xref: MetaCyc:DEPHOSPHOCOAKIN-RXN xref: Reactome:8372 "dephospho-CoA kinase activity" xref: RHEA:18248 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004141 name: dethiobiotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate." [EC:6.3.3.3, RHEA:15808] subset: gosubset_prok synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.3] synonym: "desthiobiotin synthase activity" EXACT [EC:6.3.3.3] synonym: "DTB synthetase activity" EXACT [EC:6.3.3.3] xref: EC:6.3.3.3 xref: KEGG:R03182 xref: MetaCyc:DETHIOBIOTIN-SYN-RXN xref: RHEA:15808 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0004142 name: diacylglycerol cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline diglyceride phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2] synonym: "CPT" RELATED [EC:2.7.8.2] synonym: "cytidine diphosphocholine glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "cytidine diphosphorylcholine diglyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "diacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphocholine diacylglyceroltransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphorylcholine--glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] xref: EC:2.7.8.2 xref: MetaCyc:RXN-5781 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0004143 name: diacylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh] subset: gosubset_prok synonym: "1,2-diacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.107] synonym: "1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "arachidonoyl-specific diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "ATP:diacylglycerol phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "CTP:diacylglycerol kinase activity" NARROW [] synonym: "DG kinase activity" EXACT [EC:2.7.1.107] synonym: "DGK activity" EXACT [EC:2.7.1.107] synonym: "diacylglycerol:ATP kinase activity" NARROW [EC:2.7.1.107] synonym: "diglyceride kinase activity" EXACT [EC:2.7.1.107] synonym: "sn-1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] xref: EC:2.7.1.107 xref: MetaCyc:DIACYLGLYKIN-RXN xref: Reactome:8381 "diacylglycerol kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004144 name: diacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] subset: gosubset_prok synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] xref: EC:2.3.1.20 xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: Reactome:8383 "diacylglycerol O-acyltransferase activity" is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0004145 name: diamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57] subset: gosubset_prok synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW [] synonym: "diamine acetyltransferase activity" EXACT [] synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW [] synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57] synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermidine/spermine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermine acetyltransferase" NARROW [] synonym: "spermine N(1)-acetyltransferase" NARROW [] synonym: "spermine N-acetyltransferase" RELATED [] xref: EC:2.3.1.57 xref: MetaCyc:DIAMACTRANS-RXN xref: Reactome:8388 "diamine N-acetyltransferase activity" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004146 name: dihydrofolate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3] subset: gosubset_prok synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.3] synonym: "7,8-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "DHFR" RELATED [EC:1.5.1.3] synonym: "dihydrofolate reductase:thymidylate synthase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolate reduction" EXACT [] synonym: "dihydrofolic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolic reductase activity" EXACT [EC:1.5.1.3] synonym: "folic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "folic reductase activity" EXACT [EC:1.5.1.3] synonym: "NADPH-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "pteridine reductase:dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "tetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.3] synonym: "thymidylate synthetase-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] xref: EC:1.5.1.3 xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004147 name: dihydrolipoamide branched chain acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain." [GOC:mah] subset: gosubset_prok synonym: "dihydrolipoamide branched chain transacylase activity" EXACT [] xref: EC:2.3.1.- is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity [Term] id: GO:0004148 name: dihydrolipoyl dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] subset: gosubset_prok synonym: "dehydrolipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "diaphorase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4] synonym: "dihydrolipoamide:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "dihydrolipoic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4] synonym: "dihydrothioctic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4] synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4] synonym: "L-protein activity" RELATED [EC:1.8.1.4] synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4] synonym: "LDP-Val activity" NARROW [EC:1.8.1.4] synonym: "lipoamide dehydrogenase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide oxidoreductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase activity" EXACT [EC:1.8.1.4] synonym: "lipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoic acid dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoyl dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] xref: EC:1.8.1.4 xref: MetaCyc:DIHYDLIPOXN-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0004149 name: dihydrolipoyllysine-residue succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61] subset: gosubset_prok synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT [] synonym: "dihydrolipoamide succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipolyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase (Escherichia coli) activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "lipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] xref: EC:2.3.1.61 is_a: GO:0016751 ! S-succinyltransferase activity [Term] id: GO:0004150 name: dihydroneopterin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25] subset: gosubset_prok synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" EXACT [EC:4.1.2.25] synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" EXACT [EC:4.1.2.25] xref: EC:4.1.2.25 xref: MetaCyc:H2NEOPTERINALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004151 name: dihydroorotase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.3, RHEA:24299] subset: gosubset_prok synonym: "(S)-dihydroorotate amidohydrolase activity" EXACT [EC:3.5.2.3] synonym: "carbamoylaspartic dehydrase activity" EXACT [EC:3.5.2.3] synonym: "DHOase activity" EXACT [EC:3.5.2.3] synonym: "dihydroorotate hydrolase activity" EXACT [EC:3.5.2.3] xref: EC:3.5.2.3 xref: KEGG:R01993 xref: MetaCyc:DIHYDROOROT-RXN xref: Reactome:8410 "dihydroorotase activity" xref: RHEA:24299 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004152 name: dihydroorotate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18076] subset: gosubset_prok synonym: "(DHO) dehydrogenase activity" RELATED [EC:1.3.5.2] synonym: "(S)-dihydroorotate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.3.5.2] synonym: "DHOdehase activity" EXACT [EC:1.3.5.2] synonym: "dihydoorotic acid dehydrogenase activity" EXACT [EC:1.3.5.2] synonym: "dihydroorotate:ubiquinone oxidoreductase activity" NARROW [EC:1.3.5.2] xref: EC:1.3.5.2 xref: KEGG:R01868 xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN xref: Reactome:8412 "dihydroorotate dehydrogenase activity" xref: RHEA:18076 is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0004153 name: dihydropterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3." [FB:FBrf0039640, GOC:jl, http://www.abbs.info/fulltxt/eng/35030306.htm, ISSN:05829879] is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004154 name: dihydropterin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide." [GOC:mah, PMID:1745247, PMID:6815189] xref: EC:1.5.3.- is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004155 name: 6,7-dihydropteridine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34] comment: Note that this function was formerly EC:1.6.99.7. subset: gosubset_prok synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "DHPR activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase (NADH) activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase activity" EXACT [] synonym: "dihydropteridine reduction" RELATED [] synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NADH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-specific dihydropteridine reductase activity" EXACT [EC:1.5.1.34] xref: EC:1.5.1.34 xref: MetaCyc:1.5.1.34-RXN xref: Reactome:8421 "6,7-dihydropteridine reductase activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004156 name: dihydropteroate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15] subset: gosubset_prok synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroic acid synthetase activity" EXACT [EC:2.5.1.15] synonym: "DHPS activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate diphosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate pyrophosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroic synthetase activity" EXACT [EC:2.5.1.15] xref: EC:2.5.1.15 xref: MetaCyc:H2PTEROATESYNTH-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004157 name: dihydropyrimidinase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2] subset: gosubset_prok synonym: "5,6-dihydropyrimidine amidohydrolase activity" EXACT [EC:3.5.2.2] synonym: "D-hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydantoin peptidase activity" EXACT [EC:3.5.2.2] synonym: "hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydropyrimidine hydrase activity" EXACT [EC:3.5.2.2] synonym: "pyrimidine hydrase activity" EXACT [EC:3.5.2.2] xref: EC:3.5.2.2 xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN xref: Reactome:8430 "dihydropyrimidinase activity" is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004158 name: dihydroorotate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444] subset: gosubset_prok synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] xref: EC:1.3.3.1 xref: KEGG:R01867 xref: MetaCyc:DIHYDROOROTOX-RXN xref: RHEA:15444 is_a: GO:0004152 ! dihydroorotate dehydrogenase activity is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004159 name: dihydrouracil dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+." [EC:1.3.1.1] synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.1] synonym: "dehydrogenase, dihydrouracil" EXACT [EC:1.3.1.1] synonym: "pyrimidine reductase activity" EXACT [EC:1.3.1.1] synonym: "thymine reductase activity" EXACT [EC:1.3.1.1] synonym: "uracil reductase activity" EXACT [EC:1.3.1.1] xref: EC:1.3.1.1 xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004160 name: dihydroxy-acid dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9] subset: gosubset_prok synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxy-acid hydro-lyase activity" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "acetohydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "DHAD" RELATED [EC:4.2.1.9] synonym: "dihydroxy acid dehydrase activity" EXACT [EC:4.2.1.9] xref: EC:4.2.1.9 xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004161 name: dimethylallyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1] comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. subset: gosubset_prok synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyltransferase activity" EXACT [] synonym: "diprenyltransferase activity" EXACT [EC:2.5.1.1] synonym: "DMAPP:IPP-dimethylallyltransferase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1] synonym: "trans-farnesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] xref: EC:2.5.1.1 xref: MetaCyc:GPPSYN-RXN xref: Reactome:8443 "dimethylallyltranstransferase activity" is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004162 name: dimethylnitrosamine demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah] synonym: "N-nitrosodimethylamine demethylase activity" EXACT [] is_a: GO:0032451 ! demethylase activity [Term] id: GO:0004163 name: diphosphomevalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23735] subset: gosubset_prok synonym: "5-pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" EXACT [EC:4.1.1.33] synonym: "mevalonate 5-diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate-5-pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonic acid decarboxylase activity" EXACT [EC:4.1.1.33] xref: EC:4.1.1.33 xref: KEGG:R01121 xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN xref: Reactome:8449 "diphosphomevalonate decarboxylase activity" xref: RHEA:23735 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004164 name: diphthine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98] subset: gosubset_prok synonym: "diphthine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" EXACT [EC:2.1.1.98] xref: EC:2.1.1.98 xref: MetaCyc:RXN-11370 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004165 name: dodecenoyl-CoA delta-isomerase activity namespace: molecular_function alt_id: GO:0008461 def: "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] subset: gosubset_prok synonym: "3,2-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "acetylene-allene isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3),Delta(2)-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3,Delta2-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.8] synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA D-isomerase activity" EXACT [] synonym: "dodecenoyl-CoA Delta-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] xref: EC:5.3.3.8 xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN xref: Reactome:8459 "dodecenoyl-CoA delta-isomerase activity" is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004166 name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function alt_id: GO:0004101 def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153] synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] xref: EC:2.4.1.153 xref: MetaCyc:2.4.1.153-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004167 name: dopachrome isomerase activity namespace: molecular_function alt_id: GO:0048059 def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13044] synonym: "DCF activity" EXACT [EC:5.3.3.12] synonym: "DCT activity" EXACT [EC:5.3.3.12] synonym: "dopachrome conversion activity" BROAD [] synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12] synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome delta-isomerase activity" EXACT [] synonym: "dopachrome delta7,Delta2-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome oxidoreductase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome rearranging enzyme activity" EXACT [EC:5.3.3.12] synonym: "dopachrome tautomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12] synonym: "L-dopachrome isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome-methyl ester tautomerase activity" EXACT [EC:5.3.3.12] synonym: "TRP activity" EXACT [EC:5.3.3.12] synonym: "TRP-1" RELATED [EC:5.3.3.12] synonym: "TRP-2" RELATED [EC:5.3.3.12] synonym: "TRP2" RELATED [EC:5.3.3.12] synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12] synonym: "tyrosinase-related protein 2 activity" EXACT [EC:5.3.3.12] xref: EC:5.3.3.12 xref: KEGG:R03673 xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN xref: RHEA:13044 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004168 name: dolichol kinase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108] synonym: "CTP:dolichol O-phosphotransferase activity" EXACT [EC:2.7.1.108] synonym: "dolichol phosphokinase activity" EXACT [EC:2.7.1.108] xref: EC:2.7.1.108 xref: MetaCyc:DOLICHOL-KINASE-RXN xref: Reactome:8470 "dolichol kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004169 name: dolichyl-phosphate-mannose-protein mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109] subset: gosubset_prok synonym: "dolichol phosphomannose-protein mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT [] synonym: "O-glycoside mannosyltransferase" BROAD [] synonym: "protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "protein O-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.109 xref: MetaCyc:2.4.1.109-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004170 name: dUTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23] subset: gosubset_prok synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP pyrophosphatase activity" EXACT [] synonym: "dUTPase activity" EXACT [EC:3.6.1.23] xref: EC:3.6.1.23 xref: MetaCyc:DUTP-PYROP-RXN xref: Reactome:8479 "dUTP diphosphatase activity" is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0004171 name: deoxyhypusine synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46] comment: This term was made obsolete because it represents a multistep reaction. synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED [] is_obsolete: true replaced_by: GO:0008612 replaced_by: GO:0034038 replaced_by: GO:0050983 [Term] id: GO:0004172 name: ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two molecular functions. is_obsolete: true consider: GO:0050488 [Term] id: GO:0004173 name: ecdysone O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate." [EC:2.3.1.139, RHEA:15220] synonym: "acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" EXACT [EC:2.3.1.139] xref: EC:2.3.1.139 xref: KEGG:R02375 xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN xref: RHEA:15220 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004174 name: electron-transferring-flavoprotein dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1] subset: gosubset_prok synonym: "electron transfer flavoprotein dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein Q oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein reductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "ETF-QO activity" EXACT [EC:1.5.5.1] synonym: "ETF-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] xref: EC:1.5.5.1 xref: MetaCyc:1.5.5.1-RXN xref: Reactome:8494 "electron-transferring-flavoprotein dehydrogenase activity" is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor [Term] id: GO:0004175 name: endopeptidase activity namespace: molecular_function alt_id: GO:0016809 def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "endoprotease activity" EXACT [] synonym: "proteasome endopeptidase activity" NARROW [] synonym: "proteinase" BROAD [] xref: Reactome:1793 "endopeptidase activity" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004176 name: ATP-dependent peptidase activity namespace: molecular_function alt_id: GO:0004280 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah] subset: gosubset_prok synonym: "ATP-dependent proteolysis" RELATED [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004177 name: aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.4.11 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004178 name: leucyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminopeptidase II" RELATED [EC:3.4.11.1] synonym: "cathepsin III" RELATED [EC:3.4.11.1] synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1] synonym: "FTBL proteins" RELATED [EC:3.4.11.1] synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1] synonym: "peptidase S activity" NARROW [EC:3.4.11.1] synonym: "proteinates FTBL" RELATED [EC:3.4.11.1] xref: EC:3.4.11.1 xref: MetaCyc:3.4.11.1-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004179 name: membrane alanyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2] synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2] synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2] synonym: "CD13" RELATED [EC:3.4.11.2] synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2] synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2] synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2] synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "peptidase E activity" BROAD [EC:3.4.11.2] synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2] xref: EC:3.4.11.2 xref: MetaCyc:3.4.11.2-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004180 name: carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004181 name: metallocarboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.4.17 xref: Reactome:8516 "metallocarboxypeptidase activity" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0008235 ! metalloexopeptidase activity [Term] id: GO:0004182 name: carboxypeptidase A activity namespace: molecular_function alt_id: GO:0008731 def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1] synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1] synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1] xref: EC:3.4.17.1 xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004183 name: carboxypeptidase E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase H activity" EXACT [] synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10] synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10] synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10] xref: EC:3.4.17.10 xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004184 name: lysine carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3] comment: This term was made obsolete because it represents a gene product. synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3] synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "bradykinase activity" EXACT [EC:3.4.17.3] synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3] synonym: "carboxypeptidase N activity" EXACT [] synonym: "CPase N" RELATED [EC:3.4.17.3] synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3] synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3] synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3] synonym: "kininase I activity" EXACT [EC:3.4.17.3] synonym: "kininase Ia" RELATED [EC:3.4.17.3] synonym: "lysine (arginine) carboxypeptidase activity" EXACT [] synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3] synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3] xref: EC:3.4.17.3 xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004185 name: serine-type carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] subset: gosubset_prok synonym: "serine carboxypeptidase activity" EXACT [] xref: EC:3.4.16 xref: Reactome:8533 "serine-type carboxypeptidase activity" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0070008 ! serine-type exopeptidase activity [Term] id: GO:0004186 name: carboxypeptidase C activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase Y activity" EXACT [EC:3.4.16.5] synonym: "cathepsin A activity" NARROW [EC:3.4.16.5] synonym: "deamidase" RELATED [EC:3.4.16.5] synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5] synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5] synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "vacuolar carboxypeptidase Y" NARROW [] xref: EC:3.4.16.5 xref: MetaCyc:3.4.16.5-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004187 name: carboxypeptidase D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6] synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6] synonym: "carboxypeptidase S1 activity" EXACT [EC:3.4.16.6] synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6] synonym: "CPDW-II" RELATED [EC:3.4.16.6] synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6] synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6] synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6] synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6] synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6] xref: EC:3.4.16.6 xref: MetaCyc:3.4.16.6-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004188 name: serine-type Pro-X carboxypeptidase activity namespace: molecular_function alt_id: GO:0008323 def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2] comment: This term was made obsolete because it represents a gene product. synonym: "aminoacylproline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW [] synonym: "lysosomal Pro-Xaa carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "PCP" RELATED [EC:3.4.16.2] synonym: "peptidylprolylamino acid carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2] synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2] xref: EC:3.4.16.2 xref: MetaCyc:3.4.16.2-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004189 name: tubulinyl-Tyr carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17] comment: This term was made obsolete because it represents a gene product. synonym: "brain I carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "carboxypeptidase-tubulin activity" EXACT [EC:3.4.17.17] synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17] synonym: "TTCPase activity" EXACT [EC:3.4.17.17] synonym: "tubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulin-tyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT [] synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] xref: EC:3.4.17.17 xref: MetaCyc:3.4.17.17-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004190 name: aspartic-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aspartic endopeptidase activity" EXACT [] synonym: "aspartic protease activity" EXACT [] synonym: "aspartyl protease activity" EXACT [] synonym: "carboxyl protease activity" EXACT [] xref: EC:3.4.23 xref: Reactome:1933 "aspartic-type endopeptidase activity" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070001 ! aspartic-type peptidase activity [Term] id: GO:0004191 name: barrierpepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35] comment: This term was made obsolete because it represents a gene product. synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35] synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35] synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35] xref: EC:3.4.23.35 xref: MetaCyc:3.4.23.35-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004192 name: cathepsin D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.23.5 xref: MetaCyc:3.4.23.5-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004193 name: cathepsin E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin D-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin D-type proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin E-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "EMAP" RELATED [EC:3.4.23.34] synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34] synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34] synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34] synonym: "SMP" RELATED [EC:3.4.23.34] xref: EC:3.4.23.34 xref: MetaCyc:3.4.23.34-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004194 name: pepsin A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1] comment: This term was made obsolete because it represents a gene product. synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1] synonym: "fundus-pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1] synonym: "P I" RELATED [EC:3.4.23.1] synonym: "P II" RELATED [EC:3.4.23.1] synonym: "pepsin activity" BROAD [EC:3.4.23.1] synonym: "pepsin D" RELATED [EC:3.4.23.1] synonym: "pepsin fortior" RELATED [EC:3.4.23.1] synonym: "pepsin R" RELATED [EC:3.4.23.1] xref: EC:3.4.23.1 xref: MetaCyc:3.4.23.1-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004195 name: renin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15] comment: This term was made obsolete because it represents a gene product. synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15] synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15] xref: EC:3.4.23.15 xref: MetaCyc:3.4.23.15-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004196 name: saccharopepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25] comment: This term was made obsolete because it represents a gene product. synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25] synonym: "PRA" RELATED [EC:3.4.23.25] synonym: "proteinase A" RELATED [EC:3.4.23.25] synonym: "proteinase yscA" RELATED [EC:3.4.23.25] synonym: "saccharomyces aspartic proteinase activity" EXACT [EC:3.4.23.25] synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25] synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25] synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25] synonym: "yeast proteinase A" RELATED [EC:3.4.23.25] xref: EC:3.4.23.25 xref: MetaCyc:3.4.23.25-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004197 name: cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "lysosomal cysteine-type endopeptidase" NARROW [] synonym: "thiol endopeptidase activity" EXACT [] xref: EC:3.4.22 xref: Reactome:4344 "cysteine-type endopeptidase activity" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0004198 name: calcium-dependent cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] subset: gosubset_prok synonym: "calpain activity" NARROW [] is_a: GO:0004197 ! cysteine-type endopeptidase activity [Term] id: GO:0004200 name: signaling (initiator) caspase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes biological process information. synonym: "signalling (initiator) caspase activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 consider: GO:0006915 [Term] id: GO:0004201 name: caspase-1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36] comment: This term was made obsolete because it represents a gene product. synonym: "ICE" BROAD [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004202 name: caspase-2 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004203 name: caspase-4 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004204 name: caspase-5 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004205 name: caspase-8 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004206 name: caspase-10 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004207 name: effector caspase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes biological process information. is_obsolete: true replaced_by: GO:0004197 consider: GO:0006915 [Term] id: GO:0004208 name: caspase-3 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004209 name: caspase-6 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004210 name: caspase-7 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004211 name: caspase-9 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004212 name: lysosomal cysteine-type endopeptidase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0004197 consider: GO:0005764 [Term] id: GO:0004213 name: cathepsin B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1] synonym: "cathepsin II" RELATED [EC:3.4.22.1] xref: EC:3.4.22.1 xref: MetaCyc:3.4.22.1-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004214 name: dipeptidyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin C activity" EXACT [EC:3.4.14.1] synonym: "cathepsin J activity" EXACT [EC:3.4.14.1] synonym: "DAP I" RELATED [EC:3.4.14.1] synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1] synonym: "dipeptidyl aminopeptidase I activity" EXACT [EC:3.4.14.1] synonym: "dipeptidyl transferase activity" EXACT [EC:3.4.14.1] xref: EC:3.4.14.1 xref: MetaCyc:3.4.14.1-RXN is_obsolete: true replaced_by: GO:0008234 replaced_by: GO:0008239 [Term] id: GO:0004215 name: cathepsin H activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16] comment: This term was made obsolete because it represents a gene product. synonym: "aleurain activity" EXACT [EC:3.4.22.16] synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" EXACT [EC:3.4.22.16] synonym: "cathepsin B3 activity" EXACT [EC:3.4.22.16] synonym: "cathepsin Ba" RELATED [EC:3.4.22.16] synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16] synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16] xref: EC:3.4.22.16 xref: MetaCyc:3.4.22.16-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004216 name: cathepsin K activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin O activity" EXACT [EC:3.4.22.38] synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38] synonym: "cathepsin X activity" EXACT [EC:3.4.22.38] xref: EC:3.4.22.38 xref: MetaCyc:3.4.22.38-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004217 name: cathepsin L activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15] comment: This term was made obsolete because it represents a gene product. synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15] xref: EC:3.4.22.15 xref: MetaCyc:3.4.22.15-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004218 name: cathepsin S activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.22.27 xref: MetaCyc:3.4.22.27-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004219 name: pyroglutamyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "5-oxoprolyl-peptidase activity" EXACT [EC:3.4.19.3] synonym: "L-pyroglutamyl peptide hydrolase activity" EXACT [EC:3.4.19.3] synonym: "L-pyrrolidonecarboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrase activity" EXACT [EC:3.4.19.3] synonym: "PYRase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamyl aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonecarboxylyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonyl peptidase activity" EXACT [EC:3.4.19.3] xref: EC:3.4.19.3 xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN is_obsolete: true replaced_by: GO:0008234 replaced_by: GO:0016920 [Term] id: GO:0004221 name: ubiquitin thiolesterase activity namespace: molecular_function alt_id: GO:0008577 def: "Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15] comment: Note that this term is distinguished from 'ubiquitin-specific protease activity ; GO:0004843' in that it specifically refers to hydrolysis of thiolester bonds, but encompasses the removal of any substrate attached to ubiquitin via a thiolester bond. subset: gosubset_prok synonym: "ubiquitin C-terminal hydrolase activity" RELATED [] synonym: "ubiquitin carboxy-terminal esterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin carboxy-terminal hydrolase activity" RELATED [EC:3.1.2.15] synonym: "ubiquitin thioesterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin-C-terminal-thioester hydrolase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitinyl hydrolase 1 activity" NARROW [] xref: EC:3.1.2.15 xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0004222 name: metalloendopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "metalloendoprotease activity" EXACT [GOC:mah] synonym: "metalloendoproteinase activity" EXACT [GOC:mah] xref: EC:3.4.24 xref: Reactome:1791 "metalloendopeptidase activity" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008237 ! metallopeptidase activity [Term] id: GO:0004226 name: Gly-X carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4] synonym: "carboxypeptidase S activity" EXACT [EC:3.4.17.4] synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "peptidase alpha" RELATED [EC:3.4.17.4] synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4] xref: EC:3.4.17.4 xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004228 name: gelatinase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24] comment: This term was made obsolete because it represents a gene product. synonym: "3/4 collagenase activity" EXACT [EC:3.4.24.24] synonym: "72 kDa gelatinase type A" RELATED [EC:3.4.24.24] synonym: "72-kDa gelatinase activity" NARROW [EC:3.4.24.24] synonym: "collagenase IV" RELATED [EC:3.4.24.24] synonym: "collagenase type IV" RELATED [EC:3.4.24.24] synonym: "matrix metalloproteinase 2 activity" EXACT [EC:3.4.24.24] synonym: "matrix metalloproteinase 5" RELATED [EC:3.4.24.24] synonym: "MMP 2" RELATED [EC:3.4.24.24] synonym: "MMP-2" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24] synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24] synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24] xref: EC:3.4.24.24 xref: MetaCyc:3.4.24.24-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004229 name: gelatinase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35] comment: This term was made obsolete because it represents a gene product. synonym: "92-kDa gelatinase activity" NARROW [EC:3.4.24.35] synonym: "92-kDa type IV collagenase activity" NARROW [EC:3.4.24.35] synonym: "95 kDa type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.35] synonym: "collagenase IV" RELATED [EC:3.4.24.35] synonym: "collagenase type IV" RELATED [EC:3.4.24.35] synonym: "gelatinase MMP 9" RELATED [EC:3.4.24.35] synonym: "macrophage gelatinase activity" NARROW [EC:3.4.24.35] synonym: "matrix metalloproteinase 9 activity" EXACT [EC:3.4.24.35] synonym: "MMP 9" RELATED [EC:3.4.24.35] synonym: "MMP-9" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35] synonym: "type V collagenase activity" EXACT [EC:3.4.24.35] xref: EC:3.4.24.35 xref: MetaCyc:3.4.24.35-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004230 name: glutamyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminopeptidase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A2" RELATED [EC:3.4.11.7] synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7] synonym: "aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "Ca2+-activated glutamate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "glutamyl peptidase activity" EXACT [EC:3.4.11.7] synonym: "L-aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7] xref: EC:3.4.11.7 xref: MetaCyc:3.4.11.7-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004231 name: insulysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "IDE" RELATED [EC:3.4.24.56] synonym: "insulin protease activity" EXACT [EC:3.4.24.56] synonym: "insulin proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading enzyme activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading neutral proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-glucagon protease activity" EXACT [EC:3.4.24.56] synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56] synonym: "insulinase activity" EXACT [EC:3.4.24.56] synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56] xref: EC:3.4.24.56 xref: MetaCyc:3.4.24.56-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004232 name: interstitial collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 1" EXACT [] synonym: "MMP-1" EXACT [] synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7] xref: EC:3.4.24.7 xref: MetaCyc:3.4.24.7-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004234 name: macrophage elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65] comment: This term was made obsolete because it represents a gene product. synonym: "human macrophage metalloelastase (HME)" EXACT [EC:3.4.24.65] synonym: "matrix metalloproteinase 12 activity" EXACT [EC:3.4.24.65] synonym: "metalloelastase activity" EXACT [EC:3.4.24.65] synonym: "metalloesterase activity" EXACT [] synonym: "MMP-12" EXACT [] xref: EC:3.4.24.65 xref: MetaCyc:3.4.24.65-RXN is_obsolete: true replaced_by: GO:0004175 replaced_by: GO:0004222 [Term] id: GO:0004235 name: matrilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23] comment: This term was made obsolete because it represents a gene product. synonym: "matrin activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase 7 activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase pump 1" RELATED [EC:3.4.24.23] synonym: "metalloproteinase pump-1" RELATED [EC:3.4.24.23] synonym: "MMP" RELATED [EC:3.4.24.23] synonym: "MMP 7" RELATED [EC:3.4.24.23] synonym: "MMP-7" EXACT [] synonym: "PUMP" RELATED [EC:3.4.24.23] synonym: "PUMP-1 activity" NARROW [EC:3.4.24.23] synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23] synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23] synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23] synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23] xref: EC:3.4.24.23 xref: MetaCyc:3.4.24.23-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004237 name: membrane dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminodipeptidase activity" EXACT [EC:3.4.13.19] synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19] synonym: "dehydropeptidase I activity" EXACT [EC:3.4.13.19] synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19] synonym: "dipeptidyl hydrolase activity" EXACT [EC:3.4.13.19] synonym: "DPH I activity" NARROW [EC:3.4.13.19] synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "MDP" RELATED [EC:3.4.13.19] synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19] synonym: "nonspecific dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19] xref: EC:3.4.13.19 xref: MetaCyc:3.4.13.19-RXN is_obsolete: true replaced_by: GO:0008235 replaced_by: GO:0016805 [Term] id: GO:0004238 name: meprin A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18] comment: This term was made obsolete because it represents a gene product. synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.18] synonym: "meprin" RELATED [EC:3.4.24.18] synonym: "meprin-a" RELATED [EC:3.4.24.18] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PPH" RELATED [EC:3.4.24.18] xref: EC:3.4.24.18 xref: MetaCyc:3.4.24.18-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004239 name: methionyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "L-methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "MAP" RELATED [EC:3.4.11.18] synonym: "methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "peptidase M activity" EXACT [EC:3.4.11.18] xref: EC:3.4.11.18 xref: MetaCyc:3.4.11.18-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 consider: GO:0070084 [Term] id: GO:0004240 name: mitochondrial processing peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-mitochondrial processing peptidase" NARROW [] synonym: "beta-mitochondrial processing peptidase" NARROW [] synonym: "matrix peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing proteinase" RELATED [EC:3.4.24.64] synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT [EC:3.4.24.64] synonym: "MPP" EXACT [] synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64] synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64] xref: EC:3.4.24.64 xref: MetaCyc:3.4.24.64-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004241 name: alpha-mitochondrial processing peptidase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-MPP" EXACT [] is_obsolete: true consider: GO:0004222 consider: GO:0005739 [Term] id: GO:0004242 name: beta-mitochondrial processing peptidase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "beta-MPP" EXACT [] is_obsolete: true consider: GO:0004222 consider: GO:0005739 [Term] id: GO:0004243 name: mitochondrial intermediate peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59] comment: This term was made obsolete because it represents a gene product. synonym: "MIP" BROAD [] synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59] xref: EC:3.4.24.59 xref: MetaCyc:3.4.24.59-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004244 name: mitochondrial inner membrane peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769] comment: This term was made obsolete because it represents a gene product. synonym: "IMP" BROAD [] xref: EC:3.4.99.- is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0004245 name: neprilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "CALLA" RELATED [EC:3.4.24.11] synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [EC:3.4.24.11] synonym: "CALLA antigen" RELATED [EC:3.4.24.11] synonym: "CALLA glycoprotein" RELATED [EC:3.4.24.11] synonym: "CALLA glycoproteins" RELATED [EC:3.4.24.11] synonym: "CD10" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [EC:3.4.24.11] synonym: "endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.11] synonym: "enkephalinase activity" EXACT [EC:3.4.24.11] synonym: "kidney-brush-border neutral endopeptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral peptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral proteinase activity" NARROW [EC:3.4.24.11] synonym: "membrane metalloendopeptidase activity" NARROW [EC:3.4.24.11] synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11] synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11] xref: EC:3.4.24.11 xref: MetaCyc:3.4.24.11-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004246 name: peptidyl-dipeptidase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "ACE activity" BROAD [] synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1] synonym: "angiotensin I-converting enzyme activity" EXACT [EC:3.4.15.1] synonym: "carboxycathepsin activity" EXACT [EC:3.4.15.1] synonym: "DCP" RELATED [EC:3.4.15.1] synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1] synonym: "dipeptidyl carboxypeptidase I activity" EXACT [EC:3.4.15.1] synonym: "endothelial cell peptidyl dipeptidase activity" EXACT [EC:3.4.15.1] synonym: "kininase II activity" EXACT [EC:3.4.15.1] synonym: "PDH" RELATED [EC:3.4.15.1] synonym: "peptidase P activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptidase I activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyl-dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyldipeptide hydrolase activity" EXACT [EC:3.4.15.1] xref: EC:3.4.15.1 xref: MetaCyc:3.4.15.1-RXN is_obsolete: true replaced_by: GO:0008237 replaced_by: GO:0008241 [Term] id: GO:0004247 name: saccharolysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [EC:3.4.24.37] comment: This term was made obsolete because it represents a gene product. synonym: "oligopeptidase yscD activity" NARROW [EC:3.4.24.37] synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37] synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37] synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37] xref: EC:3.4.24.37 xref: MetaCyc:3.4.24.37-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004248 name: stromelysin 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17] comment: This term was made obsolete because it represents a gene product. synonym: "collagen-activating protein" RELATED [EC:3.4.24.17] synonym: "collagenase activating protein" RELATED [EC:3.4.24.17] synonym: "matrix metalloproteinase 3 activity" EXACT [EC:3.4.24.17] synonym: "MMP-3" EXACT [] synonym: "neutral proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "procollagenase activator" RELATED [EC:3.4.24.17] synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "stromelysin" RELATED [EC:3.4.24.17] synonym: "transin activity" EXACT [EC:3.4.24.17] xref: EC:3.4.24.17 xref: MetaCyc:3.4.24.17-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004249 name: stromelysin 3 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 11" EXACT [] synonym: "MMP-11" EXACT [] xref: EC:3.4.24.- is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004250 name: aminopeptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminopeptidase III activity" EXACT [EC:3.4.11.22] synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22] synonym: "leucine aminopeptidase IV activity" EXACT [EC:3.4.11.22] synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22] synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22] xref: EC:3.4.11.22 xref: MetaCyc:3.4.11.22-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004251 name: X-Pro dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "gamma-peptidase activity" EXACT [EC:3.4.13.9] synonym: "imidodipeptidase activity" EXACT [EC:3.4.13.9] synonym: "peptidase D" RELATED [EC:3.4.13.9] synonym: "prolidase activity" EXACT [EC:3.4.13.9] synonym: "proline dipeptidase activity" EXACT [EC:3.4.13.9] synonym: "Xaa-Pro dipeptidase activity" EXACT [] xref: EC:3.4.13.9 xref: MetaCyc:3.4.13.9-RXN is_obsolete: true replaced_by: GO:0008235 replaced_by: GO:0016805 [Term] id: GO:0004252 name: serine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] subset: gosubset_prok synonym: "blood coagulation factor activity" RELATED [] xref: EC:3.4.21 xref: Reactome:1683 "serine-type endopeptidase activity" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008236 ! serine-type peptidase activity [Term] id: GO:0004253 name: gamma-renin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.21.54 xref: MetaCyc:3.4.21.54-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004254 name: acylaminoacyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1] subset: gosubset_prok synonym: "acylamino-acid-releasing enzyme activity" EXACT [EC:3.4.19.1] synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1] xref: EC:3.4.19.1 xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004258 name: vacuolar carboxypeptidase Y namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0004185 consider: GO:0005773 [Term] id: GO:0004261 name: cathepsin G activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20] comment: This term was made obsolete because it represents a gene product. synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20] synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20] xref: EC:3.4.21.20 xref: MetaCyc:3.4.21.20-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004262 name: cerevisin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48] comment: This term was made obsolete because it represents a gene product. synonym: "baker's yeast proteinase B" RELATED [EC:3.4.21.48] synonym: "brewer's yeast proteinase" NARROW [EC:3.4.21.48] synonym: "peptidase beta" RELATED [EC:3.4.21.48] synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48] synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48] xref: EC:3.4.21.48 xref: MetaCyc:3.4.21.48-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004263 name: chymotrypsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alpha-chymar" RELATED [EC:3.4.21.1] synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin A" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin activity" NARROW [EC:3.4.21.1] synonym: "avazyme" RELATED [EC:3.4.21.1] synonym: "chymar" RELATED [EC:3.4.21.1] synonym: "chymotest" RELATED [EC:3.4.21.1] synonym: "chymotrypsin A activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsin B activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1] synonym: "enzeon" RELATED [EC:3.4.21.1] synonym: "quimar" RELATED [EC:3.4.21.1] synonym: "quimotrase activity" EXACT [EC:3.4.21.1] xref: EC:3.4.21.1 xref: MetaCyc:3.4.21.1-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004274 name: dipeptidyl-peptidase IV activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-peptide hydrolase activity" EXACT [EC:3.4.14.5] synonym: "DPP IV activity" EXACT [EC:3.4.14.5] synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5] synonym: "Gly-Pro naphthylamidase activity" EXACT [EC:3.4.14.5] synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5] synonym: "glycylproline aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "pep X" RELATED [EC:3.4.14.5] synonym: "post-proline dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5] synonym: "X-PDAP" RELATED [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] xref: EC:3.4.14.5 xref: MetaCyc:3.4.14.5-RXN is_obsolete: true replaced_by: GO:0008236 replaced_by: GO:0008239 [Term] id: GO:0004275 name: enteropeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [EC:3.4.21.9] comment: This term was made obsolete because it represents a gene product. synonym: "enterokinase activity" RELATED [EC:3.4.21.9] xref: EC:3.4.21.9 xref: MetaCyc:3.4.21.9-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004276 name: furin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75] comment: This term was made obsolete because it represents a gene product. synonym: "dibasic processing enzyme activity" EXACT [EC:3.4.21.75] synonym: "PACE" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid cleaving enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid converting enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.4.21.75] synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75] synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75] synonym: "SPC3" RELATED [EC:3.4.21.75] xref: EC:3.4.21.75 xref: MetaCyc:3.4.21.75-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004277 name: granzyme A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78] comment: This term was made obsolete because it represents a gene product. synonym: "CTLA3" RELATED [EC:3.4.21.78] synonym: "cytotoxic T lymphocyte serine protease" NARROW [EC:3.4.21.78] synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [EC:3.4.21.78] synonym: "HuTPS" RELATED [EC:3.4.21.78] synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78] synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78] synonym: "TSP-1" RELATED [EC:3.4.21.78] xref: EC:3.4.21.78 xref: MetaCyc:3.4.21.78-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004278 name: granzyme B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79] comment: This term was made obsolete because it represents a gene product. synonym: "CCP1 proteinase" NARROW [EC:3.4.21.79] synonym: "CCPII" RELATED [EC:3.4.21.79] synonym: "CTLA1" RELATED [EC:3.4.21.79] synonym: "cytotoxic cell proteinase-1" RELATED [EC:3.4.21.79] synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79] synonym: "granzyme G" RELATED [EC:3.4.21.79] synonym: "granzyme H" RELATED [EC:3.4.21.79] xref: EC:3.4.21.79 xref: MetaCyc:3.4.21.79-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004281 name: pancreatic elastase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71] comment: This term was made obsolete because it represents a gene product. synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71] xref: EC:3.4.21.71 xref: MetaCyc:3.4.21.71-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004283 name: plasmin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7] comment: This term was made obsolete because it represents a gene product. synonym: "actase activity" EXACT [EC:3.4.21.7] synonym: "fibrinase activity" EXACT [EC:3.4.21.7] synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7] synonym: "serum tryptase activity" EXACT [EC:3.4.21.7] synonym: "thrombolysin" RELATED [EC:3.4.21.7] xref: EC:3.4.21.7 xref: MetaCyc:3.4.21.7-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004284 name: acrosin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [EC:3.4.21.10] comment: This term was made obsolete because it represents a gene product. synonym: "acrosin amidase activity" EXACT [EC:3.4.21.10] synonym: "acrosomal protease activity" EXACT [EC:3.4.21.10] synonym: "acrosomal proteinase activity" EXACT [EC:3.4.21.10] synonym: "acrozonase activity" EXACT [EC:3.4.21.10] synonym: "alpha-acrosin" RELATED [EC:3.4.21.10] synonym: "beta-acrosin" RELATED [EC:3.4.21.10] synonym: "psi-acrosin" RELATED [EC:3.4.21.10] xref: EC:3.4.21.10 xref: MetaCyc:3.4.21.10-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004285 name: proprotein convertase 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93] comment: This term was made obsolete because it represents a gene product. synonym: "NEC 1 activity" NARROW [EC:3.4.21.93] synonym: "neuroendocrine convertase 1 activity" NARROW [EC:3.4.21.93] synonym: "PC1 activity" NARROW [EC:3.4.21.93] synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93] synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93] xref: EC:3.4.21.93 xref: MetaCyc:3.4.21.93-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004286 name: proprotein convertase 2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94] comment: This term was made obsolete because it represents a gene product. synonym: "NEC 2 activity" NARROW [EC:3.4.21.94] synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94] synonym: "PC2 activity" NARROW [EC:3.4.21.94] synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94] xref: EC:3.4.21.94 xref: MetaCyc:3.4.21.94-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004287 name: prolyl oligopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [EC:3.4.21.26] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "endoprolylpeptidase activity" EXACT [EC:3.4.21.26] synonym: "post-proline cleaving enzyme activity" EXACT [EC:3.4.21.26] synonym: "post-proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26] xref: EC:3.4.21.26 xref: MetaCyc:3.4.21.26-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004289 name: subtilase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok xref: EC:3.4.21.- is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004290 name: kexin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61] comment: This term was made obsolete because it represents a gene product. synonym: "andrenorphin-Gly-generating enzyme" RELATED [EC:3.4.21.61] synonym: "endoproteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "gene KEX2 dibasic proteinase" NARROW [EC:3.4.21.61] synonym: "Kex 2p proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 endopeptidase" NARROW [EC:3.4.21.61] synonym: "Kex2 endoprotease" NARROW [EC:3.4.21.61] synonym: "Kex2 endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 protease" NARROW [EC:3.4.21.61] synonym: "Kex2 proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like precursor protein processing endoprotease" NARROW [EC:3.4.21.61] synonym: "paired-basic endopeptidase activity" EXACT [EC:3.4.21.61] synonym: "prohormone-processing endoprotease activity" RELATED [EC:3.4.21.61] synonym: "prohormone-processing KEX2 proteinase" NARROW [EC:3.4.21.61] synonym: "prohormone-processing proteinase activity" EXACT [EC:3.4.21.61] synonym: "protease KEX2" RELATED [EC:3.4.21.61] synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61] synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61] synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61] xref: EC:3.4.21.61 xref: MetaCyc:3.4.21.61-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004291 name: subtilisin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alcalase 0.6L" RELATED [EC:3.4.21.62] synonym: "alcalase 2.5L" RELATED [EC:3.4.21.62] synonym: "alcalase activity" EXACT [EC:3.4.21.62] synonym: "ALK-enzyme" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase A" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase B" RELATED [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase activity" EXACT [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase bioprase activity" EXACT [EC:3.4.21.62] synonym: "bioprase AL 15" RELATED [EC:3.4.21.62] synonym: "bioprase APL 30" RELATED [EC:3.4.21.62] synonym: "colistinase activity" EXACT [EC:3.4.21.62] synonym: "esperase activity" EXACT [EC:3.4.21.62] synonym: "genenase I" RELATED [EC:3.4.21.62] synonym: "kazusase activity" EXACT [EC:3.4.21.62] synonym: "maxatase activity" EXACT [EC:3.4.21.62] synonym: "opticlean" RELATED [EC:3.4.21.62] synonym: "orientase 10B" RELATED [EC:3.4.21.62] synonym: "protease S" RELATED [EC:3.4.21.62] synonym: "protease VIII" RELATED [EC:3.4.21.62] synonym: "protease XXVII" RELATED [EC:3.4.21.62] synonym: "protin A 3L" RELATED [EC:3.4.21.62] synonym: "savinase 16.0L" RELATED [EC:3.4.21.62] synonym: "savinase 32.0 L EX" RELATED [EC:3.4.21.62] synonym: "savinase 4.0T" RELATED [EC:3.4.21.62] synonym: "savinase 8.0L" RELATED [EC:3.4.21.62] synonym: "savinase activity" EXACT [EC:3.4.21.62] synonym: "SP 266" RELATED [EC:3.4.21.62] synonym: "subtilisin BL" RELATED [EC:3.4.21.62] synonym: "subtilisin DY" RELATED [EC:3.4.21.62] synonym: "subtilisin E" RELATED [EC:3.4.21.62] synonym: "subtilisin GX" RELATED [EC:3.4.21.62] synonym: "subtilisin J" RELATED [EC:3.4.21.62] synonym: "subtilisin S41" RELATED [EC:3.4.21.62] synonym: "subtilisin sendai" RELATED [EC:3.4.21.62] synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62] synonym: "superase activity" EXACT [EC:3.4.21.62] synonym: "thermoase" BROAD [EC:3.4.21.62] synonym: "thermoase PC 10" RELATED [EC:3.4.21.62] xref: EC:3.4.21.62 xref: MetaCyc:3.4.21.62-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004293 name: tissue kallikrein activity namespace: molecular_function alt_id: GO:0004279 def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35] comment: This term was made obsolete because it represents a gene product. synonym: "bradykininogenase" BROAD [EC:3.4.21.35] synonym: "callicrein" RELATED [EC:3.4.21.35] synonym: "depot-padutin" RELATED [EC:3.4.21.35] synonym: "dilminal D" RELATED [EC:3.4.21.35] synonym: "glandular kallikrein activity" RELATED [EC:3.4.21.35] synonym: "glumorin" RELATED [EC:3.4.21.35] synonym: "kallidinogenase" BROAD [EC:3.4.21.35] synonym: "kallikrein" RELATED [EC:3.4.21.35] synonym: "kidney kallikrein" RELATED [EC:3.4.21.35] synonym: "kininogenase" BROAD [EC:3.4.21.35] synonym: "kininogenin activity" RELATED [EC:3.4.21.35] synonym: "onokrein P" RELATED [EC:3.4.21.35] synonym: "padreatin" RELATED [EC:3.4.21.35] synonym: "padutin" RELATED [EC:3.4.21.35] synonym: "pancreatic kallikrein" RELATED [EC:3.4.21.35] synonym: "salivary kallikrein" RELATED [EC:3.4.21.35] synonym: "submandibular kallikrein" RELATED [EC:3.4.21.35] synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35] synonym: "urinary kallikrein" RELATED [EC:3.4.21.35] synonym: "urokallikrein" RELATED [EC:3.4.21.35] xref: EC:3.4.21.35 xref: MetaCyc:3.4.21.35-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004294 name: tripeptidyl-peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10] comment: This term was made obsolete because it represents a gene product. synonym: "TPP" RELATED [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10] xref: EC:3.4.14.10 xref: MetaCyc:3.4.14.10-RXN is_obsolete: true replaced_by: GO:0008240 [Term] id: GO:0004295 name: trypsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [EC:3.4.21.4] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alpha-trypsin activity" NARROW [EC:3.4.21.4] synonym: "beta-trypsin activity" NARROW [EC:3.4.21.4] synonym: "cocoonase activity" EXACT [EC:3.4.21.4] synonym: "parenzyme" RELATED [EC:3.4.21.4] synonym: "parenzymol" RELATED [EC:3.4.21.4] synonym: "pseudotrypsin" RELATED [EC:3.4.21.4] synonym: "sperm receptor hydrolase activity" EXACT [EC:3.4.21.4] synonym: "tripcellim" RELATED [EC:3.4.21.4] synonym: "tryptar" RELATED [EC:3.4.21.4] synonym: "trypure" RELATED [EC:3.4.21.4] xref: EC:3.4.21.4 xref: MetaCyc:3.4.21.4-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004298 name: threonine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "26S protease" RELATED [EC:3.4.25] synonym: "alkaline protease" RELATED [EC:3.4.25] synonym: "ingensin" RELATED [EC:3.4.25] synonym: "large multicatalytic protease" NARROW [EC:3.4.25] synonym: "lens neutral proteinase" NARROW [EC:3.4.25] synonym: "MCP" RELATED [EC:3.4.25] synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25] synonym: "multicatalytic proteinase" NARROW [EC:3.4.25] synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25] synonym: "prosome" RELATED [EC:3.4.25] synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25] synonym: "threonine endopeptidase activity" EXACT [] synonym: "tricorn protease" NARROW [EC:3.4.25] synonym: "tricorn proteinase" NARROW [EC:3.4.25] xref: EC:3.4.25 is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070003 ! threonine-type peptidase activity [Term] id: GO:0004299 name: proteasome endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity." [EC:3.4.25.1] comment: This term was made obsolete because it mentions a component term in the text string. synonym: "multicatalytic endopeptidase" RELATED [] synonym: "proteasome" RELATED [] synonym: "proteasome endopeptidase complex" RELATED [] is_obsolete: true consider: GO:0004175 consider: GO:0008233 [Term] id: GO:0004300 name: enoyl-CoA hydratase activity namespace: molecular_function alt_id: GO:0016510 def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17] subset: gosubset_prok synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.17] synonym: "2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "2-octenoyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "acyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacid dehydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacyl-CoA dehydrase activity" EXACT [EC:4.2.1.17] synonym: "crotonyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "D-3-hydroxyacyl-CoA dehydratase" BROAD [EC:4.2.1.17] synonym: "ECH" RELATED [EC:4.2.1.17] synonym: "enol-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (L)" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "hydratase, enoyl coenzyme A" EXACT [EC:4.2.1.17] synonym: "short chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "short-chain enoyl-CoA hydratase activity" EXACT [] synonym: "trans-2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17] xref: EC:4.2.1.17 xref: MetaCyc:ENOYL-COA-HYDRAT-RXN xref: Reactome:10287 "enoyl-CoA hydratase activity" xref: UM-BBD_enzymeID:e0014 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004301 name: epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10] subset: gosubset_prok synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "cytosolic epoxide hydrolase activity" EXACT [EC:3.3.2.10] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "sEH" RELATED [EC:3.3.2.10] synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10] synonym: "trans-stilbene oxide hydrolase activity" EXACT [EC:3.3.2.10] xref: EC:3.3.2.10 xref: MetaCyc:3.3.2.10-RXN xref: UM-BBD_enzymeID:e0397 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0004303 name: estradiol 17-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] synonym: "17-beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62] synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62] synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-HSD" RELATED [EC:1.1.1.62] synonym: "17beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62] synonym: "estradiol 17beta-dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.62] synonym: "estrogen 17-oxidoreductase activity" EXACT [EC:1.1.1.62] xref: EC:1.1.1.62 xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN xref: Reactome:10289 "estradiol 17-beta-dehydrogenase activity" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004304 name: estrone sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4] synonym: "estrogen sulphotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrone sulphotransferase activity" EXACT [] synonym: "oestrogen sulphotransferase activity" EXACT [EC:2.8.2.4] xref: EC:2.8.2.4 xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN xref: Reactome:10293 "estrone sulfotransferase activity" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004305 name: ethanolamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine." [EC:2.7.1.82, RHEA:13072] synonym: "ATP:ethanolamine O-phosphotransferase activity" EXACT [EC:2.7.1.82] synonym: "ethanolamine kinase (phosphorylating)" EXACT [EC:2.7.1.82] synonym: "ethanolamine phosphokinase activity" EXACT [EC:2.7.1.82] xref: EC:2.7.1.82 xref: KEGG:R01468 xref: MetaCyc:ETHANOLAMINE-KINASE-RXN xref: RHEA:13072 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004306 name: ethanolamine-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14] synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "ET" RELATED [EC:2.7.7.14] synonym: "ethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT [] synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14] xref: EC:2.7.7.14 xref: MetaCyc:2.7.7.14-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004307 name: ethanolaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1] synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "CDPethanolamine diglyceride phosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "EPT" RELATED [EC:2.7.8.1] synonym: "phosphorylethanolamine-glyceride transferase activity" EXACT [EC:2.7.8.1] xref: EC:2.7.8.1 xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0004308 name: exo-alpha-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18] subset: gosubset_prok synonym: "acetylneuraminidase activity" EXACT [EC:3.2.1.18] synonym: "acetylneuraminyl hydrolase activity" EXACT [EC:3.2.1.18] synonym: "alpha-neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "N-acylneuraminate glycohydrolase activity" EXACT [EC:3.2.1.18] synonym: "neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "sialidase activity" EXACT [EC:3.2.1.18] xref: EC:3.2.1.18 xref: MetaCyc:3.2.1.18-RXN xref: Reactome:10303 "exo-alpha-sialidase activity" is_a: GO:0016997 ! alpha-sialidase activity [Term] id: GO:0004309 name: exopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11] subset: gosubset_prok synonym: "acid phosphoanhydride phosphohydrolase activity" EXACT [EC:3.6.1.11] synonym: "exopolypase activity" EXACT [EC:3.6.1.11] synonym: "Gra-Pase activity" EXACT [EC:3.6.1.11] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11] synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11] xref: EC:3.6.1.11 xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004310 name: farnesyl-diphosphate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21] comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. subset: gosubset_prok synonym: "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity" EXACT [EC:2.5.1.21] synonym: "presqualene synthase activity" EXACT [EC:2.5.1.21] synonym: "presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21] xref: EC:2.5.1.21 xref: MetaCyc:2.5.1.21-RXN xref: Reactome:10334 "farnesyl-diphosphate farnesyltransferase activity" is_a: GO:0004311 ! farnesyltranstransferase activity [Term] id: GO:0004311 name: farnesyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29, RHEA:17656] subset: gosubset_prok synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29] synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [EC:2.5.1.29] xref: EC:2.5.1.29 xref: KEGG:R02061 xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN xref: RHEA:17656 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004312 name: fatty acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] subset: gosubset_prok synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85] synonym: "fatty-acid synthase activity" EXACT [] xref: EC:2.3.1.85 xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN xref: Reactome:6069 "fatty acid synthase activity" is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0004313 name: [acyl-carrier-protein] S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38] synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT [] synonym: "ACAT activity" BROAD [EC:2.3.1.38] synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" EXACT [EC:2.3.1.38] synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP S-acetyltransferase activity" EXACT [] synonym: "ACPacetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38] xref: EC:2.3.1.38 xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016418 ! S-acetyltransferase activity [Term] id: GO:0004314 name: [acyl-carrier-protein] S-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39] subset: gosubset_prok synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT [] synonym: "ACP S-malonyltransferase activity" EXACT [] synonym: "acyl carrier protein malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl carrier proteinmalonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "FabD" RELATED [EC:2.3.1.39] synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39] synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39] synonym: "malonyl-CoA-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:ACP transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:AcpM transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "MAT" RELATED [EC:2.3.1.39] synonym: "MCAT activity" EXACT [EC:2.3.1.39] xref: EC:2.3.1.39 xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016419 ! S-malonyltransferase activity [Term] id: GO:0004315 name: 3-oxoacyl-[acyl-carrier-protein] synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41] subset: gosubset_prok synonym: "3-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT [] synonym: "3-oxoacyl-ACP synthase activity" EXACT [] synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl:ACP synthase I" RELATED [EC:2.3.1.41] synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthase I activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" RELATED [EC:2.3.1.41] synonym: "beta-ketoacylsynthase activity" EXACT [EC:2.3.1.41] synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "FabB" RELATED [EC:2.3.1.41] synonym: "FabF1" RELATED [EC:2.3.1.41] synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "KAS I activity" NARROW [EC:2.3.1.41] synonym: "KASI" RELATED [EC:2.3.1.41] synonym: "ketoacyl-ACP synthase activity" EXACT [] xref: EC:2.3.1.41 xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN is_a: GO:0004312 ! fatty acid synthase activity [Term] id: GO:0004316 name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] subset: gosubset_prok synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.100] synonym: "3-ketoacyl acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT [] synonym: "3-oxoacyl-ACP reductase activity" EXACT [] synonym: "3-oxoacyl-ACPreductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl thioester reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-ACP reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT [EC:1.1.1.100] xref: EC:1.1.1.100 xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004317 name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.61] synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmitoyl thioester dehydratase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmityl-ACP dehydrase activity" EXACT [EC:4.2.1.61] synonym: "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.61] synonym: "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] xref: EC:4.2.1.61 xref: KEGG:R04462 xref: MetaCyc:4.2.1.61-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0004318 name: enoyl-[acyl-carrier-protein] reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9] subset: gosubset_prok synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" EXACT [EC:1.3.1.9] synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-ACP reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.3.1.9] synonym: "NADH-enoyl acyl carrier protein reductase activity" EXACT [EC:1.3.1.9] synonym: "NADH-specific enoyl-ACP reductase activity" EXACT [EC:1.3.1.9] xref: EC:1.3.1.9 xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004319 name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10] subset: gosubset_prok synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl acyl-carrier-protein reductase activity" EXACT [EC:1.3.1.10] synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" EXACT [EC:1.3.1.10] synonym: "NADPH 2-enoyl Co A reductase activity" EXACT [EC:1.3.1.10] synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.10] xref: EC:1.3.1.10 xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004320 name: oleoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14] subset: gosubset_prok synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "oleoyl-ACP hydrolase activity" EXACT [] synonym: "oleoyl-ACP thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl carrier protein thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14] xref: EC:3.1.2.14 xref: MetaCyc:3.1.2.14-RXN xref: MetaCyc:PWY-5142 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0004321 name: fatty-acyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" EXACT [EC:2.3.1.86] synonym: "fatty acyl CoA synthase activity" EXACT [GOC:curators] synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86] xref: EC:2.3.1.86 xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0004322 name: ferroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] subset: gosubset_prok synonym: "caeruloplasmin" RELATED [EC:1.16.3.1] synonym: "ceruloplasmin activity" NARROW [EC:1.16.3.1] synonym: "Fe(II):oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferro:O2 oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferroxidase I" RELATED [EC:1.16.3.1] synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "iron(II): oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "multicopper ferroxidase iron transport mediator activity" NARROW [] xref: EC:1.16.3.1 xref: MetaCyc:RXN0-1483 xref: Reactome:10387 "ferroxidase activity" is_a: GO:0016724 ! oxidoreductase activity, oxidizing metal ions, oxygen as acceptor [Term] id: GO:0004323 name: multicopper ferroxidase iron transport mediator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0004322 consider: GO:0005381 [Term] id: GO:0004324 name: ferredoxin-NADP+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [EC:1.18.1.2, GOC:kd] comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'. subset: gosubset_prok synonym: "ferredoxin-NADP oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-NADP reductase activity" EXACT [] synonym: "ferredoxin-NADP-oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-TPN reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADP:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADPH:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" EXACT [EC:1.18.1.2] synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.2 xref: MetaCyc:1.18.1.2-RXN is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0004325 name: ferrochelatase activity namespace: molecular_function def: "Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [EC:4.99.1.1, RHEA:22587] subset: gosubset_prok synonym: "ferro-protoporphyrin chelatase activity" EXACT [EC:4.99.1.1] synonym: "heme synthase activity" EXACT [EC:4.99.1.1] synonym: "heme synthetase activity" EXACT [EC:4.99.1.1] synonym: "iron chelatase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferrolyase activity" EXACT [EC:4.99.1.1] xref: EC:4.99.1.1 xref: KEGG:R00310 xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN xref: Reactome:10394 "ferrochelatase activity" xref: RHEA:22587 is_a: GO:0016829 ! lyase activity [Term] id: GO:0004326 name: tetrahydrofolylpolyglutamate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17] subset: gosubset_prok synonym: "folate polyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly(gamma-glutamate) synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamate synthase activity" EXACT [] synonym: "folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamyl synthetase activity" EXACT [EC:6.3.2.17] synonym: "formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "FPGS activity" EXACT [EC:6.3.2.17] synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate synthase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] xref: EC:6.3.2.17 xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN xref: Reactome:10396 "tetrahydrofolylpolyglutamate synthase activity" is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004327 name: formaldehyde dehydrogenase (glutathione) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1] comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries. subset: gosubset_prok is_obsolete: true consider: GO:0051903 consider: GO:0051907 [Term] id: GO:0004328 name: formamidase activity namespace: molecular_function alt_id: GO:0034566 def: "Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+)." [EC:3.5.1.49, RHEA:21951] subset: gosubset_prok synonym: "formamide amidohydrolase activity" EXACT [EC:3.5.1.49] synonym: "formamide hydrolase activity" EXACT [] xref: EC:3.5.1.49 xref: KEGG:R00524 xref: MetaCyc:FORMAMIDASE-RXN xref: RHEA:21951 xref: UM-BBD_reactionID:r0873 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004329 name: formate-tetrahydrofolate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3] subset: gosubset_prok synonym: "10-formyl-THF synthetase activity" EXACT [GOC:vw] synonym: "10-formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "formate:tetrahydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.3] synonym: "formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolate formylase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolic formylase activity" EXACT [EC:6.3.4.3] xref: EC:6.3.4.3 xref: MetaCyc:FORMATETHFLIG-RXN xref: Reactome:10407 "formate-tetrahydrofolate ligase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004331 name: fructose-2,6-bisphosphate 2-phosphatase activity namespace: molecular_function alt_id: GO:0004330 def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate." [EC:3.1.3.46] subset: gosubset_prok synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "fructose-2,6-bisphosphatase activity" EXACT [EC:3.1.3.46] xref: EC:3.1.3.46 xref: MetaCyc:3.1.3.46-RXN xref: Reactome:10434 "fructose-2,6-bisphosphate 2-phosphatase activity" is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0004332 name: fructose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13] subset: gosubset_prok synonym: "1,6-diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "aldolase activity" BROAD [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-monophosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "ketose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "phosphofructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "SMALDO" RELATED [EC:4.1.2.13] synonym: "zymohexase activity" EXACT [EC:4.1.2.13] xref: EC:4.1.2.13 xref: MetaCyc:F16ALDOLASE-RXN xref: Reactome:10435 "fructose-bisphosphate aldolase activity" is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004333 name: fumarate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate = fumarate + H(2)O." [EC:4.2.1.2, RHEA:12463] subset: gosubset_prok synonym: "(S)-malate hydro-lyase (fumarate-forming)" EXACT [EC:4.2.1.2] synonym: "(S)-malate hydro-lyase activity" EXACT [EC:4.2.1.2] synonym: "fumarase activity" EXACT [EC:4.2.1.2] synonym: "L-malate hydro-lyase activity" EXACT [EC:4.2.1.2] xref: EC:4.2.1.2 xref: KEGG:R01082 xref: MetaCyc:FUMHYDR-RXN xref: Reactome:10436 "fumarate hydratase activity" xref: RHEA:12463 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004334 name: fumarylacetoacetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." [EC:3.7.1.2, RHEA:10247] subset: gosubset_prok synonym: "4-fumarylacetoacetate fumarylhydrolase activity" EXACT [EC:3.7.1.2] synonym: "beta-diketonase activity" EXACT [EC:3.7.1.2] synonym: "fumarylacetoacetate hydrolase activity" EXACT [EC:3.7.1.2] xref: EC:3.7.1.2 xref: KEGG:R01364 xref: MetaCyc:FUMARYLACETOACETASE-RXN xref: Reactome:10438 "fumarylacetoacetase activity" xref: RHEA:10247 xref: UM-BBD_reactionID:r0107 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0004335 name: galactokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13556] subset: gosubset_prok synonym: "ATP:D-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "ATP:D-galactose-1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "galactokinase (phosphorylating)" EXACT [EC:2.7.1.6] xref: EC:2.7.1.6 xref: KEGG:R01092 xref: MetaCyc:GALACTOKIN-RXN xref: Reactome:10440 "galactokinase activity" xref: RHEA:13556 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004336 name: galactosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46] synonym: "beta-galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "beta-galactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "ceramide galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside-beta-D-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside.beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46] synonym: "galactosylceramide beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylceramide.beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylcerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galcerase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46] xref: EC:3.2.1.46 xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! ceramidase activity [Term] id: GO:0004337 name: geranyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.10, RHEA:19364] comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. subset: gosubset_prok synonym: "farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "farnesyl pyrophosphate synthetase activity" EXACT [] synonym: "farnesyl-diphosphate synthase activity" EXACT [] synonym: "farnesylpyrophosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "FPP synthetase activity" EXACT [EC:2.5.1.10] synonym: "geranyl transferase I" RELATED [EC:2.5.1.10] synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" EXACT [EC:2.5.1.10] synonym: "geranyltransferase activity" EXACT [EC:2.5.1.10] xref: EC:2.5.1.10 xref: KEGG:R02003 xref: MetaCyc:FPPSYN-RXN xref: Reactome:1265 "geranyltranstransferase activity" xref: RHEA:19364 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004338 name: glucan exo-1,3-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58] synonym: "1,3-beta-glucan glucohydrolase activity" BROAD [EC:3.2.1.58] synonym: "beta-1,3-glucan exo-hydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo (1->3)-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucosidase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-glucanohydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-glucanase activity" EXACT [EC:3.2.1.58] synonym: "glucan 1,3-beta-glucosidase activity" BROAD [GOC:mah] xref: EC:3.2.1.58 xref: MetaCyc:3.2.1.58-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0004339 name: glucan 1,4-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3] comment: Note that this term is not a child of 'alpha-glucosidase activity ; GO:0004558', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0004558 alpha-D-glucose is released. subset: gosubset_prok synonym: "1,4-alpha-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "amyloglucosidase activity" EXACT [EC:3.2.1.3] synonym: "exo-1,4-alpha-glucosidase activity" EXACT [EC:3.2.1.3] synonym: "gamma-1,4-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "gamma-amylase activity" EXACT [EC:3.2.1.3] synonym: "glucoamylase activity" EXACT [] synonym: "glucose amylase activity" EXACT [EC:3.2.1.3] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3] xref: EC:3.2.1.3 xref: MetaCyc:3.2.1.3-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004340 name: glucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate." [EC:2.7.1.2] subset: gosubset_prok synonym: "ATP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.2] synonym: "glucokinase (phosphorylating)" EXACT [EC:2.7.1.2] synonym: "glucose kinase activity" EXACT [EC:2.7.1.2] xref: EC:2.7.1.2 xref: MetaCyc:GLUCOKIN-RXN xref: Reactome:10457 "glucokinase activity" is_a: GO:0004396 ! hexokinase activity [Term] id: GO:0004341 name: gluconolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17] subset: gosubset_prok synonym: "aldonolactonase activity" EXACT [EC:3.1.1.17] synonym: "D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.17] synonym: "glucono-delta-lactonase activity" EXACT [EC:3.1.1.17] synonym: "gulonolactonase activity" EXACT [EC:3.1.1.17] synonym: "lactonase activity" BROAD [EC:3.1.1.17] xref: EC:3.1.1.17 xref: MetaCyc:GLUCONOLACT-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004342 name: glucosamine-6-phosphate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12175] comment: Note that this function was formerly EC:5.3.1.10. subset: gosubset_prok synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" EXACT [EC:3.5.99.6] synonym: "aminodeoxyglucosephosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "GlcN6P deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine phosphate deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine-6-phosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6] synonym: "phosphoglucosamine isomerase activity" EXACT [EC:3.5.99.6] synonym: "phosphoglucosaminisomerase activity" EXACT [EC:3.5.99.6] xref: EC:3.5.99.6 xref: KEGG:R00765 xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN xref: RHEA:12175 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004343 name: glucosamine 6-phosphate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)." [EC:2.3.1.4, RHEA:10295] subset: gosubset_prok synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "aminodeoxyglucosephosphate acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "D-glucosamine-6-P N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine 6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT [] synonym: "N-acetylglucosamine-6-phosphate synthase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine N-acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine transacetylase activity" EXACT [EC:2.3.1.4] xref: EC:2.3.1.4 xref: KEGG:R02058 xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN xref: Reactome:10461 "glucosamine 6-phosphate N-acetyltransferase activity" xref: RHEA:10295 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004344 name: glucose dehydrogenase activity namespace: molecular_function alt_id: GO:0008708 def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] synonym: "D-glucose:(acceptor) 1-oxidoreductase" EXACT [EC:1.1.99.10] synonym: "D-glucose:acceptor 1-oxidoreductase" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (acceptor) activity" EXACT [] synonym: "glucose dehydrogenase (Aspergillus) activity" NARROW [EC:1.1.99.10] synonym: "glucose dehydrogenase (decarboxylating)" EXACT [EC:1.1.99.10] xref: EC:1.1.99.10 xref: KEGG:R00305 xref: MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN xref: RHEA:24543 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0004345 name: glucose-6-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] subset: gosubset_prok synonym: "6-phosphoglucose dehydrogenas" RELATED [] synonym: "6-phosphoglucose dehydrogenase activity" EXACT [] synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.49] synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49] synonym: "G6PD activity" EXACT [EC:1.1.1.49] synonym: "G6PDH" EXACT [] synonym: "GDH" RELATED [] synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT [] synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT [] synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT [] synonym: "Zwischenferment" RELATED [] synonym: "zwischenferment" RELATED [EC:1.1.1.49] xref: EC:1.1.1.49 xref: MetaCyc:GLU6PDEHYDROG-RXN xref: Reactome:10468 "glucose-6-phosphate dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004346 name: glucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.9] subset: gosubset_prok synonym: "D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.9] synonym: "glucose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.9] xref: EC:3.1.3.9 xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN xref: Reactome:10470 "glucose-6-phosphatase activity" is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0004347 name: glucose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9] subset: gosubset_prok synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.9] synonym: "D-glucose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.9] synonym: "glucose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "hexose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9] synonym: "phosphoglucoisomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphoglucose isomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9] xref: EC:5.3.1.9 xref: MetaCyc:PGLUCISOM-RXN xref: Reactome:10472 "glucose-6-phosphate isomerase activity" is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004348 name: glucosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45] subset: gosubset_prok synonym: "acid beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-D-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucosylceramidase activity" EXACT [EC:3.2.1.45] synonym: "ceramide glucosidase activity" EXACT [EC:3.2.1.45] synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [EC:3.2.1.45] synonym: "GlcCer-beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosphingosine glucosylhydrolase activity" EXACT [EC:3.2.1.45] synonym: "glucosylcerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-D-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "psychosine hydrolase activity" EXACT [EC:3.2.1.45] xref: EC:3.2.1.45 xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! ceramidase activity [Term] id: GO:0004349 name: glutamate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+)." [EC:2.7.2.11, RHEA:14880] subset: gosubset_prok synonym: "ATP-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:gamma-L-glutamate phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamate kinase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamyl kinase activity" EXACT [EC:2.7.2.11] synonym: "glutamate kinase activity" EXACT [EC:2.7.2.11] xref: EC:2.7.2.11 xref: KEGG:R00239 xref: MetaCyc:GLUTKIN-RXN xref: RHEA:14880 is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004350 name: glutamate-5-semialdehyde dehydrogenase activity namespace: molecular_function alt_id: GO:0001513 def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH." [EC:1.2.1.41, RHEA:19544] subset: gosubset_prok synonym: "beta-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamyl phosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-phosphate reductase activity" EXACT [] synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamylphosphate reductase activity" EXACT [] synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.41] xref: EC:1.2.1.41 xref: KEGG:R03313 xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN xref: RHEA:19544 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004351 name: glutamate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15] subset: gosubset_prok synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15] synonym: "cysteic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "gamma-glutamate decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-aspartate-alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15] xref: EC:4.1.1.15 xref: MetaCyc:GLUTDECARBOX-RXN xref: Reactome:10480 "glutamate decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004352 name: glutamate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2] subset: gosubset_prok synonym: "glutamate dehydrogenase (NAD)" EXACT [EC:1.4.1.2] synonym: "glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2] synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD:glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "NADH-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] xref: EC:1.4.1.2 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0004353 name: glutamate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. subset: gosubset_prok synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3] synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.3] xref: EC:1.4.1.3 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN xref: MetaCyc:GLUTAMATE-SYN2-PWY xref: Reactome:10485 "glutamate dehydrogenase [NAD(P)+] activity" is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0004354 name: glutamate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4] subset: gosubset_prok synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.4.1.4] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4] synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.4] synonym: "L-glutamic acid dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)-glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] xref: EC:1.4.1.4 xref: MetaCyc:GLUTDEHYD-RXN xref: MetaCyc:GLUTSYNIII-PWY is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0004355 name: glutamate synthase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH." [EC:1.4.1.13, RHEA:15504] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. subset: gosubset_prok synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" EXACT [EC:1.4.1.13] synonym: "glutamate synthetase (NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine-ketoglutaric aminotransferase activity" EXACT [EC:1.4.1.13] synonym: "GOGAT activity" EXACT [EC:1.4.1.13] synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.13] synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" EXACT [EC:1.4.1.13] synonym: "NADPH-dependent glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-linked glutamate synthase" EXACT [EC:1.4.1.13] xref: EC:1.4.1.13 xref: KEGG:R00114 xref: MetaCyc:GLUGLNSYN-PWY xref: MetaCyc:GLUTAMATESYN-RXN xref: MetaCyc:GLUTSYN-PWY xref: RHEA:15504 is_a: GO:0045181 ! glutamate synthase activity, NADH or NADPH as acceptor [Term] id: GO:0004356 name: glutamate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172] subset: gosubset_prok synonym: "glutamine synthetase activity" EXACT [] synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2] synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2] synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2] xref: EC:6.3.1.2 xref: KEGG:R00253 xref: MetaCyc:GLUTAMINESYN-RXN xref: Reactome:10495 "glutamate-ammonia ligase activity" xref: RHEA:16172 is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0004357 name: glutamate-cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [EC:6.3.2.2, RHEA:13288] subset: gosubset_prok synonym: "gamma-glutamyl-L-cysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteinyl synthetase activity" EXACT [EC:6.3.2.2] synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.2] xref: EC:6.3.2.2 xref: KEGG:R00894 xref: MetaCyc:GLUTCYSLIG-RXN xref: Reactome:10497 "glutamate-cysteine ligase activity" xref: RHEA:13288 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004358 name: glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine." [EC:2.3.1.35, RHEA:15352] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35] synonym: "acetylornithine glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine transacetylase activity" EXACT [EC:2.3.1.35] xref: EC:2.3.1.35 xref: KEGG:R02282 xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN xref: RHEA:15352 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004359 name: glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2] subset: gosubset_prok synonym: "glutaminase I" RELATED [EC:3.5.1.2] synonym: "glutamine aminohydrolase activity" EXACT [EC:3.5.1.2] synonym: "L-glutaminase activity" EXACT [EC:3.5.1.2] synonym: "L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.2] xref: EC:3.5.1.2 xref: MetaCyc:GLUTAMIN-RXN xref: Reactome:10219 "glutaminase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004360 name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [EC:2.6.1.16, RHEA:13240] subset: gosubset_prok synonym: "D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "GlcN6P synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine 6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" EXACT [EC:2.6.1.16] synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT [] synonym: "glucosamine-6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16] synonym: "hexosephosphate aminotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" EXACT [EC:2.6.1.16] xref: EC:2.6.1.16 xref: KEGG:R00768 xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN xref: Reactome:10505 "glutamine-fructose-6-phosphate transaminase (isomerizing) activity" xref: RHEA:13240 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004361 name: glutaryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.99.7] subset: gosubset_prok synonym: "glutaryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.7] synonym: "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] synonym: "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] xref: EC:1.3.99.7 xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN xref: Reactome:10507 "glutaryl-CoA dehydrogenase activity" xref: UM-BBD_reactionID:r0198 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004362 name: glutathione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this function was formerly EC:1.6.4.2. subset: gosubset_prok synonym: "glutathione reductase (NADPH) activity" EXACT [] synonym: "glutathione reductase activity" EXACT [] synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7] synonym: "glutathione-disulphide reductase activity" EXACT [] synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "GSH reductase activity" EXACT [EC:1.8.1.7] synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "oxidized glutathione reduction" RELATED [] xref: EC:1.8.1.7 xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN xref: Reactome:10508 "glutathione-disulfide reductase activity" is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0004363 name: glutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13560] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" EXACT [EC:6.3.2.3] synonym: "glutathione synthetase activity" EXACT [EC:6.3.2.3] synonym: "GSH synthetase activity" EXACT [EC:6.3.2.3] xref: EC:6.3.2.3 xref: KEGG:R00497 xref: MetaCyc:GLUTATHIONE-SYN-RXN xref: Reactome:10524 "glutathione synthase activity" xref: RHEA:13560 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004364 name: glutathione transferase activity namespace: molecular_function def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] subset: gosubset_prok synonym: "glutathione conjugation reaction" EXACT [] synonym: "glutathione S-alkyl transferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-alkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aralkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aryltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-transferase activity" EXACT [EC:2.5.1.18] synonym: "RX:glutathione R-transferase activity" EXACT [EC:2.5.1.18] synonym: "S-(hydroxyalkyl)glutathione lyase activity" EXACT [EC:2.5.1.18] xref: EC:2.5.1.18 xref: MetaCyc:GSHTRAN-RXN xref: Reactome:10527 "glutathione transferase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004365 name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12] subset: gosubset_prok synonym: "3-phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.12] synonym: "dehydrogenase, glyceraldehyde phosphate" EXACT [EC:1.2.1.12] synonym: "GAPDH activity" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde-3-P-dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12] xref: EC:1.2.1.12 xref: MetaCyc:GAPOXNPHOSPHN-RXN xref: Reactome:10530 "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity" is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: GO:0004366 name: glycerol-3-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15] subset: gosubset_prok synonym: "3-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "alpha-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] xref: EC:2.3.1.15 xref: MetaCyc:RXN-1381 xref: Reactome:10531 "glycerol-3-phosphate O-acyltransferase activity" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004367 name: glycerol-3-phosphate dehydrogenase [NAD+] activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8] subset: gosubset_prok synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol 1-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] synonym: "glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "hydroglycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-alpha-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-alpha-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NADH-dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.8] xref: EC:1.1.1.8 xref: MetaCyc:1.1.1.8-RXN xref: Reactome:10533 "glycerol-3-phosphate dehydrogenase [NAD+] activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004368 name: glycerol-3-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3] comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. subset: gosubset_prok synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.5.3] synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.5.3] synonym: "glycerol-3-phosphate CoQ reductase" EXACT [EC:1.1.5.3] synonym: "glycerophosphate dehydrogenase activity" EXACT [EC:1.1.5.3] synonym: "L-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.5.3] synonym: "sn-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.5.3] synonym: "sn-glycerol-3-phosphate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.1.5.3] xref: EC:1.1.5.3 xref: MetaCyc:RXN-9927 xref: MetaCyc:RXN0-5260 xref: Reactome:10535 "glycerol-3-phosphate dehydrogenase activity" is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0004369 name: glycerol-3-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2)." [EC:1.1.3.21, RHEA:18372] subset: gosubset_prok synonym: "alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol-1-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerol-3-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.21] xref: EC:1.1.3.21 xref: KEGG:R00846 xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN xref: RHEA:18372 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0004370 name: glycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647] subset: gosubset_prok synonym: "ATP:glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "ATP:glycerol-3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "GK" RELATED [EC:2.7.1.30] synonym: "glyceric kinase activity" EXACT [EC:2.7.1.30] synonym: "glycerokinase activity" EXACT [EC:2.7.1.30] synonym: "glycerol kinase (phosphorylating)" EXACT [EC:2.7.1.30] xref: EC:2.7.1.30 xref: KEGG:R00847 xref: MetaCyc:GLYCEROL-KIN-RXN xref: Reactome:10545 "glycerol kinase activity" xref: RHEA:21647 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004371 name: glycerone kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+)." [EC:2.7.1.29, RHEA:15776] subset: gosubset_prok synonym: "acetol kinase (phosphorylating)" EXACT [EC:2.7.1.29] synonym: "acetol kinase activity" EXACT [EC:2.7.1.29] synonym: "ATP:glycerone phosphotransferase activity" EXACT [EC:2.7.1.29] synonym: "dihydroxyacetone kinase activity" EXACT [EC:2.7.1.29] xref: EC:2.7.1.29 xref: KEGG:R01011 xref: MetaCyc:GLYCERONE-KINASE-RXN xref: RHEA:15776 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004372 name: glycine hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "allothreonine aldolase activity" EXACT [EC:2.1.2.1] synonym: "L-serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine aldolase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethylase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine transhydroxymethylase activity" EXACT [EC:2.1.2.1] xref: EC:2.1.2.1 xref: MetaCyc:GLYOHMETRANS-RXN xref: Reactome:1060 "glycine hydroxymethyltransferase activity" is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004373 name: glycogen (starch) synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11] subset: gosubset_prok synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen transglucosylase activity" EXACT [EC:2.4.1.11] synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] xref: EC:2.4.1.11 xref: MetaCyc:2.4.1.11-RXN xref: Reactome:10552 "glycogen (starch) synthase activity" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0004374 name: glycine cleavage system namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [EC:1.4.4.2, EC:2.1.2.10] comment: This term was made obsolete because it represents a process rather than a function. synonym: "glycine synthase" BROAD [] is_obsolete: true replaced_by: GO:0019464 [Term] id: GO:0004375 name: glycine dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] subset: gosubset_prok synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2] synonym: "glycine decarboxylase activity" EXACT [EC:1.4.4.2] synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2] synonym: "glycine-cleavage complex P-protein activity" EXACT [EC:1.4.4.2] synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" EXACT [EC:1.4.4.2] synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" EXACT [EC:1.4.4.2] synonym: "P-protein" NARROW [EC:1.4.4.2] synonym: "protein P1" NARROW [EC:1.4.4.2] xref: EC:1.4.4.2 xref: MetaCyc:GCVP-RXN is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor [Term] id: GO:0004376 name: glycolipid mannosyltransferase activity namespace: molecular_function alt_id: GO:0004580 def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai] synonym: "glycolipid mannosyl transferase activity" EXACT [] xref: EC:2.4.1.- xref: Reactome:10559 "glycolipid mannosyltransferase activity" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004377 name: glycolipid 2-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose linkage." [EC:2.4.1.131] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] xref: EC:2.4.1.131 xref: MetaCyc:2.4.1.131-RXN is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0004378 name: glycolipid 3-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,3-D-mannosyl-D-mannose linkage." [EC:2.4.1.132] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132] synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "mannosyltransferase II activity" EXACT [EC:2.4.1.132] xref: EC:2.4.1.132 xref: MetaCyc:2.4.1.132-RXN is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0004379 name: glycylpeptide N-tetradecanoyltransferase activity namespace: molecular_function alt_id: GO:0019106 def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97] synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" EXACT [EC:2.3.1.97] synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97] synonym: "N-myristoyltransferase activity" EXACT [] synonym: "peptide N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "peptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] xref: EC:2.3.1.97 xref: MetaCyc:2.3.1.97-RXN is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0019107 ! myristoyltransferase activity [Term] id: GO:0004380 name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40] synonym: "A transferase activity" RELATED [EC:2.4.1.40] synonym: "A-transferase activity" EXACT [EC:2.4.1.40] synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance alpha-acetyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40] synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" EXACT [EC:2.4.1.40] synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40] synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] xref: EC:2.4.1.40 xref: MetaCyc:2.4.1.40-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0004381 name: fucosylgalactoside 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37] synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "B transferase activity" RELATED [EC:2.4.1.37] synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT [] synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37] synonym: "histo-blood substance B-dependent galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] xref: EC:2.4.1.37 xref: MetaCyc:2.4.1.37-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0004382 name: guanosine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286] synonym: "GDP phosphohydrolase activity" EXACT [EC:3.6.1.42] synonym: "GDPase activity" EXACT [EC:3.6.1.42] synonym: "guanosine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "guanosine diphosphatase activity" EXACT [] xref: EC:3.6.1.42 xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0004383 name: guanylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] subset: gosubset_prok synonym: "GTP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.2] synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" EXACT [EC:4.6.1.2] synonym: "guanyl cyclase activity" EXACT [EC:4.6.1.2] synonym: "guanylyl cyclase activity" EXACT [] synonym: "receptor guanylate cyclase activity" NARROW [] xref: EC:4.6.1.2 xref: MetaCyc:GUANYLCYC-RXN xref: Reactome:4317 "guanylate cyclase activity" is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004384 name: membrane-associated guanylate kinase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8] comment: This term was made obsolete because it represents a gene product and not a function. synonym: "MAGUK" EXACT [] is_obsolete: true consider: GO:0004385 consider: GO:0005102 consider: GO:0007155 consider: GO:0016021 consider: GO:0050839 [Term] id: GO:0004385 name: guanylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] subset: gosubset_prok synonym: "5'-GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "ATP:(d)GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "ATP:GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8] synonym: "GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "guanosine monophosphate kinase activity" EXACT [EC:2.7.4.8] synonym: "membrane-associated guanylate kinase" NARROW [] xref: EC:2.7.4.8 xref: MetaCyc:GUANYL-KIN-RXN xref: Reactome:10583 "guanylate kinase activity" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004386 name: helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that most helicases catalyze processive duplex unwinding. subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Reactome:7001 "helicase activity" is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0004392 name: heme oxygenase (decyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3] synonym: "haem oxidase activity" EXACT [EC:1.14.99.3] synonym: "haem oxygenase (decyclizing) activity" EXACT [] synonym: "haem oxygenase activity" EXACT [EC:1.14.99.3] synonym: "heme oxidase activity" EXACT [EC:1.14.99.3] synonym: "heme oxygenase activity" EXACT [EC:1.14.99.3] synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" EXACT [EC:1.14.99.3] synonym: "ORP33 proteins" RELATED [EC:1.14.99.3] xref: EC:1.14.99.3 xref: MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN xref: Reactome:10594 "heme oxygenase (decyclizing) activity" is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004394 name: heparan sulfate 2-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262] synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT [] synonym: "heparin 2-sulfotransferase activity" RELATED [] synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED [] xref: EC:2.8.2.- is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0004395 name: hexaprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] synonym: "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB-Mt activity" EXACT [EC:2.1.1.114] synonym: "dihydroxyhexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity" EXACT [EC:2.1.1.114] xref: EC:2.1.1.114 xref: MetaCyc:2.1.1.114-RXN is_a: GO:0010420 ! polyprenyldihydroxybenzoate methyltransferase activity [Term] id: GO:0004396 name: hexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1] subset: gosubset_prok synonym: "ATP-dependent hexokinase activity" EXACT [EC:2.7.1.1] synonym: "ATP:D-hexose 6-phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "glucose ATP phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "hexokinase (phosphorylating)" EXACT [EC:2.7.1.1] synonym: "hexokinase D" RELATED [EC:2.7.1.1] synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV" RELATED [EC:2.7.1.1] synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV glucokinase activity" EXACT [EC:2.7.1.1] xref: EC:2.7.1.1 xref: MetaCyc:HEXOKINASE-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004397 name: histidine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3] subset: gosubset_prok synonym: "histidase activity" RELATED [GOC:hjd] synonym: "histidinase activity" RELATED [GOC:hjd] synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd] synonym: "L-histidine ammonia-lyase (urocanate-forming)" EXACT [EC:4.3.1.3] synonym: "L-histidine ammonia-lyase activity" EXACT [EC:4.3.1.3] xref: EC:4.3.1.3 xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN xref: Reactome:10604 "histidine ammonia-lyase activity" is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0004398 name: histidine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22] subset: gosubset_prok synonym: "L-histidine carboxy-lyase (histamine-forming)" EXACT [EC:4.1.1.22] synonym: "L-histidine carboxy-lyase activity" EXACT [EC:4.1.1.22] synonym: "L-histidine decarboxylase activity" EXACT [EC:4.1.1.22] xref: EC:4.1.1.22 xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004399 name: histidinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [EC:1.1.1.23] subset: gosubset_prok xref: EC:1.1.1.23 xref: MetaCyc:HISTALDEHYD-RXN xref: MetaCyc:HISTOLDEHYD-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004400 name: histidinol-phosphate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9] subset: gosubset_prok synonym: "glutamic-imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidine:imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "histidinol-phosphate aminotransferase activity" EXACT [] synonym: "IAP transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazole acetol-phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.9] xref: EC:2.6.1.9 xref: MetaCyc:HISTAMINOTRANS-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004401 name: histidinol-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate." [EC:3.1.3.15, RHEA:14468] subset: gosubset_prok synonym: "histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "HPpase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.15] xref: EC:3.1.3.15 xref: KEGG:R03013 xref: MetaCyc:HISTIDPHOS-RXN xref: RHEA:14468 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004402 name: histone acetyltransferase activity namespace: molecular_function alt_id: GO:0004403 alt_id: GO:0004404 alt_id: GO:0004405 alt_id: GO:0004406 alt_id: GO:0043166 alt_id: GO:0046971 def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant. synonym: "acetyl-CoA:histone acetyltransferase activity" EXACT [EC:2.3.1.48] synonym: "H2A/H2B histone acetyltransferase activity" NARROW [] synonym: "H3/H4 histone acetyltransferase activity" NARROW [] synonym: "H4/H2 histone acetyltransferase activity" NARROW [] synonym: "H4/H2A acetyltransferase activity" NARROW [] synonym: "histone acetokinase activity" EXACT [EC:2.3.1.48] synonym: "histone acetylase activity" EXACT [] synonym: "histone lysine acetyltransferase activity" EXACT [] synonym: "histone transacetylase activity" EXACT [EC:2.3.1.48] synonym: "nucleosome-histone acetyltransferase activity" RELATED [EC:2.3.1.48] xref: EC:2.3.1.48 xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN is_a: GO:0004468 ! lysine N-acetyltransferase activity [Term] id: GO:0004407 name: histone deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.-, PMID:9893272] xref: EC:3.5.1.- xref: MetaCyc:3.5.1.98-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0033558 ! protein deacetylase activity [Term] id: GO:0004408 name: holocytochrome-c synthase activity namespace: molecular_function def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17] subset: gosubset_prok synonym: "cytochrome c heme-lyase activity" EXACT [EC:4.4.1.17] synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17] synonym: "holocytochrome c synthetase activity" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17] xref: EC:4.4.1.17 xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004409 name: homoaconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O." [EC:4.2.1.36, RHEA:15488] subset: gosubset_prok synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36] synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.36] synonym: "cis-homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "HACN activity" EXACT [EC:4.2.1.36] synonym: "homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "Lys4" RELATED [EC:4.2.1.36] synonym: "LysF" RELATED [EC:4.2.1.36] xref: EC:4.2.1.36 xref: KEGG:R04371 xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN xref: RHEA:15488 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004410 name: homocitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate." [EC:2.3.3.14, RHEA:12932] comment: Note that this function was formerly EC:4.1.3.21. subset: gosubset_prok synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.14] synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" EXACT [EC:2.3.3.14] synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" EXACT [EC:2.3.3.14] synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" EXACT [EC:2.3.3.14] synonym: "homocitrate synthetase activity" EXACT [EC:2.3.3.14] xref: EC:2.3.3.14 xref: KEGG:R00271 xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN xref: RHEA:12932 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004411 name: homogentisate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+)." [EC:1.13.11.5, RHEA:15452] subset: gosubset_prok synonym: "homogentisate dioxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisicase activity" EXACT [EC:1.13.11.5] xref: EC:1.13.11.5 xref: KEGG:R02519 xref: MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN xref: Reactome:11355 "homogentisate 1,2-dioxygenase activity" xref: RHEA:15452 xref: UM-BBD_reactionID:r0105 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004412 name: homoserine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3] subset: gosubset_prok xref: EC:1.1.1.3 xref: MetaCyc:HOMOSERDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004413 name: homoserine kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+)." [EC:2.7.1.39, RHEA:13988] subset: gosubset_prok synonym: "ATP:L-homoserine O-phosphotransferase activity" EXACT [EC:2.7.1.39] synonym: "homoserine kinase (phosphorylating)" EXACT [EC:2.7.1.39] synonym: "HSK" RELATED [EC:2.7.1.39] xref: EC:2.7.1.39 xref: KEGG:R01771 xref: MetaCyc:HOMOSERKIN-RXN xref: RHEA:13988 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004414 name: homoserine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA." [EC:2.3.1.31, RHEA:13704] subset: gosubset_prok synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine O-trans-acetylase activity" EXACT [EC:2.3.1.31] synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31] synonym: "homoserine-O-transacetylase activity" EXACT [EC:2.3.1.31] synonym: "L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] xref: EC:2.3.1.31 xref: KEGG:R01776 xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN xref: RHEA:13704 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004415 name: hyalurononglucosaminidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35] subset: gosubset_prok synonym: "chondroitinase activity" BROAD [EC:3.2.1.35] synonym: "chondroitinase I activity" EXACT [EC:3.2.1.35] synonym: "hyaluronate 4-glycanohydrolase activity" EXACT [EC:3.2.1.35] synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35] synonym: "hyaluronoglucosaminidase activity" EXACT [] synonym: "hyaluronoglucosidase activity" EXACT [EC:3.2.1.35] xref: EC:3.2.1.35 xref: MetaCyc:3.2.1.35-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004416 name: hydroxyacylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6] subset: gosubset_prok synonym: "acetoacetylglutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "glyoxalase II activity" EXACT [EC:3.1.2.6] synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "S-2-hydroxylacylglutathione hydrolase activity" EXACT [EC:3.1.2.6] xref: EC:3.1.2.6 xref: MetaCyc:GLYOXII-RXN is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0004417 name: hydroxyethylthiazole kinase activity namespace: molecular_function def: "Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+)." [EC:2.7.1.50, RHEA:24215] subset: gosubset_prok synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" EXACT [EC:2.7.1.50] synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" EXACT [EC:2.7.1.50] synonym: "hydroxyethylthiazole kinase (phosphorylating)" EXACT [EC:2.7.1.50] xref: EC:2.7.1.50 xref: KEGG:R04448 xref: MetaCyc:THIAZOLSYN3-RXN xref: RHEA:24215 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004418 name: hydroxymethylbilane synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [EC:2.5.1.61, RHEA:13188] comment: Note that this function was formerly EC:4.3.1.8. subset: gosubset_prok synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT [EC:2.5.1.61] synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "HMB-synthase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen ammonia-lyase (polymerizing)" EXACT [EC:2.5.1.61] synonym: "porphobilinogen deaminase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "pre-uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen synthetase activity" EXACT [EC:2.5.1.61] xref: EC:2.5.1.61 xref: KEGG:R00084 xref: MetaCyc:OHMETHYLBILANESYN-RXN xref: Reactome:11374 "hydroxymethylbilane synthase activity" xref: RHEA:13188 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004419 name: hydroxymethylglutaryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24407] subset: gosubset_prok synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.4] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "HMG-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4] xref: EC:4.1.3.4 xref: KEGG:R01360 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN xref: Reactome:74178 "hydroxymethylglutaryl-CoA lyase activity" xref: RHEA:24407 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004420 name: hydroxymethylglutaryl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [EC:1.1.1.34, RHEA:15992] subset: gosubset_prok synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34] synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34] xref: EC:1.1.1.34 xref: KEGG:R02082 xref: MetaCyc:1.1.1.34-RXN xref: Reactome:11408 "hydroxymethylglutaryl-CoA reductase (NADPH) activity" xref: RHEA:15992 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004421 name: hydroxymethylglutaryl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [EC:2.3.3.10, RHEA:10191] comment: Note that this function was formerly EC:4.1.3.5. subset: gosubset_prok synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.10] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "acetoacetyl coenzyme A transacetase activity" EXACT [EC:2.3.3.10] synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.10] synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "HMG-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" EXACT [EC:2.3.3.10] xref: EC:2.3.3.10 xref: KEGG:R01978 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN xref: Reactome:74169 "hydroxymethylglutaryl-CoA synthase activity" xref: RHEA:10191 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004422 name: hypoxanthine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] subset: gosubset_prok synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "HGPRTase activity" EXACT [EC:2.4.2.8] synonym: "HPRT" RELATED [EC:2.4.2.8] synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "IMP diphosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP-GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "inosinate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic acid pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8] xref: EC:2.4.2.8 xref: KEGG:R01132 xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN xref: Reactome:11410 "hypoxanthine phosphoribosyltransferase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004423 name: iduronate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13] subset: gosubset_prok synonym: "2-sulfo-L-iduronate 2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13] synonym: "iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulphatase activity" EXACT [] synonym: "iduronide-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "idurono-2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate 2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" EXACT [EC:3.1.6.13] synonym: "L-idurono sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronosulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfo-L-iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfoiduronate sulfohydrolase activity" EXACT [EC:3.1.6.13] xref: EC:3.1.6.13 xref: MetaCyc:3.1.6.13-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004424 name: imidazoleglycerol-phosphate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O." [EC:4.2.1.19, RHEA:11043] subset: gosubset_prok synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19] synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" EXACT [EC:4.2.1.19] synonym: "IGP dehydratase activity" EXACT [EC:4.2.1.19] synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT [] xref: EC:4.2.1.19 xref: KEGG:R03457 xref: MetaCyc:IMIDPHOSDEHYD-RXN xref: RHEA:11043 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004425 name: indole-3-glycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48] subset: gosubset_prok synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" EXACT [EC:4.1.1.48] synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48] synonym: "indole-3-glycerophosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthetase activity" EXACT [EC:4.1.1.48] xref: EC:4.1.1.48 xref: MetaCyc:IGPSYN-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004427 name: inorganic diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579] subset: gosubset_prok synonym: "diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] synonym: "inorganic pyrophosphatase activity" EXACT [EC:3.6.1.1] synonym: "pyrophosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] xref: EC:3.6.1.1 xref: KEGG:R00004 xref: MetaCyc:INORGPYROPHOSPHAT-RXN xref: Reactome:11425 "inorganic diphosphatase activity" xref: RHEA:24579 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004428 name: inositol or phosphatidylinositol kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] subset: gosubset_prok synonym: "inositol/phosphatidylinositol kinase activity" EXACT [] is_a: GO:0016301 ! kinase activity [Term] id: GO:0004430 name: 1-phosphatidylinositol 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19880] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.67] synonym: "phosphatidylinositol 4-kinase activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67] synonym: "PI 4-kinase activity" EXACT [EC:2.7.1.67] synonym: "PI kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4-kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4K" BROAD [EC:2.7.1.67] synonym: "PI4K-alpha activity" BROAD [EC:2.7.1.67] synonym: "PtdIns-4-kinase activity" BROAD [EC:2.7.1.67] synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67] xref: EC:2.7.1.67 xref: KEGG:R03361 xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN xref: RHEA:19880 is_a: GO:0001727 ! lipid kinase activity is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004432 name: 1-phosphatidylinositol-4-phosphate kinase, class IA namespace: molecular_function def: "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events." [PMID:11050418] comment: This term was made obsolete because it is not a valid molecular function. is_obsolete: true consider: GO:0016308 [Term] id: GO:0004433 name: 1-phosphatidylinositol-4-phosphate kinase, class IB namespace: molecular_function def: "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins." [PMID:11050418] comment: This term was made obsolete because it is not a valid molecular function. is_obsolete: true consider: GO:0016308 [Term] id: GO:0004435 name: phosphatidylinositol phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] subset: gosubset_prok synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11] synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED [] synonym: "phosphoinositidase C activity" EXACT [EC:3.1.4.11] synonym: "phosphoinositide phospholipase C activity" EXACT [EC:3.1.4.11] synonym: "PI-PLC activity" EXACT [EC:3.1.4.11] synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11] xref: EC:3.1.4.11 xref: KEGG:R03435 xref: MetaCyc:3.1.4.11-RXN xref: Reactome:11456 "phosphatidylinositol phospholipase C activity" xref: RHEA:23915 is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0004436 name: phosphatidylinositol diacylglycerol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13] comment: Note that this function was formerly EC:3.1.4.10. subset: gosubset_prok synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13] xref: EC:4.6.1.13 xref: MetaCyc:3.1.4.10-RXN is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004437 name: inositol or phosphatidylinositol phosphatase activity namespace: molecular_function def: "Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] subset: gosubset_prok synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT [] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004438 name: phosphatidylinositol-3-phosphatase activity namespace: molecular_function alt_id: GO:0016315 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64] comment: Note that this function includes EC:3.1.3.65. synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "inositol 1,3-bisphosphate phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,4,-bisphosphate 3-phosphatase activity" EXACT [] synonym: "inositol-polyphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] xref: EC:3.1.3.64 xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity is_a: GO:0042577 ! lipid phosphatase activity [Term] id: GO:0004439 name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity namespace: molecular_function alt_id: GO:0001668 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767] synonym: "inositol 1,4,5-triphosphate 5-phosphomonoesterase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36] synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36] synonym: "PtdIns(4,5)P(2) phosphatase activity" EXACT [EC:3.1.3.36] synonym: "PtdIns(4,5)P2 phosphatase activity" EXACT [EC:3.1.3.36] synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36] synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36] xref: EC:3.1.3.36 xref: KEGG:R04404 xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN xref: RHEA:22767 is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity [Term] id: GO:0004441 name: inositol-1,4-bisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb] synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.57] synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57] synonym: "inositol-polyphosphate 1-phosphatase activity" EXACT [EC:3.1.3.57] xref: EC:3.1.3.57 xref: MetaCyc:3.1.3.57-RXN is_a: GO:0016312 ! inositol bisphosphate phosphatase activity [Term] id: GO:0004442 name: inositol-1,4,-bisphosphate 3-phosphatase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators] is_obsolete: true consider: GO:0004438 [Term] id: GO:0004443 name: inositol-1,4,-bisphosphate 4-phosphatase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators] is_obsolete: true consider: GO:0016316 [Term] id: GO:0004444 name: inositol-1,4,5-trisphosphate 1-phosphatase namespace: molecular_function def: "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb] comment: This term was made obsolete because the existence of this function has not been established. is_obsolete: true consider: GO:0046030 [Term] id: GO:0004445 name: inositol-polyphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56] comment: Note that this is a compound function and should be replaced by 'GO:0052659 : inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity' and 'GO:0052658 : inositol-1,4,5-trisphosphate 5-phosphatase activity'. synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.56] synonym: "5PTase activity" RELATED [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "inositol polyphosphate-5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inositol triphosphate 5-phosphomonoesterase activity" RELATED [] synonym: "inositol trisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.56] synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "Ins(1,4,5)P3 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] xref: EC:3.1.3.56 is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] id: GO:0004446 name: multiple inositol-polyphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62] synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.62] synonym: "inositol tetrakisphosphate phosphomonoesterase activity" EXACT [EC:3.1.3.62] synonym: "MIPP activity" EXACT [EC:3.1.3.62] xref: EC:3.1.3.62 xref: MetaCyc:RXN-7920 is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0004447 name: iodide peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O." [EC:1.11.1.8] synonym: "iodide peroxidase-tyrosine iodinase activity" EXACT [EC:1.11.1.8] synonym: "iodide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.8] synonym: "iodinase activity" RELATED [EC:1.11.1.8] synonym: "iodoperoxidase (heme type)" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodase activity" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "monoiodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8] synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8] synonym: "TPO activity" RELATED [EC:1.11.1.8] synonym: "tyrosine iodinase activity" EXACT [EC:1.11.1.8] xref: EC:1.11.1.8 xref: MetaCyc:IODIDE-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004448 name: isocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42] subset: gosubset_prok synonym: "beta-ketoglutaric-isocitric carboxylase activity" EXACT [EC:1.1.1.-] synonym: "IDH activity" EXACT [EC:1.1.1.-] synonym: "IDP activity" EXACT [EC:1.1.1.-] synonym: "IDP1" RELATED [EC:1.1.1.-] synonym: "IDP2" RELATED [EC:1.1.1.-] synonym: "IDP3" RELATED [EC:1.1.1.-] synonym: "isocitric acid dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "isocitric dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate carboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate decarboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalsuccinic decarboxylase activity" EXACT [EC:1.1.1.-] xref: EC:1.1.1.- xref: MetaCyc:ISOCITDEH-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004449 name: isocitrate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41] subset: gosubset_prok synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41] synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41] synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] xref: EC:1.1.1.41 xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN xref: Reactome:11496 "isocitrate dehydrogenase (NAD+) activity" is_a: GO:0004448 ! isocitrate dehydrogenase activity [Term] id: GO:0004450 name: isocitrate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42] subset: gosubset_prok synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] synonym: "isocitrate (NADP) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP-dependent) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.42] synonym: "NADP isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-ICDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-IDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] xref: EC:1.1.1.42 xref: MetaCyc:ISOCITDEH-RXN xref: Reactome:11499 "isocitrate dehydrogenase (NADP+) activity" is_a: GO:0004448 ! isocitrate dehydrogenase activity [Term] id: GO:0004451 name: isocitrate lyase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate = glyoxylate + succinate." [EC:4.1.3.1, RHEA:13248] subset: gosubset_prok synonym: "ICL activity" EXACT [EC:4.1.3.1] synonym: "isocitrase activity" EXACT [EC:4.1.3.1] synonym: "isocitratase activity" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase (succinate-forming)" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] synonym: "isocitritase activity" EXACT [EC:4.1.3.1] synonym: "threo-DS-isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] xref: EC:4.1.3.1 xref: KEGG:R00479 xref: MetaCyc:ISOCIT-CLEAV-RXN xref: RHEA:13248 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004452 name: isopentenyl-diphosphate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate." [EC:5.3.3.2, RHEA:23287] subset: gosubset_prok synonym: "IPP isomerase activity" EXACT [EC:5.3.3.2] synonym: "ipp isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT [] synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate delta-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate Delta-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] synonym: "methylbutenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] xref: EC:5.3.3.2 xref: KEGG:R01123 xref: MetaCyc:IPPISOM-RXN xref: Reactome:11501 "isopentenyl-diphosphate delta-isomerase activity" xref: RHEA:23287 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004453 name: juvenile-hormone esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59, EMBL:AF304352] synonym: "JH esterase activity" EXACT [EC:3.1.1.59] synonym: "JH-esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone analog esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone carboxyesterase activity" EXACT [EC:3.1.1.59] synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" EXACT [EC:3.1.1.59] xref: EC:3.1.1.59 xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004454 name: ketohexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3] subset: gosubset_prok synonym: "ATP:D-fructose 1-phosphotransferase activity" EXACT [EC:2.7.1.3] synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3] synonym: "ketohexokinase (phosphorylating)" EXACT [EC:2.7.1.3] xref: EC:2.7.1.3 xref: MetaCyc:KETOHEXOKINASE-RXN xref: Reactome:11506 "ketohexokinase activity" is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004455 name: ketol-acid reductoisomerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86] subset: gosubset_prok synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.86] synonym: "2-hydroxy-3-keto acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetolactate reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" EXACT [EC:1.1.1.86] synonym: "isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86] xref: EC:1.1.1.86 xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004456 name: phosphogluconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O." [EC:4.2.1.12, RHEA:17280] subset: gosubset_prok synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" EXACT [EC:4.2.1.12] synonym: "6-phospho-D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydrase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconic dehydrase activity" EXACT [EC:4.2.1.12] synonym: "gluconate 6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "gluconate-6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] xref: EC:4.2.1.12 xref: KEGG:R02036 xref: MetaCyc:PGLUCONDEHYDRAT-RXN xref: RHEA:17280 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004457 name: lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidation of lactate to produce pyruvate." [GOC:ai] subset: gosubset_prok is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0004458 name: D-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4] subset: gosubset_prok synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-(-)-lactic cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate (cytochrome) dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4] xref: EC:1.1.2.4 xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0004459 name: L-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27] subset: gosubset_prok synonym: "L-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.27] synonym: "L-lactic dehydrogenase activity" EXACT [EC:1.1.1.27] xref: EC:1.1.1.27 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN xref: Reactome:11515 "L-lactate dehydrogenase activity" is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004460 name: L-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.3] subset: gosubset_prok synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "cytochrome b2" RELATED [] synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3] synonym: "dehydrogenase, lactate (cytochrome)" EXACT [EC:1.1.2.3] synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3] synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c reductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "lactate dehydrogenase (cytochrome)" EXACT [EC:1.1.2.3] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3] synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3] xref: EC:1.1.2.3 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0004461 name: lactose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22] synonym: "lactose synthetase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] xref: EC:2.4.1.22 xref: MetaCyc:LACTOSE-SYNTHASE-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0004462 name: lactoylglutathione lyase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072] subset: gosubset_prok synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" EXACT [EC:4.4.1.5] synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" EXACT [EC:4.4.1.5] synonym: "aldoketomutase activity" EXACT [EC:4.4.1.5] synonym: "glyoxalase I activity" EXACT [EC:4.4.1.5] synonym: "glyoxylase I" RELATED [EC:4.4.1.5] synonym: "ketone-aldehyde mutase activity" EXACT [EC:4.4.1.5] synonym: "methylglyoxalase activity" EXACT [EC:4.4.1.5] xref: EC:4.4.1.5 xref: KEGG:R02530 xref: MetaCyc:GLYOXI-RXN xref: RHEA:19072 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004463 name: leukotriene-A4 hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22327] subset: gosubset_prok synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A(4) hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA-4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4H" RELATED [EC:3.3.2.6] xref: EC:3.3.2.6 xref: KEGG:R03057 xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN xref: Reactome:1463 "leukotriene-A4 hydrolase activity" xref: RHEA:22327 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0004464 name: leukotriene-C4 synthase activity namespace: molecular_function def: "Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)." [EC:4.4.1.20, RHEA:17620] comment: Note that this function was EC:2.5.1.37. synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" EXACT [EC:4.4.1.20] synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" EXACT [EC:4.4.1.20] synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C4 synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthetase activity" EXACT [EC:4.4.1.20] xref: EC:4.4.1.20 xref: KEGG:R03059 xref: MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN xref: Reactome:11538 "leukotriene-C4 synthase activity" xref: RHEA:17620 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004465 name: lipoprotein lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.34] synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34] synonym: "diacylglycerol hydrolase activity" EXACT [EC:3.1.1.34] synonym: "diacylglycerol lipase activity" EXACT [EC:3.1.1.34] synonym: "diglyceride lipase activity" EXACT [EC:3.1.1.34] synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34] synonym: "postheparin esterase activity" EXACT [EC:3.1.1.34] synonym: "postheparin lipase activity" EXACT [EC:3.1.1.34] synonym: "triacylglycero-protein acylhydrolase activity" EXACT [EC:3.1.1.34] xref: EC:3.1.1.34 xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN xref: Reactome:11541 "lipoprotein lipase activity" is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004466 name: long-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF." [EC:1.3.99.13] subset: gosubset_prok synonym: "long-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] synonym: "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] synonym: "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] synonym: "palmitoyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.13] synonym: "palmitoyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] xref: EC:1.3.99.13 xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004467 name: long-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18." [EC:6.2.1.3] subset: gosubset_prok synonym: "ACS3" NARROW [EC:6.2.1.3] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.3] synonym: "acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "FAA1" NARROW [EC:6.2.1.3] synonym: "fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3] synonym: "fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3] synonym: "LCFA synthetase activity" EXACT [EC:6.2.1.3] synonym: "lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3] synonym: "long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase activity" EXACT [] synonym: "long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain fatty acid activation" RELATED [] synonym: "long-chain fatty acid-CoA ligase activity" EXACT [] synonym: "long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain-fatty-acid-CoA ligase activity" EXACT [] synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT [] synonym: "oleoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA ligase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA synthase" NARROW [EC:6.2.1.3] synonym: "pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "stearoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "thiokinase" RELATED [EC:6.2.1.3] xref: EC:6.2.1.3 xref: MetaCyc:ACYLCOASYN-RXN xref: MetaCyc:PWY-5143 xref: Reactome:11544 "long-chain fatty acid-CoA ligase activity" xref: UM-BBD_enzymeID:e0025 is_a: GO:0015645 ! fatty acid ligase activity [Term] id: GO:0004468 name: lysine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32] subset: gosubset_prok synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "LAT activity" EXACT [EC:2.3.1.32] synonym: "lysine acetyltransferase activity" EXACT [] synonym: "lysine N(6)-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] xref: EC:2.3.1.32 xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004470 name: malic enzyme activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyruvic-malic carboxylase activity" EXACT [EC:1.1.1.39] is_a: GO:0016615 ! malate dehydrogenase activity [Term] id: GO:0004471 name: malate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate." [EC:1.1.1.39] subset: gosubset_prok synonym: "'malic' enzyme" RELATED [EC:1.1.1.39] synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.39] synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.39] synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.39] xref: EC:1.1.1.39 xref: MetaCyc:1.1.1.39-RXN is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004473 name: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate." [EC:1.1.1.40] subset: gosubset_prok synonym: "'malic' enzyme" RELATED [EC:1.1.1.40] synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.40] synonym: "L-malate:NADP oxidoreductase activity" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (decarboxylating, NADP)" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (NADP, decarboxylating)" EXACT [EC:1.1.1.40] synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40] synonym: "NADP-malic enzyme activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malate dehydrogenase activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40] xref: EC:1.1.1.40 xref: MetaCyc:MALIC-NADP-RXN is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004474 name: malate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18184] comment: Note that this function was formerly EC:4.1.3.2. subset: gosubset_prok synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetylase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylic transacetase activity" EXACT [EC:2.3.3.9] synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.9] synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9] synonym: "malate synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9] xref: EC:2.3.3.9 xref: KEGG:R00472 xref: MetaCyc:MALSYN-RXN xref: RHEA:18184 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004475 name: mannose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [EC:2.7.7.13, RHEA:15232] subset: gosubset_prok synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13] synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine diphosphomannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" EXACT [EC:2.7.7.13] synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13] xref: EC:2.7.7.13 xref: KEGG:R00885 xref: MetaCyc:2.7.7.13-RXN xref: Reactome:11563 "mannose-1-phosphate guanylyltransferase activity" xref: RHEA:15232 is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0004476 name: mannose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8] subset: gosubset_prok synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.8] synonym: "D-mannose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.8] synonym: "mannose phosphate isomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8] synonym: "phosphomannoisomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphomannose isomerase activity" EXACT [EC:5.3.1.8] xref: EC:5.3.1.8 xref: MetaCyc:MANNPISOM-RXN xref: Reactome:11564 "mannose-6-phosphate isomerase activity" is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004477 name: methenyltetrahydrofolate cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9] subset: gosubset_prok synonym: "5,10-methenyl-THF cyclohydrolase activity" EXACT [GOC:vw] synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" EXACT [EC:3.5.4.9] synonym: "citrovorum factor cyclodehydrase activity" EXACT [EC:3.5.4.9] synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" EXACT [EC:3.5.4.9] xref: EC:3.5.4.9 xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN xref: Reactome:11565 "methenyltetrahydrofolate cyclohydrolase activity" is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0004478 name: methionine adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] subset: gosubset_prok synonym: "adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "AdoMet synthetase activity" EXACT [EC:2.5.1.6] synonym: "ATP-methionine adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "ATP:L-methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6] synonym: "S-adenosyl-L-methionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] xref: EC:2.5.1.6 xref: MetaCyc:S-ADENMETSYN-RXN xref: Reactome:11567 "methionine adenosyltransferase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004479 name: methionyl-tRNA formyltransferase activity namespace: molecular_function alt_id: GO:0001718 alt_id: GO:0070128 def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "conversion of met-tRNAf to fmet-tRNA" RELATED [GO:curators] synonym: "conversion of mitochondrial met-tRNAf to fmet-tRNA" RELATED [GO:curators] synonym: "formylmethionyl-transfer ribonucleic synthetase activity" EXACT [EC:2.1.2.9] synonym: "methionyl ribonucleic formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer RNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA Met formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "mitochondrial N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] xref: EC:2.1.2.9 xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004481 name: methylene-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" EXACT [EC:2.1.1.16] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16] xref: EC:2.1.1.16 xref: MetaCyc:2.1.1.16-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004482 name: mRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56] synonym: "guanine-7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger RNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.56] xref: EC:2.1.1.56 xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN xref: Reactome:72079 "mRNA (guanine-N7-)-methyltransferase activity" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0004483 name: mRNA (nucleoside-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57] subset: gosubset_prok synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] xref: EC:2.1.1.57 xref: MetaCyc:2.1.1.57-RXN is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0004484 name: mRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50] synonym: "GTP--RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "GTP:mRNA guanylyltransferase activity" EXACT [] synonym: "messenger RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50] synonym: "protein lambda2" RELATED [EC:2.7.7.50] xref: EC:2.7.7.50 xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN xref: Reactome:80327 "mRNA guanylyltransferase activity" is_a: GO:0008192 ! RNA guanylyltransferase activity [Term] id: GO:0004485 name: methylcrotonoyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.4, RHEA:13592] subset: gosubset_prok synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] xref: EC:6.4.1.4 xref: KEGG:R04138 xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN xref: Reactome:11585 "methylcrotonoyl-CoA carboxylase activity" xref: RHEA:13592 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0004486 name: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.-, EC:1.5.1.15] subset: gosubset_prok synonym: "5,10-methylene-THF dehydrogenase activity" EXACT [GOC:vw] synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1.- xref: Reactome:11590 "methylenetetrahydrofolate dehydrogenase activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004487 name: methylenetetrahydrofolate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH." [EC:1.5.1.15, RHEA:22895] synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" EXACT [EC:1.5.1.15] xref: EC:1.5.1.15 xref: KEGG:R01218 xref: MetaCyc:1.5.1.15-RXN xref: RHEA:22895 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004488 name: methylenetetrahydrofolate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22815] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1.5 xref: KEGG:R01220 xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN xref: RHEA:22815 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004489 name: methylenetetrahydrofolate reductase (NADPH) activity namespace: molecular_function alt_id: GO:0008702 def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20] comment: Includes EC 1.7.99.5. subset: gosubset_prok synonym: "1.7.99.5" RELATED [] synonym: "5,10-CH(2)-H(4)folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-CH2-H4folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "MetF" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH2)" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "MTHFR activity" BROAD [EC:1.5.1.20] synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N5,10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] synonym: "N5,N10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] xref: EC:1.5.1.20 xref: MetaCyc:1.5.1.20-RXN xref: Reactome:11594 "methylenetetrahydrofolate reductase (NADPH) activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004490 name: methylglutaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O." [EC:4.2.1.18, RHEA:21539] subset: gosubset_prok synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" EXACT [EC:4.2.1.18] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.18] synonym: "3-methylglutaconyl CoA hydratase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.18] xref: EC:4.2.1.18 xref: KEGG:R02085 xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN xref: Reactome:11601 "methylglutaconyl-CoA hydratase activity" xref: RHEA:21539 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004491 name: methylmalonate-semialdehyde dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27] subset: gosubset_prok synonym: "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)" EXACT [EC:1.2.1.27] synonym: "MMSA dehydrogenase activity" EXACT [EC:1.2.1.27] synonym: "MSDH activity" EXACT [EC:1.2.1.27] xref: EC:1.2.1.27 xref: MetaCyc:1.2.1.27-RXN xref: Reactome:70889 "methylmalonate-semialdehyde dehydrogenase (acylating) activity" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004492 name: methylmalonyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2." [EC:4.1.1.41] subset: gosubset_prok synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" EXACT [EC:4.1.1.41] synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] synonym: "methylmalonyl-coenzyme A decarboxylase activity" EXACT [EC:4.1.1.41] xref: EC:4.1.1.41 xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004493 name: methylmalonyl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA." [EC:5.1.99.1, RHEA:20556] subset: gosubset_prok synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "DL-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] synonym: "dl-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl coenzyme A racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] xref: EC:5.1.99.1 xref: KEGG:R02765 xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN xref: Reactome:11610 "methylmalonyl-CoA epimerase activity" xref: RHEA:20556 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0004494 name: methylmalonyl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA." [EC:5.4.99.2, RHEA:22891] subset: gosubset_prok synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(S)-methylmalonyl-CoA mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" EXACT [EC:5.4.99.2] xref: EC:5.4.99.2 xref: KEGG:R00833 xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN xref: Reactome:11612 "methylmalonyl-CoA mutase activity" xref: RHEA:22891 xref: UM-BBD_reactionID:r0922 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0004495 name: mevaldate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33] xref: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004496 name: mevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17068] subset: gosubset_prok synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "ATP:mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate kinase (phosphorylating)" EXACT [EC:2.7.1.36] synonym: "mevalonate phosphokinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic acid kinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic kinase activity" EXACT [EC:2.7.1.36] synonym: "MVA kinase activity" EXACT [EC:2.7.1.36] xref: EC:2.7.1.36 xref: KEGG:R02245 xref: MetaCyc:MEVALONATE-KINASE-RXN xref: Reactome:11620 "mevalonate kinase activity" xref: RHEA:17068 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004497 name: monooxygenase activity namespace: molecular_function def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "hydroxylase activity" RELATED [GOC:mah, GOC:vk] xref: Reactome:9021 "monooxygenase activity" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004498 name: calcidiol 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+)." [EC:1.14.13.13, RHEA:20576] synonym: "1-hydroxylase-25-hydroxyvitamin D3" RELATED [EC:1.14.13.13] synonym: "25-hydroxy D3-1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-OHD-1 alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.13] synonym: "cytochrome P450 CYP27B" NARROW [] xref: EC:1.14.13.13 xref: KEGG:R03610 xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN xref: Reactome:11623 "calcidiol 1-monooxygenase activity" xref: RHEA:20576 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004499 name: flavin-containing monooxygenase activity namespace: molecular_function alt_id: GO:0047076 def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8] subset: gosubset_prok synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT [] synonym: "dimethylaniline N-oxidase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline oxidase activity" EXACT [EC:1.13.12.11] synonym: "DMA oxidase activity" EXACT [EC:1.13.12.11] synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "flavin mixed function oxidase activity" RELATED [EC:1.13.12.11] synonym: "flavin monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "FMO activity" RELATED [EC:1.13.12.11] synonym: "FMO-I" RELATED [EC:1.13.12.11] synonym: "FMO-II" RELATED [EC:1.13.12.11] synonym: "FMO1" RELATED [EC:1.13.12.11] synonym: "FMO2" RELATED [EC:1.13.12.11] synonym: "FMO3" RELATED [EC:1.13.12.11] synonym: "FMO4" RELATED [EC:1.13.12.11] synonym: "FMO5" RELATED [EC:1.13.12.11] synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT [] synonym: "mixed-function amine oxidase activity" RELATED [EC:1.13.12.11] synonym: "N,N-dimethylaniline monooxygenase activity" EXACT [EC:1.13.12.11] synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" EXACT [EC:1.13.12.11] synonym: "Ziegler's enzyme" RELATED [EC:1.13.12.11] xref: EC:1.14.13.8 xref: MetaCyc:1.14.13.8-RXN xref: Reactome:11625 "flavin-containing monooxygenase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004500 name: dopamine beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19120] subset: gosubset_prok synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" EXACT [EC:1.14.17.1] synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopa beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine b-hydroxylase activity" EXACT [] synonym: "dopamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopamine hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine-B-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] synonym: "oxygenase, dopamine beta-mono-" EXACT [EC:1.14.17.1] synonym: "phenylamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] xref: EC:1.14.17.1 xref: KEGG:R02535 xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN xref: Reactome:12238 "dopamine beta-monooxygenase activity" xref: RHEA:19120 is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004501 name: ecdysone 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O." [EC:1.14.99.22, RHEA:14024] synonym: "alpha-ecdysone C-20 hydroxylase activity" EXACT [EC:1.14.99.22] synonym: "ecdysone 20-hydroxylase activity" EXACT [] synonym: "ecdysone modification" BROAD [] synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.99.22] xref: EC:1.14.99.22 xref: KEGG:R02374 xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN xref: RHEA:14024 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004502 name: kynurenine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+)." [EC:1.14.13.9, RHEA:20548] subset: gosubset_prok synonym: "kynurenine 3-hydroxylase activity" EXACT [] synonym: "kynurenine hydroxylase activity" EXACT [EC:1.14.13.9] synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.9] synonym: "L-kynurenine-3-hydroxylase activity" EXACT [EC:1.14.13.9] xref: EC:1.14.13.9 xref: KEGG:R01960 xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN xref: Reactome:12242 "kynurenine 3-monooxygenase activity" xref: RHEA:20548 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004503 name: monophenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1] subset: gosubset_prok synonym: "catecholase" BROAD [EC:1.14.18.1] synonym: "chlorogenic acid oxidase activity" EXACT [EC:1.14.18.1] synonym: "chlorogenic oxidase activity" EXACT [EC:1.14.18.1] synonym: "cresolase activity" EXACT [EC:1.14.18.1] synonym: "dopa oxidase" BROAD [EC:1.14.18.1] synonym: "monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol monooxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxygenase" EXACT [PMID:2494997] synonym: "monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol,L-dopa:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenolase activity" EXACT [EC:1.14.18.1] synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol oxidase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol oxidoreductase" BROAD [EC:1.14.18.1] synonym: "o-diphenol:O2 oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.14.18.1] synonym: "phenol oxidase activity" EXACT [] synonym: "phenolase activity" BROAD [EC:1.14.18.1] synonym: "polyaromatic oxidase activity" EXACT [EC:1.14.18.1] synonym: "polyphenolase activity" EXACT [EC:1.14.18.1] synonym: "prophenol oxidase" RELATED [] synonym: "pyrocatechol oxidase" BROAD [EC:1.14.18.1] synonym: "tyrosinase activity" BROAD [EC:1.14.18.1] synonym: "tyrosine-dopa oxidase activity" EXACT [EC:1.14.18.1] xref: EC:1.14.18.1 xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004504 name: peptidylglycine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3] subset: gosubset_prok synonym: "PAM activity" EXACT [EC:1.14.17.3] synonym: "PAM-A" RELATED [EC:1.14.17.3] synonym: "PAM-B" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amide synthase activity" EXACT [EC:1.14.17.3] synonym: "peptide-alpha-amide synthetase activity" EXACT [EC:1.14.17.3] synonym: "peptidyl alpha-amidating enzyme activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine 2-hydroxylase activity" EXACT [] synonym: "peptidylglycine alpha-amidating monooxygenase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine alpha-hydroxylase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.17.3] synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3] xref: EC:1.14.17.3 xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004505 name: phenylalanine 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1] subset: gosubset_prok synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.1] synonym: "PAH activity" EXACT [EC:1.14.16.1] synonym: "phenylalaninase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine 4-hydroxylase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine hydroxylase activity" EXACT [] xref: EC:1.14.16.1 xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN xref: Reactome:12249 "phenylalanine 4-monooxygenase activity" is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004506 name: squalene monooxygenase activity namespace: molecular_function def: "Catalysis of the formation of a 2,3-epoxide in squalene." [EC:1.14.99.7] synonym: "squalene 2,3-oxidocyclase activity" EXACT [EC:1.14.99.7] synonym: "squalene epoxidase activity" EXACT [EC:1.14.99.7] synonym: "squalene hydroxylase activity" EXACT [] synonym: "squalene oxydocyclase activity" EXACT [EC:1.14.99.7] synonym: "squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.7] synonym: "squalene-2,3-epoxidase activity" EXACT [EC:1.14.99.7] synonym: "squalene-2,3-epoxide cyclase activity" EXACT [EC:1.14.99.7] xref: EC:1.14.99.7 xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN xref: Reactome:12251 "squalene monooxygenase activity" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004507 name: steroid 11-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4] synonym: "cytochrome P450 CYP11B1" NARROW [] synonym: "cytochrome P450 CYP11B2" NARROW [] synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4] synonym: "oxygenase, steroid 11beta -mono-" EXACT [EC:1.14.15.4] synonym: "steroid 11-beta-hydroxylase activity" EXACT [] synonym: "steroid 11-beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-monooxygenase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" EXACT [EC:1.14.15.4] xref: EC:1.14.15.4 xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN xref: Reactome:12257 "steroid 11-beta-monooxygenase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004508 name: steroid 17-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9] synonym: "17alpha-hydroxylase-C17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.99.9] synonym: "cytochrome P450 CYP17" NARROW [] synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.99.9] synonym: "cytochrome P45017alpha" RELATED [EC:1.14.99.9] synonym: "steroid 17-alpha-hydroxylase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alpha-hydroxylase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alpha-monooxygenase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alphahydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" EXACT [EC:1.14.99.9] xref: EC:1.14.99.9 xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN xref: Reactome:12260 "steroid 17-alpha-monooxygenase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004509 name: steroid 21-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O." [EC:1.14.99.10] synonym: "21-hydroxylase activity" EXACT [EC:1.14.99.10] synonym: "cytochrome P450 CYP21A1" NARROW [] synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.99.10] synonym: "steroid 21-hydroxylase activity" EXACT [] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" EXACT [EC:1.14.99.10] xref: EC:1.14.99.10 xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN xref: Reactome:12262 "steroid 21-monooxygenase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004510 name: tryptophan 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4] synonym: "indoleacetic acid-5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "L-tryptophan hydroxylase activity" EXACT [] synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.16.4] synonym: "tryptophan 5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "tryptophan hydroxylase activity" EXACT [EC:1.14.16.4] xref: EC:1.14.16.4 xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN xref: Reactome:12281 "tryptophan 5-monooxygenase activity" is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004511 name: tyrosine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2] synonym: "L-tyrosine hydroxylase activity" EXACT [EC:1.14.16.2] synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.2] synonym: "tyrosine 3-hydroxylase activity" EXACT [] synonym: "tyrosine hydroxylase activity" EXACT [] xref: EC:1.14.16.2 xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN xref: Reactome:12282 "tyrosine 3-monooxygenase activity" is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004512 name: inositol-3-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10719] subset: gosubset_prok synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" EXACT [EC:5.5.1.4] synonym: "D-glucose 6-phosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucocycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucose 6-phosphate cyclase activity" EXACT [EC:5.5.1.4] synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthatase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthetase activity" EXACT [EC:5.5.1.4] synonym: "myo-inositol-1-phosphate synthase activity" EXACT [] xref: EC:5.5.1.4 xref: KEGG:R07324 xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN xref: Reactome:12283 "inositol-3-phosphate synthase activity" xref: RHEA:10719 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0004513 name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10] synonym: "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "SAT-3" RELATED [EC:2.4.99.10] synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10] xref: EC:2.4.99.10 xref: MetaCyc:2.4.99.10-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0004514 name: nicotinate-nucleotide diphosphorylase (carboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [EC:2.4.2.19, RHEA:12736] subset: gosubset_prok synonym: "NAD pyrophosphorylase activity" EXACT [EC:2.4.2.19] synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT [] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "QAPRTase activity" EXACT [EC:2.4.2.19] synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" EXACT [EC:2.4.2.19] synonym: "quinolinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] synonym: "quinolinic phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] xref: EC:2.4.2.19 xref: KEGG:R03348 xref: MetaCyc:QUINOPRIBOTRANS-RXN xref: Reactome:12286 "nicotinate-nucleotide diphosphorylase (carboxylating) activity" xref: RHEA:12736 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004515 name: nicotinate-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18] subset: gosubset_prok synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) diphosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "NaMN-ATase activity" EXACT [EC:2.7.7.18] synonym: "nicotinate mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW [] xref: EC:2.7.7.18 xref: MetaCyc:NICONUCADENYLYLTRAN-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004516 name: nicotinate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [EC:2.4.2.11, RHEA:13396] subset: gosubset_prok synonym: "niacin ribonucleotidase activity" EXACT [EC:2.4.2.11] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.11] synonym: "nicotinic acid mononucleotide glycohydrolase activity" EXACT [EC:2.4.2.11] synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.11] synonym: "nicotinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.11] xref: EC:2.4.2.11 xref: KEGG:R01724 xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN xref: Reactome:12293 "nicotinate phosphoribosyltransferase activity" xref: RHEA:13396 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004517 name: nitric-oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39] subset: gosubset_prok synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39] synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39] synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" EXACT [EC:1.14.13.39] synonym: "NADPH-diaphorase activity" EXACT [EC:1.14.13.39] synonym: "nitric oxide synthase activity" EXACT [] synonym: "nitric oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "nitric-oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "NO synthase activity" EXACT [EC:1.14.13.39] xref: EC:1.14.13.39 xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN xref: Reactome:12296 "nitric-oxide synthase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004518 name: nuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. subset: goslim_plant subset: gosubset_prok xref: EC:3.1.-.- is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0004519 name: endonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: Reactome:3138 "endonuclease activity" is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004520 name: endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "DNA nicking activity" RELATED [GOC:mah] synonym: "endonuclease G activity" RELATED [] xref: Reactome:3136 "endodeoxyribonuclease activity" is_a: GO:0004519 ! endonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0004521 name: endoribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "endonuclease G activity" RELATED [] xref: Reactome:3196 "endoribonuclease activity" is_a: GO:0004519 ! endonuclease activity is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0004522 name: pancreatic ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.5] synonym: "alkaline ribonuclease activity" EXACT [EC:3.1.27.5] synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT [EC:3.1.27.5] synonym: "endoribonuclease I" RELATED [EC:3.1.27.5] synonym: "gene S glycoproteins" RELATED [EC:3.1.27.5] synonym: "gene S locus-specific glycoproteins" RELATED [EC:3.1.27.5] synonym: "pancreatic RNase activity" EXACT [EC:3.1.27.5] synonym: "ribonuclease A" EXACT [] synonym: "ribonuclease I activity" EXACT [EC:3.1.27.5] synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT [EC:3.1.27.5] synonym: "ribonucleic phosphatase activity" EXACT [EC:3.1.27.5] synonym: "RNase A activity" EXACT [EC:3.1.27.5] synonym: "RNase activity" BROAD [EC:3.1.27.5] synonym: "RNase I activity" EXACT [EC:3.1.27.5] synonym: "S-genotype-assocd. glycoproteins" RELATED [EC:3.1.27.5] synonym: "SLSG glycoproteins" RELATED [EC:3.1.27.5] xref: EC:3.1.27.5 xref: MetaCyc:3.1.27.5-RXN xref: Wikipedia:Ribonuclease_A is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0004523 name: ribonuclease H activity namespace: molecular_function alt_id: GO:0004524 def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. subset: gosubset_prok synonym: "calf thymus ribonuclease H activity" EXACT [] synonym: "endoribonuclease H" RELATED [EC:3.1.26.4] synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4] synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4] synonym: "hybrid nuclease activity" EXACT [EC:3.1.26.4] synonym: "hybrid ribonuclease activity" EXACT [EC:3.1.26.4] synonym: "hybridase (ribonuclease H)" EXACT [EC:3.1.26.4] synonym: "hybridase activity" EXACT [EC:3.1.26.4] synonym: "ribonuclease H1 activity" NARROW [] synonym: "ribonuclease H2 activity" NARROW [] synonym: "ribonuclease H3 activity" NARROW [] synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" EXACT [EC:3.1.26.4] synonym: "RNase H activity" EXACT [] synonym: "RNase H1 activity" NARROW [] synonym: "RNase H2 activity" NARROW [] synonym: "RNase H3 activity" NARROW [] xref: EC:3.1.26.4 xref: MetaCyc:3.1.26.4-RXN xref: Reactome:12321 "ribonuclease H activity" is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004525 name: ribonuclease III activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] subset: gosubset_prok synonym: "pre-mRNA 3'-end processing endonuclease" NARROW [] synonym: "ribonuclease 3 activity" EXACT [EC:3.1.26.3] synonym: "RNase III activity" EXACT [EC:3.1.26.3] xref: EC:3.1.26.3 xref: MetaCyc:3.1.26.3-RXN xref: Reactome:12326 "ribonuclease III activity" is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004526 name: ribonuclease P activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] subset: gosubset_prok synonym: "RNase P" EXACT [] synonym: "tRNA 5' leader endonuclease activity" EXACT [] xref: EC:3.1.26.5 xref: MetaCyc:3.1.26.5-RXN xref: Wikipedia:RNase_P is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004527 name: exonuclease activity namespace: molecular_function alt_id: GO:0008857 def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "exonuclease IX activity" NARROW [] is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004528 name: phosphodiesterase I activity namespace: molecular_function def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1] subset: gosubset_prok synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1] synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1] synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDE activity" RELATED [EC:3.1.4.1] synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'NPDE activity" RELATED [EC:3.1.4.1] synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "exonuclease I activity" RELATED [EC:3.1.4.1] synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "oligonucleate 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.1] synonym: "orthophosphoric diester phosphohydrolase activity" EXACT [EC:3.1.4.1] synonym: "PDE I activity" EXACT [EC:3.1.4.1] synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1] xref: EC:3.1.4.1 xref: MetaCyc:3.1.4.1-RXN is_a: GO:0004527 ! exonuclease activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004529 name: exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok is_a: GO:0004527 ! exonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0004530 name: deoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1] subset: gosubset_prok synonym: "alkaline deoxyribonuclease activity" EXACT [EC:3.1.21.1] synonym: "alkaline DNase activity" EXACT [EC:3.1.21.1] synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1] synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1] synonym: "deoxyribonucleic phosphatase activity" EXACT [EC:3.1.21.1] synonym: "DNA depolymerase activity" EXACT [EC:3.1.21.1] synonym: "DNA endonuclease activity" EXACT [EC:3.1.21.1] synonym: "DNA nuclease activity" EXACT [EC:3.1.21.1] synonym: "DNAase activity" EXACT [EC:3.1.21.1] synonym: "DNase activity" NARROW [EC:3.1.21.1] synonym: "DNase I" RELATED [EC:3.1.21.1] synonym: "dornava" RELATED [EC:3.1.21.1] synonym: "dornavac" RELATED [EC:3.1.21.1] synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1] synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1] synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1] synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1] synonym: "pancreatic dornase" NARROW [EC:3.1.21.1] synonym: "thymonuclease activity" NARROW [EC:3.1.21.1] synonym: "thymonuclease, dornase activity" EXACT [EC:3.1.21.1] xref: EC:3.1.21.1 xref: MetaCyc:3.1.21.1-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004531 name: deoxyribonuclease II activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1] subset: gosubset_prok synonym: "acid deoxyribonuclease activity" EXACT [EC:3.1.22.1] synonym: "acid DNase activity" EXACT [EC:3.1.22.1] synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.22.1] synonym: "DNase II activity" EXACT [EC:3.1.22.1] synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1] synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1] xref: EC:3.1.22.1 xref: MetaCyc:3.1.22.1-RXN is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0004532 name: exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: Reactome:3228 "exoribonuclease activity" is_a: GO:0004527 ! exonuclease activity is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0004533 name: exoribonuclease H activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684] synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2] xref: EC:3.1.13.2 xref: MetaCyc:3.1.13.2-RXN is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004534 name: 5'-3' exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] xref: EC:3.1.13.- xref: Reactome:12364 "5'-3' exoribonuclease activity" is_a: GO:0008409 ! 5'-3' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004535 name: poly(A)-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] synonym: "2',3'-exoribonuclease activity" RELATED [EC:3.1.13.4] synonym: "3'-exoribonuclease activity" EXACT [EC:3.1.13.4] synonym: "poly(A)-specific RNase activity" EXACT [] xref: EC:3.1.13.4 xref: MetaCyc:3.1.13.4-RXN xref: Reactome:12368 "poly(A)-specific ribonuclease activity" is_a: GO:0000175 ! 3'-5'-exoribonuclease activity [Term] id: GO:0004536 name: deoxyribonuclease activity namespace: molecular_function alt_id: GO:0004537 def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "caspase-activated deoxyribonuclease activity" NARROW [] xref: Reactome:1811 "deoxyribonuclease activity" is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004540 name: ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] subset: gosubset_prok is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004549 name: tRNA-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah] subset: gosubset_prok synonym: "tRNA-specific RNase activity" EXACT [] is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0004550 name: nucleoside diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] subset: gosubset_prok synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "NDK activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphate (UDP) kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphokinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside-diphosphate kinase activity" EXACT [] synonym: "nucleotide phosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "UDP kinase activity" EXACT [EC:2.7.4.6] synonym: "uridine diphosphate kinase activity" EXACT [EC:2.7.4.6] xref: EC:2.7.4.6 xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN xref: Reactome:12403 "nucleoside diphosphate kinase activity" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: GO:0004551 name: nucleotide diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9] subset: gosubset_prok synonym: "dinucleotide nucleotidohydrolase activity" EXACT [EC:3.6.1.9] synonym: "nucleotide pyrophosphatase activity" EXACT [] synonym: "nucleotide-sugar pyrophosphatase activity" EXACT [EC:3.6.1.9] xref: EC:3.6.1.9 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN xref: Reactome:12405 "nucleotide diphosphatase activity" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004552 name: octanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH." [EC:1.1.1.73, RHEA:24623] synonym: "1-octanol dehydrogenase activity" EXACT [EC:1.1.1.73] synonym: "octanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.73] xref: EC:1.1.1.73 xref: KEGG:R02878 xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN xref: RHEA:24623 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004553 name: hydrolase activity, hydrolyzing O-glycosyl compounds namespace: molecular_function alt_id: GO:0016800 def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] subset: gosubset_prok synonym: "O-glucosyl hydrolase activity" EXACT [] xref: EC:3.2.1 is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] id: GO:0004555 name: alpha,alpha-trehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28] subset: gosubset_prok synonym: "alpha,alpha-trehalose glucohydrolase activity" EXACT [EC:3.2.1.28] xref: EC:3.2.1.28 xref: MetaCyc:TREHALA-RXN xref: Reactome:12414 "alpha,alpha-trehalase activity" is_a: GO:0015927 ! trehalase activity [Term] id: GO:0004556 name: alpha-amylase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units." [EC:3.2.1.1] subset: gosubset_prok synonym: "1,4-alpha-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.1] synonym: "alpha amylase activity" EXACT [EC:3.2.1.1] synonym: "endoamylase activity" EXACT [EC:3.2.1.1] synonym: "glycogenase activity" BROAD [EC:3.2.1.1] synonym: "taka-amylase A" RELATED [EC:3.2.1.1] xref: EC:3.2.1.1 xref: MetaCyc:ALPHA-AMYL-RXN xref: MetaCyc:RXN-1823 xref: MetaCyc:RXN-1825 xref: Reactome:12418 "alpha-amylase activity" is_a: GO:0016160 ! amylase activity [Term] id: GO:0004557 name: alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22] subset: gosubset_prok synonym: "alpha-D-galactosidase activity" EXACT [EC:3.2.1.22] synonym: "alpha-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22] synonym: "alpha-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "melibiase activity" EXACT [] xref: EC:3.2.1.22 xref: MetaCyc:ALPHAGALACTOSID-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0004558 name: alpha-glucosidase activity namespace: molecular_function alt_id: GO:0004562 alt_id: GO:0016982 def: "Catalysis of the hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20] subset: gosubset_prok synonym: "acid maltase activity" EXACT [EC:3.2.1.20] synonym: "alpha-1,4-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucopyranosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucosidase II" RELATED [] synonym: "alpha-glucoside hydrolase activity" EXACT [EC:3.2.1.20] synonym: "glucoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidosucrase activity" EXACT [EC:3.2.1.20] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20] synonym: "maltase-glucoamylase activity" EXACT [EC:3.2.1.20] xref: EC:3.2.1.20 xref: MetaCyc:MALTODEXGLUCOSID-RXN xref: Reactome:12426 "alpha-glucosidase activity" is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004559 name: alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24] subset: gosubset_prok synonym: "1,2-alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.24] synonym: "alpha-D-mannopyranosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.24] synonym: "exo-alpha-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "p-nitrophenyl-alpha-mannosidase activity" EXACT [EC:3.2.1.24] xref: EC:3.2.1.24 xref: MetaCyc:3.2.1.24-RXN xref: Reactome:12428 "alpha-mannosidase activity" is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0004560 name: alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51] subset: gosubset_prok synonym: "alpha-fucosidase activity" EXACT [EC:3.2.1.51] synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51] xref: EC:3.2.1.51 xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN is_a: GO:0015928 ! fucosidase activity [Term] id: GO:0004561 name: alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50] synonym: "alpha-acetylglucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-D-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "NAG activity" EXACT [EC:3.2.1.50] xref: EC:3.2.1.50 xref: MetaCyc:3.2.1.50-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004563 name: beta-N-acetylhexosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52] subset: gosubset_prok synonym: "beta-acetylaminodeoxyhexosidase activity" EXACT [EC:3.2.1.52] synonym: "beta-acetylhexosaminidinase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" EXACT [EC:3.2.1.52] synonym: "hexosaminidase A" RELATED [EC:3.2.1.52] synonym: "N-acetyl-beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] xref: EC:3.2.1.52 xref: MetaCyc:3.2.1.52-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004564 name: beta-fructofuranosidase activity namespace: molecular_function def: "Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985] subset: gosubset_prok synonym: "acid invertase activity" BROAD [] synonym: "alkaline invertase activity" BROAD [] synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT [] synonym: "beta-fructosidase activity" RELATED [] synonym: "beta-h-fructosidase activity" RELATED [] synonym: "fructosylinvertase activity" RELATED [] synonym: "glucosucrase activity" RELATED [] synonym: "invertase activity" BROAD [] synonym: "invertin activity" BROAD [] synonym: "maxinvert L 1000 activity" RELATED [] synonym: "saccharase activity" RELATED [] xref: EC:3.2.1.26 xref: MetaCyc:RXN-9985 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004565 name: beta-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23] comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase. subset: gosubset_prok synonym: "beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "beta-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "exo-(1->4)-beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "hydrolact" RELATED [EC:3.2.1.23] synonym: "lactose hydrolysis" RELATED [] synonym: "lactozym" RELATED [EC:3.2.1.23] synonym: "maxilact" RELATED [EC:3.2.1.23] synonym: "oryzatym" RELATED [EC:3.2.1.23] synonym: "S 2107" RELATED [EC:3.2.1.23] synonym: "sumiklat" RELATED [EC:3.2.1.23] synonym: "trilactase activity" EXACT [EC:3.2.1.23] xref: EC:3.2.1.23 xref: MetaCyc:3.2.1.23-RXN xref: MetaCyc:BGALACT-PWY is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0004566 name: beta-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31] subset: gosubset_prok synonym: "beta-D-glucuronoside glucuronosohydrolase activity" EXACT [EC:3.2.1.31] synonym: "beta-glucuronide glucuronohydrolase activity" EXACT [EC:3.2.1.31] synonym: "exo-beta-D-glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "ketodase activity" EXACT [EC:3.2.1.31] xref: EC:3.2.1.31 xref: MetaCyc:BETA-GLUCURONID-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004567 name: beta-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25] subset: gosubset_prok synonym: "beta-D-mannosidase activity" EXACT [EC:3.2.1.25] synonym: "beta-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "beta-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "exo-beta-D-mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannase activity" EXACT [EC:3.2.1.25] xref: EC:3.2.1.25 xref: MetaCyc:3.2.1.25-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0004568 name: chitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] subset: gosubset_prok synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" EXACT [EC:3.2.1.14] synonym: "chitodextrinase activity" EXACT [EC:3.2.1.14] synonym: "poly-beta-glucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" EXACT [EC:3.2.1.14] xref: EC:3.2.1.14 xref: MetaCyc:3.2.1.14-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004569 name: glycoprotein endo-alpha-1,2-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130] synonym: "endo-alpha-mannosidase activity" EXACT [EC:3.2.1.130] synonym: "endomannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosyl mannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosylmannosidase activity" EXACT [EC:3.2.1.130] synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130] xref: EC:3.2.1.130 xref: MetaCyc:3.2.1.130-RXN xref: Reactome:12466 "glycoprotein endo-alpha-1,2-mannosidase activity" is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0004571 name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113] subset: gosubset_prok synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.113] synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.113] synonym: "exo-alpha-1,2-mannanase activity" EXACT [EC:3.2.1.113] synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113] synonym: "man9-mannosidase activity" RELATED [EC:3.2.1.113] synonym: "Man9-mannosidase activity" EXACT [EC:3.2.1.113] synonym: "ManI activity" NARROW [EC:3.2.1.113] synonym: "mannose-9 processing alpha-mannosidase activity" EXACT [EC:3.2.1.113] synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113] synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113] synonym: "mannosidase I" RELATED [EC:3.2.1.113] xref: EC:3.2.1.113 xref: MetaCyc:3.2.1.113-RXN xref: Reactome:12478 "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity" is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity [Term] id: GO:0004572 name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal 1,3- and 1,6-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114] synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.114] synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114] synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "alpha1-3,6-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "exo-1,3-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" EXACT [EC:3.2.1.114] synonym: "Golgi alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "ManII activity" NARROW [EC:3.2.1.114] synonym: "mannosidase II activity" NARROW [EC:3.2.1.114] xref: EC:3.2.1.114 xref: MetaCyc:3.2.1.114-RXN xref: Reactome:12483 "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity" is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity [Term] id: GO:0004573 name: mannosyl-oligosaccharide glucosidase activity namespace: molecular_function def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106] synonym: "Glc3Man9NAc2 oligosaccharide glucosidase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucohydrolase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT [] synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106] synonym: "trimming glucosidase I" RELATED [EC:3.2.1.106] xref: EC:3.2.1.106 xref: MetaCyc:3.2.1.106-RXN xref: Reactome:12487 "mannosyl-oligosaccharide glucosidase activity" is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004574 name: oligo-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose." [EC:3.2.1.10] subset: gosubset_prok synonym: "alpha-limit dextrinase activity" EXACT [EC:3.2.1.10] synonym: "dextrin 6-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "dextrin 6alpha-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "exo-oligo-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "isomaltase activity" RELATED [EC:3.2.1.10] synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10] xref: EC:3.2.1.10 xref: MetaCyc:3.2.1.10-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004575 name: sucrose alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose." [EC:3.2.1.48, MetaCyc:RXN-1461] synonym: "alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis" BROAD [] synonym: "beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis" BROAD [] synonym: "intestinal sucrase activity" RELATED [EC:3.2.1.48] synonym: "sucrase activity" RELATED [EC:3.2.1.48] synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48] synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.48] synonym: "sucrose alpha-D-glucohydrolase activity" EXACT [] synonym: "sucrose alpha-glucohydrolase activity" EXACT [EC:3.2.1.48] synonym: "sucrose hydrolysis" BROAD [] synonym: "sucrose-alpha-D-glucohydrolase activity" EXACT [EC:3.2.1.48] xref: EC:3.2.1.26 xref: EC:3.2.1.48 xref: KEGG:R00802 xref: MetaCyc:RXN-1461 xref: Reactome:12493 "sucrose alpha-glucosidase activity" is_a: GO:0004558 ! alpha-glucosidase activity is_a: GO:0004564 ! beta-fructofuranosidase activity [Term] id: GO:0004576 name: oligosaccharyl transferase activity namespace: molecular_function def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok synonym: "oligosaccharide transferase activity" EXACT [EC:2.4.1.119, GOC:mah] xref: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004577 name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141] synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.4.1.141] synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.141] synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.141] synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.141] xref: EC:2.4.1.141 xref: MetaCyc:2.4.1.141-RXN xref: Reactome:12497 "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004578 name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142] synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] xref: EC:2.4.1.142 xref: MetaCyc:2.4.1.142-RXN xref: Reactome:12498 "chitobiosyldiphosphodolichol beta-mannosyltransferase activity" is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity [Term] id: GO:0004579 name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119] synonym: "asparagine N-glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT [] synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "oligomannosyltransferase activity" RELATED [EC:2.4.1.119] xref: EC:2.4.1.119 xref: MetaCyc:2.4.1.119-RXN xref: Reactome:12500 "dolichyl-diphosphooligosaccharide-protein glycotransferase activity" is_a: GO:0004576 ! oligosaccharyl transferase activity [Term] id: GO:0004581 name: dolichyl-phosphate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117] subset: gosubset_prok synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" EXACT [EC:2.4.1.117] xref: EC:2.4.1.117 xref: MetaCyc:2.4.1.117-RXN xref: Reactome:12517 "dolichyl-phosphate beta-glucosyltransferase activity" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0004582 name: dolichyl-phosphate beta-D-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83] subset: gosubset_prok synonym: "dolichol phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate-mannose synthase activity" EXACT [] synonym: "dolichyl mannosyl phosphate synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phospho-mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "DPM synthase activity" EXACT [] synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPMan:DolP mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphodolichol synthase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphoryldolichol synthase activity" EXACT [EC:2.4.1.83] xref: EC:2.4.1.83 xref: MetaCyc:2.4.1.83-RXN xref: Reactome:12521 "dolichyl-phosphate beta-D-mannosyltransferase activity" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004583 name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [GOC:mah] xref: EC:2.4.1.- xref: MetaCyc:RXN-5472 xref: Reactome:12525 "dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity" is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0004584 name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130] synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "oligomannosylsynthase activity" EXACT [EC:2.4.1.130] xref: EC:2.4.1.130 xref: MetaCyc:2.4.1.130-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004585 name: ornithine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3] subset: gosubset_prok synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "carbamylphosphate-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "citrulline phosphorylase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "OTC activity" EXACT [EC:2.1.3.3] synonym: "OTCase activity" EXACT [EC:2.1.3.3] xref: EC:2.1.3.3 xref: MetaCyc:ORNCARBAMTRANSFER-RXN xref: Reactome:12530 "ornithine carbamoyltransferase activity" is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0004586 name: ornithine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine." [EC:4.1.1.17, RHEA:22967] subset: gosubset_prok synonym: "L-ornithine carboxy-lyase (putrescine-forming)" EXACT [EC:4.1.1.17] synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17] synonym: "SpeC" RELATED [EC:4.1.1.17] xref: EC:4.1.1.17 xref: KEGG:R00670 xref: MetaCyc:ORNDECARBOX-RXN xref: Reactome:12531 "ornithine decarboxylase activity" xref: RHEA:22967 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004587 name: ornithine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13] subset: gosubset_prok synonym: "GabT" RELATED [EC:2.6.1.13] synonym: "L-ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "OAT" RELATED [EC:2.6.1.13] synonym: "ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine delta-transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine ketoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--2-oxoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo-acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine-oxo-acid aminotransferase activity" EXACT [] synonym: "ornithine:alpha-oxoglutarate transaminase activity" EXACT [EC:2.6.1.13] xref: EC:2.6.1.13 xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN xref: Reactome:12532 "ornithine-oxo-acid transaminase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004588 name: orotate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10] subset: gosubset_prok synonym: "OPRT activity" EXACT [EC:2.4.2.10] synonym: "OPRTase activity" EXACT [EC:2.4.2.10] synonym: "orotate phosphoribosyl pyrophosphate transferase activity" EXACT [EC:2.4.2.10] synonym: "orotic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate diphosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic pyrophosphorylase activity" EXACT [EC:2.4.2.10] xref: EC:2.4.2.10 xref: MetaCyc:OROPRIBTRANS-RXN xref: Reactome:12534 "orotate phosphoribosyltransferase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004589 name: orotate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate." [EC:1.3.1.14, RHEA:13516] synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.14] xref: EC:1.3.1.14 xref: KEGG:R01869 xref: MetaCyc:OROTATE-REDUCTASE-NADH-RXN xref: RHEA:13516 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004590 name: orotidine-5'-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP." [EC:4.1.1.23, RHEA:11599] subset: gosubset_prok synonym: "ODCase activity" EXACT [EC:4.1.1.23] synonym: "OMP decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "OMP-DC" RELATED [EC:4.1.1.23] synonym: "OMPdcase activity" EXACT [EC:4.1.1.23] synonym: "orotate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotate monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine 5'-phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic acid decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotodylate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "UMP synthase activity" EXACT [EC:4.1.1.23] synonym: "uridine 5'-monophosphate synthase activity" EXACT [EC:4.1.1.23] xref: EC:4.1.1.23 xref: KEGG:R00965 xref: MetaCyc:OROTPDECARB-RXN xref: Reactome:12548 "orotidine-5'-phosphate decarboxylase activity" xref: RHEA:11599 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004591 name: oxoglutarate dehydrogenase (succinyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2] subset: gosubset_prok synonym: "2-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate: lipoate oxidoreductase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" EXACT [EC:1.2.4.2] synonym: "AKGDH activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric acid dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "OGDC activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate decarboxylase activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT [] synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] xref: EC:1.2.4.2 xref: MetaCyc:2OXOGLUTDECARB-RXN is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0004592 name: pantoate-beta-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1] subset: gosubset_prok synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantothenate synthetase activity" EXACT [EC:6.3.2.1] xref: EC:6.3.2.1 xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004593 name: pantothenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine." [EC:3.5.1.22, RHEA:12451] synonym: "(R)-pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate hydrolase activity" EXACT [EC:3.5.1.22] xref: EC:3.5.1.22 xref: KEGG:R02474 xref: MetaCyc:PANTOTHENASE-RXN xref: RHEA:12451 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004594 name: pantothenate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33] subset: gosubset_prok synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "ATP:pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "D-pantothenate kinase activity" EXACT [EC:2.7.1.33] synonym: "pantothenate kinase (phosphorylating) activity" EXACT [EC:2.7.1.33] synonym: "pantothenic acid kinase activity" EXACT [EC:2.7.1.33] xref: EC:2.7.1.33 xref: MetaCyc:PANTOTHENATE-KIN-RXN xref: Reactome:12562 "pantothenate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004595 name: pantetheine-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate." [EC:2.7.7.3, RHEA:19804] subset: gosubset_prok synonym: "3'-dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT [] synonym: "dephospho-CoA diphosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-coenzyme A pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "pantetheine phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "phosphopantetheine adenylyltransferase activity" EXACT [] synonym: "PPAT activity" EXACT [EC:2.7.7.3] xref: EC:2.7.7.3 xref: KEGG:R03035 xref: MetaCyc:PANTEPADENYLYLTRAN-RXN xref: Reactome:12566 "pantetheine-phosphate adenylyltransferase activity" xref: RHEA:19804 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004596 name: peptide alpha-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [EC:2.3.1.88, GOC:mah] subset: gosubset_prok synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [EC:2.3.1.88] synonym: "beta-endorphin acetyltransferase activity" NARROW [EC:2.3.1.88] synonym: "N(alpha)-acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "NAT activity" RELATED [EC:2.3.1.88] synonym: "peptide acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "protein N-terminal acetyltransferase activity" EXACT [EC:2.3.1.88] xref: EC:2.3.1.88 xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN is_a: GO:0034212 ! peptide N-acetyltransferase activity [Term] id: GO:0004597 name: peptide-aspartate beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16] subset: gosubset_prok synonym: "aspartate beta-hydroxylase activity" EXACT [EC:1.14.11.16] synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16] synonym: "aspartylpeptide beta-dioxygenase activity" EXACT [EC:1.14.11.16] synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.16] xref: EC:1.14.11.16 xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0004598 name: peptidylamidoglycolate lyase activity namespace: molecular_function def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5] synonym: "alpha-hydroxyglycine amidating dealkylase activity" EXACT [EC:4.3.2.5] synonym: "HGAD" RELATED [EC:4.3.2.5] synonym: "PAL" RELATED [EC:4.3.2.5] synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5] synonym: "PGL" RELATED [EC:4.3.2.5] xref: EC:4.3.2.5 xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004600 name: cyclophilin namespace: molecular_function def: "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003755 consider: GO:0016018 [Term] id: GO:0004601 name: peroxidase activity namespace: molecular_function alt_id: GO:0016685 alt_id: GO:0016686 alt_id: GO:0016687 alt_id: GO:0016693 def: "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] subset: gosubset_prok synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7] synonym: "eosinophil peroxidase activity" NARROW [] synonym: "extensin peroxidase" NARROW [EC:1.11.1.7] synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7] synonym: "heme peroxidase" NARROW [EC:1.11.1.7] synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7] synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7] synonym: "lactoperoxidase activity" NARROW [] synonym: "MPO" RELATED [EC:1.11.1.7] synonym: "myeloperoxidase activity" NARROW [] synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7] synonym: "peroxidase reaction" EXACT [] synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7] synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7] synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7] synonym: "secretory plant peroxidase activity" NARROW [] synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7] synonym: "verdoperoxidase" NARROW [EC:1.11.1.7] xref: EC:1.11.1.7 xref: KEGG:R03532 xref: MetaCyc:PEROXID-RXN xref: Reactome:4411 "peroxidase activity" xref: RHEA:23637 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor [Term] id: GO:0004602 name: glutathione peroxidase activity namespace: molecular_function alt_id: GO:0016224 def: "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] subset: gosubset_prok synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.9] synonym: "GSH peroxidase activity" EXACT [EC:1.11.1.9] synonym: "non-selenium glutathione peroxidase activity" NARROW [] synonym: "reduced glutathione peroxidase activity" EXACT [EC:1.11.1.9] synonym: "selenium-glutathione peroxidase activity" EXACT [EC:1.11.1.9] xref: EC:1.11.1.9 xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN xref: Reactome:13237 "glutathione peroxidase activity" is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004603 name: phenylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28] synonym: "noradrenalin N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28] synonym: "norepinephrine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "norepinephrine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] xref: EC:2.1.1.28 xref: MetaCyc:2.1.1.28-RXN xref: Reactome:13238 "phenylethanolamine N-methyltransferase activity" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004604 name: phosphoadenylyl-sulfate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8, RHEA:11727] subset: gosubset_prok synonym: "3'-phosphoadenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "PAdoPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase, thioredoxin-dependent activity" EXACT [EC:1.8.4.8] synonym: "PAPS sulfotransferase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenosine-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT [] synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] xref: EC:1.8.4.8 xref: KEGG:R02021 xref: MetaCyc:1.8.4.8-RXN xref: Reactome:13241 "phosphoadenylyl-sulfate reductase (thioredoxin) activity" xref: RHEA:11727 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0004605 name: phosphatidate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41] subset: gosubset_prok synonym: "CDP diglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "CDP-DG" RELATED [EC:2.7.7.41] synonym: "CDP-diacylglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CDP-diacylglycerol synthase activity" EXACT [] synonym: "CDP-diglyceride diphosphorylase activity" EXACT [] synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT [] synonym: "CDP-diglyceride synthase activity" EXACT [] synonym: "CDP-diglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP-diacylglycerol synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" EXACT [EC:2.7.7.41] synonym: "CTP:phosphatidate cytidylyltransferase activity" EXACT [EC:2.7.7.41] synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "DAG synthetase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidate cytidyltransferase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidic acid cytidylyltransferase activity" EXACT [EC:2.7.7.41] xref: EC:2.7.7.41 xref: MetaCyc:CDPDIGLYSYN-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004607 name: phosphatidylcholine-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43] subset: gosubset_prok synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43] synonym: "LCAT activity" EXACT [EC:2.3.1.43] synonym: "lecithin--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "lecithin:cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phosphatidylcholine:sterol O-acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] xref: EC:2.3.1.43 xref: MetaCyc:2.3.1.43-RXN xref: Reactome:13245 "phosphatidylcholine-sterol O-acyltransferase activity" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004608 name: phosphatidylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17, RHEA:11167] subset: gosubset_prok synonym: "lipid methyl transferase activity" EXACT [EC:2.1.1.17] synonym: "LMTase activity" EXACT [EC:2.1.1.17] synonym: "PEMT" RELATED [EC:2.1.1.17] synonym: "phosphatidylethanolamine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-N-methylase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.17] xref: EC:2.1.1.17 xref: KEGG:R02056 xref: MetaCyc:2.1.1.17-RXN xref: RHEA:11167 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004609 name: phosphatidylserine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine." [EC:4.1.1.65, RHEA:20831] subset: gosubset_prok synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" EXACT [EC:4.1.1.65] synonym: "phosphatidyl-L-serine carboxy-lyase activity" EXACT [EC:4.1.1.65] synonym: "PS decarboxylase activity" EXACT [EC:4.1.1.65] xref: EC:4.1.1.65 xref: KEGG:R02055 xref: MetaCyc:PHOSPHASERDECARB-RXN xref: RHEA:20831 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004610 name: phosphoacetylglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23807] subset: gosubset_prok synonym: "acetylaminodeoxyglucose phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "acetylglucosamine phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetylglucosamine-phosphate mutase activity" EXACT [EC:5.4.2.3] synonym: "phospho-N-acetylglucosamine mutase activity" EXACT [EC:5.4.2.3] xref: EC:5.4.2.3 xref: KEGG:R08193 xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN xref: Reactome:13263 "phosphoacetylglucosamine mutase activity" xref: RHEA:23807 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004611 name: phosphoenolpyruvate carboxykinase activity namespace: molecular_function def: "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products." [EC:4.1.1.-] subset: gosubset_prok synonym: "PEP carboxykinase activity" EXACT [EC:4.1.1.-] synonym: "PEPCK activity" EXACT [EC:4.1.1.-] synonym: "phosphopyruvate carboxylase activity" EXACT [EC:4.1.1.-] xref: EC:4.1.1.- is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004612 name: phosphoenolpyruvate carboxykinase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate." [EC:4.1.1.49, RHEA:18620] subset: gosubset_prok synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.49] synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.49] synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49] synonym: "PEPK" RELATED [EC:4.1.1.49] synonym: "phosphoenolpyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" EXACT [EC:4.1.1.49] synonym: "phosphopyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] xref: EC:4.1.1.49 xref: KEGG:R00341 xref: MetaCyc:PEPCARBOXYKIN-RXN xref: RHEA:18620 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0004613 name: phosphoenolpyruvate carboxykinase (GTP) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32] subset: gosubset_prok synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.32] synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT [] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxykinase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxylase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate carboxylase (GTP)" EXACT [EC:4.1.1.32] xref: EC:4.1.1.32 xref: MetaCyc:4.1.1.32-RXN xref: Reactome:13265 "phosphoenolpyruvate carboxykinase (GTP) activity" is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0004614 name: phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2] subset: gosubset_prok synonym: "alpha-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "glucose phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "phosphoglucose mutase activity" EXACT [EC:5.4.2.2] xref: EC:5.4.2.2 xref: MetaCyc:PHOSPHOGLUCMUT-RXN xref: Reactome:13266 "phosphoglucomutase activity" is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004615 name: phosphomannomutase activity namespace: molecular_function alt_id: GO:0008971 def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8, RHEA:11143] subset: gosubset_prok synonym: "alpha-D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "mannose phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "phosphomannose mutase activity" EXACT [EC:5.4.2.8] xref: EC:5.4.2.8 xref: KEGG:R01818 xref: MetaCyc:PHOSMANMUT-RXN xref: Reactome:13267 "phosphomannomutase activity" xref: RHEA:11143 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004616 name: phosphogluconate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] subset: gosubset_prok synonym: "6-phospho-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.44] synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic carboxylase activity" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44] synonym: "6PGD activity" EXACT [EC:1.1.1.44] synonym: "phosphogluconic acid dehydrogenase activity" EXACT [EC:1.1.1.44] xref: EC:1.1.1.44 xref: MetaCyc:6PGLUCONDEHYDROG-RXN xref: Reactome:13269 "phosphogluconate dehydrogenase (decarboxylating) activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004617 name: phosphoglycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] subset: gosubset_prok synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3PHP reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-KG reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "alphaKG reductase activity" EXACT [EC:1.1.1.95] synonym: "D- and L-HGA" RELATED [EC:1.1.1.95] synonym: "D-3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "glycerate 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "glycerate-1,3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "PGDH activity" EXACT [EC:1.1.1.95] synonym: "phosphoglycerate oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "SerA" RELATED [EC:1.1.1.95] synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95] xref: EC:1.1.1.95 xref: MetaCyc:PGLYCDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004618 name: phosphoglycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [EC:2.7.2.3, RHEA:14804] subset: gosubset_prok synonym: "3-PGK" RELATED [EC:2.7.2.3] synonym: "3-phosphoglycerate kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglycerate phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "glycerate 3-phosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "glycerophosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "PGK" RELATED [EC:2.7.2.3] synonym: "phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglycerokinase activity" EXACT [EC:2.7.2.3] xref: EC:2.7.2.3 xref: KEGG:R01512 xref: MetaCyc:PHOSGLYPHOS-RXN xref: Reactome:13282 "phosphoglycerate kinase activity" xref: RHEA:14804 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0004619 name: phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] subset: gosubset_prok synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1] synonym: "D-phosphoglycerate 2,3-phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1] synonym: "GriP mutase" NARROW [EC:5.4.2.1] synonym: "monophosphoglycerate mutase activity" EXACT [EC:5.4.2.1] synonym: "monophosphoglyceromutase activity" EXACT [EC:5.4.2.1] synonym: "MPGM" RELATED [EC:5.4.2.1] synonym: "PGA mutase activity" EXACT [EC:5.4.2.1] synonym: "PGAM activity" EXACT [EC:5.4.2.1] synonym: "PGM" EXACT [] synonym: "phosphoglycerate phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "phosphoglyceromutase activity" EXACT [EC:5.4.2.1] xref: EC:5.4.2.1 xref: MetaCyc:3PGAREARR-RXN xref: Reactome:13285 "phosphoglycerate mutase activity" is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004620 name: phospholipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.1.1.- is_a: GO:0016298 ! lipase activity [Term] id: GO:0004621 name: glycosylphosphatidylinositol phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50] synonym: "glycoprotein phospholipase D activity" EXACT [] synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" EXACT [EC:3.1.4.50] synonym: "GPI-PLD activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-specific phospholipase D activity" EXACT [EC:3.1.4.50] xref: EC:3.1.4.50 xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN is_a: GO:0004630 ! phospholipase D activity [Term] id: GO:0004622 name: lysophospholipase activity namespace: molecular_function alt_id: GO:0045126 def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] subset: gosubset_prok synonym: "2-lysophosphatidylcholine acylhydrolase activity" EXACT [EC:3.1.1.5] synonym: "lecithinase B activity" EXACT [EC:3.1.1.5] synonym: "lecitholipase activity" EXACT [EC:3.1.1.5] synonym: "lysolecithinase activity" EXACT [EC:3.1.1.5] synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5] synonym: "lysophosphatidase activity" EXACT [EC:3.1.1.5] synonym: "lysophosphatidylcholine hydrolase activity" EXACT [EC:3.1.1.5] synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5] synonym: "phosphatidase B" RELATED [EC:3.1.1.5] synonym: "phospholipase B activity" EXACT [EC:3.1.1.5] xref: EC:3.1.1.5 xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004623 name: phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] subset: gosubset_prok synonym: "cytosolic phospholipase A2 activity" NARROW [] synonym: "lecithinase A activity" EXACT [EC:3.1.1.4] synonym: "phosphatidase activity" RELATED [EC:3.1.1.4] synonym: "phosphatidolipase activity" EXACT [EC:3.1.1.4] synonym: "phosphatidylcholine 2-acylhydrolase activity" EXACT [EC:3.1.1.4] synonym: "phospholipase A" RELATED [EC:3.1.1.4] synonym: "secreted phospholipase A2 activity" NARROW [] xref: EC:3.1.1.4 xref: MetaCyc:PHOSPHOLIPASE-A2-RXN is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004624 name: secreted phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0004623 replaced_by: GO:0005576 [Term] id: GO:0004625 name: calcium-dependent secreted phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0005576 replaced_by: GO:0047498 [Term] id: GO:0004626 name: cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0004623 replaced_by: GO:0005829 [Term] id: GO:0004627 name: calcium-dependent cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0005829 replaced_by: GO:0047498 [Term] id: GO:0004628 name: calcium-independent cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0005829 replaced_by: GO:0047499 [Term] id: GO:0004629 name: phospholipase C activity namespace: molecular_function alt_id: GO:0042298 def: "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah] subset: gosubset_prok synonym: "lecithinase C activity" RELATED [EC:3.1.4.3] synonym: "lipophosphodiesterase C" RELATED [EC:3.1.4.3] synonym: "phosphatidase C" RELATED [EC:3.1.4.3] xref: MetaCyc:PHOSPHOLIPASE-C-RXN xref: Reactome:11457 "phospholipase C activity" is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004630 name: phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4] subset: gosubset_prok synonym: "choline phosphatase activity" EXACT [EC:3.1.4.4] synonym: "lecithinase D activity" EXACT [EC:3.1.4.4] synonym: "lipophosphodiesterase II activity" EXACT [EC:3.1.4.4] synonym: "phosphatidylcholine phosphatidohydrolase activity" EXACT [EC:3.1.4.4] xref: EC:3.1.4.4 xref: MetaCyc:PHOSCHOL-RXN is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004631 name: phosphomevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+)." [EC:2.7.4.2, RHEA:16344] subset: gosubset_prok synonym: "5-phosphomevalonate kinase activity" EXACT [EC:2.7.4.2] synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "ATP:5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate-5-phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonic acid phosphate kinase activity" EXACT [EC:2.7.4.2] xref: EC:2.7.4.2 xref: KEGG:R03245 xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN xref: Reactome:13380 "phosphomevalonate kinase activity" xref: RHEA:16344 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0004632 name: phosphopantothenate--cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5] subset: gosubset_prok synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" EXACT [EC:6.3.2.5] synonym: "phosphopantothenate-cysteine ligase activity" EXACT [] synonym: "phosphopantothenoylcysteine synthetase activity" EXACT [] xref: EC:6.3.2.5 xref: MetaCyc:P-PANTOCYSLIG-RXN xref: Reactome:13381 "phosphopantothenate--cysteine ligase activity" is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004633 name: phosphopantothenoylcysteine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate." [EC:4.1.1.36, RHEA:16796] subset: gosubset_prok synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "4-phosphopantotheoylcysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "PPC-decarboxylase activity" EXACT [EC:4.1.1.36] xref: EC:4.1.1.36 xref: KEGG:R03269 xref: MetaCyc:P-PANTOCYSDECARB-RXN xref: Reactome:13382 "phosphopantothenoylcysteine decarboxylase activity" xref: RHEA:16796 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004634 name: phosphopyruvate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "14-3-2-protein" RELATED [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase activity" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT [] synonym: "2-phosphoglycerate dehydratase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglycerate enolase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglyceric dehydratase activity" EXACT [EC:4.2.1.11] synonym: "enolase activity" EXACT [EC:4.2.1.11] synonym: "gamma-enolase activity" EXACT [EC:4.2.1.11] synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11] synonym: "phosphoenolpyruvate hydratase activity" EXACT [EC:4.2.1.11] xref: EC:4.2.1.11 xref: MetaCyc:2PGADEHYDRAT-RXN xref: Reactome:13384 "phosphopyruvate hydratase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004635 name: phosphoribosyl-AMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide." [EC:3.5.4.19, RHEA:20052] subset: gosubset_prok synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" EXACT [EC:3.5.4.19] synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" EXACT [EC:3.5.4.19] synonym: "PRAMP-cyclohydrolase activity" EXACT [EC:3.5.4.19] xref: EC:3.5.4.19 xref: KEGG:R04037 xref: MetaCyc:HISTCYCLOHYD-RXN xref: RHEA:20052 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0004636 name: phosphoribosyl-ATP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+)." [EC:3.6.1.31, RHEA:22831] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" EXACT [EC:3.6.1.31] synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT [] synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.31] xref: EC:3.6.1.31 xref: KEGG:R04035 xref: MetaCyc:HISTPRATPHYD-RXN xref: RHEA:22831 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004637 name: phosphoribosylamine-glycine ligase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17456] subset: gosubset_prok synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" EXACT [EC:6.3.4.13] synonym: "5'-phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" EXACT [EC:6.3.4.13] synonym: "GAR" RELATED [EC:6.3.4.13] synonym: "GAR synthetase activity" EXACT [EC:6.3.4.13] synonym: "GARS activity" EXACT [EC:6.3.4.13] synonym: "glycinamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "glycineamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycineamide synthetase activity" EXACT [EC:6.3.4.13] xref: EC:6.3.4.13 xref: KEGG:R04144 xref: MetaCyc:GLYRIBONUCSYN-RXN xref: Reactome:13392 "phosphoribosylamine-glycine ligase activity" xref: RHEA:17456 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004638 name: phosphoribosylaminoimidazole carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)." [EC:4.1.1.21, RHEA:10795] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" EXACT [EC:4.1.1.21] synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" EXACT [EC:4.1.1.21] synonym: "ADE2" RELATED [EC:4.1.1.21] synonym: "AIR carboxylase activity" EXACT [EC:4.1.1.21] synonym: "class II PurE" RELATED [EC:4.1.1.21] xref: EC:4.1.1.21 xref: KEGG:R04209 xref: MetaCyc:AIRCARBOXY-RXN xref: Reactome:13396 "phosphoribosylaminoimidazole carboxylase activity" xref: RHEA:10795 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004639 name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate." [EC:6.3.2.6, RHEA:22631] subset: gosubset_prok synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" EXACT [EC:6.3.2.6] synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "PurC" RELATED [EC:6.3.2.6] synonym: "SAICAR synthase activity" EXACT [EC:6.3.2.6] synonym: "SAICAR synthetase activity" EXACT [EC:6.3.2.6] synonym: "SAICARs activity" EXACT [EC:6.3.2.6] xref: EC:6.3.2.6 xref: KEGG:R04591 xref: MetaCyc:SAICARSYN-RXN xref: Reactome:13398 "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity" xref: RHEA:22631 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004640 name: phosphoribosylanthranilate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24, RHEA:21543] subset: gosubset_prok synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24] synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRA isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRAI activity" EXACT [EC:5.3.1.24] xref: EC:5.3.1.24 xref: KEGG:R03509 xref: MetaCyc:PRAISOM-RXN xref: RHEA:21543 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004641 name: phosphoribosylformylglycinamidine cyclo-ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23035] subset: gosubset_prok synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "5'-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIRS activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosyl-aminoimidazole synthetase activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosylaminoimidazole synthetase activity" EXACT [EC:6.3.3.1] xref: EC:6.3.3.1 xref: KEGG:R04208 xref: MetaCyc:AIRS-RXN xref: Reactome:13434 "phosphoribosylformylglycinamidine cyclo-ligase activity" xref: RHEA:23035 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0004642 name: phosphoribosylformylglycinamidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate." [EC:6.3.5.3, RHEA:17132] subset: gosubset_prok synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "FGAM synthase activity" EXACT [EC:6.3.5.3] synonym: "FGAM synthetase activity" EXACT [EC:6.3.5.3] synonym: "FGAR amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "FGARAT activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribonucloetide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribotide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycinamidine synthetase activity" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycineamidine synthetase activity" EXACT [EC:6.3.5.3] xref: EC:6.3.5.3 xref: KEGG:R04463 xref: MetaCyc:FGAMSYN-RXN xref: Reactome:13437 "phosphoribosylformylglycinamidine synthase activity" xref: RHEA:17132 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004643 name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "AICAR formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "AICAR transformylase activity" EXACT [EC:2.1.2.3] synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] xref: EC:2.1.2.3 xref: MetaCyc:AICARTRANSFORM-RXN xref: Reactome:13439 "phosphoribosylaminoimidazolecarboxamide formyltransferase activity" is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004644 name: phosphoribosylglycinamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.2] synonym: "5'-phosphoribosylglycinamide transformylase activity" EXACT [EC:2.1.2.2] synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] synonym: "GAR formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "GAR TFase activity" EXACT [EC:2.1.2.2] synonym: "GAR transformylase activity" EXACT [EC:2.1.2.2] synonym: "GART activity" EXACT [EC:2.1.2.2] synonym: "glycinamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] xref: EC:2.1.2.2 xref: MetaCyc:GART-RXN xref: Reactome:13440 "phosphoribosylglycinamide formyltransferase activity" is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004645 name: phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.1] synonym: "1,4-alpha-glucan phosphorylase activity" EXACT [EC:2.4.1.1] synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1] synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1] synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1] synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1] synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1] synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1] synonym: "myophosphorylase" NARROW [EC:2.4.1.1] synonym: "polyphosphorylase activity" EXACT [EC:2.4.1.1] synonym: "potato phosphorylase" NARROW [EC:2.4.1.1] synonym: "starch phosphorylase" NARROW [EC:2.4.1.1] xref: EC:2.4.1.1 xref: MetaCyc:RXN-1826 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004647 name: phosphoserine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3] subset: gosubset_prok synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3] xref: EC:3.1.3.3 xref: MetaCyc:PSERPHOSPHA-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004648 name: O-phospho-L-serine:2-oxoglutarate aminotransferase activity namespace: molecular_function alt_id: GO:0004646 def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] subset: gosubset_prok synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3PHP transaminase activity" EXACT [EC:2.6.1.52] synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "L-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "PdxC" RELATED [EC:2.6.1.52] synonym: "phosphohydroxypyruvate transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphohydroxypyruvic--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphoserine aminotransferase activity" BROAD [] synonym: "phosphoserine transaminase activity" BROAD [EC:2.6.1.52] synonym: "PSAT activity" EXACT [EC:2.6.1.52] synonym: "SerC" RELATED [EC:2.6.1.52] xref: EC:2.6.1.52 xref: MetaCyc:PSERTRANSAM-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004649 name: poly(ADP-ribose) glycohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143] xref: EC:3.2.1.143 xref: MetaCyc:3.2.1.143-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004650 name: polygalacturonase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15] subset: gosubset_prok synonym: "endo-D-galacturonase activity" EXACT [] synonym: "endo-polygalacturonase activity" EXACT [] synonym: "endogalacturonase activity" EXACT [] synonym: "endopolygalacturonase activity" EXACT [] synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15] synonym: "pectin hydrolase activity" EXACT [EC:3.2.1.15] synonym: "pectin polygalacturonase activity" EXACT [EC:3.2.1.15] synonym: "pectinase activity" NARROW [EC:3.2.1.15] synonym: "pectolase activity" EXACT [EC:3.2.1.15] synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT [] synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT [] xref: EC:3.2.1.15 xref: MetaCyc:RXN-2103 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004651 name: polynucleotide 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] synonym: "5'-polynucleotidase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-phosphohydrolase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33] xref: EC:3.1.3.33 xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN xref: Reactome:13463 "polynucleotide 5'-phosphatase activity" is_a: GO:0019204 ! nucleotide phosphatase activity [Term] id: GO:0004652 name: polynucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19] subset: gosubset_prok synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "AMP polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP-polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "NTP polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) hydrolase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) synthetase activity" EXACT [EC:2.7.7.19] synonym: "poly-A polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate nucleotidyltransferase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate synthetase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic acid polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic polymerase activity" EXACT [EC:2.7.7.19] synonym: "RNA adenylating enzyme activity" EXACT [EC:2.7.7.19] synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19] synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19] xref: EC:2.7.7.19 xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN xref: Reactome:72182 "polynucleotide adenylyltransferase activity" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004653 name: polypeptide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] synonym: "glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "polypeptide-N-acetylgalactosamine transferase activity" EXACT [EC:2.4.1.41] synonym: "protein-UDP acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] xref: EC:2.4.1.41 xref: MetaCyc:2.4.1.41-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0004654 name: polyribonucleotide nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8] subset: gosubset_prok synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" EXACT [EC:2.7.7.8] synonym: "polynucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8] xref: EC:2.7.7.8 xref: MetaCyc:2.7.7.8-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0004655 name: porphobilinogen synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen." [EC:4.2.1.24, RHEA:24067] subset: gosubset_prok synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" EXACT [EC:4.2.1.24] synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" EXACT [EC:4.2.1.24] synonym: "5-levulinic acid dehydratase activity" EXACT [EC:4.2.1.24] synonym: "aminolevulinate dehydratase activity" EXACT [] synonym: "aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinate dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydrase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydratase activity" EXACT [] synonym: "delta-aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] xref: EC:4.2.1.24 xref: KEGG:R00036 xref: MetaCyc:PORPHOBILSYNTH-RXN xref: Reactome:13469 "porphobilinogen synthase activity" xref: RHEA:24067 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004656 name: procollagen-proline 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2] synonym: "collagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "hydroxylase, collagen proline activity" EXACT [EC:1.14.11.2] synonym: "peptidyl proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" EXACT [EC:1.14.11.2] synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT [] synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "proline protocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "proline, 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2] synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" EXACT [EC:1.14.11.2] synonym: "prolylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "prolylprotocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "protocollagen proline 4-hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen prolyl hydroxylase activity" EXACT [EC:1.14.11.2] xref: EC:1.14.11.2 xref: KEGG:R03219 xref: MetaCyc:1.14.11.2-RXN is_a: GO:0019798 ! procollagen-proline dioxygenase activity is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity [Term] id: GO:0004657 name: proline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] subset: gosubset_prok synonym: "L-proline dehydrogenase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:acceptor oxidoreductase activity" EXACT [EC:1.5.99.8] xref: EC:1.5.99.8 xref: MetaCyc:RXN-7181 xref: Reactome:13472 "proline dehydrogenase activity" is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0004658 name: propionyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3] subset: gosubset_prok synonym: "PCCase activity" EXACT [EC:6.4.1.3] synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.3] synonym: "propionyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.3] xref: EC:6.4.1.3 xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN xref: Reactome:13473 "propionyl-CoA carboxylase activity" is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0004659 name: prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah] subset: gosubset_prok xref: EC:2.5.1.- xref: MetaCyc:GPPSYN-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004660 name: protein farnesyltransferase activity namespace: molecular_function alt_id: GO:0018223 def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375] synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" EXACT [EC:2.5.1.58] synonym: "FTase activity" EXACT [EC:2.5.1.58] synonym: "protein-cysteine farnesyltransferase activity" EXACT [] xref: EC:2.5.1.58 xref: MetaCyc:2.5.1.58-RXN is_a: GO:0008318 ! protein prenyltransferase activity [Term] id: GO:0004661 name: protein geranylgeranyltransferase activity namespace: molecular_function alt_id: GO:0018224 def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375] synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT [] xref: EC:2.5.1.- is_a: GO:0008318 ! protein prenyltransferase activity [Term] id: GO:0004662 name: CAAX-protein geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375] synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "geranylgeranyltransferase type I activity" EXACT [] synonym: "GGTase-I activity" EXACT [] synonym: "GGTaseI activity" EXACT [] synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59] synonym: "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59] xref: EC:2.5.1.59 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity [Term] id: GO:0004663 name: Rab geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "GGTase-II activity" EXACT [] synonym: "GGTaseII activity" EXACT [] synonym: "protein geranylgeranyltransferase type II activity" EXACT [] synonym: "Rab-protein geranylgeranyltransferase activity" EXACT [] synonym: "RabGGTase activity" EXACT [] synonym: "type II protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.60] xref: EC:2.5.1.60 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity [Term] id: GO:0004664 name: prephenate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51] subset: gosubset_prok synonym: "prephenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.51] synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" EXACT [EC:4.2.1.51] xref: EC:4.2.1.51 xref: MetaCyc:PREPHENATEDEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004665 name: prephenate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH." [EC:1.3.1.13, RHEA:21643] subset: gosubset_prok synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.3.1.13] synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.13] xref: EC:1.3.1.13 xref: KEGG:R01730 xref: MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN xref: RHEA:21643 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004666 name: prostaglandin-endoperoxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1] synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.1] synonym: "(PG)H synthase activity" EXACT [EC:1.14.99.1] synonym: "fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] synonym: "PG synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin endoperoxide synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin G/H synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthetase activity" EXACT [EC:1.14.99.1] xref: EC:1.14.99.1 xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN xref: Reactome:13496 "prostaglandin-endoperoxide synthase activity" is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004667 name: prostaglandin-D synthase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10603] synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "PGD2 synthase activity" EXACT [EC:5.3.99.2] synonym: "PGH-PGD isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin D2 synthase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-H2 D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-R-prostaglandin D isomerase activity" EXACT [EC:5.3.99.2] xref: EC:5.3.99.2 xref: KEGG:R02266 xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN xref: RHEA:10603 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0004668 name: protein-arginine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3." [EC:3.5.3.15] subset: gosubset_prok synonym: "peptidylarginine deiminase activity" EXACT [EC:3.5.3.15] synonym: "protein-L-arginine iminohydrolase activity" EXACT [EC:3.5.3.15] xref: EC:3.5.3.15 xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004671 name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity namespace: molecular_function alt_id: GO:0018225 def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100] subset: gosubset_prok synonym: "farnesyl cysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesyl-protein carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesylated protein C-terminal O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylated protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylcysteine carboxylmethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein-S-isoprenylcysteine O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "S-farnesylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] xref: EC:2.1.1.100 xref: KEGG:R04496 xref: MetaCyc:2.1.1.100-RXN is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004672 name: protein kinase activity namespace: molecular_function alt_id: GO:0050222 def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "protamine kinase activity" NARROW [] xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:4030 "protein kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004673 name: protein histidine kinase activity namespace: molecular_function alt_id: GO:0008896 def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah] subset: gosubset_prok synonym: "ATP:protein-L-histidine N-phosphotransferase activity" EXACT [EC:2.7.13.3] synonym: "EnvZ" NARROW [EC:2.7.13.3] synonym: "histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine kinase activity" EXACT [] synonym: "histidine protein kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine protein kinase activity" EXACT [EC:2.7.13.3] synonym: "HK1" RELATED [EC:2.7.13.3] synonym: "HP165" RELATED [EC:2.7.13.3] synonym: "protein histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine) (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein-histidine kinase activity" EXACT [] synonym: "Sln1p" NARROW [EC:2.7.13.3] xref: EC:2.7.13.3 xref: MetaCyc:2.7.13.3-RXN is_a: GO:0004672 ! protein kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0004674 name: protein serine/threonine kinase activity namespace: molecular_function alt_id: GO:0004695 alt_id: GO:0004696 alt_id: GO:0004700 def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] subset: gosubset_prok synonym: "A-kinase activity" NARROW [EC:2.7.11.1] synonym: "AP50 kinase activity" NARROW [EC:2.7.11.1] synonym: "ATP-protein transphosphorylase activity" NARROW [EC:2.7.11.1] synonym: "ATP:protein phosphotransferase (non-specific) activity" NARROW [EC:2.7.11.1] synonym: "atypical PKC activity" NARROW [] synonym: "atypical protein kinase C activity" NARROW [] synonym: "betaIIPKC" RELATED [EC:2.7.11.1] synonym: "calcium/phospholipid-dependent protein kinase activity" NARROW [EC:2.7.11.1] synonym: "casein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "cytidine 3',5'-cyclic monophosphate-responsive protein kinase activity" NARROW [EC:2.7.11.1] synonym: "dsk1" RELATED [EC:2.7.11.1] synonym: "epsilon PKC" RELATED [EC:2.7.11.1] synonym: "galactosyltransferase-associated kinase activity" NARROW [] synonym: "glycogen synthase a kinase activity" NARROW [EC:2.7.11.1] synonym: "glycogen synthase A kinase activity" NARROW [EC:2.7.11.1] synonym: "glycogen synthase kinase 3 activity" NARROW [] synonym: "glycogen synthase kinase activity" NARROW [EC:2.7.11.1] synonym: "HIPK2" RELATED [EC:2.7.11.1] synonym: "Hpr kinase activity" NARROW [EC:2.7.11.1] synonym: "hydroxyalkyl-protein kinase activity" NARROW [EC:2.7.11.1] synonym: "M phase-specific cdc2 kinase activity" NARROW [EC:2.7.11.1] synonym: "MAPK" RELATED [EC:2.7.11.1] synonym: "mitogen-activated protein kinase activity" BROAD [EC:2.7.11.1] synonym: "mitogen-activated S6 kinase activity" NARROW [EC:2.7.11.1] synonym: "non-specific serine/threonine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "p82 kinase activity" NARROW [EC:2.7.11.1] synonym: "phosphorylase B kinase kinase activity" NARROW [EC:2.7.11.1] synonym: "phosphorylase b kinase kinase activity" BROAD [EC:2.7.11.1] synonym: "PKA" RELATED [EC:2.7.11.1] synonym: "PKC" RELATED [EC:2.7.11.1] synonym: "protein glutamyl kinase activity" NARROW [EC:2.7.11.1] synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "protein kinase A activity" BROAD [EC:2.7.11.1] synonym: "protein kinase p58 activity" NARROW [EC:2.7.11.1] synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine-threonine kinase activity" EXACT [EC:2.7.11.1] synonym: "protein-aspartyl kinase activity" RELATED [EC:2.7.11.1] synonym: "protein-cysteine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] synonym: "Prp4 protein kinase activity" NARROW [EC:2.7.11.1] synonym: "Raf kinase activity" NARROW [EC:2.7.11.1] synonym: "Raf-1" RELATED [EC:2.7.11.1] synonym: "ribosomal protein S6 kinase II activity" NARROW [EC:2.7.11.1] synonym: "ribosomal S6 protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1] synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1] synonym: "STK32" RELATED [EC:2.7.11.1] synonym: "T-antigen kinase activity" NARROW [EC:2.7.11.1] synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "twitchin kinase activity" NARROW [EC:2.7.11.1] synonym: "Wee 1-like kinase activity" NARROW [EC:2.7.11.1] synonym: "Wee-kinase activity" NARROW [EC:2.7.11.1] synonym: "WEE1Hu" RELATED [EC:2.7.11.1] xref: EC:2.7.11 xref: Reactome:4028 "protein serine/threonine kinase activity" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004675 name: transmembrane receptor protein serine/threonine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30] synonym: "activin receptor kinase activity" NARROW [EC:2.7.11.30] synonym: "ATP:receptor-protein phosphotransferase activity" EXACT [EC:2.7.11.30] synonym: "receptor protein serine/threonine kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor serine/threonine protein kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor type I serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "receptor type II serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "STK13" RELATED [EC:2.7.11.30] synonym: "TGF-beta kinase activity" NARROW [EC:2.7.11.30] xref: EC:2.7.11.- xref: MetaCyc:2.7.11.30-RXN xref: Reactome:11160 "transmembrane receptor protein serine/threonine kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0004676 name: 3-phosphoinositide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate." [GOC:mah] synonym: "PDK activity" RELATED [PMID:10075713] synonym: "phosphatidylinositol-3-phosphate protein kinase activity" EXACT [GOC:curators] xref: EC:2.7.11.- xref: Reactome:13519 "3-phosphoinositide-dependent protein kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004677 name: DNA-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA." [GOC:mah] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004679 name: AMP-activated protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [GOC:mah] synonym: "5'-AMP-activated protein kinase activity" EXACT [] synonym: "SNF1A/AMP-activated protein kinase activity" NARROW [] xref: EC:2.7.11.- xref: Reactome:13522 "AMP-activated protein kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004680 name: casein kinase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. xref: EC:2.7.11.- is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004681 name: casein kinase I activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. xref: EC:2.7.11.- is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004682 name: protein kinase CK2 activity namespace: molecular_function alt_id: GO:0008604 def: "OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase II activity" RELATED [] synonym: "casein kinase II, catalytic activity" EXACT [] synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT [] is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004683 name: calmodulin-dependent protein kinase activity namespace: molecular_function alt_id: GO:0004684 alt_id: GO:0004685 alt_id: GO:0004688 def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] subset: gosubset_prok synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17] synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/CaM-dependent kinase activity" EXACT [] synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT [] synonym: "calcium/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17] synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17] synonym: "calmodulin regulated protein kinase activity" EXACT [] synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17] synonym: "calmodulin-dependent protein kinase I activity" NARROW [] synonym: "CaM kinase activity" EXACT [EC:2.7.11.17] synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17] synonym: "CAM PKII" RELATED [EC:2.7.11.17] synonym: "CaM-regulated serine/threonine kinase activity" EXACT [EC:2.7.11.17] synonym: "CaMKI" RELATED [EC:2.7.11.17] synonym: "CaMKII" RELATED [EC:2.7.11.17] synonym: "CaMKIV" RELATED [EC:2.7.11.17] synonym: "CaMKKalpha" RELATED [EC:2.7.11.17] synonym: "CaMKKbeta" RELATED [EC:2.7.11.17] synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17] synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED [] synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED [] synonym: "STK20" RELATED [EC:2.7.11.17] xref: EC:2.7.11.17 xref: MetaCyc:2.7.11.17-RXN xref: Reactome:4026 "calmodulin-dependent protein kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004686 name: elongation factor-2 kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate." [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN] synonym: "ATP:elongation factor 2 phosphotransferase activity" EXACT [EC:2.7.11.20] synonym: "Ca/CaM-kinase III activity" EXACT [EC:2.7.11.20] synonym: "calmodulin-dependent protein kinase III activity" EXACT [EC:2.7.11.20] synonym: "CaM kinase III activity" EXACT [EC:2.7.11.20] synonym: "eEF-2 kinase activity" EXACT [] synonym: "eEF2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eEF2K" RELATED [EC:2.7.11.20] synonym: "EF2K" RELATED [EC:2.7.11.20] synonym: "elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "STK19" RELATED [EC:2.7.11.20] xref: EC:2.7.11.20 xref: MetaCyc:2.7.11.20-RXN is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0004687 name: myosin light chain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase activity" EXACT [EC:2.7.11.18] synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" EXACT [EC:2.7.11.18] synonym: "MLCK" RELATED [EC:2.7.11.18] synonym: "MLCkase activity" EXACT [EC:2.7.11.18] synonym: "myosin kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light chain protein kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating)" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating) activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin-light-chain kinase activity" EXACT [] synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18] synonym: "STK18" RELATED [EC:2.7.11.18] xref: EC:2.7.11.18 xref: MetaCyc:2.7.11.18-RXN xref: Reactome:13543 "myosin light chain kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004689 name: phosphorylase kinase activity namespace: molecular_function alt_id: GO:0008606 def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19] subset: gosubset_prok synonym: "ATP:phosphorylase-b phosphotransferase activity" EXACT [EC:2.7.11.19] synonym: "dephosphophosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "glycogen phosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "PHK" RELATED [EC:2.7.11.19] synonym: "phosphorylase b kinase activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase B kinase activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT [] synonym: "STK17" RELATED [EC:2.7.11.19] xref: EC:2.7.11.19 xref: MetaCyc:2.7.11.19-RXN xref: Reactome:13545 "phosphorylase kinase activity" is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0004690 name: cyclic nucleotide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004691 name: cAMP-dependent protein kinase activity namespace: molecular_function alt_id: GO:0008602 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11] synonym: "3',5' cAMP-dependent protein kinase activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [] synonym: "AMPK" RELATED [EC:2.7.11.11] synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [EC:2.7.11.11] synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "cyclic AMP-dependent protein kinase activity" EXACT [] synonym: "PKA" RELATED [EC:2.7.11.11] synonym: "PKA C" RELATED [EC:2.7.11.11] synonym: "protein kinase A activity" BROAD [EC:2.7.11.11] synonym: "STK22" RELATED [EC:2.7.11.11] xref: EC:2.7.11.11 xref: MetaCyc:2.7.11.11-RXN xref: Reactome:13562 "cAMP-dependent protein kinase activity" is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity [Term] id: GO:0004692 name: cGMP-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah] synonym: "3':5'-cyclic GMP-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" EXACT [EC:2.7.11.12] synonym: "cGMP-dependent protein kinase ibeta activity" EXACT [EC:2.7.11.12] synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "PKG" RELATED [EC:2.7.11.12] synonym: "PKG 1alpha" RELATED [EC:2.7.11.12] synonym: "PKG 1beta" RELATED [EC:2.7.11.12] synonym: "PKG II" RELATED [EC:2.7.11.12] synonym: "STK23" RELATED [EC:2.7.11.12] xref: EC:2.7.11.12 xref: MetaCyc:2.7.11.12-RXN xref: Reactome:13563 "cGMP-dependent protein kinase activity" is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity [Term] id: GO:0004693 name: cyclin-dependent protein kinase activity namespace: molecular_function alt_id: GO:0016537 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:rn, PMID:7877684, PMID:9841670] synonym: "ATP:cyclin phosphotransferase activity" EXACT [EC:2.7.11.22] synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22] synonym: "CDK" RELATED [EC:2.7.11.22] synonym: "CDK activity" EXACT [] synonym: "CDK, catalytic subunit activity" EXACT [] synonym: "cdk-activating kinase activity" EXACT [EC:2.7.11.22] synonym: "Cdk-activating protein kinase activity" EXACT [EC:2.7.11.22] synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22] synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22] synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22] xref: EC:2.7.11.22 xref: MetaCyc:2.7.11.22-RXN xref: Reactome:13565 "cyclin-dependent protein kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004694 name: eukaryotic translation initiation factor 2alpha kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate." [GOC:mah, InterPro:IPR015516] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004697 name: protein kinase C activity namespace: molecular_function alt_id: GO:0004701 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" EXACT [EC:2.7.11.13] synonym: "cPKC" RELATED [EC:2.7.11.13] synonym: "cPKCalpha" RELATED [EC:2.7.11.13] synonym: "cPKCbeta" RELATED [EC:2.7.11.13] synonym: "cPKCgamma" RELATED [EC:2.7.11.13] synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT [] synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT [] synonym: "nPKC" RELATED [EC:2.7.11.13] synonym: "nPKCdelta" RELATED [EC:2.7.11.13] synonym: "nPKCepsilon" RELATED [EC:2.7.11.13] synonym: "nPKCeta" RELATED [EC:2.7.11.13] synonym: "nPKCtheta" RELATED [EC:2.7.11.13] synonym: "PKC" RELATED [EC:2.7.11.13] synonym: "PKC activity" EXACT [] synonym: "Pkc1p" RELATED [EC:2.7.11.13] synonym: "PKCalpha" RELATED [EC:2.7.11.13] synonym: "PKCbeta" RELATED [EC:2.7.11.13] synonym: "PKCdelta" RELATED [EC:2.7.11.13] synonym: "PKCepsilon" RELATED [EC:2.7.11.13] synonym: "PKCgamma" RELATED [EC:2.7.11.13] synonym: "PKCzeta" RELATED [EC:2.7.11.13] synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13] synonym: "STK24" RELATED [EC:2.7.11.13] xref: EC:2.7.11.13 xref: MetaCyc:2.7.11.13-RXN xref: Reactome:13569 "protein kinase C activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004698 name: calcium-dependent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-dependent PKC activity" EXACT [] synonym: "conventional protein kinase C activity" EXACT [PMID:9601053] xref: EC:2.7.11.- xref: Reactome:13572 "calcium-dependent protein kinase C activity" is_a: GO:0004697 ! protein kinase C activity is_a: GO:0009931 ! calcium-dependent protein serine/threonine kinase activity [Term] id: GO:0004699 name: calcium-independent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-independent PKC activity" EXACT [] synonym: "novel protein kinase C activity" EXACT [PMID:9601053] is_a: GO:0004697 ! protein kinase C activity [Term] id: GO:0004702 name: receptor signaling protein serine/threonine kinase activity namespace: molecular_function def: "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] synonym: "receptor signalling protein serine/threonine kinase activity" EXACT [] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0004703 name: G-protein coupled receptor kinase activity namespace: molecular_function alt_id: GO:0004678 def: "Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate." [GOC:dph] synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" EXACT [EC:2.7.11.16] synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "G protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "GPCR kinase activity" EXACT [EC:2.7.11.16] synonym: "GPCR phosphorylating protein kinase activity" EXACT [] synonym: "GPCRK" RELATED [EC:2.7.11.16] synonym: "GRK4" RELATED [EC:2.7.11.16] synonym: "GRK5" RELATED [EC:2.7.11.16] synonym: "GRK6" RELATED [EC:2.7.11.16] synonym: "STK16" RELATED [EC:2.7.11.16] xref: EC:2.7.11.16 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004704 name: NF-kappaB-inducing kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK)." [PMID:20685151] synonym: "NIK" EXACT [] xref: EC:2.7.11.- is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity [Term] id: GO:0004705 name: JUN kinase activity namespace: molecular_function def: "Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "c-Jun N-terminal kinase activity" NARROW [] synonym: "JNK" EXACT [] synonym: "JNK3alpha1" RELATED [] synonym: "SAPK1" NARROW [] xref: EC:2.7.11.- xref: Reactome:14136 "JUN kinase activity" is_a: GO:0016909 ! SAP kinase activity [Term] id: GO:0004706 name: JUN kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf] synonym: "JNK kinase kinase activity" RELATED [] synonym: "JNKKK" EXACT [] xref: EC:2.7.11.- is_a: GO:0004709 ! MAP kinase kinase kinase activity [Term] id: GO:0004707 name: MAP kinase activity namespace: molecular_function alt_id: GO:0008338 alt_id: GO:0008339 alt_id: GO:0016908 def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" EXACT [EC:2.7.11.24] synonym: "Dp38" RELATED [EC:2.7.11.24] synonym: "ERK" RELATED [EC:2.7.11.24] synonym: "ERK1" EXACT [] synonym: "ERK2" RELATED [] synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24] synonym: "LeMPK3" RELATED [EC:2.7.11.24] synonym: "MAP kinase 1 activity" NARROW [] synonym: "MAP kinase 2 activity" NARROW [] synonym: "MAP-2 kinase activity" NARROW [EC:2.7.11.24] synonym: "MAPK" RELATED [EC:2.7.11.24] synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24] synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24] synonym: "mitogen activated kinase activity" EXACT [] synonym: "mitogen-activated protein kinase activity" EXACT [EC:2.7.11.24] synonym: "MP kinase activity" NARROW [] synonym: "Mpk2" NARROW [] synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p38" NARROW [] synonym: "p38-2" RELATED [EC:2.7.11.24] synonym: "p38delta" RELATED [EC:2.7.11.24] synonym: "p42 mitogen-activated protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p42mapk" RELATED [EC:2.7.11.24] synonym: "p44mpk" RELATED [EC:2.7.11.24] synonym: "PMK-1" RELATED [EC:2.7.11.24] synonym: "PMK-2" RELATED [EC:2.7.11.24] synonym: "PMK-3" RELATED [EC:2.7.11.24] synonym: "pp42" RELATED [EC:2.7.11.24] synonym: "pp44mapk" RELATED [EC:2.7.11.24] synonym: "SAPK2" NARROW [] synonym: "STK26" RELATED [EC:2.7.11.24] xref: EC:2.7.11.24 xref: KEGG:R00162 xref: MetaCyc:2.7.11.24-RXN xref: Reactome:4049 "MAP kinase activity" is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity [Term] id: GO:0004708 name: MAP kinase kinase activity namespace: molecular_function def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase." [ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" EXACT [EC:2.7.12.2] synonym: "ERK activator kinase activity" EXACT [] synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2] synonym: "MAP2K" RELATED [EC:2.7.12.2] synonym: "MAPKK" RELATED [EC:2.7.12.2] synonym: "MAPKK activity" EXACT [] synonym: "MAPKK1" RELATED [EC:2.7.12.2] synonym: "MEK activity" BROAD [] synonym: "MEK1" RELATED [EC:2.7.12.2] synonym: "MEK2" RELATED [EC:2.7.12.2] synonym: "mitogen-activated protein kinase kinase activity" EXACT [EC:2.7.12.2] synonym: "MKK" RELATED [EC:2.7.12.2] synonym: "MKK2" RELATED [EC:2.7.12.2] synonym: "MKK4" RELATED [EC:2.7.12.2] synonym: "MKK6" RELATED [EC:2.7.12.2] synonym: "MKK7" RELATED [EC:2.7.12.2] synonym: "STK27" RELATED [EC:2.7.12.2] xref: EC:2.7.11.- xref: MetaCyc:2.7.12.2-RXN xref: Reactome:14146 "MAP kinase kinase activity" is_a: GO:0004712 ! protein serine/threonine/tyrosine kinase activity [Term] id: GO:0004709 name: MAP kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" EXACT [EC:2.7.11.25] synonym: "cMos" RELATED [EC:2.7.11.25] synonym: "cRaf" RELATED [EC:2.7.11.25] synonym: "MAP3K" RELATED [EC:2.7.11.25] synonym: "MAPKKK activity" EXACT [EC:2.7.11.25] synonym: "MEK kinase activity" EXACT [EC:2.7.11.25] synonym: "MEKK" RELATED [EC:2.7.11.25] synonym: "MEKK1" RELATED [EC:2.7.11.25] synonym: "MEKK2" RELATED [EC:2.7.11.25] synonym: "MEKK3" RELATED [EC:2.7.11.25] synonym: "Mil/Raf" RELATED [EC:2.7.11.25] synonym: "mitogen-activated protein kinase kinase kinase activity" EXACT [EC:2.7.11.25] synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25] synonym: "MLTK" RELATED [EC:2.7.11.25] synonym: "MLTKa" RELATED [EC:2.7.11.25] synonym: "MLTKb" RELATED [EC:2.7.11.25] synonym: "REKS" RELATED [EC:2.7.11.25] synonym: "STK28" RELATED [EC:2.7.11.25] xref: EC:2.7.11.25 xref: MetaCyc:2.7.11.25-RXN xref: Reactome:14141 "MAP kinase kinase kinase activity" is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity [Term] id: GO:0004710 name: MAP/ERK kinase kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + mitogen activated protein kinase kinase = ADP + mitogen activated protein kinase kinase phosphate." [MetaCyc:2.7.11.25-RXN] synonym: "MEKK activity" EXACT [] xref: EC:2.7.11.- is_a: GO:0004709 ! MAP kinase kinase kinase activity [Term] id: GO:0004711 name: ribosomal protein S6 kinase activity namespace: molecular_function def: "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004712 name: protein serine/threonine/tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah] subset: gosubset_prok synonym: "ADK1" RELATED [EC:2.7.12.1] synonym: "Arabidopsis dual specificity kinase 1 activity" NARROW [EC:2.7.12.1] synonym: "ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity" EXACT [EC:2.7.12.1] synonym: "CLK1" RELATED [EC:2.7.12.1] synonym: "dDYRK2" RELATED [EC:2.7.12.1] synonym: "dual-specificity kinase activity" BROAD [EC:2.7.12.1] synonym: "dual-specificity protein kinase" BROAD [] synonym: "Mps1p" RELATED [EC:2.7.12.1] synonym: "protein threonine/tyrosine kinase activity" NARROW [] xref: EC:2.7.112.1 xref: Reactome:14147 "protein serine/threonine/tyrosine kinase activity" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004713 name: protein tyrosine kinase activity namespace: molecular_function alt_id: GO:0004718 def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] subset: gosubset_prok synonym: "JAK" NARROW [] synonym: "Janus kinase activity" NARROW [] synonym: "protein-tyrosine kinase activity" EXACT [] xref: EC:2.7.10 xref: Reactome:11065 "protein tyrosine kinase activity" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004714 name: transmembrane receptor protein tyrosine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] subset: gosubset_prok synonym: "anaplastic lymphoma kinase activity" NARROW [EC:2.7.10.1] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity" EXACT [EC:2.7.10.1] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.1] synonym: "Drosophila Eph kinase activity" NARROW [EC:2.7.10.1] synonym: "ephrin-B3 receptor tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "insulin receptor protein-tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "neurite outgrowth regulating kinase activity" NARROW [EC:2.7.10.1] synonym: "neurotrophin TRK receptor activity" RELATED [] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "neurotrophin TRKC receptor activity" RELATED [] synonym: "novel oncogene with kinase-domain activity" NARROW [EC:2.7.10.1] synonym: "receptor protein tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "receptor protein-tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "sevenless receptor activity" RELATED [] xref: EC:2.7.10.1 xref: MetaCyc:2.7.10.1-RXN xref: Reactome:11064 "transmembrane receptor protein tyrosine kinase activity" is_a: GO:0004713 ! protein tyrosine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0004715 name: non-membrane spanning protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [EC:2.7.10.2] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2] synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2] synonym: "non-specific protein-tyrosine kinase activity" EXACT [EC:2.7.10.2] synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2] xref: EC:2.7.10.2 xref: MetaCyc:2.7.10.2-RXN xref: Reactome:14162 "non-membrane spanning protein tyrosine kinase activity" is_a: GO:0004713 ! protein tyrosine kinase activity [Term] id: GO:0004716 name: receptor signaling protein tyrosine kinase activity namespace: molecular_function def: "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2] synonym: "receptor signalling protein tyrosine kinase activity" EXACT [] xref: EC:2.7.10.- is_a: GO:0004713 ! protein tyrosine kinase activity is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0004717 name: focal adhesion kinase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function. synonym: "FAK" EXACT [] is_obsolete: true replaced_by: GO:0004713 [Term] id: GO:0004719 name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] subset: gosubset_prok synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein (D-aspartate) methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein D-aspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein O-methyltransferase (L-isoaspartate)" EXACT [EC:2.1.1.77] synonym: "protein-beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] xref: EC:2.1.1.77 xref: MetaCyc:2.1.1.77-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0004720 name: protein-lysine 6-oxidase activity namespace: molecular_function alt_id: GO:0018056 def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide." [EC:1.4.3.13] synonym: "lysyl oxidase activity" EXACT [EC:1.4.3.13] synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" EXACT [EC:1.4.3.13] xref: EC:1.4.3.13 xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0004721 name: phosphoprotein phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16] synonym: "protein phosphatase activity" EXACT [] synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16] xref: EC:3.1.3.16 xref: MetaCyc:3.1.3.16-RXN xref: Reactome:1887 "phosphoprotein phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004722 name: protein serine/threonine phosphatase activity namespace: molecular_function alt_id: GO:0000158 alt_id: GO:0000163 alt_id: GO:0008598 alt_id: GO:0008600 alt_id: GO:0015071 alt_id: GO:0030357 alt_id: GO:0030358 alt_id: GO:0030360 alt_id: GO:0030361 def: "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf] subset: gosubset_prok synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16] synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "calcineurin" NARROW [] synonym: "casein phosphatase" NARROW [EC:3.1.3.16] synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphatase 2A" NARROW [EC:3.1.3.16] synonym: "phosphatase 2B" NARROW [EC:3.1.3.16] synonym: "phosphatase C-II" NARROW [EC:3.1.3.16] synonym: "phosphatase H-II" NARROW [EC:3.1.3.16] synonym: "phosphatase I" NARROW [EC:3.1.3.16] synonym: "phosphatase IB" NARROW [EC:3.1.3.16] synonym: "phosphatase II" NARROW [EC:3.1.3.16] synonym: "phosphatase III" NARROW [EC:3.1.3.16] synonym: "phosphatase IV" NARROW [EC:3.1.3.16] synonym: "phosphatase SP" NARROW [EC:3.1.3.16] synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16] synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16] synonym: "protein D phosphatase" NARROW [EC:3.1.3.16] synonym: "protein phosphatase type 1 activity" NARROW [] synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2A activity" NARROW [] synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2B activity" NARROW [] synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2C activity" NARROW [] synonym: "protein phosphatase type 4 activity" NARROW [] synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase X" NARROW [] synonym: "serine/threonine specific protein phosphatase activity" EXACT [] xref: Reactome:14173 "protein serine/threonine phosphatase activity" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004723 name: calcium-dependent protein serine/threonine phosphatase activity namespace: molecular_function alt_id: GO:0008596 def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [EC:3.1.3.16, GOC:mah] synonym: "calcineurin" NARROW [] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT [] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0004724 name: magnesium-dependent protein serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium." [EC:3.1.3.16] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0004725 name: protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] subset: gosubset_prok synonym: "[phosphotyrosine]protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine histone phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PPT-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.48] synonym: "PTP-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PTPase activity" EXACT [EC:3.1.3.48] synonym: "tyrosine O-phosphate phosphatase activity" EXACT [EC:3.1.3.48] synonym: "tyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] xref: EC:3.1.3.48 xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN xref: Reactome:11061 "protein tyrosine phosphatase activity" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004726 name: non-membrane spanning protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48] subset: gosubset_prok xref: Reactome:14178 "non-membrane spanning protein tyrosine phosphatase activity" is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0004727 name: prenylated protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0004728 name: receptor signaling protein tyrosine phosphatase activity namespace: molecular_function def: "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT [] is_a: GO:0004725 ! protein tyrosine phosphatase activity is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0004729 name: oxygen-dependent protoporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX." [EC:1.3.3.4, RHEA:25579] subset: gosubset_prok synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" EXACT [EC:1.3.3.4] xref: EC:1.3.3.4 xref: KEGG:R03222 xref: MetaCyc:PROTOPORGENOXI-RXN xref: Reactome:14184 "oxygen-dependent protoporphyrinogen oxidase activity" xref: RHEA:25579 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor is_a: GO:0070818 ! protoporphyrinogen oxidase activity [Term] id: GO:0004730 name: pseudouridylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate." [EC:4.2.1.70, RHEA:18340] comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine. subset: gosubset_prok synonym: "5-ribosyluracil 5-phosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridine monophosphate synthase activity" EXACT [] synonym: "pseudouridine monophosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridylate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridylic acid synthetase activity" EXACT [EC:4.2.1.70] synonym: "psiUMP synthetase activity" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" EXACT [EC:4.2.1.70] synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70] xref: EC:4.2.1.70 xref: KEGG:R01055 xref: MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN xref: RHEA:18340 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004731 name: purine-nucleoside phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1] subset: gosubset_prok synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1] synonym: "inosine-guanosine phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "PNPase activity" EXACT [EC:2.4.2.1] synonym: "PUNPI" RELATED [EC:2.4.2.1] synonym: "PUNPII" RELATED [EC:2.4.2.1] synonym: "purine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine deoxyribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine nucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine ribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine-nucleoside:phosphate ribosyltransferase activity" EXACT [EC:2.4.2.1] xref: EC:2.4.2.1 xref: MetaCyc:PNP-RXN xref: Reactome:14201 "purine-nucleoside phosphorylase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004732 name: pyridoxal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide." [EC:1.2.3.8] synonym: "pyridoxal:oxygen 4-oxidoreductase activity" EXACT [EC:1.2.3.8] xref: EC:1.2.3.8 xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0004733 name: pyridoxamine-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5] subset: gosubset_prok synonym: "PdxH" RELATED [EC:1.4.3.5] synonym: "PMP oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxal 5'-phosphate synthase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] xref: EC:1.4.3.5 xref: MetaCyc:PMPOXI-RXN xref: Reactome:14203 "pyridoxamine-phosphate oxidase activity" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0004734 name: pyrimidodiazepine synthase activity namespace: molecular_function def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1] synonym: "PDA synthase activity" EXACT [EC:1.5.4.1] synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1] xref: EC:1.5.4.1 xref: MetaCyc:1.5.4.1-RXN is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor [Term] id: GO:0004735 name: pyrroline-5-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2] subset: gosubset_prok synonym: "1-pyrroline-5-carboxylate reductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline oxidase activity" EXACT [EC:1.5.1.2] synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [EC:1.5.1.2] synonym: "P5CR activity" EXACT [EC:1.5.1.2] xref: EC:1.5.1.2 xref: MetaCyc:PYRROLINECARBREDUCT-RXN xref: Reactome:14208 "pyrroline-5-carboxylate reductase activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004736 name: pyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847] subset: gosubset_prok synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.1] synonym: "pyruvic carboxylase activity" EXACT [EC:6.4.1.1] xref: EC:6.4.1.1 xref: KEGG:R00344 xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN xref: Reactome:14209 "pyruvate carboxylase activity" xref: RHEA:20847 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0004737 name: pyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1] subset: gosubset_prok synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" EXACT [EC:4.1.1.1] synonym: "2-oxo-acid carboxy-lyase activity" EXACT [EC:4.1.1.1] synonym: "alpha-carboxylase activity" EXACT [EC:4.1.1.1] synonym: "alpha-ketoacid carboxylase activity" EXACT [EC:4.1.1.1] synonym: "pyruvic decarboxylase activity" EXACT [EC:4.1.1.1] xref: EC:4.1.1.1 xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004738 name: pyruvate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716020094] subset: gosubset_prok synonym: "pyruvic acid dehydrogenase activity" EXACT [EC:1.2.4.1] synonym: "pyruvic dehydrogenase activity" EXACT [EC:1.2.4.1] xref: MetaCyc:PYRUVOXID-RXN xref: MetaCyc:RXN0-1134 xref: Reactome:1965 "pyruvate dehydrogenase activity" is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0004739 name: pyruvate dehydrogenase (acetyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1] subset: gosubset_prok synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1] synonym: "PDH" RELATED [EC:1.2.4.1] synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT [] synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1] synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1] synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1] xref: EC:1.2.4.1 is_a: GO:0004738 ! pyruvate dehydrogenase activity is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0004740 name: pyruvate dehydrogenase (acetyl-transferring) kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2] synonym: "[pyruvate dehydrogenase (lipoamide)] kinase activity" EXACT [] synonym: "ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.2] synonym: "PDH kinase activity" EXACT [EC:2.7.11.2] synonym: "PDHK" RELATED [EC:2.7.11.2] synonym: "PDK" RELATED [EC:2.7.11.2] synonym: "PDK1" RELATED [EC:2.7.11.2] synonym: "PDK2" RELATED [EC:2.7.11.2] synonym: "PDK3" RELATED [EC:2.7.11.2] synonym: "PDK4" RELATED [EC:2.7.11.2] synonym: "pyruvate dehydrogenase (lipoamide) kinase activity" EXACT [] synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activator protein activity" NARROW [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activity" EXACT [EC:2.7.11.2] synonym: "STK1" RELATED [EC:2.7.11.2] xref: EC:2.7.11.2 xref: MetaCyc:2.7.11.2-RXN xref: Reactome:14233 "pyruvate dehydrogenase (acetyl-transferring) kinase activity" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004741 name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity namespace: molecular_function alt_id: GO:0019906 def: "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43] synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT [] synonym: "phosphopyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT [] synonym: "pyruvate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] xref: EC:3.1.3.43 xref: MetaCyc:3.1.3.43-RXN xref: Reactome:14236 "[pyruvate dehydrogenase (lipoamide)] phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004742 name: dihydrolipoyllysine-residue acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12] subset: gosubset_prok synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT [] synonym: "dihydrolipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoyl acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acid acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoylacetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12] synonym: "transacetylase X activity" NARROW [EC:2.3.1.12] xref: EC:2.3.1.12 is_a: GO:0016418 ! S-acetyltransferase activity is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity [Term] id: GO:0004743 name: pyruvate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40] subset: gosubset_prok synonym: "ATP:pyruvate 2-O-phosphotransferase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40] xref: EC:2.7.1.40 xref: MetaCyc:PEPDEPHOS-RXN xref: Reactome:14240 "pyruvate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004744 name: retinal isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [EC:5.2.1.3, RHEA:24127] synonym: "all-trans-retinal 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.3] synonym: "retinene isomerase activity" RELATED [EC:5.2.1.3] synonym: "retinoid isomerase activity" BROAD [EC:5.2.1.3] xref: EC:5.2.1.3 xref: KEGG:R02126 xref: MetaCyc:RETINAL-ISOMERASE-RXN xref: RHEA:24127 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0004745 name: retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105] subset: gosubset_prok synonym: "all-trans retinol dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "MDR" RELATED [EC:1.1.1.105] synonym: "microsomal retinol dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "retinene reductase activity" BROAD [EC:1.1.1.105] synonym: "retinol (vitamin A1) dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "retinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.105] xref: EC:1.1.1.105 xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004746 name: riboflavin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin." [EC:2.5.1.9, RHEA:20775] subset: gosubset_prok synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" EXACT [EC:2.5.1.9] synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "lumazine synthase activity" BROAD [BRENDA:2.5.1.9] synonym: "riboflavin synthetase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthetase activity" EXACT [EC:2.5.1.9] synonym: "vitamin B2 synthase activity" EXACT [] xref: EC:2.5.1.9 xref: KEGG:R00066 xref: MetaCyc:RIBOFLAVIN-SYN-RXN xref: RHEA:20775 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004747 name: ribokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15] subset: gosubset_prok synonym: "ATP:D-ribose 5-phosphotransferase activity" EXACT [EC:2.7.1.15] synonym: "D-ribokinase activity" EXACT [EC:2.7.1.15] synonym: "deoxyribokinase activity" EXACT [EC:2.7.1.15] synonym: "ribokinase (phosphorylating)" EXACT [EC:2.7.1.15] xref: EC:2.7.1.15 xref: MetaCyc:RIBOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004748 name: ribonucleoside-diphosphate reductase activity namespace: molecular_function alt_id: GO:0016959 alt_id: GO:0016960 alt_id: GO:0016961 def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1] subset: gosubset_prok synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" EXACT [] synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" EXACT [] synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" EXACT [] synonym: "class I ribonucleotide reductase activity" EXACT [] synonym: "class II ribonucleoside-diphosphate reductase activity" EXACT [] synonym: "class II ribonucleotide reductase activity" EXACT [] synonym: "class III ribonucleotide reductase activity" EXACT [] synonym: "nucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED [] synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "ribonucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "ribonucleotide diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.1] synonym: "RNR" EXACT [] xref: EC:1.17.4.1 xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN xref: Reactome:4421 "ribonucleoside-diphosphate reductase activity" is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [Term] id: GO:0004749 name: ribose phosphate diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612] subset: gosubset_prok synonym: "5-phosphoribose pyrophosphorylase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl-diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "PP-ribose P synthetase activity" EXACT [EC:2.7.6.1] synonym: "PPRibP synthetase activity" EXACT [EC:2.7.6.1] synonym: "PRPP synthetase activity" EXACT [EC:2.7.6.1] synonym: "pyrophosphoribosylphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ribophosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-5-phosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate diphosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate pyrophosphokinase activity" EXACT [] xref: EC:2.7.6.1 xref: KEGG:R01049 xref: MetaCyc:PRPPSYN-RXN xref: MetaCyc:PWY0-662 xref: Reactome:14245 "ribose phosphate diphosphokinase activity" xref: RHEA:15612 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0004750 name: ribulose-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1, RHEA:13680] subset: gosubset_prok synonym: "D-ribulose 5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose phosphate-3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-P 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-xylulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate isomerase activity" EXACT [EC:5.1.3.1] synonym: "pentose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoribulose epimerase activity" EXACT [EC:5.1.3.1] synonym: "ribulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "xylulose phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] xref: EC:5.1.3.1 xref: KEGG:R01529 xref: MetaCyc:RIBULP3EPIM-RXN xref: Reactome:14262 "ribulose-phosphate 3-epimerase activity" xref: RHEA:13680 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0004751 name: ribose-5-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6, RHEA:14660] subset: gosubset_prok synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6] synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6] synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6] xref: EC:5.3.1.6 xref: KEGG:R01056 xref: MetaCyc:RIB5PISOM-RXN xref: Reactome:14263 "ribose-5-phosphate isomerase activity" xref: RHEA:14660 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004753 name: saccharopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah] subset: gosubset_prok synonym: "lysine-2-oxoglutarate reductase activity" EXACT [EC:1.5.1.-] synonym: "lysine-ketoglutarate reductase activity" EXACT [EC:1.5.1.-] xref: EC:1.5.1.- is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004754 name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH." [EC:1.5.1.7, RHEA:12443] subset: gosubset_prok synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" EXACT [EC:1.5.1.7] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" EXACT [EC:1.5.1.7] synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] xref: EC:1.5.1.7 xref: KEGG:R00715 xref: MetaCyc:1.5.1.7-RXN xref: RHEA:12443 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0004755 name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH." [EC:1.5.1.10, RHEA:10023] subset: gosubset_prok synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "aminoadipate semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamic reductase activity" EXACT [EC:1.5.1.10] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" EXACT [EC:1.5.1.10] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" EXACT [EC:1.5.1.10] synonym: "saccharopine reductase activity" EXACT [EC:1.5.1.10] xref: EC:1.5.1.10 xref: KEGG:R02315 xref: MetaCyc:RXN3O-127 xref: RHEA:10023 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0004756 name: selenide, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate." [EC:2.7.9.3, RHEA:18740] subset: gosubset_prok synonym: "ATP:selenide, water phosphotransferase activity" EXACT [EC:2.7.9.3] synonym: "selenide,water dikinase activity" EXACT [EC:2.7.9.3] synonym: "selenium donor protein activity" EXACT [EC:2.7.9.3] synonym: "selenophosphate synthase activity" EXACT [] synonym: "selenophosphate synthetase activity" EXACT [EC:2.7.9.3] xref: EC:2.7.9.3 xref: KEGG:R03595 xref: MetaCyc:2.7.9.3-RXN xref: RHEA:18740 xref: UM-BBD_reactionID:r0833 is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0004757 name: sepiapterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153] subset: gosubset_prok synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.153] xref: EC:1.1.1.153 xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004758 name: serine C-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA." [EC:2.3.1.50, RHEA:14764] synonym: "3-oxosphinganine synthetase activity" EXACT [EC:2.3.1.50] synonym: "acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [EC:2.3.1.50] synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.50] synonym: "serine palmitoyltransferase" BROAD [] synonym: "SPT" RELATED [EC:2.3.1.50] xref: EC:2.3.1.50 xref: KEGG:R01281 xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN xref: Reactome:14271 "serine C-palmitoyltransferase activity" xref: RHEA:14764 is_a: GO:0016454 ! C-palmitoyltransferase activity [Term] id: GO:0004760 name: serine-pyruvate transaminase activity namespace: molecular_function alt_id: GO:0004761 alt_id: GO:0004762 alt_id: GO:0004763 def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51, RHEA:22855] subset: gosubset_prok synonym: "hydroxypyruvate:L-alanine transaminase activity" EXACT [EC:2.6.1.51] synonym: "L-serine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase activity" EXACT [] synonym: "serine-pyruvate aminotransferase, type 1" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2A" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B" NARROW [] synonym: "SPT" RELATED [EC:2.6.1.51] xref: EC:2.6.1.51 xref: KEGG:R00585 xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN xref: RHEA:22855 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004764 name: shikimate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+." [EC:1.1.1.25] subset: gosubset_prok synonym: "5-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25] synonym: "5-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] synonym: "dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] synonym: "DHS reductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate oxidoreductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate:NADP(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate:NADP(+) oxidoreductase activity" EXACT [EC:1.1.1.25] xref: EC:1.1.1.25 xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN xref: Reactome:14294 "shikimate 5-dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004765 name: shikimate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+)." [EC:2.7.1.71, RHEA:13124] subset: gosubset_prok synonym: "ATP:shikimate 3-phosphotransferase activity" EXACT [EC:2.7.1.71] synonym: "shikimate kinase (phosphorylating)" EXACT [EC:2.7.1.71] synonym: "shikimate kinase II" RELATED [EC:2.7.1.71] xref: EC:2.7.1.71 xref: KEGG:R02412 xref: MetaCyc:SHIKIMATE-KINASE-RXN xref: Reactome:14295 "shikimate kinase activity" xref: RHEA:13124 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004766 name: spermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16] subset: gosubset_prok synonym: "aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "putrescine aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "SpeE" RELATED [EC:2.5.1.16] synonym: "spermidine synthetase activity" EXACT [EC:2.5.1.16] xref: EC:2.5.1.16 xref: MetaCyc:SPERMIDINESYN-RXN xref: Reactome:14296 "spermidine synthase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004767 name: sphingomyelin phosphodiesterase activity namespace: molecular_function alt_id: GO:0030230 alt_id: GO:0030231 def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] subset: gosubset_prok synonym: "acid sphingomyelin phosphodiesterase" NARROW [] synonym: "acid sphingomyelinase activity" NARROW [EC:3.1.4.12] synonym: "neutral sphingomyelin phosphodiesterase" NARROW [] synonym: "neutral sphingomyelinase activity" NARROW [EC:3.1.4.12] synonym: "sphingomyelin cholinephosphohydrolase activity" EXACT [EC:3.1.4.12] synonym: "sphingomyelinase activity" EXACT [] xref: EC:3.1.4.12 xref: KEGG:R02541 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN xref: Reactome:14297 "sphingomyelin phosphodiesterase activity" xref: RHEA:19256 is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004768 name: stearoyl-CoA 9-desaturase activity namespace: molecular_function alt_id: GO:0016214 alt_id: GO:0043735 def: "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] comment: Note that this function was formerly EC:1.14.99.5. subset: gosubset_prok synonym: "acyl-CoA desaturase activity" EXACT [EC:1.14.19.1] synonym: "delta(9)-desaturase activity" EXACT [EC:1.14.19.1] synonym: "delta-9 acyl-phospholipid desaturase activity" RELATED [] synonym: "delta9-desaturase activity" EXACT [EC:1.14.19.1] synonym: "fatty acid desaturase activity" EXACT [EC:1.14.19.1] synonym: "stearoyl-CoA desaturase activity" EXACT [] synonym: "stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.1] synonym: "stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)" EXACT [EC:1.14.19.1] xref: EC:1.14.19.1 xref: MetaCyc:1.14.19.1-RXN is_a: GO:0016215 ! CoA desaturase activity [Term] id: GO:0004769 name: steroid delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1] subset: gosubset_prok synonym: "3-oxosteroid delta5-delta4-isomerase activity" EXACT [EC:5.3.3.1] synonym: "3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5(or delta4)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "hydroxysteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "steroid D-isomerase activity" EXACT [] synonym: "steroid isomerase activity" EXACT [EC:5.3.3.1] xref: EC:5.3.3.1 xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN xref: Reactome:14301 "steroid delta-isomerase activity" is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004771 name: sterol esterase activity namespace: molecular_function def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] synonym: "acylcholesterol lipase activity" EXACT [EC:3.1.1.13] synonym: "cholesterase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13] synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13] synonym: "cholesteryl ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl ester synthase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl esterase activity" EXACT [EC:3.1.1.13] synonym: "sterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "steryl-ester acylhydrolase activity" EXACT [EC:3.1.1.13] synonym: "triterpenol esterase activity" EXACT [EC:3.1.1.13] xref: EC:3.1.1.13 xref: MetaCyc:STEROL-ESTERASE-RXN xref: Reactome:14316 "sterol esterase activity" is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004772 name: sterol O-acyltransferase activity namespace: molecular_function alt_id: GO:0017066 def: "Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester." [EC:2.3.1.26, GOC:mah] synonym: "sterol-ester synthase activity" EXACT [EC:2.3.1.26] synonym: "sterol-ester synthetase activity" EXACT [EC:2.3.1.26] xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004773 name: steryl-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate." [EC:3.1.6.2] synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "arylsulfatase C activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "phenolic steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "pregnenolone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid 3-sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "sterol sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulphatase activity" EXACT [] xref: EC:3.1.6.2 xref: MetaCyc:STERYL-SULFATASE-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004774 name: succinate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [EC:6.2.1.-, GOC:ai] subset: gosubset_prok xref: EC:6.2.1.- is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0004775 name: succinate-CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5] subset: gosubset_prok synonym: "A-SCS" RELATED [EC:6.2.1.5] synonym: "A-STK (adenin nucleotide-linked succinate thiokinase)" RELATED [EC:6.2.1.5] synonym: "succinate thiokinase activity" EXACT [EC:6.2.1.5] synonym: "succinate:CoA ligase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinic thiokinase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase activity" EXACT [EC:6.2.1.5] xref: EC:6.2.1.5 xref: KEGG:R00405 xref: MetaCyc:SUCCCOASYN-RXN xref: Reactome:14321 "succinate-CoA ligase (ADP-forming) activity" xref: RHEA:17664 is_a: GO:0004774 ! succinate-CoA ligase activity [Term] id: GO:0004776 name: succinate-CoA ligase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4] subset: gosubset_prok synonym: "G-STK" RELATED [EC:6.2.1.4] synonym: "P-enzyme" RELATED [EC:6.2.1.4] synonym: "SCS" RELATED [EC:6.2.1.4] synonym: "succinate-phosphorylating enzyme" RELATED [EC:6.2.1.4] synonym: "succinate:CoA ligase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinic thiokinase" BROAD [EC:6.2.1.4] synonym: "succinyl CoA synthetase activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] xref: EC:6.2.1.4 xref: KEGG:R00432 xref: MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN xref: Reactome:14322 "succinate-CoA ligase (GDP-forming) activity" xref: RHEA:22123 is_a: GO:0004774 ! succinate-CoA ligase activity [Term] id: GO:0004777 name: succinate-semialdehyde dehydrogenase activity namespace: molecular_function alt_id: GO:0008952 def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24] subset: gosubset_prok synonym: "succinate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] xref: EC:1.2.1.24 xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN xref: Reactome:14323 "succinate-semialdehyde dehydrogenase activity" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004778 name: succinyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate." [EC:3.1.2.3, RHEA:11519] synonym: "succinyl coenzyme A deacylase activity" EXACT [EC:3.1.2.3] synonym: "succinyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.3] synonym: "succinyl-CoA acylase activity" EXACT [EC:3.1.2.3] xref: EC:3.1.2.3 xref: KEGG:R00407 xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN xref: RHEA:11519 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0004779 name: sulfate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN] subset: gosubset_prok synonym: "sulphate adenylyltransferase activity" EXACT [] xref: EC:2.7.7.- is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004780 name: sulfate adenylyltransferase (ADP) activity namespace: molecular_function def: "Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate." [EC:2.7.7.5, RHEA:16532] synonym: "adenosine diphosphate sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP-sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" EXACT [EC:2.7.7.5] synonym: "sulphate adenylyltransferase (ADP) activity" EXACT [] xref: EC:2.7.7.5 xref: KEGG:R00530 xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN xref: RHEA:16532 is_a: GO:0004779 ! sulfate adenylyltransferase activity [Term] id: GO:0004781 name: sulfate adenylyltransferase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4] subset: gosubset_prok synonym: "adenosine-5'-triphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenosinetriphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenylylsulfate pyrophosphorylase activity" EXACT [EC:2.7.7.4] synonym: "ATP sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP-sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate adenylate transferase activity" EXACT [EC:2.7.7.4] synonym: "sulfurylase activity" RELATED [EC:2.7.7.4] synonym: "sulphate adenylyltransferase (ATP) activity" EXACT [] xref: EC:2.7.7.4 xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN xref: Reactome:14341 "sulfate adenylyltransferase (ATP) activity" is_a: GO:0004779 ! sulfate adenylyltransferase activity [Term] id: GO:0004782 name: sulfinoalanine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" EXACT [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase activity" EXACT [EC:4.1.1.29] synonym: "CADCase/CSADCase activity" EXACT [EC:4.1.1.29] synonym: "CSAD" RELATED [EC:4.1.1.29] synonym: "CSADCase activity" EXACT [EC:4.1.1.29] synonym: "cysteic decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteine-sulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "L-cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulphinoalanine decarboxylase activity" EXACT [] xref: EC:4.1.1.29 xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004783 name: sulfite reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+." [EC:1.8.1.2] subset: gosubset_prok synonym: "H2S-NADP oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-dependent sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH:sulfite reductase flavoprotein" RELATED [] synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.8.1.2] synonym: "sulphite reductase (NADPH) activity" EXACT [] xref: EC:1.8.1.2 xref: MetaCyc:SULFITE-REDUCT-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0004784 name: superoxide dismutase activity namespace: molecular_function alt_id: GO:0004785 alt_id: GO:0008382 alt_id: GO:0008383 alt_id: GO:0016954 def: "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1] subset: gosubset_prok synonym: "copper, zinc superoxide dismutase activity" NARROW [] synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1] synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "cuprein" RELATED [EC:1.15.1.1] synonym: "cytocuprein" RELATED [EC:1.15.1.1] synonym: "erythrocuprein" RELATED [EC:1.15.1.1] synonym: "Fe-SOD" RELATED [EC:1.15.1.1] synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "hemocuprein" RELATED [EC:1.15.1.1] synonym: "hepatocuprein" RELATED [EC:1.15.1.1] synonym: "iron superoxide dismutase activity" NARROW [] synonym: "iron superoxide oxidoreductase" RELATED [] synonym: "manganese superoxide dismutase activity" NARROW [] synonym: "manganese superoxide oxidoreductase" RELATED [] synonym: "Mn, Fe superoxide dismutase" NARROW [] synonym: "Mn-SOD" RELATED [EC:1.15.1.1] synonym: "nickel superoxide dismutase activity" NARROW [] synonym: "nickel superoxide oxidoreductase" RELATED [] synonym: "SOD" RELATED [EC:1.15.1.1] synonym: "SOD-1" RELATED [EC:1.15.1.1] synonym: "SOD-2" RELATED [EC:1.15.1.1] synonym: "SOD-3" RELATED [EC:1.15.1.1] synonym: "SOD-4" RELATED [EC:1.15.1.1] synonym: "SODF" RELATED [EC:1.15.1.1] synonym: "SODS" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1] synonym: "superoxide:superoxide oxidoreductase activity" EXACT [] synonym: "zinc superoxide oxidoreductase" RELATED [] xref: EC:1.15.1.1 xref: MetaCyc:SUPEROX-DISMUT-RXN is_a: GO:0016209 ! antioxidant activity is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0004786 name: Mn, Fe superoxide dismutase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the function is covered by an existing term. is_obsolete: true consider: GO:0004784 [Term] id: GO:0004787 name: thiamine-pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: TDP + H2O = TMP + phosphate." [EC:3.6.1.-, GOC:ai] synonym: "thiamin pyrophosphatase activity" EXACT [] synonym: "thiamin-pyrophosphatase activity" EXACT [GOC:curators] synonym: "thiamine pyrophosphatase activity" EXACT [] synonym: "thiaminpyrophosphatase activity" EXACT [EC:3.6.1.6] synonym: "TPPase activity" EXACT [] xref: EC:3.6.1.- is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0004788 name: thiamine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate." [EC:2.7.6.2] subset: gosubset_prok synonym: "ATP:thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "ATP:thiamine diphosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin diphosphokinase activity" EXACT [GOC:curators] synonym: "thiamin pyrophosphokinase activity" EXACT [] synonym: "thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin:ATP pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamine pyrophosphokinase activity" EXACT [] synonym: "thiaminokinase activity" EXACT [EC:2.7.6.2] synonym: "TPTase activity" EXACT [EC:2.7.6.2] xref: EC:2.7.6.2 xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN xref: Reactome:14348 "thiamine diphosphokinase activity" is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0004789 name: thiamine-phosphate diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate." [EC:2.5.1.3, RHEA:22331] subset: gosubset_prok synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.3] synonym: "thiamin-phosphate diphosphorylase activity" EXACT [GOC:curators] synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine monophosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine phosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine-phosphate synthase activity" EXACT [EC:2.5.1.3] synonym: "TMP diphosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP-PPase activity" EXACT [EC:2.5.1.3] xref: EC:2.5.1.3 xref: KEGG:R03223 xref: MetaCyc:THI-P-SYN-RXN xref: RHEA:22331 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004790 name: thioether S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96, RHEA:19616] synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "thioether methyltransferase activity" EXACT [EC:2.1.1.96] xref: EC:2.1.1.96 xref: KEGG:R02572 xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN xref: RHEA:19616 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004791 name: thioredoxin-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [EC:1.8.1.9, RHEA:20348] subset: gosubset_prok synonym: "NADP--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "thioredoxin disulfide reductase activity" EXACT [] synonym: "thioredoxin reductase (NADPH) activity" EXACT [] synonym: "thioredoxin-disulphide reductase activity" EXACT [] synonym: "thioredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.9] xref: EC:1.8.1.9 xref: KEGG:R02016 xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN xref: Reactome:14367 "thioredoxin-disulfide reductase activity" xref: RHEA:20348 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0004792 name: thiosulfate sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884] subset: gosubset_prok synonym: "rhodanase activity" EXACT [EC:2.8.1.1] synonym: "rhodanese activity" RELATED [EC:2.8.1.1] synonym: "thiosulfate cyanide transsulfurase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate thiotransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulphate sulphurtransferase activity" EXACT [] xref: EC:2.8.1.1 xref: KEGG:R01931 xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN xref: RHEA:16884 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0004793 name: threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5] subset: gosubset_prok synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.5] synonym: "L-threonine acetaldehyde-lyase activity" EXACT [EC:4.1.2.5] synonym: "L-threonine aldolase activity" EXACT [] xref: EC:4.1.2.5 xref: MetaCyc:THREONINE-ALDOLASE-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004794 name: L-threonine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19] comment: Note that this function was formerly EC:4.2.1.16. subset: gosubset_prok synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19] synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19] synonym: "L-threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine dehydratase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.19] synonym: "serine deaminase activity" RELATED [EC:4.3.1.19] synonym: "threonine ammonia-lyase activity" EXACT [] synonym: "threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydrase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydratase activity" EXACT [] xref: EC:4.3.1.19 xref: MetaCyc:THREDEHYD-RXN xref: UM-BBD_reactionID:r0433 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0004795 name: threonine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1] subset: gosubset_prok synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" EXACT [EC:4.2.3.1] synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" EXACT [EC:4.2.3.1] synonym: "threonine synthetase activity" EXACT [EC:4.2.3.1] xref: EC:4.2.3.1 xref: MetaCyc:THRESYN-RXN is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0004796 name: thromboxane-A synthase activity namespace: molecular_function alt_id: GO:0008400 def: "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" EXACT [EC:5.3.99.5] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" EXACT [EC:5.3.99.5] synonym: "cytochrome P450 CYP5" NARROW [] synonym: "thromboxane synthase activity" EXACT [EC:5.3.99.5] synonym: "thromboxane synthetase activity" EXACT [EC:5.3.99.5] xref: EC:5.3.99.5 xref: KEGG:R02268 xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN xref: Reactome:14373 "thromboxane-A synthase activity" xref: RHEA:17140 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0004797 name: thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21] subset: gosubset_prok synonym: "2'-deoxythymidine kinase activity" EXACT [EC:2.7.1.21] synonym: "ATP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.21] synonym: "deoxythymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] synonym: "thymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] xref: EC:2.7.1.21 xref: MetaCyc:THYKI-RXN is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004798 name: thymidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9] subset: gosubset_prok synonym: "ATP:dTMP phosphotransferase activity" EXACT [EC:2.7.4.9] synonym: "deoxythymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "dTMP kinase activity" EXACT [] synonym: "thymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidine monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylate monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic acid kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic kinase activity" EXACT [EC:2.7.4.9] synonym: "TMPK activity" EXACT [EC:2.7.4.9] xref: EC:2.7.4.9 xref: MetaCyc:DTMPKI-RXN is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004799 name: thymidylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12107] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "dTMP synthase activity" EXACT [EC:2.1.1.45] synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "thymidylate synthetase activity" EXACT [EC:2.1.1.45] synonym: "TMP synthetase activity" EXACT [EC:2.1.1.45] xref: EC:2.1.1.45 xref: KEGG:R02101 xref: MetaCyc:THYMIDYLATESYN-RXN xref: Reactome:14376 "thymidylate synthase activity" xref: RHEA:12107 is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0004800 name: thyroxine 5'-deiodinase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.97.1.10] comment: Note that this was EC:3.8.1.4. synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" EXACT [EC:1.97.1.10] synonym: "diiodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] synonym: "iodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] synonym: "iodothyronine outer ring monodeiodinase activity" EXACT [EC:1.97.1.10] synonym: "L-thyroxine iodohydrolase (reducing) activity" EXACT [EC:1.97.1.10] synonym: "outer ring-deiodinating pathway" EXACT [PMID:20403357] synonym: "thyroxine 5' deiodinase activity" EXACT [] synonym: "thyroxine deiodinase activity" BROAD [] synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] xref: EC:1.97.1.10 xref: MetaCyc:THYROXINE-DEIODINASE-RXN xref: Reactome:15048 "thyroxine 5'-deiodinase activity" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004801 name: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2] subset: gosubset_prok synonym: "dihydroxyacetone transferase activity" BROAD [EC:2.2.1.2] synonym: "dihydroxyacetonetransferase activity" BROAD [EC:2.2.1.2] synonym: "glycerone transferase activity" BROAD [EC:2.2.1.2] synonym: "transaldolase activity" BROAD [EC:2.2.1.2] xref: EC:2.2.1.2 xref: MetaCyc:TRANSALDOL-RXN xref: Reactome:15049 "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity" is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0004802 name: transketolase activity namespace: molecular_function def: "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc] subset: gosubset_prok synonym: "fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [GOC:fmc, GOC:mah] synonym: "glycoaldehyde transferase activity" EXACT [EC:2.2.1.1] synonym: "glycolaldehydetransferase activity" EXACT [EC:2.2.1.1] synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [EC:2.2.1.1] xref: EC:2.2.1.1 xref: MetaCyc:1TRANSKETO-RXN xref: Reactome:15050 "transketolase activity" is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0004803 name: transposase activity namespace: molecular_function alt_id: GO:0004804 def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in site-specific DNA recombination required for transposition in bacteria and other organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "P-element encoded transposase activity" NARROW [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0004805 name: trehalose-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12] subset: gosubset_prok synonym: "trehalose 6-phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose phosphatase activity" EXACT [] synonym: "trehalose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.12] xref: EC:3.1.3.12 xref: MetaCyc:TREHALOSEPHOSPHA-RXN xref: Reactome:15055 "trehalose-phosphatase activity" is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0004806 name: triglyceride lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion." [EC:3.1.1.3] subset: gosubset_prok synonym: "amano AP" RELATED [EC:3.1.1.3] synonym: "amano B" RELATED [EC:3.1.1.3] synonym: "amano CE" RELATED [EC:3.1.1.3] synonym: "amano CES" RELATED [EC:3.1.1.3] synonym: "amano P" RELATED [EC:3.1.1.3] synonym: "amno N-AP" RELATED [EC:3.1.1.3] synonym: "butyrinase activity" EXACT [EC:3.1.1.3] synonym: "cacordase activity" EXACT [EC:3.1.1.3] synonym: "capalase L" RELATED [EC:3.1.1.3] synonym: "GA 56" RELATED [EC:3.1.1.3] synonym: "GEH" RELATED [EC:3.1.1.3] synonym: "glycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "glycerol-ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3] synonym: "lipazin" RELATED [EC:3.1.1.3] synonym: "liver lipase" NARROW [EC:3.1.1.3] synonym: "meito MY 30" RELATED [EC:3.1.1.3] synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3] synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3] synonym: "PPL" RELATED [EC:3.1.1.3] synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3] synonym: "steapsin" RELATED [EC:3.1.1.3] synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3] synonym: "triacetinase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol lipase activity" EXACT [EC:3.1.1.3] synonym: "tributyrase activity" RELATED [EC:3.1.1.3] synonym: "tributyrin esterase activity" EXACT [EC:3.1.1.3] synonym: "tributyrinase activity" EXACT [EC:3.1.1.3] synonym: "triglyceridase activity" EXACT [EC:3.1.1.3] synonym: "triglyceride hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triolein hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween-hydrolyzing esterase activity" EXACT [EC:3.1.1.3] synonym: "tweenase activity" EXACT [EC:3.1.1.3] synonym: "tweenesterase activity" EXACT [EC:3.1.1.3] xref: EC:3.1.1.3 xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN xref: Reactome:15058 "triglyceride lipase activity" is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004807 name: triose-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18588] subset: gosubset_prok synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.1] synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.1] synonym: "phosphotriose isomerase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphate mutase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphoisomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate isomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate mutase activity" EXACT [EC:5.3.1.1] xref: EC:5.3.1.1 xref: KEGG:R01015 xref: MetaCyc:TRIOSEPISOMERIZATION-RXN xref: Reactome:70450 "triose-phosphate isomerase activity" xref: RHEA:18588 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004808 name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity namespace: molecular_function alt_id: GO:0016425 def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" EXACT [EC:2.1.1.61] xref: EC:2.1.1.61 xref: MetaCyc:2.1.1.61-RXN is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004809 name: tRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32] subset: gosubset_prok synonym: "guanine-N2-methylase activity" EXACT [EC:2.1.1.32] synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine N2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer RNA guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA 2,2-dimethylguanosine-26 methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N2-N2) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(m(2,2)G26)dimethyltransferase activity" EXACT [EC:2.1.1.32] xref: EC:2.1.1.32 xref: MetaCyc:TRNA-GUANINE-N2--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0004810 name: tRNA adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.25] subset: gosubset_prok synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP:tRNA adenylyltransferase activity" EXACT [] synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.25] synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate adenyltransferase activity" EXACT [EC:2.7.7.25] synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.25] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.25] xref: EC:2.7.7.25 xref: MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004812 name: aminoacyl-tRNA ligase activity namespace: molecular_function alt_id: GO:0017100 def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA. subset: gosubset_prok synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd] synonym: "aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [] xref: EC:6.1.1.- is_a: GO:0016876 ! ligase activity, forming aminoacyl-tRNA and related compounds [Term] id: GO:0004813 name: alanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7] subset: gosubset_prok synonym: "Ala-tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine translase activity" EXACT [EC:6.1.1.7] synonym: "alanine tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine-transfer RNA ligase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-tRNA synthetase activity" EXACT [] synonym: "AlaRS" RELATED [EC:6.1.1.7] synonym: "L-alanine:tRNAAla ligase (AMP-forming)" EXACT [EC:6.1.1.7] xref: EC:6.1.1.7 xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN xref: Reactome:15078 "alanine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004814 name: arginine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19] subset: gosubset_prok synonym: "arginine translase activity" EXACT [EC:6.1.1.19] synonym: "arginine-tRNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-tRNA synthetase activity" EXACT [] synonym: "L-arginine:tRNAArg ligase (AMP-forming)" EXACT [EC:6.1.1.19] xref: EC:6.1.1.19 xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN xref: Reactome:15079 "arginine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004815 name: aspartate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12] subset: gosubset_prok synonym: "aspartic acid translase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleate synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleic synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-tRNA synthetase activity" EXACT [] synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" EXACT [EC:6.1.1.12] xref: EC:6.1.1.12 xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN xref: Reactome:15081 "aspartate-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004816 name: asparagine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11183] subset: gosubset_prok synonym: "asparagine translase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-tRNA synthetase activity" EXACT [] synonym: "asparagyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" EXACT [EC:6.1.1.22] xref: EC:6.1.1.22 xref: KEGG:R03648 xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN xref: Reactome:15083 "asparagine-tRNA ligase activity" xref: RHEA:11183 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004817 name: cysteine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16] subset: gosubset_prok synonym: "cysteine translase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transferRNA synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-tRNA synthetase activity" EXACT [] synonym: "L-cysteine:tRNACys ligase (AMP-forming)" EXACT [EC:6.1.1.16] xref: EC:6.1.1.16 xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN xref: Reactome:15084 "cysteine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004818 name: glutamate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] subset: gosubset_prok synonym: "glutamate-tRNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamic acid translase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" EXACT [EC:6.1.1.17] xref: EC:6.1.1.17 xref: MetaCyc:GLURS-RXN xref: Reactome:15085 "glutamate-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004819 name: glutamine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18] subset: gosubset_prok synonym: "GlnRS" RELATED [EC:6.1.1.18] synonym: "glutamine translase activity" EXACT [EC:6.1.1.18] synonym: "glutamine-tRNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18] synonym: "glutaminyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" EXACT [EC:6.1.1.18] xref: EC:6.1.1.18 xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN xref: Reactome:15087 "glutamine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004820 name: glycine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14] subset: gosubset_prok synonym: "glycine:tRNAGly ligase (AMP-forming) activity" EXACT [EC:6.1.1.14] synonym: "glycyl translase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.14 xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN xref: Reactome:15097 "glycine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004821 name: histidine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21] subset: gosubset_prok synonym: "histidine translase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-tRNA synthetase activity" EXACT [] synonym: "L-histidine:tRNAHis ligase (AMP-forming)" EXACT [EC:6.1.1.21] xref: EC:6.1.1.21 xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN xref: Reactome:15098 "histidine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004822 name: isoleucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11063] subset: gosubset_prok synonym: "isoleucine translase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-transfer RNA ligase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-tRNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-tRNA synthetase activity" EXACT [] synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [EC:6.1.1.5] xref: EC:6.1.1.5 xref: KEGG:R03656 xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN xref: Reactome:15099 "isoleucine-tRNA ligase activity" xref: RHEA:11063 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004823 name: leucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [EC:6.1.1.4, RHEA:11691] subset: gosubset_prok synonym: "L-leucine:tRNALeu ligase (AMP-forming)" EXACT [EC:6.1.1.4] synonym: "leucine translase activity" EXACT [EC:6.1.1.4] synonym: "leucine-tRNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.4 xref: KEGG:R03657 xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN xref: Reactome:15100 "leucine-tRNA ligase activity" xref: RHEA:11691 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004824 name: lysine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6] subset: gosubset_prok synonym: "L-lysine-transfer RNA ligase activity" EXACT [EC:6.1.1.6] synonym: "L-lysine:tRNALys ligase (AMP-forming)" EXACT [EC:6.1.1.6] synonym: "lysine translase activity" EXACT [EC:6.1.1.6] synonym: "lysine-tRNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.6 xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN xref: Reactome:15101 "lysine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004825 name: methionine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10] subset: gosubset_prok synonym: "L-methionine:tRNAMet ligase (AMP-forming)" EXACT [EC:6.1.1.10] synonym: "methionine translase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-tRNA synthetase activity" EXACT [] synonym: "MetRS activity" EXACT [EC:6.1.1.10] xref: EC:6.1.1.10 xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN xref: Reactome:15102 "methionine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004826 name: phenylalanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] subset: gosubset_prok synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" EXACT [EC:6.1.1.20] synonym: "L-phenylalanyl-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine translase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.20 xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN xref: Reactome:15104 "phenylalanine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004827 name: proline-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15] subset: gosubset_prok synonym: "L-proline:tRNAPro ligase (AMP-forming)" EXACT [EC:6.1.1.15] synonym: "proline translase activity" EXACT [EC:6.1.1.15] synonym: "prolinyl-tRNA ligase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-s-RNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transferRNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.15 xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN xref: Reactome:15107 "proline-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004828 name: serine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] subset: gosubset_prok synonym: "L-serine:tRNASer ligase (AMP-forming)" EXACT [EC:6.1.1.11] synonym: "serine translase activity" EXACT [EC:6.1.1.11] synonym: "SerRS activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer RNA synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.11 xref: MetaCyc:SERINE--TRNA-LIGASE-RXN xref: Reactome:15110 "serine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004829 name: threonine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3] subset: gosubset_prok synonym: "L-threonine:tRNAThr ligase (AMP-forming)" EXACT [EC:6.1.1.3] synonym: "threonine translase activity" EXACT [EC:6.1.1.3] synonym: "threonine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl ribonucleic synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-tRNA synthetase activity" EXACT [] synonym: "TRS" RELATED [EC:6.1.1.3] xref: EC:6.1.1.3 xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN xref: Reactome:15113 "threonine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004830 name: tryptophan-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] subset: gosubset_prok synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" EXACT [EC:6.1.1.2] synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "TrpRS activity" EXACT [EC:6.1.1.2] synonym: "tryptophan translase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.2 xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN xref: Reactome:15130 "tryptophan-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004831 name: tyrosine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10223] subset: gosubset_prok synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" EXACT [EC:6.1.1.1] synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "tyrosine translase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine tRNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer RNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.1 xref: KEGG:R02918 xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN xref: Reactome:15131 "tyrosine-tRNA ligase activity" xref: RHEA:10223 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004832 name: valine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10707] subset: gosubset_prok synonym: "L-valine:tRNAVal ligase (AMP-forming)" EXACT [EC:6.1.1.9] synonym: "valine transfer ribonucleate ligase activity" EXACT [EC:6.1.1.9] synonym: "valine translase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.9 xref: KEGG:R03665 xref: MetaCyc:VALINE--TRNA-LIGASE-RXN xref: Reactome:15132 "valine-tRNA ligase activity" xref: RHEA:10707 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004833 name: tryptophan 2,3-dioxygenase activity namespace: molecular_function alt_id: GO:0004426 def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11] subset: gosubset_prok synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11] synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT [] synonym: "L-tryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan pyrrolase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.11] synonym: "TDO" RELATED [EC:1.13.11.11] synonym: "tryptamin 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptamine 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11] xref: EC:1.13.11.11 xref: MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN xref: Reactome:15133 "tryptophan 2,3-dioxygenase activity" is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004834 name: tryptophan synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [RHEA:10535] subset: gosubset_prok synonym: "indoleglycerol phosphate aldolase activity" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20] synonym: "L-tryptophan synthetase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan desmolase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan synthetase activity" EXACT [EC:4.2.1.20] xref: EC:4.2.1.20 xref: KEGG:R02722 xref: MetaCyc:TRYPSYN-RXN xref: RHEA:10535 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004835 name: tubulin-tyrosine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" EXACT [EC:6.3.2.25] synonym: "TTL activity" EXACT [EC:6.3.2.25] synonym: "tubulinyl-tyrosine ligase activity" EXACT [] xref: EC:6.3.2.25 xref: MetaCyc:6.3.2.25-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004836 name: tyramine-beta hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004837 name: tyrosine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25] synonym: "L-(-)-tyrosine apodecarboxylase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine decarboxylase activity" EXACT [EC:4.1.1.25] xref: EC:4.1.1.25 xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004838 name: L-tyrosine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5] subset: gosubset_prok synonym: "glutamic phenylpyruvic aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" RELATED [EC:2.6.1.5] synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "L-tyrosine aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "phenylalanine aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "phenylalanine transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylpyruvate transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylpyruvic acid transaminase activity" RELATED [EC:2.6.1.5] synonym: "TyrAT activity" RELATED [EC:2.6.1.5] synonym: "tyrosine aminotransferase activity" BROAD [] synonym: "tyrosine transaminase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-2-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate transaminase activity" BROAD [EC:2.6.1.5] xref: EC:2.6.1.5 xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN xref: Reactome:15141 "L-tyrosine:2-oxoglutarate aminotransferase activity" is_a: GO:0070547 ! L-tyrosine aminotransferase activity [Term] id: GO:0004839 name: ubiquitin activating enzyme activity namespace: molecular_function def: "Catalysis of the reaction: a protein L-lysine + a ubiquitin + ATP = a protein-N-ubiquityl-lysine + AMP + diphosphate. This reaction is the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner." [http://www.bostonbiochem.com/E-301.html, PMID:10072378] synonym: "E1" EXACT [] xref: Wikipedia:Ubiquitin-activating_enzyme is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0004842 name: ubiquitin-protein ligase activity namespace: molecular_function alt_id: GO:0004840 alt_id: GO:0004841 def: "Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407] subset: gosubset_prok synonym: "anaphase-promoting complex activity" NARROW [GOC:dph, GOC:tairtb] synonym: "E2" NARROW [] synonym: "E3" NARROW [] synonym: "ubiquitin activity" RELATED [EC:6.3.2.19] synonym: "ubiquitin conjugating enzyme activity" EXACT [] synonym: "ubiquitin ligase activity" EXACT [] synonym: "ubiquitin protein ligase activity" EXACT [] synonym: "ubiquitin protein-ligase activity" EXACT [] synonym: "ubiquitin-conjugating enzyme activity" EXACT [] synonym: "ubiquitin-ligase activity" EXACT [] synonym: "ubiquitin:protein-lysine N-ligase (AMP-forming) activity" EXACT [EC:6.3.2.19] xref: EC:6.3.2.19 xref: KEGG:R03876 xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN xref: Reactome:202455 "ubiquitin-protein ligase activity" is_a: GO:0019787 ! small conjugating protein ligase activity [Term] id: GO:0004843 name: ubiquitin-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences." [ISBN:0120793709] comment: Note that this term is distinguished from 'ubiquitin thiolesterase activity ; GO:0004221' in that it encompasses hydrolysis of any type of bonds formed between ubiquitin and another protein. subset: gosubset_prok synonym: "deubiquitinase" EXACT [GOC:vw, PMID:19261746] synonym: "deubiquitinating enzyme" EXACT [PMID:19188440] synonym: "deubiquitylase" EXACT [GOC:vw, PMID:15657442] synonym: "ubiquitin hydrolase activity" EXACT [GOC:rl] synonym: "UBP" NARROW [] synonym: "UCH2" NARROW [] xref: Reactome:15173 "ubiquitin-specific protease activity" is_a: GO:0019783 ! small conjugating protein-specific protease activity [Term] id: GO:0004844 name: uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, PMID:9224623] subset: gosubset_prok synonym: "uracil-DNA glycosylase activity" EXACT [] xref: EC:3.2.2.- xref: Reactome:15174 "uracil DNA N-glycosylase activity" is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0004845 name: uracil phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [EC:2.4.2.9, RHEA:13020] subset: gosubset_prok synonym: "UMP diphosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UPRTase activity" EXACT [EC:2.4.2.9] synonym: "uridine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylic pyrophosphorylase activity" EXACT [EC:2.4.2.9] xref: EC:2.4.2.9 xref: KEGG:R00966 xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN xref: RHEA:13020 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004846 name: urate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide." [EC:1.7.3.3] subset: gosubset_prok synonym: "urate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.3] synonym: "uric acid oxidase activity" EXACT [EC:1.7.3.3] synonym: "uricase activity" EXACT [EC:1.7.3.3] synonym: "uricase II activity" NARROW [EC:1.7.3.3] xref: EC:1.7.3.3 xref: MetaCyc:URATE-OXIDASE-RXN xref: UM-BBD_reactionID:r1322 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0004847 name: urea carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate." [EC:6.3.4.6, RHEA:20899] subset: gosubset_prok synonym: "ATP--urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "UALase activity" EXACT [EC:6.3.4.6] synonym: "UCA activity" EXACT [EC:6.3.4.6] synonym: "urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolyzing) activity" EXACT [EC:6.3.4.6] synonym: "urea:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolyzing) activity" EXACT [EC:6.3.4.6] xref: EC:6.3.4.6 xref: KEGG:R00774 xref: MetaCyc:UREA-CARBOXYLASE-RXN xref: RHEA:20899 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004848 name: ureidoglycolate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+)." [EC:3.5.3.19, RHEA:19812] subset: gosubset_prok synonym: "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [EC:3.5.3.19] xref: EC:3.5.3.19 xref: KEGG:R00469 xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN xref: RHEA:19812 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004849 name: uridine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48] subset: gosubset_prok synonym: "ATP:uridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.48] synonym: "pyrimidine ribonucleoside kinase activity" EXACT [EC:2.7.1.48] synonym: "uridine kinase (phosphorylating)" EXACT [EC:2.7.1.48] synonym: "uridine kinase reaction" EXACT [] synonym: "uridine monophosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine phosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine-cytidine kinase activity" EXACT [EC:2.7.1.48] xref: EC:2.7.1.48 xref: MetaCyc:URIDINEKIN-RXN is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0004850 name: uridine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3] subset: gosubset_prok synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3] synonym: "UPase activity" EXACT [EC:2.4.2.3] synonym: "UPH" RELATED [EC:2.4.2.3] synonym: "UrdPase activity" EXACT [EC:2.4.2.3] synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.3] xref: EC:2.4.2.3 xref: MetaCyc:URPHOS-RXN xref: Reactome:15196 "uridine phosphorylase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004851 name: uroporphyrin-III C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107] subset: gosubset_prok synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "CobA" RELATED [EC:2.1.1.107] synonym: "CysG" RELATED [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "SirA" RELATED [EC:2.1.1.107] synonym: "SUMT activity" EXACT [EC:2.1.1.107] synonym: "urogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107] xref: EC:2.1.1.107 xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004852 name: uroporphyrinogen-III synthase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18968] subset: gosubset_prok synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" EXACT [EC:4.2.1.75] synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" EXACT [EC:4.2.1.75] synonym: "porphobilinogenase activity" EXACT [EC:4.2.1.75] synonym: "URO-synthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen isomerase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthetase activity" EXACT [EC:4.2.1.75] xref: EC:4.2.1.75 xref: KEGG:R03165 xref: MetaCyc:UROGENIIISYN-RXN xref: Reactome:15200 "uroporphyrinogen-III synthase activity" xref: RHEA:18968 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004853 name: uroporphyrinogen decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37] subset: gosubset_prok synonym: "porphyrinogen carboxy-lyase activity" EXACT [EC:4.1.1.37] synonym: "porphyrinogen decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen III decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase activity" EXACT [EC:4.1.1.37] xref: EC:4.1.1.37 xref: MetaCyc:UROGENDECARBOX-RXN xref: Reactome:15202 "uroporphyrinogen decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004854 name: xanthine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4] subset: gosubset_prok synonym: "NAD-xanthine dehydrogenase activity" EXACT [EC:1.17.1.4] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4] synonym: "xanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] xref: EC:1.17.1.4 xref: MetaCyc:RXN0-901 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0004855 name: xanthine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide." [EC:1.17.3.2] subset: gosubset_prok synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2] synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] synonym: "xanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:xanthine oxidase activity" EXACT [EC:1.17.3.2] xref: EC:1.17.3.2 xref: MetaCyc:XANTHINE-OXIDASE-RXN xref: Reactome:15204 "xanthine oxidase activity" xref: UM-BBD_enzymeID:e0781 is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: GO:0004856 name: xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+)." [EC:2.7.1.17, RHEA:10967] subset: gosubset_prok synonym: "ATP:D-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.17] synonym: "D-xylulokinase activity" EXACT [EC:2.7.1.17] synonym: "xylulokinase (phosphorylating)" EXACT [EC:2.7.1.17] synonym: "xylulose kinase activity" EXACT [EC:2.7.1.17] xref: EC:2.7.1.17 xref: KEGG:R01639 xref: MetaCyc:XYLULOKIN-RXN xref: RHEA:10967 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004857 name: enzyme inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an enzyme." [GOC:ai] subset: gosubset_prok is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0004858 name: dUTP pyrophosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0004859 name: phospholipase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl] is_a: GO:0055102 ! lipase inhibitor activity [Term] id: GO:0004860 name: protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0019210 ! kinase inhibitor activity is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0004861 name: cyclin-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cyclin-dependent protein kinase." [GOC:mah] synonym: "CDK inhibitor" RELATED [] synonym: "cyclin dependent kinase inhibitor" RELATED [] synonym: "cyclin dependent protein kinase inhibitor activity" EXACT [] synonym: "cyclin-dependent kinase inhibitor" RELATED [] xref: Reactome:15226 "cyclin-dependent protein kinase inhibitor activity" is_a: GO:0016538 ! cyclin-dependent protein kinase regulator activity is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity [Term] id: GO:0004862 name: cAMP-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah] xref: Reactome:15228 "cAMP-dependent protein kinase inhibitor activity" is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity [Term] id: GO:0004864 name: protein phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [GOC:ai] synonym: "phosphoprotein phosphatase inhibitor activity" EXACT [GOC:curators] is_a: GO:0019212 ! phosphatase inhibitor activity is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0004865 name: protein serine/threonine phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb] is_a: GO:0004864 ! protein phosphatase inhibitor activity [Term] id: GO:0004866 name: endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] subset: gosubset_prok synonym: "alpha-2 macroglobulin" RELATED [] synonym: "endoproteinase inhibitor" EXACT [] synonym: "proteinase inhibitor" BROAD [] is_a: GO:0030414 ! peptidase inhibitor activity is_a: GO:0061135 ! endopeptidase regulator activity [Term] id: GO:0004867 name: serine-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] subset: gosubset_prok synonym: "serine protease inhibitor activity" EXACT [] synonym: "serine proteinase inhibitor activity" EXACT [] synonym: "serpin activity" NARROW [] xref: Reactome:15233 "serine-type endopeptidase inhibitor activity" is_a: GO:0004866 ! endopeptidase inhibitor activity [Term] id: GO:0004868 name: serpin namespace: molecular_function def: "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0004867 [Term] id: GO:0004869 name: cysteine-type endopeptidase inhibitor activity namespace: molecular_function alt_id: GO:0004870 def: "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb] subset: gosubset_prok synonym: "cysteine protease inhibitor activity" EXACT [GOC:dph, GOC:tb] synonym: "thiol protease inhibitor" EXACT [] is_a: GO:0004866 ! endopeptidase inhibitor activity [Term] id: GO:0004871 name: signal transducer activity namespace: molecular_function alt_id: GO:0005062 alt_id: GO:0009369 alt_id: GO:0009370 def: "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] comment: Ligands do NOT have the molecular function 'signal transducer activity'. subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity" NARROW [] synonym: "quorum sensing response regulator activity" NARROW [] synonym: "quorum sensing signal generator activity" NARROW [] is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0004872 name: receptor activity namespace: molecular_function alt_id: GO:0019041 def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_plant subset: gosubset_prok synonym: "receptor guanylate cyclase activity" NARROW [] synonym: "viral antireceptor activity" NARROW [] is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0004873 name: asialoglycoprotein receptor activity namespace: molecular_function def: "The mediation of the endocytosis of plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed; recognizes the terminal galactose and N-acetylgalactosamine units; the complex of receptor and ligand is internalized and transported to a sorting organelle where disassociation occurs, the receptor being recycled to the cell membrane." [PMID:11278827] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0004874 name: aryl hydrocarbon receptor activity namespace: molecular_function def: "Combining with an aryl hydrocarbon to initiate a change in cell activity." [GOC:ai] is_a: GO:0004872 ! receptor activity [Term] id: GO:0004875 name: complement receptor activity namespace: molecular_function def: "Combining with any component or product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. is_a: GO:0001848 ! complement binding is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0004876 name: complement component C3a receptor activity namespace: molecular_function def: "Combining with the C3a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004877 name: complement component C3b receptor activity namespace: molecular_function def: "Combining with the C3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001850 ! complement component C3a binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004878 name: complement component C5a receptor activity namespace: molecular_function def: "Combining with the C5a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001856 ! complement component C5a binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004879 name: ligand-dependent nuclear receptor activity namespace: molecular_function def: "A ligand-dependent receptor found in the nucleus of the cell." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. synonym: "nuclear hormone receptor" NARROW [] is_a: GO:0004872 ! receptor activity [Term] id: GO:0004880 name: juvenile hormone receptor activity namespace: molecular_function def: "Combining with juvenile hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0004879 ! ligand-dependent nuclear receptor activity [Term] id: GO:0004882 name: androgen receptor activity namespace: molecular_function def: "Combining with an androgen to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0003707 ! steroid hormone receptor activity [Term] id: GO:0004883 name: glucocorticoid receptor activity namespace: molecular_function def: "Combining with a glucocorticoid to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0003707 ! steroid hormone receptor activity [Term] id: GO:0004884 name: ecdysteroid hormone receptor activity namespace: molecular_function def: "Combining with ecdysteroid hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0003707 ! steroid hormone receptor activity [Term] id: GO:0004886 name: retinoid-X receptor activity namespace: molecular_function def: "Combining with 9-cis retinoic acid to initiate a change in cell activity." [PMID:17132853] synonym: "RXR" EXACT [] is_a: GO:0003708 ! retinoic acid receptor activity [Term] id: GO:0004887 name: thyroid hormone receptor activity namespace: molecular_function def: "Combining with thyroid hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0004879 ! ligand-dependent nuclear receptor activity [Term] id: GO:0004888 name: transmembrane receptor activity namespace: molecular_function alt_id: GO:0004926 def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] subset: gosubset_prok synonym: "non G protein coupled 7TM receptor activity" NARROW [] synonym: "non-G-protein coupled 7TM receptor activity" NARROW [] synonym: "non-G-protein-coupled 7TM receptor activity" NARROW [] is_a: GO:0004872 ! receptor activity [Term] id: GO:0004889 name: nicotinic acetylcholine-activated cation-selective channel activity namespace: molecular_function alt_id: GO:0016904 def: "Catalysis of the transmembrane transfer of a cation by a channel that acts as a nicotinic acetylcholine receptor, and opens upon binding acetylcholine." [GOC:mah, PMID:2466967] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0005261 ! cation channel activity [Term] id: GO:0004890 name: GABA-A receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. is_a: GO:0016917 ! GABA receptor activity [Term] id: GO:0004892 name: B cell receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. is_obsolete: true consider: GO:0003823 [Term] id: GO:0004894 name: T cell receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes a receptor type, and not an activity. is_obsolete: true consider: GO:0032394 consider: GO:0032395 consider: GO:0042605 [Term] id: GO:0004895 name: cell adhesion receptor activity namespace: molecular_function def: "OBSOLETE. Combining with cell adhesion molecules to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. is_obsolete: true consider: GO:0005102 consider: GO:0005515 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 [Term] id: GO:0004896 name: cytokine receptor activity namespace: molecular_function alt_id: GO:0004907 def: "Combining with a cytokine to initiate a change in cell activity." [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED [] synonym: "IL receptor" NARROW [] synonym: "interleukin receptor activity" NARROW [] is_a: GO:0004888 ! transmembrane receptor activity is_a: GO:0019955 ! cytokine binding [Term] id: GO:0004897 name: ciliary neurotrophic factor receptor activity namespace: molecular_function def: "Combining with ciliary neurotrophic factor to initiate a change in cell activity." [GOC:mah] synonym: "CNTF receptor activity" EXACT [GOC:mah] synonym: "gp130" RELATED [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004898 name: gp130 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004871 consider: GO:0004897 consider: GO:0004915 consider: GO:0004921 [Term] id: GO:0004900 name: erythropoietin receptor activity namespace: molecular_function def: "Combining with erythropoietin to initiate a change in cell activity." [GOC:ai] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004901 name: granulocyte macrophage colony-stimulating factor receptor activity namespace: molecular_function alt_id: GO:0030525 def: "Combining with granulocyte macrophage colony-stimulating factor to initiate a change in cell activity." [GOC:mah] synonym: "CSF-2" RELATED [] synonym: "GM-CSF receptor activity" EXACT [] synonym: "GMC-SF receptor activity" EXACT [] synonym: "granulocyte macrophage colony stimulating factor receptor activity" EXACT [] is_a: GO:0004900 ! erythropoietin receptor activity [Term] id: GO:0004902 name: granulocyte colony-stimulating factor receptor activity namespace: molecular_function alt_id: GO:0030524 def: "Combining with granulocyte colony-stimulating factor to initiate a change in cell activity." [GOC:mah] synonym: "granulocyte colony stimulating factor receptor activity" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004903 name: growth hormone receptor activity namespace: molecular_function def: "Combining with growth hormone to initiate a change in cell activity." [GOC:ai] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004904 name: interferon receptor activity namespace: molecular_function def: "Combining with an interferon to initiate a change in cell activity." [GOC:ai] synonym: "IFN receptor activity" EXACT [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019961 ! interferon binding [Term] id: GO:0004905 name: type I interferon receptor activity namespace: molecular_function def: "Combining with a type I interferon to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon-alpha receptor activity" NARROW [] synonym: "interferon-alpha/beta receptor activity" NARROW [] synonym: "interferon-beta receptor activity" NARROW [] synonym: "interferon-delta receptor activity" NARROW [] synonym: "interferon-epsilon receptor activity" NARROW [] synonym: "interferon-kappa receptor activity" NARROW [] synonym: "interferon-omega receptor activity" NARROW [] synonym: "interferon-tau receptor activity" NARROW [] synonym: "interferon-zeta receptor activity" NARROW [] synonym: "type I IFN receptor activity" EXACT [GOC:mah] is_a: GO:0004904 ! interferon receptor activity is_a: GO:0019962 ! type I interferon binding [Term] id: GO:0004906 name: interferon-gamma receptor activity namespace: molecular_function def: "Combining with interferon-gamma to initiate a change in cell activity. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383] synonym: "IFN-gamma receptor activity" EXACT [GOC:mah] synonym: "IFNG receptor activity" EXACT [GOC:mah] synonym: "type II interferon receptor activity" EXACT [] is_a: GO:0004904 ! interferon receptor activity is_a: GO:0019964 ! interferon-gamma binding [Term] id: GO:0004908 name: interleukin-1 receptor activity namespace: molecular_function def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl] synonym: "IL-1 receptor activity" EXACT [] synonym: "IL-1R" EXACT [] xref: Wikipedia:Interleukin-1_receptor is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019966 ! interleukin-1 binding [Term] id: GO:0004909 name: interleukin-1, Type I, activating receptor activity namespace: molecular_function alt_id: GO:0019967 def: "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins." [PMID:15062641, PMID:18613828] synonym: "IL-1 type I, activating binding" EXACT [] synonym: "IL-1 type I, activating receptor" EXACT [] synonym: "interleukin-1 activating receptor activity" EXACT [GOC:mah] synonym: "interleukin-1 Type I receptor activity" EXACT [GOC:mah] synonym: "interleukin-1, Type I, activating binding" RELATED [] is_a: GO:0004908 ! interleukin-1 receptor activity [Term] id: GO:0004910 name: interleukin-1, Type II, blocking receptor activity namespace: molecular_function alt_id: GO:0019968 def: "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors." [PMID:15062641, PMID:18613828] synonym: "IL-1 type II, blocking binding" EXACT [] synonym: "IL-1 type II, blocking receptor" EXACT [] synonym: "interleukin-1 blocking receptor activity" EXACT [GOC:mah] synonym: "interleukin-1 Type II receptor activity" EXACT [GOC:mah] synonym: "interleukin-1, Type II, blocking binding" RELATED [] is_a: GO:0004908 ! interleukin-1 receptor activity [Term] id: GO:0004911 name: interleukin-2 receptor activity namespace: molecular_function def: "Combining with interleukin-2 to initiate a change in cell activity." [GOC:jl] synonym: "IL-2 receptor activity" EXACT [GOC:mah] synonym: "IL-2R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019976 ! interleukin-2 binding [Term] id: GO:0004912 name: interleukin-3 receptor activity namespace: molecular_function def: "Combining with interleukin-3 to initiate a change in cell activity." [GOC:jl] synonym: "IL-3 receptor activity" EXACT [GOC:mah] synonym: "IL-3R" EXACT [] xref: Wikipedia:Interleukin-3_receptor is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019978 ! interleukin-3 binding [Term] id: GO:0004913 name: interleukin-4 receptor activity namespace: molecular_function def: "Combining with interleukin-4 to initiate a change in cell activity." [GOC:jl] synonym: "IL-4 receptor activity" EXACT [GOC:mah] synonym: "IL-4R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019979 ! interleukin-4 binding [Term] id: GO:0004914 name: interleukin-5 receptor activity namespace: molecular_function def: "Combining with interleukin-5 to initiate a change in cell activity." [GOC:jl] synonym: "IL-5 receptor activity" EXACT [GOC:mah] synonym: "IL-5R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019980 ! interleukin-5 binding [Term] id: GO:0004915 name: interleukin-6 receptor activity namespace: molecular_function def: "Combining with interleukin-6 to initiate a change in cell activity." [GOC:jl] synonym: "gp130" RELATED [] synonym: "IL-6 receptor activity" EXACT [GOC:mah] synonym: "IL-6R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019981 ! interleukin-6 binding [Term] id: GO:0004917 name: interleukin-7 receptor activity namespace: molecular_function def: "Combining with interleukin-7 to initiate a change in cell activity." [GOC:jl] synonym: "IL-7 receptor activity" EXACT [GOC:mah] synonym: "IL-7R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019982 ! interleukin-7 binding [Term] id: GO:0004918 name: interleukin-8 receptor activity namespace: molecular_function def: "Combining with interleukin-8 to initiate a change in cell activity." [GOC:jl] synonym: "IL-8 receptor activity" EXACT [GOC:mah] synonym: "IL-8R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0016494 ! C-X-C chemokine receptor activity is_a: GO:0019959 ! interleukin-8 binding [Term] id: GO:0004919 name: interleukin-9 receptor activity namespace: molecular_function def: "Combining with interleukin-9 to initiate a change in cell activity." [GOC:jl] synonym: "IL-9 receptor activity" EXACT [GOC:mah] synonym: "IL-9R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019983 ! interleukin-9 binding [Term] id: GO:0004920 name: interleukin-10 receptor activity namespace: molecular_function def: "Combining with interleukin-10 to initiate a change in cell activity." [GOC:jl] synonym: "IL-10 receptor activity" EXACT [GOC:mah] synonym: "IL-10R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019969 ! interleukin-10 binding [Term] id: GO:0004921 name: interleukin-11 receptor activity namespace: molecular_function def: "Combining with interleukin-11 to initiate a change in cell activity." [GOC:jl] synonym: "gp130" RELATED [] synonym: "IL-11 receptor activity" EXACT [GOC:mah] synonym: "IL-11R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019970 ! interleukin-11 binding [Term] id: GO:0004923 name: leukemia inhibitory factor receptor activity namespace: molecular_function alt_id: GO:0004899 def: "Combining with leukemia inhibitory factor to initiate a change in cell activity." [GOC:mah] synonym: "leukemia inhibitory factor receptor beta-protein activity" NARROW [GOC:mah] synonym: "LIF receptor activity" EXACT [GOC:mah] is_a: GO:0004897 ! ciliary neurotrophic factor receptor activity [Term] id: GO:0004924 name: oncostatin-M receptor activity namespace: molecular_function def: "Combining with oncostatin-M to initiate a change in cell activity." [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004925 name: prolactin receptor activity namespace: molecular_function def: "Combining with prolactin to initiate a change in cell activity." [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004927 name: sevenless receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a gene product rather than an activity. is_obsolete: true consider: GO:0004714 consider: GO:0004888 consider: GO:0008288 [Term] id: GO:0004928 name: frizzled receptor activity namespace: molecular_function def: "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product rather than an activity. is_obsolete: true replaced_by: GO:0042813 consider: GO:0016055 [Term] id: GO:0004929 name: frizzled-2 receptor activity namespace: molecular_function def: "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product rather than an activity. is_obsolete: true replaced_by: GO:0042813 consider: GO:0007223 [Term] id: GO:0004930 name: G-protein coupled receptor activity namespace: molecular_function alt_id: GO:0001622 alt_id: GO:0001623 alt_id: GO:0001624 alt_id: GO:0001625 alt_id: GO:0016526 def: "A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers." [GOC:dph, GOC:tb, http://www.iuphar-db.org] subset: gosubset_prok synonym: "EBV-induced receptor" NARROW [] synonym: "Epstein-Barr Virus-induced receptor activity" NARROW [] synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" NARROW [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "G-protein-coupled receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "ligand-dependent GPCR activity" EXACT [] synonym: "Mas proto-oncogene receptor activity" NARROW [] synonym: "orphan G protein coupled receptor activity" NARROW [] synonym: "orphan G-protein coupled receptor activity" NARROW [] synonym: "orphan GPCR activity" NARROW [] synonym: "RDC1 receptor activity" NARROW [] synonym: "SREB receptor" NARROW [] synonym: "super conserved receptor expressed in brain receptor activity" NARROW [] xref: Reactome:35 "G-protein coupled receptor activity" is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0004931 name: extracellular ATP-gated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf, GOC:mah, PMID:9755289] comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'. synonym: "P2X receptor" RELATED [PMID:9755289] synonym: "purinoceptor" BROAD [] synonym: "purinoreceptor" BROAD [] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0005261 ! cation channel activity is_a: GO:0035381 ! ATP-gated ion channel activity [Term] id: GO:0004932 name: mating-type factor pheromone receptor activity namespace: molecular_function def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph] subset: gosubset_prok is_a: GO:0016503 ! pheromone receptor activity [Term] id: GO:0004933 name: mating-type a-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity [Term] id: GO:0004934 name: mating-type alpha-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity [Term] id: GO:0004935 name: adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity." [GOC:mah, IUPHAR_GPCR:1274] synonym: "adrenoceptor activity" EXACT [] xref: Wikipedia:Adrenergic_receptor is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0004936 name: alpha-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha adrenoceptor" EXACT [] is_a: GO:0004935 ! adrenergic receptor activity [Term] id: GO:0004937 name: alpha1-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha1 adrenoceptor" EXACT [] is_a: GO:0004936 ! alpha-adrenergic receptor activity [Term] id: GO:0004938 name: alpha2-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha2 adrenoceptor" EXACT [] is_a: GO:0004936 ! alpha-adrenergic receptor activity [Term] id: GO:0004939 name: beta-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "beta adrenoceptor" EXACT [] is_a: GO:0004935 ! adrenergic receptor activity [Term] id: GO:0004940 name: beta1-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta1 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0004941 name: beta2-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta2 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0004942 name: anaphylatoxin receptor activity namespace: molecular_function def: "Combining with anaphylatoxin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004943 name: C3a anaphylatoxin receptor activity namespace: molecular_function def: "Combining with anaphylatoxin C3a to initiate a change in cell activity." [GOC:mah] is_a: GO:0004942 ! anaphylatoxin receptor activity [Term] id: GO:0004944 name: C5a anaphylatoxin receptor activity namespace: molecular_function def: "Combining with anaphylatoxin C5a to initiate a change in cell activity." [GOC:mah] is_a: GO:0004942 ! anaphylatoxin receptor activity [Term] id: GO:0004945 name: angiotensin type II receptor activity namespace: molecular_function def: "An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms." [GOC:mah, PMID:10977869] is_a: GO:0001595 ! angiotensin receptor activity [Term] id: GO:0004946 name: bombesin receptor activity namespace: molecular_function def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004947 name: bradykinin receptor activity namespace: molecular_function def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004948 name: calcitonin receptor activity namespace: molecular_function def: "Combining with calcitonin to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004949 name: cannabinoid receptor activity namespace: molecular_function def: "Combining with cannabinoids to initiate a change in cell activity." [GOC:dph, IUPHAR_GPCR:1279] synonym: "cannaboid receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004950 name: chemokine receptor activity namespace: molecular_function def: "Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity." [IUPHAR_GPCR:1280, PMID:8662823] is_a: GO:0001637 ! G-protein chemoattractant receptor activity is_a: GO:0019956 ! chemokine binding [Term] id: GO:0004951 name: cholecystokinin receptor activity namespace: molecular_function def: "Combining with a cholecystokinin, any of a group of related neuropeptides secreted by the upper intestinal mucosa and also found in the central nervous system, to initiate a change in cell activity." [GOC:ai, GOC:mah, PMID:9835394] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004952 name: dopamine receptor activity namespace: molecular_function def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282] is_a: GO:0008227 ! G-protein coupled amine receptor activity is_a: GO:0030594 ! neurotransmitter receptor activity is_a: GO:0035240 ! dopamine binding [Term] id: GO:0004953 name: icosanoid receptor activity namespace: molecular_function def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph] synonym: "eicosanoid receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004954 name: prostanoid receptor activity namespace: molecular_function def: "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004953 ! icosanoid receptor activity [Term] id: GO:0004955 name: prostaglandin receptor activity namespace: molecular_function def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004954 ! prostanoid receptor activity [Term] id: GO:0004956 name: prostaglandin D receptor activity namespace: molecular_function def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGD receptor activity" RELATED [] synonym: "PGD(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004957 name: prostaglandin E receptor activity namespace: molecular_function def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGE receptor activity" RELATED [] synonym: "PGE(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004958 name: prostaglandin F receptor activity namespace: molecular_function def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGF receptor activity" RELATED [] synonym: "PGF(2-alpha) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004960 name: thromboxane receptor activity namespace: molecular_function def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "TXA receptor activity" EXACT [] is_a: GO:0004954 ! prostanoid receptor activity [Term] id: GO:0004961 name: thromboxane A2 receptor activity namespace: molecular_function def: "Combining with thromboxane A2 (TXA(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "TXA(2) receptor activity" EXACT [] is_a: GO:0004960 ! thromboxane receptor activity [Term] id: GO:0004962 name: endothelin receptor activity namespace: molecular_function def: "Combining with endothelin to initiate a change in cell activity." [GOC:dph, IUPHAR_GPCR:1283] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004963 name: follicle-stimulating hormone receptor activity namespace: molecular_function def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "follicle stimulating hormone receptor activity" EXACT [] synonym: "FSH receptor activity" EXACT [] is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004964 name: luteinizing hormone receptor activity namespace: molecular_function alt_id: GO:0004976 def: "Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:18848524, PMID:1922095] synonym: "LH receptor" EXACT [PMID:18848524] synonym: "LHR" EXACT [PMID:18848524] synonym: "lutropin receptor" EXACT [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "lutropin-choriogonadotropic hormone receptor" RELATED [PMID:1922095] is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004965 name: GABA-B receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors." [GOC:ai, IUPHAR_RECEPTOR:1276] xref: Reactome:16415 "GABA-B receptor activity" is_a: GO:0008066 ! glutamate receptor activity is_a: GO:0016917 ! GABA receptor activity [Term] id: GO:0004966 name: galanin receptor activity namespace: molecular_function def: "Combining with galanin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004967 name: glucagon receptor activity namespace: molecular_function def: "Combining with glucagon to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004968 name: gonadotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004969 name: histamine receptor activity namespace: molecular_function def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0004970 name: ionotropic glutamate receptor activity namespace: molecular_function def: "Combining with glutamate to initiate a change in cell activity through the regulation of ion channels." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'. subset: gosubset_prok is_a: GO:0008066 ! glutamate receptor activity [Term] id: GO:0004971 name: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity namespace: molecular_function def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. synonym: "AMPA receptor activity" EXACT [] is_a: GO:0004970 ! ionotropic glutamate receptor activity [Term] id: GO:0004972 name: N-methyl-D-aspartate selective glutamate receptor activity namespace: molecular_function def: "An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate." [GOC:mah, PMID:10049997] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. synonym: "NMDA receptor" EXACT [] xref: Wikipedia:NMDA_receptor is_a: GO:0004970 ! ionotropic glutamate receptor activity [Term] id: GO:0004973 name: N-methyl-D-aspartate receptor-associated protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0004974 name: leukotriene receptor activity namespace: molecular_function def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004977 name: melanocortin receptor activity namespace: molecular_function def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004978 name: corticotropin receptor activity namespace: molecular_function def: "Combining with corticotropin to initiate a change in cell activity." [GOC:ai] synonym: "ACTH receptor activity" EXACT [] synonym: "adrenocorticotropic hormone receptor activity" EXACT [] synonym: "adrenocorticotropin receptor activity" EXACT [] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0008188 ! neuropeptide receptor activity is_a: GO:0042562 ! hormone binding [Term] id: GO:0004979 name: beta-endorphin receptor activity namespace: molecular_function def: "Combining with beta-endorphin to initiate a change in cell activity." [GOC:ai] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004980 name: melanocyte-stimulating hormone receptor activity namespace: molecular_function def: "Combining with melanocyte-stimulating hormone to initiate a change in cell activity." [GOC:jl, PMID:7581459] synonym: "melanocyte stimulating hormone receptor activity" EXACT [] synonym: "melanophore-stimulating hormone receptor activity" EXACT [] synonym: "MSH receptor activity" BROAD [] synonym: "MSHR activity" BROAD [] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0042562 ! hormone binding [Term] id: GO:0004981 name: muscarinic acetylcholine receptor activity namespace: molecular_function def: "Combining with acetylcholine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of muscarinic receptors." [GOC:mah, IUPHAR_GPCR:1271] is_a: GO:0016907 ! G-protein coupled acetylcholine receptor activity [Term] id: GO:0004982 name: N-formyl peptide receptor activity namespace: molecular_function def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai] synonym: "Fmet-leu-phe receptor" EXACT [] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004983 name: neuropeptide Y receptor activity namespace: molecular_function def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004984 name: olfactory receptor activity namespace: molecular_function def: "Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell." [GOC:dph] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004985 name: opioid receptor activity namespace: molecular_function def: "Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity." [GOC:ai, PMID:20494127] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004986 name: delta-opioid receptor activity namespace: molecular_function def: "Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands." [IUPHAR_RECEPTOR:317, PMID:10471416] xref: Wikipedia:Delta_Opioid_receptor is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0004987 name: kappa-opioid receptor activity namespace: molecular_function def: "Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins." [IUPHAR_RECEPTOR:318] xref: Wikipedia:Kappa_Opioid_receptor is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0004988 name: mu-opioid receptor activity namespace: molecular_function def: "Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins." [IUPHAR_RECEPTOR:319] xref: Wikipedia:Mu_Opioid_receptor is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0004989 name: octopamine receptor activity namespace: molecular_function def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai] is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0004990 name: oxytocin receptor activity namespace: molecular_function def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004991 name: parathyroid hormone receptor activity namespace: molecular_function def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004992 name: platelet activating factor receptor activity namespace: molecular_function def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah] synonym: "PAF receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004993 name: serotonin receptor activity namespace: molecular_function alt_id: GO:0001585 alt_id: GO:0016609 def: "Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity." [CHEBI:28790, GOC:ai] synonym: "5-HT receptor" EXACT [] synonym: "5-hydroxytryptamine receptor" EXACT [] synonym: "G protein coupled serotonin receptor activity" EXACT [] synonym: "G-protein coupled serotonin receptor activity" EXACT [] synonym: "G-protein-coupled serotonin receptor activity" EXACT [] xref: Wikipedia:5-HT_receptor is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0004994 name: somatostatin receptor activity namespace: molecular_function def: "Combining with somatostatin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004995 name: tachykinin receptor activity namespace: molecular_function def: "Combining with tachykinin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004996 name: thyroid-stimulating hormone receptor activity namespace: molecular_function def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "thyroid stimulating hormone receptor activity" EXACT [] synonym: "thyrotropin receptor" EXACT [] synonym: "TSH receptor activity" EXACT [] xref: Wikipedia:Thyrotropin_receptor is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004997 name: thyrotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004998 name: transferrin receptor activity namespace: molecular_function def: "Combining with transferrin to initiate a change in cell activity." [GOC:mah] subset: gosubset_prok is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0004999 name: vasoactive intestinal polypeptide receptor activity namespace: molecular_function def: "Combining with vasoactive intestinal polypeptide to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0005000 name: vasopressin receptor activity namespace: molecular_function alt_id: GO:0016931 def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] synonym: "vasopressin activated calcium mobilizing receptor activity" NARROW [] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0005001 name: transmembrane receptor protein tyrosine phosphatase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] is_a: GO:0004725 ! protein tyrosine phosphatase activity is_a: GO:0019198 ! transmembrane receptor protein phosphatase activity [Term] id: GO:0005003 name: ephrin receptor activity namespace: molecular_function def: "Combining with an ephrin to initiate a change in cell activity." [GOC:mah] synonym: "Eph receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005004 name: GPI-linked ephrin receptor activity namespace: molecular_function def: "Combining with a GPI-anchored ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] synonym: "GPI-linked Eph receptor activity" EXACT [] is_a: GO:0005003 ! ephrin receptor activity [Term] id: GO:0005005 name: transmembrane-ephrin receptor activity namespace: molecular_function def: "Combining with a transmembrane ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] synonym: "transmembrane-Eph receptor activity" EXACT [] is_a: GO:0005003 ! ephrin receptor activity [Term] id: GO:0005006 name: epidermal growth factor receptor activity namespace: molecular_function alt_id: GO:0005023 def: "Combining with an epidermal growth factor to initiate a change in cell activity." [GOC:bf] subset: gosubset_prok synonym: "EGF receptor activity" EXACT [] synonym: "EGFR" EXACT [] synonym: "TGF-alpha receptor activity" EXACT [] synonym: "transforming growth factor-alpha receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005007 name: fibroblast growth factor receptor activity namespace: molecular_function def: "Combining with fibroblast growth factor to initiate a change in cell activity." [GOC:mah] synonym: "FGF receptor activity" EXACT [] synonym: "FGFR" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005008 name: hepatocyte growth factor receptor activity namespace: molecular_function def: "Combining with hepatocye growth factor to initiate a change in cell activity." [GOC:mah] synonym: "HGF receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005009 name: insulin receptor activity namespace: molecular_function def: "Combining with insulin to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005010 name: insulin-like growth factor receptor activity namespace: molecular_function def: "Combining with an insulin-like growth factor to initiate a change in cell activity." [GOC:mah] synonym: "IGF receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005011 name: macrophage colony-stimulating factor receptor activity namespace: molecular_function def: "Combining with macrophage colony-stimulating factor to initiate a change in cell activity." [GOC:mah] synonym: "CSF-1" NARROW [] synonym: "Fms" NARROW [] synonym: "macrophage colony stimulating factor receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005012 name: Neu/ErbB-2 receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a class of receptor rather than an activity. is_obsolete: true consider: GO:0043125 [Term] id: GO:0005013 name: neurotrophin TRK receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0019838 consider: GO:0043121 [Term] id: GO:0005014 name: neurotrophin TRKA receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0048404 consider: GO:0048406 [Term] id: GO:0005015 name: neurotrophin TRKB receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0048403 consider: GO:0048404 consider: GO:0048405 [Term] id: GO:0005016 name: neurotrophin TRKC receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0048404 [Term] id: GO:0005017 name: platelet-derived growth factor receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor to initiate a change in cell activity." [GOC:mah] synonym: "PDGF receptor activity" EXACT [] synonym: "PDGFR activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005018 name: platelet-derived growth factor alpha-receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917] synonym: "alphaPDGF receptor activity" EXACT [PMID:10372961] synonym: "PDGF alpha-receptor activity" EXACT [] is_a: GO:0005017 ! platelet-derived growth factor receptor activity [Term] id: GO:0005019 name: platelet-derived growth factor beta-receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917] synonym: "betaPDGF receptor activity" RELATED [PMID:10372961] synonym: "PDGF beta-receptor activity" EXACT [] is_a: GO:0005017 ! platelet-derived growth factor receptor activity [Term] id: GO:0005020 name: stem cell factor receptor activity namespace: molecular_function def: "Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity." [GOC:jl, PMID:10698217] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005021 name: vascular endothelial growth factor receptor activity namespace: molecular_function def: "Combining with vascular endothelial growth factor to initiate a change in cell activity." [GOC:mah] synonym: "VEGF receptor activity" EXACT [] synonym: "VEGFR activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005024 name: transforming growth factor beta receptor activity namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity." [GOC:mah] synonym: "TGF-beta receptor activity" EXACT [] synonym: "TGFbeta receptor activity" EXACT [] synonym: "TGFbetaR" EXACT [] is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity [Term] id: GO:0005025 name: transforming growth factor beta receptor activity, type I namespace: molecular_function def: "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals." [GOC:mah, Reactome:REACT_6945.1] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "type I TGF-beta receptor activity" EXACT [] synonym: "type I TGFbeta receptor activity" EXACT [] synonym: "type I transforming growth factor beta receptor activity" EXACT [] is_a: GO:0005024 ! transforming growth factor beta receptor activity [Term] id: GO:0005026 name: transforming growth factor beta receptor activity, type II namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah, Reactome:REACT_6872.1] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "type II TGF-beta receptor activity" EXACT [] synonym: "type II TGFbeta receptor activity" EXACT [] synonym: "type II transforming growth factor beta receptor activity" EXACT [] xref: Reactome:11166 "transforming growth factor beta receptor activity, type II" is_a: GO:0005024 ! transforming growth factor beta receptor activity [Term] id: GO:0005027 name: NGF/TNF (6 C-domain) receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a protein family rather than a molecular function. is_obsolete: true consider: GO:0005031 [Term] id: GO:0005028 name: CD40 receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. is_obsolete: true consider: GO:0042615 [Term] id: GO:0005029 name: CD27 receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. is_obsolete: true consider: GO:0042614 [Term] id: GO:0005030 name: neurotrophin receptor activity namespace: molecular_function def: "Combining with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth, to initiate a change in cell activity." [GOC:jl, http://www.mercksource.com/] is_a: GO:0004872 ! receptor activity is_a: GO:0043121 ! neurotrophin binding [Term] id: GO:0005031 name: tumor necrosis factor receptor activity namespace: molecular_function alt_id: GO:0005032 alt_id: GO:0005033 def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/] synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW [] synonym: "TNF receptor activity" EXACT [] synonym: "TNF receptor activity, type I" NARROW [] synonym: "TNF receptor activity, type II" NARROW [] synonym: "tumor necrosis factor receptor activity, type I" NARROW [] synonym: "tumor necrosis factor receptor activity, type II" NARROW [] is_a: GO:0005035 ! death receptor activity is_a: GO:0043120 ! tumor necrosis factor binding [Term] id: GO:0005034 name: osmosensor activity namespace: molecular_function def: "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005035 name: death receptor activity namespace: molecular_function def: "Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptosis." [GOC:bf, GOC:ecd, PMID:10209153] synonym: "apoptosis-activating receptor activity" RELATED [GOC:bf] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005037 name: death receptor adaptor protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005038 name: death receptor interacting protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005039 name: death receptor-associated factor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005040 name: decoy death receptor activity namespace: molecular_function def: "Combining with an extracellular messenger (death ligand) without transmission of the signal. Decoy death receptors compete with death receptors for ligand binding, and do not initiate apoptosis." [GOC:bf, GOC:ecd, PMID:10209153] is_a: GO:0005488 ! binding [Term] id: GO:0005041 name: low-density lipoprotein receptor activity namespace: molecular_function alt_id: GO:0008032 def: "Combining with a low-density lipoprotein particle to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "LDL receptor" EXACT [] synonym: "low-density lipoprotein receptor activity" EXACT [GOC:dph] xref: Wikipedia:LDL_receptor is_a: GO:0030169 ! low-density lipoprotein particle binding is_a: GO:0030228 ! lipoprotein particle receptor activity [Term] id: GO:0005042 name: netrin receptor activity namespace: molecular_function def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemotaxis when activated." [GOC:dph] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005043 name: repulsive netrin receptor activity namespace: molecular_function def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemorepulsion when activated." [GOC:dph] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005044 name: scavenger receptor activity namespace: molecular_function def: "Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity." [PMID:11790542, PMID:12379907, PMID:12621157] comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. subset: gosubset_prok synonym: "macrophage receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005045 name: endoplasmic reticulum receptor activity namespace: molecular_function def: "OBSOLETE. A receptor in the endoplasmic reticulum." [GOC:ai] comment: This term was made obsolete because it represents cellular component and molecular function information. is_obsolete: true replaced_by: GO:0004872 replaced_by: GO:0005783 [Term] id: GO:0005046 name: KDEL sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai] synonym: "KDEL receptor activity" NARROW [] is_a: GO:0046923 ! ER retention sequence binding [Term] id: GO:0005047 name: signal recognition particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with the signal recognition particle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'. subset: gosubset_prok synonym: "docking protein" BROAD [] synonym: "signal recognition particle receptor" NARROW [] xref: Reactome:11266 "signal recognition particle binding" is_a: GO:0043021 ! ribonucleoprotein binding [Term] id: GO:0005048 name: signal sequence binding namespace: molecular_function alt_id: GO:0008249 def: "Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] subset: gosubset_prok synonym: "leader sequence binding" NARROW [] synonym: "protein signal sequence binding" NARROW [] synonym: "signal sequence receptor" NARROW [] xref: Reactome:11268 "signal sequence binding" is_a: GO:0042277 ! peptide binding [Term] id: GO:0005049 name: nuclear export signal receptor activity namespace: molecular_function def: "Combining with a nuclear export signal to initiate a change in cell activity." [GOC:ai] synonym: "NES receptor" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005050 name: peroxisome receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular component. is_obsolete: true consider: GO:0004872 consider: GO:0005777 [Term] id: GO:0005052 name: peroxisome matrix targeting signal-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502] synonym: "peroxisome targeting signal-1 binding" EXACT [] synonym: "peroxisome targeting signal-1 receptor" NARROW [] synonym: "PEX5" NARROW [] synonym: "PTS1 receptor" NARROW [] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0005053 name: peroxisome matrix targeting signal-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502] synonym: "peroxisome targeting signal-2 binding" EXACT [] synonym: "peroxisome targeting signal-2 receptor" NARROW [] synonym: "PEX7" NARROW [] synonym: "PTS2 receptor" EXACT [] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0005054 name: peroxisome integral membrane receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular component. synonym: "Pas20p" RELATED [] is_obsolete: true consider: GO:0004872 consider: GO:0005778 [Term] id: GO:0005055 name: laminin receptor activity namespace: molecular_function def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. subset: gosubset_prok is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005056 name: tiggrin receptor activity namespace: molecular_function def: "Combining with the extracellular matrix ligand tiggrin to initiate a change in cell activity." [GOC:mah, PMID:9521906] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005057 name: receptor signaling protein activity namespace: molecular_function def: "Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf] comment: This term is intended for annotation of signal transducers that act directly or indirectly downstream of a receptor. For receptors themselves, consider annotating to the term 'receptor activity ; GO:0004872'. synonym: "receptor signalling protein activity" EXACT [] is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0005061 name: aryl hydrocarbon receptor nuclear translocator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0005065 name: heterotrimeric G-protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a cellular component and not a molecular function. is_obsolete: true replaced_by: GO:0005834 [Term] id: GO:0005066 name: transmembrane receptor protein tyrosine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0004871 consider: GO:0007169 consider: GO:0035556 [Term] id: GO:0005068 name: transmembrane receptor protein tyrosine kinase adaptor activity namespace: molecular_function alt_id: GO:0005069 def: "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848] synonym: "transmembrane receptor protein tyrosine kinase adaptor protein activity" EXACT [] synonym: "transmembrane receptor protein tyrosine kinase docking protein activity" RELATED [] xref: Reactome:11343 "transmembrane receptor protein tyrosine kinase adaptor activity" is_a: GO:0030674 ! protein binding, bridging is_a: GO:0030971 ! receptor tyrosine kinase binding is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0005070 name: SH3/SH2 adaptor activity namespace: molecular_function def: "Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so] synonym: "SH3/SH2 adaptor protein activity" NARROW [] is_a: GO:0030674 ! protein binding, bridging is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0005071 name: transmembrane receptor protein serine/threonine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0004871 consider: GO:0007178 consider: GO:0035556 [Term] id: GO:0005072 name: transforming growth factor beta receptor, cytoplasmic mediator activity namespace: molecular_function def: "Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd] comment: Note that this term and its children are useful for annotating proteins of the SMAD family. synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT [] is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0005073 name: common-partner SMAD protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it names a family of gene products. is_obsolete: true replaced_by: GO:0030616 [Term] id: GO:0005074 name: inhibitory SMAD protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it names a family of gene products. is_obsolete: true replaced_by: GO:0030617 [Term] id: GO:0005075 name: pathway-specific SMAD protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a family of gene products. is_obsolete: true replaced_by: GO:0030618 [Term] id: GO:0005076 name: receptor signaling protein serine/threonine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0004871 consider: GO:0035556 [Term] id: GO:0005077 name: MAP-kinase anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location." [GOC:ai] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "MAP-kinase anchor protein activity" EXACT [] is_obsolete: true replaced_by: GO:0008104 replaced_by: GO:0051019 [Term] id: GO:0005078 name: MAP-kinase scaffold activity namespace: molecular_function def: "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336] synonym: "MAP-kinase scaffold protein activity" EXACT [] is_a: GO:0032947 ! protein complex scaffold is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0005079 name: protein kinase A anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "A-kinase anchor protein activity" EXACT [] synonym: "AKAP activity" EXACT [] is_obsolete: true replaced_by: GO:0008104 replaced_by: GO:0051018 [Term] id: GO:0005080 name: protein kinase C binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein kinase C." [GOC:jl] synonym: "PKC binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0005081 name: receptor signaling protein serine/threonine phosphatase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0004871 consider: GO:0035556 [Term] id: GO:0005082 name: receptor signaling protein tyrosine phosphatase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0004871 consider: GO:0035556 [Term] id: GO:0005083 name: small GTPase regulator activity namespace: molecular_function def: "Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah] subset: gosubset_prok synonym: "small GTPase regulatory/interacting protein activity" RELATED [] is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005085 name: guanyl-nucleotide exchange factor activity namespace: molecular_function alt_id: GO:0008433 alt_id: GO:0016219 alt_id: GO:0019839 def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] subset: gosubset_prok synonym: "GDP-dissociation stimulator activity" EXACT [] synonym: "GDS" EXACT [] synonym: "GEF" EXACT [] synonym: "GNRP" NARROW [] synonym: "guanyl-nucleotide release factor activity" EXACT [] synonym: "guanyl-nucleotide releasing factor" EXACT [] xref: Reactome:11431 "guanyl-nucleotide exchange factor activity" is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005086 name: ARF guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:11434 "ARF guanyl-nucleotide exchange factor activity" is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0005087 name: Ran guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "RCC1" EXACT [] xref: Reactome:11435 "Ran guanyl-nucleotide exchange factor activity" xref: Wikipedia:RCC1 is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0005088 name: Ras guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:11436 "Ras guanyl-nucleotide exchange factor activity" is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0005089 name: Rho guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "Rho guanine nucleotide exchange factor" EXACT [] synonym: "RhoGEF" EXACT [] xref: Reactome:11437 "Rho guanyl-nucleotide exchange factor activity" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0005090 name: Sar guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] comment: Note that the name Sar derives from 'secretion-associated, Ras-related'. is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0005091 name: guanyl-nucleotide exchange factor adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0005092 name: GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah] synonym: "GDI" EXACT [] is_a: GO:0005083 ! small GTPase regulator activity [Term] id: GO:0005093 name: Rab GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah] is_a: GO:0005092 ! GDP-dissociation inhibitor activity [Term] id: GO:0005094 name: Rho GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah] is_a: GO:0005092 ! GDP-dissociation inhibitor activity [Term] id: GO:0005095 name: GTPase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai] synonym: "GIP" BROAD [] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005096 name: GTPase activator activity namespace: molecular_function def: "Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] subset: gosubset_prok synonym: "GAP activity" EXACT [] xref: Reactome:11473 "GTPase activator activity" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005097 name: Rab GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah] synonym: "Rab GAP activity" EXACT [GOC:pg] is_a: GO:0005099 ! Ras GTPase activator activity [Term] id: GO:0005098 name: Ran GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Ran family." [GOC:mah] synonym: "Ran GAP activity" EXACT [GOC:pg] synonym: "RanGAP" RELATED [] is_a: GO:0005099 ! Ras GTPase activator activity [Term] id: GO:0005099 name: Ras GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily." [GOC:mah] synonym: "Ras GAP activity" EXACT [GOC:pg] is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005096 ! GTPase activator activity [Term] id: GO:0005100 name: Rho GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rho family." [GOC:mah] synonym: "Rho GAP activity" EXACT [GOC:pg] xref: Reactome:12052 "Rho GTPase activator activity" is_a: GO:0005099 ! Ras GTPase activator activity [Term] id: GO:0005101 name: Sar GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Sar family." [GOC:mah] comment: Note that the name Sar derives from 'secretion-associated, Ras-related'. synonym: "Sar GAP activity" EXACT [GOC:pg] is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005096 ! GTPase activator activity [Term] id: GO:0005102 name: receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_plant subset: gosubset_prok synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: Wikipedia:Ligand_(biochemistry) is_a: GO:0005515 ! protein binding [Term] id: GO:0005104 name: fibroblast growth factor receptor binding namespace: molecular_function alt_id: GO:0001521 alt_id: GO:0005162 def: "Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR)." [GOC:ceb] comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor. synonym: "FGF receptor binding" EXACT [] synonym: "FGFR binding" EXACT [] synonym: "FGFR ligand" NARROW [] synonym: "fibroblast growth factor" BROAD [] synonym: "fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005105 name: type 1 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators] comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1). synonym: "breathless binding" NARROW [] synonym: "breathless ligand" NARROW [] synonym: "FGFR1 binding" BROAD [] synonym: "FGFR1 ligand" NARROW [] synonym: "type 1 fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0005104 ! fibroblast growth factor receptor binding [Term] id: GO:0005106 name: ephrin namespace: molecular_function def: "OBSOLETE. A class of proteins that interact with the ephrin receptors." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0046875 [Term] id: GO:0005107 name: GPI-linked ephrin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0046658 consider: GO:0046875 [Term] id: GO:0005108 name: transmembrane ephrin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0005887 consider: GO:0046875 [Term] id: GO:0005109 name: frizzled binding namespace: molecular_function def: "Interacting selectively and non-covalently with the frizzled (fz) receptor." [GOC:ceb] synonym: "frizzled ligand" NARROW [] synonym: "fz binding" EXACT [] synonym: "fz ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0005110 name: frizzled-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with frizzled-2 (fz2)." [GOC:ceb] synonym: "frizzled-2 ligand" NARROW [] synonym: "fz2 binding" EXACT [] synonym: "fz2 ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0005111 name: type 2 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators] comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2). synonym: "FGFR2 binding" EXACT [] synonym: "FGFR2 ligand" NARROW [] synonym: "heartless binding" EXACT [] synonym: "heartless ligand" NARROW [] synonym: "type 2 fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0005104 ! fibroblast growth factor receptor binding [Term] id: GO:0005112 name: Notch binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb] synonym: "N binding" EXACT [] synonym: "N ligand" NARROW [] synonym: "Notch ligand" NARROW [] synonym: "Notch receptor binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005113 name: patched binding namespace: molecular_function def: "Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473] synonym: "patched ligand" NARROW [] synonym: "ptc binding" EXACT [] synonym: "ptc ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005114 name: type II transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892] synonym: "punt binding" NARROW [] synonym: "punt ligand" NARROW [] synonym: "TGF-beta type II binding" EXACT [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor type II binding" EXACT [] synonym: "type II TGF-beta binding" EXACT [] is_a: GO:0005160 ! transforming growth factor beta receptor binding [Term] id: GO:0005115 name: receptor tyrosine kinase-like orphan receptor binding namespace: molecular_function def: "Interaction with the receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb] synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW [] synonym: "Ror binding" BROAD [] synonym: "Ror ligand" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005117 name: wishful thinking binding namespace: molecular_function def: "Interacting selectively and non-covalently with wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529] synonym: "SE20 receptor binding" NARROW [] synonym: "wishful thinking ligand" NARROW [] synonym: "Wit binding" EXACT [] synonym: "Wit ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005118 name: sevenless binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:3151175] synonym: "sev binding" EXACT [] synonym: "sev ligand" NARROW [] synonym: "sevenless ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005119 name: smoothened binding namespace: molecular_function def: "Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473] synonym: "smo binding" EXACT [] synonym: "smo ligand" NARROW [] synonym: "smoothened ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005121 name: Toll binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb] synonym: "Tl binding" EXACT [] synonym: "Toll ligand" NARROW [] synonym: "Toll receptor binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005122 name: torso binding namespace: molecular_function def: "Interacting selectively and non-covalently with the torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509] synonym: "tor binding" EXACT [] synonym: "tor ligand" NARROW [] synonym: "torso ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005123 name: death receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015] synonym: "APO binding" NARROW [GOC:rl] synonym: "death receptor adaptor protein activity" RELATED [] synonym: "death receptor interacting protein activity" RELATED [] synonym: "death receptor ligand" NARROW [] synonym: "death receptor-associated factor activity" RELATED [] synonym: "DR binding" NARROW [GOC:rl] synonym: "EDAR binding" NARROW [GOC:rl] synonym: "FAS binding" NARROW [GOC:rl] synonym: "KILLER binding" NARROW [GOC:rl] synonym: "NGFR binding" NARROW [GOC:rl] synonym: "TNFR1 binding" NARROW [GOC:rl] synonym: "TRAIL binding" NARROW [GOC:rl] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005124 name: scavenger receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb] synonym: "scavenger receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005125 name: cytokine activity namespace: molecular_function def: "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471] synonym: "autocrine activity" RELATED [GOC:rl] synonym: "paracrine activity" RELATED [GOC:rl] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005126 name: cytokine receptor binding namespace: molecular_function def: "Interacting selectively with a cytokine receptor." [GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005127 name: ciliary neurotrophic factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor." [GOC:ai] synonym: "ciliary neurotrophic factor" NARROW [] synonym: "ciliary neurotrophic factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005128 name: erythropoietin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the erythropoietin receptor." [GOC:ai] synonym: "erythropoietin" NARROW [] synonym: "erythropoietin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005129 name: granulocyte macrophage colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor." [GOC:ai] synonym: "GM-CSF receptor ligand" NARROW [] synonym: "GMC-SF receptor ligand" NARROW [] synonym: "granulocyte macrophage colony stimulating factor receptor binding" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor" NARROW [] synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005130 name: granulocyte colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor." [GOC:ai] synonym: "G-CSF receptor ligand" EXACT [] synonym: "GC-SF receptor ligand" EXACT [] synonym: "granulocyte colony stimulating factor receptor binding" EXACT [] synonym: "granulocyte colony-stimulating factor" NARROW [] synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005131 name: growth hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the growth hormone receptor." [GOC:ai] synonym: "growth hormone" NARROW [] synonym: "growth hormone receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0051427 ! hormone receptor binding [Term] id: GO:0005132 name: interferon-alpha/beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interferon-alpha/beta receptor." [GOC:ai] synonym: "interferon-alpha/beta" NARROW [] synonym: "interferon-alpha/beta receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005133 name: interferon-gamma receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interferon-gamma receptor." [GOC:ai] synonym: "interferon-gamma" NARROW [] synonym: "interferon-gamma receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005134 name: interleukin-2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-2 receptor." [GOC:ai] synonym: "IL-2" NARROW [] synonym: "interleukin-2 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005135 name: interleukin-3 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-3 receptor." [GOC:ai] synonym: "IL-3" NARROW [] synonym: "interleukin-3 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005136 name: interleukin-4 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-4 receptor." [GOC:ai] synonym: "IL-4" NARROW [] synonym: "interleukin-4 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005137 name: interleukin-5 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-5 receptor." [GOC:ai] synonym: "IL-5" NARROW [] synonym: "interleukin-5 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005138 name: interleukin-6 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-6 receptor." [GOC:ai] synonym: "IL-6" NARROW [] synonym: "interleukin-6 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005139 name: interleukin-7 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-7 receptor." [GOC:ai] synonym: "IL-7" NARROW [] synonym: "interleukin-7 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005140 name: interleukin-9 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-9 receptor." [GOC:ai] synonym: "IL-9" NARROW [] synonym: "interleukin-9 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005141 name: interleukin-10 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-10 receptor." [GOC:ai] synonym: "IL-10" NARROW [] synonym: "interleukin-10 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005142 name: interleukin-11 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-11 receptor." [GOC:ai] synonym: "IL-11" NARROW [] synonym: "interleukin-11 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005143 name: interleukin-12 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-12 receptor." [GOC:ai] synonym: "IL-12" NARROW [] synonym: "interleukin-12 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005144 name: interleukin-13 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-13 receptor." [GOC:ai] synonym: "IL-13" NARROW [] synonym: "interleukin-13 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005145 name: interleukin-14 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-14 receptor." [GOC:ai] synonym: "IL-14" NARROW [] synonym: "interleukin-14 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005146 name: leukemia inhibitory factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the leukemia inhibitory factor receptor." [GOC:ai] synonym: "leukemia inhibitory factor" NARROW [] synonym: "leukemia inhibitory factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005147 name: oncostatin-M receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oncostatin-M receptor." [GOC:ai] synonym: "oncostatin-M" NARROW [] synonym: "oncostatin-M receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005148 name: prolactin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the prolactin receptor." [GOC:ai] synonym: "prolactin" NARROW [] synonym: "prolactin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005149 name: interleukin-1 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-1 receptor." [GOC:go_curators] synonym: "IL-1" NARROW [] synonym: "interleukin-1 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005150 name: interleukin-1, Type I receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Type I interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type I" NARROW [] synonym: "interleukin-1, Type I receptor ligand" NARROW [] is_a: GO:0005149 ! interleukin-1 receptor binding [Term] id: GO:0005151 name: interleukin-1, Type II receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Type II interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type II" NARROW [] synonym: "interleukin-1, Type II receptor ligand" NARROW [] is_a: GO:0005149 ! interleukin-1 receptor binding [Term] id: GO:0005152 name: interleukin-1 receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc] synonym: "IL-1ra" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0048019 ! receptor antagonist activity [Term] id: GO:0005153 name: interleukin-8 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-8 receptor." [GOC:go_curators] synonym: "IL-8" NARROW [] synonym: "interleukin-8 receptor ligand" NARROW [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0005154 name: epidermal growth factor receptor binding namespace: molecular_function alt_id: GO:0008185 def: "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai] synonym: "EGF" NARROW [] synonym: "EGF receptor binding" EXACT [] synonym: "EGF receptor ligand" NARROW [] synonym: "EGFR binding" EXACT [] synonym: "epidermal growth factor" NARROW [] synonym: "epidermal growth factor receptor ligand" NARROW [] synonym: "TGF-alpha receptor binding" EXACT [] synonym: "TGFalpha receptor binding" EXACT [] synonym: "transforming growth factor alpha" NARROW [] synonym: "transforming growth factor alpha receptor binding" EXACT [] synonym: "transforming growth factor alpha receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005155 name: epidermal growth factor receptor activating ligand activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it represents both a biological process and a molecular function. synonym: "EGF receptor activating ligand activity" EXACT [] synonym: "EGFR activating ligand activity" EXACT [] is_obsolete: true replaced_by: GO:0005154 consider: GO:0030297 consider: GO:0045741 [Term] id: GO:0005156 name: epidermal growth factor receptor inhibiting ligand activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it represents both a biological process and a molecular function. synonym: "EGF receptor inhibiting ligand activity" EXACT [] synonym: "EGFR inhibiting ligand activity" EXACT [] is_obsolete: true replaced_by: GO:0005154 consider: GO:0007175 consider: GO:0030293 [Term] id: GO:0005157 name: macrophage colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor." [GOC:ai] synonym: "macrophage colony stimulating factor receptor binding" EXACT [] synonym: "macrophage colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005158 name: insulin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the insulin receptor." [GOC:ai] synonym: "insulin receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding is_a: GO:0032403 ! protein complex binding [Term] id: GO:0005159 name: insulin-like growth factor receptor binding namespace: molecular_function alt_id: GO:0005067 def: "Interacting selectively and non-covalently with the insulin-like growth factor receptor." [GOC:jl] synonym: "IGF receptor binding" EXACT [] synonym: "insulin-like growth factor" NARROW [] synonym: "insulin-like growth factor receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005160 name: transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the transforming growth factor beta receptor." [GOC:ai] synonym: "activin" RELATED [] synonym: "inhibin" RELATED [] synonym: "TGF-beta receptor binding" EXACT [] synonym: "TGFbeta receptor binding" EXACT [] synonym: "transforming growth factor beta" NARROW [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor anchoring activity" RELATED [] synonym: "transforming growth factor beta receptor ligand" NARROW [] xref: Reactome:4078 "transforming growth factor beta receptor binding" is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005161 name: platelet-derived growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the platelet-derived growth factor receptor." [GOC:ai] synonym: "PDGF" NARROW [] synonym: "PDGF receptor binding" EXACT [] synonym: "PDGFR binding" EXACT [] synonym: "platelet-derived growth factor" NARROW [] synonym: "platelet-derived growth factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005163 name: nerve growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the nerve growth factor receptor." [GOC:ai, PMID:15654015] synonym: "nerve growth factor receptor ligand" NARROW [] synonym: "neurotrophin" NARROW [] synonym: "NGF receptor binding" EXACT [] is_a: GO:0005123 ! death receptor binding is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005164 name: tumor necrosis factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai] synonym: "TNF receptor binding" EXACT [] synonym: "tumor necrosis factor" NARROW [] synonym: "tumor necrosis factor receptor ligand" NARROW [] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005165 name: neurotrophin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotrophin receptor." [GOC:ai] synonym: "neurotrophin" NARROW [] synonym: "neurotrophin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005166 name: neurotrophin p75 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin p75 receptor." [GOC:ai] synonym: "neurotrophin p75 receptor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005167 name: neurotrophin TRK receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotrophin TRK receptor." [GOC:ai] synonym: "neurotrophin TRK receptor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005168 name: neurotrophin TRKA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKA receptor." [GOC:ai] synonym: "neurotrophin TRKA receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005169 name: neurotrophin TRKB receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKB receptor." [GOC:ai] synonym: "neurotrophin TRKB receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005170 name: neurotrophin TRKC receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKC receptor." [GOC:ai] synonym: "neurotrophin TRKC receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005171 name: hepatocyte growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the hepatocyte growth factor receptor." [GOC:ai] synonym: "hepatocyte growth factor" NARROW [] synonym: "hepatocyte growth factor receptor ligand" NARROW [] synonym: "HGF receptor binding" EXACT [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005172 name: vascular endothelial growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any vascular endothelial growth factor receptor." [GOC:ai] synonym: "vascular endothelial growth factor" NARROW [] synonym: "vascular endothelial growth factor receptor ligand" NARROW [] synonym: "VEGF receptor binding" EXACT [] synonym: "VEGFR binding" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005173 name: stem cell factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217] synonym: "KIT binding" NARROW [] synonym: "SCF" NARROW [] synonym: "SCFR binding" EXACT [] synonym: "stem cell factor" NARROW [] synonym: "stem cell factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005174 name: CD40 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005175 name: CD27 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005176 name: ErbB-2 class receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl] synonym: "ErbB-2 class receptor ligand" NARROW [] synonym: "HER2 receptor binding" EXACT [] synonym: "HER2 receptor ligand" NARROW [] synonym: "Neu receptor binding" EXACT [] synonym: "Neu receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005177 name: neuroligin namespace: molecular_function def: "OBSOLETE. A class of ligands for neurexins." [GOC:ai] is_obsolete: true consider: GO:0042043 [Term] id: GO:0005178 name: integrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an integrin." [GOC:ceb] synonym: "integrin ligand" NARROW [] is_a: GO:0005102 ! receptor binding is_a: GO:0032403 ! protein complex binding [Term] id: GO:0005179 name: hormone activity namespace: molecular_function def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "cAMP generating peptide activity" NARROW [] synonym: "glycopeptide hormone" NARROW [] synonym: "lipopeptide hormone" NARROW [] synonym: "peptide hormone" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005180 name: peptide hormone namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. is_obsolete: true consider: GO:0005179 [Term] id: GO:0005181 name: glycopeptide hormone namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. is_obsolete: true consider: GO:0005179 [Term] id: GO:0005182 name: lipopeptide hormone namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. is_obsolete: true consider: GO:0005179 [Term] id: GO:0005183 name: gonadotropin hormone-releasing hormone activity namespace: molecular_function def: "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary." [http://en.wikipedia.org/wiki/Gonadotropin-releasing_hormone, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11026571] synonym: "GnRH activity" EXACT [ISBN:0198506732] synonym: "LH/FSH-RF" EXACT [ISBN:0198506732] synonym: "LHRH activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone-releasing factor activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone-releasing hormone activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone/follicle-stimulating hormone releasing factor activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0005184 name: neuropeptide hormone activity namespace: molecular_function def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] synonym: "neurohormone" EXACT [] xref: Wikipedia:Neurohormone is_a: GO:0005179 ! hormone activity [Term] id: GO:0005185 name: neurohypophyseal hormone activity namespace: molecular_function def: "The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin." [GOC:mah, PMID:19243634] synonym: "neurohypophysial hormone activity" EXACT [GOC:mah] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0005186 name: pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0005102 ! receptor binding [Term] id: GO:0005187 name: storage protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular location rather than a function. is_obsolete: true replaced_by: GO:0045735 [Term] id: GO:0005188 name: larval serum protein (sensu Insecta) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "arylphorin" NARROW [] is_obsolete: true [Term] id: GO:0005189 name: milk protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005190 name: seminal fluid protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005191 name: acidic epididymal glycoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005192 name: urinary protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005193 name: major urinary protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005194 name: cell adhesion molecule activity namespace: molecular_function def: "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. is_obsolete: true consider: GO:0005102 consider: GO:0005515 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 [Term] id: GO:0005198 name: structural molecule activity namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0003674 ! molecular_function [Term] id: GO:0005199 name: structural constituent of cell wall namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] subset: gosubset_prok is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005200 name: structural constituent of cytoskeleton namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] subset: gosubset_prok is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005201 name: extracellular matrix structural constituent namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] subset: gosubset_prok synonym: "extracellular matrix glycoprotein" NARROW [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005202 name: collagen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0005581 [Term] id: GO:0005203 name: proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. is_obsolete: true [Term] id: GO:0005204 name: chondroitin sulfate proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "chondroitin sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005205 name: chondroitin sulfate/dermatan sulfate proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "chondroitin sulphate/dermatan sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005206 name: heparin sulfate proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "heparin sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005207 name: extracellular matrix glycoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes localization and modification rather than activity. is_obsolete: true consider: GO:0005201 [Term] id: GO:0005208 name: amyloid protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0005209 name: plasma protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005211 name: plasma glycoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005212 name: structural constituent of eye lens namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005213 name: structural constituent of chorion namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] synonym: "structural protein of chorion" NARROW [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005214 name: structural constituent of chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] is_a: GO:0042302 ! structural constituent of cuticle [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "small-molecule carrier or transporter" RELATED [] xref: Reactome:1391 "transporter activity" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005216 name: ion channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0022838 ! substrate-specific channel activity [Term] id: GO:0005217 name: intracellular ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005218 name: intracellular ligand-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0015278 ! calcium-release channel activity [Term] id: GO:0005219 name: ryanodine-sensitive calcium-release channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb] synonym: "caffeine-sensitive calcium-release channel" RELATED [] synonym: "ryanodine receptor" NARROW [] is_a: GO:0005218 ! intracellular ligand-gated calcium channel activity [Term] id: GO:0005220 name: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate has been bound by the channel complex or one of its constituent parts." [GOC:mah, PMID:8660280] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0008095 ! inositol-1,4,5-trisphosphate receptor activity is_a: GO:0015278 ! calcium-release channel activity [Term] id: GO:0005221 name: intracellular cyclic nucleotide activated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0005261 ! cation channel activity is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity [Term] id: GO:0005222 name: intracellular cAMP activated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT [] synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT [] synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT [] synonym: "intracellular cyclic AMP activated cation channel activity" EXACT [] is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: GO:0005223 name: intracellular cGMP activated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: GO:0005224 name: ATP-binding and phosphorylation-dependent chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0005254 ! chloride channel activity [Term] id: GO:0005225 name: volume-sensitive anion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:dph, GOC:tb] synonym: "volume-regulated channel" BROAD [] is_a: GO:0005253 ! anion channel activity [Term] id: GO:0005227 name: calcium activated cation channel activity namespace: molecular_function def: "Catalysis of the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] synonym: "intracellular calcium-activated potassium channel" NARROW [] synonym: "polycystin" NARROW [] is_a: GO:0005261 ! cation channel activity [Term] id: GO:0005228 name: intracellular sodium activated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0005229 name: intracellular calcium activated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] is_a: GO:0005254 ! chloride channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0005230 name: extracellular ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005231 name: excitatory extracellular ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels." [GOC:mah, ISBN:0323037070] subset: gosubset_prok xref: Reactome:4230 "excitatory extracellular ligand-gated ion channel activity" is_a: GO:0005230 ! extracellular ligand-gated ion channel activity [Term] id: GO:0005232 name: serotonin-activated cation-selective channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, and that is activated by serotonin." [GOC:mah] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'serotonin receptor activity ; GO:0004993'. synonym: "5-hydroxytryptamine-gated receptor-channel" EXACT [] xref: Reactome:13147 "serotonin-activated cation-selective channel activity" is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0005261 ! cation channel activity [Term] id: GO:0005234 name: extracellular-glutamate-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. subset: gosubset_prok is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity [Term] id: GO:0005237 name: inhibitory extracellular ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels." [GOC:mah, ISBN:0323037070] is_a: GO:0005230 ! extracellular ligand-gated ion channel activity [Term] id: GO:0005240 name: glycine receptor-associated protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not describe a molecular function. is_obsolete: true consider: GO:0005515 [Term] id: GO:0005241 name: inward rectifier channel namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. is_obsolete: true consider: GO:0005242 [Term] id: GO:0005242 name: inward rectifier potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398] subset: gosubset_prok synonym: "Kir channel activity" EXACT [GOC:cb] is_a: GO:0005249 ! voltage-gated potassium channel activity is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005243 name: gap junction channel activity namespace: molecular_function alt_id: GO:0015285 alt_id: GO:0015286 def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729] synonym: "connexin" RELATED [] synonym: "innexin" NARROW [] synonym: "innexin channel activity" EXACT [] synonym: "intercellular channel" BROAD [] xref: Reactome:13185 "gap junction channel activity" is_a: GO:0022829 ! wide pore channel activity [Term] id: GO:0005244 name: voltage-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "voltage gated ion channel activity" EXACT [] synonym: "voltage-dependent ion channel activity" EXACT [] is_a: GO:0005216 ! ion channel activity is_a: GO:0022832 ! voltage-gated channel activity [Term] id: GO:0005245 name: voltage-gated calcium channel activity namespace: molecular_function alt_id: GO:0010173 alt_id: GO:0015270 def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] synonym: "depolarization-activated calcium channel" BROAD [] synonym: "depolarization-activated voltage gated calcium channel activity" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT [] synonym: "dihydropyridine-sensitive calcium channel activity" NARROW [] synonym: "voltage gated calcium channel activity" EXACT [] synonym: "voltage-dependent calcium channel activity" EXACT [] synonym: "voltage-gated calcium ion channel activity" EXACT [] synonym: "voltage-sensitive calcium channel" EXACT [] xref: Reactome:13187 "voltage-gated calcium channel activity" is_a: GO:0005262 ! calcium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0005246 name: calcium channel regulator activity namespace: molecular_function def: "Modulates the activity of a calcium channel." [GOC:mah] is_a: GO:0016247 ! channel regulator activity [Term] id: GO:0005247 name: voltage-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "voltage gated chloride channel activity" EXACT [] synonym: "voltage-dependent chloride channel activity" EXACT [] is_a: GO:0005254 ! chloride channel activity is_a: GO:0008308 ! voltage-gated anion channel activity [Term] id: GO:0005248 name: voltage-gated sodium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated sodium channel activity" EXACT [] synonym: "voltage-dependent sodium channel activity" EXACT [] synonym: "voltage-gated sodium ion channel activity" EXACT [] synonym: "voltage-sensitive sodium channel" EXACT [] is_a: GO:0005272 ! sodium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0005249 name: voltage-gated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "voltage gated potassium channel activity" EXACT [] synonym: "voltage-dependent potassium channel activity" EXACT [] synonym: "voltage-gated potassium ion channel activity" EXACT [] synonym: "voltage-sensitive potassium channel" EXACT [] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0005250 name: A-type (transient outward) potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340] is_a: GO:0015271 ! outward rectifier potassium channel activity [Term] id: GO:0005251 name: delayed rectifier potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and activation is slow." [GOC:mah, PMID:11343411, PMID:2462513] is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0005252 name: open rectifier potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration." [GOC:mah, PMID:8917578] is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0005253 name: anion channel activity namespace: molecular_function def: "Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: Reactome:4246 "anion channel activity" is_a: GO:0005216 ! ion channel activity is_a: GO:0008509 ! anion transmembrane transporter activity [Term] id: GO:0005254 name: chloride channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: Reactome:4244 "chloride channel activity" is_a: GO:0005253 ! anion channel activity [Term] id: GO:0005260 name: channel-conductance-controlling ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels." [EC:3.6.3.49] synonym: "ATP phosphohydrolase (channel-conductance-controlling)" EXACT [EC:3.6.3.49] synonym: "cystic fibrosis transmembrane conductance regulator" NARROW [] synonym: "cystic-fibrosis membrane-conductance-regulating protein activity" NARROW [EC:3.6.3.49] xref: EC:3.6.3.49 xref: MetaCyc:3.6.3.49-RXN is_a: GO:0005254 ! chloride channel activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0005261 name: cation channel activity namespace: molecular_function alt_id: GO:0015281 alt_id: GO:0015338 def: "Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "cation diffusion facilitator activity" EXACT [] synonym: "nonselective cation channel activity" EXACT [] xref: Reactome:13089 "cation channel activity" is_a: GO:0005216 ! ion channel activity is_a: GO:0008324 ! cation transmembrane transporter activity [Term] id: GO:0005262 name: calcium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: Reactome:13088 "calcium channel activity" is_a: GO:0005261 ! cation channel activity [Term] id: GO:0005267 name: potassium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0005261 ! cation channel activity [Term] id: GO:0005272 name: sodium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005261 ! cation channel activity [Term] id: GO:0005274 name: allantoin uptake transmembrane transporter activity namespace: molecular_function alt_id: GO:0015206 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1] synonym: "allantoin permease activity" RELATED [] synonym: "allantoin/allantoate transporter" BROAD [] is_a: GO:0015391 ! nucleobase:cation symporter activity is_a: GO:0015563 ! uptake transmembrane transporter activity [Term] id: GO:0005275 name: amine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005279 def: "Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "amine/amide/polyamine channel activity" BROAD [] synonym: "amine/polyamine transmembrane transporter activity" EXACT [] synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] is_a: GO:0022804 ! active transmembrane transporter activity is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0005276 name: vesicular hydrogen:amino acid antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in)." [GOC:mah, Reactome:428625] synonym: "hydrogen:vesicular amine antiporter activity" EXACT [GOC:curators] xref: Reactome:13287 "vesicular hydrogen:amino acid antiporter activity" is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0015299 ! solute:hydrogen antiporter activity [Term] id: GO:0005277 name: acetylcholine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] xref: Reactome:13291 "acetylcholine transmembrane transporter activity" is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0005326 ! neurotransmitter transporter activity [Term] id: GO:0005278 name: acetylcholine:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13] synonym: "acetylcholine:proton antiporter activity" EXACT [] is_a: GO:0005277 ! acetylcholine transmembrane transporter activity is_a: GO:0015299 ! solute:hydrogen antiporter activity [Term] id: GO:0005280 name: hydrogen:amino acid symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai] subset: gosubset_prok synonym: "cation/amino acid symporter" BROAD [] is_a: GO:0005416 ! cation:amino acid symporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity [Term] id: GO:0005281 name: general amino acid permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "general amino acid transporter" BROAD [] is_obsolete: true replaced_by: GO:0015171 [Term] id: GO:0005283 name: sodium:amino acid symporter activity namespace: molecular_function alt_id: GO:0005284 alt_id: GO:0005285 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "insulin-activated sodium/amino acid transporter activity" NARROW [] synonym: "insulin-activated sodium:amino acid symporter activity" NARROW [] synonym: "insulin-activated sodium:amino acid transporter activity" NARROW [] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "sodium/amino acid transporter activity" BROAD [] synonym: "sodium/excitatory amino acid cotransporter activity" BROAD [] synonym: "sodium/excitatory amino acid symporter activity" EXACT [] synonym: "sodium:amino acid transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" RELATED [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005416 ! cation:amino acid symporter activity [Term] id: GO:0005287 name: high affinity basic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity basic amino acid transporter activity" BROAD [] is_a: GO:0015174 ! basic amino acid transmembrane transporter activity [Term] id: GO:0005289 name: high affinity arginine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arginine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity arginine transporter activity" BROAD [] is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity is_a: GO:0015181 ! arginine transmembrane transporter activity [Term] id: GO:0005290 name: L-histidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-histidine transporter activity" BROAD [] is_a: GO:0015174 ! basic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0005291 name: high affinity L-histidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity histidine permease activity" RELATED [] is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity is_a: GO:0005290 ! L-histidine transmembrane transporter activity [Term] id: GO:0005292 name: high affinity lysine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lysine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity lysine transporter activity" BROAD [] is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity is_a: GO:0015189 ! L-lysine transmembrane transporter activity [Term] id: GO:0005294 name: neutral L-amino acid secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] subset: gosubset_prok synonym: "neutral L-amino acid porter activity" RELATED [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005295 name: neutral amino acid:sodium symporter activity namespace: molecular_function alt_id: GO:0005282 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1] synonym: "neutral amino acid-sodium cotransporter" BROAD [] synonym: "sodium/neutral amino acid transporter" BROAD [] is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0005297 name: hydrogen:proline symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai] synonym: "hydrogen/proline transporter" BROAD [] is_a: GO:0005280 ! hydrogen:amino acid symporter activity is_a: GO:0015193 ! L-proline transmembrane transporter activity [Term] id: GO:0005298 name: proline:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1] subset: gosubset_prok synonym: "sodium/proline symporter activity" EXACT [] xref: Reactome:13406 "proline:sodium symporter activity" is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0015193 ! L-proline transmembrane transporter activity [Term] id: GO:0005300 name: high-affinity tryptophan transmembrane transporter activity namespace: molecular_function def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:mtg_transport, ISBN:0815340729] synonym: "high-affinity tryptophan transporter activity" BROAD [] is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity [Term] id: GO:0005301 name: valine/tyrosine/tryptophan permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "hydrogen/valine-tyrosine-tryptophan transporter" EXACT [] is_obsolete: true consider: GO:0005302 consider: GO:0005304 consider: GO:0015196 consider: GO:0022857 [Term] id: GO:0005302 name: L-tyrosine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015508 def: "Catalysis of the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-tyrosine permease activity" EXACT [] synonym: "L-tyrosine transporter activity" BROAD [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0005304 name: L-valine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "L-valine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0005307 name: choline:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5] synonym: "sodium/choline symporter activity" EXACT [] is_a: GO:0015220 ! choline transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005308 name: creatine transporter activity namespace: molecular_function def: "Enables the directed movement of creatine into, out of or within a cell, or between cells. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] is_a: GO:0051184 ! cofactor transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0005309 name: creatine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4] synonym: "sodium/chloride-dependent creatine transporter" BROAD [] xref: Reactome:14013 "creatine:sodium symporter activity" is_a: GO:0005308 ! creatine transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005310 name: dicarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0005312 alt_id: GO:0015365 def: "Catalysis of the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] subset: gosubset_prok synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] synonym: "dicarboxylate carrier" NARROW [] synonym: "dicarboxylic acid permease activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: Reactome:14021 "dicarboxylic acid transmembrane transporter activity" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0005311 name: sodium:dicarboxylate/tricarboxylate symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "sodium:dicarboxylate/tricarboxylate cotransporter activity" BROAD [] is_obsolete: true consider: GO:0005310 consider: GO:0005343 consider: GO:0015142 [Term] id: GO:0005313 name: L-glutamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-glutamate transporter activity" BROAD [] xref: Reactome:13352 "L-glutamate transmembrane transporter activity" is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0005314 name: high-affinity glutamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in)." [TC:2.A.3.10.5] synonym: "high-affinity glutamate transporter activity" BROAD [] xref: Reactome:13351 "high-affinity glutamate transmembrane transporter activity" is_a: GO:0005313 ! L-glutamate transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005315 name: inorganic phosphate transmembrane transporter activity namespace: molecular_function alt_id: GO:0005317 def: "Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] subset: gosubset_prok is_a: GO:0015114 ! phosphate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005316 name: high affinity inorganic phosphate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in)." [TC:2.A.20.2.2] synonym: "sodium/phosphate cotransporter activity" BROAD [] is_a: GO:0005436 ! sodium:phosphate symporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005318 name: phosphate:hydrogen symporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] synonym: "phosphate:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015317 [Term] id: GO:0005319 name: lipid transporter activity namespace: molecular_function def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] subset: gosubset_prok synonym: "apolipoprotein" RELATED [] synonym: "lipophorin" NARROW [] xref: Reactome:7042 "lipid transporter activity" is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0005320 name: apolipoprotein namespace: molecular_function alt_id: GO:0015907 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0005319 [Term] id: GO:0005321 name: high-density lipoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "HDL" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005322 name: low-density lipoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "LDL" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005323 name: very-low-density lipoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "VLDL" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005324 name: long-chain fatty acid transporter activity namespace: molecular_function def: "Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. Long-chain fatty acids have a chain length of greater than 12 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "plasma membrane long-chain fatty acid transporter" NARROW [] xref: Reactome:14049 "long-chain fatty acid transporter activity" is_a: GO:0015245 ! fatty acid transporter activity [Term] id: GO:0005325 name: peroxisomal fatty-acyl-CoA transporter activity namespace: molecular_function alt_id: GO:0008562 def: "Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes." [EC:3.6.3.47] synonym: "ATP phosphohydrolase (fatty-acyl-CoA-transporting)" EXACT [EC:3.6.3.47] synonym: "fatty-acyl-CoA-transporting ATPase" BROAD [] synonym: "peroxisomal fatty acyl CoA transporter activity" EXACT [GOC:curators] xref: EC:3.6.3.47 xref: Reactome:14052 "peroxisomal fatty-acyl-CoA transporter activity" is_a: GO:0005324 ! long-chain fatty acid transporter activity is_a: GO:0015607 ! fatty-acyl-CoA transporter activity [Term] id: GO:0005326 name: neurotransmitter transporter activity namespace: molecular_function def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "neurotransmitter transmembrane transporter activity" EXACT [GOC:mah] xref: Reactome:13292 "neurotransmitter transporter activity" is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0005328 name: neurotransmitter:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] subset: gosubset_prok synonym: "sodium/neurotransmitter symporter activity" EXACT [] is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005329 name: dopamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity [Term] id: GO:0005330 name: dopamine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in)." [TC:2.A.22.1.3] synonym: "sodium/dopamine symporter activity" EXACT [] is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0005329 ! dopamine transmembrane transporter activity [Term] id: GO:0005332 name: gamma-aminobutyric acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2] comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'. synonym: "4-aminobutanoate:sodium symporter activity" EXACT [] synonym: "4-aminobutyrate:sodium symporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" EXACT [] synonym: "GABA:sodium symporter activity" EXACT [] synonym: "sodium/chloride-dependent GABA transporter activity" BROAD [] xref: Reactome:14075 "gamma-aminobutyric acid:sodium symporter activity" is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0015185 ! L-gamma-aminobutyric acid transmembrane transporter activity [Term] id: GO:0005333 name: norepinephrine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of norepinephrine from one side of the membrane to the other. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "levarterenol transporter activity" EXACT [] synonym: "noradrenaline transporter activity" EXACT [] xref: Wikipedia:Norepinephrine_transporter is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity [Term] id: GO:0005334 name: norepinephrine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in)." [TC:2.A.22.1.2] synonym: "noradrenaline:sodium symporter activity" EXACT [] synonym: "sodium/norepinephrine symporter activity" EXACT [] xref: Reactome:14077 "norepinephrine:sodium symporter activity" is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0005333 ! norepinephrine transmembrane transporter activity [Term] id: GO:0005335 name: serotonin:sodium symporter activity namespace: molecular_function alt_id: GO:0005336 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) = serotonin(in) + Na+(in)." [TC:2.A.22.1.1] synonym: "sodium/serotonin symporter activity" EXACT [] is_a: GO:0005328 ! neurotransmitter:sodium symporter activity [Term] id: GO:0005337 name: nucleoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "intracellular nucleoside transmembrane transporter activity" NARROW [] xref: Reactome:14083 "nucleoside transmembrane transporter activity" is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: GO:0005338 name: nucleotide-sugar transmembrane transporter activity namespace: molecular_function alt_id: GO:0005339 def: "Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926] xref: Reactome:14086 "nucleotide-sugar transmembrane transporter activity" is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0005340 name: nucleotide-sulfate transmembrane transporter activity namespace: molecular_function alt_id: GO:0005341 def: "Catalysis of the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport] synonym: "nucleotide-sulphate transporter activity" EXACT [] is_a: GO:0015116 ! sulfate transmembrane transporter activity [Term] id: GO:0005342 name: organic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0005343 name: organic acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1] subset: gosubset_prok synonym: "sodium/chloride-dependent organic acid cotransporter activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005344 name: oxygen transporter activity namespace: molecular_function alt_id: GO:0015033 def: "Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai] subset: gosubset_prok synonym: "globin" NARROW [] synonym: "hemerythrin" NARROW [] synonym: "hemocyanin" NARROW [] synonym: "oxygen-carrying" NARROW [] is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0005345 name: purine base transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [CHEBI:26386, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleobase transmembrane transporter activity" EXACT [] synonym: "purine transmembrane transporter activity" RELATED [GOC:curators] is_a: GO:0015205 ! nucleobase transmembrane transporter activity [Term] id: GO:0005346 name: purine ribonucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity [Term] id: GO:0005347 name: ATP transmembrane transporter activity namespace: molecular_function alt_id: GO:0005348 def: "Catalysis of the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity [Term] id: GO:0005350 name: pyrimidine base transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of pyrimidine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [CHEBI:26432, GOC:ai] subset: gosubset_prok synonym: "pyrimidine nucleobase transmembrane transporter activity" EXACT [CHEBI:26432] synonym: "pyrimidine transmembrane transporter activity" RELATED [GOC:curators] is_a: GO:0015205 ! nucleobase transmembrane transporter activity [Term] id: GO:0005351 name: sugar:hydrogen symporter activity namespace: molecular_function alt_id: GO:0005403 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-] subset: gosubset_prok synonym: "cation/sugar symporter activity" BROAD [] synonym: "hydrogen:sugar symporter activity" EXACT [] synonym: "hydrogen:sugar transporter activity" BROAD [] synonym: "proton:sugar symporter activity" EXACT [] synonym: "sugar porter activity" RELATED [] synonym: "sugar transporter" BROAD [] synonym: "sugar:hydrogen ion symporter activity" EXACT [] is_a: GO:0005402 ! cation:sugar symporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity [Term] id: GO:0005352 name: alpha-glucoside:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11] synonym: "general alpha-glucoside transporter activity" BROAD [] synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT [] synonym: "general alpha-glucoside:proton symporter activity" EXACT [] is_a: GO:0005402 ! cation:sugar symporter activity is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity [Term] id: GO:0005353 name: fructose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015585 alt_id: GO:0019192 def: "Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "fructose permease activity" EXACT [] synonym: "fructose porter activity" EXACT [] xref: Reactome:7701 "fructose transmembrane transporter activity" is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0005354 name: galactose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of galactose from one side of the membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0005355 name: glucose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015579 def: "Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] synonym: "glucose permease activity" EXACT [] synonym: "lactose/glucose efflux transporter activity" NARROW [] xref: Reactome:14118 "glucose transmembrane transporter activity" is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0005356 name: hydrogen:glucose symporter activity namespace: molecular_function alt_id: GO:0005361 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "hydrogen:glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen/glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen:glucose symporter activity" NARROW [] synonym: "transepithelial hydrogen:glucose transporter activity" RELATED [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0009679 ! hexose:hydrogen symporter activity [Term] id: GO:0005357 name: constitutive hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "constitutive hydrogen/glucose transporter activity" BROAD [] synonym: "constitutive hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! hydrogen:glucose symporter activity [Term] id: GO:0005358 name: high-affinity hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity hydrogen/glucose transporter activity" BROAD [] synonym: "high-affinity hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! hydrogen:glucose symporter activity [Term] id: GO:0005359 name: low-affinity hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "low-affinity hydrogen/glucose transporter activity" BROAD [] synonym: "low-affinity hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! hydrogen:glucose symporter activity [Term] id: GO:0005360 name: insulin-responsive hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen/glucose transporter activity" RELATED [] is_a: GO:0005356 ! hydrogen:glucose symporter activity [Term] id: GO:0005362 name: low-affinity glucose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-] synonym: "low-affinity glucose-sodium cotransporter activity" BROAD [] xref: Reactome:14138 "low-affinity glucose:sodium symporter activity" is_a: GO:0005412 ! glucose:sodium symporter activity [Term] id: GO:0005363 name: maltose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015581 def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "maltose porter activity" EXACT [] is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0005364 name: maltose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10] synonym: "hydrogen/maltose transporter activity" BROAD [] synonym: "maltose permease" BROAD [] synonym: "maltose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0005363 ! maltose transmembrane transporter activity [Term] id: GO:0005365 name: myo-inositol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of myo-inositol from one side of the membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] subset: gosubset_prok synonym: "vitamin Bh transporter activity" EXACT [] is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0005366 name: myo-inositol:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8] synonym: "hydrogen/myo-inositol transporter activity" BROAD [] synonym: "myo-inositol:proton symporter activity" EXACT [] xref: Reactome:14152 "myo-inositol:hydrogen symporter activity" is_a: GO:0005365 ! myo-inositol transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity [Term] id: GO:0005367 name: myo-inositol:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-] synonym: "myo-inositol-sodium cotransporter activity" BROAD [] xref: Reactome:14154 "myo-inositol:sodium symporter activity" is_a: GO:0005365 ! myo-inositol transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005368 name: taurine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai] subset: gosubset_prok is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0005369 name: taurine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3] synonym: "sodium/chloride-dependent taurine transporter" BROAD [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005368 ! taurine transmembrane transporter activity [Term] id: GO:0005371 name: tricarboxylate secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0005370 def: "Catalysis of the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "tricarboxylate carrier activity" EXACT [] is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005372 name: water transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of water (H2O) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0005373 name: heavy metal ion porter activity namespace: molecular_function def: "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "metal ion transporter" BROAD [] is_obsolete: true consider: GO:0015291 consider: GO:0046873 [Term] id: GO:0005375 name: copper ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0005378 alt_id: GO:0005379 alt_id: GO:0005380 def: "Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "intracellular copper ion transporter" NARROW [] synonym: "plasma membrane copper transporter" NARROW [] xref: Reactome:7026 "copper ion transmembrane transporter activity" is_a: GO:0022890 ! inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0005376 name: plasma membrane copper transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0005375 consider: GO:0005886 [Term] id: GO:0005377 name: intracellular copper ion transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "intracellular copper transporter" EXACT [] is_obsolete: true replaced_by: GO:0005375 replaced_by: GO:0005622 [Term] id: GO:0005381 name: iron ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0005382 alt_id: GO:0016033 def: "Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "iron transporter activity" EXACT [] synonym: "multicopper ferroxidase iron transport mediator activity" RELATED [] synonym: "transmembrane iron ion permease activity" EXACT [] synonym: "transmembrane iron permease activity" EXACT [] synonym: "zinc, iron permease activity" RELATED [] xref: Reactome:10390 "iron ion transmembrane transporter activity" is_a: GO:0022890 ! inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0005384 name: manganese ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf] subset: gosubset_prok is_a: GO:0022890 ! inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0005385 name: zinc ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf] subset: gosubset_prok synonym: "cobalt, zinc uptake permease activity" RELATED [] synonym: "zinc, cadmium uptake permease activity" RELATED [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] synonym: "zinc, iron permease activity" NARROW [] xref: Reactome:14183 "zinc ion transmembrane transporter activity" is_a: GO:0046915 ! transition metal ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0005388 name: calcium-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] subset: gosubset_prok synonym: "ATP phosphohydrolase (Ca2+-transporting)" EXACT [EC:3.6.3.8] synonym: "Ca(2+)-transporting ATPase activity" EXACT [EC:3.6.3.8] synonym: "Ca2+-pumping ATPase activity" EXACT [EC:3.6.3.8] synonym: "Ca2+-transporting ATPase activity" EXACT [EC:3.6.3.8] synonym: "calcium ABC transporter" NARROW [] synonym: "calcium efflux ATPase" NARROW [] synonym: "calcium pump" BROAD [] synonym: "calcium transporting ATPase activity" EXACT [] synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:3.6.3.8] synonym: "plasma membrane Ca-ATPase" NARROW [EC:3.6.3.8] synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [EC:3.6.3.8] synonym: "sarcoplasmic reticulum ATPase" NARROW [] xref: EC:3.6.3.8 xref: MetaCyc:3.6.3.8-RXN xref: Reactome:14189 "calcium-transporting ATPase activity" is_a: GO:0015085 ! calcium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0005391 name: sodium:potassium-exchanging ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9] subset: gosubset_prok synonym: "(Na+ + K+)-activated ATPase activity" EXACT [EC:3.6.3.9] synonym: "(Na+ + K+)-ATPase activity" EXACT [EC:3.6.3.9] synonym: "ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [EC:3.6.3.9] synonym: "Na(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+,K+ pump" RELATED [EC:3.6.3.9] synonym: "Na+,K+-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+/K+-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na,K-activated ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na,K-pump" RELATED [EC:3.6.3.9] synonym: "sodium pump" BROAD [] synonym: "sodium/potassium-exchanging ATPase activity" EXACT [] synonym: "sodium/potassium-transporting ATPase activity" EXACT [EC:3.6.3.9] synonym: "sodium:potassium exchanging ATPase activity" EXACT [] xref: EC:3.6.3.9 xref: MetaCyc:3.6.3.9-RXN xref: Reactome:14207 "sodium:potassium-exchanging ATPase activity" is_a: GO:0008556 ! potassium-transporting ATPase activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity [Term] id: GO:0005395 name: eye pigment precursor transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1] is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0005396 name: transmembrane conductance regulator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong. is_obsolete: true consider: GO:0043267 [Term] id: GO:0005400 name: peroxisomal membrane transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0005215 consider: GO:0005777 [Term] id: GO:0005402 name: cation:sugar symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai] subset: gosubset_prok synonym: "cation/sugar symporter activity" EXACT [] synonym: "sugar:cation symporter activity" EXACT [] is_a: GO:0015294 ! solute:cation symporter activity is_a: GO:0051119 ! sugar transmembrane transporter activity [Term] id: GO:0005412 name: glucose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] synonym: "sodium/glucose symporter activity" EXACT [] xref: Reactome:14139 "glucose:sodium symporter activity" is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005415 name: nucleoside:sodium symporter activity namespace: molecular_function alt_id: GO:0008522 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "nucleoside-sodium cotransporter activity" BROAD [] synonym: "sodium-dependent nucleoside transporter activity" BROAD [] xref: Reactome:14944 "nucleoside:sodium symporter activity" is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005416 name: cation:amino acid symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai] subset: gosubset_prok synonym: "cation/amino acid symporter activity" EXACT [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0005427 name: proton-dependent oligopeptide secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544] subset: gosubset_prok synonym: "hydrogen/oligopeptide symporter" RELATED [] synonym: "proton-dependent oligopeptide transporter activity" EXACT [] is_a: GO:0015322 ! secondary active oligopeptide transmembrane transporter activity [Term] id: GO:0005429 name: chromaffin granule amine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of amines across chromaffin granule membranes." [GOC:mah] is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0005430 name: synaptic vesicle amine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of amines across synaptic vesicle membranes." [GOC:ai] is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0005432 name: calcium:sodium antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597] subset: gosubset_prok synonym: "mitochondrial sodium/calcium ion exchange" RELATED [] synonym: "sodium/calcium exchanger" EXACT [] synonym: "sodium:calcium exchange" RELATED [] xref: Reactome:14991 "calcium:sodium antiporter activity" is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015368 ! calcium:cation antiporter activity [Term] id: GO:0005436 name: sodium:phosphate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai] subset: gosubset_prok synonym: "sodium/phosphate symporter activity" EXACT [] is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015114 ! phosphate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0005451 name: monovalent cation:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai] subset: gosubset_prok synonym: "monovalent cation:proton antiporter activity" EXACT [GOC:mah] is_a: GO:0015299 ! solute:hydrogen antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0005452 name: inorganic anion exchanger activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah] xref: Reactome:15027 "inorganic anion exchanger activity" is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0005456 name: CMP-N-acetylneuraminate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a CMP-N-acetylneuraminate from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "CMP-sialic acid transmembrane transporter activity" BROAD [] xref: Reactome:15038 "CMP-N-acetylneuraminate transmembrane transporter activity" is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: GO:0005457 name: GDP-fucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:15041 "GDP-fucose transmembrane transporter activity" is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005458 name: GDP-mannose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a GDP-mannose from one side of the membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005459 name: UDP-galactose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:15045 "UDP-galactose transmembrane transporter activity" is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: GO:0005460 name: UDP-glucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-glucose from one side of the membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: GO:0005461 name: UDP-glucuronic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-glucuronic acid from one side of the membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:15054 "UDP-glucuronic acid transmembrane transporter activity" is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: GO:0005462 name: UDP-N-acetylglucosamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:15057 "UDP-N-acetylglucosamine transmembrane transporter activity" is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: GO:0005463 name: UDP-N-acetylgalactosamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: GO:0005464 name: UDP-xylose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] xref: Reactome:15062 "UDP-xylose transmembrane transporter activity" is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity [Term] id: GO:0005468 name: small-molecule carrier or transporter namespace: molecular_function alt_id: GO:0005453 alt_id: GO:0005454 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not provide a useful functional classification. is_obsolete: true consider: GO:0005215 [Term] id: GO:0005469 name: succinate:fumarate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1] is_a: GO:0015138 ! fumarate transmembrane transporter activity is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015297 ! antiporter activity [Term] id: GO:0005471 name: ATP:ADP antiporter activity namespace: molecular_function alt_id: GO:0005349 def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1] subset: gosubset_prok synonym: "adenine nucleotide translocase" EXACT [] synonym: "ADP/ATP translocase" EXACT [] synonym: "ATP/ADP exchange" EXACT [] synonym: "ATP/ADP exchanger" EXACT [] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0005472 name: FAD carrier activity namespace: molecular_function def: "Catalysis of the transfer of flavin adenine dinucleotide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mah] synonym: "flavin adenine dinucleotide carrier activity" EXACT [] synonym: "flavin-adenine dinucleotide carrier activity" EXACT [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005476 name: carnitine:acyl carnitine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458] synonym: "carnitine/acyl carnitine carrier activity" EXACT [] synonym: "carnitine:acyl carnitine carrier activity" EXACT [] synonym: "fatty acyl carnitine carrier" EXACT [] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0005477 name: pyruvate secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "pyruvate carrier activity" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0050833 ! pyruvate transmembrane transporter activity [Term] id: GO:0005479 name: vacuolar assembly namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true replaced_by: GO:0007033 [Term] id: GO:0005480 name: vesicle transport namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true replaced_by: GO:0016192 [Term] id: GO:0005481 name: vesicle fusion namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true consider: GO:0006906 consider: GO:0007086 consider: GO:0016189 consider: GO:0016192 consider: GO:0019817 [Term] id: GO:0005482 name: vesicle targeting namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true consider: GO:0006903 consider: GO:0016080 [Term] id: GO:0005483 name: soluble NSF attachment protein activity namespace: molecular_function def: "Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857] synonym: "SNAP" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005484 name: SNAP receptor activity namespace: molecular_function alt_id: GO:0005485 alt_id: GO:0005486 def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] synonym: "Q-SNARE activity" NARROW [] synonym: "R-SNARE activity" NARROW [] synonym: "SNAP-25" NARROW [] synonym: "SNARE" EXACT [] synonym: "t-SNARE activity" NARROW [] synonym: "v-SNARE activity" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005487 name: nucleocytoplasmic transporter activity namespace: molecular_function def: "Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai] xref: Reactome:15116 "nucleocytoplasmic transporter activity" is_a: GO:0005215 ! transporter activity [Term] id: GO:0005488 name: binding namespace: molecular_function def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "ligand" NARROW [] xref: Wikipedia:Binding_(molecular) is_a: GO:0003674 ! molecular_function [Term] id: GO:0005489 name: electron transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai] comment: This term was made obsolete because the activity described by the definition does not exist. synonym: "class I cytochrome c" RELATED [] synonym: "class II cytochrome c" RELATED [] synonym: "class IIa cytochrome c" RELATED [] synonym: "class IIb cytochrome c" RELATED [] synonym: "class III cytochrome c" RELATED [] synonym: "class IV cytochrome c" RELATED [] synonym: "cytochrome b" RELATED [] synonym: "cytochrome b5" RELATED [] synonym: "cytochrome c3 (tetraheme)" RELATED [] synonym: "cytochrome c554" RELATED [] synonym: "cytochrome c7 (triheme)" RELATED [] synonym: "cytochrome d" RELATED [] synonym: "diheme class I cytochrome c" RELATED [] synonym: "electron transfer carrier" RELATED [] synonym: "flavin-containing electron transporter" RELATED [] synonym: "flavodoxin" RELATED [] synonym: "high-molecular-weight cytochrome c (hexadecaheme)" RELATED [] synonym: "monoheme class I cytochrome c" RELATED [] synonym: "nonaheme cytochrome c" RELATED [] synonym: "respiratory chain cytochrome b6" RELATED [] synonym: "Rieske iron-sulfur protein" RELATED [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0005490 name: cytochrome P450 namespace: molecular_function def: "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684] comment: This term was made obsolete because its definition was changed and because it represents a gene product. is_obsolete: true [Term] id: GO:0005496 name: steroid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0008289 ! lipid binding [Term] id: GO:0005497 name: androgen binding namespace: molecular_function def: "Interacting selectively and non-covalently with any androgen, male sex hormones." [CHEBI:50113, GOC:jl] is_a: GO:0005496 ! steroid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0005499 name: vitamin D binding namespace: molecular_function def: "Interacting selectively and non-covalently with vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309] synonym: "calciferol binding" NARROW [] synonym: "cholecalciferol binding" NARROW [] synonym: "ergocalciferol binding" NARROW [] is_a: GO:0005496 ! steroid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0005500 name: juvenile hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0005501 name: retinoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0019840 ! isoprenoid binding [Term] id: GO:0005502 name: 11-cis retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [CHEBI:16066] synonym: "11-cis retinaldehyde binding" EXACT [] synonym: "11-cis-retinal binding" NARROW [CHEBI:16066] synonym: "vitamin A binding" BROAD [] is_a: GO:0016918 ! retinal binding [Term] id: GO:0005503 name: all-trans retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [CHEBI:17898, GOC:curators] synonym: "all-trans retinaldehyde binding" EXACT [] synonym: "trans retinal binding" EXACT [] synonym: "visual yellow binding" EXACT [] synonym: "vitamin A binding" BROAD [] synonym: "xanthopsin" RELATED [] is_a: GO:0016918 ! retinal binding [Term] id: GO:0005504 name: fatty acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008289 ! lipid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0005505 name: heavy metal binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0046872 [Term] id: GO:0005506 name: iron ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] subset: gosubset_prok synonym: "iron binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0005507 name: copper ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] subset: gosubset_prok synonym: "copper binding" EXACT [] synonym: "copper/cadmium binding" BROAD [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0005508 name: copper/cadmium binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a composite function. is_obsolete: true consider: GO:0005507 consider: GO:0046870 [Term] id: GO:0005509 name: calcium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] subset: gosubset_prok synonym: "calcium ion storage activity" RELATED [] xref: Reactome:15962 "calcium ion binding" is_a: GO:0046872 ! metal ion binding [Term] id: GO:0005513 name: detection of calcium ion namespace: biological_process def: "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg] synonym: "Ca2+ ion detection" EXACT [] synonym: "calcium ion detection" EXACT [] synonym: "calcium ion sensing" EXACT [] synonym: "detection of Ca2+ ion" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051592 ! response to calcium ion [Term] id: GO:0005514 name: calcium ion storage activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0005509 replaced_by: GO:0051208 [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0045308 def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED [] synonym: "protein amino acid binding" EXACT [] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein folding chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "protein tagging activity" RELATED [] xref: Reactome:6125 "protein binding" is_a: GO:0005488 ! binding [Term] id: GO:0005516 name: calmodulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] subset: gosubset_prok is_a: GO:0005515 ! protein binding [Term] id: GO:0005517 name: calmodulin inhibitor activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:tb] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'calmodulin activity'. is_obsolete: true consider: GO:0005516 [Term] id: GO:0005518 name: collagen binding namespace: molecular_function def: "Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005515 ! protein binding [Term] id: GO:0005519 name: cytoskeletal regulatory protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0005520 name: insulin-like growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "IGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0005521 name: lamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "lamin/chromatin binding" BROAD [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005522 name: profilin binding namespace: molecular_function def: "Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0005515 ! protein binding [Term] id: GO:0005523 name: tropomyosin binding namespace: molecular_function def: "Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [GOC:curators, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0005524 name: ATP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:1403 "ATP binding" is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding [Term] id: GO:0005525 name: GTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] subset: gosubset_prok xref: Reactome:12514 "GTP binding" is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding [Term] id: GO:0005527 name: macrolide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008144 ! drug binding [Term] id: GO:0005528 name: FK506 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the immunosuppressant FK506." [GOC:jl] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED [] is_a: GO:0005527 ! macrolide binding [Term] id: GO:0005529 name: sugar binding namespace: molecular_function def: "Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0005530 name: lectin namespace: molecular_function def: "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [GOC:curators] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0005529 consider: GO:0007157 [Term] id: GO:0005531 name: galactose binding lectin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0005534 consider: GO:0007157 [Term] id: GO:0005532 name: mannose binding lectin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "mannose receptor" RELATED [] is_obsolete: true consider: GO:0005537 consider: GO:0007157 [Term] id: GO:0005533 name: N-acetylgalactosamine lectin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0007157 consider: GO:0046871 [Term] id: GO:0005534 name: galactose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [CHEBI:28260, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactose binding lectin" RELATED [] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005536 name: glucose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of glucose." [CHEBI:17234, GOC:jl] subset: gosubset_prok is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005537 name: mannose binding namespace: molecular_function def: "Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [CHEBI:37684, GOC:jl, ISBN:0192800981] subset: gosubset_prok synonym: "mannose binding lectin" RELATED [] xref: Reactome:16175 "mannose binding" is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005539 name: glycosaminoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0005540 name: hyaluronic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [CHEBI:16336, GOC:jl] synonym: "hyaluronan binding" EXACT [] is_a: GO:0005539 ! glycosaminoglycan binding [Term] id: GO:0005541 name: acyl-CoA or acyl binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it was replaced by more appropriate terms. is_obsolete: true consider: GO:0000035 consider: GO:0000062 [Term] id: GO:0005542 name: folic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "folate binding" EXACT [] synonym: "vitamin B9 binding" EXACT [] synonym: "vitamin M binding" EXACT [] is_a: GO:0016597 ! amino acid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0005543 name: phospholipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008289 ! lipid binding [Term] id: GO:0005544 name: calcium-dependent phospholipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] subset: gosubset_prok is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0005545 name: 1-phosphatidylinositol binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0005546 name: phosphatidylinositol-4,5-bisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl] synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding" EXACT [CHEBI:18348] synonym: "phosphatidylinositol 4,5-bisphosphate binding" EXACT [GOC:ebc] synonym: "PIP2 binding" BROAD [CHEBI:18348] synonym: "PtdIns(4,5)P2 binding" EXACT [GOC:bf] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0005547 name: phosphatidylinositol-3,4,5-trisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl] synonym: "PIP3 binding" EXACT [GOC:bf] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0005548 name: phospholipid transporter activity namespace: molecular_function alt_id: GO:0008497 def: "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:7040 "phospholipid transporter activity" is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0005549 name: odorant binding namespace: molecular_function def: "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0005550 name: pheromone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] is_a: GO:0005549 ! odorant binding [Term] id: GO:0005551 name: ubiquitin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0016567 consider: GO:0031386 [Term] id: GO:0005552 name: polyubiquitin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0000209 [Term] id: GO:0005553 name: ubiquitin-ribosomal protein fusion protein namespace: molecular_function def: "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it describes a gene product. is_obsolete: true [Term] id: GO:0005555 name: blood group antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true [Term] id: GO:0005557 name: lymphocyte antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true [Term] id: GO:0005558 name: minor histocompatibility antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true [Term] id: GO:0005559 name: ribozyme namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005561 name: nucleic acid namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005562 name: RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005563 name: transfer RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030533 [Term] id: GO:0005564 name: cytosolic tRNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005565 name: mitochondrial tRNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005566 name: ribosomal RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0003735 consider: GO:0005840 [Term] id: GO:0005567 name: cytosolic ribosomal RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005568 name: mitochondrial rRNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005569 name: small nucleolar RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents gene products. is_obsolete: true consider: GO:0030555 [Term] id: GO:0005570 name: small nuclear RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents gene products. is_obsolete: true consider: GO:0000375 consider: GO:0017069 [Term] id: GO:0005571 name: untranslated RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005572 name: RNA polymerase II transcribed untranslated RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005573 name: telomerase RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0000332 [Term] id: GO:0005574 name: DNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "cellular component" EXACT [] synonym: "cellular component unknown" NARROW [] xref: NIF_Subcellular:sao1337158144 disjoint_from: GO:0003674 ! molecular_function [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not uniformly attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0005575 ! cellular_component [Term] id: GO:0005577 name: fibrinogen complex namespace: cellular_component def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] synonym: "fibrinogen" EXACT [] synonym: "fibrinogen alpha chain" NARROW [] synonym: "fibrinogen beta chain" NARROW [] synonym: "fibrinogen gamma chain" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005578 name: proteinaceous extracellular matrix namespace: cellular_component def: "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] subset: goslim_generic subset: goslim_plant is_a: GO:0031012 ! extracellular matrix [Term] id: GO:0005579 name: membrane attack complex namespace: cellular_component def: "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"] synonym: "MAC" EXACT [] synonym: "membrane attack complex protein alphaM chain" NARROW [] synonym: "membrane attack complex protein beta2 chain" NARROW [] synonym: "TCC" EXACT [] synonym: "terminal complement complex" EXACT [] xref: Wikipedia:Complement_membrane_attack_complex is_a: GO:0044459 ! plasma membrane part is_a: GO:0046930 ! pore complex relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005580 name: membrane attack complex protein alphaM chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005579 [Term] id: GO:0005581 name: collagen namespace: cellular_component def: "Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976] synonym: "other collagen" RELATED [] xref: Wikipedia:Collagen is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0005582 name: collagen type XV namespace: cellular_component def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes." [PMID:11158616, PMID:11937714] is_a: GO:0005581 ! collagen [Term] id: GO:0005583 name: fibrillar collagen namespace: cellular_component def: "Any collagen polymer in which collagen triple helices associate to form fibrils." [GOC:mah, ISBN:0721639976] is_a: GO:0005581 ! collagen [Term] id: GO:0005584 name: collagen type I namespace: cellular_component def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [GOC:mah, GOC:sl, ISBN:0721639976] xref: Wikipedia:Collagen_type_I is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005585 name: collagen type II namespace: cellular_component def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: Wikipedia:Collagen_type_II is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005586 name: collagen type III namespace: cellular_component def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005587 name: collagen type IV namespace: cellular_component def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes." [ISBN:0721639976] xref: Wikipedia:Collagen_type_IV is_a: GO:0030935 ! sheet-forming collagen relationship: part_of GO:0005604 ! basement membrane [Term] id: GO:0005588 name: collagen type V namespace: cellular_component def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005589 name: collagen type VI namespace: cellular_component def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976] is_a: GO:0030934 ! anchoring collagen [Term] id: GO:0005590 name: collagen type VII namespace: cellular_component def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue." [ISBN:0721639976] is_a: GO:0030934 ! anchoring collagen [Term] id: GO:0005591 name: collagen type VIII namespace: cellular_component def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976] is_a: GO:0005598 ! short-chain collagen [Term] id: GO:0005592 name: collagen type XI namespace: cellular_component def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005593 name: FACIT collagen namespace: cellular_component def: "Any collagen polymer associated with collagen fibrils and in which the collagen monomers contain two or more relatively short triple-helical domains connected by non-triple-helical sequences; the acronym FACIT stands for fibril-associated collagen with interrupted triple helix." [ISBN:0198599587] xref: Wikipedia:FACIT_collagen is_a: GO:0030934 ! anchoring collagen [Term] id: GO:0005594 name: collagen type IX namespace: cellular_component def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen [Term] id: GO:0005595 name: collagen type XII namespace: cellular_component def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen [Term] id: GO:0005596 name: collagen type XIV namespace: cellular_component def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen [Term] id: GO:0005597 name: collagen type XVI namespace: cellular_component def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140] is_a: GO:0005593 ! FACIT collagen [Term] id: GO:0005598 name: short-chain collagen namespace: cellular_component def: "Any assembly of collagen in which the collagen chains are relatively short compared to the fibrillar collagens." [ISBN:0198599587] is_a: GO:0030935 ! sheet-forming collagen [Term] id: GO:0005599 name: collagen type X namespace: cellular_component def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices may form nets." [ISBN:0721639976] is_a: GO:0005598 ! short-chain collagen [Term] id: GO:0005600 name: collagen type XIII namespace: cellular_component def: "A collagen homotrimer of alpha1(XIII) chains; type X collagen triple helices span lipid bilayer membranes." [ISBN:0721639976] is_a: GO:0030936 ! transmembrane collagen [Term] id: GO:0005601 name: classical-complement-pathway C3/C5 convertase complex namespace: cellular_component def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005602 name: complement component C1 complex namespace: cellular_component def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "complement component C1q complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005603 name: complement component C2 complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entity corresponding to "complement C2 complex". is_obsolete: true [Term] id: GO:0005604 name: basement membrane namespace: cellular_component def: "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684] comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. xref: Wikipedia:Basement_membrane is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0005605 name: basal lamina namespace: cellular_component def: "A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684] synonym: "basement lamina" EXACT [] xref: NIF_Subcellular:sao1397492660 xref: Wikipedia:Basal_lamina is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005604 ! basement membrane [Term] id: GO:0005606 name: laminin-1 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005607 name: laminin-2 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0005608 name: laminin-3 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005609 name: laminin-4 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005610 name: laminin-5 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005611 name: laminin-6 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005612 name: laminin-7 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005613 name: laminin receptor protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family. is_obsolete: true consider: GO:0008305 [Term] id: GO:0005614 name: interstitial matrix namespace: cellular_component def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001] is_a: GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0005615 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_generic subset: goslim_plant synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0044421 ! extracellular region part [Term] id: GO:0005616 name: larval serum protein complex namespace: cellular_component def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005617 name: larval serum protein-1 namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "LSP1" EXACT [] is_obsolete: true [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cell_wall is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0005619 name: ascospore wall namespace: cellular_component def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568] synonym: "fungal-type spore wall" BROAD [GOC:mah] is_a: GO:0009277 ! fungal-type cell wall is_a: GO:0031160 ! spore wall [Term] id: GO:0005621 name: cellular bud scar namespace: cellular_component def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009277 ! fungal-type cell wall [Term] id: GO:0005622 name: intracellular namespace: cellular_component def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "internal to cell" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0044464 ! cell part [Term] id: GO:0005623 name: cell namespace: cellular_component def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: NIF_Subcellular:sao1813327414 xref: Wikipedia:Cell_(biology) is_a: GO:0005575 ! cellular_component [Term] id: GO:0005624 name: membrane fraction namespace: cellular_component def: "That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: goslim_candida subset: goslim_yeast subset: gosubset_prok is_a: GO:0005626 ! insoluble fraction [Term] id: GO:0005625 name: soluble fraction namespace: cellular_component def: "That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. synonym: "soluble" BROAD [] is_a: GO:0000267 ! cell fraction [Term] id: GO:0005626 name: insoluble fraction namespace: cellular_component def: "That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: gosubset_prok synonym: "particle-bound" RELATED [] is_a: GO:0000267 ! cell fraction [Term] id: GO:0005627 name: ascus namespace: cellular_component def: "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684] comment: This term was made obsolete because it is a type of cell rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'. is_obsolete: true [Term] id: GO:0005628 name: prospore membrane namespace: cellular_component def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649] subset: gosubset_prok synonym: "ascospore-type prospore membrane" EXACT [GOC:mah] synonym: "forespore membrane" RELATED [] synonym: "FSM" EXACT [] is_a: GO:0016020 ! membrane relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0005630 name: dityrosine layer of spore wall namespace: cellular_component def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005631 name: chitosan layer of spore wall namespace: cellular_component def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005632 name: inner layer of spore wall namespace: cellular_component def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005633 name: ascus lipid particle namespace: cellular_component def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293] synonym: "ascus lipid droplet" EXACT [GOC:curators] is_a: GO:0005811 ! lipid particle [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope is_a: GO:0044428 ! nuclear part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005637 name: nuclear inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] synonym: "inner envelope" BROAD [] xref: NIF_Subcellular:sao1612527463 is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031965 ! nuclear membrane [Term] id: GO:0005638 name: lamin filament namespace: cellular_component def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684] synonym: "type V intermediate filament" EXACT [] is_a: GO:0005882 ! intermediate filament is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005652 ! nuclear lamina [Term] id: GO:0005639 name: integral to nuclear inner membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] is_a: GO:0031229 ! intrinsic to nuclear inner membrane is_a: GO:0031301 ! integral to organelle membrane [Term] id: GO:0005640 name: nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] synonym: "outer envelope" BROAD [] synonym: "perinuclear membrane" EXACT [] xref: NIF_Subcellular:sao1617136075 is_a: GO:0031965 ! nuclear membrane is_a: GO:0031968 ! organelle outer membrane is_a: GO:0044425 ! membrane part relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005641 name: nuclear envelope lumen namespace: cellular_component alt_id: GO:0005653 def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai] comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. synonym: "nuclear intermembrane space" EXACT [] synonym: "nuclear membrane lumen" RELATED [] synonym: "perinuclear space" EXACT [] is_a: GO:0031970 ! organelle envelope lumen is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0005642 name: annulate lamellae namespace: cellular_component def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728] is_a: GO:0044425 ! membrane part relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005643 name: nuclear pore namespace: cellular_component alt_id: GO:0005644 def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] subset: goslim_pir synonym: "NPC" EXACT [] synonym: "nuclear pore complex" EXACT [] synonym: "nuclear pore membrane protein" NARROW [] xref: NIF_Subcellular:sao220861693 xref: Wikipedia:Nuclear_pore is_a: GO:0044428 ! nuclear part is_a: GO:0046930 ! pore complex relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0005645 name: RAN-binding protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0008536 consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005646 name: importin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005647 name: importin, alpha-subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin-alpha" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005648 name: importin, beta-subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin-beta1" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005649 name: transportin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin-beta2" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005650 name: importin, alpha-subunit transport factor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "CAS" RELATED [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005651 name: exportin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005652 name: nuclear lamina namespace: cellular_component def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] xref: NIF_Subcellular:sao1455996588 xref: Wikipedia:Nuclear_lamina is_a: GO:0044428 ! nuclear part relationship: part_of GO:0034399 ! nuclear periphery [Term] id: GO:0005654 name: nucleoplasm namespace: cellular_component def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao661522542 xref: Wikipedia:Nucleoplasm is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005655 name: nucleolar ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] synonym: "nucleolar RNase P complex" EXACT [] is_a: GO:0030681 ! multimeric ribonuclease P complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0005656 name: pre-replicative complex namespace: cellular_component def: "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894] synonym: "pre-RC" EXACT [] is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0005657 name: replication fork namespace: cellular_component def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "replication focus" RELATED [] xref: Wikipedia:Replication_fork is_a: GO:0044427 ! chromosomal part [Term] id: GO:0005658 name: alpha DNA polymerase:primase complex namespace: cellular_component def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402] synonym: "DNA polymerase alpha:primase complex" EXACT [] synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT [] synonym: "pol-prim" RELATED [] synonym: "primosome" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0005660 name: delta-DNA polymerase cofactor complex namespace: cellular_component def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl] comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature. synonym: "delta DNA polymerase cofactor complex" EXACT [] is_obsolete: true replaced_by: GO:0005663 replaced_by: GO:0043626 [Term] id: GO:0005662 name: DNA replication factor A complex namespace: cellular_component def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] synonym: "replication protein A" EXACT [] synonym: "RPA" EXACT [] synonym: "single-stranded DNA-binding protein complex" RELATED [] synonym: "SSB" RELATED [] xref: Wikipedia:Replication_protein_A is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0005663 name: DNA replication factor C complex namespace: cellular_component def: "A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520] subset: goslim_pir subset: gosubset_prok synonym: "activator 1 complex" EXACT [] synonym: "RFC complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005657 ! replication fork [Term] id: GO:0005664 name: nuclear origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] synonym: "eukaryotic ORC" EXACT [] synonym: "nuclear ORC" EXACT [] is_a: GO:0000808 ! origin recognition complex is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0005665 name: DNA-directed RNA polymerase II, core complex namespace: cellular_component def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "RNA polymerase II complex" BROAD [] synonym: "RNAP II complex" BROAD [] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005666 name: DNA-directed RNA polymerase III complex namespace: cellular_component def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase III activity" RELATED [] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0005667 name: transcription factor complex namespace: cellular_component def: "A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0005668 name: RNA polymerase transcription factor SL1 complex namespace: cellular_component def: "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48." [PMID:15691654] synonym: "selectivity factor SL1 complex" EXACT [GOC:mah] synonym: "TIF-IB" EXACT [CORUM:480, PMID:15691654] is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0005669 name: transcription factor TFIID complex namespace: cellular_component def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005670 name: transcription-activating factor, 30kD namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005669 [Term] id: GO:0005671 name: Ada2/Gcn5/Ada3 transcription activator complex namespace: cellular_component def: "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607] synonym: "Ada Two-A containing complex" EXACT [GOC:rl, PMID:18838386] synonym: "ATAC complex" EXACT [GOC:rl, PMID:18838386] is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0005672 name: transcription factor TFIIA complex namespace: cellular_component def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005673 name: transcription factor TFIIE complex namespace: cellular_component def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005674 name: transcription factor TFIIF complex namespace: cellular_component def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005675 name: holo TFIIH complex namespace: cellular_component def: "A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of ERCC2, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005677 name: chromatin silencing complex namespace: cellular_component def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0005678 name: chromatin assembly complex namespace: cellular_component def: "Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah] synonym: "nucleosome assembly complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0005680 name: anaphase-promoting complex namespace: cellular_component def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein. synonym: "anaphase promoting complex" EXACT [] synonym: "APC" BROAD [] synonym: "cyclosome" EXACT [] xref: Wikipedia:Anaphase-promoting_complex is_a: GO:0000152 ! nuclear ubiquitin ligase complex is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0005681 name: spliceosomal complex namespace: cellular_component def: "Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron." [GOC:mah, ISBN:0198547684, PMID:19239890] subset: goslim_pir synonym: "spliceosome complex" EXACT [] xref: Wikipedia:Spliceosome is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0005682 name: U5 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah] synonym: "snRNP U5" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005683 name: U7 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004] synonym: "snRNP U7" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005684 name: U2-type spliceosomal complex namespace: cellular_component def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] synonym: "GT-AG spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major (U2-type) spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "major spliceosomal complex" EXACT [GOC:krc, GOC:mah] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0005685 name: U1 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah] synonym: "snRNP U1" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005686 name: U2 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah] synonym: "17S U2 snRNP" NARROW [] synonym: "snRNP U2" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005687 name: U4 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U4." [GOC:krc, GOC:mah] synonym: "snRNP U4" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005688 name: U6 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah] synonym: "snRNP U6" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005689 name: U12-type spliceosomal complex namespace: cellular_component def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955] synonym: "AT-AC spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "minor (U12-type) spliceosomal complex" EXACT [GOC:mah] synonym: "minor spliceosomal complex" EXACT [GOC:krc, GOC:mah] xref: Wikipedia:Minor_spliceosome is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0005690 name: U4atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U4atac." [GOC:krc, GOC:mah] synonym: "snRNP U4atac" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005691 name: U6atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U6atac." [GOC:krc, GOC:mah] synonym: "snRNP U6atac" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005692 name: U11 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U11." [GOC:krc, GOC:mah] synonym: "12S U11 snRNP" NARROW [] synonym: "snRNP U11" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005693 name: U12 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U12." [GOC:krc, GOC:mah] synonym: "snRNP U12" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005695 name: chromatid namespace: cellular_component def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions. is_obsolete: true consider: GO:0000793 consider: GO:0000794 consider: GO:0005694 [Term] id: GO:0005696 name: telomere namespace: cellular_component def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11352055] comment: This term was made obsolete because the definition was too sequence oriented and too restrictive. is_obsolete: true consider: GO:0000781 consider: GO:0000782 [Term] id: GO:0005697 name: telomerase holoenzyme complex namespace: cellular_component def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619] subset: goslim_pir is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0005698 name: centromere namespace: cellular_component def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it is a genetically defined region and not a specific subcellular localization. is_obsolete: true consider: GO:0000775 [Term] id: GO:0005700 name: polytene chromosome namespace: cellular_component def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Polytene_chromosome is_a: GO:0005694 ! chromosome [Term] id: GO:0005701 name: polytene chromosome chromocenter namespace: cellular_component def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome chromocentre" EXACT [] is_a: GO:0010369 ! chromocenter relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005702 name: polytene chromosome weak point namespace: cellular_component def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012] synonym: "constriction" BROAD [] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005703 name: polytene chromosome puff namespace: cellular_component def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005704 name: polytene chromosome band namespace: cellular_component def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005705 name: polytene chromosome interband namespace: cellular_component def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005706 name: polytene chromosome ectopic fiber namespace: cellular_component def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome ectopic fibre" EXACT [] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005707 name: interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0005694 [Term] id: GO:0005708 name: mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai] comment: This term was made obsolete because it is based on a process. is_obsolete: true consider: GO:0000793 consider: GO:0000794 [Term] id: GO:0005709 name: prophase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0005694 [Term] id: GO:0005710 name: metaphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000793 consider: GO:0000794 [Term] id: GO:0005711 name: meiotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai] comment: This term was made obsolete because it is based on a process. is_obsolete: true consider: GO:0000794 [Term] id: GO:0005712 name: chiasma namespace: cellular_component def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Chiasma_(genetics) is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0005713 name: recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0005714 name: early recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh] is_a: GO:0005713 ! recombination nodule [Term] id: GO:0005715 name: late recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh] is_a: GO:0005713 ! recombination nodule [Term] id: GO:0005719 name: nuclear euchromatin namespace: cellular_component def: "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000791 ! euchromatin [Term] id: GO:0005720 name: nuclear heterochromatin namespace: cellular_component def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000792 ! heterochromatin [Term] id: GO:0005721 name: centromeric heterochromatin namespace: cellular_component def: "A region of heterochromatin located near the centromere of a chromosome." [PMID:12019236] synonym: "centric heterochromatin" EXACT [] is_a: GO:0000792 ! heterochromatin relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0005722 name: beta-heterochromatin namespace: cellular_component def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678] is_a: GO:0005721 ! centromeric heterochromatin relationship: part_of GO:0005701 ! polytene chromosome chromocenter [Term] id: GO:0005723 name: alpha-heterochromatin namespace: cellular_component def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678] is_a: GO:0005721 ! centromeric heterochromatin relationship: part_of GO:0005701 ! polytene chromosome chromocenter [Term] id: GO:0005724 name: nuclear telomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai] is_a: GO:0005720 ! nuclear heterochromatin is_a: GO:0031933 ! telomeric heterochromatin relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region [Term] id: GO:0005725 name: intercalary heterochromatin namespace: cellular_component def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] is_a: GO:0005720 ! nuclear heterochromatin [Term] id: GO:0005726 name: perichromatin fibrils namespace: cellular_component def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0005727 name: extrachromosomal circular DNA namespace: cellular_component def: "Circular DNA structures that are not part of a chromosome." [GOC:ai] subset: gosubset_prok is_a: GO:0044424 ! intracellular part relationship: part_of GO:0046821 ! extrachromosomal DNA [Term] id: GO:0005728 name: extrachromosomal rDNA circle namespace: cellular_component def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934] synonym: "extrachromosomal ribosomal DNA circle" EXACT [] is_a: GO:0005727 ! extrachromosomal circular DNA [Term] id: GO:0005729 name: 2-micrometer circle DNA namespace: cellular_component def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320] is_a: GO:0005727 ! extrachromosomal circular DNA [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005731 name: nucleolus organizer region namespace: cellular_component def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406] synonym: "NOR" EXACT [] synonym: "nucleolus organiser region" EXACT [] synonym: "nucleolus organizer complex" RELATED [] xref: Wikipedia:Nucleolus_organizer_region is_a: GO:0030874 ! nucleolar chromatin is_a: GO:0043234 ! protein complex [Term] id: GO:0005732 name: small nucleolar ribonucleoprotein complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897] comment: Note that 'nucleolar' in the term name is part of the RNA family designation 'small nucleolar', and does not necessarily reflect the location of the complex. subset: goslim_pir synonym: "small nucleolar ribonucleoprotein" EXACT [] synonym: "snoRNP" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0005733 name: small nucleolar RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "snoRNA" EXACT [] is_obsolete: true [Term] id: GO:0005734 name: box C + D snoRNP protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0005735 name: box H + ACA snoRNP protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0005736 name: DNA-directed RNA polymerase I complex namespace: cellular_component def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase I activity" RELATED [] is_a: GO:0044452 ! nucleolar part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cytoplasm is_a: GO:0044424 ! intracellular part [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005740 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast is_a: GO:0031967 ! organelle envelope is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0005741 name: mitochondrial outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] synonym: "outer mitochondrial membrane" EXACT [] xref: NIF_Subcellular:sao1289741256 xref: Wikipedia:Outer_mitochondrial_membrane is_a: GO:0031966 ! mitochondrial membrane is_a: GO:0031968 ! organelle outer membrane [Term] id: GO:0005742 name: mitochondrial outer membrane translocase complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629] synonym: "GIP complex" NARROW [] synonym: "TOM complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0005743 name: mitochondrial inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] synonym: "inner mitochondrial membrane" EXACT [] xref: NIF_Subcellular:sao1371347282 xref: Wikipedia:Inner_mitochondrial_membrane is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031966 ! mitochondrial membrane [Term] id: GO:0005744 name: mitochondrial inner membrane presequence translocase complex namespace: cellular_component def: "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. subset: goslim_pir synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT [] synonym: "mitochondrial inner membrane translocase complex" EXACT [] synonym: "Tim23 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0005745 name: m-AAA complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [GOC:mcc, PMID:12417197, PMID:21147776] is_a: GO:0031305 ! integral to mitochondrial inner membrane is_a: GO:0043234 ! protein complex [Term] id: GO:0005746 name: mitochondrial respiratory chain namespace: cellular_component def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684] synonym: "mitochondrial electron transport chain" EXACT [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0070469 ! respiratory chain relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0005747 name: mitochondrial respiratory chain complex I namespace: cellular_component alt_id: GO:0005748 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045271 ! respiratory chain complex I relationship: part_of GO:0005746 ! mitochondrial respiratory chain [Term] id: GO:0005749 name: mitochondrial respiratory chain complex II namespace: cellular_component alt_id: GO:0008136 alt_id: GO:0009362 alt_id: GO:0019738 alt_id: GO:0030390 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, ISBN:0198547684] synonym: "mitochondrial fumarate reductase complex" EXACT [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) is_a: GO:0045283 ! fumarate reductase complex relationship: part_of GO:0005746 ! mitochondrial respiratory chain [Term] id: GO:0005750 name: mitochondrial respiratory chain complex III namespace: cellular_component alt_id: GO:0015008 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] synonym: "mitochondrial complex III" EXACT [GOC:mcc] synonym: "mitochondrial cytochrome bc(1) complex" EXACT [GOC:mcc] synonym: "mitochondrial cytochrome bc1 complex" EXACT [GOC:mcc] synonym: "mitochondrial electron transport complex III" RELATED [GOC:mcc] synonym: "mitochondrial ubiquinol-cytochrome c oxidoreductase complex" EXACT [GOC:mcc] synonym: "mitochondrial ubiquinol-cytochrome-c reductase complex" EXACT [GOC:mcc] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045275 ! respiratory chain complex III relationship: part_of GO:0005746 ! mitochondrial respiratory chain [Term] id: GO:0005751 name: mitochondrial respiratory chain complex IV namespace: cellular_component alt_id: GO:0005752 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045277 ! respiratory chain complex IV relationship: part_of GO:0005746 ! mitochondrial respiratory chain [Term] id: GO:0005753 name: mitochondrial proton-transporting ATP synthase complex namespace: cellular_component alt_id: GO:0016470 def: "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu] synonym: "mitochondrial respiratory chain complex V" EXACT [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045259 ! proton-transporting ATP synthase complex relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0005754 name: mitochondrial proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0005755 name: hydrogen-transporting ATP synthase, coupling factor CF(0) namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. is_obsolete: true consider: GO:0045263 [Term] id: GO:0005756 name: mitochondrial proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0005757 name: mitochondrial permeability transition pore complex namespace: cellular_component def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol." [PMID:10393078] synonym: "mitochondrial PT pore complex" EXACT [] is_a: GO:0044429 ! mitochondrial part is_a: GO:0046930 ! pore complex relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0005758 name: mitochondrial intermembrane space namespace: cellular_component alt_id: GO:0031971 def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] synonym: "mitochondrial envelope lumen" EXACT [] synonym: "mitochondrial membrane lumen" RELATED [] xref: NIF_Subcellular:sao118944228 is_a: GO:0031970 ! organelle envelope lumen is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0005759 name: mitochondrial matrix namespace: cellular_component alt_id: GO:0031980 def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "mitochondrial lumen" EXACT [] synonym: "mitochondrial stroma" NARROW [] xref: NIF_Subcellular:sao-1899375636 xref: NIF_Subcellular:sao1804523077 xref: Wikipedia:Mitochondrial_matrix is_a: GO:0044429 ! mitochondrial part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005760 name: gamma DNA polymerase complex namespace: cellular_component def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005761 name: mitochondrial ribosome namespace: cellular_component def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "55S ribosome, mitochondrial" NARROW [] is_a: GO:0000313 ! organellar ribosome is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005762 name: mitochondrial large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] synonym: "39S ribosomal subunit, mitochondrial" NARROW [] is_a: GO:0000315 ! organellar large ribosomal subunit is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005761 ! mitochondrial ribosome [Term] id: GO:0005763 name: mitochondrial small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] synonym: "28S ribosomal subunit, mitochondrial" NARROW [] synonym: "mitochondrial ribosomal small subunit complex" EXACT [] synonym: "mitochondrial ribosomal SSU complex" EXACT [] is_a: GO:0000314 ! organellar small ribosomal subunit is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005761 ! mitochondrial ribosome [Term] id: GO:0005764 name: lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao585356902 xref: Wikipedia:Lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005765 name: lysosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0005766 name: primary lysosome namespace: cellular_component def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] xref: NIF_Subcellular:sao1140587416 is_a: GO:0005764 ! lysosome [Term] id: GO:0005767 name: secondary lysosome namespace: cellular_component def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194] xref: NIF_Subcellular:sao1549842807 is_a: GO:0005764 ! lysosome [Term] id: GO:0005768 name: endosome namespace: cellular_component def: "A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:19696797] subset: goslim_generic subset: goslim_pir subset: goslim_plant xref: NIF_Subcellular:sao1720343330 xref: Wikipedia:Endosome is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005769 name: early endosome namespace: cellular_component def: "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, PMID:19696797] is_a: GO:0005768 ! endosome [Term] id: GO:0005770 name: late endosome namespace: cellular_component def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [PMID:11964142, PMID:2557062] synonym: "prevacuolar compartment" EXACT [] synonym: "PVC" BROAD [] is_a: GO:0005768 ! endosome [Term] id: GO:0005771 name: multivesicular body namespace: cellular_component def: "A type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881] synonym: "multivesicular endosome" EXACT [PMID:12122203] synonym: "MVB" EXACT [] synonym: "MVE" EXACT [PMID:12122203] xref: NIF_Subcellular:sao2045955158 is_a: GO:0005770 ! late endosome [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005774 name: vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] subset: gosubset_prok is_a: GO:0031090 ! organelle membrane is_a: GO:0044437 ! vacuolar part [Term] id: GO:0005775 name: vacuolar lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0044437 ! vacuolar part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005776 name: autophagic vacuole namespace: cellular_component def: "A double-membrane-bounded compartment in which endogenous cellular material is sequestered; known as autophagosome in yeast." [ISBN:0198547684, PMID:11099404] synonym: "autophagosome" EXACT [] is_a: GO:0005773 ! vacuole [Term] id: GO:0005777 name: peroxisome namespace: cellular_component alt_id: GO:0019818 def: "A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [ISBN:0815316194] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "peroxisome vesicle" BROAD [] xref: NIF_Subcellular:sao499555322 xref: Wikipedia:Peroxisome is_a: GO:0042579 ! microbody [Term] id: GO:0005778 name: peroxisomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a peroxisome." [GOC:mah] synonym: "peroxisome membrane" EXACT [] is_a: GO:0031903 ! microbody membrane is_a: GO:0044439 ! peroxisomal part [Term] id: GO:0005779 name: integral to peroxisomal membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031231 ! intrinsic to peroxisomal membrane is_a: GO:0031301 ! integral to organelle membrane [Term] id: GO:0005780 name: extrinsic to intraperoxisomal membrane namespace: cellular_component def: "Loosely bound to the intraperoxisomal surface of the peroxisomal membrane, but not integrated into the hydrophobic region." [GOC:mah] synonym: "intra-peroxisomal peripheral membrane" RELATED [] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044439 ! peroxisomal part relationship: part_of GO:0005778 ! peroxisomal membrane [Term] id: GO:0005781 name: peroxisome targeting signal receptor complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric. is_obsolete: true consider: GO:0000268 consider: GO:0006625 consider: GO:0044439 [Term] id: GO:0005782 name: peroxisomal matrix namespace: cellular_component alt_id: GO:0031909 def: "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194] synonym: "peroxisomal lumen" EXACT [] is_a: GO:0031907 ! microbody lumen is_a: GO:0044439 ! peroxisomal part [Term] id: GO:0005783 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "ER" EXACT [] xref: NIF_Subcellular:sao1036339110 xref: Wikipedia:Endoplasmic_reticulum is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005784 name: Sec61 translocon complex namespace: cellular_component def: "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647] subset: goslim_pir synonym: "Sec61p-Sbh1p-Sss1p complex" NARROW [GOC:mah] is_a: GO:0071256 ! translocon complex [Term] id: GO:0005785 name: signal recognition particle receptor complex namespace: cellular_component def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "docking protein complex" RELATED [] synonym: "SR complex" EXACT [] is_a: GO:0043235 ! receptor complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane [Term] id: GO:0005786 name: signal recognition particle, endoplasmic reticulum targeting namespace: cellular_component alt_id: GO:0005855 def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "signal sequence receptor complex" EXACT [] synonym: "SRP" EXACT [] xref: Wikipedia:Signal_recognition_particle is_a: GO:0048500 ! signal recognition particle [Term] id: GO:0005787 name: signal peptidase complex namespace: cellular_component def: "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0005788 name: endoplasmic reticulum lumen namespace: cellular_component alt_id: GO:0016022 def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] synonym: "cisternal lumen" EXACT [] synonym: "endoplasmic reticulum cisterna" EXACT [] synonym: "ER cisterna" EXACT [] synonym: "ER lumen" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005789 name: endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] synonym: "ER membrane" EXACT [] is_a: GO:0031090 ! organelle membrane is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005790 name: smooth endoplasmic reticulum namespace: cellular_component def: "The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "SER" EXACT [] synonym: "smooth ER" EXACT [] xref: NIF_Subcellular:sao710427438 xref: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005791 name: rough endoplasmic reticulum namespace: cellular_component def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "RER" EXACT [] synonym: "rough ER" EXACT [] xref: NIF_Subcellular:sao1881364067 xref: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005792 name: microsome namespace: cellular_component def: "Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. synonym: "microsomal membrane" RELATED [] xref: Wikipedia:Microsome is_a: GO:0042598 ! vesicular fraction [Term] id: GO:0005793 name: ER-Golgi intermediate compartment namespace: cellular_component def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [PMID:16723730] synonym: "endoplasmic reticulum-Golgi intermediate compartment" EXACT [] synonym: "ERGIC" EXACT [] synonym: "pre-Golgi intermediate compartment" EXACT [] synonym: "vesicular-tubular cluster" EXACT [Wikipedia:Vesicular-tubular_cluster] xref: Wikipedia:Vesicular-tubular_cluster is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005795 name: Golgi stack namespace: cellular_component alt_id: GO:0016940 def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] synonym: "dictyosome" NARROW [] synonym: "Golgi cisternae" EXACT [] is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0005796 name: Golgi lumen namespace: cellular_component def: "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah] is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005797 name: Golgi medial cisterna namespace: cellular_component def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0005798 name: Golgi-associated vesicle namespace: cellular_component def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] comment: Note that this definition includes vesicles that are transiently associated with the Golgi. synonym: "Golgi vesicle" RELATED [] xref: NIF_Subcellular:sao819927218 is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0005799 name: coatomer namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself. synonym: "COPI vesicle" RELATED [] is_obsolete: true consider: GO:0030126 consider: GO:0030137 [Term] id: GO:0005800 name: COPII vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true consider: GO:0030134 [Term] id: GO:0005801 name: cis-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815316194] synonym: "cis Golgi network" EXACT [] synonym: "forming face" RELATED [] synonym: "Golgi cis face" RELATED [] synonym: "Golgi cis-face" RELATED [] is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0005802 name: trans-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located at the side of the Golgi apparatus distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] synonym: "Golgi trans face" RELATED [] synonym: "Golgi trans-face" RELATED [] synonym: "late Golgi" RELATED [GOC:mah] synonym: "maturing face" RELATED [] synonym: "TGN" EXACT [] synonym: "trans Golgi network" EXACT [] xref: NIF_Subcellular:sao9456487 is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0005803 name: secretory vesicle namespace: cellular_component def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684] comment: This term was made obsolete because it was being used to describe two different components. synonym: "transition vesicle" NARROW [] is_obsolete: true consider: GO:0030133 consider: GO:0030141 [Term] id: GO:0005804 name: secretory vesicle membrane namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its parent was made obsolete. is_obsolete: true consider: GO:0030658 consider: GO:0030667 [Term] id: GO:0005805 name: ER-Golgi transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true consider: GO:0030134 [Term] id: GO:0005806 name: Golgi-ER transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true consider: GO:0030142 [Term] id: GO:0005808 name: Golgi-plasma membrane transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles. is_obsolete: true consider: GO:0030133 [Term] id: GO:0005809 name: Golgi-vacuole transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true consider: GO:0030133 [Term] id: GO:0005810 name: endocytotic transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true replaced_by: GO:0030139 [Term] id: GO:0005811 name: lipid particle namespace: cellular_component def: "Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins." [GOC:mah] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid droplet" EXACT [] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005813 name: centrosome namespace: cellular_component def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] subset: goslim_pir xref: Wikipedia:Centrosome is_a: GO:0005815 ! microtubule organizing center is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005814 name: centriole namespace: cellular_component def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] xref: NIF_Subcellular:sao95019936 xref: Wikipedia:Centriole is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0005815 name: microtubule organizing center namespace: cellular_component def: "A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416] subset: goslim_candida subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: Wikipedia:Microtubule_organizing_center is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005816 name: spindle pole body namespace: cellular_component def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568] synonym: "SPB" EXACT [GOC:mah] xref: Wikipedia:Spindle_pole_body is_a: GO:0005815 ! microtubule organizing center relationship: part_of GO:0000922 ! spindle pole [Term] id: GO:0005817 name: centrosomal mitotic factor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:clt] comment: This term was made obsolete because it was not defined. is_obsolete: true [Term] id: GO:0005818 name: aster namespace: cellular_component def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle [Term] id: GO:0005819 name: spindle namespace: cellular_component def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] xref: Wikipedia:Spindle_apparatus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005821 name: intermediate layer of spindle pole body namespace: cellular_component def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005822 name: inner plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005823 name: central plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005824 name: outer plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005825 name: half bridge of spindle pole body namespace: cellular_component def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005826 name: actomyosin contractile ring namespace: cellular_component alt_id: GO:0030480 def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194] synonym: "actomyosin ring" RELATED [] synonym: "CAR" EXACT [] synonym: "constriction ring" RELATED [] synonym: "contractile actomyosin ring" EXACT [] synonym: "cytokinetic ring" NARROW [] is_a: GO:0032155 ! cell division site part is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part is_a: GO:0070938 ! contractile ring relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005827 name: polar microtubule namespace: cellular_component def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194] synonym: "pole-to-pole microtubule" EXACT [] is_a: GO:0005876 ! spindle microtubule relationship: part_of GO:0000922 ! spindle pole [Term] id: GO:0005828 name: kinetochore microtubule namespace: cellular_component def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] synonym: "pole-to-kinetochore microtubule" EXACT [] is_a: GO:0005876 ! spindle microtubule [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hgd, GOC:jl] subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005831 name: steroid hormone aporeceptor complex namespace: cellular_component def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005832 name: chaperonin-containing T-complex namespace: cellular_component def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] synonym: "CCT particle" EXACT [] synonym: "TriC" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005833 name: hemoglobin complex namespace: cellular_component def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "haemoglobin complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005834 name: heterotrimeric G-protein complex namespace: cellular_component def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] comment: See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'. subset: gosubset_prok synonym: "heterotrimeric G-protein GTPase activity" RELATED [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW [] is_a: GO:0031234 ! extrinsic to internal side of plasma membrane is_a: GO:0043234 ! protein complex [Term] id: GO:0005835 name: fatty acid synthase complex namespace: cellular_component alt_id: GO:0031373 alt_id: GO:0031374 def: "A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA." [GOC:pde, GOC:sgd_curators, ISBN:0716746840] subset: goslim_pir subset: gosubset_prok synonym: "cytosolic FAS complex" EXACT [] synonym: "cytosolic fatty acid synthase complex" EXACT [] synonym: "cytosolic type I FAS complex" EXACT [] synonym: "cytosolic type I fatty acid synthase complex" EXACT [] synonym: "FAS complex" EXACT [] synonym: "fatty acid synthetase complex" EXACT [] synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED [] xref: Wikipedia:Fatty_acid_synthetase_complex is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005836 name: fatty-acyl-CoA synthase complex namespace: cellular_component def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [BRENDA:2.3.1.86, GOC:mah] comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes. synonym: "fatty acyl CoA synthase complex" EXACT [GOC:curators] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005837 name: 26S proteasome namespace: cellular_component def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin group. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0000502 [Term] id: GO:0005838 name: proteasome regulatory particle namespace: cellular_component def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] synonym: "19S regulatory particle" NARROW [] synonym: "modulator complex" RELATED [CORUM:28] synonym: "PA700 proteasome activator" NARROW [] synonym: "PA700-dependent proteasome activator" EXACT [CORUM:28] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0005839 name: proteasome core complex namespace: cellular_component alt_id: GO:0000503 def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] synonym: "20S core complex" NARROW [] synonym: "20S proteasome" NARROW [GOC:cjk] synonym: "macropain" EXACT [] synonym: "PA28gamma-20S proteasome" NARROW [CORUM:194] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0000502 ! proteasome complex [Term] id: GO:0005840 name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "ribosomal RNA" RELATED [] synonym: "ribosomal subunit" RELATED [GOC:mah, GOC:vw] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005844 name: polysome namespace: cellular_component def: "Several ribosomes bound to one mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir synonym: "polyribosome" EXACT [] xref: Wikipedia:Polysome is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0005845 name: mRNA cap binding complex namespace: cellular_component def: "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jid] synonym: "mRNA cap complex" RELATED [] is_a: GO:0034518 ! RNA cap binding complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005846 name: nuclear cap binding complex namespace: cellular_component def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498] comment: Note that this complex can be found in the cytoplasm as well as the nucleus. synonym: "CBC" RELATED [] synonym: "mRNA cap binding complex" NARROW [] synonym: "NCBP-NIP1 complex" NARROW [] synonym: "snRNA cap binding complex" NARROW [] is_a: GO:0034518 ! RNA cap binding complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005847 name: mRNA cleavage and polyadenylation specificity factor complex namespace: cellular_component def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727] synonym: "CFII complex" RELATED [] synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] synonym: "CPF complex" NARROW [] synonym: "CPSF complex" NARROW [] is_a: GO:0005849 ! mRNA cleavage factor complex [Term] id: GO:0005848 name: mRNA cleavage stimulating factor complex namespace: cellular_component def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856] synonym: "cleavage stimulation factor activity" RELATED [] synonym: "CstF complex" NARROW [] is_a: GO:0005849 ! mRNA cleavage factor complex [Term] id: GO:0005849 name: mRNA cleavage factor complex namespace: cellular_component def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0005850 name: eukaryotic translation initiation factor 2 complex namespace: cellular_component def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940] synonym: "eIF-2" EXACT [] synonym: "eIF2" EXACT [GOC:mah] xref: Wikipedia:EIF-2 is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005851 name: eukaryotic translation initiation factor 2B complex namespace: cellular_component def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] synonym: "eIF-2B" EXACT [] synonym: "eif2B" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005852 name: eukaryotic translation initiation factor 3 complex namespace: cellular_component def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] synonym: "eIF-3" EXACT [] synonym: "eIF3" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005853 name: eukaryotic translation elongation factor 1 complex namespace: cellular_component def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005854 name: nascent polypeptide-associated complex namespace: cellular_component def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] synonym: "NAC" EXACT [] synonym: "NACA" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005858 name: axonemal dynein complex namespace: cellular_component def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains." [ISBN:0815316194] synonym: "axonemal dynein heavy chain" NARROW [] synonym: "axonemal dynein intermediate chain" NARROW [] synonym: "axonemal dynein intermediate light chain" NARROW [] synonym: "axonemal dynein light chain" NARROW [] is_a: GO:0030286 ! dynein complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0005859 name: muscle myosin complex namespace: cellular_component def: "A filament of myosin found in a muscle cell of any type." [GOC:mah] is_a: GO:0016460 ! myosin II complex is_a: GO:0044449 ! contractile fiber part [Term] id: GO:0005861 name: troponin complex namespace: cellular_component def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0005865 ! striated muscle thin filament [Term] id: GO:0005862 name: muscle thin filament tropomyosin namespace: cellular_component def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0005865 ! striated muscle thin filament [Term] id: GO:0005863 name: striated muscle myosin thick filament namespace: cellular_component def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194] is_a: GO:0005859 ! muscle myosin complex is_a: GO:0032982 ! myosin filament relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0005865 name: striated muscle thin filament namespace: cellular_component def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0015629 ! actin cytoskeleton relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0005868 name: cytoplasmic dynein complex namespace: cellular_component def: "Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311] synonym: "cytoplasmic dynein heavy chain" NARROW [] synonym: "cytoplasmic dynein intermediate chain" NARROW [] synonym: "cytoplasmic dynein intermediate light chain" NARROW [] synonym: "cytoplasmic dynein light chain" NARROW [] is_a: GO:0030286 ! dynein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005869 name: dynactin complex namespace: cellular_component def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005875 ! microtubule associated complex relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005870 name: actin capping protein of dynactin complex namespace: cellular_component def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, PMID:18221362, PMID:18544499] is_a: GO:0008290 ! F-actin capping protein complex relationship: part_of GO:0005869 ! dynactin complex [Term] id: GO:0005871 name: kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] is_a: GO:0005875 ! microtubule associated complex [Term] id: GO:0005872 name: minus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0005873 name: plus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0005874 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] synonym: "microtubuli" EXACT [] synonym: "microtubulus" EXACT [] xref: NIF_Subcellular:sao1846835077 xref: Wikipedia:Microtubule is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005875 name: microtubule associated complex namespace: cellular_component def: "Any multimeric complex connected to a microtubule." [GOC:jl] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005876 name: spindle microtubule namespace: cellular_component def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] is_a: GO:0005874 ! microtubule relationship: part_of GO:0005819 ! spindle [Term] id: GO:0005879 name: axonemal microtubule namespace: cellular_component def: "A microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [ISBN:0815316194] is_a: GO:0005874 ! microtubule is_a: GO:0044447 ! axoneme part [Term] id: GO:0005880 name: nuclear microtubule namespace: cellular_component def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule is_a: GO:0044428 ! nuclear part [Term] id: GO:0005881 name: cytoplasmic microtubule namespace: cellular_component def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] synonym: "non-spindle-associated astral microtubule" NARROW [] is_a: GO:0005874 ! microtubule is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005882 name: intermediate filament namespace: cellular_component def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "intermediate filament associated protein" RELATED [] synonym: "type I intermediate filament associated protein" RELATED [] synonym: "type II intermediate filament associated protein" RELATED [] xref: NIF_Subcellular:sao952483289 xref: Wikipedia:Intermediate_filament is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0045111 ! intermediate filament cytoskeleton [Term] id: GO:0005883 name: neurofilament namespace: cellular_component def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363, ISBN:0815316194] synonym: "type IV intermediate filament" EXACT [] xref: NIF_Subcellular:sao1316272517 xref: Wikipedia:Neurofilament is_a: GO:0005882 ! intermediate filament is_a: GO:0033267 ! axon part relationship: part_of GO:0060053 ! neurofilament cytoskeleton [Term] id: GO:0005884 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10666339] synonym: "microfilament" EXACT [] xref: NIF_Subcellular:sao1588493326 xref: Wikipedia:Actin is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005885 name: Arp2/3 protein complex namespace: cellular_component def: "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005887 name: integral to plasma membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] subset: gosubset_prok is_a: GO:0016021 ! integral to membrane is_a: GO:0031226 ! intrinsic to plasma membrane [Term] id: GO:0005888 name: proteoglycan integral to plasma membrane namespace: cellular_component def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product. is_obsolete: true replaced_by: GO:0005887 [Term] id: GO:0005889 name: hydrogen:potassium-exchanging ATPase complex namespace: cellular_component def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of Na+ and K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431] synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT [] synonym: "proton pump" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005890 name: sodium:potassium-exchanging ATPase complex namespace: cellular_component def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "sodium pump" BROAD [] synonym: "sodium/potassium-exchanging ATPase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005891 name: voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah] subset: goslim_pir synonym: "voltage gated calcium channel complex" EXACT [] synonym: "voltage-dependent calcium channel complex" EXACT [] synonym: "voltage-sensitive calcium channel complex" EXACT [] is_a: GO:0034704 ! calcium channel complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0005892 name: nicotinic acetylcholine-gated receptor-channel complex namespace: cellular_component def: "A protein complex that acts as an acetylcholine receptor, and forms a transmembrane channel through which ions may pass in response to ligand binding. The complex is a homo- or heteropentamer of subunits that are members of a neurotransmitter receptor superfamily." [GOC:mah, PMID:12381728, PMID:15579462] synonym: "nicotinic acetylcholine receptor" BROAD [] is_a: GO:0034702 ! ion channel complex is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005893 name: interleukin-2 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078] synonym: "IL-2 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005894 name: interleukin-3 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579] synonym: "IL-3 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005895 name: interleukin-5 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579] synonym: "IL-5 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005896 name: interleukin-6 receptor complex namespace: cellular_component def: "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235] synonym: "IL-6 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005897 name: interleukin-9 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536] synonym: "IL-9 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005898 name: interleukin-13 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain." [PMID:8552669, PMID:9013879] synonym: "IL-13 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005899 name: insulin receptor complex namespace: cellular_component def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005900 name: oncostatin-M receptor complex namespace: cellular_component def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005901 name: caveola namespace: cellular_component alt_id: GO:0016599 def: "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include any of the minute pits or incuppings of the cell membrane formed during pinocytosis. Such caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:16645198] synonym: "caveolae" EXACT [] synonym: "caveolar membrane" RELATED [] xref: Wikipedia:Caveolae is_a: GO:0044459 ! plasma membrane part is_a: GO:0045121 ! membrane raft [Term] id: GO:0005902 name: microvillus namespace: cellular_component def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194] comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. subset: goslim_pir xref: Wikipedia:Microvillus is_a: GO:0042995 ! cell projection [Term] id: GO:0005903 name: brush border namespace: cellular_component def: "Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] subset: goslim_pir xref: Wikipedia:Brush_border is_a: GO:0042995 ! cell projection [Term] id: GO:0005905 name: coated pit namespace: cellular_component def: "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10559856, PMID:17284835] is_a: GO:0044425 ! membrane part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005906 name: clathrin adaptor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean. synonym: "adaptin" RELATED [] is_obsolete: true replaced_by: GO:0030119 [Term] id: GO:0005907 name: HA1 clathrin adaptor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. synonym: "AP1" RELATED [] is_obsolete: true consider: GO:0030121 [Term] id: GO:0005908 name: HA2 clathrin adaptor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. synonym: "AP2" RELATED [] is_obsolete: true consider: GO:0030122 [Term] id: GO:0005911 name: cell-cell junction namespace: cellular_component def: "A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah] synonym: "intercellular junction" EXACT [] xref: NIF_Subcellular:sao1922892319 is_a: GO:0030054 ! cell junction [Term] id: GO:0005912 name: adherens junction namespace: cellular_component def: "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0070161 ! anchoring junction [Term] id: GO:0005913 name: cell-cell adherens junction namespace: cellular_component def: "An adherens junction which connects two cells to each other." [GOC:hb] is_a: GO:0005911 ! cell-cell junction is_a: GO:0005912 ! adherens junction [Term] id: GO:0005914 name: spot adherens junction namespace: cellular_component def: "A small junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298] synonym: "dense plaque" BROAD [] synonym: "punctum adherens" EXACT [] is_a: GO:0005913 ! cell-cell adherens junction [Term] id: GO:0005915 name: zonula adherens namespace: cellular_component def: "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] synonym: "adhesion belt" EXACT [] synonym: "belt desmosome" EXACT [] synonym: "fascia adhaerens" EXACT [] synonym: "intermediate junction" EXACT [] synonym: "zonula adhaerens" EXACT [] xref: NIF_Subcellular:sao1400623473 is_a: GO:0005913 ! cell-cell adherens junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005916 name: fascia adherens namespace: cellular_component def: "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:mtg_muscle, PMID:11732910] xref: Wikipedia:Fascia_adherens is_a: GO:0005913 ! cell-cell adherens junction relationship: part_of GO:0014704 ! intercalated disc [Term] id: GO:0005917 name: nephrocyte junction namespace: cellular_component def: "A tissue-specific adherens junction found between nephrocyte cells. A nephrocyte is an insect excretory cell that regulates hemolymph composition by filtration and filtrate endocytosis." [CL:0002520, http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm] is_a: GO:0005913 ! cell-cell adherens junction [Term] id: GO:0005918 name: septate junction namespace: cellular_component def: "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] synonym: "septate desmosome" RELATED [] xref: NIF_Subcellular:sao427941916 is_a: GO:0070160 ! occluding junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005919 name: pleated septate junction namespace: cellular_component def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] synonym: "pleated desmosome" RELATED [] is_a: GO:0005918 ! septate junction [Term] id: GO:0005920 name: smooth septate junction namespace: cellular_component def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] synonym: "zonula continua" EXACT [] is_a: GO:0005918 ! septate junction [Term] id: GO:0005921 name: gap junction namespace: cellular_component def: "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181] synonym: "communicating junction" EXACT [] synonym: "macula communicans" EXACT [] synonym: "zonula communicans" EXACT [] xref: NIF_Subcellular:sao118541872 xref: Wikipedia:Gap_junction is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0005922 name: connexon complex namespace: cellular_component def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276] xref: NIF_Subcellular:sao445019788 is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005921 ! gap junction [Term] id: GO:0005923 name: tight junction namespace: cellular_component def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] synonym: "zonula occludens" EXACT [] xref: NIF_Subcellular:sao1939999134 xref: Wikipedia:Tight_junction is_a: GO:0070160 ! occluding junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005924 name: cell-substrate adherens junction namespace: cellular_component def: "An adherens junction which connects a cell to the extracellular matrix." [GOC:hb] synonym: "hemi-adherens junction" RELATED [] is_a: GO:0005912 ! adherens junction is_a: GO:0030055 ! cell-substrate junction [Term] id: GO:0005925 name: focal adhesion namespace: cellular_component alt_id: GO:0008357 def: "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] synonym: "focal contact" EXACT [] synonym: "hemi-adherens junction" RELATED [] xref: Wikipedia:Focal_adhesion is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005926 name: connecting hemi-adherens junction namespace: cellular_component def: "A cell-substrate adherens junction, also known as a hemiadherens junction (HAJ) that forms one of a pair of junctions in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects)." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm] is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005927 name: muscle tendon junction namespace: cellular_component def: "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007] synonym: "myotendinous junction" EXACT [] is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005928 name: apical hemi-adherens junction namespace: cellular_component def: "A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298] synonym: "apical cell-substrate adherens junction" EXACT [GOC:mah] synonym: "apical dense plaque" EXACT [] is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005929 name: cilium namespace: cellular_component def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, ISBN:0198547684] subset: goslim_generic subset: goslim_pir xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0042995 ! cell projection [Term] id: GO:0005930 name: axoneme namespace: cellular_component def: "The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [ISBN:0198547684] xref: Wikipedia:Axoneme is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0005931 name: nexin complex namespace: cellular_component def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0005932 name: microtubule basal body namespace: cellular_component def: "A short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum that is similar in structure to a centriole. The basal body serves as a nucleation site for axoneme growth." [GOC:clt] xref: NIF_Subcellular:sao11978067 is_a: GO:0005815 ! microtubule organizing center is_a: GO:0044463 ! cell projection part [Term] id: GO:0005933 name: cellular bud namespace: cellular_component def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators] subset: goslim_candida subset: goslim_pir subset: goslim_yeast is_a: GO:0044464 ! cell part [Term] id: GO:0005934 name: cellular bud tip namespace: cellular_component def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah] is_a: GO:0030427 ! site of polarized growth relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0005935 name: cellular bud neck namespace: cellular_component def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah] is_a: GO:0030427 ! site of polarized growth relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0005936 name: shmoo namespace: cellular_component def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc] comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'. is_obsolete: true consider: GO:0001400 consider: GO:0005937 [Term] id: GO:0005937 name: mating projection namespace: cellular_component def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc] subset: goslim_pir synonym: "conjugation tube" NARROW [] synonym: "shmoo" NARROW [] is_a: GO:0042995 ! cell projection [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005940 name: septin ring namespace: cellular_component alt_id: GO:0030481 def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244] xref: Wikipedia:Septin_ring is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part [Term] id: GO:0005941 name: unlocalized protein complex namespace: cellular_component def: "OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma] comment: This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed. is_obsolete: true [Term] id: GO:0005942 name: phosphatidylinositol 3-kinase complex namespace: cellular_component def: "A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K)." [GOC:bf] subset: goslim_pir synonym: "1-phosphatidylinositol 3-kinase complex" EXACT [] synonym: "phosphoinositide 3-kinase complex" EXACT [GOC:curators] synonym: "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex" NARROW [CORUM:2575] synonym: "PI3K complex" EXACT [] synonym: "PIK3C3-PIK3R4 complex" NARROW [CORUM:429] synonym: "PIK3CA-PIK3R1 complex" NARROW [CORUM:439] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005943 name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex namespace: cellular_component alt_id: GO:0035030 def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT [] synonym: "class IA PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IA" EXACT [] is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex [Term] id: GO:0005944 name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex namespace: cellular_component alt_id: GO:0035031 def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED [] synonym: "class IB PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IB" EXACT [] is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex [Term] id: GO:0005945 name: 6-phosphofructokinase complex namespace: cellular_component def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005946 name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) namespace: cellular_component def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904] comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'. synonym: "trehalose-6-phosphate synthase complex" EXACT [] synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005947 name: mitochondrial alpha-ketoglutarate dehydrogenase complex namespace: cellular_component def: "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex [Term] id: GO:0005948 name: acetolactate synthase complex namespace: cellular_component def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, PMID:16458324, PMID:8756689] comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. subset: gosubset_prok synonym: "acetohydroxyacid synthase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005949 name: aminoadipate-semialdehyde dehydrogenase complex namespace: cellular_component def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31] comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products. is_obsolete: true [Term] id: GO:0005950 name: anthranilate synthase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, MetaCyc:ANTHRANSYN-CPLX, PMID:4886290] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005951 name: carbamoyl-phosphate synthase complex namespace: cellular_component def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695] comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. subset: gosubset_prok synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW [] synonym: "carbamoyl phosphate synthase complex" EXACT [] synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005952 name: cAMP-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "3',5' cAMP-dependent protein kinase complex" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT [] synonym: "cyclic AMP-dependent protein kinase complex" EXACT [] synonym: "PKA" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005953 name: CAAX-protein geranylgeranyltransferase complex namespace: cellular_component def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005954 name: calcium- and calmodulin-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17] synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT [] synonym: "CAMK2" EXACT [] synonym: "CaMKII" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005955 name: calcineurin complex namespace: cellular_component def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951] synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW [] synonym: "protein phosphatase type 2B complex" EXACT [] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005956 name: protein kinase CK2 complex namespace: cellular_component def: "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. synonym: "casein kinase II complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005957 name: debranching enzyme namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex. is_obsolete: true consider: GO:0043033 [Term] id: GO:0005958 name: DNA-dependent protein kinase-DNA ligase 4 complex namespace: cellular_component alt_id: GO:0005959 def: "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889] is_a: GO:0044428 ! nuclear part is_a: GO:0070419 ! nonhomologous end joining complex [Term] id: GO:0005960 name: glycine cleavage complex namespace: cellular_component alt_id: GO:0005961 alt_id: GO:0070015 def: "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX] subset: goslim_pir subset: gosubset_prok synonym: "glycine cleavage system" EXACT [] synonym: "glycine decarboxylase complex" EXACT [] synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT [] synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED [] synonym: "glycine synthase complex" EXACT [] xref: Wikipedia:Glycine_decarboxylase_complex is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005962 name: mitochondrial isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'. is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) [Term] id: GO:0005963 name: magnesium-dependent protein serine/threonine phosphatase complex namespace: cellular_component def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [EC:3.1.3.16] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005964 name: phosphorylase kinase complex namespace: cellular_component def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005965 name: protein farnesyltransferase complex namespace: cellular_component def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005966 name: cyclic-nucleotide phosphodiesterase complex namespace: cellular_component def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0005967 name: mitochondrial pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. synonym: "pyruvate dehydrogenase complex (lipoamide)" BROAD [] is_a: GO:0044429 ! mitochondrial part is_a: GO:0045254 ! pyruvate dehydrogenase complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005968 name: Rab-protein geranylgeranyltransferase complex namespace: cellular_component def: "A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein." [GOC:jl, PMID:11886217] synonym: "GGTase-II complex" EXACT [] synonym: "Rab geranylgeranyltransferase complex" EXACT [] synonym: "RAB-protein geranylgeranyltransferase complex" EXACT [] synonym: "RabGGTase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005969 name: serine-pyruvate aminotransferase complex namespace: cellular_component alt_id: GO:0005970 def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005971 name: ribonucleoside-diphosphate reductase complex namespace: cellular_component def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin." [BRENDA:1.17.4.1] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005972 name: fibrinogen alpha chain namespace: cellular_component alt_id: GO:0008005 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0005577 [Term] id: GO:0005973 name: fibrinogen beta chain namespace: cellular_component alt_id: GO:0008006 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0005577 [Term] id: GO:0005974 name: fibrinogen gamma chain namespace: cellular_component alt_id: GO:0008007 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0005577 [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: gosubset_prok synonym: "carbohydrate metabolism" EXACT [] xref: Reactome:1252914 "Metabolism of carbohydrates" xref: Reactome:1279848 "Metabolism of carbohydrates" xref: Reactome:1298763 "Metabolism of carbohydrates" xref: Reactome:1326417 "Metabolism of carbohydrates" xref: Reactome:1352533 "Metabolism of carbohydrates" xref: Reactome:1372761 "Metabolism of carbohydrates" xref: Reactome:1392771 "Metabolism of carbohydrates" xref: Reactome:1417248 "Metabolism of carbohydrates" xref: Reactome:1450336 "Metabolism of carbohydrates" xref: Reactome:1470877 "Metabolism of carbohydrates" xref: Reactome:1482909 "Metabolism of carbohydrates" xref: Reactome:1496705 "Metabolism of carbohydrates" xref: Reactome:1514096 "Metabolism of carbohydrates" xref: Reactome:1520921 "Metabolism of carbohydrates" xref: Reactome:1526667 "Metabolism of carbohydrates" xref: Reactome:1532394 "Metabolism of carbohydrates" xref: Reactome:1535959 "Metabolism of carbohydrates" xref: Reactome:1537969 "Metabolism of carbohydrates" xref: Reactome:1539222 "Metabolism of carbohydrates" xref: Reactome:1540279 "Metabolism of carbohydrates" xref: Reactome:71387 "Metabolism of carbohydrates" xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process [Term] id: GO:0005976 name: polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polysaccharides, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok synonym: "glycan metabolic process" EXACT [] synonym: "glycan metabolism" EXACT [] synonym: "polysaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0005977 name: glycogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycogen metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0006112 ! energy reserve metabolic process [Term] id: GO:0005978 name: glycogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycogen anabolism" EXACT [] synonym: "glycogen biosynthesis" EXACT [] synonym: "glycogen formation" EXACT [] synonym: "glycogen synthesis" EXACT [] xref: MetaCyc:GLYCOGENSYNTH-PWY xref: Reactome:1252915 "Glycogen synthesis" xref: Reactome:1279849 "Glycogen synthesis" xref: Reactome:1298764 "Glycogen synthesis" xref: Reactome:1326418 "Glycogen synthesis" xref: Reactome:1352534 "Glycogen synthesis" xref: Reactome:1372762 "Glycogen synthesis" xref: Reactome:1392772 "Glycogen synthesis" xref: Reactome:1417249 "Glycogen synthesis" xref: Reactome:1450337 "Glycogen synthesis" xref: Reactome:1470878 "Glycogen synthesis" xref: Reactome:1482910 "Glycogen synthesis" xref: Reactome:1496706 "Glycogen synthesis" xref: Reactome:1514097 "Glycogen synthesis" xref: Reactome:1520922 "Glycogen synthesis" xref: Reactome:1526668 "Glycogen synthesis" xref: Reactome:1532395 "Glycogen synthesis" xref: Reactome:1535957 "Glycogen synthesis" xref: Reactome:1537967 "Glycogen synthesis" xref: Reactome:1539223 "Glycogen synthesis" xref: Reactome:1540280 "Glycogen synthesis" xref: Reactome:70302 "Glycogen synthesis" is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009250 ! glucan biosynthetic process [Term] id: GO:0005979 name: regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of glycogen anabolism" EXACT [] synonym: "regulation of glycogen biosynthesis" EXACT [] synonym: "regulation of glycogen formation" EXACT [] synonym: "regulation of glycogen synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0070873 ! regulation of glycogen metabolic process relationship: regulates GO:0005978 ! glycogen biosynthetic process [Term] id: GO:0005980 name: glycogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycogen breakdown" EXACT [] synonym: "glycogen catabolism" EXACT [] synonym: "glycogen degradation" EXACT [] synonym: "glycogenolysis" EXACT [GOC:sl] xref: MetaCyc:GLYCOCAT-PWY xref: Reactome:1252927 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1279861 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1298775 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1326430 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1352546 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1372773 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1392783 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1417260 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1450349 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1470890 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1482922 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1496718 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1514109 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1520929 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1526679 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1532406 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1535965 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1537972 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1539226 "Glycogen breakdown (glycogenolysis)" xref: Reactome:1540283 "Glycogen breakdown (glycogenolysis)" xref: Reactome:70221 "Glycogen breakdown (glycogenolysis)" is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0005981 name: regulation of glycogen catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of glycogen breakdown" EXACT [] synonym: "regulation of glycogen catabolism" EXACT [] synonym: "regulation of glycogen degradation" EXACT [] synonym: "regulation of glycogenolysis" EXACT [GOC:sl] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process relationship: regulates GO:0005980 ! glycogen catabolic process [Term] id: GO:0005982 name: starch metabolic process namespace: biological_process def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "starch metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0005983 name: starch catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai] subset: gosubset_prok synonym: "starch breakdown" EXACT [] synonym: "starch catabolism" EXACT [] synonym: "starch degradation" EXACT [] xref: MetaCyc:PWY-842 is_a: GO:0005982 ! starch metabolic process is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0005984 name: disaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:01928006X] subset: gosubset_prok synonym: "disaccharide metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0005985 name: sucrose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] subset: gosubset_prok synonym: "sucrose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0005986 name: sucrose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] subset: gosubset_prok synonym: "sucrose anabolism" EXACT [] synonym: "sucrose biosynthesis" EXACT [] synonym: "sucrose formation" EXACT [] synonym: "sucrose synthesis" EXACT [] xref: MetaCyc:SUCSYN-PWY is_a: GO:0005985 ! sucrose metabolic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005987 name: sucrose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] subset: gosubset_prok synonym: "sucrose breakdown" EXACT [] synonym: "sucrose catabolism" EXACT [] synonym: "sucrose degradation" EXACT [] is_a: GO:0005985 ! sucrose metabolic process is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005988 name: lactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] subset: gosubset_prok synonym: "lactose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005989 name: lactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] subset: gosubset_prok synonym: "lactose anabolism" EXACT [] synonym: "lactose biosynthesis" EXACT [] synonym: "lactose formation" EXACT [] synonym: "lactose synthesis" EXACT [] is_a: GO:0005988 ! lactose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005990 name: lactose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] subset: gosubset_prok synonym: "lactose breakdown" EXACT [] synonym: "lactose catabolism" EXACT [] synonym: "lactose degradation" EXACT [] is_a: GO:0005988 ! lactose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005991 name: trehalose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] subset: gosubset_prok synonym: "mycose metabolic process" EXACT [] synonym: "mycose metabolism" EXACT [] synonym: "mykose metabolic process" EXACT [] synonym: "mykose metabolism" EXACT [] synonym: "trehalose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0005992 name: trehalose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] subset: gosubset_prok synonym: "mycose biosynthesis" EXACT [] synonym: "mycose biosynthetic process" EXACT [] synonym: "mykose biosynthesis" EXACT [] synonym: "mykose biosynthetic process" EXACT [] synonym: "trehalose anabolism" EXACT [] synonym: "trehalose biosynthesis" EXACT [] synonym: "trehalose formation" EXACT [] synonym: "trehalose synthesis" EXACT [] xref: MetaCyc:PWY-881 xref: MetaCyc:TREHALOSESYN-PWY xref: MetaCyc:TRESYN-PWY xref: Reactome:868688 "Trehalose biosynthesis" is_a: GO:0005991 ! trehalose metabolic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005993 name: trehalose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] subset: gosubset_prok synonym: "mycose catabolic process" EXACT [] synonym: "mycose catabolism" EXACT [] synonym: "mykose catabolic process" EXACT [] synonym: "mykose catabolism" EXACT [] synonym: "trehalose breakdown" EXACT [] synonym: "trehalose catabolism" EXACT [] synonym: "trehalose degradation" EXACT [] xref: MetaCyc:TREDEGLOW-PWY is_a: GO:0005991 ! trehalose metabolic process is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005994 name: melibiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] subset: gosubset_prok synonym: "melibiose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005995 name: melibiose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] subset: gosubset_prok synonym: "melibiose breakdown" EXACT [] synonym: "melibiose catabolism" EXACT [] synonym: "melibiose degradation" EXACT [] is_a: GO:0005994 ! melibiose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005996 name: monosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "monosaccharide metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0005997 name: xylulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] subset: gosubset_prok synonym: "xylulose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0005998 name: xylulose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] subset: gosubset_prok synonym: "xylulose breakdown" EXACT [] synonym: "xylulose catabolism" EXACT [] synonym: "xylulose degradation" EXACT [] xref: MetaCyc:XYLCAT-PWY is_a: GO:0005997 ! xylulose metabolic process is_a: GO:0019323 ! pentose catabolic process [Term] id: GO:0005999 name: xylulose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] subset: gosubset_prok synonym: "xylulose anabolism" EXACT [] synonym: "xylulose biosynthesis" EXACT [] synonym: "xylulose formation" EXACT [] synonym: "xylulose synthesis" EXACT [] xref: Reactome:1253342 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1280280 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1299133 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1326858 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1352949 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1373153 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1393170 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1417657 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1450758 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1471195 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1483192 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1496884 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1514277 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1521143 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1526897 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1532626 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:1538040 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:163754 "Insulin effects increased synthesis of Xylulose-5-Phosphate" is_a: GO:0005997 ! xylulose metabolic process is_a: GO:0019322 ! pentose biosynthetic process [Term] id: GO:0006000 name: fructose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fructose metabolism" EXACT [] xref: Wikipedia:Fructose is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006001 name: fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] subset: gosubset_prok synonym: "fructose breakdown" EXACT [] synonym: "fructose catabolism" EXACT [] synonym: "fructose degradation" EXACT [] xref: Reactome:1252920 "Fructose catabolism" xref: Reactome:1279854 "Fructose catabolism" xref: Reactome:1298769 "Fructose catabolism" xref: Reactome:1326423 "Fructose catabolism" xref: Reactome:1352539 "Fructose catabolism" xref: Reactome:1372767 "Fructose catabolism" xref: Reactome:1392777 "Fructose catabolism" xref: Reactome:1417254 "Fructose catabolism" xref: Reactome:1450342 "Fructose catabolism" xref: Reactome:1470883 "Fructose catabolism" xref: Reactome:1482915 "Fructose catabolism" xref: Reactome:1496711 "Fructose catabolism" xref: Reactome:1514102 "Fructose catabolism" xref: Reactome:1520927 "Fructose catabolism" xref: Reactome:1535960 "Fructose catabolism" xref: Reactome:70350 "Fructose catabolism" is_a: GO:0006000 ! fructose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0006002 name: fructose 6-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fructose 6-phosphate metabolism" EXACT [] is_a: GO:0006000 ! fructose metabolic process [Term] id: GO:0006003 name: fructose 2,6-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fructose 2,6-bisphosphate metabolism" EXACT [] is_a: GO:0006000 ! fructose metabolic process [Term] id: GO:0006004 name: fucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fucose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006005 name: L-fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose)." [GOC:jl] subset: gosubset_prok synonym: "L-fucose anabolism" EXACT [] synonym: "L-fucose biosynthesis" EXACT [] synonym: "L-fucose formation" EXACT [] synonym: "L-fucose synthesis" EXACT [] is_a: GO:0042353 ! fucose biosynthetic process is_a: GO:0042354 ! L-fucose metabolic process [Term] id: GO:0006006 name: glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cellular glucose metabolic process" EXACT [GOC:vw] synonym: "glucose metabolism" EXACT [] xref: Reactome:1252913 "Glucose metabolism" xref: Reactome:1279847 "Glucose metabolism" xref: Reactome:1298762 "Glucose metabolism" xref: Reactome:1326416 "Glucose metabolism" xref: Reactome:1352532 "Glucose metabolism" xref: Reactome:1372760 "Glucose metabolism" xref: Reactome:1392770 "Glucose metabolism" xref: Reactome:1417247 "Glucose metabolism" xref: Reactome:1450335 "Glucose metabolism" xref: Reactome:1470876 "Glucose metabolism" xref: Reactome:1482908 "Glucose metabolism" xref: Reactome:1496704 "Glucose metabolism" xref: Reactome:1514095 "Glucose metabolism" xref: Reactome:1520920 "Glucose metabolism" xref: Reactome:1526666 "Glucose metabolism" xref: Reactome:1532393 "Glucose metabolism" xref: Reactome:1535958 "Glucose metabolism" xref: Reactome:1537968 "Glucose metabolism" xref: Reactome:1539221 "Glucose metabolism" xref: Reactome:1540278 "Glucose metabolism" xref: Reactome:70326 "Glucose metabolism" is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006007 name: glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] subset: gosubset_prok synonym: "glucose breakdown" EXACT [] synonym: "glucose catabolism" EXACT [] synonym: "glucose degradation" EXACT [] is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0006009 name: glucose 1-phosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." [GOC:ai] subset: gosubset_prok is_a: GO:0019255 ! glucose 1-phosphate metabolic process is_a: GO:0046835 ! carbohydrate phosphorylation [Term] id: GO:0006011 name: UDP-glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-glucose metabolism" EXACT [] is_a: GO:0006006 ! glucose metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0006012 name: galactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactose metabolism" EXACT [] xref: Wikipedia:Galactose is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006013 name: mannose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006014 name: D-ribose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-ribose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0006015 name: 5-phosphoribose 1-diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] subset: gosubset_prok synonym: "5-phosphoribose 1-diphosphate anabolism" EXACT [] synonym: "5-phosphoribose 1-diphosphate biosynthesis" EXACT [] synonym: "5-phosphoribose 1-diphosphate formation" EXACT [] synonym: "5-phosphoribose 1-diphosphate synthesis" EXACT [] synonym: "5-phosphoribosyl-1-pyrophosphate biosynthesis" EXACT [] synonym: "5-phosphoribosyl-1-pyrophosphate biosynthetic process" EXACT [] synonym: "PRPP biosynthetic process" EXACT [] xref: MetaCyc:PWY0-661 xref: Reactome:1252991 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1326495 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1352602 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1372834 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1392846 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1450408 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1470939 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1482979 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1496751 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1514141 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1520967 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1526719 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1532443 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1535995 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1537995 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1539248 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:1540299 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:73843 "5-Phosphoribose 1-diphosphate biosynthesis" is_a: GO:0046390 ! ribose phosphate biosynthetic process is_a: GO:0046391 ! 5-phosphoribose 1-diphosphate metabolic process [Term] id: GO:0006016 name: 2-deoxyribose 1-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "2-deoxyribose 1-phosphate anabolism" EXACT [] synonym: "2-deoxyribose 1-phosphate biosynthesis" EXACT [] synonym: "2-deoxyribose 1-phosphate formation" EXACT [] synonym: "2-deoxyribose 1-phosphate synthesis" EXACT [] is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process [Term] id: GO:0006017 name: deoxyribose 1,5-bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] subset: gosubset_prok synonym: "deoxyribose 1,5-bisphosphate anabolism" EXACT [] synonym: "deoxyribose 1,5-bisphosphate biosynthesis" EXACT [] synonym: "deoxyribose 1,5-bisphosphate formation" EXACT [] synonym: "deoxyribose 1,5-bisphosphate synthesis" EXACT [] is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process is_a: GO:0046387 ! deoxyribose 1,5-bisphosphate metabolic process [Term] id: GO:0006018 name: 2-deoxyribose 1-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai] subset: gosubset_prok synonym: "2-deoxyribose 1-phosphate breakdown" EXACT [] synonym: "2-deoxyribose 1-phosphate catabolism" EXACT [] synonym: "2-deoxyribose 1-phosphate degradation" EXACT [] synonym: "deoxyribose 1-phosphate catabolic process" EXACT [GOC:mah] is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process is_a: GO:0046386 ! deoxyribose phosphate catabolic process [Term] id: GO:0006019 name: deoxyribose 5-phosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate." [GOC:ai] subset: gosubset_prok is_a: GO:0046389 ! deoxyribose 5-phosphate metabolic process is_a: GO:0046835 ! carbohydrate phosphorylation [Term] id: GO:0006020 name: inositol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684] subset: gosubset_prok synonym: "inositol metabolism" EXACT [] synonym: "myo-inositol metabolic process" NARROW [] synonym: "myo-inositol metabolism" NARROW [] synonym: "vitamin Bh metabolic process" EXACT [] synonym: "vitamin Bh metabolism" EXACT [] xref: Wikipedia:Inositol is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0006021 name: inositol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684] subset: gosubset_prok synonym: "inositol anabolism" EXACT [] synonym: "inositol biosynthesis" EXACT [] synonym: "inositol formation" EXACT [] synonym: "inositol synthesis" EXACT [] synonym: "myo-inositol biosynthesis" NARROW [] synonym: "myo-inositol biosynthetic process" NARROW [] synonym: "vitamin Bh biosynthesis" EXACT [] synonym: "vitamin Bh biosynthetic process" EXACT [] is_a: GO:0006020 ! inositol metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process [Term] id: GO:0006022 name: aminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminoglycan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0006023 name: aminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminoglycan anabolism" EXACT [] synonym: "aminoglycan biosynthesis" EXACT [] synonym: "aminoglycan formation" EXACT [] synonym: "aminoglycan synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] subset: gosubset_prok synonym: "glycosaminoglycan anabolism" EXACT [] synonym: "glycosaminoglycan biosynthesis" EXACT [] synonym: "glycosaminoglycan formation" EXACT [] synonym: "glycosaminoglycan synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006025 name: galactosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] subset: gosubset_prok synonym: "galactosaminoglycan anabolism" EXACT [] synonym: "galactosaminoglycan biosynthesis" EXACT [] synonym: "galactosaminoglycan formation" EXACT [] synonym: "galactosaminoglycan synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0046350 ! galactosaminoglycan metabolic process [Term] id: GO:0006026 name: aminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminoglycan breakdown" EXACT [] synonym: "aminoglycan catabolism" EXACT [] synonym: "aminoglycan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0006027 name: glycosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] subset: gosubset_prok synonym: "glycosaminoglycan breakdown" EXACT [] synonym: "glycosaminoglycan catabolism" EXACT [] synonym: "glycosaminoglycan degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006028 name: galactosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] subset: gosubset_prok synonym: "galactosaminoglycan breakdown" EXACT [] synonym: "galactosaminoglycan catabolism" EXACT [] synonym: "galactosaminoglycan degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0046350 ! galactosaminoglycan metabolic process [Term] id: GO:0006029 name: proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proteoglycan metabolism" EXACT [] synonym: "proteoglycan sulfate transfer" NARROW [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006030 name: chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT [] synonym: "chitin metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0006031 name: chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT [] synonym: "chitin anabolism" EXACT [] synonym: "chitin biosynthesis" EXACT [] synonym: "chitin formation" EXACT [] synonym: "chitin synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0006030 ! chitin metabolic process [Term] id: GO:0006032 name: chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT [] synonym: "chitin breakdown" EXACT [] synonym: "chitin catabolism" EXACT [] synonym: "chitin degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0006030 ! chitin metabolic process [Term] id: GO:0006033 name: chitin localization namespace: biological_process def: "A process in which chitin is transported to, or maintained in, a specific location." [GOC:ai] subset: gosubset_prok synonym: "chitin localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chitin localization" EXACT [] is_a: GO:0033037 ! polysaccharide localization [Term] id: GO:0006034 name: cuticle chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin metabolism" EXACT [] is_a: GO:0006030 ! chitin metabolic process [Term] id: GO:0006035 name: cuticle chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin anabolism" EXACT [] synonym: "cuticle chitin biosynthesis" EXACT [] synonym: "cuticle chitin formation" EXACT [] synonym: "cuticle chitin synthesis" EXACT [] is_a: GO:0006031 ! chitin biosynthetic process is_a: GO:0006034 ! cuticle chitin metabolic process relationship: part_of GO:0040003 ! chitin-based cuticle development [Term] id: GO:0006036 name: cuticle chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin breakdown" EXACT [] synonym: "cuticle chitin catabolism" EXACT [] synonym: "cuticle chitin degradation" EXACT [] is_a: GO:0006032 ! chitin catabolic process is_a: GO:0006034 ! cuticle chitin metabolic process [Term] id: GO:0006037 name: cell wall chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] subset: gosubset_prok synonym: "cell wall chitin metabolism" EXACT [] is_a: GO:0006030 ! chitin metabolic process is_a: GO:0010383 ! cell wall polysaccharide metabolic process [Term] id: GO:0006038 name: cell wall chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] synonym: "cell wall chitin anabolism" EXACT [] synonym: "cell wall chitin biosynthesis" EXACT [] synonym: "cell wall chitin formation" EXACT [] synonym: "cell wall chitin synthesis" EXACT [] is_a: GO:0006031 ! chitin biosynthetic process is_a: GO:0006037 ! cell wall chitin metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process [Term] id: GO:0006039 name: cell wall chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] subset: gosubset_prok synonym: "cell wall chitin breakdown" EXACT [] synonym: "cell wall chitin catabolism" EXACT [] synonym: "cell wall chitin degradation" EXACT [] is_a: GO:0006032 ! chitin catabolic process is_a: GO:0006037 ! cell wall chitin metabolic process is_a: GO:0016998 ! cell wall macromolecule catabolic process [Term] id: GO:0006040 name: amino sugar metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "amino sugar metabolism" EXACT [] synonym: "aminosaccharide metabolic process" EXACT [] synonym: "aminosaccharide metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0006041 name: glucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chitosamine metabolic process" EXACT [] synonym: "chitosamine metabolism" EXACT [] synonym: "glucosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process [Term] id: GO:0006042 name: glucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chitosamine biosynthesis" EXACT [] synonym: "chitosamine biosynthetic process" EXACT [] synonym: "glucosamine anabolism" EXACT [] synonym: "glucosamine biosynthesis" EXACT [] synonym: "glucosamine formation" EXACT [] synonym: "glucosamine synthesis" EXACT [] is_a: GO:0006041 ! glucosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0006043 name: glucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chitosamine catabolic process" EXACT [] synonym: "chitosamine catabolism" EXACT [] synonym: "glucosamine breakdown" EXACT [] synonym: "glucosamine catabolism" EXACT [] synonym: "glucosamine degradation" EXACT [] xref: MetaCyc:GLUAMCAT-PWY is_a: GO:0006041 ! glucosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0006044 name: N-acetylglucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylglucosamine metabolism" EXACT [] is_a: GO:0006041 ! glucosamine metabolic process [Term] id: GO:0006045 name: N-acetylglucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylglucosamine anabolism" EXACT [] synonym: "N-acetylglucosamine biosynthesis" EXACT [] synonym: "N-acetylglucosamine formation" EXACT [] synonym: "N-acetylglucosamine synthesis" EXACT [] is_a: GO:0006042 ! glucosamine biosynthetic process is_a: GO:0006044 ! N-acetylglucosamine metabolic process [Term] id: GO:0006046 name: N-acetylglucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylglucosamine breakdown" EXACT [] synonym: "N-acetylglucosamine catabolism" EXACT [] synonym: "N-acetylglucosamine degradation" EXACT [] is_a: GO:0006043 ! glucosamine catabolic process is_a: GO:0006044 ! N-acetylglucosamine metabolic process [Term] id: GO:0006047 name: UDP-N-acetylglucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-N-acetylglucosamine metabolism" EXACT [] is_a: GO:0006044 ! N-acetylglucosamine metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0006048 name: UDP-N-acetylglucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-GlcNAc biosynthesis" EXACT [] synonym: "UDP-GlcNAc biosynthetic process" EXACT [] synonym: "UDP-N-acetylglucosamine anabolism" EXACT [] synonym: "UDP-N-acetylglucosamine biosynthesis" EXACT [] synonym: "UDP-N-acetylglucosamine formation" EXACT [] synonym: "UDP-N-acetylglucosamine synthesis" EXACT [] xref: MetaCyc:UDPNAGSYN-PWY xref: Reactome:446210 "Synthesis of UDP-N-acetyl-glucosamine" is_a: GO:0006045 ! N-acetylglucosamine biosynthetic process is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process [Term] id: GO:0006049 name: UDP-N-acetylglucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-N-acetylglucosamine breakdown" EXACT [] synonym: "UDP-N-acetylglucosamine catabolism" EXACT [] synonym: "UDP-N-acetylglucosamine degradation" EXACT [] is_a: GO:0006046 ! N-acetylglucosamine catabolic process is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process [Term] id: GO:0006050 name: mannosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [CHEBI:mannosamine, GOC:curators] subset: gosubset_prok synonym: "mannosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process [Term] id: GO:0006051 name: N-acetylmannosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylmannosamine metabolism" EXACT [] is_a: GO:0006050 ! mannosamine metabolic process [Term] id: GO:0006052 name: N-acetylmannosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylmannosamine anabolism" EXACT [] synonym: "N-acetylmannosamine biosynthesis" EXACT [] synonym: "N-acetylmannosamine formation" EXACT [] synonym: "N-acetylmannosamine synthesis" EXACT [] is_a: GO:0006051 ! N-acetylmannosamine metabolic process is_a: GO:0046347 ! mannosamine biosynthetic process [Term] id: GO:0006053 name: N-acetylmannosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylmannosamine breakdown" EXACT [] synonym: "N-acetylmannosamine catabolism" EXACT [] synonym: "N-acetylmannosamine degradation" EXACT [] is_a: GO:0006051 ! N-acetylmannosamine metabolic process is_a: GO:0046346 ! mannosamine catabolic process [Term] id: GO:0006054 name: N-acetylneuraminate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylneuraminate metabolism" EXACT [] synonym: "sialic acid metabolic process" BROAD [] synonym: "sialic acid metabolism" BROAD [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0006055 name: CMP-N-acetylneuraminate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] subset: gosubset_prok synonym: "CMP-N-acetylneuraminate anabolism" EXACT [] synonym: "CMP-N-acetylneuraminate biosynthesis" EXACT [] synonym: "CMP-N-acetylneuraminate formation" EXACT [] synonym: "CMP-N-acetylneuraminate synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046380 ! N-acetylneuraminate biosynthetic process is_a: GO:0046381 ! CMP-N-acetylneuraminate metabolic process [Term] id: GO:0006056 name: mannoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannoprotein metabolism" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006057 name: mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannoprotein anabolism" EXACT [] synonym: "mannoprotein biosynthesis" EXACT [] synonym: "mannoprotein formation" EXACT [] synonym: "mannoprotein synthesis" EXACT [] is_a: GO:0006056 ! mannoprotein metabolic process is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0006058 name: mannoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannoprotein breakdown" EXACT [] synonym: "mannoprotein catabolism" EXACT [] synonym: "mannoprotein degradation" EXACT [] is_a: GO:0006056 ! mannoprotein metabolic process is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0006059 name: hexitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hexitol metabolism" EXACT [] synonym: "sugar alcohol (hexitol) metabolic process" EXACT [] synonym: "sugar alcohol (hexitol) metabolism" EXACT [] is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0006060 name: sorbitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sorbitol metabolism" EXACT [] xref: MetaCyc:P461-PWY is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0006061 name: sorbitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sorbitol anabolism" EXACT [] synonym: "sorbitol biosynthesis" EXACT [] synonym: "sorbitol formation" EXACT [] synonym: "sorbitol synthesis" EXACT [] is_a: GO:0006060 ! sorbitol metabolic process is_a: GO:0019406 ! hexitol biosynthetic process [Term] id: GO:0006062 name: sorbitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sorbitol breakdown" EXACT [] synonym: "sorbitol catabolism" EXACT [] synonym: "sorbitol degradation" EXACT [] xref: MetaCyc:SORBDEG-PWY is_a: GO:0006060 ! sorbitol metabolic process is_a: GO:0019407 ! hexitol catabolic process [Term] id: GO:0006063 name: uronic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "uronic acid metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006064 name: glucuronate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glucuronate breakdown" EXACT [] synonym: "glucuronate catabolism" EXACT [] synonym: "glucuronate degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0019585 ! glucuronate metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0006065 name: UDP-glucuronate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-glucuronate anabolism" EXACT [] synonym: "UDP-glucuronate biosynthesis" EXACT [] synonym: "UDP-glucuronate formation" EXACT [] synonym: "UDP-glucuronate synthesis" EXACT [] xref: MetaCyc:PWY-4841 xref: Reactome:1252916 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1279850 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1298765 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1326419 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1352535 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1372763 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1392773 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1417250 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1450338 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1470879 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1482911 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1496707 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1514098 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1520923 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1526669 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1532396 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1539325 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:1540335 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:173599 "Formation of the active cofactor, UDP-glucuronate" is_a: GO:0046398 ! UDP-glucuronate metabolic process is_a: GO:0046399 ! glucuronate biosynthetic process [Term] id: GO:0006066 name: alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "alcohol metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006067 name: ethanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ethanol metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0006068 name: ethanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ethanol breakdown" EXACT [] synonym: "ethanol catabolism" EXACT [] synonym: "ethanol degradation" EXACT [] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0034310 ! primary alcohol catabolic process [Term] id: GO:0006069 name: ethanol oxidation namespace: biological_process def: "An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah, MetaCyc:PWY66-161, MetaCyc:PWY66-162, MetaCyc:PWY66-21] subset: gosubset_prok xref: Reactome:1252962 "Ethanol oxidation" xref: Reactome:1279892 "Ethanol oxidation" xref: Reactome:1298803 "Ethanol oxidation" xref: Reactome:1326465 "Ethanol oxidation" xref: Reactome:1352579 "Ethanol oxidation" xref: Reactome:1372807 "Ethanol oxidation" xref: Reactome:1392819 "Ethanol oxidation" xref: Reactome:1417292 "Ethanol oxidation" xref: Reactome:1450382 "Ethanol oxidation" xref: Reactome:1470909 "Ethanol oxidation" xref: Reactome:1482949 "Ethanol oxidation" xref: Reactome:1496734 "Ethanol oxidation" xref: Reactome:1514124 "Ethanol oxidation" xref: Reactome:1526699 "Ethanol oxidation" xref: Reactome:1532425 "Ethanol oxidation" xref: Reactome:1539243 "Ethanol oxidation" xref: Reactome:71384 "Ethanol oxidation" is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006070 name: octanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:go_curators] subset: gosubset_prok synonym: "octanol metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0006071 name: glycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerol metabolism" EXACT [] xref: MetaCyc:GLYCEROLMETAB-PWY is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0006072 name: glycerol-3-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerol-3-phosphate metabolism" EXACT [] is_a: GO:0006071 ! glycerol metabolic process is_a: GO:0006796 ! phosphate metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0006073 name: cellular glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [ISBN:0198547684] subset: gosubset_prok synonym: "cellular glucan metabolism" EXACT [] is_a: GO:0044042 ! glucan metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0006074 name: 1,3-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "1,3-beta-glucan metabolic process" BROAD [GOC:tb] synonym: "1,3-beta-glucan metabolism" EXACT [] synonym: "beta-1,3 glucan metabolic process" EXACT [] synonym: "beta-1,3 glucan metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0006075 name: 1,3-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds." [GOC:ai] synonym: "1,3-beta-glucan anabolism" EXACT [] synonym: "1,3-beta-glucan biosynthesis" EXACT [] synonym: "1,3-beta-glucan biosynthetic process" BROAD [GOC:tb] synonym: "1,3-beta-glucan formation" EXACT [] synonym: "1,3-beta-glucan synthesis" EXACT [] synonym: "beta-1,3 glucan anabolism" EXACT [] synonym: "beta-1,3 glucan biosynthesis" EXACT [] synonym: "beta-1,3 glucan biosynthetic process" EXACT [] synonym: "beta-1,3 glucan formation" EXACT [] synonym: "beta-1,3 glucan synthesis" EXACT [] is_a: GO:0006074 ! 1,3-beta-D-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0006076 name: 1,3-beta-D-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-1,3 glucans." [GOC:ai] subset: gosubset_prok synonym: "1,3-beta-glucan breakdown" EXACT [] synonym: "1,3-beta-glucan catabolic process" BROAD [GOC:tb] synonym: "1,3-beta-glucan catabolism" EXACT [] synonym: "1,3-beta-glucan degradation" EXACT [] synonym: "beta-1,3 glucan breakdown" EXACT [] synonym: "beta-1,3 glucan catabolic process" EXACT [] synonym: "beta-1,3 glucan catabolism" EXACT [] synonym: "beta-1,3 glucan degradation" EXACT [] is_a: GO:0006074 ! 1,3-beta-D-glucan metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0006077 name: 1,6-beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,6 glucans, compounds composed of glucose residues linked by 1,6-beta-D-glucosidic bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "1,6-beta-glucan metabolism" EXACT [] synonym: "beta-1,6 glucan metabolic process" EXACT [] synonym: "beta-1,6 glucan metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0006078 name: 1,6-beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-1,6 glucans." [GOC:ai] synonym: "1,6-beta-glucan anabolism" EXACT [] synonym: "1,6-beta-glucan biosynthesis" EXACT [] synonym: "1,6-beta-glucan formation" EXACT [] synonym: "1,6-beta-glucan synthesis" EXACT [] synonym: "beta-1,6 glucan anabolism" EXACT [] synonym: "beta-1,6 glucan biosynthesis" EXACT [] synonym: "beta-1,6 glucan biosynthetic process" EXACT [] synonym: "beta-1,6 glucan formation" EXACT [] synonym: "beta-1,6 glucan synthesis" EXACT [] is_a: GO:0006077 ! 1,6-beta-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0006079 name: 1,6-beta-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-1,6 glucans." [GOC:ai] subset: gosubset_prok synonym: "1,6-beta-glucan breakdown" EXACT [] synonym: "1,6-beta-glucan catabolism" EXACT [] synonym: "1,6-beta-glucan degradation" EXACT [] synonym: "beta-1,6 glucan breakdown" EXACT [] synonym: "beta-1,6 glucan catabolic process" EXACT [] synonym: "beta-1,6 glucan catabolism" EXACT [] synonym: "beta-1,6 glucan degradation" EXACT [] is_a: GO:0006077 ! 1,6-beta-glucan metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0006080 name: substituted mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units." [GOC:tair_curators] subset: gosubset_prok synonym: "substituted mannan metabolism" EXACT [] is_a: GO:0010412 ! mannan metabolic process [Term] id: GO:0006081 name: cellular aldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "aldehyde metabolism" EXACT [] synonym: "alkanal metabolic process" EXACT [] synonym: "alkanal metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "organic acid metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006083 name: acetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators] subset: gosubset_prok synonym: "acetate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006084 name: acetyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684] subset: gosubset_prok synonym: "acetyl coenzyme A metabolic process" EXACT [] synonym: "acetyl coenzyme A metabolism" EXACT [] synonym: "acetyl-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0006085 name: acetyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators] subset: gosubset_prok synonym: "acetyl-CoA anabolism" EXACT [] synonym: "acetyl-CoA biosynthesis" EXACT [] synonym: "acetyl-CoA formation" EXACT [] synonym: "acetyl-CoA synthesis" EXACT [] xref: MetaCyc:PWY-5173 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process [Term] id: GO:0006086 name: acetyl-CoA biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "acetyl-CoA anabolism from pyruvate" EXACT [] synonym: "acetyl-CoA formation from pyruvate" EXACT [] synonym: "acetyl-CoA synthesis from pyruvate" EXACT [] synonym: "pyruvate dehydrogenase pathway" EXACT [] xref: MetaCyc:PYRUVDEHYD-PWY is_a: GO:0006085 ! acetyl-CoA biosynthetic process is_a: GO:0006090 ! pyruvate metabolic process [Term] id: GO:0006088 name: acetate to acetyl-CoA namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0003987 [Term] id: GO:0006089 name: lactate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684] subset: gosubset_prok synonym: "2-hydroxypropanoate metabolic process" EXACT [] synonym: "2-hydroxypropanoate metabolism" EXACT [] synonym: "alpha-hydroxypropionate metabolic process" EXACT [] synonym: "alpha-hydroxypropionate metabolism" EXACT [] synonym: "lactate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006090 name: pyruvate metabolic process namespace: biological_process alt_id: GO:0006087 def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] subset: gosubset_prok synonym: "pyruvate dehydrogenase bypass" RELATED [] synonym: "pyruvate metabolism" EXACT [] xref: MetaCyc:P41-PWY xref: Reactome:1252929 "Pyruvate metabolism" xref: Reactome:1279863 "Pyruvate metabolism" xref: Reactome:1298777 "Pyruvate metabolism" xref: Reactome:1326432 "Pyruvate metabolism" xref: Reactome:1352548 "Pyruvate metabolism" xref: Reactome:1372775 "Pyruvate metabolism" xref: Reactome:1392785 "Pyruvate metabolism" xref: Reactome:1417262 "Pyruvate metabolism" xref: Reactome:1450351 "Pyruvate metabolism" xref: Reactome:1482946 "Pyruvate metabolism" xref: Reactome:1496731 "Pyruvate metabolism" xref: Reactome:1514121 "Pyruvate metabolism" xref: Reactome:1520948 "Pyruvate metabolism" xref: Reactome:1526696 "Pyruvate metabolism" xref: Reactome:1532408 "Pyruvate metabolism" xref: Reactome:1535968 "Pyruvate metabolism" xref: Reactome:1540285 "Pyruvate metabolism" xref: Reactome:70268 "Pyruvate metabolism" xref: Wikipedia:Pyruvic_acid is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006094 name: gluconeogenesis namespace: biological_process def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] subset: gosubset_prok synonym: "glucose biosynthesis" EXACT [] synonym: "glucose biosynthetic process" EXACT [] xref: MetaCyc:GLUCONEO-PWY xref: Reactome:1252912 "Gluconeogenesis" xref: Reactome:1279846 "Gluconeogenesis" xref: Reactome:1298761 "Gluconeogenesis" xref: Reactome:1326415 "Gluconeogenesis" xref: Reactome:1352531 "Gluconeogenesis" xref: Reactome:1372759 "Gluconeogenesis" xref: Reactome:1392769 "Gluconeogenesis" xref: Reactome:1417246 "Gluconeogenesis" xref: Reactome:1450334 "Gluconeogenesis" xref: Reactome:1470875 "Gluconeogenesis" xref: Reactome:1482907 "Gluconeogenesis" xref: Reactome:1496703 "Gluconeogenesis" xref: Reactome:1514094 "Gluconeogenesis" xref: Reactome:1520919 "Gluconeogenesis" xref: Reactome:1526665 "Gluconeogenesis" xref: Reactome:1532392 "Gluconeogenesis" xref: Reactome:1535967 "Gluconeogenesis" xref: Reactome:1537974 "Gluconeogenesis" xref: Reactome:1539220 "Gluconeogenesis" xref: Reactome:1540277 "Gluconeogenesis" xref: Reactome:70263 "Gluconeogenesis" xref: Wikipedia:Gluconeogenesis is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0006096 name: glycolysis namespace: biological_process alt_id: GO:0019641 alt_id: GO:0019642 def: "The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [ISBN:0716720094] subset: gosubset_prok synonym: "anaerobic glycolysis" RELATED [] synonym: "Embden-Meyerhof pathway" EXACT [] synonym: "Embden-Meyerhof-Parnas pathway" EXACT [] synonym: "modifed Embden-Meyerhof pathway" RELATED [] xref: MetaCyc:ANAGLYCOLYSIS-PWY xref: MetaCyc:GLYCOLYSIS xref: MetaCyc:P341-PWY xref: MetaCyc:PWY-1042 xref: MetaCyc:PWY-5484 xref: Reactome:1252928 "Glycolysis" xref: Reactome:1279862 "Glycolysis" xref: Reactome:1298776 "Glycolysis" xref: Reactome:1326431 "Glycolysis" xref: Reactome:1352547 "Glycolysis" xref: Reactome:1372774 "Glycolysis" xref: Reactome:1392784 "Glycolysis" xref: Reactome:1417261 "Glycolysis" xref: Reactome:1450350 "Glycolysis" xref: Reactome:1470891 "Glycolysis" xref: Reactome:1482923 "Glycolysis" xref: Reactome:1496719 "Glycolysis" xref: Reactome:1514110 "Glycolysis" xref: Reactome:1520930 "Glycolysis" xref: Reactome:1526680 "Glycolysis" xref: Reactome:1532407 "Glycolysis" xref: Reactome:1535966 "Glycolysis" xref: Reactome:1537973 "Glycolysis" xref: Reactome:1539227 "Glycolysis" xref: Reactome:1540284 "Glycolysis" xref: Reactome:70171 "Glycolysis" xref: Wikipedia:Glycolysis is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006091 ! generation of precursor metabolites and energy [Term] id: GO:0006097 name: glyoxylate cycle namespace: biological_process def: "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glyoxylate bypass" EXACT [] xref: MetaCyc:GLYOXYLATE-BYPASS xref: Wikipedia:Glyoxylate_cycle is_a: GO:0044262 ! cellular carbohydrate metabolic process is_a: GO:0046487 ! glyoxylate metabolic process [Term] id: GO:0006098 name: pentose-phosphate shunt namespace: biological_process def: "The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:PENTOSE-P-PWY] subset: gosubset_prok synonym: "hexose monophosphate pathway" EXACT [] synonym: "pentose phosphate pathway" EXACT [] synonym: "pentose phosphate shunt" EXACT [] synonym: "pentose-phosphate pathway" EXACT [] xref: MetaCyc:PENTOSE-P-PWY xref: Reactome:1252922 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1279856 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1298800 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1326425 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1352541 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1372804 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1392814 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1417287 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1450344 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1470885 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1482917 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1496713 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1514104 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1520947 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1526674 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1532401 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1535977 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1537971 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1539225 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:1540282 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:71336 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Wikipedia:Pentose_phosphate_pathway is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006740 ! NADPH regeneration [Term] id: GO:0006099 name: tricarboxylic acid cycle namespace: biological_process def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "citric acid cycle" EXACT [] synonym: "Krebs cycle" EXACT [] synonym: "TCA cycle" EXACT [] xref: MetaCyc:P105-PWY xref: MetaCyc:P42-PWY xref: MetaCyc:TCA xref: Reactome:1252945 "Citric acid cycle (TCA cycle)" xref: Reactome:1279879 "Citric acid cycle (TCA cycle)" xref: Reactome:1298791 "Citric acid cycle (TCA cycle)" xref: Reactome:1326448 "Citric acid cycle (TCA cycle)" xref: Reactome:1352564 "Citric acid cycle (TCA cycle)" xref: Reactome:1372791 "Citric acid cycle (TCA cycle)" xref: Reactome:1392801 "Citric acid cycle (TCA cycle)" xref: Reactome:1417278 "Citric acid cycle (TCA cycle)" xref: Reactome:1450367 "Citric acid cycle (TCA cycle)" xref: Reactome:1470904 "Citric acid cycle (TCA cycle)" xref: Reactome:1482937 "Citric acid cycle (TCA cycle)" xref: Reactome:1496727 "Citric acid cycle (TCA cycle)" xref: Reactome:1514117 "Citric acid cycle (TCA cycle)" xref: Reactome:1520939 "Citric acid cycle (TCA cycle)" xref: Reactome:1526692 "Citric acid cycle (TCA cycle)" xref: Reactome:1532421 "Citric acid cycle (TCA cycle)" xref: Reactome:1535974 "Citric acid cycle (TCA cycle)" xref: Reactome:1537983 "Citric acid cycle (TCA cycle)" xref: Reactome:1539234 "Citric acid cycle (TCA cycle)" xref: Reactome:1540292 "Citric acid cycle (TCA cycle)" xref: Reactome:71403 "Citric acid cycle (TCA cycle)" xref: Wikipedia:Tricarboxylic_acid_cycle is_a: GO:0046356 ! acetyl-CoA catabolic process relationship: part_of GO:0009060 ! aerobic respiration [Term] id: GO:0006100 name: tricarboxylic acid cycle intermediate metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle." [GOC:ai] comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. synonym: "citric acid cycle intermediate metabolic process" EXACT [] synonym: "citric acid cycle intermediate metabolism" EXACT [] synonym: "Krebs cycle intermediate metabolic process" EXACT [] synonym: "Krebs cycle intermediate metabolism" EXACT [] synonym: "TCA intermediate metabolic process" EXACT [] synonym: "TCA intermediate metabolism" EXACT [] synonym: "tricarboxylic acid cycle intermediate metabolism" EXACT [] is_obsolete: true consider: GO:0006099 consider: GO:0006101 consider: GO:0006103 consider: GO:0006104 consider: GO:0006105 consider: GO:0006106 consider: GO:0006107 consider: GO:0006108 [Term] id: GO:0006101 name: citrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "citrate metabolism" EXACT [] is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] id: GO:0006102 name: isocitrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "isocitrate metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0006103 name: 2-oxoglutarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "2-ketoglutarate metabolic process" EXACT [] synonym: "2-ketoglutarate metabolism" EXACT [] synonym: "2-oxoglutarate metabolism" EXACT [] synonym: "alpha-ketoglutarate metabolic process" EXACT [] synonym: "alpha-ketoglutarate metabolism" EXACT [] synonym: "alpha-oxoglutarate metabolic process" EXACT [] synonym: "alpha-oxoglutarate metabolism" EXACT [] xref: Reactome:880009 "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006104 name: succinyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai] subset: gosubset_prok synonym: "succinyl-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0006105 name: succinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "succinate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006106 name: fumarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fumarate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006107 name: oxaloacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oxaloacetate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006108 name: malate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "malate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of carbohydrate metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0006110 name: regulation of glycolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators] subset: gosubset_prok is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process relationship: regulates GO:0006096 ! glycolysis [Term] id: GO:0006111 name: regulation of gluconeogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of glucose biosynthesis" BROAD [] synonym: "regulation of glucose biosynthetic process" BROAD [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process relationship: regulates GO:0006094 ! gluconeogenesis [Term] id: GO:0006112 name: energy reserve metabolic process namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "energy reserve metabolism" EXACT [] xref: Reactome:1253202 "Integration of energy metabolism" xref: Reactome:1280136 "Integration of energy metabolism" xref: Reactome:1299016 "Integration of energy metabolism" xref: Reactome:1326708 "Integration of energy metabolism" xref: Reactome:1352820 "Integration of energy metabolism" xref: Reactome:1373029 "Integration of energy metabolism" xref: Reactome:1393046 "Integration of energy metabolism" xref: Reactome:1417522 "Integration of energy metabolism" xref: Reactome:1450618 "Integration of energy metabolism" xref: Reactome:1471120 "Integration of energy metabolism" xref: Reactome:1483179 "Integration of energy metabolism" xref: Reactome:1496882 "Integration of energy metabolism" xref: Reactome:1514275 "Integration of energy metabolism" xref: Reactome:1521080 "Integration of energy metabolism" xref: Reactome:1526858 "Integration of energy metabolism" xref: Reactome:1532585 "Integration of energy metabolism" xref: Reactome:1536065 "Integration of energy metabolism" xref: Reactome:1538039 "Integration of energy metabolism" xref: Reactome:1539322 "Integration of energy metabolism" xref: Reactome:1540334 "Integration of energy metabolism" xref: Reactome:163685 "Integration of energy metabolism" is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006113 name: fermentation namespace: biological_process def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:curators, MetaCyc:Fermentation] subset: goslim_pir subset: gosubset_prok xref: MetaCyc:FERMENTATION-PWY xref: Wikipedia:Fermentation_(biochemistry) is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006114 name: glycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerol anabolism" EXACT [] synonym: "glycerol biosynthesis" EXACT [] synonym: "glycerol formation" EXACT [] synonym: "glycerol synthesis" EXACT [] is_a: GO:0006071 ! glycerol metabolic process is_a: GO:0019401 ! alditol biosynthetic process relationship: part_of GO:0006113 ! fermentation [Term] id: GO:0006115 name: ethanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ethanol anabolism" EXACT [] synonym: "ethanol biosynthesis" EXACT [] synonym: "ethanol formation" EXACT [] synonym: "ethanol synthesis" EXACT [] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0006116 name: NADH oxidation namespace: biological_process def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD." [GOC:ai] subset: gosubset_prok synonym: "NAD (reduced) dehydrogenation" EXACT [] synonym: "NAD (reduced) oxidation" EXACT [] synonym: "NADH dehydrogenation" EXACT [] synonym: "reduced NAD dehydrogenation" EXACT [] synonym: "reduced NAD oxidation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT [] is_a: GO:0006734 ! NADH metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006117 name: acetaldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [CHEBI:15343, GOC:go_curators] subset: gosubset_prok synonym: "acetaldehyde metabolism" EXACT [] synonym: "ethanal metabolic process" EXACT [] synonym: "ethanal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process [Term] id: GO:0006118 name: electron transport namespace: biological_process def: "OBSOLETE. The transport of electrons from an electron donor to an electron acceptor." [GOC:curators] comment: This term was made obsolete because it describes a molecular function. synonym: "6-phosphofructokinase reduction" RELATED [] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "dihydrolipoamide reduction" RELATED [] synonym: "dihydrolipoylprotein reduction" RELATED [] synonym: "dihydropteridine reduction" RELATED [] synonym: "electron transfer" EXACT [] synonym: "other pathways of electron transport" RELATED [] synonym: "oxidized glutathione reduction" RELATED [] synonym: "protein-disulfide reduction" RELATED [] is_obsolete: true replaced_by: GO:0055114 consider: GO:0016491 consider: GO:0022904 [Term] id: GO:0006119 name: oxidative phosphorylation namespace: biological_process def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0471331309 "Biochemical Pathways"] subset: goslim_pir subset: gosubset_prok synonym: "respiratory-chain phosphorylation" EXACT [] xref: Wikipedia:Oxidative_phosphorylation is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0016310 ! phosphorylation [Term] id: GO:0006120 name: mitochondrial electron transport, NADH to ubiquinone namespace: biological_process def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] synonym: "complex I (NADH to ubiquinone)" RELATED [] synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT [] xref: Reactome:1233380 "NADH enters the respiratory chain at Complex I" xref: Reactome:1261039 "NADH enters the respiratory chain at Complex I" xref: Reactome:1286035 "NADH enters the respiratory chain at Complex I" xref: Reactome:1306984 "NADH enters the respiratory chain at Complex I" xref: Reactome:1334522 "NADH enters the respiratory chain at Complex I" xref: Reactome:1358777 "NADH enters the respiratory chain at Complex I" xref: Reactome:1427964 "NADH enters the respiratory chain at Complex I" xref: Reactome:1457960 "NADH enters the respiratory chain at Complex I" xref: Reactome:163217 "NADH enters the respiratory chain at Complex I" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006121 name: mitochondrial electron transport, succinate to ubiquinone namespace: biological_process def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363] synonym: "complex II (succinate to ubiquinone)" RELATED [] synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT [] synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT [] xref: Reactome:1233182 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1306772 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1334302 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1358582 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1379584 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1400124 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1427706 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1457722 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1475926 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1517737 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1524368 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:1530211 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:163213 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:165642 "Transfer of electrons through the bovine succinate dehydrogenase complex" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006122 name: mitochondrial electron transport, ubiquinol to cytochrome c namespace: biological_process def: "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] synonym: "complex III (ubiquinone to cytochrome c)" RELATED [] xref: Reactome:1307269 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:1358999 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:1379878 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:1428220 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:164651 "Electron transfer from ubiquinol to cytochrome c of complex III" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006123 name: mitochondrial electron transport, cytochrome c to oxygen namespace: biological_process def: "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363] synonym: "complex IV (reduction of O2)" RELATED [] xref: Reactome:1306823 "Electron transfer from reduced cytochrome c to molecular oxygen" xref: Reactome:1358622 "Electron transfer from reduced cytochrome c to molecular oxygen" xref: Reactome:1427771 "Electron transfer from reduced cytochrome c to molecular oxygen" xref: Reactome:163214 "Electron transfer from reduced cytochrome c to molecular oxygen" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006124 name: ferredoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ferredoxin metabolism" EXACT [] is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006125 name: thioredoxin pathway namespace: biological_process def: "OBSOLETE." [GOC:mtg_electron_transport] comment: This term was made obsolete because it is not clear what it is intended to represent. synonym: "thioredoxin reduction" NARROW [] xref: MetaCyc:THIOREDOX-PWY is_obsolete: true consider: GO:0045454 [Term] id: GO:0006126 name: other pathways of electron transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true replaced_by: GO:0022900 [Term] id: GO:0006127 name: glycerophosphate shuttle namespace: biological_process def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:071672009] subset: gosubset_prok is_a: GO:0006839 ! mitochondrial transport relationship: part_of GO:0022904 ! respiratory electron transport chain [Term] id: GO:0006128 name: oxidized glutathione reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string represents a molecular function and not a biological pathway. is_obsolete: true consider: GO:0004362 consider: GO:0006749 consider: GO:0022900 [Term] id: GO:0006129 name: protein-disulfide reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "protein-disulphide reduction" EXACT [] is_obsolete: true consider: GO:0019153 consider: GO:0022900 [Term] id: GO:0006130 name: 6-phosphofructokinase reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string was ambiguous and the term may represent a molecular function. is_obsolete: true consider: GO:0003872 consider: GO:0022900 [Term] id: GO:0006131 name: dihydrolipoamide reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004148 consider: GO:0022900 consider: GO:0051068 [Term] id: GO:0006132 name: dihydrolipoylprotein reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004148 consider: GO:0022900 [Term] id: GO:0006133 name: 5,10-methylenetetrahydrofolate oxidation namespace: biological_process def: "OBSOLETE." [GOC:mtg_electron_transport] comment: This term was made obsolete because it is defined as a function term and is in the process ontology. is_obsolete: true consider: GO:0004487 consider: GO:0004488 consider: GO:0004489 consider: GO:0033738 [Term] id: GO:0006134 name: dihydrobiopterin reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0022900 consider: GO:0047040 consider: GO:0051066 [Term] id: GO:0006135 name: dihydropteridine reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004155 consider: GO:0022900 consider: GO:0051067 [Term] id: GO:0006139 name: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process [Term] id: GO:0006140 name: regulation of nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of nucleotide metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0006141 name: regulation of purine base metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of purine base metabolism" EXACT [] synonym: "regulation of purine nucleobase metabolic process" EXACT [CHEBI:26386] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: regulates GO:0006144 ! purine base metabolic process [Term] id: GO:0006142 name: regulation of pyrimidine base metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidines." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of pyrimidine base metabolism" EXACT [] synonym: "regulation of pyrimidine nucleobase metabolic process" EXACT [CHEBI:26432] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: regulates GO:0006206 ! pyrimidine base metabolic process [Term] id: GO:0006143 name: purine metabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more appropriate terms were created. is_obsolete: true consider: GO:0006144 consider: GO:0006163 consider: GO:0042278 [Term] id: GO:0006144 name: purine base metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] subset: gosubset_prok synonym: "purine base metabolism" EXACT [] synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] synonym: "purine nucleobase metabolic process" EXACT [CHEBI:26386] xref: Reactome:1252959 "Purine metabolism" xref: Reactome:1279889 "Purine metabolism" xref: Reactome:1298826 "Purine metabolism" xref: Reactome:1326462 "Purine metabolism" xref: Reactome:1352611 "Purine metabolism" xref: Reactome:1372842 "Purine metabolism" xref: Reactome:1392816 "Purine metabolism" xref: Reactome:1417289 "Purine metabolism" xref: Reactome:1450419 "Purine metabolism" xref: Reactome:1470948 "Purine metabolism" xref: Reactome:1482988 "Purine metabolism" xref: Reactome:1496760 "Purine metabolism" xref: Reactome:1514150 "Purine metabolism" xref: Reactome:1520976 "Purine metabolism" xref: Reactome:1526727 "Purine metabolism" xref: Reactome:1532452 "Purine metabolism" xref: Reactome:1535997 "Purine metabolism" xref: Reactome:1537998 "Purine metabolism" xref: Reactome:1539251 "Purine metabolism" xref: Reactome:1540302 "Purine metabolism" xref: Reactome:73847 "Purine metabolism" is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0006145 name: purine base catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] subset: gosubset_prok synonym: "purine base breakdown" EXACT [] synonym: "purine base catabolism" EXACT [] synonym: "purine base degradation" EXACT [] synonym: "purine nucleobase catabolic process" EXACT [CHEBI:26386] is_a: GO:0006144 ! purine base metabolic process is_a: GO:0046113 ! nucleobase catabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0006146 name: adenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "adenine breakdown" EXACT [] synonym: "adenine catabolism" EXACT [] synonym: "adenine degradation" EXACT [] is_a: GO:0006145 ! purine base catabolic process is_a: GO:0046083 ! adenine metabolic process [Term] id: GO:0006147 name: guanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] subset: gosubset_prok synonym: "guanine breakdown" EXACT [] synonym: "guanine catabolism" EXACT [] synonym: "guanine degradation" EXACT [] is_a: GO:0006145 ! purine base catabolic process is_a: GO:0046098 ! guanine metabolic process [Term] id: GO:0006148 name: inosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] subset: gosubset_prok synonym: "inosine breakdown" EXACT [] synonym: "inosine catabolism" EXACT [] synonym: "inosine degradation" EXACT [] is_a: GO:0046102 ! inosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0006149 name: deoxyinosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyinosine breakdown" EXACT [] synonym: "deoxyinosine catabolism" EXACT [] synonym: "deoxyinosine degradation" EXACT [] is_a: GO:0046094 ! deoxyinosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006150 name: hypoxanthine oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine to xanthine and thence to uric acid." [GOC:mah, PMID:3196295] subset: gosubset_prok is_a: GO:0009114 ! hypoxanthine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006151 name: xanthine oxidation namespace: biological_process def: "The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:jl] subset: gosubset_prok is_a: GO:0009115 ! xanthine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006152 name: purine nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] subset: gosubset_prok synonym: "purine nucleoside breakdown" EXACT [] synonym: "purine nucleoside catabolism" EXACT [] synonym: "purine nucleoside degradation" EXACT [] is_a: GO:0009164 ! nucleoside catabolic process is_a: GO:0042278 ! purine nucleoside metabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0006153 name: purine nucleosidase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0008477 [Term] id: GO:0006154 name: adenosine catabolic process namespace: biological_process alt_id: GO:0006156 def: "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] subset: gosubset_prok synonym: "adenosine breakdown" EXACT [] synonym: "adenosine catabolism" EXACT [] synonym: "adenosine degradation" EXACT [] synonym: "adenosine phosphorolysis" RELATED [] is_a: GO:0046085 ! adenosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0006155 name: adenosine deaminase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0004000 [Term] id: GO:0006157 name: deoxyadenosine catabolic process namespace: biological_process alt_id: GO:0006159 def: "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyadenosine breakdown" EXACT [] synonym: "deoxyadenosine catabolism" EXACT [] synonym: "deoxyadenosine degradation" EXACT [] synonym: "deoxyadenosine phosphorolysis" RELATED [] is_a: GO:0046090 ! deoxyadenosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006158 name: deoxyadenosine deaminase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0046936 [Term] id: GO:0006161 name: deoxyguanosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [CHEBI:17172, GOC:jl] subset: gosubset_prok synonym: "deoxyguanosine breakdown" EXACT [] synonym: "deoxyguanosine catabolism" EXACT [] synonym: "deoxyguanosine degradation" EXACT [] is_a: GO:0042453 ! deoxyguanosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006162 name: purine/pyrimidine nucleoside diphosphate reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004748 [Term] id: GO:0006163 name: purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] synonym: "purine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0006164 name: purine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleotide anabolism" EXACT [] synonym: "purine nucleotide biosynthesis" EXACT [] synonym: "purine nucleotide formation" EXACT [] synonym: "purine nucleotide synthesis" EXACT [] xref: MetaCyc:DENOVOPURINE2-PWY is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0006165 name: nucleoside diphosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai] subset: gosubset_prok is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0046939 ! nucleotide phosphorylation [Term] id: GO:0006166 name: purine ribonucleoside salvage namespace: biological_process def: "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok xref: MetaCyc:P121-PWY is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0006167 name: AMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "AMP anabolism" EXACT [] synonym: "AMP biosynthesis" EXACT [] synonym: "AMP formation" EXACT [] synonym: "AMP synthesis" EXACT [] is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046033 ! AMP metabolic process [Term] id: GO:0006168 name: adenine salvage namespace: biological_process def: "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "adenine salvage pathway" EXACT [] synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine base salvage is_a: GO:0046084 ! adenine biosynthetic process [Term] id: GO:0006169 name: adenosine salvage namespace: biological_process def: "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046086 ! adenosine biosynthetic process [Term] id: GO:0006170 name: dAMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dAMP anabolism" EXACT [] synonym: "dAMP biosynthesis" EXACT [] synonym: "dAMP formation" EXACT [] synonym: "dAMP synthesis" EXACT [] is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046053 ! dAMP metabolic process [Term] id: GO:0006171 name: cAMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "3',5' cAMP biosynthesis" EXACT [] synonym: "3',5' cAMP biosynthetic process" EXACT [] synonym: "3',5'-cAMP biosynthesis" EXACT [] synonym: "3',5'-cAMP biosynthetic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "cAMP anabolism" EXACT [] synonym: "cAMP biosynthesis" EXACT [] synonym: "cAMP formation" EXACT [] synonym: "cAMP synthesis" EXACT [] synonym: "cyclic AMP biosynthesis" EXACT [] synonym: "cyclic AMP biosynthetic process" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009190 ! cyclic nucleotide biosynthetic process is_a: GO:0046058 ! cAMP metabolic process [Term] id: GO:0006172 name: ADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai] subset: gosubset_prok synonym: "ADP anabolism" EXACT [] synonym: "ADP biosynthesis" EXACT [] synonym: "ADP formation" EXACT [] synonym: "ADP synthesis" EXACT [] is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006173 name: dADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dADP anabolism" EXACT [] synonym: "dADP biosynthesis" EXACT [] synonym: "dADP formation" EXACT [] synonym: "dADP synthesis" EXACT [] is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0006174 name: dADP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0006175 name: dATP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dATP anabolism" EXACT [] synonym: "dATP biosynthesis" EXACT [] synonym: "dATP formation" EXACT [] synonym: "dATP synthesis" EXACT [] is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046060 ! dATP metabolic process [Term] id: GO:0006176 name: dATP biosynthetic process from ADP namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dATP anabolism from ADP" EXACT [] synonym: "dATP formation from ADP" EXACT [] synonym: "dATP synthesis from ADP" EXACT [] is_a: GO:0006175 ! dATP biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006177 name: GMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GMP anabolism" EXACT [] synonym: "GMP biosynthesis" EXACT [] synonym: "GMP formation" EXACT [] synonym: "GMP synthesis" EXACT [] is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046037 ! GMP metabolic process [Term] id: GO:0006178 name: guanine salvage namespace: biological_process def: "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine base salvage is_a: GO:0046099 ! guanine biosynthetic process [Term] id: GO:0006179 name: guanosine salvage namespace: biological_process def: "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046114 ! guanosine biosynthetic process [Term] id: GO:0006180 name: deoxyguanosine salvage namespace: biological_process def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043098 ! purine deoxyribonucleoside salvage [Term] id: GO:0006181 name: dGMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dGMP anabolism" EXACT [] synonym: "dGMP biosynthesis" EXACT [] synonym: "dGMP formation" EXACT [] synonym: "dGMP synthesis" EXACT [] is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046054 ! dGMP metabolic process [Term] id: GO:0006182 name: cGMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cGMP anabolism" EXACT [] synonym: "cGMP biosynthesis" EXACT [] synonym: "cGMP formation" EXACT [] synonym: "cGMP synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009190 ! cyclic nucleotide biosynthetic process is_a: GO:0046068 ! cGMP metabolic process [Term] id: GO:0006183 name: GTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GTP anabolism" EXACT [] synonym: "GTP biosynthesis" EXACT [] synonym: "GTP formation" EXACT [] synonym: "GTP synthesis" EXACT [] is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046039 ! GTP metabolic process [Term] id: GO:0006184 name: GTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GTP breakdown" EXACT [] synonym: "GTP catabolism" EXACT [] synonym: "GTP degradation" EXACT [] synonym: "GTP hydrolysis" NARROW [] is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process is_a: GO:0046039 ! GTP metabolic process [Term] id: GO:0006185 name: dGDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dGDP anabolism" EXACT [] synonym: "dGDP biosynthesis" EXACT [] synonym: "dGDP formation" EXACT [] synonym: "dGDP synthesis" EXACT [] is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0006186 name: dGDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0006187 name: dGTP biosynthetic process from dGDP namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dGTP anabolism from dGDP" EXACT [] synonym: "dGTP formation from dGDP" EXACT [] synonym: "dGTP synthesis from dGDP" EXACT [] is_a: GO:0046066 ! dGDP metabolic process is_a: GO:0046071 ! dGTP biosynthetic process [Term] id: GO:0006188 name: IMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "IMP anabolism" EXACT [] synonym: "IMP biosynthesis" EXACT [] synonym: "IMP formation" EXACT [] synonym: "IMP synthesis" EXACT [] is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006189 name: 'de novo' IMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094] subset: gosubset_prok synonym: "'de novo' IMP anabolism" EXACT [] synonym: "'de novo' IMP biosynthesis" EXACT [] synonym: "'de novo' IMP formation" EXACT [] synonym: "'de novo' IMP synthesis" EXACT [] synonym: "'de novo' purine biosynthesis" BROAD [] synonym: "'de novo' purine biosynthetic process" BROAD [] is_a: GO:0006188 ! IMP biosynthetic process [Term] id: GO:0006190 name: inosine salvage namespace: biological_process def: "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "adenine, hypoxanthine and their nucleoside salvage" RELATED [] synonym: "guanine, xanthine and their nucleoside salvage" RELATED [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046103 ! inosine biosynthetic process [Term] id: GO:0006191 name: deoxyinosine salvage namespace: biological_process def: "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043098 ! purine deoxyribonucleoside salvage is_a: GO:0046095 ! deoxyinosine biosynthetic process [Term] id: GO:0006192 name: IDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP." [GOC:ai] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046707 ! IDP metabolic process [Term] id: GO:0006193 name: ITP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ITP breakdown" EXACT [] synonym: "ITP catabolism" EXACT [] synonym: "ITP degradation" EXACT [] synonym: "ITP hydrolysis" EXACT [] is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process is_a: GO:0046041 ! ITP metabolic process [Term] id: GO:0006194 name: dIDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process [Term] id: GO:0006195 name: purine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleotide breakdown" EXACT [] synonym: "purine nucleotide catabolism" EXACT [] synonym: "purine nucleotide degradation" EXACT [] xref: Reactome:1252958 "Purine catabolism" xref: Reactome:1279888 "Purine catabolism" xref: Reactome:1298838 "Purine catabolism" xref: Reactome:1326461 "Purine catabolism" xref: Reactome:1352630 "Purine catabolism" xref: Reactome:1372856 "Purine catabolism" xref: Reactome:1392815 "Purine catabolism" xref: Reactome:1417288 "Purine catabolism" xref: Reactome:1450438 "Purine catabolism" xref: Reactome:1470963 "Purine catabolism" xref: Reactome:1482999 "Purine catabolism" xref: Reactome:1496773 "Purine catabolism" xref: Reactome:1514163 "Purine catabolism" xref: Reactome:1520987 "Purine catabolism" xref: Reactome:1526741 "Purine catabolism" xref: Reactome:1532465 "Purine catabolism" xref: Reactome:1538005 "Purine catabolism" xref: Reactome:1539259 "Purine catabolism" xref: Reactome:1540312 "Purine catabolism" xref: Reactome:74259 "Purine catabolism" is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0006196 name: AMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "AMP breakdown" EXACT [] synonym: "AMP catabolism" EXACT [] synonym: "AMP degradation" EXACT [] is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0046033 ! AMP metabolic process [Term] id: GO:0006197 name: adenylate deaminase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0003876 [Term] id: GO:0006198 name: cAMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "3',5' cAMP catabolic process" EXACT [] synonym: "3',5' cAMP catabolism" EXACT [] synonym: "3',5'-cAMP catabolic process" EXACT [] synonym: "3',5'-cAMP catabolism" EXACT [] synonym: "adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "cAMP breakdown" EXACT [] synonym: "cAMP catabolism" EXACT [] synonym: "cAMP degradation" EXACT [] synonym: "cyclic AMP catabolic process" EXACT [] synonym: "cyclic AMP catabolism" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009214 ! cyclic nucleotide catabolic process is_a: GO:0046058 ! cAMP metabolic process [Term] id: GO:0006199 name: ADP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051061 [Term] id: GO:0006200 name: ATP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] subset: gosubset_prok synonym: "ATP breakdown" EXACT [] synonym: "ATP catabolism" EXACT [] synonym: "ATP degradation" EXACT [] synonym: "ATP hydrolysis" NARROW [] xref: Wikipedia:ATP_hydrolysis is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006201 name: GMP catabolic process to IMP namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GMP breakdown to IMP" EXACT [] synonym: "GMP degradation to IMP" EXACT [] is_a: GO:0046038 ! GMP catabolic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006202 name: GMP catabolic process to guanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GMP breakdown to guanine" EXACT [] synonym: "GMP degradation to guanine" EXACT [] is_a: GO:0046038 ! GMP catabolic process is_a: GO:0046098 ! guanine metabolic process [Term] id: GO:0006203 name: dGTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dGTP breakdown" EXACT [] synonym: "dGTP catabolism" EXACT [] synonym: "dGTP degradation" EXACT [] is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046070 ! dGTP metabolic process [Term] id: GO:0006204 name: IMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "IMP breakdown" EXACT [] synonym: "IMP catabolism" EXACT [] synonym: "IMP degradation" EXACT [] is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006205 name: pyrimidine metabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more appropriate terms were created. is_obsolete: true consider: GO:0006206 consider: GO:0006213 consider: GO:0006220 [Term] id: GO:0006206 name: pyrimidine base metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] subset: gosubset_prok synonym: "pyrimidine base metabolism" EXACT [] synonym: "pyrimidine metabolic process" RELATED [] synonym: "pyrimidine metabolism" RELATED [] synonym: "pyrimidine nucleobase metabolic process" EXACT [CHEBI:26432] xref: Reactome:1252990 "Pyrimidine metabolism" xref: Reactome:1279921 "Pyrimidine metabolism" xref: Reactome:1298816 "Pyrimidine metabolism" xref: Reactome:1326494 "Pyrimidine metabolism" xref: Reactome:1352601 "Pyrimidine metabolism" xref: Reactome:1372833 "Pyrimidine metabolism" xref: Reactome:1392845 "Pyrimidine metabolism" xref: Reactome:1417321 "Pyrimidine metabolism" xref: Reactome:1450407 "Pyrimidine metabolism" xref: Reactome:1470938 "Pyrimidine metabolism" xref: Reactome:1482978 "Pyrimidine metabolism" xref: Reactome:1496750 "Pyrimidine metabolism" xref: Reactome:1514140 "Pyrimidine metabolism" xref: Reactome:1520966 "Pyrimidine metabolism" xref: Reactome:1526718 "Pyrimidine metabolism" xref: Reactome:1532442 "Pyrimidine metabolism" xref: Reactome:1535994 "Pyrimidine metabolism" xref: Reactome:1537994 "Pyrimidine metabolism" xref: Reactome:1539247 "Pyrimidine metabolism" xref: Reactome:1540297 "Pyrimidine metabolism" xref: Reactome:73848 "Pyrimidine metabolism" is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0006207 name: 'de novo' pyrimidine base biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] subset: gosubset_prok synonym: "'de novo' pyrimidine base anabolism" EXACT [] synonym: "'de novo' pyrimidine base biosynthesis" EXACT [] synonym: "'de novo' pyrimidine base formation" EXACT [] synonym: "'de novo' pyrimidine base synthesis" EXACT [] synonym: "'de novo' pyrimidine nucleobase biosynthetic process" EXACT [CHEBI:26432] is_a: GO:0019856 ! pyrimidine base biosynthetic process [Term] id: GO:0006208 name: pyrimidine base catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] subset: gosubset_prok synonym: "pyrimidine base breakdown" EXACT [] synonym: "pyrimidine base catabolism" EXACT [] synonym: "pyrimidine base degradation" EXACT [] synonym: "pyrimidine nucleobase catabolic process" EXACT [CHEBI:26432] is_a: GO:0006206 ! pyrimidine base metabolic process is_a: GO:0046113 ! nucleobase catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0006209 name: cytosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] subset: gosubset_prok synonym: "cytosine breakdown" EXACT [] synonym: "cytosine catabolism" EXACT [] synonym: "cytosine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine base catabolic process is_a: GO:0019858 ! cytosine metabolic process [Term] id: GO:0006210 name: thymine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] subset: gosubset_prok synonym: "thymine breakdown" EXACT [] synonym: "thymine catabolism" EXACT [] synonym: "thymine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine base catabolic process is_a: GO:0019859 ! thymine metabolic process [Term] id: GO:0006211 name: 5-methylcytosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "5-methylcytosine breakdown" EXACT [] synonym: "5-methylcytosine catabolism" EXACT [] synonym: "5-methylcytosine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine base catabolic process is_a: GO:0019857 ! 5-methylcytosine metabolic process [Term] id: GO:0006212 name: uracil catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] subset: gosubset_prok synonym: "uracil breakdown" EXACT [] synonym: "uracil catabolism" EXACT [] synonym: "uracil degradation" EXACT [] is_a: GO:0006208 ! pyrimidine base catabolic process is_a: GO:0019860 ! uracil metabolic process [Term] id: GO:0006213 name: pyrimidine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] synonym: "pyrimidine nucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0006214 name: thymidine catabolic process namespace: biological_process alt_id: GO:0006215 def: "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyribosylthymine catabolic process" EXACT [] synonym: "deoxyribosylthymine catabolism" EXACT [] synonym: "thymidine breakdown" EXACT [] synonym: "thymidine catabolism" EXACT [] synonym: "thymidine degradation" EXACT [] is_a: GO:0046104 ! thymidine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006216 name: cytidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:ai] subset: gosubset_prok synonym: "cytidine breakdown" EXACT [] synonym: "cytidine catabolism" EXACT [] synonym: "cytidine degradation" EXACT [] is_a: GO:0046087 ! cytidine metabolic process is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process [Term] id: GO:0006217 name: deoxycytidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxycytidine breakdown" EXACT [] synonym: "deoxycytidine catabolism" EXACT [] synonym: "deoxycytidine degradation" EXACT [] is_a: GO:0046092 ! deoxycytidine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006218 name: uridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "uridine breakdown" EXACT [] synonym: "uridine catabolism" EXACT [] synonym: "uridine degradation" EXACT [] is_a: GO:0046108 ! uridine metabolic process is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process [Term] id: GO:0006219 name: deoxyuridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyuridine breakdown" EXACT [] synonym: "deoxyuridine catabolism" EXACT [] synonym: "deoxyuridine degradation" EXACT [] is_a: GO:0046096 ! deoxyuridine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006220 name: pyrimidine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] synonym: "pyrimidine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0006221 name: pyrimidine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleotide anabolism" EXACT [] synonym: "pyrimidine nucleotide biosynthesis" EXACT [] synonym: "pyrimidine nucleotide formation" EXACT [] synonym: "pyrimidine nucleotide synthesis" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0006222 name: UMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "UMP anabolism" EXACT [] synonym: "UMP biosynthesis" EXACT [] synonym: "UMP formation" EXACT [] synonym: "UMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0046049 ! UMP metabolic process [Term] id: GO:0006223 name: uracil salvage namespace: biological_process def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0019860 ! uracil metabolic process is_a: GO:0043100 ! pyrimidine base salvage [Term] id: GO:0006224 name: uridine kinase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0004849 [Term] id: GO:0006225 name: UDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "UDP anabolism" EXACT [] synonym: "UDP biosynthesis" EXACT [] synonym: "UDP formation" EXACT [] synonym: "UDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0046048 ! UDP metabolic process [Term] id: GO:0006226 name: dUMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dUMP anabolism" EXACT [] synonym: "dUMP biosynthesis" EXACT [] synonym: "dUMP formation" EXACT [] synonym: "dUMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046078 ! dUMP metabolic process [Term] id: GO:0006227 name: dUDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dUDP anabolism" EXACT [] synonym: "dUDP biosynthesis" EXACT [] synonym: "dUDP formation" EXACT [] synonym: "dUDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046077 ! dUDP metabolic process [Term] id: GO:0006228 name: UTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "UTP anabolism" EXACT [] synonym: "UTP biosynthesis" EXACT [] synonym: "UTP formation" EXACT [] synonym: "UTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0046051 ! UTP metabolic process [Term] id: GO:0006229 name: dUTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dUTP anabolism" EXACT [] synonym: "dUTP biosynthesis" EXACT [] synonym: "dUTP formation" EXACT [] synonym: "dUTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046080 ! dUTP metabolic process [Term] id: GO:0006230 name: TMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TMP anabolism" EXACT [] synonym: "TMP biosynthesis" EXACT [] synonym: "TMP formation" EXACT [] synonym: "TMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0046044 ! TMP metabolic process [Term] id: GO:0006231 name: dTMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dTMP anabolism" EXACT [] synonym: "dTMP biosynthesis" EXACT [] synonym: "dTMP formation" EXACT [] synonym: "dTMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046073 ! dTMP metabolic process [Term] id: GO:0006232 name: TDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TDP anabolism" EXACT [] synonym: "TDP biosynthesis" EXACT [] synonym: "TDP formation" EXACT [] synonym: "TDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0046043 ! TDP metabolic process [Term] id: GO:0006233 name: dTDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dTDP anabolism" EXACT [] synonym: "dTDP biosynthesis" EXACT [] synonym: "dTDP formation" EXACT [] synonym: "dTDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046072 ! dTDP metabolic process [Term] id: GO:0006234 name: TTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TTP anabolism" EXACT [] synonym: "TTP biosynthesis" EXACT [] synonym: "TTP formation" EXACT [] synonym: "TTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0046046 ! TTP metabolic process [Term] id: GO:0006235 name: dTTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dTTP anabolism" EXACT [] synonym: "dTTP biosynthesis" EXACT [] synonym: "dTTP formation" EXACT [] synonym: "dTTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046075 ! dTTP metabolic process [Term] id: GO:0006236 name: cytidine salvage namespace: biological_process def: "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043097 ! pyrimidine nucleoside salvage is_a: GO:0046088 ! cytidine biosynthetic process [Term] id: GO:0006237 name: deoxycytidine salvage namespace: biological_process def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage is_a: GO:0046093 ! deoxycytidine biosynthetic process [Term] id: GO:0006238 name: CMP salvage namespace: biological_process def: "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "cytidine monophosphate salvage" EXACT [] is_a: GO:0009224 ! CMP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage [Term] id: GO:0006239 name: dCMP salvage namespace: biological_process def: "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "deoxycytidine monophosphate salvage" EXACT [] is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage is_a: GO:0046064 ! dCMP biosynthetic process [Term] id: GO:0006240 name: dCDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCDP anabolism" EXACT [] synonym: "dCDP biosynthesis" EXACT [] synonym: "dCDP formation" EXACT [] synonym: "dCDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046062 ! dCDP metabolic process [Term] id: GO:0006241 name: CTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "CTP anabolism" EXACT [] synonym: "CTP biosynthesis" EXACT [] synonym: "CTP formation" EXACT [] synonym: "CTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0046036 ! CTP metabolic process [Term] id: GO:0006242 name: dCTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCTP anabolism" EXACT [] synonym: "dCTP biosynthesis" EXACT [] synonym: "dCTP formation" EXACT [] synonym: "dCTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046065 ! dCTP metabolic process [Term] id: GO:0006244 name: pyrimidine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleotide breakdown" EXACT [] synonym: "pyrimidine nucleotide catabolism" EXACT [] synonym: "pyrimidine nucleotide degradation" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0006245 name: TDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TDP breakdown" EXACT [] synonym: "TDP catabolism" EXACT [] synonym: "TDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0046043 ! TDP metabolic process [Term] id: GO:0006246 name: dTDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dTDP breakdown" EXACT [] synonym: "dTDP catabolism" EXACT [] synonym: "dTDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046072 ! dTDP metabolic process [Term] id: GO:0006247 name: TTP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051064 [Term] id: GO:0006248 name: CMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "CMP breakdown" EXACT [] synonym: "CMP catabolism" EXACT [] synonym: "CMP degradation" EXACT [] is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process is_a: GO:0046035 ! CMP metabolic process [Term] id: GO:0006249 name: dCMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCMP breakdown" EXACT [] synonym: "dCMP catabolism" EXACT [] synonym: "dCMP degradation" EXACT [] is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process is_a: GO:0046063 ! dCMP metabolic process [Term] id: GO:0006250 name: CDP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051063 [Term] id: GO:0006251 name: dCDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCDP breakdown" EXACT [] synonym: "dCDP catabolism" EXACT [] synonym: "dCDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046062 ! dCDP metabolic process [Term] id: GO:0006252 name: CTP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051065 [Term] id: GO:0006253 name: dCTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCTP breakdown" EXACT [] synonym: "dCTP catabolism" EXACT [] synonym: "dCTP degradation" EXACT [] is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046065 ! dCTP metabolic process [Term] id: GO:0006254 name: CTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "CTP breakdown" EXACT [] synonym: "CTP catabolism" EXACT [] synonym: "CTP degradation" EXACT [] synonym: "CTP hydrolysis" EXACT [] is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process is_a: GO:0046036 ! CTP metabolic process [Term] id: GO:0006255 name: UDP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051062 [Term] id: GO:0006256 name: UDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "UDP breakdown" EXACT [] synonym: "UDP catabolism" EXACT [] synonym: "UDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0046048 ! UDP metabolic process [Term] id: GO:0006257 name: dUDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dUDP breakdown" EXACT [] synonym: "dUDP catabolism" EXACT [] synonym: "dUDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046077 ! dUDP metabolic process [Term] id: GO:0006258 name: UDP-glucose catabolic process namespace: biological_process alt_id: GO:0019691 def: "The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-glucose breakdown" EXACT [] synonym: "UDP-glucose catabolism" EXACT [] synonym: "UDP-glucose conversion" RELATED [] synonym: "UDP-glucose degradation" EXACT [] is_a: GO:0006011 ! UDP-glucose metabolic process is_a: GO:0009227 ! nucleotide-sugar catabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0006260 name: DNA replication namespace: biological_process alt_id: GO:0055133 def: "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] comment: See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. subset: goslim_pir subset: goslim_pombe subset: gosubset_prok xref: Reactome:1235837 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:1235846 "Recruitment and activation of Chk1" xref: Reactome:1235848 "Stalling of DNA replication fork and RPA binding" xref: Reactome:1235850 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:1235870 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1235886 "Activation of claspin" xref: Reactome:1235887 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:1252909 "Activation of ATR in response to replication stress" xref: Reactome:1263117 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:1263126 "Recruitment and activation of Chk1" xref: Reactome:1263128 "Stalling of DNA replication fork and RPA binding" xref: Reactome:1263130 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:1263154 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1263163 "Activation of claspin" xref: Reactome:1263164 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:1279843 "Activation of ATR in response to replication stress" xref: Reactome:1287756 "Recruitment and activation of Chk1" xref: Reactome:1298862 "Activation of ATR in response to replication stress" xref: Reactome:1309475 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:1309484 "Recruitment and activation of Chk1" xref: Reactome:1309486 "Stalling of DNA replication fork and RPA binding" xref: Reactome:1309488 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:1309505 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1309514 "Activation of claspin" xref: Reactome:1309515 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:1326412 "Activation of ATR in response to replication stress" xref: Reactome:1336412 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:1336424 "Recruitment and activation of Chk1" xref: Reactome:1336426 "Stalling of DNA replication fork and RPA binding" xref: Reactome:1336428 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:1336448 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1336464 "Activation of claspin" xref: Reactome:1336465 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:1352528 "Activation of ATR in response to replication stress" xref: Reactome:1360397 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:1360406 "Recruitment and activation of Chk1" xref: Reactome:1360408 "Stalling of DNA replication fork and RPA binding" xref: Reactome:1360410 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:1360419 "Activation of claspin" xref: Reactome:1360420 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:1372756 "Activation of ATR in response to replication stress" xref: Reactome:1381179 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:1381192 "Recruitment and activation of Chk1" xref: Reactome:1381194 "Stalling of DNA replication fork and RPA binding" xref: Reactome:1381196 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:1381209 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1381226 "Activation of claspin" xref: Reactome:1381227 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:1392766 "Activation of ATR in response to replication stress" xref: Reactome:1402472 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:1402481 "Recruitment and activation of Chk1" xref: Reactome:1402483 "Stalling of DNA replication fork and RPA binding" xref: Reactome:1402485 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:1402506 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1402515 "Activation of claspin" xref: Reactome:1402516 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:1417243 "Activation of ATR in response to replication stress" xref: Reactome:1430527 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:1430539 "Recruitment and activation of Chk1" xref: Reactome:1430541 "Stalling of DNA replication fork and RPA binding" xref: Reactome:1430543 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:1430566 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1430575 "Activation of claspin" xref: Reactome:1430576 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:1450331 "Activation of ATR in response to replication stress" xref: Reactome:1459113 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1459123 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:1470872 "Activation of ATR in response to replication stress" xref: Reactome:1476624 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1483226 "Activation of ATR in response to replication stress" xref: Reactome:1518138 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1521172 "Activation of ATR in response to replication stress" xref: Reactome:1530550 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:1532653 "Activation of ATR in response to replication stress" xref: Reactome:176101 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:176116 "Recruitment and activation of Chk1" xref: Reactome:176175 "Stalling of DNA replication fork and RPA binding" xref: Reactome:176187 "Activation of ATR in response to replication stress" xref: Reactome:176250 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:176298 "Activation of claspin" xref: Reactome:176318 "Loading of claspin onto DNA during replication origin firing" xref: Wikipedia:DNA_replication is_a: GO:0006259 ! DNA metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:0006261 name: DNA-dependent DNA replication namespace: biological_process alt_id: GO:0006262 alt_id: GO:0006263 def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006260 ! DNA replication [Term] id: GO:0006264 name: mitochondrial DNA replication namespace: biological_process def: "The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai] synonym: "mitochondrial DNA synthesis" RELATED [] synonym: "mtDNA replication" EXACT [] synonym: "mtDNA synthesis" RELATED [] synonym: "replication of mitochondrial DNA" EXACT [] is_a: GO:0006261 ! DNA-dependent DNA replication is_a: GO:0032042 ! mitochondrial DNA metabolic process [Term] id: GO:0006265 name: DNA topological change namespace: biological_process def: "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo. subset: gosubset_prok synonym: "DNA underwinding" NARROW [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0006266 name: DNA ligation namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194] subset: goslim_pir subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006267 name: pre-replicative complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at eukaryotic DNA replication origins during late M phase; its presence is required for replication initiation." [GOC:mah] synonym: "pre-replicative complex formation" EXACT [] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006268 name: DNA unwinding involved in replication namespace: biological_process def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194] comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. subset: gosubset_prok synonym: "DNA unwinding during replication" RELATED [GOC:dph, GOC:tb] synonym: "DNA unwinding factor" RELATED [] is_a: GO:0032508 ! DNA duplex unwinding relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006269 name: DNA replication, synthesis of RNA primer namespace: biological_process def: "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402] subset: gosubset_prok synonym: "replication priming" RELATED [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006270 name: DNA-dependent DNA replication initiation namespace: biological_process alt_id: GO:0042024 def: "The process in which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok synonym: "DNA endoreduplication initiation" NARROW [] synonym: "DNA re-replication initiation" NARROW [] xref: Reactome:1252882 "DNA replication initiation" xref: Reactome:1279816 "DNA replication initiation" xref: Reactome:1298740 "DNA replication initiation" xref: Reactome:1326385 "DNA replication initiation" xref: Reactome:1352501 "DNA replication initiation" xref: Reactome:1392742 "DNA replication initiation" xref: Reactome:1417216 "DNA replication initiation" xref: Reactome:1450304 "DNA replication initiation" xref: Reactome:1470851 "DNA replication initiation" xref: Reactome:1482885 "DNA replication initiation" xref: Reactome:1496682 "DNA replication initiation" xref: Reactome:1514073 "DNA replication initiation" xref: Reactome:1520898 "DNA replication initiation" xref: Reactome:1526642 "DNA replication initiation" xref: Reactome:1532369 "DNA replication initiation" xref: Reactome:1535936 "DNA replication initiation" xref: Reactome:68952 "DNA replication initiation" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006271 name: DNA strand elongation involved in DNA replication namespace: biological_process def: "The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok synonym: "DNA replication elongation" EXACT [] synonym: "DNA strand elongation during DNA replication" RELATED [GOC:dph, GOC:tb] xref: Reactome:1252894 "DNA strand elongation" xref: Reactome:1279828 "DNA strand elongation" xref: Reactome:1298744 "DNA strand elongation" xref: Reactome:1326397 "DNA strand elongation" xref: Reactome:1352513 "DNA strand elongation" xref: Reactome:1372747 "DNA strand elongation" xref: Reactome:1392754 "DNA strand elongation" xref: Reactome:1417228 "DNA strand elongation" xref: Reactome:1450316 "DNA strand elongation" xref: Reactome:1470863 "DNA strand elongation" xref: Reactome:1482896 "DNA strand elongation" xref: Reactome:1496694 "DNA strand elongation" xref: Reactome:1514085 "DNA strand elongation" xref: Reactome:1520910 "DNA strand elongation" xref: Reactome:1526654 "DNA strand elongation" xref: Reactome:1532381 "DNA strand elongation" xref: Reactome:1535953 "DNA strand elongation" xref: Reactome:1539215 "DNA strand elongation" xref: Reactome:69190 "DNA strand elongation" is_a: GO:0022616 ! DNA strand elongation relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006272 name: leading strand elongation namespace: biological_process def: "The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok is_a: GO:0006271 ! DNA strand elongation involved in DNA replication [Term] id: GO:0006273 name: lagging strand elongation namespace: biological_process def: "The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok is_a: GO:0006271 ! DNA strand elongation involved in DNA replication [Term] id: GO:0006274 name: DNA replication termination namespace: biological_process def: "The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006275 name: regulation of DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0006260 ! DNA replication [Term] id: GO:0006276 name: plasmid maintenance namespace: biological_process def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0009987 ! cellular process [Term] id: GO:0006277 name: DNA amplification namespace: biological_process def: "The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464] subset: gosubset_prok is_a: GO:0071897 ! DNA biosynthetic process [Term] id: GO:0006278 name: RNA-dependent DNA replication namespace: biological_process def: "A DNA replication process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:162589 "Reverse Transcription of HIV RNA" xref: Reactome:164516 "Minus-strand DNA synthesis" xref: Reactome:164525 "Plus-strand DNA synthesis" is_a: GO:0006260 ! DNA replication [Term] id: GO:0006279 name: premeiotic DNA replication namespace: biological_process def: "The replication of DNA that precedes meiotic cell division." [GOC:ai] synonym: "meiotic DNA replication" RELATED [GOC:mah] synonym: "meiotic DNA synthesis" RELATED [GOC:mah] synonym: "premeiotic DNA synthesis" RELATED [GOC:mah] is_a: GO:0006260 ! DNA replication [Term] id: GO:0006280 name: mutagenesis namespace: biological_process def: "OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent. subset: gosubset_prok is_obsolete: true consider: GO:0006281 consider: GO:0051276 [Term] id: GO:0006281 name: DNA repair namespace: biological_process def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] subset: goslim_pir subset: goslim_pombe subset: gosubset_prok xref: Reactome:1253001 "DNA Damage Reversal" xref: Reactome:1253002 "DNA Repair" xref: Reactome:1279931 "DNA Damage Reversal" xref: Reactome:1279932 "DNA Repair" xref: Reactome:1298827 "DNA Damage Reversal" xref: Reactome:1298828 "DNA Repair" xref: Reactome:1326505 "DNA Damage Reversal" xref: Reactome:1326506 "DNA Repair" xref: Reactome:1352612 "DNA Damage Reversal" xref: Reactome:1352613 "DNA Repair" xref: Reactome:1372843 "DNA Damage Reversal" xref: Reactome:1372844 "DNA Repair" xref: Reactome:1392856 "DNA Damage Reversal" xref: Reactome:1392857 "DNA Repair" xref: Reactome:1417331 "DNA Damage Reversal" xref: Reactome:1417332 "DNA Repair" xref: Reactome:1450420 "DNA Damage Reversal" xref: Reactome:1450421 "DNA Repair" xref: Reactome:1470949 "DNA Damage Reversal" xref: Reactome:1470950 "DNA Repair" xref: Reactome:1482989 "DNA Damage Reversal" xref: Reactome:1482990 "DNA Repair" xref: Reactome:1496770 "DNA Repair" xref: Reactome:1496851 "DNA Damage Reversal" xref: Reactome:1514160 "DNA Repair" xref: Reactome:1514244 "DNA Damage Reversal" xref: Reactome:1520977 "DNA Damage Reversal" xref: Reactome:1520978 "DNA Repair" xref: Reactome:1526728 "DNA Damage Reversal" xref: Reactome:1526729 "DNA Repair" xref: Reactome:1532462 "DNA Repair" xref: Reactome:1536010 "DNA Repair" xref: Reactome:1537999 "DNA Damage Reversal" xref: Reactome:1538000 "DNA Repair" xref: Reactome:1539252 "DNA Damage Reversal" xref: Reactome:1539253 "DNA Repair" xref: Reactome:1540303 "DNA Damage Reversal" xref: Reactome:1540304 "DNA Repair" xref: Reactome:73894 "DNA Repair" xref: Reactome:73942 "DNA Damage Reversal" xref: Wikipedia:DNA_repair is_a: GO:0006259 ! DNA metabolic process is_a: GO:0006974 ! response to DNA damage stimulus [Term] id: GO:0006282 name: regulation of DNA repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0006281 ! DNA repair [Term] id: GO:0006283 name: transcription-coupled nucleotide-excision repair namespace: biological_process def: "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [PMID:10197977, PMID:11900249] subset: gosubset_prok synonym: "TC-NER" EXACT [PMID:10197977] synonym: "TCR" RELATED [GOC:vw, PMID:18794354] synonym: "transcription-coupled NER" EXACT [GOC:mah] synonym: "transcription-coupled repair" EXACT [GOC:vw, PMID:18794354] xref: Reactome:1253167 "Transcription-coupled NER (TC-NER)" xref: Reactome:1280100 "Transcription-coupled NER (TC-NER)" xref: Reactome:1298981 "Transcription-coupled NER (TC-NER)" xref: Reactome:1326672 "Transcription-coupled NER (TC-NER)" xref: Reactome:1352784 "Transcription-coupled NER (TC-NER)" xref: Reactome:1372994 "Transcription-coupled NER (TC-NER)" xref: Reactome:1393011 "Transcription-coupled NER (TC-NER)" xref: Reactome:1417487 "Transcription-coupled NER (TC-NER)" xref: Reactome:1450584 "Transcription-coupled NER (TC-NER)" xref: Reactome:1471090 "Transcription-coupled NER (TC-NER)" xref: Reactome:1483106 "Transcription-coupled NER (TC-NER)" xref: Reactome:1496827 "Transcription-coupled NER (TC-NER)" xref: Reactome:1514221 "Transcription-coupled NER (TC-NER)" xref: Reactome:1521061 "Transcription-coupled NER (TC-NER)" xref: Reactome:1526829 "Transcription-coupled NER (TC-NER)" xref: Reactome:1532555 "Transcription-coupled NER (TC-NER)" xref: Reactome:1536029 "Transcription-coupled NER (TC-NER)" xref: Reactome:1539280 "Transcription-coupled NER (TC-NER)" xref: Reactome:73937 "Transcription-coupled NER (TC-NER)" is_a: GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006284 name: base-excision repair namespace: biological_process def: "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] subset: gosubset_prok synonym: "BER" EXACT [] xref: Reactome:1253009 "Base Excision Repair" xref: Reactome:1279939 "Base Excision Repair" xref: Reactome:1298986 "Base Excision Repair" xref: Reactome:1326513 "Base Excision Repair" xref: Reactome:1352620 "Base Excision Repair" xref: Reactome:1372999 "Base Excision Repair" xref: Reactome:1393015 "Base Excision Repair" xref: Reactome:1417339 "Base Excision Repair" xref: Reactome:1450428 "Base Excision Repair" xref: Reactome:1471096 "Base Excision Repair" xref: Reactome:1483112 "Base Excision Repair" xref: Reactome:1496833 "Base Excision Repair" xref: Reactome:1514227 "Base Excision Repair" xref: Reactome:1520985 "Base Excision Repair" xref: Reactome:1526835 "Base Excision Repair" xref: Reactome:1532561 "Base Excision Repair" xref: Reactome:1536034 "Base Excision Repair" xref: Reactome:1538022 "Base Excision Repair" xref: Reactome:1539284 "Base Excision Repair" xref: Reactome:1540322 "Base Excision Repair" xref: Reactome:73884 "Base Excision Repair" xref: Wikipedia:Base_excision_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006285 name: base-excision repair, AP site formation namespace: biological_process def: "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194] subset: gosubset_prok xref: Reactome:1253172 "Base-Excision Repair, AP Site Formation" xref: Reactome:1280105 "Base-Excision Repair, AP Site Formation" xref: Reactome:1298985 "Base-Excision Repair, AP Site Formation" xref: Reactome:1326677 "Base-Excision Repair, AP Site Formation" xref: Reactome:1352789 "Base-Excision Repair, AP Site Formation" xref: Reactome:1372998 "Base-Excision Repair, AP Site Formation" xref: Reactome:1393014 "Base-Excision Repair, AP Site Formation" xref: Reactome:1417492 "Base-Excision Repair, AP Site Formation" xref: Reactome:1450589 "Base-Excision Repair, AP Site Formation" xref: Reactome:1471095 "Base-Excision Repair, AP Site Formation" xref: Reactome:1483111 "Base-Excision Repair, AP Site Formation" xref: Reactome:1496832 "Base-Excision Repair, AP Site Formation" xref: Reactome:1514226 "Base-Excision Repair, AP Site Formation" xref: Reactome:1521066 "Base-Excision Repair, AP Site Formation" xref: Reactome:1526834 "Base-Excision Repair, AP Site Formation" xref: Reactome:1532560 "Base-Excision Repair, AP Site Formation" xref: Reactome:1536033 "Base-Excision Repair, AP Site Formation" xref: Reactome:1538021 "Base-Excision Repair, AP Site Formation" xref: Reactome:1539283 "Base-Excision Repair, AP Site Formation" xref: Reactome:1540321 "Base-Excision Repair, AP Site Formation" xref: Reactome:73929 "Base-Excision Repair, AP Site Formation" is_a: GO:0006308 ! DNA catabolic process relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006286 name: base-excision repair, base-free sugar-phosphate removal namespace: biological_process def: "Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme." [ISBN:0815316194] subset: gosubset_prok xref: Reactome:110375 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:1231000 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:1258781 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:1284239 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:1304715 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:1332351 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:1377923 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:1398294 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:1424681 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:1517174 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" is_a: GO:0006308 ! DNA catabolic process is_a: GO:0016311 ! dephosphorylation relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006287 name: base-excision repair, gap-filling namespace: biological_process def: "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006288 name: base-excision repair, DNA ligation namespace: biological_process def: "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair." [ISBN:1550091131] subset: gosubset_prok xref: Reactome:110370 "Ligation of DNA at sites of patch replacement" xref: Reactome:1229016 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:1230997 "Ligation of DNA at sites of patch replacement" xref: Reactome:1256757 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:1258778 "Ligation of DNA at sites of patch replacement" xref: Reactome:1284235 "Ligation of DNA at sites of patch replacement" xref: Reactome:1302845 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:1304712 "Ligation of DNA at sites of patch replacement" xref: Reactome:1330204 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:1332348 "Ligation of DNA at sites of patch replacement" xref: Reactome:1396446 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:1398291 "Ligation of DNA at sites of patch replacement" xref: Reactome:1422203 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:1424678 "Ligation of DNA at sites of patch replacement" xref: Reactome:1488469 "Ligation of DNA at sites of patch replacement" xref: Reactome:1503273 "Ligation of DNA at sites of patch replacement" xref: Reactome:1516405 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:73931 "DNA ligation via the single-nucleotide replacement pathway" is_a: GO:0051103 ! DNA ligation involved in DNA repair relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006289 name: nucleotide-excision repair namespace: biological_process alt_id: GO:0045001 def: "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. subset: gosubset_prok synonym: "interstrand crosslink repair" NARROW [] synonym: "intrastrand cross-link repair" RELATED [] synonym: "NER" EXACT [] synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] xref: Reactome:1253012 "Nucleotide Excision Repair" xref: Reactome:1279942 "Nucleotide Excision Repair" xref: Reactome:1298835 "Nucleotide Excision Repair" xref: Reactome:1326516 "Nucleotide Excision Repair" xref: Reactome:1352623 "Nucleotide Excision Repair" xref: Reactome:1372851 "Nucleotide Excision Repair" xref: Reactome:1392864 "Nucleotide Excision Repair" xref: Reactome:1417342 "Nucleotide Excision Repair" xref: Reactome:1450431 "Nucleotide Excision Repair" xref: Reactome:1470959 "Nucleotide Excision Repair" xref: Reactome:1482996 "Nucleotide Excision Repair" xref: Reactome:1496769 "Nucleotide Excision Repair" xref: Reactome:1514159 "Nucleotide Excision Repair" xref: Reactome:1521002 "Nucleotide Excision Repair" xref: Reactome:1526738 "Nucleotide Excision Repair" xref: Reactome:1532461 "Nucleotide Excision Repair" xref: Reactome:1536009 "Nucleotide Excision Repair" xref: Reactome:1539262 "Nucleotide Excision Repair" xref: Reactome:73885 "Nucleotide Excision Repair" is_a: GO:0006281 ! DNA repair [Term] id: GO:0006290 name: pyrimidine dimer repair namespace: biological_process def: "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0006291 name: pyrimidine-dimer repair, DNA damage excision namespace: biological_process def: "OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme." [ISBN:0815316194] comment: This term was made obsolete because this process can be subdivided into multiple processes. is_obsolete: true consider: GO:0006289 [Term] id: GO:0006292 name: pyrimidine-dimer repair, DNA damage recognition namespace: biological_process def: "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers." [ISBN:0815316194] comment: This term was made obsolete because it is a substrate specific DNA repair process. is_obsolete: true consider: GO:0000715 consider: GO:0000716 [Term] id: GO:0006293 name: nucleotide-excision repair, preincision complex stabilization namespace: biological_process def: "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok xref: Reactome:109953 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1230767 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1258566 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1304500 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1332126 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1398092 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1424444 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1456310 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1488230 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1503065 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1523988 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:1529693 "Binding of ERCC1-XPF to preincision complex" is_a: GO:0031334 ! positive regulation of protein complex assembly relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006294 name: nucleotide-excision repair, preincision complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "nucleotide-excision repair, preincision complex formation" EXACT [] xref: Reactome:1302874 "Recruitment of repair factors to form preincision complex" xref: Reactome:1330244 "Recruitment of repair factors to form preincision complex" xref: Reactome:1355373 "Recruitment of repair factors to form preincision complex" xref: Reactome:1376349 "Recruitment of repair factors to form preincision complex" xref: Reactome:1422243 "Recruitment of repair factors to form preincision complex" xref: Reactome:73936 "Recruitment of repair factors to form preincision complex" is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006295 name: nucleotide-excision repair, DNA incision, 3'-to lesion namespace: biological_process def: "The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "nucleotide-excision repair, DNA incision, 3' to lesion" EXACT [] xref: Reactome:1229064 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1256794 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1282653 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1302885 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1330262 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1355382 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1376358 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1396483 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1422257 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1454696 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1474383 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1486898 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1501442 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1523465 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:1529081 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:73938 "3'- incision of DNA by XPG in GG-NER" is_a: GO:0033683 ! nucleotide-excision repair, DNA incision [Term] id: GO:0006296 name: nucleotide-excision repair, DNA incision, 5'-to lesion namespace: biological_process def: "The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "nucleotide-excision repair, DNA incision, 5' to lesion" EXACT [] xref: Reactome:1302887 "5'-incision of DNA by ERCC1-XPF in GG-NER" xref: Reactome:1330264 "5'-incision of DNA by ERCC1-XPF in GG-NER" xref: Reactome:1422259 "5'-incision of DNA by ERCC1-XPF in GG-NER" xref: Reactome:73939 "5'-incision of DNA by ERCC1-XPF in GG-NER" is_a: GO:0033683 ! nucleotide-excision repair, DNA incision [Term] id: GO:0006297 name: nucleotide-excision repair, DNA gap filling namespace: biological_process def: "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes." [ISBN:0815316194] subset: gosubset_prok xref: Reactome:1253038 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1279970 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1298859 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1326543 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1352655 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1372873 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1393009 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1417362 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1450463 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1470981 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1483012 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1496776 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1514166 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1521000 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1526744 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1532468 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1536007 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:1539260 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:74969 "Gap-filling DNA repair synthesis and ligation in GG-NER" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006298 name: mismatch repair namespace: biological_process alt_id: GO:0006300 def: "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11687886] subset: gosubset_prok synonym: "long patch mismatch repair system" NARROW [] synonym: "mismatch repair, MutL-like pathway" RELATED [] synonym: "MMR" EXACT [] synonym: "MutS/MutL/MutH pathway" RELATED [] xref: Wikipedia:DNA_mismatch_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006299 name: short patch mismatch repair system namespace: biological_process def: "OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site." [PMID:10660619, PMID:10878254] comment: This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair. is_obsolete: true consider: GO:0006284 consider: GO:0006289 [Term] id: GO:0006301 name: postreplication repair namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] subset: gosubset_prok synonym: "postreplication DNA repair" EXACT [GOC:curators] xref: Wikipedia:Postreplication_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006302 name: double-strand break repair namespace: biological_process def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] subset: gosubset_prok xref: Reactome:1253052 "Double-Strand Break Repair" xref: Reactome:1279988 "Double-Strand Break Repair" xref: Reactome:1298881 "Double-Strand Break Repair" xref: Reactome:1326558 "Double-Strand Break Repair" xref: Reactome:1352670 "Double-Strand Break Repair" xref: Reactome:1372886 "Double-Strand Break Repair" xref: Reactome:1392906 "Double-Strand Break Repair" xref: Reactome:1417376 "Double-Strand Break Repair" xref: Reactome:1450477 "Double-Strand Break Repair" xref: Reactome:1470991 "Double-Strand Break Repair" xref: Reactome:1483019 "Double-Strand Break Repair" xref: Reactome:1496786 "Double-Strand Break Repair" xref: Reactome:1514176 "Double-Strand Break Repair" xref: Reactome:1521016 "Double-Strand Break Repair" xref: Reactome:1526750 "Double-Strand Break Repair" xref: Reactome:1532481 "Double-Strand Break Repair" xref: Reactome:1536018 "Double-Strand Break Repair" xref: Reactome:1539267 "Double-Strand Break Repair" xref: Reactome:73890 "Double-Strand Break Repair" is_a: GO:0006281 ! DNA repair [Term] id: GO:0006303 name: double-strand break repair via nonhomologous end joining namespace: biological_process def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends." [PMID:10827453] subset: gosubset_prok synonym: "NHEJ" EXACT [] xref: Reactome:1253073 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1280008 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1298898 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1326578 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1352690 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1372907 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1392922 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1417405 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1450497 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1471010 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1483036 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1496803 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1514193 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1521030 "Nonhomologous End-joining (NHEJ)" xref: Reactome:1532497 "Nonhomologous End-joining (NHEJ)" xref: Reactome:73889 "Nonhomologous End-joining (NHEJ)" is_a: GO:0000726 ! non-recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0006304 name: DNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma] subset: goslim_pir subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0006305 name: DNA alkylation namespace: biological_process def: "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970] subset: gosubset_prok is_a: GO:0006304 ! DNA modification [Term] id: GO:0006306 name: DNA methylation namespace: biological_process def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Wikipedia:DNA_methylation is_a: GO:0006305 ! DNA alkylation is_a: GO:0040029 ! regulation of gene expression, epigenetic is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0006307 name: DNA dealkylation involved in DNA repair namespace: biological_process def: "The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT)." [PMID:10946226] subset: gosubset_prok xref: Reactome:112122 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:112126 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1228989 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1253205 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1253206 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1253207 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1256725 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1280139 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1280140 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1280141 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1282608 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1299019 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1299020 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1302818 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1326711 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1326712 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1326713 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1330177 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1352823 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1352824 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1352825 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1355331 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1373032 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1373033 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1373034 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1376307 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1393049 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1393050 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1393051 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1396415 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1417525 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1417526 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1417527 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1422181 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1450621 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1450622 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1450623 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1454620 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1474340 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1496849 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1496850 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1514242 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1514243 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1516368 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1523413 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1536742 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1538457 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:1539304 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:1539305 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:1539306 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:1539768 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:73892 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:73943 "Reversal of Alkylation Damage By DNA Dioxygenases" is_a: GO:0035510 ! DNA dealkylation relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0006308 name: DNA catabolic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "DNA breakdown" EXACT [] synonym: "DNA catabolism" EXACT [] synonym: "DNA degradation" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0006309 name: DNA fragmentation involved in apoptotic nuclear change namespace: biological_process alt_id: GO:0008178 def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:tb, ISBN:0721639976] synonym: "DNA catabolic process during apoptosis" EXACT [] synonym: "DNA catabolism during apoptosis" EXACT [] synonym: "DNA fragmentation" BROAD [] synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT [] xref: Reactome:1253581 "Apoptosis induced DNA fragmentation" xref: Reactome:1280516 "Apoptosis induced DNA fragmentation" xref: Reactome:1299346 "Apoptosis induced DNA fragmentation" xref: Reactome:1327098 "Apoptosis induced DNA fragmentation" xref: Reactome:1353192 "Apoptosis induced DNA fragmentation" xref: Reactome:1373370 "Apoptosis induced DNA fragmentation" xref: Reactome:1393393 "Apoptosis induced DNA fragmentation" xref: Reactome:140342 "Apoptosis induced DNA fragmentation" xref: Reactome:1417889 "Apoptosis induced DNA fragmentation" xref: Reactome:1450979 "Apoptosis induced DNA fragmentation" xref: Reactome:1471360 "Apoptosis induced DNA fragmentation" is_a: GO:0000737 ! DNA catabolic process, endonucleolytic is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0030262 ! apoptotic nuclear change [Term] id: GO:0006310 name: DNA recombination namespace: biological_process def: "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pombe subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006311 name: meiotic gene conversion namespace: biological_process def: "The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194] synonym: "gene conversion without reciprocal crossover" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0035822 ! gene conversion relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0006312 name: mitotic recombination namespace: biological_process def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh] xref: Wikipedia:Mitotic_crossover is_a: GO:0006310 ! DNA recombination [Term] id: GO:0006313 name: transposition, DNA-mediated namespace: biological_process alt_id: GO:0006317 alt_id: GO:0006318 def: "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:1555812090] subset: gosubset_prok synonym: "Class II transposition" EXACT [] synonym: "cut-and-paste transposition" EXACT [] synonym: "DNA transposition" EXACT [GOC:dph] synonym: "P-element excision" NARROW [] synonym: "P-element transposition" NARROW [] synonym: "Tc1/mariner transposition" NARROW [] synonym: "Tc3 transposition" NARROW [] is_a: GO:0006310 ! DNA recombination is_a: GO:0032196 ! transposition [Term] id: GO:0006314 name: intron homing namespace: biological_process def: "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron." [PMID:10487208] subset: gosubset_prok is_a: GO:0006310 ! DNA recombination [Term] id: GO:0006315 name: homing of group II introns namespace: biological_process def: "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure." [GOC:mcc, ISBN:0716743663, PMID:10487208] subset: gosubset_prok is_a: GO:0006314 ! intron homing [Term] id: GO:0006316 name: movement of group I intron namespace: biological_process def: "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction." [GOC:mcc, ISBN:0716743663, PMID:10487208] subset: gosubset_prok is_a: GO:0006314 ! intron homing [Term] id: GO:0006323 name: DNA packaging namespace: biological_process def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "DNA organisation" EXACT [GOC:curators] synonym: "DNA organization" EXACT [GOC:curators] is_a: GO:0071103 ! DNA conformation change is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0006324 name: S phase-specific histone modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026] synonym: "S-phase-specific histone modification" EXACT [] is_a: GO:0016570 ! histone modification relationship: part_of GO:0051320 ! S phase [Term] id: GO:0006325 name: chromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0006326 name: bent DNA binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0003681 [Term] id: GO:0006327 name: random coil binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0003695 [Term] id: GO:0006328 name: AT binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0003680 [Term] id: GO:0006329 name: satellite DNA binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0003696 [Term] id: GO:0006330 name: single-stranded DNA binding namespace: biological_process alt_id: GO:0006331 alt_id: GO:0006332 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0003697 [Term] id: GO:0006333 name: chromatin assembly or disassembly namespace: biological_process def: "The formation or destruction of chromatin structures." [GOC:mah] synonym: "chromatin assembly/disassembly" EXACT [] is_a: GO:0006325 ! chromatin organization [Term] id: GO:0006334 name: nucleosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] synonym: "histone chaperone" RELATED [GOC:vw] synonym: "nucleosome modeling" EXACT [] xref: Reactome:774815 "Nucleosome assembly" is_a: GO:0034728 ! nucleosome organization is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0031497 ! chromatin assembly [Term] id: GO:0006335 name: DNA replication-dependent nucleosome assembly namespace: biological_process def: "The formation of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah] is_a: GO:0006334 ! nucleosome assembly is_a: GO:0034723 ! DNA replication-dependent nucleosome organization [Term] id: GO:0006336 name: DNA replication-independent nucleosome assembly namespace: biological_process def: "The formation of nucleosomes outside the context of DNA replication." [GOC:mah] synonym: "transcription-coupled nucleosome assembly" EXACT [] is_a: GO:0006334 ! nucleosome assembly is_a: GO:0034724 ! DNA replication-independent nucleosome organization [Term] id: GO:0006337 name: nucleosome disassembly namespace: biological_process def: "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] is_a: GO:0032986 ! protein-DNA complex disassembly is_a: GO:0034728 ! nucleosome organization relationship: part_of GO:0031498 ! chromatin disassembly [Term] id: GO:0006338 name: chromatin remodeling namespace: biological_process def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] synonym: "chromatin modeling" EXACT [] synonym: "chromatin modelling" EXACT [] synonym: "chromatin remodelling" EXACT [] is_a: GO:0016568 ! chromatin modification [Term] id: GO:0006339 name: positive regulation of transcription of homeotic gene (trithorax group) namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0006340 name: negative regulation of transcription of homeotic gene (Polycomb group) namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0006341 name: chromatin insulator sequence binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0043035 [Term] id: GO:0006342 name: chromatin silencing namespace: biological_process alt_id: GO:0016440 def: "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] comment: Note that this process is the opposite of chromatin-mediated maintenance of transcription. This regulation is exemplified by members of the Polycomb group, which maintain the inactive state of homeotic gene transcription. synonym: "chromatin-mediated maintenance of transcriptional inactivation" EXACT [] synonym: "chromatin-mediated silencing" EXACT [] synonym: "heterochromatic silencing" RELATED [] synonym: "TGS" EXACT [] synonym: "transcriptional gene silencing" EXACT [] is_a: GO:0016458 ! gene silencing is_a: GO:0045814 ! negative regulation of gene expression, epigenetic is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0006343 name: establishment of chromatin silencing namespace: biological_process def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin." [GOC:mah] synonym: "establishment of heterochromatic silencing" RELATED [] is_a: GO:0006338 ! chromatin remodeling relationship: part_of GO:0006342 ! chromatin silencing [Term] id: GO:0006344 name: maintenance of chromatin silencing namespace: biological_process def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin." [GOC:mah] synonym: "maintenance of heterochromatic silencing" RELATED [] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006342 ! chromatin silencing [Term] id: GO:0006345 name: loss of chromatin silencing namespace: biological_process def: "The process leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:go_curators] is_a: GO:0031936 ! negative regulation of chromatin silencing [Term] id: GO:0006346 name: methylation-dependent chromatin silencing namespace: biological_process def: "Repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:mah] synonym: "methylation-dependent heterochromatic silencing" EXACT [] is_a: GO:0006342 ! chromatin silencing is_a: GO:0016569 ! covalent chromatin modification [Term] id: GO:0006348 name: chromatin silencing at telomere namespace: biological_process def: "Repression of transcription of telomeric DNA by altering the structure of chromatin." [PMID:10219245] synonym: "heterochromatic silencing at telomere" EXACT [] synonym: "telomere chromatin silencing" EXACT [GOC:mah] synonym: "telomeric silencing" EXACT [GOC:bf] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0006349 name: regulation of gene expression by genetic imprinting namespace: biological_process def: "Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11498578] synonym: "regulation of gene expression by DNA imprinting" EXACT [GOC:mah] xref: Wikipedia:Genomic_imprinting is_a: GO:0040029 ! regulation of gene expression, epigenetic is_a: GO:0071514 ! genetic imprinting [Term] id: GO:0006351 name: transcription, DNA-dependent namespace: biological_process alt_id: GO:0006350 alt_id: GO:0061018 alt_id: GO:0061022 def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] subset: gosubset_prok synonym: "cellular transcription" BROAD [] synonym: "cellular transcription, DNA-dependent" EXACT [] synonym: "transcription" BROAD [] xref: Reactome:1252979 "Transcription" xref: Reactome:1252997 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1279909 "Transcription" xref: Reactome:1279927 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1298822 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1298823 "Transcription" xref: Reactome:1326482 "Transcription" xref: Reactome:1326501 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1352608 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1352609 "Transcription" xref: Reactome:1372824 "Transcription" xref: Reactome:1372840 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1392834 "Transcription" xref: Reactome:1392852 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1417309 "Transcription" xref: Reactome:1417327 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1450414 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1450415 "Transcription" xref: Reactome:1470926 "Transcription" xref: Reactome:1470945 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1482966 "Transcription" xref: Reactome:1482985 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1496757 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1496758 "Transcription" xref: Reactome:1514147 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1514148 "Transcription" xref: Reactome:1520973 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1520974 "Transcription" xref: Reactome:1526724 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1526725 "Transcription" xref: Reactome:1532448 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:1532449 "Transcription" xref: Reactome:1536047 "Transcription" xref: Reactome:504046 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:74159 "Transcription" xref: Wikipedia:Transcription_(genetics) is_a: GO:0032774 ! RNA biosynthetic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006352 name: transcription initiation, DNA-dependent namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. subset: gosubset_prok synonym: "DNA-dependent RNA polymerase complex assembly at promoter" EXACT [] synonym: "initiation of transcription, DNA-dependent" EXACT [GOC:mah] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006353 name: transcription termination, DNA-dependent namespace: biological_process def: "The cellular process that completes DNA-dependent transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161] subset: gosubset_prok synonym: "termination of transcription, DNA-dependent" EXACT [GOC:mah] synonym: "transcriptional complex disassembly" BROAD [] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006354 name: transcription elongation, DNA-dependent namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161] subset: goslim_pir subset: gosubset_prok synonym: "RNA elongation" BROAD [] synonym: "transcriptional elongation, DNA-dependent" EXACT [] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006355 name: regulation of transcription, DNA-dependent namespace: biological_process alt_id: GO:0032583 alt_id: GO:0045449 alt_id: GO:0061019 def: "Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH] subset: gosubset_prok synonym: "regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "regulation of gene-specific transcription" RELATED [] synonym: "transcriptional control" BROAD [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051252 ! regulation of RNA metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006356 name: regulation of transcription from RNA polymerase I promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators] synonym: "regulation of transcription from Pol I promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent relationship: regulates GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0006357 name: regulation of transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0006358 alt_id: GO:0010551 def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "global transcription regulation from Pol II promoter" RELATED [] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "regulation of global transcription from Pol II promoter" RELATED [] synonym: "regulation of transcription from Pol II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0006359 name: regulation of transcription from RNA polymerase III promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [GOC:go_curators] synonym: "regulation of transcription from Pol III promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent relationship: regulates GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0006360 name: transcription from RNA polymerase I promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl] synonym: "transcription from Pol I promoter" EXACT [] xref: Reactome:1252996 "RNA Polymerase I Transcription" xref: Reactome:1279926 "RNA Polymerase I Transcription" xref: Reactome:1298821 "RNA Polymerase I Transcription" xref: Reactome:1326500 "RNA Polymerase I Transcription" xref: Reactome:1352607 "RNA Polymerase I Transcription" xref: Reactome:1372839 "RNA Polymerase I Transcription" xref: Reactome:1392851 "RNA Polymerase I Transcription" xref: Reactome:1417326 "RNA Polymerase I Transcription" xref: Reactome:1450413 "RNA Polymerase I Transcription" xref: Reactome:1470944 "RNA Polymerase I Transcription" xref: Reactome:1482984 "RNA Polymerase I Transcription" xref: Reactome:1496756 "RNA Polymerase I Transcription" xref: Reactome:1514146 "RNA Polymerase I Transcription" xref: Reactome:1520972 "RNA Polymerase I Transcription" xref: Reactome:1526723 "RNA Polymerase I Transcription" xref: Reactome:1532447 "RNA Polymerase I Transcription" xref: Reactome:73864 "RNA Polymerase I Transcription" is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006361 name: transcription initiation from RNA polymerase I promoter namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol I promoter" EXACT [] xref: Reactome:1252994 "RNA Polymerase I Promoter Opening" xref: Reactome:1252995 "RNA Polymerase I Promoter Clearance" xref: Reactome:1252998 "RNA Polymerase I Transcription Initiation" xref: Reactome:1252999 "RNA Polymerase I Promoter Escape" xref: Reactome:1279924 "RNA Polymerase I Promoter Opening" xref: Reactome:1279925 "RNA Polymerase I Promoter Clearance" xref: Reactome:1279928 "RNA Polymerase I Transcription Initiation" xref: Reactome:1279929 "RNA Polymerase I Promoter Escape" xref: Reactome:1298819 "RNA Polymerase I Promoter Opening" xref: Reactome:1298820 "RNA Polymerase I Promoter Clearance" xref: Reactome:1298824 "RNA Polymerase I Transcription Initiation" xref: Reactome:1326498 "RNA Polymerase I Promoter Opening" xref: Reactome:1326499 "RNA Polymerase I Promoter Clearance" xref: Reactome:1326502 "RNA Polymerase I Transcription Initiation" xref: Reactome:1326503 "RNA Polymerase I Promoter Escape" xref: Reactome:1352605 "RNA Polymerase I Transcription Initiation" xref: Reactome:1352606 "RNA Polymerase I Promoter Clearance" xref: Reactome:1372837 "RNA Polymerase I Transcription Initiation" xref: Reactome:1372838 "RNA Polymerase I Promoter Clearance" xref: Reactome:1392849 "RNA Polymerase I Promoter Opening" xref: Reactome:1392850 "RNA Polymerase I Promoter Clearance" xref: Reactome:1392853 "RNA Polymerase I Transcription Initiation" xref: Reactome:1392854 "RNA Polymerase I Promoter Escape" xref: Reactome:1417324 "RNA Polymerase I Promoter Opening" xref: Reactome:1417325 "RNA Polymerase I Promoter Clearance" xref: Reactome:1417328 "RNA Polymerase I Transcription Initiation" xref: Reactome:1417329 "RNA Polymerase I Promoter Escape" xref: Reactome:1450411 "RNA Polymerase I Promoter Opening" xref: Reactome:1450412 "RNA Polymerase I Promoter Clearance" xref: Reactome:1450416 "RNA Polymerase I Transcription Initiation" xref: Reactome:1450417 "RNA Polymerase I Promoter Escape" xref: Reactome:1470942 "RNA Polymerase I Transcription Initiation" xref: Reactome:1470943 "RNA Polymerase I Promoter Clearance" xref: Reactome:1470946 "RNA Polymerase I Promoter Escape" xref: Reactome:1482982 "RNA Polymerase I Transcription Initiation" xref: Reactome:1482983 "RNA Polymerase I Promoter Clearance" xref: Reactome:1482986 "RNA Polymerase I Promoter Escape" xref: Reactome:1496754 "RNA Polymerase I Transcription Initiation" xref: Reactome:1496755 "RNA Polymerase I Promoter Clearance" xref: Reactome:1514144 "RNA Polymerase I Transcription Initiation" xref: Reactome:1514145 "RNA Polymerase I Promoter Clearance" xref: Reactome:1520970 "RNA Polymerase I Transcription Initiation" xref: Reactome:1520971 "RNA Polymerase I Promoter Clearance" xref: Reactome:1526721 "RNA Polymerase I Transcription Initiation" xref: Reactome:1526722 "RNA Polymerase I Promoter Clearance" xref: Reactome:1532445 "RNA Polymerase I Transcription Initiation" xref: Reactome:1532446 "RNA Polymerase I Promoter Clearance" xref: Reactome:1532450 "RNA Polymerase I Promoter Escape" xref: Reactome:73728 "RNA Polymerase I Promoter Opening" xref: Reactome:73762 "RNA Polymerase I Transcription Initiation" xref: Reactome:73772 "RNA Polymerase I Promoter Escape" xref: Reactome:73854 "RNA Polymerase I Promoter Clearance" is_a: GO:0006352 ! transcription initiation, DNA-dependent relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0006362 name: transcription elongation from RNA polymerase I promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol I promoter" EXACT [] xref: Reactome:1253039 "RNA Polymerase I Chain Elongation" xref: Reactome:1279971 "RNA Polymerase I Chain Elongation" xref: Reactome:1298860 "RNA Polymerase I Chain Elongation" xref: Reactome:1326544 "RNA Polymerase I Chain Elongation" xref: Reactome:1352656 "RNA Polymerase I Chain Elongation" xref: Reactome:1392893 "RNA Polymerase I Chain Elongation" xref: Reactome:1417363 "RNA Polymerase I Chain Elongation" xref: Reactome:1450464 "RNA Polymerase I Chain Elongation" xref: Reactome:1470982 "RNA Polymerase I Chain Elongation" xref: Reactome:1483013 "RNA Polymerase I Chain Elongation" xref: Reactome:1532469 "RNA Polymerase I Chain Elongation" xref: Reactome:73777 "RNA Polymerase I Chain Elongation" is_a: GO:0006354 ! transcription elongation, DNA-dependent relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0006363 name: termination of RNA polymerase I transcription namespace: biological_process alt_id: GO:0019223 def: "The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit." [GOC:mah, GOC:txnOH, PMID:10684922] synonym: "RNA polymerase I transcription termination" EXACT [] synonym: "transcription termination from Pol I promoter" EXACT [] synonym: "transcription termination from RNA polymerase I promoter" EXACT [] xref: Reactome:1253040 "RNA Polymerase I Transcription Termination" xref: Reactome:1279972 "RNA Polymerase I Transcription Termination" xref: Reactome:1298861 "RNA Polymerase I Transcription Termination" xref: Reactome:1326545 "RNA Polymerase I Transcription Termination" xref: Reactome:1352657 "RNA Polymerase I Transcription Termination" xref: Reactome:1392894 "RNA Polymerase I Transcription Termination" xref: Reactome:1417364 "RNA Polymerase I Transcription Termination" xref: Reactome:1450465 "RNA Polymerase I Transcription Termination" xref: Reactome:1496777 "RNA Polymerase I Transcription Termination" xref: Reactome:1514167 "RNA Polymerase I Transcription Termination" xref: Reactome:73863 "RNA Polymerase I Transcription Termination" is_a: GO:0006353 ! transcription termination, DNA-dependent relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0006364 name: rRNA processing namespace: biological_process alt_id: GO:0006365 def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] subset: gosubset_prok synonym: "35S primary transcript processing" NARROW [] is_a: GO:0016072 ! rRNA metabolic process is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0006366 name: transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0032568 alt_id: GO:0032569 def: "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] synonym: "gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "general transcription from RNA polymerase II promoter" RELATED [] synonym: "specific transcription from RNA polymerase II promoter" RELATED [GOC:mah] synonym: "transcription from Pol II promoter" EXACT [] xref: Reactome:1252978 "RNA Polymerase II Transcription" xref: Reactome:1279908 "RNA Polymerase II Transcription" xref: Reactome:1298926 "RNA Polymerase II Transcription" xref: Reactome:1326481 "RNA Polymerase II Transcription" xref: Reactome:1352628 "RNA Polymerase II Transcription" xref: Reactome:1372823 "RNA Polymerase II Transcription" xref: Reactome:1392833 "RNA Polymerase II Transcription" xref: Reactome:1417308 "RNA Polymerase II Transcription" xref: Reactome:1450436 "RNA Polymerase II Transcription" xref: Reactome:1470925 "RNA Polymerase II Transcription" xref: Reactome:1482965 "RNA Polymerase II Transcription" xref: Reactome:1496797 "RNA Polymerase II Transcription" xref: Reactome:1514187 "RNA Polymerase II Transcription" xref: Reactome:1521023 "RNA Polymerase II Transcription" xref: Reactome:1526746 "RNA Polymerase II Transcription" xref: Reactome:1532477 "RNA Polymerase II Transcription" xref: Reactome:1536046 "RNA Polymerase II Transcription" xref: Reactome:73857 "RNA Polymerase II Transcription" is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006367 name: transcription initiation from RNA polymerase II promoter namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol II promoter" EXACT [] xref: Reactome:1253046 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1253068 "RNA Polymerase II Transcription Initiation" xref: Reactome:1279978 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1280004 "RNA Polymerase II Transcription Initiation" xref: Reactome:1326551 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1326574 "RNA Polymerase II Transcription Initiation" xref: Reactome:1352663 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1352686 "RNA Polymerase II Transcription Initiation" xref: Reactome:1372879 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1372902 "RNA Polymerase II Transcription Initiation" xref: Reactome:1392899 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1392916 "RNA Polymerase II Transcription Initiation" xref: Reactome:1417370 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1417395 "RNA Polymerase II Transcription Initiation" xref: Reactome:1450471 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1450493 "RNA Polymerase II Transcription Initiation" xref: Reactome:1470985 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1471006 "RNA Polymerase II Transcription Initiation" xref: Reactome:1483015 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1483031 "RNA Polymerase II Transcription Initiation" xref: Reactome:1496800 "RNA Polymerase II Transcription Initiation" xref: Reactome:1496818 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1514190 "RNA Polymerase II Transcription Initiation" xref: Reactome:1514212 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1521026 "RNA Polymerase II Transcription Initiation" xref: Reactome:1521052 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1526745 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1526763 "RNA Polymerase II Transcription Initiation" xref: Reactome:1532476 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:1532494 "RNA Polymerase II Transcription Initiation" xref: Reactome:167161 "HIV-1 Transcription Initiation" xref: Reactome:73779 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" xref: Reactome:75953 "RNA Polymerase II Transcription Initiation" is_a: GO:0006352 ! transcription initiation, DNA-dependent relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0006368 name: transcription elongation from RNA polymerase II promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol II promoter" EXACT [] xref: Reactome:112382 "Formation of RNA Pol II elongation complex" xref: Reactome:113418 "Formation of the Early Elongation Complex" xref: Reactome:1253064 "RNA Polymerase II Promoter Escape" xref: Reactome:1253209 "Formation of RNA Pol II elongation complex" xref: Reactome:1253210 "RNA Polymerase II Transcription Elongation" xref: Reactome:1253211 "Formation of the Early Elongation Complex" xref: Reactome:1280000 "RNA Polymerase II Promoter Escape" xref: Reactome:1280143 "Formation of RNA Pol II elongation complex" xref: Reactome:1280144 "RNA Polymerase II Transcription Elongation" xref: Reactome:1280145 "Formation of the Early Elongation Complex" xref: Reactome:1326570 "RNA Polymerase II Promoter Escape" xref: Reactome:1326715 "Formation of RNA Pol II elongation complex" xref: Reactome:1326716 "RNA Polymerase II Transcription Elongation" xref: Reactome:1326717 "Formation of the Early Elongation Complex" xref: Reactome:1352682 "RNA Polymerase II Promoter Escape" xref: Reactome:1352826 "Formation of RNA Pol II elongation complex" xref: Reactome:1352827 "RNA Polymerase II Transcription Elongation" xref: Reactome:1352828 "Formation of the Early Elongation Complex" xref: Reactome:1372898 "RNA Polymerase II Promoter Escape" xref: Reactome:1373037 "Formation of the Early Elongation Complex" xref: Reactome:1373038 "RNA Polymerase II Transcription Elongation" xref: Reactome:1393054 "Formation of the Early Elongation Complex" xref: Reactome:1393055 "RNA Polymerase II Transcription Elongation" xref: Reactome:1417391 "RNA Polymerase II Promoter Escape" xref: Reactome:1417530 "Formation of RNA Pol II elongation complex" xref: Reactome:1417531 "RNA Polymerase II Transcription Elongation" xref: Reactome:1417532 "Formation of the Early Elongation Complex" xref: Reactome:1450489 "RNA Polymerase II Promoter Escape" xref: Reactome:1450625 "Formation of the Early Elongation Complex" xref: Reactome:1450626 "RNA Polymerase II Transcription Elongation" xref: Reactome:1471002 "RNA Polymerase II Promoter Escape" xref: Reactome:1471123 "Formation of the Early Elongation Complex" xref: Reactome:1471124 "RNA Polymerase II Transcription Elongation" xref: Reactome:1483027 "RNA Polymerase II Promoter Escape" xref: Reactome:1483133 "Formation of the Early Elongation Complex" xref: Reactome:1483134 "RNA Polymerase II Transcription Elongation" xref: Reactome:1496795 "RNA Polymerase II Promoter Escape" xref: Reactome:1496856 "Formation of the Early Elongation Complex" xref: Reactome:1496857 "RNA Polymerase II Transcription Elongation" xref: Reactome:1514185 "RNA Polymerase II Promoter Escape" xref: Reactome:1514249 "Formation of the Early Elongation Complex" xref: Reactome:1514250 "RNA Polymerase II Transcription Elongation" xref: Reactome:1521021 "RNA Polymerase II Promoter Escape" xref: Reactome:1521085 "Formation of the Early Elongation Complex" xref: Reactome:1521086 "RNA Polymerase II Transcription Elongation" xref: Reactome:1526759 "RNA Polymerase II Promoter Escape" xref: Reactome:1526864 "Formation of the Early Elongation Complex" xref: Reactome:1526865 "RNA Polymerase II Transcription Elongation" xref: Reactome:1532490 "RNA Polymerase II Promoter Escape" xref: Reactome:1532589 "Formation of the Early Elongation Complex" xref: Reactome:1532590 "RNA Polymerase II Transcription Elongation" xref: Reactome:167169 "HIV-1 Transcription Elongation" xref: Reactome:73776 "RNA Polymerase II Promoter Escape" xref: Reactome:75955 "RNA Polymerase II Transcription Elongation" is_a: GO:0006354 ! transcription elongation, DNA-dependent relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0006369 name: termination of RNA polymerase II transcription namespace: biological_process alt_id: GO:0019224 def: "The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed." [GOC:mah, GOC:txnOH] synonym: "RNA 3'-end formation by RNA polymerase II" EXACT [] synonym: "RNA polymerase II transcription termination" EXACT [] synonym: "transcription termination from Pol II promoter" EXACT [] synonym: "transcription termination from RNA polymerase II promoter" EXACT [] xref: Reactome:109688 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1252976 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1252977 "RNA Polymerase II Transcription Termination" xref: Reactome:1279906 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1279907 "RNA Polymerase II Transcription Termination" xref: Reactome:1298924 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1298925 "RNA Polymerase II Transcription Termination" xref: Reactome:1326479 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1326480 "RNA Polymerase II Transcription Termination" xref: Reactome:1352719 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1352720 "RNA Polymerase II Transcription Termination" xref: Reactome:1372821 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1372822 "RNA Polymerase II Transcription Termination" xref: Reactome:1392831 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1392832 "RNA Polymerase II Transcription Termination" xref: Reactome:1417306 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1417307 "RNA Polymerase II Transcription Termination" xref: Reactome:1470923 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1470924 "RNA Polymerase II Transcription Termination" xref: Reactome:1482963 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:1482964 "RNA Polymerase II Transcription Termination" xref: Reactome:167168 "HIV-1 Transcription Termination" xref: Reactome:73856 "RNA Polymerase II Transcription Termination" is_a: GO:0006353 ! transcription termination, DNA-dependent relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0006370 name: mRNA capping namespace: biological_process def: "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] synonym: "5' end capping" BROAD [] synonym: "5' mRNA capping" EXACT [] synonym: "5'-end mRNA processing" EXACT [] synonym: "5'-end processing" BROAD [] xref: Reactome:1253090 "mRNA Capping" xref: Reactome:1280025 "mRNA Capping" xref: Reactome:1298911 "mRNA Capping" xref: Reactome:1326595 "mRNA Capping" xref: Reactome:1352706 "mRNA Capping" xref: Reactome:1372922 "mRNA Capping" xref: Reactome:1392938 "mRNA Capping" xref: Reactome:1417415 "mRNA Capping" xref: Reactome:1450512 "mRNA Capping" xref: Reactome:1471015 "mRNA Capping" xref: Reactome:1483037 "mRNA Capping" xref: Reactome:1496804 "mRNA Capping" xref: Reactome:1514194 "mRNA Capping" xref: Reactome:1521034 "mRNA Capping" xref: Reactome:1526770 "mRNA Capping" xref: Reactome:1532498 "mRNA Capping" xref: Reactome:72086 "mRNA Capping" is_a: GO:0006397 ! mRNA processing is_a: GO:0009452 ! RNA capping [Term] id: GO:0006371 name: mRNA splicing namespace: biological_process def: "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents several different processes. is_obsolete: true consider: GO:0000372 consider: GO:0000373 consider: GO:0000374 consider: GO:0000394 consider: GO:0000398 [Term] id: GO:0006372 name: lariat formation, 5'-splice site cleavage namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true consider: GO:0000350 consider: GO:0000386 [Term] id: GO:0006373 name: 3'-splice site cleavage, exon ligation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true consider: GO:0000386 consider: GO:0000388 consider: GO:0000393 [Term] id: GO:0006376 name: mRNA splice site selection namespace: biological_process def: "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] synonym: "spliceosomal commitment complex biosynthesis" NARROW [] synonym: "spliceosomal commitment complex formation" NARROW [] synonym: "spliceosomal E complex biosynthesis" NARROW [] synonym: "spliceosomal E complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosome assembly [Term] id: GO:0006377 name: MATa1 (A1) pre-mRNA splicing namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene. is_obsolete: true consider: GO:0000244 [Term] id: GO:0006378 name: mRNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cleavage and polyadenylylation specificity factor activity" NARROW [] synonym: "mRNA polyadenylylation" EXACT [] is_a: GO:0031124 ! mRNA 3'-end processing is_a: GO:0043631 ! RNA polyadenylation [Term] id: GO:0006379 name: mRNA cleavage namespace: biological_process def: "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] subset: gosubset_prok synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] synonym: "cleavage stimulation factor activity" RELATED [] synonym: "pre-mRNA cleavage factor activity" RELATED [] is_a: GO:0006397 ! mRNA processing is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0006380 name: poly-A binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0008143 [Term] id: GO:0006382 name: adenosine to inosine editing namespace: biological_process def: "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837] subset: gosubset_prok xref: Reactome:1253044 "mRNA Editing: A to I Conversion" xref: Reactome:1279976 "mRNA Editing: A to I Conversion" xref: Reactome:1298867 "mRNA Editing: A to I Conversion" xref: Reactome:1326549 "mRNA Editing: A to I Conversion" xref: Reactome:1352661 "mRNA Editing: A to I Conversion" xref: Reactome:1372877 "mRNA Editing: A to I Conversion" xref: Reactome:1392897 "mRNA Editing: A to I Conversion" xref: Reactome:1417368 "mRNA Editing: A to I Conversion" xref: Reactome:1450469 "mRNA Editing: A to I Conversion" xref: Reactome:1471030 "mRNA Editing: A to I Conversion" xref: Reactome:75064 "mRNA Editing: A to I Conversion" is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0006383 name: transcription from RNA polymerase III promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl] subset: gosubset_prok synonym: "transcription from Pol III promoter" EXACT [] xref: Reactome:112054 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:112055 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:112149 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:112153 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:112155 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:112156 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:113442 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:113446 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:113451 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:113705 "RNA Polymerase III Productive Transcription" xref: Reactome:1229958 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:1231358 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:1231359 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:1231377 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1231380 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:1231381 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1231382 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:1231493 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1231494 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1231497 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1231555 "RNA Polymerase III Productive Transcription" xref: Reactome:1253079 "RNA Polymerase III Transcription" xref: Reactome:1257738 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:1259117 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:1259118 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:1259136 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1259139 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:1259140 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1259141 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:1259263 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1259264 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1259267 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1259318 "RNA Polymerase III Productive Transcription" xref: Reactome:1280014 "RNA Polymerase III Transcription" xref: Reactome:1284678 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1284679 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1284682 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1284709 "RNA Polymerase III Productive Transcription" xref: Reactome:1298901 "RNA Polymerase III Transcription" xref: Reactome:1303773 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:1305041 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:1305042 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:1305060 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1305063 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:1305064 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1305065 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:1305180 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1305181 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1305184 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1305220 "RNA Polymerase III Productive Transcription" xref: Reactome:1326584 "RNA Polymerase III Transcription" xref: Reactome:1331245 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:1332621 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:1332622 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:1332640 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1332643 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:1332644 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1332645 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:1332771 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1332772 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1332775 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1332830 "RNA Polymerase III Productive Transcription" xref: Reactome:1352696 "RNA Polymerase III Transcription" xref: Reactome:1356185 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:1357165 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:1357166 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:1357184 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1357187 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:1357188 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1357189 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:1357287 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1357288 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1357291 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1357313 "RNA Polymerase III Productive Transcription" xref: Reactome:1372913 "RNA Polymerase III Transcription" xref: Reactome:1377194 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:1378223 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:1378224 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:1378242 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1378245 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:1378246 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1378247 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:1378332 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1378333 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1378336 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1378357 "RNA Polymerase III Productive Transcription" xref: Reactome:1392928 "RNA Polymerase III Transcription" xref: Reactome:1397385 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:1398590 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:1398591 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:1398609 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1398614 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:1398615 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1398616 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:1398742 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1398743 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1398746 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1398802 "RNA Polymerase III Productive Transcription" xref: Reactome:1417403 "RNA Polymerase III Transcription" xref: Reactome:1423437 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:1425060 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:1425061 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:1425079 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1425082 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:1425083 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1425084 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:1425232 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1425233 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1425236 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1425280 "RNA Polymerase III Productive Transcription" xref: Reactome:1450503 "RNA Polymerase III Transcription" xref: Reactome:1455920 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:1456786 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:1456788 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1456790 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:1456791 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1456906 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1456907 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1456910 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1456932 "RNA Polymerase III Productive Transcription" xref: Reactome:1471013 "RNA Polymerase III Transcription" xref: Reactome:1475390 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1475395 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1475505 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1475506 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1475509 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1475542 "RNA Polymerase III Productive Transcription" xref: Reactome:1483130 "RNA Polymerase III Transcription" xref: Reactome:1488580 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1488585 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1488797 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1488798 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1488801 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1488828 "RNA Polymerase III Productive Transcription" xref: Reactome:1496853 "RNA Polymerase III Transcription" xref: Reactome:1503386 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:1503391 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:1503581 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1503582 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1503585 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1503606 "RNA Polymerase III Productive Transcription" xref: Reactome:1514246 "RNA Polymerase III Transcription" xref: Reactome:1517334 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1517335 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1517338 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1517354 "RNA Polymerase III Productive Transcription" xref: Reactome:1521033 "RNA Polymerase III Transcription" xref: Reactome:1526768 "RNA Polymerase III Transcription" xref: Reactome:1529977 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:1529978 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:1529981 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:1529989 "RNA Polymerase III Productive Transcription" xref: Reactome:1532592 "RNA Polymerase III Transcription" xref: Reactome:74158 "RNA Polymerase III Transcription" xref: Reactome:76060 "RNA Polymerase III Promoter Opening at Type 1 Promoters" is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006384 name: transcription initiation from RNA polymerase III promoter namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol III promoter" EXACT [] is_a: GO:0006352 ! transcription initiation, DNA-dependent relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0006385 name: transcription elongation from RNA polymerase III promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol III promoter" EXACT [] xref: Reactome:1253214 "RNA Polymerase III Chain Elongation" xref: Reactome:1280148 "RNA Polymerase III Chain Elongation" xref: Reactome:1299024 "RNA Polymerase III Chain Elongation" xref: Reactome:1326720 "RNA Polymerase III Chain Elongation" xref: Reactome:1352831 "RNA Polymerase III Chain Elongation" xref: Reactome:1373041 "RNA Polymerase III Chain Elongation" xref: Reactome:1393056 "RNA Polymerase III Chain Elongation" xref: Reactome:1417535 "RNA Polymerase III Chain Elongation" xref: Reactome:1450629 "RNA Polymerase III Chain Elongation" xref: Reactome:1471127 "RNA Polymerase III Chain Elongation" xref: Reactome:1483137 "RNA Polymerase III Chain Elongation" xref: Reactome:1496858 "RNA Polymerase III Chain Elongation" xref: Reactome:1514251 "RNA Polymerase III Chain Elongation" xref: Reactome:1521088 "RNA Polymerase III Chain Elongation" xref: Reactome:1526866 "RNA Polymerase III Chain Elongation" xref: Reactome:1532593 "RNA Polymerase III Chain Elongation" xref: Reactome:73780 "RNA Polymerase III Chain Elongation" is_a: GO:0006354 ! transcription elongation, DNA-dependent relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0006386 name: termination of RNA polymerase III transcription namespace: biological_process alt_id: GO:0019225 def: "The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues." [GOC:mah, PMID:12944462] synonym: "RNA polymerase III transcription termination" EXACT [] synonym: "transcription termination from Pol III promoter" EXACT [] synonym: "transcription termination from RNA polymerase III promoter" EXACT [] xref: Reactome:112466 "RNA Polymerase III Transcriptional Pause at Terminator Sequence" xref: Reactome:112480 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:113454 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1231535 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1253215 "RNA Polymerase III Transcription Termination" xref: Reactome:1259290 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1280149 "RNA Polymerase III Transcription Termination" xref: Reactome:1284698 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1299025 "RNA Polymerase III Transcription Termination" xref: Reactome:1305200 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1326721 "RNA Polymerase III Transcription Termination" xref: Reactome:1332810 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1352832 "RNA Polymerase III Transcription Termination" xref: Reactome:1357304 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1373042 "RNA Polymerase III Transcription Termination" xref: Reactome:1378349 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1393057 "RNA Polymerase III Transcription Termination" xref: Reactome:1398773 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1417536 "RNA Polymerase III Transcription Termination" xref: Reactome:1425256 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1450630 "RNA Polymerase III Transcription Termination" xref: Reactome:1456919 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1471128 "RNA Polymerase III Transcription Termination" xref: Reactome:1475523 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1483138 "RNA Polymerase III Transcription Termination" xref: Reactome:1488823 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1496859 "RNA Polymerase III Transcription Termination" xref: Reactome:1503601 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1514252 "RNA Polymerase III Transcription Termination" xref: Reactome:1517343 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1521089 "RNA Polymerase III Transcription Termination" xref: Reactome:1526867 "RNA Polymerase III Transcription Termination" xref: Reactome:1529986 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:1532594 "RNA Polymerase III Transcription Termination" xref: Reactome:73980 "RNA Polymerase III Transcription Termination" is_a: GO:0006353 ! transcription termination, DNA-dependent relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0006387 name: snRNA capping namespace: biological_process def: "The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript." [GOC:mah] is_a: GO:0009452 ! RNA capping is_a: GO:0016180 ! snRNA processing [Term] id: GO:0006388 name: tRNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290] comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. subset: gosubset_prok synonym: "tRNA-Y splicing" NARROW [] is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation is_a: GO:0008033 ! tRNA processing [Term] id: GO:0006389 name: tRNA-Y splicing namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA. is_obsolete: true consider: GO:0006388 [Term] id: GO:0006390 name: transcription from mitochondrial promoter namespace: biological_process def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl] synonym: "mitochondrial transcription" EXACT [] xref: Reactome:1253330 "Transcription from mitochondrial promoters" xref: Reactome:1280268 "Transcription from mitochondrial promoters" xref: Reactome:1299125 "Transcription from mitochondrial promoters" xref: Reactome:1326846 "Transcription from mitochondrial promoters" xref: Reactome:1352939 "Transcription from mitochondrial promoters" xref: Reactome:1373146 "Transcription from mitochondrial promoters" xref: Reactome:1393162 "Transcription from mitochondrial promoters" xref: Reactome:1417647 "Transcription from mitochondrial promoters" xref: Reactome:1450748 "Transcription from mitochondrial promoters" xref: Reactome:1471189 "Transcription from mitochondrial promoters" xref: Reactome:1483182 "Transcription from mitochondrial promoters" xref: Reactome:75944 "Transcription from mitochondrial promoters" is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006351 ! transcription, DNA-dependent is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0006391 name: transcription initiation from mitochondrial promoter namespace: biological_process def: "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase." [GOC:mah] xref: Reactome:1253329 "Mitochondrial transcription initiation" xref: Reactome:1280267 "Mitochondrial transcription initiation" xref: Reactome:1299124 "Mitochondrial transcription initiation" xref: Reactome:1326845 "Mitochondrial transcription initiation" xref: Reactome:1352938 "Mitochondrial transcription initiation" xref: Reactome:1373145 "Mitochondrial transcription initiation" xref: Reactome:1393161 "Mitochondrial transcription initiation" xref: Reactome:1417646 "Mitochondrial transcription initiation" xref: Reactome:1450747 "Mitochondrial transcription initiation" xref: Reactome:1471188 "Mitochondrial transcription initiation" xref: Reactome:1483181 "Mitochondrial transcription initiation" xref: Reactome:163282 "Mitochondrial transcription initiation" is_a: GO:0006352 ! transcription initiation, DNA-dependent relationship: part_of GO:0006390 ! transcription from mitochondrial promoter [Term] id: GO:0006392 name: transcription elongation from mitochondrial promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from mitochondrial promoter" EXACT [] is_a: GO:0006354 ! transcription elongation, DNA-dependent relationship: part_of GO:0006390 ! transcription from mitochondrial promoter [Term] id: GO:0006393 name: termination of mitochondrial transcription namespace: biological_process def: "The process in which the synthesis of an RNA molecule using a mitochondrial DNA template is completed." [GOC:mah] synonym: "mitochondrial transcription termination" EXACT [] synonym: "RNA transcription termination from mitochondrial promoter" EXACT [] xref: Reactome:1253331 "Mitochondrial transcription termination" xref: Reactome:1280269 "Mitochondrial transcription termination" xref: Reactome:1299126 "Mitochondrial transcription termination" xref: Reactome:1326847 "Mitochondrial transcription termination" xref: Reactome:1352940 "Mitochondrial transcription termination" xref: Reactome:1417648 "Mitochondrial transcription termination" xref: Reactome:1450749 "Mitochondrial transcription termination" xref: Reactome:163316 "Mitochondrial transcription termination" is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006353 ! transcription termination, DNA-dependent relationship: part_of GO:0006390 ! transcription from mitochondrial promoter [Term] id: GO:0006396 name: RNA processing namespace: biological_process alt_id: GO:0006394 def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Post-transcriptional_modification is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006397 name: mRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "mRNA maturation" RELATED [] xref: Reactome:1253101 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1280036 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1298921 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1326606 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1352717 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1372933 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1392949 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1417426 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1450523 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1471027 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1483048 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1514204 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:1521043 "Processing of Capped Intronless Pre-mRNA" xref: Reactome:75067 "Processing of Capped Intronless Pre-mRNA" is_a: GO:0006396 ! RNA processing is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0006398 name: histone mRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a histone mRNA molecule." [GOC:mah] synonym: "histone mRNA 3' end processing" EXACT [] is_a: GO:0008334 ! histone mRNA metabolic process is_a: GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0006399 name: tRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pombe subset: gosubset_prok synonym: "tRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0006400 name: tRNA modification namespace: biological_process alt_id: GO:0016549 def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. subset: gosubset_prok synonym: "tRNA editing" NARROW [GOC:hjd] is_a: GO:0008033 ! tRNA processing is_a: GO:0009451 ! RNA modification [Term] id: GO:0006401 name: RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "RNA breakdown" EXACT [] synonym: "RNA catabolism" EXACT [] synonym: "RNA degradation" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0006402 name: mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mRNA breakdown" EXACT [] synonym: "mRNA catabolism" EXACT [] synonym: "mRNA decay" RELATED [GOC:ascb_2010, GOC:dph, GOC:tb] synonym: "mRNA degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0006403 name: RNA localization namespace: biological_process def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] subset: gosubset_prok synonym: "establishment and maintenance of RNA localization" EXACT [] synonym: "RNA localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006404 name: RNA import into nucleus namespace: biological_process def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma] synonym: "RNA import into cell nucleus" EXACT [] synonym: "RNA transport from cytoplasm to nucleus" EXACT [] synonym: "RNA-nucleus import" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051170 ! nuclear import [Term] id: GO:0006405 name: RNA export from nucleus namespace: biological_process def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "RNA export from cell nucleus" EXACT [] synonym: "RNA export out of nucleus" EXACT [] synonym: "RNA transport from nucleus to cytoplasm" EXACT [] synonym: "RNA-nucleus export" EXACT [] xref: Reactome:1232726 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1232729 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:1232738 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1232867 "Recruitment of TAP to the EJC" xref: Reactome:1260422 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1260425 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:1260434 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1260548 "Recruitment of TAP to the EJC" xref: Reactome:1306354 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1306357 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:1306366 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1306492 "Recruitment of TAP to the EJC" xref: Reactome:1333870 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1333873 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:1333876 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1334004 "Recruitment of TAP to the EJC" xref: Reactome:1399838 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1399841 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:1399850 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1399892 "Recruitment of TAP to the EJC" xref: Reactome:1426947 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1426950 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:1426954 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1427148 "Recruitment of TAP to the EJC" xref: Reactome:1457398 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1457401 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:1457405 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:1457453 "Recruitment of TAP to the EJC" xref: Reactome:158441 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:158447 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:158481 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:159101 "Recruitment of TAP to the EJC" is_a: GO:0050658 ! RNA transport is_a: GO:0051168 ! nuclear export [Term] id: GO:0006406 name: mRNA export from nucleus namespace: biological_process def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "mRNA export from cell nucleus" EXACT [] synonym: "mRNA export out of nucleus" EXACT [] synonym: "mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "mRNA-nucleus export" EXACT [] xref: Reactome:111439 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:1229642 "Transport of the export-competent complex through the NPC" xref: Reactome:1229645 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:1230158 "Docking of Mature Replication Dependent Histone mRNA with the NPC" xref: Reactome:1230172 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" xref: Reactome:1231014 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:1232741 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:1232862 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:1232865 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:1253047 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1253048 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1253104 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:1257401 "Transport of the export-competent complex through the NPC" xref: Reactome:1257404 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:1257967 "Docking of Mature Replication Dependent Histone mRNA with the NPC" xref: Reactome:1257981 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" xref: Reactome:1258794 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:1260437 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:1260543 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:1260546 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:1279979 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1279980 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1280039 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:1283084 "Transport of the export-competent complex through the NPC" xref: Reactome:1298870 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1298871 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1303462 "Transport of the export-competent complex through the NPC" xref: Reactome:1303465 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:1304005 "Docking of Mature Replication Dependent Histone mRNA with the NPC" xref: Reactome:1304019 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" xref: Reactome:1304732 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:1306369 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:1306487 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:1306490 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:1326552 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1326553 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1326609 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:1330922 "Transport of the export-competent complex through the NPC" xref: Reactome:1330925 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:1331468 "Docking of Mature Replication Dependent Histone mRNA with the NPC" xref: Reactome:1331479 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" xref: Reactome:1332368 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:1333879 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:1333999 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:1334002 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:1352664 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1352665 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1352722 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:1355920 "Transport of the export-competent complex through the NPC" xref: Reactome:1372880 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1372881 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1376893 "Transport of the export-competent complex through the NPC" xref: Reactome:1392900 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1392901 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1397077 "Transport of the export-competent complex through the NPC" xref: Reactome:1397080 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:1397639 "Docking of Mature Replication Dependent Histone mRNA with the NPC" xref: Reactome:1397653 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" xref: Reactome:1398306 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:1399853 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:1399887 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:1399890 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:1417371 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1417372 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1417429 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:1423088 "Transport of the export-competent complex through the NPC" xref: Reactome:1423091 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:1426957 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:1427143 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:1427146 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:1450472 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1450473 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1450709 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:1455401 "Transport of the export-competent complex through the NPC" xref: Reactome:1455404 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:1457408 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:1457448 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:1457451 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:1470986 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:1470987 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:1471172 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:158484 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:159046 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:159050 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:159234 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:72202 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:75096 "Docking of the TAP:EJC Complex with the NPC" xref: Reactome:75097 "Transport of the export-competent complex through the NPC" xref: Reactome:75098 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:77587 "Docking of Mature Replication Dependent Histone mRNA with the NPC" xref: Reactome:77594 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051028 ! mRNA transport [Term] id: GO:0006407 name: rRNA export from nucleus namespace: biological_process def: "The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins." [GOC:ma, GOC:mah] synonym: "rRNA export from cell nucleus" EXACT [] synonym: "rRNA export out of nucleus" EXACT [] synonym: "rRNA transport from nucleus to cytoplasm" EXACT [] synonym: "rRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051029 ! rRNA transport relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0006408 name: snRNA export from nucleus namespace: biological_process def: "The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "snRNA export from cell nucleus" EXACT [] synonym: "snRNA export out of nucleus" EXACT [] synonym: "snRNA transport from nucleus to cytoplasm" EXACT [] synonym: "snRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051030 ! snRNA transport [Term] id: GO:0006409 name: tRNA export from nucleus namespace: biological_process def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "tRNA export from cell nucleus" EXACT [] synonym: "tRNA export out of nucleus" EXACT [] synonym: "tRNA transport from nucleus to cytoplasm" EXACT [] synonym: "tRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051031 ! tRNA transport [Term] id: GO:0006410 name: transcription, RNA-dependent namespace: biological_process def: "OBSOLETE: The cellular synthesis of DNA on a template of RNA." [GOC:jl] comment: This term was obsoleted because the name and the definition mean two completely different things: 1) "transcription, RNA-dependent", i.e. RNA-dependent production of an RNA transcript and 2) "reverse transcription", i.e. RNA-dependent DNA synthesis. is_obsolete: true [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [GOC:curators] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Reactome:1252983 "Translation" xref: Reactome:1279913 "Translation" xref: Reactome:1298812 "Translation" xref: Reactome:1326486 "Translation" xref: Reactome:1352596 "Translation" xref: Reactome:1372828 "Translation" xref: Reactome:1392838 "Translation" xref: Reactome:1417313 "Translation" xref: Reactome:1450399 "Translation" xref: Reactome:1470930 "Translation" xref: Reactome:1482970 "Translation" xref: Reactome:1496743 "Translation" xref: Reactome:1514133 "Translation" xref: Reactome:1520958 "Translation" xref: Reactome:1526711 "Translation" xref: Reactome:1532434 "Translation" xref: Reactome:1535987 "Translation" xref: Reactome:1538030 "Translation" xref: Reactome:72766 "Translation" xref: Wikipedia:Translation_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0044267 ! cellular protein metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006413 name: translational initiation namespace: biological_process alt_id: GO:0006440 alt_id: GO:0006454 def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] subset: gosubset_prok synonym: "biopolymerisation" BROAD [] synonym: "biopolymerization" BROAD [] synonym: "protein synthesis initiation" BROAD [] synonym: "translation initiation" EXACT [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0006412 ! translation [Term] id: GO:0006414 name: translational elongation namespace: biological_process alt_id: GO:0006442 alt_id: GO:0006455 def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] subset: gosubset_prok synonym: "protein synthesis elongation" BROAD [] synonym: "translation elongation" EXACT [] xref: Reactome:1253283 "Eukaryotic Translation Elongation" xref: Reactome:1280219 "Eukaryotic Translation Elongation" xref: Reactome:1299081 "Eukaryotic Translation Elongation" xref: Reactome:1326796 "Eukaryotic Translation Elongation" xref: Reactome:1352897 "Eukaryotic Translation Elongation" xref: Reactome:1373101 "Eukaryotic Translation Elongation" xref: Reactome:1393120 "Eukaryotic Translation Elongation" xref: Reactome:1417607 "Eukaryotic Translation Elongation" xref: Reactome:1450698 "Eukaryotic Translation Elongation" xref: Reactome:1471161 "Eukaryotic Translation Elongation" xref: Reactome:1483161 "Eukaryotic Translation Elongation" xref: Reactome:1496873 "Eukaryotic Translation Elongation" xref: Reactome:1514266 "Eukaryotic Translation Elongation" xref: Reactome:1521115 "Eukaryotic Translation Elongation" xref: Reactome:1526877 "Eukaryotic Translation Elongation" xref: Reactome:1532607 "Eukaryotic Translation Elongation" xref: Reactome:1536060 "Eukaryotic Translation Elongation" xref: Reactome:1538029 "Eukaryotic Translation Elongation" xref: Reactome:156842 "Eukaryotic Translation Elongation" is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: part_of GO:0006412 ! translation [Term] id: GO:0006415 name: translational termination namespace: biological_process alt_id: GO:0006443 alt_id: GO:0006456 def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] subset: gosubset_prok synonym: "protein synthesis termination" BROAD [] synonym: "translation termination" EXACT [] synonym: "translational complex disassembly" EXACT [] xref: Reactome:1232366 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1232369 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1232370 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1253274 "Eukaryotic Translation Termination" xref: Reactome:1260050 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1260053 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1280210 "Eukaryotic Translation Termination" xref: Reactome:1305991 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1305994 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1305995 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1326786 "Eukaryotic Translation Termination" xref: Reactome:1379007 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1379010 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1379011 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1393111 "Eukaryotic Translation Termination" xref: Reactome:1399507 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1399510 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1399511 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:141667 "GTP bound eRF3:eRF1 complex binds the peptidyl-tRNA:mRNA:Ribosome complex" xref: Reactome:141671 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:141673 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:141687 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:141691 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:141696 "Eukaryotic Translation Termination" xref: Reactome:141698 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1417597 "Eukaryotic Translation Termination" xref: Reactome:1426471 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1426474 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1426475 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1450688 "Eukaryotic Translation Termination" xref: Reactome:1457206 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1457209 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1457210 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1471152 "Eukaryotic Translation Termination" xref: Reactome:1475665 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1475668 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1475669 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1483155 "Eukaryotic Translation Termination" xref: Reactome:1489009 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1489012 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1489013 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1496869 "Eukaryotic Translation Termination" xref: Reactome:1503824 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1503827 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1503828 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1514262 "Eukaryotic Translation Termination" xref: Reactome:1517481 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1517484 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1517485 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1521106 "Eukaryotic Translation Termination" xref: Reactome:1526873 "Eukaryotic Translation Termination" xref: Reactome:1530028 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1530031 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1530032 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1532601 "Eukaryotic Translation Termination" xref: Reactome:1534566 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:1534569 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:1534570 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:1536056 "Eukaryotic Translation Termination" xref: Reactome:72764 "Eukaryotic Translation Termination" is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0006412 ! translation [Term] id: GO:0006417 name: regulation of translation namespace: biological_process alt_id: GO:0006445 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] subset: gosubset_prok synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0006412 ! translation [Term] id: GO:0006418 name: tRNA aminoacylation for protein translation namespace: biological_process def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] subset: gosubset_prok synonym: "tRNA charging" NARROW [] xref: MetaCyc:TRNA-CHARGING-PWY xref: Reactome:1252965 "Cytosolic tRNA aminoacylation" xref: Reactome:1252966 "tRNA Aminoacylation" xref: Reactome:1253648 "Mitochondrial tRNA aminoacylation" xref: Reactome:1279895 "Cytosolic tRNA aminoacylation" xref: Reactome:1279896 "tRNA Aminoacylation" xref: Reactome:1280579 "Mitochondrial tRNA aminoacylation" xref: Reactome:1298806 "Cytosolic tRNA aminoacylation" xref: Reactome:1298807 "tRNA Aminoacylation" xref: Reactome:1299409 "Mitochondrial tRNA aminoacylation" xref: Reactome:1326468 "Cytosolic tRNA aminoacylation" xref: Reactome:1326469 "tRNA Aminoacylation" xref: Reactome:1327165 "Mitochondrial tRNA aminoacylation" xref: Reactome:1352582 "Cytosolic tRNA aminoacylation" xref: Reactome:1352583 "tRNA Aminoacylation" xref: Reactome:1353260 "Mitochondrial tRNA aminoacylation" xref: Reactome:1372810 "Cytosolic tRNA aminoacylation" xref: Reactome:1372811 "tRNA Aminoacylation" xref: Reactome:1373434 "Mitochondrial tRNA aminoacylation" xref: Reactome:1392822 "Cytosolic tRNA aminoacylation" xref: Reactome:1392823 "tRNA Aminoacylation" xref: Reactome:1393459 "Mitochondrial tRNA aminoacylation" xref: Reactome:1417295 "Cytosolic tRNA aminoacylation" xref: Reactome:1417296 "tRNA Aminoacylation" xref: Reactome:1417960 "Mitochondrial tRNA aminoacylation" xref: Reactome:1450385 "Cytosolic tRNA aminoacylation" xref: Reactome:1450386 "tRNA Aminoacylation" xref: Reactome:1451045 "Mitochondrial tRNA aminoacylation" xref: Reactome:1470912 "Cytosolic tRNA aminoacylation" xref: Reactome:1470913 "tRNA Aminoacylation" xref: Reactome:1471414 "Mitochondrial tRNA aminoacylation" xref: Reactome:1482952 "Cytosolic tRNA aminoacylation" xref: Reactome:1482953 "tRNA Aminoacylation" xref: Reactome:1483366 "Mitochondrial tRNA aminoacylation" xref: Reactome:1497031 "Cytosolic tRNA aminoacylation" xref: Reactome:1497032 "tRNA Aminoacylation" xref: Reactome:1497033 "Mitochondrial tRNA aminoacylation" xref: Reactome:1514418 "Cytosolic tRNA aminoacylation" xref: Reactome:1514419 "tRNA Aminoacylation" xref: Reactome:1514420 "Mitochondrial tRNA aminoacylation" xref: Reactome:1520952 "Cytosolic tRNA aminoacylation" xref: Reactome:1520953 "tRNA Aminoacylation" xref: Reactome:1521285 "Mitochondrial tRNA aminoacylation" xref: Reactome:1526702 "Cytosolic tRNA aminoacylation" xref: Reactome:1526703 "tRNA Aminoacylation" xref: Reactome:1526987 "Mitochondrial tRNA aminoacylation" xref: Reactome:1532428 "Cytosolic tRNA aminoacylation" xref: Reactome:1532429 "tRNA Aminoacylation" xref: Reactome:1532727 "Mitochondrial tRNA aminoacylation" xref: Reactome:1536123 "Cytosolic tRNA aminoacylation" xref: Reactome:1536124 "tRNA Aminoacylation" xref: Reactome:1536125 "Mitochondrial tRNA aminoacylation" xref: Reactome:1538085 "Cytosolic tRNA aminoacylation" xref: Reactome:1538086 "tRNA Aminoacylation" xref: Reactome:1538087 "Mitochondrial tRNA aminoacylation" xref: Reactome:1539356 "Cytosolic tRNA aminoacylation" xref: Reactome:1539357 "tRNA Aminoacylation" xref: Reactome:1539359 "Mitochondrial tRNA aminoacylation" xref: Reactome:1540366 "Cytosolic tRNA aminoacylation" xref: Reactome:1540367 "tRNA Aminoacylation" xref: Reactome:1540369 "Mitochondrial tRNA aminoacylation" xref: Reactome:379716 "Cytosolic tRNA aminoacylation" xref: Reactome:379724 "tRNA Aminoacylation" xref: Reactome:379726 "Mitochondrial tRNA aminoacylation" is_a: GO:0043039 ! tRNA aminoacylation relationship: part_of GO:0006412 ! translation [Term] id: GO:0006419 name: alanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006420 name: arginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006421 name: asparaginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006422 name: aspartyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006423 name: cysteinyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006424 name: glutamyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006425 name: glutaminyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006426 name: glycyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006427 name: histidyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006428 name: isoleucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006429 name: leucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006430 name: lysyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006431 name: methionyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006432 name: phenylalanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006433 name: prolyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006434 name: seryl-tRNA aminoacylation namespace: biological_process def: "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006435 name: threonyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006436 name: tryptophanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006437 name: tyrosyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006438 name: valyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006439 name: aminoacyl-tRNA hydrolase reaction namespace: biological_process def: "OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA." [ISBN:019879276X] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0004045 [Term] id: GO:0006441 name: binding to mRNA cap namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0000339 [Term] id: GO:0006446 name: regulation of translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006417 ! regulation of translation relationship: regulates GO:0006413 ! translational initiation [Term] id: GO:0006447 name: regulation of translational initiation by iron namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron." [GOC:jl] subset: gosubset_prok is_a: GO:0006446 ! regulation of translational initiation [Term] id: GO:0006448 name: regulation of translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006417 ! regulation of translation relationship: regulates GO:0006414 ! translational elongation [Term] id: GO:0006449 name: regulation of translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein complex disassembly relationship: regulates GO:0006415 ! translational termination [Term] id: GO:0006450 name: regulation of translational fidelity namespace: biological_process alt_id: GO:0000029 def: "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] subset: gosubset_prok synonym: "regulation of translational accuracy" EXACT [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0006451 name: translational readthrough namespace: biological_process def: "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg] subset: gosubset_prok synonym: "natural nonsense suppression" RELATED [] is_a: GO:0006414 ! translational elongation is_a: GO:0006417 ! regulation of translation [Term] id: GO:0006452 name: translational frameshifting namespace: biological_process def: "A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425] subset: gosubset_prok xref: Wikipedia:Translational_frameshift is_a: GO:0006417 ! regulation of translation [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: Reactome:1253676 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1253678 "Chaperonin-mediated protein folding" xref: Reactome:1280608 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1280610 "Chaperonin-mediated protein folding" xref: Reactome:1299439 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1299441 "Chaperonin-mediated protein folding" xref: Reactome:1327193 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1327195 "Chaperonin-mediated protein folding" xref: Reactome:1353288 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1353290 "Chaperonin-mediated protein folding" xref: Reactome:1373465 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1373467 "Chaperonin-mediated protein folding" xref: Reactome:1393486 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1393488 "Chaperonin-mediated protein folding" xref: Reactome:1417986 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1417988 "Chaperonin-mediated protein folding" xref: Reactome:1451073 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1451075 "Chaperonin-mediated protein folding" xref: Reactome:1471431 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1471433 "Chaperonin-mediated protein folding" xref: Reactome:1483382 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1483384 "Chaperonin-mediated protein folding" xref: Reactome:1497046 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1497048 "Chaperonin-mediated protein folding" xref: Reactome:1514433 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1514435 "Chaperonin-mediated protein folding" xref: Reactome:1521296 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1521298 "Chaperonin-mediated protein folding" xref: Reactome:1527004 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1527006 "Chaperonin-mediated protein folding" xref: Reactome:1532741 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1532743 "Chaperonin-mediated protein folding" xref: Reactome:1536126 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:1536128 "Chaperonin-mediated protein folding" xref: Reactome:389960 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:389967 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:390466 "Chaperonin-mediated protein folding" xref: Reactome:392033 "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding" xref: Reactome:532668 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" xref: Wikipedia:Protein_folding is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006458 name: 'de novo' protein folding namespace: biological_process def: "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] subset: gosubset_prok synonym: "nascent chain protein folding" EXACT [] is_a: GO:0006457 ! protein folding [Term] id: GO:0006459 name: binding unfolded ER proteins namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0005783 consider: GO:0051082 [Term] id: GO:0006460 name: peptidyl-prolyl isomerase B reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0003755 [Term] id: GO:0006461 name: protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai] subset: goslim_generic subset: goslim_pombe subset: gosubset_prok synonym: "chaperone activity" RELATED [] synonym: "protein complex formation" EXACT [] is_a: GO:0065003 ! macromolecular complex assembly is_a: GO:0071822 ! protein complex subunit organization relationship: part_of GO:0070271 ! protein complex biogenesis [Term] id: GO:0006462 name: protein complex assembly, multichaperone pathway namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown. is_obsolete: true consider: GO:0006457 consider: GO:0051131 [Term] id: GO:0006463 name: steroid hormone receptor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor." [GOC:jl, Wikipedia:Steroid_hormone_receptor] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0006464 name: protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "process resulting in protein modification" RELATED [] synonym: "protein tagging activity" RELATED [] is_a: GO:0043412 ! macromolecule modification is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006465 name: signal peptide processing namespace: biological_process def: "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194] subset: gosubset_prok synonym: "leader peptide processing" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0044267 ! cellular protein metabolic process is_a: GO:0051605 ! protein maturation by peptide bond cleavage [Term] id: GO:0006466 name: protein disulfide-isomerase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it presents a molecular function. synonym: "protein disulphide-isomerase reaction" EXACT [] is_obsolete: true replaced_by: GO:0003756 [Term] id: GO:0006467 name: protein thiol-disulfide exchange namespace: biological_process def: "Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond, according to the reaction RS-SR + R'SH = R'S-SR + RSH." [GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "disulphide bond biosynthesis" EXACT [] synonym: "disulphide bond formation" EXACT [] synonym: "protein thiol-disulphide exchange" EXACT [] is_a: GO:0006457 ! protein folding is_a: GO:0006464 ! protein modification process [Term] id: GO:0006468 name: protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: gosubset_prok synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process is_a: GO:0016310 ! phosphorylation [Term] id: GO:0006469 name: negative regulation of protein kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of protein kinase activity" EXACT [] synonym: "down-regulation of protein kinase activity" EXACT [] synonym: "downregulation of protein kinase activity" EXACT [] synonym: "inhibition of protein kinase activity" NARROW [] is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity [Term] id: GO:0006470 name: protein dephosphorylation namespace: biological_process def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb] subset: gosubset_prok synonym: "protein amino acid dephosphorylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process is_a: GO:0016311 ! dephosphorylation [Term] id: GO:0006471 name: protein ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to protein amino acids." [RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295] subset: gosubset_prok synonym: "protein amino acid ADP-ribosylation" EXACT [GOC:bf] xref: RESID:AA0040 xref: RESID:AA0168 xref: RESID:AA0169 xref: RESID:AA0231 xref: RESID:AA0237 xref: RESID:AA0295 is_a: GO:0006464 ! protein modification process [Term] id: GO:0006473 name: protein acetylation namespace: biological_process def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid acetylation" EXACT [GOC:bf] is_a: GO:0043543 ! protein acylation [Term] id: GO:0006474 name: N-terminal protein amino acid acetylation namespace: biological_process def: "The acetylation of the N-terminal amino acid of proteins." [GOC:ai] subset: gosubset_prok synonym: "N(alpha)-terminal acetylation" NARROW [PMID:11013267] is_a: GO:0006473 ! protein acetylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0006475 name: internal protein amino acid acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006473 ! protein acetylation [Term] id: GO:0006476 name: protein deacetylation namespace: biological_process def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid deacetylation" EXACT [GOC:bf] is_a: GO:0035601 ! protein deacylation [Term] id: GO:0006477 name: protein sulfation namespace: biological_process def: "The addition of a sulfate group as an ester to a protein amino acid." [GOC:curators] subset: gosubset_prok synonym: "protein amino acid sulfation" EXACT [GOC:bf] synonym: "protein amino acid sulphation" EXACT [] is_a: GO:0006464 ! protein modification process is_a: GO:0051923 ! sulfation [Term] id: GO:0006478 name: peptidyl-tyrosine sulfation namespace: biological_process def: "The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172] subset: gosubset_prok synonym: "peptidyl-tyrosine sulphation" EXACT [] xref: RESID:AA0172 is_a: GO:0006477 ! protein sulfation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0006479 name: protein methylation namespace: biological_process def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid methylation" EXACT [GOC:bf] is_a: GO:0008213 ! protein alkylation is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0006480 name: N-terminal protein amino acid methylation namespace: biological_process def: "The methylation of the N-terminal amino acid of a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0006479 ! protein methylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0006481 name: C-terminal protein methylation namespace: biological_process def: "The methylation of the C-terminal amino acid of a protein." [GOC:ai] subset: gosubset_prok synonym: "C-terminal protein amino acid methylation" EXACT [GOC:bf] is_a: GO:0006479 ! protein methylation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0006482 name: protein demethylation namespace: biological_process def: "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah] subset: gosubset_prok synonym: "protein amino acid demethylation" EXACT [GOC:bf] is_a: GO:0008214 ! protein dealkylation is_a: GO:0070988 ! demethylation [Term] id: GO:0006483 name: peptidyl-aspartic acid/asparagine hydroxylation namespace: biological_process def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. synonym: "aspartic acid/asparagine hydroxylation" EXACT [] is_obsolete: true consider: GO:0042264 consider: GO:0042265 [Term] id: GO:0006484 name: protein cysteine-thiol oxidation namespace: biological_process def: "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine." [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025] comment: This term was made obsolete because it represents a single activity. is_obsolete: true consider: GO:0003756 [Term] id: GO:0006486 name: protein glycosylation namespace: biological_process def: "A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators] subset: goslim_pombe subset: gosubset_prok synonym: "protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process is_a: GO:0043413 ! macromolecule glycosylation is_a: GO:0044262 ! cellular carbohydrate metabolic process relationship: part_of GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0006487 name: protein N-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [RESID:AA0151, RESID:AA0156, RESID:AA0327] subset: gosubset_prok synonym: "N-glycan biosynthesis" RELATED [] synonym: "N-glycan metabolism" RELATED [] synonym: "protein amino acid N-linked glycosylation" EXACT [GOC:bf] xref: RESID:AA0151 xref: RESID:AA0156 xref: RESID:AA0327 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0006488 name: dolichol-linked oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309 "Biochemical Pathways"] subset: gosubset_prok synonym: "dolichol-linked oligosaccharide anabolism" EXACT [] synonym: "dolichol-linked oligosaccharide biosynthesis" EXACT [] synonym: "dolichol-linked oligosaccharide formation" EXACT [] synonym: "dolichol-linked oligosaccharide synthesis" EXACT [] synonym: "N-linked glycan precursor biosynthesis" EXACT [PMID:8666161] synonym: "N-linked glycan precursor biosynthetic process" EXACT [PMID:8666161] synonym: "oligosaccharide-PP-dolichol assembly" EXACT [] xref: Reactome:1253316 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1280254 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1299113 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1326832 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1353390 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1373562 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1393578 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1417638 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1451174 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1471517 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1483457 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1497096 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1514483 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1521123 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1527047 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:1532779 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" xref: Reactome:446193 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" is_a: GO:0009312 ! oligosaccharide biosynthetic process relationship: part_of GO:0006487 ! protein N-linked glycosylation [Term] id: GO:0006489 name: dolichyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "dolichyl diphosphate anabolism" EXACT [] synonym: "dolichyl diphosphate biosynthesis" EXACT [] synonym: "dolichyl diphosphate formation" EXACT [] synonym: "dolichyl diphosphate synthesis" EXACT [] xref: Reactome:446199 "Synthesis of Dolichyl-phosphate" is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0019408 ! dolichol biosynthetic process is_a: GO:0046465 ! dolichyl diphosphate metabolic process relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process [Term] id: GO:0006490 name: oligosaccharide-lipid intermediate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation." [GOC:dph, GOC:hjd, GOC:isa_complete, GOC:pr, GOC:rb] subset: gosubset_prok synonym: "oligosaccharide-lipid intermediate assembly" NARROW [GOC:pr] synonym: "oligosaccharide-lipid intermediate biosynthetic process" NARROW [GOC:pr] is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:0051691 ! cellular oligosaccharide metabolic process relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process [Term] id: GO:0006491 name: N-glycan processing namespace: biological_process alt_id: GO:0006492 def: "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] subset: gosubset_prok synonym: "N-glycan catabolism" RELATED [] synonym: "N-glycan degradation" RELATED [] synonym: "N-linked glycoprotein maturation" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process relationship: part_of GO:0006487 ! protein N-linked glycosylation [Term] id: GO:0006493 name: protein O-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a sugar unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] subset: gosubset_prok synonym: "protein amino acid O-linked glycosylation" EXACT [GOC:bf] xref: RESID:AA0153 xref: RESID:AA0154 xref: RESID:AA0155 xref: RESID:AA0157 xref: RESID:AA0212 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0006494 name: protein amino acid terminal glycosylation namespace: biological_process def: "A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide." [GOC:jsg] comment: This term was made obsolete because the term name is ambiguous. subset: gosubset_prok is_obsolete: true consider: GO:0006486 [Term] id: GO:0006495 name: terminal O-glycosylation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators, GOC:jsg] comment: This term was made obsolete because there is no evidence for the existence of this process. is_obsolete: true [Term] id: GO:0006496 name: protein amino acid terminal N-glycosylation namespace: biological_process def: "The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide." [GOC:jsg] comment: This term was made obsolete because the term name is ambiguous. subset: gosubset_prok is_obsolete: true consider: GO:0006487 consider: GO:0035629 [Term] id: GO:0006497 name: protein lipidation namespace: biological_process alt_id: GO:0042050 def: "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl] comment: For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children. subset: gosubset_prok synonym: "lipid:protein modification" EXACT [] synonym: "protein amino acid lipidation" EXACT [GOC:bf] synonym: "protein lipidation" EXACT [] xref: RESID:AA0059 xref: RESID:AA0060 xref: RESID:AA0077 xref: RESID:AA0078 xref: RESID:AA0079 xref: RESID:AA0080 xref: RESID:AA0102 xref: RESID:AA0103 xref: RESID:AA0104 xref: RESID:AA0106 xref: RESID:AA0107 xref: RESID:AA0158 xref: RESID:AA0159 xref: RESID:AA0160 xref: RESID:AA0161 xref: RESID:AA0162 xref: RESID:AA0163 xref: RESID:AA0166 xref: RESID:AA0223 xref: RESID:AA0290 xref: RESID:AA0307 xref: RESID:AA0308 xref: RESID:AA0309 xref: RESID:AA0316 is_a: GO:0006464 ! protein modification process relationship: part_of GO:0042158 ! lipoprotein biosynthetic process [Term] id: GO:0006498 name: N-terminal protein lipidation namespace: biological_process def: "The covalent attachment of a lipid group to the amino terminus of a protein." [GOC:jl] subset: gosubset_prok is_a: GO:0006497 ! protein lipidation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0006499 name: N-terminal protein myristoylation namespace: biological_process def: "The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006498 ! N-terminal protein lipidation is_a: GO:0018377 ! protein myristoylation [Term] id: GO:0006500 name: N-terminal protein palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006498 ! N-terminal protein lipidation is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0006501 name: C-terminal protein lipidation namespace: biological_process def: "The covalent attachment of a lipid group to the carboxy terminus of a protein." [GOC:jl] subset: gosubset_prok xref: Reactome:1253313 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1280251 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1299110 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1326829 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1352930 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1373135 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1393151 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1417635 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1450735 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1471180 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1483172 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1496875 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1514268 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1521119 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1526885 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1532614 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:1536062 "Post-translational modification: synthesis of GPI-anchored proteins" xref: Reactome:163125 "Post-translational modification: synthesis of GPI-anchored proteins" is_a: GO:0006497 ! protein lipidation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0006502 name: C-terminal protein prenylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a prenyl group to the carboxy terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. is_obsolete: true replaced_by: GO:0018342 [Term] id: GO:0006503 name: C-terminal protein farnesylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a farnesyl group to the carboxy terminus of a protein." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. is_obsolete: true replaced_by: GO:0018343 [Term] id: GO:0006504 name: C-terminal protein geranylgeranylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl group to the carboxy terminus of a protein." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. is_obsolete: true replaced_by: GO:0018344 [Term] id: GO:0006505 name: GPI anchor metabolic process namespace: biological_process alt_id: GO:0046472 def: "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycosylphosphatidylinositol metabolic process" EXACT [] synonym: "glycosylphosphatidylinositol metabolism" EXACT [] synonym: "GPI anchor metabolism" EXACT [] synonym: "GPI/GSI anchor metabolic process" BROAD [] synonym: "GPI/GSI anchor metabolism" BROAD [] is_a: GO:0046488 ! phosphatidylinositol metabolic process [Term] id: GO:0006506 name: GPI anchor biosynthetic process namespace: biological_process alt_id: GO:0015998 def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] subset: gosubset_prok synonym: "glycosylphosphatidylinositol biosynthesis" EXACT [] synonym: "glycosylphosphatidylinositol biosynthetic process" EXACT [] synonym: "GPI anchor anabolism" EXACT [] synonym: "GPI anchor biosynthesis" EXACT [] synonym: "GPI anchor formation" EXACT [] synonym: "GPI anchor synthesis" EXACT [] synonym: "GPI/GSI anchor biosynthesis" BROAD [] synonym: "GPI/GSI anchor biosynthetic process" BROAD [] is_a: GO:0006497 ! protein lipidation is_a: GO:0006505 ! GPI anchor metabolic process is_a: GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0006507 name: GPI anchor release namespace: biological_process def: "The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane." [GOC:mah, PMID:18811934] subset: gosubset_prok is_a: GO:0006505 ! GPI anchor metabolic process [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein maturation. subset: goslim_pir subset: gosubset_prok synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Reactome:1253301 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:1280241 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:1299101 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:1326817 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:1352918 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:1373124 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:1393140 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:1417623 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:1450723 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:159782 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Wikipedia:Proteolysis is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0006509 name: membrane protein ectodomain proteolysis namespace: biological_process def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] subset: gosubset_prok synonym: "ectodomain cleavage" EXACT [PMID:18757500] synonym: "membrane protein solubilization" RELATED [] synonym: "receptor shedding" RELATED [] is_a: GO:0033619 ! membrane protein proteolysis [Term] id: GO:0006510 name: ATP-dependent proteolysis namespace: biological_process def: "OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP." [GOC:jl] comment: This term was made obsolete because it represents a molecular function. synonym: "ATP-dependent peptidolysis" EXACT [] is_obsolete: true replaced_by: GO:0004176 consider: GO:0006508 consider: GO:0051603 consider: GO:0051605 [Term] id: GO:0006511 name: ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] synonym: "ubiquitin-dependent protein breakdown" EXACT [] synonym: "ubiquitin-dependent protein catabolism" EXACT [] synonym: "ubiquitin-dependent protein degradation" EXACT [] synonym: "ubiquitin-dependent proteolysis" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0006512 name: ubiquitin cycle namespace: biological_process def: "OBSOLETE. The cyclical process by which one or more ubiquitin groups are added to (ubiquitination) and removed from (deubiquitination) a protein." [PMID:11917093] comment: This term was made obsolete because it implies that every protein that is ubiquitinated is also subsequently deubiquinitated, which is not true. Also, the process ontology does not include analogous terms for other small modifiers. is_obsolete: true [Term] id: GO:0006513 name: protein monoubiquitination namespace: biological_process def: "Addition of a single ubiquitin group to a protein." [GOC:ai] synonym: "protein monoubiquitinylation" EXACT [] synonym: "protein monoubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0006515 name: misfolded or incompletely synthesized protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl] subset: gosubset_prok synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT [] synonym: "misfolded or incompletely synthesized protein breakdown" EXACT [] synonym: "misfolded or incompletely synthesized protein catabolism" EXACT [] synonym: "misfolded or incompletely synthesized protein degradation" EXACT [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0006516 name: glycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycoprotein breakdown" EXACT [] synonym: "glycoprotein catabolism" EXACT [] synonym: "glycoprotein degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006517 name: protein deglycosylation namespace: biological_process def: "The removal of sugar residues from a glycosylated protein." [GOC:mah] subset: gosubset_prok synonym: "glycoprotein deglycosylation" EXACT [] is_a: GO:0006464 ! protein modification process is_a: GO:0006516 ! glycoprotein catabolic process [Term] id: GO:0006518 name: peptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [CHEBI:16670, GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "peptide metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006520 name: cellular amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pombe subset: gosubset_prok synonym: "amino acid and derivative metabolism" EXACT [GOC:curators] synonym: "amino acid metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid and derivative metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044106 ! cellular amine metabolic process is_a: GO:0044238 ! primary metabolic process [Term] id: GO:0006521 name: regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of amino acid metabolism" EXACT [] xref: Reactome:1253598 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:1280529 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:1327115 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:1353210 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:1373387 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:1393412 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:1417906 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:1450996 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:350562 "Regulation of ornithine decarboxylase (ODC)" is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0006522 name: alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "alanine metabolism" EXACT [] is_a: GO:0009078 ! pyruvate family amino acid metabolic process [Term] id: GO:0006523 name: alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "alanine anabolism" EXACT [] synonym: "alanine biosynthesis" EXACT [] synonym: "alanine formation" EXACT [] synonym: "alanine synthesis" EXACT [] is_a: GO:0006522 ! alanine metabolic process is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process [Term] id: GO:0006524 name: alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "alanine breakdown" EXACT [] synonym: "alanine catabolism" EXACT [] synonym: "alanine degradation" EXACT [] is_a: GO:0006522 ! alanine metabolic process is_a: GO:0009080 ! pyruvate family amino acid catabolic process [Term] id: GO:0006525 name: arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators] subset: gosubset_prok synonym: "arginine metabolism" EXACT [] xref: Wikipedia:Arginine is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006526 name: arginine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "arginine anabolism" EXACT [] synonym: "arginine biosynthesis" EXACT [] synonym: "arginine formation" EXACT [] synonym: "arginine synthesis" EXACT [] xref: MetaCyc:ARGININE-SYN4-PWY xref: MetaCyc:ARGSYN-PWY xref: MetaCyc:ARGSYNBSUB-PWY is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006527 name: arginine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators] subset: gosubset_prok synonym: "arginine breakdown" EXACT [] synonym: "arginine catabolism" EXACT [] synonym: "arginine degradation" EXACT [] is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006528 name: asparagine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "asparagine metabolism" EXACT [] xref: MetaCyc:ASPARAGINESYN-PWY is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006529 name: asparagine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "asparagine anabolism" EXACT [] synonym: "asparagine biosynthesis" EXACT [] synonym: "asparagine formation" EXACT [] synonym: "asparagine synthesis" EXACT [] is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0006530 name: asparagine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "asparagine breakdown" EXACT [] synonym: "asparagine catabolism" EXACT [] synonym: "asparagine degradation" EXACT [] is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006531 name: aspartate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aspartate metabolism" EXACT [] is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006532 name: aspartate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aspartate anabolism" EXACT [] synonym: "aspartate biosynthesis" EXACT [] synonym: "aspartate formation" EXACT [] synonym: "aspartate synthesis" EXACT [] is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0006533 name: aspartate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aspartate breakdown" EXACT [] synonym: "aspartate catabolism" EXACT [] synonym: "aspartate degradation" EXACT [] is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006534 name: cysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine metabolism" EXACT [] xref: Wikipedia:Cysteine_metabolism is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006535 name: cysteine biosynthetic process from serine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine anabolism from serine" EXACT [] synonym: "cysteine formation from serine" EXACT [] synonym: "cysteine synthesis from serine" EXACT [] xref: MetaCyc:CYSTSYN-PWY xref: Reactome:936654 "Cysteine synthesis from O-phosphoserine" xref: Reactome:936721 "Cysteine synthesis from O-acetylserine" is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0006536 name: glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate metabolism" EXACT [] synonym: "glutamic acid metabolic process" EXACT [] synonym: "glutamic acid metabolism" EXACT [] xref: Wikipedia:Glutamic_acid is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006537 name: glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate anabolism" EXACT [] synonym: "glutamate biosynthesis" EXACT [] synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate formation" EXACT [] synonym: "glutamate synthesis" EXACT [] synonym: "glutamic acid biosynthesis" EXACT [] synonym: "glutamic acid biosynthetic process" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006538 name: glutamate catabolic process namespace: biological_process alt_id: GO:0019459 def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown" EXACT [] synonym: "glutamate catabolism" EXACT [] synonym: "glutamate deamidation" RELATED [] synonym: "glutamate degradation" EXACT [] synonym: "glutamic acid catabolic process" EXACT [] synonym: "glutamic acid catabolism" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006539 name: glutamate catabolic process via 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown via 2-oxoglutarate" EXACT [] synonym: "glutamate catabolic process via 2-ketoglutarate" EXACT [] synonym: "glutamate catabolic process via alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolic process via alpha-oxoglutarate" EXACT [] synonym: "glutamate catabolism via 2-ketoglutarate" EXACT [] synonym: "glutamate catabolism via alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolism via alpha-oxoglutarate" EXACT [] synonym: "glutamate degradation via 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0006540 name: glutamate decarboxylation to succinate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438] subset: gosubset_prok synonym: "4-aminobutyrate shunt" EXACT [] synonym: "GABA shunt" EXACT [] synonym: "gamma-aminobutyrate shunt" EXACT [] xref: MetaCyc:GLUDEG-I-PWY xref: MetaCyc:PWY-4321 is_a: GO:0006105 ! succinate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0006541 name: glutamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "glutamine metabolism" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006542 name: glutamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "glutamine anabolism" EXACT [] synonym: "glutamine biosynthesis" EXACT [] synonym: "glutamine formation" EXACT [] synonym: "glutamine synthesis" EXACT [] xref: MetaCyc:GLNSYN-PWY is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006543 name: glutamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "glutamine breakdown" EXACT [] synonym: "glutamine catabolism" EXACT [] synonym: "glutamine degradation" EXACT [] is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006544 name: glycine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glycine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006545 name: glycine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glycine anabolism" EXACT [] synonym: "glycine biosynthesis" EXACT [] synonym: "glycine formation" EXACT [] synonym: "glycine synthesis" EXACT [] xref: MetaCyc:GLYCINE-SYN2-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process [Term] id: GO:0006546 name: glycine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glycine breakdown" EXACT [] synonym: "glycine catabolism" EXACT [] synonym: "glycine degradation" EXACT [] is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0006547 name: histidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "histidine metabolism" EXACT [] xref: Wikipedia:Histidine is_a: GO:0009075 ! histidine family amino acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0006548 name: histidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "histidine breakdown" EXACT [] synonym: "histidine catabolism" EXACT [] synonym: "histidine degradation" EXACT [] xref: Reactome:1252943 "Histidine catabolism" xref: Reactome:1279877 "Histidine catabolism" xref: Reactome:1298789 "Histidine catabolism" xref: Reactome:1326446 "Histidine catabolism" xref: Reactome:1352562 "Histidine catabolism" xref: Reactome:1372789 "Histidine catabolism" xref: Reactome:1392799 "Histidine catabolism" xref: Reactome:1417276 "Histidine catabolism" xref: Reactome:1450365 "Histidine catabolism" xref: Reactome:1482935 "Histidine catabolism" xref: Reactome:1496725 "Histidine catabolism" xref: Reactome:1520937 "Histidine catabolism" xref: Reactome:1540291 "Histidine catabolism" xref: Reactome:70921 "Histidine catabolism" is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009077 ! histidine family amino acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0006549 name: isoleucine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "isoleucine metabolism" EXACT [] is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0006550 name: isoleucine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "isoleucine breakdown" EXACT [] synonym: "isoleucine catabolism" EXACT [] synonym: "isoleucine degradation" EXACT [] xref: MetaCyc:ILEUDEG-PWY is_a: GO:0006549 ! isoleucine metabolic process is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0006551 name: leucine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "leucine metabolism" EXACT [] is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0006552 name: leucine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "leucine breakdown" EXACT [] synonym: "leucine catabolism" EXACT [] synonym: "leucine degradation" EXACT [] xref: MetaCyc:LEU-DEG2-PWY is_a: GO:0006551 ! leucine metabolic process is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0006553 name: lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "lysine metabolism" EXACT [] xref: Wikipedia:Lysine is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006554 name: lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "lysine breakdown" EXACT [] synonym: "lysine catabolism" EXACT [] synonym: "lysine degradation" EXACT [] xref: Reactome:1252944 "Lysine catabolism" xref: Reactome:1279878 "Lysine catabolism" xref: Reactome:1298790 "Lysine catabolism" xref: Reactome:1326447 "Lysine catabolism" xref: Reactome:1352563 "Lysine catabolism" xref: Reactome:1372790 "Lysine catabolism" xref: Reactome:1392800 "Lysine catabolism" xref: Reactome:1417277 "Lysine catabolism" xref: Reactome:1450366 "Lysine catabolism" xref: Reactome:1470903 "Lysine catabolism" xref: Reactome:1482936 "Lysine catabolism" xref: Reactome:1496726 "Lysine catabolism" xref: Reactome:1514116 "Lysine catabolism" xref: Reactome:1520938 "Lysine catabolism" xref: Reactome:1526691 "Lysine catabolism" xref: Reactome:1532420 "Lysine catabolism" xref: Reactome:1535975 "Lysine catabolism" xref: Reactome:1539233 "Lysine catabolism" xref: Reactome:1540293 "Lysine catabolism" xref: Reactome:71064 "Lysine catabolism" is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006555 name: methionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methionine and threonine metabolic process" BROAD [] synonym: "methionine and threonine metabolism" BROAD [] synonym: "methionine metabolism" EXACT [] xref: UM-BBD_pathwayID:met is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006556 name: S-adenosylmethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "S-adenosyl methionine biosynthesis" EXACT [] synonym: "S-adenosyl methionine biosynthetic process" EXACT [] synonym: "S-adenosylmethionine anabolism" EXACT [] synonym: "S-adenosylmethionine biosynthesis" EXACT [] synonym: "S-adenosylmethionine formation" EXACT [] synonym: "S-adenosylmethionine synthesis" EXACT [] synonym: "SAM biosynthetic process" EXACT [] xref: MetaCyc:SAM-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process is_a: GO:0046500 ! S-adenosylmethionine metabolic process [Term] id: GO:0006557 name: S-adenosylmethioninamine biosynthetic process namespace: biological_process alt_id: GO:0006745 def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] subset: gosubset_prok synonym: "S-adenosylmethioninamine anabolism" EXACT [] synonym: "S-adenosylmethioninamine biosynthesis" EXACT [] synonym: "S-adenosylmethioninamine formation" EXACT [] synonym: "S-adenosylmethioninamine synthesis" EXACT [] is_a: GO:0006743 ! ubiquinone metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046499 ! S-adenosylmethioninamine metabolic process [Term] id: GO:0006558 name: L-phenylalanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [CHEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-phenylalanine metabolism" EXACT [] synonym: "phenylalanine metabolic process" BROAD [] synonym: "phenylalanine metabolism" BROAD [] is_a: GO:0009072 ! aromatic amino acid family metabolic process [Term] id: GO:0006559 name: L-phenylalanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "L-phenylalanine breakdown" EXACT [] synonym: "L-phenylalanine catabolism" EXACT [] synonym: "L-phenylalanine degradation" EXACT [] synonym: "phenylalanine catabolic process" BROAD [] synonym: "phenylalanine catabolism" BROAD [] xref: Reactome:1252954 "Phenylalanine and tyrosine catabolism" xref: Reactome:1279884 "Phenylalanine and tyrosine catabolism" xref: Reactome:1298796 "Phenylalanine and tyrosine catabolism" xref: Reactome:1326457 "Phenylalanine and tyrosine catabolism" xref: Reactome:1352573 "Phenylalanine and tyrosine catabolism" xref: Reactome:1372800 "Phenylalanine and tyrosine catabolism" xref: Reactome:1392810 "Phenylalanine and tyrosine catabolism" xref: Reactome:1417283 "Phenylalanine and tyrosine catabolism" xref: Reactome:1450376 "Phenylalanine and tyrosine catabolism" xref: Reactome:1470906 "Phenylalanine and tyrosine catabolism" xref: Reactome:1482943 "Phenylalanine and tyrosine catabolism" xref: Reactome:1496729 "Phenylalanine and tyrosine catabolism" xref: Reactome:1514119 "Phenylalanine and tyrosine catabolism" xref: Reactome:1520945 "Phenylalanine and tyrosine catabolism" xref: Reactome:1537989 "Phenylalanine and tyrosine catabolism" xref: Reactome:1539240 "Phenylalanine and tyrosine catabolism" xref: Reactome:1540294 "Phenylalanine and tyrosine catabolism" xref: Reactome:71182 "Phenylalanine and tyrosine catabolism" is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0006560 name: proline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proline metabolism" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0006561 name: proline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proline anabolism" EXACT [] synonym: "proline biosynthesis" EXACT [] synonym: "proline formation" EXACT [] synonym: "proline synthesis" EXACT [] xref: MetaCyc:PROSYN-PWY xref: MetaCyc:PWY-3341 is_a: GO:0006560 ! proline metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process [Term] id: GO:0006562 name: proline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proline breakdown" EXACT [] synonym: "proline catabolism" EXACT [] synonym: "proline degradation" EXACT [] xref: Reactome:1252940 "Proline catabolism" xref: Reactome:1279874 "Proline catabolism" xref: Reactome:1326443 "Proline catabolism" xref: Reactome:1352559 "Proline catabolism" xref: Reactome:1372786 "Proline catabolism" xref: Reactome:1392796 "Proline catabolism" xref: Reactome:1417273 "Proline catabolism" xref: Reactome:1450362 "Proline catabolism" xref: Reactome:1470901 "Proline catabolism" xref: Reactome:1482933 "Proline catabolism" xref: Reactome:1496723 "Proline catabolism" xref: Reactome:1514114 "Proline catabolism" xref: Reactome:1520934 "Proline catabolism" xref: Reactome:1526688 "Proline catabolism" xref: Reactome:1532417 "Proline catabolism" xref: Reactome:1537982 "Proline catabolism" xref: Reactome:1539231 "Proline catabolism" xref: Reactome:1540289 "Proline catabolism" xref: Reactome:70688 "Proline catabolism" is_a: GO:0006560 ! proline metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0006563 name: L-serine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "L-serine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006564 name: L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "L-serine anabolism" EXACT [] synonym: "L-serine biosynthesis" EXACT [] synonym: "L-serine formation" EXACT [] synonym: "L-serine synthesis" EXACT [] xref: MetaCyc:SERSYN-PWY is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process [Term] id: GO:0006565 name: L-serine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "L-serine breakdown" EXACT [] synonym: "L-serine catabolism" EXACT [] synonym: "L-serine degradation" EXACT [] xref: MetaCyc:SERDEG-PWY is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0006566 name: threonine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methionine and threonine metabolic process" BROAD [] synonym: "methionine and threonine metabolism" BROAD [] synonym: "threonine metabolism" EXACT [] xref: UM-BBD_pathwayID:met is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006567 name: threonine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "threonine breakdown" EXACT [] synonym: "threonine catabolism" EXACT [] synonym: "threonine degradation" EXACT [] xref: MetaCyc:THREOCAT-PWY xref: UM-BBD_pathwayID:met is_a: GO:0006566 ! threonine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006568 name: tryptophan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] subset: gosubset_prok synonym: "tryptophan metabolism" EXACT [] xref: Wikipedia:Tryptophan is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process [Term] id: GO:0006569 name: tryptophan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] subset: gosubset_prok synonym: "tryptophan breakdown" EXACT [] synonym: "tryptophan catabolic process, using tryptophanase" NARROW [] synonym: "tryptophan catabolism" EXACT [] synonym: "tryptophan catabolism, using tryptophanase" NARROW [] synonym: "tryptophan degradation" EXACT [] xref: Reactome:1252955 "Tryptophan catabolism" xref: Reactome:1279885 "Tryptophan catabolism" xref: Reactome:1298797 "Tryptophan catabolism" xref: Reactome:1326458 "Tryptophan catabolism" xref: Reactome:1352574 "Tryptophan catabolism" xref: Reactome:1372801 "Tryptophan catabolism" xref: Reactome:1392811 "Tryptophan catabolism" xref: Reactome:1417284 "Tryptophan catabolism" xref: Reactome:1450377 "Tryptophan catabolism" xref: Reactome:1470907 "Tryptophan catabolism" xref: Reactome:1482944 "Tryptophan catabolism" xref: Reactome:1520946 "Tryptophan catabolism" xref: Reactome:1526694 "Tryptophan catabolism" xref: Reactome:1540295 "Tryptophan catabolism" xref: Reactome:71240 "Tryptophan catabolism" is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0046218 ! indolalkylamine catabolic process [Term] id: GO:0006570 name: tyrosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "tyrosine metabolism" EXACT [] xref: UM-BBD_pathwayID:tyr xref: Wikipedia:Tyrosine is_a: GO:0009072 ! aromatic amino acid family metabolic process [Term] id: GO:0006571 name: tyrosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:sm] subset: gosubset_prok synonym: "tyrosine anabolism" EXACT [] synonym: "tyrosine biosynthesis" EXACT [] synonym: "tyrosine formation" EXACT [] synonym: "tyrosine synthesis" EXACT [] xref: MetaCyc:PWY-3461 is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway [Term] id: GO:0006572 name: tyrosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "tyrosine breakdown" EXACT [] synonym: "tyrosine catabolism" EXACT [] synonym: "tyrosine degradation" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0006573 name: valine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "valine metabolism" EXACT [] is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0006574 name: valine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "valine breakdown" EXACT [] synonym: "valine catabolism" EXACT [] synonym: "valine degradation" EXACT [] xref: MetaCyc:VALDEG-PWY is_a: GO:0006573 ! valine metabolic process is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0006575 name: cellular modified amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [CHEBI:25359, GOC:ai] subset: gosubset_prok synonym: "amino acid derivative metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative metabolism" EXACT [] synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah] synonym: "modified amino acid metabolic process" EXACT [GOC:mah] synonym: "modified amino acid metabolism" EXACT [GOC:mah] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0006576 name: cellular biogenic amine metabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] subset: gosubset_prok synonym: "biogenic amine metabolism" EXACT [] is_a: GO:0044106 ! cellular amine metabolic process [Term] id: GO:0006577 name: betaine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "betaine metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0006578 name: betaine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "betaine anabolism" EXACT [] synonym: "betaine biosynthesis" EXACT [] synonym: "betaine formation" EXACT [] synonym: "betaine synthesis" EXACT [] is_a: GO:0006577 ! betaine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0006579 name: betaine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "betaine breakdown" EXACT [] synonym: "betaine catabolism" EXACT [] synonym: "betaine degradation" EXACT [] is_a: GO:0006577 ! betaine metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0006580 name: ethanolamine metabolic process namespace: biological_process alt_id: GO:0006645 def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [CHEBI:16000, GOC:jl, ISBN:01928006X] subset: gosubset_prok synonym: "ethanolamine metabolism" EXACT [] is_a: GO:0042439 ! ethanolamine-containing compound metabolic process [Term] id: GO:0006581 name: acetylcholine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine breakdown" EXACT [] synonym: "acetylcholine catabolism" EXACT [] synonym: "acetylcholine degradation" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] id: GO:0006582 name: melanin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:go_curators] subset: gosubset_prok synonym: "melanin metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0006583 name: melanin biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] subset: gosubset_prok synonym: "melanin anabolism from tyrosine" EXACT [] synonym: "melanin formation from tyrosine" EXACT [] synonym: "melanin synthesis from tyrosine" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0042438 ! melanin biosynthetic process [Term] id: GO:0006584 name: catecholamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "catecholamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0009712 ! catechol metabolic process [Term] id: GO:0006585 name: dopamine biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "dopamine anabolism from tyrosine" EXACT [] synonym: "dopamine formation from tyrosine" EXACT [] synonym: "dopamine synthesis from tyrosine" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0042416 ! dopamine biosynthetic process [Term] id: GO:0006586 name: indolalkylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [CHEBI:38631, GOC:curators] subset: gosubset_prok synonym: "indolalkylamine metabolism" EXACT [] synonym: "indolamine metabolic process" BROAD [] synonym: "indolamine metabolism" BROAD [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0006587 name: serotonin biosynthetic process from tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "serotonin anabolism from tryptophan" EXACT [] synonym: "serotonin formation from tryptophan" EXACT [] synonym: "serotonin synthesis from tryptophan" EXACT [] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0042427 ! serotonin biosynthetic process [Term] id: GO:0006588 name: activation of tryptophan 5-monooxygenase activity namespace: biological_process def: "The process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity." [GOC:dph, GOC:tb] synonym: "tryptophan hydroxylase activation" RELATED [GOC:dph, GOC:tb] is_a: GO:0032770 ! positive regulation of monooxygenase activity relationship: part_of GO:0006587 ! serotonin biosynthetic process from tryptophan [Term] id: GO:0006589 name: octopamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "octopamine anabolism" EXACT [] synonym: "octopamine biosynthesis" EXACT [] synonym: "octopamine formation" EXACT [] synonym: "octopamine synthesis" EXACT [] is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0046333 ! octopamine metabolic process [Term] id: GO:0006590 name: thyroid hormone generation namespace: biological_process def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094] comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. is_a: GO:0042403 ! thyroid hormone metabolic process [Term] id: GO:0006591 name: ornithine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "ornithine metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0006592 name: ornithine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "ornithine anabolism" EXACT [] synonym: "ornithine biosynthesis" EXACT [] synonym: "ornithine formation" EXACT [] synonym: "ornithine synthesis" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0008652 ! cellular amino acid biosynthetic process [Term] id: GO:0006593 name: ornithine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "ornithine breakdown" EXACT [] synonym: "ornithine catabolism" EXACT [] synonym: "ornithine degradation" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0009063 ! cellular amino acid catabolic process [Term] id: GO:0006595 name: polyamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyamine metabolism" EXACT [] xref: Reactome:1252941 "Metabolism of polyamines" xref: Reactome:1279875 "Metabolism of polyamines" xref: Reactome:1299074 "Metabolism of polyamines" xref: Reactome:1326444 "Metabolism of polyamines" xref: Reactome:1352560 "Metabolism of polyamines" xref: Reactome:1372787 "Metabolism of polyamines" xref: Reactome:1392797 "Metabolism of polyamines" xref: Reactome:1417274 "Metabolism of polyamines" xref: Reactome:1450363 "Metabolism of polyamines" xref: Reactome:1471384 "Metabolism of polyamines" xref: Reactome:1483340 "Metabolism of polyamines" xref: Reactome:1496865 "Metabolism of polyamines" xref: Reactome:1514258 "Metabolism of polyamines" xref: Reactome:1520935 "Metabolism of polyamines" xref: Reactome:1526689 "Metabolism of polyamines" xref: Reactome:1532418 "Metabolism of polyamines" xref: Reactome:1536116 "Metabolism of polyamines" xref: Reactome:1538076 "Metabolism of polyamines" xref: Reactome:1539350 "Metabolism of polyamines" xref: Reactome:1540359 "Metabolism of polyamines" xref: Reactome:351202 "Metabolism of polyamines" is_a: GO:0006576 ! cellular biogenic amine metabolic process [Term] id: GO:0006596 name: polyamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyamine anabolism" EXACT [] synonym: "polyamine biosynthesis" EXACT [] synonym: "polyamine formation" EXACT [] synonym: "polyamine synthesis" EXACT [] xref: MetaCyc:POLYAMSYN-PWY xref: Reactome:1253265 "Interconversion of polyamines" xref: Reactome:1280203 "Interconversion of polyamines" xref: Reactome:1299073 "Interconversion of polyamines" xref: Reactome:1326777 "Interconversion of polyamines" xref: Reactome:1352881 "Interconversion of polyamines" xref: Reactome:1373087 "Interconversion of polyamines" xref: Reactome:1393102 "Interconversion of polyamines" xref: Reactome:1417588 "Interconversion of polyamines" xref: Reactome:1450679 "Interconversion of polyamines" xref: Reactome:1471383 "Interconversion of polyamines" xref: Reactome:1483339 "Interconversion of polyamines" xref: Reactome:1496864 "Interconversion of polyamines" xref: Reactome:1514257 "Interconversion of polyamines" xref: Reactome:1521275 "Interconversion of polyamines" xref: Reactome:1526872 "Interconversion of polyamines" xref: Reactome:1532717 "Interconversion of polyamines" xref: Reactome:1539349 "Interconversion of polyamines" xref: Reactome:351200 "Interconversion of polyamines" is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0006597 name: spermine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [CHEBI:15746, GOC:curators] subset: gosubset_prok synonym: "spermine anabolism" EXACT [] synonym: "spermine biosynthesis" EXACT [] synonym: "spermine formation" EXACT [] synonym: "spermine synthesis" EXACT [] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0008215 ! spermine metabolic process [Term] id: GO:0006598 name: polyamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyamine breakdown" EXACT [] synonym: "polyamine catabolism" EXACT [] synonym: "polyamine degradation" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] id: GO:0006599 name: phosphagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphagen metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0006600 name: creatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "creatine metabolism" EXACT [] xref: Reactome:1252957 "Creatine metabolism" xref: Reactome:1279887 "Creatine metabolism" xref: Reactome:1298799 "Creatine metabolism" xref: Reactome:1326460 "Creatine metabolism" xref: Reactome:1352576 "Creatine metabolism" xref: Reactome:1372803 "Creatine metabolism" xref: Reactome:1392813 "Creatine metabolism" xref: Reactome:1417286 "Creatine metabolism" xref: Reactome:1450379 "Creatine metabolism" xref: Reactome:71288 "Creatine metabolism" is_a: GO:0006599 ! phosphagen metabolic process [Term] id: GO:0006601 name: creatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [CHEBI:16919, GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158] subset: gosubset_prok synonym: "creatine anabolism" EXACT [] synonym: "creatine biosynthesis" EXACT [] synonym: "creatine formation" EXACT [] synonym: "creatine synthesis" EXACT [] is_a: GO:0006600 ! creatine metabolic process is_a: GO:0042396 ! phosphagen biosynthetic process [Term] id: GO:0006602 name: creatinine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "creatinine breakdown" EXACT [] synonym: "creatinine catabolism" EXACT [] synonym: "creatinine degradation" EXACT [] is_a: GO:0042397 ! phosphagen catabolic process is_a: GO:0046449 ! creatinine metabolic process is_a: GO:0072340 ! cellular lactam catabolic process [Term] id: GO:0006603 name: phosphocreatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle." [CHEBI:17287, GOC:curators, PMID:16371597] subset: gosubset_prok synonym: "phosphocreatine metabolism" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process [Term] id: GO:0006604 name: phosphoarginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates." [GOC:curators, PMID:16371597] subset: gosubset_prok synonym: "phosphoarginine metabolism" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process [Term] id: GO:0006605 name: protein targeting namespace: biological_process def: "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] subset: goslim_generic subset: goslim_pombe subset: gosubset_prok synonym: "nascent polypeptide association" RELATED [] synonym: "protein sorting along secretory pathway" NARROW [] xref: Wikipedia:Protein_targeting is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0006606 name: protein import into nucleus namespace: biological_process def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah] synonym: "protein import into cell nucleus" EXACT [] synonym: "protein nucleus import" EXACT [] synonym: "protein targeting to nucleus" EXACT [GOC:mah] synonym: "protein transport from cytoplasm to nucleus" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0017038 ! protein import is_a: GO:0051170 ! nuclear import relationship: part_of GO:0034504 ! protein localization to nucleus [Term] id: GO:0006607 name: NLS-bearing substrate import into nucleus namespace: biological_process def: "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] synonym: "NLS-bearing substrate import into cell nucleus" EXACT [] synonym: "NLS-bearing substrate transport from cytoplasm to nucleus" EXACT [] synonym: "NLS-bearing substrate-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006608 name: snRNP protein import into nucleus namespace: biological_process def: "The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] synonym: "snRNP protein import into cell nucleus" EXACT [] synonym: "snRNP protein transport from cytoplasm to nucleus" EXACT [] synonym: "snRNP protein-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006609 name: mRNA-binding (hnRNP) protein import into nucleus namespace: biological_process def: "The directed movement of a heterogeneous nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] synonym: "mRNA-binding (hnRNP) protein import into cell nucleus" EXACT [] synonym: "mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus" EXACT [] synonym: "mRNA-binding (hnRNP) protein-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006610 name: ribosomal protein import into nucleus namespace: biological_process def: "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] synonym: "ribosomal protein import into cell nucleus" EXACT [] synonym: "ribosomal protein transport from cytoplasm to nucleus" EXACT [] synonym: "ribosomal protein-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006611 name: protein export from nucleus namespace: biological_process def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] synonym: "protein export from cell nucleus" EXACT [] synonym: "protein export out of nucleus" EXACT [] synonym: "protein transport from nucleus to cytoplasm" EXACT [] synonym: "protein-nucleus export" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0051168 ! nuclear export [Term] id: GO:0006612 name: protein targeting to membrane namespace: biological_process def: "The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators] synonym: "protein membrane targeting" EXACT [] synonym: "protein-membrane targeting" EXACT [] is_a: GO:0006605 ! protein targeting [Term] id: GO:0006613 name: cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215] synonym: "cotranslational membrane targeting" EXACT [] synonym: "cotranslational protein membrane targeting" EXACT [] synonym: "cotranslational protein-membrane targeting" EXACT [] is_a: GO:0006612 ! protein targeting to membrane [Term] id: GO:0006614 name: SRP-dependent cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] synonym: "ER translocation" BROAD [] synonym: "SRP-dependent cotranslational membrane targeting" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT [] is_a: GO:0006613 ! cotranslational protein targeting to membrane is_a: GO:0045047 ! protein targeting to ER [Term] id: GO:0006615 name: SRP-dependent cotranslational protein targeting to membrane, docking namespace: biological_process def: "The process in which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting." [ISBN:0815316194] synonym: "protein docking during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, docking" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, docking" EXACT [] is_a: GO:0022615 ! protein to membrane docking relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006616 name: SRP-dependent cotranslational protein targeting to membrane, translocation namespace: biological_process def: "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363] synonym: "ER translocation" BROAD [] synonym: "SRP-dependent cotranslational membrane targeting, translocation" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, translocation" EXACT [] synonym: "translocation during SRP-dependent cotranslational protein targeting to membrane" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006617 name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition namespace: biological_process def: "The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting." [ISBN:0815316194] synonym: "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, signal sequence recognition" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006618 name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing namespace: biological_process def: "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting." [ISBN:0815316194] synonym: "signal sequence processing during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, signal sequence processing" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing" EXACT [] is_a: GO:0006465 ! signal peptide processing relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006619 name: SRP-independent cotranslational protein-membrane targeting namespace: biological_process def: "OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition." [GOC:ai, PMID:11101515] comment: This term was made obsolete because there is no evidence for the existence of this process. synonym: "ER translocation" BROAD [] synonym: "SRP-independent cotranslational membrane targeting" EXACT [] is_obsolete: true [Term] id: GO:0006620 name: posttranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane." [ISBN:0716731363] synonym: "posttranslational membrane targeting" EXACT [] synonym: "posttranslational protein membrane targeting" EXACT [] synonym: "posttranslational protein-membrane targeting" EXACT [] synonym: "SRP-independent protein-membrane targeting" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0045047 ! protein targeting to ER [Term] id: GO:0006621 name: protein retention in ER lumen namespace: biological_process def: "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550] synonym: "maintenance of protein location in ER lumen" BROAD [GOC:dph, GOC:tb] is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum [Term] id: GO:0006622 name: protein targeting to lysosome namespace: biological_process def: "The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators] synonym: "protein-lysosome targeting" EXACT [] is_a: GO:0006623 ! protein targeting to vacuole is_a: GO:0007041 ! lysosomal transport [Term] id: GO:0006623 name: protein targeting to vacuole namespace: biological_process def: "The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators] synonym: "protein vacuolar targeting" EXACT [] synonym: "protein-vacuolar targeting" EXACT [] synonym: "protein-vacuole targeting" EXACT [] synonym: "vacuolar protein sorting" EXACT [GOC:vw] is_a: GO:0006605 ! protein targeting is_a: GO:0007034 ! vacuolar transport is_a: GO:0072666 ! establishment of protein localization to vacuole [Term] id: GO:0006624 name: vacuolar protein processing namespace: biological_process def: "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes." [GOC:mah] synonym: "vacuolar protein maturation" RELATED [] synonym: "vacuolar proteolysis" RELATED [] is_a: GO:0016485 ! protein processing is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006625 name: protein targeting to peroxisome namespace: biological_process def: "The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai] synonym: "protein-peroxisome targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0043574 ! peroxisomal transport is_a: GO:0072663 ! establishment of protein localization to peroxisome [Term] id: GO:0006626 name: protein targeting to mitochondrion namespace: biological_process alt_id: GO:0043681 def: "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363] synonym: "mitochondrial protein import" RELATED [] synonym: "mitochondrial translocation" RELATED [] synonym: "protein import into mitochondrion" EXACT [] synonym: "protein targeting to mitochondria" EXACT [] synonym: "protein-mitochondrial targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0006839 ! mitochondrial transport is_a: GO:0017038 ! protein import is_a: GO:0072655 ! establishment of protein localization in mitochondrion relationship: part_of GO:0007005 ! mitochondrion organization [Term] id: GO:0006627 name: protein processing involved in protein targeting to mitochondrion namespace: biological_process def: "The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769] synonym: "mitochondrial processing" BROAD [] synonym: "mitochondrial protein processing during import" RELATED [GOC:dph, GOC:tb] is_a: GO:0034982 ! mitochondrial protein processing relationship: part_of GO:0006626 ! protein targeting to mitochondrion [Term] id: GO:0006628 name: mitochondrial translocation namespace: biological_process def: "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery." [PMID:7600576] comment: This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation. is_obsolete: true consider: GO:0006626 [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: gosubset_prok synonym: "lipid metabolism" EXACT [] xref: Reactome:1253333 "Lipid digestion, mobilization, and transport" xref: Reactome:1280271 "Lipid digestion, mobilization, and transport" xref: Reactome:1299128 "Lipid digestion, mobilization, and transport" xref: Reactome:1326849 "Lipid digestion, mobilization, and transport" xref: Reactome:1352942 "Lipid digestion, mobilization, and transport" xref: Reactome:1373148 "Lipid digestion, mobilization, and transport" xref: Reactome:1393164 "Lipid digestion, mobilization, and transport" xref: Reactome:1417650 "Lipid digestion, mobilization, and transport" xref: Reactome:1450751 "Lipid digestion, mobilization, and transport" xref: Reactome:1471191 "Lipid digestion, mobilization, and transport" xref: Reactome:1483184 "Lipid digestion, mobilization, and transport" xref: Reactome:1497014 "Lipid digestion, mobilization, and transport" xref: Reactome:1514401 "Lipid digestion, mobilization, and transport" xref: Reactome:1521136 "Lipid digestion, mobilization, and transport" xref: Reactome:1526894 "Lipid digestion, mobilization, and transport" xref: Reactome:1532623 "Lipid digestion, mobilization, and transport" xref: Reactome:1536114 "Lipid digestion, mobilization, and transport" xref: Reactome:1538037 "Lipid digestion, mobilization, and transport" xref: Reactome:1539320 "Lipid digestion, mobilization, and transport" xref: Reactome:73923 "Lipid digestion, mobilization, and transport" xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process [Term] id: GO:0006630 name: lipid binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0008289 [Term] id: GO:0006631 name: fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] subset: gosubset_prok synonym: "fatty acid metabolism" EXACT [] xref: Reactome:1230010 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:1257784 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:1283411 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:1303842 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:1356225 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:1397457 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:1423462 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:76466 "CYP4A11 omega-hydroxylates laurate" xref: Wikipedia:Fatty_acid_metabolism is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006633 name: fatty acid biosynthetic process namespace: biological_process alt_id: GO:0000037 def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fatty acid anabolism" EXACT [] synonym: "fatty acid biosynthesis" EXACT [] synonym: "fatty acid formation" EXACT [] synonym: "fatty acid synthesis" EXACT [] xref: MetaCyc:FASYN-INITIAL-PWY xref: MetaCyc:PWY-4381 xref: MetaCyc:PWY-5156 xref: Wikipedia:Fatty_acid_synthesis is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0006634 name: hexadecanal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/] subset: gosubset_prok synonym: "hexadecanal anabolism" EXACT [] synonym: "hexadecanal biosynthesis" EXACT [] synonym: "hexadecanal formation" EXACT [] synonym: "hexadecanal synthesis" EXACT [] synonym: "palmitaldehyde biosynthesis" EXACT [] synonym: "palmitaldehyde biosynthetic process" EXACT [] is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0046458 ! hexadecanal metabolic process [Term] id: GO:0006635 name: fatty acid beta-oxidation namespace: biological_process def: "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:FAO-PWY] subset: gosubset_prok xref: Reactome:109339 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:109342 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:109343 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:109998 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1230340 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1230346 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1230805 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1252947 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1253113 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1258103 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:1258104 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1258105 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:1258111 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1258598 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1279881 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1280048 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1283640 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:1283641 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1283642 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:1283653 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1298793 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1298934 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1304137 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:1304138 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1304139 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:1304145 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1304530 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1326450 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1326618 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1331615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:1331616 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1331617 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:1331623 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1332161 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1352566 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1352731 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1356466 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:1356467 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:1356473 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1356781 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1372793 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1372942 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1377450 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:1377451 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1377452 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:1377458 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1377781 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1392803 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1392958 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1397740 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:1397741 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1397742 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:1397751 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1398127 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1417280 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1417438 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1423827 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:1423828 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1423829 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:1423835 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1424488 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1450369 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1450531 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1456152 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1456345 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1471019 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1471034 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1474998 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1475014 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1482940 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1483050 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:1496808 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1514198 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1520942 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1537986 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1538576 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:1538577 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:1538578 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:1538584 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:1538587 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:1539237 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:1539278 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:77288 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:77289 "Mitochondrial Fatty Acid Beta-Oxidation" is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0006636 name: unsaturated fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782] subset: gosubset_prok synonym: "fatty acid desaturation" RELATED [] synonym: "unsaturated fatty acid anabolism" EXACT [] synonym: "unsaturated fatty acid biosynthesis" EXACT [] synonym: "unsaturated fatty acid formation" EXACT [] synonym: "unsaturated fatty acid synthesis" EXACT [] xref: MetaCyc:PWY-762 xref: MetaCyc:PWY-782 is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0006637 name: acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acyl-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0035383 ! thioester metabolic process [Term] id: GO:0006638 name: neutral lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684] subset: gosubset_prok synonym: "neutral lipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006639 name: acylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acylglycerol metabolism" EXACT [] synonym: "glyceride metabolic process" EXACT [] synonym: "glyceride metabolism" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0006662 ! glycerol ether metabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0006640 name: monoacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "monoacylglycerol anabolism" EXACT [] synonym: "monoacylglycerol biosynthesis" EXACT [] synonym: "monoacylglycerol formation" EXACT [] synonym: "monoacylglycerol synthesis" EXACT [] synonym: "monoglyceride biosynthesis" EXACT [] synonym: "monoglyceride biosynthetic process" EXACT [] is_a: GO:0046462 ! monoacylglycerol metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0006641 name: triglyceride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "triacylglycerol metabolic process" EXACT [] synonym: "triacylglycerol metabolism" EXACT [] synonym: "triglyceride metabolism" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process [Term] id: GO:0006642 name: triglyceride mobilization namespace: biological_process def: "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625] subset: gosubset_prok synonym: "triacylglycerol mobilization" EXACT [] is_a: GO:0006641 ! triglyceride metabolic process [Term] id: GO:0006643 name: membrane lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] subset: gosubset_prok synonym: "membrane lipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006644 name: phospholipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phospholipid metabolism" EXACT [] is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006646 name: phosphatidylethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylethanolamine anabolism" EXACT [] synonym: "phosphatidylethanolamine biosynthesis" EXACT [] synonym: "phosphatidylethanolamine formation" EXACT [] synonym: "phosphatidylethanolamine synthesis" EXACT [] is_a: GO:0046335 ! ethanolamine biosynthetic process is_a: GO:0046337 ! phosphatidylethanolamine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006647 name: phosphatidyl-N-monomethylethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group." [GOC:ai] subset: gosubset_prok synonym: "phosphatidyl-N-monomethylethanolamine anabolism" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine biosynthesis" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine formation" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine synthesis" EXACT [] synonym: "PMME biosynthesis" EXACT [] synonym: "PMME biosynthetic process" EXACT [] is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process is_a: GO:0046468 ! phosphatidyl-N-monomethylethanolamine metabolic process [Term] id: GO:0006648 name: dihydrosphingosine-1-P pathway namespace: biological_process def: "A phosphatidylethanolamine biosynthetic process that proceeds via the enzymatic action of dihydrosphingosine phosphate lyase." [GOC:mah, PMID:15643073] subset: gosubset_prok is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process [Term] id: GO:0006649 name: phospholipid transfer to membrane namespace: biological_process def: "The transfer of a phospholipid from its site of synthesis to the plasma membrane." [GOC:go_curators] subset: gosubset_prok is_a: GO:0015914 ! phospholipid transport relationship: part_of GO:0016044 ! cellular membrane organization [Term] id: GO:0006650 name: glycerophospholipid metabolic process namespace: biological_process alt_id: GO:0006652 def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alpha-glycerophosphate pathway" RELATED [] synonym: "glycerophospholipid metabolism" EXACT [] synonym: "phosphoglyceride metabolic process" EXACT [] synonym: "phosphoglyceride metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0006651 name: diacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues." [CHEBI:18035, GOC:curators] subset: gosubset_prok synonym: "diacylglycerol anabolism" EXACT [] synonym: "diacylglycerol biosynthesis" EXACT [] synonym: "diacylglycerol formation" EXACT [] synonym: "diacylglycerol synthesis" EXACT [] is_a: GO:0046339 ! diacylglycerol metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0006653 name: 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin." [CHEBI:16110, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "1,2-diacyl-sn-glycero-3-phosphocholine metabolism" EXACT [GOC:mah] synonym: "lecithin metabolic process" BROAD [CHEBI:16110] is_a: GO:0046470 ! phosphatidylcholine metabolic process [Term] id: GO:0006654 name: phosphatidic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidic acid anabolism" EXACT [] synonym: "phosphatidic acid biosynthesis" EXACT [] synonym: "phosphatidic acid formation" EXACT [] synonym: "phosphatidic acid synthesis" EXACT [] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046473 ! phosphatidic acid metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006655 name: phosphatidylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylglycerol anabolism" EXACT [] synonym: "phosphatidylglycerol biosynthesis" EXACT [] synonym: "phosphatidylglycerol formation" EXACT [] synonym: "phosphatidylglycerol synthesis" EXACT [] is_a: GO:0046471 ! phosphatidylglycerol metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006656 name: phosphatidylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylcholine anabolism" EXACT [] synonym: "phosphatidylcholine biosynthesis" EXACT [] synonym: "phosphatidylcholine formation" EXACT [] synonym: "phosphatidylcholine synthesis" EXACT [] is_a: GO:0046470 ! phosphatidylcholine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006657 name: CDP-choline pathway namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309 "Biochemical Pathways", MetaCyc:PWY3O-450] subset: gosubset_prok synonym: "Kennedy pathway" EXACT [MetaCyc:PWY3O-450] synonym: "phosphatidylcholine biosynthesis from choline" EXACT [GOC:mah, MetaCyc:PWY3O-450] xref: MetaCyc:PWY3O-450 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process [Term] id: GO:0006658 name: phosphatidylserine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylserine metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0006659 name: phosphatidylserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylserine anabolism" EXACT [] synonym: "phosphatidylserine biosynthesis" EXACT [] synonym: "phosphatidylserine formation" EXACT [] synonym: "phosphatidylserine synthesis" EXACT [] is_a: GO:0006658 ! phosphatidylserine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006660 name: phosphatidylserine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylserine breakdown" EXACT [] synonym: "phosphatidylserine catabolism" EXACT [] synonym: "phosphatidylserine degradation" EXACT [] is_a: GO:0006658 ! phosphatidylserine metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0006661 name: phosphatidylinositol biosynthetic process namespace: biological_process alt_id: GO:0046489 def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylinositol anabolism" EXACT [] synonym: "phosphatidylinositol biosynthesis" EXACT [] synonym: "phosphatidylinositol formation" EXACT [] synonym: "phosphatidylinositol synthesis" EXACT [] synonym: "phosphoinositide biosynthesis" EXACT [] synonym: "phosphoinositide biosynthetic process" EXACT [] synonym: "PtdIns biosynthesis" EXACT [] synonym: "PtdIns biosynthetic process" EXACT [] is_a: GO:0046474 ! glycerophospholipid biosynthetic process is_a: GO:0046488 ! phosphatidylinositol metabolic process [Term] id: GO:0006662 name: glycerol ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "glycerol ether metabolism" EXACT [] is_a: GO:0018904 ! organic ether metabolic process [Term] id: GO:0006663 name: platelet activating factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] synonym: "PAF biosynthesis" EXACT [] synonym: "PAF biosynthetic process" EXACT [] synonym: "platelet activating factor anabolism" EXACT [] synonym: "platelet activating factor biosynthesis" EXACT [] synonym: "platelet activating factor formation" EXACT [] synonym: "platelet activating factor synthesis" EXACT [] is_a: GO:0046469 ! platelet activating factor metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006664 name: glycolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent." [CHEBI:33563, ISBN:0198547684] subset: gosubset_prok synonym: "glycolipid metabolism" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process [Term] id: GO:0006665 name: sphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingolipid metabolism" EXACT [] xref: Reactome:1253751 "Sphingolipid metabolism" xref: Reactome:1280683 "Sphingolipid metabolism" xref: Reactome:1299508 "Sphingolipid metabolism" xref: Reactome:1327268 "Sphingolipid metabolism" xref: Reactome:1353363 "Sphingolipid metabolism" xref: Reactome:1373536 "Sphingolipid metabolism" xref: Reactome:1393557 "Sphingolipid metabolism" xref: Reactome:1418058 "Sphingolipid metabolism" xref: Reactome:1451148 "Sphingolipid metabolism" xref: Reactome:1471495 "Sphingolipid metabolism" xref: Reactome:1483429 "Sphingolipid metabolism" xref: Reactome:1497076 "Sphingolipid metabolism" xref: Reactome:1514463 "Sphingolipid metabolism" xref: Reactome:1521335 "Sphingolipid metabolism" xref: Reactome:1527033 "Sphingolipid metabolism" xref: Reactome:1532766 "Sphingolipid metabolism" xref: Reactome:1536146 "Sphingolipid metabolism" xref: Reactome:1539386 "Sphingolipid metabolism" xref: Reactome:428157 "Sphingolipid metabolism" is_a: GO:0006643 ! membrane lipid metabolic process [Term] id: GO:0006666 name: 3-keto-sphinganine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine." [GOC:ai] subset: gosubset_prok synonym: "3-keto-dihydrosphingosine metabolic process" EXACT [] synonym: "3-keto-dihydrosphingosine metabolism" EXACT [] synonym: "3-keto-sphinganine metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006667 name: sphinganine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol." [http://www.chem.qmul.ac.uk/iupac/lipid/lip1n2.html#p18] subset: gosubset_prok synonym: "dihydrosphingosine metabolic process" EXACT [] synonym: "dihydrosphingosine metabolism" EXACT [] synonym: "sphinganine metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006668 name: sphinganine-1-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] subset: gosubset_prok synonym: "dihydrosphingosine-1-phosphate metabolic process" EXACT [] synonym: "dihydrosphingosine-1-phosphate metabolism" EXACT [] synonym: "sphinganine-1-phosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006669 name: sphinganine-1-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] subset: gosubset_prok synonym: "dihydrosphingosine-1-phosphate biosynthesis" EXACT [] synonym: "dihydrosphingosine-1-phosphate biosynthetic process" EXACT [] synonym: "sphinganine-1-phosphate anabolism" EXACT [] synonym: "sphinganine-1-phosphate biosynthesis" EXACT [] synonym: "sphinganine-1-phosphate formation" EXACT [] synonym: "sphinganine-1-phosphate synthesis" EXACT [] is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046520 ! sphingoid biosynthetic process [Term] id: GO:0006670 name: sphingosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "(4E)-sphing-4-enine metabolic process" EXACT [] synonym: "(4E)-sphing-4-enine metabolism" EXACT [] synonym: "sphing-4-enine metabolic process" EXACT [] synonym: "sphing-4-enine metabolism" EXACT [] synonym: "sphingosine metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006671 name: phytosphingosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids." [CHEBI:46961, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phytosphingosine metabolism" EXACT [] is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006672 name: ceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684] subset: gosubset_prok synonym: "ceramide metabolism" EXACT [] is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006673 name: inositolphosphoceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositolphosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html] subset: gosubset_prok synonym: "inositolphosphoceramide metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006672 ! ceramide metabolic process [Term] id: GO:0006674 name: inositol phosphorylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositol phosphorylceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group. The phosphate-containing group is the trivalent -P(O)= and the ceramide group of this lipid consists of phytosphingosine and a hydroxy C26 fatty acid." [http://www.cyberlipid.org/] subset: gosubset_prok synonym: "inositol phosphorylceramide metabolism" EXACT [] is_a: GO:0006673 ! inositolphosphoceramide metabolic process [Term] id: GO:0006675 name: mannosyl-inositol phosphorylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai, MetaCyc:MIPC] subset: gosubset_prok synonym: "mannose inositol phosphoceramide metabolic process" EXACT [] synonym: "mannose inositol phosphoceramide metabolism" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) metabolic process" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT [] synonym: "mannosyl-inositol-phosphorylceramide metabolism" EXACT [] synonym: "MIPC metabolic process" EXACT [] synonym: "MIPC metabolism" EXACT [] is_a: GO:0006673 ! inositolphosphoceramide metabolic process [Term] id: GO:0006676 name: mannosyl diphosphorylinositol ceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] subset: gosubset_prok synonym: "M(IP)2C metabolic process" EXACT [] synonym: "M(IP)2C metabolism" EXACT [] synonym: "mannosyl diphosphorylinositol ceramide metabolism" EXACT [] is_a: GO:0006673 ! inositolphosphoceramide metabolic process [Term] id: GO:0006677 name: glycosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycosylceramide metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006672 ! ceramide metabolic process [Term] id: GO:0006678 name: glucosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." [CHEBI:36500, GOC:curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucosylceramide metabolism" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0006679 name: glucosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "glucosylceramide anabolism" EXACT [] synonym: "glucosylceramide biosynthesis" EXACT [] synonym: "glucosylceramide formation" EXACT [] synonym: "glucosylceramide synthesis" EXACT [] is_a: GO:0006678 ! glucosylceramide metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046476 ! glycosylceramide biosynthetic process [Term] id: GO:0006680 name: glucosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "glucosylceramide breakdown" EXACT [] synonym: "glucosylceramide catabolism" EXACT [] synonym: "glucosylceramide degradation" EXACT [] is_a: GO:0006678 ! glucosylceramide metabolic process is_a: GO:0046477 ! glycosylceramide catabolic process is_a: GO:0046479 ! glycosphingolipid catabolic process [Term] id: GO:0006681 name: galactosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "galactosylceramide metabolism" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0019374 ! galactolipid metabolic process [Term] id: GO:0006682 name: galactosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "galactosylceramide anabolism" EXACT [] synonym: "galactosylceramide biosynthesis" EXACT [] synonym: "galactosylceramide formation" EXACT [] synonym: "galactosylceramide synthesis" EXACT [] is_a: GO:0006681 ! galactosylceramide metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0019375 ! galactolipid biosynthetic process is_a: GO:0046476 ! glycosylceramide biosynthetic process [Term] id: GO:0006683 name: galactosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "galactosylceramide breakdown" EXACT [] synonym: "galactosylceramide catabolism" EXACT [] synonym: "galactosylceramide degradation" EXACT [] is_a: GO:0006681 ! galactosylceramide metabolic process is_a: GO:0019376 ! galactolipid catabolic process is_a: GO:0046477 ! glycosylceramide catabolic process is_a: GO:0046479 ! glycosphingolipid catabolic process [Term] id: GO:0006684 name: sphingomyelin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingomyelin metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006685 name: sphingomyelin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingomyelin breakdown" EXACT [] synonym: "sphingomyelin catabolism" EXACT [] synonym: "sphingomyelin degradation" EXACT [] is_a: GO:0006684 ! sphingomyelin metabolic process is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process [Term] id: GO:0006686 name: sphingomyelin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingomyelin anabolism" EXACT [] synonym: "sphingomyelin biosynthesis" EXACT [] synonym: "sphingomyelin formation" EXACT [] synonym: "sphingomyelin synthesis" EXACT [] is_a: GO:0006684 ! sphingomyelin metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0006687 name: glycosphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684] subset: gosubset_prok synonym: "glycosphingolipid metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006688 name: glycosphingolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] subset: gosubset_prok synonym: "glycosphingolipid anabolism" EXACT [] synonym: "glycosphingolipid biosynthesis" EXACT [] synonym: "glycosphingolipid formation" EXACT [] synonym: "glycosphingolipid synthesis" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process [Term] id: GO:0006689 name: ganglioside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues." [ISBN:0198547684] subset: gosubset_prok synonym: "ganglioside breakdown" EXACT [] synonym: "ganglioside catabolism" EXACT [] synonym: "ganglioside degradation" EXACT [] is_a: GO:0001573 ! ganglioside metabolic process is_a: GO:0046479 ! glycosphingolipid catabolic process [Term] id: GO:0006690 name: icosanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma] subset: gosubset_prok synonym: "eicosanoid metabolic process" EXACT [] synonym: "eicosanoid metabolism" EXACT [] synonym: "icosanoid metabolism" EXACT [] is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0006691 name: leukotriene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:ma] subset: gosubset_prok synonym: "leukotriene metabolism" EXACT [] is_a: GO:0006690 ! icosanoid metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0006692 name: prostanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "prostanoid metabolism" EXACT [] xref: Reactome:1253087 "Prostanoid metabolism" xref: Reactome:1280022 "Prostanoid metabolism" xref: Reactome:1298908 "Prostanoid metabolism" xref: Reactome:1326592 "Prostanoid metabolism" xref: Reactome:1352703 "Prostanoid metabolism" xref: Reactome:1372919 "Prostanoid metabolism" xref: Reactome:1392935 "Prostanoid metabolism" xref: Reactome:1417412 "Prostanoid metabolism" xref: Reactome:1450509 "Prostanoid metabolism" xref: Reactome:1471377 "Prostanoid metabolism" xref: Reactome:1483333 "Prostanoid metabolism" xref: Reactome:1497015 "Prostanoid metabolism" xref: Reactome:1514402 "Prostanoid metabolism" xref: Reactome:1521271 "Prostanoid metabolism" xref: Reactome:1526976 "Prostanoid metabolism" xref: Reactome:1532712 "Prostanoid metabolism" xref: Reactome:1536115 "Prostanoid metabolism" xref: Reactome:1538074 "Prostanoid metabolism" xref: Reactome:209962 "Prostanoid metabolism" is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0006693 name: prostaglandin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "prostaglandin metabolism" EXACT [] is_a: GO:0006692 ! prostanoid metabolic process [Term] id: GO:0006694 name: steroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] subset: gosubset_prok synonym: "steroid anabolism" EXACT [] synonym: "steroid biosynthesis" EXACT [] synonym: "steroid formation" EXACT [] synonym: "steroid synthesis" EXACT [] synonym: "steroidogenesis" EXACT [] xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis is_a: GO:0008202 ! steroid metabolic process is_a: GO:0008610 ! lipid biosynthetic process [Term] id: GO:0006695 name: cholesterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] synonym: "cholesterol anabolism" EXACT [] synonym: "cholesterol biosynthesis" EXACT [] synonym: "cholesterol formation" EXACT [] synonym: "cholesterol synthesis" EXACT [] xref: Reactome:1253459 "Cholesterol biosynthesis" xref: Reactome:1280397 "Cholesterol biosynthesis" xref: Reactome:1299234 "Cholesterol biosynthesis" xref: Reactome:1326975 "Cholesterol biosynthesis" xref: Reactome:1353070 "Cholesterol biosynthesis" xref: Reactome:1373260 "Cholesterol biosynthesis" xref: Reactome:1393279 "Cholesterol biosynthesis" xref: Reactome:1417771 "Cholesterol biosynthesis" xref: Reactome:1450871 "Cholesterol biosynthesis" xref: Reactome:1471262 "Cholesterol biosynthesis" xref: Reactome:1483237 "Cholesterol biosynthesis" xref: Reactome:1496923 "Cholesterol biosynthesis" xref: Reactome:1514311 "Cholesterol biosynthesis" xref: Reactome:1521179 "Cholesterol biosynthesis" xref: Reactome:1526919 "Cholesterol biosynthesis" xref: Reactome:1532658 "Cholesterol biosynthesis" xref: Reactome:1536083 "Cholesterol biosynthesis" xref: Reactome:1538049 "Cholesterol biosynthesis" xref: Reactome:1539330 "Cholesterol biosynthesis" xref: Reactome:1540341 "Cholesterol biosynthesis" xref: Reactome:191273 "Cholesterol biosynthesis" is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0016126 ! sterol biosynthetic process [Term] id: GO:0006696 name: ergosterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ergosterol anabolism" EXACT [] synonym: "ergosterol biosynthesis" EXACT [] synonym: "ergosterol formation" EXACT [] synonym: "ergosterol synthesis" EXACT [] is_a: GO:0008204 ! ergosterol metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0016129 ! phytosteroid biosynthetic process is_a: GO:0044108 ! cellular alcohol biosynthetic process [Term] id: GO:0006697 name: ecdysone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ecdysone anabolism" EXACT [] synonym: "ecdysone biosynthesis" EXACT [] synonym: "ecdysone formation" EXACT [] synonym: "ecdysone synthesis" EXACT [] is_a: GO:0008205 ! ecdysone metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0006698 name: ecdysone modification namespace: biological_process def: "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties." [GOC:jl] comment: This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC 1.14.99.22) and so is a function rather than a process. is_obsolete: true replaced_by: GO:0004501 [Term] id: GO:0006699 name: bile acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid anabolism" EXACT [] synonym: "bile acid biosynthesis" EXACT [] synonym: "bile acid formation" EXACT [] synonym: "bile acid synthesis" EXACT [] xref: Reactome:1253463 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1253464 "Synthesis of bile acids and bile salts" xref: Reactome:1253465 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1253467 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1280401 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1280402 "Synthesis of bile acids and bile salts" xref: Reactome:1280403 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1280405 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1299238 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1299239 "Synthesis of bile acids and bile salts" xref: Reactome:1299240 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1299242 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1326979 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1326980 "Synthesis of bile acids and bile salts" xref: Reactome:1326981 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1326983 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1353074 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1353075 "Synthesis of bile acids and bile salts" xref: Reactome:1353076 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1353078 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1373264 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1373265 "Synthesis of bile acids and bile salts" xref: Reactome:1373266 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1373268 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1393283 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1393284 "Synthesis of bile acids and bile salts" xref: Reactome:1393285 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1393287 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1417775 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1417776 "Synthesis of bile acids and bile salts" xref: Reactome:1417777 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1417779 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1450875 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1450876 "Synthesis of bile acids and bile salts" xref: Reactome:1450877 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1450880 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1471266 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1471267 "Synthesis of bile acids and bile salts" xref: Reactome:1471269 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1471272 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1483238 "Synthesis of bile acids and bile salts" xref: Reactome:1483240 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1483241 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1483253 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1496924 "Synthesis of bile acids and bile salts" xref: Reactome:1496926 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1496929 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1514312 "Synthesis of bile acids and bile salts" xref: Reactome:1514314 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1521180 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1521181 "Synthesis of bile acids and bile salts" xref: Reactome:1526920 "Synthesis of bile acids and bile salts" xref: Reactome:1526922 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1526923 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1526934 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1532659 "Synthesis of bile acids and bile salts" xref: Reactome:1532661 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1532670 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1532671 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1538050 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1538051 "Synthesis of bile acids and bile salts" xref: Reactome:1538053 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:1538054 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:1539331 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:1539332 "Synthesis of bile acids and bile salts" xref: Reactome:1539333 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:192105 "Synthesis of bile acids and bile salts" xref: Reactome:193368 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:193775 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:193807 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0006700 name: C21-steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone anabolism" EXACT [] synonym: "C21-steroid hormone biosynthesis" EXACT [] synonym: "C21-steroid hormone formation" EXACT [] synonym: "C21-steroid hormone synthesis" EXACT [] xref: Reactome:1253473 "Pregnenolone biosynthesis" xref: Reactome:1280411 "Pregnenolone biosynthesis" xref: Reactome:1299274 "Pregnenolone biosynthesis" xref: Reactome:1326989 "Pregnenolone biosynthesis" xref: Reactome:1353084 "Pregnenolone biosynthesis" xref: Reactome:1373273 "Pregnenolone biosynthesis" xref: Reactome:1393293 "Pregnenolone biosynthesis" xref: Reactome:1417785 "Pregnenolone biosynthesis" xref: Reactome:1450885 "Pregnenolone biosynthesis" xref: Reactome:1471277 "Pregnenolone biosynthesis" xref: Reactome:1483244 "Pregnenolone biosynthesis" xref: Reactome:1526937 "Pregnenolone biosynthesis" xref: Reactome:1532676 "Pregnenolone biosynthesis" xref: Reactome:1538055 "Pregnenolone biosynthesis" xref: Reactome:196108 "Pregnenolone biosynthesis" is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006701 name: progesterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone anabolism" EXACT [] synonym: "progesterone biosynthesis" EXACT [] synonym: "progesterone formation" EXACT [] synonym: "progesterone synthesis" EXACT [] is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0042448 ! progesterone metabolic process [Term] id: GO:0006702 name: androgen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "androgen anabolism" EXACT [] synonym: "androgen biosynthesis" EXACT [] synonym: "androgen formation" EXACT [] synonym: "androgen synthesis" EXACT [] xref: Reactome:1253475 "Androgen biosynthesis" xref: Reactome:1280413 "Androgen biosynthesis" xref: Reactome:1299247 "Androgen biosynthesis" xref: Reactome:1326991 "Androgen biosynthesis" xref: Reactome:1353086 "Androgen biosynthesis" xref: Reactome:1373275 "Androgen biosynthesis" xref: Reactome:1393295 "Androgen biosynthesis" xref: Reactome:1417787 "Androgen biosynthesis" xref: Reactome:1450887 "Androgen biosynthesis" xref: Reactome:1471278 "Androgen biosynthesis" xref: Reactome:1483248 "Androgen biosynthesis" xref: Reactome:1496930 "Androgen biosynthesis" xref: Reactome:1514315 "Androgen biosynthesis" xref: Reactome:1521183 "Androgen biosynthesis" xref: Reactome:1526926 "Androgen biosynthesis" xref: Reactome:1532662 "Androgen biosynthesis" xref: Reactome:1536084 "Androgen biosynthesis" xref: Reactome:193048 "Androgen biosynthesis" is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008209 ! androgen metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006703 name: estrogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "estrogen anabolism" EXACT [] synonym: "estrogen biosynthesis" EXACT [] synonym: "estrogen formation" EXACT [] synonym: "estrogen synthesis" EXACT [] synonym: "oestrogen biosynthesis" EXACT [] synonym: "oestrogen biosynthetic process" EXACT [] xref: Reactome:1253474 "Estrogen biosynthesis" xref: Reactome:1280412 "Estrogen biosynthesis" xref: Reactome:1326990 "Estrogen biosynthesis" xref: Reactome:1353085 "Estrogen biosynthesis" xref: Reactome:1373274 "Estrogen biosynthesis" xref: Reactome:1393294 "Estrogen biosynthesis" xref: Reactome:1417786 "Estrogen biosynthesis" xref: Reactome:1450886 "Estrogen biosynthesis" xref: Reactome:193144 "Estrogen biosynthesis" xref: Reactome:804969 "Estrone is hydrogenated to estradiol" is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008210 ! estrogen metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006704 name: glucocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "glucocorticoid anabolism" EXACT [] synonym: "glucocorticoid biosynthesis" EXACT [] synonym: "glucocorticoid formation" EXACT [] synonym: "glucocorticoid synthesis" EXACT [] xref: Reactome:1253476 "Glucocorticoid biosynthesis" xref: Reactome:1280414 "Glucocorticoid biosynthesis" xref: Reactome:1299248 "Glucocorticoid biosynthesis" xref: Reactome:1326992 "Glucocorticoid biosynthesis" xref: Reactome:1353087 "Glucocorticoid biosynthesis" xref: Reactome:1373290 "Glucocorticoid biosynthesis" xref: Reactome:1393296 "Glucocorticoid biosynthesis" xref: Reactome:1417788 "Glucocorticoid biosynthesis" xref: Reactome:1450888 "Glucocorticoid biosynthesis" xref: Reactome:1471282 "Glucocorticoid biosynthesis" xref: Reactome:1483255 "Glucocorticoid biosynthesis" xref: Reactome:1496934 "Glucocorticoid biosynthesis" xref: Reactome:1514319 "Glucocorticoid biosynthesis" xref: Reactome:1521187 "Glucocorticoid biosynthesis" xref: Reactome:1539336 "Glucocorticoid biosynthesis" xref: Reactome:194002 "Glucocorticoid biosynthesis" is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0006705 name: mineralocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "mineralocorticoid anabolism" EXACT [] synonym: "mineralocorticoid biosynthesis" EXACT [] synonym: "mineralocorticoid formation" EXACT [] synonym: "mineralocorticoid synthesis" EXACT [] xref: Reactome:1253470 "Mineralocorticoid biosynthesis" xref: Reactome:1280408 "Mineralocorticoid biosynthesis" xref: Reactome:1299244 "Mineralocorticoid biosynthesis" xref: Reactome:1326986 "Mineralocorticoid biosynthesis" xref: Reactome:1353081 "Mineralocorticoid biosynthesis" xref: Reactome:1373270 "Mineralocorticoid biosynthesis" xref: Reactome:1393290 "Mineralocorticoid biosynthesis" xref: Reactome:1417782 "Mineralocorticoid biosynthesis" xref: Reactome:1450882 "Mineralocorticoid biosynthesis" xref: Reactome:1471273 "Mineralocorticoid biosynthesis" xref: Reactome:1483254 "Mineralocorticoid biosynthesis" xref: Reactome:193993 "Mineralocorticoid biosynthesis" is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0008212 ! mineralocorticoid metabolic process [Term] id: GO:0006706 name: steroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] subset: gosubset_prok synonym: "steroid breakdown" EXACT [] synonym: "steroid catabolism" EXACT [] synonym: "steroid degradation" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0016042 ! lipid catabolic process [Term] id: GO:0006707 name: cholesterol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] synonym: "cholesterol breakdown" EXACT [] synonym: "cholesterol catabolism" EXACT [] synonym: "cholesterol degradation" EXACT [] is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0016127 ! sterol catabolic process [Term] id: GO:0006708 name: ecdysone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ecdysone breakdown" EXACT [] synonym: "ecdysone catabolism" EXACT [] synonym: "ecdysone degradation" EXACT [] is_a: GO:0008205 ! ecdysone metabolic process is_a: GO:0016127 ! sterol catabolic process is_a: GO:0046344 ! ecdysteroid catabolic process [Term] id: GO:0006709 name: progesterone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone breakdown" EXACT [] synonym: "progesterone catabolism" EXACT [] synonym: "progesterone degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0042448 ! progesterone metabolic process [Term] id: GO:0006710 name: androgen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "androgen breakdown" EXACT [] synonym: "androgen catabolism" EXACT [] synonym: "androgen degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008209 ! androgen metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006711 name: estrogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "estrogen breakdown" EXACT [] synonym: "estrogen catabolism" EXACT [] synonym: "estrogen degradation" EXACT [] synonym: "oestrogen catabolic process" EXACT [] synonym: "oestrogen catabolism" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008210 ! estrogen metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006712 name: mineralocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "mineralocorticoid breakdown" EXACT [] synonym: "mineralocorticoid catabolism" EXACT [] synonym: "mineralocorticoid degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0008212 ! mineralocorticoid metabolic process [Term] id: GO:0006713 name: glucocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "glucocorticoid breakdown" EXACT [] synonym: "glucocorticoid catabolism" EXACT [] synonym: "glucocorticoid degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0006714 name: sesquiterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684] subset: gosubset_prok synonym: "sesquiterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0051761 ! sesquiterpene metabolic process [Term] id: GO:0006715 name: farnesol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [ISBN:0198547684] subset: gosubset_prok synonym: "farnesol anabolism" EXACT [] synonym: "farnesol biosynthesis" EXACT [] synonym: "farnesol formation" EXACT [] synonym: "farnesol synthesis" EXACT [] is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0016487 ! farnesol metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0006716 name: juvenile hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0006717 name: juvenile hormone binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0005500 [Term] id: GO:0006718 name: juvenile hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone anabolism" EXACT [] synonym: "juvenile hormone biosynthesis" EXACT [] synonym: "juvenile hormone formation" EXACT [] synonym: "juvenile hormone synthesis" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process [Term] id: GO:0006719 name: juvenile hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone breakdown" EXACT [] synonym: "juvenile hormone catabolism" EXACT [] synonym: "juvenile hormone degradation" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006720 name: isoprenoid metabolic process namespace: biological_process alt_id: GO:0016096 def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] subset: gosubset_prok synonym: "isoprenoid metabolism" EXACT [] synonym: "polyisoprenoid metabolic process" NARROW [] synonym: "polyisoprenoid metabolism" NARROW [] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006721 name: terpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "terpenoid metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0006722 name: triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units." [ISBN:0198547684] subset: gosubset_prok synonym: "triterpene metabolic process" NARROW [] synonym: "triterpene metabolism" NARROW [] synonym: "triterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0006723 name: cuticle hydrocarbon biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai] synonym: "cuticle hydrocarbon anabolism" EXACT [] synonym: "cuticle hydrocarbon biosynthesis" EXACT [] synonym: "cuticle hydrocarbon formation" EXACT [] synonym: "cuticle hydrocarbon synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process relationship: part_of GO:0042335 ! cuticle development [Term] id: GO:0006725 name: cellular aromatic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "aromatic compound metabolism" EXACT [] synonym: "aromatic hydrocarbon metabolic process" NARROW [] synonym: "aromatic hydrocarbon metabolism" NARROW [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006726 name: eye pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] synonym: "eye pigment anabolism" EXACT [] synonym: "eye pigment biosynthesis" EXACT [] synonym: "eye pigment formation" EXACT [] synonym: "eye pigment synthesis" EXACT [] is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006727 name: ommochrome biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ommochrome anabolism" EXACT [] synonym: "ommochrome biosynthesis" EXACT [] synonym: "ommochrome formation" EXACT [] synonym: "ommochrome synthesis" EXACT [] is_a: GO:0006726 ! eye pigment biosynthetic process is_a: GO:0008055 ! ocellus pigment biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046152 ! ommochrome metabolic process [Term] id: GO:0006728 name: pteridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pteridine anabolism" EXACT [] synonym: "pteridine biosynthesis" EXACT [] synonym: "pteridine formation" EXACT [] synonym: "pteridine synthesis" EXACT [] synonym: "pterin biosynthesis" NARROW [] synonym: "pterin biosynthetic process" NARROW [] is_a: GO:0019889 ! pteridine metabolic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006729 name: tetrahydrobiopterin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "5,6,7,8-tetrahydrobiopterin biosynthetic process" EXACT [CHEBI:15372, GOC:curators] synonym: "tetrahydrobiopterin anabolism" EXACT [] synonym: "tetrahydrobiopterin biosynthesis" EXACT [] synonym: "tetrahydrobiopterin formation" EXACT [] synonym: "tetrahydrobiopterin synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0046146 ! tetrahydrobiopterin metabolic process [Term] id: GO:0006730 name: one-carbon metabolic process namespace: biological_process alt_id: GO:0019753 alt_id: GO:0019754 def: "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] subset: goslim_pir subset: gosubset_prok synonym: "one carbon metabolic process" EXACT [GOC:mah] synonym: "one carbon metabolism" EXACT [GOC:mah] synonym: "one-carbon metabolism" EXACT [GOC:mah] synonym: "one-carbon transfer metabolic process" EXACT [GOC:mah] synonym: "one-carbon transfer metabolism" EXACT [GOC:mah] xref: UM-BBD_pathwayID:C1cyc is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006731 name: coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. is_obsolete: true consider: GO:0006732 consider: GO:0051189 [Term] id: GO:0006732 name: coenzyme metabolic process namespace: biological_process alt_id: GO:0006752 def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "coenzyme metabolism" EXACT [] synonym: "group transfer coenzyme metabolic process" NARROW [] synonym: "group transfer coenzyme metabolism" NARROW [] is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006733 name: oxidoreduction coenzyme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah] subset: gosubset_prok synonym: "oxidoreduction coenzyme metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0006734 name: NADH metabolic process namespace: biological_process def: "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] subset: gosubset_prok synonym: "NAD (reduced) metabolic process" EXACT [] synonym: "NAD (reduced) metabolism" EXACT [] synonym: "NADH metabolism" EXACT [] synonym: "reduced NAD metabolic process" EXACT [] synonym: "reduced NAD metabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide metabolism" EXACT [] is_a: GO:0019674 ! NAD metabolic process [Term] id: GO:0006735 name: NADH regeneration namespace: biological_process def: "A metabolic process that generates a pool of NADH by the reduction of NAD+." [GOC:mah] subset: gosubset_prok synonym: "NAD (reduced) regeneration" EXACT [] synonym: "reduced NAD regeneration" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT [] is_a: GO:0006734 ! NADH metabolic process [Term] id: GO:0006738 name: nicotinamide riboside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-ribosylnicotinamide catabolic process" EXACT [CHEBI:15927] synonym: "nicotinamide riboside breakdown" EXACT [] synonym: "nicotinamide riboside catabolism" EXACT [] synonym: "nicotinamide riboside degradation" EXACT [] is_a: GO:0046495 ! nicotinamide riboside metabolic process is_a: GO:0070638 ! pyridine nucleoside catabolic process [Term] id: GO:0006739 name: NADP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] subset: gosubset_prok synonym: "NAD phosphorylation and dephosphorylation" RELATED [] synonym: "NADP (oxidized) metabolic process" EXACT [] synonym: "NADP (oxidized) metabolism" EXACT [] synonym: "NADP (reduced) metabolic process" EXACT [] synonym: "NADP (reduced) metabolism" EXACT [] synonym: "NADP metabolism" EXACT [] synonym: "NADPH metabolic process" EXACT [] synonym: "NADPH metabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] synonym: "oxidized NADP metabolic process" EXACT [] synonym: "oxidized NADP metabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] synonym: "reduced NADP metabolic process" EXACT [] synonym: "reduced NADP metabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0006740 name: NADPH regeneration namespace: biological_process def: "A metabolic process that generates a pool of NADPH by the reduction of NADP+." [GOC:mah] subset: gosubset_prok synonym: "NADP (reduced) regeneration" EXACT [] synonym: "reduced NADP regeneration" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT [] xref: Reactome:1253672 "NADPH regeneration" xref: Reactome:1280604 "NADPH regeneration" xref: Reactome:1327189 "NADPH regeneration" xref: Reactome:1353284 "NADPH regeneration" xref: Reactome:1373461 "NADPH regeneration" xref: Reactome:1393482 "NADPH regeneration" xref: Reactome:1417982 "NADPH regeneration" xref: Reactome:1451066 "NADPH regeneration" xref: Reactome:1471426 "NADPH regeneration" xref: Reactome:1483377 "NADPH regeneration" xref: Reactome:1521292 "NADPH regeneration" xref: Reactome:1526997 "NADPH regeneration" xref: Reactome:1532735 "NADPH regeneration" xref: Reactome:1539360 "NADPH regeneration" xref: Reactome:389542 "NADPH regeneration" is_a: GO:0006739 ! NADP metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006741 name: NADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] subset: gosubset_prok synonym: "NADP (oxidized) biosynthesis" EXACT [] synonym: "NADP (oxidized) biosynthetic process" EXACT [] synonym: "NADP (reduced) biosynthesis" EXACT [] synonym: "NADP (reduced) biosynthetic process" EXACT [] synonym: "NADP anabolism" EXACT [] synonym: "NADP biosynthesis" EXACT [] synonym: "NADP formation" EXACT [] synonym: "NADP synthesis" EXACT [] synonym: "NADPH biosynthesis" EXACT [] synonym: "NADPH biosynthetic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] synonym: "oxidized NADP biosynthesis" EXACT [] synonym: "oxidized NADP biosynthetic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] synonym: "reduced NADP biosynthesis" EXACT [] synonym: "reduced NADP biosynthetic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0006742 name: NADP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] subset: gosubset_prok synonym: "NADP (oxidized) catabolic process" EXACT [] synonym: "NADP (oxidized) catabolism" EXACT [] synonym: "NADP (reduced) catabolic process" EXACT [] synonym: "NADP (reduced) catabolism" EXACT [] synonym: "NADP breakdown" EXACT [] synonym: "NADP catabolism" EXACT [] synonym: "NADP degradation" EXACT [] synonym: "NADPH catabolic process" EXACT [] synonym: "NADPH catabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] synonym: "oxidized NADP catabolic process" EXACT [] synonym: "oxidized NADP catabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] synonym: "reduced NADP catabolic process" EXACT [] synonym: "reduced NADP catabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0019364 ! pyridine nucleotide catabolic process [Term] id: GO:0006743 name: ubiquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] subset: gosubset_prok synonym: "coenzyme Q metabolic process" EXACT [] synonym: "coenzyme Q metabolism" EXACT [] synonym: "coenzyme Q6 metabolic process" NARROW [] synonym: "coenzyme Q6 metabolism" NARROW [] synonym: "ubiquinone metabolism" EXACT [] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042375 ! quinone cofactor metabolic process [Term] id: GO:0006744 name: ubiquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] subset: gosubset_prok synonym: "coenzyme Q biosynthesis" EXACT [] synonym: "coenzyme Q biosynthetic process" EXACT [] synonym: "coenzyme Q10 biosynthesis" NARROW [] synonym: "coenzyme Q10 biosynthetic process" NARROW [] synonym: "coenzyme Q6 biosynthesis" NARROW [] synonym: "coenzyme Q6 biosynthetic process" NARROW [] synonym: "coenzyme Q8 biosynthesis" NARROW [] synonym: "coenzyme Q8 biosynthetic process" NARROW [] synonym: "coenzyme Q9 biosynthesis" NARROW [] synonym: "coenzyme Q9 biosynthetic process" NARROW [] synonym: "ubiquinone anabolism" EXACT [] synonym: "ubiquinone biosynthesis" EXACT [] synonym: "ubiquinone formation" EXACT [] synonym: "ubiquinone synthesis" EXACT [] xref: MetaCyc:UBISYN-PWY is_a: GO:0006743 ! ubiquinone metabolic process is_a: GO:0045426 ! quinone cofactor biosynthetic process [Term] id: GO:0006746 name: FADH2 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide." [CHEBI:17877, GOC:ai] subset: gosubset_prok synonym: "FADH2 metabolism" EXACT [] synonym: "reduced flavin adenine dinucleotide metabolic process" EXACT [GOC:mah] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process [Term] id: GO:0006747 name: FAD biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide." [CHEBI:16238, GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "FAD anabolism" EXACT [] synonym: "FAD biosynthesis" EXACT [] synonym: "FAD formation" EXACT [] synonym: "FAD synthesis" EXACT [] synonym: "oxidized flavin adenine dinucleotide biosynthesis" EXACT [GOC:curators] synonym: "oxidized flavin adenine dinucleotide biosynthetic process" EXACT [GOC:curators] synonym: "oxidized flavin-adenine dinucleotide biosynthesis" EXACT [GOC:curators] synonym: "oxidized flavin-adenine dinucleotide biosynthetic process" EXACT [GOC:curators] is_a: GO:0046443 ! FAD metabolic process is_a: GO:0072388 ! flavin adenine dinucleotide biosynthetic process [Term] id: GO:0006748 name: lipoamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [CHEBI:17460, GOC:go_curators] subset: gosubset_prok synonym: "lipoamide metabolism" EXACT [] is_a: GO:0009106 ! lipoate metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006749 name: glutathione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glutathione metabolism" EXACT [] synonym: "oxidized glutathione reduction" NARROW [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0006750 name: glutathione biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glutathione anabolism" EXACT [] synonym: "glutathione biosynthesis" EXACT [] synonym: "glutathione formation" EXACT [] synonym: "glutathione synthesis" EXACT [] xref: MetaCyc:GLUTATHIONESYN-PWY xref: Reactome:1253402 "Glutathione synthesis" xref: Reactome:1280343 "Glutathione synthesis" xref: Reactome:1299180 "Glutathione synthesis" xref: Reactome:1326919 "Glutathione synthesis" xref: Reactome:1353010 "Glutathione synthesis" xref: Reactome:1373206 "Glutathione synthesis" xref: Reactome:1393220 "Glutathione synthesis" xref: Reactome:1417716 "Glutathione synthesis" xref: Reactome:1450815 "Glutathione synthesis" xref: Reactome:1471225 "Glutathione synthesis" xref: Reactome:1483214 "Glutathione synthesis" xref: Reactome:1496912 "Glutathione synthesis" xref: Reactome:1514301 "Glutathione synthesis" xref: Reactome:1521167 "Glutathione synthesis" xref: Reactome:1526911 "Glutathione synthesis" xref: Reactome:1532643 "Glutathione synthesis" xref: Reactome:1536073 "Glutathione synthesis" xref: Reactome:174403 "Glutathione synthesis" is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0006751 name: glutathione catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glutathione breakdown" EXACT [] synonym: "glutathione catabolism" EXACT [] synonym: "glutathione degradation" EXACT [] is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0006753 name: nucleoside phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] subset: gosubset_prok synonym: "nucleoside phosphate metabolism" EXACT [] is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process [Term] id: GO:0006754 name: ATP biosynthetic process namespace: biological_process alt_id: GO:0006758 alt_id: GO:0006759 def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ATP anabolism" EXACT [] synonym: "ATP biosynthesis" EXACT [] synonym: "ATP formation" EXACT [] synonym: "ATP regeneration" NARROW [] synonym: "ATP synthesis" EXACT [] xref: Reactome:1233685 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:1233688 "ADP and Pi bind to ATPase" xref: Reactome:1261391 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:1261394 "ADP and Pi bind to ATPase" xref: Reactome:1286274 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:1286277 "ADP and Pi bind to ATPase" xref: Reactome:1307336 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:1307339 "ADP and Pi bind to ATPase" xref: Reactome:1334721 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:1334724 "ADP and Pi bind to ATPase" xref: Reactome:1359062 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:1359065 "ADP and Pi bind to ATPase" xref: Reactome:1379970 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:1379973 "ADP and Pi bind to ATPase" xref: Reactome:1428297 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:1428300 "ADP and Pi bind to ATPase" xref: Reactome:164832 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:164840 "ADP and Pi bind to ATPase" is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006755 name: carbamoyl phosphate-ADP transphosphorylation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because, according to PUMA2, this "pathway" is a single reaction, corresponding to 'carbamate kinase activity ; GO:0008804' (EC:2.7.2.2). is_obsolete: true [Term] id: GO:0006756 name: AMP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP." [GOC:ai] subset: gosubset_prok is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0046033 ! AMP metabolic process is_a: GO:0046940 ! nucleoside monophosphate phosphorylation [Term] id: GO:0006757 name: ADP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006760 name: folic acid-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [CHEBI:37445, GOC:ai, GOC:mah] subset: gosubset_prok synonym: "folate and derivative metabolic process" EXACT [] synonym: "folate and derivative metabolism" EXACT [] synonym: "folate-containing compound metabolic process" EXACT [GOC:curators] synonym: "folate-containing compound metabolism" EXACT [GOC:curators] synonym: "folic acid and derivative metabolic process" EXACT [GOC:curators] synonym: "folic acid and derivative metabolism" EXACT [GOC:curators] synonym: "folic acid-containing compound metabolism" EXACT [GOC:curators] synonym: "vitamin B9 and derivative metabolic process" EXACT [] synonym: "vitamin B9 and derivative metabolism" EXACT [] synonym: "vitamin M and derivative metabolic process" EXACT [] synonym: "vitamin M and derivative metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0006761 name: dihydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate." [GOC:ai] subset: gosubset_prok synonym: "7,8-dihydrofolate biosynthesis" EXACT [] synonym: "7,8-dihydrofolate biosynthetic process" EXACT [] synonym: "dihydrofolate anabolism" EXACT [] synonym: "dihydrofolate biosynthesis" EXACT [] synonym: "dihydrofolate formation" EXACT [] synonym: "dihydrofolate synthesis" EXACT [] is_a: GO:0009396 ! folic acid-containing compound biosynthetic process is_a: GO:0046452 ! dihydrofolate metabolic process [Term] id: GO:0006762 name: dihydrofolate reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004146 consider: GO:0046452 [Term] id: GO:0006766 name: vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "vitamin metabolism" EXACT [] xref: Reactome:1253505 "Metabolism of vitamins and cofactors" xref: Reactome:1280444 "Metabolism of vitamins and cofactors" xref: Reactome:1299278 "Metabolism of vitamins and cofactors" xref: Reactome:1327022 "Metabolism of vitamins and cofactors" xref: Reactome:1353116 "Metabolism of vitamins and cofactors" xref: Reactome:1373305 "Metabolism of vitamins and cofactors" xref: Reactome:1393318 "Metabolism of vitamins and cofactors" xref: Reactome:1417816 "Metabolism of vitamins and cofactors" xref: Reactome:1450914 "Metabolism of vitamins and cofactors" xref: Reactome:1471294 "Metabolism of vitamins and cofactors" xref: Reactome:1483267 "Metabolism of vitamins and cofactors" xref: Reactome:1496939 "Metabolism of vitamins and cofactors" xref: Reactome:1514326 "Metabolism of vitamins and cofactors" xref: Reactome:1521195 "Metabolism of vitamins and cofactors" xref: Reactome:1526941 "Metabolism of vitamins and cofactors" xref: Reactome:1532680 "Metabolism of vitamins and cofactors" xref: Reactome:1536091 "Metabolism of vitamins and cofactors" xref: Reactome:1538062 "Metabolism of vitamins and cofactors" xref: Reactome:1539343 "Metabolism of vitamins and cofactors" xref: Reactome:1540345 "Metabolism of vitamins and cofactors" xref: Reactome:196854 "Metabolism of vitamins and cofactors" is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006767 name: water-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl] subset: gosubset_prok synonym: "water-soluble vitamin metabolism" EXACT [] xref: Reactome:1253504 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1280443 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1299277 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1327021 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1353115 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1373304 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1393317 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1417815 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1450913 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1471293 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1483266 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1496938 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1514325 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1521194 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1526940 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1532679 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1536090 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1538061 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1539342 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:1540344 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:196849 "Metabolism of water-soluble vitamins and cofactors" is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006768 name: biotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "biotin metabolism" EXACT [] synonym: "vitamin B7 metabolic process" EXACT [] synonym: "vitamin B7 metabolism" EXACT [] synonym: "vitamin H metabolic process" EXACT [] synonym: "vitamin H metabolism" EXACT [] xref: Reactome:1253526 "Biotin metabolism" xref: Reactome:1280465 "Biotin metabolism" xref: Reactome:1299290 "Biotin metabolism" xref: Reactome:1327043 "Biotin metabolism" xref: Reactome:1353137 "Biotin metabolism" xref: Reactome:1393338 "Biotin metabolism" xref: Reactome:1417835 "Biotin metabolism" xref: Reactome:1450927 "Biotin metabolism" xref: Reactome:1540349 "Biotin metabolism" xref: Reactome:196780 "Biotin metabolism" xref: Wikipedia:Biotin is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006769 name: nicotinamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "niacin metabolic process" RELATED [] synonym: "niacin metabolism" RELATED [] synonym: "nicotinamide metabolism" EXACT [] synonym: "vitamin B3 metabolic process" BROAD [] synonym: "vitamin B3 metabolism" BROAD [] xref: MetaCyc:PWY-5083 xref: Reactome:1253509 "Nicotinamide salvaging" xref: Reactome:1280447 "Nicotinamide salvaging" xref: Reactome:1299282 "Nicotinamide salvaging" xref: Reactome:1327025 "Nicotinamide salvaging" xref: Reactome:1353119 "Nicotinamide salvaging" xref: Reactome:1373308 "Nicotinamide salvaging" xref: Reactome:1393321 "Nicotinamide salvaging" xref: Reactome:1417819 "Nicotinamide salvaging" xref: Reactome:1450917 "Nicotinamide salvaging" xref: Reactome:1471297 "Nicotinamide salvaging" xref: Reactome:1483270 "Nicotinamide salvaging" xref: Reactome:1496943 "Nicotinamide salvaging" xref: Reactome:1514330 "Nicotinamide salvaging" xref: Reactome:1521198 "Nicotinamide salvaging" xref: Reactome:1536094 "Nicotinamide salvaging" xref: Reactome:1538064 "Nicotinamide salvaging" xref: Reactome:1539344 "Nicotinamide salvaging" xref: Reactome:1540346 "Nicotinamide salvaging" xref: Reactome:197264 "Nicotinamide salvaging" is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006771 name: riboflavin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "riboflavin metabolism" EXACT [] synonym: "vitamin B2 metabolic process" EXACT [] synonym: "vitamin B2 metabolism" EXACT [] synonym: "vitamin G metabolic process" EXACT [] synonym: "vitamin G metabolism" EXACT [] xref: Wikipedia:Riboflavin is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process [Term] id: GO:0006772 name: thiamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "thiamin metabolic process" EXACT [GOC:curators] synonym: "thiamin metabolism" EXACT [] synonym: "thiamine metabolism" EXACT [] synonym: "vitamin B1 metabolic process" EXACT [] synonym: "vitamin B1 metabolism" EXACT [] xref: Wikipedia:Thiamine is_a: GO:0042723 ! thiamine-containing compound metabolic process [Term] id: GO:0006774 name: vitamin B12 reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0009235 consider: GO:0050453 [Term] id: GO:0006775 name: fat-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fat-soluble vitamin metabolism" EXACT [] is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006776 name: vitamin A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "vitamin A metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0006775 ! fat-soluble vitamin metabolic process [Term] id: GO:0006777 name: Mo-molybdopterin cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257] subset: gosubset_prok synonym: "Mo-molybdopterin cofactor anabolism" EXACT [] synonym: "Mo-molybdopterin cofactor biosynthesis" EXACT [] synonym: "Mo-molybdopterin cofactor formation" EXACT [] synonym: "Mo-molybdopterin cofactor synthesis" EXACT [] synonym: "Moco biosynthesis" EXACT [] synonym: "Moco biosynthetic process" EXACT [] synonym: "molybdenum cofactor biosynthetic process" RELATED [] xref: MetaCyc:PWY-5354 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process [Term] id: GO:0006778 name: porphyrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "porphyrin metabolism" EXACT [] xref: Reactome:1253430 "Metabolism of porphyrins" xref: Reactome:1280234 "Metabolism of porphyrins" xref: Reactome:1299094 "Metabolism of porphyrins" xref: Reactome:1326810 "Metabolism of porphyrins" xref: Reactome:1352911 "Metabolism of porphyrins" xref: Reactome:1373117 "Metabolism of porphyrins" xref: Reactome:1393133 "Metabolism of porphyrins" xref: Reactome:1417620 "Metabolism of porphyrins" xref: Reactome:1450716 "Metabolism of porphyrins" xref: Reactome:1471176 "Metabolism of porphyrins" xref: Reactome:1496922 "Metabolism of porphyrins" xref: Reactome:1514310 "Metabolism of porphyrins" xref: Reactome:1521178 "Metabolism of porphyrins" xref: Reactome:1526918 "Metabolism of porphyrins" xref: Reactome:1532657 "Metabolism of porphyrins" xref: Reactome:1536082 "Metabolism of porphyrins" xref: Reactome:1538048 "Metabolism of porphyrins" xref: Reactome:1539329 "Metabolism of porphyrins" xref: Reactome:1540340 "Metabolism of porphyrins" xref: Reactome:189445 "Metabolism of porphyrins" xref: Wikipedia:Porphyrin is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006779 name: porphyrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "porphyrin anabolism" EXACT [] synonym: "porphyrin biosynthesis" EXACT [] synonym: "porphyrin formation" EXACT [] synonym: "porphyrin synthesis" EXACT [] is_a: GO:0006778 ! porphyrin metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0006780 name: uroporphyrinogen III biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai] subset: gosubset_prok synonym: "uroporphyrinogen III anabolism" EXACT [] synonym: "uroporphyrinogen III biosynthesis" EXACT [] synonym: "uroporphyrinogen III formation" EXACT [] synonym: "uroporphyrinogen III synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046502 ! uroporphyrinogen III metabolic process relationship: part_of GO:0006779 ! porphyrin biosynthetic process [Term] id: GO:0006781 name: succinyl-CoA pathway namespace: biological_process def: "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX." [GOC:isa_complete, ISBN:0879010479] subset: gosubset_prok synonym: "biosynthesis of protoporphyrin IX via succinyl CoA" EXACT [] synonym: "biosynthesis of protoporphyrin IX via succinyl-CoA" EXACT [] synonym: "biosynthetic process of protoporphyrin IX via succinyl CoA" EXACT [] synonym: "biosynthetic process of protoporphyrin IX via succinyl-CoA" EXACT [] synonym: "succinyl CoA pathway" EXACT [] is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0006779 ! porphyrin biosynthetic process relationship: part_of GO:0006780 ! uroporphyrinogen III biosynthetic process [Term] id: GO:0006782 name: protoporphyrinogen IX biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators] subset: gosubset_prok synonym: "protoporphyrinogen IX anabolism" EXACT [] synonym: "protoporphyrinogen IX biosynthesis" EXACT [] synonym: "protoporphyrinogen IX formation" EXACT [] synonym: "protoporphyrinogen IX synthesis" EXACT [] is_a: GO:0006779 ! porphyrin biosynthetic process is_a: GO:0046501 ! protoporphyrinogen IX metabolic process relationship: part_of GO:0006783 ! heme biosynthetic process [Term] id: GO:0006783 name: heme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl] subset: gosubset_prok synonym: "haem biosynthesis" EXACT [] synonym: "haem biosynthetic process" EXACT [] synonym: "heme anabolism" EXACT [] synonym: "heme biosynthesis" EXACT [] synonym: "heme formation" EXACT [] synonym: "heme synthesis" EXACT [] xref: MetaCyc:HEMESYN2-PWY xref: Reactome:1253432 "Heme biosynthesis" xref: Reactome:1280370 "Heme biosynthesis" xref: Reactome:1299207 "Heme biosynthesis" xref: Reactome:1326948 "Heme biosynthesis" xref: Reactome:1353043 "Heme biosynthesis" xref: Reactome:1373234 "Heme biosynthesis" xref: Reactome:1393252 "Heme biosynthesis" xref: Reactome:1417744 "Heme biosynthesis" xref: Reactome:1450844 "Heme biosynthesis" xref: Reactome:1471247 "Heme biosynthesis" xref: Reactome:1496921 "Heme biosynthesis" xref: Reactome:1514309 "Heme biosynthesis" xref: Reactome:1521177 "Heme biosynthesis" xref: Reactome:1526917 "Heme biosynthesis" xref: Reactome:1532656 "Heme biosynthesis" xref: Reactome:1536081 "Heme biosynthesis" xref: Reactome:1538047 "Heme biosynthesis" xref: Reactome:1539328 "Heme biosynthesis" xref: Reactome:1540339 "Heme biosynthesis" xref: Reactome:189451 "Heme biosynthesis" is_a: GO:0006779 ! porphyrin biosynthetic process is_a: GO:0042168 ! heme metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006784 name: heme a biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3." [CHEBI:24479, GOC:ai] subset: gosubset_prok synonym: "haem a biosynthesis" EXACT [] synonym: "haem a biosynthetic process" EXACT [] synonym: "heme a anabolism" EXACT [] synonym: "heme a biosynthesis" EXACT [] synonym: "heme a formation" EXACT [] synonym: "heme a synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046160 ! heme a metabolic process [Term] id: GO:0006785 name: heme b biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25] subset: gosubset_prok synonym: "haem b biosynthesis" EXACT [] synonym: "haem b biosynthetic process" EXACT [] synonym: "heme b anabolism" EXACT [] synonym: "heme b biosynthesis" EXACT [] synonym: "heme b formation" EXACT [] synonym: "heme b synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046492 ! heme b metabolic process [Term] id: GO:0006786 name: heme c biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208] subset: gosubset_prok synonym: "haem c biosynthesis" EXACT [] synonym: "haem c biosynthetic process" EXACT [] synonym: "heme c anabolism" EXACT [] synonym: "heme c biosynthesis" EXACT [] synonym: "heme c formation" EXACT [] synonym: "heme c synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046162 ! heme c metabolic process [Term] id: GO:0006787 name: porphyrin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "porphyrin breakdown" EXACT [] synonym: "porphyrin catabolism" EXACT [] synonym: "porphyrin degradation" EXACT [] is_a: GO:0006778 ! porphyrin metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0006788 name: heme oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah] subset: gosubset_prok synonym: "haem oxidation" EXACT [] is_a: GO:0042168 ! heme metabolic process is_a: GO:0055114 ! oxidation-reduction process relationship: part_of GO:0006787 ! porphyrin catabolic process [Term] id: GO:0006789 name: bilirubin conjugation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin." [DOI:10.1016/0305-0491(80)90243-6] subset: gosubset_prok xref: Reactome:1260563 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" xref: Reactome:1285610 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" xref: Reactome:1306500 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" xref: Reactome:1334025 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" xref: Reactome:1358296 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" xref: Reactome:1379359 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" xref: Reactome:1399904 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" xref: Reactome:1427218 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" xref: Reactome:1457555 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" xref: Reactome:159194 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP" is_a: GO:0006787 ! porphyrin catabolic process [Term] id: GO:0006790 name: sulfur compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: goslim_generic subset: gosubset_prok synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: Reactome:936621 "Sulfur compound metabolism" xref: Wikipedia:Sulfur_metabolism is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006791 name: sulfur utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: gosubset_prok synonym: "sulphur utilization" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006792 name: regulation of sulfur utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sulfur utilization." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of sulphur utilization" EXACT [] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0006791 ! sulfur utilization [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "phosphorus metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006794 name: phosphorus utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0006795 name: regulation of phosphorus utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0006794 ! phosphorus utilization [Term] id: GO:0006796 name: phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] subset: goslim_pombe subset: gosubset_prok synonym: "phosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process [Term] id: GO:0006797 name: polyphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyphosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate metabolic process [Term] id: GO:0006798 name: polyphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyphosphate breakdown" EXACT [] synonym: "polyphosphate catabolism" EXACT [] synonym: "polyphosphate degradation" EXACT [] is_a: GO:0006797 ! polyphosphate metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0006799 name: polyphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyphosphate anabolism" EXACT [] synonym: "polyphosphate biosynthesis" EXACT [] synonym: "polyphosphate formation" EXACT [] synonym: "polyphosphate synthesis" EXACT [] is_a: GO:0006797 ! polyphosphate metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006800 name: oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:jl, PMID:12115731] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. synonym: "oxygen and active oxygen species metabolism" EXACT [] synonym: "oxygen and AOS metabolism" EXACT [] synonym: "oxygen and reactive oxidative species metabolism" EXACT [] synonym: "oxygen and reactive oxygen intermediate metabolism" EXACT [] synonym: "oxygen and reactive oxygen species metabolism" EXACT [] synonym: "oxygen and ROI metabolism" EXACT [] synonym: "oxygen and ROS metabolic process" EXACT [] synonym: "oxygen and ROS metabolism" EXACT [] is_obsolete: true consider: GO:0072592 consider: GO:0072593 [Term] id: GO:0006801 name: superoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl] subset: gosubset_prok synonym: "oxygen free radical metabolic process" EXACT [] synonym: "oxygen free radical metabolism" EXACT [] synonym: "superoxide free radical metabolic process" EXACT [] synonym: "superoxide free radical metabolism" EXACT [] synonym: "superoxide metabolism" EXACT [] is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:0006802 name: catalase reaction namespace: biological_process def: "OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O." [GOC:jl, PMID:11245904] comment: This term was made obsolete because it represents a molecular function. synonym: "hydroperoxidase reaction" RELATED [] is_obsolete: true consider: GO:0004096 [Term] id: GO:0006803 name: glutathione conjugation reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0004364 [Term] id: GO:0006804 name: peroxidase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0004601 [Term] id: GO:0006805 name: xenobiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] subset: goslim_pir subset: gosubset_prok synonym: "xenobiotic metabolism" EXACT [] xref: Reactome:1252918 "Phase II conjugation" xref: Reactome:1252919 "Biological oxidations" xref: Reactome:1252963 "Phase 1 - Functionalization of compounds" xref: Reactome:1253297 "Conjugation of benzoate with glycine" xref: Reactome:1253298 "Conjugation of carboxylic acids" xref: Reactome:1253299 "Amino Acid conjugation" xref: Reactome:1253300 "Conjugation of salicylate with glycine" xref: Reactome:1253413 "Conjugation of phenylacetate with glutamine" xref: Reactome:1279852 "Phase II conjugation" xref: Reactome:1279853 "Biological oxidations" xref: Reactome:1279893 "Phase 1 - Functionalization of compounds" xref: Reactome:1280237 "Conjugation of benzoate with glycine" xref: Reactome:1280238 "Conjugation of carboxylic acids" xref: Reactome:1280239 "Amino Acid conjugation" xref: Reactome:1280240 "Conjugation of salicylate with glycine" xref: Reactome:1280353 "Conjugation of phenylacetate with glutamine" xref: Reactome:1298767 "Phase II conjugation" xref: Reactome:1298768 "Biological oxidations" xref: Reactome:1298804 "Phase 1 - Functionalization of compounds" xref: Reactome:1299097 "Conjugation of benzoate with glycine" xref: Reactome:1299098 "Conjugation of carboxylic acids" xref: Reactome:1299099 "Amino Acid conjugation" xref: Reactome:1299100 "Conjugation of salicylate with glycine" xref: Reactome:1299193 "Conjugation of phenylacetate with glutamine" xref: Reactome:1326421 "Phase II conjugation" xref: Reactome:1326422 "Biological oxidations" xref: Reactome:1326466 "Phase 1 - Functionalization of compounds" xref: Reactome:1326813 "Conjugation of benzoate with glycine" xref: Reactome:1326814 "Conjugation of carboxylic acids" xref: Reactome:1326815 "Amino Acid conjugation" xref: Reactome:1326816 "Conjugation of salicylate with glycine" xref: Reactome:1326931 "Conjugation of phenylacetate with glutamine" xref: Reactome:1352537 "Phase II conjugation" xref: Reactome:1352538 "Biological oxidations" xref: Reactome:1352580 "Phase 1 - Functionalization of compounds" xref: Reactome:1352914 "Conjugation of benzoate with glycine" xref: Reactome:1352915 "Conjugation of carboxylic acids" xref: Reactome:1352916 "Amino Acid conjugation" xref: Reactome:1352917 "Conjugation of salicylate with glycine" xref: Reactome:1353026 "Conjugation of phenylacetate with glutamine" xref: Reactome:1372765 "Phase II conjugation" xref: Reactome:1372766 "Biological oxidations" xref: Reactome:1372808 "Phase 1 - Functionalization of compounds" xref: Reactome:1373120 "Conjugation of benzoate with glycine" xref: Reactome:1373121 "Conjugation of carboxylic acids" xref: Reactome:1373122 "Amino Acid conjugation" xref: Reactome:1373123 "Conjugation of salicylate with glycine" xref: Reactome:1373216 "Conjugation of phenylacetate with glutamine" xref: Reactome:1392775 "Phase II conjugation" xref: Reactome:1392776 "Biological oxidations" xref: Reactome:1392820 "Phase 1 - Functionalization of compounds" xref: Reactome:1393136 "Conjugation of benzoate with glycine" xref: Reactome:1393137 "Conjugation of carboxylic acids" xref: Reactome:1393138 "Amino Acid conjugation" xref: Reactome:1393139 "Conjugation of salicylate with glycine" xref: Reactome:1393233 "Conjugation of phenylacetate with glutamine" xref: Reactome:1417252 "Phase II conjugation" xref: Reactome:1417253 "Biological oxidations" xref: Reactome:1417293 "Phase 1 - Functionalization of compounds" xref: Reactome:1450340 "Phase II conjugation" xref: Reactome:1450341 "Biological oxidations" xref: Reactome:1450383 "Phase 1 - Functionalization of compounds" xref: Reactome:1450719 "Conjugation of benzoate with glycine" xref: Reactome:1450720 "Conjugation of carboxylic acids" xref: Reactome:1450721 "Amino Acid conjugation" xref: Reactome:1450722 "Conjugation of salicylate with glycine" xref: Reactome:1450827 "Conjugation of phenylacetate with glutamine" xref: Reactome:1470881 "Phase II conjugation" xref: Reactome:1470882 "Biological oxidations" xref: Reactome:1470910 "Phase 1 - Functionalization of compounds" xref: Reactome:1482913 "Phase II conjugation" xref: Reactome:1482914 "Biological oxidations" xref: Reactome:1482950 "Phase 1 - Functionalization of compounds" xref: Reactome:1496709 "Phase II conjugation" xref: Reactome:1496710 "Biological oxidations" xref: Reactome:1496735 "Phase 1 - Functionalization of compounds" xref: Reactome:1514100 "Phase II conjugation" xref: Reactome:1514101 "Biological oxidations" xref: Reactome:1514125 "Phase 1 - Functionalization of compounds" xref: Reactome:1520925 "Phase II conjugation" xref: Reactome:1520926 "Biological oxidations" xref: Reactome:1521098 "Phase 1 - Functionalization of compounds" xref: Reactome:1526671 "Phase II conjugation" xref: Reactome:1526672 "Biological oxidations" xref: Reactome:1526700 "Phase 1 - Functionalization of compounds" xref: Reactome:1532398 "Phase II conjugation" xref: Reactome:1532399 "Biological oxidations" xref: Reactome:1532426 "Phase 1 - Functionalization of compounds" xref: Reactome:1536071 "Phase II conjugation" xref: Reactome:1536072 "Biological oxidations" xref: Reactome:1538034 "Phase II conjugation" xref: Reactome:1538035 "Biological oxidations" xref: Reactome:1539244 "Phase 1 - Functionalization of compounds" xref: Reactome:1539245 "Biological oxidations" xref: Reactome:1539316 "Phase II conjugation" xref: Reactome:1540327 "Conjugation of benzoate with glycine" xref: Reactome:1540328 "Conjugation of carboxylic acids" xref: Reactome:1540329 "Amino Acid conjugation" xref: Reactome:1540330 "Phase II conjugation" xref: Reactome:1540331 "Biological oxidations" xref: Reactome:1540332 "Conjugation of salicylate with glycine" xref: Reactome:1540338 "Conjugation of phenylacetate with glutamine" xref: Reactome:156580 "Phase II conjugation" xref: Reactome:156587 "Amino Acid conjugation" xref: Reactome:159424 "Conjugation of carboxylic acids" xref: Reactome:177128 "Conjugation of salicylate with glycine" xref: Reactome:177135 "Conjugation of benzoate with glycine" xref: Reactome:177162 "Conjugation of phenylacetate with glutamine" xref: Reactome:211859 "Biological oxidations" xref: Reactome:211945 "Phase 1 - Functionalization of compounds" xref: Wikipedia:Xenobiotic_metabolism is_a: GO:0044237 ! cellular metabolic process relationship: part_of GO:0071466 ! cellular response to xenobiotic stimulus [Term] id: GO:0006806 name: insecticide resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0017085 [Term] id: GO:0006807 name: nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node. subset: goslim_pir subset: gosubset_prok synonym: "nitrogen compound metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006808 name: regulation of nitrogen utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0019740 ! nitrogen utilization [Term] id: GO:0006809 name: nitric oxide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] subset: gosubset_prok synonym: "nitric oxide anabolism" EXACT [] synonym: "nitric oxide biosynthesis" EXACT [] synonym: "nitric oxide formation" EXACT [] synonym: "nitric oxide synthesis" EXACT [] is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046209 ! nitric oxide metabolic process [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "auxiliary transport protein activity" RELATED [GOC:mah] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] synonym: "transport accessory protein activity" RELATED [GOC:mah] is_a: GO:0051234 ! establishment of localization [Term] id: GO:0006811 name: ion transport namespace: biological_process def: "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok xref: Reactome:1253605 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1280536 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1299365 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1327122 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1353217 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1373394 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1393419 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1417914 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1451003 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1471387 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1483343 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1497030 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1514417 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1521279 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1527027 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1532761 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1536145 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1538084 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1539380 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:1540362 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:425393 "Transport of inorganic cations/anions and amino acids/oligopeptides" is_a: GO:0006810 ! transport [Term] id: GO:0006812 name: cation transport namespace: biological_process alt_id: GO:0006819 alt_id: GO:0015674 def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah] is_a: GO:0006811 ! ion transport [Term] id: GO:0006813 name: potassium ion transport namespace: biological_process alt_id: GO:0015458 def: "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "K+ conductance" EXACT [] synonym: "low voltage-dependent potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "low voltage-gated potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "potassium conductance" NARROW [] synonym: "potassium ion conductance" NARROW [] synonym: "potassium transport" EXACT [] synonym: "sodium/potassium transport" BROAD [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0006814 name: sodium ion transport namespace: biological_process alt_id: GO:0006834 alt_id: GO:0016974 def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "sodium transport" EXACT [] synonym: "sodium/potassium transport" BROAD [] synonym: "sodium:calcium exchange" NARROW [] synonym: "sodium:solute transport" NARROW [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0006815 name: sodium/potassium transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is a composite term that represents two individual processes. is_obsolete: true consider: GO:0006813 consider: GO:0006814 [Term] id: GO:0006816 name: calcium ion transport namespace: biological_process def: "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "calcium transport" EXACT [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium:calcium exchange" NARROW [] is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0006817 name: phosphate transport namespace: biological_process def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0006818 name: hydrogen transport namespace: biological_process def: "The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0006820 name: anion transport namespace: biological_process alt_id: GO:0006822 def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006811 ! ion transport [Term] id: GO:0006821 name: chloride transport namespace: biological_process def: "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0006823 name: heavy metal ion transport namespace: biological_process def: "OBSOLETE. The directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0030001 [Term] id: GO:0006824 name: cobalt ion transport namespace: biological_process def: "The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "cobalt transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport [Term] id: GO:0006825 name: copper ion transport namespace: biological_process def: "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006826 name: iron ion transport namespace: biological_process alt_id: GO:0015681 def: "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "iron transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006827 name: high-affinity iron ion transport namespace: biological_process def: "The directed, high-affinity movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] subset: gosubset_prok synonym: "high affinity iron ion transport" EXACT [] is_a: GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0006828 name: manganese ion transport namespace: biological_process def: "The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006829 name: zinc ion transport namespace: biological_process def: "The directed movement of zinc (Zn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "zinc transport" EXACT [GOC:mah] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0006830 name: high-affinity zinc ion transport namespace: biological_process def: "The directed, high-affinity movement of zinc (Zn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] is_a: GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0006831 name: low-affinity zinc ion transport namespace: biological_process def: "The directed, low-affinity movement of zinc (Zn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] is_a: GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0006832 name: small molecule transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0006810 [Term] id: GO:0006833 name: water transport namespace: biological_process def: "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok xref: Reactome:1253203 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1253204 "Aquaporin-mediated transport" xref: Reactome:1253763 "Passive Transport by Aquaporins" xref: Reactome:1280137 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1280138 "Aquaporin-mediated transport" xref: Reactome:1280696 "Passive Transport by Aquaporins" xref: Reactome:1299017 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1299018 "Aquaporin-mediated transport" xref: Reactome:1299520 "Passive Transport by Aquaporins" xref: Reactome:1326709 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1326710 "Aquaporin-mediated transport" xref: Reactome:1327280 "Passive Transport by Aquaporins" xref: Reactome:1352821 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1352822 "Aquaporin-mediated transport" xref: Reactome:1353377 "Passive Transport by Aquaporins" xref: Reactome:1373030 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1373031 "Aquaporin-mediated transport" xref: Reactome:1393047 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1393048 "Aquaporin-mediated transport" xref: Reactome:1417523 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1417524 "Aquaporin-mediated transport" xref: Reactome:1418071 "Passive Transport by Aquaporins" xref: Reactome:1450619 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1450620 "Aquaporin-mediated transport" xref: Reactome:1471121 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1471122 "Aquaporin-mediated transport" xref: Reactome:1483187 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1483188 "Aquaporin-mediated transport" xref: Reactome:1497085 "Passive Transport by Aquaporins" xref: Reactome:1497086 "Aquaporin-mediated transport" xref: Reactome:1497087 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1514472 "Passive Transport by Aquaporins" xref: Reactome:1514473 "Aquaporin-mediated transport" xref: Reactome:1514474 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1521082 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1521083 "Aquaporin-mediated transport" xref: Reactome:1526860 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1526861 "Aquaporin-mediated transport" xref: Reactome:1527041 "Passive Transport by Aquaporins" xref: Reactome:1532587 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1532588 "Aquaporin-mediated transport" xref: Reactome:1536156 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1536157 "Aquaporin-mediated transport" xref: Reactome:1538101 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1538102 "Aquaporin-mediated transport" xref: Reactome:1540387 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:1540388 "Aquaporin-mediated transport" xref: Reactome:432040 "Regulation of Water Balance by Renal Aquaporins" xref: Reactome:432047 "Passive Transport by Aquaporins" xref: Reactome:445717 "Aquaporin-mediated transport" is_a: GO:0042044 ! fluid transport [Term] id: GO:0006835 name: dicarboxylic acid transport namespace: biological_process alt_id: GO:0006841 def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006836 name: neurotransmitter transport namespace: biological_process def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] subset: goslim_pir synonym: "sodium:neurotransmitter transport" NARROW [] is_a: GO:0006810 ! transport [Term] id: GO:0006837 name: serotonin transport namespace: biological_process def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0015844 ! monoamine transport [Term] id: GO:0006838 name: allantoin/allantoate transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is a composite term that represents two individual processes. is_obsolete: true consider: GO:0015719 consider: GO:0015720 [Term] id: GO:0006839 name: mitochondrial transport namespace: biological_process def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai] synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW [] synonym: "mitochondrial aspartate/glutamate transport" NARROW [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] is_a: GO:0046907 ! intracellular transport [Term] id: GO:0006840 name: mitochondrial alpha-ketoglutarate/malate transport namespace: biological_process def: "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. synonym: "mitochondrial oxoglutarate/malate transport" EXACT [] is_obsolete: true replaced_by: GO:0006839 replaced_by: GO:0015367 replaced_by: GO:0015742 replaced_by: GO:0015743 [Term] id: GO:0006842 name: tricarboxylic acid transport namespace: biological_process def: "The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006843 name: mitochondrial citrate transport namespace: biological_process def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a mitochondrion." [GOC:ai] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015746 ! citrate transport [Term] id: GO:0006844 name: acyl carnitine transport namespace: biological_process def: "The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai] is_a: GO:0051181 ! cofactor transport [Term] id: GO:0006845 name: mitochondrial aspartate/glutamate transport namespace: biological_process def: "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true replaced_by: GO:0006839 replaced_by: GO:0015810 replaced_by: GO:0015813 [Term] id: GO:0006846 name: acetate transport namespace: biological_process def: "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015711 ! organic anion transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0006847 name: plasma membrane acetate transport namespace: biological_process def: "The directed movement of acetate across a plasma membrane." [GOC:ai] is_a: GO:0035433 ! acetate transmembrane transport [Term] id: GO:0006848 name: pyruvate transport namespace: biological_process def: "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015711 ! organic anion transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0006849 name: plasma membrane pyruvate transport namespace: biological_process def: "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane." [GOC:ai] is_a: GO:0006848 ! pyruvate transport [Term] id: GO:0006850 name: mitochondrial pyruvate transport namespace: biological_process def: "The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0006848 ! pyruvate transport [Term] id: GO:0006851 name: mitochondrial calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion." [GOC:ai] synonym: "mitochondrial calcium transport" EXACT [] is_a: GO:0006816 ! calcium ion transport is_a: GO:0006839 ! mitochondrial transport [Term] id: GO:0006852 name: mitochondrial sodium/calcium ion exchange namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents function rather than a process. synonym: "mitochondrial sodium/calcium exchange" EXACT [] is_obsolete: true replaced_by: GO:0006814 replaced_by: GO:0006816 replaced_by: GO:0006839 consider: GO:0005432 [Term] id: GO:0006853 name: carnitine shuttle namespace: biological_process def: "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine." [ISBN:0198547684] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. xref: Reactome:1253067 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1280003 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1298894 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1326573 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1352685 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1372901 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1393345 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1417394 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1450492 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1471005 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1483030 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1496799 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1514189 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1521025 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1526762 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1532493 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:1536022 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:200425 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Wikipedia:Carnitine#Role_in_fatty_acid_metabolism is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015879 ! carnitine transport is_a: GO:0015909 ! long-chain fatty acid transport is_a: GO:0032365 ! intracellular lipid transport [Term] id: GO:0006854 name: ATP/ADP exchange namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0005471 [Term] id: GO:0006855 name: drug transmembrane transport namespace: biological_process def: "The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:ai, GOC:bf] subset: gosubset_prok synonym: "multidrug transport" RELATED [] is_a: GO:0015893 ! drug transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0006856 name: eye pigment precursor transport namespace: biological_process def: "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006810 ! transport relationship: part_of GO:0048066 ! developmental pigmentation [Term] id: GO:0006857 name: oligopeptide transport namespace: biological_process def: "The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015833 ! peptide transport [Term] id: GO:0006858 name: extracellular transport namespace: biological_process def: "The transport of substances that occurs outside cells." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0006859 name: extracellular carbohydrate transport namespace: biological_process def: "The directed extracellular movement of carbohydrates." [GOC:ai] subset: gosubset_prok is_a: GO:0006858 ! extracellular transport is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0006860 name: extracellular amino acid transport namespace: biological_process def: "The directed extracellular movement of amino acids." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0006862 name: nucleotide transport namespace: biological_process def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport [Term] id: GO:0006863 name: purine base transport namespace: biological_process alt_id: GO:0015852 def: "The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:26386, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine base transmembrane transport" EXACT [GOC:mah] synonym: "purine nucleobase transport" EXACT [CHEBI:26386] synonym: "purine transmembrane transport" RELATED [GOC:mah] synonym: "purine transport" RELATED [GOC:curators] is_a: GO:0015851 ! nucleobase transport is_a: GO:0072530 ! purine-containing compound transmembrane transport [Term] id: GO:0006864 name: pyrimidine nucleotide transport namespace: biological_process def: "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0006862 ! nucleotide transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport [Term] id: GO:0006865 name: amino acid transport namespace: biological_process alt_id: GO:0006866 def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok xref: Reactome:1253603 "Amino acid transport across the plasma membrane" xref: Reactome:1280534 "Amino acid transport across the plasma membrane" xref: Reactome:1299363 "Amino acid transport across the plasma membrane" xref: Reactome:1327120 "Amino acid transport across the plasma membrane" xref: Reactome:1353215 "Amino acid transport across the plasma membrane" xref: Reactome:1373392 "Amino acid transport across the plasma membrane" xref: Reactome:1393417 "Amino acid transport across the plasma membrane" xref: Reactome:1417912 "Amino acid transport across the plasma membrane" xref: Reactome:1451001 "Amino acid transport across the plasma membrane" xref: Reactome:1471385 "Amino acid transport across the plasma membrane" xref: Reactome:1483341 "Amino acid transport across the plasma membrane" xref: Reactome:1497028 "Amino acid transport across the plasma membrane" xref: Reactome:1514415 "Amino acid transport across the plasma membrane" xref: Reactome:1521277 "Amino acid transport across the plasma membrane" xref: Reactome:1538082 "Amino acid transport across the plasma membrane" xref: Reactome:1540360 "Amino acid transport across the plasma membrane" xref: Reactome:352230 "Amino acid transport across the plasma membrane" is_a: GO:0015837 ! amine transport is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006867 name: asparagine transport namespace: biological_process def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-asparagine transport" NARROW [] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0006868 name: glutamine transport namespace: biological_process alt_id: GO:0015815 def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-glutamine transport" NARROW [] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0006869 name: lipid transport namespace: biological_process def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0071702 ! organic substance transport relationship: part_of GO:0010876 ! lipid localization [Term] id: GO:0006873 name: cellular ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of ions at the level of a cell." [GOC:mah] subset: gosubset_prok is_a: GO:0050801 ! ion homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0006874 name: cellular calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] synonym: "regulation of calcium ion concentration" BROAD [] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055074 ! calcium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006875 name: cellular metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell." [GOC:ai, GOC:mah] subset: gosubset_prok synonym: "cellular heavy metal ion homeostasis" NARROW [] is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0006876 name: cellular cadmium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cadmium ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cadmium homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055073 ! cadmium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006877 name: cellular cobalt ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cobalt ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cobalt homeostasis" BROAD [] is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055068 ! cobalt ion homeostasis [Term] id: GO:0006878 name: cellular copper ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell." [GOC:ai, GOC:mah] subset: gosubset_prok synonym: "copper homeostasis" BROAD [] is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055070 ! copper ion homeostasis [Term] id: GO:0006879 name: cellular iron ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah] subset: gosubset_prok synonym: "iron homeostasis" BROAD [] xref: Reactome:1253431 "Iron uptake and transport" xref: Reactome:1280369 "Iron uptake and transport" xref: Reactome:1299206 "Iron uptake and transport" xref: Reactome:1326947 "Iron uptake and transport" xref: Reactome:1353042 "Iron uptake and transport" xref: Reactome:1373233 "Iron uptake and transport" xref: Reactome:1393251 "Iron uptake and transport" xref: Reactome:1417743 "Iron uptake and transport" xref: Reactome:1450843 "Iron uptake and transport" xref: Reactome:1471246 "Iron uptake and transport" xref: Reactome:1483452 "Iron uptake and transport" xref: Reactome:1497091 "Iron uptake and transport" xref: Reactome:1514478 "Iron uptake and transport" xref: Reactome:1521347 "Iron uptake and transport" xref: Reactome:1536153 "Iron uptake and transport" xref: Reactome:917937 "Iron uptake and transport" is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055072 ! iron ion homeostasis [Term] id: GO:0006880 name: intracellular sequestering of iron ion namespace: biological_process def: "The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." [GOC:ai] subset: gosubset_prok synonym: "intracellular iron ion retention" EXACT [] synonym: "intracellular iron ion sequestering" EXACT [] synonym: "intracellular iron ion sequestration" EXACT [] synonym: "intracellular iron ion storage" EXACT [] synonym: "intracellular retention of iron ion" EXACT [] synonym: "intracellular sequestration of iron ion" EXACT [] synonym: "intracellular storage of iron ion" EXACT [] is_a: GO:0051238 ! sequestering of metal ion is_a: GO:0051651 ! maintenance of location in cell relationship: part_of GO:0006879 ! cellular iron ion homeostasis [Term] id: GO:0006881 name: extracellular sequestering of iron ion namespace: biological_process def: "The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." [GOC:ai] synonym: "extracellular iron ion retention" EXACT [] synonym: "extracellular iron ion sequestering" EXACT [] synonym: "extracellular iron ion sequestration" EXACT [] synonym: "extracellular iron ion storage" EXACT [] synonym: "extracellular retention of iron ion" EXACT [] synonym: "extracellular sequestration of iron ion" EXACT [] synonym: "extracellular storage of iron ion" EXACT [] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0033212 ! iron assimilation [Term] id: GO:0006882 name: cellular zinc ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "zinc homeostasis" BROAD [] is_a: GO:0055069 ! zinc ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006883 name: cellular sodium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell." [GOC:ai, GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis is_a: GO:0055078 ! sodium ion homeostasis [Term] id: GO:0006884 name: cell volume homeostasis namespace: biological_process def: "Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0019725 ! cellular homeostasis [Term] id: GO:0006885 name: regulation of pH namespace: biological_process def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] subset: gosubset_prok is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport relationship: part_of GO:0034613 ! cellular protein localization [Term] id: GO:0006887 name: exocytosis namespace: biological_process alt_id: GO:0016194 alt_id: GO:0016195 def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] subset: gosubset_prok synonym: "nonselective vesicle exocytosis" RELATED [] synonym: "vesicle exocytosis" EXACT [] xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0006888 name: ER to Golgi vesicle-mediated transport namespace: biological_process alt_id: GO:0048221 def: "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] synonym: "endoplasmic reticulum to Golgi transport" EXACT [] synonym: "endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [] synonym: "ER to Golgi transport" EXACT [] synonym: "rough endoplasmic reticulum to cis-Golgi transport" EXACT [] synonym: "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [] synonym: "rough ER to cis-Golgi transport" EXACT [] synonym: "rough ER to cis-Golgi vesicle-mediated transport" EXACT [] xref: Reactome:1253553 "ER to Golgi Transport" xref: Reactome:1280492 "ER to Golgi Transport" xref: Reactome:1299320 "ER to Golgi Transport" xref: Reactome:1327071 "ER to Golgi Transport" xref: Reactome:1353165 "ER to Golgi Transport" xref: Reactome:1373343 "ER to Golgi Transport" xref: Reactome:1393365 "ER to Golgi Transport" xref: Reactome:1417863 "ER to Golgi Transport" xref: Reactome:1450951 "ER to Golgi Transport" xref: Reactome:1471332 "ER to Golgi Transport" xref: Reactome:1483300 "ER to Golgi Transport" xref: Reactome:1496984 "ER to Golgi Transport" xref: Reactome:1514371 "ER to Golgi Transport" xref: Reactome:1521247 "ER to Golgi Transport" xref: Reactome:1526962 "ER to Golgi Transport" xref: Reactome:1532698 "ER to Golgi Transport" xref: Reactome:1536104 "ER to Golgi Transport" xref: Reactome:199977 "ER to Golgi Transport" is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006889 name: regulation of calcium in ER namespace: biological_process def: "OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum." [GOC:go_curators] comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). is_obsolete: true consider: GO:0005783 consider: GO:0006874 [Term] id: GO:0006890 name: retrograde vesicle-mediated transport, Golgi to ER namespace: biological_process alt_id: GO:0048220 def: "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524] synonym: "cis-Golgi to rough endoplasmic reticulum transport" EXACT [] synonym: "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [] synonym: "cis-Golgi to rough ER transport" EXACT [] synonym: "cis-Golgi to rough ER vesicle-mediated transport" EXACT [] synonym: "retrograde (Golgi to ER) transport" EXACT [] synonym: "retrograde transport, Golgi to endoplasmic reticulum" EXACT [] synonym: "retrograde transport, Golgi to ER" EXACT [] synonym: "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [] xref: Reactome:1253532 "Golgi to ER Retrograde Transport" xref: Reactome:1280471 "Golgi to ER Retrograde Transport" xref: Reactome:1299296 "Golgi to ER Retrograde Transport" xref: Reactome:1327049 "Golgi to ER Retrograde Transport" xref: Reactome:1353143 "Golgi to ER Retrograde Transport" xref: Reactome:1373322 "Golgi to ER Retrograde Transport" xref: Reactome:1393344 "Golgi to ER Retrograde Transport" xref: Reactome:1417840 "Golgi to ER Retrograde Transport" xref: Reactome:1450931 "Golgi to ER Retrograde Transport" xref: Reactome:1471318 "Golgi to ER Retrograde Transport" xref: Reactome:1483290 "Golgi to ER Retrograde Transport" xref: Reactome:1496977 "Golgi to ER Retrograde Transport" xref: Reactome:1514364 "Golgi to ER Retrograde Transport" xref: Reactome:1521237 "Golgi to ER Retrograde Transport" xref: Reactome:1526950 "Golgi to ER Retrograde Transport" xref: Reactome:1532685 "Golgi to ER Retrograde Transport" xref: Reactome:1536098 "Golgi to ER Retrograde Transport" xref: Reactome:199983 "Golgi to ER Retrograde Transport" is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006891 name: intra-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] synonym: "intra-Golgi transport" EXACT [] is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006892 name: post-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] synonym: "post-Golgi transport" EXACT [] xref: Reactome:1253602 "trans-Golgi Network Vesicle Budding" xref: Reactome:1280533 "trans-Golgi Network Vesicle Budding" xref: Reactome:1299402 "trans-Golgi Network Vesicle Budding" xref: Reactome:1327119 "trans-Golgi Network Vesicle Budding" xref: Reactome:1353214 "trans-Golgi Network Vesicle Budding" xref: Reactome:1373390 "trans-Golgi Network Vesicle Budding" xref: Reactome:1393416 "trans-Golgi Network Vesicle Budding" xref: Reactome:1417910 "trans-Golgi Network Vesicle Budding" xref: Reactome:1451000 "trans-Golgi Network Vesicle Budding" xref: Reactome:1471382 "trans-Golgi Network Vesicle Budding" xref: Reactome:1483338 "trans-Golgi Network Vesicle Budding" xref: Reactome:1497020 "trans-Golgi Network Vesicle Budding" xref: Reactome:1514407 "trans-Golgi Network Vesicle Budding" xref: Reactome:1521283 "trans-Golgi Network Vesicle Budding" xref: Reactome:1526981 "trans-Golgi Network Vesicle Budding" xref: Reactome:1532716 "trans-Golgi Network Vesicle Budding" xref: Reactome:199992 "trans-Golgi Network Vesicle Budding" is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006893 name: Golgi to plasma membrane transport namespace: biological_process def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport [Term] id: GO:0006894 name: Golgi to secretory vesicle transport namespace: biological_process def: "OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release." [ISBN:0716731363] comment: This term was made obsolete because it mixes two processes that can be better captured in separate terms. synonym: "Golgi to secretory vesicle transport, vesicle-mediated" EXACT [] is_obsolete: true consider: GO:0055107 consider: GO:0055108 [Term] id: GO:0006895 name: Golgi to endosome transport namespace: biological_process alt_id: GO:0048218 def: "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832] synonym: "Golgi to endosome vesicle-mediated transport" EXACT [] synonym: "TGN to endosome transport" EXACT [] synonym: "trans-Golgi to endosome transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0016197 ! endosome transport [Term] id: GO:0006896 name: Golgi to vacuole transport namespace: biological_process def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] synonym: "Golgi to vacuole vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0006897 name: endocytosis namespace: biological_process alt_id: GO:0016193 alt_id: GO:0016196 def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] subset: gosubset_prok synonym: "nonselective vesicle endocytosis" RELATED [] synonym: "plasma membrane invagination" EXACT [] synonym: "vesicle endocytosis" EXACT [] xref: Wikipedia:Endocytosis is_a: GO:0010324 ! membrane invagination is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006898 name: receptor-mediated endocytosis namespace: biological_process def: "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] synonym: "receptor mediated endocytosis" EXACT [] xref: Reactome:1235147 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:1235149 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:1235154 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:1235163 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:1235169 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:1235661 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:1235676 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:1235734 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:1253384 "LDL-mediated lipid transport" xref: Reactome:1262520 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:1262522 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:1262525 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:1262532 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:1262536 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:1262956 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:1262969 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:1263027 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:1280324 "LDL-mediated lipid transport" xref: Reactome:1287279 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:1287281 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:1287288 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:1287299 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:1287307 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:1287592 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:1287609 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:1287664 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:1299173 "LDL-mediated lipid transport" xref: Reactome:1308770 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:1308772 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:1308780 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:1308792 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:1308801 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:1309265 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:1309283 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:1309351 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:1326902 "LDL-mediated lipid transport" xref: Reactome:1335617 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:1335619 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:1335622 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:1335629 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:1335633 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:1336294 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:1336309 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:1336334 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:1352994 "LDL-mediated lipid transport" xref: Reactome:1373386 "LDL-mediated lipid transport" xref: Reactome:1393411 "LDL-mediated lipid transport" xref: Reactome:1401748 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:1401750 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:1401757 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:1401771 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:1401779 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:1402279 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:1402334 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:1417698 "LDL-mediated lipid transport" xref: Reactome:1429744 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:1429748 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:1429755 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:1429772 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:1429780 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:1430292 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:1430322 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:1430374 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:1450800 "LDL-mediated lipid transport" xref: Reactome:171052 "LDL-mediated lipid transport" xref: Reactome:171059 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:171087 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:171106 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:171118 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:171122 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:171141 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)" xref: Reactome:174624 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:174657 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:174808 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Wikipedia:Receptor-mediated_endocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006900 name: membrane budding namespace: biological_process alt_id: GO:0006902 def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] synonym: "membrane evagination" EXACT [] synonym: "nonselective vesicle assembly" RELATED [] synonym: "vesicle biosynthesis" EXACT [] synonym: "vesicle budding" RELATED [] synonym: "vesicle formation" EXACT [] is_a: GO:0016044 ! cellular membrane organization is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006901 name: vesicle coating namespace: biological_process def: "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] synonym: "vesicle coat assembly" BROAD [] is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0006900 ! membrane budding [Term] id: GO:0006903 name: vesicle targeting namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: part_of GO:0016192 ! vesicle-mediated transport relationship: part_of GO:0051650 ! establishment of vesicle localization [Term] id: GO:0006904 name: vesicle docking involved in exocytosis namespace: biological_process def: "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid] subset: gosubset_prok synonym: "vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb] is_a: GO:0048278 ! vesicle docking relationship: part_of GO:0006887 ! exocytosis [Term] id: GO:0006905 name: vesicle transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0016192 [Term] id: GO:0006906 name: vesicle fusion namespace: biological_process def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] is_a: GO:0006944 ! cellular membrane fusion is_a: GO:0016050 ! vesicle organization is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006907 name: pinocytosis namespace: biological_process alt_id: GO:0006908 def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "clathrin-independent pinocytosis" NARROW [] synonym: "fluid-phase endocytosis" EXACT [] xref: Wikipedia:Pinocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006909 name: phagocytosis namespace: biological_process def: "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Phagocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006910 name: phagocytosis, recognition namespace: biological_process def: "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149 "Fundamental Immunology"] comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'. synonym: "recognition of phagocytosed substance by phagocytic cell" EXACT [] is_a: GO:0008037 ! cell recognition relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0006911 name: phagocytosis, engulfment namespace: biological_process def: "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149 "Fundamental Immunology"] synonym: "phagosome biosynthesis" RELATED [] synonym: "phagosome formation" RELATED [] is_a: GO:0010324 ! membrane invagination relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0006912 name: phagosome formation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because of the ambiguity in its meaning. is_obsolete: true consider: GO:0001845 consider: GO:0006911 [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process alt_id: GO:0000063 def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] subset: goslim_generic subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] is_a: GO:0051169 ! nuclear transport [Term] id: GO:0006914 name: autophagy namespace: biological_process alt_id: GO:0016238 def: "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [ISBN:0198547684, PMID:11099404, PMID:9412464] subset: goslim_pir synonym: "chaperone-mediated autophagy" EXACT [] xref: Wikipedia:Autophagy_(cellular) is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0006915 name: apoptosis namespace: biological_process alt_id: GO:0008632 def: "A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:18846107] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: Reactome:109581 "Apoptosis" xref: Reactome:1252953 "Apoptosis" xref: Reactome:1253485 "NADE modulates death signalling" xref: Reactome:1253487 "NRAGE signals death through JNK" xref: Reactome:1253559 "NRIF signals cell death from the nucleus" xref: Reactome:1279984 "Apoptosis" xref: Reactome:1280422 "NADE modulates death signalling" xref: Reactome:1280424 "NRAGE signals death through JNK" xref: Reactome:1280425 "NRIF signals cell death from the nucleus" xref: Reactome:1298877 "Apoptosis" xref: Reactome:1299256 "NADE modulates death signalling" xref: Reactome:1299258 "NRAGE signals death through JNK" xref: Reactome:1299325 "NRIF signals cell death from the nucleus" xref: Reactome:1326456 "Apoptosis" xref: Reactome:1327001 "NADE modulates death signalling" xref: Reactome:1327003 "NRAGE signals death through JNK" xref: Reactome:1327004 "NRIF signals cell death from the nucleus" xref: Reactome:1352572 "Apoptosis" xref: Reactome:1353095 "NADE modulates death signalling" xref: Reactome:1353097 "NRAGE signals death through JNK" xref: Reactome:1353098 "NRIF signals cell death from the nucleus" xref: Reactome:1372799 "Apoptosis" xref: Reactome:1373284 "NRAGE signals death through JNK" xref: Reactome:1373286 "NRIF signals cell death from the nucleus" xref: Reactome:1392809 "Apoptosis" xref: Reactome:1393299 "NRAGE signals death through JNK" xref: Reactome:1393372 "NRIF signals cell death from the nucleus" xref: Reactome:1417383 "Apoptosis" xref: Reactome:1417797 "NRAGE signals death through JNK" xref: Reactome:1417869 "NRIF signals cell death from the nucleus" xref: Reactome:1450375 "Apoptosis" xref: Reactome:1450896 "NRAGE signals death through JNK" xref: Reactome:1450958 "NRIF signals cell death from the nucleus" xref: Reactome:1471339 "NRAGE signals death through JNK" xref: Reactome:1471362 "Apoptosis" xref: Reactome:1483249 "NRAGE signals death through JNK" xref: Reactome:1483323 "Apoptosis" xref: Reactome:1496989 "NRAGE signals death through JNK" xref: Reactome:1497027 "Apoptosis" xref: Reactome:1514376 "NRAGE signals death through JNK" xref: Reactome:1514414 "Apoptosis" xref: Reactome:1521264 "Apoptosis" xref: Reactome:1526930 "NRAGE signals death through JNK" xref: Reactome:1526973 "Apoptosis" xref: Reactome:1532666 "NRAGE signals death through JNK" xref: Reactome:1532709 "Apoptosis" xref: Reactome:1536054 "Apoptosis" xref: Reactome:193648 "NRAGE signals death through JNK" xref: Reactome:205025 "NADE modulates death signalling" xref: Reactome:205043 "NRIF signals cell death from the nucleus" xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death [Term] id: GO:0006916 name: anti-apoptosis namespace: biological_process def: "A process which directly inhibits any of the steps required for cell death by apoptosis." [GOC:go_curators] synonym: "apoptosis inhibitor activity" RELATED [] xref: Reactome:1253481 "p75NTR signals via NF-kB" xref: Reactome:1280416 "p75NTR signals via NF-kB" xref: Reactome:1299253 "p75NTR signals via NF-kB" xref: Reactome:1326997 "p75NTR signals via NF-kB" xref: Reactome:1353092 "p75NTR signals via NF-kB" xref: Reactome:1373280 "p75NTR signals via NF-kB" xref: Reactome:1393374 "p75NTR signals via NF-kB" xref: Reactome:1417793 "p75NTR signals via NF-kB" xref: Reactome:1450893 "p75NTR signals via NF-kB" xref: Reactome:1471346 "p75NTR signals via NF-kB" xref: Reactome:193639 "p75NTR signals via NF-kB" is_a: GO:0043066 ! negative regulation of apoptosis [Term] id: GO:0006917 name: induction of apoptosis namespace: biological_process def: "A process that directly activates any of the steps required for cell death by apoptosis." [GOC:go_curators] synonym: "activation of apoptosis" EXACT [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" BROAD [] synonym: "commitment to apoptosis" EXACT [] synonym: "induction of apoptosis by p53" NARROW [] is_a: GO:0012502 ! induction of programmed cell death is_a: GO:0043065 ! positive regulation of apoptosis [Term] id: GO:0006918 name: induction of apoptosis by p53 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more accurate terms were created. is_obsolete: true consider: GO:0006917 [Term] id: GO:0006919 name: activation of caspase activity namespace: biological_process def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:dph, GOC:jl, GOC:tb, PMID:14744432, Wikipedia:Caspase] synonym: "caspase activation" EXACT [GOC:dph, GOC:tb] xref: Reactome:1253014 "Activation of Pro-Caspase 8" xref: Reactome:1280196 "Activation of Pro-Caspase 8" xref: Reactome:1299066 "Activation of Pro-Caspase 8" xref: Reactome:1326518 "Activation of Pro-Caspase 8" xref: Reactome:1352625 "Activation of Pro-Caspase 8" xref: Reactome:1372853 "Activation of Pro-Caspase 8" xref: Reactome:1392866 "Activation of Pro-Caspase 8" xref: Reactome:1450433 "Activation of Pro-Caspase 8" xref: Reactome:69416 "Activation of Pro-Caspase 8" is_a: GO:0043280 ! positive regulation of caspase activity relationship: part_of GO:0006915 ! apoptosis [Term] id: GO:0006920 name: commitment to apoptosis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more accurate terms were created. is_obsolete: true consider: GO:0006917 [Term] id: GO:0006921 name: cellular component disassembly involved in apoptosis namespace: biological_process def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:tb] synonym: "disassembly of cell structures" BROAD [] xref: Reactome:1253537 "Apoptotic execution phase" xref: Reactome:1280476 "Apoptotic execution phase" xref: Reactome:1299299 "Apoptotic execution phase" xref: Reactome:1327054 "Apoptotic execution phase" xref: Reactome:1353148 "Apoptotic execution phase" xref: Reactome:1373327 "Apoptotic execution phase" xref: Reactome:1393351 "Apoptotic execution phase" xref: Reactome:1417845 "Apoptotic execution phase" xref: Reactome:1450936 "Apoptotic execution phase" xref: Reactome:1471361 "Apoptotic execution phase" xref: Reactome:1483322 "Apoptotic execution phase" xref: Reactome:1497026 "Apoptotic execution phase" xref: Reactome:1514413 "Apoptotic execution phase" xref: Reactome:1521263 "Apoptotic execution phase" xref: Reactome:1526972 "Apoptotic execution phase" xref: Reactome:1532708 "Apoptotic execution phase" xref: Reactome:1536122 "Apoptotic execution phase" xref: Reactome:75153 "Apoptotic execution phase" is_a: GO:0071845 ! cellular component disassembly at cellular level relationship: part_of GO:0006915 ! apoptosis [Term] id: GO:0006922 name: cleavage of lamin namespace: biological_process def: "The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina." [GOC:mah, ISBN:0815332181] is_a: GO:0006923 ! cleavage of cytoskeletal proteins involved in apoptosis [Term] id: GO:0006923 name: cleavage of cytoskeletal proteins involved in apoptosis namespace: biological_process def: "The proteolytic degradation of cytoskeletal proteins that contributes to apoptosis, leading to the collapse of cytoskeletal structures." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815332181] synonym: "apoptotic cleavage of cytoskeletal proteins" EXACT [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0006921 ! cellular component disassembly involved in apoptosis relationship: part_of GO:0007010 ! cytoskeleton organization [Term] id: GO:0006924 name: activation-induced cell death of T cells namespace: biological_process def: "A type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors." [GOC:add, ISBN:0781765196, PMID:12414721, PMID:12752672] synonym: "activated T cell apoptosis" BROAD [GOC:add] synonym: "activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "AICD" BROAD [GOC:add] synonym: "antigen-driven apoptosis" BROAD [GOC:add] is_a: GO:0070231 ! T cell apoptosis relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0006925 name: inflammatory cell apoptosis namespace: biological_process def: "The process of apoptosis in inflammatory cells, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, http://www.mercksource.com/] synonym: "apoptosis of inflammatory cells" EXACT [] synonym: "inflammatory cell programmed cell death by apoptosis" EXACT [] synonym: "killing of inflammatory cells" EXACT [] synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT [] synonym: "programmed cell death, inflammatory cells" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0006926 name: virus-infected cell apoptosis namespace: biological_process def: "The process of apoptosis in cells infected with a virus." [GOC:jl] synonym: "apoptosis of virus-infected cells" EXACT [] synonym: "killing virus-infected cells" EXACT [] synonym: "programmed cell death of virus-infected cells by apoptosis" EXACT [] synonym: "programmed cell death, virus-infected cells" EXACT [] synonym: "virus-infected cell programmed cell death by apoptosis" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0006927 name: transformed cell apoptosis namespace: biological_process def: "The process of apoptosis in transformed cells, cells that have undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm." [GOC:jl, MeSH:C04.697.152] synonym: "apoptosis of transformed cells" EXACT [] synonym: "killing transformed cells" EXACT [] synonym: "programmed cell death of transformed cells by apoptosis" EXACT [] synonym: "programmed cell death, transformed cells" EXACT [] synonym: "transformed cell programmed cell death by apoptosis" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0006928 name: cellular component movement namespace: biological_process def: "The directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] comment: Note that in GO cellular components include whole cells (cell is_a cellular component). subset: goslim_pir subset: gosubset_prok synonym: "cell movement" RELATED [] synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl] is_a: GO:0009987 ! cellular process [Term] id: GO:0006929 name: substrate-dependent cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration" EXACT [GOC:curators] is_a: GO:0016477 ! cell migration [Term] id: GO:0006930 name: substrate-dependent cell migration, cell extension namespace: biological_process def: "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell extension" EXACT [GOC:curators] is_a: GO:0030031 ! cell projection assembly relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006931 name: substrate-dependent cell migration, cell attachment to substrate namespace: biological_process def: "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:curators] is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006932 name: substrate-dependent cell migration, cell contraction namespace: biological_process def: "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell contraction" EXACT [GOC:curators] is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0001667 ! ameboidal cell migration relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006933 name: negative regulation of cell adhesion involved in substrate-bound cell migration namespace: biological_process def: "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction." [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell release from substrate" EXACT [GOC:dph, GOC:tb] is_a: GO:0007162 ! negative regulation of cell adhesion relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006934 name: substrate-bound cell migration, adhesion receptor recycling namespace: biological_process def: "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions." [PMID:11944043] is_a: GO:0001881 ! receptor recycling relationship: part_of GO:0006933 ! negative regulation of cell adhesion involved in substrate-bound cell migration [Term] id: GO:0006935 name: chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "taxis in response to chemical stimulus" EXACT [] xref: Wikipedia:Chemotaxis is_a: GO:0042221 ! response to chemical stimulus is_a: GO:0042330 ! taxis [Term] id: GO:0006936 name: muscle contraction namespace: biological_process def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir xref: Reactome:1253025 "Smooth Muscle Contraction" xref: Reactome:1279954 "Smooth Muscle Contraction" xref: Reactome:1298847 "Smooth Muscle Contraction" xref: Reactome:1326530 "Smooth Muscle Contraction" xref: Reactome:1352639 "Smooth Muscle Contraction" xref: Reactome:1373559 "Smooth Muscle Contraction" xref: Reactome:1392877 "Smooth Muscle Contraction" xref: Reactome:1418082 "Smooth Muscle Contraction" xref: Reactome:1450447 "Smooth Muscle Contraction" xref: Reactome:1470972 "Smooth Muscle Contraction" xref: Reactome:1483008 "Smooth Muscle Contraction" xref: Reactome:1520996 "Smooth Muscle Contraction" xref: Reactome:445355 "Smooth Muscle Contraction" xref: Wikipedia:Muscle_contraction is_a: GO:0003012 ! muscle system process [Term] id: GO:0006937 name: regulation of muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] is_a: GO:0090257 ! regulation of muscle system process relationship: regulates GO:0006936 ! muscle contraction [Term] id: GO:0006939 name: smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "visceral muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction [Term] id: GO:0006940 name: regulation of smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction relationship: regulates GO:0006939 ! smooth muscle contraction [Term] id: GO:0006941 name: striated muscle contraction namespace: biological_process def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "sarcomeric muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction [Term] id: GO:0006942 name: regulation of striated muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction relationship: regulates GO:0006941 ! striated muscle contraction [Term] id: GO:0006943 name: chemi-mechanical coupling namespace: biological_process def: "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle)." [GOC:jid, http://www.m-w.com] comment: This term was made obsolete because its meaning is vague, and it does not fit with other terms in GO. synonym: "mechanochemical coupling" EXACT [] is_obsolete: true consider: GO:0009612 consider: GO:0050954 [Term] id: GO:0006944 name: cellular membrane fusion namespace: biological_process def: "The cellular process that joins two lipid bilayers to form a single membrane." [GOC:mah] xref: Wikipedia:Lipid_bilayer_fusion is_a: GO:0016044 ! cellular membrane organization is_a: GO:0061025 ! membrane fusion [Term] id: GO:0006945 name: nuclear fusion during karyogamy namespace: biological_process def: "OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process." [PMID:9442101] comment: This term was made obsolete because it is redundant outside the context of Saccharomyces biology. is_obsolete: true consider: GO:0000741 [Term] id: GO:0006948 name: induction by virus of host cell-cell fusion namespace: biological_process def: "The process of syncytia-forming cell-cell fusion, caused by a virus." [ISBN:0781718325] synonym: "induction by virus of cell-cell fusion in host" EXACT [] synonym: "viral-induced cell-cell fusion" EXACT [] synonym: "viral-induced host cell-cell fusion" EXACT [] synonym: "viral-induced membrane fusion" NARROW [] is_a: GO:0019048 ! virus-host interaction [Term] id: GO:0006949 name: syncytium formation namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir is_a: GO:0009987 ! cellular process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok subset: high_level_annotation_qc synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response namespace: biological_process alt_id: GO:0002217 alt_id: GO:0042829 def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] subset: gosubset_prok synonym: "antimicrobial peptide activity" RELATED [] synonym: "defence response" EXACT [] synonym: "defense/immunity protein activity" RELATED [] synonym: "physiological defense response" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0006953 name: acute-phase response namespace: biological_process def: "An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0006954 name: inflammatory response namespace: biological_process def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, GOC:mtg_15nov05, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was improved by GO_REF:0000022. It was moved. xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response is_a: GO:0009611 ! response to wounding [Term] id: GO:0006955 name: immune response namespace: biological_process def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was redefined and moved. is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006956 name: complement activation namespace: biological_process def: "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "complement activity" RELATED [] synonym: "complement cascade" EXACT [GOC:add] synonym: "complement response" EXACT [] xref: Reactome:1253355 "Initial triggering of complement" xref: Reactome:1253357 "Activation of C3 and C5" xref: Reactome:1280295 "Initial triggering of complement" xref: Reactome:1280297 "Activation of C3 and C5" xref: Reactome:1299146 "Initial triggering of complement" xref: Reactome:1299148 "Activation of C3 and C5" xref: Reactome:1326873 "Initial triggering of complement" xref: Reactome:1326875 "Activation of C3 and C5" xref: Reactome:1352965 "Initial triggering of complement" xref: Reactome:1373167 "Initial triggering of complement" xref: Reactome:1393205 "Initial triggering of complement" xref: Reactome:1417669 "Initial triggering of complement" xref: Reactome:1417671 "Activation of C3 and C5" xref: Reactome:1450771 "Initial triggering of complement" xref: Reactome:1450773 "Activation of C3 and C5" xref: Reactome:166663 "Initial triggering of complement" xref: Reactome:174577 "Activation of C3 and C5" is_a: GO:0002252 ! immune effector process is_a: GO:0002253 ! activation of immune response is_a: GO:0006959 ! humoral immune response is_a: GO:0072376 ! protein activation cascade [Term] id: GO:0006957 name: complement activation, alternative pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "complement cascade, alternative pathway" EXACT [GOC:add] xref: Reactome:1253389 "Alternative complement activation" xref: Reactome:1280328 "Alternative complement activation" xref: Reactome:1299177 "Alternative complement activation" xref: Reactome:1326906 "Alternative complement activation" xref: Reactome:1373194 "Alternative complement activation" xref: Reactome:1393208 "Alternative complement activation" xref: Reactome:1417703 "Alternative complement activation" xref: Reactome:1450803 "Alternative complement activation" xref: Reactome:173736 "Alternative complement activation" is_a: GO:0006956 ! complement activation is_a: GO:0045087 ! innate immune response [Term] id: GO:0006958 name: complement activation, classical pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "complement cascade, classical pathway" EXACT [GOC:add] xref: Reactome:1253386 "Classical antibody-mediated complement activation" xref: Reactome:1280326 "Classical antibody-mediated complement activation" xref: Reactome:1299175 "Classical antibody-mediated complement activation" xref: Reactome:1326904 "Classical antibody-mediated complement activation" xref: Reactome:1352996 "Classical antibody-mediated complement activation" xref: Reactome:1373192 "Classical antibody-mediated complement activation" xref: Reactome:1393203 "Classical antibody-mediated complement activation" xref: Reactome:1417700 "Classical antibody-mediated complement activation" xref: Reactome:173623 "Classical antibody-mediated complement activation" is_a: GO:0006956 ! complement activation relationship: part_of GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0006959 name: humoral immune response namespace: biological_process def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Humoral_immunity is_a: GO:0006955 ! immune response [Term] id: GO:0006962 name: male-specific antibacterial humoral response namespace: biological_process def: "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators] is_a: GO:0019731 ! antibacterial humoral response is_a: GO:0050831 ! male-specific defense response to bacterium [Term] id: GO:0006963 name: positive regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] synonym: "activation of antibacterial peptide biosynthetic process" NARROW [] synonym: "antibacterial peptide induction" EXACT [] synonym: "antibacterial polypeptide induction" EXACT [] synonym: "stimulation of antibacterial peptide biosynthetic process" NARROW [] synonym: "up regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "up-regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "upregulation of antibacterial peptide biosynthetic process" EXACT [] is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0006964 name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] synonym: "anti-Gram-negative bacterial peptide induction" EXACT [] synonym: "anti-Gram-negative bacterial polypeptide induction" EXACT [] synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process relationship: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0006965 name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] synonym: "anti-Gram-positive bacterial peptide induction" EXACT [] synonym: "anti-Gram-positive bacterial polypeptide induction" EXACT [] synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process relationship: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0006967 name: positive regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] synonym: "activation of antifungal peptide biosynthetic process" NARROW [] synonym: "antifungal peptide induction" EXACT [] synonym: "antifungal polypeptide induction" EXACT [] synonym: "stimulation of antifungal peptide biosynthetic process" NARROW [] synonym: "up regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "up-regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "upregulation of antifungal peptide biosynthetic process" EXACT [] is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process relationship: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0006968 name: cellular defense response namespace: biological_process alt_id: GO:0016066 alt_id: GO:0016067 def: "A defense response that is mediated by cells." [GOC:ebc] comment: Note that this term refers to any type of defense response made by any cell, whether only a single-celled organism or part of a multicellular organism; also includes responses that occur in the context of multiorganism processes. synonym: "cellular defence response" EXACT [] is_a: GO:0006952 ! defense response [Term] id: GO:0006969 name: melanotic tumor response namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it was undefined and represented an abnormal process. synonym: "melanotic mass response" EXACT [] is_obsolete: true [Term] id: GO:0006970 name: response to osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] subset: gosubset_prok synonym: "osmotic response" EXACT [] synonym: "osmotic stress response" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0006971 name: hypotonic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, PMID:12598593] synonym: "hypo-osmotic response" EXACT [] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0006972 name: hyperosmotic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, PMID:12142009] synonym: "HOG response" EXACT [] synonym: "hypertonic response" EXACT [] synonym: "response to hypertonicity" EXACT [GOC:mah, GOC:yaf] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0006973 name: intracellular accumulation of glycerol namespace: biological_process def: "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment." [GOC:jl, PMID:11752666] is_a: GO:0019725 ! cellular homeostasis relationship: part_of GO:0071474 ! cellular hyperosmotic response [Term] id: GO:0006974 name: response to DNA damage stimulus namespace: biological_process alt_id: GO:0034984 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] subset: gosubset_prok synonym: "cellular DNA damage response" EXACT [] synonym: "cellular response to DNA damage stimulus" EXACT [] synonym: "DNA damage response" EXACT [] synonym: "response to genotoxic stress" EXACT [] is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0006975 name: DNA damage induced protein phosphorylation namespace: biological_process def: "The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006468 ! protein phosphorylation is_a: GO:0006974 ! response to DNA damage stimulus [Term] id: GO:0006977 name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators] synonym: "positive regulation of cell cycle arrest by p53-mediated DNA damage response" EXACT [GOC:dph, GOC:mah] xref: Reactome:1252902 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1279836 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1298754 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1326405 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1352521 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1372749 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1392759 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1417236 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1450324 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1497010 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1514397 "p53-Dependent G1 DNA Damage Response" xref: Reactome:1521269 "p53-Dependent G1 DNA Damage Response" xref: Reactome:69563 "p53-Dependent G1 DNA Damage Response" is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator is_a: GO:0071158 ! positive regulation of cell cycle arrest is_a: GO:0072431 ! signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint [Term] id: GO:0006978 name: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424] is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator is_a: GO:0042772 ! DNA damage response, signal transduction resulting in transcription [Term] id: GO:0006979 name: response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] subset: gosubset_prok is_a: GO:0006950 ! response to stress is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0006981 name: activation of SoxR protein namespace: biological_process def: "The conversion of the SoxR transcription factor to its active (oxidized) form." [GOC:jl, PMID:8816757] subset: gosubset_prok is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:0071461 ! cellular response to redox state [Term] id: GO:0006982 name: response to lipid hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:jl, PMID:10944149] subset: gosubset_prok synonym: "response to LHPO" EXACT [] is_a: GO:0033194 ! response to hydroperoxide [Term] id: GO:0006983 name: ER overload response namespace: biological_process def: "The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516] synonym: "endoplasmic reticulum overload response" EXACT [] synonym: "EOR" EXACT [] synonym: "ER-overload response" EXACT [] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0071216 ! cellular response to biotic stimulus [Term] id: GO:0006984 name: ER-nucleus signaling pathway namespace: biological_process def: "Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah] synonym: "endoplasmic reticulum to nucleus signaling pathway" EXACT [] synonym: "endoplasmic reticulum-nuclear signaling pathway" EXACT [] synonym: "ER to nucleus signaling pathway" EXACT [] synonym: "ER to nucleus signalling pathway" EXACT [] synonym: "ER-nuclear signaling pathway" EXACT [] synonym: "ER-nuclear signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0006985 name: positive regulation of NF-kappaB transcription factor activity by ER overload response namespace: biological_process def: "The conversion of inactive NF-kappaB to the active form, thereby allowing it to activate transcription of target genes, as a result of signaling from the endoplasmic reticulum." [GOC:dph, GOC:mah, GOC:tb, PMID:10390516] synonym: "EOR-mediated activation of NF-kappaB " EXACT [GOC:dph, GOC:tb] synonym: "EOR-mediated NF-kappaB activation" EXACT [] synonym: "positive regulation of NF-kappaB transcription factor activity by EOR" EXACT [GOC:dph, GOC:tb] is_a: GO:0051092 ! positive regulation of NF-kappaB transcription factor activity relationship: part_of GO:0006983 ! ER overload response [Term] id: GO:0006986 name: response to unfolded protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER. subset: gosubset_prok synonym: "heat shock protein activity" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051789 ! response to protein stimulus [Term] id: GO:0006987 name: activation of signaling protein activity involved in unfolded protein response namespace: biological_process def: "The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763] synonym: "unfolded protein response, activation of signaling protein activity" EXACT [GOC:dph, GOC:tb] synonym: "unfolded protein response, activation of signaling protein kinase/endonuclease" EXACT [] synonym: "unfolded protein response, activation of signalling protein kinase/endonuclease" EXACT [] is_a: GO:0032075 ! positive regulation of nuclease activity is_a: GO:0045860 ! positive regulation of protein kinase activity relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response [Term] id: GO:0006988 name: unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0004521 consider: GO:0030969 [Term] id: GO:0006989 name: unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0008452 consider: GO:0030969 [Term] id: GO:0006990 name: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response namespace: biological_process def: "The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763] synonym: "positive regulation of transcription of target genes involved in unfolded protein response" EXACT [GOC:dph, GOC:tb] synonym: "unfolded protein response, activation of target gene transcription" NARROW [] synonym: "unfolded protein response, positive regulation of target gene transcription" EXACT [GOC:tb] synonym: "unfolded protein response, stimulation of target gene transcription" NARROW [] synonym: "unfolded protein response, target gene transcriptional activation" BROAD [] synonym: "unfolded protein response, up regulation of target gene transcription" EXACT [] synonym: "unfolded protein response, up-regulation of target gene transcription" EXACT [] synonym: "unfolded protein response, upregulation of target gene transcription" EXACT [] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response [Term] id: GO:0006991 name: response to sterol depletion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "sterol depletion response" EXACT [GOC:dph, GOC:tb] is_a: GO:0006950 ! response to stress [Term] id: GO:0006992 name: sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway namespace: biological_process def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to depleted sterol levels." [GOC:bf, PMID:12923525] synonym: "sterol depletion response, SREBP cleavage" EXACT [] is_a: GO:0035103 ! sterol regulatory element binding protein cleavage relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway [Term] id: GO:0006993 name: sterol regulatory element binding protein import into nucleus involved in sterol depletion response namespace: biological_process def: "The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus across the nuclear membrane, in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] synonym: "SREBP import into nucleus involved in sterol depletion response" EXACT [GOC:mah] synonym: "sterol depletion response, SREBP import into nucleus" EXACT [GOC:mah] synonym: "sterol depletion response, SREBP nuclear translocation" NARROW [GOC:mah] synonym: "sterol depletion response, sterol regulatory element binding protein import into nucleus" EXACT [] synonym: "sterol depletion response, sterol regulatory element binding protein nuclear translocation" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "sterol regulatory element binding protein nuclear translocation involved in sterol depletion response" NARROW [GOC:mah] is_a: GO:0035105 ! sterol regulatory element binding protein import into nucleus relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway [Term] id: GO:0006994 name: positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway namespace: biological_process def: "The process in which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] synonym: "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response" EXACT [GOC:dph, GOC:tb] synonym: "sterol depletion response, SREBP target gene transcriptional activation" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0035104 ! positive regulation of transcription via sterol regulatory element binding relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway [Term] id: GO:0006995 name: cellular response to nitrogen starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl] subset: gosubset_prok is_a: GO:0009267 ! cellular response to starvation is_a: GO:0043562 ! cellular response to nitrogen levels [Term] id: GO:0006996 name: organelle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_candida subset: goslim_pir subset: gosubset_prok synonym: "organelle organisation" EXACT [GOC:curators] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [GOC:curators] synonym: "nuclear organization" EXACT [GOC:curators] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0006998 name: nuclear envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] synonym: "nuclear envelope organisation" EXACT [GOC:mah] synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0006997 ! nucleus organization [Term] id: GO:0006999 name: nuclear pore organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nuclear pore complex organization and biogenesis" RELATED [GOC:mah] synonym: "nuclear pore organisation" EXACT [GOC:curators] synonym: "nuclear pore organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization is_a: GO:0034621 ! cellular macromolecular complex subunit organization [Term] id: GO:0007000 name: nucleolus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nucleolus organisation" EXACT [GOC:curators] synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0007002 name: centromere binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0019237 [Term] id: GO:0007003 name: telomere binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0042162 [Term] id: GO:0007004 name: telomere maintenance via telomerase namespace: biological_process def: "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] synonym: "telomerase-dependent telomere maintenance" EXACT [] xref: Reactome:1233174 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1233175 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1233176 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1233178 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1233608 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1233609 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1253321 "Telomere Extension By Telomerase" xref: Reactome:1260858 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1260859 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1260860 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1260862 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1261316 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1261317 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1280259 "Telomere Extension By Telomerase" xref: Reactome:1285865 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1285866 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1285867 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1285869 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1286214 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1286215 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1299116 "Telomere Extension By Telomerase" xref: Reactome:1306764 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1306765 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1306766 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1306768 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1307232 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1307233 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1326837 "Telomere Extension By Telomerase" xref: Reactome:1358574 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1358575 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1358576 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1358578 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1358964 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1358965 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1373137 "Telomere Extension By Telomerase" xref: Reactome:1379576 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1379577 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1379578 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1379580 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1379825 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1379826 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1393153 "Telomere Extension By Telomerase" xref: Reactome:1427698 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1427699 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1427700 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1427702 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1428167 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1428168 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1450739 "Telomere Extension By Telomerase" xref: Reactome:1489315 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1489316 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1489317 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1489319 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1489395 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1489396 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1496877 "Telomere Extension By Telomerase" xref: Reactome:1504193 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1504194 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1504195 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1504197 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1504321 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1504322 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1514270 "Telomere Extension By Telomerase" xref: Reactome:1517729 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1517730 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1517731 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1517733 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1517820 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1517821 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1521127 "Telomere Extension By Telomerase" xref: Reactome:1524360 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1524361 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1524362 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1524364 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1524424 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1524425 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1526887 "Telomere Extension By Telomerase" xref: Reactome:1530203 "Elongation Of The Telomeric Chromosome End" xref: Reactome:1530204 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:1530205 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:1530207 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:1530249 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:1530250 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:1532616 "Telomere Extension By Telomerase" xref: Reactome:163090 "Elongation Of The Telomeric Chromosome End" xref: Reactome:163096 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:163099 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:163120 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:164616 "Biogenesis And Assembly Of The Telomerase RNP" xref: Reactome:164617 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:164620 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:171319 "Telomere Extension By Telomerase" is_a: GO:0006278 ! RNA-dependent DNA replication is_a: GO:0010833 ! telomere maintenance via telomere lengthening [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [GOC:curators] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007006 name: mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "mitochondrial membrane organisation" EXACT [GOC:curators] synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0007007 name: inner mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "inner mitochondrial membrane organisation" EXACT [GOC:curators] synonym: "inner mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] synonym: "mitochondrial inner membrane organization" EXACT [GOC:curators] is_a: GO:0007006 ! mitochondrial membrane organization [Term] id: GO:0007008 name: outer mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. synonym: "outer mitochondrial membrane organisation" EXACT [GOC:curators] synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007006 ! mitochondrial membrane organization [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "plasma membrane organisation" EXACT [GOC:curators] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [GOC:curators] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007011 name: regulation of cytoskeleton namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] comment: This term was made obsolete because cytoskeleton is neither a process nor a trait, so the term made no sense. is_obsolete: true consider: GO:0007010 [Term] id: GO:0007014 name: actin ubiquitination namespace: biological_process def: "The modification of actin by addition of ubiquitin groups." [GOC:mah] synonym: "indirect flight muscle actin ubiquitination" NARROW [GOC:mah] is_a: GO:0016567 ! protein ubiquitination is_a: GO:0030047 ! actin modification [Term] id: GO:0007015 name: actin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] synonym: "actin filament organisation" EXACT [GOC:curators] synonym: "regulation of actin filament localization" NARROW [] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0007016 name: cytoskeletal anchoring at plasma membrane namespace: biological_process def: "A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] synonym: "cytoskeletal anchoring activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0032507 ! maintenance of protein location in cell [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] is_a: GO:0009987 ! cellular process [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [ISBN:0815316194] xref: Reactome:1236046 "Axonal transport of NGF:Trk complexes" xref: Reactome:1263348 "Axonal transport of NGF:Trk complexes" xref: Reactome:1287881 "Axonal transport of NGF:Trk complexes" xref: Reactome:1309734 "Axonal transport of NGF:Trk complexes" xref: Reactome:1336646 "Axonal transport of NGF:Trk complexes" xref: Reactome:1360588 "Axonal transport of NGF:Trk complexes" xref: Reactome:1381335 "Axonal transport of NGF:Trk complexes" xref: Reactome:1402614 "Axonal transport of NGF:Trk complexes" xref: Reactome:1430730 "Axonal transport of NGF:Trk complexes" xref: Reactome:1459236 "Axonal transport of NGF:Trk complexes" xref: Reactome:177479 "Axonal transport of NGF:Trk complexes" xref: Reactome:983189 "Kinesins" is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0007019 name: microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "microtubule depolymerization during nuclear congression" NARROW [] synonym: "microtubule disassembly" EXACT [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization [Term] id: GO:0007020 name: microtubule nucleation namespace: biological_process def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [ISBN:0815316194] xref: Wikipedia:Microtubule_nucleation is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0007021 name: tubulin complex assembly namespace: biological_process def: "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah] synonym: "tubulin assembly" EXACT [] synonym: "tubulin folding" RELATED [] synonym: "tubulin-specific chaperone activity" RELATED [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0072668 ! tubulin complex biogenesis [Term] id: GO:0007023 name: post-chaperonin tubulin folding pathway namespace: biological_process def: "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094] xref: Reactome:1253680 "Post-chaperonin tubulin folding pathway" xref: Reactome:1280612 "Post-chaperonin tubulin folding pathway" xref: Reactome:1299443 "Post-chaperonin tubulin folding pathway" xref: Reactome:1327197 "Post-chaperonin tubulin folding pathway" xref: Reactome:1353292 "Post-chaperonin tubulin folding pathway" xref: Reactome:1373469 "Post-chaperonin tubulin folding pathway" xref: Reactome:1393490 "Post-chaperonin tubulin folding pathway" xref: Reactome:1417990 "Post-chaperonin tubulin folding pathway" xref: Reactome:1451077 "Post-chaperonin tubulin folding pathway" xref: Reactome:1471435 "Post-chaperonin tubulin folding pathway" xref: Reactome:1527008 "Post-chaperonin tubulin folding pathway" xref: Reactome:1532745 "Post-chaperonin tubulin folding pathway" xref: Reactome:389977 "Post-chaperonin tubulin folding pathway" xref: Reactome:391548 "Post-chaperonin tubulin folding pathway" is_a: GO:0006457 ! protein folding relationship: part_of GO:0072668 ! tubulin complex biogenesis [Term] id: GO:0007026 name: negative regulation of microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] synonym: "down regulation of microtubule depolymerization" EXACT [] synonym: "down-regulation of microtubule depolymerization" EXACT [] synonym: "downregulation of microtubule depolymerization" EXACT [] synonym: "inhibition of microtubule depolymerization" NARROW [] synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb] synonym: "microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of microtubule disassembly" EXACT [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:0043242 ! negative regulation of protein complex disassembly relationship: negatively_regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0007027 name: negative regulation of axonemal microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah] synonym: "axonemal microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph] is_a: GO:0007026 ! negative regulation of microtubule depolymerization relationship: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization [Term] id: GO:0007028 name: cytoplasm organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "cytoplasm organisation" EXACT [GOC:curators] synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0007029 name: endoplasmic reticulum organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "endoplasmic reticulum morphology" RELATED [] synonym: "endoplasmic reticulum organisation" EXACT [GOC:curators] synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah] synonym: "ER organisation" EXACT [GOC:curators] synonym: "ER organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007030 name: Golgi organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "Golgi organisation" EXACT [GOC:curators] synonym: "Golgi organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007031 name: peroxisome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "peroxisome organisation" EXACT [GOC:curators] synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah] synonym: "peroxisome-assembly ATPase activity" RELATED [] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007032 name: endosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "endosome organisation" EXACT [GOC:curators] synonym: "endosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007033 name: vacuole organization namespace: biological_process alt_id: GO:0044086 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [GOC:curators] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_generic is_a: GO:0046907 ! intracellular transport [Term] id: GO:0007035 name: vacuolar acidification namespace: biological_process def: "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid] is_a: GO:0051452 ! intracellular pH reduction [Term] id: GO:0007036 name: vacuolar calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0007037 name: vacuolar phosphate transport namespace: biological_process def: "The directed movement of phosphates into, out of or within a vacuole." [GOC:ai] is_a: GO:0006817 ! phosphate transport is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0007038 name: endocytosed protein transport to vacuole namespace: biological_process def: "The directed movement of proteins imported into a cell by endocytosis to the vacuole." [GOC:ai] comment: See also the biological process term 'endocytosis ; GO:0006897'. synonym: "delivery of endocytosed proteins to the vacuole" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0007039 name: vacuolar protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah] synonym: "vacuolar protein breakdown" EXACT [] synonym: "vacuolar protein catabolism" EXACT [] synonym: "vacuolar protein degradation" EXACT [] is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0007040 name: lysosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] synonym: "lysosome organisation" EXACT [GOC:curators] synonym: "lysosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007033 ! vacuole organization [Term] id: GO:0007041 name: lysosomal transport namespace: biological_process def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai] is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0007042 name: lysosomal lumen acidification namespace: biological_process def: "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid] synonym: "lysosome pH reduction" EXACT [GOC:bf, GOC:rph] is_a: GO:0035751 ! regulation of lysosomal lumen pH is_a: GO:0051452 ! intracellular pH reduction [Term] id: GO:0007043 name: cell-cell junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] synonym: "intercellular junction assembly" EXACT [] is_a: GO:0034329 ! cell junction assembly is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0007044 name: cell-substrate junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] is_a: GO:0034329 ! cell junction assembly [Term] id: GO:0007045 name: cell-substrate adherens junction assembly namespace: biological_process def: "The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction." [GOC:mah] synonym: "hemi-adherens junction assembly" RELATED [GOC:mah] is_a: GO:0007044 ! cell-substrate junction assembly [Term] id: GO:0007047 name: cellular cell wall organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:jl, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_pir subset: gosubset_prok synonym: "cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "cell wall organization at cellular level" EXACT [GOC:mah] synonym: "cellular cell wall organisation" EXACT [GOC:curators] is_a: GO:0045229 ! external encapsulating structure organization is_a: GO:0070882 ! cellular cell wall organization or biogenesis is_a: GO:0071555 ! cell wall organization [Term] id: GO:0007048 name: oncogenesis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a pathological process. is_obsolete: true [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "cell-division cycle" EXACT [] xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007050 name: cell cycle arrest namespace: biological_process def: "A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb] synonym: "arrest of cell cycle progression" EXACT [] synonym: "cessation of cell cycle" EXACT [] synonym: "termination of cell cycle" EXACT [] xref: Reactome:1253534 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1280473 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1299294 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1327051 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1353145 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1373324 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1393348 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1417842 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1450933 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1471320 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1483292 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1497038 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1514425 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1521287 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1526992 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:1532731 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:380972 "Energy dependent regulation of mTOR by LKB1-AMPK" is_a: GO:0022402 ! cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle [Term] id: GO:0007051 name: spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah] synonym: "spindle organisation" EXACT [GOC:curators] synonym: "spindle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0000279 ! M phase [Term] id: GO:0007052 name: mitotic spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] synonym: "mitotic spindle organisation" EXACT [GOC:curators] synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle organization and biogenesis during mitosis" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007053 name: spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] is_a: GO:0090306 ! spindle assembly involved in meiosis relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007054 name: spindle assembly involved in male meiosis I namespace: biological_process def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "male meiosis I spindle assembly" RELATED [] is_a: GO:0007053 ! spindle assembly involved in male meiosis relationship: part_of GO:0007141 ! male meiosis I [Term] id: GO:0007055 name: spindle assembly involved in male meiosis II namespace: biological_process def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "male meiosis II spindle assembly" RELATED [] is_a: GO:0007053 ! spindle assembly involved in male meiosis relationship: part_of GO:0007142 ! male meiosis II [Term] id: GO:0007056 name: spindle assembly involved in female meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiotic spindle assembly" RELATED [] is_a: GO:0090306 ! spindle assembly involved in meiosis relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0007057 name: spindle assembly involved in female meiosis I namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiosis I spindle assembly" RELATED [] is_a: GO:0007056 ! spindle assembly involved in female meiosis relationship: part_of GO:0007144 ! female meiosis I [Term] id: GO:0007058 name: spindle assembly involved in female meiosis II namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiosis II spindle assembly" RELATED [] is_a: GO:0007056 ! spindle assembly involved in female meiosis relationship: part_of GO:0007147 ! female meiosis II [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:ai, GOC:mah] subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0009987 ! cellular process [Term] id: GO:0007060 name: male meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007062 name: sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome." [GOC:mah, ISBN:0815316194] xref: Reactome:1233149 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:1260840 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:1306752 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:1334289 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:1400114 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:1427670 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:1457708 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:1475922 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:1517708 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:163048 "Phosphorylation of the SA2 Cohesion Complex" is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0007059 ! chromosome segregation [Term] id: GO:0007063 name: regulation of sister chromatid cohesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation relationship: regulates GO:0007062 ! sister chromatid cohesion [Term] id: GO:0007064 name: mitotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] is_a: GO:0007062 ! sister chromatid cohesion relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007065 name: male meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai] is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007066 name: female meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai] is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0007067 name: mitosis namespace: biological_process def: "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] subset: goslim_generic xref: Wikipedia:Mitosis is_a: GO:0000280 ! nuclear division is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000087 ! M phase of mitotic cell cycle [Term] id: GO:0007068 name: negative regulation of transcription during mitosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] synonym: "down regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription" EXACT [] synonym: "negative regulation of transcription, mitotic" EXACT [GOC:mah] is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent is_a: GO:0045896 ! regulation of transcription during mitosis [Term] id: GO:0007069 name: negative regulation of transcription from RNA polymerase I promoter during mitosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription from Pol I promoter" EXACT [] synonym: "negative regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah] is_a: GO:0007068 ! negative regulation of transcription during mitosis is_a: GO:0016479 ! negative regulation of transcription from RNA polymerase I promoter is_a: GO:0046017 ! regulation of transcription from RNA polymerase I promoter, mitotic [Term] id: GO:0007070 name: negative regulation of transcription from RNA polymerase II promoter during mitosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0007068 ! negative regulation of transcription during mitosis is_a: GO:0046021 ! regulation of transcription from RNA polymerase II promoter, mitotic [Term] id: GO:0007071 name: negative regulation of transcription from RNA polymerase III promoter during mitosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription from Pol III promoter" EXACT [] synonym: "negative regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah] is_a: GO:0007068 ! negative regulation of transcription during mitosis is_a: GO:0016480 ! negative regulation of transcription from RNA polymerase III promoter is_a: GO:0046023 ! regulation of transcription from RNA polymerase III promoter, mitotic [Term] id: GO:0007072 name: positive regulation of transcription on exit from mitosis namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent relationship: part_of GO:0010458 ! exit from mitosis [Term] id: GO:0007073 name: positive regulation of transcription on exit from mitosis, from RNA polymerase I promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW [] is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis [Term] id: GO:0007074 name: positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW [] is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis [Term] id: GO:0007075 name: positive regulation of transcription on exit from mitosis, from RNA polymerase III promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb] is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis [Term] id: GO:0007076 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] is_a: GO:0022402 ! cell cycle process is_a: GO:0030261 ! chromosome condensation relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007077 name: mitotic nuclear envelope disassembly namespace: biological_process def: "The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf] synonym: "mitotic nuclear envelope breakdown" EXACT [] synonym: "mitotic nuclear envelope catabolism" EXACT [] synonym: "mitotic nuclear envelope degradation" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051081 ! nuclear envelope disassembly relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007078 name: lamin depolymerization namespace: biological_process def: "The cell cycle process in which lamin is depolymerized." [GOC:jid] is_a: GO:0022402 ! cell cycle process is_a: GO:0051261 ! protein depolymerization relationship: part_of GO:0007077 ! mitotic nuclear envelope disassembly [Term] id: GO:0007079 name: mitotic chromosome movement towards spindle pole namespace: biological_process alt_id: GO:0007082 def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai] synonym: "chromosome migration to spindle pole during mitosis" EXACT [] synonym: "chromosome movement towards spindle pole during mitosis" EXACT [] synonym: "mitotic chromosome movement" BROAD [] synonym: "mitotic chromosome movement to spindle pole" EXACT [] synonym: "mitotic sister chromosome movement towards spindle pole" EXACT [] synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051305 ! chromosome movement towards spindle pole relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007080 name: mitotic metaphase plate congression namespace: biological_process def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194] is_a: GO:0022402 ! cell cycle process is_a: GO:0051310 ! metaphase plate congression relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007081 name: mitotic sister-chromatid adhesion release namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term name is ambiguous and appears to encompass two processes. is_obsolete: true consider: GO:0000070 consider: GO:0007064 [Term] id: GO:0007083 name: mitotic chromosome decondensation namespace: biological_process def: "The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0051312 ! chromosome decondensation relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007084 name: mitotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process that results in reformation of the nuclear envelope during mitotic cell division." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0031468 ! nuclear envelope reassembly relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007085 name: nuclear membrane vesicle binding to chromatin namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true consider: GO:0003682 [Term] id: GO:0007086 name: vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly." [GOC:jid, GOC:mah] is_a: GO:0006906 ! vesicle fusion is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly [Term] id: GO:0007087 name: mitotic nuclear pore complex reassembly namespace: biological_process def: "The cell cycle process in which nuclear pore complexes reform during mitotic cell division." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0051292 ! nuclear pore complex assembly relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly [Term] id: GO:0007088 name: regulation of mitosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division relationship: regulates GO:0007067 ! mitosis [Term] id: GO:0007089 name: traversing start control point of mitotic cell cycle namespace: biological_process alt_id: GO:0000081 def: "Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle." [GOC:mah, ISBN:0815316194] synonym: "G1 checkpoint" RELATED [] is_a: GO:0007346 ! regulation of mitotic cell cycle relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle [Term] id: GO:0007090 name: regulation of S phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators] synonym: "regulation of S-phase of mitotic cell cycle" EXACT [] is_a: GO:0033261 ! regulation of S phase is_a: GO:2000602 ! regulation of interphase of mitotic cell cycle relationship: regulates GO:0000084 ! S phase of mitotic cell cycle [Term] id: GO:0007091 name: mitotic metaphase/anaphase transition namespace: biological_process def: "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins." [PMID:10465783] xref: Reactome:1253319 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1280257 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1326835 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1352932 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1373136 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1393152 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1417640 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1450737 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1471182 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1483174 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:1521125 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:68881 "Mitotic Metaphase/Anaphase Transition" is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0007092 name: activation of mitotic anaphase-promoting complex activity namespace: biological_process def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex that regulates the mitotic metaphase/anaphase transition." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297] synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during mitotic cell cycle" EXACT [] synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during mitotic cell cycle" EXACT [] synonym: "activation of ubiquitin ligase activity of APC during mitotic cell cycle" EXACT [] synonym: "anaphase promoting complex activation during mitotic cell cycle" EXACT [] synonym: "anaphase-promoting complex activation during mitotic cell cycle" EXACT [] synonym: "APC activation during mitotic cell cycle" EXACT [] synonym: "mitotic anaphase promoting complex activation" EXACT [] synonym: "mitotic anaphase promoting complex activator" NARROW [] synonym: "mitotic anaphase-promoting complex activation" EXACT [] synonym: "mitotic anaphase-promoting complex activator" NARROW [] synonym: "mitotic APC activation" EXACT [] synonym: "mitotic APC activator" NARROW [] xref: Reactome:1232994 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1233125 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:1260816 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:1306613 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1306728 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:1334131 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1334250 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:1358376 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1358453 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:1379481 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1379551 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:1400023 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1400090 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:1427461 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1427614 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:1457571 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1475849 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1517592 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1524315 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:1530134 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:162659 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:163010 "Down Regulation of Emi1 through Phosphorylation of Emi1" is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition is_a: GO:0051437 ! positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle is_a: GO:0051488 ! activation of anaphase-promoting complex activity relationship: positively_regulates GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0007093 name: mitotic cell cycle checkpoint namespace: biological_process def: "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, GOC:rn, PMID:12360190] synonym: "mitotic checkpoint" RELATED [] synonym: "regulation of mitotic cell cycle by cell cycle checkpoint" EXACT [GOC:dph, GOC:tb] is_a: GO:0000075 ! cell cycle checkpoint is_a: GO:0007346 ! regulation of mitotic cell cycle [Term] id: GO:0007094 name: mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:curators, GOC:rn, PMID:12360190] synonym: "Mad2-dependent checkpoint" NARROW [] synonym: "negative regulation of mitotic metaphase/anaphase transition by spindle assembly checkpoint" EXACT [GOC:dph, GOC:tb] xref: Reactome:1253268 "Mitotic Spindle Checkpoint" xref: Reactome:1280206 "Mitotic Spindle Checkpoint" xref: Reactome:1299076 "Mitotic Spindle Checkpoint" xref: Reactome:1326780 "Mitotic Spindle Checkpoint" xref: Reactome:1352884 "Mitotic Spindle Checkpoint" xref: Reactome:1373090 "Mitotic Spindle Checkpoint" xref: Reactome:1393105 "Mitotic Spindle Checkpoint" xref: Reactome:1417591 "Mitotic Spindle Checkpoint" xref: Reactome:1450682 "Mitotic Spindle Checkpoint" xref: Reactome:1471146 "Mitotic Spindle Checkpoint" xref: Reactome:1483151 "Mitotic Spindle Checkpoint" xref: Reactome:1496868 "Mitotic Spindle Checkpoint" xref: Reactome:1514261 "Mitotic Spindle Checkpoint" xref: Reactome:1521101 "Mitotic Spindle Checkpoint" xref: Reactome:1532600 "Mitotic Spindle Checkpoint" xref: Reactome:69618 "Mitotic Spindle Checkpoint" is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition is_a: GO:0071173 ! spindle assembly checkpoint is_a: GO:0071174 ! mitotic cell cycle spindle checkpoint [Term] id: GO:0007095 name: mitotic cell cycle G2/M transition DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage." [GOC:mah, PMID:10856933, PMID:11406266] synonym: "mitotic G2 checkpoint" RELATED [] is_a: GO:0031572 ! G2/M transition DNA damage checkpoint is_a: GO:0071780 ! mitotic cell cycle G2/M transition checkpoint [Term] id: GO:0007096 name: regulation of exit from mitosis namespace: biological_process def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process relationship: regulates GO:0010458 ! exit from mitosis [Term] id: GO:0007097 name: nuclear migration namespace: biological_process def: "The directed movement of the nucleus." [GOC:ai] synonym: "nucleus migration" EXACT [] is_a: GO:0040023 ! establishment of nucleus localization [Term] id: GO:0007098 name: centrosome cycle namespace: biological_process def: "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] is_a: GO:0022402 ! cell cycle process is_a: GO:0051297 ! centrosome organization [Term] id: GO:0007099 name: centriole replication namespace: biological_process def: "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] synonym: "centriole duplication" EXACT [] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051298 ! centrosome duplication [Term] id: GO:0007100 name: mitotic centrosome separation namespace: biological_process def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] is_a: GO:0051299 ! centrosome separation relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0007101 name: male meiosis centrosome cycle namespace: biological_process def: "Centrosome duplication and separation in the context of a meiotic cell cycle in a male organism." [GOC:mah] synonym: "centrosome cycle involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0007098 ! centrosome cycle relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0007103 name: spindle pole body duplication in nuclear envelope namespace: biological_process def: "Construction of a new spindle pole body adjacent to the existing spindle pole body in the nuclear envelope; usually occurs about the time of bud emergence. An example of this is found in Saccharomyces cerevisiae." [ISBN:0879693649] is_a: GO:0030474 ! spindle pole body duplication [Term] id: GO:0007105 name: cytokinesis, site selection namespace: biological_process def: "The process of marking the place where cytokinesis will occur." [GOC:clt, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "site selection involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0007106 name: cytokinesis, protein recruitment namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined. is_obsolete: true [Term] id: GO:0007107 name: membrane addition at site of cytokinesis namespace: biological_process def: "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:clt] synonym: "cytokinesis, membrane recruitment/generation" EXACT [] is_a: GO:0016044 ! cellular membrane organization is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0007108 name: cytokinesis, initiation of separation namespace: biological_process def: "The process involved in starting cell separation." [GOC:clt, GOC:dph, GOC:tb] synonym: "initiation of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000920 ! cytokinetic cell separation [Term] id: GO:0007109 name: cytokinesis, completion of separation namespace: biological_process def: "The process of finishing cell separation, which results in two physically separated cells." [GOC:clt, GOC:dph, GOC:tb] synonym: "completion of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000920 ! cytokinetic cell separation [Term] id: GO:0007110 name: cytokinesis after meiosis I namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:ai] is_a: GO:0033206 ! cytokinesis after meiosis [Term] id: GO:0007111 name: cytokinesis after meiosis II namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:ai] is_a: GO:0033206 ! cytokinesis after meiosis [Term] id: GO:0007112 name: male meiosis cytokinesis namespace: biological_process def: "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] synonym: "cytokinesis after male meiosis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinesis involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0033206 ! cytokinesis after meiosis [Term] id: GO:0007113 name: endomitotic cell cycle namespace: biological_process def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. synonym: "endomitosis" RELATED [] xref: Wikipedia:Mitosis#Endomitosis is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0007114 name: cell budding namespace: biological_process def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "budding" BROAD [] is_a: GO:0019954 ! asexual reproduction is_a: GO:0032505 ! reproduction of a single-celled organism is_a: GO:0051301 ! cell division [Term] id: GO:0007115 name: bud site selection/establishment of cell polarity (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents two processes. is_obsolete: true consider: GO:0000282 consider: GO:0030010 [Term] id: GO:0007116 name: regulation of cell budding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds." [GOC:mah] synonym: "regulation of budding" BROAD [] is_a: GO:0051302 ! regulation of cell division relationship: regulates GO:0007114 ! cell budding [Term] id: GO:0007117 name: budding cell bud growth namespace: biological_process def: "The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:go_curators] synonym: "bud growth" BROAD [] is_a: GO:0040007 ! growth relationship: part_of GO:0007114 ! cell budding [Term] id: GO:0007118 name: budding cell apical bud growth namespace: biological_process def: "Growth at the tip of a bud, in a cell that reproduces by budding." [GOC:go_curators] synonym: "apical bud growth" BROAD [] is_a: GO:0007117 ! budding cell bud growth [Term] id: GO:0007119 name: budding cell isotropic bud growth namespace: biological_process def: "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding." [GOC:go_curators] synonym: "isotropic bud growth" BROAD [] is_a: GO:0007117 ! budding cell bud growth [Term] id: GO:0007120 name: axial cellular bud site selection namespace: biological_process def: "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell." [GOC:clt] synonym: "axial bud site selection" EXACT [] synonym: "axial budding" BROAD [] is_a: GO:0000282 ! cellular bud site selection is_a: GO:0007114 ! cell budding [Term] id: GO:0007121 name: bipolar cellular bud site selection namespace: biological_process def: "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell." [GOC:clt] synonym: "bipolar bud site selection" EXACT [] synonym: "bipolar budding" BROAD [] synonym: "polar budding" BROAD [] is_a: GO:0000282 ! cellular bud site selection is_a: GO:0007114 ! cell budding [Term] id: GO:0007122 name: loss of asymmetric budding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a phenotype rather than a biological process. is_obsolete: true consider: GO:0006033 [Term] id: GO:0007123 name: bud scar accumulation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a phenotype rather than a biological process. is_obsolete: true consider: GO:0000282 [Term] id: GO:0007124 name: pseudohyphal growth namespace: biological_process def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818] subset: goslim_candida subset: goslim_yeast is_a: GO:0016049 ! cell growth is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0007125 name: invasive growth namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it has been split into two new terms. is_obsolete: true consider: GO:0001403 consider: GO:0044409 [Term] id: GO:0007126 name: meiosis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations." [GOC:dph, GOC:mah, PMID:9334324] subset: goslim_pombe subset: goslim_yeast xref: Wikipedia:Meiosis is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051327 ! M phase of meiotic cell cycle [Term] id: GO:0007127 name: meiosis I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:mah, PMID:9334324] xref: Wikipedia:Meiosis#Meiosis_I is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0007128 name: meiotic prophase I namespace: biological_process def: "Prophase occurring as part of meiosis I. Prophase is the part of nuclear division in which, canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. Meiosis I is the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other." [GOC:dph, GOC:mah] is_a: GO:0051324 ! prophase relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007129 name: synapsis namespace: biological_process def: "The cell cycle process in which the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate." [GOC:elh] synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "chromosomal synapsis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "homologous chromosome pairing at meiosis" EXACT [] xref: Wikipedia:Synapsis is_a: GO:0070192 ! chromosome organization involved in meiosis relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007130 name: synaptonemal complex assembly namespace: biological_process def: "The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "synaptonemal complex formation" EXACT [] is_a: GO:0070192 ! chromosome organization involved in meiosis is_a: GO:0070193 ! synaptonemal complex organization is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0007131 name: reciprocal meiotic recombination namespace: biological_process alt_id: GO:0000021 alt_id: GO:0007145 def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] synonym: "female meiotic recombination" NARROW [] synonym: "gene conversion with reciprocal crossover" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0035825 ! reciprocal DNA recombination relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007132 name: meiotic metaphase I namespace: biological_process def: "Metaphase occurring as part of meiosis I. Metaphase is the part of nuclear division in which, canonically, chromosomes become aligned on the equatorial plate of the cell. Meiosis I is the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other." [GOC:dph, GOC:mah] is_a: GO:0051323 ! metaphase relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007133 name: meiotic anaphase I namespace: biological_process def: "Anaphase occurring as part of meiosis I. Anaphase is the part of nuclear division in which chromosomes separate and migrate towards the poles of the spindle. Meiosis I is the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other." [GOC:dph, GOC:mah] is_a: GO:0051322 ! anaphase relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007134 name: meiotic telophase I namespace: biological_process def: "Telophase occurring as part of meiosis I. Telophase is the part of nuclear division that, canonically, begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. Meiosis I is the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other." [GOC:dph, GOC:mah] is_a: GO:0051326 ! telophase relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007135 name: meiosis II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Meiosis#Meiosis_II is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0007136 name: meiotic prophase II namespace: biological_process def: "Prophase occurring as part of meiosis II. Prophase is the part of nuclear division in which, canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. Meiosis II is the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [GOC:dph, GOC:mah] is_a: GO:0051324 ! prophase relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0007137 name: meiotic metaphase II namespace: biological_process def: "Metaphase occurring as part of meiosis II. Metaphase is the part of nuclear division in which, canonically, chromosomes become aligned on the equatorial plate of the cell. Meiosis II is the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [GOC:dph, GOC:mah] is_a: GO:0051323 ! metaphase relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0007138 name: meiotic anaphase II namespace: biological_process def: "Anaphase occurring as part of meiosis II. Anaphase is the part of nuclear division in which sister chromatids (or chromosomes) separate and migrate towards the poles of the spindle. Meiosis II is the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [GOC:dph, GOC:mah] is_a: GO:0051322 ! anaphase relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0007139 name: meiotic telophase II namespace: biological_process def: "Telophase occurring as part of meiosis II. Telophase is the part of nuclear division that, canonically, begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. Meiosis II is the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [GOC:dph, GOC:mah] is_a: GO:0051326 ! telophase relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0007140 name: male meiosis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] is_a: GO:0007126 ! meiosis [Term] id: GO:0007141 name: male meiosis I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah] is_a: GO:0007127 ! meiosis I relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007142 name: male meiosis II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah] is_a: GO:0007135 ! meiosis II relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007143 name: female meiosis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiosis ; GO:0007126'. is_a: GO:0007126 ! meiosis [Term] id: GO:0007144 name: female meiosis I namespace: biological_process def: "The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah] is_a: GO:0007127 ! meiosis I relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0007146 name: meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324] is_a: GO:0000707 ! meiotic DNA recombinase assembly [Term] id: GO:0007147 name: female meiosis II namespace: biological_process def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah] is_a: GO:0007135 ! meiosis II relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0007149 name: colony morphology namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it describes a phenotype rather than a biological goal. is_obsolete: true [Term] id: GO:0007150 name: growth pattern namespace: biological_process def: "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances." [GOC:jid] comment: This term was made obsolete because the original meaning of the term is unclear, the current definition is incorrect, and it does not describe a biological process. is_obsolete: true consider: GO:0040007 [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Cell_signaling is_a: GO:0009987 ! cellular process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "cell adhesion molecule activity" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0009987 ! cellular process is_a: GO:0022610 ! biological adhesion [Term] id: GO:0007156 name: homophilic cell adhesion namespace: biological_process def: "The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0007157 name: heterophilic cell-cell adhesion namespace: biological_process def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "agglutination" RELATED [GOC:mah] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0007158 name: neuron cell-cell adhesion namespace: biological_process def: "The attachment of a neuron to another cell via adhesion molecules." [GOC:go_curators] synonym: "neuron adhesion" EXACT [GOC:curators] synonym: "neuronal cell adhesion" EXACT [] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0007159 name: leukocyte cell-cell adhesion namespace: biological_process def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators] synonym: "leukocyte adhesion" EXACT [GOC:curators] synonym: "leukocyte cell adhesion" EXACT [] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0007160 name: cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] subset: gosubset_prok is_a: GO:0031589 ! cell-substrate adhesion [Term] id: GO:0007161 name: calcium-independent cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-independent cell adhesion molecule activity" RELATED [] is_a: GO:0007160 ! cell-matrix adhesion [Term] id: GO:0007162 name: negative regulation of cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "cell adhesion receptor inhibitor activity" RELATED [] synonym: "down regulation of cell adhesion" EXACT [] synonym: "down-regulation of cell adhesion" EXACT [] synonym: "downregulation of cell adhesion" EXACT [] synonym: "inhibition of cell adhesion" NARROW [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process alt_id: GO:0030012 alt_id: GO:0030467 def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_pombe synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0007164 name: establishment of tissue polarity namespace: biological_process def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023033 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [GOC:mah] xref: Reactome:1253589 "EGFR interacts with phospholipase C-gamma" xref: Reactome:1327107 "EGFR interacts with phospholipase C-gamma" xref: Reactome:1353201 "EGFR interacts with phospholipase C-gamma" xref: Reactome:1373377 "EGFR interacts with phospholipase C-gamma" xref: Reactome:1393403 "EGFR interacts with phospholipase C-gamma" xref: Reactome:1417898 "EGFR interacts with phospholipase C-gamma" xref: Reactome:1450988 "EGFR interacts with phospholipase C-gamma" xref: Reactome:212718 "EGFR interacts with phospholipase C-gamma" xref: Wikipedia:Signal_transduction is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051716 ! cellular response to stimulus relationship: part_of GO:0023052 ! signaling [Term] id: GO:0007166 name: cell surface receptor linked signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell." [GOC:mah] subset: gosubset_prok synonym: "cell surface receptor linked signal transduction" EXACT [] synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah] xref: Reactome:110437 "DILP binds to Drosophila insulin receptor (DINR)" is_a: GO:0007165 ! signal transduction [Term] id: GO:0007167 name: enzyme linked receptor protein signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase." [GOC:mah, ISBN:0185316194] synonym: "enzyme linked receptor protein signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007168 name: receptor guanylyl cyclase signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses guanylyl cyclase activity." [GOC:mah] synonym: "receptor guanylyl cyclase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007169 name: transmembrane receptor protein tyrosine kinase signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:ceb] synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT [] xref: Reactome:1253354 "Activation of TRKA receptors" xref: Reactome:1280292 "Activation of TRKA receptors" xref: Reactome:1299143 "Activation of TRKA receptors" xref: Reactome:1326870 "Activation of TRKA receptors" xref: Reactome:1352962 "Activation of TRKA receptors" xref: Reactome:1373164 "Activation of TRKA receptors" xref: Reactome:1393243 "Activation of TRKA receptors" xref: Reactome:1417668 "Activation of TRKA receptors" xref: Reactome:1450768 "Activation of TRKA receptors" xref: Reactome:187015 "Activation of TRKA receptors" is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007170 name: transmembrane receptor protein tyrosine kinase ligand binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0030971 [Term] id: GO:0007171 name: activation of transmembrane receptor protein tyrosine kinase activity namespace: biological_process def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb] synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb] synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0007172 name: signal complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors." [PMID:9646862] synonym: "signal complex formation" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0007173 name: epidermal growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "EGF receptor signaling pathway" EXACT [] synonym: "EGF receptor signalling pathway" EXACT [] synonym: "EGFR signaling pathway" EXACT [] synonym: "epidermal growth factor receptor signalling pathway" EXACT [] xref: Reactome:1253122 "Signaling by EGFR" xref: Reactome:1280057 "Signaling by EGFR" xref: Reactome:1298943 "Signaling by EGFR" xref: Reactome:1326627 "Signaling by EGFR" xref: Reactome:1352740 "Signaling by EGFR" xref: Reactome:1372951 "Signaling by EGFR" xref: Reactome:1392967 "Signaling by EGFR" xref: Reactome:1417447 "Signaling by EGFR" xref: Reactome:1450540 "Signaling by EGFR" xref: Reactome:1471057 "Signaling by EGFR" xref: Reactome:1483073 "Signaling by EGFR" xref: Reactome:1526796 "Signaling by EGFR" xref: Reactome:1532522 "Signaling by EGFR" xref: Reactome:177929 "Signaling by EGFR" is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0007174 name: epidermal growth factor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor." [GOC:bf, GOC:signaling, PMID:2985587] comment: This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'. synonym: "EGF breakdown" EXACT [GOC:bf] synonym: "EGF catabolism" EXACT [GOC:bf] synonym: "EGF receptor ligand processing" RELATED [GOC:bf] synonym: "epidermal growth factor breakdown" EXACT [GOC:bf] synonym: "epidermal growth factor catabolism" EXACT [GOC:bf] synonym: "epidermal growth factor ligand processing" RELATED [GOC:bf] synonym: "intracellular EGF processing" RELATED [PMID:2985587] synonym: "receptor-mediated EGF processing" RELATED [PMID:1683723] is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0007175 name: negative regulation of epidermal growth factor receptor activity namespace: biological_process alt_id: GO:0007177 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of EGF receptor activity." [GOC:go_curators] synonym: "down regulation of epidermal growth factor receptor activity" EXACT [] synonym: "down-regulation of epidermal growth factor receptor activity" EXACT [] synonym: "downregulation of epidermal growth factor receptor activity" EXACT [] synonym: "EGF receptor downregulation" EXACT [] synonym: "inhibition of epidermal growth factor receptor activity" NARROW [] synonym: "negative regulation of EGF receptor activity" EXACT [] synonym: "negative regulation of EGFR activity" EXACT [] is_a: GO:0007176 ! regulation of epidermal growth factor receptor activity is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity is_a: GO:2000272 ! negative regulation of receptor activity [Term] id: GO:0007176 name: regulation of epidermal growth factor receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of EGF receptor activity." [GOC:dph, GOC:go_curators] synonym: "regulation of EGF receptor activity" EXACT [] synonym: "regulation of EGFR activity" EXACT [] is_a: GO:0010469 ! regulation of receptor activity is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061097 ! regulation of protein tyrosine kinase activity [Term] id: GO:0007178 name: transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:mah] synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007179 name: transforming growth factor beta receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands." [GOC:mah] synonym: "TGF-beta receptor signaling pathway" EXACT [] synonym: "TGF-beta receptor signalling pathway" EXACT [] synonym: "TGFbeta receptor signaling pathway" EXACT [] synonym: "TGFbeta receptor signalling pathway" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway" EXACT [] xref: Reactome:1253382 "Signaling by TGF beta" xref: Reactome:1280322 "Signaling by TGF beta" xref: Reactome:1299171 "Signaling by TGF beta" xref: Reactome:1326900 "Signaling by TGF beta" xref: Reactome:1352992 "Signaling by TGF beta" xref: Reactome:1373190 "Signaling by TGF beta" xref: Reactome:1393201 "Signaling by TGF beta" xref: Reactome:1417696 "Signaling by TGF beta" xref: Reactome:1450798 "Signaling by TGF beta" xref: Reactome:1471212 "Signaling by TGF beta" xref: Reactome:170834 "Signaling by TGF beta" is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007180 name: transforming growth factor beta ligand binding to type II receptor namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function. synonym: "TGF-beta ligand binding to type II receptor" EXACT [] synonym: "TGFbeta ligand binding to type II receptor" EXACT [] is_obsolete: true consider: GO:0005026 consider: GO:0005160 consider: GO:0050431 [Term] id: GO:0007181 name: transforming growth factor beta receptor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Reactome:REACT_7425, Wikipedia:TGF_beta_signaling_pathway] synonym: "TGF-beta receptor complex assembly" EXACT [] synonym: "TGF-beta:type II receptor:type I receptor complex assembly" EXACT [] synonym: "TGFbeta receptor complex assembly" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0007182 name: common-partner SMAD protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus." [GOC:dph, ISBN:3527303782] synonym: "common mediator SMAD protein phosphorylation" EXACT [] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007183 name: SMAD protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:isa_complete] synonym: "SMAD protein heteromerization" NARROW [GOC:mah, PMID:9670020] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007184 name: SMAD protein import into nucleus namespace: biological_process def: "The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph] comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "SMAD protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0006606 ! protein import into nucleus relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007185 name: transmembrane receptor protein tyrosine phosphatase signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand." [GOC:mah] synonym: "transmembrane receptor protein tyrosine phosphatase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007186 name: G-protein coupled receptor protein signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:mah] synonym: "G protein coupled receptor protein signaling pathway" EXACT [] synonym: "G protein coupled receptor protein signalling pathway" EXACT [] synonym: "G-protein coupled receptor protein signal transduction" EXACT [] synonym: "G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "GPCR protein signaling pathway" EXACT [] synonym: "GPCR protein signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007187 name: G-protein signaling, coupled to cyclic nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide." [GOC:mah, ISBN:0815316194] synonym: "G protein signaling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling [Term] id: GO:0007188 name: G-protein signaling, coupled to cAMP nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP." [GOC:mah, ISBN:0815316194] synonym: "G protein signaling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G-protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] is_a: GO:0007187 ! G-protein signaling, coupled to cyclic nucleotide second messenger is_a: GO:0019933 ! cAMP-mediated signaling [Term] id: GO:0007189 name: activation of adenylate cyclase activity by G-protein signaling pathway namespace: biological_process alt_id: GO:0010580 def: "Any process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815316194] synonym: "activation of adenylate cyclase activity involved in G-protein signaling" EXACT [] synonym: "G protein signaling, adenylate cyclase activating pathway" EXACT [] synonym: "G protein signaling, adenylyl cyclase activating pathway" EXACT [] synonym: "G protein signalling, adenylate cyclase activating pathway" EXACT [] synonym: "G protein signalling, adenylyl cyclase activating pathway" EXACT [] synonym: "G-protein signaling, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signaling, adenylyl cyclase activating pathway" EXACT [] synonym: "G-protein signalling, adenylate cyclase activating pathway" EXACT [] synonym: "G-protein signalling, adenylyl cyclase activating pathway" EXACT [] xref: Reactome:1253380 "Adenylate cyclase activating pathway" xref: Reactome:1280320 "Adenylate cyclase activating pathway" xref: Reactome:1326898 "Adenylate cyclase activating pathway" xref: Reactome:1352990 "Adenylate cyclase activating pathway" xref: Reactome:1373189 "Adenylate cyclase activating pathway" xref: Reactome:1393199 "Adenylate cyclase activating pathway" xref: Reactome:1417694 "Adenylate cyclase activating pathway" xref: Reactome:1450796 "Adenylate cyclase activating pathway" xref: Reactome:1471210 "Adenylate cyclase activating pathway" xref: Reactome:1483210 "Adenylate cyclase activating pathway" xref: Reactome:1521164 "Adenylate cyclase activating pathway" xref: Reactome:170660 "Adenylate cyclase activating pathway" is_a: GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger is_a: GO:0007190 ! activation of adenylate cyclase activity is_a: GO:0010579 ! positive regulation of adenylate cyclase activity by G-protein signaling pathway [Term] id: GO:0007190 name: activation of adenylate cyclase activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GOC:ai] synonym: "adenylate cyclase activation" EXACT [GOC:dph, GOC:tb] synonym: "adenylate cyclase activator" RELATED [] synonym: "adenylyl cyclase activation" EXACT [] xref: Reactome:1234941 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1253419 "NGF-independant TRKA activation" xref: Reactome:1262329 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1280359 "NGF-independant TRKA activation" xref: Reactome:1299198 "NGF-independant TRKA activation" xref: Reactome:1308571 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1326937 "NGF-independant TRKA activation" xref: Reactome:1335470 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1353032 "NGF-independant TRKA activation" xref: Reactome:1359884 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1373225 "NGF-independant TRKA activation" xref: Reactome:1380559 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1393242 "NGF-independant TRKA activation" xref: Reactome:1401584 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1417734 "NGF-independant TRKA activation" xref: Reactome:1429468 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1450833 "NGF-independant TRKA activation" xref: Reactome:1458432 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1476336 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:1517968 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:170672 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:187024 "NGF-independant TRKA activation" is_a: GO:0045762 ! positive regulation of adenylate cyclase activity [Term] id: GO:0007191 name: activation of adenylate cyclase activity by dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:mah] synonym: "activation of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah] synonym: "dopamine receptor, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "dopamine receptor, adenylyl cyclase activating pathway" EXACT [] is_a: GO:0007189 ! activation of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0007192 name: activation of adenylate cyclase activity by serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of adenylate cyclase activity by serotonin receptor signalling pathway" EXACT [GOC:mah] synonym: "serotonin receptor, adenylate cyclase activating pathway" RELATED [GOC:dph, GOC:tb] synonym: "serotonin receptor, adenylyl cyclase activating pathway" EXACT [] is_a: GO:0007189 ! activation of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007210 ! serotonin receptor signaling pathway [Term] id: GO:0007193 name: inhibition of adenylate cyclase activity by G-protein signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815316194] synonym: "G protein signaling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G protein signalling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G-protein signaling, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G-protein signalling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G-protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] xref: Reactome:1253375 "Adenylate cyclase inhibitory pathway" xref: Reactome:1280315 "Adenylate cyclase inhibitory pathway" xref: Reactome:1299465 "Adenylate cyclase inhibitory pathway" xref: Reactome:1326893 "Adenylate cyclase inhibitory pathway" xref: Reactome:1352985 "Adenylate cyclase inhibitory pathway" xref: Reactome:1373183 "Adenylate cyclase inhibitory pathway" xref: Reactome:1393194 "Adenylate cyclase inhibitory pathway" xref: Reactome:1417688 "Adenylate cyclase inhibitory pathway" xref: Reactome:1450791 "Adenylate cyclase inhibitory pathway" xref: Reactome:1483204 "Adenylate cyclase inhibitory pathway" xref: Reactome:1521156 "Adenylate cyclase inhibitory pathway" xref: Reactome:170670 "Adenylate cyclase inhibitory pathway" is_a: GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger is_a: GO:0007194 ! negative regulation of adenylate cyclase activity [Term] id: GO:0007194 name: negative regulation of adenylate cyclase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] synonym: "adenylate cyclase inhibitor" RELATED [] synonym: "down regulation of adenylate cyclase activity" EXACT [] synonym: "down-regulation of adenylate cyclase activity" EXACT [] synonym: "downregulation of adenylate cyclase activity" EXACT [] synonym: "inhibition of adenylate cyclase activity" NARROW [] synonym: "negative regulation of adenylyl cyclase activity" EXACT [] is_a: GO:0031280 ! negative regulation of cyclase activity is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0051350 ! negative regulation of lyase activity [Term] id: GO:0007195 name: inhibition of adenylate cyclase activity by dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0007196 name: inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah] synonym: "metabotropic glutamate receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007216 ! metabotropic glutamate receptor signaling pathway [Term] id: GO:0007197 name: inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah] synonym: "muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007213 ! muscarinic acetylcholine receptor signaling pathway [Term] id: GO:0007198 name: inhibition of adenylate cyclase activity by serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "inhibition of adenylate cyclase activity by serotonin receptor signalling pathway" EXACT [GOC:mah] synonym: "serotonin receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "serotonin receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007210 ! serotonin receptor signaling pathway [Term] id: GO:0007199 name: G-protein signaling, coupled to cGMP nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase and a subsequent increase in the concentration of cyclic GMP." [GOC:mah, ISBN:0815316194] synonym: "G protein signaling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] is_a: GO:0007187 ! G-protein signaling, coupled to cyclic nucleotide second messenger is_a: GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0007200 name: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815316194] synonym: "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "phospholipase C-activating dopamine receptor signaling pathway" RELATED [GOC:dph, GOC:tb] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0007202 ! activation of phospholipase C activity is_a: GO:0048016 ! inositol phosphate-mediated signaling [Term] id: GO:0007201 name: G-protein dissociation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about. is_obsolete: true [Term] id: GO:0007202 name: activation of phospholipase C activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098] comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'. synonym: "phospholipase C activation" EXACT [GOC:dph, GOC:tb] xref: Reactome:1253022 "PLC-gamma1 signalling" xref: Reactome:1279951 "PLC-gamma1 signalling" xref: Reactome:1298844 "PLC-gamma1 signalling" xref: Reactome:1326527 "PLC-gamma1 signalling" xref: Reactome:1352636 "PLC-gamma1 signalling" xref: Reactome:1373022 "PLC-gamma1 signalling" xref: Reactome:1392874 "PLC-gamma1 signalling" xref: Reactome:1417515 "PLC-gamma1 signalling" xref: Reactome:1450444 "PLC-gamma1 signalling" xref: Reactome:1470969 "PLC-gamma1 signalling" xref: Reactome:1483005 "PLC-gamma1 signalling" xref: Reactome:1520993 "PLC-gamma1 signalling" xref: Reactome:1526854 "PLC-gamma1 signalling" xref: Reactome:1532581 "PLC-gamma1 signalling" xref: Reactome:1539301 "PLC-gamma1 signalling" xref: Reactome:167021 "PLC-gamma1 signalling" is_a: GO:0010863 ! positive regulation of phospholipase C activity [Term] id: GO:0007203 name: phosphatidylinositol-4,5-bisphosphate hydrolysis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because hydrolysis is a reaction, not a process. is_obsolete: true consider: GO:0004435 [Term] id: GO:0007204 name: elevation of cytosolic calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] synonym: "cytoplasmic calcium ion concentration elevation" BROAD [] synonym: "cytosolic calcium ion concentration elevation" EXACT [] synonym: "elevation of calcium ion concentration in cytoplasm" BROAD [] synonym: "elevation of calcium ion concentration in cytosol" EXACT [] synonym: "elevation of cytoplasmic calcium ion concentration" BROAD [] is_a: GO:0051480 ! cytosolic calcium ion homeostasis [Term] id: GO:0007205 name: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway namespace: biological_process def: "The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:mah] synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway" EXACT [GOC:mah] synonym: "PKC activation" EXACT [] synonym: "protein kinase C activation" EXACT [GOC:dph, GOC:tb] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0007206 name: activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah] synonym: "metabotropic glutamate receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0007216 ! metabotropic glutamate receptor signaling pathway [Term] id: GO:0007207 name: activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah] synonym: "muscarinic acetylcholine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0007213 ! muscarinic acetylcholine receptor signaling pathway [Term] id: GO:0007208 name: activation of phospholipase C activity by serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of phospholipase C activity by serotonin receptor signalling pathway" EXACT [GOC:mah] synonym: "serotonin receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0007210 ! serotonin receptor signaling pathway [Term] id: GO:0007209 name: activation of phospholipase C activity by tachykinin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of phospholipase C activity by tachykinin receptor signalling pathway" EXACT [GOC:mah] synonym: "tachykinin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0007217 ! tachykinin receptor signaling pathway [Term] id: GO:0007210 name: serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "serotonin receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007211 name: octopamine or tyramine signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of octopamine or tyramine binding to a cell surface receptor. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters." [GOC:mah, PMID:15355245] synonym: "octopamine or tyramine signalling pathway" EXACT [GOC:mah] synonym: "octopamine/tyramine signaling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007212 name: dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah] synonym: "dopamine receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007213 name: muscarinic acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to one of its physiological ligands; muscarinic acetylcholine receptors activate inhibitory G proteins and can be activated by the fungal alkaloid muscarine." [GOC:mah, ISBN:0815316194] synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007214 name: gamma-aminobutyric acid signaling pathway namespace: biological_process def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor." [GOC:mah] synonym: "4-aminobutanoate signaling pathway" EXACT [] synonym: "4-aminobutanoate signalling pathway" EXACT [] synonym: "4-aminobutyrate signaling pathway" EXACT [] synonym: "4-aminobutyrate signalling pathway" EXACT [] synonym: "GABA signaling pathway" EXACT [] synonym: "GABA signalling pathway" EXACT [] synonym: "gamma-aminobutyric acid signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007215 name: glutamate signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor." [GOC:mah, PMID:9131252] synonym: "glutamate signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007216 name: metabotropic glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins." [GOC:mah, PMID:9131252] synonym: "metabotropic glutamate receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0007215 ! glutamate signaling pathway [Term] id: GO:0007217 name: tachykinin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970] synonym: "tachykinin signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007218 name: neuropeptide signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] synonym: "neuropeptide signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007219 name: Notch signaling pathway namespace: biological_process alt_id: GO:0030179 def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell." [GOC:go_curators] synonym: "N signaling pathway" EXACT [] synonym: "N signalling pathway" EXACT [] synonym: "Notch receptor signaling pathway" EXACT [] synonym: "Notch receptor signalling pathway" EXACT [] synonym: "Notch signalling pathway" EXACT [] synonym: "Notch-receptor signaling pathway" EXACT [] synonym: "Notch-receptor signalling pathway" EXACT [] xref: Reactome:1253285 "Signaling by Notch" xref: Reactome:1280221 "Signaling by Notch" xref: Reactome:1299083 "Signaling by Notch" xref: Reactome:1326798 "Signaling by Notch" xref: Reactome:1352900 "Signaling by Notch" xref: Reactome:1373104 "Signaling by Notch" xref: Reactome:1393122 "Signaling by Notch" xref: Reactome:1417609 "Signaling by Notch" xref: Reactome:1450700 "Signaling by Notch" xref: Reactome:1471163 "Signaling by Notch" xref: Reactome:157118 "Signaling by Notch" xref: Wikipedia:Notch_signaling_pathway is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007220 name: Notch receptor processing namespace: biological_process def: "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] synonym: "N receptor processing" EXACT [] xref: Reactome:1253288 "A third proteolytic cleavage releases NICD" xref: Reactome:1253289 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:1280224 "A third proteolytic cleavage releases NICD" xref: Reactome:1280225 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:1299086 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:1299088 "A third proteolytic cleavage releases NICD" xref: Reactome:1326801 "A third proteolytic cleavage releases NICD" xref: Reactome:1326802 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:1352903 "A third proteolytic cleavage releases NICD" xref: Reactome:1352904 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:1373107 "A third proteolytic cleavage releases NICD" xref: Reactome:1373108 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:1393125 "A third proteolytic cleavage releases NICD" xref: Reactome:1393126 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:1417612 "A third proteolytic cleavage releases NICD" xref: Reactome:1417613 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:1450703 "A third proteolytic cleavage releases NICD" xref: Reactome:1450704 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:1471166 "A third proteolytic cleavage releases NICD" xref: Reactome:1471167 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:156988 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:157212 "A third proteolytic cleavage releases NICD" is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0007221 name: positive regulation of transcription of Notch receptor target namespace: biological_process def: "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094] synonym: "N receptor target transcription factor activation" RELATED [] synonym: "Notch receptor target transcription factor activation" RELATED [] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0007219 ! Notch signaling pathway [Term] id: GO:0007223 name: Wnt receptor signaling pathway, calcium modulating pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397] synonym: "frizzled-2 signaling pathway" NARROW [] synonym: "frizzled-2 signalling pathway" NARROW [] synonym: "non-canonical Wnt signaling pathway" RELATED [] is_a: GO:0035567 ! non-canonical Wnt receptor signaling pathway [Term] id: GO:0007224 name: smoothened signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] synonym: "hedgehog signaling pathway" EXACT [] synonym: "hh signaling pathway" NARROW [] synonym: "hh signalling pathway" NARROW [] synonym: "Shh signaling pathway" RELATED [GOC:dph] synonym: "smoothened signalling pathway" EXACT [] synonym: "Sonic hedgehog signaling pathway" NARROW [GOC:dph] xref: Wikipedia:Hedgehog_signaling_pathway is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007225 name: patched ligand maturation namespace: biological_process def: "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups." [PMID:15057936] synonym: "Hedgehog protein processing" NARROW [] synonym: "hh protein processing" EXACT [] synonym: "patched ligand processing" RELATED [] is_a: GO:0035638 ! signal maturation is_a: GO:0051604 ! protein maturation relationship: part_of GO:0045880 ! positive regulation of smoothened signaling pathway [Term] id: GO:0007227 name: signal transduction downstream of smoothened namespace: biological_process def: "The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway." [PMID:15057936] is_a: GO:0035557 ! intracellular signal transduction involved in cell surface receptor linked signaling relationship: part_of GO:0007224 ! smoothened signaling pathway [Term] id: GO:0007228 name: positive regulation of hh target transcription factor activity namespace: biological_process def: "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936] synonym: "activation of hh target transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of hedgehog target transcription factor" EXACT [GOC:bf, GOC:ecd] is_a: GO:0051091 ! positive regulation of sequence-specific DNA binding transcription factor activity relationship: part_of GO:0007227 ! signal transduction downstream of smoothened [Term] id: GO:0007229 name: integrin-mediated signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands." [GOC:mah] synonym: "integrin-mediated signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007230 name: calcium-o-sensing receptor pathway namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it does not make sense. is_obsolete: true consider: GO:0019722 [Term] id: GO:0007231 name: osmosensory signaling pathway namespace: biological_process def: "The series of molecular signals initiated in response to osmotic change." [GOC:jl] subset: gosubset_prok synonym: "osmolarity sensing" EXACT [] synonym: "osmolarity sensing signaling pathway" EXACT [] synonym: "osmolarity sensing signalling pathway" EXACT [] synonym: "osmosensory signalling pathway" EXACT [] synonym: "signal transduction during osmotic stress" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071470 ! cellular response to osmotic stress [Term] id: GO:0007232 name: osmosensory signaling pathway via Sho1 osmosensor namespace: biological_process def: "A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system." [GOC:jl] synonym: "osmosensory signalling pathway via Sho1 osmosensor" EXACT [] synonym: "signal transduction during osmotic stress via Sho1 osmosensor" EXACT [] is_a: GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0007234 name: osmosensory signaling pathway via two-component system namespace: biological_process def: "A series of molecular signals generated in response to osmotic change, as mediated through a two-component (phosphorelay) system." [PMID:9843501] subset: gosubset_prok synonym: "osmolarity sensing via two-component system" EXACT [] synonym: "osmolarity signaling pathway via two-component system" EXACT [] synonym: "osmolarity signalling pathway via two-component system" EXACT [] synonym: "osmosensory signalling pathway via two-component system" EXACT [] synonym: "signal transduction during osmotic stress via two-component system" EXACT [] is_a: GO:0000160 ! two-component signal transduction system (phosphorelay) is_a: GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0007235 name: activation of Ypd1 protein namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007236 name: activation of Ssk1 protein namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007237 name: activation of Ssk2/Ssk22 proteins namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007238 name: activation of Pbs2 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007239 name: activation of Hog1 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007240 name: nuclear translocation of Hog1 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007241 name: inactivation of Hog1 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007243 name: intracellular protein kinase cascade namespace: biological_process def: "A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:bf, GOC:jl] synonym: "protein kinase cascade" EXACT [] xref: Reactome:1253340 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1280278 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1299132 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1326856 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1352950 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1373152 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1393168 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1417658 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1450757 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1471197 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1483190 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1521144 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1526898 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:1532627 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:163358 "PKA-mediated phosphorylation of key metabolic factors" is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0007244 name: MAPKKK cascade (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007245 name: activation of MAPKKK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007246 name: activation of MAPKK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007247 name: activation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true consider: GO:0000750 [Term] id: GO:0007248 name: nuclear translocation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007249 name: I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase." [GOC:jl, PMID:12773372] synonym: "activation of the inhibitor of kappa kinase" RELATED [] synonym: "NF-kappaB cascade" EXACT [] synonym: "NIK-I-kappaB/NF-kappaB cascade" EXACT [] xref: Reactome:937072 "TRAF6 mediated induction of TAK1 complex" is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0007250 name: activation of NF-kappaB-inducing kinase activity namespace: biological_process def: "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues." [GOC:jl, PMID:12773372] synonym: "positive regulation of NF-kappaB-inducing kinase activity" EXACT [] xref: Reactome:434001 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0007251 name: activation of the inhibitor of kappa kinase namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its meaning was unclear. is_obsolete: true consider: GO:0007249 [Term] id: GO:0007252 name: I-kappaB phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into an I-kappaB protein." [GOC:jl] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0007253 name: cytoplasmic sequestering of NF-kappaB namespace: biological_process def: "The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] synonym: "cytoplasmic NF-kappaB retention" EXACT [] synonym: "cytoplasmic NF-kappaB sequestration" EXACT [] synonym: "cytoplasmic NF-kappaB storage" EXACT [] synonym: "cytoplasmic retention of NF-kappaB" EXACT [] synonym: "cytoplasmic sequestration of NF-kappaB" EXACT [] synonym: "cytoplasmic storage of NF-kappaB" EXACT [] synonym: "maintenance of NF-kappaB location in cytoplasm" EXACT [GOC:dph, GOC:tb] is_a: GO:0042347 ! negative regulation of NF-kappaB import into nucleus is_a: GO:0042994 ! cytoplasmic sequestering of transcription factor relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0007254 name: JNK cascade namespace: biological_process def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] synonym: "JNK1 cascade" NARROW [GOC:add] synonym: "JNK2 cascade" NARROW [GOC:add] synonym: "JNK3 cascade" NARROW [GOC:add] synonym: "MAPK10 cascade" NARROW [GOC:add] synonym: "MAPK8 cascade" NARROW [GOC:add] synonym: "MAPK9 cascade" NARROW [GOC:add] synonym: "SAPK cascade" BROAD [] synonym: "stress-activated protein kinase cascade" BROAD [] xref: Reactome:1253365 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1280305 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1299157 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1326883 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1352975 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1373172 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1393183 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1417675 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1450781 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1483199 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1526902 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:1532635 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:450321 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" is_a: GO:0000165 ! MAPKKK cascade is_a: GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0007256 name: activation of JNKK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] synonym: "activation of JUN kinase kinase activity" EXACT [] synonym: "positive regulation of JUNKK activity" BROAD [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007257 name: activation of JUN kinase activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK)." [GOC:bf] synonym: "activation of SAPK activity" BROAD [] xref: Reactome:437986 "Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation" is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0043507 ! positive regulation of JUN kinase activity relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007258 name: JUN phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a JUN protein." [GOC:jl] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007259 name: JAK-STAT cascade namespace: biological_process def: "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028] is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0007260 name: tyrosine phosphorylation of STAT protein namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: part_of GO:0007259 ! JAK-STAT cascade [Term] id: GO:0007261 name: JAK-induced STAT protein dimerization namespace: biological_process def: "The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007259 ! JAK-STAT cascade [Term] id: GO:0007262 name: STAT protein import into nucleus namespace: biological_process def: "The directed movement of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "STAT protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0006606 ! protein import into nucleus relationship: part_of GO:0007259 ! JAK-STAT cascade [Term] id: GO:0007263 name: nitric oxide mediated signal transduction namespace: biological_process def: "A series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:jl] synonym: "nitric oxide-mediated signal transduction" EXACT [] synonym: "NO mediated signal transduction" EXACT [] synonym: "NO-mediated signal transduction" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0007264 name: small GTPase mediated signal transduction namespace: biological_process def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] subset: gosubset_prok synonym: "small GTPase-mediated signal transduction" EXACT [] xref: Reactome:1253126 "Signalling to p38 via RIT and RIN" xref: Reactome:1253496 "Signaling by Rho GTPases" xref: Reactome:1280061 "Signalling to p38 via RIT and RIN" xref: Reactome:1280435 "Signaling by Rho GTPases" xref: Reactome:1298953 "Signalling to p38 via RIT and RIN" xref: Reactome:1299267 "Signaling by Rho GTPases" xref: Reactome:1326631 "Signalling to p38 via RIT and RIN" xref: Reactome:1327013 "Signaling by Rho GTPases" xref: Reactome:1352744 "Signalling to p38 via RIT and RIN" xref: Reactome:1353107 "Signaling by Rho GTPases" xref: Reactome:1372955 "Signalling to p38 via RIT and RIN" xref: Reactome:1373296 "Signaling by Rho GTPases" xref: Reactome:1392971 "Signalling to p38 via RIT and RIN" xref: Reactome:1393309 "Signaling by Rho GTPases" xref: Reactome:1417451 "Signalling to p38 via RIT and RIN" xref: Reactome:1417807 "Signaling by Rho GTPases" xref: Reactome:1450544 "Signalling to p38 via RIT and RIN" xref: Reactome:1450905 "Signaling by Rho GTPases" xref: Reactome:1471061 "Signalling to p38 via RIT and RIN" xref: Reactome:1471286 "Signaling by Rho GTPases" xref: Reactome:1483077 "Signalling to p38 via RIT and RIN" xref: Reactome:1483259 "Signaling by Rho GTPases" xref: Reactome:1496936 "Signaling by Rho GTPases" xref: Reactome:1514323 "Signaling by Rho GTPases" xref: Reactome:1521191 "Signaling by Rho GTPases" xref: Reactome:1526800 "Signalling to p38 via RIT and RIN" xref: Reactome:1526936 "Signaling by Rho GTPases" xref: Reactome:1532526 "Signalling to p38 via RIT and RIN" xref: Reactome:1532675 "Signaling by Rho GTPases" xref: Reactome:187706 "Signalling to p38 via RIT and RIN" xref: Reactome:194315 "Signaling by Rho GTPases" is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0007265 name: Ras protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Ras mediated signal transduction" EXACT [] xref: Reactome:1253036 "Signalling to RAS" xref: Reactome:1279968 "Signalling to RAS" xref: Reactome:1298857 "Signalling to RAS" xref: Reactome:1326541 "Signalling to RAS" xref: Reactome:1352653 "Signalling to RAS" xref: Reactome:1372869 "Signalling to RAS" xref: Reactome:1392891 "Signalling to RAS" xref: Reactome:1417358 "Signalling to RAS" xref: Reactome:1450461 "Signalling to RAS" xref: Reactome:1471051 "Signalling to RAS" xref: Reactome:1483067 "Signalling to RAS" xref: Reactome:1526788 "Signalling to RAS" xref: Reactome:1532514 "Signalling to RAS" xref: Reactome:167044 "Signalling to RAS" is_a: GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0007266 name: Rho protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Rho mediated signal transduction" EXACT [] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another." [GOC:mah] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "cell-cell signalling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0007268 name: synaptic transmission namespace: biological_process def: "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] synonym: "neurotransmission" RELATED [GOC:dph] synonym: "regulation of synapse" RELATED [] synonym: "signal transmission across a synapse" EXACT [] xref: Reactome:112315 "Transmission across Chemical Synapses" xref: Reactome:112316 "Synaptic Transmission" xref: Reactome:1252936 "Transmission across Chemical Synapses" xref: Reactome:1252937 "Synaptic Transmission" xref: Reactome:1279870 "Transmission across Chemical Synapses" xref: Reactome:1279871 "Synaptic Transmission" xref: Reactome:1298784 "Transmission across Chemical Synapses" xref: Reactome:1298785 "Synaptic Transmission" xref: Reactome:1326439 "Transmission across Chemical Synapses" xref: Reactome:1326440 "Synaptic Transmission" xref: Reactome:1352555 "Transmission across Chemical Synapses" xref: Reactome:1352556 "Synaptic Transmission" xref: Reactome:1372782 "Transmission across Chemical Synapses" xref: Reactome:1372783 "Synaptic Transmission" xref: Reactome:1392792 "Transmission across Chemical Synapses" xref: Reactome:1392793 "Synaptic Transmission" xref: Reactome:1417269 "Transmission across Chemical Synapses" xref: Reactome:1417270 "Synaptic Transmission" xref: Reactome:1450358 "Transmission across Chemical Synapses" xref: Reactome:1450359 "Synaptic Transmission" xref: Reactome:1470897 "Transmission across Chemical Synapses" xref: Reactome:1470898 "Synaptic Transmission" xref: Reactome:1482928 "Transmission across Chemical Synapses" xref: Reactome:1482929 "Synaptic Transmission" xref: Reactome:1496998 "Transmission across Chemical Synapses" xref: Reactome:1496999 "Synaptic Transmission" xref: Reactome:1514385 "Transmission across Chemical Synapses" xref: Reactome:1514386 "Synaptic Transmission" xref: Reactome:1521162 "Transmission across Chemical Synapses" xref: Reactome:1521163 "Synaptic Transmission" xref: Reactome:1526686 "Transmission across Chemical Synapses" xref: Reactome:1526687 "Synaptic Transmission" xref: Reactome:1532415 "Transmission across Chemical Synapses" xref: Reactome:1532416 "Synaptic Transmission" xref: Reactome:1537980 "Transmission across Chemical Synapses" xref: Reactome:1537981 "Synaptic Transmission" xref: Reactome:1539313 "Transmission across Chemical Synapses" xref: Reactome:1539314 "Synaptic Transmission" xref: Wikipedia:Neurotransmission is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0019226 ! transmission of nerve impulse [Term] id: GO:0007269 name: neurotransmitter secretion namespace: biological_process def: "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] synonym: "neurotransmitter release" EXACT [] xref: Reactome:112310 "Neurotransmitter Release Cycle" xref: Reactome:1252939 "Neurotransmitter Release Cycle" xref: Reactome:1279873 "Neurotransmitter Release Cycle" xref: Reactome:1298787 "Neurotransmitter Release Cycle" xref: Reactome:1326442 "Neurotransmitter Release Cycle" xref: Reactome:1352558 "Neurotransmitter Release Cycle" xref: Reactome:1372785 "Neurotransmitter Release Cycle" xref: Reactome:1392795 "Neurotransmitter Release Cycle" xref: Reactome:1417272 "Neurotransmitter Release Cycle" xref: Reactome:1450361 "Neurotransmitter Release Cycle" xref: Reactome:1470900 "Neurotransmitter Release Cycle" xref: Reactome:1482931 "Neurotransmitter Release Cycle" xref: Reactome:1496997 "Neurotransmitter Release Cycle" xref: Reactome:1514384 "Neurotransmitter Release Cycle" xref: Reactome:1537979 "Neurotransmitter Release Cycle" xref: Reactome:1539352 "Neurotransmitter Release Cycle" xref: Reactome:168799 "Botulinum neurotoxicity" is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0023061 ! signal release is_a: GO:0032940 ! secretion by cell [Term] id: GO:0007270 name: neuron-neuron synaptic transmission namespace: biological_process def: "The process of communication from a neuron to another neuron across a synapse." [GOC:add, GOC:jl, MeSH:D009435] synonym: "nerve-nerve synaptic transmission" RELATED [] is_a: GO:0007268 ! synaptic transmission [Term] id: GO:0007271 name: synaptic transmission, cholinergic namespace: biological_process def: "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine." [GOC:kmv, GOC:pr, http://en.wikipedia.org/wiki/Cholinergic] is_a: GO:0007268 ! synaptic transmission [Term] id: GO:0007272 name: ensheathment of neurons namespace: biological_process def: "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb] synonym: "ionic insulation of neurons by glial cells" RELATED [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0019228 ! regulation of action potential in neuron [Term] id: GO:0007273 name: regulation of synapse namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string made no sense. is_obsolete: true consider: GO:0007268 [Term] id: GO:0007274 name: neuromuscular synaptic transmission namespace: biological_process def: "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] is_a: GO:0007268 ! synaptic transmission [Term] id: GO:0007275 name: multicellular organismal development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process is_a: GO:0032502 ! developmental process [Term] id: GO:0007276 name: gamete generation namespace: biological_process alt_id: GO:0009552 def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] synonym: "gametogenesis" RELATED [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007277 name: pole cell development namespace: biological_process def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007278 name: pole cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0001709 ! cell fate determination is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007277 ! pole cell development [Term] id: GO:0007279 name: pole cell formation namespace: biological_process def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007349 ! cellularization relationship: part_of GO:0007277 ! pole cell development [Term] id: GO:0007280 name: pole cell migration namespace: biological_process def: "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212] comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. is_a: GO:0008354 ! germ cell migration [Term] id: GO:0007281 name: germ cell development namespace: biological_process def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] synonym: "germ-cell development" EXACT [] synonym: "primordial germ cell development" NARROW [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007282 name: cystoblast division namespace: biological_process def: "The four rounds of incomplete mitosis undergone by the cystoblast to form a 16-cell cyst. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this is found in Drosophila melanogaster." [PMID:11131529] synonym: "cystoblast cell division" EXACT [] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007281 ! germ cell development [Term] id: GO:0007283 name: spermatogenesis namespace: biological_process def: "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] synonym: "generation of spermatozoa" EXACT systematic_synonym [] xref: Wikipedia:Spermatogenesis is_a: GO:0048232 ! male gamete generation [Term] id: GO:0007284 name: spermatogonial cell division namespace: biological_process def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form a cyst of secondary spermatogonia (primary spermatocytes)." [GOC:bf, ISBN:0879694238] comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'. is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051301 ! cell division relationship: part_of GO:0048136 ! male germ-line cyst formation [Term] id: GO:0007285 name: primary spermatocyte growth namespace: biological_process def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048588 ! developmental cell growth is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0007286 name: spermatid development namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] synonym: "spermatid cell development" EXACT [] synonym: "spermiogenesis" EXACT [] xref: Wikipedia:Spermiogenesis is_a: GO:0007281 ! germ cell development relationship: part_of GO:0048515 ! spermatid differentiation [Term] id: GO:0007287 name: Nebenkern assembly namespace: biological_process def: "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern." [GOC:bf, ISBN:0879694238] comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'. synonym: "Nebenkern formation" RELATED [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0008053 ! mitochondrial fusion is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007288 name: sperm axoneme assembly namespace: biological_process def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, ISBN:0198547684] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0035084 ! flagellar axoneme assembly is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007289 name: spermatid nucleus differentiation namespace: biological_process def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] comment: See also the Cell Ontology term 'spermatid ; CL:0000018'. synonym: "spermatid nuclear differentiation" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007290 name: spermatid nucleus elongation namespace: biological_process def: "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "spermatid nuclear elongation" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0007291 name: sperm individualization namespace: biological_process def: "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007349 ! cellularization relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007292 name: female gamete generation namespace: biological_process def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0007276 ! gamete generation [Term] id: GO:0007293 name: germarium-derived egg chamber formation namespace: biological_process def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007294 name: germarium-derived oocyte fate determination namespace: biological_process alt_id: GO:0016350 def: "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maintenance of oocyte identity" RELATED [] synonym: "oocyte cell fate determination" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030716 ! oocyte fate determination is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030706 ! germarium-derived oocyte differentiation [Term] id: GO:0007295 name: growth of a germarium-derived egg chamber namespace: biological_process def: "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "egg chamber growth" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007296 name: vitellogenesis namespace: biological_process def: "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238] synonym: "yolk production" EXACT systematic_synonym [] xref: Wikipedia:Vitellogenesis is_a: GO:0007028 ! cytoplasm organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0007297 name: ovarian follicle cell migration namespace: biological_process def: "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "follicle cell migration" BROAD [] is_a: GO:0016477 ! cell migration is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007298 name: border follicle cell migration namespace: biological_process def: "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "border cell migration" BROAD [] is_a: GO:0007297 ! ovarian follicle cell migration [Term] id: GO:0007299 name: ovarian follicle cell-cell adhesion namespace: biological_process def: "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496] synonym: "follicle cell adhesion" BROAD [] synonym: "ovarian follicle cell adhesion" EXACT [GOC:curators] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007300 name: ovarian nurse cell to oocyte transport namespace: biological_process def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "nurse cell to oocyte transport" BROAD [] is_a: GO:0006810 ! transport relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007301 name: female germline ring canal formation namespace: biological_process def: "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238] synonym: "nurse cell ring canal formation" NARROW [] synonym: "ovarian ring canal formation" NARROW [] is_a: GO:0030725 ! germline ring canal formation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007293 ! germarium-derived egg chamber formation relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007302 name: nurse cell nucleus anchoring namespace: biological_process def: "Attachment of the nurse cell nucleus to the plasma membrane." [ISBN:0879694238] is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007303 name: cytoplasmic transport, nurse cell to oocyte namespace: biological_process def: "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] is_a: GO:0016482 ! cytoplasmic transport relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007304 name: chorion-containing eggshell formation namespace: biological_process def: "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "eggshell formation" BROAD [] is_a: GO:0030703 ! eggshell formation relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007305 name: vitelline membrane formation involved in chorion-containing eggshell formation namespace: biological_process def: "Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "vitelline membrane formation in chorion-containing eggshell" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0030704 ! vitelline membrane formation relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0007306 name: eggshell chorion assembly namespace: biological_process def: "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "eggshell chorion formation" EXACT [GOC:dph, GOC:tb] synonym: "insect chorion formation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0007307 name: eggshell chorion gene amplification namespace: biological_process def: "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771] is_a: GO:0006277 ! DNA amplification is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007306 ! eggshell chorion assembly [Term] id: GO:0007308 name: oocyte construction namespace: biological_process alt_id: GO:0048110 def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0007309 name: oocyte axis specification namespace: biological_process alt_id: GO:0048111 def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte axis determination" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009798 ! axis specification relationship: part_of GO:0007308 ! oocyte construction [Term] id: GO:0007310 name: oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0008072 alt_id: GO:0048123 def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb] synonym: "oocyte dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0007309 ! oocyte axis specification is_a: GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0007311 name: maternal specification of dorsal/ventral axis, oocyte, germ-line encoded namespace: biological_process alt_id: GO:0048124 def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" EXACT [GOC:dph, GOC:tb] synonym: "maternal specification of dorsal-ventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] synonym: "maternal specification of dorsoventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] is_a: GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0007312 name: oocyte nucleus migration involved in oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0008102 alt_id: GO:0048128 def: "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] synonym: "oocyte axis determination, oocyte nuclear migration" EXACT [] synonym: "oocyte axis determination, oocyte nucleus migration" EXACT [] synonym: "oocyte nuclear migration during oocyte axis determination" EXACT [] synonym: "oocyte nucleus migration during oocyte axis determination" EXACT [GOC:dph, GOC:tb] synonym: "oocyte nucleus migration during oocyte axis specification" RELATED [GOC:dph, GOC:tb] is_a: GO:0007097 ! nuclear migration is_a: GO:0030722 ! establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [Term] id: GO:0007313 name: maternal specification of dorsal/ventral axis, oocyte, soma encoded namespace: biological_process alt_id: GO:0048125 def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded" EXACT [GOC:dph, GOC:tb] synonym: "maternal specification of dorsal-ventral axis, oocyte, soma encoded" EXACT [GOC:mah] synonym: "maternal specification of dorsoventral axis, oocyte, soma encoded" EXACT [GOC:mah] is_a: GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0007314 name: oocyte anterior/posterior axis specification namespace: biological_process alt_id: GO:0048112 def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb] is_a: GO:0007309 ! oocyte axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0008358 ! maternal determination of anterior/posterior axis, embryo [Term] id: GO:0007315 name: pole plasm assembly namespace: biological_process alt_id: GO:0048113 def: "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] is_a: GO:0007028 ! cytoplasm organization is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification [Term] id: GO:0007316 name: pole plasm RNA localization namespace: biological_process alt_id: GO:0048116 def: "Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of pole plasm RNA localization" EXACT [] synonym: "oocyte pole plasm RNA localization" EXACT [] synonym: "pole plasm RNA localisation" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0007317 name: regulation of pole plasm oskar mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] synonym: "regulation of oocyte pole plasm oskar mRNA localization" EXACT [] synonym: "regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060281 ! regulation of oocyte development is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0045451 ! pole plasm oskar mRNA localization [Term] id: GO:0007318 name: pole plasm protein localization namespace: biological_process alt_id: GO:0048115 def: "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of pole plasm protein localization" EXACT [] synonym: "oocyte pole plasm protein localization" EXACT [] synonym: "pole plasm protein localisation" EXACT [GOC:mah] is_a: GO:0008105 ! asymmetric protein localization relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0007319 name: negative regulation of oskar mRNA translation namespace: biological_process def: "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] synonym: "down regulation of oskar mRNA translation" EXACT [] synonym: "down-regulation of oskar mRNA translation" EXACT [] synonym: "downregulation of oskar mRNA translation" EXACT [] synonym: "inhibition of oskar mRNA translation" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0046011 ! regulation of oskar mRNA translation [Term] id: GO:0007320 name: insemination namespace: biological_process def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089] xref: Wikipedia:Insemination is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007620 ! copulation [Term] id: GO:0007321 name: sperm displacement namespace: biological_process def: "The physical displacement of sperm stored from previous mating encounters." [PMID:10440373] is_a: GO:0046692 ! sperm competition [Term] id: GO:0007323 name: peptide pheromone maturation namespace: biological_process alt_id: GO:0007324 alt_id: GO:0007326 alt_id: GO:0046613 def: "The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] subset: gosubset_prok synonym: "pheromone processing" EXACT [] is_a: GO:0051604 ! protein maturation [Term] id: GO:0007329 name: positive regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT [] synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] is_a: GO:0009371 ! positive regulation of transcription by pheromones is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones [Term] id: GO:0007336 name: bilateral process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it gives no indication of what it refers to. is_obsolete: true [Term] id: GO:0007337 name: unilateral process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it gives no indication of what it refers to. is_obsolete: true [Term] id: GO:0007338 name: single fertilization namespace: biological_process def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] synonym: "zygote biosynthesis" BROAD [] synonym: "zygote formation" BROAD [] is_a: GO:0009566 ! fertilization [Term] id: GO:0007339 name: binding of sperm to zona pellucida namespace: biological_process def: "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] synonym: "ZPG binding" RELATED [] is_a: GO:0035036 ! sperm-egg recognition [Term] id: GO:0007340 name: acrosome reaction namespace: biological_process def: "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg." [GOC:dph, PMID:3886029] xref: Wikipedia:Acrosome_reaction is_a: GO:0017156 ! calcium ion-dependent exocytosis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007341 name: penetration of zona pellucida namespace: biological_process def: "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007342 name: fusion of sperm to egg plasma membrane namespace: biological_process def: "The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] synonym: "sperm-oocyte fusion" NARROW [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045026 ! plasma membrane fusion relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007343 name: egg activation namespace: biological_process def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] xref: Wikipedia:Egg_activation is_a: GO:0001775 ! cell activation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007344 name: pronuclear fusion namespace: biological_process def: "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X] is_a: GO:0000741 ! karyogamy is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007345 name: embryogenesis and morphogenesis namespace: biological_process def: "OBSOLETE. Formation and development of an embryo and its organized structures." [GOC:ems, ISBN:0070524300, ISBN:0140512888] comment: This term was made obsolete because more appropriate terms were created. Morphogenesis in plants also occurs outside of embryogenesis. is_obsolete: true consider: GO:0009653 consider: GO:0009790 [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_pombe synonym: "control of mitotic cell cycle progression" EXACT [] synonym: "mitotic cell cycle control" EXACT [] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle relationship: regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0007347 name: regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "preblastoderm mitotic cell cycle control" EXACT [] synonym: "preblastoderm mitotic cell cycle modulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulator" RELATED [] synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic relationship: regulates GO:0035185 ! preblastoderm mitotic cell cycle [Term] id: GO:0007348 name: regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of syncytial blastoderm cell cycle progression" EXACT [] synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of syncytial blastoderm cell cycle" EXACT [] synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "syncytial blastoderm cell cycle control" EXACT [] synonym: "syncytial blastoderm cell cycle modulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulator" RELATED [] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic is_a: GO:0022402 ! cell cycle process relationship: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle [Term] id: GO:0007349 name: cellularization namespace: biological_process alt_id: GO:0009796 def: "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007350 name: blastoderm segmentation namespace: biological_process def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification is_a: GO:0035282 ! segmentation [Term] id: GO:0007351 name: tripartite regional subdivision namespace: biological_process def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0007352 name: zygotic specification of dorsal/ventral axis namespace: biological_process def: "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf] synonym: "zygotic determination of dorsal-ventral axis" RELATED [GOC:mah] synonym: "zygotic determination of dorsal/ventral axis" RELATED [GOC:dph] synonym: "zygotic determination of dorsoventral axis" RELATED [GOC:mah] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0007353 name: ventral/lateral system namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0009880 [Term] id: GO:0007354 name: zygotic determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0008595 ! anterior/posterior axis specification, embryo [Term] id: GO:0007355 name: anterior region determination namespace: biological_process def: "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007356 name: thorax and anterior abdomen determination namespace: biological_process def: "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007357 name: positive regulation of central gap gene transcription namespace: biological_process def: "The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "activation of central gap gene" BROAD [] synonym: "activation of central gap gene transcription" NARROW [] synonym: "stimulation of central gap gene transcription" NARROW [] synonym: "up regulation of central gap gene transcription" EXACT [] synonym: "up-regulation of central gap gene transcription" EXACT [] synonym: "upregulation of central gap gene transcription" EXACT [] is_a: GO:0044324 ! regulation of transcription involved in anterior/posterior axis specification is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0007356 ! thorax and anterior abdomen determination [Term] id: GO:0007358 name: establishment of central gap gene boundaries namespace: biological_process def: "Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007356 ! thorax and anterior abdomen determination [Term] id: GO:0007359 name: posterior abdomen determination namespace: biological_process def: "The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] comment: Note that this process is exemplified in insects by the actions of the knirps gene product. is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007360 name: positive regulation of posterior gap gene transcription namespace: biological_process def: "The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "activation of posterior gap gene" BROAD [] synonym: "activation of posterior gap gene transcription" NARROW [] synonym: "knirps activation" NARROW [] synonym: "stimulation of posterior gap gene transcription" NARROW [] synonym: "up regulation of posterior gap gene transcription" EXACT [] synonym: "up-regulation of posterior gap gene transcription" EXACT [] synonym: "upregulation of posterior gap gene transcription" EXACT [] is_a: GO:0044324 ! regulation of transcription involved in anterior/posterior axis specification is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0007359 ! posterior abdomen determination [Term] id: GO:0007361 name: establishment of posterior gap gene boundaries namespace: biological_process def: "Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007359 ! posterior abdomen determination [Term] id: GO:0007362 name: terminal region determination namespace: biological_process def: "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007363 name: positive regulation of terminal gap gene transcription namespace: biological_process def: "The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "activation of terminal gap gene" BROAD [] synonym: "activation of terminal gap gene transcription" NARROW [] synonym: "stimulation of terminal gap gene transcription" NARROW [] synonym: "up regulation of terminal gap gene transcription" EXACT [] synonym: "up-regulation of terminal gap gene transcription" EXACT [] synonym: "upregulation of terminal gap gene transcription" EXACT [] is_a: GO:0044324 ! regulation of transcription involved in anterior/posterior axis specification is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0007362 ! terminal region determination [Term] id: GO:0007364 name: establishment of terminal gap gene boundary namespace: biological_process def: "Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007362 ! terminal region determination [Term] id: GO:0007365 name: periodic partitioning namespace: biological_process def: "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma] comment: Note that examples of periodic partitions are tagmata, segments or parasegments. is_a: GO:0003002 ! regionalization relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0007366 name: periodic partitioning by pair rule gene namespace: biological_process def: "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] is_a: GO:0007365 ! periodic partitioning [Term] id: GO:0007367 name: segment polarity determination namespace: biological_process def: "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] is_a: GO:0007365 ! periodic partitioning [Term] id: GO:0007368 name: determination of left/right symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid] synonym: "determination of left/right asymmetry" EXACT [GOC:dph] is_a: GO:0009855 ! determination of bilateral symmetry [Term] id: GO:0007369 name: gastrulation namespace: biological_process def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] xref: Wikipedia:Gastrulation is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0007370 name: ventral furrow formation namespace: biological_process def: "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007371 name: ventral midline determination namespace: biological_process alt_id: GO:0007372 alt_id: GO:0007373 def: "The regionalization process in which the area where the ventral furrow will begin invagination is specified." [GOC:dph, GOC:isa_complete] synonym: "determination of anterior border of ventral midline" NARROW [] synonym: "determination of posterior border of ventral midline" NARROW [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007370 ! ventral furrow formation [Term] id: GO:0007374 name: posterior midgut invagination namespace: biological_process def: "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:08795694238] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007375 name: anterior midgut invagination namespace: biological_process def: "Internalization of the anterior midgut into the interior of the embryo." [ISBN:08795694238] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007376 name: cephalic furrow formation namespace: biological_process def: "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome." [ISBN:08795694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007377 name: germ-band extension namespace: biological_process def: "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007378 name: amnioserosa formation namespace: biological_process def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:08795694238] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007379 name: segment specification namespace: biological_process def: "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0035282 ! segmentation [Term] id: GO:0007380 name: specification of segmental identity, head namespace: biological_process def: "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0007379 ! segment specification relationship: part_of GO:0035287 ! head segmentation [Term] id: GO:0007381 name: specification of segmental identity, labial segment namespace: biological_process def: "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0007382 name: specification of segmental identity, maxillary segment namespace: biological_process def: "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0007383 name: specification of segmental identity, antennal segment namespace: biological_process def: "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035288 ! anterior head segmentation [Term] id: GO:0007384 name: specification of segmental identity, thorax namespace: biological_process def: "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0035292 ! specification of segmental identity, trunk [Term] id: GO:0007385 name: specification of segmental identity, abdomen namespace: biological_process def: "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0035292 ! specification of segmental identity, trunk [Term] id: GO:0007386 name: compartment pattern formation namespace: biological_process def: "The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "compartment specification" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern formation [Term] id: GO:0007387 name: anterior compartment pattern formation namespace: biological_process def: "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "anterior compartment pattern specification" RELATED [GOC:dph] is_a: GO:0007386 ! compartment pattern formation [Term] id: GO:0007388 name: posterior compartment specification namespace: biological_process def: "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0007386 ! compartment pattern formation [Term] id: GO:0007389 name: pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] synonym: "pattern biosynthesis" RELATED [] synonym: "pattern formation" RELATED [] is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007390 name: germ-band shortening namespace: biological_process def: "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] synonym: "germ-band retraction" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007391 name: dorsal closure namespace: biological_process def: "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007392 name: initiation of dorsal closure namespace: biological_process def: "Events that occur at the start of dorsal closure." [GOC:bf] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007393 name: dorsal closure, leading edge cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138] is_a: GO:0035028 ! leading edge cell fate determination relationship: part_of GO:0035029 ! dorsal closure, leading edge cell fate commitment [Term] id: GO:0007394 name: dorsal closure, elongation of leading edge cells namespace: biological_process def: "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0016476 ! regulation of embryonic cell shape is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007392 ! initiation of dorsal closure [Term] id: GO:0007395 name: dorsal closure, spreading of leading edge cells namespace: biological_process def: "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138] is_a: GO:0016477 ! cell migration relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007396 name: suture of dorsal opening namespace: biological_process def: "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007397 name: histogenesis and organogenesis namespace: biological_process def: "OBSOLETE. The generation of organized tissues or of whole organs." [GOC:ems] comment: This term was made obsolete because more appropriate terms were created. is_obsolete: true consider: GO:0009887 consider: GO:0009888 [Term] id: GO:0007398 name: ectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007399 name: nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] synonym: "pan-neural process" RELATED [] is_a: GO:0048731 ! system development [Term] id: GO:0007400 name: neuroblast fate determination namespace: biological_process alt_id: GO:0007408 alt_id: GO:0043347 alt_id: GO:0043348 def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] synonym: "neuroblast cell fate determination" EXACT [] synonym: "neuroblast identity determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0014017 ! neuroblast fate commitment [Term] id: GO:0007401 name: pan-neural process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because its meaning is ambiguous. is_obsolete: true consider: GO:0007399 consider: GO:0050877 [Term] id: GO:0007402 name: ganglion mother cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0001709 ! cell fate determination [Term] id: GO:0007403 name: glial cell fate determination namespace: biological_process alt_id: GO:0043361 def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0021781 ! glial cell fate commitment [Term] id: GO:0007405 name: neuroblast proliferation namespace: biological_process alt_id: GO:0043349 alt_id: GO:0043350 def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0007406 name: negative regulation of neuroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai] synonym: "down regulation of neuroblast proliferation" EXACT [] synonym: "down-regulation of neuroblast proliferation" EXACT [] synonym: "downregulation of neuroblast proliferation" EXACT [] synonym: "inhibition of neuroblast proliferation" NARROW [] synonym: "suppression of neuroblast proliferation" EXACT [] is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation relationship: negatively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0007407 name: neuroblast activation namespace: biological_process alt_id: GO:0043351 alt_id: GO:0043352 def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001775 ! cell activation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0007409 name: axonogenesis namespace: biological_process alt_id: GO:0007410 def: "Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:jid, ISBN:0198506732] synonym: "axon growth" NARROW [] synonym: "neuron long process generation" EXACT systematic_synonym [] is_a: GO:0048812 ! neuron projection morphogenesis relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation [Term] id: GO:0007411 name: axon guidance namespace: biological_process alt_id: GO:0008040 def: "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] synonym: "axon chemotaxis" RELATED [GOC:curators] synonym: "axon growth cone guidance" NARROW [] synonym: "axon pathfinding" EXACT [GOC:mah] xref: Reactome:1253128 "Axon guidance" xref: Reactome:1280063 "Axon guidance" xref: Reactome:1298955 "Axon guidance" xref: Reactome:1326633 "Axon guidance" xref: Reactome:1352746 "Axon guidance" xref: Reactome:1372957 "Axon guidance" xref: Reactome:1392973 "Axon guidance" xref: Reactome:1417453 "Axon guidance" xref: Reactome:1450546 "Axon guidance" xref: Reactome:1471063 "Axon guidance" xref: Reactome:1483079 "Axon guidance" xref: Reactome:1521309 "Axon guidance" xref: Reactome:1526802 "Axon guidance" xref: Reactome:1532528 "Axon guidance" xref: Reactome:422475 "Axon guidance" xref: Wikipedia:Axon_guidance is_a: GO:0006935 ! chemotaxis relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007412 name: axon target recognition namespace: biological_process def: "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] is_a: GO:0007154 ! cell communication relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007413 name: axonal fasciculation namespace: biological_process def: "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] synonym: "fasciculation of neuron" RELATED [] is_a: GO:0008038 ! neuron recognition relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007414 name: axonal defasciculation namespace: biological_process def: "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X] synonym: "defasciculation of neuron" RELATED [] is_a: GO:0008038 ! neuron recognition relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007415 name: defasciculation of motor neuron axon namespace: biological_process def: "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] is_a: GO:0007414 ! axonal defasciculation [Term] id: GO:0007416 name: synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah] synonym: "synapse biogenesis" EXACT [GOC:mah] synonym: "synaptogenesis" EXACT [GOC:mah] xref: Wikipedia:Synaptogenesis is_a: GO:0050808 ! synapse organization is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007417 name: central nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] synonym: "CNS development" EXACT [] xref: Wikipedia:Neural_development is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007418 name: ventral midline development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007419 name: ventral cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] is_a: GO:0048513 ! organ development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007420 name: brain development namespace: biological_process def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] is_a: GO:0048513 ! organ development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007421 name: stomatogastric nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007422 name: peripheral nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007423 name: sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] synonym: "sense organ development" EXACT [GOC:dph] is_a: GO:0048513 ! organ development [Term] id: GO:0007424 name: open tracheal system development namespace: biological_process def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'. is_a: GO:0060541 ! respiratory system development [Term] id: GO:0007425 name: epithelial cell fate determination, open tracheal system namespace: biological_process alt_id: GO:0046846 def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940] synonym: "tracheal cell fate determination" BROAD [] synonym: "tracheal epithelial cell fate determination" EXACT [] synonym: "tracheal placode cell fate determination" RELATED [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007426 name: tracheal outgrowth, open tracheal system namespace: biological_process def: "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007427 name: epithelial cell migration, open tracheal system namespace: biological_process def: "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "tracheal cell migration" BROAD [] synonym: "tracheal epithelial cell migration" RELATED [] is_a: GO:0010631 ! epithelial cell migration relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007428 name: primary branching, open tracheal system namespace: biological_process def: "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "primary tracheal branching" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007429 name: secondary branching, open tracheal system namespace: biological_process def: "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "secondary tracheal branching" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007430 name: terminal branching, open tracheal system namespace: biological_process def: "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "terminal branching of trachea, cytoplasmic projection extension" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007431 name: salivary gland development namespace: biological_process def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] is_a: GO:0048732 ! gland development relationship: part_of GO:0035272 ! exocrine system development [Term] id: GO:0007432 name: salivary gland boundary specification namespace: biological_process def: "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] synonym: "salivary gland determination" EXACT [] is_a: GO:0010160 ! formation of organ boundary relationship: part_of GO:0007431 ! salivary gland development [Term] id: GO:0007433 name: larval salivary gland boundary specification namespace: biological_process def: "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] synonym: "larval salivary gland determination" BROAD [GOC:tb] is_a: GO:0007432 ! salivary gland boundary specification relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007434 name: adult salivary gland boundary specification namespace: biological_process def: "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] synonym: "larval salivary gland determination" BROAD [GOC:tb] is_a: GO:0007432 ! salivary gland boundary specification [Term] id: GO:0007435 name: salivary gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0007431 ! salivary gland development [Term] id: GO:0007436 name: larval salivary gland morphogenesis namespace: biological_process def: "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] is_a: GO:0007435 ! salivary gland morphogenesis is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007437 name: adult salivary gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the adult salivary gland are generated and organized." [GOC:go_curators] is_a: GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0007438 name: oenocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] is_a: GO:0048468 ! cell development relationship: part_of GO:0001742 ! oenocyte differentiation [Term] id: GO:0007439 name: ectodermal digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators] synonym: "ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0007440 name: foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0007441 name: anterior midgut (ectodermal) morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized." [GOC:go_curators] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis [Term] id: GO:0007442 name: hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0007443 name: Malpighian tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0061333 ! renal tubule morphogenesis relationship: part_of GO:0048619 ! embryonic hindgut morphogenesis relationship: part_of GO:0072002 ! Malpighian tubule development [Term] id: GO:0007444 name: imaginal disc development namespace: biological_process def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] is_a: GO:0048513 ! organ development [Term] id: GO:0007445 name: determination of imaginal disc primordium namespace: biological_process def: "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment." [ISBN:0879694238] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007446 name: imaginal disc growth namespace: biological_process def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387] is_a: GO:0035265 ! organ growth is_a: GO:0048589 ! developmental growth relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007447 name: imaginal disc pattern formation namespace: biological_process def: "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007448 name: anterior/posterior pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009952 ! anterior/posterior pattern formation [Term] id: GO:0007449 name: proximal/distal pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0007450 name: dorsal/ventral pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] synonym: "dorsal-ventral pattern formation, imaginal disc" EXACT [GOC:mah] synonym: "dorsoventral pattern formation, imaginal disc" EXACT [GOC:mah] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0007451 name: dorsal/ventral lineage restriction, imaginal disc namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] synonym: "dorsal-ventral lineage restriction, imaginal disc" EXACT [GOC:mah] synonym: "dorsoventral lineage restriction, imaginal disc" EXACT [GOC:mah] is_a: GO:0035161 ! imaginal disc lineage restriction relationship: part_of GO:0007450 ! dorsal/ventral pattern formation, imaginal disc [Term] id: GO:0007453 name: clypeo-labral disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus." [GOC:bf, ISBN:0879694238] synonym: "clypeo-labral disc metamorphosis" EXACT [] synonym: "morphogenesis of structures derived from the clypeo-labral disc" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0007454 name: labial disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] synonym: "labial disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035217 ! labial disc development [Term] id: GO:0007455 name: eye-antennal disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] synonym: "eye-antennal disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0007458 name: progression of morphogenetic furrow involved in compound eye morphogenesis namespace: biological_process def: "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] synonym: "progression of morphogenetic furrow during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0007460 name: R8 cell fate commitment namespace: biological_process alt_id: GO:0007461 def: "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883] synonym: "restriction of R8 fate" EXACT [] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0045465 ! R8 cell differentiation [Term] id: GO:0007462 name: R1/R6 cell fate commitment namespace: biological_process def: "The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0048052 ! R1/R6 cell differentiation [Term] id: GO:0007463 name: R2/R5 cell fate commitment namespace: biological_process def: "The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0048054 ! R2/R5 cell differentiation [Term] id: GO:0007464 name: R3/R4 cell fate commitment namespace: biological_process def: "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity relationship: part_of GO:0048056 ! R3/R4 cell differentiation [Term] id: GO:0007465 name: R7 cell fate commitment namespace: biological_process def: "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0045466 ! R7 cell differentiation [Term] id: GO:0007468 name: regulation of rhodopsin gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression relationship: part_of GO:0042461 ! photoreceptor cell development [Term] id: GO:0007469 name: antennal development namespace: biological_process def: "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0007470 name: prothoracic disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] synonym: "prothoracic disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0035219 ! prothoracic disc development [Term] id: GO:0007471 name: prothoracic morphogenesis namespace: biological_process def: "OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized." [GOC:jid] comment: This term was made obsolete because it does not stipulate which anatomical part is involved in the process. is_obsolete: true consider: GO:0007470 [Term] id: GO:0007472 name: wing disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] synonym: "wing disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0007473 name: wing disc proximal/distal pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf] is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc is_a: GO:0035222 ! wing disc pattern formation [Term] id: GO:0007474 name: imaginal disc-derived wing vein specification namespace: biological_process def: "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] synonym: "wing vein specification" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0007475 name: apposition of dorsal and ventral imaginal disc-derived wing surfaces namespace: biological_process def: "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] synonym: "apposition of dorsal and ventral wing surfaces" EXACT [] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0008587 ! imaginal disc-derived wing margin morphogenesis [Term] id: GO:0007476 name: imaginal disc-derived wing morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] synonym: "wing morphogenesis" EXACT [] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis relationship: part_of GO:0007472 ! wing disc morphogenesis [Term] id: GO:0007477 name: notum development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0007478 name: leg disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] synonym: "leg disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035218 ! leg disc development [Term] id: GO:0007479 name: leg disc proximal/distal pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc is_a: GO:0035223 ! leg disc pattern formation [Term] id: GO:0007480 name: imaginal disc-derived leg morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0035109 ! imaginal disc-derived limb morphogenesis is_a: GO:0035110 ! leg morphogenesis is_a: GO:0035127 ! post-embryonic limb morphogenesis relationship: part_of GO:0007478 ! leg disc morphogenesis [Term] id: GO:0007481 name: haltere disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] synonym: "haltere disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035216 ! haltere disc development [Term] id: GO:0007482 name: haltere development namespace: biological_process def: "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] is_a: GO:0048737 ! imaginal disc-derived appendage development relationship: part_of GO:0035216 ! haltere disc development [Term] id: GO:0007483 name: genital disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] synonym: "genital disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007484 name: imaginal disc-derived genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "genital development" BROAD [] is_a: GO:0048806 ! genitalia development relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007485 name: imaginal disc-derived male genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "male genital development" BROAD [] is_a: GO:0007484 ! imaginal disc-derived genitalia development [Term] id: GO:0007486 name: imaginal disc-derived female genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "female genital development" BROAD [] is_a: GO:0007484 ! imaginal disc-derived genitalia development is_a: GO:0030540 ! female genitalia development [Term] id: GO:0007487 name: analia development namespace: biological_process def: "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007488 name: histoblast morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] synonym: "histoblast metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0007489 name: maintenance of imaginal histoblast diploidy namespace: biological_process def: "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells." [GOC:bf, ISBN:0879694238] is_a: GO:0045596 ! negative regulation of cell differentiation relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007490 name: tergite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jid, http://www.earthlife.net] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007491 name: sternite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment." [GOC:jid, http://www.earthlife.net] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007492 name: endoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007493 name: endodermal cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] comment: Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'. synonym: "endoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001711 ! endodermal cell fate commitment [Term] id: GO:0007494 name: midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] is_a: GO:0048565 ! digestive tract development [Term] id: GO:0007495 name: visceral mesoderm-endoderm interaction involved in midgut development namespace: biological_process def: "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut." [GOC:dph, GOC:isa_complete] synonym: "visceral mesoderm/endoderm interaction" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007496 name: anterior midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007497 name: posterior midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007498 name: mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007499 name: ectoderm and mesoderm interaction namespace: biological_process def: "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete] synonym: "ectoderm/mesoderm interaction" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0007500 name: mesodermal cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'. synonym: "mesoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001710 ! mesodermal cell fate commitment [Term] id: GO:0007501 name: mesodermal cell fate specification namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] comment: Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'. synonym: "mesoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001710 ! mesodermal cell fate commitment [Term] id: GO:0007502 name: digestive tract mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism." [GOC:ai] is_a: GO:0009888 ! tissue development relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0007503 name: fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089] is_a: GO:0048513 ! organ development [Term] id: GO:0007504 name: larval fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life." [GOC:bf, ISBN:0879694238] is_a: GO:0007503 ! fat body development is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007505 name: adult fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body." [GOC:bf, ISBN:0879694238] is_a: GO:0007503 ! fat body development [Term] id: GO:0007506 name: gonadal mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007498 ! mesoderm development relationship: part_of GO:0008406 ! gonad development [Term] id: GO:0007507 name: heart development namespace: biological_process alt_id: GO:0007511 def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] synonym: "cardiac development" RELATED [] synonym: "dorsal vessel development" NARROW [] xref: Wikipedia:Heart_development is_a: GO:0048513 ! organ development relationship: part_of GO:0072358 ! cardiovascular system development [Term] id: GO:0007508 name: larval heart development namespace: biological_process def: "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:08779694238] is_a: GO:0007507 ! heart development is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007509 name: mesoderm migration involved in gastrulation namespace: biological_process def: "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete] is_a: GO:0090130 ! tissue migration relationship: part_of GO:0001707 ! mesoderm formation [Term] id: GO:0007510 name: cardioblast cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0060913 ! cardiac cell fate determination relationship: part_of GO:0042684 ! cardioblast cell fate commitment [Term] id: GO:0007512 name: adult heart development namespace: biological_process def: "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure." [GOC:bf] synonym: "adult cardiac development" RELATED [] is_a: GO:0007507 ! heart development [Term] id: GO:0007513 name: pericardial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized features of a pericardial cell. In insects, pericardial cells are loosely arranged non-myogenic cells that flank the cardioblasts and probably act in the filtration of hemolymph." [GOC:bf, PMID:12435360] is_a: GO:0035051 ! cardiac cell differentiation [Term] id: GO:0007514 name: garland cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a garland cell, a small group of nephrocytes which take up waste materials from the hemolymph by endocytosis." [PMID:7588884] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007515 name: lymph gland development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system." [GOC:jid] comment: This term was made obsolete because it was wrongly defined. is_obsolete: true consider: GO:0048535 consider: GO:0048542 [Term] id: GO:0007516 name: hemocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] synonym: "arthropod blood cell development" EXACT [] is_a: GO:0048468 ! cell development relationship: part_of GO:0042386 ! hemocyte differentiation [Term] id: GO:0007517 name: muscle organ development namespace: biological_process def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048513 ! organ development is_a: GO:0061061 ! muscle structure development [Term] id: GO:0007518 name: myoblast cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0048625 ! myoblast cell fate commitment [Term] id: GO:0007519 name: skeletal muscle tissue development namespace: biological_process alt_id: GO:0048637 def: "The developmental sequence of events leading to the formation of adult muscle that occurs in the anima. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] synonym: "myogenesis" RELATED [] is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0060538 ! skeletal muscle organ development [Term] id: GO:0007520 name: myoblast fusion namespace: biological_process def: "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0000768 ! syncytium formation by plasma membrane fusion relationship: part_of GO:0014902 ! myotube differentiation [Term] id: GO:0007521 name: muscle cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0042693 ! muscle cell fate commitment [Term] id: GO:0007522 name: visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0007517 ! muscle organ development [Term] id: GO:0007523 name: larval visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007522 ! visceral muscle development is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007524 name: adult visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007522 ! visceral muscle development [Term] id: GO:0007525 name: somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] is_a: GO:0061061 ! muscle structure development [Term] id: GO:0007526 name: larval somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007525 ! somatic muscle development is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007527 name: adult somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007525 ! somatic muscle development [Term] id: GO:0007528 name: neuromuscular junction development namespace: biological_process def: "The process whose specific outcome is the progression of the neuromuscular junction over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0050808 ! synapse organization relationship: part_of GO:0048741 ! skeletal muscle fiber development [Term] id: GO:0007529 name: establishment of synaptic specificity at neuromuscular junction namespace: biological_process def: "The biological process in which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete] is_a: GO:0050808 ! synapse organization relationship: part_of GO:0007528 ! neuromuscular junction development [Term] id: GO:0007530 name: sex determination namespace: biological_process def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Sex-determination_system is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007531 name: mating type determination namespace: biological_process def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [http://www.biology-text.com/] is_a: GO:0007530 ! sex determination is_a: GO:0045165 ! cell fate commitment is_a: GO:0048610 ! cellular process involved in reproduction [Term] id: GO:0007532 name: regulation of transcription, mating-type specific namespace: biological_process def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription." [GOC:go_curators] synonym: "mating-type specific transcriptional control" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0007531 ! mating type determination [Term] id: GO:0007533 name: mating type switching namespace: biological_process def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492] synonym: "mating type switching and recombination" RELATED [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0007531 ! mating type determination is_a: GO:0022413 ! reproductive process in single-celled organism [Term] id: GO:0007534 name: gene conversion at mating-type locus namespace: biological_process def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:9928492] is_a: GO:0006312 ! mitotic recombination is_a: GO:0035822 ! gene conversion is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007533 ! mating type switching [Term] id: GO:0007535 name: donor selection namespace: biological_process def: "The process that determines which donor locus a cell uses, in preference to another, in mating type switching." [GOC:mah, PMID:9928492] synonym: "donor preference" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0007533 ! mating type switching [Term] id: GO:0007536 name: activation of recombination (HML) namespace: biological_process def: "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] is_a: GO:0007535 ! donor selection is_a: GO:0045911 ! positive regulation of DNA recombination [Term] id: GO:0007537 name: inactivation of recombination (HML) namespace: biological_process def: "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] is_a: GO:0007535 ! donor selection is_a: GO:0045910 ! negative regulation of DNA recombination [Term] id: GO:0007538 name: primary sex determination namespace: biological_process def: "The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007539 name: primary sex determination, soma namespace: biological_process def: "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems] is_a: GO:0007538 ! primary sex determination relationship: part_of GO:0018993 ! somatic sex determination [Term] id: GO:0007540 name: sex determination, establishment of X:A ratio namespace: biological_process def: "The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007539 ! primary sex determination, soma [Term] id: GO:0007541 name: sex determination, primary response to X:A ratio namespace: biological_process def: "The developmental process in which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007539 ! primary sex determination, soma [Term] id: GO:0007542 name: primary sex determination, germ-line namespace: biological_process def: "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line." [GOC:ems] is_a: GO:0007538 ! primary sex determination relationship: part_of GO:0018992 ! germ-line sex determination [Term] id: GO:0007543 name: sex determination, somatic-gonadal interaction namespace: biological_process def: "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism." [GOC:isa_complete] synonym: "sex determination, somatic/gonadal interaction" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007542 ! primary sex determination, germ-line [Term] id: GO:0007545 name: processes downstream of sex determination signal namespace: biological_process def: "The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways." [GOC:mah] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007546 name: somatic processes downstream of sex determination signal namespace: biological_process def: "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways." [GOC:ems] is_a: GO:0007545 ! processes downstream of sex determination signal [Term] id: GO:0007547 name: germ-line processes downstream of sex determination signal namespace: biological_process def: "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways." [GOC:ems] is_a: GO:0007545 ! processes downstream of sex determination signal relationship: part_of GO:0018992 ! germ-line sex determination [Term] id: GO:0007548 name: sex differentiation namespace: biological_process def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] xref: Wikipedia:Sexual_differentiation is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007549 name: dosage compensation namespace: biological_process def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577] xref: Wikipedia:Dosage_compensation is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0007550 name: establishment of dosage compensation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete] comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. is_obsolete: true consider: GO:0007549 [Term] id: GO:0007551 name: maintenance of dosage compensation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete] comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. is_obsolete: true consider: GO:0007549 [Term] id: GO:0007552 name: metamorphosis namespace: biological_process alt_id: GO:0046698 alt_id: GO:0046699 def: "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: Wikipedia:Metamorphosis is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0007553 name: regulation of ecdysteroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "regulation of ecdysteroid metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0048580 ! regulation of post-embryonic development relationship: regulates GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0007554 name: regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "regulation of ecdysteroid anabolism" EXACT [] synonym: "regulation of ecdysteroid biosynthesis" EXACT [] synonym: "regulation of ecdysteroid formation" EXACT [] synonym: "regulation of ecdysteroid synthesis" EXACT [] is_a: GO:0007553 ! regulation of ecdysteroid metabolic process is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process relationship: regulates GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0007555 name: regulation of ecdysteroid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell or group of cells." [GOC:go_curators] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0045457 ! ecdysteroid secretion [Term] id: GO:0007556 name: regulation of juvenile hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone metabolism" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process relationship: part_of GO:0002165 ! instar larval or pupal development relationship: regulates GO:0006716 ! juvenile hormone metabolic process [Term] id: GO:0007557 name: regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone anabolism" EXACT [] synonym: "regulation of juvenile hormone biosynthesis" EXACT [] synonym: "regulation of juvenile hormone formation" EXACT [] synonym: "regulation of juvenile hormone synthesis" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0006718 ! juvenile hormone biosynthetic process [Term] id: GO:0007558 name: regulation of juvenile hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0045443 ! juvenile hormone secretion [Term] id: GO:0007559 name: histolysis namespace: biological_process def: "The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma] xref: Wikipedia:Histolysis is_a: GO:0016271 ! tissue death relationship: part_of GO:0009888 ! tissue development [Term] id: GO:0007560 name: imaginal disc morphogenesis namespace: biological_process alt_id: GO:0007452 def: "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] synonym: "imaginal disc metamorphosis" EXACT [] is_a: GO:0048563 ! post-embryonic organ morphogenesis relationship: part_of GO:0007444 ! imaginal disc development relationship: part_of GO:0007552 ! metamorphosis relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis [Term] id: GO:0007561 name: imaginal disc eversion namespace: biological_process def: "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0007562 name: eclosion namespace: biological_process def: "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461] xref: Wikipedia:Pupa#Emergence is_a: GO:0071684 ! organism emergence from protective structure relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007563 name: regulation of eclosion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0007562 ! eclosion [Term] id: GO:0007564 name: regulation of chitin-based cuticle tanning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] synonym: "regulation of cuticle hardening" NARROW [] synonym: "regulation of cuticle tanning" EXACT [] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0007593 ! chitin-based cuticle tanning [Term] id: GO:0007565 name: female pregnancy namespace: biological_process def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] synonym: "carrying of young" RELATED [] synonym: "gestation" EXACT [] xref: Wikipedia:Gestation is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0007566 name: embryo implantation namespace: biological_process def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, http://www.medterms.com] synonym: "blastocyst implantation" EXACT [] is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007275 ! multicellular organismal development relationship: part_of GO:0007565 ! female pregnancy [Term] id: GO:0007567 name: parturition namespace: biological_process def: "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "egg laying" NARROW [] synonym: "giving birth" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0007568 name: aging namespace: biological_process alt_id: GO:0016280 def: "The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility." [GOC:dph, GOC:ems] subset: goslim_generic synonym: "ageing" EXACT [] xref: Wikipedia:Aging is_a: GO:0032502 ! developmental process [Term] id: GO:0007569 name: cell aging namespace: biological_process def: "Progression of the cell from its inception to the end of its lifespan." [GOC:jh, PMID:12044934] synonym: "cell ageing" EXACT [] is_a: GO:0007568 ! aging is_a: GO:0009987 ! cellular process [Term] id: GO:0007570 name: age dependent accumulation of genetic damage namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0001301 [Term] id: GO:0007571 name: age-dependent general metabolic decline namespace: biological_process def: "A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis." [GOC:jh, GOC:mah, PMID:9891807] synonym: "age-dependent decreased translational activity" NARROW [] synonym: "age-dependent increased protein content" NARROW [] synonym: "age-dependent yeast cell size increase" RELATED [] synonym: "nucleolar size increase" NARROW [] is_a: GO:0032502 ! developmental process relationship: part_of GO:0007568 ! aging [Term] id: GO:0007572 name: age dependent decreased translational activity namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0007571 [Term] id: GO:0007573 name: age dependent increased protein content namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0007571 [Term] id: GO:0007574 name: cell aging (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell." [GOC:sgd_curators] comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. is_obsolete: true replaced_by: GO:0007569 [Term] id: GO:0007575 name: nucleolar size increase namespace: biological_process def: "OBSOLETE. The process of nucleolar expansion." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0007571 consider: GO:0007576 [Term] id: GO:0007576 name: nucleolar fragmentation namespace: biological_process alt_id: GO:0046616 def: "The cell aging process that results in the nucleolus breaking down into fragments." [GOC:mah, PMID:9271578] synonym: "nucleolar size increase" RELATED [] is_a: GO:0007000 ! nucleolus organization relationship: part_of GO:0007569 ! cell aging [Term] id: GO:0007577 name: autophagic death (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA." [GOC:sgd_curators] comment: This term was made obsolete because a more correct term has been created. is_obsolete: true consider: GO:0048102 [Term] id: GO:0007578 name: aging dependent sterility (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes." [GOC:sgd_curators] comment: This term was made obsolete because it reflected a trait or phenotype. is_obsolete: true consider: GO:0030466 [Term] id: GO:0007579 name: senescence factor accumulation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jh] comment: This term was made obsolete because it does not represent a process. is_obsolete: true [Term] id: GO:0007580 name: extrachromosomal circular DNA accumulation involved in cell aging namespace: biological_process def: "Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication." [GOC:jh, PMID:9891807] comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. synonym: "extrachromosomal circular DNA accumulation during cell ageing" RELATED [] synonym: "extrachromosomal circular DNA accumulation during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging [Term] id: GO:0007581 name: age-dependent yeast cell size increase namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0007571 [Term] id: GO:0007583 name: killer activity namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is ambiguous; 'killer activity' could refer to several different processes. is_obsolete: true consider: GO:0042267 [Term] id: GO:0007584 name: response to nutrient namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] subset: gosubset_prok synonym: "nutritional response pathway" NARROW [] synonym: "response to nutrients" EXACT [] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0007585 name: respiratory gaseous exchange namespace: biological_process def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "breathing" BROAD [] synonym: "respiration" BROAD [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007586 name: digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir xref: Wikipedia:Digestion is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007587 name: sugar utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sugar sources, usually glucose, and then activates genes to scavenge the last traces of the primary sugar source and to transport and metabolize alternate sugar sources. The utilization process begins when the cell or organism detects sugar levels, includes the activation of genes whose products detect, transport or metabolize sugars, and ends when the sugar is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] is_a: GO:0008150 ! biological_process [Term] id: GO:0007588 name: excretion namespace: biological_process def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023] subset: goslim_pir xref: Wikipedia:Excretion is_a: GO:0003008 ! system process is_a: GO:0046903 ! secretion [Term] id: GO:0007589 name: body fluid secretion namespace: biological_process def: "The controlled release of a fluid by a cell or group of cells in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0046903 ! secretion is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007590 name: fat body metabolic process (sensu Insecta) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents metabolism within the fat body not of the fat body. is_obsolete: true consider: GO:0008152 consider: GO:0015032 [Term] id: GO:0007591 name: molting cycle, chitin-based cuticle namespace: biological_process def: "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] synonym: "chitin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0018988 ! molting cycle, protein-based cuticle [Term] id: GO:0007592 name: protein-based cuticle development namespace: biological_process def: "Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu] synonym: "protein-based cuticle anabolism" EXACT [] synonym: "protein-based cuticle biosynthetic process" EXACT [] synonym: "protein-based cuticle formation" EXACT [] synonym: "protein-based cuticle synthesis" EXACT [] is_a: GO:0042335 ! cuticle development [Term] id: GO:0007593 name: chitin-based cuticle tanning namespace: biological_process alt_id: GO:0045452 def: "The cross-linking of chitin and other cuticle proteins, rendering them insoluble and hardening the cuticle. This process generally darkens the color of the cuticle." [GOC:bf, GOC:jid, GOC:mtg_sensu] synonym: "cuticle hardening" NARROW [] is_a: GO:0021700 ! developmental maturation is_a: GO:0040006 ! protein-based cuticle attachment to epithelium relationship: part_of GO:0008365 ! adult chitin-based cuticle development [Term] id: GO:0007594 name: puparial adhesion namespace: biological_process def: "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma] synonym: "puparial glue" RELATED [] is_a: GO:0022609 ! multicellular organism adhesion to substrate relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0007595 name: lactation namespace: biological_process def: "The secretion of milk by the mammary gland." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Lactation is_a: GO:0007589 ! body fluid secretion is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0007596 name: blood coagulation namespace: biological_process def: "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "blood clotting" EXACT [] xref: Reactome:109582 "Hemostasis" xref: Reactome:1253227 "Hemostasis" xref: Reactome:1253256 "Common Pathway" xref: Reactome:1253257 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:1280165 "Hemostasis" xref: Reactome:1280192 "Common Pathway" xref: Reactome:1280193 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:1299036 "Hemostasis" xref: Reactome:1299064 "Common Pathway" xref: Reactome:1299065 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:1326740 "Hemostasis" xref: Reactome:1326768 "Common Pathway" xref: Reactome:1326769 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:1352844 "Hemostasis" xref: Reactome:1352872 "Common Pathway" xref: Reactome:1352873 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:1373063 "Hemostasis" xref: Reactome:1373078 "Common Pathway" xref: Reactome:1373079 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:1393079 "Hemostasis" xref: Reactome:1393093 "Common Pathway" xref: Reactome:1393094 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:140875 "Common Pathway" xref: Reactome:140877 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:1417555 "Hemostasis" xref: Reactome:1417579 "Common Pathway" xref: Reactome:1417580 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:1450647 "Hemostasis" xref: Reactome:1450669 "Common Pathway" xref: Reactome:1450670 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:1471138 "Hemostasis" xref: Reactome:1483147 "Hemostasis" xref: Reactome:1497025 "Hemostasis" xref: Reactome:1514412 "Hemostasis" xref: Reactome:1521095 "Hemostasis" xref: Reactome:1526986 "Hemostasis" xref: Reactome:1532722 "Hemostasis" xref: Reactome:1536121 "Hemostasis" xref: Reactome:1538081 "Hemostasis" xref: Reactome:1539375 "Hemostasis" xref: Reactome:1540377 "Hemostasis" xref: Wikipedia:Coagulation is_a: GO:0007599 ! hemostasis is_a: GO:0050817 ! coagulation relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0007597 name: blood coagulation, intrinsic pathway namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde] comment: See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'. xref: Reactome:1253292 "Intrinsic Pathway" xref: Reactome:1280229 "Intrinsic Pathway" xref: Reactome:1299090 "Intrinsic Pathway" xref: Reactome:1326805 "Intrinsic Pathway" xref: Reactome:1352907 "Intrinsic Pathway" xref: Reactome:1373111 "Intrinsic Pathway" xref: Reactome:1393129 "Intrinsic Pathway" xref: Reactome:140837 "Intrinsic Pathway" xref: Reactome:1417616 "Intrinsic Pathway" xref: Reactome:1450707 "Intrinsic Pathway" is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation [Term] id: GO:0007598 name: blood coagulation, extrinsic pathway namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde] comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. xref: Reactome:1253258 "Extrinsic Pathway" xref: Reactome:1280194 "Extrinsic Pathway" xref: Reactome:1326770 "Extrinsic Pathway" xref: Reactome:1352874 "Extrinsic Pathway" xref: Reactome:1373080 "Extrinsic Pathway" xref: Reactome:1393095 "Extrinsic Pathway" xref: Reactome:140834 "Extrinsic Pathway" xref: Reactome:1417581 "Extrinsic Pathway" xref: Reactome:1450671 "Extrinsic Pathway" is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation [Term] id: GO:0007599 name: hemostasis namespace: biological_process def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Hemostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007600 name: sensory perception namespace: biological_process def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph] xref: Wikipedia:Perception is_a: GO:0050877 ! neurological system process [Term] id: GO:0007601 name: visual perception namespace: biological_process def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] synonym: "sense of sight" EXACT [] synonym: "sensory visual perception" EXACT [] synonym: "vision" EXACT [] xref: Wikipedia:Visual_perception is_a: GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0007602 name: phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] subset: gosubset_prok synonym: "opsin" RELATED [] synonym: "phototransduction, visible light, light adaptation" NARROW [] synonym: "phototrophin mediated phototransduction" NARROW [] xref: Wikipedia:Visual_phototransduction is_a: GO:0007165 ! signal transduction is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0007603 name: phototransduction, visible light namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0007602 ! phototransduction is_a: GO:0009584 ! detection of visible light [Term] id: GO:0007604 name: phototransduction, UV namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "phototransduction, ultraviolet light" EXACT [] synonym: "phototransduction, ultraviolet radiation" EXACT [] synonym: "phototransduction, UV light" EXACT [] synonym: "phototransduction, UV radiation" EXACT [] synonym: "UV-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction is_a: GO:0009589 ! detection of UV is_a: GO:0034644 ! cellular response to UV [Term] id: GO:0007605 name: sensory perception of sound namespace: biological_process def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] synonym: "hearing" EXACT [] synonym: "perception of sound" EXACT [] xref: Wikipedia:Hearing_(sense) is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0007606 name: sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemosensory perception" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0007607 name: taste perception namespace: biological_process def: "OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal." [GOC:jl, ISBN:0395825172] comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. is_obsolete: true consider: GO:0050909 consider: GO:0050912 [Term] id: GO:0007608 name: sensory perception of smell namespace: biological_process def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] synonym: "olfaction" EXACT [] synonym: "scent perception" EXACT [] synonym: "sense of smell" EXACT [] synonym: "smell perception" EXACT [] xref: Wikipedia:Olfaction is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0007610 name: behavior namespace: biological_process def: "The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:ems, ISBN:0395448956] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: goslim_plant subset: gosubset_prok subset: high_level_annotation_qc synonym: "behavioral response to stimulus" EXACT [] synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] xref: Wikipedia:Behavior is_a: GO:0050896 ! response to stimulus [Term] id: GO:0007611 name: learning or memory namespace: biological_process def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] is_a: GO:0007610 ! behavior is_a: GO:0050890 ! cognition [Term] id: GO:0007612 name: learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: Wikipedia:Learning is_a: GO:0007611 ! learning or memory [Term] id: GO:0007613 name: memory namespace: biological_process def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] xref: Wikipedia:Memory is_a: GO:0007611 ! learning or memory [Term] id: GO:0007614 name: short-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Short-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007615 name: anesthesia-resistant memory namespace: biological_process def: "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] is_a: GO:0007613 ! memory [Term] id: GO:0007616 name: long-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Long-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007617 name: mating behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] synonym: "mating behaviour" EXACT [] xref: Wikipedia:Mating_behaviour is_a: GO:0019098 ! reproductive behavior is_a: GO:0051705 ! behavioral interaction between organisms relationship: part_of GO:0007618 ! mating [Term] id: GO:0007618 name: mating namespace: biological_process def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [ISBN:0387520546] is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0007619 name: courtship behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] synonym: "courtship behaviour" EXACT [] is_a: GO:0007617 ! mating behavior [Term] id: GO:0007620 name: copulation namespace: biological_process def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0007618 ! mating [Term] id: GO:0007621 name: negative regulation of female receptivity namespace: biological_process def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827] synonym: "down regulation of female receptivity" EXACT [] synonym: "down-regulation of female receptivity" EXACT [] synonym: "downregulation of female receptivity" EXACT [] synonym: "inhibition of female receptivity" NARROW [] is_a: GO:0045924 ! regulation of female receptivity [Term] id: GO:0007622 name: rhythmic behavior namespace: biological_process def: "The specific actions or reactions of an organism that recur with measured regularity." [GOC:jl] synonym: "rhythmic behavioral response to stimulus" EXACT [] synonym: "rhythmic behaviour" EXACT [] synonym: "rhythmic behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007623 name: circadian rhythm namespace: biological_process alt_id: GO:0050895 def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] subset: gosubset_prok synonym: "circadian process" EXACT [] synonym: "circadian response" RELATED [] synonym: "response to circadian rhythm" RELATED [] xref: Wikipedia:Circadian_rhythm is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007624 name: ultradian rhythm namespace: biological_process def: "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours." [GOC:jl, PMID:19708721] is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007625 name: grooming behavior namespace: biological_process def: "The specific actions or reactions of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl] synonym: "grooming behaviour" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007626 name: locomotory behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] subset: gosubset_prok synonym: "behavior via locomotion" EXACT [] synonym: "locomotion in response to stimulus" EXACT [] synonym: "locomotory behavioral response to stimulus" EXACT [] synonym: "locomotory behaviour" EXACT [] synonym: "locomotory behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007627 name: larval behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects." [GOC:ai, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. is_obsolete: true replaced_by: GO:0030537 [Term] id: GO:0007628 name: adult walking behavior namespace: biological_process def: "The actions or reactions of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, ISBN:0198606907] synonym: "adult walking behaviour" EXACT [] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007629 name: flight behavior namespace: biological_process def: "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] synonym: "flight behaviour" EXACT [] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007630 name: jump response namespace: biological_process def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007631 name: feeding behavior namespace: biological_process def: "Behavior associated with the intake of food." [GOC:mah] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "behavioral response to food" EXACT [] synonym: "behavioural response to food" EXACT [] synonym: "drinking" NARROW [] synonym: "eating" NARROW [] synonym: "feeding behaviour" EXACT [] xref: Wikipedia:List_of_feeding_behaviours is_a: GO:0007610 ! behavior [Term] id: GO:0007632 name: visual behavior namespace: biological_process def: "The actions or reactions of an organism in response to a visual stimulus." [GOC:jid] synonym: "behavioral response to visual stimulus" EXACT [] synonym: "behavioural response to visual stimulus" EXACT [] synonym: "visual behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009416 ! response to light stimulus is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007633 name: pattern orientation namespace: biological_process def: "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jid, PMID:9933535] synonym: "behavioral response to pattern orientation" EXACT [] synonym: "behavioural response to pattern orientation" EXACT [] is_a: GO:0007632 ! visual behavior [Term] id: GO:0007634 name: optokinetic behavior namespace: biological_process def: "The actions or reactions of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, http://www.mercksource.com] synonym: "optokinetic behaviour" EXACT [] is_a: GO:0007632 ! visual behavior [Term] id: GO:0007635 name: chemosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] synonym: "behavioral response to chemical stimulus" EXACT [] synonym: "behavioural response to chemical stimulus" EXACT [] synonym: "chemosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0007636 name: chemosensory jump behavior namespace: biological_process def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jid] synonym: "chemosensory jump behaviour" EXACT [] synonym: "jump response to chemical stimulus" EXACT [] is_a: GO:0007630 ! jump response is_a: GO:0007635 ! chemosensory behavior [Term] id: GO:0007637 name: proboscis extension reflex namespace: biological_process def: "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid] synonym: "behavioral response to sugar stimulus, proboscis extension" EXACT [] synonym: "proboscis extension in response to sugar stimulus" EXACT [] is_a: GO:0007635 ! chemosensory behavior is_a: GO:0051780 ! behavioral response to nutrient is_a: GO:0060004 ! reflex [Term] id: GO:0007638 name: mechanosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] synonym: "behavioral response to mechanical stimulus" EXACT [] synonym: "behavioural response to mechanical stimulus" EXACT [] synonym: "mechanosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0007639 name: homeostasis of number of meristem cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem." [GOC:isa_complete] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0008001 name: fibrinogen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it does not describe an activity. is_obsolete: true replaced_by: GO:0005577 [Term] id: GO:0008002 name: lamina lucida namespace: cellular_component def: "The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194] xref: Wikipedia:Lamina_lucida is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005605 ! basal lamina [Term] id: GO:0008003 name: lamina densa namespace: cellular_component def: "The electron-dense layer of the basal lamina; lies just below the lamina lucida." [ISBN:0815316194] xref: Wikipedia:Lamina_densa is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005605 ! basal lamina [Term] id: GO:0008004 name: lamina reticularis namespace: cellular_component def: "A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194] is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005605 ! basal lamina [Term] id: GO:0008008 name: membrane attack complex protein beta2 chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005579 [Term] id: GO:0008009 name: chemokine activity namespace: molecular_function def: "The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation." [http://www.copewithcytokines.de/cope.cgi?key=Cytokines] comment: See also the molecular function term 'cytokine activity ; GO:0005125'. is_a: GO:0005125 ! cytokine activity is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0008010 name: structural constituent of chitin-based larval cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of larval cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008011 name: structural constituent of pupal chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of pupal cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008012 name: structural constituent of adult chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of adult cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008013 name: beta-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0008014 name: calcium-dependent cell adhesion molecule activity namespace: molecular_function alt_id: GO:0001538 def: "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. synonym: "cadherin" NARROW [] is_obsolete: true replaced_by: GO:0005515 replaced_by: GO:0016021 replaced_by: GO:0016339 [Term] id: GO:0008015 name: blood circulation namespace: biological_process alt_id: GO:0070261 def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825] subset: goslim_pir synonym: "hemolymph circulation" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0008016 name: regulation of heart contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cardiac contraction" EXACT [] is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0060047 ! heart contraction [Term] id: GO:0008017 name: microtubule binding namespace: molecular_function def: "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] synonym: "microtubule severing activity" RELATED [] synonym: "microtubule/chromatin interaction" RELATED [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0008018 name: structural protein of chorion (sensu Drosophila) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the function is covered by a parent term. is_obsolete: true replaced_by: GO:0005213 [Term] id: GO:0008019 name: macrophage receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its name is ambiguous, and it was never defined. is_obsolete: true consider: GO:0005044 consider: GO:0008329 [Term] id: GO:0008020 name: G-protein coupled photoreceptor activity namespace: molecular_function alt_id: GO:0004975 def: "A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light." [GOC:dph, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "G protein coupled photoreceptor activity" EXACT [] synonym: "G-protein-coupled photoreceptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0009881 ! photoreceptor activity [Term] id: GO:0008021 name: synaptic vesicle namespace: cellular_component def: "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] xref: NIF_Subcellular:sao1071221672 xref: Wikipedia:Synaptic_vesicle is_a: GO:0030136 ! clathrin-coated vesicle is_a: GO:0044456 ! synapse part [Term] id: GO:0008022 name: protein C-terminus binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "C-terminal binding" EXACT [] synonym: "C-terminal end binding" EXACT [GOC:sl] synonym: "carboxy-terminal binding" RELATED [GOC:jsg] synonym: "carboxy-terminus binding" RELATED [GOC:sl] synonym: "carboxyl-terminal binding" RELATED [GOC:jsg] synonym: "carboxyl-terminus binding" RELATED [GOC:sl] synonym: "carboxylate-terminal binding" RELATED [GOC:jsg] synonym: "carboxylate-terminus binding" NARROW [GOC:jsg] synonym: "COOH-terminal binding" NARROW [GOC:jsg] synonym: "COOH-terminus binding" NARROW [GOC:jsg, GOC:sl] is_a: GO:0005515 ! protein binding [Term] id: GO:0008023 name: transcription elongation factor complex namespace: cellular_component def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0008024 name: positive transcription elongation factor complex b namespace: cellular_component def: "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains cyclin T and a cyclin-dependent protein kinase catalytic subunit." [PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473] comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. synonym: "P-TEFb" EXACT [PMID:7759473] is_a: GO:0008023 ! transcription elongation factor complex is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex [Term] id: GO:0008025 name: diazepam binding inhibitor activity namespace: molecular_function def: "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11883709] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "DBI" EXACT [] synonym: "diazepam-binding inhibitor activity" EXACT [] is_obsolete: true consider: GO:0004857 consider: GO:0030156 consider: GO:0050796 consider: GO:0050809 consider: GO:0050810 consider: GO:0050811 consider: GO:0050812 [Term] id: GO:0008026 name: ATP-dependent helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0070035 ! purine NTP-dependent helicase activity [Term] id: GO:0008028 name: monocarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0008505 def: "Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] subset: gosubset_prok synonym: "monocarboxylate carrier" NARROW [] synonym: "prostaglandin/thromboxane transporter activity" NARROW [] xref: Reactome:14156 "monocarboxylic acid transmembrane transporter activity" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0008029 name: pentraxin receptor activity namespace: molecular_function def: "Combining with a pentraxin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). synonym: "pentaxin receptor" EXACT [] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001864 ! pentraxin binding [Term] id: GO:0008030 name: neuronal pentraxin receptor activity namespace: molecular_function def: "Combining with a neuronal pentraxin to initiate a change in cell activity." [GOC:mah, PMID:18840757] synonym: "neuronal pentaxin receptor" EXACT [] is_a: GO:0008029 ! pentraxin receptor activity [Term] id: GO:0008031 name: eclosion hormone activity namespace: molecular_function def: "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0008033 name: tRNA processing namespace: biological_process def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] subset: gosubset_prok synonym: "tRNA maturation" EXACT [GOC:vw] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0008034 name: lipoprotein binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because its text definition and implicit ontology-structure definition disagreed, and as a result the term had been used in annotations with more than one meaning. is_obsolete: true consider: GO:0071723 consider: GO:0071813 [Term] id: GO:0008035 name: high-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE." [GOC:mah] synonym: "HDL binding" EXACT [GOC:mah] is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0008036 name: diuretic hormone receptor activity namespace: molecular_function def: "Combining with a diuretic hormone to initiate a change in cell activity." [GOC:ai] is_a: GO:0004872 ! receptor activity [Term] id: GO:0008037 name: cell recognition namespace: biological_process def: "The process in which a cell in a multicellular organism interprets its surroundings." [GOC:go_curators] subset: goslim_pir synonym: "recognition of surroundings by cell" EXACT [GOC:curators] is_a: GO:0009987 ! cellular process relationship: part_of GO:0032501 ! multicellular organismal process [Term] id: GO:0008038 name: neuron recognition namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators] synonym: "neuronal cell recognition" EXACT [] is_a: GO:0008037 ! cell recognition relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0008039 name: synaptic target recognition namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] synonym: "neuronal targeting" EXACT [] is_a: GO:0008038 ! neuron recognition [Term] id: GO:0008041 name: storage protein of fat body (sensu Insecta) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular location rather than a function. is_obsolete: true replaced_by: GO:0045735 [Term] id: GO:0008042 name: iron-sulfur electron transfer carrier namespace: molecular_function def: "OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system." [GOC:kd] comment: This term was made obsolete because it refers to a class of gene products. synonym: "ferredoxin" NARROW [] synonym: "iron-sulphur electron transfer carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0008043 name: intracellular ferritin complex namespace: cellular_component def: "A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains." [GOC:jl, GOC:mah, PMID:19154717] is_a: GO:0044424 ! intracellular part is_a: GO:0070288 ! ferritin complex [Term] id: GO:0008044 name: adult behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects." [GOC:bf, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. is_obsolete: true replaced_by: GO:0030534 [Term] id: GO:0008045 name: motor axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] synonym: "motor axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance [Term] id: GO:0008046 name: axon guidance receptor activity namespace: molecular_function def: "Combining with an extracellular messenger that results in a change in cellular activity involved in axon guidance." [GOC:dph, GOC:tb] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0008047 name: enzyme activator activity namespace: molecular_function def: "Increases the activity of an enzyme." [GOC:mah] subset: gosubset_prok is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0008048 name: calcium sensitive guanylate cyclase activator activity namespace: molecular_function def: "Increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah] is_a: GO:0030250 ! guanylate cyclase activator activity [Term] id: GO:0008049 name: male courtship behavior namespace: biological_process alt_id: GO:0016542 def: "The actions or reactions of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] synonym: "male courtship behaviour" EXACT [] is_a: GO:0060179 ! male mating behavior relationship: part_of GO:0007619 ! courtship behavior [Term] id: GO:0008050 name: female courtship behavior namespace: biological_process def: "The actions or reactions of a female, for the purpose of attracting a sexual partner." [GOC:bf] synonym: "female courtship behaviour" EXACT [] is_a: GO:0060180 ! female mating behavior relationship: part_of GO:0007619 ! courtship behavior [Term] id: GO:0008051 name: farnesyl-diphosphate farnesyl transferase complex namespace: cellular_component def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah] comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer. is_obsolete: true consider: GO:0004310 [Term] id: GO:0008052 name: sensory organ boundary specification namespace: biological_process def: "The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "sense organ boundary specification" EXACT [GOC:dph] is_a: GO:0010160 ! formation of organ boundary relationship: part_of GO:0007423 ! sensory organ development [Term] id: GO:0008053 name: mitochondrial fusion namespace: biological_process def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192] is_a: GO:0006944 ! cellular membrane fusion is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048284 ! organelle fusion [Term] id: GO:0008054 name: cyclin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions." [GOC:mah, PMID:15840442] synonym: "cyclin breakdown" EXACT [] synonym: "cyclin catabolism" EXACT [] synonym: "cyclin degradation" EXACT [] synonym: "degradation of cyclin" EXACT [] is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0008055 name: ocellus pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] synonym: "ocellus pigment anabolism" EXACT [] synonym: "ocellus pigment biosynthesis" EXACT [] synonym: "ocellus pigment formation" EXACT [] synonym: "ocellus pigment synthesis" EXACT [] is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0046158 ! ocellus pigment metabolic process [Term] id: GO:0008056 name: ocellus development namespace: biological_process def: "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0008057 name: eye pigment granule organization namespace: biological_process alt_id: GO:0008059 alt_id: GO:0045318 alt_id: GO:0048751 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] synonym: "eye pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0008058 name: ocellus pigment granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm] synonym: "ocellus pigment granule organisation" EXACT [GOC:curators] synonym: "ocellus pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0008060 name: ARF GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah] synonym: "ARF GAP activity" EXACT [GOC:pg] is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005096 ! GTPase activator activity [Term] id: GO:0008061 name: chitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0008062 name: eclosion rhythm namespace: biological_process def: "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] is_a: GO:0048512 ! circadian behavior relationship: part_of GO:0007562 ! eclosion [Term] id: GO:0008063 name: Toll signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to the Toll receptor on the surface of the target cell." [GOC:go_curators, PMID:11135568, PMID:19126860] synonym: "Tl signaling pathway" EXACT [] synonym: "Tl signalling pathway" EXACT [] synonym: "Toll signalling pathway" EXACT [] xref: Reactome:1253144 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1280078 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1298959 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1326649 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1352761 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1372972 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1392988 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1417468 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1450561 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1471067 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1483083 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1496958 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1514345 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1521218 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1526806 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:1532532 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:166016 "Toll Like Receptor 4 (TLR4) Cascade" is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0008064 name: regulation of actin polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] is_a: GO:0030832 ! regulation of actin filament length relationship: regulates GO:0008154 ! actin polymerization or depolymerization [Term] id: GO:0008065 name: establishment of blood-nerve barrier namespace: biological_process def: "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh] synonym: "establishment of blood/nerve barrier" EXACT [] is_a: GO:0001885 ! endothelial cell development relationship: part_of GO:0007422 ! peripheral nervous system development [Term] id: GO:0008066 name: glutamate receptor activity namespace: molecular_function def: "Combining with glutamate to initiate a change in cell activity." [GOC:ai] subset: gosubset_prok is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0008067 name: metabotropic glutamate, GABA-B-like receptor activity namespace: molecular_function alt_id: GO:0001643 alt_id: GO:0001645 def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1285] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "class C G protein coupled receptor" BROAD [] synonym: "class C G-protein coupled receptor" BROAD [] synonym: "class C GPCR" BROAD [] synonym: "class C orphan receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0008068 name: extracellular-glutamate-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. is_a: GO:0005234 ! extracellular-glutamate-gated ion channel activity is_a: GO:0005254 ! chloride channel activity [Term] id: GO:0008069 name: dorsal/ventral axis specification, ovarian follicular epithelium namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] synonym: "dorsal-ventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] synonym: "dorsal/ventral axis determination, follicular epithelium" RELATED [] synonym: "dorsal/ventral axis determination, ovarian follicular epithelium" EXACT [GOC:dph, GOC:tb] synonym: "dorsoventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009950 ! dorsal/ventral axis specification is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0008070 name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium [Term] id: GO:0008071 name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] synonym: "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded" BROAD [] synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium [Term] id: GO:0008073 name: ornithine decarboxylase inhibitor activity namespace: molecular_function def: "The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0042979 ! ornithine decarboxylase regulator activity [Term] id: GO:0008074 name: guanylate cyclase complex, soluble namespace: cellular_component def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah] comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'. is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0008075 name: receptor guanylate cyclase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0004383 consider: GO:0004872 [Term] id: GO:0008076 name: voltage-gated potassium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] subset: gosubset_prok synonym: "voltage gated potassium channel complex" EXACT [] synonym: "voltage-dependent potassium channel complex" EXACT [] synonym: "voltage-sensitive potassium channel complex" EXACT [] xref: NIF_Subcellular:sao371494298 is_a: GO:0034705 ! potassium channel complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0008077 name: Hsp70/Hsp90 organizing protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:rb] comment: This term was made obsolete because it represents a specific gene product rather than a molecular function. synonym: "Hsp70/Hsp90 organising protein activity" EXACT [] is_obsolete: true consider: GO:0030674 [Term] id: GO:0008078 name: mesodermal cell migration namespace: biological_process def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb] synonym: "mesoderm cell migration" EXACT [] is_a: GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0007509 ! mesoderm migration involved in gastrulation [Term] id: GO:0008079 name: translation termination factor activity namespace: molecular_function def: "Functions in the termination of translation." [GOC:ma] subset: gosubset_prok is_a: GO:0008135 ! translation factor activity, nucleic acid binding [Term] id: GO:0008080 name: N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0008081 name: phosphoric diester hydrolase activity namespace: molecular_function alt_id: GO:0004434 alt_id: GO:0016792 def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] subset: gosubset_prok synonym: "endonuclease VIII activity" RELATED [] synonym: "inositol or phosphatidylinositol phosphodiesterase activity" NARROW [] synonym: "inositol/phosphatidylinositol phosphodiesterase activity" NARROW [] synonym: "phosphodiesterase" NARROW [] xref: EC:3.1.4 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0008083 name: growth factor activity namespace: molecular_function def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] is_a: GO:0005102 ! receptor binding [Term] id: GO:0008084 name: imaginal disc growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an imaginal disc growth factor receptor." [GOC:mah] synonym: "imaginal disc growth factor" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0008085 name: phototransduction, visible light, light adaptation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term name is ambiguous. is_obsolete: true consider: GO:0007602 [Term] id: GO:0008086 name: light-activated voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport] synonym: "light-activated voltage gated calcium channel activity" EXACT [] synonym: "light-activated voltage-dependent calcium channel activity" EXACT [] is_a: GO:0005245 ! voltage-gated calcium channel activity is_a: GO:0010461 ! light-activated ion channel activity [Term] id: GO:0008087 name: light-activated voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679] synonym: "light-activated voltage gated calcium channel complex" EXACT [] synonym: "light-activated voltage-dependent calcium channel complex" EXACT [] synonym: "light-activated voltage-sensitive calcium channel complex" EXACT [] is_a: GO:0005891 ! voltage-gated calcium channel complex [Term] id: GO:0008088 name: axon cargo transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194] synonym: "axonal transport" EXACT [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0010970 ! microtubule-based transport [Term] id: GO:0008089 name: anterograde axon cargo transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] synonym: "anterograde axonal transport" EXACT [] is_a: GO:0008088 ! axon cargo transport [Term] id: GO:0008090 name: retrograde axon cargo transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] synonym: "retrograde axonal transport" RELATED [] is_a: GO:0008088 ! axon cargo transport [Term] id: GO:0008091 name: spectrin namespace: cellular_component def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194] xref: NIF_Subcellular:sao536287099 xref: Wikipedia:Spectrin is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0008092 name: cytoskeletal protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: gosubset_prok is_a: GO:0005515 ! protein binding [Term] id: GO:0008093 name: cytoskeletal adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0008092 ! cytoskeletal protein binding is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0008094 name: DNA-dependent ATPase activity namespace: molecular_function alt_id: GO:0004011 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] synonym: "DNA dependent ATPase activity" EXACT [] synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008095 name: inositol-1,4,5-trisphosphate receptor activity namespace: molecular_function def: "Combining with inositol-1,4,5-trisphosphate to initiate a change in cell activity." [GOC:ai] synonym: "IP3 receptor activity" EXACT [] is_a: GO:0004872 ! receptor activity [Term] id: GO:0008096 name: juvenile hormone epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol." [GOC:mah, PMID:8396141] xref: EC:3.3.2.- is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0008097 name: 5S rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382] subset: gosubset_prok is_a: GO:0019843 ! rRNA binding [Term] id: GO:0008098 name: 5S rRNA primary transcript binding namespace: molecular_function def: "Interacting selectively and non-covalently with the unprocessed 5S ribosomal RNA transcript." [GOC:jl] is_a: GO:0008097 ! 5S rRNA binding [Term] id: GO:0008100 name: lipophorin namespace: molecular_function def: "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0008101 name: decapentaplegic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:ai] synonym: "decapentaplegic receptor signalling pathway" EXACT [] synonym: "dpp receptor signaling pathway" EXACT [] synonym: "dpp receptor signalling pathway" EXACT [] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0008103 name: oocyte microtubule cytoskeleton polarization namespace: biological_process alt_id: GO:0048129 def: "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] is_a: GO:0007017 ! microtubule-based process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007309 ! oocyte axis specification relationship: part_of GO:0016325 ! oocyte microtubule cytoskeleton organization [Term] id: GO:0008104 name: protein localization namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] subset: gosubset_prok synonym: "establishment and maintenance of protein localization" EXACT [] synonym: "protein localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0008105 name: asymmetric protein localization namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma] subset: gosubset_prok synonym: "asymmetric protein localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of asymmetric protein localization" EXACT [] is_a: GO:0008104 ! protein localization [Term] id: GO:0008106 name: alcohol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] subset: gosubset_prok synonym: "alcohol:NADP dehydrogenase activity" EXACT [] synonym: "aldehyde reductase (NADPH) activity" EXACT [EC:1.1.1.2] synonym: "aldehyde reductase (NADPH2) activity" EXACT [] synonym: "NADP-aldehyde reductase activity" EXACT [] xref: EC:1.1.1.2 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN is_a: GO:0004033 ! aldo-keto reductase (NADP) activity [Term] id: GO:0008107 name: galactoside 2-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69] subset: gosubset_prok synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT [] synonym: "alpha-(1->2)-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-L-fucose:lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] xref: EC:2.4.1.69 xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN is_a: GO:0031127 ! alpha(1,2)-fucosyltransferase activity [Term] id: GO:0008108 name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose." [EC:2.7.7.12, RHEA:13992] subset: gosubset_prok synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "hexose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.12] synonym: "hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12] synonym: "uridyltransferase activity" EXACT [EC:2.7.7.12] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12] xref: EC:2.7.7.12 xref: KEGG:R00955 xref: MetaCyc:GALACTURIDYLYLTRANS-RXN xref: Reactome:22869 "UDP-glucose:hexose-1-phosphate uridylyltransferase activity" xref: RHEA:13992 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0008109 name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150] synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150] xref: EC:2.4.1.150 xref: MetaCyc:2.4.1.150-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008110 name: L-histidine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate." [EC:2.6.1.38, RHEA:16568] synonym: "histidine aminotransferase activity" BROAD [] synonym: "histidine transaminase activity" BROAD [EC:2.6.1.38] synonym: "histidine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38] xref: EC:2.6.1.38 xref: KEGG:R01161 xref: MetaCyc:HISTTRANSAM-RXN xref: RHEA:16568 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008111 name: alpha-methylacyl-CoA racemase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4] subset: gosubset_prok synonym: "2-methylacyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.4] xref: EC:5.1.99.4 xref: MetaCyc:5.1.99.4-RXN xref: Reactome:22891 "alpha-methylacyl-CoA racemase activity" is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0008112 name: nicotinamide N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine." [EC:2.1.1.1, RHEA:23887] subset: gosubset_prok synonym: "nicotinamide methyltransferase activity" EXACT [EC:2.1.1.1] synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT [EC:2.1.1.1] xref: EC:2.1.1.1 xref: KEGG:R01269 xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN xref: RHEA:23887 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008113 name: peptide-methionine-(S)-S-oxide reductase activity namespace: molecular_function alt_id: GO:0033742 def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.11, PMID:11169920] subset: gosubset_prok synonym: "methionine S-oxide reductase (S-form oxidizing) activity" EXACT [EC:1.8.4.11] synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulfoxide (protein) reductase activity" EXACT [] synonym: "methionine sulfoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulphoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "MsrA" RELATED [EC:1.8.4.11] synonym: "peptide Met(O) reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide methionine sulfoxide reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" EXACT [EC:1.8.4.11] xref: EC:1.8.4.11 xref: MetaCyc:RXN-8668 xref: MetaCyc:RXN-8669 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0008114 name: phosphogluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43] synonym: "2-keto-6-phosphogluconate reductase activity" EXACT [EC:1.1.1.43] synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT [] synonym: "6-phosphogluconate dehydrogenase (NAD)" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43] synonym: "gluconate 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.43] synonym: "phosphogluconate dehydrogenase activity" EXACT [EC:1.1.1.43] xref: EC:1.1.1.43 xref: MetaCyc:1.1.1.43-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008115 name: sarcosine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2)." [EC:1.5.3.1, RHEA:13316] subset: gosubset_prok synonym: "sarcosine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.1] xref: EC:1.5.3.1 xref: KEGG:R00610 xref: MetaCyc:SARCOX-RXN xref: RHEA:13316 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0008116 name: prostaglandin-I synthase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)." [EC:5.3.99.4, RHEA:23583] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" EXACT [EC:5.3.99.4] synonym: "cytochrome P450 CYP8A1" NARROW [] synonym: "PGI(2) synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI(2) synthetase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostacyclin synthase activity" EXACT [EC:5.3.99.4] synonym: "prostacycline synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostagladin I2 synthetase activity" EXACT [EC:5.3.99.4] xref: EC:5.3.99.4 xref: KEGG:R02267 xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN xref: Reactome:22900 "prostaglandin-I synthase activity" xref: RHEA:23583 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0008117 name: sphinganine-1-phosphate aldolase activity namespace: molecular_function alt_id: GO:0016001 def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27] subset: gosubset_prok synonym: "dihydrosphingosine 1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate alkanal-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] xref: EC:4.1.2.27 xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN xref: Reactome:22901 "sphinganine-1-phosphate aldolase activity" is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008118 name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein." [EC:2.4.99.6] synonym: "alpha2->3 sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.6] synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "SiaT" RELATED [EC:2.4.99.6] xref: EC:2.4.99.6 xref: MetaCyc:2.4.99.6-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0008119 name: thiopurine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67] subset: gosubset_prok synonym: "6-thiopurine transmethylase activity" EXACT [EC:2.1.1.67] synonym: "mercaptopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "thiopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "TPMT" RELATED [EC:2.1.1.67] xref: EC:2.1.1.67 xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN xref: Reactome:22905 "thiopurine S-methyltransferase activity" is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008120 name: ceramide glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80] subset: gosubset_prok synonym: "ceramide:UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "ceramide:UDPGlc glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "glucosylceramide synthase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] xref: EC:2.4.1.80 xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008121 name: ubiquinol-cytochrome-c reductase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] subset: gosubset_prok synonym: "coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "coenzyme QH2-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:1.10.2.2] synonym: "CoQH2-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "cytochrome bc1 complex" RELATED [] synonym: "dihydrocoenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "mitochondrial electron transport complex III" RELATED [EC:1.10.2.2] synonym: "QH2:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport)" RELATED [EC:1.10.2.2] synonym: "ubihydroquinol:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c2 reductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone--cytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome b-c1 oxidoreductase activity" EXACT [] synonym: "ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome c reductase activity" EXACT [EC:1.10.2.2] xref: EC:1.10.2.2 xref: MetaCyc:1.10.2.2-RXN is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor [Term] id: GO:0008123 name: cholesterol 7-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.17] synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT [] synonym: "cholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.17] synonym: "cholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.17] synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.17] synonym: "cytochrome P450 CYP7A1" NARROW [] xref: EC:1.14.13.17 xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN xref: Reactome:22932 "cholesterol 7-alpha-monooxygenase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008124 name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O." [EC:4.2.1.96, RHEA:11923] subset: gosubset_prok synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96] synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT [] synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" EXACT [EC:4.2.1.96] synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4alpha-carbinolamine dehydratase activity" EXACT [EC:4.2.1.96] synonym: "tetrahydrobiopterin dehydratase activity" EXACT [EC:4.2.1.96] xref: EC:4.2.1.96 xref: KEGG:R04734 xref: MetaCyc:RXN-7908 xref: Reactome:22934 "4-alpha-hydroxytetrahydrobiopterin dehydratase activity" xref: RHEA:11923 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008125 name: pancreatic elastase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [EC:3.4.21.36] comment: This term was made obsolete because it represents a gene product. synonym: "elaszym" RELATED [EC:3.4.21.36] synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36] synonym: "serine elastase" BROAD [EC:3.4.21.36] xref: EC:3.4.21.36 xref: MetaCyc:3.4.21.36-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008126 name: acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6] subset: gosubset_prok synonym: "acetic ester hydrolase activity" EXACT [EC:3.1.1.6] synonym: "acetic-ester acetylhydrolase activity" EXACT [EC:3.1.1.6] synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6] synonym: "chloroesterase" NARROW [EC:3.1.1.6] synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6] synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6] xref: EC:3.1.1.6 xref: MetaCyc:ACETYLESTERASE-RXN xref: UM-BBD_reactionID:r0170 is_a: GO:0034338 ! short-chain carboxylesterase activity [Term] id: GO:0008127 name: quercetin 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO." [EC:1.13.11.24, RHEA:15384] synonym: "flavonol 2,4-oxygenase activity" EXACT [EC:1.13.11.24] synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.24] synonym: "quercetinase activity" EXACT [EC:1.13.11.24] xref: EC:1.13.11.24 xref: KEGG:R02156 xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN xref: RHEA:15384 xref: UM-BBD_reactionID:r0891 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0008129 name: actinidain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14] comment: This term was made obsolete because it represents a gene product. synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14] synonym: "actinidin activity" EXACT [EC:3.4.22.14] synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14] xref: EC:3.4.22.14 xref: MetaCyc:3.4.22.14-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0008130 name: neutrophil collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [EC:3.4.24.34] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34] synonym: "MMP-8" EXACT [] synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34] xref: EC:3.4.24.34 xref: MetaCyc:3.4.24.34-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008131 name: primary amine oxidase activity namespace: molecular_function alt_id: GO:0004041 alt_id: GO:0008122 def: "Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide." [EC:1.4.3.21, EC:1.4.3.22, EC:1.4.3.4, MetaCyc:RXN-9597] subset: gosubset_prok synonym: "amine oxidase (copper-containing) activity" NARROW [] synonym: "amine oxidase activity" BROAD [EC:1.4.3.21] synonym: "primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.21] xref: EC:1.4.3.21 xref: KEGG:R01853 xref: MetaCyc:RXN-9597 xref: Reactome:7141 "primary amine oxidase activity" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0008132 name: pancreatic elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.21.- is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008133 name: collagenase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.24.- is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TF binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0008135 name: translation factor activity, nucleic acid binding namespace: molecular_function def: "Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome." [GOC:ai] subset: goslim_plant subset: gosubset_prok synonym: "translation factor activity, RNA binding" EXACT [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0008137 name: NADH dehydrogenase (ubiquinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] subset: gosubset_prok synonym: "coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "complex 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "complex I (electron transport chain) activity" RELATED [EC:1.6.5.3] synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:1.6.5.3] synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:1.6.5.3] synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "electron transfer complex I activity" RELATED [EC:1.6.5.3] synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:1.6.5.3] synonym: "mitochondrial electron transport complex I activity" NARROW [EC:1.6.5.3] synonym: "NADH coenzyme Q1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-Q6 oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone-1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:1.6.5.3] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "ubiquinone reductase activity" EXACT [] xref: EC:1.6.5.3 xref: MetaCyc:NADH-DEHYDROG-A-RXN xref: MetaCyc:RXN0-5330 xref: Reactome:22973 "NADH dehydrogenase (ubiquinone) activity" is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity [Term] id: GO:0008138 name: protein tyrosine/serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] subset: gosubset_prok synonym: "dual-specificity protein phosphatase" BROAD [] xref: EC:3.1.3.- is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0008139 name: nuclear localization sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai] synonym: "NLS binding" EXACT [] synonym: "nuclear localisation sequence binding" EXACT [GOC:mah] synonym: "nuclear localization signal binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0008140 name: cAMP response element binding protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with the cAMP response element binding protein." [GOC:mah] synonym: "3',5' cAMP response element binding protein binding" EXACT [] synonym: "3',5'-cAMP response element binding protein binding" EXACT [] synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT [] synonym: "CREB binding" EXACT [] synonym: "cyclic AMP response element binding protein binding" EXACT [] is_a: GO:0003713 ! transcription coactivator activity [Term] id: GO:0008141 name: puparial glue (sensu Diptera) namespace: molecular_function def: "OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147)." [PMID:825230] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true replaced_by: GO:0005198 replaced_by: GO:0007594 [Term] id: GO:0008142 name: oxysterol binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol." [http://www.onelook.com/] is_a: GO:0032934 ! sterol binding [Term] id: GO:0008143 name: poly(A) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:krc, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "poly(A) binding" EXACT [GOC:mah] synonym: "poly(rA) binding" EXACT [GOC:mah] synonym: "poly-A binding" BROAD [GOC:mah] synonym: "polyadenylate binding" BROAD [GOC:mah] is_a: GO:0003729 ! mRNA binding is_a: GO:0070717 ! poly-purine tract binding [Term] id: GO:0008144 name: drug binding namespace: molecular_function def: "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0008145 name: phenylalkylamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phenylalkylamine or any of its derivatives." [GOC:jl] is_a: GO:0008144 ! drug binding [Term] id: GO:0008146 name: sulfotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] subset: gosubset_prok synonym: "sulphotransferase activity" EXACT [] xref: EC:2.8.2 xref: Reactome:2397 "sulfotransferase activity" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0008147 name: structural constituent of bone namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008148 name: negative transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0032785 [Term] id: GO:0008149 name: para-aminobenzoic acid (PABA) synthase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai, MetaCyc:PABASYN-CPLX] comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. is_obsolete: true consider: GO:0008696 consider: GO:0046820 [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "biological process" EXACT [] synonym: "biological process unknown" NARROW [] synonym: "physiological process" EXACT [] xref: Wikipedia:Biological_process disjoint_from: GO:0003674 ! molecular_function disjoint_from: GO:0005575 ! cellular_component [Term] id: GO:0008152 name: metabolic process namespace: biological_process def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process [Term] id: GO:0008153 name: para-aminobenzoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11377864, PMID:11960743] subset: gosubset_prok synonym: "4-aminobenzoic acid biosynthesis" EXACT [] synonym: "4-aminobenzoic acid biosynthetic process" EXACT [] synonym: "p-aminobenzoic acid biosynthesis" EXACT [] synonym: "p-aminobenzoic acid biosynthetic process" EXACT [] synonym: "PABA biosynthesis" EXACT [] synonym: "PABA biosynthetic process" EXACT [] synonym: "para-aminobenzoic acid anabolism" EXACT [] synonym: "para-aminobenzoic acid biosynthesis" EXACT [] synonym: "para-aminobenzoic acid formation" EXACT [] synonym: "para-aminobenzoic acid synthesis" EXACT [] synonym: "vitamin Bx biosynthesis" EXACT [] synonym: "vitamin Bx biosynthetic process" EXACT [] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046482 ! para-aminobenzoic acid metabolic process [Term] id: GO:0008154 name: actin polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] is_a: GO:0007015 ! actin filament organization is_a: GO:0034621 ! cellular macromolecular complex subunit organization [Term] id: GO:0008155 name: larval behavior (sensu Drosophila) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. is_obsolete: true replaced_by: GO:0030537 [Term] id: GO:0008156 name: negative regulation of DNA replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] subset: gosubset_prok synonym: "DNA replication inhibitor" RELATED [] synonym: "down regulation of DNA replication" EXACT [] synonym: "down-regulation of DNA replication" EXACT [] synonym: "downregulation of DNA replication" EXACT [] synonym: "inhibition of DNA replication" NARROW [] is_a: GO:0006275 ! regulation of DNA replication is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0006260 ! DNA replication [Term] id: GO:0008157 name: protein phosphatase 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] is_a: GO:0019903 ! protein phosphatase binding [Term] id: GO:0008158 name: hedgehog receptor activity namespace: molecular_function def: "Combining with the hedgehog protein to initiate a change in cell activity." [GOC:go_curators] synonym: "patched activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0008159 name: positive transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0032786 [Term] id: GO:0008160 name: protein tyrosine phosphatase activator activity namespace: molecular_function def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0072542 ! protein phosphatase activator activity [Term] id: GO:0008161 name: carbamate resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046681 [Term] id: GO:0008162 name: cyclodiene resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046682 [Term] id: GO:0008163 name: DDT resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046680 [Term] id: GO:0008164 name: organophosphorus resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046683 [Term] id: GO:0008165 name: pyrethroid resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046684 [Term] id: GO:0008166 name: viral replication namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms. is_obsolete: true consider: GO:0019079 [Term] id: GO:0008167 name: sigma virus replication namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] is_obsolete: true replaced_by: GO:0019079 [Term] id: GO:0008168 name: methyltransferase activity namespace: molecular_function alt_id: GO:0004480 def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methylase" BROAD [] xref: EC:2.1.1 xref: Reactome:1062 "methyltransferase activity" is_a: GO:0016741 ! transferase activity, transferring one-carbon groups [Term] id: GO:0008169 name: C-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008170 name: N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008171 name: O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008172 name: S-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- xref: Reactome:9949 "S-methyltransferase activity" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008173 name: RNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). subset: gosubset_prok xref: EC:2.1.1.- xref: Reactome:1979 "RNA methyltransferase activity" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008174 name: mRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008175 name: tRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008173 ! RNA methyltransferase activity [Term] id: GO:0008176 name: tRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33] subset: gosubset_prok synonym: "7-methylguanine transfer ribonucleate methylase activity" EXACT [EC:2.1.1.33] synonym: "N7-methylguanine methylase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "transfer ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] xref: EC:2.1.1.33 xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0008177 name: succinate dehydrogenase (ubiquinone) activity namespace: molecular_function alt_id: GO:0019737 def: "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13716] subset: gosubset_prok synonym: "complex II" RELATED [EC:1.3.5.1] synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1] synonym: "menaquinol: fumarate oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "quinol:fumarate oxidoreductase activity" EXACT [] synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1] synonym: "succinate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1] xref: EC:1.3.5.1 xref: KEGG:R02164 xref: MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN xref: Reactome:23070 "succinate dehydrogenase (ubiquinone) activity" xref: RHEA:13716 is_a: GO:0000104 ! succinate dehydrogenase activity is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0008179 name: adenylate cyclase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme adenylate cyclase." [GOC:jl] synonym: "adenylyl cyclase binding" EXACT [] xref: Reactome:23073 "adenylate cyclase binding" is_a: GO:0019899 ! enzyme binding [Term] id: GO:0008180 name: signalosome namespace: cellular_component def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] synonym: "COP9 complex" NARROW [] synonym: "CSN" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0008181 name: tumor suppressor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way. is_obsolete: true consider: GO:0051726 [Term] id: GO:0008184 name: glycogen phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN] subset: gosubset_prok xref: MetaCyc:GLYCOPHOSPHORYL-RXN xref: Reactome:23099 "glycogen phosphorylase activity" is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0008186 name: RNA-dependent ATPase activity namespace: molecular_function alt_id: GO:0004010 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008187 name: poly-pyrimidine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl] is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0008188 name: neuropeptide receptor activity namespace: molecular_function def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled is_a: GO:0030594 ! neurotransmitter receptor activity is_a: GO:0042923 ! neuropeptide binding [Term] id: GO:0008189 name: apoptosis inhibitor activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly block any step in the process of apoptosis." [GOC:hb] comment: This term was made obsolete because it represents involvement in a biological process. is_obsolete: true replaced_by: GO:0006916 [Term] id: GO:0008190 name: eukaryotic initiation factor 4E binding namespace: molecular_function def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "eIF4E binding" EXACT [] is_a: GO:0031369 ! translation initiation factor binding [Term] id: GO:0008191 name: metalloendopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai] subset: gosubset_prok synonym: "metalloprotease inhibitor" BROAD [] synonym: "metalloproteinase inhibitor" BROAD [] is_a: GO:0004866 ! endopeptidase inhibitor activity is_a: GO:0048551 ! metalloenzyme inhibitor activity [Term] id: GO:0008192 name: RNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah] xref: EC:2.7.7.- is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008193 name: tRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461] xref: EC:2.7.7.- is_a: GO:0008192 ! RNA guanylyltransferase activity [Term] id: GO:0008194 name: UDP-glycosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783] subset: gosubset_prok xref: Reactome:23123 "UDP-glycosyltransferase activity" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008195 name: phosphatidate phosphatase activity namespace: molecular_function alt_id: GO:0004606 def: "Catalysis of the reaction: a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4] synonym: "3-sn-phosphatidate phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "acid phosphatidyl phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "phosphatidate phosphohydrolase activity" EXACT [] synonym: "phosphatidic acid phosphatase activity" EXACT [EC:3.1.3.4] xref: EC:3.1.3.4 xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN xref: Reactome:23125 "phosphatidate phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008196 name: vitellogenin receptor activity namespace: molecular_function def: "Combining with vitellogenin to initiate a change in cell activity." [GOC:ai] is_a: GO:0004872 ! receptor activity [Term] id: GO:0008197 name: yolk protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0005198 consider: GO:0045735 [Term] id: GO:0008198 name: ferrous iron binding namespace: molecular_function def: "Interacting selectively and non-covalently with ferrous iron, Fe(II)." [GOC:ai] subset: gosubset_prok is_a: GO:0005506 ! iron ion binding [Term] id: GO:0008199 name: ferric iron binding namespace: molecular_function def: "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai] subset: gosubset_prok is_a: GO:0005506 ! iron ion binding [Term] id: GO:0008200 name: ion channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of an ion channel." [GOC:mah] subset: gosubset_prok is_a: GO:0016248 ! channel inhibitor activity [Term] id: GO:0008201 name: heparin binding namespace: molecular_function def: "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha1-4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "heparan sulfate binding" RELATED [] is_a: GO:0005539 ! glycosaminoglycan binding [Term] id: GO:0008202 name: steroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] subset: gosubset_prok synonym: "steroid metabolism" EXACT [] xref: Reactome:1253471 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1280409 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1299245 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1326987 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1353082 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1373271 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1393291 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1417783 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1450883 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1471274 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1483245 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1496931 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1514316 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1521184 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1526927 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1532663 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1536085 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1538056 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:1539337 "Metabolism of steroid hormones and vitamins A and D" xref: Reactome:196071 "Metabolism of steroid hormones and vitamins A and D" xref: Wikipedia:Steroid_metabolism is_a: GO:0006629 ! lipid metabolic process [Term] id: GO:0008203 name: cholesterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cholesterol metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process [Term] id: GO:0008204 name: ergosterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ergosterol metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process [Term] id: GO:0008205 name: ecdysone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ecdysone metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0008206 name: bile acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators] synonym: "bile acid metabolism" EXACT [] xref: Reactome:1232878 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:1253296 "Bile acid and bile salt metabolism" xref: Reactome:1260574 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:1280236 "Bile acid and bile salt metabolism" xref: Reactome:1285615 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:1299096 "Bile acid and bile salt metabolism" xref: Reactome:1306511 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:1326812 "Bile acid and bile salt metabolism" xref: Reactome:1334035 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:1352913 "Bile acid and bile salt metabolism" xref: Reactome:1373119 "Bile acid and bile salt metabolism" xref: Reactome:1379369 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:1393135 "Bile acid and bile salt metabolism" xref: Reactome:1399929 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:1417622 "Bile acid and bile salt metabolism" xref: Reactome:1450718 "Bile acid and bile salt metabolism" xref: Reactome:1471268 "Bile acid and bile salt metabolism" xref: Reactome:1483239 "Bile acid and bile salt metabolism" xref: Reactome:1496925 "Bile acid and bile salt metabolism" xref: Reactome:1514313 "Bile acid and bile salt metabolism" xref: Reactome:1521182 "Bile acid and bile salt metabolism" xref: Reactome:1526921 "Bile acid and bile salt metabolism" xref: Reactome:1532660 "Bile acid and bile salt metabolism" xref: Reactome:1538052 "Bile acid and bile salt metabolism" xref: Reactome:1539318 "Bile acid and bile salt metabolism" xref: Reactome:159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:194068 "Bile acid and bile salt metabolism" is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0008207 name: C21-steroid hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008208 name: C21-steroid hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone breakdown" EXACT [] synonym: "C21-steroid hormone catabolism" EXACT [] synonym: "C21-steroid hormone degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0008209 name: androgen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "androgen metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008210 name: estrogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "estrogen metabolism" EXACT [] synonym: "oestrogen metabolic process" EXACT [] synonym: "oestrogen metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008211 name: glucocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "glucocorticoid metabolism" EXACT [] synonym: "glucocorticosteroid metabolic process" EXACT [] synonym: "glucocorticosteroid metabolism" EXACT [] is_a: GO:0008207 ! C21-steroid hormone metabolic process [Term] id: GO:0008212 name: mineralocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "mineralocorticoid metabolism" EXACT [] is_a: GO:0008207 ! C21-steroid hormone metabolic process [Term] id: GO:0008213 name: protein alkylation namespace: biological_process def: "The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ma] subset: gosubset_prok synonym: "protein amino acid alkylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0008214 name: protein dealkylation namespace: biological_process def: "The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid dealkylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0008215 name: spermine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [CHEBI:15746, GOC:curators] subset: gosubset_prok synonym: "spermine metabolism" EXACT [] xref: Reactome:1232245 "Spermine is oxidized to spermidine" xref: Reactome:1259971 "Spermine is oxidized to spermidine" xref: Reactome:1285262 "Spermine is oxidized to spermidine" xref: Reactome:1305899 "Spermine is oxidized to spermidine" xref: Reactome:1333465 "Spermine is oxidized to spermidine" xref: Reactome:1357842 "Spermine is oxidized to spermidine" xref: Reactome:1378904 "Spermine is oxidized to spermidine" xref: Reactome:1399405 "Spermine is oxidized to spermidine" xref: Reactome:141341 "Spermine is oxidized to spermidine" xref: Reactome:1426346 "Spermine is oxidized to spermidine" xref: Reactome:1488946 "Spermine is oxidized to spermidine" xref: Reactome:1503729 "Spermine is oxidized to spermidine" xref: Reactome:1524232 "Spermine is oxidized to spermidine" is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0008216 name: spermidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] subset: gosubset_prok synonym: "spermidine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0008217 name: regulation of blood pressure namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure homeostasis" RELATED [] synonym: "blood pressure regulation" EXACT [] synonym: "control of blood pressure" RELATED [] xref: Wikipedia:Blood_pressure#Regulation is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0008218 name: bioluminescence namespace: biological_process def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Wikipedia:Bioluminescence is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0008219 name: cell death namespace: biological_process def: "A biological process that results in permanent cessation of all vital functions of a cell." [GOC:mah] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process is_a: GO:0016265 ! death [Term] id: GO:0008220 name: necrosis namespace: biological_process def: "OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism." [GOC:ma] comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created. is_obsolete: true consider: GO:0001906 consider: GO:0008219 consider: GO:0012501 consider: GO:0019835 consider: GO:0070265 [Term] id: GO:0008222 name: tumor antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true [Term] id: GO:0008224 name: Gram-positive antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050830 [Term] id: GO:0008225 name: Gram-negative antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050829 [Term] id: GO:0008226 name: tyramine receptor activity namespace: molecular_function def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [http://www.onelook.com/] is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0008227 name: G-protein coupled amine receptor activity namespace: molecular_function def: "A receptor that binds an extracellular amine and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers." [GOC:dph] subset: gosubset_prok synonym: "biogenic amine receptor" NARROW [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0008228 name: opsonization namespace: biological_process def: "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." [GOC:add, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"] xref: Wikipedia:Opsonin is_a: GO:0002252 ! immune effector process relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0008229 name: opsonin activity namespace: molecular_function def: "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0003823 [Term] id: GO:0008230 name: ecdysone receptor holocomplex namespace: cellular_component def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] is_a: GO:0005667 ! transcription factor complex is_a: GO:0043235 ! receptor complex [Term] id: GO:0008231 name: repressor ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333] synonym: "repressor ecdysone receptor holocomplex" RELATED [] is_a: GO:0008230 ! ecdysone receptor holocomplex [Term] id: GO:0008232 name: activator ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333] synonym: "activator ecdysone receptor holocomplex" RELATED [] is_a: GO:0008230 ! ecdysone receptor holocomplex [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" EXACT [] xref: EC:3.4 xref: Reactome:1687 "peptidase activity" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0008234 name: cysteine-type peptidase activity namespace: molecular_function alt_id: GO:0004220 def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] subset: gosubset_prok synonym: "cysteine protease activity" EXACT [] synonym: "thiol protease activity" EXACT [] xref: EC:3.4.-.- is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008235 name: metalloexopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] subset: gosubset_prok xref: Reactome:1850 "metalloexopeptidase activity" is_a: GO:0008237 ! metallopeptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008236 name: serine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] subset: gosubset_prok synonym: "serine protease activity" EXACT [] is_a: GO:0017171 ! serine hydrolase activity is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008237 name: metallopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] subset: gosubset_prok synonym: "metalloprotease activity" EXACT [GOC:mah] synonym: "metalloproteinase activity" EXACT [GOC:mah] xref: Reactome:1795 "metallopeptidase activity" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008238 name: exopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] subset: gosubset_prok synonym: "exoprotease activity" EXACT [] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008239 name: dipeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] subset: gosubset_prok is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008240 name: tripeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah] xref: EC:3.4.14.- xref: MetaCyc:3.4.14.10-RXN xref: MetaCyc:3.4.14.9-RXN is_a: GO:0008236 ! serine-type peptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008241 name: peptidyl-dipeptidase activity namespace: molecular_function def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] subset: gosubset_prok xref: EC:3.4.15 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008242 name: omega peptidase activity namespace: molecular_function def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] subset: gosubset_prok synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED [] xref: EC:3.4.19 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008243 name: plasminogen activator activity namespace: molecular_function alt_id: GO:0004296 alt_id: GO:0004297 def: "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [EC:3.4.21.68, EC:3.4.21.73] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "abbokinase activity" EXACT [EC:3.4.21.68] synonym: "cellular plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "double-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "plasminogen activator, tissue-type" RELATED [EC:3.4.21.68] synonym: "t-PA" RELATED [EC:3.4.21.68] synonym: "t-plasminogen activator activity" NARROW [] synonym: "tissue plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "tissue-type plasminogen activator activity" RELATED [EC:3.4.21.-] synonym: "tPA activity" NARROW [EC:3.4.21.-] synonym: "two-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "u-PA" RELATED [EC:3.4.21.68] synonym: "u-plasminogen activator activity" NARROW [] synonym: "uPA" RELATED [EC:3.4.21.68] synonym: "urinary esterase A" RELATED [EC:3.4.21.68] synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "urokinase activity" RELATED [EC:3.4.21.-] synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68] synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] xref: EC:3.4.21.68 xref: EC:3.4.21.73 xref: MetaCyc:3.4.21.68-RXN xref: MetaCyc:3.4.21.73-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008245 name: lysosomal membrane hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "V-ATPase" RELATED [] is_obsolete: true consider: GO:0046611 [Term] id: GO:0008246 name: electron transfer flavoprotein namespace: molecular_function def: "OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it refers to a class of gene products. synonym: "ETF" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0008247 name: 1-alkyl-2-acetylglycerophosphocholine esterase complex namespace: cellular_component def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206] comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'. subset: gosubset_prok synonym: "2-acetyl-1-alkylglycerophosphocholine esterase complex" EXACT [] synonym: "platelet-activating factor acetylhydrolase complex" EXACT [] is_a: GO:0043234 ! protein complex [Term] id: GO:0008248 name: pre-mRNA splicing factor activity namespace: molecular_function def: "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA." [GOC:jl] comment: This term was made obsolete because it describes a biological process. is_obsolete: true consider: GO:0008380 [Term] id: GO:0008250 name: oligosaccharyltransferase complex namespace: cellular_component def: "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887] synonym: "oligosaccharyl transferase complex" EXACT [] synonym: "OST complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0008251 name: tRNA-specific adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] subset: gosubset_prok synonym: "tRNA-adenosine deaminase activity" EXACT [] xref: EC:3.5.4.- is_a: GO:0004000 ! adenosine deaminase activity [Term] id: GO:0008252 name: nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31] subset: gosubset_prok synonym: "acid nucleotidase activity" EXACT [EC:3.1.3.31] synonym: "deoxyinosine-activated nucleotidase (DIAN)" EXACT [EC:3.1.3.31] synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" EXACT [EC:3.1.3.31] synonym: "NSP I" RELATED [EC:3.1.3.31] synonym: "NSP II" RELATED [EC:3.1.3.31] synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31] synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31] xref: EC:3.1.3.31 xref: MetaCyc:NUCLEOTIDASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008253 name: 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] subset: gosubset_prok synonym: "5' nucleotidase activity" EXACT [] synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5] synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5] synonym: "5'-AMPase" NARROW [EC:3.1.3.5] synonym: "5'-mononucleotidase activity" EXACT [EC:3.1.3.5] synonym: "5'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.5] synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5] synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5] synonym: "AMPase" NARROW [EC:3.1.3.5] synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5] synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5] synonym: "UMPase" NARROW [EC:3.1.3.5] synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5] xref: EC:3.1.3.5 xref: MetaCyc:5-NUCLEOTID-RXN xref: Reactome:23614 "5'-nucleotidase activity" is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008254 name: 3'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6] synonym: "3' nucleotidase activity" EXACT [] synonym: "3'-mononucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-phosphatase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6] xref: EC:3.1.3.6 xref: MetaCyc:3-NUCLEOTID-RXN is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008255 name: ecdysis-triggering hormone activity namespace: molecular_function def: "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0008256 name: protein histidine pros-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1] subset: gosubset_prok synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "HK2" RELATED [EC:2.7.13.1] synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1] xref: EC:2.7.13.1 xref: MetaCyc:2.7.13.1-RXN is_a: GO:0004673 ! protein histidine kinase activity [Term] id: GO:0008257 name: protein histidine tele-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2] synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "HK3" RELATED [EC:2.7.13.2] synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2] xref: EC:2.7.13.2 xref: MetaCyc:2.7.13.2-RXN is_a: GO:0004673 ! protein histidine kinase activity [Term] id: GO:0008258 name: head involution namespace: biological_process def: "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0008259 name: transforming growth factor beta ligand binding to type I receptor namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function. synonym: "TGF-beta ligand binding to type I receptor" EXACT [] synonym: "TGFbeta ligand binding to type I receptor" EXACT [] is_obsolete: true consider: GO:0005025 consider: GO:0005160 consider: GO:0050431 [Term] id: GO:0008260 name: 3-oxoacid CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5] subset: gosubset_prok synonym: "3-ketoacid CoA-transferase activity" EXACT [EC:2.8.3.5] synonym: "3-ketoacid coenzyme A transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxo-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid CoA dehydrogenase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetate succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" EXACT [EC:2.8.3.5] synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-ketoacid-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-oxo-acid CoA-transferase activity" EXACT [EC:2.8.3.5] xref: EC:2.8.3.5 xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN xref: Reactome:23643 "3-oxoacid CoA-transferase activity" is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008261 name: allatostatin receptor activity namespace: molecular_function def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0008262 name: importin-alpha export receptor activity namespace: molecular_function def: "Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm." [GOC:mah, GOC:vw, PMID:12486120] synonym: "importin-alpha binding" RELATED [] is_a: GO:0005049 ! nuclear export signal receptor activity is_a: GO:0008565 ! protein transporter activity [Term] id: GO:0008263 name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623] synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT [] is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity [Term] id: GO:0008265 name: Mo-molybdopterin cofactor sulfurase activity namespace: molecular_function def: "Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764] synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT [] synonym: "molybdopterin cofactor sulfurase activity" EXACT [] synonym: "molybdopterin synthase sulfurylase activity" EXACT [] xref: Reactome:23654 "Mo-molybdopterin cofactor sulfurase activity" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0008266 name: poly(U) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah] synonym: "poly(U) binding" EXACT [GOC:mah] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0008267 name: poly-glutamine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0008268 name: receptor signaling protein tyrosine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0004871 consider: GO:0035556 [Term] id: GO:0008269 name: JAK pathway signal transduction adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0030674 ! protein binding, bridging is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0008270 name: zinc ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] subset: gosubset_prok synonym: "zinc binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0008271 name: secondary active sulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] subset: gosubset_prok synonym: "secondary active sulphate transmembrane transporter activity" EXACT [] synonym: "sulfate porter activity" RELATED [] synonym: "sulphate porter activity" EXACT [] is_a: GO:0015116 ! sulfate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008272 name: sulfate transport namespace: biological_process alt_id: GO:0006870 def: "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok synonym: "sulphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0008273 name: calcium, potassium:sodium antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] synonym: "potassium-dependent sodium/calcium exchanger" RELATED [] xref: Reactome:23689 "calcium, potassium:sodium antiporter activity" is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015368 ! calcium:cation antiporter activity is_a: GO:0022821 ! potassium ion antiporter activity [Term] id: GO:0008274 name: gamma-tubulin ring complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075] synonym: "gammaTuRC" EXACT [] is_a: GO:0000931 ! gamma-tubulin large complex [Term] id: GO:0008275 name: gamma-tubulin small complex namespace: cellular_component def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075] synonym: "gammaTuSC" EXACT [] is_a: GO:0000930 ! gamma-tubulin complex [Term] id: GO:0008276 name: protein methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008277 name: regulation of G-protein coupled receptor protein signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators] synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of GPCR protein signaling pathway" EXACT [] synonym: "regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0008278 name: cohesin complex namespace: cellular_component alt_id: GO:0008279 alt_id: GO:0043222 def: "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:sp, PMID:9887095] subset: goslim_pir synonym: "14S cohesin" NARROW [] synonym: "SMC complex" RELATED [] synonym: "SMC/kleisin ring complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0008280 name: cohesin core heterodimer namespace: cellular_component def: "The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes." [GOC:jl] synonym: "9S cohesin" NARROW [] synonym: "Smc1-Smc3 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0008278 ! cohesin complex [Term] id: GO:0008281 name: sulfonylurea receptor activity namespace: molecular_function def: "Combining with sulfonylurea to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'. synonym: "sulphonylurea receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0008282 name: ATP-sensitive potassium channel complex namespace: cellular_component def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.2 subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SUR1 subunit stimulates channel activity." [PMID:16308567, PMID:16956886] is_a: GO:0034702 ! ion channel complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0008283 name: cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. subset: goslim_generic subset: goslim_pir subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0008284 name: positive regulation of cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] subset: gosubset_prok synonym: "activation of cell proliferation" NARROW [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0008283 ! cell proliferation [Term] id: GO:0008285 name: negative regulation of cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0008283 ! cell proliferation [Term] id: GO:0008286 name: insulin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] synonym: "daf-2 receptor signaling pathway" NARROW [] synonym: "insulin receptor signalling pathway" EXACT [] xref: Reactome:1253028 "Signaling by Insulin receptor" xref: Reactome:1279958 "Signaling by Insulin receptor" xref: Reactome:1298850 "Signaling by Insulin receptor" xref: Reactome:1326533 "Signaling by Insulin receptor" xref: Reactome:1352643 "Signaling by Insulin receptor" xref: Reactome:1372859 "Signaling by Insulin receptor" xref: Reactome:1392881 "Signaling by Insulin receptor" xref: Reactome:1417348 "Signaling by Insulin receptor" xref: Reactome:1450451 "Signaling by Insulin receptor" xref: Reactome:1470977 "Signaling by Insulin receptor" xref: Reactome:1483011 "Signaling by Insulin receptor" xref: Reactome:1496775 "Signaling by Insulin receptor" xref: Reactome:1514165 "Signaling by Insulin receptor" xref: Reactome:1520999 "Signaling by Insulin receptor" xref: Reactome:1526743 "Signaling by Insulin receptor" xref: Reactome:1532467 "Signaling by Insulin receptor" xref: Reactome:1536006 "Signaling by Insulin receptor" xref: Reactome:74752 "Signaling by Insulin receptor" is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway is_a: GO:0032869 ! cellular response to insulin stimulus [Term] id: GO:0008287 name: protein serine/threonine phosphatase complex namespace: cellular_component def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0008288 name: boss receptor activity namespace: molecular_function def: "Combining with the protein bride of sevenless (boss) to initiate a change in cell activity." [GOC:jl] synonym: "sevenless receptor activity" RELATED [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid." [GOC:ai] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0008290 name: F-actin capping protein complex namespace: cellular_component def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0008291 name: acetylcholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] synonym: "acetylcholine metabolism" EXACT [] is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0042439 ! ethanolamine-containing compound metabolic process [Term] id: GO:0008292 name: acetylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine anabolism" EXACT [] synonym: "acetylcholine biosynthesis" EXACT [] synonym: "acetylcholine formation" EXACT [] synonym: "acetylcholine synthesis" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0008293 name: torso signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the torso transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:go_curators] synonym: "torso signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0008294 name: calcium- and calmodulin-responsive adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah] synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT [] synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT [] xref: Reactome:23748 "calcium- and calmodulin-responsive adenylate cyclase activity" is_a: GO:0004016 ! adenylate cyclase activity [Term] id: GO:0008295 name: spermidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "spermidine anabolism" EXACT [] synonym: "spermidine biosynthesis" EXACT [] synonym: "spermidine formation" EXACT [] synonym: "spermidine synthesis" EXACT [] xref: MetaCyc:BSUBPOLYAMSYN-PWY xref: MetaCyc:POLYAMINSYN3-PWY is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0008216 ! spermidine metabolic process [Term] id: GO:0008296 name: 3'-5'-exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah] synonym: "3'-5' exodeoxyribonuclease activity" EXACT [] xref: Reactome:23750 "3'-5'-exodeoxyribonuclease activity" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008297 name: single-stranded DNA specific exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah] subset: gosubset_prok synonym: "ssDNA-specific exodeoxyribonuclease activity" EXACT [GOC:mah] is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008298 name: intracellular mRNA localization namespace: biological_process def: "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of intracellular RNA localization" EXACT [] synonym: "intracellular mRNA localisation" EXACT [GOC:mah] synonym: "intracellular mRNA positioning" NARROW [] synonym: "mRNA localization, intracellular" EXACT [] synonym: "mRNA positioning, intracellular" NARROW [] is_a: GO:0006403 ! RNA localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0008299 name: isoprenoid biosynthetic process namespace: biological_process alt_id: GO:0009241 def: "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "isoprenoid anabolism" EXACT [] synonym: "isoprenoid biosynthesis" EXACT [] synonym: "isoprenoid formation" EXACT [] synonym: "isoprenoid synthesis" EXACT [] synonym: "polyisoprenoid anabolism" NARROW [] synonym: "polyisoprenoid biosynthesis" NARROW [] synonym: "polyisoprenoid biosynthetic process" NARROW [] synonym: "polyisoprenoid formation" NARROW [] synonym: "polyisoprenoid synthesis" NARROW [] synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] xref: MetaCyc:POLYISOPRENSYN-PWY is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0008300 name: isoprenoid catabolic process namespace: biological_process alt_id: GO:0016097 def: "The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "isoprenoid breakdown" EXACT [] synonym: "isoprenoid catabolism" EXACT [] synonym: "isoprenoid degradation" EXACT [] synonym: "polyisoprenoid breakdown" NARROW [] synonym: "polyisoprenoid catabolic process" NARROW [] synonym: "polyisoprenoid catabolism" NARROW [] synonym: "polyisoprenoid degradation" NARROW [] synonym: "polyterpene catabolic process" NARROW [] synonym: "polyterpene catabolism" NARROW [] is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0008301 name: DNA bending activity namespace: molecular_function def: "An activity that results in binding to DNA and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, PMID:10710711, PMID:19037758] subset: gosubset_prok is_a: GO:0003677 ! DNA binding [Term] id: GO:0008302 name: female germline ring canal formation, actin assembly namespace: biological_process def: "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238] synonym: "nurse cell ring canal formation, actin assembly" NARROW [] synonym: "ovarian ring canal formation, actin assembly" NARROW [] synonym: "ring canal formation, actin assembly" BROAD [] is_a: GO:0007015 ! actin filament organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007301 ! female germline ring canal formation [Term] id: GO:0008303 name: caspase complex namespace: cellular_component def: "A protein complex that is located in the cytosol and acts as a cysteine-type endopeptidase are involved in apoptosis; the peptidase activity has specificity for the hydrolysis of aspartyl bonds." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0008304 name: eukaryotic translation initiation factor 4 complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "eIF-4" EXACT [] is_obsolete: true replaced_by: GO:0016281 [Term] id: GO:0008305 name: integrin complex namespace: cellular_component def: "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136] subset: gosubset_prok synonym: "laminin receptor protein" RELATED [] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0008306 name: associative learning namespace: biological_process def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] synonym: "classical conditioning" EXACT [] synonym: "conditional learning" EXACT [] synonym: "conditional response" EXACT [] synonym: "Pavlovian conditioning" EXACT [] xref: Wikipedia:Learning#Associative_learning is_a: GO:0007612 ! learning [Term] id: GO:0008307 name: structural constituent of muscle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008308 name: voltage-gated anion channel activity namespace: molecular_function alt_id: GO:0022844 def: "Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage-dependent ion-selective channel activity" RELATED [] synonym: "voltage-gated ion-selective channel activity" RELATED [] is_a: GO:0005244 ! voltage-gated ion channel activity is_a: GO:0005253 ! anion channel activity [Term] id: GO:0008309 name: double-stranded DNA specific exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah] is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008310 name: single-stranded DNA specific 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah] synonym: "ssDNA-specific 3'-5' exodeoxyribonuclease activity" EXACT [GOC:mah] is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity is_a: GO:0008297 ! single-stranded DNA specific exodeoxyribonuclease activity [Term] id: GO:0008311 name: double-stranded DNA specific 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah] is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity is_a: GO:0008309 ! double-stranded DNA specific exodeoxyribonuclease activity [Term] id: GO:0008312 name: 7S RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0008313 name: gurken receptor activity namespace: molecular_function def: "Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf] is_a: GO:0005006 ! epidermal growth factor receptor activity [Term] id: GO:0008314 name: gurken receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf] synonym: "gurken receptor signalling pathway" EXACT [] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0008315 name: meiotic G2/MI transition namespace: biological_process def: "The cell cycle process in which a cell progresses from meiotic prophase to metaphase I." [PMID:15088480] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0008316 name: structural constituent of vitelline membrane namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] is_a: GO:0035804 ! structural constituent of egg coat [Term] id: GO:0008317 name: gurken receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the gurken growth factor receptor." [GOC:ai] synonym: "gurken receptor ligand" NARROW [] is_a: GO:0005154 ! epidermal growth factor receptor binding [Term] id: GO:0008318 name: protein prenyltransferase activity namespace: molecular_function alt_id: GO:0008244 def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah] xref: EC:2.5.1.- is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0008319 name: prenyl protein specific endopeptidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.24.- is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008320 name: protein transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a protein from one side of a membrane to the other." [GOC:jl] subset: gosubset_prok is_a: GO:0008565 ! protein transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity [Term] id: GO:0008321 name: Ral guanyl-nucleotide exchange factor activity namespace: molecular_function alt_id: GO:0016220 def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "Ral GDP-dissociation stimulator activity" EXACT [] xref: Reactome:24053 "Ral guanyl-nucleotide exchange factor activity" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0008322 name: Pro-X carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030536 [Term] id: GO:0008324 name: cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "transmembrane cation transporter activity" EXACT [] is_a: GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0008327 name: methyl-CpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232] is_a: GO:0000166 ! nucleotide binding is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0008328 name: ionotropic glutamate receptor complex namespace: cellular_component def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0008329 name: pattern recognition receptor activity namespace: molecular_function def: "Combining with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. Such molecular patterns are sometimes associated with potential pathogens." [PMID:12507420, PMID:12925128, PMID:14523544] comment: Note that this term and its child terms are intended for gene products which are directly coupled to a signal transduction pathway; gene products which recognize polymeric structures such as polysaccharides or peptidoglycans in extracellular space, but are not directly coupled to signal transduction pathway, should use the term 'pattern binding ; GO:0001871' or its child terms. Note that many gene products that are called pattern recognition receptors in the literature have a broad range of potential ligands and also can be annotated to 'scavenger receptor activity ; GO:0005044'. synonym: "macrophage receptor activity" RELATED [] is_a: GO:0004872 ! receptor activity [Term] id: GO:0008330 name: protein tyrosine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] xref: EC:3.1.3.- is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0008331 name: high voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "high voltage gated calcium channel activity" EXACT [] synonym: "high voltage-dependent calcium channel activity" EXACT [] is_a: GO:0005245 ! voltage-gated calcium channel activity [Term] id: GO:0008332 name: low voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "low voltage gated calcium channel activity" EXACT [] synonym: "low voltage-dependent calcium channel activity" EXACT [] synonym: "T-type channel" EXACT [] is_a: GO:0005245 ! voltage-gated calcium channel activity [Term] id: GO:0008333 name: endosome to lysosome transport namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] is_a: GO:0007041 ! lysosomal transport is_a: GO:0016197 ! endosome transport [Term] id: GO:0008334 name: histone mRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:mah] synonym: "histone mRNA metabolism" EXACT [] xref: Reactome:111367 "SLBP independent Processing of Histone Pre-mRNAs" xref: Reactome:111438 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA" xref: Reactome:1230155 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA" xref: Reactome:1253100 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" xref: Reactome:1257948 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA" xref: Reactome:1257963 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA" xref: Reactome:1258792 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA" xref: Reactome:1280035 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" xref: Reactome:1280120 "SLBP independent Processing of Histone Pre-mRNAs" xref: Reactome:1283527 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA" xref: Reactome:1283551 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA" xref: Reactome:1284247 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA" xref: Reactome:1298920 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" xref: Reactome:1299002 "SLBP independent Processing of Histone Pre-mRNAs" xref: Reactome:1303986 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA" xref: Reactome:1304001 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA" xref: Reactome:1304730 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA" xref: Reactome:1326605 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" xref: Reactome:1326692 "SLBP independent Processing of Histone Pre-mRNAs" xref: Reactome:1331449 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA" xref: Reactome:1331464 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA" xref: Reactome:1332366 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA" xref: Reactome:1352716 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" xref: Reactome:1352804 "SLBP independent Processing of Histone Pre-mRNAs" xref: Reactome:1356336 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA" xref: Reactome:1356349 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA" xref: Reactome:1356940 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA" xref: Reactome:1372932 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" xref: Reactome:1373013 "SLBP independent Processing of Histone Pre-mRNAs" xref: Reactome:1377335 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA" xref: Reactome:1392948 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" xref: Reactome:1397619 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA" xref: Reactome:1397635 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA" xref: Reactome:1398304 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA" xref: Reactome:1417425 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" xref: Reactome:1417505 "SLBP independent Processing of Histone Pre-mRNAs" xref: Reactome:77584 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA" xref: Reactome:77585 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA" xref: Reactome:77588 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0008335 name: female germline ring canal stabilization namespace: biological_process def: "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators] synonym: "nurse cell ring canal stabilization" NARROW [] synonym: "ovarian ring canal stabilization" NARROW [] is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0008336 name: gamma-butyrobetaine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate." [EC:1.14.11.1, RHEA:24031] subset: gosubset_prok synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.1] synonym: "alpha-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "g-butyrobetaine dioxygenase activity" EXACT [] synonym: "gamma-BBH activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT [] xref: EC:1.14.11.1 xref: KEGG:R02397 xref: MetaCyc:1.14.11.1-RXN xref: Reactome:24086 "gamma-butyrobetaine dioxygenase activity" xref: RHEA:24031 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0008337 name: selectin namespace: molecular_function def: "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins." [ISBN:0124325653] comment: This term was made obsolete because it describes a class of gene products. is_obsolete: true consider: GO:0005102 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 [Term] id: GO:0008340 name: determination of adult lifespan namespace: biological_process def: "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0010259 ! multicellular organismal aging [Term] id: GO:0008341 name: response to cocaine (sensu Insecta) namespace: biological_process def: "OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. is_obsolete: true consider: GO:0048148 [Term] id: GO:0008342 name: larval feeding behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Feeding behavior in an insect larva." [GOC:jid, GOC:mah] comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. is_obsolete: true replaced_by: GO:0030536 [Term] id: GO:0008343 name: adult feeding behavior namespace: biological_process def: "Feeding behavior in a fully developed and mature organism." [GOC:mah] comment: See also the biological process term 'feeding behavior ; GO:0007631'. synonym: "adult feeding behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0030534 ! adult behavior [Term] id: GO:0008344 name: adult locomotory behavior namespace: biological_process def: "Locomotory behavior in a fully developed and mature organism." [GOC:ai] comment: See also the biological process term 'locomotory behavior ; GO:0007626'. synonym: "adult locomotory behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0030534 ! adult behavior [Term] id: GO:0008345 name: larval locomotory behavior namespace: biological_process def: "Locomotory behavior in a larval (immature) organism." [GOC:ai] comment: See also the biological process term 'locomotory behavior ; GO:0007626'. synonym: "larval locomotory behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0030537 ! larval behavior [Term] id: GO:0008346 name: larval walking behavior namespace: biological_process def: "The actions or reactions of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:go_curators] synonym: "larval walking behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior [Term] id: GO:0008347 name: glial cell migration namespace: biological_process alt_id: GO:0043359 def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] synonym: "glia cell migration" EXACT [] is_a: GO:0016477 ! cell migration relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0008348 name: negative regulation of antimicrobial humoral response namespace: biological_process alt_id: GO:0042154 alt_id: GO:0042155 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators] synonym: "attenuation of antimicrobial humoral response" EXACT [] synonym: "down regulation of antimicrobial humoral response" EXACT [] synonym: "down-regulation of antimicrobial humoral response" EXACT [] synonym: "downregulation of antimicrobial humoral response" EXACT [] synonym: "inhibition of antimicrobial humoral response" NARROW [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0043901 ! negative regulation of multi-organism process relationship: negatively_regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0008349 name: MAP kinase kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549] synonym: "MAPKKKK" EXACT [] xref: EC:2.7.11.- is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity [Term] id: GO:0008350 name: kinetochore motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes cellular component information. is_obsolete: true consider: GO:0000776 consider: GO:0003777 [Term] id: GO:0008351 name: microtubule severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0008017 replaced_by: GO:0051013 [Term] id: GO:0008352 name: katanin complex namespace: cellular_component def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766] comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'. is_a: GO:0005875 ! microtubule associated complex is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0008353 name: RNA polymerase II carboxy-terminal domain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] synonym: "[RNA-polymerase]-subunit kinase activity" BROAD [] synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" BROAD [EC:2.7.11.23] synonym: "CTD kinase activity" EXACT [EC:2.7.11.23] synonym: "RNA polymerase subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "RNA-polymerase-subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "STK9" RELATED [EC:2.7.11.23] xref: EC:2.7.11.23 xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0008354 name: germ cell migration namespace: biological_process def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] synonym: "germ-cell migration" EXACT [] synonym: "primordial germ cell migration" RELATED [] is_a: GO:0016477 ! cell migration is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0008355 name: olfactory learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] is_a: GO:0008306 ! associative learning is_a: GO:0042048 ! olfactory behavior [Term] id: GO:0008356 name: asymmetric cell division namespace: biological_process def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] synonym: "asymmetric cytokinesis" RELATED [] synonym: "asymmetrical cell division" EXACT [] synonym: "asymmetrical cytokinesis" RELATED [] xref: Wikipedia:Asymmetric_cell_division is_a: GO:0051301 ! cell division [Term] id: GO:0008358 name: maternal determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0008595 ! anterior/posterior axis specification, embryo [Term] id: GO:0008359 name: regulation of bicoid mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb] synonym: "regulation of bicoid mRNA localisation" EXACT [GOC:mah] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0045450 ! bicoid mRNA localization [Term] id: GO:0008360 name: regulation of cell shape namespace: biological_process alt_id: GO:0045788 alt_id: GO:0045789 def: "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0008361 name: regulation of cell size namespace: biological_process def: "Any process that modulates the size of a cell." [GOC:go_curators] subset: gosubset_prok synonym: "cell size control" EXACT [] is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0008362 name: chitin-based embryonic cuticle biosynthetic process namespace: biological_process def: "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] synonym: "embryonic cuticle anabolism" BROAD [] synonym: "embryonic cuticle biosynthetic process" BROAD [] synonym: "embryonic cuticle formation" BROAD [] synonym: "embryonic cuticle synthesis" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development [Term] id: GO:0008363 name: larval chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "larval cuticle anabolism" BROAD [] synonym: "larval cuticle biosynthetic process" BROAD [] synonym: "larval cuticle formation" BROAD [] synonym: "larval cuticle synthesis" BROAD [] is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0008364 name: pupal chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "pupal cuticle anabolism" BROAD [] synonym: "pupal cuticle formation" BROAD [] synonym: "pupal cuticle synthesis" BROAD [] is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle relationship: part_of GO:0035209 ! pupal development [Term] id: GO:0008365 name: adult chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "adult chitin-based cuticle anabolism" EXACT [] synonym: "adult chitin-based cuticle biosynthetic process" EXACT [] synonym: "adult chitin-based cuticle formation" EXACT [] synonym: "adult chitin-based cuticle synthesis" EXACT [] synonym: "adult cuticle anabolism" BROAD [] synonym: "adult cuticle biosynthetic process" BROAD [] synonym: "adult cuticle formation" BROAD [] synonym: "adult cuticle synthesis" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development [Term] id: GO:0008366 name: axon ensheathment namespace: biological_process alt_id: GO:0042553 def: "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437] synonym: "cellular axon ensheathment" EXACT [] synonym: "cellular nerve ensheathment" RELATED [] synonym: "nerve ensheathment" RELATED [] is_a: GO:0007272 ! ensheathment of neurons [Term] id: GO:0008369 name: obsolete molecular function namespace: molecular_function def: "OBSOLETE. These are terms that have been removed from the active function ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008370 name: obsolete cellular component namespace: cellular_component def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008371 name: obsolete biological process namespace: biological_process def: "OBSOLETE. These are terms that have been removed from the active process ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008373 name: sialyltransferase activity namespace: molecular_function def: "Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: EC:2.4.99.- xref: MetaCyc:2.4.99.10-RXN is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008374 name: O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: Reactome:1150 "O-acyltransferase activity" is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0008375 name: acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GlcNAc transferase activity" EXACT [] xref: EC:2.4.1.- xref: MetaCyc:2.4.1.223-RXN xref: Reactome:1550 "acetylglucosaminyltransferase activity" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008376 name: acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "GalNAc transferase activity" EXACT [] xref: EC:2.4.1.- is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008377 name: light-induced release of internally sequestered calcium ion namespace: biological_process def: "The process in which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai] synonym: "light-induced release of calcium from internal store" EXACT [] synonym: "light-induced release of internally sequestered calcium ion (Ca2+)" EXACT [] synonym: "light-induced release of internally stored calcium ion (Ca2+)" EXACT [] is_a: GO:0051283 ! negative regulation of sequestering of calcium ion relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction [Term] id: GO:0008378 name: galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.4.1.- xref: MetaCyc:2.4.1.151-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008379 name: thioredoxin peroxidase activity namespace: molecular_function alt_id: GO:0009031 def: "Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267] subset: gosubset_prok synonym: "thiol peroxidase activity" EXACT [] synonym: "TPx activity" EXACT [] synonym: "TrxPx activity" EXACT [] xref: EC:1.11.1.- xref: MetaCyc:RXN0-267 is_a: GO:0004601 ! peroxidase activity is_a: GO:0051920 ! peroxiredoxin activity [Term] id: GO:0008380 name: RNA splicing namespace: biological_process alt_id: GO:0006395 def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] subset: gosubset_prok synonym: "pre-mRNA splicing factor activity" RELATED [] xref: Reactome:1252972 "mRNA Splicing" xref: Reactome:1279902 "mRNA Splicing" xref: Reactome:1326475 "mRNA Splicing" xref: Reactome:1352589 "mRNA Splicing" xref: Reactome:1372814 "mRNA Splicing" xref: Reactome:1417302 "mRNA Splicing" xref: Reactome:1450392 "mRNA Splicing" xref: Reactome:1470919 "mRNA Splicing" xref: Reactome:1482956 "mRNA Splicing" xref: Reactome:1496782 "mRNA Splicing" xref: Reactome:1514172 "mRNA Splicing" xref: Reactome:1521007 "mRNA Splicing" xref: Reactome:1532472 "mRNA Splicing" xref: Reactome:1536012 "mRNA Splicing" xref: Reactome:72172 "mRNA Splicing" xref: Wikipedia:RNA_splicing is_a: GO:0006396 ! RNA processing [Term] id: GO:0008381 name: mechanically-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005216 ! ion channel activity is_a: GO:0022833 ! mechanically gated channel activity [Term] id: GO:0008384 name: IkappaB kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10] comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. The kinase is composed of alpha, beta and gamma subunits, of which the latter does not have kinase activity but is presumed to play a regulatory role. synonym: "ATP:IkappaB protein phosphotransferase activity" EXACT [EC:2.7.11.10] synonym: "CHUK" RELATED [EC:2.7.11.10] synonym: "ikappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "IKBKA" RELATED [EC:2.7.11.10] synonym: "IKBKB" RELATED [EC:2.7.11.10] synonym: "IKK" RELATED [EC:2.7.11.10] synonym: "IKK-1" RELATED [EC:2.7.11.10] synonym: "IKK-2" RELATED [EC:2.7.11.10] synonym: "inhibitor of NF-kappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "inhibitor of NFkappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "STK12" RELATED [EC:2.7.11.10] synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10] synonym: "TBK1" RELATED [EC:2.7.11.10] xref: EC:2.7.11.10 xref: MetaCyc:2.7.11.10-RXN xref: Reactome:24217 "IkappaB kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0008385 name: IkappaB kinase complex namespace: cellular_component def: "A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role." [GOC:ma] synonym: "IKK complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0008386 name: cholesterol monooxygenase (side-chain-cleaving) activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6] synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6] synonym: "cholesterol 20-22-desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C(20-22) desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C20-22 desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" EXACT [EC:1.14.15.6] synonym: "Cyp11a1" NARROW [] synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6] synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6] synonym: "desmolase, steroid 20-22" EXACT [EC:1.14.15.6] synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6] synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6] synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6] xref: EC:1.14.15.6 xref: MetaCyc:1.14.15.6-RXN xref: Reactome:24219 "cholesterol monooxygenase (side-chain-cleaving) activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008387 name: steroid 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP2A12" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008388 name: testosterone 15-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2A4" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008389 name: coumarin 7-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [Reactome:163103] synonym: "cytochrome P450 CYP2A5" NARROW [] xref: Reactome:24222 "coumarin 7-hydroxylase activity" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008390 name: testosterone 16-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2B10" NARROW [] synonym: "cytochrome P450 CYP2B9" NARROW [] synonym: "cytochrome P450 CYP2D10" NARROW [] synonym: "cytochrome P450 CYP2D11" NARROW [] synonym: "cytochrome P450 CYP2D9" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008391 name: arachidonic acid monooxygenase activity namespace: molecular_function def: "Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water." [GOC:mah] synonym: "cytochrome P450 CYP2B19" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008392 name: arachidonic acid epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2J5" NARROW [] synonym: "cytochrome P450 CYP2J6" NARROW [] xref: Reactome:24235 "arachidonic acid epoxygenase activity" is_a: GO:0008391 ! arachidonic acid monooxygenase activity [Term] id: GO:0008395 name: steroid hydroxylase activity namespace: molecular_function alt_id: GO:0008394 def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "cytochrome P450 CYP2G1" NARROW [] synonym: "olfactory-specific steroid hydroxylase activity" NARROW [] xref: Reactome:12240 "steroid hydroxylase activity" is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0008396 name: oxysterol 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791] synonym: "cytochrome P450 CYP7B1" NARROW [] xref: Reactome:24238 "oxysterol 7-alpha-hydroxylase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008397 name: sterol 12-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP8B1" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008398 name: sterol 14-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [EC:1.14.13.70] subset: gosubset_prok synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.13.70] synonym: "cytochrome P450 CYP51" NARROW [] synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70] xref: EC:1.14.13.70 xref: MetaCyc:1.14.13.70-RXN xref: Reactome:24240 "sterol 14-demethylase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen is_a: GO:0032451 ! demethylase activity [Term] id: GO:0008399 name: naphthalene hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide." [PMID:1742282, PMID:1981702] synonym: "cytochrome P450 CYP2F2" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008401 name: retinoic acid 4-hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid." [PMID:19519282] synonym: "cytochrome P450 CYP261" NARROW [] xref: Reactome:24496 "retinoic acid 4-hydroxylase activity" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008403 name: 25-hydroxycholecalciferol-24-hydroxylase activity namespace: molecular_function alt_id: GO:0030344 def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol." [ISBN:0471331309 "Biochemical Pathways"] synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT [] synonym: "cytochrome P450 CYP24" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0070576 ! vitamin D 24-hydroxylase activity [Term] id: GO:0008404 name: arachidonic acid 14,15-epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2C29" NARROW [] synonym: "cytochrome P450 CYP2C39" NARROW [] is_a: GO:0008392 ! arachidonic acid epoxygenase activity [Term] id: GO:0008405 name: arachidonic acid 11,12-epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2C38" NARROW [] is_a: GO:0008392 ! arachidonic acid epoxygenase activity [Term] id: GO:0008406 name: gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048513 ! organ development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0045137 ! development of primary sexual characteristics [Term] id: GO:0008407 name: bristle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the bristle are generated and organized." [GOC:go_curators] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0022416 ! bristle development [Term] id: GO:0008408 name: 3'-5' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] subset: gosubset_prok synonym: "3'-5'-exonuclease activity" EXACT [] is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0008409 name: 5'-3' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai] subset: gosubset_prok is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0008410 name: CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.8.3.- is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0008411 name: 4-hydroxybutyrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl] subset: gosubset_prok is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008412 name: 4-hydroxybenzoate octaprenyltransferase activity namespace: molecular_function alt_id: GO:0000043 alt_id: GO:0048043 alt_id: GO:0048044 def: "Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN] subset: gosubset_prok synonym: "4-HB polyprenyltransferase activity" EXACT [] synonym: "para-hydroxybenzoate transferase activity" EXACT [] synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT [] synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT [] synonym: "PHB polyprenyl diphosphate transferase activity" EXACT [] xref: EC:2.5.1.- xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0008413 name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription." [PMID:15878881] subset: gosubset_prok synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT [] synonym: "8-oxo-7,8-dihydroguanine triphosphatase activity" EXACT [] synonym: "8-oxo-7,8-dihydroguanosine triphosphatase activity" EXACT [] synonym: "8-oxo-GTPase activity" EXACT [] xref: EC:3.6.1.- is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0008414 name: CDP-alcohol phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0008415 name: acyltransferase activity namespace: molecular_function def: "Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier." [EC:2.3.1.-, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.3.1.- xref: Reactome:1091 "acyltransferase activity" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008416 name: delta5-delta2,4-dienoyl-CoA isomerase activity namespace: molecular_function def: "Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA." [PMID:11278886] xref: EC:5.3.3.- is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0008417 name: fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok xref: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008418 name: protein N-terminal asparagine amidohydrolase activity namespace: molecular_function def: "Catalysis of the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481] xref: EC:3.5.1.- is_a: GO:0004067 ! asparaginase activity [Term] id: GO:0008419 name: RNA lariat debranching enzyme activity namespace: molecular_function def: "Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [PMID:7519612] is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008420 name: CTD phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [EC:3.1.3.16] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0008421 name: long-chain fatty-acyl-glutamate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55] synonym: "long-chain acylglutamate amidase activity" EXACT [EC:3.5.1.55] synonym: "long-chain aminoacylase activity" EXACT [EC:3.5.1.55] synonym: "long-chain fatty acyl-glutamate deacylase activity" EXACT [GOC:mah] synonym: "long-chain-fatty-acyl-glutamate deacylase activity" EXACT [] synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55] xref: EC:3.5.1.55 xref: MetaCyc:3.5.1.55-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008422 name: beta-glucosidase activity namespace: molecular_function alt_id: GO:0016983 def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21] subset: gosubset_prok synonym: "amygdalase activity" NARROW [EC:3.2.1.21] synonym: "amygdalinase" BROAD [EC:3.2.1.21] synonym: "arbutinase activity" EXACT [EC:3.2.1.21] synonym: "aryl-beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-1,6-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "beta-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "cellobiase activity" NARROW [EC:3.2.1.21] synonym: "cytokine beta-glucosidase activity" NARROW [] synonym: "elaterase activity" NARROW [EC:3.2.1.21] synonym: "emulsin" RELATED [EC:3.2.1.21] synonym: "gentiobiase activity" NARROW [EC:3.2.1.21] synonym: "gentobiase activity" NARROW [EC:3.2.1.21] synonym: "limarase activity" NARROW [EC:3.2.1.21] synonym: "p-nitrophenyl beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "primeverosidase activity" NARROW [EC:3.2.1.21] synonym: "salicilinase activity" NARROW [EC:3.2.1.21] xref: EC:3.2.1.21 xref: MetaCyc:3.2.1.21-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0008423 name: bleomycin hydrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40] xref: EC:3.4.22.40 xref: MetaCyc:3.4.22.40-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0008424 name: glycoprotein 6-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+)." [EC:2.4.1.68, RHEA:12988] synonym: "FucT" RELATED [EC:2.4.1.68] synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDPfucose-glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68] synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] xref: EC:2.4.1.68 xref: KEGG:R05988 xref: MetaCyc:2.4.1.68-RXN xref: Reactome:24568 "glycoprotein 6-alpha-L-fucosyltransferase activity" xref: RHEA:12988 is_a: GO:0046921 ! alpha(1,6)-fucosyltransferase activity [Term] id: GO:0008425 name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] subset: gosubset_prok synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT [] synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT [] synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD [] synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD [] xref: EC:2.1.1.- is_a: GO:0030580 ! quinone cofactor methyltransferase activity [Term] id: GO:0008426 name: protein kinase C inhibitor activity namespace: molecular_function alt_id: GO:0004863 def: "Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai] synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT [] synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity" EXACT [] synonym: "PKC inhibitor activity" EXACT [] is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity [Term] id: GO:0008427 name: calcium-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity is_a: GO:0010858 ! calcium-dependent protein kinase regulator activity [Term] id: GO:0008428 name: ribonuclease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai] subset: gosubset_prok is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0008429 name: phosphatidylethanolamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0008430 name: selenium binding namespace: molecular_function def: "Interacting selectively and non-covalently with selenium (Se)." [GOC:ai] subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0008431 name: vitamin E binding namespace: molecular_function def: "Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [CHEBI:33234, GOC:curators, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "alpha-tocopherol binding" NARROW [] synonym: "tocopherol binding" EXACT [] is_a: GO:0019842 ! vitamin binding [Term] id: GO:0008432 name: JUN kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl] synonym: "JNK binding" EXACT [GOC:BHF, GOC:ebc] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0008434 name: vitamin D3 receptor activity namespace: molecular_function def: "Combining with vitamin D3, cholecalciferol, to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. synonym: "cholecaliferol receptor activity" EXACT [] is_a: GO:0004879 ! ligand-dependent nuclear receptor activity [Term] id: GO:0008435 name: anticoagulant activity namespace: molecular_function def: "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0050819 [Term] id: GO:0008436 name: heterogeneous nuclear ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "hnRNP" EXACT [] is_obsolete: true replaced_by: GO:0030530 [Term] id: GO:0008437 name: thyrotropin-releasing hormone activity namespace: molecular_function def: "The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "thyrotropin releasing hormone activity" EXACT [] synonym: "TRH activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0008438 name: 1-phosphatidylinositol-5-phosphate kinase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide." [EC:2.7.1.143] comment: This term was made obsolete because it is a redundant grouping term with only one child. It is also incorrectly defined and had an incorrect EC dbxref. is_obsolete: true consider: GO:0016309 [Term] id: GO:0008439 name: monophenol monooxygenase activator activity namespace: molecular_function def: "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "prophenol oxidase activator" RELATED [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008440 name: inositol trisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023] synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.127] synonym: "inositol 1,4,5-trisphosphate 3-kinase activity" EXACT [] synonym: "inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ins(1,4,5)P(3) 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "Ins(1,4,5)P3 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127] synonym: "IP3K activity" NARROW [EC:2.7.1.127] xref: EC:2.7.1.127 xref: KEGG:R03433 xref: MetaCyc:2.7.1.127-RXN xref: RHEA:11023 is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0008441 name: 3'(2'),5'-bisphosphate nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7] subset: gosubset_prok synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT [] synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" EXACT [EC:3.1.3.7] synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "DPNPase activity" EXACT [EC:3.1.3.7] synonym: "phosphoadenylate 3'-nucleotidase activity" EXACT [EC:3.1.3.7] xref: EC:3.1.3.7 xref: MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN xref: Reactome:24620 "3'(2'),5'-bisphosphate nucleotidase activity" is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008442 name: 3-hydroxyisobutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31] subset: gosubset_prok xref: EC:1.1.1.31 xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN xref: Reactome:24621 "3-hydroxyisobutyrate dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008443 name: phosphofructokinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule." [GOC:jl] subset: gosubset_prok xref: EC:2.7.1.- is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008444 name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+)." [EC:2.7.8.5, RHEA:12596] subset: gosubset_prok synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol 3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerophosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "PGP synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerolphosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] xref: EC:2.7.8.5 xref: KEGG:R01801 xref: MetaCyc:PHOSPHAGLYPSYN-RXN xref: RHEA:12596 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0008445 name: D-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide." [EC:1.4.3.1] synonym: "aspartic oxidase activity" EXACT [EC:1.4.3.1] synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.1] synonym: "D-aspartic oxidase activity" EXACT [EC:1.4.3.1] xref: EC:1.4.3.1 xref: MetaCyc:D-ASPARTATE-OXIDASE-RXN is_a: GO:0015922 ! aspartate oxidase activity [Term] id: GO:0008446 name: GDP-mannose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O." [EC:4.2.1.47, RHEA:23823] subset: gosubset_prok synonym: "GDP-D-mannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-D-mannose dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.47] synonym: "GDPmannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "Gmd" RELATED [EC:4.2.1.47] synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose oxidoreductase activity" EXACT [EC:4.2.1.47] xref: EC:4.2.1.47 xref: KEGG:R00888 xref: MetaCyc:GDPMANDEHYDRA-RXN xref: RHEA:23823 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008447 name: L-ascorbate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3] synonym: "AA oxidase activity" EXACT [EC:1.10.3.3] synonym: "AAO" RELATED [EC:1.10.3.3] synonym: "ascorbase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate dehydrogenase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic oxidase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:O2 oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] xref: EC:1.10.3.3 xref: MetaCyc:L-ASCORBATE-OXIDASE-RXN is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008448 name: N-acetylglucosamine-6-phosphate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25] subset: gosubset_prok synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylglucosamine phosphate deacetylase activity" EXACT [EC:3.5.1.25] synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] xref: EC:3.5.1.25 xref: MetaCyc:NAG6PDEACET-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008449 name: N-acetylglucosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14] subset: gosubset_prok synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "acetylglucosamine 6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14] synonym: "glucosamine-6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT [] synonym: "O,N-disulfate O-sulfohydrolase activity" EXACT [EC:3.1.6.14] xref: EC:3.1.6.14 xref: MetaCyc:3.1.6.14-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0008450 name: O-sialoglycoprotein endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [EC:3.4.24.57] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "glycophorin A proteinase activity" EXACT [EC:3.4.24.57] synonym: "glycoprotease activity" RELATED [EC:3.4.24.57] synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57] synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57] synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57] xref: EC:3.4.24.57 xref: MetaCyc:3.4.24.57-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008451 name: X-Pro aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminoacylproline aminopeptidase activity" EXACT [EC:3.4.11.9] synonym: "aminopeptidase P" EXACT [] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9] synonym: "Xaa-Pro aminopeptidase activity" EXACT [] xref: EC:3.4.11.9 xref: MetaCyc:3.4.11.9-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0008452 name: RNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another." [GOC:mah] subset: gosubset_prok xref: EC:6.5.1.- is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds [Term] id: GO:0008453 name: alanine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44] subset: gosubset_prok synonym: "AGT activity" EXACT [EC:2.6.1.44] synonym: "alanine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "alanine-glyoxylate aminotransferase activity" EXACT [] synonym: "alanine-glyoxylic aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine-glycine transaminase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] xref: EC:2.6.1.44 xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN xref: Reactome:24651 "alanine-glyoxylate transaminase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008454 name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145] synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "beta-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "GnTIV activity" EXACT [EC:2.4.1.145] synonym: "N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145] xref: EC:2.4.1.145 xref: MetaCyc:2.4.1.145-RXN xref: Reactome:24653 "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008455 name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143] synonym: "acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTII activity" EXACT [EC:2.4.1.143] synonym: "N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha-1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] xref: EC:2.4.1.143 xref: MetaCyc:2.4.1.143-RXN xref: Reactome:24654 "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008456 name: alpha-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49] synonym: "alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49] synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.49] synonym: "alpha-NAGA activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49] xref: EC:3.2.1.49 xref: MetaCyc:3.2.1.49-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0008457 name: beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [EC:2.4.1.163] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.163] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.163] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.163] xref: EC:2.4.1.163 xref: MetaCyc:2.4.1.163-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008458 name: carnitine O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA." [EC:2.3.1.137, RHEA:17180] synonym: "carnitine medium-chain acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] synonym: "medium-chain/long-chain carnitine acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" EXACT [EC:2.3.1.137] synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] xref: EC:2.3.1.137 xref: KEGG:R03779 xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN xref: Reactome:24659 "carnitine O-octanoyltransferase activity" xref: RHEA:17180 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016414 ! O-octanoyltransferase activity [Term] id: GO:0008459 name: chondroitin 6-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-O-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-sulphotransferase activity" EXACT [] synonym: "terminal 6-sulfotransferase activity" EXACT [EC:2.8.2.17] xref: EC:2.8.2.17 xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN is_a: GO:0034481 ! chondroitin sulfotransferase activity [Term] id: GO:0008460 name: dTDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17224] subset: gosubset_prok synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.46] synonym: "dTDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "TDP-glucose oxidoreductase activity" EXACT [EC:4.2.1.46] synonym: "thymidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.46] xref: EC:4.2.1.46 xref: KEGG:R06513 xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN xref: RHEA:17224 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008462 name: endopeptidase Clp activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [EC:3.4.21.92] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "ATP-dependent Clp protease" NARROW [EC:3.4.21.92] synonym: "caseinolytic protease activity" RELATED [EC:3.4.21.92] synonym: "Clp protease" NARROW [EC:3.4.21.92] synonym: "ClpP" RELATED [EC:3.4.21.92] synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92] synonym: "protease Ti activity" RELATED [EC:3.4.21.92] xref: EC:3.4.21.92 xref: MetaCyc:3.4.21.92-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008463 name: formylmethionine deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-methionine + H(2)O = L-methionine + formate." [EC:3.5.1.31, RHEA:17784] subset: gosubset_prok synonym: "N-formyl-L-methionine amidohydrolase activity" EXACT [EC:3.5.1.31] xref: EC:3.5.1.31 xref: KEGG:R00653 xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN xref: RHEA:17784 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008464 name: gamma-glutamyl hydrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9] synonym: "conjugase activity" RELATED [EC:3.4.19.9] synonym: "folate conjugase activity" RELATED [EC:3.4.19.9] synonym: "folic acid conjugase activity" EXACT [EC:3.4.19.9] synonym: "gamma-Glu-X carboxypeptidase activity" EXACT [EC:3.4.19.9] synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9] synonym: "poly(gamma-glutamic acid) endohydrolase activity" EXACT [EC:3.4.19.9] synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9] synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9] synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] xref: EC:3.4.19.9 xref: MetaCyc:3.4.19.9-RXN is_obsolete: true replaced_by: GO:0008242 [Term] id: GO:0008465 name: glycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+." [EC:1.1.1.29] subset: gosubset_prok synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29] xref: EC:1.1.1.29 xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008466 name: glycogenin glucosyltransferase activity namespace: molecular_function alt_id: GO:0047210 def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186] synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT [] synonym: "alpha-1,4-glucan-protein synthase (UDP-forming) activity" EXACT [] synonym: "glycogenin activity" RELATED [EC:2.4.1.186] synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186] synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.186] synonym: "UDP-glucose:glycogenin glucosyltransferase activity" EXACT [EC:2.4.1.186] xref: EC:2.4.1.186 xref: MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN xref: Reactome:24685 "glycogenin glucosyltransferase activity" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008467 name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "3-OST-1 activity" EXACT [EC:2.8.2.23] synonym: "glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparin-glucosamine 3-O-sulfotransferase activity" RELATED [] synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED [] synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23] xref: EC:2.8.2.23 xref: MetaCyc:2.8.2.23-RXN is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0008469 name: histone-arginine N-methyltransferase activity namespace: molecular_function alt_id: GO:0016276 def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [EC:2.1.1.125] synonym: "histone methyltransferase activity" BROAD [] synonym: "histone protein methylase activity" EXACT [EC:2.1.1.125] synonym: "histone protein methylase I" RELATED [EC:2.1.1.125] synonym: "histone-arginine N-methylase activity" EXACT [GOC:mah] synonym: "nuclear protein (histone) N-methyltransferase activity" EXACT [EC:2.1.1.125] synonym: "protein methylase I activity" BROAD [EC:2.1.1.125] synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.125] synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.125] xref: EC:2.1.1.125 xref: MetaCyc:2.1.1.125-RXN is_a: GO:0016274 ! protein-arginine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity [Term] id: GO:0008470 name: isovaleryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.99.10] subset: gosubset_prok synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.10] synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.10] synonym: "isovaleroyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] synonym: "isovaleryl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] xref: EC:1.3.99.10 xref: MetaCyc:ISOVALERYL-COA-FAD-RXN xref: Reactome:24705 "isovaleryl-CoA dehydrogenase activity" is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0008471 name: laccase activity namespace: molecular_function def: "Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2] subset: gosubset_prok synonym: "benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.2] synonym: "p-diphenol oxidase activity" EXACT [EC:1.10.3.2] synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2] synonym: "urushiol oxidase activity" EXACT [EC:1.10.3.2] xref: EC:1.10.3.2 xref: MetaCyc:LACCASE-RXN xref: UM-BBD_enzymeID:e0629 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008472 name: metallocarboxypeptidase D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22] synonym: "gp180 (duck)" RELATED [EC:3.4.17.22] xref: EC:3.4.17.22 xref: MetaCyc:3.4.17.22-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0008473 name: ornithine cyclodeaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+)." [EC:4.3.1.12, RHEA:24371] subset: gosubset_prok synonym: "L-ornithine ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.12] synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" EXACT [EC:4.3.1.12] synonym: "OCD activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase (deaminating) activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase activity" EXACT [EC:4.3.1.12] xref: EC:4.3.1.12 xref: KEGG:R00671 xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN xref: RHEA:24371 is_a: GO:0016841 ! ammonia-lyase activity is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008474 name: palmitoyl-(protein) hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22] synonym: "palmitoyl-protein hydrolase activity" EXACT [] synonym: "palmitoyl-protein thioesterase activity" EXACT [] synonym: "palmitoyl-protein thiolesterase activity" EXACT [] xref: EC:3.1.2.22 xref: MetaCyc:3.1.2.22-RXN xref: Reactome:24711 "palmitoyl-(protein) hydrolase activity" is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0008475 name: procollagen-lysine 5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4] synonym: "collagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4] synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.4] synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.11.4] synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4] xref: EC:1.14.11.4 xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity [Term] id: GO:0008476 name: protein-tyrosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20] synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" EXACT [EC:2.8.2.20] synonym: "protein-tyrosine sulphotransferase activity" EXACT [] synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20] xref: EC:2.8.2.20 xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0008477 name: purine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1] subset: gosubset_prok synonym: "IAG-NH activity" RELATED [EC:3.2.2.1] synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1] synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1] synonym: "N-D-ribosylpurine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "N-ribosyl purine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "nucleosidase activity" BROAD [EC:3.2.2.1] synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1] synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1] synonym: "purine beta-ribosidase activity" EXACT [EC:3.2.2.1] synonym: "purine nucleosidase reaction" EXACT [] synonym: "purine nucleoside hydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine ribonucleosidase activity" EXACT [EC:3.2.2.1] synonym: "purine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1] xref: EC:3.2.2.1 xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008478 name: pyridoxal kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] subset: gosubset_prok synonym: "ATP:pyridoxal 5'-phosphotransferase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal 5-phosphate-kinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal kinase (phosphorylating)" EXACT [EC:2.7.1.35] synonym: "pyridoxal phosphokinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35] synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35] xref: EC:2.7.1.35 xref: MetaCyc:PYRIDOXKIN-RXN xref: Reactome:24718 "pyridoxal kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008479 name: queuine tRNA-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29] subset: gosubset_prok synonym: "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "guanine insertion enzyme activity" RELATED [EC:2.4.2.29] synonym: "guanine, queuine-tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "Q-insertase activity" EXACT [EC:2.4.2.29] synonym: "queuine transfer ribonucleate ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "transfer ribonucleate glycosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "tRNA guanine transglycosidase activity" EXACT [EC:2.4.2.29] synonym: "tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29] xref: EC:2.4.2.29 xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0008480 name: sarcosine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + H(2)O + sarcosine = AH(2) + formaldehyde + glycine." [EC:1.5.99.1, RHEA:19796] subset: gosubset_prok synonym: "monomethylglycine dehydrogenase activity" EXACT [EC:1.5.99.1] synonym: "sarcosine N-demethylase activity" EXACT [EC:1.5.99.1] synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.1] synonym: "sarcosine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.1] xref: EC:1.5.99.1 xref: KEGG:R00611 xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN xref: RHEA:19796 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0008481 name: sphinganine kinase activity namespace: molecular_function alt_id: GO:0001728 def: "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [EC:2.7.1.91] synonym: "ATP:sphinganine 1-phosphotransferase activity" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase activity" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase activity" RELATED [] xref: EC:2.7.1.91 xref: MetaCyc:SPHINGANINE-KINASE-RXN xref: Reactome:24730 "sphinganine kinase activity" is_a: GO:0001727 ! lipid kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008482 name: sulfite oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate." [EC:1.8.3.1, RHEA:24603] subset: gosubset_prok synonym: "sulfite:oxygen oxidoreductase activity" EXACT [EC:1.8.3.1] synonym: "sulphite oxidase activity" EXACT [] xref: EC:1.8.3.1 xref: KEGG:R00533 xref: MetaCyc:PWY-5326 xref: MetaCyc:SULFITE-OXIDASE-RXN xref: RHEA:24603 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0008483 name: transaminase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminotransferase activity" EXACT [] xref: EC:2.6.1 is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0008484 name: sulfuric ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] subset: gosubset_prok synonym: "sulfatase activity" EXACT [] synonym: "sulphuric ester hydrolase activity" EXACT [] xref: EC:3.1.6 xref: MetaCyc:ARYLSULFAT-RXN is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0008486 name: diphosphoinositol-polyphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52] synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.52e] synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT [] synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.52e] synonym: "DIPP activity" EXACT [EC:3.6.1.52e] xref: EC:3.6.1.52 xref: MetaCyc:3.6.1.52-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008487 name: prenyl-dependent CAAX protease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008488 name: gamma-glutamyl carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194] subset: gosubset_prok xref: EC:4.1.1.- xref: Reactome:24735 "gamma-glutamyl carboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008489 name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base." [MetaCyc:RXN-10764, PMID:9593693] synonym: "LacCer synthase activity" EXACT [] synonym: "lactosylceramide synthase activity" EXACT [] synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT [] xref: MetaCyc:RXN-10764 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008490 name: arsenite secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0008491 def: "Catalysis of the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl] subset: gosubset_prok synonym: "arsenite porter activity" RELATED [] is_a: GO:0015105 ! arsenite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008492 name: cAMP generating peptide activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product. synonym: "cyclic AMP generating peptide activity" EXACT [] is_obsolete: true consider: GO:0004016 consider: GO:0005179 consider: GO:0046058 [Term] id: GO:0008493 name: tetracycline transporter activity namespace: molecular_function def: "Enables the directed movement of tetracycline into, out of or within a cell, or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:curators] subset: gosubset_prok synonym: "tetracyclin transporter activity" EXACT [] is_a: GO:0042895 ! antibiotic transporter activity [Term] id: GO:0008494 name: translation activator activity namespace: molecular_function def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai] is_a: GO:0090079 ! translation regulator activity, nucleic acid binding [Term] id: GO:0008495 name: protoheme IX farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate." [MetaCyc:HEMEOSYN-RXN] subset: gosubset_prok synonym: "haem O synthase activity" EXACT [] synonym: "heme A:farnesyltransferase activity" EXACT [PMID:9177788] synonym: "heme O synthase activity" EXACT [] synonym: "protohaem IX farnesyltransferase activity" EXACT [] xref: EC:2.5.1.- xref: MetaCyc:HEMEOSYN-RXN is_a: GO:0004311 ! farnesyltranstransferase activity [Term] id: GO:0008496 name: mannan endo-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,6-alpha-D-mannosidic linkages in unbranched 1,6-mannans." [EC:3.2.1.101] synonym: "1,6-alpha-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "1,6-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "endo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-1->6-D-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-D-mannosidase activity" EXACT [] synonym: "exo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "mannan endo-1,6-beta-mannosidase activity" EXACT [EC:3.2.1.101] xref: EC:3.2.1.101 xref: MetaCyc:3.2.1.101-RXN is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0008498 name: phospholipid scrambling namespace: molecular_function def: "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions." [OMIM:604170] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true replaced_by: GO:0017121 [Term] id: GO:0008499 name: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP." [PMID:10212226] synonym: "beta-1,3-GalTase activity" BROAD [] synonym: "beta3Gal-Ts activity" BROAD [] synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT [] is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity [Term] id: GO:0008500 name: glycine-, glutamate-, thienylcyclohexylpiperidine binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a conglomeration of three terms. is_obsolete: true consider: GO:0016594 consider: GO:0016595 consider: GO:0016596 [Term] id: GO:0008502 name: melatonin receptor activity namespace: molecular_function def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0008503 name: benzodiazepine receptor activity namespace: molecular_function def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0008504 name: monoamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015201 def: "Catalysis of the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other." [CHEBI:25375, GOC:mah] xref: Reactome:22834 "monoamine transmembrane transporter activity" is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0008506 name: sucrose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3] synonym: "hydrogen/sucrose transporter activity" BROAD [] synonym: "sucrose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0008515 ! sucrose transmembrane transporter activity [Term] id: GO:0008507 name: sodium:iodide symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1] synonym: "sodium/iodide symporter activity" EXACT [] xref: Reactome:24854 "sodium:iodide symporter activity" is_a: GO:0015373 ! monovalent anion:sodium symporter activity [Term] id: GO:0008508 name: bile acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-] synonym: "sodium/bile acid symporter activity" EXACT [] xref: Reactome:24856 "bile acid:sodium symporter activity" is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0015125 ! bile acid transmembrane transporter activity [Term] id: GO:0008509 name: anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "anion transporter activity" EXACT [] xref: Reactome:3160 "anion transmembrane transporter activity" is_a: GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0008510 name: sodium:bicarbonate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1] synonym: "sodium/bicarbonate cotransporter activity" BROAD [] synonym: "sodium:bicarbonate cotransporter activity" BROAD [] xref: Reactome:24874 "sodium:bicarbonate symporter activity" is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015106 ! bicarbonate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0008511 name: sodium:potassium:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1] synonym: "sodium/potassium/chloride symporter activity" EXACT [] xref: Reactome:24875 "sodium:potassium:chloride symporter activity" is_a: GO:0015377 ! cation:chloride symporter activity [Term] id: GO:0008512 name: sulfate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-] synonym: "sulfate/hydrogen symporter activity" EXACT [] synonym: "sulfate:proton symporter activity" EXACT [] synonym: "sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0008513 name: secondary active organic cation transmembrane transporter activity namespace: molecular_function alt_id: GO:0015354 def: "Catalysis of the transfer of organic cations from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:curators] synonym: "organic cation porter activity" RELATED [] synonym: "polyspecific organic cation transmembrane transporter activity" NARROW [] xref: Reactome:14026 "secondary active organic cation transmembrane transporter activity" is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008514 name: organic anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] subset: gosubset_prok is_a: GO:0008509 ! anion transmembrane transporter activity [Term] id: GO:0008515 name: sucrose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019188 def: "Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "sucrose permease (PTS) activity" EXACT [] synonym: "sucrose permease activity" RELATED [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0008516 name: hexose uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5] is_a: GO:0015149 ! hexose transmembrane transporter activity is_a: GO:0015292 ! uniporter activity [Term] id: GO:0008517 name: folic acid transporter activity namespace: molecular_function def: "Enables the directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transporter activity" EXACT [] synonym: "vitamin B9 transporter activity" EXACT [] synonym: "vitamin M transporter activity" EXACT [] xref: Reactome:21930 "folic acid transporter activity" is_a: GO:0051183 ! vitamin transporter activity is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0008518 name: reduced folate carrier activity namespace: molecular_function def: "Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "reduced folate transporter" BROAD [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008519 name: ammonium transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:23077 "ammonium transmembrane transporter activity" is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0008520 name: L-ascorbate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in)." [TC:2.A.40.6.1] synonym: "sodium-dependent L-ascorbic acid transporter" RELATED [] is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0008521 name: acetyl-CoA transporter activity namespace: molecular_function def: "Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] xref: Reactome:22871 "acetyl-CoA transporter activity" is_a: GO:0051185 ! coenzyme transporter activity [Term] id: GO:0008523 name: sodium-dependent multivitamin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2] xref: Reactome:24902 "sodium-dependent multivitamin transmembrane transporter activity" is_a: GO:0015370 ! solute:sodium symporter activity is_a: GO:0051183 ! vitamin transporter activity [Term] id: GO:0008524 name: glucose 6-phosphate:phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)." [TC:2.A.1.-.-] is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity relationship: part_of GO:0005355 ! glucose transmembrane transporter activity [Term] id: GO:0008525 name: phosphatidylcholine transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0008526 name: phosphatidylinositol transporter activity namespace: molecular_function def: "Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "phosphatidylinositol transfer" EXACT [] is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0008527 name: taste receptor activity namespace: molecular_function def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] synonym: "gustatory receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0008528 name: peptide receptor activity, G-protein coupled namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [GOC:dph, GOC:tb] synonym: "G protein coupled peptide receptor activity" EXACT [] synonym: "G-protein coupled peptide receptor activity" EXACT [] synonym: "G-protein-coupled peptide receptor activity" EXACT [] synonym: "peptide receptor activity, G protein coupled" EXACT [] is_a: GO:0001653 ! peptide receptor activity is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0008529 name: endogenous peptide receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0001653 consider: GO:0005622 [Term] id: GO:0008530 name: exogenous peptide receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0001653 consider: GO:0005576 [Term] id: GO:0008531 name: riboflavin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+)." [EC:2.7.1.26, RHEA:14360] subset: gosubset_prok synonym: "ATP:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.26] synonym: "FK" RELATED [EC:2.7.1.26] synonym: "flavokinase activity" EXACT [EC:2.7.1.26] synonym: "riboflavin kinase (phosphorylating)" EXACT [EC:2.7.1.26] synonym: "riboflavine kinase activity" EXACT [EC:2.7.1.26] xref: EC:2.7.1.26 xref: KEGG:R00549 xref: MetaCyc:RIBOFLAVINKIN-RXN xref: Reactome:24927 "riboflavin kinase activity" xref: RHEA:14360 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008532 name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "GnTE activity" EXACT [EC:2.4.1.149] synonym: "N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149] synonym: "UDP-GlcNAc:Galbeta1->4GlcNAcbeta-rbeta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] xref: EC:2.4.1.149 xref: MetaCyc:2.4.1.149-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008533 name: astacin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [EC:3.4.24.21] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21] synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21] synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21] xref: EC:3.4.24.21 xref: MetaCyc:3.4.24.21-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008534 name: oxidized purine base lesion DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0003907 def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. subset: gosubset_prok synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "8-oxoguanine DNA glycosylase activity" BROAD [] synonym: "bifunctional DNA glycosylase activity" BROAD [] synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23] synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23] synonym: "DNA glycosylase/AP-lyase activity" BROAD [] synonym: "DNA glycosylase/beta-lyase activity" BROAD [] synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT [] synonym: "fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT [] synonym: "Fpg protein" RELATED [EC:3.2.2.23] synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: EC:3.2.2.23 xref: MetaCyc:3.2.2.23-RXN xref: Reactome:24932 "oxidized purine base lesion DNA N-glycosylase activity" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity [Term] id: GO:0008535 name: respiratory chain complex IV assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm] subset: gosubset_prok synonym: "cytochrome c oxidase biogenesis" BROAD [] synonym: "cytochrome c oxidase complex assembly" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0008536 name: Ran GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly." [GOC:rn, PMID:12787777, PMID:14726649] synonym: "Ran protein binding" EXACT [] synonym: "Ran-binding protein" RELATED [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0008537 name: proteasome activator complex namespace: cellular_component def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb] synonym: "PA28" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0008538 name: proteasome activator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "PA28" NARROW [] is_obsolete: true consider: GO:0061133 consider: GO:0061136 [Term] id: GO:0008539 name: proteasome inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:mah] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "PI-31" NARROW [] is_obsolete: true consider: GO:0004866 consider: GO:0061136 [Term] id: GO:0008540 name: proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005838 ! proteasome regulatory particle [Term] id: GO:0008541 name: proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005838 ! proteasome regulatory particle [Term] id: GO:0008542 name: visual learning namespace: biological_process def: "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089] synonym: "spatial learning" RELATED [] is_a: GO:0007632 ! visual behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0008543 name: fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "FGF receptor signaling pathway" EXACT [] synonym: "FGF receptor signalling pathway" EXACT [] synonym: "FGFR signaling pathway" EXACT [] synonym: "fibroblast growth factor receptor signalling pathway" EXACT [] xref: Reactome:1253118 "Signaling by FGFR" xref: Reactome:1253433 "FGFR1b ligand binding and activation" xref: Reactome:1253434 "FGFR1 ligand binding and activation" xref: Reactome:1253435 "FGFR ligand binding and activation" xref: Reactome:1253436 "FGFR1c ligand binding and activation" xref: Reactome:1253437 "FGFR2c ligand binding and activation" xref: Reactome:1253438 "FGFR2 ligand binding and activation" xref: Reactome:1253439 "FGFR2b ligand binding and activation" xref: Reactome:1253440 "FGFR3c ligand binding and activation" xref: Reactome:1253441 "FGFR3 ligand binding and activation" xref: Reactome:1253442 "FGFR3b ligand binding and activation" xref: Reactome:1253443 "FGFR4 ligand binding and activation" xref: Reactome:1253444 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:1280053 "Signaling by FGFR" xref: Reactome:1280371 "FGFR1b ligand binding and activation" xref: Reactome:1280372 "FGFR1 ligand binding and activation" xref: Reactome:1280373 "FGFR ligand binding and activation" xref: Reactome:1280374 "FGFR1c ligand binding and activation" xref: Reactome:1280375 "FGFR2c ligand binding and activation" xref: Reactome:1280376 "FGFR2 ligand binding and activation" xref: Reactome:1280377 "FGFR2b ligand binding and activation" xref: Reactome:1280378 "FGFR3c ligand binding and activation" xref: Reactome:1280379 "FGFR3 ligand binding and activation" xref: Reactome:1280380 "FGFR3b ligand binding and activation" xref: Reactome:1280381 "FGFR4 ligand binding and activation" xref: Reactome:1280382 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:1298940 "Signaling by FGFR" xref: Reactome:1299208 "FGFR1b ligand binding and activation" xref: Reactome:1299209 "FGFR1 ligand binding and activation" xref: Reactome:1299210 "FGFR ligand binding and activation" xref: Reactome:1299211 "FGFR1c ligand binding and activation" xref: Reactome:1299212 "FGFR2c ligand binding and activation" xref: Reactome:1299213 "FGFR2 ligand binding and activation" xref: Reactome:1299214 "FGFR2b ligand binding and activation" xref: Reactome:1299215 "FGFR3c ligand binding and activation" xref: Reactome:1299216 "FGFR3 ligand binding and activation" xref: Reactome:1299217 "FGFR3b ligand binding and activation" xref: Reactome:1299218 "FGFR4 ligand binding and activation" xref: Reactome:1299219 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:1326623 "Signaling by FGFR" xref: Reactome:1326949 "FGFR1b ligand binding and activation" xref: Reactome:1326950 "FGFR1 ligand binding and activation" xref: Reactome:1326951 "FGFR ligand binding and activation" xref: Reactome:1326952 "FGFR1c ligand binding and activation" xref: Reactome:1326953 "FGFR2c ligand binding and activation" xref: Reactome:1326954 "FGFR2 ligand binding and activation" xref: Reactome:1326955 "FGFR2b ligand binding and activation" xref: Reactome:1326956 "FGFR3c ligand binding and activation" xref: Reactome:1326957 "FGFR3 ligand binding and activation" xref: Reactome:1326958 "FGFR3b ligand binding and activation" xref: Reactome:1326959 "FGFR4 ligand binding and activation" xref: Reactome:1326960 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:1352736 "Signaling by FGFR" xref: Reactome:1353044 "FGFR1b ligand binding and activation" xref: Reactome:1353045 "FGFR1 ligand binding and activation" xref: Reactome:1353046 "FGFR ligand binding and activation" xref: Reactome:1353047 "FGFR1c ligand binding and activation" xref: Reactome:1353048 "FGFR2c ligand binding and activation" xref: Reactome:1353049 "FGFR2 ligand binding and activation" xref: Reactome:1353050 "FGFR2b ligand binding and activation" xref: Reactome:1353051 "FGFR3c ligand binding and activation" xref: Reactome:1353052 "FGFR3 ligand binding and activation" xref: Reactome:1353053 "FGFR3b ligand binding and activation" xref: Reactome:1353054 "FGFR4 ligand binding and activation" xref: Reactome:1353055 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:1372947 "Signaling by FGFR" xref: Reactome:1373235 "FGFR1b ligand binding and activation" xref: Reactome:1373236 "FGFR1 ligand binding and activation" xref: Reactome:1373237 "FGFR ligand binding and activation" xref: Reactome:1373238 "FGFR1c ligand binding and activation" xref: Reactome:1373239 "FGFR2c ligand binding and activation" xref: Reactome:1373240 "FGFR2 ligand binding and activation" xref: Reactome:1373241 "FGFR2b ligand binding and activation" xref: Reactome:1373242 "FGFR3c ligand binding and activation" xref: Reactome:1373243 "FGFR3 ligand binding and activation" xref: Reactome:1373244 "FGFR3b ligand binding and activation" xref: Reactome:1373245 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:1392963 "Signaling by FGFR" xref: Reactome:1393253 "FGFR1b ligand binding and activation" xref: Reactome:1393254 "FGFR1 ligand binding and activation" xref: Reactome:1393255 "FGFR ligand binding and activation" xref: Reactome:1393256 "FGFR1c ligand binding and activation" xref: Reactome:1393257 "FGFR2c ligand binding and activation" xref: Reactome:1393258 "FGFR2 ligand binding and activation" xref: Reactome:1393259 "FGFR2b ligand binding and activation" xref: Reactome:1393260 "FGFR3c ligand binding and activation" xref: Reactome:1393261 "FGFR3 ligand binding and activation" xref: Reactome:1393262 "FGFR3b ligand binding and activation" xref: Reactome:1393263 "FGFR4 ligand binding and activation" xref: Reactome:1393264 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:1417443 "Signaling by FGFR" xref: Reactome:1417745 "FGFR4 ligand binding and activation" xref: Reactome:1417746 "FGFR ligand binding and activation" xref: Reactome:1417748 "FGFR3b ligand binding and activation" xref: Reactome:1417749 "FGFR3 ligand binding and activation" xref: Reactome:1417750 "FGFR3c ligand binding and activation" xref: Reactome:1417752 "FGFR2b ligand binding and activation" xref: Reactome:1417753 "FGFR2 ligand binding and activation" xref: Reactome:1417754 "FGFR2c ligand binding and activation" xref: Reactome:1417755 "FGFR1b ligand binding and activation" xref: Reactome:1417756 "FGFR1 ligand binding and activation" xref: Reactome:1417757 "FGFR1c ligand binding and activation" xref: Reactome:1417770 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:1450536 "Signaling by FGFR" xref: Reactome:1450845 "FGFR1b ligand binding and activation" xref: Reactome:1450846 "FGFR1 ligand binding and activation" xref: Reactome:1450847 "FGFR ligand binding and activation" xref: Reactome:1450848 "FGFR1c ligand binding and activation" xref: Reactome:1450849 "FGFR2c ligand binding and activation" xref: Reactome:1450850 "FGFR2 ligand binding and activation" xref: Reactome:1450851 "FGFR2b ligand binding and activation" xref: Reactome:1450852 "FGFR3c ligand binding and activation" xref: Reactome:1450853 "FGFR3 ligand binding and activation" xref: Reactome:1450854 "FGFR3b ligand binding and activation" xref: Reactome:1450855 "FGFR4 ligand binding and activation" xref: Reactome:1450856 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:1471039 "Signaling by FGFR" xref: Reactome:1471248 "FGFR1c ligand binding and activation" xref: Reactome:1471249 "FGFR1 ligand binding and activation" xref: Reactome:1471250 "FGFR ligand binding and activation" xref: Reactome:1471251 "FGFR2c ligand binding and activation" xref: Reactome:1471252 "FGFR2 ligand binding and activation" xref: Reactome:1471253 "FGFR3c ligand binding and activation" xref: Reactome:1471254 "FGFR3 ligand binding and activation" xref: Reactome:1471255 "FGFR3b ligand binding and activation" xref: Reactome:1471256 "FGFR4 ligand binding and activation" xref: Reactome:190236 "Signaling by FGFR" xref: Reactome:190239 "FGFR3 ligand binding and activation" xref: Reactome:190241 "FGFR2 ligand binding and activation" xref: Reactome:190242 "FGFR1 ligand binding and activation" xref: Reactome:190322 "FGFR4 ligand binding and activation" xref: Reactome:190370 "FGFR1b ligand binding and activation" xref: Reactome:190371 "FGFR3b ligand binding and activation" xref: Reactome:190372 "FGFR3c ligand binding and activation" xref: Reactome:190373 "FGFR1c ligand binding and activation" xref: Reactome:190374 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:190375 "FGFR2c ligand binding and activation" xref: Reactome:190376 "FGFR ligand binding and activation" xref: Reactome:190377 "FGFR2b ligand binding and activation" is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0008544 name: epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0008545 name: JUN kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549] synonym: "JNKK" EXACT [] xref: EC:2.7.11.- xref: Reactome:24962 "JUN kinase kinase activity" is_a: GO:0004708 ! MAP kinase kinase activity [Term] id: GO:0008546 name: microtubule/chromatin interaction namespace: biological_process def: "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins." [PMID:10322137] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true consider: GO:0003677 consider: GO:0003682 consider: GO:0008017 consider: GO:0030674 [Term] id: GO:0008547 name: protein-synthesizing GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0006412 consider: GO:0008135 [Term] id: GO:0008548 name: signal-recognition-particle GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis." [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0005786 [Term] id: GO:0008549 name: dynamin GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles." [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "dynamine GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0006897 [Term] id: GO:0008550 name: tubulin GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0007021 [Term] id: GO:0008551 name: cadmium-exporting ATPase activity namespace: molecular_function alt_id: GO:0008561 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out)." [EC:3.6.3.3] subset: gosubset_prok synonym: "ATP phosphohydrolase (Cd2+-exporting)" EXACT [EC:3.6.3.3] synonym: "cadmium exporting ATPase activity" EXACT [] synonym: "cadmium-translocating P-type ATPase activity" RELATED [EC:3.6.3.3] synonym: "Cd(2+)-exporting ATPase activity" EXACT [EC:3.6.3.3] synonym: "Cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] synonym: "cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] xref: EC:3.6.3.3 xref: MetaCyc:3.6.3.3-RXN is_a: GO:0015086 ! cadmium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008552 name: zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:3.A.3.6.2] comment: This term was made obsolete because it represents more than one molecular function. is_obsolete: true consider: GO:0005385 consider: GO:0015086 consider: GO:0015087 consider: GO:0015094 consider: GO:0015099 consider: GO:0015662 [Term] id: GO:0008553 name: hydrogen-exporting ATPase activity, phosphorylative mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism." [EC:3.6.3.6] subset: gosubset_prok synonym: "ATP phosphohydrolase (H+-exporting)" EXACT [EC:3.6.3.6] synonym: "H(+)-exporting ATPase activity" BROAD [EC:3.6.3.6] synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.6] synonym: "H+-exporting ATPase activity" EXACT [EC:3.6.3.6] synonym: "H+-transporting ATPase" BROAD [EC:3.6.3.6] synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT [] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "proton transport ATPase activity" RELATED [EC:3.6.3.6] synonym: "proton-exporting ATPase" RELATED [EC:3.6.3.6] synonym: "proton-translocating ATPase activity" EXACT [EC:3.6.3.6] synonym: "proton-translocating P-type ATPase activity" EXACT [EC:3.6.3.6] synonym: "yeast plasma membrane ATPase" NARROW [EC:3.6.3.6] synonym: "yeast plasma membrane H+-ATPase" NARROW [EC:3.6.3.6] xref: EC:3.6.3.6 xref: MetaCyc:3.6.3.6-RXN is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008554 name: sodium-exporting ATPase activity, phosphorylative mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism." [EC:3.6.3.7] subset: gosubset_prok synonym: "ATP phosphohydrolase (Na+-exporting)" EXACT [EC:3.6.3.7] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "Na(+)-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "Na(+)-transporting ATPase activity" BROAD [EC:3.6.3.7] synonym: "Na+-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "Na+-transporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "sodium exporting ATPase activity, phosphorylative mechanism" EXACT [] synonym: "sodium transport ATPase activity" RELATED [EC:3.6.3.7] synonym: "sodium-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "sodium-translocating P-type ATPase activity" RELATED [EC:3.6.3.7] xref: EC:3.6.3.7 xref: MetaCyc:3.6.3.7-RXN is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008555 name: chloride-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in)." [EC:3.6.3.11] subset: gosubset_prok synonym: "ATP phosphohydrolase (Cl--importing)" EXACT [EC:3.6.3.11] synonym: "chloride ABC transporter" NARROW [] synonym: "chloride transporting ATPase activity" EXACT [] synonym: "chloride-motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "chloride-translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl(-)-transporting ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11] synonym: "cl--transporting ATPase activity" EXACT [EC:3.6.3.11] xref: EC:3.6.3.11 xref: MetaCyc:3.6.3.11-RXN is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008556 name: potassium-transporting ATPase activity namespace: molecular_function alt_id: GO:0015618 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [EC:3.6.3.12] subset: gosubset_prok synonym: "ATP phosphohydrolase (K+-importing)" EXACT [EC:3.6.3.12] synonym: "K(+)-importing ATPase activity" NARROW [EC:3.6.3.12] synonym: "K(+)-transporting ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-importing ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-translocating Kdp-ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-transporting ATPase activity" EXACT [] synonym: "k+-transporting ATPase activity" EXACT [EC:3.6.3.12] synonym: "multi-subunit K+-transport ATPase" NARROW [EC:3.6.3.12] synonym: "potassium ABC transporter" NARROW [] synonym: "potassium transporting ATPase activity" EXACT [] synonym: "potassium-importing ATPase activity" NARROW [EC:3.6.3.12] synonym: "potassium-uptake-ATPase activity" EXACT [] xref: EC:3.6.3.12 is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008558 name: guanine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [EC:3.6.3.37] synonym: "ATP phosphohydrolase (guanine-importing)" EXACT [EC:3.6.3.37] synonym: "guanine ABC transporter" NARROW [] xref: EC:3.6.3.37 xref: MetaCyc:3.6.3.37-RXN is_a: GO:0015208 ! guanine transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0008559 name: xenobiotic-transporting ATPase activity namespace: molecular_function alt_id: GO:0005226 alt_id: GO:0008560 def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] subset: gosubset_prok synonym: "ATP phosphohydrolase (steroid-exporting)" EXACT [EC:3.6.3.44] synonym: "ATP phosphohydrolase (xenobiotic-exporting)" EXACT [EC:3.6.3.44] synonym: "MDR protein" RELATED [EC:3.6.3.44] synonym: "multidrug resistance exporter" RELATED [] synonym: "multidrug-resistance protein" RELATED [] synonym: "P-glycoprotein" RELATED [] synonym: "PDR protein" RELATED [EC:3.6.3.44] synonym: "pleiotropic-drug-resistance protein" RELATED [EC:3.6.3.44] synonym: "steroid ABC transporter" NARROW [] synonym: "steroid-transporting ATPase activity" EXACT [] synonym: "xenobiotic ABC transporter" NARROW [] xref: EC:3.6.3.44 xref: MetaCyc:3.6.3.44-RXN is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances is_a: GO:0042910 ! xenobiotic transporter activity [Term] id: GO:0008563 name: alpha-factor sex pheromone exporter namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process." [EC:3.6.3.48] comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported. synonym: "alpha-factor-transporting ATPase" RELATED [] is_obsolete: true [Term] id: GO:0008564 name: protein-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the concomitant secretion of proteins." [EC:3.6.3.50] synonym: "ATP phosphohydrolase (protein-secreting)" EXACT [EC:3.6.3.50] synonym: "protein-secreting ATPase activity" EXACT [] xref: EC:3.6.3.50 xref: MetaCyc:3.6.3.50-RXN is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity [Term] id: GO:0008565 name: protein transporter activity namespace: molecular_function alt_id: GO:0015463 def: "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "enzyme transporter activity" NARROW [] synonym: "holin" RELATED [] synonym: "protein carrier activity" EXACT [] synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "secretin" RELATED [] is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0008566 name: mitochondrial protein-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51] comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'. synonym: "ATP phosphohydrolase (mitochondrial protein-importing) activity" EXACT [EC:3.6.3.51] xref: EC:3.6.3.51 xref: MetaCyc:3.6.3.51-RXN is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity [Term] id: GO:0008567 name: dynein ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome." [EC:3.6.4.2] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. is_obsolete: true consider: GO:0003777 consider: GO:0007018 [Term] id: GO:0008568 name: microtubule-severing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] comment: See also the cellular component term 'katanin complex ; GO:0008352'. synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [EC:3.6.4.3] synonym: "katanin activity" NARROW [EC:3.6.4.3] xref: EC:3.6.4.3 xref: MetaCyc:3.6.4.3-RXN is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008569 name: minus-end-directed microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.5, GOC:mah] synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [EC:3.6.4.5] synonym: "minus-end-directed kinesin ATPase activity" BROAD [] xref: EC:3.6.4.5 xref: MetaCyc:3.6.4.5-RXN is_a: GO:0003777 ! microtubule motor activity [Term] id: GO:0008570 name: myosin ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction." [EC:3.6.4.1] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. is_obsolete: true replaced_by: GO:0000146 consider: GO:0030048 [Term] id: GO:0008571 name: non-chaperonin molecular chaperone ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin." [EC:3.6.4.10] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0042623 consider: GO:0006457 [Term] id: GO:0008572 name: nucleoplasmin ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." [EC:3.6.4.11] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. is_obsolete: true replaced_by: GO:0042623 consider: GO:0006333 [Term] id: GO:0008573 name: peroxisome-assembly ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle." [EC:3.6.4.7] comment: This term was made obsolete because it incorporates process information. is_obsolete: true replaced_by: GO:0042623 consider: GO:0007031 [Term] id: GO:0008574 name: plus-end-directed microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.4] synonym: "kinesin activity" RELATED [EC:3.6.4.4] synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [EC:3.6.4.4] synonym: "plus-end-directed kinesin ATPase activity" BROAD [] xref: EC:3.6.4.4 xref: MetaCyc:3.6.4.4-RXN is_a: GO:0003777 ! microtubule motor activity [Term] id: GO:0008575 name: proteasome ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." [EC:3.6.4.8] comment: This term was made obsolete because it mentions a component term in the term text string. is_obsolete: true consider: GO:0016887 [Term] id: GO:0008576 name: vesicle-fusing ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments." [EC:3.6.4.6] comment: This term was made obsolete because it incorporates process information. is_obsolete: true replaced_by: GO:0042623 consider: GO:0006944 consider: GO:0016192 [Term] id: GO:0008579 name: JUN kinase phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah] xref: EC:3.1.3.- is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity [Term] id: GO:0008580 name: cytoskeletal regulator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology. is_obsolete: true consider: GO:0007010 [Term] id: GO:0008581 name: ubiquitin-specific protease 5 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001] comment: This term was made obsolete because it represents a gene product. synonym: "ubiquitin isopeptidase T activity" EXACT [] is_obsolete: true replaced_by: GO:0004221 [Term] id: GO:0008582 name: regulation of synaptic growth at neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051963 ! regulation of synaptogenesis relationship: regulates GO:0051124 ! synaptic growth at neuromuscular junction [Term] id: GO:0008583 name: mystery cell differentiation namespace: biological_process def: "The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster." [ISBN:0632030488, PMID:1295747] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0008584 name: male gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid] synonym: "testicular development" EXACT [GOC:sl] synonym: "testis development" EXACT [GOC:sl] is_a: GO:0008406 ! gonad development relationship: part_of GO:0046546 ! development of primary male sexual characteristics [Term] id: GO:0008585 name: female gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:jid] synonym: "ovarian development" RELATED [GOC:sl] synonym: "ovary development" RELATED [GOC:sl] is_a: GO:0008406 ! gonad development relationship: part_of GO:0046545 ! development of primary female sexual characteristics [Term] id: GO:0008586 name: imaginal disc-derived wing vein morphogenesis namespace: biological_process def: "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] synonym: "wing vein morphogenesis" EXACT [] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0008587 name: imaginal disc-derived wing margin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'. synonym: "wing margin morphogenesis" EXACT [] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0008588 name: release of cytoplasmic sequestered NF-kappaB namespace: biological_process def: "The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus." [GOC:jl] synonym: "activation of NF-kappa B" RELATED [] synonym: "negative regulation of cytoplasmic NF-kappaB retention" RELATED [] synonym: "negative regulation of cytoplasmic NF-kappaB sequestering" RELATED [] synonym: "negative regulation of cytoplasmic NF-kappaB sequestration" RELATED [] synonym: "negative regulation of cytoplasmic NF-kappaB storage" RELATED [] synonym: "release of NF-kappaB sequestered in cytoplasm" EXACT [] synonym: "release of NF-kappaB stored in cytoplasm" EXACT [] is_a: GO:0042346 ! positive regulation of NF-kappaB import into nucleus relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0008589 name: regulation of smoothened signaling pathway namespace: biological_process alt_id: GO:0007226 alt_id: GO:0043109 def: "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators] synonym: "regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "regulation of smoothened activity" RELATED [] synonym: "regulation of smoothened by patched" RELATED [] synonym: "regulation of smoothened receptor activity by patched" RELATED [] synonym: "regulation of smoothened signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007224 ! smoothened signaling pathway [Term] id: GO:0008591 name: regulation of Wnt receptor signaling pathway, calcium modulating pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of frizzled-2 signaling pathway" EXACT [] synonym: "regulation of frizzled-2 signalling pathway" EXACT [] is_a: GO:2000050 ! regulation of non-canonical Wnt receptor signaling pathway relationship: regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway [Term] id: GO:0008592 name: regulation of Toll signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] synonym: "regulation of Tl signaling pathway" EXACT [] synonym: "regulation of Tl signalling pathway" EXACT [] synonym: "regulation of Toll signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0008063 ! Toll signaling pathway [Term] id: GO:0008593 name: regulation of Notch signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] synonym: "regulation of N signaling pathway" EXACT [] synonym: "regulation of N signalling pathway" EXACT [] synonym: "regulation of Notch signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007219 ! Notch signaling pathway [Term] id: GO:0008594 name: photoreceptor cell morphogenesis namespace: biological_process def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] synonym: "photoreceptor development" RELATED [] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042461 ! photoreceptor cell development [Term] id: GO:0008595 name: anterior/posterior axis specification, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0007351 ! tripartite regional subdivision [Term] id: GO:0008597 name: calcium-dependent protein serine/threonine phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW [] xref: Reactome:25079 "calcium-dependent protein serine/threonine phosphatase regulator activity" is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0008599 name: protein phosphatase type 1 regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 1." [GOC:ai] synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW [] xref: Reactome:25081 "protein phosphatase type 1 regulator activity" is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0008601 name: protein phosphatase type 2A regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai] synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0008603 name: cAMP-dependent protein kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] subset: gosubset_prok synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT [] synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW [] synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT [] is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0008605 name: protein kinase CK2 regulator activity namespace: molecular_function def: "OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "casein kinase II, regulator" EXACT [] synonym: "protein kinase CK2, intrinsic regulator activity" NARROW [] is_obsolete: true replaced_by: GO:0019887 [Term] id: GO:0008607 name: phosphorylase kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW [] xref: EC:2.7.1.- is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0008608 name: attachment of spindle microtubules to kinetochore namespace: biological_process def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] synonym: "amphotelic attachment" RELATED [] synonym: "bipolar attachment" RELATED [] synonym: "correction of merotelic attachment" NARROW [] synonym: "kinetochore microtubule interaction" BROAD [] synonym: "kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "kinetochore-microtubule interaction" BROAD [] synonym: "microtubule anchoring at kinetochore" EXACT [] synonym: "microtubule and kinetochore interaction" RELATED [] synonym: "microtubule capture" NARROW [] synonym: "prevention of merotelic attachment" NARROW [] synonym: "spindle kinetochore attachment" EXACT [] is_a: GO:0051313 ! attachment of spindle microtubules to chromosome [Term] id: GO:0008609 name: alkylglycerone-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26] subset: gosubset_prok synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" EXACT [EC:2.5.1.26] synonym: "alkyl DHAP synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26] synonym: "alkyl-DHAP synthase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetone phosphate synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetonephosphate synthase activity" EXACT [EC:2.5.1.26] synonym: "DHAP-AT" RELATED [EC:2.5.1.26] synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.26] xref: EC:2.5.1.26 xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN xref: Reactome:25371 "alkylglycerone-phosphate synthase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008610 name: lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] subset: gosubset_prok synonym: "lipid anabolism" EXACT [] synonym: "lipid biosynthesis" EXACT [] synonym: "lipid formation" EXACT [] synonym: "lipid synthesis" EXACT [] synonym: "lipogenesis" EXACT [GOC:sl] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0009058 ! biosynthetic process [Term] id: GO:0008611 name: ether lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120] subset: gosubset_prok synonym: "ether lipid anabolism" EXACT [] synonym: "ether lipid biosynthesis" EXACT [] synonym: "ether lipid formation" EXACT [] synonym: "ether lipid synthesis" EXACT [] synonym: "plasmalogen biosynthetic process" NARROW [] xref: Reactome:1253070 "Plasmalogen biosynthesis" xref: Reactome:1280005 "Plasmalogen biosynthesis" xref: Reactome:1298895 "Plasmalogen biosynthesis" xref: Reactome:1326575 "Plasmalogen biosynthesis" xref: Reactome:1352687 "Plasmalogen biosynthesis" xref: Reactome:1372904 "Plasmalogen biosynthesis" xref: Reactome:1392919 "Plasmalogen biosynthesis" xref: Reactome:1417396 "Plasmalogen biosynthesis" xref: Reactome:1450494 "Plasmalogen biosynthesis" xref: Reactome:1471007 "Plasmalogen biosynthesis" xref: Reactome:1483033 "Plasmalogen biosynthesis" xref: Reactome:1497052 "Plasmalogen biosynthesis" xref: Reactome:1514439 "Plasmalogen biosynthesis" xref: Reactome:1521028 "Plasmalogen biosynthesis" xref: Reactome:75896 "Plasmalogen biosynthesis" is_a: GO:0045017 ! glycerolipid biosynthetic process is_a: GO:0046485 ! ether lipid metabolic process is_a: GO:0046504 ! glycerol ether biosynthetic process [Term] id: GO:0008612 name: peptidyl-lysine modification to hypusine namespace: biological_process alt_id: GO:0046515 def: "The modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116] subset: gosubset_prok synonym: "hypusine anabolism" EXACT [] synonym: "hypusine anabolism from peptidyl-lysine" EXACT [] synonym: "hypusine biosynthesis" EXACT [] synonym: "hypusine biosynthetic process" EXACT [] synonym: "hypusine biosynthetic process from peptidyl-lysine" EXACT [] synonym: "hypusine formation" EXACT [] synonym: "hypusine formation from peptidyl-lysine" EXACT [] synonym: "hypusine synthesis" EXACT [] synonym: "hypusine synthesis from peptidyl-lysine" EXACT [] xref: Reactome:1253557 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1280496 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1299323 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1327075 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1353169 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1373348 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1393370 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1417867 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1450956 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1471337 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1496987 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1514374 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1521249 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1526965 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1532701 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:1536107 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:204626 "Hypusine synthesis from eIF5A-lysine" xref: RESID:AA0116 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046516 ! hypusine metabolic process [Term] id: GO:0008613 name: diuretic hormone activity namespace: molecular_function def: "The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894] is_a: GO:0005179 ! hormone activity [Term] id: GO:0008614 name: pyridoxine metabolic process namespace: biological_process alt_id: GO:0006773 def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [CHEBI:16709, GOC:curators] subset: gosubset_prok synonym: "pyridoxine metabolism" EXACT [] is_a: GO:0042816 ! vitamin B6 metabolic process [Term] id: GO:0008615 name: pyridoxine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai] subset: gosubset_prok synonym: "pyridoxine anabolism" EXACT [] synonym: "pyridoxine biosynthesis" EXACT [] synonym: "pyridoxine formation" EXACT [] synonym: "pyridoxine synthesis" EXACT [] xref: MetaCyc:PYRIDOXSYN-PWY is_a: GO:0008614 ! pyridoxine metabolic process is_a: GO:0042819 ! vitamin B6 biosynthetic process [Term] id: GO:0008616 name: queuosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "queuosine anabolism" EXACT [] synonym: "queuosine biosynthesis" EXACT [] synonym: "queuosine formation" EXACT [] synonym: "queuosine synthesis" EXACT [] is_a: GO:0006400 ! tRNA modification is_a: GO:0046116 ! queuosine metabolic process is_a: GO:0046118 ! 7-methylguanosine biosynthetic process [Term] id: GO:0008617 name: guanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "guanosine metabolism" EXACT [] is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0008618 name: 7-methylguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "7-methylguanosine metabolism" EXACT [] is_a: GO:0008617 ! guanosine metabolic process [Term] id: GO:0008619 name: RHEB small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47, PMID:12893813] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0001558 consider: GO:0051726 [Term] id: GO:0008622 name: epsilon DNA polymerase complex namespace: cellular_component def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046] synonym: "DNA polymerase epsilon complex" EXACT [CORUM:420] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000109 ! nucleotide-excision repair complex relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0008623 name: chromatin accessibility complex namespace: cellular_component alt_id: GO:0016588 def: "A multisubunit complex that uses ATP to increase the general accessibility of DNA in chromatin. Unlike other known chromatin remodeling complexes, CHRAC can also function during chromatin assembly; it uses ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing." [GOC:bf, PMID:9252192] synonym: "CHRAC" EXACT [] synonym: "ISW2 complex" NARROW [] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0008624 name: induction of apoptosis by extracellular signals namespace: biological_process def: "Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis." [GOC:ai] xref: Reactome:109607 "Extrinsic Pathway for Apoptosis" xref: Reactome:1229716 "FASL binds FAS Receptor" xref: Reactome:1252950 "FasL/ CD95L signaling" xref: Reactome:1252951 "Death Receptor Signalling" xref: Reactome:1252952 "Extrinsic Pathway for Apoptosis" xref: Reactome:1253486 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1253488 "Ceramide signalling" xref: Reactome:1279982 "Death Receptor Signalling" xref: Reactome:1279983 "Extrinsic Pathway for Apoptosis" xref: Reactome:1280423 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1280426 "Ceramide signalling" xref: Reactome:1298875 "Death Receptor Signalling" xref: Reactome:1298876 "Extrinsic Pathway for Apoptosis" xref: Reactome:1299257 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1299259 "Ceramide signalling" xref: Reactome:1303542 "FASL binds FAS Receptor" xref: Reactome:1326453 "FasL/ CD95L signaling" xref: Reactome:1326454 "Death Receptor Signalling" xref: Reactome:1326455 "Extrinsic Pathway for Apoptosis" xref: Reactome:1327002 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1327005 "Ceramide signalling" xref: Reactome:1331012 "FASL binds FAS Receptor" xref: Reactome:1352569 "FasL/ CD95L signaling" xref: Reactome:1352570 "Death Receptor Signalling" xref: Reactome:1352571 "Extrinsic Pathway for Apoptosis" xref: Reactome:1353096 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1353099 "Ceramide signalling" xref: Reactome:1355992 "FASL binds FAS Receptor" xref: Reactome:1372796 "FasL/ CD95L signaling" xref: Reactome:1372797 "Death Receptor Signalling" xref: Reactome:1372798 "Extrinsic Pathway for Apoptosis" xref: Reactome:1373285 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1373287 "Ceramide signalling" xref: Reactome:1376979 "FASL binds FAS Receptor" xref: Reactome:1392806 "FasL/ CD95L signaling" xref: Reactome:1392807 "Death Receptor Signalling" xref: Reactome:1392808 "Extrinsic Pathway for Apoptosis" xref: Reactome:1393300 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1393303 "Ceramide signalling" xref: Reactome:1417381 "Death Receptor Signalling" xref: Reactome:1417382 "Extrinsic Pathway for Apoptosis" xref: Reactome:1417798 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1417799 "Ceramide signalling" xref: Reactome:1423154 "FASL binds FAS Receptor" xref: Reactome:1450372 "FasL/ CD95L signaling" xref: Reactome:1450373 "Death Receptor Signalling" xref: Reactome:1450374 "Extrinsic Pathway for Apoptosis" xref: Reactome:1450897 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1450898 "Ceramide signalling" xref: Reactome:1471280 "Ceramide signalling" xref: Reactome:1471340 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1483250 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1483252 "Ceramide signalling" xref: Reactome:1496990 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1514377 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1526931 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1526933 "Ceramide signalling" xref: Reactome:1532667 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:1532669 "Ceramide signalling" xref: Reactome:193681 "Ceramide signalling" xref: Reactome:204998 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:73887 "Death Receptor Signalling" xref: Reactome:75157 "FasL/ CD95L signaling" xref: Reactome:75244 "FASL binds FAS Receptor" is_a: GO:0006917 ! induction of apoptosis [Term] id: GO:0008625 name: induction of apoptosis via death domain receptors namespace: biological_process def: "Any process that directly activates any of the steps required for cell death by apoptosis as a result of a death receptor binding to one of its physiological ligands." [GOC:mah] synonym: "induction of apoptosis via death receptors" EXACT [GOC:mah] is_a: GO:0008624 ! induction of apoptosis by extracellular signals [Term] id: GO:0008626 name: induction of apoptosis by granzyme namespace: biological_process def: "Any process induced by granzyme that directly activates any of the steps required for cell death by apoptosis. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells." [PMID:17158907] is_a: GO:0008624 ! induction of apoptosis by extracellular signals [Term] id: GO:0008627 name: induction of apoptosis by ionic changes namespace: biological_process def: "Any process induced by changes in intracellular ion homeostasis that directly activates any of the steps required for cell death by apoptosis." [PMID:11454444, PMID:16483738] is_a: GO:0008629 ! induction of apoptosis by intracellular signals [Term] id: GO:0008628 name: induction of apoptosis by hormones namespace: biological_process def: "Any process induced by hormones that directly activates any of the steps required for cell death by apoptosis." [GOC:bf] is_a: GO:0008624 ! induction of apoptosis by extracellular signals is_a: GO:0035081 ! induction of programmed cell death by hormones [Term] id: GO:0008629 name: induction of apoptosis by intracellular signals namespace: biological_process def: "Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis." [GOC:ai] xref: Reactome:109606 "Intrinsic Pathway for Apoptosis" xref: Reactome:1253220 "Intrinsic Pathway for Apoptosis" xref: Reactome:1280154 "Intrinsic Pathway for Apoptosis" xref: Reactome:1299029 "Intrinsic Pathway for Apoptosis" xref: Reactome:1326728 "Intrinsic Pathway for Apoptosis" xref: Reactome:1352837 "Intrinsic Pathway for Apoptosis" xref: Reactome:1373048 "Intrinsic Pathway for Apoptosis" xref: Reactome:1393063 "Intrinsic Pathway for Apoptosis" xref: Reactome:1417543 "Intrinsic Pathway for Apoptosis" xref: Reactome:1450637 "Intrinsic Pathway for Apoptosis" xref: Reactome:1536053 "Intrinsic Pathway for Apoptosis" is_a: GO:0006917 ! induction of apoptosis [Term] id: GO:0008630 name: DNA damage response, signal transduction resulting in induction of apoptosis namespace: biological_process def: "A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death)." [GOC:go_curators] is_a: GO:0008629 ! induction of apoptosis by intracellular signals is_a: GO:0042770 ! signal transduction in response to DNA damage [Term] id: GO:0008631 name: induction of apoptosis by oxidative stress namespace: biological_process def: "The activation, by oxidative stress, of any of the steps required for cell death by apoptosis." [GOC:ai] is_a: GO:0008629 ! induction of apoptosis by intracellular signals [Term] id: GO:0008633 name: activation of pro-apoptotic gene products namespace: biological_process def: "The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah] synonym: "induction of pro-apoptotic gene products" RELATED [] xref: Reactome:111446 "Activation of BIM and translocation to mitochondria" xref: Reactome:111447 "Activation of BAD and translocation to mitochondria" xref: Reactome:111448 "Activation of NOXA and translocation to mitochondria" xref: Reactome:111452 "Activation and oligomerization of BAK protein" xref: Reactome:114294 "Activation, translocation and oligomerization of BAX" xref: Reactome:114452 "Activation of BH3-only proteins" xref: Reactome:1231885 "Granzyme-B activates BID by cleavage" xref: Reactome:1231887 "tBID activates BAK protein" xref: Reactome:1231895 "Caspase-8 activates BID by cleavage" xref: Reactome:1253015 "Caspase-8 is formed from procaspase-8" xref: Reactome:1253219 "Activation and oligomerization of BAK protein" xref: Reactome:1253221 "Activation, translocation and oligomerization of BAX" xref: Reactome:1253248 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:1253249 "Activation of BAD and translocation to mitochondria" xref: Reactome:1253250 "Activation of BH3-only proteins" xref: Reactome:1253251 "Activation of BMF and translocation to mitochondria" xref: Reactome:1253252 "Activation of PUMA and translocation to mitochondria" xref: Reactome:1253253 "Activation of BIM and translocation to mitochondria" xref: Reactome:1259613 "Granzyme-B activates BID by cleavage" xref: Reactome:1259615 "tBID activates BAK protein" xref: Reactome:1259625 "Caspase-8 activates BID by cleavage" xref: Reactome:1280153 "Activation and oligomerization of BAK protein" xref: Reactome:1280155 "Activation, translocation and oligomerization of BAX" xref: Reactome:1280184 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:1280185 "Activation of BAD and translocation to mitochondria" xref: Reactome:1280186 "Activation of BH3-only proteins" xref: Reactome:1280187 "Activation of BMF and translocation to mitochondria" xref: Reactome:1280188 "Activation of PUMA and translocation to mitochondria" xref: Reactome:1280189 "Activation of BIM and translocation to mitochondria" xref: Reactome:1280190 "Caspase-8 is formed from procaspase-8" xref: Reactome:1285006 "Granzyme-B activates BID by cleavage" xref: Reactome:1285008 "tBID activates BAK protein" xref: Reactome:1285018 "Caspase-8 activates BID by cleavage" xref: Reactome:1299028 "Activation and oligomerization of BAK protein" xref: Reactome:1299030 "Activation, translocation and oligomerization of BAX" xref: Reactome:1299057 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:1299058 "Activation of BAD and translocation to mitochondria" xref: Reactome:1299059 "Activation of BH3-only proteins" xref: Reactome:1299060 "Activation of BIM and translocation to mitochondria" xref: Reactome:1299061 "Caspase-8 is formed from procaspase-8" xref: Reactome:1305577 "Granzyme-B activates BID by cleavage" xref: Reactome:1305579 "tBID activates BAK protein" xref: Reactome:1305587 "Caspase-8 activates BID by cleavage" xref: Reactome:1326519 "Caspase-8 is formed from procaspase-8" xref: Reactome:1326730 "Activation and oligomerization of BAK protein" xref: Reactome:1326731 "Activation, translocation and oligomerization of BAX" xref: Reactome:1326761 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:1326762 "Activation of BAD and translocation to mitochondria" xref: Reactome:1326763 "Activation of BH3-only proteins" xref: Reactome:1326764 "Activation of BMF and translocation to mitochondria" xref: Reactome:1326765 "Activation of BIM and translocation to mitochondria" xref: Reactome:1333143 "Granzyme-B activates BID by cleavage" xref: Reactome:1333145 "tBID activates BAK protein" xref: Reactome:1333153 "Caspase-8 activates BID by cleavage" xref: Reactome:1352626 "Caspase-8 is formed from procaspase-8" xref: Reactome:1352836 "Activation and oligomerization of BAK protein" xref: Reactome:1352838 "Activation, translocation and oligomerization of BAX" xref: Reactome:1352865 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:1352866 "Activation of BAD and translocation to mitochondria" xref: Reactome:1352867 "Activation of BH3-only proteins" xref: Reactome:1352868 "Activation of BMF and translocation to mitochondria" xref: Reactome:1352869 "Activation of BIM and translocation to mitochondria" xref: Reactome:1357574 "tBID activates BAK protein" xref: Reactome:1357577 "Caspase-8 activates BID by cleavage" xref: Reactome:1372854 "Caspase-8 is formed from procaspase-8" xref: Reactome:1373050 "Activation and oligomerization of BAK protein" xref: Reactome:1373073 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:1373074 "Activation of BMF and translocation to mitochondria" xref: Reactome:1373075 "Activation of BH3-only proteins" xref: Reactome:1378579 "tBID activates BAK protein" xref: Reactome:1378582 "Caspase-8 activates BID by cleavage" xref: Reactome:1392867 "Caspase-8 is formed from procaspase-8" xref: Reactome:1393065 "Activation and oligomerization of BAK protein" xref: Reactome:1393066 "Activation, translocation and oligomerization of BAX" xref: Reactome:1393089 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:1393090 "Activation of BMF and translocation to mitochondria" xref: Reactome:1393091 "Activation of BH3-only proteins" xref: Reactome:139893 "Granzyme-B activates BID by cleavage" xref: Reactome:139895 "tBID activates BAK protein" xref: Reactome:139898 "Caspase-8 activates BID by cleavage" xref: Reactome:139910 "Activation of BMF and translocation to mitochondria" xref: Reactome:1399130 "tBID activates BAK protein" xref: Reactome:139915 "Activation of PUMA and translocation to mitochondria" xref: Reactome:140534 "Caspase-8 is formed from procaspase-8" xref: Reactome:1417545 "Activation and oligomerization of BAK protein" xref: Reactome:1417546 "Activation, translocation and oligomerization of BAX" xref: Reactome:1417574 "Activation of BMF and translocation to mitochondria" xref: Reactome:1417575 "Activation of BH3-only proteins" xref: Reactome:1417576 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:1450434 "Caspase-8 is formed from procaspase-8" xref: Reactome:1450639 "Activation, translocation and oligomerization of BAX" xref: Reactome:1450666 "Activation of BAD and translocation to mitochondria" xref: Reactome:1450667 "Activation of BH3-only proteins" xref: Reactome:75108 "Activation, myristolyation of BID and translocation to mitochondria" is_a: GO:0043065 ! positive regulation of apoptosis relationship: part_of GO:0006915 ! apoptosis [Term] id: GO:0008634 name: negative regulation of survival gene product expression namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of survival gene product activity" BROAD [] synonym: "down-regulation of survival gene product activity" BROAD [] synonym: "downregulation of survival gene product activity" BROAD [] synonym: "inhibition of survival gene product activity" NARROW [] synonym: "negative regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] synonym: "negative regulation of survival gene products" BROAD [] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:0045884 ! regulation of survival gene product expression [Term] id: GO:0008635 name: activation of caspase activity by cytochrome c namespace: biological_process def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c." [GOC:dph, GOC:jl, GOC:tb, PMID:14744432, Wikipedia:Caspase] synonym: "caspase activation via cytochrome c" EXACT [GOC:dph, GOC:tb] xref: Reactome:111459 "Activation of caspases through apoptosome-mediated cleavage" xref: Reactome:1326725 "Activation of caspases through apoptosome-mediated cleavage" xref: Reactome:1373045 "Activation of caspases through apoptosome-mediated cleavage" xref: Reactome:1393060 "Activation of caspases through apoptosome-mediated cleavage" xref: Reactome:1417540 "Activation of caspases through apoptosome-mediated cleavage" xref: Reactome:1450634 "Activation of caspases through apoptosome-mediated cleavage" is_a: GO:0006919 ! activation of caspase activity [Term] id: GO:0008636 name: activation of caspase activity by protein phosphorylation namespace: biological_process def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group." [GOC:dph, GOC:jl, GOC:tb, PMID:14744432, Wikipedia:Caspase] synonym: "activation of caspase activity by protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "caspase activation via phosphorylation" EXACT [GOC:dph, GOC:tb] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0006919 ! activation of caspase activity [Term] id: GO:0008637 name: apoptotic mitochondrial changes namespace: biological_process def: "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah] is_a: GO:0007005 ! mitochondrion organization relationship: part_of GO:0006915 ! apoptosis [Term] id: GO:0008638 name: protein tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation." [GOC:jl] comment: This term was made obsolete because it represents a biological process and a molecular function. is_obsolete: true consider: GO:0005515 consider: GO:0006464 consider: GO:0031386 [Term] id: GO:0008641 name: small protein activating enzyme activity namespace: molecular_function alt_id: GO:0008642 def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "ubiquitin-like activating enzyme activity" NARROW [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0008643 name: carbohydrate transport namespace: biological_process alt_id: GO:0006861 alt_id: GO:0008644 def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "sugar transport" NARROW [] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0008645 name: hexose transport namespace: biological_process def: "The directed movement of hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:ai] subset: gosubset_prok xref: Reactome:1252924 "Hexose transport" xref: Reactome:1279858 "Hexose transport" xref: Reactome:1298772 "Hexose transport" xref: Reactome:1326427 "Hexose transport" xref: Reactome:1352543 "Hexose transport" xref: Reactome:1372770 "Hexose transport" xref: Reactome:1392780 "Hexose transport" xref: Reactome:1417257 "Hexose transport" xref: Reactome:1450346 "Hexose transport" xref: Reactome:1470887 "Hexose transport" xref: Reactome:1482919 "Hexose transport" xref: Reactome:1496715 "Hexose transport" xref: Reactome:1514106 "Hexose transport" xref: Reactome:1526676 "Hexose transport" xref: Reactome:1532403 "Hexose transport" xref: Reactome:1535962 "Hexose transport" xref: Reactome:1538044 "Hexose transport" xref: Reactome:189200 "Hexose transport" is_a: GO:0015749 ! monosaccharide transport [Term] id: GO:0008646 name: high-affinity hexose transport namespace: biological_process def: "The directed, high-affinity movement of a hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] is_a: GO:0035428 ! hexose transmembrane transport [Term] id: GO:0008647 name: low-affinity hexose transport namespace: biological_process def: "The directed, low-affinity movement of a hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] is_a: GO:0035428 ! hexose transmembrane transport [Term] id: GO:0008648 name: tachykinin namespace: molecular_function def: "OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0005102 consider: GO:0045909 consider: GO:0045987 consider: GO:0046878 [Term] id: GO:0008649 name: rRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008650 name: rRNA (uridine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity [Term] id: GO:0008651 name: actin polymerizing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0030041 replaced_by: GO:0042802 [Term] id: GO:0008652 name: cellular amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amino acid biosynthetic process" EXACT [GOC:curators] synonym: "cellular amino acid anabolism" EXACT [] synonym: "cellular amino acid biosynthesis" EXACT [] synonym: "cellular amino acid formation" EXACT [] synonym: "cellular amino acid synthesis" EXACT [] xref: Reactome:1252931 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1279865 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1298779 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1326434 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1352550 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1372779 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1392789 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1417264 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1450353 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1470892 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1482924 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1496720 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1514111 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1520931 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1526681 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1532410 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1535972 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1537977 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:1539230 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:70614 "Amino acid synthesis and interconversion (transamination)" xref: Wikipedia:Amino_acid_synthesis is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0009309 ! amine biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0008653 name: lipopolysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipopolysaccharide metabolism" EXACT [] synonym: "LPS metabolic process" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0008654 name: phospholipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phospholipid anabolism" EXACT [] synonym: "phospholipid biosynthesis" EXACT [] synonym: "phospholipid formation" EXACT [] synonym: "phospholipid synthesis" EXACT [] xref: MetaCyc:LIPASYN-PWY xref: MetaCyc:PHOSLIPSYN-PWY xref: MetaCyc:PHOSLIPSYN2-PWY is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0008655 name: pyrimidine-containing compound salvage namespace: biological_process def: "Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [CHEBI:39447, GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "pyrimidine salvage" RELATED [GOC:curators] is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0008656 name: caspase activator activity namespace: molecular_function def: "Increases the rate of proteolysis catalyzed by a caspase." [GOC:mah] xref: Reactome:25527 "caspase activator activity" is_a: GO:0016505 ! apoptotic protease activator activity is_a: GO:0043028 ! caspase regulator activity [Term] id: GO:0008657 name: DNA topoisomerase (ATP-hydrolyzing) inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] synonym: "DNA gyrase inhibitor activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0008658 name: penicillin binding namespace: molecular_function def: "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] subset: gosubset_prok is_a: GO:0008144 ! drug binding is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0008659 name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.-, GOC:ai] synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT [] xref: EC:4.2.1.- is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008660 name: 1-aminocyclopropane-1-carboxylate deaminase activity namespace: molecular_function alt_id: GO:0018806 def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanate + NH(4)(+)." [EC:3.5.99.7, RHEA:16936] comment: Note that this function was formerly EC:4.1.99.4. subset: gosubset_prok synonym: "1-aminocyclopropane carboxylic acid deaminase activity" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" EXACT [EC:3.5.99.7] synonym: "ACC deaminase activity" EXACT [EC:3.5.99.7] xref: EC:3.5.99.7 xref: KEGG:R00997 xref: MetaCyc:4.1.99.4-RXN xref: RHEA:16936 xref: UM-BBD_reactionID:r0357 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008661 name: 1-deoxy-D-xylulose-5-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2)." [EC:2.2.1.7, RHEA:12608] subset: gosubset_prok synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [] synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT [] synonym: "DOXP synthase activity" EXACT [] synonym: "DXP-synthase activity" EXACT [] synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.7] xref: EC:2.2.1.7 xref: KEGG:R05636 xref: MetaCyc:DXS-RXN xref: RHEA:12608 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0008662 name: 1-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56] subset: gosubset_prok synonym: "1-phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.56] synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.56] synonym: "D-fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose 1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56] xref: EC:2.7.1.56 xref: MetaCyc:1PFRUCTPHOSN-RXN is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0008663 name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16] subset: gosubset_prok synonym: "2',3 '-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16] synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2':3'-cyclic phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.4.16] synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16] xref: EC:3.1.4.16 xref: MetaCyc:CYCPHOSDIESTER-RXN is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0008664 name: 2'-5'-RNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another." [GOC:mah, PMID:8940112] subset: gosubset_prok synonym: "2'-5' RNA ligase activity" EXACT [] xref: EC:6.5.1.- is_a: GO:0008452 ! RNA ligase activity [Term] id: GO:0008665 name: 2'-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group from one compound to the 2' position of another." [GOC:jl, GOC:mah] subset: gosubset_prok xref: MetaCyc:2.7.1.160-RXN is_a: GO:0016740 ! transferase activity [Term] id: GO:0008666 name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H(2)O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA." [EC:2.3.1.117, RHEA:17328] subset: gosubset_prok synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinylase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydropicolinate succinylase activity" EXACT [EC:2.3.1.117] synonym: "THDP N-succinyltransferase activity" EXACT [PMID:19394346] xref: EC:2.3.1.117 xref: KEGG:R04365 xref: MetaCyc:TETHYDPICSUCC-RXN xref: RHEA:17328 is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0008667 name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH." [EC:1.3.1.28, RHEA:23827] subset: gosubset_prok synonym: "2,3-DHB dehydrogenase activity" EXACT [EC:1.3.1.28] synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.28] xref: EC:1.3.1.28 xref: KEGG:R01505 xref: MetaCyc:DHBDEHYD-RXN xref: RHEA:23827 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008668 name: (2,3-dihydroxybenzoyl)adenylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate." [EC:2.7.7.58, RHEA:20232] subset: gosubset_prok synonym: "2,3-dihydroxybenzoate-AMP ligase activity" EXACT [] synonym: "ATP:2,3-dihydroxybenzoate adenylyltransferase activity" EXACT [EC:2.7.7.58] xref: EC:2.7.7.58 xref: KEGG:R01504 xref: MetaCyc:DHBAMPLIG-RXN xref: RHEA:20232 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008670 name: 2,4-dienoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34] subset: gosubset_prok synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH) activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH2)" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34] synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34] xref: EC:1.3.1.34 xref: MetaCyc:DIENOYLCOAREDUCT-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008671 name: 2-dehydro-3-deoxygalactonokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H(+)." [EC:2.7.1.58, RHEA:16528] subset: gosubset_prok synonym: "2-keto-3-deoxy-galactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-oxo-3-deoxygalactonate kinase activity" EXACT [EC:2.7.1.58] synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" EXACT [EC:2.7.1.58] xref: EC:2.7.1.58 xref: KEGG:R03387 xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN xref: RHEA:16528 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008672 name: 2-dehydro-3-deoxyglucarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20] subset: gosubset_prok synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.20] synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" EXACT [EC:4.1.2.20] synonym: "2-keto-3-deoxyglucarate aldolase activity" EXACT [EC:4.1.2.20] synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" EXACT [EC:4.1.2.20] xref: EC:4.1.2.20 xref: MetaCyc:KDGALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008673 name: 2-dehydro-3-deoxygluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.45, RHEA:14800] subset: gosubset_prok synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase activity" EXACT [EC:2.7.1.45] synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.45] synonym: "KDG kinase activity" EXACT [EC:2.7.1.45] synonym: "ketodeoxygluconokinase activity" EXACT [EC:2.7.1.45] xref: EC:2.7.1.45 xref: KEGG:R01541 xref: MetaCyc:DEOXYGLUCONOKIN-RXN xref: RHEA:14800 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008674 name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate." [EC:4.1.2.21, RHEA:24467] subset: gosubset_prok synonym: "(KDPGal)aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" EXACT [EC:4.1.2.21] xref: EC:4.1.2.21 xref: KEGG:R01064 xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN xref: RHEA:24467 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008675 name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14] subset: gosubset_prok synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.14] synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG-aldolase activity" EXACT [EC:4.1.2.14] synonym: "ODPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" EXACT [EC:4.1.2.14] xref: EC:4.1.2.14 xref: MetaCyc:KDPGALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008676 name: 3-deoxy-8-phosphooctulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate." [EC:2.5.1.55, RHEA:14056] comment: Note that this function was formerly EC:4.1.2.16. subset: gosubset_prok synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-P synthase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDOP synthase activity" EXACT [EC:2.5.1.55] synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.55] xref: EC:2.5.1.55 xref: KEGG:R03254 xref: MetaCyc:KDO-8PSYNTH-RXN xref: RHEA:14056 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008677 name: 2-dehydropantoate 2-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH." [EC:1.1.1.169, RHEA:16236] subset: gosubset_prok synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "2-oxopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "KPA reductase activity" EXACT [EC:1.1.1.169] xref: EC:1.1.1.169 xref: KEGG:R02472 xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN xref: RHEA:16236 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008678 name: 2-deoxy-D-gluconate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125] subset: gosubset_prok synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.125] synonym: "2-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.125] synonym: "2-keto-3-deoxygluconate oxidoreductase activity" EXACT [EC:1.1.1.125] xref: EC:1.1.1.125 xref: MetaCyc:KDUD-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008679 name: 2-hydroxy-3-oxopropionate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60] subset: gosubset_prok synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.60] synonym: "tartronate semialdehyde reductase activity" EXACT [EC:1.1.1.60] xref: EC:1.1.1.60 xref: MetaCyc:TSA-REDUCT-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008681 name: 2-octaprenyl-6-methoxyphenol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O." [MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN] subset: gosubset_prok xref: EC:1.14.14.- xref: MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008682 name: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone." [MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN] xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0008683 name: 2-oxoglutarate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + H(+) = CO(2) + succinate semialdehyde." [EC:4.1.1.71, RHEA:10527] subset: gosubset_prok synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" EXACT [EC:4.1.1.71] synonym: "2-oxoglutarate carboxy-lyase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutaric decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "pre-2-oxoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] xref: EC:4.1.1.71 xref: KEGG:R00272 xref: MetaCyc:RXN-7774 xref: RHEA:10527 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008684 name: 2-oxopent-4-enoate hydratase activity namespace: molecular_function alt_id: GO:0018821 def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80] subset: gosubset_prok synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" EXACT [EC:4.2.1.80] synonym: "2-keto-4-pentenoate hydratase activity" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" EXACT [EC:4.2.1.80] synonym: "OEH activity" EXACT [EC:4.2.1.80] xref: EC:4.2.1.80 xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN xref: UM-BBD_enzymeID:e0078 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008685 name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP." [EC:4.6.1.12, RHEA:23867] subset: gosubset_prok synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" EXACT [EC:4.6.1.12] synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" EXACT [EC:4.6.1.12] synonym: "MECDP-synthase activity" EXACT [EC:4.6.1.12] synonym: "MECP synthase activity" EXACT [] xref: EC:4.6.1.12 xref: KEGG:R05637 xref: MetaCyc:RXN0-302 xref: RHEA:23867 is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0008686 name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)." [EC:4.1.99.12, RHEA:18460] subset: gosubset_prok xref: EC:4.1.99.12 xref: KEGG:R07281 xref: MetaCyc:DIOHBUTANONEPSYN-RXN xref: RHEA:18460 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0008687 name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O(2) = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H(+)." [EC:1.13.11.15, RHEA:15636] subset: gosubset_prok synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.15] synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "homoprotocatechuate 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "HPC dioxygenase activity" EXACT [EC:1.13.11.15] xref: EC:1.13.11.15 xref: KEGG:R03303 xref: MetaCyc:1.13.11.15-RXN xref: RHEA:15636 xref: UM-BBD_reactionID:r0364 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0008688 name: 3-(3-hydroxyphenyl)propionate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O." [MetaCyc:MHPHYDROXY-RXN] xref: EC:1.14.13.- xref: KEGG:R06786 xref: MetaCyc:MHPHYDROXY-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008689 name: 3-demethylubiquinone-9 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [EC:2.1.1.64] subset: gosubset_prok synonym: "5-demethylubiquinone-9 methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "OMHMB-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity" EXACT [EC:2.1.1.64] xref: EC:2.1.1.64 xref: MetaCyc:DHHB-METHYLTRANSFER-RXN is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008690 name: 3-deoxy-manno-octulosonate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38] subset: gosubset_prok synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-KDO synthetase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT [] synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] xref: EC:2.7.7.38 xref: MetaCyc:CPM-KDOSYNTH-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0008691 name: 3-hydroxybutyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157] subset: gosubset_prok synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "BHBD activity" EXACT [EC:1.1.1.157] synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.157] synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] xref: EC:1.1.1.157 xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008692 name: 3-hydroxybutyryl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3] subset: gosubset_prok synonym: "3-hydroxyacyl-CoA epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutyryl coenzyme A epimerase activity" EXACT [EC:5.1.2.3] xref: EC:5.1.2.3 xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0008693 name: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.60] subset: gosubset_prok synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxyacyl-ACP dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoate dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoyl thioester dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoyl thiol ester dehydrase activity" EXACT [EC:4.2.1.60] synonym: "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.60] synonym: "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "FabA" RELATED [EC:4.2.1.60] synonym: "HDDase activity" EXACT [EC:4.2.1.60] xref: EC:4.2.1.60 is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0008694 name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity namespace: molecular_function alt_id: GO:0019167 def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN] subset: gosubset_prok synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT [] synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "PPHB decarboxylase activity" EXACT [] synonym: "UbiD" RELATED [] synonym: "UbiX" RELATED [] xref: EC:4.1.1.- xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008695 name: 3-phenylpropionate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307] synonym: "3-phenylpropanoate dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" EXACT [EC:1.14.12.19] synonym: "Hca dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19] xref: EC:1.14.12.19 xref: MetaCyc:HCAMULTI-RXN xref: UM-BBD_enzymeID:e0307 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0008696 name: 4-amino-4-deoxychorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate." [EC:4.1.3.38, RHEA:16204] comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. subset: gosubset_prok synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" EXACT [EC:4.1.3.38] synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" EXACT [EC:4.1.3.38] synonym: "ADC lyase activity" EXACT [EC:4.1.3.38] synonym: "aminodeoxychorismate lyase activity" EXACT [] synonym: "enzyme X activity" RELATED [EC:4.1.3.38] synonym: "p-aminobenzoate synthetase" RELATED [] synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] synonym: "para-aminobenzoic acid synthase" RELATED [] xref: EC:4.1.3.38 xref: KEGG:R05553 xref: MetaCyc:ADCLY-RXN xref: RHEA:16204 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008697 name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17, RHEA:23899] subset: gosubset_prok synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.17] synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" EXACT [EC:5.3.1.17] synonym: "5-keto-4-deoxyuronate isomerase activity" EXACT [EC:5.3.1.17] xref: EC:5.3.1.17 xref: KEGG:R04383 xref: MetaCyc:5.3.1.17-RXN xref: RHEA:23899 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008700 name: 4-hydroxy-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.16] subset: gosubset_prok synonym: "2-keto-4-hydroxybutyrate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" EXACT [EC:4.1.3.16] synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "KHG-aldolase activity" EXACT [EC:4.1.3.16] xref: EC:4.1.3.16 xref: MetaCyc:4OH2OXOGLUTARALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008701 name: 4-hydroxy-2-oxovalerate aldolase activity namespace: molecular_function alt_id: GO:0018804 def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate." [EC:4.1.3.39, RHEA:22627] synonym: "4-hydroxy-2-ketovalerate aldolase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "DmpG" RELATED [EC:4.1.3.39] synonym: "HOA" RELATED [EC:4.1.3.39] xref: EC:4.1.3.39 xref: KEGG:R00750 xref: MetaCyc:MHPELY-RXN xref: RHEA:22627 xref: UM-BBD_enzymeID:e0077 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008703 name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH." [EC:1.1.1.193, RHEA:17848] subset: gosubset_prok synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT [] synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" EXACT [EC:1.1.1.193] synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" EXACT [EC:1.1.1.193] xref: EC:1.1.1.193 xref: KEGG:R03458 xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN xref: RHEA:17848 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008704 name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity namespace: molecular_function alt_id: GO:0018843 def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10] subset: gosubset_prok synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED [] synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT [] synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" EXACT [EC:5.3.3.10] synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" EXACT [EC:5.3.3.10] synonym: "CHM isomerase activity" EXACT [EC:5.3.3.10] synonym: "HHDD isomerase activity" EXACT [] synonym: "hpaG-1" RELATED [] synonym: "hpaG1" RELATED [] xref: EC:5.3.3.10 xref: MetaCyc:5.3.3.10-RXN xref: UM-BBD_reactionID:r0366 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0008705 name: methionine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." [EC:2.1.1.13, RHEA:11175] subset: gosubset_prok synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT [] synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "cobalamin-dependent methionine synthase activity" EXACT [EC:2.1.1.13] synonym: "MetH" RELATED [EC:2.1.1.13] synonym: "methionine synthase (cobalamin-dependent) activity" EXACT [EC:2.1.1.13] synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamic methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] xref: EC:2.1.1.13 xref: KEGG:R00946 xref: MetaCyc:HOMOCYSMETB12-RXN xref: Reactome:25894 "methionine synthase activity" xref: RHEA:11175 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0008706 name: 6-phospho-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86] subset: gosubset_prok synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" EXACT [EC:3.2.1.86] synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86] synonym: "phospho-beta-glucosidase activity" EXACT [EC:3.2.1.86] synonym: "phosphocellobiase activity" EXACT [EC:3.2.1.86] xref: EC:3.2.1.86 xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0008707 name: 4-phytase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26] subset: gosubset_prok synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26] synonym: "6-phytase activity" EXACT [] synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.26] synonym: "phytase activity" BROAD [EC:3.1.3.26] synonym: "phytate 6-phosphatase activity" EXACT [EC:3.1.3.26] xref: EC:3.1.3.26 xref: MetaCyc:6-PHYT-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008709 name: cholate 7-alpha-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH." [EC:1.1.1.159, RHEA:19412] subset: gosubset_prok synonym: "7-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159] synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159] synonym: "7alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" BROAD [EC:1.1.1.159] xref: EC:1.1.1.159 xref: KEGG:R02792 xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN xref: RHEA:19412 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008710 name: 8-amino-7-oxononanoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H(+) + pimelyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA." [EC:2.3.1.47, RHEA:20715] subset: gosubset_prok synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" EXACT [EC:2.3.1.47] synonym: "7-KAP synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-amino-pelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic synthetase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-ketopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-oxopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "AONS activity" EXACT [EC:2.3.1.47] xref: EC:2.3.1.47 xref: KEGG:R03210 xref: MetaCyc:7KAPSYN-RXN xref: RHEA:20715 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008711 name: ADP-L-glycero-D-manno-heptose synthase activity namespace: molecular_function def: "OBSOLETE." [GOC:curators] comment: This term was made obsolete because it represents a bifunctional gene product (e.g. E. coli RfaE). is_obsolete: true consider: GO:0033785 consider: GO:0033786 [Term] id: GO:0008712 name: ADP-glyceromanno-heptose 6-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20, RHEA:17580] subset: gosubset_prok synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] synonym: "ADPglyceromanno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] xref: EC:5.1.3.20 xref: KEGG:R05176 xref: MetaCyc:5.1.3.20-RXN xref: RHEA:17580 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008713 name: ADP-heptose-lipopolysaccharide heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+." [MetaCyc:RXN0-5061] subset: gosubset_prok synonym: "ADP-heptose:LPS heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY] xref: MetaCyc:RXN0-5061 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity [Term] id: GO:0008714 name: AMP nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H(2)O = D-ribose 5-phosphate + adenine." [EC:3.2.2.4, RHEA:20132] subset: gosubset_prok synonym: "adenosine monophosphate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "adenylate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "AMP phosphoribohydrolase activity" EXACT [EC:3.2.2.4] xref: EC:3.2.2.4 xref: KEGG:R00182 xref: MetaCyc:AMP-NUCLEOSID-RXN xref: RHEA:20132 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008715 name: CDP-diacylglycerol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + H(2)O = a phosphatidate + CMP + 2 H(+)." [EC:3.6.1.26, RHEA:15224] subset: gosubset_prok synonym: "CDP diacylglycerol hydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT [] synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" EXACT [EC:3.6.1.26] xref: EC:3.6.1.26 xref: KEGG:R01797 xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN xref: RHEA:15224 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008716 name: D-alanine-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H(+) + phosphate." [EC:6.3.2.4, RHEA:11227] subset: gosubset_prok synonym: "alanine:alanine ligase (ADP-forming) activity" EXACT [EC:6.3.2.4] synonym: "alanylalanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-Ala-D-Ala synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanine:D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.4] synonym: "D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanylalanine synthetase activity" EXACT [EC:6.3.2.4] xref: EC:6.3.2.4 xref: KEGG:R01150 xref: MetaCyc:DALADALALIG-RXN xref: RHEA:11227 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008717 name: D-alanyl-D-alanine endopeptidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "penicillin-binding protein 7" NARROW [] synonym: "penicillin-binding protein 8" NARROW [] xref: EC:3.4.99.- is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0008718 name: D-amino-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [EC:1.4.99.1] subset: gosubset_prok synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] xref: EC:1.4.99.1 xref: MetaCyc:DAADEHYDROG-RXN is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0008719 name: dihydroneopterin triphosphate 2'-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN] subset: gosubset_prok synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT [] xref: EC:5.-.-.- xref: MetaCyc:H2NTPEPIM-RXN is_a: GO:0016853 ! isomerase activity [Term] id: GO:0008720 name: D-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate." [EC:1.1.1.28, RHEA:16372] subset: gosubset_prok synonym: "D-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.28] synonym: "D-lactic dehydrogenase activity" EXACT [EC:1.1.1.28] xref: EC:1.1.1.28 xref: KEGG:R00704 xref: MetaCyc:DLACTDEHYDROGNAD-RXN xref: RHEA:16372 is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008721 name: D-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18] comment: Note that this function was formerly EC:4.3.1.14. subset: gosubset_prok synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18] synonym: "D-hydroxyaminoacid dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.18] synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18] xref: EC:4.3.1.18 xref: MetaCyc:DSERDEAM-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008724 name: DNA topoisomerase IV activity namespace: molecular_function def: "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo." [EC:5.99.1.-, PMID:11274059] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003918 [Term] id: GO:0008725 name: DNA-3-methyladenine glycosylase I activity namespace: molecular_function def: "Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] subset: gosubset_prok synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20] synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20] synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20] synonym: "DNA-3-methyladenine glycosidase I activity" EXACT [EC:3.2.2.20] xref: EC:3.2.2.20 xref: MetaCyc:3.2.2.20-RXN is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity [Term] id: GO:0008726 name: alkanesulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN." [MetaCyc:RXN0-280] subset: gosubset_prok synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" EXACT [EC:1.14.14.5] synonym: "alkanesulphonate monooxygenase activity" EXACT [] synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT [] synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "SsuD" RELATED [EC:1.14.14.5] synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5] xref: EC:1.14.14.5 xref: MetaCyc:RXN0-280 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008727 name: GDP-mannose mannosyl hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+." [MetaCyc:GDPMANMANHYDRO-RXN] xref: MetaCyc:GDPMANMANHYDRO-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0008728 name: GTP diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5] subset: gosubset_prok synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5] synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5] synonym: "ATP-GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "ATP:GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "GPSI" RELATED [EC:2.7.6.5] synonym: "GPSII" RELATED [EC:2.7.6.5] synonym: "GTP pyrophosphokinase activity" EXACT [] synonym: "guanosine 3',5'-polyphosphate synthase activity" EXACT [EC:2.7.6.5] synonym: "guanosine 5',3'-polyphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "guanosine pentaphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "ppGpp synthetase I activity" EXACT [EC:2.7.6.5] synonym: "stringent factor activity" RELATED [EC:2.7.6.5] xref: EC:2.7.6.5 xref: MetaCyc:GTPPYPHOSKIN-RXN is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0008730 name: L(+)-tartrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate." [EC:4.2.1.32, RHEA:15416] subset: gosubset_prok synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.32] synonym: "(R,R)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.32] synonym: "L-(+)-tartaric acid dehydratase activity" EXACT [EC:4.2.1.32] synonym: "L-tartrate dehydratase activity" EXACT [EC:4.2.1.32] synonym: "tartaric acid dehydrase activity" EXACT [EC:4.2.1.32] synonym: "tartrate dehydratase activity" EXACT [EC:4.2.1.32] xref: EC:4.2.1.32 xref: KEGG:R00339 xref: MetaCyc:LTARTDEHYDRA-RXN xref: RHEA:15416 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008732 name: L-allo-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [MetaCyc:LTAA-RXN, PMID:9228760] subset: gosubset_prok synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT [] synonym: "LtaA" RELATED [] xref: EC:4.1.2.- xref: MetaCyc:LTAA-RXN is_a: GO:0004793 ! threonine aldolase activity [Term] id: GO:0008733 name: L-arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4, RHEA:14824] subset: gosubset_prok synonym: "L-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.4] synonym: "L-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.4] xref: EC:5.3.1.4 xref: KEGG:R01761 xref: MetaCyc:ARABISOM-RXN xref: RHEA:14824 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008734 name: L-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.16] subset: gosubset_prok synonym: "L-aspartate:oxygen oxidoreductase" EXACT [EC:1.4.3.16] xref: EC:1.4.3.16 xref: MetaCyc:L-ASPARTATE-OXID-RXN xref: MetaCyc:RXN-9772 is_a: GO:0015922 ! aspartate oxidase activity [Term] id: GO:0008735 name: carnitine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-carnitine = crotono-betaine + H(2)O." [EC:4.2.1.89, RHEA:14580] subset: gosubset_prok synonym: "L-carnitine dehydratase activity" EXACT [] synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED [EC:4.2.1.89] synonym: "L-carnitine hydro-lyase activity" EXACT [EC:4.2.1.89] xref: EC:4.2.1.89 xref: KEGG:R01925 xref: MetaCyc:CARNDEHYDRA-RXN xref: RHEA:14580 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008736 name: L-fucose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-fucose = L-fuculose." [EC:5.3.1.25] subset: gosubset_prok synonym: "L-fucose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.25] synonym: "L-fucose ketol-isomerase activity" EXACT [EC:5.3.1.25] xref: EC:5.3.1.25 xref: MetaCyc:FUCISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008737 name: L-fuculokinase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.51, RHEA:12379] subset: gosubset_prok synonym: "ATP:L-fuculose 1-phosphotransferase activity" EXACT [EC:2.7.1.51] synonym: "L-fuculokinase (phosphorylating)" EXACT [EC:2.7.1.51] synonym: "L-fuculose kinase activity" EXACT [EC:2.7.1.51] xref: EC:2.7.1.51 xref: KEGG:R03241 xref: MetaCyc:FUCULOKIN-RXN xref: RHEA:12379 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008738 name: L-fuculose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate." [EC:4.1.2.17, RHEA:12936] subset: gosubset_prok synonym: "fuculose aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose 1-phosphate aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.17] xref: EC:4.1.2.17 xref: KEGG:R02262 xref: MetaCyc:FUCPALDOL-RXN xref: RHEA:12936 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008740 name: L-rhamnose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [EC:5.3.1.14, RHEA:23163] subset: gosubset_prok synonym: "L-rhamnose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.14] synonym: "L-rhamnose ketol-isomerase activity" EXACT [EC:5.3.1.14] synonym: "rhamnose isomerase activity" EXACT [EC:5.3.1.14] xref: EC:5.3.1.14 xref: KEGG:R02437 xref: MetaCyc:RHAMNISOM-RXN xref: RHEA:23163 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008741 name: ribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16] subset: gosubset_prok synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.16] synonym: "L-ribulokinase activity" EXACT [] synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16] xref: EC:2.7.1.16 xref: MetaCyc:RIBULOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008742 name: L-ribulose-phosphate 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.4, RHEA:22371] subset: gosubset_prok synonym: "AraD" RELATED [EC:5.1.3.4] synonym: "L-ribulose 5-phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4] synonym: "L-Ru5P" RELATED [EC:5.1.3.4] synonym: "L-ru5P activity" EXACT [EC:5.1.3.4] synonym: "phosphoribulose isomerase activity" EXACT [EC:5.1.3.4] synonym: "ribulose phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] xref: EC:5.1.3.4 xref: KEGG:R05850 xref: MetaCyc:RIBULPEPIM-RXN xref: RHEA:22371 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008743 name: L-threonine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine + NAD(+) = aminoacetone + CO(2) + NADH." [EC:1.1.1.103, RHEA:25657] subset: gosubset_prok synonym: "L-threonine dehydrogenase activity" EXACT [EC:1.1.1.103] synonym: "L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.103] synonym: "threonine 3-dehydrogenase activity" BROAD [] synonym: "threonine dehydrogenase activity" EXACT [EC:1.1.1.103] xref: EC:1.1.1.103 xref: KEGG:R01465 xref: MetaCyc:THREODEHYD-RXN xref: RHEA:25657 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008744 name: L-xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53] subset: gosubset_prok synonym: "ATP:L-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.53] synonym: "L-xylulokinase (phosphorylating)" EXACT [EC:2.7.1.53] synonym: "L-xylulose kinase activity" EXACT [EC:2.7.1.53] xref: EC:2.7.1.53 xref: MetaCyc:LYXK-RXN is_a: GO:0004856 ! xylulokinase activity [Term] id: GO:0008745 name: N-acetylmuramoyl-L-alanine amidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28] subset: gosubset_prok synonym: "acetylmuramoyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "murein hydrolase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramic acid L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramylalanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "peptidoglycan amidohydrolase activity" EXACT [EC:3.5.1.28] xref: EC:3.5.1.28 xref: MetaCyc:3.5.1.28-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008746 name: NAD(P)+ transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.1, EC:1.6.1.2] subset: gosubset_prok synonym: "energy-linked transhydrogenase" EXACT [EC:1.6.1.1, EC:1.6.1.2] synonym: "H+-thase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1, EC:1.6.1.2] xref: EC:1.6.1.- xref: KEGG:R00112 xref: Reactome:12610 "NAD(P)+ transhydrogenase activity" is_a: GO:0016652 ! oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor [Term] id: GO:0008747 name: N-acetylneuraminate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3, RHEA:23299] subset: gosubset_prok synonym: "acetylneuraminate lyase activity" EXACT [EC:4.1.3.3] synonym: "acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic lyase activity" EXACT [EC:4.1.3.3] synonym: "NALase activity" EXACT [EC:4.1.3.3] synonym: "NANA lyase activity" EXACT [EC:4.1.3.3] synonym: "neuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "NPL" RELATED [EC:4.1.3.3] synonym: "sialate lyase activity" EXACT [EC:4.1.3.3] synonym: "sialic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "sialic aldolase activity" EXACT [EC:4.1.3.3] xref: EC:4.1.3.3 xref: KEGG:R01811 xref: MetaCyc:ACNEULY-RXN xref: RHEA:23299 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008748 name: N-ethylmaleimide reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-ethylmaleimide + 2 H+ = N-ethylsuccinimide." [MetaCyc:RXN0-5101] subset: gosubset_prok xref: EC:1.-.-.- xref: MetaCyc:RXN0-5101 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0008750 name: NAD(P)+ transhydrogenase (AB-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+." [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf] subset: gosubset_prok synonym: "NAD(P) transhydrogenase (AB-specific) activity" EXACT [EC:1.6.1.2] synonym: "NADPH:NAD+ oxidoreductase (AB-specific)" EXACT [EC:1.6.1.2] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.2] synonym: "transhydrogenase activity" BROAD [EC:1.6.1.2] xref: EC:1.6.1.2 xref: MetaCyc:1.6.1.2-RXN is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity [Term] id: GO:0008751 name: NAD(P)H dehydrogenase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a redundant grouping term with only one child. is_obsolete: true consider: GO:0016651 [Term] id: GO:0008752 name: FMN reductase activity namespace: molecular_function def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+." [EC:1.5.1.29] subset: gosubset_prok synonym: "flavin mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "flavine mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "FMNH2:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT [] synonym: "NAD(P)H(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-dependent FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2 dehydrogenase (FMN)" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:flavin oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "SsuE" RELATED [EC:1.5.1.29] xref: EC:1.5.1.29 xref: MetaCyc:FMNREDUCT-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0008753 name: NADPH dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [EC:1.6.99.6] subset: gosubset_prok synonym: "NADPH oxidase" BROAD [EC:1.6.99.6] synonym: "NADPH:(quinone-acceptor) oxidoreductase" EXACT [EC:1.6.99.6] synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" EXACT [EC:1.6.99.6] xref: EC:1.6.99.6 xref: MetaCyc:NADPH-DEHYDROGENASE-QUINONE-RXN is_a: GO:0003959 ! NADPH dehydrogenase activity [Term] id: GO:0008754 name: O antigen ligase activity namespace: molecular_function def: "Catalysis of the reaction: Lipid A-core + colanic acid = MLPS." [MetaCyc:RXN0-5294] xref: MetaCyc:RXN0-5294 is_a: GO:0016874 ! ligase activity [Term] id: GO:0008755 name: O antigen polymerase activity namespace: molecular_function def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, PMID:12045108] subset: gosubset_prok synonym: "O-antigen polymerase activity" EXACT [] xref: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008756 name: o-succinylbenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate ." [EC:6.2.1.26] subset: gosubset_prok synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-CoA synthetase activity" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.26] synonym: "OSB-CoA synthetase activity" EXACT [EC:6.2.1.26] synonym: "osb-CoA synthetase activity" EXACT [EC:6.2.1.26] xref: EC:6.2.1.26 xref: KEGG:R04030 xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN xref: RHEA:17012 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008757 name: S-adenosylmethionine-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] subset: gosubset_prok synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT [] synonym: "SAM-dependent methyltransferase activity" EXACT [] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008758 name: UDP-2,3-diacylglucosamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770] subset: gosubset_prok xref: EC:3.6.1.- xref: MetaCyc:LIPIDXSYNTHESIS-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008759 name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity namespace: molecular_function def: "Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271] subset: gosubset_prok xref: EC:3.5.1.- is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008760 name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7, RHEA:18684] subset: gosubset_prok synonym: "enoylpyruvate transferase activity" EXACT [EC:2.5.1.7] synonym: "MurA transferase activity" NARROW [EC:2.5.1.7] synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-UDP-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" EXACT [EC:2.5.1.7] xref: EC:2.5.1.7 xref: KEGG:R00660 xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN xref: RHEA:18684 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008761 name: UDP-N-acetylglucosamine 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14] subset: gosubset_prok synonym: "UDP-GlcNAc-2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] xref: EC:5.1.3.14 xref: MetaCyc:UDPGLCNACEPIM-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008762 name: UDP-N-acetylmuramate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] subset: gosubset_prok synonym: "MurB reductase" RELATED [EC:1.1.1.158] synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.158] synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" EXACT [EC:1.1.1.158] xref: EC:1.1.1.158 xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008763 name: UDP-N-acetylmuramate-L-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8, RHEA:23375] subset: gosubset_prok synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8] synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8] synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-MurNAc:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDPMurNAc-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] xref: EC:6.3.2.8 xref: KEGG:R03193 xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN xref: RHEA:23375 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008764 name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [EC:6.3.2.9, RHEA:16432] subset: gosubset_prok synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9] synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9] synonym: "MurD synthetase activity" EXACT [EC:6.3.2.9] synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] xref: EC:6.3.2.9 xref: KEGG:R02783 xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN xref: RHEA:16432 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008765 name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13, RHEA:23679] subset: gosubset_prok synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" EXACT [EC:6.3.2.13] xref: EC:6.3.2.13 xref: KEGG:R02788 xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN xref: RHEA:23679 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008766 name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [EC:6.3.2.15] comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10). subset: gosubset_prok xref: EC:6.3.2.- xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008767 name: UDP-galactopyranose mutase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9] subset: gosubset_prok synonym: "UDP-D-galactopyranose furanomutase activity" EXACT [EC:5.4.99.9] synonym: "UDPgalactopyranose mutase activity" EXACT [EC:5.4.99.9] xref: EC:5.4.99.9 xref: MetaCyc:GALPMUT-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0008768 name: UDP-sugar diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45] subset: gosubset_prok synonym: "nucleosidediphosphate-sugar diphosphatase activity" EXACT [EC:3.6.1.45] synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar hydrolase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.45] xref: EC:3.6.1.45 xref: MetaCyc:UDPSUGARHYDRO-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008769 name: X-His dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminoacyl-histidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "aminoacylhistidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "carnosinase activity" RELATED [EC:3.4.13.3] synonym: "dipeptidase M" RELATED [EC:3.4.13.3] synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3] synonym: "Xaa-His dipeptidase activity" EXACT [] xref: EC:3.4.13.3 xref: MetaCyc:3.4.13.3-RXN is_obsolete: true replaced_by: GO:0008235 replaced_by: GO:0016805 [Term] id: GO:0008770 name: [acyl-carrier-protein] phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14] subset: gosubset_prok synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT [] synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "ACP hydrolyase activity" EXACT [EC:3.1.4.14] synonym: "ACP phosphodiesterase activity" EXACT [] synonym: "AcpH" RELATED [EC:3.1.4.14] synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14] synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] xref: EC:3.1.4.14 xref: MetaCyc:3.1.4.14-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0008771 name: [citrate (pro-3S)-lyase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22] subset: gosubset_prok synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" EXACT [EC:6.2.1.22] synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22] synonym: "acetate:HS-citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate (pro-3S)-lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22] xref: EC:6.2.1.22 xref: KEGG:R04449 xref: MetaCyc:CITC-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008772 name: [isocitrate dehydrogenase (NADP+)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5] subset: gosubset_prok synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" EXACT [EC:2.7.11.5] synonym: "ICDH kinase/phosphatase activity" EXACT [EC:2.7.11.5] synonym: "IDH kinase activity" EXACT [EC:2.7.11.5] synonym: "IDH kinase/phosphatase activity" EXACT [EC:2.7.11.5] synonym: "IDH-K/P" RELATED [EC:2.7.11.5] synonym: "IDHK/P" RELATED [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP+) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase/phosphatase activity" EXACT [EC:2.7.11.5] synonym: "STK3" RELATED [EC:2.7.11.5] xref: EC:2.7.11.5 xref: MetaCyc:PHOSICITDEHASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0008773 name: [protein-PII] uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59] subset: gosubset_prok synonym: "PII uridylyl-transferase activity" EXACT [EC:2.7.7.59] synonym: "protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59] synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT [] synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] xref: EC:2.7.7.59 xref: MetaCyc:URITRANS-RXN is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0008774 name: acetaldehyde dehydrogenase (acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10] subset: gosubset_prok synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.10] synonym: "acylating acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.10] synonym: "ADA" RELATED [EC:1.2.1.10] synonym: "aldehyde dehydrogenase (acylating) activity" EXACT [EC:1.2.1.10] synonym: "DmpF" RELATED [EC:1.2.1.10] xref: EC:1.2.1.10 xref: MetaCyc:ACETALD-DEHYDROG-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008775 name: acetate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8] subset: gosubset_prok synonym: "acetate coenzyme A-transferase activity" EXACT [EC:2.8.3.8] synonym: "acetyl-CoA:acetoacetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "acyl-CoA:acetate CoA-transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl coenzyme A transferase activity" EXACT [EC:2.8.3.8] synonym: "succinyl-CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] xref: EC:2.8.3.8 xref: MetaCyc:ACECOATRANS-RXN xref: UM-BBD_enzymeID:e0012 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008776 name: acetate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1] subset: gosubset_prok synonym: "acetate kinase (phosphorylating) activity" EXACT [EC:2.7.2.1] synonym: "acetic kinase activity" EXACT [EC:2.7.2.1] synonym: "acetokinase activity" EXACT [EC:2.7.2.1] synonym: "AckA" RELATED [EC:2.7.2.1] synonym: "AK activity" EXACT [EC:2.7.2.1] synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1] xref: EC:2.7.2.1 xref: MetaCyc:ACETATEKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008777 name: acetylornithine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N2-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] xref: EC:3.5.1.16 xref: MetaCyc:ACETYLORNDEACET-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008779 name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40] synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXACT [EC:2.3.1.40] synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40] xref: EC:2.3.1.40 xref: MetaCyc:ACYLGPEACYLTRANS-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0008780 name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129] subset: gosubset_prok synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" EXACT [EC:2.3.1.129] synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129] synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] xref: EC:2.3.1.129 xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0008781 name: N-acylneuraminate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43] subset: gosubset_prok synonym: "acetylneuraminate cytidylyltransferase activity" EXACT [EC:2.7.7.43] synonym: "acylneuraminate cytidyltransferase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NANA synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-Neu5Ac synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuNAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate diphosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic synthetase activity" EXACT [EC:2.7.7.43] synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT [] synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5'-monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphoacetylneuraminic synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] xref: EC:2.7.7.43 xref: MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0008782 name: adenosylhomocysteine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9] subset: gosubset_prok synonym: "5'-methyladenosine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "AdoHcy/MTA nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9] synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9] xref: EC:3.2.2.9 xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008783 name: agmatinase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + H(2)O = putrescine + urea." [EC:3.5.3.11, RHEA:13932] subset: gosubset_prok synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11] synonym: "agmatine ureohydrolase activity" EXACT [EC:3.5.3.11] synonym: "SpeB" RELATED [EC:3.5.3.11] xref: EC:3.5.3.11 xref: KEGG:R01157 xref: MetaCyc:AGMATIN-RXN xref: Reactome:26116 "agmatinase activity" xref: RHEA:13932 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0008784 name: alanine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1, RHEA:20252] subset: gosubset_prok synonym: "L-alanine racemase activity" EXACT [EC:5.1.1.1] xref: EC:5.1.1.1 xref: KEGG:R00401 xref: MetaCyc:ALARACECAT-RXN xref: RHEA:20252 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008785 name: alkyl hydroperoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [UM-BBD_reactionID:r0684] subset: gosubset_prok xref: EC:1.8.1.- xref: UM-BBD_reactionID:r0684 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0008786 name: allose 6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [MetaCyc:RXN0-303] xref: EC:5.3.1.- xref: MetaCyc:RXN0-303 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008787 name: allose kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55] subset: gosubset_prok synonym: "allokinase (phosphorylating)" EXACT [EC:2.7.1.55] synonym: "allokinase activity" EXACT [EC:2.7.1.55] synonym: "ATP:D-allose 6-phosphotransferase activity" EXACT [EC:2.7.1.55] synonym: "D-allokinase activity" EXACT [EC:2.7.1.55] synonym: "D-allose-6-kinase activity" EXACT [EC:2.7.1.55] xref: EC:2.7.1.55 xref: MetaCyc:ALLOSE-KINASE-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008788 name: alpha,alpha-phosphotrehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93] subset: gosubset_prok synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" EXACT [EC:3.2.1.93] synonym: "phosphotrehalase activity" EXACT [EC:3.2.1.93] synonym: "trehalose-6-phosphate hydrolase activity" EXACT [EC:3.2.1.93] xref: EC:3.2.1.93 xref: MetaCyc:TRE6PHYDRO-RXN is_a: GO:0015927 ! trehalase activity [Term] id: GO:0008789 name: altronate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.7, RHEA:15960] subset: gosubset_prok synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.7] synonym: "D-altronate hydro-lyase activity" EXACT [EC:4.2.1.7] xref: EC:4.2.1.7 xref: KEGG:R01540 xref: MetaCyc:ALTRODEHYDRAT-RXN xref: RHEA:15960 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008790 name: arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3] synonym: "D-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3] synonym: "D-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose(L-fucose) isomerase activity" EXACT [EC:5.3.1.3] xref: EC:5.3.1.3 xref: MetaCyc:DARABISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008791 name: arginine N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109] subset: gosubset_prok synonym: "AOST activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N(2)-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "AST activity" EXACT [EC:2.3.1.109] synonym: "AstA" RELATED [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] xref: EC:2.3.1.109 xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0008792 name: arginine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H(+) = agmatine + CO(2)." [EC:4.1.1.19, RHEA:17644] subset: gosubset_prok synonym: "L-arginine carboxy-lyase (agmatine-forming)" EXACT [EC:4.1.1.19] synonym: "L-arginine carboxy-lyase activity" EXACT [EC:4.1.1.19] synonym: "SpeA" RELATED [EC:4.1.1.19] xref: EC:4.1.1.19 xref: KEGG:R00566 xref: MetaCyc:ARGDECARBOX-RXN xref: Reactome:26125 "arginine decarboxylase activity" xref: RHEA:17644 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008793 name: aromatic-amino-acid:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [EC:2.6.1.57] subset: gosubset_prok synonym: "ArAT" RELATED [EC:2.6.1.57] synonym: "aromatic amino acid aminotransferase activity" EXACT [EC:2.6.1.57] synonym: "aromatic amino acid transferase activity" EXACT [] synonym: "aromatic aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid transaminase activity" EXACT [EC:2.6.1.57] xref: EC:2.6.1.57 xref: MetaCyc:2.6.1.57-RXN xref: UM-BBD_reactionID:r0297 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008794 name: arsenate reductase (glutaredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884] subset: gosubset_prok synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1] xref: EC:1.20.4.1 xref: MetaCyc:RXN-982 xref: UM-BBD_reactionID:r0635 is_a: GO:0030611 ! arsenate reductase activity is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor [Term] id: GO:0008795 name: NAD+ synthase activity namespace: molecular_function alt_id: GO:0008749 alt_id: GO:0016965 def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5] subset: gosubset_prok synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.5] synonym: "diphosphopyridine nucleotide synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD synthase (AMP-forming)" EXACT [] synonym: "NAD synthase activity" EXACT [] synonym: "NAD synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD(+) synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD+ synthetase activity" EXACT [EC:6.3.1.5] synonym: "nicotinamide adenine dinucleotide synthetase activity" EXACT [EC:6.3.1.5] xref: EC:6.3.1.5 xref: MetaCyc:NAD-SYNTH-NH3-RXN is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0008796 name: bis(5'-nucleosyl)-tetraphosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai] subset: gosubset_prok xref: EC:3.6.1.- is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0008797 name: aspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1] subset: gosubset_prok synonym: "aspartase activity" EXACT [EC:4.3.1.1] synonym: "fumaric aminase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase (fumarate-forming)" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.1] xref: EC:4.3.1.1 xref: MetaCyc:ASPARTASE-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008798 name: beta-aspartyl-peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5] subset: gosubset_prok synonym: "beta-aspartyl dipeptidase activity" EXACT [EC:3.4.19.5] synonym: "beta-aspartyl peptidase activity" EXACT [EC:3.4.19.5] xref: EC:3.4.19.5 xref: MetaCyc:3.4.19.5-RXN is_a: GO:0008242 ! omega peptidase activity [Term] id: GO:0008800 name: beta-lactamase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6] subset: gosubset_prok synonym: "ampicillinase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactam hydrolase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6] synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6] synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6] synonym: "cephalosporin-beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "exopenicillinase activity" EXACT [EC:3.5.2.6] synonym: "neutrapen" RELATED [EC:3.5.2.6] synonym: "penicillin amido-beta-lactamhydrolase activity" EXACT [EC:3.5.2.6] synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "penicillinase I, II" RELATED [EC:3.5.2.6] xref: EC:3.5.2.6 xref: MetaCyc:BETA-LACTAMASE-RXN is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0008801 name: beta-phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6, RHEA:20116] subset: gosubset_prok synonym: "beta-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.6] xref: EC:5.4.2.6 xref: KEGG:R02728 xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN xref: RHEA:20116 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008802 name: betaine-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8] subset: gosubset_prok synonym: "BADH activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde dehydrogenase activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde oxidase activity" EXACT [EC:1.2.1.8] synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.8] synonym: "BetB" RELATED [EC:1.2.1.8] xref: EC:1.2.1.8 xref: MetaCyc:BADH-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008803 name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+)." [EC:3.6.1.41, RHEA:24255] subset: gosubset_prok synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "adenosine tetraphosphate phosphodiesterase activity" EXACT [EC:3.6.1.41] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "bis(5'-adenosyl) tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine polyphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW [] synonym: "diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosinetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] xref: EC:3.6.1.41 xref: KEGG:R00125 xref: MetaCyc:3.6.1.41-RXN xref: RHEA:24255 is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: GO:0008804 name: carbamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2] subset: gosubset_prok synonym: "ATP:carbamate phosphotransferase activity" EXACT [EC:2.7.2.2] synonym: "carbamoyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "carbamyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "CKase activity" EXACT [EC:2.7.2.2] xref: EC:2.7.2.2 xref: MetaCyc:CARBAMATE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008805 name: carbon-monoxide oxygenase activity namespace: molecular_function alt_id: GO:0018999 alt_id: GO:0047767 def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [EC:1.2.2.4] synonym: "carbon monoxide oxidase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [EC:1.2.2.4] synonym: "carbon monoxide oxygenase activity" EXACT [] synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW [EC:1.2.2.4] synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4] synonym: "cytochrome b561" NARROW [] xref: EC:1.2.2.4 xref: MetaCyc:1.2.2.4-RXN xref: UM-BBD_reactionID:r0650 xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561) is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0008806 name: carboxymethylenebutenolidase activity namespace: molecular_function alt_id: GO:0018735 def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45] subset: gosubset_prok synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" EXACT [EC:3.1.1.45] synonym: "carboxymethylene butenolide hydrolase activity" EXACT [EC:3.1.1.45] synonym: "dienelactone hydrolase activity" EXACT [EC:3.1.1.45] synonym: "maleylacetate enol-lactonase activity" EXACT [EC:3.1.1.45] xref: EC:3.1.1.45 xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN xref: UM-BBD_enzymeID:e0066 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0008807 name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23] subset: gosubset_prok synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" EXACT [EC:2.7.8.23] synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" EXACT [EC:2.7.8.23] synonym: "CPEP phosphonomutase activity" EXACT [EC:2.7.8.23] xref: EC:2.7.8.23 xref: MetaCyc:2.7.8.23-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008808 name: cardiolipin synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol + glycerol." [GOC:jl] subset: gosubset_prok synonym: "cardiolipin synthetase activity" BROAD [] synonym: "diphosphatidylglycerol synthase activity" EXACT [] xref: EC:2.7.8.- xref: MetaCyc:CARDIOLIPSYN-RXN is_a: GO:0030572 ! phosphatidyltransferase activity [Term] id: GO:0008809 name: carnitine racemase activity namespace: molecular_function def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN] xref: EC:5.1.-.- xref: MetaCyc:CARNRACE-RXN is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0008810 name: cellulase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4] subset: gosubset_prok synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.4] synonym: "9.5 cellulase activity" EXACT [EC:3.2.1.4] synonym: "alkali cellulase activity" EXACT [EC:3.2.1.4] synonym: "avicelase activity" BROAD [EC:3.2.1.4] synonym: "beta-1,4-endoglucan hydrolase activity" EXACT [EC:3.2.1.4] synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4] synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4] synonym: "celluase A" RELATED [EC:3.2.1.4] synonym: "celludextrinase activity" EXACT [EC:3.2.1.4] synonym: "cellulase A 3" RELATED [EC:3.2.1.4] synonym: "cellulosin AP" RELATED [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.4] synonym: "endo-1,4-beta-glucanase activity" EXACT [EC:3.2.1.4] synonym: "endoglucanase activity" EXACT [EC:3.2.1.4] synonym: "endoglucanase D" RELATED [EC:3.2.1.4] synonym: "pancellase SS" RELATED [EC:3.2.1.4] xref: EC:3.2.1.4 xref: MetaCyc:RXN-2043 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0008811 name: chloramphenicol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate + CoA." [EC:2.3.1.28, RHEA:18424] subset: gosubset_prok synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "CAT I" RELATED [EC:2.3.1.28] synonym: "CAT II" RELATED [EC:2.3.1.28] synonym: "CAT III" RELATED [EC:2.3.1.28] synonym: "chloramphenicol acetylase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol transacetylase activity" EXACT [EC:2.3.1.28] xref: EC:2.3.1.28 xref: KEGG:R03065 xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN xref: RHEA:18424 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008812 name: choline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] subset: gosubset_prok synonym: "choline oxidase activity" BROAD [EC:1.1.99.1] synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1] synonym: "choline:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.1] xref: EC:1.1.99.1 xref: KEGG:R01025 xref: MetaCyc:CHD-RXN xref: RHEA:17436 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0008813 name: chorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, RHEA:16508] subset: gosubset_prok synonym: "4-hydroxybenzoate synthetase activity" EXACT [] synonym: "chorismate pyruvate lyase activity" EXACT [] synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" EXACT [EC:4.1.3.40] synonym: "CL" RELATED [EC:4.1.3.40] synonym: "CPL" RELATED [EC:4.1.3.40] synonym: "UbiC" RELATED [EC:4.1.3.40] xref: EC:4.1.3.40 xref: KEGG:R01302 xref: MetaCyc:CHORPYRLY-RXN xref: RHEA:16508 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008814 name: citrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10] subset: gosubset_prok synonym: "acetyl-CoA:citrate CoA-transferase activity" EXACT [EC:2.8.3.10] xref: EC:2.8.3.10 xref: MetaCyc:CITTRANS-RXN is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008815 name: citrate (pro-3S)-lyase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [EC:4.1.3.6, RHEA:10763] subset: gosubset_prok synonym: "citrase activity" EXACT [EC:4.1.3.6] synonym: "citratase activity" EXACT [EC:4.1.3.6] synonym: "citrate aldolase activity" EXACT [EC:4.1.3.6] synonym: "citrate lyase activity" EXACT [] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6] synonym: "citrate oxaloacetate-lyase activity" EXACT [EC:4.1.3.6] synonym: "citric aldolase activity" EXACT [EC:4.1.3.6] synonym: "citridesmolase activity" EXACT [EC:4.1.3.6] synonym: "citritase activity" EXACT [EC:4.1.3.6] xref: EC:4.1.3.6 xref: KEGG:R00362 xref: MetaCyc:CITLY-RXN xref: Reactome:26375 "citrate (pro-3S)-lyase activity" xref: RHEA:10763 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008816 name: citryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34] subset: gosubset_prok synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.34] synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" EXACT [EC:4.1.3.34] xref: EC:4.1.3.34 xref: MetaCyc:CITRYLY-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008817 name: cob(I)yrinic acid a,c-diamide adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17] subset: gosubset_prok synonym: "aquacob(I)alamin adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17] synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:corrinoid adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "cob(I)alamin adenosyltransferase activity" EXACT [] synonym: "CobA" RELATED [EC:2.5.1.17] synonym: "vitamin B12s adenosyltransferase activity" EXACT [EC:2.5.1.17] xref: EC:2.5.1.17 xref: MetaCyc:COBALADENOSYLTRANS-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008818 name: cobalamin 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN] subset: gosubset_prok xref: MetaCyc:COBALAMIN5PSYN-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008819 name: cobinamide kinase activity namespace: molecular_function def: "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [http://www.mblab.gla.ac.uk/, PMID:1655696] subset: gosubset_prok xref: EC:2.7.1.- is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008820 name: cobinamide phosphate guanylyltransferase activity namespace: molecular_function alt_id: GO:0043753 def: "Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H(+) = adenosylcobinamide-GDP + diphosphate." [EC:2.7.7.62, RHEA:22715] subset: gosubset_prok synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] synonym: "adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] synonym: "CobU" RELATED [] synonym: "GTP:adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT [] xref: EC:2.7.7.62 xref: KEGG:R05222 xref: MetaCyc:COBINPGUANYLYLTRANS-RXN xref: RHEA:22715 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008821 name: crossover junction endodeoxyribonuclease activity namespace: molecular_function alt_id: GO:0008844 def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4] synonym: "crossover junction endoribonuclease activity" EXACT [] synonym: "cruciform-cutting endonuclease activity" EXACT [EC:3.1.22.-] synonym: "endo X3" RELATED [EC:3.1.22.4] synonym: "Endo X3 activity" NARROW [EC:3.1.22.-] synonym: "endodeoxyribonuclease RUS activity" EXACT [] synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-] synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-] synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-] synonym: "Hje endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction nuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction-cleaving endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-] synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-] synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-] synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-] synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-] xref: EC:3.1.22.4 xref: MetaCyc:3.1.22.4-RXN is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0008822 name: crotonobetaine/carnitine-CoA ligase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a bifunctional gene product. is_obsolete: true replaced_by: GO:0051108 replaced_by: GO:0051109 [Term] id: GO:0008823 name: cupric reductase activity namespace: molecular_function def: "Catalysis of the reaction: Cu+ + NAD+ = Cu2+ + NADH." [PMID:10510271] xref: EC:1.16.1.- is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0008824 name: cyanate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyanate + H2O = carbamate." [EC:4.2.1.104] comment: Note that this function was formerly EC:4.3.99.1. subset: gosubset_prok synonym: "carbamate hydro-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanase activity" EXACT [] synonym: "cyanate aminohydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate C-N-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanate hydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate lyase activity" EXACT [] xref: EC:4.2.1.104 xref: MetaCyc:R524-RXN xref: UM-BBD_reactionID:r0608 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0008825 name: cyclopropane-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79] subset: gosubset_prok synonym: "CFA synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthetase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" EXACT [EC:2.1.1.79] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79] xref: EC:2.1.1.79 xref: MetaCyc:2.1.1.79-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008826 name: cysteine sulfinate desulfinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite." [MetaCyc:RXN0-279] synonym: "cysteine sulphinate desulphinase activity" EXACT [] xref: EC:4.4.1.- xref: MetaCyc:RXN0-279 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0008827 name: cytochrome o ubiquinol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2O; cytochrome O is the electron acceptor." [GOC:mah, MetaCyc:CYT-UBIQUINOL-OXID-RXN] subset: gosubset_prok xref: EC:1.10.3.- is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008828 name: dATP pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate." [MetaCyc:RXN0-384] subset: gosubset_prok xref: EC:3.6.1.- xref: MetaCyc:RXN0-384 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0008829 name: dCTP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13] subset: gosubset_prok synonym: "5-methyl-dCTP deaminase activity" EXACT [EC:3.5.4.13] synonym: "dCTP aminohydrolase activity" EXACT [EC:3.5.4.13] synonym: "deoxycytidine triphosphate deaminase activity" EXACT [EC:3.5.4.13] xref: EC:3.5.4.13 xref: MetaCyc:DCTP-DEAM-RXN xref: Reactome:26405 "dCTP deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008830 name: dTDP-4-dehydrorhamnose 3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13, RHEA:16972] subset: gosubset_prok synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "dTDP-L-rhamnose synthetase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13] xref: EC:5.1.3.13 xref: KEGG:R06514 xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN xref: RHEA:16972 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008831 name: dTDP-4-dehydrorhamnose reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21799] subset: gosubset_prok synonym: "dTDP-4-keto-L-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.133] synonym: "reductase, thymidine diphospho-4-ketorhamnose" EXACT [EC:1.1.1.133] synonym: "TDP-4-keto-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "thymidine diphospho-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] xref: EC:1.1.1.133 xref: KEGG:R02777 xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN xref: RHEA:21799 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008832 name: dGTPase activity namespace: molecular_function def: "Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate." [EC:3.1.5.1, RHEA:15196] subset: gosubset_prok synonym: "deoxy-GTPase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphatase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT [] synonym: "dGTP triphosphohydrolase activity" EXACT [EC:3.1.5.1] xref: EC:3.1.5.1 xref: KEGG:R01856 xref: MetaCyc:DGTPTRIPHYDRO-RXN xref: RHEA:15196 is_a: GO:0016793 ! triphosphoric monoester hydrolase activity [Term] id: GO:0008833 name: deoxyribonuclease IV (phage-T4-induced) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2] subset: gosubset_prok synonym: "deoxriboendonuclease activity" EXACT [EC:3.1.21.2] synonym: "deoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "DNA-adenine-transferase activity" EXACT [EC:3.1.21.2] synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" EXACT [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "endonuclease II" RELATED [EC:3.1.21.2] synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2] synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2] synonym: "redoxyendonuclease activity" EXACT [EC:3.1.21.2] xref: EC:3.1.21.2 xref: MetaCyc:3.1.21.2-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008834 name: di-trans,poly-cis-decaprenylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31] subset: gosubset_prok synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31] synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" EXACT [EC:2.5.1.31] synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl diphosphate synthase activity" EXACT [] synonym: "undecaprenyl diphosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "UPP synthetase activity" EXACT [EC:2.5.1.31] xref: EC:2.5.1.31 xref: MetaCyc:RXN-8999 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0008835 name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity namespace: molecular_function alt_id: GO:0008485 def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+)." [EC:3.5.4.26, RHEA:21871] subset: gosubset_prok synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT [] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] xref: EC:3.5.4.26 xref: KEGG:R03459 xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN xref: RHEA:21871 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008836 name: diaminopimelate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2)." [EC:4.1.1.20, RHEA:15104] subset: gosubset_prok synonym: "DAP decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "DAP-decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "diaminopimelic acid decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" EXACT [EC:4.1.1.20] synonym: "meso-diaminopimelate decarboxylase activity" EXACT [EC:4.1.1.20] xref: EC:4.1.1.20 xref: KEGG:R00451 xref: MetaCyc:DIAMINOPIMDECARB-RXN xref: RHEA:15104 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008837 name: diaminopimelate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate." [EC:5.1.1.7, RHEA:15396] subset: gosubset_prok synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" EXACT [EC:5.1.1.7] xref: EC:5.1.1.7 xref: KEGG:R02735 xref: MetaCyc:DIAMINOPIMEPIM-RXN xref: RHEA:15396 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008838 name: diaminopropionate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15] subset: gosubset_prok synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" EXACT [EC:4.3.1.15] synonym: "2,3-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "diaminopropionatase activity" EXACT [EC:4.3.1.15] xref: EC:4.3.1.15 xref: MetaCyc:4.3.1.15-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008839 name: dihydrodipicolinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+." [EC:1.3.1.26] subset: gosubset_prok synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.26] synonym: "dihydrodipicolinic acid reductase activity" EXACT [EC:1.3.1.26] xref: EC:1.3.1.26 xref: MetaCyc:DIHYDROPICRED-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008840 name: dihydrodipicolinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydrodipicolinate + 2 H(2)O + H(+)." [EC:4.2.1.52, RHEA:14848] subset: gosubset_prok synonym: "DHDPS activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinic acid synthase activity" EXACT [EC:4.2.1.52] synonym: "dihydropicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED [EC:4.2.1.52] xref: EC:4.2.1.52 xref: KEGG:R02292 xref: MetaCyc:DIHYDRODIPICSYN-RXN xref: RHEA:14848 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008841 name: dihydrofolate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12] subset: gosubset_prok synonym: "7,8-dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.12] synonym: "DHFS activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" EXACT [EC:6.3.2.12] synonym: "FHFS activity" EXACT [EC:6.3.2.12] synonym: "FHFS/FPGS activity" EXACT [EC:6.3.2.12] synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" EXACT [EC:6.3.2.12] synonym: "H(2)-folate synthetase activity" EXACT [EC:6.3.2.12] synonym: "H2-folate synthetase activity" EXACT [EC:6.3.2.12] xref: EC:6.3.2.12 xref: MetaCyc:DIHYDROFOLATESYNTH-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008842 name: diphosphate-purine nucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143] synonym: "diphosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "diphosphate:purine nucleoside phosphotransferase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-purine nucleoside kinase activity" EXACT [EC:2.7.1.143] xref: EC:2.7.1.143 xref: MetaCyc:2.7.1.143-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0008843 name: endochitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] is_a: GO:0004568 ! chitinase activity [Term] id: GO:0008845 name: endonuclease VIII activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12713806] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0000703 consider: GO:0003684 consider: GO:0003906 consider: GO:0004519 consider: GO:0008081 consider: GO:0019104 [Term] id: GO:0008846 name: endopeptidase La activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [EC:3.4.21.53] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "ATP-dependent lon proteinase" NARROW [EC:3.4.21.53] synonym: "ATP-dependent protease La activity" EXACT [EC:3.4.21.53] synonym: "ATP-dependent serine proteinase activity" RELATED [EC:3.4.21.53] synonym: "Escherichia coli proteinase La" RELATED [EC:3.4.21.53] synonym: "Escherichia coli serine proteinase La" RELATED [EC:3.4.21.53] synonym: "gene lon protease activity" EXACT [EC:3.4.21.53] synonym: "gene lon proteins" RELATED [EC:3.4.21.53] synonym: "lon proteinase" NARROW [EC:3.4.21.53] synonym: "PIM1 protease activity" EXACT [EC:3.4.21.53] synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53] synonym: "protease La" RELATED [EC:3.4.21.53] synonym: "proteinase La" RELATED [EC:3.4.21.53] synonym: "serine protease La" RELATED [EC:3.4.21.53] xref: EC:3.4.21.53 xref: MetaCyc:3.4.21.53-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008847 name: Enterobacter ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.6] subset: gosubset_prok synonym: "enterobacter ribonuclease activity" EXACT [EC:3.1.27.6] synonym: "Enterobacter RNase activity" EXACT [] xref: EC:3.1.27.6 xref: MetaCyc:3.1.27.6-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0008848 name: enterobactin synthetase namespace: molecular_function alt_id: GO:0008850 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a process rather than a function. synonym: "enterochelin synthetase activity" EXACT [] synonym: "nonribosomal peptide synthetase" RELATED [] is_obsolete: true replaced_by: GO:0009239 [Term] id: GO:0008849 name: enterochelin esterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the enterochelin group of ferric-enterochelin to yield ultimately three molecules of N-2,3-dihydroxybenzoylserine." [PMID:4565531] synonym: "enterobactin esterase activity" EXACT [] is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0008851 name: ethanolamine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7] subset: gosubset_prok synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" EXACT [EC:4.3.1.7] synonym: "ethanolamine deaminase activity" EXACT [EC:4.3.1.7] xref: EC:4.3.1.7 xref: MetaCyc:ETHAMLY-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008852 name: exodeoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.1] subset: gosubset_prok synonym: "E. coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "E. coli exonuclease I activity" NARROW [EC:3.1.11.1] synonym: "Escherichia coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "exonuclease I activity" RELATED [EC:3.1.11.1] xref: EC:3.1.11.1 xref: MetaCyc:3.1.11.1-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008853 name: exodeoxyribonuclease III activity namespace: molecular_function def: "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2] subset: gosubset_prok synonym: "E. coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "E. coli exonuclease III activity" NARROW [EC:3.1.11.2] synonym: "endoribonuclease III" RELATED [EC:3.1.11.2] synonym: "Escherichia coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "exonuclease III activity" EXACT [EC:3.1.11.2] xref: EC:3.1.11.2 xref: MetaCyc:3.1.11.2-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008854 name: exodeoxyribonuclease V activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5] subset: gosubset_prok synonym: "E. coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5] synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "exonuclease V activity" EXACT [EC:3.1.11.5] synonym: "gene recBC DNase activity" EXACT [EC:3.1.11.5] synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5] synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5] synonym: "RecBC deoxyribonuclease activity" EXACT [EC:3.1.11.5] xref: EC:3.1.11.5 xref: MetaCyc:3.1.11.5-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008855 name: exodeoxyribonuclease VII activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6] subset: gosubset_prok synonym: "E. coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6] synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6] synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "exonuclease VII activity" EXACT [EC:3.1.11.6] xref: EC:3.1.11.6 xref: MetaCyc:3.1.11.6-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008856 name: exodeoxyribonuclease X activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [EC:3.1.22.5] synonym: "deoxyribonuclease X activity" EXACT [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease activity" RELATED [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease X activity" NARROW [EC:3.1.22.5] xref: EC:3.1.11.- xref: MetaCyc:3.1.22.5-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008859 name: exoribonuclease II activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] subset: gosubset_prok synonym: "5'-exoribonuclease activity" EXACT [EC:3.1.13.1] synonym: "BN ribonuclease activity" EXACT [EC:3.1.13.1] synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1] synonym: "ribonuclease II activity" EXACT [EC:3.1.13.1] synonym: "ribonuclease Q" RELATED [EC:3.1.13.1] synonym: "RNase II" RELATED [EC:3.1.13.1] synonym: "RNase II activity" EXACT [] xref: EC:3.1.13.1 xref: MetaCyc:3.1.13.1-RXN is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008860 name: ferredoxin-NAD+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3] subset: gosubset_prok synonym: "ferredoxin-linked NAD reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin-NAD reductase activity" EXACT [] synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NAD-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH flavodoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" EXACT [EC:1.18.1.3] synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3] xref: EC:1.18.1.3 xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0008861 name: formate C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [EC:2.3.1.54] subset: gosubset_prok synonym: "acetyl-CoA:formate C-acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "formate acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "pyruvate formate-lyase activity" EXACT [EC:2.3.1.54] synonym: "pyruvic formate-lyase activity" EXACT [EC:2.3.1.54] xref: EC:2.3.1.54 xref: MetaCyc:PYRUVFORMLY-RXN is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0008863 name: formate dehydrogenase (NAD+) activity namespace: molecular_function alt_id: GO:0018476 def: "Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH." [EC:1.2.1.2, RHEA:15988] subset: gosubset_prok synonym: "FDH I" RELATED [EC:1.2.1.2] synonym: "FDH II" RELATED [EC:1.2.1.2] synonym: "formate benzyl-viologen oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formate dehydrogenase (NAD)" EXACT [EC:1.2.1.2] synonym: "formate hydrogenlyase" EXACT [EC:1.2.1.2] synonym: "formate-NAD oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formate:NAD+ oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formic acid dehydrogenase" EXACT [EC:1.2.1.2] synonym: "formic hydrogen-lyase" EXACT [EC:1.2.1.2] synonym: "N-FDH" RELATED [EC:1.2.1.2] synonym: "NAD-dependent formate dehydrogenase" EXACT [EC:1.2.1.2] synonym: "NAD-formate dehydrogenase" EXACT [EC:1.2.1.2] synonym: "NAD-linked formate dehydrogenase" EXACT [EC:1.2.1.2] xref: EC:1.2.1.2 xref: KEGG:R00519 xref: MetaCyc:1.2.1.2-RXN xref: MetaCyc:FORMATEDEHYDROG-RXN xref: RHEA:15988 xref: UM-BBD_reactionID:r0103 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008864 name: formyltetrahydrofolate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)." [EC:3.5.1.10, RHEA:19836] subset: gosubset_prok synonym: "10-formyltetrahydrofolate amidohydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyl-FH(4) hydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyltetrahydrofolate hydrolase activity" EXACT [EC:3.5.1.10] xref: EC:3.5.1.10 xref: KEGG:R00944 xref: MetaCyc:FORMYLTHFDEFORMYL-RXN xref: RHEA:19836 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008865 name: fructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4] subset: gosubset_prok synonym: "ATP:D-fructose 6-phosphotransferase activity" EXACT [EC:2.7.1.4] synonym: "D-fructokinase activity" EXACT [EC:2.7.1.4] synonym: "D-fructose(D-mannose)kinase activity" EXACT [EC:2.7.1.4] synonym: "fructokinase (phosphorylating)" EXACT [EC:2.7.1.4] xref: EC:2.7.1.4 xref: MetaCyc:FRUCTOKINASE-RXN is_a: GO:0004396 ! hexokinase activity [Term] id: GO:0008866 name: fructuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH." [EC:1.1.1.57, RHEA:15732] subset: gosubset_prok synonym: "D-mannonate dehydrogenase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonic dehydrogenase activity" EXACT [EC:1.1.1.57] xref: EC:1.1.1.57 xref: KEGG:R02454 xref: MetaCyc:MANNONOXIDOREDUCT-RXN xref: RHEA:15732 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008867 name: galactarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O." [EC:4.2.1.42, RHEA:16008] subset: gosubset_prok synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.42] synonym: "D-galactarate hydro-lyase activity" EXACT [EC:4.2.1.42] xref: EC:4.2.1.42 xref: KEGG:R05608 xref: MetaCyc:GALACTARDEHYDRA-RXN xref: RHEA:16008 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008868 name: galactitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = L-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251] subset: gosubset_prok synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.251] xref: EC:1.1.1.251 xref: MetaCyc:1.1.1.251-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008869 name: galactonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O." [EC:4.2.1.6, RHEA:18652] subset: gosubset_prok synonym: "D-galactonate dehydrase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate dehydratase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase activity" EXACT [EC:4.2.1.6] xref: EC:4.2.1.6 xref: KEGG:R03033 xref: MetaCyc:GALACTONDEHYDRAT-RXN xref: RHEA:18652 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008870 name: galactoside O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18] subset: gosubset_prok synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "galactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18] xref: EC:2.3.1.18 xref: MetaCyc:GALACTOACETYLTRAN-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008871 name: aminoglycoside 2''-nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb] subset: gosubset_prok synonym: "2''-aminoglycoside nucleotidyltransferase activity" EXACT [EC:2.7.7.46] synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] xref: EC:2.7.7.46 xref: MetaCyc:2.7.7.46-RXN is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity [Term] id: GO:0008872 name: glucarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40] subset: gosubset_prok synonym: "D-glucarate dehydratase activity" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase activity" EXACT [EC:4.2.1.40] xref: EC:4.2.1.40 xref: MetaCyc:GLUCARDEHYDRA-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008873 name: gluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215] subset: gosubset_prok synonym: "2-keto-D-gluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "2-ketogluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "D-gluconate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.215] xref: EC:1.1.1.215 xref: MetaCyc:1.1.1.215-RXN is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0008874 name: gluconate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69] subset: gosubset_prok synonym: "5-keto-D-gluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-keto-D-gluconate reductase" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate reductase activity" EXACT [EC:1.1.1.69] synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" EXACT [EC:1.1.1.69] xref: EC:1.1.1.69 xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0008875 name: gluconate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215, EC:1.1.1.69] subset: gosubset_prok xref: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008876 name: quinoprotein glucose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [EC:1.1.5.2] comment: Note that this was EC:1.1.99.17. subset: gosubset_prok synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "D-glucose:ubiquinone oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (PQQ-dependent) activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT [] synonym: "quinoprotein D-glucose dehydrogenase activity" EXACT [EC:1.1.5.2] xref: EC:1.1.5.2 xref: MetaCyc:GLUCDEHYDROG-RXN is_a: GO:0004344 ! glucose dehydrogenase activity is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0008877 name: glucose-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10] subset: gosubset_prok synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] synonym: "D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] xref: EC:3.1.3.10 xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0008878 name: glucose-1-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate." [EC:2.7.7.27, RHEA:12123] subset: gosubset_prok synonym: "adenosine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "adenosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADGase activity" EXACT [] synonym: "ADP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose diphosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthetase activity" EXACT [EC:2.7.7.27] synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ADPG pyrophosphorylase activity" EXACT [] synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT [] synonym: "glucose 1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] xref: EC:2.7.7.27 xref: KEGG:R00948 xref: MetaCyc:GLUC1PADENYLTRANS-RXN xref: RHEA:12123 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008879 name: glucose-1-phosphate thymidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose." [EC:2.7.7.24, RHEA:15228] subset: gosubset_prok synonym: "dTDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose synthase activity" EXACT [EC:2.7.7.24] synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "glucose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "TDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] xref: EC:2.7.7.24 xref: KEGG:R02328 xref: MetaCyc:DTDPGLUCOSEPP-RXN xref: RHEA:15228 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0008880 name: glucuronate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronate = D-fructuronate." [EC:5.3.1.12] subset: gosubset_prok synonym: "D-glucuronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate ketol-isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic acid isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic isomerase activity" EXACT [EC:5.3.1.12] xref: EC:5.3.1.12 xref: MetaCyc:GLUCUROISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008881 name: glutamate racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3, RHEA:12816] subset: gosubset_prok xref: EC:5.1.1.3 xref: KEGG:R00260 xref: MetaCyc:GLUTRACE-RXN xref: RHEA:12816 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008882 name: [glutamate-ammonia-ligase] adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]." [EC:2.7.7.42] subset: gosubset_prok synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT [] synonym: "ATP:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT [] synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] xref: EC:2.7.7.42 xref: MetaCyc:GSADENYLATION-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008883 name: glutamyl-tRNA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH." [EC:1.2.1.70, RHEA:12347] subset: gosubset_prok synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" EXACT [EC:1.2.1.70] xref: EC:1.2.1.70 xref: KEGG:R04109 xref: MetaCyc:GLUTRNAREDUCT-RXN xref: RHEA:12347 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008884 name: glutathionylspermidine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" EXACT [EC:3.5.1.78] synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" EXACT [EC:3.5.1.78] synonym: "GSP amidase activity" EXACT [EC:3.5.1.78] xref: EC:3.5.1.78 xref: MetaCyc:GSPAMID-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008885 name: glutathionylspermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8] synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathione:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathionylspermidine synthetase activity" EXACT [EC:6.3.1.8] synonym: "GSP synthetase activity" EXACT [EC:6.3.1.8] xref: EC:6.3.1.8 xref: MetaCyc:GSPSYN-RXN is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0008886 name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(2)O + NADP(+) = 3-phospho-D-glycerate + 2 H(+) + NADPH." [EC:1.2.1.9, RHEA:14672] subset: gosubset_prok synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT [] synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD [] synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT [] synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD [] synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9] xref: EC:1.2.1.9 xref: KEGG:R01058 xref: MetaCyc:1.2.1.9-RXN xref: RHEA:14672 is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: GO:0008887 name: glycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+)." [EC:2.7.1.31, RHEA:23519] subset: gosubset_prok synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "ATP:D-glycerate 2-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate 3-kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glyceric acid kinase activity" EXACT [EC:2.7.1.31] synonym: "GK" RELATED [EC:2.7.1.31] synonym: "glycerate kinase (phosphorylating)" EXACT [EC:2.7.1.31] synonym: "glycerate-3-kinase activity" EXACT [EC:2.7.1.31] xref: EC:2.7.1.31 xref: KEGG:R01514 xref: MetaCyc:GLY3KIN-RXN xref: RHEA:23519 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008888 name: glycerol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NAD(+) = glycerone + H(+) + NADH." [EC:1.1.1.6, RHEA:13772] subset: gosubset_prok synonym: "NAD-linked glycerol dehydrogenase activity" EXACT [EC:1.1.1.6] xref: EC:1.1.1.6 xref: KEGG:R01034 xref: MetaCyc:GLYCDEH-RXN xref: RHEA:13772 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008889 name: glycerophosphodiester phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] subset: gosubset_prok synonym: "gene hpd protein" RELATED [EC:3.1.4.46] synonym: "glycerophosphodiester glycerophosphohydrolase activity" EXACT [EC:3.1.4.46] synonym: "glycerophosphoryl diester phosphodiesterase activity" EXACT [EC:3.1.4.46] synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46] xref: EC:3.1.4.46 xref: MetaCyc:GLYCPDIESTER-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0008890 name: glycine C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20739] subset: gosubset_prok synonym: "2-amino-3-ketobutyrate CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate coenzyme A ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate-CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "acetyl-CoA:glycine C-acetyltransferase activity" EXACT [EC:2.3.1.29] synonym: "aminoacetone synthase activity" EXACT [EC:2.3.1.29] synonym: "glycine acetyltransferase activity" EXACT [EC:2.3.1.29] xref: EC:2.3.1.29 xref: KEGG:R00371 xref: MetaCyc:AKBLIG-RXN xref: RHEA:20739 is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0008891 name: glycolate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide." [EC:1.1.3.15] subset: gosubset_prok xref: MetaCyc:RXN-969 xref: Reactome:26481 "glycolate oxidase activity" is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity [Term] id: GO:0008892 name: guanine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3] subset: gosubset_prok synonym: "GAH activity" EXACT [EC:3.5.4.3] synonym: "guanase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminohydrolase activity" EXACT [EC:3.5.4.3] xref: EC:3.5.4.3 xref: MetaCyc:GUANINE-DEAMINASE-RXN xref: Reactome:26482 "guanine deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008893 name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2] subset: gosubset_prok synonym: "(ppGpp)ase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT [] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT [] synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp phosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] xref: EC:3.1.7.2 xref: MetaCyc:PPGPPSYN-RXN is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] id: GO:0008894 name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40] subset: gosubset_prok synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT [] synonym: "pppGpp 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] xref: EC:3.6.1.40 xref: MetaCyc:PPPGPPHYDRO-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008897 name: holo-[acyl-carrier-protein] synthase activity namespace: molecular_function alt_id: GO:0008958 def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709] subset: gosubset_prok synonym: "4'-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "4'-phosphopantetheinyltransferase activity" EXACT [] synonym: "AcpS" RELATED [EC:2.7.8.7] synonym: "ACPS activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" EXACT [EC:2.7.8.7] synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7] synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT [] synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" EXACT [EC:2.7.8.7] synonym: "holo-[acyl-carrier-protein] synthase activity" NARROW [] synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW [] synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7] synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7] synonym: "holo-acyl-carrier-protein synthase activity" EXACT [EC:2.7.8.7] synonym: "holosynthase activity" RELATED [EC:2.7.8.7] synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7] synonym: "P-pant transferase activity" EXACT [EC:2.7.8.7] synonym: "phosphopantetheinyltransferase activity" EXACT [] synonym: "PPTase activity" EXACT [EC:2.7.8.7] xref: EC:2.7.8.7 xref: MetaCyc:HOLO-ACP-SYNTH-RXN xref: Reactome:26486 "holo-[acyl-carrier-protein] synthase activity" is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008898 name: homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10] subset: gosubset_prok synonym: "adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "methylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine-homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-methylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] xref: EC:2.1.1.10 xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008899 name: homoserine O-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA." [EC:2.3.1.46, RHEA:22011] subset: gosubset_prok synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46] synonym: "homoserine succinyltransferase activity" EXACT [EC:2.3.1.46] synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" EXACT [EC:2.3.1.46] xref: EC:2.3.1.46 xref: KEGG:R01777 xref: MetaCyc:HOMSUCTRAN-RXN xref: RHEA:22011 is_a: GO:0016750 ! O-succinyltransferase activity [Term] id: GO:0008900 name: hydrogen:potassium-exchanging ATPase activity namespace: molecular_function alt_id: GO:0005390 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [EC:3.6.3.10] subset: gosubset_prok synonym: "(K+ + H+)-ATPase activity" EXACT [EC:3.6.3.10] synonym: "ATP phosphohydrolase (H+/K+-exchanging)" EXACT [EC:3.6.3.10] synonym: "gastric H(+)/K(+) ATPase activity" NARROW [EC:3.6.3.10] synonym: "gastric H+/K+ ATPase" NARROW [EC:3.6.3.10] synonym: "H(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+-K+-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+/K+-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "h+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "H,K-ATPase activity" EXACT [EC:3.6.3.10] synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT [] synonym: "hydrogen:potassium exchanging ATPase activity" EXACT [] synonym: "proton pump activity" BROAD [EC:3.6.3.10] xref: EC:3.6.3.10 xref: Reactome:1381 "hydrogen:potassium-exchanging ATPase activity" is_a: GO:0008556 ! potassium-transporting ATPase activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity [Term] id: GO:0008901 name: ferredoxin hydrogenase activity namespace: molecular_function alt_id: GO:0016948 alt_id: GO:0016949 alt_id: GO:0016950 alt_id: GO:0016951 def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2] comment: Note that this function was formerly EC 1.12.1.1, EC 1.12.7.1, EC 1.98.1.1, EC 1.18.3.1 and EC 1.18.99.1. subset: gosubset_prok synonym: "[Fe] hydrogenase activity" EXACT [] synonym: "[Fe] hydrogenase gamma" RELATED [] synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H2 oxidizing hydrogenase" BROAD [] synonym: "H2 producing hydrogenase" BROAD [] synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2] synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT [] synonym: "hydrogenase (ferredoxin) activity" EXACT [EC:1.12.7.2] synonym: "hydrogenase activity" BROAD [] synonym: "hydrogenase I" RELATED [] synonym: "hydrogenase II" RELATED [] synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2] synonym: "iron hydrogenase activity" NARROW [] synonym: "iron-only hydrogenase activity" NARROW [] synonym: "Ni-Fe hydrogenase activity" NARROW [] synonym: "Ni-Fe-Se hydrogenase activity" NARROW [] synonym: "nickel hydrogenase activity" NARROW [] synonym: "nickel-iron hydrogenase activity" NARROW [] synonym: "nickel-iron-selenium hydrogenase activity" NARROW [] synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2] xref: EC:1.12.7.2 xref: MetaCyc:HYDROG-RXN xref: UM-BBD_enzymeID:e0418 is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor [Term] id: GO:0008902 name: hydroxymethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H(+)." [EC:2.7.1.49, RHEA:23099] subset: gosubset_prok synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" EXACT [EC:2.7.1.49] synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" EXACT [EC:2.7.1.49] xref: EC:2.7.1.49 xref: KEGG:R03471 xref: MetaCyc:OHMETPYRKIN-RXN xref: RHEA:23099 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008903 name: hydroxypyruvate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22, RHEA:11955] subset: gosubset_prok synonym: "hydroxypyruvate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.22] synonym: "hydroxypyruvate ketol-isomerase activity" EXACT [EC:5.3.1.22] xref: EC:5.3.1.22 xref: KEGG:R01394 xref: MetaCyc:RXN0-305 xref: RHEA:11955 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008904 name: hygromycin-B 7''-O-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H(+)." [EC:2.7.1.119, RHEA:23391] subset: gosubset_prok synonym: "APH(7'') activity" RELATED [EC:2.7.1.119] synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" EXACT [EC:2.7.1.119] synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT [] synonym: "hygromycin B kinase activity" BROAD [] synonym: "hygromycin B phosphotransferase activity" BROAD [EC:2.7.1.119] synonym: "hygromycin-B kinase activity" BROAD [] xref: EC:2.7.1.119 xref: KEGG:R03770 xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN xref: RHEA:23391 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0008905 name: mannose-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.7.7.- is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008906 name: inosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73] subset: gosubset_prok synonym: "ATP:inosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.73] synonym: "inosine kinase (phosphorylating)" EXACT [EC:2.7.1.73] synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73] xref: EC:2.7.1.73 xref: MetaCyc:INOSINEKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008907 name: integrase activity namespace: molecular_function def: "Catalysis of the integration of one segment of DNA into another." [GOC:mah] subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0008908 name: isochorismatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate." [EC:3.3.2.1, RHEA:11115] subset: gosubset_prok synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" EXACT [EC:3.3.2.1] synonym: "isochorismate pyruvate-hydrolase activity" EXACT [EC:3.3.2.1] xref: EC:3.3.2.1 xref: KEGG:R03037 xref: MetaCyc:ISOCHORMAT-RXN xref: RHEA:11115 is_a: GO:0004463 ! leukotriene-A4 hydrolase activity [Term] id: GO:0008909 name: isochorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.4.2, RHEA:18988] comment: Note that this function was formerly EC:5.4.99.6. subset: gosubset_prok synonym: "isochorismate hydroxymutase activity" EXACT [EC:5.4.4.2] synonym: "isochorismate mutase activity" EXACT [] synonym: "isochorismate synthetase activity" EXACT [EC:5.4.4.2] xref: EC:5.4.4.2 xref: KEGG:R01717 xref: MetaCyc:ISOCHORSYN-RXN xref: RHEA:18988 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0008910 name: kanamycin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate." [EC:2.7.1.95, RHEA:24259] subset: gosubset_prok synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "APH(3') activity" EXACT [EC:2.7.1.95] synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95] synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "neomycin-kanamycin phosphotransferase activity" EXACT [EC:2.7.1.95] xref: EC:2.7.1.95 xref: KEGG:R01888 xref: MetaCyc:KANAMYCIN-KINASE-RXN xref: RHEA:24259 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0008911 name: lactaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [EC:1.2.1.22] subset: gosubset_prok synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "L-lactaldehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" EXACT [EC:1.2.1.22] xref: EC:1.2.1.22 xref: MetaCyc:LACTALDDEHYDROG-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008912 name: lactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+." [EC:1.1.1.77] subset: gosubset_prok synonym: "(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "propanediol oxidoreductase activity" BROAD [EC:1.1.1.77] synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" EXACT [EC:1.1.1.77] xref: EC:1.1.1.77 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008913 name: lauroyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "lauroyl transferase activity" EXACT [] is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0008914 name: leucyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein." [EC:2.3.2.6] subset: gosubset_prok synonym: "L-leucyl-tRNA:protein leucyltransferase activity" EXACT [EC:2.3.2.6] synonym: "L/F transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl, phenylalanine-tRNA-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] xref: EC:2.3.2.6 xref: MetaCyc:LEUCYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0008915 name: lipid-A-disaccharide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H(+) + UDP." [EC:2.4.1.182, RHEA:22671] subset: gosubset_prok synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" EXACT [EC:2.4.1.182] xref: EC:2.4.1.182 xref: KEGG:R04606 xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN xref: RHEA:22671 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008917 name: lipopolysaccharide N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56] subset: gosubset_prok synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT [] synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] xref: EC:2.4.1.56 xref: MetaCyc:2.4.1.56-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008918 name: lipopolysaccharide 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44] subset: gosubset_prok synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "lipopolysaccharide galactosyltransferase activity" EXACT [] synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW [] synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] xref: EC:2.4.1.44 xref: MetaCyc:2.4.1.44-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008919 name: lipopolysaccharide glucosyltransferase I activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58] subset: gosubset_prok synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "LPS glucosyltransferase I activity" EXACT [] synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] xref: EC:2.4.1.58 xref: MetaCyc:2.4.1.58-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008920 name: lipopolysaccharide heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+." [MetaCyc:RXN0-5061, MetaCyc:RXN0-5122, MetaCyc:RXN0-5127] subset: gosubset_prok synonym: "LPS heptosyltransferase activity" EXACT [] is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008921 name: lipopolysaccharide-1,6-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai] synonym: "LPS-1,6-galactosyltransferase activity" EXACT [] xref: EC:2.4.1.- is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008922 name: long-chain fatty acid [acyl-carrier-protein] ligase activity namespace: molecular_function alt_id: GO:0010300 def: "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]." [EC:6.2.1.20] subset: gosubset_prok synonym: "acyl-[acyl-carrier-protein] synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-ACP synthetase activity" EXACT [] synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20] synonym: "acyl-acyl-carrier-protein synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-acyl-carrier-proteinsynthetase activity" EXACT [EC:6.2.1.20] synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-[acyl-carrier-protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT [] synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" EXACT [EC:6.2.1.20] synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" EXACT [EC:6.2.1.20] synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20] xref: EC:6.2.1.20 xref: KEGG:R07325 xref: MetaCyc:ACYLACPSYNTH-RXN is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008923 name: lysine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2)." [EC:4.1.1.18, RHEA:22355] subset: gosubset_prok synonym: "L-lysine carboxy-lyase (cadaverine-forming)" EXACT [EC:4.1.1.18] synonym: "L-lysine carboxy-lyase activity" EXACT [EC:4.1.1.18] xref: EC:4.1.1.18 xref: KEGG:R00462 xref: MetaCyc:LYSDECARBOX-RXN xref: MetaCyc:PWY0-461 xref: RHEA:22355 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008924 name: malate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol." [MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN] subset: gosubset_prok synonym: "(S)-malate:(quinone) oxidoreductase activity" EXACT [EC:1.1.5.4] synonym: "(S)-malate:quinone oxidoreductase activity" EXACT [EC:1.1.5.4] synonym: "FAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.5.4] synonym: "MQO activity" BROAD [EC:1.1.5.4] xref: EC:1.1.5.4 xref: MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0008925 name: maltose O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79] subset: gosubset_prok synonym: "acetyl-CoA:maltose O-acetyltransferase activity" EXACT [EC:2.3.1.79] synonym: "maltose transacetylase activity" EXACT [EC:2.3.1.79] xref: EC:2.3.1.79 xref: MetaCyc:MALTACETYLTRAN-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008926 name: mannitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17] subset: gosubset_prok xref: EC:1.1.1.17 xref: MetaCyc:MANNPDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008927 name: mannonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.8, RHEA:20100] subset: gosubset_prok synonym: "altronate hydrolase activity" EXACT [EC:4.2.1.8] synonym: "altronic hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonic hydrolase activity" EXACT [EC:4.2.1.8] xref: EC:4.2.1.8 xref: KEGG:R05606 xref: MetaCyc:MANNONDEHYDRAT-RXN xref: RHEA:20100 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008928 name: mannose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate." [EC:2.7.7.22, RHEA:12908] subset: gosubset_prok synonym: "GDP mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22] synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "guanosine diphosphomannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] xref: EC:2.7.7.22 xref: KEGG:R00883 xref: MetaCyc:MANNPGUANYLTRANGDP-RXN xref: RHEA:12908 is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0008929 name: methylglyoxal synthase activity namespace: molecular_function def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3, RHEA:17940] subset: gosubset_prok synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" EXACT [EC:4.2.3.3] synonym: "glycerone-phosphate phospho-lyase activity" EXACT [EC:4.2.3.3] synonym: "methylglyoxal synthetase activity" EXACT [EC:4.2.3.3] xref: EC:4.2.3.3 xref: KEGG:R01016 xref: MetaCyc:METHGLYSYN-RXN xref: RHEA:17940 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0008930 name: methylthioadenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16] subset: gosubset_prok synonym: "5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "MeSAdo nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "methylthioadenosine methylthioribohydrolase activity" EXACT [EC:3.2.2.16] synonym: "MTA nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" EXACT [EC:3.2.2.16] xref: EC:3.2.2.16 xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN is_a: GO:0008477 ! purine nucleosidase activity [Term] id: GO:0008931 name: murein DD-endopeptidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008932 name: lytic endotransglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199] synonym: "murein lytic endotransglycosylase E activity" NARROW [] xref: EC:2.4.99.- is_a: GO:0008933 ! lytic transglycosylase activity [Term] id: GO:0008933 name: lytic transglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424] subset: gosubset_prok synonym: "murein transglycosylase B activity" NARROW [] synonym: "peptidoglycan lytic transglycosylase activity" EXACT [] xref: EC:3.2.1.- is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008934 name: inositol-1(or 4)-monophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] subset: gosubset_prok synonym: "inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "inositol monophosphate phosphatase activity" BROAD [EC:3.1.3.25] synonym: "inositol phosphatase activity" BROAD [EC:3.1.3.25] synonym: "inositol-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "L-myo-inositol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol monophosphatase activity" BROAD [EC:3.1.3.25] synonym: "myo-inositol-1(or 4)-monophosphatase activity" EXACT [] synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] xref: EC:3.1.3.25 xref: MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN xref: Reactome:1702 "inositol-1(or 4)-monophosphatase activity" is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0008935 name: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA." [EC:4.1.3.36] subset: gosubset_prok synonym: "1,4-dihydroxy-2-naphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "DHNA synthetase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoic acid synthetase activity" EXACT [EC:4.1.3.36] synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" EXACT [EC:4.1.3.36] synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing; CoA-forming)" EXACT [EC:4.1.3.36] synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase activity" RELATED [KEGG:R04150] xref: EC:4.1.3.36 xref: KEGG:R04150 xref: MetaCyc:NAPHTHOATE-SYN-RXN xref: RHEA:15528 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008936 name: nicotinamidase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19] subset: gosubset_prok synonym: "NAMase activity" EXACT [EC:3.5.1.19] synonym: "namase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidohydrolase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide deaminase activity" EXACT [EC:3.5.1.19] synonym: "nicotine deamidase activity" EXACT [EC:3.5.1.19] synonym: "YNDase activity" EXACT [EC:3.5.1.19] xref: EC:3.5.1.19 xref: MetaCyc:NICOTINAMID-RXN xref: Reactome:1714 "nicotinamidase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008937 name: ferredoxin-NAD(P) reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [EC:1.18.1.-] subset: gosubset_prok synonym: "ferredoxin reductase activity" BROAD [] xref: EC:1.18.1.- is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0008938 name: nicotinate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine." [EC:2.1.1.7, RHEA:20244] synonym: "furanocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.7] synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" EXACT [EC:2.1.1.7] xref: EC:2.1.1.7 xref: KEGG:R01721 xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN xref: RHEA:20244 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008939 name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate." [EC:2.4.2.21, RHEA:11199] subset: gosubset_prok synonym: "CobT" RELATED [EC:2.4.2.21] synonym: "N(1)-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "N1-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] xref: EC:2.4.2.21 xref: KEGG:R04148 xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN xref: RHEA:11199 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0008940 name: nitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor." [EC:1.7.99.4] subset: gosubset_prok synonym: "nitrate reductase (acceptor)" EXACT [EC:1.7.99.4] synonym: "nitrite:(acceptor) oxidoreductase" EXACT [EC:1.7.99.4] synonym: "nitrite:acceptor oxidoreductase" EXACT [EC:1.7.99.4] synonym: "respiratory nitrate reductase activity" NARROW [EC:1.7.99.4] xref: EC:1.7.99.4 xref: MetaCyc:NITRATREDUCT-RXN is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0008941 name: nitric oxide dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+." [EC:1.14.12.17] subset: gosubset_prok synonym: "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.12.17] synonym: "NOD activity" EXACT [EC:1.14.12.17] xref: EC:1.14.12.17 xref: MetaCyc:R621-RXN is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0008942 name: nitrite reductase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+." [EC:1.7.1.4] comment: Note that this function was formerly EC:1.6.6.4. subset: gosubset_prok synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4] synonym: "NAD(P)H2:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NAD(P)H:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADH-nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADPH-nitrite reductase activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4] xref: EC:1.7.1.4 xref: MetaCyc:NITRITREDUCT-RXN is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0008943 name: glyceraldehyde-3-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reactions: glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl-phosphate + NAD(P)H + H+, and glyceraldehyde 3-phosphate + H2O + NAD(P)+ = 3-phospho-D-glycerate + NAD(P)H + H+." [EC:1.2.1.12, EC:1.2.1.13, EC:1.2.1.9] comment: Note that the reaction with phosphate as a substrate produces 3-phospho-D-glyceroyl-phosphate. subset: gosubset_prok xref: EC:1.2.1.- is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008944 name: oligopeptidase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [EC:3.4.24.70] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70] xref: EC:3.4.24.70 xref: MetaCyc:3.4.24.70-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008945 name: oligopeptidase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [EC:3.4.21.83] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83] synonym: "protease II activity" EXACT [EC:3.4.21.83] xref: EC:3.4.21.83 xref: MetaCyc:3.4.21.83-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008946 name: oligonucleotidase activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." [EC:3.1.13.3] comment: Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP. subset: gosubset_prok xref: EC:3.1.13.3 xref: MetaCyc:3.1.13.3-RXN is_a: GO:0004518 ! nuclease activity [Term] id: GO:0008947 name: omptin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok xref: EC:3.4.21.87 xref: MetaCyc:3.4.21.87-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008948 name: oxaloacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate = pyruvate + CO2." [EC:4.1.1.3] subset: gosubset_prok synonym: "oxalacetic acid decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxalate beta-decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxaloacetate beta-decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.3] synonym: "oxaloacetate carboxy-lyase activity" EXACT [EC:4.1.1.3] xref: EC:4.1.1.3 xref: MetaCyc:OXALODECARB-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008949 name: oxalyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA." [EC:4.1.1.8, RHEA:19336] subset: gosubset_prok synonym: "oxalyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.8] xref: EC:4.1.1.8 xref: KEGG:R01908 xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN xref: RHEA:19336 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008950 name: p-aminobenzoate synthetase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. is_obsolete: true consider: GO:0008696 consider: GO:0046820 [Term] id: GO:0008951 name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]." [MetaCyc:PALMITOTRANS-RXN] synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT [] xref: EC:2.3.1.- xref: MetaCyc:PALMITOTRANS-RXN is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0008953 name: penicillin amidase activity namespace: molecular_function def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11] subset: gosubset_prok synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" EXACT [EC:3.5.1.11] synonym: "ampicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "benzylpenicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "novozym 217" RELATED [EC:3.5.1.11] synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT [] synonym: "penicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "penicillin amidohydrolase activity" EXACT [EC:3.5.1.11] synonym: "semacylase activity" EXACT [EC:3.5.1.11] xref: EC:3.5.1.11 xref: MetaCyc:PENICILLIN-AMIDASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008954 name: peptidoglycan synthetase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it was not defined, is ambiguous, and has been used to annotate gene products with very different activities. subset: gosubset_prok is_obsolete: true consider: GO:0008955 consider: GO:0071972 [Term] id: GO:0008955 name: peptidoglycan glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate." [EC:2.4.1.129] subset: gosubset_prok synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.129] synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.1.129] synonym: "peptidoglycan TGase activity" EXACT [EC:2.4.1.129] synonym: "peptidoglycan transglycosylase activity" EXACT [EC:2.4.1.129] synonym: "PG-II activity" EXACT [EC:2.4.1.129] synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129] xref: EC:2.4.1.129 xref: MetaCyc:RXN0-5405 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008956 name: peptidyl-dipeptidase Dcp activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "dipeptidyl carboxypeptidase (Dcp)" EXACT [EC:3.4.15.5] synonym: "dipeptidyl carboxypeptidase activity" EXACT [EC:3.4.15.5] xref: EC:3.4.15.5 xref: MetaCyc:3.4.15.5-RXN is_obsolete: true replaced_by: GO:0008235 replaced_by: GO:0008241 [Term] id: GO:0008957 name: phenylacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+." [EC:1.2.1.39] subset: gosubset_prok synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.39] xref: EC:1.2.1.39 xref: MetaCyc:PHENDEHYD-RXN xref: UM-BBD_reactionID:r0035 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008959 name: phosphate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8] subset: gosubset_prok synonym: "acetyl-CoA:phosphate acetyltransferase activity" EXACT [EC:2.3.1.8] synonym: "phosphoacylase activity" EXACT [EC:2.3.1.8] synonym: "phosphotransacetylase activity" EXACT [EC:2.3.1.8] synonym: "PTA" RELATED [EC:2.3.1.8] xref: EC:2.3.1.8 xref: MetaCyc:PHOSACETYLTRANS-RXN is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0008960 name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20] subset: gosubset_prok synonym: "oligosaccharide glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20] synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20] xref: EC:2.7.8.20 xref: MetaCyc:PGLYCEROLTRANSI-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008961 name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity namespace: molecular_function def: "Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein." [PMID:8051048] subset: gosubset_prok is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008962 name: phosphatidylglycerophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [EC:3.1.3.27] subset: gosubset_prok synonym: "PGP phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphate phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerophosphate phosphohydrolase activity" EXACT [EC:3.1.3.27] xref: EC:3.1.3.27 xref: MetaCyc:PGPPHOSPHA-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008963 name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13] comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. subset: gosubset_prok synonym: "MraY transferase activity" NARROW [EC:2.7.8.13] synonym: "phospho-MurNAc-pentapeptide transferase activity" EXACT [EC:2.7.8.13] synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13] xref: EC:2.7.8.13 xref: MetaCyc:RXN-8975 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008964 name: phosphoenolpyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + oxaloacetate + phosphate = CO(2) + H(2)O + phosphoenolpyruvate." [EC:4.1.1.31, RHEA:23075] subset: gosubset_prok synonym: "PEP carboxylase activity" EXACT [EC:4.1.1.31] synonym: "PEPC" RELATED [EC:4.1.1.31] synonym: "PEPCase activity" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" EXACT [EC:4.1.1.31] synonym: "phosphoenolpyruvic carboxylase activity" EXACT [EC:4.1.1.31] synonym: "phosphopyruvate (phosphate) carboxylase activity" EXACT [EC:4.1.1.31] xref: EC:4.1.1.31 xref: KEGG:R00345 xref: MetaCyc:PEPCARBOX-RXN xref: RHEA:23075 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0008965 name: phosphoenolpyruvate-protein phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9] subset: gosubset_prok synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9] synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate--protein phosphatase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein factor phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9] xref: EC:2.7.3.9 xref: MetaCyc:2.7.3.9-RXN is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0008966 name: phosphoglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10, RHEA:23427] subset: gosubset_prok synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] synonym: "D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] xref: EC:5.4.2.10 xref: KEGG:R02060 xref: MetaCyc:5.4.2.10-RXN xref: RHEA:23427 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008967 name: phosphoglycolate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14372] subset: gosubset_prok synonym: "2-phosphoglycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "2-phosphoglycolate phosphohydrolase activity" EXACT [EC:3.1.3.18] synonym: "P-glycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycolate hydrolase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycollate phosphatase activity" EXACT [EC:3.1.3.18] xref: EC:3.1.3.18 xref: KEGG:R01334 xref: MetaCyc:GPH-RXN xref: RHEA:14372 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008968 name: D-sedoheptulose 7-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969] subset: gosubset_prok synonym: "phosphoheptose isomerase activity" EXACT [] xref: MetaCyc:RXN0-4301 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008969 name: phosphohistidine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate." [GOC:mah] subset: gosubset_prok xref: EC:3.1.3.- is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008970 name: phospholipase A1 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] subset: gosubset_prok synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT [EC:3.1.1.32] xref: EC:3.1.1.32 xref: MetaCyc:PHOSPHOLIPASE-A1-RXN is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0008972 name: phosphomethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7] subset: gosubset_prok synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" EXACT [EC:2.7.4.7] synonym: "hydroxymethylpyrimidine phosphokinase activity" EXACT [EC:2.7.4.7] xref: EC:2.7.4.7 xref: MetaCyc:PYRIMSYN3-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0008973 name: phosphopentomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7] subset: gosubset_prok synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.7] synonym: "alpha-D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphoribomutase activity" EXACT [EC:5.4.2.7] xref: EC:5.4.2.7 xref: MetaCyc:PPENTOMUT-RXN is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008974 name: phosphoribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.19, RHEA:19368] subset: gosubset_prok synonym: "5-phosphoribulose kinase activity" EXACT [EC:2.7.1.19] synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.19] synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19] synonym: "phosphoribulokinase (phosphorylating)" EXACT [EC:2.7.1.19] synonym: "PKK" RELATED [EC:2.7.1.19] synonym: "PRK" RELATED [EC:2.7.1.19] synonym: "PRuK" RELATED [EC:2.7.1.19] synonym: "ribulose phosphate kinase activity" EXACT [EC:2.7.1.19] synonym: "ribulose-5-phosphate kinase activity" EXACT [EC:2.7.1.19] xref: EC:2.7.1.19 xref: KEGG:R01523 xref: MetaCyc:PHOSPHORIBULOKINASE-RXN xref: RHEA:19368 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008975 name: pitrilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [EC:3.4.24.55] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "Escherichia coli metalloproteinase Pi" RELATED [EC:3.4.24.55] synonym: "Escherichia coli protease III" RELATED [EC:3.4.24.55] synonym: "protease III activity" EXACT [EC:3.4.24.55] synonym: "protease Pi activity" EXACT [EC:3.4.24.55] synonym: "proteinase Pi" RELATED [EC:3.4.24.55] synonym: "PTR" RELATED [EC:3.4.24.55] xref: EC:3.4.24.55 xref: MetaCyc:3.4.24.55-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008976 name: polyphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1] subset: gosubset_prok synonym: "ATP-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "ATP:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "polyphosphate polymerase activity" EXACT [GOC:curators] synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1] xref: EC:2.7.4.1 xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0008977 name: prephenate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH." [EC:1.3.1.12, RHEA:13872] subset: gosubset_prok synonym: "chorismate mutase--prephenate dehydrogenase activity" EXACT [EC:1.3.1.12] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12] synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.12] xref: EC:1.3.1.12 xref: KEGG:R01728 xref: MetaCyc:PREPHENATEDEHYDROG-RXN xref: RHEA:13872 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008978 name: prepilin peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok xref: EC:3.4.23.43 xref: MetaCyc:3.4.23.43-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0008979 name: prophage integrase activity namespace: molecular_function def: "Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome." [GOC:mah] subset: gosubset_prok is_a: GO:0008907 ! integrase activity [Term] id: GO:0008980 name: propionate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate." [EC:2.7.2.15] subset: gosubset_prok synonym: "ATP:propanoate phosphotransferase activity" EXACT [] synonym: "PduW" RELATED [] synonym: "propanoate kinase activity" EXACT [] synonym: "TdcD" RELATED [] xref: EC:2.7.2.15 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008981 name: protease IV activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008982 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity namespace: molecular_function alt_id: GO:0015455 alt_id: GO:0015456 def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-] subset: gosubset_prok synonym: "enzyme II of the phosphotransferase system" NARROW [EC:2.7.1.69] synonym: "enzyme IIl4ac" RELATED [EC:2.7.1.69] synonym: "gene bglC RNA formation factors" RELATED [EC:2.7.1.69] synonym: "gene glC proteins" RELATED [EC:2.7.1.69] synonym: "group translocator activity" RELATED [EC:2.7.1.69] synonym: "PEP--sugar phosphotransferase enzyme II activity" NARROW [EC:2.7.1.69] synonym: "PEP-dependent phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphoribosyltransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphoprotein factor-hexose phosophotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphotransfer-driven group translocator" EXACT [] synonym: "phosphotransferase, phosphohistidinoprotein-hexose activity" EXACT [EC:2.7.1.69] synonym: "protein, specific or class, gene bglC" RELATED [EC:2.7.1.69] synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT [] synonym: "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine-sugar phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "PTS permease activity" EXACT [EC:2.7.1.69] synonym: "PTS transporter" RELATED [EC:2.7.1.69] synonym: "ribonucleic acid formation factor, gene glC" RELATED [EC:2.7.1.69] synonym: "sucrose phosphotransferase system II" RELATED [EC:2.7.1.69] xref: EC:2.7.1.69 xref: MetaCyc:2.7.1.69-RXN is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0008983 name: protein-glutamate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80, RESID:AA0072] subset: gosubset_prok synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80] synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80] synonym: "protein carboxyl-methylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxyl-O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80] synonym: "protein carboxymethylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxymethyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein methylase II" RELATED [EC:2.1.1.80] synonym: "protein O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(aspartate)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(carboxyl)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EXACT [EC:2.1.1.80] xref: EC:2.1.1.80 xref: MetaCyc:CHER-RXN xref: RESID:AA0072 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0008984 name: protein-glutamate methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072] subset: gosubset_prok synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61] synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61] synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61] synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61] synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] xref: EC:3.1.1.61 xref: MetaCyc:MCPMETEST-RXN xref: RESID:AA0072 is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0008985 name: pyruvate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2] subset: gosubset_prok synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.2] synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" EXACT [EC:1.2.2.2] synonym: "pyruvic (cytochrome b1) dehydrogenase activity" EXACT [EC:1.2.2.2] xref: EC:1.2.2.2 xref: MetaCyc:PYRUVOXID-RXN is_a: GO:0004738 ! pyruvate dehydrogenase activity is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0008986 name: pyruvate, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate." [EC:2.7.9.2, RHEA:11367] subset: gosubset_prok synonym: "ATP:pyruvate, water phosphotransferase activity" EXACT [EC:2.7.9.2] synonym: "PEP synthase activity" EXACT [] synonym: "PEP synthetase activity" EXACT [EC:2.7.9.2] synonym: "phoephoenolpyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvate synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvic synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphopyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate,water dikinase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate-water dikinase (phosphorylating)" EXACT [EC:2.7.9.2] synonym: "water pyruvate dikinase activity" EXACT [] xref: EC:2.7.9.2 xref: KEGG:R00199 xref: MetaCyc:PEPSYNTH-RXN xref: RHEA:11367 is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0008987 name: quinolinate synthetase A activity namespace: molecular_function def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN] subset: gosubset_prok xref: MetaCyc:QUINOLINATE-SYNTHA-RXN is_a: GO:0003824 ! catalytic activity [Term] id: GO:0008988 name: rRNA (adenine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [EC:2.1.1.48] subset: gosubset_prok synonym: "ErmC 23S rRNA methyltransferase" NARROW [EC:2.1.1.48] synonym: "gene ksgA methyltransferase" NARROW [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N(6)) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N6) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.48] xref: EC:2.1.1.48 xref: MetaCyc:RRNA-ADENINE-N6--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0008989 name: rRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [EC:2.1.1.51] subset: gosubset_prok synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.51] synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.51] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.51] xref: EC:2.1.1.51 xref: MetaCyc:RRNA-GUANINE-N1--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0008990 name: rRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [EC:2.1.1.52] subset: gosubset_prok synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.52] xref: EC:2.1.1.52 xref: MetaCyc:RRNA-GUANINE-N2--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0008991 name: serine-type signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. xref: EC:3.4.21.- is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008992 name: repressor LexA activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [EC:3.4.21.88] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "LexA repressor" RELATED [EC:3.4.21.88] synonym: "repressor lexA" RELATED [EC:3.4.21.88] xref: EC:3.4.21.88 xref: MetaCyc:3.4.21.88-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008993 name: rhamnulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5] subset: gosubset_prok synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulokinase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "rhamnulokinase (phosphorylating)" EXACT [EC:2.7.1.5] synonym: "rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "RhuK" RELATED [EC:2.7.1.5] xref: EC:2.7.1.5 xref: MetaCyc:RHAMNULOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008994 name: rhamnulose-1-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19] subset: gosubset_prok synonym: "L-rhamnulose 1-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "rhamnulose phosphate aldolase activity" EXACT [EC:4.1.2.19] xref: EC:4.1.2.19 xref: MetaCyc:RHAMNULPALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008995 name: ribonuclease E activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] subset: gosubset_prok xref: MetaCyc:3.1.26.12-RXN is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008996 name: ribonuclease G activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] subset: gosubset_prok is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008997 name: ribonuclease R activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193] subset: gosubset_prok xref: EC:3.1.11.- is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008998 name: ribonucleoside-triphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin." [EC:1.17.4.2] subset: gosubset_prok synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2] xref: EC:1.17.4.2 xref: MetaCyc:1.17.4.2-RXN is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [Term] id: GO:0008999 name: ribosomal-protein-alanine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine." [EC:2.3.1.128] subset: gosubset_prok synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" EXACT [EC:2.3.1.128] synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128] xref: EC:2.3.1.128 xref: MetaCyc:2.3.1.128-RXN is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity [Term] id: GO:0009000 name: selenocysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16] subset: gosubset_prok synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" EXACT [EC:4.4.1.16] synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16] synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16] xref: EC:4.4.1.16 xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0009001 name: serine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA." [EC:2.3.1.30, RHEA:24563] subset: gosubset_prok synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "L-serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "SATase activity" EXACT [EC:2.3.1.30] synonym: "serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "serine transacetylase activity" EXACT [EC:2.3.1.30] xref: EC:2.3.1.30 xref: KEGG:R00586 xref: MetaCyc:SERINE-O-ACETTRAN-RXN xref: Reactome:24320 "serine O-acetyltransferase activity" xref: RHEA:24563 is_a: GO:0016412 ! serine O-acyltransferase activity is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0009002 name: serine-type D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4] subset: gosubset_prok synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "D-alanyl carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving peptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "DD-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-transpeptidase activity" EXACT [EC:3.4.16.4] xref: EC:3.4.16.4 xref: MetaCyc:3.4.16.4-RXN is_a: GO:0004185 ! serine-type carboxypeptidase activity [Term] id: GO:0009003 name: signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. is_obsolete: true replaced_by: GO:0008233 [Term] id: GO:0009004 name: signal peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [EC:3.4.21.89] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "bacterial leader peptidase 1" RELATED [EC:3.4.21.89] synonym: "bacterial leader peptidase I activity" NARROW [EC:3.4.21.89] synonym: "Escherichia coli leader peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "HOSP" RELATED [EC:3.4.21.89] synonym: "leader peptidase activity" EXACT [EC:3.4.21.89] synonym: "leader peptidase I" RELATED [EC:3.4.21.89] synonym: "leader peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "leader proteinase activity" EXACT [EC:3.4.21.89] synonym: "phage-procoat-leader peptidase activity" NARROW [EC:3.4.21.89] synonym: "pilin leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "propeptidase activity" EXACT [EC:3.4.21.89] synonym: "PuIO prepilin peptidase" NARROW [EC:3.4.21.89] synonym: "signal peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "signal proteinase activity" EXACT [EC:3.4.21.89] synonym: "signalase activity" EXACT [EC:3.4.21.89] synonym: "SPase I activity" EXACT [EC:3.4.21.89] synonym: "SPC" RELATED [EC:3.4.21.89] xref: EC:3.4.21.89 xref: MetaCyc:3.4.21.89-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0009005 name: signal peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "leader peptidase II" RELATED [EC:3.4.23.36] synonym: "lipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "premurein leader proteinase activity" EXACT [EC:3.4.23.36] synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36] synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "SPase II activity" EXACT [EC:3.4.23.36] xref: EC:3.4.23.36 xref: MetaCyc:3.4.23.36-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0009006 name: siroheme synthase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents three different molecular functions. synonym: "sirohaem synthase activity" EXACT [] is_obsolete: true consider: GO:0004851 consider: GO:0019354 consider: GO:0043115 consider: GO:0051266 [Term] id: GO:0009007 name: site-specific DNA-methyltransferase (adenine-specific) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72] subset: gosubset_prok synonym: "DNA adenine methylase" BROAD [] synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72] synonym: "modification methylase activity" RELATED [EC:2.1.1.72] synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72] xref: EC:2.1.1.72 xref: MetaCyc:2.1.1.72-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity [Term] id: GO:0009008 name: DNA-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleate methylase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleate methyltransferase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleic acid methylase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleic acid methyltransferase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleic acid modification methylase activity" RELATED [EC:2.1.1.-] synonym: "DNA methylase" BROAD [] synonym: "DNA methyltransferase activity" EXACT [] synonym: "DNA transmethylase activity" EXACT [EC:2.1.1.-] synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37] xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0009009 name: site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences." [GOC:elh] comment: Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds. subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0009010 name: sorbitol-6-phosphate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140] subset: gosubset_prok synonym: "D-glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.140] synonym: "glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "ketosephosphate reductase activity" EXACT [EC:1.1.1.140] synonym: "sorbitol-6-P-dehydrogenase activity" EXACT [EC:1.1.1.140] xref: EC:1.1.1.140 xref: MetaCyc:SORB6PDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009011 name: starch synthase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21] subset: gosubset_prok synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21] synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21] synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21] synonym: "starch synthetase activity" EXACT [EC:2.4.1.21] xref: EC:2.4.1.21 xref: MetaCyc:GLYCOGENSYN-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0009012 name: aminoglycoside 3''-adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H(+)." [EC:2.7.7.47, RHEA:20248] subset: gosubset_prok synonym: "AAD (3'')" RELATED [EC:2.7.7.47] synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW [] synonym: "streptomycin 3''-adenylyltransferase activity" NARROW [] xref: EC:2.7.7.47 xref: KEGG:R02226 xref: MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN xref: RHEA:20248 is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity [Term] id: GO:0009013 name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16] subset: gosubset_prok synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.2.1.16] synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.16] xref: EC:1.2.1.16 xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN xref: UM-BBD_reactionID:r0371 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0009014 name: succinyl-diaminopimelate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate." [EC:3.5.1.18, RHEA:22611] subset: gosubset_prok synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.18] synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.18] xref: EC:3.5.1.18 xref: KEGG:R02734 xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN xref: RHEA:22611 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009015 name: N-succinylarginine dihydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H(2)O + 2 H(+) = N(2)-succinyl-L-ornithine + CO(2) + 2 NH(4)(+)." [EC:3.5.3.23, RHEA:19536] subset: gosubset_prok synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [EC:3.5.3.23] synonym: "arginine succinylhydrolase activity" EXACT [] synonym: "AruB" RELATED [] synonym: "AstB" RELATED [] synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [] synonym: "N2-succinylarginine dihydrolase activity" EXACT [] synonym: "SADH" RELATED [] synonym: "succinylarginine dihydrolase activity" EXACT [] xref: EC:3.5.3.23 xref: KEGG:R04189 xref: MetaCyc:SUCCARGDIHYDRO-RXN xref: RHEA:19536 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0009016 name: succinyldiaminopimelate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate." [EC:2.6.1.17, RHEA:11963] subset: gosubset_prok synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.17] synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" EXACT [EC:2.6.1.17] synonym: "succinyldiaminopimelate aminotransferase activity" EXACT [] synonym: "succinyldiaminopimelate transferase activity" EXACT [EC:2.6.1.17] xref: EC:2.6.1.17 xref: KEGG:R04475 xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN xref: RHEA:11963 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0009017 name: succinylglutamate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-glutamate + H(2)O = L-glutamate + succinate." [EC:3.5.1.96, RHEA:15172] subset: gosubset_prok synonym: "AstE" RELATED [] synonym: "N-succinyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.96] synonym: "N2-succinylglutamate desuccinylase activity" EXACT [] synonym: "SGDS" RELATED [] xref: EC:3.5.1.96 xref: KEGG:R00411 xref: MetaCyc:SUCCGLUDESUCC-RXN xref: RHEA:15172 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009018 name: sucrose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [EC:2.4.1.7] subset: gosubset_prok synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7] synonym: "sucrose glucosyltransferase activity" EXACT [EC:2.4.1.7] synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.7] xref: EC:2.4.1.7 xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0009019 name: tRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "transfer ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "tRNA guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] xref: EC:2.1.1.31 xref: MetaCyc:TRNA-GUANINE-N1--METHYLTRANSFERASE-RXN is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0009020 name: tRNA (guanosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "transfer ribonucleate guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) 2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (guanosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] xref: EC:2.1.1.34 xref: MetaCyc:2.1.1.34-RXN is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0009021 name: tRNA (uracil-5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine." [EC:2.1.1.35] subset: gosubset_prok synonym: "m5U-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "M5U-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35] synonym: "RUMT activity" EXACT [EC:2.1.1.35] synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil methylase activity" EXACT [EC:2.1.1.35] synonym: "tRNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35] xref: EC:2.1.1.35 xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity [Term] id: GO:0009022 name: tRNA nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56] comment: Note that, although the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. subset: gosubset_prok synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56] synonym: "ribonuclease PH activity" EXACT [EC:2.7.7.56] synonym: "RNase PH activity" EXACT [EC:2.7.7.56] synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56] xref: EC:2.7.7.56 xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0009023 name: tRNA sulfurtransferase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4, GOC:go_curators] synonym: "tRNA sulphurtransferase activity" EXACT [] is_obsolete: true replaced_by: GO:0034227 consider: GO:0016783 [Term] id: GO:0009024 name: tagatose-6-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144] subset: gosubset_prok synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.144] synonym: "phosphotagatokinase activity" EXACT [EC:2.7.1.144] xref: EC:2.7.1.144 xref: MetaCyc:TAGAKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009025 name: tagatose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate." [EC:4.1.2.40, RHEA:22951] subset: gosubset_prok synonym: "AgaY" RELATED [] synonym: "AgaZ" RELATED [] synonym: "D-tagatose-1,6-bisphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT [] synonym: "D-tagatose-1xxx,6-bisphosphate triosephosphate lyase activity" EXACT [EC:4.1.2.40] synonym: "KbaY" RELATED [] synonym: "tagatose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT [] xref: EC:4.1.2.40 xref: KEGG:R01069 xref: MetaCyc:TAGAALDOL-RXN xref: RHEA:22951 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0009026 name: tagaturonate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH." [EC:1.1.1.58, RHEA:17816] subset: gosubset_prok synonym: "altronate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "altronate oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "altronic oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-altronate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-tagaturonate reductase activity" EXACT [EC:1.1.1.58] synonym: "tagaturonate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "TagUAR" RELATED [EC:1.1.1.58] xref: EC:1.1.1.58 xref: KEGG:R02555 xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN xref: RHEA:17816 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009027 name: tartrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93] subset: gosubset_prok synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93] synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93] xref: EC:1.1.1.93 xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009028 name: tartronate-semialdehyde synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2)." [EC:4.1.1.47, RHEA:10139] subset: gosubset_prok synonym: "glyoxalate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.47] synonym: "glyoxylic carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "hydroxymalonic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronate semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] xref: EC:4.1.1.47 xref: KEGG:R00013 xref: MetaCyc:GLYOCARBOLIG-RXN xref: RHEA:10139 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0009029 name: tetraacyldisaccharide 4'-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H(+) + lipid IV(a)." [EC:2.7.1.130, RHEA:20703] subset: gosubset_prok synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" EXACT [EC:2.7.1.130] synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130] xref: EC:2.7.1.130 xref: KEGG:R04657 xref: MetaCyc:TETRAACYLDISACC4KIN-RXN xref: RHEA:20703 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009030 name: thiamine-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine phosphate = ADP + H(+) + thiamine diphosphate." [EC:2.7.4.16, RHEA:15916] subset: gosubset_prok synonym: "ATP:thiamine-phosphate phosphotransferase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphatase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphokinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin phosphate kinase activity" EXACT [GOC:curators] synonym: "thiamin-monophosphate kinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin-phosphate kinase activity" EXACT [] synonym: "thiamine-monophosphate kinase activity" EXACT [EC:2.7.4.16] xref: EC:2.7.4.16 xref: KEGG:R00617 xref: MetaCyc:THI-P-KIN-RXN xref: RHEA:15916 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0009032 name: thymidine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [EC:2.4.2.4] subset: gosubset_prok synonym: "animal growth regulators, blood platelet-derived endothelial cell growth factors" RELATED [EC:2.4.2.4] synonym: "blood platelet-derived endothelial cell growth factor" RELATED [EC:2.4.2.4] synonym: "deoxythymidine phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "gliostatins" RELATED [EC:2.4.2.4] synonym: "pyrimidine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4] synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] xref: EC:2.4.2.4 xref: MetaCyc:THYM-PHOSPH-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0009033 name: trimethylamine-N-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [EC:1.6.6.9] subset: gosubset_prok synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT [EC:1.6.6.9] synonym: "trimethylamine N-oxide reductase" EXACT [EC:1.6.6.9] synonym: "trimethylamine oxidase activity" EXACT [EC:1.6.6.9] synonym: "trimethylamine oxide reductase" EXACT [EC:1.6.6.9] xref: EC:1.6.6.9 xref: MetaCyc:TMAOREDUCT-RXN is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0009034 name: tryptophanase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + H(2)O = indole + NH(4)(+) + pyruvate." [EC:4.1.99.1, RHEA:19556] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. subset: gosubset_prok synonym: "L-tryptophan indole-lyase (deaminating) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophanase activity" EXACT [EC:4.1.99.1] synonym: "TNase activity" EXACT [EC:4.1.99.1] synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1] synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1] xref: EC:4.1.99.1 xref: KEGG:R00673 xref: MetaCyc:TRYPDEG-PWY xref: MetaCyc:TRYPTOPHAN-RXN xref: RHEA:19556 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0009035 name: Type I site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [EC:3.1.21.3, PMID:15788748] subset: gosubset_prok synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" EXACT [EC:3.1.21.3] synonym: "ATP-dependent DNase activity" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" EXACT [EC:3.1.21.3] synonym: "Type I restriction enzyme activity" EXACT [] synonym: "type I site-specific deoxyribonuclease activity" EXACT [EC:3.1.21.3] xref: EC:3.1.21.3 xref: MetaCyc:3.1.21.3-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0009036 name: Type II site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995] subset: gosubset_prok synonym: "Type II restriction enzyme activity" EXACT [] xref: EC:3.1.21.4 xref: MetaCyc:3.1.21.4-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0009037 name: tyrosine-based site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626] subset: gosubset_prok synonym: "site-specific tyrosine recombinase activity" EXACT [] synonym: "tyrosine recombinase" BROAD [] is_a: GO:0008907 ! integrase activity is_a: GO:0009009 ! site-specific recombinase activity [Term] id: GO:0009038 name: undecaprenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + undecaprenol = all-trans-undecaprenyl phosphate + ADP + 2 H(+)." [EC:2.7.1.66, RHEA:23755] subset: gosubset_prok synonym: "ATP:undecaprenol phosphotransferase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenyl alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase (phosphorylating)" BROAD [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase activity" BROAD [EC:2.7.1.66] synonym: "isoprenoid alcohol phosphokinase activity" BROAD [EC:2.7.1.66] synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66] synonym: "polyisoprenol kinase activity" BROAD [EC:2.7.1.66] xref: EC:2.7.1.66 xref: KEGG:R05626 xref: MetaCyc:UNDECAPRENOL-KINASE-RXN xref: RHEA:23755 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009039 name: urease activity namespace: molecular_function def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5] subset: gosubset_prok synonym: "urea amidohydrolase activity" EXACT [EC:3.5.1.5] xref: EC:3.5.1.5 xref: MetaCyc:UREASE-RXN xref: UM-BBD_reactionID:r0120 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009040 name: ureidoglycolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate + NADP+ = oxalureate + NADPH + H+." [EC:1.1.1.154] subset: gosubset_prok synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.154] xref: EC:1.1.1.154 xref: MetaCyc:R165-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009041 name: uridylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators] subset: gosubset_prok xref: EC:2.7.4.- is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0009042 name: valine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66, RHEA:22915] subset: gosubset_prok synonym: "alanine--valine transaminase activity" EXACT [EC:2.6.1.66] synonym: "alanine-oxoisovalerate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "L-valine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "transaminase C activity" NARROW [EC:2.6.1.66] synonym: "valine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "valine-pyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.66 xref: KEGG:R01215 xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN xref: RHEA:22915 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0009044 name: xylan 1,4-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37] subset: gosubset_prok synonym: "1,4-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.37] synonym: "beta-D-xylopyranosidase activity" EXACT [EC:3.2.1.37] synonym: "beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-D-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "xylobiase activity" EXACT [EC:3.2.1.37] xref: EC:3.2.1.37 xref: MetaCyc:3.2.1.37-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0009045 name: xylose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5] subset: gosubset_prok synonym: "D-xylose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketoisomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketol-isomerase activity" EXACT [EC:5.3.1.5] xref: EC:5.3.1.5 xref: MetaCyc:XYLISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0009046 name: zinc D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14] synonym: "D-alanyl-D-alanine hydrolase activity" EXACT [EC:3.4.17.14] synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" EXACT [EC:3.4.17.14] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14] synonym: "DD-carboxypeptidase-transpeptidase activity" EXACT [EC:3.4.17.14] synonym: "G enzyme" RELATED [EC:3.4.17.14] synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14] synonym: "Zn2+ G peptidase activity" EXACT [EC:3.4.17.14] xref: EC:3.4.17.14 xref: MetaCyc:3.4.17.14-RXN is_a: GO:0004181 ! metallocarboxypeptidase activity [Term] id: GO:0009047 name: dosage compensation, by hyperactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577] is_a: GO:0007549 ! dosage compensation [Term] id: GO:0009048 name: dosage compensation, by inactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, ISBN:0140512888, PMID:11498577] synonym: "Barr body formation" RELATED [] synonym: "chromosome inactivation" BROAD [] synonym: "X chromosome inactivation" EXACT [] xref: Wikipedia:X-inactivation is_a: GO:0007549 ! dosage compensation [Term] id: GO:0009049 name: aspartic-type signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. subset: gosubset_prok xref: EC:3.4.23.- is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0009050 name: glycopeptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycopeptides, any compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycopeptide breakdown" EXACT [] synonym: "glycopeptide catabolism" EXACT [] synonym: "glycopeptide degradation" EXACT [] is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0009051 name: pentose-phosphate shunt, oxidative branch namespace: biological_process def: "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:OXIDATIVEPENT-PWY] subset: gosubset_prok synonym: "oxidative branch, pentose pathway" EXACT [] synonym: "oxidative pentose phosphate pathway" EXACT [] synonym: "pentose phosphate pathway, oxidative branch" EXACT [] synonym: "pentose phosphate shunt, oxidative branch" EXACT [] synonym: "pentose-phosphate pathway, oxidative branch" EXACT [] xref: MetaCyc:OXIDATIVEPENT-PWY is_a: GO:0019321 ! pentose metabolic process relationship: part_of GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0009052 name: pentose-phosphate shunt, non-oxidative branch namespace: biological_process def: "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:NONOXIPENT-PWY] subset: gosubset_prok synonym: "pentose phosphate pathway, non-oxidative branch" EXACT [] synonym: "pentose phosphate shunt, non-oxidative branch" EXACT [] synonym: "pentose-phosphate pathway, non-oxidative branch" EXACT [] xref: MetaCyc:NONOXIPENT-PWY xref: MetaCyc:P21-PWY is_a: GO:0019321 ! pentose metabolic process relationship: part_of GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0009055 name: electron carrier activity namespace: molecular_function alt_id: GO:0009053 alt_id: GO:0009054 def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "2Fe-2S electron transfer carrier" NARROW [] synonym: "3Fe-4S/4Fe-4S electron transfer carrier" NARROW [] synonym: "adrenodoxin-type ferredoxin" NARROW [] synonym: "amicyanin" NARROW [] synonym: "azurin" NARROW [] synonym: "bacterial-type ferredoxin" NARROW [] synonym: "chloroplast-type ferredoxin" NARROW [] synonym: "copper electron carrier" NARROW [] synonym: "dicluster bacterial-type ferredoxin" NARROW [] synonym: "electron acceptor activity" NARROW [] synonym: "electron carrier, chlorophyll electron transport system" RELATED [] synonym: "electron donor activity" NARROW [] synonym: "electron transfer flavoprotein" NARROW [] synonym: "electron transfer flavoprotein, group I" NARROW [] synonym: "electron transfer flavoprotein, group II" NARROW [] synonym: "electron transporter activity" EXACT [] synonym: "high-potential iron-sulfur carrier" NARROW [] synonym: "iron-sulfur electron transfer carrier" NARROW [] synonym: "monocluster bacterial-type ferredoxin" NARROW [] synonym: "mononuclear iron electron carrier" NARROW [] synonym: "polyferredoxin" NARROW [] synonym: "redox-active disulfide bond electron carrier" NARROW [] synonym: "rubredoxin" NARROW [] synonym: "small blue copper electron carrier" NARROW [] synonym: "thioredoxin-like 2Fe-2S ferredoxin" NARROW [] xref: Reactome:20046 "electron carrier activity" is_a: GO:0003674 ! molecular_function [Term] id: GO:0009056 name: catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "breakdown" EXACT [] synonym: "catabolism" EXACT [] synonym: "degradation" EXACT [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0009057 name: macromolecule catabolic process namespace: biological_process alt_id: GO:0043285 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] subset: gosubset_prok synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule breakdown" EXACT [] synonym: "macromolecule catabolism" EXACT [] synonym: "macromolecule degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" EXACT [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] subset: gosubset_prok synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0009060 name: aerobic respiration namespace: biological_process def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:jl, ISBN:0140513590] subset: gosubset_prok xref: MetaCyc:PWY-3781 xref: Wikipedia:Cellular_respiration#Aerobic_respiration is_a: GO:0045333 ! cellular respiration [Term] id: GO:0009061 name: anaerobic respiration namespace: biological_process def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor." [GOC:jl, ISBN:0140513590] subset: gosubset_prok xref: MetaCyc:ANARESP1-PWY xref: Wikipedia:Anaerobic_respiration xref: Wikipedia:Cellular_respiration#Anaerobic_respiration is_a: GO:0045333 ! cellular respiration [Term] id: GO:0009062 name: fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] subset: gosubset_prok synonym: "fatty acid breakdown" EXACT [] synonym: "fatty acid catabolism" EXACT [] synonym: "fatty acid degradation" EXACT [] xref: Wikipedia:Fatty_acid_degradation is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0009063 name: cellular amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] subset: gosubset_prok synonym: "amino acid catabolic process" EXACT [GOC:curators] synonym: "cellular amino acid breakdown" EXACT [] synonym: "cellular amino acid catabolism" EXACT [] synonym: "cellular amino acid degradation" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0009310 ! amine catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0009064 name: glutamine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] subset: gosubset_prok synonym: "glutamine family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009065 name: glutamine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] subset: gosubset_prok synonym: "glutamine family amino acid breakdown" EXACT [] synonym: "glutamine family amino acid catabolism" EXACT [] synonym: "glutamine family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0009066 name: aspartate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] subset: gosubset_prok synonym: "aspartate family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009067 name: aspartate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] subset: gosubset_prok synonym: "aspartate family amino acid anabolism" EXACT [] synonym: "aspartate family amino acid biosynthesis" EXACT [] synonym: "aspartate family amino acid formation" EXACT [] synonym: "aspartate family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0009068 name: aspartate family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] subset: gosubset_prok synonym: "aspartate family amino acid breakdown" EXACT [] synonym: "aspartate family amino acid catabolism" EXACT [] synonym: "aspartate family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0009069 name: serine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] subset: gosubset_prok synonym: "serine family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009070 name: serine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] subset: gosubset_prok synonym: "serine family amino acid anabolism" EXACT [] synonym: "serine family amino acid biosynthesis" EXACT [] synonym: "serine family amino acid formation" EXACT [] synonym: "serine family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0009071 name: serine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] subset: gosubset_prok synonym: "serine family amino acid breakdown" EXACT [] synonym: "serine family amino acid catabolism" EXACT [] synonym: "serine family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0009072 name: aromatic amino acid family metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] subset: gosubset_prok synonym: "aromatic amino acid family metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process [Term] id: GO:0009073 name: aromatic amino acid family biosynthetic process namespace: biological_process alt_id: GO:0016089 def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] subset: gosubset_prok synonym: "aromatic amino acid family anabolism" EXACT [] synonym: "aromatic amino acid family biosynthesis" EXACT [] synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED [] synonym: "aromatic amino acid family formation" EXACT [] synonym: "aromatic amino acid family synthesis" EXACT [] xref: MetaCyc:COMPLETE-ARO-PWY is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0009074 name: aromatic amino acid family catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] subset: gosubset_prok synonym: "aromatic amino acid family breakdown" EXACT [] synonym: "aromatic amino acid family catabolism" EXACT [] synonym: "aromatic amino acid family degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0019439 ! aromatic compound catabolic process [Term] id: GO:0009075 name: histidine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the histidine family." [GOC:ai] subset: gosubset_prok synonym: "histidine family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009076 name: histidine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the histidine family." [GOC:ai] subset: gosubset_prok synonym: "histidine family amino acid anabolism" EXACT [] synonym: "histidine family amino acid biosynthesis" EXACT [] synonym: "histidine family amino acid formation" EXACT [] synonym: "histidine family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009075 ! histidine family amino acid metabolic process [Term] id: GO:0009077 name: histidine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family." [GOC:ai] subset: gosubset_prok synonym: "histidine family amino acid breakdown" EXACT [] synonym: "histidine family amino acid catabolism" EXACT [] synonym: "histidine family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009075 ! histidine family amino acid metabolic process [Term] id: GO:0009078 name: pyruvate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] subset: gosubset_prok synonym: "pyruvate family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009079 name: pyruvate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] subset: gosubset_prok synonym: "pyruvate family amino acid anabolism" EXACT [] synonym: "pyruvate family amino acid biosynthesis" EXACT [] synonym: "pyruvate family amino acid formation" EXACT [] synonym: "pyruvate family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009078 ! pyruvate family amino acid metabolic process [Term] id: GO:0009080 name: pyruvate family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] subset: gosubset_prok synonym: "pyruvate family amino acid breakdown" EXACT [] synonym: "pyruvate family amino acid catabolism" EXACT [] synonym: "pyruvate family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009078 ! pyruvate family amino acid metabolic process [Term] id: GO:0009081 name: branched chain family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] subset: gosubset_prok synonym: "branched chain family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009082 name: branched chain family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] subset: gosubset_prok synonym: "branched chain family amino acid anabolism" EXACT [] synonym: "branched chain family amino acid biosynthesis" EXACT [] synonym: "branched chain family amino acid formation" EXACT [] synonym: "branched chain family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0009083 name: branched chain family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] subset: gosubset_prok synonym: "branched chain family amino acid breakdown" EXACT [] synonym: "branched chain family amino acid catabolism" EXACT [] synonym: "branched chain family amino acid degradation" EXACT [] xref: Reactome:1252942 "Branched-chain amino acid catabolism" xref: Reactome:1279876 "Branched-chain amino acid catabolism" xref: Reactome:1298788 "Branched-chain amino acid catabolism" xref: Reactome:1326445 "Branched-chain amino acid catabolism" xref: Reactome:1352561 "Branched-chain amino acid catabolism" xref: Reactome:1372788 "Branched-chain amino acid catabolism" xref: Reactome:1392798 "Branched-chain amino acid catabolism" xref: Reactome:1417275 "Branched-chain amino acid catabolism" xref: Reactome:1450364 "Branched-chain amino acid catabolism" xref: Reactome:1470902 "Branched-chain amino acid catabolism" xref: Reactome:1482934 "Branched-chain amino acid catabolism" xref: Reactome:1496724 "Branched-chain amino acid catabolism" xref: Reactome:1514115 "Branched-chain amino acid catabolism" xref: Reactome:1520936 "Branched-chain amino acid catabolism" xref: Reactome:1526690 "Branched-chain amino acid catabolism" xref: Reactome:1532419 "Branched-chain amino acid catabolism" xref: Reactome:1535973 "Branched-chain amino acid catabolism" xref: Reactome:1539232 "Branched-chain amino acid catabolism" xref: Reactome:1540290 "Branched-chain amino acid catabolism" xref: Reactome:70895 "Branched-chain amino acid catabolism" is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0009084 name: glutamine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] subset: gosubset_prok synonym: "glutamine family amino acid anabolism" EXACT [] synonym: "glutamine family amino acid biosynthesis" EXACT [] synonym: "glutamine family amino acid formation" EXACT [] synonym: "glutamine family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0009085 name: lysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "lysine anabolism" EXACT [] synonym: "lysine biosynthesis" EXACT [] synonym: "lysine formation" EXACT [] synonym: "lysine synthesis" EXACT [] xref: MetaCyc:PWY-5097 is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009086 name: methionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methionine anabolism" EXACT [] synonym: "methionine biosynthesis" EXACT [] synonym: "methionine formation" EXACT [] synonym: "methionine synthesis" EXACT [] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0006555 ! methionine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009087 name: methionine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methionine breakdown" EXACT [] synonym: "methionine catabolism" EXACT [] synonym: "methionine degradation" EXACT [] xref: UM-BBD_pathwayID:met is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0006555 ! methionine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0009088 name: threonine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "threonine anabolism" EXACT [] synonym: "threonine biosynthesis" EXACT [] synonym: "threonine formation" EXACT [] synonym: "threonine synthesis" EXACT [] xref: MetaCyc:HOMOSER-THRESYN-PWY xref: MetaCyc:THRESYN-PWY is_a: GO:0006566 ! threonine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009089 name: lysine biosynthetic process via diaminopimelate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators] subset: gosubset_prok synonym: "diaminopimelate pathway" EXACT [] synonym: "diaminopimelic acid pathway" EXACT [] synonym: "lysine anabolism via diaminopimelate" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid" EXACT [] synonym: "lysine biosynthetic process via diaminopimelic acid" EXACT [] synonym: "lysine formation via diaminopimelate" EXACT [] synonym: "lysine synthesis via diaminopimelate" EXACT [] is_a: GO:0009085 ! lysine biosynthetic process is_a: GO:0046451 ! diaminopimelate metabolic process [Term] id: GO:0009090 name: homoserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "homoserine anabolism" EXACT [] synonym: "homoserine biosynthesis" EXACT [] synonym: "homoserine formation" EXACT [] synonym: "homoserine synthesis" EXACT [] xref: MetaCyc:HOMOSERSYN-PWY is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0009092 ! homoserine metabolic process [Term] id: GO:0009091 name: homoserine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "homoserine breakdown" EXACT [] synonym: "homoserine catabolism" EXACT [] synonym: "homoserine degradation" EXACT [] xref: MetaCyc:HOMOCYSDEGR-PWY is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0009092 ! homoserine metabolic process [Term] id: GO:0009092 name: homoserine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "homoserine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0009093 name: cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine breakdown" EXACT [] synonym: "cysteine catabolism" EXACT [] synonym: "cysteine degradation" EXACT [] xref: Wikipedia:Cysteine is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0009094 name: L-phenylalanine biosynthetic process namespace: biological_process alt_id: GO:0019274 alt_id: GO:0019275 def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [CHEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-phenylalanine anabolism" EXACT [] synonym: "L-phenylalanine biosynthesis" EXACT [] synonym: "L-phenylalanine formation" EXACT [] synonym: "L-phenylalanine synthesis" EXACT [] synonym: "phenylalanine biosynthesis" BROAD [] synonym: "phenylalanine biosynthetic process" BROAD [] synonym: "phenylalanine biosynthetic process, prephenate pathway" RELATED [] synonym: "phenylalanine biosynthetic process, shikimate pathway" RELATED [] is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway [Term] id: GO:0009095 name: aromatic amino acid family biosynthetic process, prephenate pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate." [GOC:mah, ISBN:0471331309 "Biochemical Pathways"] subset: gosubset_prok synonym: "aromatic amino acid family anabolism, prephenate pathway" EXACT [] synonym: "aromatic amino acid family formation, prephenate pathway" EXACT [] synonym: "aromatic amino acid family synthesis, prephenate pathway" EXACT [] is_a: GO:0009073 ! aromatic amino acid family biosynthetic process [Term] id: GO:0009097 name: isoleucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "isoleucine anabolism" EXACT [] synonym: "isoleucine biosynthesis" EXACT [] synonym: "isoleucine formation" EXACT [] synonym: "isoleucine synthesis" EXACT [] xref: MetaCyc:ILEUSYN-PWY is_a: GO:0006549 ! isoleucine metabolic process is_a: GO:0009082 ! branched chain family amino acid biosynthetic process [Term] id: GO:0009098 name: leucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "leucine anabolism" EXACT [] synonym: "leucine biosynthesis" EXACT [] synonym: "leucine formation" EXACT [] synonym: "leucine synthesis" EXACT [] xref: MetaCyc:LEUSYN-PWY is_a: GO:0006551 ! leucine metabolic process is_a: GO:0009082 ! branched chain family amino acid biosynthetic process [Term] id: GO:0009099 name: valine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "valine anabolism" EXACT [] synonym: "valine biosynthesis" EXACT [] synonym: "valine formation" EXACT [] synonym: "valine synthesis" EXACT [] xref: MetaCyc:VALSYN-PWY is_a: GO:0006573 ! valine metabolic process is_a: GO:0009082 ! branched chain family amino acid biosynthetic process [Term] id: GO:0009100 name: glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycoprotein metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0009101 name: glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycoprotein anabolism" EXACT [] synonym: "glycoprotein biosynthesis" EXACT [] synonym: "glycoprotein formation" EXACT [] synonym: "glycoprotein synthesis" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:0009102 name: biotin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "biotin anabolism" EXACT [] synonym: "biotin biosynthesis" EXACT [] synonym: "biotin formation" EXACT [] synonym: "biotin synthesis" EXACT [] synonym: "vitamin B7 biosynthesis" EXACT [] synonym: "vitamin B7 biosynthetic process" EXACT [] synonym: "vitamin H biosynthesis" EXACT [] synonym: "vitamin H biosynthetic process" EXACT [] xref: MetaCyc:BIOTIN-SYNTHESIS-PWY is_a: GO:0006768 ! biotin metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009103 name: lipopolysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai] subset: gosubset_prok synonym: "lipopolysaccharide anabolism" EXACT [] synonym: "lipopolysaccharide biosynthesis" EXACT [] synonym: "lipopolysaccharide formation" EXACT [] synonym: "lipopolysaccharide synthesis" EXACT [] synonym: "LPS biosynthetic process" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0008653 ! lipopolysaccharide metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0009104 name: lipopolysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai] subset: gosubset_prok synonym: "lipopolysaccharide breakdown" EXACT [] synonym: "lipopolysaccharide catabolism" EXACT [] synonym: "lipopolysaccharide degradation" EXACT [] synonym: "LPS catabolic process" EXACT [] is_a: GO:0008653 ! lipopolysaccharide metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0009106 name: lipoate metabolic process namespace: biological_process alt_id: GO:0000273 def: "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipoate metabolism" EXACT [] synonym: "lipoic acid metabolic process" EXACT [] synonym: "lipoic acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009107 name: lipoate biosynthetic process namespace: biological_process alt_id: GO:0009105 def: "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipoate anabolism" EXACT [] synonym: "lipoate biosynthesis" EXACT [] synonym: "lipoate formation" EXACT [] synonym: "lipoate synthesis" EXACT [] synonym: "lipoic acid anabolism" EXACT [] synonym: "lipoic acid biosynthesis" EXACT [] synonym: "lipoic acid biosynthetic process" EXACT [] synonym: "lipoic acid formation" EXACT [] synonym: "lipoic acid synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0009106 ! lipoate metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0009108 name: coenzyme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] subset: gosubset_prok synonym: "coenzyme anabolism" EXACT [] synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] synonym: "coenzyme biosynthesis" EXACT [] synonym: "coenzyme formation" EXACT [] synonym: "coenzyme synthesis" EXACT [] xref: Reactome:1253502 "Coenzyme A biosynthesis" xref: Reactome:1280441 "Coenzyme A biosynthesis" xref: Reactome:1299275 "Coenzyme A biosynthesis" xref: Reactome:1327019 "Coenzyme A biosynthesis" xref: Reactome:1353113 "Coenzyme A biosynthesis" xref: Reactome:1373302 "Coenzyme A biosynthesis" xref: Reactome:1393315 "Coenzyme A biosynthesis" xref: Reactome:1417813 "Coenzyme A biosynthesis" xref: Reactome:1450911 "Coenzyme A biosynthesis" xref: Reactome:1471291 "Coenzyme A biosynthesis" xref: Reactome:1483264 "Coenzyme A biosynthesis" xref: Reactome:1496940 "Coenzyme A biosynthesis" xref: Reactome:1514327 "Coenzyme A biosynthesis" xref: Reactome:1521192 "Coenzyme A biosynthesis" xref: Reactome:1526938 "Coenzyme A biosynthesis" xref: Reactome:1532677 "Coenzyme A biosynthesis" xref: Reactome:1536088 "Coenzyme A biosynthesis" xref: Reactome:1538059 "Coenzyme A biosynthesis" xref: Reactome:1539340 "Coenzyme A biosynthesis" xref: Reactome:1540342 "Coenzyme A biosynthesis" xref: Reactome:196783 "Coenzyme A biosynthesis" is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0009109 name: coenzyme catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] subset: gosubset_prok synonym: "coenzyme and prosthetic group catabolic process" BROAD [] synonym: "coenzyme and prosthetic group catabolism" BROAD [] synonym: "coenzyme breakdown" EXACT [] synonym: "coenzyme catabolism" EXACT [] synonym: "coenzyme degradation" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0009110 name: vitamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "vitamin anabolism" EXACT [] synonym: "vitamin biosynthesis" EXACT [] synonym: "vitamin formation" EXACT [] synonym: "vitamin synthesis" EXACT [] is_a: GO:0006766 ! vitamin metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0009111 name: vitamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: gosubset_prok synonym: "vitamin breakdown" EXACT [] synonym: "vitamin catabolism" EXACT [] synonym: "vitamin degradation" EXACT [] is_a: GO:0006766 ! vitamin metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0009112 name: nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] subset: gosubset_prok synonym: "nucleobase metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process [Term] id: GO:0009113 name: purine base biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine base anabolism" EXACT [] synonym: "purine base biosynthesis" EXACT [] synonym: "purine base formation" EXACT [] synonym: "purine base synthesis" EXACT [] synonym: "purine nucleobase biosynthetic process" EXACT [CHEBI:26386] xref: MetaCyc:PWY-841 is_a: GO:0006144 ! purine base metabolic process is_a: GO:0046112 ! nucleobase biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0009114 name: hypoxanthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] subset: gosubset_prok synonym: "hypoxanthine breakdown" EXACT [] synonym: "hypoxanthine catabolism" EXACT [] synonym: "hypoxanthine degradation" EXACT [] is_a: GO:0006145 ! purine base catabolic process is_a: GO:0046100 ! hypoxanthine metabolic process [Term] id: GO:0009115 name: xanthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "xanthine breakdown" EXACT [] synonym: "xanthine catabolism" EXACT [] synonym: "xanthine degradation" EXACT [] is_a: GO:0006145 ! purine base catabolic process is_a: GO:0046110 ! xanthine metabolic process [Term] id: GO:0009116 name: nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] subset: goslim_pir subset: gosubset_prok synonym: "nucleoside metabolism" EXACT [] is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process [Term] id: GO:0009117 name: nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] subset: goslim_pir subset: gosubset_prok synonym: "nucleotide metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009118 name: regulation of nucleoside metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of nucleoside metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009119 name: ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl] subset: gosubset_prok synonym: "ribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009120 name: deoxyribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "deoxyribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009123 name: nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside monophosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009124 name: nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside monophosphate anabolism" EXACT [] synonym: "nucleoside monophosphate biosynthesis" EXACT [] synonym: "nucleoside monophosphate formation" EXACT [] synonym: "nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0009125 name: nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside monophosphate breakdown" EXACT [] synonym: "nucleoside monophosphate catabolism" EXACT [] synonym: "nucleoside monophosphate degradation" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009166 ! nucleotide catabolic process [Term] id: GO:0009126 name: purine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009127 name: purine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside monophosphate anabolism" EXACT [] synonym: "purine nucleoside monophosphate biosynthesis" EXACT [] synonym: "purine nucleoside monophosphate formation" EXACT [] synonym: "purine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process [Term] id: GO:0009128 name: purine nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside monophosphate breakdown" EXACT [] synonym: "purine nucleoside monophosphate catabolism" EXACT [] synonym: "purine nucleoside monophosphate degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process [Term] id: GO:0009129 name: pyrimidine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009130 name: pyrimidine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside monophosphate formation" EXACT [] synonym: "pyrimidine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process [Term] id: GO:0009131 name: pyrimidine nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside monophosphate degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process [Term] id: GO:0009132 name: nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside diphosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009133 name: nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside diphosphate anabolism" EXACT [] synonym: "nucleoside diphosphate biosynthesis" EXACT [] synonym: "nucleoside diphosphate formation" EXACT [] synonym: "nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0009134 name: nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside diphosphate breakdown" EXACT [] synonym: "nucleoside diphosphate catabolism" EXACT [] synonym: "nucleoside diphosphate degradation" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0009166 ! nucleotide catabolic process [Term] id: GO:0009135 name: purine nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009136 name: purine nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside diphosphate anabolism" EXACT [] synonym: "purine nucleoside diphosphate biosynthesis" EXACT [] synonym: "purine nucleoside diphosphate formation" EXACT [] synonym: "purine nucleoside diphosphate synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process [Term] id: GO:0009137 name: purine nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside diphosphate breakdown" EXACT [] synonym: "purine nucleoside diphosphate catabolism" EXACT [] synonym: "purine nucleoside diphosphate degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process [Term] id: GO:0009138 name: pyrimidine nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009139 name: pyrimidine nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside diphosphate formation" EXACT [] synonym: "pyrimidine nucleoside diphosphate synthesis" EXACT [] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process [Term] id: GO:0009140 name: pyrimidine nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside diphosphate degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process [Term] id: GO:0009141 name: nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009142 name: nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside triphosphate anabolism" EXACT [] synonym: "nucleoside triphosphate biosynthesis" EXACT [] synonym: "nucleoside triphosphate formation" EXACT [] synonym: "nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0009143 name: nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside triphosphate breakdown" EXACT [] synonym: "nucleoside triphosphate catabolism" EXACT [] synonym: "nucleoside triphosphate degradation" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:0009166 ! nucleotide catabolic process [Term] id: GO:0009144 name: purine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009145 name: purine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside triphosphate anabolism" EXACT [] synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] synonym: "purine nucleoside triphosphate formation" EXACT [] synonym: "purine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process [Term] id: GO:0009146 name: purine nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside triphosphate breakdown" EXACT [] synonym: "purine nucleoside triphosphate catabolism" EXACT [] synonym: "purine nucleoside triphosphate degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process [Term] id: GO:0009147 name: pyrimidine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009148 name: pyrimidine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside triphosphate formation" EXACT [] synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process [Term] id: GO:0009149 name: pyrimidine nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside triphosphate degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process [Term] id: GO:0009150 name: purine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009151 name: purine deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009152 name: purine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleotide anabolism" EXACT [] synonym: "purine ribonucleotide biosynthesis" EXACT [] synonym: "purine ribonucleotide formation" EXACT [] synonym: "purine ribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009153 name: purine deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleotide anabolism" EXACT [] synonym: "purine deoxyribonucleotide biosynthesis" EXACT [] synonym: "purine deoxyribonucleotide formation" EXACT [] synonym: "purine deoxyribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process [Term] id: GO:0009154 name: purine ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleotide breakdown" EXACT [] synonym: "purine ribonucleotide catabolism" EXACT [] synonym: "purine ribonucleotide degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009155 name: purine deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleotide breakdown" EXACT [] synonym: "purine deoxyribonucleotide catabolism" EXACT [] synonym: "purine deoxyribonucleotide degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009156 name: ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside monophosphate anabolism" EXACT [] synonym: "ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "ribonucleoside monophosphate formation" EXACT [] synonym: "ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009157 name: deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside monophosphate formation" EXACT [] synonym: "deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process [Term] id: GO:0009158 name: ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside monophosphate breakdown" EXACT [] synonym: "ribonucleoside monophosphate catabolism" EXACT [] synonym: "ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009159 name: deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009161 name: ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009162 name: deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009163 name: nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "nucleoside anabolism" EXACT [] synonym: "nucleoside biosynthesis" EXACT [] synonym: "nucleoside formation" EXACT [] synonym: "nucleoside synthesis" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process [Term] id: GO:0009164 name: nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl] subset: gosubset_prok synonym: "nucleoside breakdown" EXACT [] synonym: "nucleoside catabolism" EXACT [] synonym: "nucleoside degradation" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034656 ! nucleobase, nucleoside and nucleotide catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0009165 name: nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] subset: gosubset_prok synonym: "nucleotide anabolism" EXACT [] synonym: "nucleotide biosynthesis" EXACT [] synonym: "nucleotide formation" EXACT [] synonym: "nucleotide synthesis" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process [Term] id: GO:0009166 name: nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] subset: gosubset_prok synonym: "nucleotide breakdown" EXACT [] synonym: "nucleotide catabolism" EXACT [] synonym: "nucleotide degradation" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0034656 ! nucleobase, nucleoside and nucleotide catabolic process [Term] id: GO:0009167 name: purine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009168 name: purine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside monophosphate anabolism" EXACT [] synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside monophosphate formation" EXACT [] synonym: "purine ribonucleoside monophosphate synthesis" EXACT [] xref: Reactome:1253000 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1279930 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1298825 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1326504 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1352610 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1372841 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1392855 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1417330 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1450418 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1470947 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1482987 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1496759 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1514149 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1520975 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1526726 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1532451 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1535996 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1537997 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1539250 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:1540301 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:73817 "Purine ribonucleoside monophosphate biosynthesis" is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0009169 name: purine ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside monophosphate breakdown" EXACT [] synonym: "purine ribonucleoside monophosphate catabolism" EXACT [] synonym: "purine ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0009170 name: purine deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009171 name: purine deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside monophosphate formation" EXACT [] synonym: "purine deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009172 name: purine deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009173 name: pyrimidine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0009174 name: pyrimidine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process [Term] id: GO:0009175 name: pyrimidine ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process [Term] id: GO:0009176 name: pyrimidine deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0009177 name: pyrimidine deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process [Term] id: GO:0009178 name: pyrimidine deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process [Term] id: GO:0009179 name: purine ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009180 name: purine ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside diphosphate anabolism" EXACT [] synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside diphosphate formation" EXACT [] synonym: "purine ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process [Term] id: GO:0009181 name: purine ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside diphosphate breakdown" EXACT [] synonym: "purine ribonucleoside diphosphate catabolism" EXACT [] synonym: "purine ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process [Term] id: GO:0009182 name: purine deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009183 name: purine deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside diphosphate formation" EXACT [] synonym: "purine deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process [Term] id: GO:0009184 name: purine deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process [Term] id: GO:0009185 name: ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009186 name: deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009187 name: cyclic nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyclic nucleotide metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009188 name: ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside diphosphate anabolism" EXACT [] synonym: "ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "ribonucleoside diphosphate formation" EXACT [] synonym: "ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009189 name: deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside diphosphate formation" EXACT [] synonym: "deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process [Term] id: GO:0009190 name: cyclic nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyclic nucleotide anabolism" EXACT [] synonym: "cyclic nucleotide biosynthesis" EXACT [] synonym: "cyclic nucleotide formation" EXACT [] synonym: "cyclic nucleotide synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0009191 name: ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside diphosphate breakdown" EXACT [] synonym: "ribonucleoside diphosphate catabolism" EXACT [] synonym: "ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009192 name: deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009193 name: pyrimidine ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0009194 name: pyrimidine ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process [Term] id: GO:0009195 name: pyrimidine ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process [Term] id: GO:0009196 name: pyrimidine deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0009197 name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process [Term] id: GO:0009198 name: pyrimidine deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process [Term] id: GO:0009199 name: ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009200 name: deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009201 name: ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside triphosphate anabolism" EXACT [] synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "ribonucleoside triphosphate formation" EXACT [] synonym: "ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009202 name: deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside triphosphate formation" EXACT [] synonym: "deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process [Term] id: GO:0009203 name: ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside triphosphate breakdown" EXACT [] synonym: "ribonucleoside triphosphate catabolism" EXACT [] synonym: "ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009204 name: deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009205 name: purine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009206 name: purine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside triphosphate formation" EXACT [] synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0009207 name: purine ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside triphosphate breakdown" EXACT [] synonym: "purine ribonucleoside triphosphate catabolism" EXACT [] synonym: "purine ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0009208 name: pyrimidine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0009209 name: pyrimidine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process [Term] id: GO:0009210 name: pyrimidine ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process [Term] id: GO:0009211 name: pyrimidine deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0009212 name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process [Term] id: GO:0009213 name: pyrimidine deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process [Term] id: GO:0009214 name: cyclic nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyclic nucleotide breakdown" EXACT [] synonym: "cyclic nucleotide catabolism" EXACT [] synonym: "cyclic nucleotide degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0009215 name: purine deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009216 name: purine deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside triphosphate formation" EXACT [] synonym: "purine deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009217 name: purine deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009218 name: pyrimidine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleotide metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009219 name: pyrimidine deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009220 name: pyrimidine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleotide anabolism" EXACT [] synonym: "pyrimidine ribonucleotide biosynthesis" EXACT [] synonym: "pyrimidine ribonucleotide formation" EXACT [] synonym: "pyrimidine ribonucleotide synthesis" EXACT [] xref: MetaCyc:PWY0-162 is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009221 name: pyrimidine deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleotide formation" EXACT [] synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT [] xref: MetaCyc:PWY0-166 is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process [Term] id: GO:0009222 name: pyrimidine ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleotide breakdown" EXACT [] synonym: "pyrimidine ribonucleotide catabolism" EXACT [] synonym: "pyrimidine ribonucleotide degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009223 name: pyrimidine deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleotide breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleotide catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleotide degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009224 name: CMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "CMP anabolism" EXACT [] synonym: "CMP biosynthesis" EXACT [] synonym: "CMP formation" EXACT [] synonym: "CMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0046035 ! CMP metabolic process [Term] id: GO:0009225 name: nucleotide-sugar metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "nucleotide-sugar metabolism" EXACT [] is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Term] id: GO:0009226 name: nucleotide-sugar biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleotide-sugar anabolism" EXACT [] synonym: "nucleotide-sugar biosynthesis" EXACT [] synonym: "nucleotide-sugar formation" EXACT [] synonym: "nucleotide-sugar synthesis" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009227 name: nucleotide-sugar catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleotide-sugar breakdown" EXACT [] synonym: "nucleotide-sugar catabolism" EXACT [] synonym: "nucleotide-sugar degradation" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0009228 name: thiamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "thiamin anabolism" EXACT [] synonym: "thiamin biosynthetic process" EXACT [GOC:curators] synonym: "thiamine biosynthesis" EXACT [GOC:curators] synonym: "thiamine formation" EXACT [GOC:curators] synonym: "thiamine synthesis" EXACT [GOC:curators] synonym: "vitamin B1 biosynthesis" EXACT [] synonym: "vitamin B1 biosynthetic process" EXACT [] xref: MetaCyc:THISYN-PWY is_a: GO:0006772 ! thiamine metabolic process is_a: GO:0042724 ! thiamine-containing compound biosynthetic process [Term] id: GO:0009229 name: thiamine diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [CHEBI:45931, GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "thiamin diphosphate biosynthetic process" EXACT [GOC:cuators] synonym: "thiamin pyrophosphate biosynthesis" EXACT [] synonym: "thiamin pyrophosphate biosynthetic process" EXACT [] synonym: "thiamine diphosphate anabolism" EXACT [GOC:curators] synonym: "thiamine diphosphate biosynthesis" EXACT [GOC:curators] synonym: "thiamine diphosphate formation" EXACT [GOC:curators] synonym: "thiamine diphosphate synthesis" EXACT [GOC:curators] synonym: "thiamine pyrophosphate biosynthesis" EXACT [] synonym: "thiamine pyrophosphate biosynthetic process" EXACT [] synonym: "TPP biosynthesis" EXACT [] synonym: "TPP biosynthetic process" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042357 ! thiamine diphosphate metabolic process is_a: GO:0042724 ! thiamine-containing compound biosynthetic process [Term] id: GO:0009230 name: thiamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "thiamin catabolic process" EXACT [GOC:curators] synonym: "thiamine breakdown" EXACT [GOC:curators] synonym: "thiamine catabolism" EXACT [GOC:curators] synonym: "thiamine degradation" EXACT [GOC:curators] synonym: "vitamin B1 catabolic process" EXACT [] synonym: "vitamin B1 catabolism" EXACT [] is_a: GO:0006772 ! thiamine metabolic process is_a: GO:0042725 ! thiamine-containing compound catabolic process [Term] id: GO:0009231 name: riboflavin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "riboflavin anabolism" EXACT [] synonym: "riboflavin biosynthesis" EXACT [] synonym: "riboflavin formation" EXACT [] synonym: "riboflavin synthesis" EXACT [] synonym: "vitamin B2 biosynthesis" EXACT [] synonym: "vitamin B2 biosynthetic process" EXACT [] synonym: "vitamin G biosynthesis" EXACT [] synonym: "vitamin G biosynthetic process" EXACT [] xref: MetaCyc:RIBOSYN2-PWY xref: Wikipedia:Riboflavin is_a: GO:0006771 ! riboflavin metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process [Term] id: GO:0009232 name: riboflavin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "riboflavin breakdown" EXACT [] synonym: "riboflavin catabolism" EXACT [] synonym: "riboflavin degradation" EXACT [] synonym: "vitamin B2 catabolic process" EXACT [] synonym: "vitamin B2 catabolism" EXACT [] synonym: "vitamin G catabolic process" EXACT [] synonym: "vitamin G catabolism" EXACT [] is_a: GO:0006771 ! riboflavin metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process [Term] id: GO:0009233 name: menaquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "menaquinone metabolism" EXACT [] synonym: "menatetrenone metabolic process" EXACT [] synonym: "menatetrenone metabolism" EXACT [] synonym: "multiprenylmenaquinone metabolic process" EXACT [] synonym: "multiprenylmenaquinone metabolism" EXACT [] synonym: "vitamin K2 metabolic process" EXACT [] synonym: "vitamin K2 metabolism" EXACT [] is_a: GO:0042373 ! vitamin K metabolic process [Term] id: GO:0009234 name: menaquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "menaquinone anabolism" EXACT [] synonym: "menaquinone biosynthesis" EXACT [] synonym: "menaquinone formation" EXACT [] synonym: "menaquinone synthesis" EXACT [] synonym: "menatetrenone biosynthesis" EXACT [] synonym: "menatetrenone biosynthetic process" EXACT [] synonym: "multiprenylmenaquinone biosynthesis" EXACT [] synonym: "multiprenylmenaquinone biosynthetic process" EXACT [] synonym: "vitamin K2 biosynthesis" EXACT [] synonym: "vitamin K2 biosynthetic process" EXACT [] xref: MetaCyc:MENAQUINONESYN-PWY is_a: GO:0009233 ! menaquinone metabolic process is_a: GO:0042371 ! vitamin K biosynthetic process [Term] id: GO:0009235 name: cobalamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] subset: gosubset_prok synonym: "cobalamin metabolism" EXACT [] synonym: "vitamin B12 metabolic process" EXACT [] synonym: "vitamin B12 metabolism" EXACT [] synonym: "vitamin B12 reduction" NARROW [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006778 ! porphyrin metabolic process [Term] id: GO:0009236 name: cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cobalamin anabolism" EXACT [] synonym: "cobalamin biosynthesis" EXACT [] synonym: "cobalamin formation" EXACT [] synonym: "cobalamin synthesis" EXACT [] synonym: "vitamin B12 biosynthesis" EXACT [] synonym: "vitamin B12 biosynthetic process" EXACT [] is_a: GO:0006779 ! porphyrin biosynthetic process is_a: GO:0009235 ! cobalamin metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process [Term] id: GO:0009237 name: siderophore metabolic process namespace: biological_process def: "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [ISBN:0198547684] subset: gosubset_prok synonym: "siderochrome metabolic process" NARROW [] synonym: "siderochrome metabolism" NARROW [] synonym: "siderophore metabolism" EXACT [] is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0009238 name: enterobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [ISBN:0198547684] subset: gosubset_prok synonym: "enterobactin metabolism" EXACT [] synonym: "enterochelin metabolic process" EXACT [] synonym: "enterochelin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0009239 name: enterobactin biosynthetic process namespace: biological_process alt_id: GO:0031191 alt_id: GO:0031192 def: "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:go_curators] subset: gosubset_prok synonym: "enterobactin anabolism" EXACT [] synonym: "enterobactin biosynthesis" EXACT [] synonym: "enterobactin biosynthetic process, peptide formation" NARROW [] synonym: "enterobactin biosynthetic process, peptide modification" NARROW [] synonym: "enterobactin formation" EXACT [] synonym: "enterobactin synthesis" EXACT [] synonym: "enterobactin synthetase" RELATED [] synonym: "enterochelin biosynthesis" EXACT [] synonym: "enterochelin biosynthetic process" EXACT [] xref: MetaCyc:ENTBACSYN-PWY is_a: GO:0009238 ! enterobactin metabolic process is_a: GO:0019540 ! siderophore biosynthetic process from catechol [Term] id: GO:0009240 name: isopentenyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "IPP biosynthesis" EXACT [] synonym: "IPP biosynthetic process" EXACT [] synonym: "isopentenyl diphosphate anabolism" EXACT [] synonym: "isopentenyl diphosphate biosynthesis" EXACT [] synonym: "isopentenyl diphosphate formation" EXACT [] synonym: "isopentenyl diphosphate synthesis" EXACT [] synonym: "isopentenyl pyrophosphate biosynthesis" EXACT [] synonym: "isopentenyl pyrophosphate biosynthetic process" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046490 ! isopentenyl diphosphate metabolic process relationship: part_of GO:0008299 ! isoprenoid biosynthetic process [Term] id: GO:0009242 name: colanic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide." [GOC:ai] subset: gosubset_prok synonym: "colanic acid anabolism" EXACT [] synonym: "colanic acid biosynthesis" EXACT [] synonym: "colanic acid formation" EXACT [] synonym: "colanic acid synthesis" EXACT [] synonym: "M antigen biosynthesis" EXACT [] synonym: "M antigen biosynthetic process" EXACT [] xref: MetaCyc:COLANSYN-PWY is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046377 ! colanic acid metabolic process [Term] id: GO:0009243 name: O antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "O antigen anabolism" EXACT [] synonym: "O antigen biosynthesis" EXACT [] synonym: "O antigen formation" EXACT [] synonym: "O antigen synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046402 ! O antigen metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009244 name: lipopolysaccharide core region biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipopolysaccharide core region anabolism" EXACT [] synonym: "lipopolysaccharide core region biosynthesis" EXACT [] synonym: "lipopolysaccharide core region formation" EXACT [] synonym: "lipopolysaccharide core region synthesis" EXACT [] synonym: "LPS core region biosynthetic process" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process is_a: GO:0046401 ! lipopolysaccharide core region metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009245 name: lipid A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipid A anabolism" EXACT [] synonym: "lipid A biosynthesis" EXACT [] synonym: "lipid A formation" EXACT [] synonym: "lipid A synthesis" EXACT [] xref: MetaCyc:NAGLIPASYN-PWY is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0046493 ! lipid A metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009246 name: enterobacterial common antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] subset: gosubset_prok synonym: "enterobacterial common antigen anabolism" EXACT [] synonym: "enterobacterial common antigen biosynthesis" EXACT [] synonym: "enterobacterial common antigen formation" EXACT [] synonym: "enterobacterial common antigen synthesis" EXACT [] xref: MetaCyc:ECASYN-PWY is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046378 ! enterobacterial common antigen metabolic process [Term] id: GO:0009247 name: glycolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators] subset: gosubset_prok synonym: "glycolipid anabolism" EXACT [] synonym: "glycolipid biosynthesis" EXACT [] synonym: "glycolipid formation" EXACT [] synonym: "glycolipid synthesis" EXACT [] xref: MetaCyc:PWY-401 is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046467 ! membrane lipid biosynthetic process [Term] id: GO:0009248 name: K antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "K antigen anabolism" EXACT [] synonym: "K antigen biosynthesis" EXACT [] synonym: "K antigen formation" EXACT [] synonym: "K antigen synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046375 ! K antigen metabolic process [Term] id: GO:0009249 name: protein lipoylation namespace: biological_process def: "The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0009250 name: glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] subset: gosubset_prok synonym: "glucan anabolism" EXACT [] synonym: "glucan biosynthesis" EXACT [] synonym: "glucan formation" EXACT [] synonym: "glucan synthesis" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0009251 name: glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] subset: gosubset_prok synonym: "glucan breakdown" EXACT [] synonym: "glucan catabolism" EXACT [] synonym: "glucan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044042 ! glucan metabolic process [Term] id: GO:0009252 name: peptidoglycan biosynthetic process namespace: biological_process alt_id: GO:0009285 def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "murein biosynthesis" EXACT [] synonym: "murein biosynthetic process" EXACT [] synonym: "peptidoglycan anabolism" EXACT [] synonym: "peptidoglycan biosynthesis" EXACT [] synonym: "peptidoglycan formation" EXACT [] synonym: "peptidoglycan synthesis" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0009253 name: peptidoglycan catabolic process namespace: biological_process alt_id: GO:0009286 def: "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "murein catabolic process" EXACT [] synonym: "murein catabolism" EXACT [] synonym: "peptidoglycan breakdown" EXACT [] synonym: "peptidoglycan catabolism" EXACT [] synonym: "peptidoglycan degradation" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process is_a: GO:0006027 ! glycosaminoglycan catabolic process [Term] id: GO:0009254 name: peptidoglycan turnover namespace: biological_process alt_id: GO:0009287 def: "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall." [GOC:jl] subset: gosubset_prok synonym: "murein turnover" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process [Term] id: GO:0009255 name: Entner-Doudoroff pathway namespace: biological_process def: "A pathway that converts glucose to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it." [GOC:jl, MetaCyc:ENTNER-DOUDOROFF-PWY] subset: gosubset_prok xref: MetaCyc:ENTNER-DOUDOROFF-PWY is_a: GO:0044262 ! cellular carbohydrate metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0009256 name: 10-formyltetrahydrofolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] subset: gosubset_prok synonym: "10-formyl-THF metabolic process" EXACT [] synonym: "10-formyl-THF metabolism" EXACT [] synonym: "10-formyltetrahydrofolate metabolism" EXACT [] is_a: GO:0046653 ! tetrahydrofolate metabolic process [Term] id: GO:0009257 name: 10-formyltetrahydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] subset: gosubset_prok synonym: "10-formyl-THF biosynthesis" EXACT [] synonym: "10-formyl-THF biosynthetic process" EXACT [] synonym: "10-formyltetrahydrofolate anabolism" EXACT [] synonym: "10-formyltetrahydrofolate biosynthesis" EXACT [] synonym: "10-formyltetrahydrofolate formation" EXACT [] synonym: "10-formyltetrahydrofolate synthesis" EXACT [] xref: MetaCyc:1CMET2-PWY xref: MetaCyc:PWY-3841 is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process is_a: GO:0046654 ! tetrahydrofolate biosynthetic process [Term] id: GO:0009258 name: 10-formyltetrahydrofolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] subset: gosubset_prok synonym: "10-formyl-THF catabolic process" EXACT [] synonym: "10-formyl-THF catabolism" EXACT [] synonym: "10-formyltetrahydrofolate breakdown" EXACT [] synonym: "10-formyltetrahydrofolate catabolism" EXACT [] synonym: "10-formyltetrahydrofolate degradation" EXACT [] is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process is_a: GO:0009397 ! folic acid-containing compound catabolic process [Term] id: GO:0009259 name: ribonucleotide metabolic process namespace: biological_process alt_id: GO:0009121 def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009260 name: ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleotide anabolism" EXACT [] synonym: "ribonucleotide biosynthesis" EXACT [] synonym: "ribonucleotide formation" EXACT [] synonym: "ribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009261 name: ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleotide breakdown" EXACT [] synonym: "ribonucleotide catabolism" EXACT [] synonym: "ribonucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009262 name: deoxyribonucleotide metabolic process namespace: biological_process alt_id: GO:0009122 alt_id: GO:0009393 def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009263 name: deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleotide anabolism" EXACT [] synonym: "deoxyribonucleotide biosynthesis" EXACT [] synonym: "deoxyribonucleotide formation" EXACT [] synonym: "deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009264 name: deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleotide breakdown" EXACT [] synonym: "deoxyribonucleotide catabolism" EXACT [] synonym: "deoxyribonucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009265 name: 2'-deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] subset: gosubset_prok synonym: "2'-deoxyribonucleotide anabolism" EXACT [] synonym: "2'-deoxyribonucleotide biosynthesis" EXACT [] synonym: "2'-deoxyribonucleotide formation" EXACT [] synonym: "2'-deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009266 name: response to temperature stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] subset: gosubset_prok synonym: "response to thermal stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009267 name: cellular response to starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] subset: gosubset_prok is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0033554 ! cellular response to stress is_a: GO:0042594 ! response to starvation [Term] id: GO:0009268 name: response to pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus." [GOC:jl] subset: gosubset_prok is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009269 name: response to desiccation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl] subset: gosubset_prok synonym: "desiccation tolerance" RELATED [] is_a: GO:0009414 ! response to water deprivation [Term] id: GO:0009270 name: response to humidity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl] is_a: GO:0009415 ! response to water [Term] id: GO:0009271 name: phage shock namespace: biological_process def: "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage." [GOC:add, GOC:jl, PMID:15485810, PMID:16045608] subset: gosubset_prok is_a: GO:0006950 ! response to stress is_a: GO:0009615 ! response to virus [Term] id: GO:0009272 name: fungal-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu] synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW [GOC:mah] synonym: "fungal-type cell wall anabolism" RELATED [GOC:mah] synonym: "fungal-type cell wall biosynthetic process" RELATED [GOC:mah] synonym: "fungal-type cell wall formation" RELATED [GOC:mah] synonym: "fungal-type cell wall synthesis" RELATED [GOC:mah] is_a: GO:0042546 ! cell wall biogenesis is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis [Term] id: GO:0009273 name: peptidoglycan-based cell wall biogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli." [GOC:go_curators] subset: gosubset_prok synonym: "cell envelope biosynthesis" BROAD [] synonym: "cell envelope biosynthetic process" BROAD [] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] is_a: GO:0042546 ! cell wall biogenesis [Term] id: GO:0009274 name: peptidoglycan-based cell wall namespace: cellular_component def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli." [GOC:mlg, ISBN:0815108893] subset: gosubset_prok synonym: "envelope" BROAD [] synonym: "murein sacculus" RELATED [] synonym: "peptidoglycan" NARROW [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009275 name: Gram-positive-bacterium-type cell wall namespace: cellular_component def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria." [GOC:mlg, ISBN:0051406910, ISBN:0815108893] subset: gosubset_prok synonym: "20-80nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall of Gram-positive Bacteria" EXACT [] is_a: GO:0009274 ! peptidoglycan-based cell wall [Term] id: GO:0009276 name: Gram-negative-bacterium-type cell wall namespace: cellular_component def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain." [GOC:mlg, ISBN:0815108893] subset: gosubset_prok synonym: "1-2nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall inner membrane" EXACT [] is_a: GO:0009274 ! peptidoglycan-based cell wall relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0009277 name: fungal-type cell wall namespace: cellular_component def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422] synonym: "beta-glucan-containing cell wall" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall" NARROW [] synonym: "chitin-containing cell wall" RELATED [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009278 name: murein sacculus namespace: cellular_component def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma] comment: This term was made obsolete because it was defined inaccurately. is_obsolete: true consider: GO:0009276 [Term] id: GO:0009279 name: cell outer membrane namespace: cellular_component def: "A lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:mtg_sensu, ISBN:0135712254] subset: gosubset_prok synonym: "outer membrane of cell" EXACT [] is_a: GO:0019867 ! outer membrane is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0009280 name: cell wall inner membrane namespace: cellular_component def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma] comment: This term was made obsolete because it was defined inaccurately. synonym: "cytoplasmic membrane" BROAD [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0009288 name: bacterial-type flagellum namespace: cellular_component def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:jh2, GOC:mtg_sensu, PMID:7787060] subset: gosubset_prok synonym: "flagellin-based flagellum" EXACT [] is_a: GO:0019861 ! flagellum is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0009289 name: pilus namespace: cellular_component def: "A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators] subset: goslim_pir subset: gosubset_prok synonym: "fimbria" EXACT [] synonym: "fimbriae" EXACT [] synonym: "fimbrium" EXACT [] synonym: "pili" EXACT [] xref: Wikipedia:Pilus is_a: GO:0042995 ! cell projection [Term] id: GO:0009290 name: DNA import into cell involved in transformation namespace: biological_process def: "The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell." [GOC:ai] subset: gosubset_prok synonym: "cellular DNA import during transformation" RELATED [] synonym: "cellular DNA uptake" BROAD [] synonym: "DNA import into cell" BROAD [] synonym: "DNA import into cell involved in transformation" RELATED [GOC:dph, GOC:tb] synonym: "DNA transport into cell during transformation" RELATED [] is_a: GO:0051027 ! DNA transport relationship: part_of GO:0009294 ! DNA mediated transformation [Term] id: GO:0009291 name: unidirectional conjugation namespace: biological_process def: "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in Prokaryotes." [ISBN:0387520546] subset: gosubset_prok synonym: "mating" BROAD [] is_a: GO:0000746 ! conjugation is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009292 name: genetic transfer namespace: biological_process def: "In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual." [GOC:clt] subset: goslim_pir subset: gosubset_prok synonym: "genetic exchange" BROAD [] is_a: GO:0051704 ! multi-organism process [Term] id: GO:0009293 name: transduction namespace: biological_process def: "The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Wikipedia:Transduction_(genetics) is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009294 name: DNA mediated transformation namespace: biological_process def: "The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material." [ISBN:0716720094, Wikipedia:Transformation_(genetics)] subset: gosubset_prok synonym: "DNA-mediated transformation" EXACT [] is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009295 name: nucleoid namespace: cellular_component def: "The region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined." [GOC:ma, ISBN:3540076689] subset: gosubset_prok xref: Wikipedia:Nucleoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0009296 name: flagellum assembly namespace: biological_process def: "The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers." [GOC:curators, ISBN:0815316194] subset: gosubset_prok synonym: "flagella assembly" EXACT [GOC:mah] synonym: "flagella biogenesis" RELATED [] synonym: "flagellum biogenesis" RELATED [GOC:mah] is_a: GO:0030031 ! cell projection assembly is_a: GO:0043064 ! flagellum organization [Term] id: GO:0009297 name: pilus assembly namespace: biological_process def: "The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles." [GOC:dgh, GOC:mcc2, GOC:tb] subset: gosubset_prok synonym: "fimbria assembly" NARROW [] synonym: "fimbria biogenesis" RELATED [] synonym: "fimbriae assembly" NARROW [] synonym: "fimbriae biogenesis" RELATED [] synonym: "fimbrial assembly" NARROW [] synonym: "fimbrial biogenesis" NARROW [] synonym: "fimbrium assembly" NARROW [] synonym: "fimbrium biogenesis" RELATED [] synonym: "pili biosynthesis" EXACT [] synonym: "pili biosynthetic process" EXACT [] synonym: "pilus biogenesis" RELATED [] synonym: "pilus biosynthesis" EXACT [] synonym: "pilus formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0030031 ! cell projection assembly is_a: GO:0043711 ! pilus organization [Term] id: GO:0009298 name: GDP-mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "GDP-mannose anabolism" EXACT [] synonym: "GDP-mannose biosynthesis" EXACT [] synonym: "GDP-mannose formation" EXACT [] synonym: "GDP-mannose synthesis" EXACT [] xref: Reactome:446205 "Synthesis of GDP-mannose" is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0019307 ! mannose biosynthetic process is_a: GO:0019673 ! GDP-mannose metabolic process [Term] id: GO:0009299 name: mRNA transcription namespace: biological_process alt_id: GO:0061023 def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template." [GOC:jl] subset: gosubset_prok synonym: "cellular mRNA transcription" EXACT [] synonym: "mRNA biosynthesis" BROAD [] synonym: "mRNA biosynthetic process" BROAD [] synonym: "mRNA synthesis" BROAD [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0009300 name: antisense RNA transcription namespace: biological_process def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl] subset: gosubset_prok is_a: GO:0006351 ! transcription, DNA-dependent is_a: GO:0042868 ! antisense RNA metabolic process [Term] id: GO:0009301 name: snRNA transcription namespace: biological_process def: "The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0009302 name: snoRNA transcription namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template." [GOC:jl] is_a: GO:0006351 ! transcription, DNA-dependent is_a: GO:0016074 ! snoRNA metabolic process [Term] id: GO:0009303 name: rRNA transcription namespace: biological_process def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "rRNA biosynthesis" BROAD [] synonym: "rRNA biosynthetic process" BROAD [] synonym: "rRNA synthesis" BROAD [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0009304 name: tRNA transcription namespace: biological_process def: "The synthesis of transfer RNA (tRNA) from a DNA template." [GOC:jl] subset: gosubset_prok synonym: "tRNA biosynthesis" BROAD [] synonym: "tRNA biosynthetic process" BROAD [] synonym: "tRNA synthesis" BROAD [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0009305 name: protein biotinylation namespace: biological_process def: "The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid biotinylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0009306 name: protein secretion namespace: biological_process alt_id: GO:0045166 alt_id: GO:0045731 def: "The controlled release of proteins from a cell or group of cells." [GOC:ai] subset: gosubset_prok synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0009307 name: DNA restriction-modification system namespace: biological_process def: "Any process that protect an organism from invading foreign DNA by methylation of self DNA at specific sequences and nucleolytic cleavage of unmethylated foreign DNA." [GOC:mah] subset: gosubset_prok synonym: "DNA restriction" BROAD [] is_a: GO:0006304 ! DNA modification [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "amine metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0009309 name: amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amine anabolism" EXACT [] synonym: "amine biosynthesis" EXACT [] synonym: "amine formation" EXACT [] synonym: "amine synthesis" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0009310 name: amine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amine breakdown" EXACT [] synonym: "amine catabolism" EXACT [] synonym: "amine degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0009311 name: oligosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oligosaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0009312 name: oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oligosaccharide anabolism" EXACT [] synonym: "oligosaccharide biosynthesis" EXACT [] synonym: "oligosaccharide formation" EXACT [] synonym: "oligosaccharide synthesis" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0009313 name: oligosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oligosaccharide breakdown" EXACT [] synonym: "oligosaccharide catabolism" EXACT [] synonym: "oligosaccharide degradation" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. subset: gosubset_prok synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009315 name: drug resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0042493 [Term] id: GO:0009316 name: 3-isopropylmalate dehydratase complex namespace: cellular_component def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, MetaCyc:3-ISOPROPYLMALISOM-CPLX, PMID:7026530] comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'. subset: gosubset_prok synonym: "isopropylmalate isomerase complex" EXACT [] xref: MetaCyc:3-ISOPROPYLMALISOM-CPLX is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0009317 name: acetyl-CoA carboxylase complex namespace: cellular_component def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720] subset: goslim_pir subset: gosubset_prok synonym: "ACCase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009318 name: exodeoxyribonuclease VII complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009319 name: cytochrome o ubiquinol oxidase complex namespace: cellular_component def: "A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups." [GOC:mah, MetaCyc:CYT-O-UBIOX-CPLX, PMID:11017202, PMID:3052268] comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'. subset: gosubset_prok xref: MetaCyc:CYT-O-UBIOX-CPLX is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0016021 ! integral to membrane [Term] id: GO:0009320 name: phosphoribosylaminoimidazole carboxylase complex namespace: cellular_component def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah] comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009321 name: alkyl hydroperoxide reductase complex namespace: cellular_component def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [BRENDA:1.11.1.15, GOC:jl, PMID:2649484] comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009322 name: trimethylamine-N-oxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [EC:1.6.6.9] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009323 name: ribosomal-protein-alanine N-acetyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128] is_a: GO:0031248 ! protein acetyltransferase complex [Term] id: GO:0009324 name: D-amino-acid dehydrogenase complex namespace: cellular_component def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah] comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0009325 name: nitrate reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009326 name: formate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [EC:1.2.1.2] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009327 name: NAD(P)+ transhydrogenase complex (AB-specific) namespace: cellular_component def: "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [BRENDA:1.6.1.2, GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009328 name: phenylalanine-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009329 name: acetate CoA-transferase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, PMID:2719476, PMID:8423010] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex [Term] id: GO:0009330 name: DNA topoisomerase complex (ATP-hydrolyzing) namespace: cellular_component def: "Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] comment: See also the molecular function term 'DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009331 name: glycerol-3-phosphate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009332 name: glutamate-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009333 name: cysteine synthase complex namespace: cellular_component def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009334 name: 3-phenylpropionate dioxygenase complex namespace: cellular_component def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, MetaCyc:HCAMULTI-CPLX, PMID:9603882] comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'. xref: MetaCyc:HCAMULTI-CPLX is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009335 name: holo-[acyl-carrier protein] synthase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7] comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term. synonym: "holo-ACP synthase complex" EXACT [] is_obsolete: true consider: GO:0005835 [Term] id: GO:0009336 name: sulfate adenylyltransferase complex (ATP) namespace: cellular_component def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4] synonym: "sulphate adenylyltransferase complex (ATP)" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009337 name: sulfite reductase complex (NADPH) namespace: cellular_component def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide." [BRENDA:1.8.1.2, GOC:jl] comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'. subset: gosubset_prok synonym: "sulphite reductase complex (NADPH)" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009338 name: exodeoxyribonuclease V complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009339 name: glycolate oxidase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009340 name: DNA topoisomerase IV complex namespace: cellular_component def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, PMID:7783632] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009341 name: beta-galactosidase complex namespace: cellular_component def: "A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species." [BRENDA:3.2.1.2, EC:3.2.1.23, PMID:15950161] subset: gosubset_prok is_a: GO:0043234 ! protein complex [Term] id: GO:0009342 name: glutamate synthase complex (NADPH) namespace: cellular_component def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah] subset: gosubset_prok is_a: GO:0031026 ! glutamate synthase complex [Term] id: GO:0009343 name: biotin carboxylase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex [Term] id: GO:0009344 name: nitrite reductase complex [NAD(P)H] namespace: cellular_component def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah] comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'. is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009345 name: glycine-tRNA ligase complex namespace: cellular_component def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, PMID:15733854] subset: gosubset_prok synonym: "glycine-tRNA synthetase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009346 name: citrate lyase complex namespace: cellular_component def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009347 name: aspartate carbamoyltransferase complex namespace: cellular_component def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693] comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009348 name: ornithine carbamoyltransferase complex namespace: cellular_component def: "A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline." [EC:2.1.3.3, GOC:mah] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009349 name: riboflavin synthase complex namespace: cellular_component def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009350 name: ethanolamine ammonia-lyase complex namespace: cellular_component def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009351 name: dihydrolipoamide S-acyltransferase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12] comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide. is_obsolete: true [Term] id: GO:0009352 name: dihydrolipoyl dehydrogenase complex namespace: cellular_component def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah] comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself. synonym: "dihydrolipoamide dehydrogenase complex" EXACT [] is_obsolete: true consider: GO:0004148 consider: GO:0045240 consider: GO:0045254 [Term] id: GO:0009353 name: mitochondrial oxoglutarate dehydrogenase complex namespace: cellular_component def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus." [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. is_a: GO:0044429 ! mitochondrial part is_a: GO:0045252 ! oxoglutarate dehydrogenase complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0009354 name: dihydrolipoamide S-succinyltransferase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61] comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide. is_obsolete: true consider: GO:0045252 [Term] id: GO:0009355 name: DNA polymerase V complex namespace: cellular_component def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196] is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0009356 name: aminodeoxychorismate synthase complex namespace: cellular_component def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344] synonym: "4-amino-4-deoxychorismate synthase complex" RELATED [] synonym: "ADC synthase complex" EXACT [] synonym: "p-aminobenzoate synthetase complex" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009357 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009358 name: polyphosphate kinase complex namespace: cellular_component def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah] comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009359 name: Type II site-specific deoxyribonuclease complex namespace: cellular_component def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] subset: gosubset_prok synonym: "Type II restriction enzyme complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009360 name: DNA polymerase III complex namespace: cellular_component def: "A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:11525729, PMID:12940977] subset: gosubset_prok is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0009361 name: succinate-CoA ligase complex (ADP-forming) namespace: cellular_component def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [EC:6.2.1.5, GOC:jl] subset: gosubset_prok synonym: "succinyl-CoA synthetase, ADP-forming" EXACT [CORUM:394] is_a: GO:0042709 ! succinate-CoA ligase complex [Term] id: GO:0009365 name: protein histidine kinase complex namespace: cellular_component def: "A complex that possesses protein histidine kinase activity." [GOC:mah] is_a: GO:0043234 ! protein complex [Term] id: GO:0009366 name: enterobactin synthetase complex namespace: cellular_component def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [MetaCyc:ENTMULTI-CPLX, PMID:9485415] subset: gosubset_prok synonym: "enterochelin synthetase complex" EXACT [] xref: MetaCyc:ENTMULTI-CPLX is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009367 name: prepilin peptidase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43] comment: This term was made obsolete because prepilin peptidase is a single gene product, and there is no evidence that it acts as a multimer. is_obsolete: true [Term] id: GO:0009368 name: endopeptidase Clp complex namespace: cellular_component def: "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009371 name: positive regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators] subset: gosubset_prok synonym: "activation of transcription by pheromones" NARROW [] synonym: "stimulation of transcription by pheromones" NARROW [] synonym: "up regulation of transcription by pheromones" EXACT [] synonym: "up-regulation of transcription by pheromones" EXACT [] synonym: "upregulation of transcription by pheromones" EXACT [] is_a: GO:0009373 ! regulation of transcription by pheromones is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent [Term] id: GO:0009372 name: quorum sensing namespace: biological_process def: "The process in which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves." [PMID:15716452, PMID:8288518] subset: goslim_pir subset: gosubset_prok synonym: "quorum sensing system" EXACT [] xref: Wikipedia:Quorum_sensing is_a: GO:0048874 ! homeostasis of number of cells in a free-living population [Term] id: GO:0009373 name: regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0071444 ! cellular response to pheromone [Term] id: GO:0009374 name: biotin binding namespace: molecular_function def: "Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "vitamin B7 binding" EXACT [] synonym: "vitamin H binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0009375 name: ferredoxin hydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.12.7.2] subset: gosubset_prok synonym: "hydrogenase complex" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009376 name: HslUV protease complex namespace: cellular_component def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other Clp family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, six identical subunits of both the ATPase, ClpY, and the protease, ClpQ, self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, form a dumbbell-shaped complex." [PMID:12670962] subset: gosubset_prok synonym: "ClpYQ protease complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009377 name: HslUV protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok is_obsolete: true replaced_by: GO:0070011 [Term] id: GO:0009378 name: four-way junction helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895] subset: gosubset_prok synonym: "Holliday junction helicase activity" NARROW [] is_a: GO:0003678 ! DNA helicase activity [Term] id: GO:0009379 name: Holliday junction helicase complex namespace: cellular_component def: "A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA." [PMID:16935884, PMID:9442895] subset: gosubset_prok is_a: GO:0033202 ! DNA helicase complex relationship: part_of GO:0048476 ! Holliday junction resolvase complex [Term] id: GO:0009380 name: excinuclease repair complex namespace: cellular_component def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and one B subunit bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between subunit B and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:15192705] subset: gosubset_prok synonym: "excinuclease ABC complex" EXACT [] synonym: "UvrABC excinuclease complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009381 name: excinuclease ABC activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705] subset: gosubset_prok is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0009382 name: imidazoleglycerol-phosphate synthase complex namespace: cellular_component def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah] comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'. subset: gosubset_prok synonym: "imidazoleglycerol phosphate synthase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009383 name: rRNA (cytosine-C5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA." [GOC:imk, PMID:10026269, PMID:18786544] synonym: "rRNA (cytosine-C5-967)-methyltransferase activity" NARROW [] synonym: "rRNA m5C967 methyltransferase activity" NARROW [] xref: EC:2.1.1.- is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity [Term] id: GO:0009384 name: N-acylmannosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60] subset: gosubset_prok synonym: "acetylamidodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "acylaminodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase (phosphorylating)" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "N-acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "N-acyl-D-mannosamine kinase activity" EXACT [EC:2.7.1.60] xref: EC:2.7.1.60 xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0009385 name: N-acylmannosamine-6-phosphate 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [MetaCyc:NANE-RXN] synonym: "N-acylmannosamine-6-P epimerase activity" EXACT [] xref: EC:5.-.-.- xref: MetaCyc:NANE-RXN is_a: GO:0016853 ! isomerase activity [Term] id: GO:0009386 name: translational attenuation namespace: biological_process def: "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation." [PMID:15694341, PMID:15805513] subset: gosubset_prok is_a: GO:0006417 ! regulation of translation [Term] id: GO:0009388 name: antisense RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0009389 name: dimethyl sulfoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [UM-BBD_reactionID:r0207] subset: gosubset_prok synonym: "dimethyl sulphoxide reductase activity" EXACT [] xref: EC:1.8.99.- xref: UM-BBD_reactionID:r0207 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0009390 name: dimethyl sulfoxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188] synonym: "dimethyl sulphoxide reductase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009392 name: N-acetyl-anhydromuramoyl-L-alanine amidase activity namespace: molecular_function def: "Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala." [MetaCyc:RXN0-5225] xref: MetaCyc:RXN0-5225 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0009394 name: 2'-deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] subset: gosubset_prok synonym: "2'-deoxyribonucleotide metabolism" EXACT [] is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009395 name: phospholipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phospholipid breakdown" EXACT [] synonym: "phospholipid catabolism" EXACT [] synonym: "phospholipid degradation" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0009396 name: folic acid-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai] subset: gosubset_prok synonym: "folate and derivative biosynthesis" EXACT [] synonym: "folate and derivative biosynthetic process" EXACT [] synonym: "folate-containing compound biosynthesis" EXACT [GOC:curators] synonym: "folate-containing compound biosynthetic process" EXACT [GOC:curators] synonym: "folic acid and derivative biosynthesis" EXACT [] synonym: "folic acid and derivative biosynthetic process" EXACT [GOC:curators] synonym: "folic acid-containing compound anabolism" EXACT [GOC:curators] synonym: "folic acid-containing compound biosynthesis" EXACT [GOC:curators] synonym: "folic acid-containing compound formation" EXACT [GOC:curators] synonym: "folic acid-containing compound synthesis" EXACT [GOC:curators] synonym: "vitamin B9 and derivative biosynthesis" EXACT [] synonym: "vitamin B9 and derivative biosynthetic process" EXACT [] synonym: "vitamin M and derivative biosynthesis" EXACT [] synonym: "vitamin M and derivative biosynthetic process" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process [Term] id: GO:0009397 name: folic acid-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives." [GOC:ai] subset: gosubset_prok synonym: "folate and derivative catabolic process" EXACT [] synonym: "folate and derivative catabolism" EXACT [] synonym: "folate-containing compound catabolic process" EXACT [GOC:curators] synonym: "folate-containing compound catabolism" EXACT [GOC:curators] synonym: "folic acid and derivative catabolic process" EXACT [GOC:curators] synonym: "folic acid and derivative catabolism" EXACT [] synonym: "folic acid-containing compound breakdown" EXACT [GOC:curators] synonym: "folic acid-containing compound catabolism" EXACT [GOC:curators] synonym: "folic acid-containing compound degradation" EXACT [GOC:curators] synonym: "vitamin B9 and derivative catabolic process" EXACT [] synonym: "vitamin B9 and derivative catabolism" EXACT [] synonym: "vitamin M and derivative catabolic process" EXACT [] synonym: "vitamin M and derivative catabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process [Term] id: GO:0009398 name: FMN biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [CHEBI:17621, GOC:ai] subset: gosubset_prok synonym: "FMN anabolism" EXACT [] synonym: "FMN biosynthesis" EXACT [] synonym: "FMN formation" EXACT [] synonym: "FMN synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process is_a: GO:0046444 ! FMN metabolic process [Term] id: GO:0009399 name: nitrogen fixation namespace: biological_process def: "The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide." [Wikipedia:Nitrogen_fixation] subset: gosubset_prok xref: MetaCyc:N2FIX-PWY xref: Wikipedia:Nitrogen_fixation is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0009400 name: receptor signaling protein serine/threonine phosphatase activity namespace: molecular_function def: "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf, GOC:mah] synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT [] is_a: GO:0004722 ! protein serine/threonine phosphatase activity is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0009401 name: phosphoenolpyruvate-dependent sugar phosphotransferase system namespace: biological_process def: "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html] subset: gosubset_prok synonym: "PTS system" NARROW [] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0009402 name: toxin resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0009636 [Term] id: GO:0009403 name: toxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] subset: gosubset_prok synonym: "toxin anabolism" EXACT [] synonym: "toxin biosynthesis" EXACT [] synonym: "toxin formation" EXACT [] synonym: "toxin synthesis" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009404 name: toxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2] subset: goslim_pir subset: gosubset_prok synonym: "toxin metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0009405 name: pathogenesis namespace: biological_process def: "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself. subset: goslim_candida subset: gosubset_prok synonym: "channel-forming toxin activity" RELATED [] synonym: "cytotoxin activity" RELATED [] synonym: "endotoxin activity" RELATED [] synonym: "enterotoxin activity" RELATED [] synonym: "exotoxin activity" RELATED [] synonym: "lipoprotein toxin" RELATED [] synonym: "neurotoxin activity" RELATED [] synonym: "pore-forming toxin activity" RELATED [] synonym: "toxin activity" RELATED [] synonym: "virulence" RELATED [] is_a: GO:0051704 ! multi-organism process [Term] id: GO:0009406 name: virulence namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a phenotype rather than a biological process. is_obsolete: true consider: GO:0009405 consider: GO:0016032 [Term] id: GO:0009407 name: toxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] subset: gosubset_prok synonym: "toxin breakdown" EXACT [] synonym: "toxin catabolism" EXACT [] synonym: "toxin degradation" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0009408 name: response to heat namespace: biological_process alt_id: GO:0006951 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] subset: gosubset_prok synonym: "response to heat shock" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009409 name: response to cold namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr] subset: gosubset_prok synonym: "freezing tolerance" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009410 name: response to xenobiotic stimulus namespace: biological_process alt_id: GO:0017104 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:jl] subset: gosubset_prok is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0009411 name: response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] subset: gosubset_prok synonym: "response to ultraviolet light stimulus" EXACT [] synonym: "response to ultraviolet radiation stimulus" EXACT [] synonym: "response to UV light stimulus" EXACT [] synonym: "response to UV radiation stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009412 name: response to heavy metal namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0010038 [Term] id: GO:0009413 name: response to flooding namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water." [GOC:lr] comment: Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle. is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009414 name: response to water deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr] subset: gosubset_prok synonym: "drought tolerance" RELATED [] synonym: "response to dehydration" EXACT [] synonym: "response to drought" EXACT [] synonym: "response to thirst" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009415 name: response to water namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus." [GOC:jl] subset: gosubset_prok is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] subset: gosubset_prok is_a: GO:0009314 ! response to radiation [Term] id: GO:0009417 name: fimbrin namespace: cellular_component def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0009289 [Term] id: GO:0009418 name: pilus shaft namespace: cellular_component def: "The long, slender, mid section of a pilus." [GOC:jl] subset: gosubset_prok synonym: "fimbrial shaft" EXACT [] is_a: GO:0044443 ! pilus part [Term] id: GO:0009419 name: pilus tip namespace: cellular_component def: "The pointed extremity furthest from the cell of a pilus." [GOC:jl] subset: gosubset_prok synonym: "fimbrial tip" EXACT [] is_a: GO:0044443 ! pilus part [Term] id: GO:0009420 name: bacterial-type flagellum filament namespace: cellular_component def: "The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar filament" EXACT [] synonym: "flagellin-based flagellum filament" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009421 name: bacterial-type flagellum filament cap namespace: cellular_component def: "The proteinaceous structure at the distal tip of the flagellar filament. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar filament cap" EXACT [] synonym: "flagellin-based flagellum filament cap" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009420 ! bacterial-type flagellum filament [Term] id: GO:0009422 name: bacterial-type flagellum hook-filament junction namespace: cellular_component def: "The region of the flagellum where the hook and filament meet. Examples of this component are found in bacteria." [GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar hook-filament junction" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009423 name: chorismate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684] subset: gosubset_prok synonym: "chorismate anabolism" EXACT [] synonym: "chorismate biosynthesis" EXACT [] synonym: "chorismate formation" EXACT [] synonym: "chorismate synthesis" EXACT [] xref: MetaCyc:ARO-PWY xref: Reactome:964903 "Chorismate via Shikimate Pathway" is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0009424 name: bacterial-type flagellum hook namespace: cellular_component def: "The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar hook" EXACT [] synonym: "flagellin-based flagellum hook" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009425 name: bacterial-type flagellum basal body namespace: cellular_component def: "One of the three major substructures of the flagellin-based flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring). Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body" BROAD [] synonym: "flagellin-based flagellum basal body" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009426 name: bacterial-type flagellum basal body, distal rod namespace: cellular_component def: "The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, distal rod" EXACT [] synonym: "flagellin-based flagellum basal body, distal rod" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod [Term] id: GO:0009427 name: bacterial-type flagellum basal body, distal rod, L ring namespace: cellular_component def: "One of the rings of the flagellar basal body; anchors the basal body to the outer membrane. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, distal rod, L ring" EXACT [] synonym: "flagellin-based flagellum basal body, distal rod, L ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod [Term] id: GO:0009428 name: bacterial-type flagellum basal body, distal rod, P ring namespace: cellular_component def: "One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, distal rod, P ring" RELATED [] synonym: "flagellin-based flagellum basal body, distal rod, P ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod [Term] id: GO:0009429 name: bacterial-type flagellum basal body, proximal rod namespace: cellular_component def: "The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, proximal rod" EXACT [] synonym: "flagellin-based flagellum basal body, proximal rod" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod [Term] id: GO:0009431 name: bacterial-type flagellum basal body, MS ring namespace: cellular_component alt_id: GO:0009430 def: "One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, mounting plate" BROAD [] synonym: "flagellar basal body, MS ring" EXACT [] synonym: "flagellin-based flagellum basal body, MS ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0009432 name: SOS response namespace: biological_process def: "An error-prone process for repairing damaged microbial DNA." [GOC:jl, PMID:16000023] subset: gosubset_prok xref: Wikipedia:SOS_response is_a: GO:0031668 ! cellular response to extracellular stimulus is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0009433 name: bacterial-type flagellum basal body, C ring namespace: cellular_component def: "Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, C ring" EXACT [] synonym: "flagellin-based flagellum basal body, C ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0009434 name: microtubule-based flagellum namespace: cellular_component def: "A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules." [GOC:mtg_sensu, ISBN:0815316194] comment: See also the cellular component term 'cilium ; GO:0005929'. is_a: GO:0019861 ! flagellum is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0009435 name: NAD biosynthetic process namespace: biological_process alt_id: GO:0006736 def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] subset: gosubset_prok synonym: "NAD (oxidized) biosynthesis" EXACT [] synonym: "NAD (oxidized) biosynthetic process" EXACT [] synonym: "NAD (reduced) biosynthesis" EXACT [] synonym: "NAD (reduced) biosynthetic process" EXACT [] synonym: "NAD anabolism" EXACT [] synonym: "NAD biosynthesis" EXACT [] synonym: "NAD formation" EXACT [] synonym: "NAD synthesis" EXACT [] synonym: "NADH biosynthesis" EXACT [] synonym: "NADH biosynthetic process" EXACT [] synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "nicotinamide adenine dinucleotide biosynthetic process" EXACT [] synonym: "oxidized NAD biosynthesis" EXACT [] synonym: "oxidized NAD biosynthetic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide biosynthetic process" EXACT [] synonym: "reduced NAD biosynthesis" EXACT [] synonym: "reduced NAD biosynthetic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide biosynthetic process" EXACT [] is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process is_a: GO:0019674 ! NAD metabolic process [Term] id: GO:0009436 name: glyoxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glyoxylate breakdown" EXACT [] synonym: "glyoxylate catabolism" EXACT [] synonym: "glyoxylate degradation" EXACT [] xref: MetaCyc:GLYOXDEG-PWY is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046487 ! glyoxylate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0009437 name: carnitine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "carnitine metabolism" EXACT [] synonym: "vitamin Bt metabolic process" EXACT [] synonym: "vitamin Bt metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006577 ! betaine metabolic process [Term] id: GO:0009438 name: methylglyoxal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [CHEBI:17158, GOC:ai] subset: gosubset_prok synonym: "methylglyoxal bypass" NARROW [] synonym: "methylglyoxal metabolism" EXACT [] synonym: "methylglyoxal pathway" NARROW [] xref: MetaCyc:METHGLYUT-PWY is_a: GO:0006081 ! cellular aldehyde metabolic process [Term] id: GO:0009439 name: cyanate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyanate metabolism" EXACT [] xref: MetaCyc:CYANCAT-PWY is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0009440 name: cyanate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyanate breakdown" EXACT [] synonym: "cyanate catabolism" EXACT [] synonym: "cyanate degradation" EXACT [] is_a: GO:0009439 ! cyanate metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0009441 name: glycolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycolate metabolism" EXACT [] xref: MetaCyc:GLYCOLATEMET-PWY is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0009442 name: allantoin assimilation pathway namespace: biological_process def: "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP." [MetaCyc:PWY0-41] subset: gosubset_prok synonym: "allantoin catabolic process via ureidoglycolate" EXACT [] synonym: "allantoin catabolism via ureidoglycolate" EXACT [] synonym: "allantoin degradation pathway" RELATED [] xref: MetaCyc:PWY0-41 is_a: GO:0000256 ! allantoin catabolic process [Term] id: GO:0009443 name: pyridoxal 5'-phosphate salvage namespace: biological_process def: "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "pyridoxal 5' phosphate salvage" EXACT [] xref: MetaCyc:PLPSAL-PWY is_a: GO:0008615 ! pyridoxine biosynthetic process is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0009444 name: pyruvate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate." [MetaCyc:PYRUVOX-PWY] subset: gosubset_prok xref: MetaCyc:PYRUVOX-PWY xref: Wikipedia:Pyruvate_decarboxylation is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0009445 name: putrescine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine." [GOC:ai] subset: gosubset_prok synonym: "putrescine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0009446 name: putrescine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "putrescine anabolism" EXACT [] synonym: "putrescine biosynthesis" EXACT [] synonym: "putrescine formation" EXACT [] synonym: "putrescine synthesis" EXACT [] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0009445 ! putrescine metabolic process [Term] id: GO:0009447 name: putrescine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine." [GOC:ai] subset: gosubset_prok synonym: "putrescine breakdown" EXACT [] synonym: "putrescine catabolism" EXACT [] synonym: "putrescine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0009445 ! putrescine metabolic process [Term] id: GO:0009448 name: gamma-aminobutyric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. subset: gosubset_prok synonym: "4-aminobutanoate metabolic process" EXACT [] synonym: "4-aminobutanoate metabolism" EXACT [] synonym: "4-aminobutyrate metabolic process" EXACT [] synonym: "4-aminobutyrate metabolism" EXACT [] synonym: "GABA metabolic process" EXACT [] synonym: "GABA metabolism" EXACT [] synonym: "gamma-aminobutyric acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009449 name: gamma-aminobutyric acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'. synonym: "4-aminobutanoate biosynthesis" EXACT [] synonym: "4-aminobutanoate biosynthetic process" EXACT [] synonym: "4-aminobutyrate biosynthesis" EXACT [] synonym: "4-aminobutyrate biosynthetic process" EXACT [] synonym: "GABA biosynthesis" EXACT [] synonym: "GABA biosynthetic process" EXACT [] synonym: "gamma-aminobutyric acid anabolism" EXACT [] synonym: "gamma-aminobutyric acid biosynthesis" EXACT [] synonym: "gamma-aminobutyric acid formation" EXACT [] synonym: "gamma-aminobutyric acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process [Term] id: GO:0009450 name: gamma-aminobutyric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'. subset: gosubset_prok synonym: "4-aminobutanoate catabolic process" EXACT [] synonym: "4-aminobutanoate catabolism" EXACT [] synonym: "4-aminobutyrate catabolic process" EXACT [] synonym: "4-aminobutyrate catabolism" EXACT [] synonym: "GABA catabolic process" EXACT [] synonym: "GABA catabolism" EXACT [] synonym: "gamma-aminobutyric acid breakdown" EXACT [] synonym: "gamma-aminobutyric acid catabolism" EXACT [] synonym: "gamma-aminobutyric acid degradation" EXACT [] xref: MetaCyc:4AMINOBUTMETAB-PWY is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process [Term] id: GO:0009451 name: RNA modification namespace: biological_process alt_id: GO:0016547 def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337 "Modification and Editing of RNA"] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. subset: gosubset_prok synonym: "RNA editing" NARROW [GOC:hjd] xref: Wikipedia:RNA_editing is_a: GO:0016070 ! RNA metabolic process is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0009452 name: RNA capping namespace: biological_process def: "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript." [PMID:9266685] is_a: GO:0006396 ! RNA processing [Term] id: GO:0009453 name: energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423] subset: gosubset_prok synonym: "energytaxis" EXACT [] synonym: "taxis in response to energy source" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0009454 name: aerotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to environmental oxygen." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "taxis in response to atmospheric oxygen" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis [Term] id: GO:0009455 name: redox taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to redox potential." [GOC:jl, PMID:11029423] synonym: "redoxtaxis" EXACT [] synonym: "taxis in response to redox potential" EXACT [] synonym: "taxis in response to redox stimulus" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis is_a: GO:0051775 ! response to redox state [Term] id: GO:0009457 name: flavodoxin namespace: molecular_function def: "OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide." [GOC:kd] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009458 name: cytochrome namespace: molecular_function def: "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0045153 consider: GO:0045154 consider: GO:0045155 consider: GO:0045156 consider: GO:0045157 consider: GO:0045158 [Term] id: GO:0009459 name: cytochrome a namespace: molecular_function def: "OBSOLETE. A cytochrome containing heme a." [GOC:kd] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045154 [Term] id: GO:0009460 name: cytochrome b namespace: molecular_function def: "OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b)." [GOC:kd] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009461 name: cytochrome c namespace: molecular_function def: "OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues." [GOC:kd] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045155 [Term] id: GO:0009462 name: cytochrome d namespace: molecular_function def: "OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes." [GOC:kd, PMID:1655423] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009463 name: cytochrome b/b6 namespace: molecular_function def: "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0009464 name: cytochrome b5 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009465 name: soluble cytochrome b562 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045153 [Term] id: GO:0009466 name: class I cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009467 name: monoheme class I cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009468 name: diheme class I cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009469 name: class II cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009470 name: class IIa cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009471 name: class III cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009472 name: cytochrome c3 (tetraheme) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009473 name: cytochrome c7 (triheme) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009474 name: nonaheme cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009475 name: high-molecular-weight cytochrome c (hexadecaheme) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009476 name: class IV cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009477 name: cytochrome c1 namespace: molecular_function def: "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045153 [Term] id: GO:0009478 name: cytochrome c554 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009479 name: cytochrome f namespace: molecular_function def: "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0009480 name: class IIb cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009481 name: aa3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009482 name: ba3-type cytochrome c oxidase namespace: molecular_function alt_id: GO:0009484 def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009483 name: caa3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009485 name: cbb3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009486 name: cytochrome bo3 ubiquinol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+[periplasmic space]." [MetaCyc:RXN0-5268] xref: EC:1.10.3.- xref: MetaCyc:RXN0-5268 is_a: GO:0015002 ! heme-copper terminal oxidase activity [Term] id: GO:0009487 name: glutaredoxin namespace: molecular_function def: "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:kd] comment: This term was made obsolete because it represent a gene product. is_obsolete: true consider: GO:0006467 consider: GO:0015036 consider: GO:0015038 [Term] id: GO:0009488 name: amicyanin namespace: molecular_function def: "OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c." [PMID:1655423] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009489 name: rubredoxin namespace: molecular_function def: "OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues." [GOC:kd] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009490 name: mononuclear iron electron carrier namespace: molecular_function def: "OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009491 name: redox-active disulfide bond electron carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "redox-active disulphide bond electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009492 name: 2Fe-2S electron transfer carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009493 name: adrenodoxin-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009494 name: chloroplast-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009495 name: thioredoxin-like 2Fe-2S ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009496 name: plastoquinol-plastocyanin reductase activity namespace: molecular_function def: "Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin." [EC:1.10.99.1] subset: gosubset_prok synonym: "cytochrome b6f" NARROW [EC:1.10.99.1] synonym: "plastoquinol/plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] xref: EC:1.10.99.1 xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0009497 name: 3Fe-4S/4Fe-4S electron transfer carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009498 name: bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009499 name: monocluster bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009500 name: dicluster bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009501 name: amyloplast namespace: cellular_component def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031] xref: Wikipedia:Amyloplast is_a: GO:0009536 ! plastid [Term] id: GO:0009502 name: photosynthetic electron transport chain namespace: cellular_component def: "OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [GOC:mtg_electron_transport, ISBN:014051403] comment: This term was made obsolete because it represents a process. is_obsolete: true consider: GO:0009767 [Term] id: GO:0009503 name: thylakoid light-harvesting complex namespace: cellular_component def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0030076 ! light-harvesting complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009535 ! chloroplast thylakoid membrane [Term] id: GO:0009504 name: cell plate namespace: cellular_component def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684] xref: Wikipedia:Cell_plate is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009505 name: plant-type cell wall namespace: cellular_component def: "A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances." [ISBN:0471245208] synonym: "cellulose and pectin-containing cell wall" EXACT [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009506 name: plasmodesma namespace: cellular_component def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "plasmodesmata" EXACT [] xref: Wikipedia:Plasmodesma is_a: GO:0005911 ! cell-cell junction relationship: part_of GO:0055044 ! symplast [Term] id: GO:0009507 name: chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] xref: Wikipedia:Chloroplast is_a: GO:0009536 ! plastid [Term] id: GO:0009508 name: plastid chromosome namespace: cellular_component def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943883999] is_a: GO:0000229 ! cytoplasmic chromosome is_a: GO:0044435 ! plastid part relationship: part_of GO:0042646 ! plastid nucleoid [Term] id: GO:0009509 name: chromoplast namespace: cellular_component def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208] xref: Wikipedia:Chromoplast is_a: GO:0009536 ! plastid [Term] id: GO:0009510 name: plasmodesmatal desmotubule namespace: cellular_component alt_id: GO:0009572 def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "desmotubule central rod" RELATED [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009511 name: plasmodesmatal endoplasmic reticulum namespace: cellular_component def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai] synonym: "plasmodesmatal ER" EXACT [] is_a: GO:0005783 ! endoplasmic reticulum is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009510 ! plasmodesmatal desmotubule [Term] id: GO:0009512 name: cytochrome b6f complex namespace: cellular_component def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943883999, PMID:16228398, PMID:16352458] subset: gosubset_prok synonym: "cyt b(6)f complex" EXACT [] synonym: "cyt b6-f complex" EXACT [] synonym: "cyt b6/f complex" EXACT [] synonym: "cyt b6f complex" EXACT [] synonym: "cytochrome b(6)f complex" EXACT [] synonym: "cytochrome b6-f complex" EXACT [] synonym: "cytochrome b6/f complex" EXACT [] xref: Wikipedia:Cytochrome_b6f_complex is_a: GO:0043234 ! protein complex is_a: GO:0044436 ! thylakoid part [Term] id: GO:0009513 name: etioplast namespace: cellular_component def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943883999] xref: Wikipedia:Etioplast is_a: GO:0009536 ! plastid [Term] id: GO:0009514 name: glyoxysome namespace: cellular_component def: "A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds." [GOC:dhl, ISBN:0140514031] xref: Wikipedia:Glyoxysome is_a: GO:0005777 ! peroxisome [Term] id: GO:0009515 name: granal stacked thylakoid namespace: cellular_component def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr] synonym: "chloroplast stacked thylakoid" EXACT [] is_a: GO:0009534 ! chloroplast thylakoid relationship: part_of GO:0009542 ! granum [Term] id: GO:0009516 name: leucoplast namespace: cellular_component def: "A colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943883999] xref: Wikipedia:Leucoplast is_a: GO:0009536 ! plastid [Term] id: GO:0009517 name: PSII associated light-harvesting complex II namespace: cellular_component def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089] synonym: "LHCII" EXACT [] is_a: GO:0009503 ! thylakoid light-harvesting complex [Term] id: GO:0009518 name: PSI associated light-harvesting complex I namespace: cellular_component def: "Protein-pigment complex associated with photosystem I." [GOC:lr] synonym: "LHCI" EXACT [] is_a: GO:0009503 ! thylakoid light-harvesting complex [Term] id: GO:0009519 name: middle lamella namespace: cellular_component def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208] xref: Wikipedia:Middle_lamella is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0009521 name: photosystem namespace: cellular_component alt_id: GO:0030090 def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] subset: goslim_pir subset: gosubset_prok synonym: "reaction center" NARROW [] synonym: "reaction centre" NARROW [] xref: Wikipedia:Photosystem is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0034357 ! photosynthetic membrane [Term] id: GO:0009522 name: photosystem I namespace: cellular_component def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] subset: gosubset_prok is_a: GO:0009521 ! photosystem [Term] id: GO:0009523 name: photosystem II namespace: cellular_component def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949] subset: gosubset_prok xref: Wikipedia:Photosystem_II is_a: GO:0009521 ! photosystem [Term] id: GO:0009524 name: phragmoplast namespace: cellular_component def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208] xref: Wikipedia:Phragmoplast is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009525 name: phragmosome namespace: cellular_component def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943883999] xref: Wikipedia:Phragmosome is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009526 name: plastid envelope namespace: cellular_component def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] is_a: GO:0031967 ! organelle envelope is_a: GO:0044435 ! plastid part [Term] id: GO:0009527 name: plastid outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr] is_a: GO:0031968 ! organelle outer membrane is_a: GO:0042170 ! plastid membrane [Term] id: GO:0009528 name: plastid inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr] is_a: GO:0019866 ! organelle inner membrane is_a: GO:0042170 ! plastid membrane [Term] id: GO:0009529 name: plastid intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr] synonym: "plastid envelope lumen" EXACT [] is_a: GO:0031970 ! organelle envelope lumen is_a: GO:0044435 ! plastid part relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0009530 name: primary cell wall namespace: cellular_component def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jid, PMID:9442872] is_a: GO:0009505 ! plant-type cell wall is_a: GO:0048196 ! middle lamella-containing extracellular matrix [Term] id: GO:0009531 name: secondary cell wall namespace: cellular_component def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jid, ISBN:0943088399] xref: Wikipedia:Secondary_cell_wall is_a: GO:0009505 ! plant-type cell wall is_a: GO:0048196 ! middle lamella-containing extracellular matrix [Term] id: GO:0009532 name: plastid stroma namespace: cellular_component def: "The proteinaceous ground substance of plastids." [ISBN:047142520] is_a: GO:0044435 ! plastid part [Term] id: GO:0009533 name: chloroplast stromal thylakoid namespace: cellular_component def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943883999] is_a: GO:0009534 ! chloroplast thylakoid relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009534 name: chloroplast thylakoid namespace: cellular_component def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943883999] is_a: GO:0031976 ! plastid thylakoid is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009535 name: chloroplast thylakoid membrane namespace: cellular_component def: "The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] is_a: GO:0044434 ! chloroplast part is_a: GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0009534 ! chloroplast thylakoid [Term] id: GO:0009536 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Plastid is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009537 name: proplastid namespace: cellular_component def: "The precursor of other plastids." [ISBN:0943883999] is_a: GO:0009536 ! plastid [Term] id: GO:0009538 name: photosystem I reaction center namespace: cellular_component def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399] subset: gosubset_prok synonym: "photosystem I reaction centre" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009522 ! photosystem I [Term] id: GO:0009539 name: photosystem II reaction center namespace: cellular_component def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399] subset: gosubset_prok synonym: "photosystem II reaction centre" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009540 name: zeaxanthin epoxidase [overall] activity namespace: molecular_function def: "Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O; and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O." [EC:1.14.13.90] comment: This is a process composed of two reactions represented by the terms 'GO:0052662 : zeaxanthin epoxidase activity' and 'GO:0052663 : antheraxanthin epoxidase activity'. synonym: "zea-epoxidase activity" RELATED [EC:1.14.13.90] synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.14.13.90] xref: EC:1.14.13.90 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0009541 name: etioplast prolamellar body namespace: cellular_component def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031] is_a: GO:0044435 ! plastid part relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0009542 name: granum namespace: cellular_component def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:014051403] is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009543 name: chloroplast thylakoid lumen namespace: cellular_component def: "The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:006501037] is_a: GO:0031978 ! plastid thylakoid lumen is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009534 ! chloroplast thylakoid [Term] id: GO:0009544 name: chloroplast ATP synthase complex namespace: cellular_component def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:019854768] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009535 ! chloroplast thylakoid membrane [Term] id: GO:0009545 name: elaioplast namespace: cellular_component def: "A leucoplast in which oil is stored." [ISBN:0140514031] xref: Wikipedia:Elaioplast is_a: GO:0009536 ! plastid [Term] id: GO:0009546 name: plasmodesmatal cytoplasmic sleeve namespace: cellular_component def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "plasmodesmatal cytoplasmic annulus" EXACT [] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009547 name: plastid ribosome namespace: cellular_component def: "A ribosome contained within a plastid." [GOC:tair_curators] is_a: GO:0000313 ! organellar ribosome is_a: GO:0044435 ! plastid part relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0009548 name: plasmodesmatal plasma membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009549 name: cellulose microfibril namespace: cellular_component def: "Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls where it is found as microfibrils laid down in orthogonal layers. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell." [GOC:jid, ISBN:0943088399] is_a: GO:0001527 ! microfibril is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009530 ! primary cell wall relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0009550 name: primary plasmodesma namespace: cellular_component def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255] synonym: "simple plasmodesma" EXACT [] is_a: GO:0009506 ! plasmodesma [Term] id: GO:0009551 name: secondary plasmodesma namespace: cellular_component def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255] is_a: GO:0009506 ! plasmodesma [Term] id: GO:0009553 name: embryo sac development namespace: biological_process alt_id: GO:0048230 def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate." [GOC:mtg_plant, GOC:tb] synonym: "female gametophyte development" EXACT [] is_a: GO:0048229 ! gametophyte development [Term] id: GO:0009554 name: megasporogenesis namespace: biological_process def: "The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb] synonym: "megaspore development" EXACT [] synonym: "megaspore mother cell meiosis" EXACT [] synonym: "meiosis of the megasporocyte" EXACT [] synonym: "meiotic division of the megasporocyte" EXACT [] is_a: GO:0048236 ! plant-type spore development relationship: part_of GO:0009553 ! embryo sac development [Term] id: GO:0009555 name: pollen development namespace: biological_process alt_id: GO:0009564 alt_id: GO:0048231 def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates." [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb] synonym: "formation of generative and vegetative cells" EXACT [] synonym: "male gametophyte development" EXACT [] synonym: "male gametophyte formation" EXACT [] synonym: "microgametophyte development" EXACT [] synonym: "pollen grain formation" EXACT [] is_a: GO:0048229 ! gametophyte development [Term] id: GO:0009556 name: microsporogenesis namespace: biological_process def: "The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb] synonym: "microspore development" EXACT systematic_synonym [] is_a: GO:0048236 ! plant-type spore development relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0009557 name: antipodal cell differentiation namespace: biological_process def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell." [GOC:jid, GOC:mtg_plant] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009558 name: embryo sac cellularization namespace: biological_process alt_id: GO:0009797 def: "The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X] synonym: "cellularization of the embryo sac" EXACT [GOC:curators] synonym: "female gametophyte cellularization" EXACT [] synonym: "megagametophyte cellularization" EXACT [] is_a: GO:0007349 ! cellularization relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009559 name: embryo sac central cell differentiation namespace: biological_process def: "The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell." [GOC:jid, GOC:mtg_plant] synonym: "embryo sac endosperm mother cell differentiation" EXACT [] synonym: "female gametophyte central cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009560 name: embryo sac egg cell differentiation namespace: biological_process alt_id: GO:0048233 def: "The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu] synonym: "female gamete generation" BROAD [] synonym: "female gametophyte egg cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007292 ! female gamete generation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009561 name: megagametogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jl, GOC:mtg_plant] synonym: "embryo sac development from the megaspore" EXACT systematic_synonym [] synonym: "megagametophyte nucleus division" EXACT [] xref: Wikipedia:Megagametogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0009553 ! embryo sac development [Term] id: GO:0009562 name: embryo sac nuclear migration namespace: biological_process def: "The directed movement of an embryo sac nucleus to the pole or center of the cell." [GOC:jl, GOC:mtg_plant] synonym: "embryo sac nucleus migration" EXACT [] synonym: "female gametophyte nuclear migration" EXACT [] synonym: "female gametophyte nucleus migration" EXACT [] synonym: "megagametophyte nuclear migration" EXACT [] synonym: "megagametophyte nucleus migration" EXACT [] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009563 name: synergid differentiation namespace: biological_process def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell." [GOC:jid] synonym: "synergid cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009566 name: fertilization namespace: biological_process def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Fertilisation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0009567 name: double fertilization forming a zygote and endosperm namespace: biological_process def: "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "double fertilization" EXACT [] is_a: GO:0009566 ! fertilization [Term] id: GO:0009568 name: amyloplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] synonym: "amyloplast starch granule" EXACT [] is_a: GO:0043036 ! starch grain relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0009569 name: chloroplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "chloroplast starch granule" EXACT [] is_a: GO:0043036 ! starch grain is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009570 name: chloroplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] is_a: GO:0009532 ! plastid stroma is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009571 name: proplastid stroma namespace: cellular_component def: "The space enclosed by the double membrane of a proplastid." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009537 ! proplastid [Term] id: GO:0009573 name: chloroplast ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana." [GOC:mlg, GOC:mtg_sensu] synonym: "chloroplast RubisCO complex" EXACT [] is_a: GO:0044434 ! chloroplast part is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009574 name: preprophase band namespace: cellular_component def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Preprophase_band is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0009575 name: chromoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009509 ! chromoplast [Term] id: GO:0009576 name: leucoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009516 ! leucoplast [Term] id: GO:0009577 name: elaioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009545 ! elaioplast [Term] id: GO:0009578 name: etioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0009579 name: thylakoid namespace: cellular_component def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles. subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "photosynthetic membrane" RELATED [] xref: Wikipedia:Thylakoid is_a: GO:0044424 ! intracellular part [Term] id: GO:0009580 name: thylakoid (sensu Bacteria) namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific children exist. is_obsolete: true consider: GO:0030075 consider: GO:0042716 [Term] id: GO:0009581 name: detection of external stimulus namespace: biological_process def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] subset: gosubset_prok synonym: "perception of external stimulus" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus namespace: biological_process def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] subset: gosubset_prok synonym: "perception of abiotic stimulus" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus namespace: biological_process def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] subset: gosubset_prok synonym: "detection of light" EXACT [] synonym: "perception of light" RELATED [] is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light namespace: biological_process def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "perception of visible light" RELATED [] is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009585 name: red, far-red light phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm." [GOC:mah] subset: gosubset_prok synonym: "phytochrome signaling pathway" BROAD [] synonym: "red-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction relationship: part_of GO:0010017 ! red or far-red light signaling pathway [Term] id: GO:0009586 name: rhodopsin mediated phototransduction namespace: biological_process def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events then required to return the rhodopsin containing cell to the unexcited state." [GOC:hb] is_a: GO:0007603 ! phototransduction, visible light is_a: GO:0050908 ! detection of light stimulus involved in visual perception [Term] id: GO:0009587 name: phototrophin mediated phototransduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] is_obsolete: true replaced_by: GO:0007602 [Term] id: GO:0009588 name: UV-A, blue light phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of approximately 400-500 nm." [GOC:mah] synonym: "blue-sensitive opsin" RELATED [] synonym: "short-wave-sensitive opsin" RELATED [] synonym: "violet-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction [Term] id: GO:0009589 name: detection of UV namespace: biological_process def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received by a cell and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:go_curators, GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "detection of ultraviolet light stimulus" EXACT [] synonym: "detection of ultraviolet radiation stimulus" EXACT [] synonym: "detection of UV light stimulus" EXACT [] synonym: "detection of UV radiation stimulus" EXACT [] synonym: "perception of UV" RELATED [] is_a: GO:0009411 ! response to UV is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009590 name: detection of gravity namespace: biological_process def: "The series of events in which a gravitational stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of gravity" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009629 ! response to gravity [Term] id: GO:0009591 name: perception of mechanical stimulus namespace: biological_process alt_id: GO:0007609 def: "OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:hb] comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. is_obsolete: true consider: GO:0050954 [Term] id: GO:0009593 name: detection of chemical stimulus namespace: biological_process def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "chemoperception" EXACT [] synonym: "detection of chemical substance" EXACT [] synonym: "perception of chemical stimulus" RELATED [] synonym: "perception of chemical substance" RELATED [] is_a: GO:0042221 ! response to chemical stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009594 name: detection of nutrient namespace: biological_process def: "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "detection of nutrients" EXACT [] synonym: "nutrient sensing" RELATED [] synonym: "perception of nutrients" RELATED [] is_a: GO:0007584 ! response to nutrient is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0009595 name: detection of biotic stimulus namespace: biological_process alt_id: GO:0009596 def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb] subset: gosubset_prok synonym: "perception of biotic stimulus" RELATED [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009597 name: detection of virus namespace: biological_process def: "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb] subset: gosubset_prok synonym: "perception of virus" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009615 ! response to virus [Term] id: GO:0009600 name: detection of nematode namespace: biological_process def: "The series of events in which a stimulus from a nematode is received and converted into a molecular signal." [GOC:hb] synonym: "perception of nematode" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009624 ! response to nematode [Term] id: GO:0009601 name: detection of insect namespace: biological_process def: "The series of events in which a stimulus from an insect is received and converted into a molecular signal." [GOC:hb] synonym: "perception of insect" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009625 ! response to insect [Term] id: GO:0009602 name: detection of symbiont namespace: biological_process def: "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "perception of symbiont" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009608 ! response to symbiont [Term] id: GO:0009603 name: detection of symbiotic fungus namespace: biological_process def: "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "detection of symbiotic fungi" EXACT [] synonym: "perception of symbiotic fungi" RELATED [] synonym: "perception of symbiotic fungus" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009610 ! response to symbiotic fungus is_a: GO:0016046 ! detection of fungus [Term] id: GO:0009604 name: detection of symbiotic bacterium namespace: biological_process def: "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "detection of symbiotic bacteria" EXACT [] synonym: "perception of symbiotic bacteria" RELATED [] synonym: "perception of symbiotic bacterium" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009609 ! response to symbiotic bacterium is_a: GO:0016045 ! detection of bacterium [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: goslim_plant subset: gosubset_prok subset: high_level_annotation_qc synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009606 name: tropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it." [GOC:curators, ISBN:0877795088] subset: goslim_plant xref: Wikipedia:Tropism is_a: GO:0009605 ! response to external stimulus is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: goslim_plant subset: gosubset_prok subset: high_level_annotation_qc synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009608 name: response to symbiont namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response of host to symbiont" RELATED [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009609 name: response to symbiotic bacterium namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response to symbiotic bacteria" EXACT [] is_a: GO:0009608 ! response to symbiont is_a: GO:0009617 ! response to bacterium [Term] id: GO:0009610 name: response to symbiotic fungus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response to symbiotic fungi" EXACT [] is_a: GO:0009608 ! response to symbiont is_a: GO:0009620 ! response to fungus [Term] id: GO:0009611 name: response to wounding namespace: biological_process alt_id: GO:0002245 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] synonym: "physiological response to wounding" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0009612 name: response to mechanical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] subset: gosubset_prok synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanical stimulus response" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009614 name: disease resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0051707 [Term] id: GO:0009615 name: response to virus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb] subset: gosubset_prok synonym: "response to viruses" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009616 name: virus induced gene silencing namespace: biological_process def: "Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes." [GOC:jl] synonym: "VIGS" EXACT [] synonym: "virus-induced gene silencing" EXACT [] is_a: GO:0045087 ! innate immune response is_a: GO:0051607 ! defense response to virus is_a: GO:0052018 ! modulation by symbiont of RNA levels in host [Term] id: GO:0009617 name: response to bacterium namespace: biological_process alt_id: GO:0009618 alt_id: GO:0009680 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] subset: gosubset_prok synonym: "response to bacteria" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009619 name: resistance to pathogenic bacteria namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0009617 [Term] id: GO:0009620 name: response to fungus namespace: biological_process alt_id: GO:0009621 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] synonym: "response to fungi" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009622 name: resistance to pathogenic fungi namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0009620 [Term] id: GO:0009623 name: response to parasitic fungus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic fungus, a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response to parasitic fungi" EXACT [] is_a: GO:0009610 ! response to symbiotic fungus [Term] id: GO:0009624 name: response to nematode namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode." [GOC:hb] synonym: "response to nematodes" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009625 name: response to insect namespace: biological_process alt_id: GO:0043019 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect." [GOC:hb] synonym: "response to insects" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009626 name: plant-type hypersensitive response namespace: biological_process def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089] comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. synonym: "HR" EXACT [] synonym: "HR-PCD" EXACT [] synonym: "plant hypersensitive response" EXACT [] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034050 ! host programmed cell death induced by symbiont is_a: GO:0045087 ! innate immune response [Term] id: GO:0009627 name: systemic acquired resistance namespace: biological_process def: "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, ISBN:052143641] synonym: "salicylic acid-dependent systemic resistance" EXACT [] xref: Wikipedia:Systemic_acquired_resistance is_a: GO:0009814 ! defense response, incompatible interaction [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: goslim_plant subset: gosubset_prok subset: high_level_annotation_qc synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009629 name: response to gravity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb] synonym: "response to gravitational stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009630 name: gravitropism namespace: biological_process def: "The orientation of plant parts under the stimulation of gravity." [ISBN:0198547684] synonym: "geotropism" EXACT [] xref: Wikipedia:Gravitropism is_a: GO:0009606 ! tropism is_a: GO:0009629 ! response to gravity [Term] id: GO:0009631 name: cold acclimation namespace: biological_process def: "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] subset: gosubset_prok is_a: GO:0009409 ! response to cold [Term] id: GO:0009632 name: freezing tolerance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. is_obsolete: true consider: GO:0009409 [Term] id: GO:0009633 name: drought tolerance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. is_obsolete: true consider: GO:0009414 consider: GO:0009819 [Term] id: GO:0009634 name: heavy metal sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. is_obsolete: true consider: GO:0010038 [Term] id: GO:0009635 name: response to herbicide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants." [GOC:curators] subset: gosubset_prok synonym: "herbicide susceptibility/resistance" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009636 ! response to toxin [Term] id: GO:0009636 name: response to toxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxin stimulus." [GOC:lr] subset: gosubset_prok synonym: "detoxification response" NARROW [] synonym: "toxin resistance" RELATED [] synonym: "toxin susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0009637 name: response to blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red] synonym: "response to blue light stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009638 name: phototropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it." [GOC:jl, GOC:mtg_far_red, PMID:16870491] xref: Wikipedia:Phototropism is_a: GO:0009606 ! tropism is_a: GO:0009637 ! response to blue light [Term] id: GO:0009639 name: response to red or far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009640 name: photomorphogenesis namespace: biological_process def: "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis." [GOC:lr] synonym: "plant development in response to light" EXACT systematic_synonym [] xref: Wikipedia:Photomorphogenesis is_a: GO:0009639 ! response to red or far red light is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0009641 name: shade avoidance namespace: biological_process def: "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome." [Wikipedia:Shade_avoidance] xref: Wikipedia:Shade_avoidance is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0009642 name: response to light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009643 name: photosynthetic acclimation namespace: biological_process def: "A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light." [GOC:mah, PMID:11069694] synonym: "light acclimatization" EXACT [PMID:11069694] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009644 name: response to high light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009645 name: response to low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009646 name: response to absence of light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009647 name: skotomorphogenesis namespace: biological_process def: "The control of plant growth, development, and differentiation in response to growth in darkness." [http://www.plantphys.net/article.php?ch=t&id=63, PMID:15012288] synonym: "etiolation" RELATED [] is_a: GO:0009646 ! response to absence of light is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0009648 name: photoperiodism namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "response to day length" EXACT [] synonym: "response to night length" EXACT [] synonym: "response to photoperiod" EXACT [] xref: Wikipedia:Photoperiodism is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009649 name: entrainment of circadian clock namespace: biological_process def: "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] synonym: "regulation of circadian rhythm phase" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0042752 ! regulation of circadian rhythm [Term] id: GO:0009650 name: UV protection namespace: biological_process def: "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml] subset: gosubset_prok synonym: "ultraviolet protection" EXACT [] synonym: "ultraviolet resistance" RELATED [] synonym: "ultraviolet tolerance" RELATED [] synonym: "UV resistance" RELATED [] synonym: "UV tolerance" RELATED [] is_a: GO:0009411 ! response to UV [Term] id: GO:0009651 name: response to salt stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] subset: gosubset_prok synonym: "response to ionic osmotic stress" EXACT [] synonym: "salinity response" EXACT [] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0009652 name: thigmotropism namespace: biological_process def: "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it." [GOC:jl, PMID:16153165] xref: Wikipedia:Thigmotropism is_a: GO:0009606 ! tropism is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] subset: goslim_plant subset: gosubset_prok synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0009654 name: oxygen evolving complex namespace: cellular_component def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [InterPro:IPR002683] subset: gosubset_prok xref: Wikipedia:Oxygen_evolving_complex is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009655 name: PSII associated light-harvesting complex II, core complex namespace: cellular_component def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr] subset: gosubset_prok synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II [Term] id: GO:0009656 name: PSII associated light-harvesting complex II, peripheral complex namespace: cellular_component def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II [Term] id: GO:0009657 name: plastid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah] subset: goslim_pir synonym: "plastid organisation" EXACT [GOC:curators] synonym: "plastid organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0009658 name: chloroplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid] synonym: "chloroplast organisation" EXACT [GOC:curators] synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009659 name: leucoplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jid] synonym: "leucoplast organisation" EXACT [GOC:curators] synonym: "leucoplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009660 name: amyloplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch." [GOC:jid] synonym: "amyloplast organisation" EXACT [GOC:curators] synonym: "amyloplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009661 name: chromoplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [GOC:jid] synonym: "chromoplast organisation" EXACT [GOC:curators] synonym: "chromoplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009662 name: etioplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [GOC:jid] synonym: "etioplast organisation" EXACT [GOC:curators] synonym: "etioplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009663 name: plasmodesma organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [GOC:mah] synonym: "plasmodesma organisation" EXACT [GOC:curators] synonym: "plasmodesma organization and biogenesis" RELATED [GOC:curators] synonym: "plasmodesmata organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0009664 name: plant-type cell wall organization namespace: biological_process def: "A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu] synonym: "cell wall organization and biogenesis" NARROW [] synonym: "cellulose and pectin-containing cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "plant-type cell wall organisation" EXACT [GOC:curators] synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007047 ! cellular cell wall organization is_a: GO:0071669 ! plant-type cell wall organization or biogenesis [Term] id: GO:0009665 name: plastid inheritance namespace: biological_process def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah] is_a: GO:0009657 ! plastid organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0009666 name: plastid outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid outer membrane organisation" EXACT [GOC:curators] synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0009667 name: plastid inner membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid inner membrane organisation" EXACT [GOC:curators] synonym: "plastid inner membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0009668 name: plastid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid membrane organisation" EXACT [GOC:curators] synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0009657 ! plastid organization [Term] id: GO:0009669 name: sucrose:monovalent cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1] synonym: "sucrose permease activity" RELATED [] is_a: GO:0008515 ! sucrose transmembrane transporter activity is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity [Term] id: GO:0009670 name: triose-phosphate:phosphate antiporter activity namespace: molecular_function alt_id: GO:0015122 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)." [GOC:bf, GOC:jl, GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-] synonym: "dihydroxyacetone phosphate:phosphate antiporter activity" EXACT [] synonym: "TPT" RELATED [] synonym: "triose phosphate antiporter" EXACT [] synonym: "triose phosphate translocator" EXACT [] is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0071917 ! triose-phosphate transmembrane transporter activity [Term] id: GO:0009671 name: nitrate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [GOC:mah, PMID:10066586, PMID:1990981] synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT [] synonym: "nitrate(chlorate):proton symporter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015112 ! nitrate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0009672 name: auxin:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077] synonym: "auxin:proton symporter activity" EXACT [] is_a: GO:0015294 ! solute:cation symporter activity is_a: GO:0080161 ! auxin transmembrane transporter activity [Term] id: GO:0009673 name: low affinity phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphate from one side of the membrane to the other. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-] is_a: GO:0015114 ! phosphate transmembrane transporter activity [Term] id: GO:0009674 name: potassium:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1] synonym: "high affinity potassium transporter" RELATED [] is_a: GO:0022820 ! potassium ion symporter activity [Term] id: GO:0009675 name: high affinity sulfate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] synonym: "high affinity sulfate:proton symporter activity" EXACT [] synonym: "high affinity sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008512 ! sulfate:hydrogen symporter activity [Term] id: GO:0009676 name: low affinity sulfate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mah, PMID:7568135] synonym: "low affinity sulfate:proton symporter activity" EXACT [] synonym: "low affinity sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008512 ! sulfate:hydrogen symporter activity [Term] id: GO:0009677 name: double fertilization forming two zygotes namespace: biological_process def: "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis." [GOC:mtg_sensu, GOC:tb] is_a: GO:0009566 ! fertilization [Term] id: GO:0009678 name: hydrogen-translocating pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.10.-.-] subset: gosubset_prok synonym: "proton-translocating pyrophosphatase activity" EXACT [] is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0009679 name: hexose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-] subset: gosubset_prok synonym: "hexose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0009682 name: induced systemic resistance namespace: biological_process def: "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273] is_a: GO:0042742 ! defense response to bacterium is_a: GO:0045087 ! innate immune response [Term] id: GO:0009683 name: indoleacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:mah] subset: gosubset_prok synonym: "IAA metabolic process" EXACT [] synonym: "indole acetic acid metabolic process" EXACT [] synonym: "indole acetic acid metabolism" EXACT [] synonym: "indoleacetic acid metabolism" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0009684 name: indoleacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845] subset: gosubset_prok synonym: "IAA biosynthetic process" EXACT [] synonym: "indole acetic acid biosynthesis" EXACT [] synonym: "indole acetic acid biosynthetic process" EXACT [] synonym: "indole-3-acetate biosynthesis" EXACT [] synonym: "indole-3-acetate biosynthetic process" EXACT [] synonym: "indole-acetic acid biosynthesis" EXACT [] synonym: "indole-acetic acid biosynthetic process" RELATED [] synonym: "indoleacetic acid anabolism" EXACT [] synonym: "indoleacetic acid biosynthesis" EXACT [] synonym: "indoleacetic acid formation" EXACT [] synonym: "indoleacetic acid synthesis" EXACT [] is_a: GO:0009683 ! indoleacetic acid metabolic process is_a: GO:0009851 ! auxin biosynthetic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009685 name: gibberellin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] subset: gosubset_prok synonym: "gibberellic acid metabolic process" NARROW [] synonym: "gibberellic acid metabolism" NARROW [] synonym: "gibberellin metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0009686 name: gibberellin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] subset: gosubset_prok synonym: "gibberellic acid anabolism" NARROW [] synonym: "gibberellic acid biosynthesis" NARROW [] synonym: "gibberellic acid biosynthetic process" NARROW [] synonym: "gibberellic acid formation" NARROW [] synonym: "gibberellic acid synthesis" NARROW [] synonym: "gibberellin biosynthesis" EXACT [] xref: MetaCyc:PWY-5035 xref: MetaCyc:PWY-5036 xref: MetaCyc:PWY-5052 xref: MetaCyc:PWY-5070 is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009687 name: abscisic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] subset: gosubset_prok synonym: "abscisic acid metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043288 ! apocarotenoid metabolic process [Term] id: GO:0009688 name: abscisic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] subset: gosubset_prok synonym: "abscisic acid anabolism" EXACT [] synonym: "abscisic acid biosynthesis" EXACT [] synonym: "abscisic acid formation" EXACT [] synonym: "abscisic acid synthesis" EXACT [] xref: MetaCyc:PWY-695 is_a: GO:0009687 ! abscisic acid metabolic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0043289 ! apocarotenoid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009689 name: induction of phytoalexin biosynthetic process namespace: biological_process def: "The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection." [ISBN:0943088399] synonym: "induction of phytoalexin anabolism" EXACT [] synonym: "induction of phytoalexin biosynthesis" EXACT [] synonym: "induction of phytoalexin formation" EXACT [] synonym: "induction of phytoalexin synthesis" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process [Term] id: GO:0009690 name: cytokinin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] subset: gosubset_prok synonym: "cytokinin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009691 name: cytokinin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] subset: gosubset_prok synonym: "cytokinin anabolism" EXACT [] synonym: "cytokinin biosynthesis" EXACT [] synonym: "cytokinin formation" EXACT [] synonym: "cytokinin synthesis" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009692 name: ethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] subset: gosubset_prok synonym: "ethene metabolic process" EXACT [] synonym: "ethene metabolism" EXACT [] synonym: "ethylene metabolism" EXACT [] xref: Reactome:1230015 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:1257792 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:1283420 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:1303847 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:1331307 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:1377226 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:1397458 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1" is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0009693 name: ethylene biosynthetic process namespace: biological_process alt_id: GO:0042456 def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] subset: gosubset_prok synonym: "ethene biosynthesis" EXACT [] synonym: "ethene biosynthesis from L-methionine" EXACT [] synonym: "ethene biosynthetic process" EXACT [] synonym: "ethene biosynthetic process from L-methionine" EXACT [] synonym: "ethylene anabolism" EXACT [] synonym: "ethylene biosynthesis" EXACT [] synonym: "ethylene biosynthesis from L-methionine" EXACT [] synonym: "ethylene biosynthetic process from L-methionine" EXACT [] synonym: "ethylene formation" EXACT [] synonym: "ethylene synthesis" EXACT [] xref: MetaCyc:ETHYL-PWY is_a: GO:0009692 ! ethylene metabolic process is_a: GO:0043450 ! alkene biosynthetic process [Term] id: GO:0009694 name: jasmonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845] subset: gosubset_prok synonym: "jasmonic acid metabolism" EXACT [] is_a: GO:0031407 ! oxylipin metabolic process [Term] id: GO:0009695 name: jasmonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [ISBN:0387969845] synonym: "jasmonic acid anabolism" EXACT [] synonym: "jasmonic acid biosynthesis" EXACT [] synonym: "jasmonic acid formation" EXACT [] synonym: "jasmonic acid synthesis" EXACT [] xref: MetaCyc:PWY-735 is_a: GO:0009694 ! jasmonic acid metabolic process is_a: GO:0031408 ! oxylipin biosynthetic process [Term] id: GO:0009696 name: salicylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] subset: gosubset_prok synonym: "salicylic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0009697 name: salicylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] subset: gosubset_prok synonym: "salicylate biosynthetic process" EXACT [] synonym: "salicylic acid anabolism" EXACT [] synonym: "salicylic acid biosynthesis" EXACT [] synonym: "salicylic acid formation" EXACT [] synonym: "salicylic acid synthesis" EXACT [] xref: MetaCyc:PWY-981 is_a: GO:0009696 ! salicylic acid metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009698 name: phenylpropanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid." [GOC:jl] subset: gosubset_prok synonym: "phenylpropanoid metabolism" EXACT [] xref: MetaCyc:PWY1F-467 is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0009699 name: phenylpropanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid." [GOC:jl] subset: gosubset_prok synonym: "phenylpropanoid anabolism" EXACT [] synonym: "phenylpropanoid biosynthesis" EXACT [] synonym: "phenylpropanoid formation" EXACT [] synonym: "phenylpropanoid synthesis" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process [Term] id: GO:0009700 name: indole phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:sm, ISBN:0198547684] synonym: "indole phytoalexin anabolism" EXACT [] synonym: "indole phytoalexin biosynthesis" EXACT [] synonym: "indole phytoalexin formation" EXACT [] synonym: "indole phytoalexin synthesis" EXACT [] is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046217 ! indole phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009701 name: isoflavonoid phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] synonym: "isoflavonoid phytoalexin anabolism" EXACT [] synonym: "isoflavonoid phytoalexin biosynthesis" EXACT [] synonym: "isoflavonoid phytoalexin formation" EXACT [] synonym: "isoflavonoid phytoalexin synthesis" EXACT [] is_a: GO:0009717 ! isoflavonoid biosynthetic process is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009702 name: L-arabinokinase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.46, RHEA:20156] synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT [] synonym: "L-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.46] xref: EC:2.7.1.46 xref: KEGG:R01754 xref: MetaCyc:L-ARABINOKINASE-RXN xref: RHEA:20156 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0009703 name: nitrate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+." [EC:1.7.1.1] comment: Note that this function was formerly EC:1.6.6.1. synonym: "assimilatory NADH: nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory NADH:nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1] synonym: "NADH-dependent nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH-nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate reductase activity" EXACT [] synonym: "nitrate reductase (NADH(2)) activity" EXACT [EC:1.7.1.1] synonym: "nitrate reductase (NADH2)" EXACT [EC:1.7.1.1] synonym: "nitrite:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.1] xref: EC:1.7.1.1 xref: MetaCyc:NITRATE-REDUCTASE-NADH-RXN is_a: GO:0008940 ! nitrate reductase activity is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0009704 name: de-etiolation namespace: biological_process def: "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll." [GOC:lr] is_a: GO:0009416 ! response to light stimulus relationship: part_of GO:0009640 ! photomorphogenesis [Term] id: GO:0009705 name: plant-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0471245208] synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT [] synonym: "tonoplast" EXACT [] synonym: "vacuolar membrane" BROAD [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0000325 ! plant-type vacuole [Term] id: GO:0009706 name: chloroplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb] synonym: "chloroplast inner envelope" EXACT [] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0031969 ! chloroplast membrane [Term] id: GO:0009707 name: chloroplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb] synonym: "chloroplast outer envelope" EXACT [] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0031969 ! chloroplast membrane [Term] id: GO:0009708 name: benzyl isoquinoline alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "benzyl isoquinoline alkaloid anabolism" EXACT [] synonym: "benzyl isoquinoline alkaloid biosynthesis" EXACT [] synonym: "benzyl isoquinoline alkaloid formation" EXACT [] synonym: "benzyl isoquinoline alkaloid synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process [Term] id: GO:0009709 name: terpenoid indole alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] subset: gosubset_prok synonym: "terpenoid indole alkaloid anabolism" EXACT [] synonym: "terpenoid indole alkaloid biosynthesis" EXACT [] synonym: "terpenoid indole alkaloid formation" EXACT [] synonym: "terpenoid indole alkaloid synthesis" EXACT [] is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process [Term] id: GO:0009710 name: tropane alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "tropane alkaloid anabolism" EXACT [] synonym: "tropane alkaloid biosynthesis" EXACT [] synonym: "tropane alkaloid formation" EXACT [] synonym: "tropane alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046448 ! tropane alkaloid metabolic process [Term] id: GO:0009711 name: purine alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] subset: gosubset_prok synonym: "purine alkaloid anabolism" EXACT [] synonym: "purine alkaloid biosynthesis" EXACT [] synonym: "purine alkaloid formation" EXACT [] synonym: "purine alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0046446 ! purine alkaloid metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0009712 name: catechol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684] subset: gosubset_prok synonym: "catechol metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0034311 ! diol metabolic process [Term] id: GO:0009713 name: catechol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of catechol, a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] subset: gosubset_prok synonym: "catechol anabolism" EXACT [] synonym: "catechol biosynthesis" EXACT [] synonym: "catechol formation" EXACT [] synonym: "catechol synthesis" EXACT [] is_a: GO:0009712 ! catechol metabolic process is_a: GO:0034312 ! diol biosynthetic process [Term] id: GO:0009714 name: chalcone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chalcone metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0009715 name: chalcone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:go_curators] subset: gosubset_prok synonym: "chalcone anabolism" EXACT [] synonym: "chalcone biosynthesis" EXACT [] synonym: "chalcone formation" EXACT [] synonym: "chalcone synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009714 ! chalcone metabolic process is_a: GO:0042181 ! ketone biosynthetic process [Term] id: GO:0009716 name: flavonoid phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "flavonoid phytoalexin anabolism" EXACT [] synonym: "flavonoid phytoalexin biosynthesis" EXACT [] synonym: "flavonoid phytoalexin formation" EXACT [] synonym: "flavonoid phytoalexin synthesis" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046285 ! flavonoid phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009717 name: isoflavonoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] subset: gosubset_prok synonym: "isoflavonoid anabolism" EXACT [] synonym: "isoflavonoid biosynthesis" EXACT [] synonym: "isoflavonoid formation" EXACT [] synonym: "isoflavonoid synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0046287 ! isoflavonoid metabolic process [Term] id: GO:0009718 name: anthocyanin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] subset: gosubset_prok synonym: "anthocyanin anabolism" EXACT [] synonym: "anthocyanin biosynthesis" EXACT [] synonym: "anthocyanin formation" EXACT [] synonym: "anthocyanin synthesis" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0046283 ! anthocyanin metabolic process [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: goslim_plant subset: gosubset_prok subset: high_level_annotation_qc is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009720 name: detection of hormone stimulus namespace: biological_process def: "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of hormone stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009725 ! response to hormone stimulus is_a: GO:0009726 ! detection of endogenous stimulus [Term] id: GO:0009721 name: detection of auxin stimulus namespace: biological_process def: "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of auxin stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009733 ! response to auxin stimulus [Term] id: GO:0009722 name: detection of cytokinin stimulus namespace: biological_process def: "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of cytokinin stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009735 ! response to cytokinin stimulus [Term] id: GO:0009723 name: response to ethylene stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:jl] synonym: "response to ethene stimulus" EXACT [] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009724 name: detection of abscisic acid stimulus namespace: biological_process def: "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of abscisic acid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009737 ! response to abscisic acid stimulus [Term] id: GO:0009725 name: response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] synonym: "growth regulator" RELATED [] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009726 name: detection of endogenous stimulus namespace: biological_process def: "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of endogenous stimulus" RELATED [] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009727 name: detection of ethylene stimulus namespace: biological_process def: "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "detection of ethene stimulus" EXACT [] synonym: "perception of ethene stimulus" RELATED [] synonym: "perception of ethylene stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009723 ! response to ethylene stimulus [Term] id: GO:0009728 name: detection of gibberellic acid stimulus namespace: biological_process def: "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of gibberellic acid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009739 ! response to gibberellin stimulus [Term] id: GO:0009729 name: detection of brassinosteroid stimulus namespace: biological_process def: "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of brassinosteroid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009741 ! response to brassinosteroid stimulus [Term] id: GO:0009730 name: detection of carbohydrate stimulus namespace: biological_process def: "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of carbohydrate stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009743 ! response to carbohydrate stimulus [Term] id: GO:0009731 name: detection of sucrose stimulus namespace: biological_process def: "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of sucrose stimulus" RELATED [] is_a: GO:0009744 ! response to sucrose stimulus is_a: GO:0034288 ! detection of disaccharide stimulus [Term] id: GO:0009732 name: detection of hexose stimulus namespace: biological_process def: "The series of events in which a stimulus from a hexose is received and converted into a molecular signal." [GOC:sm] synonym: "perception of hexose stimulus" RELATED [] is_a: GO:0009746 ! response to hexose stimulus is_a: GO:0034287 ! detection of monosaccharide stimulus [Term] id: GO:0009733 name: response to auxin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:jl] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009734 name: auxin mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated in response to detection of auxin." [GOC:mah, GOC:sm] synonym: "auxin mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0071365 ! cellular response to auxin stimulus [Term] id: GO:0009735 name: response to cytokinin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:jl] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009736 name: cytokinin mediated signaling pathway namespace: biological_process def: "A series of molecular signals induced by the detection of cytokinin." [GOC:sm] synonym: "cytokinin mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0071368 ! cellular response to cytokinin stimulus [Term] id: GO:0009737 name: response to abscisic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009738 name: abscisic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of abscisic acid." [GOC:sm] synonym: "abscisic acid mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0071215 ! cellular response to abscisic acid stimulus [Term] id: GO:0009739 name: response to gibberellin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl] synonym: "response to gibberellic acid stimulus" NARROW [] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009740 name: gibberellic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of gibberellic acid." [GOC:sm] synonym: "GA-signaling" EXACT [] synonym: "gibberellic acid mediated signalling" EXACT [] synonym: "gibberellic acid signaling" EXACT [] is_a: GO:0010476 ! gibberellin mediated signaling pathway is_a: GO:0071370 ! cellular response to gibberellin stimulus [Term] id: GO:0009741 name: response to brassinosteroid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:jl] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009742 name: brassinosteroid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of brassinosteroid." [GOC:sm] synonym: "brassinosteroid mediated signalling" EXACT [] is_a: GO:0043401 ! steroid hormone mediated signaling pathway is_a: GO:0071367 ! cellular response to brassinosteroid stimulus [Term] id: GO:0009743 name: response to carbohydrate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009744 name: response to sucrose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] is_a: GO:0034285 ! response to disaccharide stimulus [Term] id: GO:0009745 name: sucrose mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of sucrose." [GOC:sm] synonym: "sucrose mediated signalling" EXACT [] is_a: GO:0010182 ! sugar mediated signaling pathway is_a: GO:0071329 ! cellular response to sucrose stimulus [Term] id: GO:0009746 name: response to hexose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] is_a: GO:0034284 ! response to monosaccharide stimulus [Term] id: GO:0009747 name: hexokinase-dependent signaling namespace: biological_process def: "A series of molecular signals mediated by hexose and dependent on the detection of hexokinase." [GOC:mah, GOC:sm] synonym: "hexokinase-dependent signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling [Term] id: GO:0009748 name: hexokinase-independent signaling namespace: biological_process def: "A series of molecular signals mediated by hexose and independent of hexokinase." [GOC:mah, GOC:sm] synonym: "hexokinase-independent signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling [Term] id: GO:0009749 name: response to glucose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] is_a: GO:0009746 ! response to hexose stimulus [Term] id: GO:0009750 name: response to fructose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl] is_a: GO:0009746 ! response to hexose stimulus [Term] id: GO:0009751 name: response to salicylic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009752 name: detection of salicylic acid stimulus namespace: biological_process def: "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of salicylic acid stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009751 ! response to salicylic acid stimulus [Term] id: GO:0009753 name: response to jasmonic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009754 name: detection of jasmonic acid stimulus namespace: biological_process def: "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule." [GOC:sm] synonym: "perception of jasmonic acid stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009726 ! detection of endogenous stimulus is_a: GO:0009753 ! response to jasmonic acid stimulus [Term] id: GO:0009755 name: hormone-mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] synonym: "hormone mediated signalling" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0009756 name: carbohydrate mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of carbohydrate." [GOC:sm] synonym: "carbohydrate mediated signalling" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071322 ! cellular response to carbohydrate stimulus [Term] id: GO:0009757 name: hexose mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of hexose." [GOC:sm] synonym: "hexose mediated signalling" EXACT [] is_a: GO:0010182 ! sugar mediated signaling pathway is_a: GO:0071331 ! cellular response to hexose stimulus [Term] id: GO:0009758 name: carbohydrate utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] is_a: GO:0008150 ! biological_process [Term] id: GO:0009759 name: indole glucosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [GOC:ai] subset: gosubset_prok synonym: "indole glucosinolate anabolism" EXACT [] synonym: "indole glucosinolate biosynthesis" EXACT [] synonym: "indole glucosinolate formation" EXACT [] synonym: "indole glucosinolate synthesis" EXACT [] xref: MetaCyc:PWY-601 is_a: GO:0019761 ! glucosinolate biosynthetic process is_a: GO:0042343 ! indole glucosinolate metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process [Term] id: GO:0009760 name: C4 photosynthesis namespace: biological_process def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch." [ISBN:0816017360] xref: Wikipedia:C4_carbon_fixation is_a: GO:0015977 ! carbon fixation is_a: GO:0019685 ! photosynthesis, dark reaction is_a: GO:0044236 ! multicellular organismal metabolic process [Term] id: GO:0009761 name: CAM photosynthesis namespace: biological_process def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis." [ISBN:0582015952] xref: Wikipedia:Crassulacean_acid_metabolism is_a: GO:0015977 ! carbon fixation is_a: GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0009762 name: NADP-malic enzyme C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme." [PMID:11788762] xref: MetaCyc:PWY-241 is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009763 name: NAD-malic enzyme C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme." [PMID:11788762] is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009764 name: PEP carboxykinase C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK)." [PMID:11788762] is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009765 name: photosynthesis, light harvesting namespace: biological_process def: "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers." [GOC:sm] synonym: "energy dissipation" RELATED [] is_a: GO:0006091 ! generation of precursor metabolites and energy relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009766 name: primary charge separation namespace: biological_process def: "In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes." [ISBN:0792361431] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009767 name: photosynthetic electron transport chain namespace: biological_process alt_id: GO:0009774 alt_id: GO:0009775 alt_id: GO:0009776 def: "A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0198547684] synonym: "electron carrier, chlorophyll electron transport system" EXACT [] synonym: "photosynthetic electron transport in cytochrome b6/f" NARROW [] synonym: "photosynthetic electron transport in plastocyanin" NARROW [] synonym: "photosynthetic electron transport in plastoquinone" NARROW [] is_a: GO:0022900 ! electron transport chain relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009768 name: photosynthesis, light harvesting in photosystem I namespace: biological_process def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0009769 name: photosynthesis, light harvesting in photosystem II namespace: biological_process def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0009770 name: primary charge separation in photosystem I namespace: biological_process def: "Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009766 ! primary charge separation [Term] id: GO:0009771 name: primary charge separation in photosystem II namespace: biological_process def: "Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009766 ! primary charge separation [Term] id: GO:0009772 name: photosynthetic electron transport in photosystem II namespace: biological_process def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009773 name: photosynthetic electron transport in photosystem I namespace: biological_process def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009777 name: photosynthetic phosphorylation namespace: biological_process def: "Any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation." [ISBN:0198547684] synonym: "photosynthetic ATP synthesis" NARROW [] is_a: GO:0016310 ! phosphorylation relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009778 name: cyclic photosynthetic phosphorylation namespace: biological_process def: "A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I." [ISBN:0198547684] is_a: GO:0009777 ! photosynthetic phosphorylation [Term] id: GO:0009779 name: noncyclic photosynthetic phosphorylation namespace: biological_process def: "A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II." [ISBN:0198547684] is_a: GO:0009777 ! photosynthetic phosphorylation [Term] id: GO:0009780 name: photosynthetic NADP+ reduction namespace: biological_process def: "An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions." [GOC:jid, ISBN:0716746840, ISBN:0816017360] is_a: GO:0006740 ! NADPH regeneration relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009781 name: photosynthetic water oxidation namespace: biological_process def: "OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:jid, ISBN:0716743663, ISBN:0816017360] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0010242 [Term] id: GO:0009782 name: photosystem I antenna complex namespace: cellular_component def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009522 ! photosystem I [Term] id: GO:0009783 name: photosystem II antenna complex namespace: cellular_component def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009784 name: transmembrane receptor histidine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah] subset: gosubset_prok is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0009785 name: blue light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm] synonym: "blue light signalling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor mediated signaling pathway is_a: GO:0071483 ! cellular response to blue light [Term] id: GO:0009786 name: regulation of asymmetric cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] is_a: GO:0051302 ! regulation of cell division relationship: regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0009787 name: regulation of abscisic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by abscisic acid." [GOC:lr] synonym: "regulation of abscisic acid mediated signalling" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0009738 ! abscisic acid mediated signaling pathway [Term] id: GO:0009788 name: negative regulation of abscisic acid mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by abscisic acid." [GOC:lr] synonym: "down regulation of abscisic acid mediated signaling" EXACT [] synonym: "down-regulation of abscisic acid mediated signaling" EXACT [] synonym: "downregulation of abscisic acid mediated signaling" EXACT [] synonym: "inhibition of abscisic acid mediated signaling" NARROW [] synonym: "negative regulation of abscisic acid mediated signalling" EXACT [] is_a: GO:0009787 ! regulation of abscisic acid mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0009738 ! abscisic acid mediated signaling pathway [Term] id: GO:0009789 name: positive regulation of abscisic acid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of abscisic acid mediated signal transduction." [GOC:lr] synonym: "activation of abscisic acid mediated signaling" NARROW [] synonym: "positive regulation of abscisic acid mediated signalling" EXACT [] synonym: "stimulation of abscisic acid mediated signaling" NARROW [] synonym: "up regulation of abscisic acid mediated signaling" EXACT [] synonym: "up-regulation of abscisic acid mediated signaling" EXACT [] synonym: "upregulation of abscisic acid mediated signaling" EXACT [] is_a: GO:0009787 ! regulation of abscisic acid mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0009738 ! abscisic acid mediated signaling pathway [Term] id: GO:0009790 name: embryo development namespace: biological_process alt_id: GO:0009795 def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: goslim_generic subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Wikipedia:Embryogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0009791 name: post-embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators] subset: goslim_plant is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0009792 name: embryo development ending in birth or egg hatching namespace: biological_process def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0009790 ! embryo development [Term] id: GO:0009793 name: embryo development ending in seed dormancy namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana." [GOC:go_curators, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009790 ! embryo development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0009794 name: regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of embryonic mitotic cell cycle progression" EXACT [] synonym: "embryonic mitotic cell cycle control" EXACT [] synonym: "embryonic mitotic cell cycle modulation" EXACT [] synonym: "embryonic mitotic cell cycle regulation" EXACT [] synonym: "embryonic mitotic cell cycle regulator" RELATED [] synonym: "modulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0009798 name: axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "axis determination" RELATED [] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009799 name: specification of symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators] synonym: "determination of symmetry" EXACT [GOC:dph] synonym: "specification of symmetry" EXACT [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009800 name: cinnamic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] subset: gosubset_prok synonym: "cinnamic acid anabolism" EXACT [] synonym: "cinnamic acid biosynthesis" EXACT [] synonym: "cinnamic acid formation" EXACT [] synonym: "cinnamic acid synthesis" EXACT [] synonym: "cinnamylic acid biosynthesis" EXACT [] synonym: "cinnamylic acid biosynthetic process" EXACT [] synonym: "phenylacrylic acid biosynthesis" EXACT [] synonym: "phenylacrylic acid biosynthetic process" EXACT [] synonym: "phenylpropenoic acid biosynthesis" EXACT [] synonym: "phenylpropenoic acid biosynthetic process" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009803 ! cinnamic acid metabolic process [Term] id: GO:0009801 name: cinnamic acid ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:lr, GOC:yl] subset: gosubset_prok synonym: "cinnamic acid ester metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009802 name: cinnamic acid ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:jl] subset: gosubset_prok synonym: "cinnamic acid ester anabolism" EXACT [] synonym: "cinnamic acid ester biosynthesis" EXACT [] synonym: "cinnamic acid ester formation" EXACT [] synonym: "cinnamic acid ester synthesis" EXACT [] synonym: "cinnamylic acid ester biosynthesis" EXACT [] synonym: "cinnamylic acid ester biosynthetic process" EXACT [] synonym: "phenylacrylic acid ester biosynthesis" EXACT [] synonym: "phenylacrylic acid ester biosynthetic process" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009801 ! cinnamic acid ester metabolic process relationship: part_of GO:0009803 ! cinnamic acid metabolic process [Term] id: GO:0009803 name: cinnamic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] subset: gosubset_prok synonym: "cinnamic acid metabolism" EXACT [] synonym: "cinnamylic acid metabolic process" EXACT [] synonym: "cinnamylic acid metabolism" EXACT [] synonym: "phenylacrylic acid metabolic process" EXACT [] synonym: "phenylacrylic acid metabolism" EXACT [] synonym: "phenylpropenoic acid metabolic process" EXACT [] synonym: "phenylpropenoic acid metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0009804 name: coumarin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] subset: gosubset_prok synonym: "coumarin metabolism" EXACT [] xref: Reactome:1229990 "Coumarin is 7-hydroxylated by CYP2A6" xref: Reactome:1241593 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:1283381 "Coumarin is 7-hydroxylated by CYP2A6" xref: Reactome:1291844 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:1303801 "Coumarin is 7-hydroxylated by CYP2A6" xref: Reactome:1314852 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:1331282 "Coumarin is 7-hydroxylated by CYP2A6" xref: Reactome:1341997 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:1397419 "Coumarin is 7-hydroxylated by CYP2A6" xref: Reactome:1407636 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:1423457 "Coumarin is 7-hydroxylated by CYP2A6" xref: Reactome:1437314 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:211881 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:76453 "Coumarin is 7-hydroxylated by CYP2A6" is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009805 name: coumarin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] subset: gosubset_prok synonym: "coumarin anabolism" EXACT [] synonym: "coumarin biosynthesis" EXACT [] synonym: "coumarin formation" EXACT [] synonym: "coumarin synthesis" EXACT [] xref: MetaCyc:PWY-5176 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009804 ! coumarin metabolic process [Term] id: GO:0009806 name: lignan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] subset: gosubset_prok synonym: "lignan metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009807 name: lignan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] subset: gosubset_prok synonym: "lignan anabolism" EXACT [] synonym: "lignan biosynthesis" EXACT [] synonym: "lignan formation" EXACT [] synonym: "lignan synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009806 ! lignan metabolic process [Term] id: GO:0009808 name: lignin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units." [GOC:lr, GOC:yl] subset: gosubset_prok synonym: "lignin metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009809 name: lignin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GOC:tair_curators, ISBN:0198547684] subset: gosubset_prok synonym: "lignin anabolism" EXACT [] synonym: "lignin biosynthesis" EXACT [] synonym: "lignin formation" EXACT [] synonym: "lignin synthesis" EXACT [] xref: MetaCyc:PWY-361 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009808 ! lignin metabolic process [Term] id: GO:0009810 name: stilbene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA." [ISBN:311011625] subset: gosubset_prok synonym: "stilbene metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0030638 ! polyketide metabolic process [Term] id: GO:0009811 name: stilbene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:tair_curators, ISBN:3110116251] subset: gosubset_prok synonym: "stilbene anabolism" EXACT [] synonym: "stilbene biosynthesis" EXACT [] synonym: "stilbene formation" EXACT [] synonym: "stilbene synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009810 ! stilbene metabolic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0043450 ! alkene biosynthetic process [Term] id: GO:0009812 name: flavonoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins." [GOC:tair_curators, ISBN:0198547684] subset: gosubset_prok synonym: "flavonoid metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009813 name: flavonoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:tair_curators, ISBN:0198547684] subset: gosubset_prok synonym: "flavonoid anabolism" EXACT [] synonym: "flavonoid biosynthesis" EXACT [] synonym: "flavonoid formation" EXACT [] synonym: "flavonoid synthesis" EXACT [] xref: MetaCyc:PWY1F-FLAVSYN xref: Wikipedia:Flavonoid is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009812 ! flavonoid metabolic process [Term] id: GO:0009814 name: defense response, incompatible interaction namespace: biological_process def: "A response of a plant to a pathogenic agent that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response incompatible interaction" EXACT [] synonym: "defence response to pathogen, incompatible interaction" EXACT [] synonym: "resistance response to pathogen" EXACT [] synonym: "response to pathogen (incompatible interaction)" EXACT [] is_a: GO:0045087 ! innate immune response is_a: GO:0051707 ! response to other organism [Term] id: GO:0009815 name: 1-aminocyclopropane-1-carboxylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O(2) = CO(2) + dehydroascorbate + ethylene + 2 H(2)O + hydrogen cyanide. Ethene is also known as ethylene." [EC:1.14.17.4, RHEA:23643] synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" EXACT [EC:1.14.17.4] synonym: "ACC oxidase activity" EXACT [] synonym: "aminocyclopropanecarboxylate oxidase activity" EXACT [EC:1.14.17.4] synonym: "ethene-forming enzyme" BROAD [] synonym: "ethylene-forming enzyme" BROAD [] xref: EC:1.14.17.4 xref: KEGG:R07214 xref: MetaCyc:ETHYL-RXN xref: RHEA:23643 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0009816 name: defense response to bacterium, incompatible interaction namespace: biological_process def: "A response of an organism to a bacterium that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to bacterium, incompatible interaction" EXACT [] synonym: "defence response to pathogenic bacteria, incompatible interaction" EXACT [] synonym: "defence response to pathogenic bacterium, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic bacteria" EXACT [] synonym: "resistance response to pathogenic bacterium" EXACT [] synonym: "response to pathogenic bacteria (incompatible interaction)" EXACT [] synonym: "response to pathogenic bacterium (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0009817 name: defense response to fungus, incompatible interaction namespace: biological_process def: "A response of an organism to a fungus that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to fungus, incompatible interaction" EXACT [] synonym: "defence response to pathogenic fungi, incompatible interaction" EXACT [] synonym: "defence response to pathogenic fungus, incompatible interaction" EXACT [] synonym: "defense response to fungi, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic fungi" EXACT [] synonym: "resistance response to pathogenic fungus" EXACT [] synonym: "response to pathogenic fungi (incompatible interaction)" EXACT [] synonym: "response to pathogenic fungus (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0050832 ! defense response to fungus [Term] id: GO:0009818 name: defense response to protozoan, incompatible interaction namespace: biological_process def: "A response of an organism to a protozoan that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to pathogenic protozoa, incompatible interaction" EXACT [] synonym: "defence response to pathogenic protozoan, incompatible interaction" EXACT [] synonym: "defence response to protozoan, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic protozoa" EXACT [] synonym: "resistance response to pathogenic protozoan" EXACT [] synonym: "response to pathogenic protozoa (incompatible interaction)" EXACT [] synonym: "response to pathogenic protozoan (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0042832 ! defense response to protozoan [Term] id: GO:0009819 name: drought recovery namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition." [GOC:lr] synonym: "drought tolerance" RELATED [] is_a: GO:0009414 ! response to water deprivation [Term] id: GO:0009820 name: alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] subset: gosubset_prok synonym: "alkaloid metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0009821 name: alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [EC:1.1.1.51, GOC:lr, ISBN:0122146743] subset: gosubset_prok synonym: "alkaloid anabolism" EXACT [] synonym: "alkaloid biosynthesis" EXACT [] synonym: "alkaloid formation" EXACT [] synonym: "alkaloid synthesis" EXACT [] xref: UM-BBD_enzymeID:e0711 is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0009822 name: alkaloid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:01221146743] subset: gosubset_prok synonym: "alkaloid breakdown" EXACT [] synonym: "alkaloid catabolism" EXACT [] synonym: "alkaloid degradation" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0009823 name: cytokinin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators." [GOC:lr] subset: gosubset_prok synonym: "cytokinin breakdown" EXACT [] synonym: "cytokinin catabolism" EXACT [] synonym: "cytokinin degradation" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0009824 name: AMP dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate." [EC:2.5.1.27, RHEA:15288] synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT [] synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [KEGG:R04038] synonym: "adenylate dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "adenylate isopentenyltransferase activity" EXACT [] synonym: "cytokinin synthase activity" RELATED [] synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "isopentenyltransferase activity" BROAD [] xref: EC:2.5.1.27 xref: KEGG:R04038 xref: MetaCyc:RXN-4307 xref: RHEA:15288 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0009825 name: multidimensional cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes." [ISBN:0943088399] subset: gosubset_prok synonym: "cell growth in three dimensions" EXACT [] synonym: "cell growth in two dimensions" NARROW [] is_a: GO:0016049 ! cell growth [Term] id: GO:0009826 name: unidimensional cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399] comment: Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children. subset: gosubset_prok synonym: "cell elongation" NARROW [] synonym: "cell growth along one axis" EXACT [] synonym: "cell growth in one dimension" EXACT [] synonym: "cell morphogenesis by unidimensional growth" EXACT [GOC:dph, GOC:tb] synonym: "polar cell growth" EXACT [] synonym: "polarized cell growth" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0016049 ! cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis [Term] id: GO:0009827 name: plant-type cell wall modification namespace: biological_process def: "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing cell wall modification" EXACT [] is_a: GO:0009664 ! plant-type cell wall organization is_a: GO:0042545 ! cell wall modification [Term] id: GO:0009828 name: plant-type cell wall loosening namespace: biological_process def: "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing cell wall loosening" EXACT [] is_a: GO:0009827 ! plant-type cell wall modification [Term] id: GO:0009829 name: cell wall modification involved in ripening namespace: biological_process def: "The series of events resulting in chemical or structural alterations of existing cell walls that contribute to ripening." [GOC:lr] synonym: "cell wall modification during ripening" RELATED [GOC:dph, GOC:tb] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0009835 ! ripening [Term] id: GO:0009830 name: cell wall modification involved in abscission namespace: biological_process def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission." [GOC:dph, GOC:lr, GOC:sdb_2009, GOC:tb] synonym: "cell wall modification during abscission" RELATED [GOC:dph, GOC:tb] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0060871 ! cellular cell wall disassembly relationship: part_of GO:0009838 ! abscission [Term] id: GO:0009831 name: plant-type cell wall modification involved in multidimensional cell growth namespace: biological_process def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cell wall modification during cell expansion" BROAD [] synonym: "cellulose and pectin-containing cell wall modification during multidimensional cell growth" RELATED [] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0042547 ! cell wall modification involved in multidimensional cell growth [Term] id: GO:0009832 name: plant-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana." [GOC:go_curators, GOC:lr, GOC:mtg_sensu] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] synonym: "cellulose and pectin-containing cell wall biogenesis" EXACT [] is_a: GO:0042546 ! cell wall biogenesis is_a: GO:0071669 ! plant-type cell wall organization or biogenesis [Term] id: GO:0009833 name: primary cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing primary cell wall biogenesis" EXACT [] synonym: "plant-type primary cell wall biogenesis" EXACT [] synonym: "primary cell wall anabolism" BROAD [] synonym: "primary cell wall biosynthetic process" BROAD [] synonym: "primary cell wall formation" BROAD [] synonym: "primary cell wall synthesis" BROAD [] is_a: GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0009834 name: secondary cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing secondary cell wall biogenesis" EXACT [] synonym: "plant-type secondary cell wall biogenesis" EXACT [] synonym: "secondary cell wall anabolism" BROAD [] synonym: "secondary cell wall biosynthetic process" BROAD [] synonym: "secondary cell wall formation" BROAD [] synonym: "secondary cell wall synthesis" BROAD [] is_a: GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0009835 name: ripening namespace: biological_process def: "The series of events causing changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) to make it more attractive to animals and/or aid in seed dispersal." [GOC:lr] subset: goslim_plant xref: Wikipedia:Ripening is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0007275 ! multicellular organismal development relationship: part_of GO:0010154 ! fruit development [Term] id: GO:0009836 name: ripening, climacteric namespace: biological_process def: "A ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset." [GOC:lr, ISBN:0521587840] is_a: GO:0009835 ! ripening [Term] id: GO:0009837 name: ripening, non-climacteric namespace: biological_process def: "A ripening process that does not involve a respiratory burst." [GOC:lr, ISBN:0521587840] is_a: GO:0009835 ! ripening [Term] id: GO:0009838 name: abscission namespace: biological_process def: "The controlled shedding of a body part." [ISBN:0140514031] subset: goslim_plant xref: Wikipedia:Abscission is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0009839 name: SCF complex substrate recognition subunit namespace: cellular_component def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0019005 [Term] id: GO:0009840 name: chloroplastic endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah] is_a: GO:0009368 ! endopeptidase Clp complex is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009841 name: mitochondrial endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah] is_a: GO:0009368 ! endopeptidase Clp complex is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0009842 name: cyanelle namespace: cellular_component def: "A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a peptidoglycan layer as well as a double membrane. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid." [ISBN:052131687, ISBN:1402001894] subset: gosubset_prok synonym: "cyanoplast" EXACT [ISBN:1402001894] synonym: "muroplast" EXACT [ISBN:1402001894] is_a: GO:0009536 ! plastid [Term] id: GO:0009843 name: cyanelle thylakoid namespace: cellular_component def: "A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria." [GOC:lr, GOC:mah, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0031976 ! plastid thylakoid relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0009844 name: germination namespace: biological_process alt_id: GO:0009565 def: "OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." [GOC:lr] comment: This term was made obsolete because it is a grouping term without biological significance. is_obsolete: true [Term] id: GO:0009845 name: seed germination namespace: biological_process def: "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis." [PMID:8281041] xref: Wikipedia:Germination#Seed_germination is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0090351 ! seedling development [Term] id: GO:0009846 name: pollen germination namespace: biological_process def: "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture." [GOC:lr, http://www.bio.uu.nl, ISBN:0943088399] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0009856 ! pollination [Term] id: GO:0009847 name: spore germination namespace: biological_process def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr] subset: gosubset_prok is_a: GO:0032502 ! developmental process [Term] id: GO:0009848 name: indoleacetic acid biosynthetic process via tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan." [GOC:lm, GOC:lr, PMID:10375566] subset: gosubset_prok synonym: "IAA biosynthetic process via tryptophan" EXACT [] synonym: "indoleacetic acid anabolism via tryptophan" EXACT [] synonym: "indoleacetic acid formation via tryptophan" EXACT [] synonym: "indoleacetic acid synthesis via tryptophan" EXACT [] xref: MetaCyc:PWY-581 is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009684 ! indoleacetic acid biosynthetic process [Term] id: GO:0009849 name: tryptophan-independent indoleacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan." [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566] subset: gosubset_prok synonym: "indoleacetic acid biosynthesis, tryptophan-independent" EXACT [] synonym: "indoleacetic acid biosynthetic process, tryptophan-independent" EXACT [] synonym: "tryptophan-independent IAA biosynthetic process" EXACT [] synonym: "tryptophan-independent indoleacetic acid anabolism" EXACT [] synonym: "tryptophan-independent indoleacetic acid biosynthesis" EXACT [] synonym: "tryptophan-independent indoleacetic acid formation" EXACT [] synonym: "tryptophan-independent indoleacetic acid synthesis" EXACT [] xref: MetaCyc:PWY-581 is_a: GO:0009684 ! indoleacetic acid biosynthetic process [Term] id: GO:0009850 name: auxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lr] subset: gosubset_prok synonym: "auxin metabolism" EXACT [] is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0009851 name: auxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0122146743] subset: gosubset_prok synonym: "auxin anabolism" EXACT [] synonym: "auxin biosynthesis" EXACT [] synonym: "auxin formation" EXACT [] synonym: "auxin synthesis" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009852 name: auxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0198547684] subset: gosubset_prok synonym: "auxin breakdown" EXACT [] synonym: "auxin catabolism" EXACT [] synonym: "auxin degradation" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0009853 name: photorespiration namespace: biological_process def: "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: MetaCyc:PWY-181 xref: Wikipedia:Photorespiration is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0009854 name: oxidative photosynthetic carbon pathway namespace: biological_process def: "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2)." [ISBN:00943088399] subset: gosubset_prok is_a: GO:0043094 ! cellular metabolic compound salvage relationship: part_of GO:0009853 ! photorespiration [Term] id: GO:0009855 name: determination of bilateral symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators] synonym: "determination of bilateral asymmetry" EXACT [GOC:dph] is_a: GO:0009799 ! specification of symmetry [Term] id: GO:0009856 name: pollination namespace: biological_process def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the stigma and continuing up to, but not including, fertilization, as defined by sperm-central cell fusion." [GOC:tb, PMID:10973091] subset: goslim_plant xref: Wikipedia:Pollination is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0009858 name: compatible pollen-pistil interaction namespace: biological_process def: "OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style." [GOC:lr, ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. is_obsolete: true [Term] id: GO:0009859 name: pollen hydration namespace: biological_process def: "The process in which water is taken up by pollen." [GOC:lr] is_a: GO:0006833 ! water transport relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0009860 name: pollen tube growth namespace: biological_process def: "Growth of pollen via tip extension of the intine wall." [ISBN:00943088399] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009932 ! cell tip growth is_a: GO:0048588 ! developmental cell growth is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0009861 name: jasmonic acid and ethylene-dependent systemic resistance namespace: biological_process def: "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:jy, PMID:10234273] synonym: "jasmonic acid and ethene-dependent systemic resistance" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance" EXACT [] is_a: GO:0009611 ! response to wounding is_a: GO:0009814 ! defense response, incompatible interaction [Term] id: GO:0009862 name: systemic acquired resistance, salicylic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance." [GOC:jy] synonym: "salicylic acid mediated signaling pathway (systemic acquired resistance)" EXACT [] synonym: "systemic acquired resistance, salicylic acid mediated signalling pathway" EXACT [] is_a: GO:0009863 ! salicylic acid mediated signaling pathway relationship: part_of GO:0009627 ! systemic acquired resistance [Term] id: GO:0009863 name: salicylic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by salicylic acid." [GOC:jy] synonym: "salicylic acid mediated signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071446 ! cellular response to salicylic acid stimulus [Term] id: GO:0009864 name: induced systemic resistance, jasmonic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance." [GOC:jy] synonym: "induced systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] synonym: "jasmonic acid mediated signaling pathway (induced systemic resistance)" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002252 ! immune effector process is_a: GO:0009867 ! jasmonic acid mediated signaling pathway relationship: part_of GO:0009682 ! induced systemic resistance [Term] id: GO:0009865 name: pollen tube adhesion namespace: biological_process def: "The process in which the pollen tube adheres to cells of the stigma and style." [GOC:tair_curators, PMID:12602877] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0009875 ! pollen-pistil interaction relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0009866 name: induced systemic resistance, ethylene mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance." [GOC:jy] synonym: "ethene mediated signaling pathway (induced systemic resistance)" EXACT [] synonym: "ethylene mediated signaling pathway (induced systemic resistance)" EXACT [] synonym: "induced systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "induced systemic resistance, ethene mediated signalling pathway" EXACT [] synonym: "induced systemic resistance, ethylene mediated signalling pathway" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002252 ! immune effector process is_a: GO:0009873 ! ethylene mediated signaling pathway relationship: part_of GO:0009682 ! induced systemic resistance [Term] id: GO:0009867 name: jasmonic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by jasmonic acid." [GOC:jy] synonym: "jasmonic acid mediated signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071395 ! cellular response to jasmonic acid stimulus [Term] id: GO:0009868 name: jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance." [GOC:jy] synonym: "jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] is_a: GO:0009867 ! jasmonic acid mediated signaling pathway is_a: GO:0032260 ! response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0009869 name: incompatible pollen-pistil interaction namespace: biological_process def: "OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth." [PMID:10375566] comment: This term was made obsolete because it represents a phenotype. is_obsolete: true [Term] id: GO:0009870 name: defense response signaling pathway, resistance gene-dependent namespace: biological_process def: "A series of molecular signals that depends upon R-genes and is activated during defense response." [GOC:jy, GOC:mah, PMID:11418339] synonym: "defence response signaling pathway, resistance gene-dependent" EXACT [] synonym: "defence response signalling pathway, resistance gene-dependent" EXACT [] synonym: "defense response signalling pathway, resistance gene-dependent" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0007165 ! signal transduction [Term] id: GO:0009871 name: jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance." [GOC:jy] synonym: "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] synonym: "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway" EXACT [] is_a: GO:0009873 ! ethylene mediated signaling pathway relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0009872 name: gametophytic self-incompatibility namespace: biological_process def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. is_obsolete: true [Term] id: GO:0009873 name: ethylene mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by ethylene (ethene)." [GOC:jy] synonym: "ethene mediated signaling pathway" EXACT [] synonym: "ethene mediated signalling pathway" EXACT [] synonym: "ethylene mediated signalling pathway" EXACT [] is_a: GO:0000160 ! two-component signal transduction system (phosphorelay) is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0071369 ! cellular response to ethylene stimulus [Term] id: GO:0009874 name: sporophytic self-incompatibility namespace: biological_process def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. is_obsolete: true [Term] id: GO:0009875 name: pollen-pistil interaction namespace: biological_process def: "The interaction between a pollen grain and pistil." [GOC:go_curators] subset: goslim_plant is_a: GO:0007154 ! cell communication is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0009856 ! pollination [Term] id: GO:0009876 name: pollen adhesion namespace: biological_process def: "The process in which pollen deposited on the stigma adheres to cells of the stigma." [GOC:tair_curators] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0009877 name: nodulation namespace: biological_process def: "The formation of nitrogen-fixing root nodules on plant roots." [SP_KW:KW-0536] synonym: "nodule development" EXACT [GOC:jl] synonym: "nodule formation" EXACT [GOC:jl] is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0009878 name: nodule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nodule are generated and organized." [GOC:jid] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0009877 ! nodulation [Term] id: GO:0009879 name: determination of radial symmetry namespace: biological_process def: "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis." [GOC:go_curators] synonym: "determination of radial asymmetry" EXACT [GOC:dph] is_a: GO:0009799 ! specification of symmetry relationship: part_of GO:0009956 ! radial pattern formation [Term] id: GO:0009880 name: embryonic pattern specification namespace: biological_process def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] synonym: "embryonic pattern biosynthesis" BROAD [] synonym: "embryonic pattern formation" BROAD [] synonym: "ventral/lateral system" RELATED [] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0009881 name: photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] subset: gosubset_prok synonym: "blue-sensitive opsin" NARROW [] synonym: "green-sensitive opsin" NARROW [] synonym: "long-wave-sensitive opsin" NARROW [] synonym: "opsin" NARROW [] synonym: "red-sensitive opsin" NARROW [] synonym: "short-wave-sensitive opsin" NARROW [] synonym: "UV-sensitive opsin" NARROW [] synonym: "violet-sensitive opsin" NARROW [] is_a: GO:0004872 ! receptor activity [Term] id: GO:0009882 name: blue light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb] subset: gosubset_prok is_a: GO:0009881 ! photoreceptor activity [Term] id: GO:0009883 name: red or far-red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr] synonym: "red/far-red light photoreceptor activity" EXACT [] is_a: GO:0009881 ! photoreceptor activity [Term] id: GO:0009884 name: cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin to initiate a change in cell activity." [GOC:lr] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0009885 name: transmembrane histidine kinase cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah] is_a: GO:0009784 ! transmembrane receptor histidine kinase activity is_a: GO:0009884 ! cytokinin receptor activity [Term] id: GO:0009886 name: post-embryonic morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which anatomical structures are generated and organized." [GOC:go_curators] synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009791 ! post-embryonic development [Term] id: GO:0009887 name: organ morphogenesis namespace: biological_process def: "Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "histogenesis and organogenesis" BROAD [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048513 ! organ development [Term] id: GO:0009888 name: tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] synonym: "histogenesis" EXACT [] synonym: "histogenesis and organogenesis" BROAD [] xref: Wikipedia:Histogenesis is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process relationship: negatively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gosubset_prok synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process relationship: positively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gosubset_prok synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "stimulation of metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0009056 ! catabolic process [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process relationship: negatively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gosubset_prok synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process relationship: positively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009897 name: external side of plasma membrane namespace: cellular_component def: "The side of the plasma membrane that is opposite to the side that faces the cytoplasm." [GOC:tb] subset: gosubset_prok synonym: "juxtamembrane" BROAD [] synonym: "outer surface of cytoplasmic membrane" EXACT [] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0009898 name: internal side of plasma membrane namespace: cellular_component def: "The side of the plasma membrane that faces the cytoplasm." [GOC:tb] subset: gosubset_prok synonym: "juxtamembrane" BROAD [] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0009899 name: ent-kaurene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate." [EC:4.2.3.19, RHEA:22223] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.19] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" EXACT [EC:4.2.3.19] synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19] synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19] xref: EC:4.2.3.19 xref: KEGG:R05092 xref: MetaCyc:4.2.3.19-RXN xref: RHEA:22223 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0009900 name: dehiscence namespace: biological_process def: "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it." [ISBN:0879015322] xref: Wikipedia:Dehiscence_(botany) is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0009901 name: anther dehiscence namespace: biological_process def: "The dehiscence of an anther to release the pollen grains contained within it." [GOC:tb] is_a: GO:0009900 ! dehiscence relationship: part_of GO:0048653 ! anther development [Term] id: GO:0009902 name: chloroplast relocation namespace: biological_process def: "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623] synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957] is_a: GO:0009658 ! chloroplast organization is_a: GO:0051667 ! establishment of plastid localization [Term] id: GO:0009903 name: chloroplast avoidance movement namespace: biological_process def: "The relocation process in which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery." [GOC:tb, PMID:11978863] synonym: "high-fluence-rate response" RELATED [] is_a: GO:0009902 ! chloroplast relocation [Term] id: GO:0009904 name: chloroplast accumulation movement namespace: biological_process def: "The relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis." [GOC:tb, PMID:11978863] synonym: "low-fluence-rate response" RELATED [] is_a: GO:0009902 ! chloroplast relocation [Term] id: GO:0009905 name: ent-copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, RHEA:14844] synonym: "diterpene cyclase activity" BROAD [] synonym: "ent-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.13] synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13] synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13] xref: EC:5.5.1.13 xref: KEGG:R02068 xref: MetaCyc:5.5.1.13-RXN xref: RHEA:14844 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0009906 name: response to photoperiod, blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009637 ! response to blue light is_a: GO:0009648 ! photoperiodism [Term] id: GO:0009907 name: response to photoperiod, red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009648 ! photoperiodism is_a: GO:0010114 ! response to red light [Term] id: GO:0009908 name: flower development namespace: biological_process alt_id: GO:0048409 def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GOC:tb, ISBN:0879015322] subset: goslim_plant is_a: GO:0009791 ! post-embryonic development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0009909 name: regulation of flower development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flower development." [GOC:go_curators] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0009908 ! flower development [Term] id: GO:0009910 name: negative regulation of flower development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of flower development." [GOC:go_curators] synonym: "down regulation of flower development" EXACT [] synonym: "down-regulation of flower development" EXACT [] synonym: "downregulation of flower development" EXACT [] synonym: "inhibition of flower development" NARROW [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0009908 ! flower development [Term] id: GO:0009911 name: positive regulation of flower development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flower development." [GOC:go_curators] synonym: "activation of flower development" NARROW [] synonym: "stimulation of flower development" NARROW [] synonym: "up regulation of flower development" EXACT [] synonym: "up-regulation of flower development" EXACT [] synonym: "upregulation of flower development" EXACT [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0009908 ! flower development [Term] id: GO:0009912 name: auditory receptor cell fate commitment namespace: biological_process def: "The process in which the cellular identity of auditory hair cells is acquired and determined." [GOC:lr] synonym: "auditory hair cell fate commitment" EXACT [] is_a: GO:0060120 ! inner ear receptor cell fate commitment relationship: part_of GO:0042491 ! auditory receptor cell differentiation [Term] id: GO:0009913 name: epidermal cell differentiation namespace: biological_process alt_id: GO:0043355 def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0008544 ! epidermis development [Term] id: GO:0009914 name: hormone transport namespace: biological_process def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb] subset: goslim_pir is_a: GO:0006810 ! transport is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0009915 name: phloem sucrose loading namespace: biological_process def: "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:sm] synonym: "phloem loading" BROAD [] is_a: GO:0010233 ! phloem transport is_a: GO:0015770 ! sucrose transport [Term] id: GO:0009916 name: alternative oxidase activity namespace: molecular_function def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399] is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0009917 name: sterol 5-alpha reductase activity namespace: molecular_function def: "Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0009918 name: sterol delta7 reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399] synonym: "sterol delta-7 reductase activity" EXACT [] xref: MetaCyc:RXN-707 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0009919 name: cytokinesis (sensu Viridiplantae) namespace: biological_process def: "OBSOLETE. The division of a cell into two daughter cells with cell walls." [GOC:tb] comment: This term was made obsolete because its meaning was changed significantly. is_obsolete: true consider: GO:0000911 [Term] id: GO:0009920 name: cell plate formation involved in plant-type cell wall biogenesis namespace: biological_process def: "The cell cycle process in which the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322] synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT [] is_a: GO:0000919 ! cell plate assembly is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007067 ! mitosis relationship: part_of GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0009921 name: auxin efflux carrier complex namespace: cellular_component def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0009922 name: fatty acid elongase activity namespace: molecular_function def: "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN xref: Reactome:6067 "fatty acid elongase activity" is_a: GO:0004312 ! fatty acid synthase activity [Term] id: GO:0009923 name: fatty acid elongase complex namespace: cellular_component def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0009924 name: octadecanal decarbonylase activity namespace: molecular_function def: "Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb] synonym: "octadecanal alkane-lyase activity" EXACT [] xref: EC:4.1.99.5 xref: MetaCyc:OCTADECANAL-DECARBONYLASE-RXN is_a: GO:0071771 ! aldehyde decarbonylase activity [Term] id: GO:0009925 name: basal plasma membrane namespace: cellular_component def: "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0016323 ! basolateral plasma membrane relationship: part_of GO:0045178 ! basal part of cell [Term] id: GO:0009926 name: auxin polar transport namespace: biological_process def: "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally." [GOC:sm] is_a: GO:0060918 ! auxin transport [Term] id: GO:0009927 name: histidine phosphotransfer kinase activity namespace: molecular_function def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140] subset: gosubset_prok is_a: GO:0004871 ! signal transducer activity is_a: GO:0016301 ! kinase activity [Term] id: GO:0009930 name: longitudinal side of cell surface namespace: cellular_component def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm] is_a: GO:0044464 ! cell part relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0009931 name: calcium-dependent protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions." [GOC:mah] is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0010857 ! calcium-dependent protein kinase activity [Term] id: GO:0009932 name: cell tip growth namespace: biological_process def: "Growth that occurs specifically at the tip of a cell." [GOC:jid] is_a: GO:0009826 ! unidimensional cell growth [Term] id: GO:0009933 name: meristem structural organization namespace: biological_process def: "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm, ISBN:0198547684] synonym: "meristem organisation" BROAD [] synonym: "meristem organization" BROAD [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0009934 name: regulation of meristem structural organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meristem organization." [GOC:jid] synonym: "regulation of meristem organisation" EXACT [] synonym: "regulation of meristem organization" BROAD [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0048509 ! regulation of meristem development relationship: regulates GO:0009933 ! meristem structural organization [Term] id: GO:0009935 name: nutrient import namespace: biological_process def: "OBSOLETE. The directed movement of nutrients into a cell or organelle." [GOC:sm] comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. subset: gosubset_prok synonym: "nutrient uptake" EXACT [] is_obsolete: true consider: GO:0006810 [Term] id: GO:0009936 name: expansin namespace: molecular_function def: "OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0009505 replaced_by: GO:0016049 [Term] id: GO:0009937 name: regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling." [GOC:go_curators] synonym: "regulation of gibberellic acid mediated signalling" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009938 name: negative regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] synonym: "down regulation of gibberellic acid mediated signaling" EXACT [] synonym: "down-regulation of gibberellic acid mediated signaling" EXACT [] synonym: "downregulation of gibberellic acid mediated signaling" EXACT [] synonym: "inhibition of gibberellic acid mediated signaling" NARROW [] synonym: "negative regulation of gibberellic acid mediated signalling" EXACT [] is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009939 name: positive regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] synonym: "activation of gibberellic acid mediated signaling" NARROW [] synonym: "positive regulation of gibberellic acid mediated signalling" EXACT [] synonym: "stimulation of gibberellic acid mediated signaling" NARROW [] synonym: "up regulation of gibberellic acid mediated signaling" EXACT [] synonym: "up-regulation of gibberellic acid mediated signaling" EXACT [] synonym: "upregulation of gibberellic acid mediated signaling" EXACT [] is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009940 name: amino-terminal vacuolar sorting propeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin coated vesicles." [GOC:sm, PMID:10871276] is_a: GO:0010209 ! vacuolar sorting signal binding [Term] id: GO:0009941 name: chloroplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] is_a: GO:0009526 ! plastid envelope is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009942 name: longitudinal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root." [GOC:tb] synonym: "apical-basal pattern specification" EXACT [] synonym: "longitudinal axis determination" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0009943 name: adaxial/abaxial axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] synonym: "adaxial/abaxial determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009955 ! adaxial/abaxial pattern formation [Term] id: GO:0009944 name: polarity specification of adaxial/abaxial axis namespace: biological_process def: "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009943 ! adaxial/abaxial axis specification [Term] id: GO:0009945 name: radial axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point." [GOC:dph, GOC:go_curators, GOC:isa_complete] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009956 ! radial pattern formation [Term] id: GO:0009946 name: proximal/distal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "proximal/distal axis determination" RELATED [GOC:dph] synonym: "proximodistal axis specification" EXACT [] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0009947 name: centrolateral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf." [GOC:tb, ISBN:0865427429] synonym: "centrolateral axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification [Term] id: GO:0009948 name: anterior/posterior axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "anterior/posterior axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009952 ! anterior/posterior pattern formation [Term] id: GO:0009949 name: polarity specification of anterior/posterior axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009948 ! anterior/posterior axis specification [Term] id: GO:0009950 name: dorsal/ventral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "dorsal/ventral axis determination" RELATED [GOC:dph] synonym: "dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0009951 name: polarity specification of dorsal/ventral axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] synonym: "polarity specification of dorsal-ventral axis" EXACT [GOC:mah] synonym: "polarity specification of dorsoventral axis" EXACT [GOC:mah] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0009952 name: anterior/posterior pattern formation namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "anterior/posterior pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009953 name: dorsal/ventral pattern formation namespace: biological_process def: "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "dorsal/ventral pattern specification" NARROW [] synonym: "dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0003002 ! regionalization [Term] id: GO:0009954 name: proximal/distal pattern formation namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "proximal/distal pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009955 name: adaxial/abaxial pattern formation namespace: biological_process def: "The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "adaxial/abaxial pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009956 name: radial pattern formation namespace: biological_process def: "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "radial pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009957 name: epidermal cell fate specification namespace: biological_process alt_id: GO:0043356 def: "The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu, GOC:sm] synonym: "hypodermal cell fate specification" RELATED [GOC:kmv, GOC:rk] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0009913 ! epidermal cell differentiation [Term] id: GO:0009958 name: positive gravitropism namespace: biological_process def: "The orientation of plant parts towards gravity." [GOC:sm] synonym: "root gravitropism" NARROW [] is_a: GO:0009630 ! gravitropism [Term] id: GO:0009959 name: negative gravitropism namespace: biological_process def: "The orientation of plant parts away from gravity." [GOC:sm] synonym: "shoot gravitropism" NARROW [] is_a: GO:0009630 ! gravitropism [Term] id: GO:0009960 name: endosperm development namespace: biological_process def: "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo." [GOC:sm] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009888 ! tissue development relationship: part_of GO:0048316 ! seed development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0009961 name: response to 1-aminocyclopropane-1-carboxylic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:jl] is_a: GO:0043200 ! response to amino acid stimulus [Term] id: GO:0009962 name: regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] subset: gosubset_prok synonym: "regulation of flavonoid anabolism" EXACT [] synonym: "regulation of flavonoid biosynthesis" EXACT [] synonym: "regulation of flavonoid formation" EXACT [] synonym: "regulation of flavonoid synthesis" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009963 name: positive regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] subset: gosubset_prok synonym: "activation of flavonoid biosynthetic process" NARROW [] synonym: "positive regulation of flavonoid anabolism" EXACT [] synonym: "positive regulation of flavonoid biosynthesis" EXACT [] synonym: "positive regulation of flavonoid formation" EXACT [] synonym: "positive regulation of flavonoid synthesis" EXACT [] synonym: "stimulation of flavonoid biosynthetic process" NARROW [] synonym: "up regulation of flavonoid biosynthetic process" EXACT [] synonym: "up-regulation of flavonoid biosynthetic process" EXACT [] synonym: "upregulation of flavonoid biosynthetic process" EXACT [] is_a: GO:0009962 ! regulation of flavonoid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process relationship: positively_regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009964 name: negative regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] subset: gosubset_prok synonym: "down regulation of flavonoid biosynthetic process" EXACT [] synonym: "down-regulation of flavonoid biosynthetic process" EXACT [] synonym: "downregulation of flavonoid biosynthetic process" EXACT [] synonym: "inhibition of flavonoid biosynthetic process" NARROW [] synonym: "negative regulation of flavonoid anabolism" EXACT [] synonym: "negative regulation of flavonoid biosynthesis" EXACT [] synonym: "negative regulation of flavonoid formation" EXACT [] synonym: "negative regulation of flavonoid synthesis" EXACT [] is_a: GO:0009962 ! regulation of flavonoid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process relationship: negatively_regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009965 name: leaf morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the leaf are generated and organized." [GOC:go_curators] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0010016 ! shoot morphogenesis relationship: part_of GO:0048366 ! leaf development [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process alt_id: GO:0035466 def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] subset: gosubset_prok synonym: "regulation of signaling pathway" RELATED [] synonym: "regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007165 ! signal transduction [Term] id: GO:0009967 name: positive regulation of signal transduction namespace: biological_process alt_id: GO:0035468 def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] subset: gosubset_prok synonym: "activation of signal transduction" NARROW [] synonym: "positive regulation of signaling pathway" RELATED [] synonym: "positive regulation of signalling pathway" RELATED [GOC:mah] synonym: "stimulation of signal transduction" NARROW [] synonym: "up regulation of signal transduction" EXACT [] synonym: "up-regulation of signal transduction" EXACT [] synonym: "upregulation of signal transduction" EXACT [] xref: Reactome:110518 "Activated DTOR also phosphorylates D4EBP" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009968 name: negative regulation of signal transduction namespace: biological_process alt_id: GO:0035467 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] subset: gosubset_prok synonym: "down regulation of signal transduction" EXACT [] synonym: "down-regulation of signal transduction" EXACT [] synonym: "downregulation of signal transduction" EXACT [] synonym: "inhibition of signal transduction" NARROW [] synonym: "negative regulation of signaling pathway" RELATED [] synonym: "negative regulation of signalling pathway" RELATED [GOC:mah] xref: Reactome:110485 "DTSC1 AND DTSC2 form a complex" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009969 name: xyloglucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of 1->4-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-1->6 residues, which is present in the primary cell wall of most higher plants." [GOC:sm] subset: gosubset_prok synonym: "xyloglucan anabolism" EXACT [] synonym: "xyloglucan biosynthesis" EXACT [] synonym: "xyloglucan formation" EXACT [] synonym: "xyloglucan synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process [Term] id: GO:0009970 name: cellular response to sulfate starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate." [GOC:sm] synonym: "cellular response to sulphate starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0009971 name: anastral spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272] is_a: GO:0007053 ! spindle assembly involved in male meiosis is_a: GO:0055048 ! anastral spindle assembly [Term] id: GO:0009972 name: cytidine deamination namespace: biological_process def: "The removal of amino group in the presence of water." [GOC:sm] subset: gosubset_prok is_a: GO:0006216 ! cytidine catabolic process [Term] id: GO:0009973 name: adenylyl-sulfate reductase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor." [EC:1.8.99.2, PMID:5421934] subset: gosubset_prok synonym: "adenosine 5'-phosphosulfate reductase" EXACT [EC:1.8.99.2] synonym: "adenosine phosphosulfate reductase activity" EXACT [EC:1.8.99.2] synonym: "adenylyl-sulphate reductase activity" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "APS reductase activity" EXACT [EC:1.8.99.2] synonym: "APS-reductase" EXACT [EC:1.8.99.2] xref: EC:1.8.99.2 xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0009974 name: zeinoxanthin epsilon hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [MetaCyc:RXN-5962, PMID:8837513] xref: EC:1.14.99.- xref: MetaCyc:RXN-5962 is_a: GO:0072374 ! carotene epsilon hydroxylase activity [Term] id: GO:0009975 name: cyclase activity namespace: molecular_function def: "Catalysis of a ring closure reaction." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0009976 name: tocopherol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)." [PMID:12213958] is_a: GO:0009975 ! cyclase activity [Term] id: GO:0009977 name: proton motive force dependent protein transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of proteins from one side of the membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245] synonym: "delta-pH-dependent protein transporter activity" EXACT [] synonym: "pH-dependent protein transporter activity" EXACT [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: GO:0009978 name: allene oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] synonym: "HPI" RELATED [EC:4.2.1.92] synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] xref: MetaCyc:RXN1F-19 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0009979 name: 16:0 monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule." [GOC:mah, MetaCyc:RXN-1728, MetaCyc:RXN-8304, MetaCyc:RXN-8307] is_a: GO:0042389 ! omega-3 fatty acid desaturase activity [Term] id: GO:0009980 name: glutamate carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. subset: gosubset_prok synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11] synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11] synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11] synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11] synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11] xref: EC:3.4.17.11 xref: MetaCyc:3.4.17.11-RXN is_obsolete: true replaced_by: GO:0004180 [Term] id: GO:0009982 name: pseudouridine synthase activity namespace: molecular_function alt_id: GO:0016439 def: "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. subset: gosubset_prok synonym: "transfer ribonucleate pseudouridine synthetase activity" NARROW [EC:5.4.99.12] synonym: "transfer RNA pseudouridine synthetase activity" NARROW [EC:5.4.99.12] synonym: "tRNA pseudouridylate synthase I activity" NARROW [EC:5.4.99.12] synonym: "tRNA-pseudouridine synthase activity" NARROW [] synonym: "tRNA-pseudouridine synthase I activity" NARROW [] synonym: "tRNA-uridine isomerase activity" NARROW [EC:5.4.99.12] synonym: "tRNA-uridine uracilmutase activity" NARROW [EC:5.4.99.12] xref: EC:5.4.99.12 xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0009983 name: tyrosine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0009984 name: adenylate forming enzyme activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate." [PMID:12084835] comment: This term was made obsolete because it does not refer to a specific reaction but rather to a process which results in the formation of AMP. is_obsolete: true consider: GO:0046033 [Term] id: GO:0009985 name: dihydroflavonol(thiole) lyase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [] comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. is_obsolete: true [Term] id: GO:0009986 name: cell surface namespace: cellular_component alt_id: GO:0009928 alt_id: GO:0009929 def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall. subset: goslim_pir subset: gosubset_prok synonym: "cell associated" EXACT [] synonym: "cell bound" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0009988 name: cell-cell recognition namespace: biological_process def: "Cell recognition between cells, usually involving the formation of specialized cell junctions." [ISBN:0824072820] is_a: GO:0008037 ! cell recognition [Term] id: GO:0009989 name: cell-matrix recognition namespace: biological_process def: "Cell recognition that involves the interaction of the cell with the extracellular matrix." [ISBN:0824072820] is_a: GO:0008037 ! cell recognition [Term] id: GO:0009990 name: contact guidance namespace: biological_process def: "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells." [ISBN:0824072820] is_a: GO:0009989 ! cell-matrix recognition [Term] id: GO:0009991 name: response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators] subset: goslim_plant subset: gosubset_prok is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0009992 name: cellular water homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of water within a cell." [GOC:dph, GOC:tb] synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb] is_a: GO:0006884 ! cell volume homeostasis is_a: GO:0030104 ! water homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0009994 name: oocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] synonym: "oocyte cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0009995 name: soluble molecule recognition namespace: biological_process def: "The recognition of soluble molecules in the environment." [GOC:go_curators] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0009996 name: negative regulation of cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators] synonym: "down regulation of cell fate specification" EXACT [] synonym: "down-regulation of cell fate specification" EXACT [] synonym: "downregulation of cell fate specification" EXACT [] synonym: "inhibition of cell fate specification" NARROW [] synonym: "suppression of cell fate" EXACT [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0042659 ! regulation of cell fate specification relationship: negatively_regulates GO:0001708 ! cell fate specification [Term] id: GO:0009997 name: negative regulation of cardioblast cell fate specification namespace: biological_process alt_id: GO:0042687 def: "Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "down regulation of cardioblast cell fate specification" EXACT [] synonym: "down-regulation of cardioblast cell fate specification" EXACT [] synonym: "downregulation of cardioblast cell fate specification" EXACT [] synonym: "inhibition of cardioblast cell fate specification" NARROW [] synonym: "suppression of cardioblast cell fate" EXACT [] is_a: GO:0042686 ! regulation of cardioblast cell fate specification is_a: GO:2000044 ! negative regulation of cardiac cell fate specification relationship: negatively_regulates GO:0042685 ! cardioblast cell fate specification [Term] id: GO:0009998 name: negative regulation of retinal cone cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell." [GOC:go_curators] synonym: "down regulation of retinal cone cell fate specification" EXACT [] synonym: "down-regulation of retinal cone cell fate specification" EXACT [] synonym: "downregulation of retinal cone cell fate specification" EXACT [] synonym: "inhibition of retinal cone cell fate specification" NARROW [] synonym: "negative regulation of retina cone cell fate specification" EXACT [] synonym: "suppression of retina cone cell fate" EXACT [] synonym: "suppression of retinal cone cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042673 ! regulation of retinal cone cell fate specification relationship: negatively_regulates GO:0042672 ! retinal cone cell fate specification [Term] id: GO:0009999 name: negative regulation of auditory receptor cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell." [GOC:go_curators] synonym: "down regulation of auditory receptor cell fate specification" EXACT [] synonym: "down-regulation of auditory receptor cell fate specification" EXACT [] synonym: "downregulation of auditory receptor cell fate specification" EXACT [] synonym: "inhibition of auditory receptor cell fate specification" NARROW [] synonym: "negative regulation of auditory hair cell fate specification" EXACT [] synonym: "suppression of auditory receptor cell fate" EXACT [] synonym: "suppression of hair cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042669 ! regulation of auditory receptor cell fate specification relationship: negatively_regulates GO:0042667 ! auditory receptor cell fate specification [Term] id: GO:0010001 name: glial cell differentiation namespace: biological_process alt_id: GO:0007404 alt_id: GO:0043360 def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] synonym: "glia cell differentiation" EXACT [] synonym: "neuroglia differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0010002 name: cardioblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart] synonym: "cardioblast cell differentiation" EXACT [] synonym: "cardiomyocyte generation" RELATED [] is_a: GO:0035051 ! cardiac cell differentiation [Term] id: GO:0010004 name: gastrulation involving germ band extension namespace: biological_process def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001703 ! gastrulation with mouth forming first [Term] id: GO:0010005 name: cortical microtubule, transverse to long axis namespace: cellular_component def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399] is_a: GO:0055028 ! cortical microtubule [Term] id: GO:0010006 name: Toc complex namespace: cellular_component def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0010007 name: magnesium chelatase complex namespace: cellular_component def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180] is_a: GO:0043234 ! protein complex is_a: GO:0044434 ! chloroplast part [Term] id: GO:0010008 name: endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an endosome." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044440 ! endosomal part [Term] id: GO:0010009 name: external side of endosome membrane namespace: cellular_component def: "The external (cytoplasmic face) of an endosome membrane." [GOC:lr] is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0010011 name: auxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with auxin, plant hormones that regulate aspects of plant growth." [GOC:sm] synonym: "auxin receptor" NARROW [] is_a: GO:0042562 ! hormone binding [Term] id: GO:0010012 name: steroid 22-alpha hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb] is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0010013 name: N-1-naphthylphthalamic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm] is_a: GO:0008144 ! drug binding [Term] id: GO:0010014 name: meristem initiation namespace: biological_process def: "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009933 ! meristem structural organization [Term] id: GO:0010015 name: root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support." [GOC:sm, ISBN:0877797099] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048364 ! root development [Term] id: GO:0010016 name: shoot morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground." [GOC:sm, ISBN:0877797099] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048367 ! shoot development [Term] id: GO:0010017 name: red or far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "phytochrome signaling pathway" BROAD [] synonym: "red or far red light signalling pathway" EXACT [] synonym: "red or far-red light signaling pathway" EXACT [GOC:tb] synonym: "red/far red light signaling pathway" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071489 ! cellular response to red or far red light [Term] id: GO:0010018 name: far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "far red light signalling pathway" EXACT [] synonym: "far red signaling pathway" EXACT [GOC:tb] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071490 ! cellular response to far red light [Term] id: GO:0010019 name: chloroplast-nucleus signaling pathway namespace: biological_process def: "The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." [PMID:8972595] synonym: "chloroplast-nucleus signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0010020 name: chloroplast fission namespace: biological_process def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr] synonym: "chloroplast division" EXACT [] is_a: GO:0009658 ! chloroplast organization is_a: GO:0043572 ! plastid fission [Term] id: GO:0010021 name: amylopectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amylopectin, the (1,4) linked alpha glucose units with alpha-(1,6) linkages." [ISBN:0943088399] subset: gosubset_prok synonym: "amylopectin anabolism" EXACT [] synonym: "amylopectin biosynthesis" EXACT [] synonym: "amylopectin formation" EXACT [] synonym: "amylopectin synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process relationship: part_of GO:0019252 ! starch biosynthetic process [Term] id: GO:0010022 name: meristem determinacy namespace: biological_process def: "The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [GOC:lr] is_a: GO:0032502 ! developmental process relationship: part_of GO:0010073 ! meristem maintenance [Term] id: GO:0010023 name: proanthocyanidin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proanthocyanidin." [GOC:lm] subset: gosubset_prok synonym: "proanthocyanidin anabolism" EXACT [] synonym: "proanthocyanidin biosynthesis" EXACT [] synonym: "proanthocyanidin formation" EXACT [] synonym: "proanthocyanidin synthesis" EXACT [] xref: MetaCyc:PWY-641 is_a: GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0010024 name: phytochromobilin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha." [PMID:11402195] subset: gosubset_prok synonym: "phytochromobilin anabolism" EXACT [] synonym: "phytochromobilin biosynthesis" EXACT [] synonym: "phytochromobilin formation" EXACT [] synonym: "phytochromobilin synthesis" EXACT [] is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0051202 ! phytochromobilin metabolic process [Term] id: GO:0010025 name: wax biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399] subset: gosubset_prok synonym: "wax anabolism" EXACT [] synonym: "wax biosynthesis" EXACT [] synonym: "wax formation" EXACT [] synonym: "wax synthesis" EXACT [] xref: MetaCyc:PWY-282 is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0010166 ! wax metabolic process [Term] id: GO:0010026 name: trichome differentiation namespace: biological_process alt_id: GO:0048271 def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, PMID:9367433] synonym: "trichome cell differentiation" EXACT [] is_a: GO:0009913 ! epidermal cell differentiation [Term] id: GO:0010027 name: thylakoid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:tb] comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'. synonym: "thylakoid membrane organisation" EXACT [GOC:curators] synonym: "thylakoid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0010028 name: xanthophyll cycle namespace: biological_process def: "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II." [ISBN:0122146743] subset: gosubset_prok xref: MetaCyc:PWY-1141 xref: Wikipedia:Xanthophyll#Xanthophyll_cycle is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0010029 name: regulation of seed germination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed germination." [GOC:sm] is_a: GO:0048580 ! regulation of post-embryonic development relationship: regulates GO:0009845 ! seed germination [Term] id: GO:0010030 name: positive regulation of seed germination namespace: biological_process def: "Any process that activates or increase the rate of seed germination." [GOC:sm] synonym: "activation of seed germination" NARROW [] synonym: "stimulation of seed germination" NARROW [] synonym: "up regulation of seed germination" EXACT [] synonym: "up-regulation of seed germination" EXACT [] synonym: "upregulation of seed germination" EXACT [] is_a: GO:0010029 ! regulation of seed germination is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0009845 ! seed germination [Term] id: GO:0010031 name: circumnutation namespace: biological_process def: "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth." [GOC:mtg_MIT_16mar07, ISBN:0192801023] is_a: GO:0050879 ! multicellular organismal movement [Term] id: GO:0010032 name: meiotic chromosome condensation namespace: biological_process def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0030261 ! chromosome condensation is_a: GO:0070192 ! chromosome organization involved in meiosis [Term] id: GO:0010033 name: response to organic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm] subset: gosubset_prok is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0010034 name: response to acetate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm] subset: gosubset_prok is_a: GO:0010033 ! response to organic substance [Term] id: GO:0010035 name: response to inorganic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm] subset: gosubset_prok is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0010036 name: response to boron-containing substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron-containing substance stimulus." [GOC:sm] synonym: "response to boron" EXACT [GOC:curators] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010037 name: response to carbon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010038 name: response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] subset: gosubset_prok synonym: "heavy metal sensitivity/resistance" RELATED [] synonym: "response to heavy metal" NARROW [] synonym: "response to metal" EXACT [] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010039 name: response to iron ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm] synonym: "response to iron" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010040 name: response to iron(II) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:sm] synonym: "response to iron(II)" EXACT [] is_a: GO:0010039 ! response to iron ion [Term] id: GO:0010041 name: response to iron(III) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:sm] synonym: "response to iron(III)" EXACT [] is_a: GO:0010039 ! response to iron ion [Term] id: GO:0010042 name: response to manganese ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm] synonym: "response to manganese" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010043 name: response to zinc ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] synonym: "response to zinc" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010044 name: response to aluminum ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:sm] synonym: "response to aluminium ion" EXACT [] synonym: "response to aluminum" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010045 name: response to nickel ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:sm] synonym: "response to nickel" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010046 name: response to mycotoxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin are a toxic chemical substance produced by fungi." [GOC:sm] is_a: GO:0009636 ! response to toxin [Term] id: GO:0010047 name: fruit dehiscence namespace: biological_process def: "The process leading to the spontaneous opening of the fruit permitting the escape of seeds." [GOC:tb, ISBN:0471245208] is_a: GO:0009900 ! dehiscence [Term] id: GO:0010048 name: vernalization response namespace: biological_process def: "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures." [GOC:tair_curators, ISBN:0521591392] is_a: GO:0009409 ! response to cold [Term] id: GO:0010049 name: acquisition of reproductive competence namespace: biological_process def: "The process in which a plant acquires the ability to respond to a floral inductive signal." [GOC:tair_curators] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0010050 name: vegetative phase change namespace: biological_process def: "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tb] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0010051 name: xylem and phloem pattern formation namespace: biological_process def: "The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "vascular tissue pattern formation" EXACT [] is_a: GO:0003002 ! regionalization [Term] id: GO:0010052 name: guard cell differentiation namespace: biological_process def: "The process in which a guard mother cell acquires the specialized features of a guard cell." [GOC:expert_db, GOC:tb] synonym: "stomatal cell differentiation" RELATED [] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0010103 ! stomatal complex morphogenesis [Term] id: GO:0010053 name: root epidermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast." [GOC:tb] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0010015 ! root morphogenesis [Term] id: GO:0010054 name: trichoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair." [GOC:tb] synonym: "trichoblast cell differentiation" EXACT [] is_a: GO:0010053 ! root epidermal cell differentiation [Term] id: GO:0010055 name: atrichoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair." [GOC:tb] is_a: GO:0010053 ! root epidermal cell differentiation [Term] id: GO:0010056 name: atrichoblast fate specification namespace: biological_process def: "The process involved in the specification of an atrichoblast." [GOC:tb] is_a: GO:0009957 ! epidermal cell fate specification relationship: part_of GO:0010055 ! atrichoblast differentiation [Term] id: GO:0010057 name: trichoblast fate specification namespace: biological_process def: "The process involved in the specification of a trichoblast." [GOC:tb] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0010054 ! trichoblast differentiation [Term] id: GO:0010058 name: regulation of atrichoblast fate specification namespace: biological_process def: "Any process that modulates atrichoblast fate specification." [GOC:tb] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:2000067 ! regulation of root morphogenesis relationship: regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010059 name: positive regulation of atrichoblast fate specification namespace: biological_process def: "Any process that induces or promotes atrichoblast fate specification." [GOC:tb] synonym: "activation of atrichoblast fate" NARROW [] synonym: "stimulation of atrichoblast fate" NARROW [] synonym: "up regulation of atrichoblast fate" EXACT [] synonym: "up-regulation of atrichoblast fate" EXACT [] synonym: "upregulation of atrichoblast fate" EXACT [] is_a: GO:0010058 ! regulation of atrichoblast fate specification is_a: GO:0042660 ! positive regulation of cell fate specification relationship: positively_regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010060 name: negative regulation of atrichoblast fate specification namespace: biological_process def: "Any process that suppresses atrichoblast fate specification." [GOC:tb] synonym: "down regulation of atrichoblast fate" EXACT [] synonym: "down-regulation of atrichoblast fate" EXACT [] synonym: "downregulation of atrichoblast fate" EXACT [] synonym: "inhibition of atrichoblast fate" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0010058 ! regulation of atrichoblast fate specification relationship: negatively_regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010061 name: regulation of trichoblast fate specification namespace: biological_process def: "Any process that modulates trichoblast fate specification." [GOC:tb] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:2000067 ! regulation of root morphogenesis relationship: regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010062 name: negative regulation of trichoblast fate specification namespace: biological_process def: "Any process that suppresses trichoblast fate specification." [GOC:tb] synonym: "down regulation of trichoblast fate" EXACT [] synonym: "down-regulation of trichoblast fate" EXACT [] synonym: "downregulation of trichoblast fate" EXACT [] synonym: "inhibition of trichoblast fate" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0010061 ! regulation of trichoblast fate specification relationship: negatively_regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010063 name: positive regulation of trichoblast fate specification namespace: biological_process def: "Any process that induces or promotes trichoblast fate specification." [GOC:tb] synonym: "activation of trichoblast fate" NARROW [] synonym: "stimulation of trichoblast fate" NARROW [] synonym: "up regulation of trichoblast fate" EXACT [] synonym: "up-regulation of trichoblast fate" EXACT [] synonym: "upregulation of trichoblast fate" EXACT [] is_a: GO:0010061 ! regulation of trichoblast fate specification is_a: GO:0042660 ! positive regulation of cell fate specification relationship: positively_regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010064 name: embryonic shoot morphogenesis namespace: biological_process def: "The process in which the anatomical structures of embryonic shoot are generated and organized." [GOC:tb] is_a: GO:0010016 ! shoot morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010065 name: primary meristem tissue development namespace: biological_process def: "The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium." [GOC:tb, ISBN:0471245208] synonym: "primary meristem histogenesis" EXACT [] is_a: GO:0048508 ! embryonic meristem development [Term] id: GO:0010066 name: ground meristem histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010067 name: procambium histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010068 name: protoderm histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010069 name: zygote asymmetric cytokinesis in embryo sac namespace: biological_process def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429] is_a: GO:0010070 ! zygote asymmetric cell division is_a: GO:0033205 ! cell cycle cytokinesis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010070 name: zygote asymmetric cell division namespace: biological_process def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] synonym: "zygote asymmetric cytokinesis" RELATED [] is_a: GO:0008356 ! asymmetric cell division [Term] id: GO:0010071 name: root meristem specification namespace: biological_process def: "The specification of a meristem which will give rise to a primary or lateral root." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010014 ! meristem initiation relationship: part_of GO:0010015 ! root morphogenesis relationship: part_of GO:0048508 ! embryonic meristem development [Term] id: GO:0010072 name: primary shoot apical meristem specification namespace: biological_process def: "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers." [GOC:ascb_2009, GOC:dph, GOC:tair_curators, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010014 ! meristem initiation relationship: part_of GO:0010016 ! shoot morphogenesis relationship: part_of GO:0048508 ! embryonic meristem development [Term] id: GO:0010073 name: meristem maintenance namespace: biological_process def: "Any process involved in maintaining the identity, size and shape of a meristem." [GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0010074 name: maintenance of meristem identity namespace: biological_process alt_id: GO:0032503 def: "The process in which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:tb] synonym: "maintenance of meristem cell identity" EXACT [] synonym: "meristem cell maintenance" EXACT [] is_a: GO:0019827 ! stem cell maintenance relationship: part_of GO:0010073 ! meristem maintenance [Term] id: GO:0010075 name: regulation of meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a meristem." [GOC:tb] synonym: "regulation of meristem size" EXACT [GOC:tb] is_a: GO:0048509 ! regulation of meristem development is_a: GO:0048638 ! regulation of developmental growth relationship: part_of GO:0010073 ! meristem maintenance relationship: regulates GO:0035266 ! meristem growth [Term] id: GO:0010076 name: maintenance of floral meristem identity namespace: biological_process def: "The process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010077 name: maintenance of inflorescence meristem identity namespace: biological_process def: "The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010078 name: maintenance of root meristem identity namespace: biological_process def: "The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity relationship: part_of GO:0010015 ! root morphogenesis [Term] id: GO:0010079 name: maintenance of vegetative meristem identity namespace: biological_process def: "The process in which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010080 name: regulation of floral meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a floral meristem." [GOC:tb] synonym: "regulation of floral meristem size" EXACT [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0010075 ! regulation of meristem growth relationship: regulates GO:0010451 ! floral meristem growth [Term] id: GO:0010081 name: regulation of inflorescence meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of an inflorescence meristem." [GOC:tb] synonym: "regulation of inflorescence meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0010450 ! inflorescence meristem growth [Term] id: GO:0010082 name: regulation of root meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a root meristem." [GOC:tb] synonym: "regulation of root meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:2000280 ! regulation of root development relationship: part_of GO:0010015 ! root morphogenesis relationship: regulates GO:0010449 ! root meristem growth [Term] id: GO:0010083 name: regulation of vegetative meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a vegetative meristem." [GOC:tb] synonym: "regulation of vegetative meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048831 ! regulation of shoot development relationship: regulates GO:0010448 ! vegetative meristem growth [Term] id: GO:0010084 name: specification of organ axis polarity namespace: biological_process def: "The process in which the polarity of an organ axis is specified." [GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009887 ! organ morphogenesis [Term] id: GO:0010085 name: polarity specification of proximal/distal axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the proximal/distal axis." [GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009946 ! proximal/distal axis specification [Term] id: GO:0010086 name: embryonic root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic root are generated and organized." [GOC:tb] is_a: GO:0010015 ! root morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010087 name: phloem or xylem histogenesis namespace: biological_process def: "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "phloem or xylem histogenesis" EXACT [GOC:tb] synonym: "vascular tissue development" BROAD [] synonym: "vascular tissue histogenesis" EXACT [] is_a: GO:0009888 ! tissue development [Term] id: GO:0010088 name: phloem development namespace: biological_process def: "The formation of the principal food-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] synonym: "phloem histogenesis" EXACT [GOC:tb] is_a: GO:0010087 ! phloem or xylem histogenesis [Term] id: GO:0010089 name: xylem development namespace: biological_process def: "The formation of the principal water-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] synonym: "xylem histogenesis" EXACT [GOC:tb] is_a: GO:0010087 ! phloem or xylem histogenesis [Term] id: GO:0010090 name: trichome morphogenesis namespace: biological_process alt_id: GO:0048272 def: "The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] synonym: "trichome cell morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0010026 ! trichome differentiation [Term] id: GO:0010091 name: trichome branching namespace: biological_process alt_id: GO:0048274 def: "Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0010090 ! trichome morphogenesis [Term] id: GO:0010092 name: specification of organ identity namespace: biological_process def: "The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0003002 ! regionalization relationship: part_of GO:0048645 ! organ formation [Term] id: GO:0010093 name: specification of floral organ identity namespace: biological_process def: "The process in which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010092 ! specification of organ identity relationship: part_of GO:0048449 ! floral organ formation [Term] id: GO:0010094 name: specification of carpel identity namespace: biological_process def: "The process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048462 ! carpel formation [Term] id: GO:0010095 name: specification of petal identity namespace: biological_process def: "The process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048451 ! petal formation [Term] id: GO:0010096 name: specification of sepal identity namespace: biological_process def: "The process in which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048453 ! sepal formation [Term] id: GO:0010097 name: specification of stamen identity namespace: biological_process def: "The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048455 ! stamen formation [Term] id: GO:0010098 name: suspensor development namespace: biological_process def: "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm." [GOC:tb, ISBN:0471245208] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0010099 name: regulation of photomorphogenesis namespace: biological_process def: "Any process that modulates the rate or extent of photomorphogenesis." [GOC:tb] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000030 ! regulation of response to red or far red light relationship: regulates GO:0009640 ! photomorphogenesis [Term] id: GO:0010100 name: negative regulation of photomorphogenesis namespace: biological_process def: "Any process that stops, reduces or prevents photomorphogenesis." [GOC:tb] synonym: "down regulation of photomorphogenesis" EXACT [] synonym: "down-regulation of photomorphogenesis" EXACT [] synonym: "downregulation of photomorphogenesis" EXACT [] synonym: "inhibition of photomorphogenesis" NARROW [] is_a: GO:0010099 ! regulation of photomorphogenesis is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0009640 ! photomorphogenesis [Term] id: GO:0010101 name: post-embryonic root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed." [GOC:tb] is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0010015 ! root morphogenesis relationship: part_of GO:0048528 ! post-embryonic root development [Term] id: GO:0010102 name: lateral root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a lateral root are generated and organized. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators] is_a: GO:0010101 ! post-embryonic root morphogenesis relationship: part_of GO:0048527 ! lateral root development [Term] id: GO:0010103 name: stomatal complex morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [GOC:tair_curators] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0010016 ! shoot morphogenesis relationship: part_of GO:0010374 ! stomatal complex development [Term] id: GO:0010104 name: regulation of ethylene mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ethylene (ethene) mediated signaling." [GOC:tb] synonym: "regulation of ethene mediated signaling pathway" EXACT [] synonym: "regulation of ethene mediated signalling pathway" EXACT [] synonym: "regulation of ethylene mediated signalling pathway" EXACT [] is_a: GO:0070297 ! regulation of two-component signal transduction system (phosphorelay) relationship: regulates GO:0009873 ! ethylene mediated signaling pathway [Term] id: GO:0010105 name: negative regulation of ethylene mediated signaling pathway namespace: biological_process def: "Any process that stops or prevents ethylene (ethene) mediated signaling." [GOC:tb] synonym: "down regulation of ethylene mediated signaling pathway" EXACT [] synonym: "down-regulation of ethylene mediated signaling pathway" EXACT [] synonym: "downregulation of ethylene mediated signaling pathway" EXACT [] synonym: "inhibition of ethylene mediated signaling pathway" NARROW [] synonym: "negative regulation of ethene mediated signaling pathway" EXACT [] synonym: "negative regulation of ethene mediated signalling pathway" EXACT [] synonym: "negative regulation of ethylene mediated signalling pathway" EXACT [] is_a: GO:0010104 ! regulation of ethylene mediated signaling pathway is_a: GO:0070298 ! negative regulation of two-component signal transduction system (phosphorelay) relationship: negatively_regulates GO:0009873 ! ethylene mediated signaling pathway [Term] id: GO:0010106 name: cellular response to iron ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010107 name: potassium ion import namespace: biological_process def: "The directed movement of potassium ions into a cell or organelle." [GOC:sm] synonym: "potassium import" EXACT [] synonym: "potassium ion uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0071805 ! potassium ion transmembrane transport [Term] id: GO:0010108 name: detection of glutamine namespace: biological_process def: "The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "glutamine detection" EXACT [] synonym: "glutamine perception" RELATED [] synonym: "glutamine sensing" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0010109 name: regulation of photosynthesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm] subset: gosubset_prok is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0015979 ! photosynthesis [Term] id: GO:0010110 name: regulation of photosynthesis, dark reaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction." [GOC:sm] is_a: GO:0010109 ! regulation of photosynthesis is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process relationship: regulates GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0010111 name: glyoxysome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway." [GOC:tb] synonym: "glyoxysome organisation" EXACT [GOC:curators] synonym: "glyoxysome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0010112 name: regulation of systemic acquired resistance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of systemic acquired resistance." [GOC:sm] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0009627 ! systemic acquired resistance [Term] id: GO:0010113 name: negative regulation of systemic acquired resistance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of systemic acquired resistance." [GOC:sm] synonym: "down regulation of systemic acquired resistance" EXACT [] synonym: "down-regulation of systemic acquired resistance" EXACT [] synonym: "downregulation of systemic acquired resistance" EXACT [] synonym: "inhibition of systemic acquired resistance" NARROW [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0010112 ! regulation of systemic acquired resistance is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045824 ! negative regulation of innate immune response relationship: negatively_regulates GO:0009627 ! systemic acquired resistance [Term] id: GO:0010114 name: response to red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "response to red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010115 name: regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] subset: gosubset_prok synonym: "regulation of abscisic acid anabolism" EXACT [] synonym: "regulation of abscisic acid biosynthesis" EXACT [] synonym: "regulation of abscisic acid formation" EXACT [] synonym: "regulation of abscisic acid synthesis" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0009688 ! abscisic acid biosynthetic process [Term] id: GO:0010116 name: positive regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] subset: gosubset_prok synonym: "activation of abscisic acid biosynthetic process" NARROW [] synonym: "positive regulation of abscisic acid anabolism" EXACT [] synonym: "positive regulation of abscisic acid biosynthesis" EXACT [] synonym: "positive regulation of abscisic acid formation" EXACT [] synonym: "positive regulation of abscisic acid synthesis" EXACT [] synonym: "stimulation of abscisic acid biosynthetic process" NARROW [] synonym: "up regulation of abscisic acid biosynthetic process" EXACT [] synonym: "up-regulation of abscisic acid biosynthetic process" EXACT [] synonym: "upregulation of abscisic acid biosynthetic process" EXACT [] is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process relationship: positively_regulates GO:0009688 ! abscisic acid biosynthetic process [Term] id: GO:0010117 name: photoprotection namespace: biological_process def: "Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis." [GOC:mg] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0010118 name: stomatal movement namespace: biological_process def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0010119 name: regulation of stomatal movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stomatal movement." [GOC:sm] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0010118 ! stomatal movement [Term] id: GO:0010120 name: camalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin." [GOC:pz] synonym: "camalexin anabolism" EXACT [] synonym: "camalexin biosynthesis" EXACT [] synonym: "camalexin formation" EXACT [] synonym: "camalexin synthesis" EXACT [] xref: MetaCyc:CAMALEXIN-SYN is_a: GO:0009700 ! indole phytoalexin biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0052317 ! camalexin metabolic process [Term] id: GO:0010121 name: arginine catabolic process to proline via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine." [GOC:pz] subset: gosubset_prok synonym: "arginine breakdown to proline via ornithine" EXACT [] synonym: "arginine degradation to proline via ornithine" EXACT [] xref: MetaCyc:ARGORNPROST-PWY is_a: GO:0019493 ! arginine catabolic process to proline [Term] id: GO:0010122 name: arginine catabolic process to alanine via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine." [GOC:pz] subset: gosubset_prok synonym: "arginine breakdown to alanine via ornithine" EXACT [] synonym: "arginine degradation to alanine via ornithine" EXACT [] xref: MetaCyc:ARGORNPROST-PWY is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0010123 name: acetate catabolic process to butyrate, ethanol, acetone and butanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol." [GOC:pz] subset: gosubset_prok synonym: "acetate fermentation to butyrate, ethanol, acetone and butanol" EXACT [] xref: MetaCyc:CENTFERM-PWY is_a: GO:0019654 ! acetate fermentation [Term] id: GO:0010124 name: phenylacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylacetate." [GOC:pz] subset: gosubset_prok synonym: "phenylacetate breakdown" EXACT [] synonym: "phenylacetate catabolism" EXACT [] synonym: "phenylacetate degradation" EXACT [] xref: MetaCyc:PWY0-321 is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0010125 name: mycothiol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] subset: gosubset_prok synonym: "mycothiol anabolism" EXACT [] synonym: "mycothiol biosynthesis" EXACT [] synonym: "mycothiol formation" EXACT [] synonym: "mycothiol synthesis" EXACT [] xref: MetaCyc:PWY1G-0 xref: Reactome:879299 "Mycothiol biosynthesis" is_a: GO:0010126 ! mycothiol metabolic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0010126 name: mycothiol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] subset: gosubset_prok synonym: "mycothiol metabolism" EXACT [] xref: Reactome:870331 "Mycothiol metabolism" xref: Reactome:879325 "Mycothiol catabolism" is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0010127 name: mycothiol-dependent detoxification namespace: biological_process def: "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell." [GOC:pz] synonym: "mycothiol-dependent detoxification of alkylating agent" NARROW [] xref: MetaCyc:PWY1G-1 xref: MetaCyc:PWY1G-170 xref: Reactome:879235 "Mycothiol-dependent detoxification" is_a: GO:0009636 ! response to toxin [Term] id: GO:0010128 name: benzoate catabolic process via CoA ligation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GOC:pz] subset: gosubset_prok synonym: "anaerobic benzoate breakdown" EXACT [] synonym: "anaerobic benzoate catabolic process" EXACT [] synonym: "anaerobic benzoate catabolism" EXACT [] synonym: "anaerobic benzoate degradation" EXACT [] xref: MetaCyc:PWY-283 is_a: GO:0018875 ! anaerobic benzoate metabolic process is_a: GO:0043639 ! benzoate catabolic process [Term] id: GO:0010129 name: anaerobic cyclohexane-1-carboxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen." [GOC:pz] subset: gosubset_prok synonym: "anaerobic cyclohexane-1-carboxylate breakdown" EXACT [] synonym: "anaerobic cyclohexane-1-carboxylate catabolism" EXACT [] synonym: "anaerobic cyclohexane-1-carboxylate degradation" EXACT [] xref: MetaCyc:PWY-301 is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0010130 name: anaerobic ethylbenzene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GOC:pz] subset: gosubset_prok synonym: "anaerobic ethylbenzene breakdown" EXACT [] synonym: "anaerobic ethylbenzene catabolism" EXACT [] synonym: "anaerobic ethylbenzene degradation" EXACT [] xref: MetaCyc:PWY-481 is_a: GO:0018913 ! anaerobic ethylbenzene metabolic process [Term] id: GO:0010131 name: sucrose catabolic process, using invertase or sucrose synthase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase." [GOC:pz] subset: gosubset_prok synonym: "sucrose breakdown, using invertase or sucrose synthase" EXACT [] synonym: "sucrose catabolism, using invertase or sucrose synthase" EXACT [] synonym: "sucrose degradation, using invertase or sucrose synthase" EXACT [] xref: MetaCyc:PWY-3801 xref: MetaCyc:PWY-621 is_a: GO:0005987 ! sucrose catabolic process [Term] id: GO:0010132 name: dhurrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound." [GOC:pz] subset: gosubset_prok synonym: "dhurrin anabolism" EXACT [] synonym: "dhurrin biosynthesis" EXACT [] synonym: "dhurrin formation" EXACT [] synonym: "dhurrin synthesis" EXACT [] xref: MetaCyc:PWY-861 is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process [Term] id: GO:0010133 name: proline catabolic process to glutamate namespace: biological_process alt_id: GO:0019494 def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz] subset: gosubset_prok synonym: "proline breakdown to glutamate" EXACT [] synonym: "proline degradation to glutamate" EXACT [] synonym: "proline oxidation" RELATED [] xref: MetaCyc:PROUT-PWY xref: MetaCyc:PWY-4561 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006562 ! proline catabolic process [Term] id: GO:0010134 name: sulfate assimilation via adenylyl sulfate reduction namespace: biological_process def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2] subset: gosubset_prok synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT [] xref: MetaCyc:SULFMETII-PWY is_a: GO:0000103 ! sulfate assimilation is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0010135 name: ureide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants." [GOC:pz] subset: gosubset_prok synonym: "ureide metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0010136 name: ureide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium." [GOC:pz] subset: gosubset_prok synonym: "ureide breakdown" EXACT [] synonym: "ureide catabolism" EXACT [] synonym: "ureide degradation" EXACT [] xref: MetaCyc:URDEGR-PWY is_a: GO:0010135 ! ureide metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0010137 name: ureide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots." [GOC:pz] subset: gosubset_prok synonym: "ureide anabolism" EXACT [] synonym: "ureide biosynthesis" EXACT [] synonym: "ureide formation" EXACT [] synonym: "ureide synthesis" EXACT [] xref: MetaCyc:URSIN-PWY is_a: GO:0010135 ! ureide metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0010138 name: pyrimidine ribonucleotide salvage namespace: biological_process def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis." [GOC:pz] subset: gosubset_prok xref: MetaCyc:PWY0-163 is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage [Term] id: GO:0010139 name: pyrimidine deoxyribonucleotide salvage namespace: biological_process def: "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis." [GOC:pz] subset: gosubset_prok xref: MetaCyc:PWY0-181 is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage [Term] id: GO:0010140 name: adenine, hypoxanthine and their nucleoside salvage namespace: biological_process def: "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis." [GOC:pz] comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. is_obsolete: true replaced_by: GO:0006168 replaced_by: GO:0006169 replaced_by: GO:0006190 replaced_by: GO:0043103 [Term] id: GO:0010141 name: guanine, xanthine and their nucleoside salvage namespace: biological_process def: "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis." [GOC:pz] comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. is_obsolete: true replaced_by: GO:0006178 replaced_by: GO:0006179 replaced_by: GO:0006190 replaced_by: GO:0043103 [Term] id: GO:0010142 name: farnesyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922] subset: gosubset_prok synonym: "Ac-MVA pathway" NARROW [PMID:14517367] synonym: "acetate-mevalonate pathway" NARROW [PMID:14517367] synonym: "farnesyl diphosphate anabolism, mevalonate pathway" EXACT [] synonym: "farnesyl diphosphate formation, mevalonate pathway" EXACT [] synonym: "farnesyl diphosphate synthesis, mevalonate pathway" EXACT [] synonym: "isoprenoid pathway" EXACT [] xref: MetaCyc:PWY-922 is_a: GO:0045337 ! farnesyl diphosphate biosynthetic process relationship: part_of GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0010143 name: cutin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants." [ISBN:0028623819] synonym: "cutin anabolism" EXACT [] synonym: "cutin biosynthesis" EXACT [] synonym: "cutin formation" EXACT [] synonym: "cutin synthesis" EXACT [] xref: MetaCyc:PWY-321 is_a: GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0010144 name: pyridoxal phosphate biosynthetic process from pyridoxamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine." [GOC:pz] subset: gosubset_prok synonym: "pyridoxal phosphate anabolism from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate formation from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate synthesis from pyridoxamine" EXACT [] synonym: "vitamin B6 biosynthesis from pyridoxamine" EXACT [] synonym: "vitamin B6 biosynthetic process from pyridoxamine" EXACT [] is_a: GO:0042818 ! pyridoxamine metabolic process is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process [Term] id: GO:0010145 name: fructan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues." [GOC:sm] subset: gosubset_prok synonym: "fructan metabolism" EXACT [] synonym: "levan metabolic process" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0010146 name: fructan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues." [GOC:pz] subset: gosubset_prok synonym: "fructan anabolism" EXACT [] synonym: "fructan biosynthesis" EXACT [] synonym: "fructan formation" EXACT [] synonym: "fructan synthesis" EXACT [] synonym: "levan biosynthesis" EXACT [] synonym: "levan biosynthetic process" EXACT [] xref: MetaCyc:PWY-822 is_a: GO:0010145 ! fructan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0010147 name: fructan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues." [GOC:pz] subset: gosubset_prok synonym: "fructan breakdown" EXACT [] synonym: "fructan catabolism" EXACT [] synonym: "fructan degradation" EXACT [] synonym: "levan catabolic process" EXACT [] synonym: "levan catabolism" EXACT [] xref: MetaCyc:PWY-862 is_a: GO:0010145 ! fructan metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0010148 name: transpiration namespace: biological_process def: "Release of water by the plant into the air as water vapor mainly through leaves." [GOC:sm, ISBN:0879015322] xref: Wikipedia:Transpiration is_a: GO:0006833 ! water transport [Term] id: GO:0010149 name: senescence namespace: biological_process def: "OBSOLETE. A preprogrammed process associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components. An example of this process is found in Arabidopsis thaliana, when older leaves or floral organs are shed." [GOC:mtg_sensu, ISBN:0387987819] comment: This term was made obsolete because its name is ambiguous and it is covered by the two more specific terms: 'organ senescence ; GO:0010260' and 'cell aging ; GO:0007569'. xref: Wikipedia:Senescence is_obsolete: true [Term] id: GO:0010150 name: leaf senescence namespace: biological_process def: "The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism." [ISBN:0387987819] is_a: GO:0010260 ! organ senescence [Term] id: GO:0010151 name: chloroplast elongation namespace: biological_process def: "Expansion of the chloroplast that usually precedes division." [GOC:lr] is_a: GO:0009658 ! chloroplast organization [Term] id: GO:0010152 name: pollen maturation namespace: biological_process def: "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains." [PMID:11595796] is_a: GO:0021700 ! developmental maturation relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0010153 name: polar cell elongation namespace: biological_process def: "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion." [PMID:11978864] comment: This term was made obsolete because it did not represent a process discrete from its sibling terms. synonym: "polarity-dependent cell elongation" NARROW [] is_obsolete: true consider: GO:0042814 consider: GO:0042815 [Term] id: GO:0010154 name: fruit development namespace: biological_process def: "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant." [GOC:sm] is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0010155 name: regulation of proton transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm] is_a: GO:0043269 ! regulation of ion transport relationship: regulates GO:0015992 ! proton transport [Term] id: GO:0010156 name: sporocyte morphogenesis namespace: biological_process def: "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores." [PMID:10465788] comment: This term was made obsolete because it was incorrectly defined. is_obsolete: true consider: GO:0048533 [Term] id: GO:0010157 name: response to chlorate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010158 name: abaxial cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] is_a: GO:0001708 ! cell fate specification [Term] id: GO:0010159 name: specification of organ position namespace: biological_process def: "The regionalization process in which information that determines the correct position at which organ primordia are formed is generated and perceived resulting in correct positioning of the new organ." [PMID:9611175] is_a: GO:0003002 ! regionalization relationship: part_of GO:0009887 ! organ morphogenesis [Term] id: GO:0010160 name: formation of organ boundary namespace: biological_process alt_id: GO:0048862 def: "The regionalization process that specifies organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175] synonym: "organ boundary specification" EXACT [] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0048645 ! organ formation [Term] id: GO:0010161 name: red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "red light signalling pathway" EXACT [] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071491 ! cellular response to red light [Term] id: GO:0010162 name: seed dormancy namespace: biological_process def: "The process in which a dormant state is induced, maintained and broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated." [GOC:lr] xref: Wikipedia:Seed#Seed_dormancy_and_protection is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022611 ! dormancy process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0010431 ! seed maturation [Term] id: GO:0010163 name: high-affinity potassium ion import namespace: biological_process def: "The directed, energized, high affinity movement of potassium ions into a cell or organelle, driven by cation symport with hydrogen or sodium ions." [PMID:8893537] synonym: "high affinity potassium ion import" EXACT [] synonym: "high affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb] synonym: "high-affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0071805 ! potassium ion transmembrane transport [Term] id: GO:0010164 name: response to cesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:sm] synonym: "response to cesium" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010165 name: response to X-ray namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] synonym: "response to X-ray radiation stimulus" EXACT [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010166 name: wax metabolic process namespace: biological_process def: "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids." [GOC:sm] subset: gosubset_prok synonym: "wax metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0010167 name: response to nitrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010168 name: ER body namespace: cellular_component def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182] synonym: "endoplasmic reticulum body" EXACT [] is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0010169 name: thioglucosidase complex namespace: cellular_component def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349] synonym: "myrosinase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0010170 name: glucose-1-phosphate adenylyltransferase complex namespace: cellular_component def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0010171 name: body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0010172 name: embryonic body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic soma are generated and organized." [GOC:ems] is_a: GO:0010171 ! body morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010174 name: nucleoside transmembrane transporter activity, against a concentration gradient namespace: molecular_function def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb] synonym: "concentrative nucleoside transporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0010175 name: sphingosine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of amino alcohol sphingosine from one side of the membrane to the other." [GOC:tb] is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity [Term] id: GO:0010176 name: homogentisate phytyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol." [MetaCyc:RXN-2541, PMID:14512521] xref: KEGG:R07500 xref: MetaCyc:RXN-2541 is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010177 name: 2-(2'-methylthio)ethylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+." [MetaCyc:RXN-2202] synonym: "methylthioalkylmalate synthase activity" BROAD [MetaCyc:RXN-2202] xref: EC:2.3.3.- xref: MetaCyc:RXN-2202 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0010178 name: IAA-amino acid conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb] is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0010179 name: IAA-Ala conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine." [MetaCyc:RXN-2981] xref: MetaCyc:RXN-2981 is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010180 name: thioglucosidase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme thioglucosidase." [GOC:tb] synonym: "myrosinase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0010181 name: FMN binding namespace: molecular_function def: "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] subset: gosubset_prok synonym: "flavin mononucleotide binding" EXACT [] is_a: GO:0000166 ! nucleotide binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0010182 name: sugar mediated signaling pathway namespace: biological_process def: "The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes." [PMID:9014361] synonym: "sugar mediated signalling" EXACT [] is_a: GO:0009756 ! carbohydrate mediated signaling [Term] id: GO:0010183 name: pollen tube guidance namespace: biological_process def: "The process in which the growth of pollen tube is directed towards the female gametophyte." [GOC:lr] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0010184 name: cytokinin transport namespace: biological_process def: "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:lr] synonym: "cytokinin transmembrane transport" EXACT [GOC:mah] is_a: GO:0009914 ! hormone transport is_a: GO:0072530 ! purine-containing compound transmembrane transport [Term] id: GO:0010185 name: regulation of cellular defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "regulation of cellular defence response" EXACT [] is_a: GO:0031347 ! regulation of defense response relationship: regulates GO:0006968 ! cellular defense response [Term] id: GO:0010186 name: positive regulation of cellular defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "activation of cellular defense response" NARROW [] synonym: "positive regulation of cellular defence response" EXACT [] synonym: "stimulation of cellular defense response" NARROW [] synonym: "up regulation of cellular defense response" EXACT [] synonym: "up-regulation of cellular defense response" EXACT [] synonym: "upregulation of cellular defense response" EXACT [] is_a: GO:0010185 ! regulation of cellular defense response is_a: GO:0031349 ! positive regulation of defense response relationship: positively_regulates GO:0006968 ! cellular defense response [Term] id: GO:0010187 name: negative regulation of seed germination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination." [GOC:tb] synonym: "down regulation of seed germination" EXACT [] synonym: "down-regulation of seed germination" EXACT [] synonym: "downregulation of seed germination" EXACT [] synonym: "inhibition of seed germination" NARROW [] is_a: GO:0010029 ! regulation of seed germination is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0009845 ! seed germination [Term] id: GO:0010188 name: response to microbial phytotoxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants." [GOC:sm] is_a: GO:0009636 ! response to toxin [Term] id: GO:0010189 name: vitamin E biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:mg] subset: gosubset_prok synonym: "alpha-tocopherol biosynthesis" NARROW [] synonym: "alpha-tocopherol biosynthetic process" NARROW [] synonym: "tocopherol biosynthesis" EXACT [] synonym: "tocopherol biosynthetic process" EXACT [] synonym: "vitamin E anabolism" EXACT [] synonym: "vitamin E biosynthesis" EXACT [] synonym: "vitamin E formation" EXACT [] synonym: "vitamin E synthesis" EXACT [] xref: MetaCyc:PWY-1422 is_a: GO:0042360 ! vitamin E metabolic process is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process [Term] id: GO:0010190 name: cytochrome b6f complex assembly namespace: biological_process def: "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents." [GOC:tb] subset: gosubset_prok synonym: "cytochrome b6f complex biogenesis" EXACT [] is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0010191 name: mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm] subset: goslim_pir synonym: "mucilage metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0010192 name: mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants." [GOC:sm] synonym: "mucilage anabolism" EXACT [] synonym: "mucilage biosynthesis" EXACT [] synonym: "mucilage formation" EXACT [] synonym: "mucilage synthesis" EXACT [] is_a: GO:0010191 ! mucilage metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0010193 name: response to ozone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0010194 name: microRNA metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] comment: This term was made obsolete because it implies further processing of an end product rather than its production. is_obsolete: true replaced_by: GO:0035196 [Term] id: GO:0010195 name: microRNA biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] comment: This term was made obsolete because it represents a process that is not known to occur. synonym: "microRNA anabolism" EXACT [] synonym: "microRNA biosynthesis" EXACT [] synonym: "microRNA formation" EXACT [] synonym: "microRNA synthesis" EXACT [] synonym: "miRNA biosynthesis" EXACT [] synonym: "miRNA biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0035196 [Term] id: GO:0010196 name: nonphotochemical quenching namespace: biological_process def: "The process to maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage." [PMID:10667783] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0010197 name: polar nucleus fusion namespace: biological_process def: "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized." [GOC:mtg_plant, GOC:sm] is_a: GO:0000741 ! karyogamy relationship: part_of GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0010198 name: synergid death namespace: biological_process alt_id: GO:0048470 def: "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [GOC:isa_complete, GOC:sm, PMID:12215516] synonym: "synergid cell death" EXACT [] synonym: "synergid degeneration" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! developmental programmed cell death is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0009856 ! pollination [Term] id: GO:0010199 name: organ boundary specification between lateral organs and the meristem namespace: biological_process def: "The process in which boundaries between lateral organs and the meristem is established and maintained." [PMID:12068116] synonym: "organ boundary specification" BROAD [] is_a: GO:0010160 ! formation of organ boundary [Term] id: GO:0010200 name: response to chitin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm] is_a: GO:0009743 ! response to carbohydrate stimulus [Term] id: GO:0010201 name: response to continuous far red light stimulus by the high-irradiance response system namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence." [GOC:mtg_far_red, GOC:sm] is_a: GO:0010218 ! response to far red light [Term] id: GO:0010202 name: response to low fluence red light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] is_a: GO:0009645 ! response to low light intensity stimulus is_a: GO:0010114 ! response to red light [Term] id: GO:0010203 name: response to very low fluence red light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] is_a: GO:0010114 ! response to red light is_a: GO:0055122 ! response to very low light intensity stimulus [Term] id: GO:0010204 name: defense response signaling pathway, resistance gene-independent namespace: biological_process def: "A series of molecular signals that is activated during defense response and does not depend upon R-genes." [GOC:mah, GOC:sm] synonym: "defence response signaling pathway, resistance gene-independent" EXACT [] synonym: "defence response signalling pathway, resistance gene-independent" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0007165 ! signal transduction [Term] id: GO:0010205 name: photoinhibition namespace: biological_process def: "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II." [GOC:mtg_electron_transport, PMID:12068126] synonym: "photosystem II inhibition" BROAD [] xref: Wikipedia:Photoinhibition is_a: GO:0009644 ! response to high light intensity is_a: GO:0043155 ! negative regulation of photosynthesis, light reaction relationship: negatively_regulates GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0010206 name: photosystem II repair namespace: biological_process def: "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the Photosystem II following photoinhibition." [GOC:sm] is_a: GO:0030091 ! protein repair relationship: part_of GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0010207 name: photosystem II assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on thylakoid membrane. In plants, the photosystem II complex consists of over 20 polypeptides encoded by either nuclear or chloroplast genome." [GOC:pz] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0010208 name: pollen wall assembly namespace: biological_process def: "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine." [PMID:11743117] synonym: "pollen wall formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0045229 ! external encapsulating structure organization relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0010209 name: vacuolar sorting signal binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0010210 name: IAA-Phe conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine." [GOC:syr] is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010211 name: IAA-Leu conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine." [MetaCyc:RXN-2982] xref: MetaCyc:RXN-2982 is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010212 name: response to ionizing radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] synonym: "response to ionising radiation" EXACT [] synonym: "response to ionizing radiation stimulus" EXACT [] is_a: GO:0009314 ! response to radiation [Term] id: GO:0010213 name: non-photoreactive DNA repair namespace: biological_process def: "A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated." [GOC:syr] subset: gosubset_prok synonym: "light-independent DNA repair" EXACT [GOC:syr] is_a: GO:0006281 ! DNA repair [Term] id: GO:0010214 name: seed coat development namespace: biological_process def: "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010215 name: cellulose microfibril organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall." [GOC:mah, PMID:12468730] synonym: "cellulose microfibril organisation" EXACT [GOC:curators] is_a: GO:0030198 ! extracellular matrix organization relationship: part_of GO:0071668 ! plant-type cell wall assembly [Term] id: GO:0010216 name: maintenance of DNA methylation namespace: biological_process def: "Any process involved in maintaining the methylation state of a nucleotide sequence." [PMID:11898023] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006306 ! DNA methylation [Term] id: GO:0010217 name: cellular aluminum ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of aluminum ions at the level of a cell." [GOC:lr, GOC:mah] synonym: "cellular aluminium ion homeostasis" EXACT [GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055079 ! aluminum ion homeostasis [Term] id: GO:0010218 name: response to far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb] synonym: "response to far red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010219 name: regulation of vernalization response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] is_a: GO:0080134 ! regulation of response to stress relationship: regulates GO:0010048 ! vernalization response [Term] id: GO:0010220 name: positive regulation of vernalization response namespace: biological_process def: "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] synonym: "activation of vernalization response" NARROW [] synonym: "stimulation of vernalization response" NARROW [] synonym: "up regulation of vernalization response" EXACT [] synonym: "up-regulation of vernalization response" EXACT [] synonym: "upregulation of vernalization response" EXACT [] is_a: GO:0010219 ! regulation of vernalization response is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0010048 ! vernalization response [Term] id: GO:0010221 name: negative regulation of vernalization response namespace: biological_process def: "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] synonym: "down regulation of vernalization response" EXACT [] synonym: "down-regulation of vernalization response" EXACT [] synonym: "downregulation of vernalization response" EXACT [] synonym: "inhibition of vernalization response" NARROW [] is_a: GO:0010219 ! regulation of vernalization response is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0010048 ! vernalization response [Term] id: GO:0010222 name: stem vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the stem of vascular plants." [GOC:tb] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0010223 name: secondary shoot formation namespace: biological_process def: "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs." [GOC:tb, PMID:12815068] synonym: "auxiliary shoot formation" EXACT [] synonym: "axillary shoot formation" EXACT [] is_a: GO:0010346 ! shoot formation [Term] id: GO:0010224 name: response to UV-B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 290 to 320 nm." [GOC:tb] synonym: "response to medium wave ultraviolet light stimulus" EXACT [] synonym: "response to medium wave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-B light stimulus" EXACT [] synonym: "response to UV-B radiation stimulus" EXACT [] synonym: "response to UVB light stimulus" EXACT [] synonym: "response to UVB radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010225 name: response to UV-C namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 290 nm." [GOC:tb] synonym: "response to germicidal ultraviolet light stimulus" EXACT [] synonym: "response to germicidal ultraviolet radiation stimulus" EXACT [] synonym: "response to shortwave ultraviolet light stimulus" EXACT [] synonym: "response to shortwave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-C light stimulus" EXACT [] synonym: "response to UV-C radiation stimulus" EXACT [] synonym: "response to UVC light stimulus" EXACT [] synonym: "response to UVC radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010226 name: response to lithium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010227 name: floral organ abscission namespace: biological_process def: "The controlled shedding of floral organs." [PMID:12972671] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009838 ! abscission relationship: part_of GO:0048437 ! floral organ development [Term] id: GO:0010228 name: vegetative to reproductive phase transition of meristem namespace: biological_process def: "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence." [GOC:tb] synonym: "floral evocation" RELATED [DOI:10.1146/annurev.pp.39.060188.001135] synonym: "flowering" RELATED [] synonym: "transition from vegetative to reproductive phase" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0009791 ! post-embryonic development relationship: part_of GO:0048608 ! reproductive structure development [Term] id: GO:0010229 name: inflorescence development namespace: biological_process def: "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0009791 ! post-embryonic development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0010230 name: alternative respiration namespace: biological_process def: "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399] is_a: GO:0009060 ! aerobic respiration [Term] id: GO:0010231 name: maintenance of seed dormancy namespace: biological_process def: "Any process that maintains a seed in a dormant state." [PMID:9580097] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009737 ! response to abscisic acid stimulus is_a: GO:0022611 ! dormancy process relationship: part_of GO:0010162 ! seed dormancy [Term] id: GO:0010232 name: vascular transport namespace: biological_process def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm] is_a: GO:0006810 ! transport is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0010233 name: phloem transport namespace: biological_process def: "The directed movement of substances, into, out of or within a cell, either in a phloem tissue or in the phloem membrane." [GOC:sm] is_a: GO:0010232 ! vascular transport [Term] id: GO:0010234 name: tapetal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] is_a: GO:0001708 ! cell fate specification is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048657 ! tapetal cell differentiation [Term] id: GO:0010235 name: guard mother cell cytokinesis namespace: biological_process def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb] synonym: "guard mother cell division" EXACT [] is_a: GO:0000911 ! cytokinesis by cell plate formation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010236 name: plastoquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast." [GOC:sm] synonym: "plastoquinone anabolism" EXACT [] synonym: "plastoquinone biosynthesis" EXACT [] synonym: "plastoquinone formation" EXACT [] synonym: "plastoquinone synthesis" EXACT [] xref: MetaCyc:PWY-1581 is_a: GO:0045426 ! quinone cofactor biosynthetic process [Term] id: GO:0010238 name: response to proline namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:sm] is_a: GO:0043200 ! response to amino acid stimulus [Term] id: GO:0010239 name: chloroplast mRNA processing namespace: biological_process def: "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs." [GOC:tb, PMID:9648738] is_a: GO:0006397 ! mRNA processing is_a: GO:0031425 ! chloroplast RNA processing [Term] id: GO:0010240 name: plastid pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637] synonym: "dehydrogenase complex" BROAD [] is_a: GO:0044435 ! plastid part is_a: GO:0045254 ! pyruvate dehydrogenase complex [Term] id: GO:0010241 name: ent-kaurene oxidation to kaurenoic acid namespace: biological_process def: "The three successive oxidations of the 4-methyl group of ent-kaurene to form ent-kaur-16-en-19-oate, kaurenoic acid. This process may be carried out entirely by the enzyme ent-kaurene oxidase." [EC:1.14.13.78 "ent-kaurene oxidase", GOC:tb] comment: Note that this term was in molecular function but was moved to biological process as it represents three successive reactions. synonym: "ent-kaurene oxidation to ent-kaur-16-en-19-oate" EXACT [] synonym: "ent-kaurene oxidation to ent-kaurenoate" EXACT [] synonym: "ent-kaurene oxidation to kaurenoic acid by ent-kaurene oxidase" EXACT [] xref: EC:1.14.13.78 is_a: GO:0033331 ! ent-kaurene metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0010242 name: oxygen evolving activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862] synonym: "photosynthetic water oxidation" EXACT [] xref: MetaCyc:PSII-RXN xref: MetaCyc:RXN0-5265 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0010243 name: response to organic nitrogen namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic nitrogen stimulus. An organic nitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [CHEBI:35352, PMID:9869419] synonym: "response to organonitrogen compound" EXACT [CHEBI:35352] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0010244 name: response to low fluence blue light stimulus by blue low-fluence system namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes." [GOC:mtg_far_red, PMID:10398709] synonym: "response to low fluence blue light" BROAD [] synonym: "response to low fluence blue light by blf system" EXACT [] is_a: GO:0009637 ! response to blue light is_a: GO:0009645 ! response to low light intensity stimulus [Term] id: GO:0010245 name: radial microtubular system formation namespace: biological_process def: "Formation of radial microtubular systems during male meiotic cytokinesis in plants." [GOC:syr] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0010246 name: rhamnogalacturonan I biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." [GOC:pz] synonym: "rhamnogalacturonan I anabolism" EXACT [] synonym: "rhamnogalacturonan I biosynthesis" EXACT [] synonym: "rhamnogalacturonan I formation" EXACT [] synonym: "rhamnogalacturonan I synthesis" EXACT [] is_a: GO:0045489 ! pectin biosynthetic process [Term] id: GO:0010247 name: detection of phosphate ion namespace: biological_process def: "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "phosphate ion detection" EXACT [] synonym: "phosphate ion perception" RELATED [] synonym: "phosphate ion sensing" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0010248 name: establishment or maintenance of transmembrane electrochemical gradient namespace: biological_process def: "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:sm] is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0010249 name: auxin conjugate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin." [GOC:sm] synonym: "auxin conjugate metabolism" EXACT [] is_a: GO:0009850 ! auxin metabolic process [Term] id: GO:0010250 name: S-methylmethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [PMID:12692340] synonym: "S-methylmethionine anabolism" EXACT [] synonym: "S-methylmethionine biosynthesis" EXACT [] synonym: "S-methylmethionine formation" EXACT [] synonym: "S-methylmethionine synthesis" EXACT [] is_a: GO:0033477 ! S-methylmethionine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0010252 name: auxin homeostasis namespace: biological_process def: "A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation." [http://diss-epsilon.slu.se/archive/00000215/] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010253 name: UDP-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [PMID:15134748] synonym: "UDP-rhamnose anabolism" EXACT [] synonym: "UDP-rhamnose biosynthesis" EXACT [] synonym: "UDP-rhamnose formation" EXACT [] synonym: "UDP-rhamnose synthesis" EXACT [] xref: MetaCyc:PWY-3261 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033478 ! UDP-rhamnose metabolic process [Term] id: GO:0010254 name: nectary development namespace: biological_process def: "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure." [GOC:lr] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010255 name: glucose mediated signaling pathway namespace: biological_process def: "The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes." [GOC:sm] synonym: "glucose mediated signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling is_a: GO:0071333 ! cellular response to glucose stimulus [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] synonym: "endomembrane organization" EXACT [GOC:curators] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0010257 name: NADH dehydrogenase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0010258 name: NADH dehydrogenase complex (plastoquinone) assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I." [PMID:15608332] is_a: GO:0010257 ! NADH dehydrogenase complex assembly [Term] id: GO:0010259 name: multicellular organismal aging namespace: biological_process def: "The inherent decline of a multicellular organism over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu, GOC:sm] is_a: GO:0007568 ! aging relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0010260 name: organ senescence namespace: biological_process alt_id: GO:0010261 def: "The process that occurs in an organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:sm] is_a: GO:0007568 ! aging relationship: part_of GO:0048513 ! organ development [Term] id: GO:0010262 name: somatic embryogenesis namespace: biological_process def: "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes." [GOC:sm, PMID:9611173] is_a: GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010263 name: tricyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings." [GOC:ct] synonym: "tricyclic triterpenoid anabolism" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid formation" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid synthesis" EXACT [GOC:tair_curators] is_a: GO:0010683 ! tricyclic triterpenoid metabolic process is_a: GO:0016104 ! triterpenoid biosynthetic process [Term] id: GO:0010264 name: myo-inositol hexakisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [CHEBI:17401, PMID:16107538] synonym: "myo-inositol hexakisphosphate anabolism" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis" EXACT [] synonym: "myo-inositol hexakisphosphate formation" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis" EXACT [] synonym: "phytate biosynthesis" EXACT [] synonym: "phytate biosynthetic process" EXACT [] is_a: GO:0032958 ! inositol phosphate biosynthetic process is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process [Term] id: GO:0010265 name: SCF complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex." [GOC:pz] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0010266 name: response to vitamin B1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz] synonym: "response to thiamin" EXACT [] synonym: "response to thiamine" EXACT [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0010267 name: production of ta-siRNAs involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs." [GOC:tb, PMID:16129836] synonym: "RNA interference, production of ta-siRNAs" EXACT [GOC:mah] is_a: GO:0030422 ! production of siRNA involved in RNA interference [Term] id: GO:0010268 name: brassinosteroid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of brassinosteroids within an organism or cell." [PMID:15908602] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010269 name: response to selenium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010270 name: photosystem II oxygen evolving complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on thylakoid membrane. In plants, the photosystem II OEC consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ; and protects the CaMn4 cluster bound to D1 and CP43 proteins." [PMID:16282331] synonym: "OEC (PSII) ASSEMBLY" EXACT [PMID:16282331] is_a: GO:0010207 ! photosystem II assembly [Term] id: GO:0010271 name: regulation of chlorophyll catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll." [PMID:16361392] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0090056 ! regulation of chlorophyll metabolic process relationship: regulates GO:0015996 ! chlorophyll catabolic process [Term] id: GO:0010272 name: response to silver ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010273 name: detoxification of copper ion namespace: biological_process def: "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion." [PMID:16367966] is_a: GO:0009636 ! response to toxin is_a: GO:0046688 ! response to copper ion [Term] id: GO:0010274 name: hydrotropism namespace: biological_process def: "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant." [ISBN:0395825172] xref: Wikipedia:Hydrotropism is_a: GO:0009606 ! tropism [Term] id: GO:0010275 name: NAD(P)H dehydrogenase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool." [GOC:sm] synonym: "NAD(P)H dehydrogenase complex (plastoquinone) assembly" NARROW [] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0010276 name: phytol kinase activity namespace: molecular_function def: "Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+." [MetaCyc:RXN-7683] xref: EC:2.7.1.- xref: MetaCyc:RXN-7683 is_a: GO:0016301 ! kinase activity [Term] id: GO:0010277 name: chlorophyllide a oxygenase [overall] activity namespace: molecular_function alt_id: GO:0046407 def: "Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+." [EC:1.13.12.14, MetaCyc:RXN-7677] comment: This is a process composed of two reactions represented by the terms 'GO:0052606 : chlorophyllide a oxygenase activity' and 'GO:0052607 : 7-hydroxy-chlorophyllide a oxygenase activity'. synonym: "CAO activity" BROAD [EC:1.13.12.14] synonym: "chlorophyll a oxygenation activity" EXACT [] synonym: "chlorophyll b synthesis activity" EXACT [] synonym: "chlorophyll-b synthesis activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide a:oxygen 7-oxidoreduction activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide-a oxygenation activity" EXACT [EC:1.13.12.14] xref: EC:1.13.12.14 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0010278 name: chloroplast outer membrane translocon namespace: cellular_component def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0010279 name: indole-3-acetic acid amido synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate." [PMID:15659623] synonym: "IAA amido synthetase activity" EXACT [] synonym: "IAA amino acid conjugate synthetase activity" EXACT [GOC:kad] synonym: "IAA amino acid synthetase activity" EXACT [GOC:kad] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0010280 name: UDP-L-rhamnose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O." [MetaCyc:RXN-5482, PMID:14701918] synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" NARROW [GOC:tb] xref: MetaCyc:RXN-5482 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0010282 name: senescence-associated vacuole namespace: cellular_component def: "A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448] synonym: "senescence associated vacuole" EXACT [GOC:curators] is_a: GO:0000323 ! lytic vacuole is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0010283 name: pinoresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+." [PMID:10066819, PMID:7592828] xref: MetaCyc:RXN-8678 xref: MetaCyc:RXN-8683 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0010284 name: lariciresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828] xref: MetaCyc:RXN-8679 xref: MetaCyc:RXN-8684 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0010285 name: L,L-diaminopimelate aminotransferase activity namespace: molecular_function alt_id: GO:0043742 def: "Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H(2)O + H(+)." [EC:2.6.1.83, RHEA:23991] synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [] synonym: "LL-DAP aminotransferase activity" EXACT [EC:2.6.1.83] synonym: "LL-DAP-AT activity" EXACT [EC:2.6.1.83] synonym: "LL-diaminopimelate aminotransferase activity" EXACT [] synonym: "LL-diaminopimelate transaminase activity" EXACT [EC:2.6.1.83] xref: EC:2.6.1.83 xref: KEGG:R07613 xref: MetaCyc:RXN-7737 xref: RHEA:23991 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0010286 name: heat acclimation namespace: biological_process def: "Any process that increases heat tolerance of an organism in response to high temperatures." [GOC:tair_curators] is_a: GO:0009408 ! response to heat [Term] id: GO:0010287 name: plastoglobule namespace: cellular_component alt_id: GO:0010502 def: "A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:tair_curators, PMID:16461379] synonym: "PG" EXACT [] synonym: "plastoglobuli" EXACT [] is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0010288 name: response to lead ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:tair_curators, PMID:16461380] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010289 name: homogalacturonan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [PMID:12913136, PMID:16540543] xref: MetaCyc:PWY-1061 is_a: GO:0045489 ! pectin biosynthetic process [Term] id: GO:0010290 name: chlorophyll catabolite transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of the membrane to the other." [PMID:9681016] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0010291 name: carotene beta-ring hydroxylase activity namespace: molecular_function alt_id: GO:0042411 def: "Catalysis of C3-hydroxylation of the beta-ring of various carotenes." [MetaCyc:MONOMER-12386, PMID:16492736] synonym: "beta-carotene hydroxylase activity" NARROW [] is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0010292 name: GTP:GDP antiporter activity namespace: molecular_function def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0010293 name: abscisic aldehyde oxidase activity namespace: molecular_function alt_id: GO:0033725 def: "Catalysis of the reaction: (+)-abscisic aldehyde + H(2)O + O(2) = abscisate + H(2)O(2) + H(+)." [EC:1.2.3.14, RHEA:20532] synonym: "AAO3" RELATED [EC:1.2.3.14] synonym: "abscisic-aldehyde oxidase activity" EXACT [EC:1.2.3.14] synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.14] synonym: "AOdelta" RELATED [EC:1.2.3.14] xref: EC:1.2.3.14 xref: KEGG:R06957 xref: MetaCyc:1.2.3.14-RXN xref: RHEA:20532 is_a: GO:0018488 ! aryl-aldehyde oxidase activity [Term] id: GO:0010294 name: abscisic acid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062] xref: MetaCyc:RXN-8155 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0010295 name: (+)-abscisic acid 8'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-abscisate + H(+) + NADPH + O(2) = (+)-8'-hydroxyabscisate + H(2)O + NADP(+)." [EC:1.14.13.93, RHEA:12900] synonym: "(+)-ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] synonym: "ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED [] synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" EXACT [EC:1.14.13.93] synonym: "abscisic acid 8'-hydroxylase activity" EXACT [] xref: EC:1.14.13.93 xref: KEGG:R07202 xref: MetaCyc:1.14.13.93-RXN xref: RHEA:12900 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0010296 name: prenylcysteine methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+." [MetaCyc:RXN-8409, PMID:16870359] xref: EC:3.1.1.- xref: MetaCyc:RXN-8409 is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0010297 name: heteropolysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with heteropolysaccharides. A heteropolysaccharide is a glycan composed of more than one type of monosaccharide residue." [PMID:16640603] synonym: "heteroglycan binding" EXACT [GOC:curators] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0010298 name: dihydrocamalexic acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+." [MetaCyc:RXN-8275, PMID:16766671] xref: MetaCyc:RXN-8275 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0010299 name: detoxification of cobalt ion namespace: biological_process def: "Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion." [GOC:tair_curators] is_a: GO:0009636 ! response to toxin [Term] id: GO:0010301 name: xanthoxin dehydrogenase activity namespace: molecular_function alt_id: GO:0033710 def: "Catalysis of the reaction: NAD(+) + xanthoxin = (+)-abscisic aldehyde + H(+) + NADH." [EC:1.1.1.288, RHEA:12551] synonym: "ABA2" RELATED [EC:1.1.1.288] synonym: "xanthoxin oxidase activity" EXACT [EC:1.1.1.288] synonym: "xanthoxin:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.288] xref: EC:1.1.1.288 xref: KEGG:R06954 xref: MetaCyc:1.1.1.288-RXN xref: RHEA:12551 is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0010302 name: 2-oxoglutarate-dependent dioxygenase activity namespace: molecular_function def: "Hydroxylase, with 2-oxoglutarate as one donor, and incorporation or reduction of one atom each of oxygen into both donors." [EC:1.14.11.-, PMID:16140259] is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0010303 name: limit dextrinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142] synonym: "amylopectin-1,6-glucosidase activity" EXACT [EC:3.2.1.142] synonym: "dextrin alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.142] synonym: "R-enzyme" RELATED [EC:3.2.1.142] xref: EC:3.2.1.142 xref: MetaCyc:3.2.1.10-RXN xref: MetaCyc:3.2.1.142-RXN xref: MetaCyc:RXN-1824 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0010304 name: PSII associated light-harvesting complex II catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:mah, PMID:16157880] synonym: "LHCII catabolism" RELATED [] is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0010305 name: leaf vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the leaf of vascular plants." [GOC:tair_curators] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0010306 name: rhamnogalacturonan II biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms." [PMID:12754267] is_a: GO:0045489 ! pectin biosynthetic process [Term] id: GO:0010307 name: acetylglutamate kinase regulator activity namespace: molecular_function def: "Modulates the enzyme activity of acetylglutamate kinase." [PMID:16377628] is_a: GO:0019207 ! kinase regulator activity [Term] id: GO:0010308 name: acireductone dioxygenase (Ni2+-requiring) activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + CO + formate." [EC:1.13.11.53, RHEA:14164] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" EXACT [EC:1.13.11.53] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "ARD activity" RELATED [EC:1.13.11.53] synonym: "E-2 activity" RELATED [EC:1.13.11.53] xref: EC:1.13.11.53 xref: KEGG:R07363 xref: MetaCyc:R146-RXN xref: RHEA:14164 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010309 name: acireductone dioxygenase [iron(II)-requiring] activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+)." [EC:1.13.11.54, RHEA:24507] subset: gosubset_prok synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT [] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" EXACT [EC:1.13.11.54] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD [] synonym: "aci-reductone dioxygenase" BROAD [] synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT [] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54] synonym: "ARD'" RELATED [] synonym: "ARD1" RELATED [] synonym: "E-2'" RELATED [] xref: EC:1.13.11.54 xref: KEGG:R07364 xref: MetaCyc:R147-RXN xref: RHEA:24507 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010310 name: regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119] synonym: "regulation of hydrogen peroxide metabolism" EXACT [] is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process relationship: regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010311 name: lateral root formation namespace: biological_process def: "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010102 ! lateral root morphogenesis [Term] id: GO:0010312 name: detoxification of zinc ion namespace: biological_process def: "Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators] is_a: GO:0009636 ! response to toxin is_a: GO:0010043 ! response to zinc ion [Term] id: GO:0010313 name: phytochrome binding namespace: molecular_function def: "Interacting selectively and non-covalently with phytochrome." [PMID:15486102] is_a: GO:0005515 ! protein binding [Term] id: GO:0010314 name: phosphatidylinositol-5-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0010315 name: auxin efflux namespace: biological_process def: "The process involved in the transport of auxin out of the cell." [GOC:tair_curators] synonym: "auxin export" EXACT [] is_a: GO:0060918 ! auxin transport relationship: part_of GO:0009734 ! auxin mediated signaling pathway [Term] id: GO:0010316 name: pyrophosphate-dependent phosphofructokinase complex namespace: cellular_component def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409] subset: goslim_pir synonym: "PFK complex" RELATED [] is_a: GO:0043234 ! protein complex [Term] id: GO:0010317 name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex namespace: cellular_component def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, alpha-subunit" RELATED [] is_a: GO:0043234 ! protein complex relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: GO:0010318 name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex namespace: cellular_component def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, beta-subunit" RELATED [] is_a: GO:0043234 ! protein complex relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: GO:0010319 name: stromule namespace: cellular_component def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010] synonym: "Stroma-filled tubule" RELATED [] xref: Wikipedia:Stromule is_a: GO:0044435 ! plastid part relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0010320 name: arginine/lysine endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators] comment: This term was made obsolete because it was defined incorrectly: there are no known peptidases using a catalytic mechanism involving arginine and lysine, and the Arabidopsis metacaspases that prompted addition of this term are in fact cysteine-type endopeptidases. is_obsolete: true replaced_by: GO:0004175 replaced_by: GO:0004197 [Term] id: GO:0010321 name: regulation of vegetative phase change namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tair_curators] is_a: GO:0048580 ! regulation of post-embryonic development relationship: regulates GO:0010050 ! vegetative phase change [Term] id: GO:0010322 name: regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process relationship: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway [Term] id: GO:0010323 name: negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] synonym: "down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" NARROW [] is_a: GO:0010322 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process relationship: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway [Term] id: GO:0010324 name: membrane invagination namespace: biological_process def: "The infolding of a membrane, resulting in formation of a vesicle." [GOC:tb] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0010325 name: raffinose family oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization)." [GOC:tair_curators] synonym: "raffinose family oligosaccharide biosynthesis" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process [Term] id: GO:0010326 name: methionine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid." [MetaCyc:RXN-2201, PMID:17056707] xref: EC:2.6.1.- xref: MetaCyc:RXN-2201 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0010327 name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883] synonym: "hexenol acetyltransferase" RELATED [] is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0010328 name: auxin influx transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804] synonym: "auxin influx facilitator" RELATED [] is_a: GO:0080161 ! auxin transmembrane transporter activity [Term] id: GO:0010329 name: auxin efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804] synonym: "auxin efflux carrier" RELATED [] synonym: "auxin efflux facilitator" RELATED [] is_a: GO:0015562 ! efflux transmembrane transporter activity is_a: GO:0080161 ! auxin transmembrane transporter activity [Term] id: GO:0010330 name: cellulose synthase complex namespace: cellular_component def: "The multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238] is_a: GO:0043234 ! protein complex [Term] id: GO:0010331 name: gibberellin binding namespace: molecular_function def: "Interacting selectively and non-covalently with gibberellins, plant hormones that regulate aspects of plant growth." [GOC:tair_curators] synonym: "gibberellic acid receptor" RELATED [] synonym: "gibberellin receptor" RELATED [] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0010332 name: response to gamma radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray] synonym: "response to gamma ray" RELATED [] synonym: "response to gamma-ray photon" RELATED [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010333 name: terpene synthase activity namespace: molecular_function def: "Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units." [EC:4.2.3.-, GOC:tair_curators] is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0010334 name: sesquiterpene synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons." [EC:4.2.3.-, GOC:tair_curators] is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0010335 name: response to non-ionic osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0010336 name: gibberellic acid homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation." [PMID:17194763] synonym: "gibberellin homeostasis" BROAD [] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010337 name: regulation of salicylic acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119] synonym: "regulation of salicylic acid metabolism" RELATED [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process relationship: regulates GO:0009696 ! salicylic acid metabolic process [Term] id: GO:0010338 name: leaf formation namespace: biological_process def: "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators] is_a: GO:0048645 ! organ formation relationship: part_of GO:0009965 ! leaf morphogenesis [Term] id: GO:0010339 name: external side of cell wall namespace: cellular_component def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0010340 name: carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201] is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0010341 name: gibberellin carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + GA = S-adenosyl-L-homocysteine + GA methyl ester." [PMID:17220201] is_a: GO:0010340 ! carboxyl-O-methyltransferase activity [Term] id: GO:0010342 name: endosperm cellularization namespace: biological_process def: "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization." [PMID:12421698] synonym: "cellularization of endosperm" EXACT [] is_a: GO:0007349 ! cellularization [Term] id: GO:0010343 name: singlet oxygen-mediated programmed cell death namespace: biological_process def: "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [PMID:17075038] synonym: "light-dependent programmed cell death" BROAD [] is_a: GO:0012501 ! programmed cell death [Term] id: GO:0010344 name: seed oilbody biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination." [GOC:jl, PMID:16877495] synonym: "oleosome biogenesis" RELATED [] synonym: "seed oil body organization" EXACT [] synonym: "spherosome biogenesis" RELATED [] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0071843 ! cellular component biogenesis at cellular level relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010345 name: suberin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols." [PMID:17259262] xref: MetaCyc:PWY-1121 is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0009699 ! phenylpropanoid biosynthetic process [Term] id: GO:0010346 name: shoot formation namespace: biological_process def: "The process that gives rise to a shoot. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010016 ! shoot morphogenesis [Term] id: GO:0010347 name: L-galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667] xref: MetaCyc:RXNQT-4142 is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity [Term] id: GO:0010348 name: lithium:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011] synonym: "lithium:proton antiporter activity" EXACT [GOC:mah] is_a: GO:0005451 ! monovalent cation:hydrogen antiporter activity [Term] id: GO:0010349 name: L-galactose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629] synonym: "L-galactose 1-dehydrogenase activity" RELATED [] xref: MetaCyc:RXN-1884 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0010350 name: cellular response to magnesium starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium." [PMID:17270009] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010351 name: lithium ion transport namespace: biological_process def: "The directed movement of lithium ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:17270011] synonym: "lithium transport" EXACT [] is_a: GO:0015672 ! monovalent inorganic cation transport [Term] id: GO:0010352 name: lithium ion export namespace: biological_process def: "The directed movement of lithium ion out of a cell or organelle." [PMID:17270011] synonym: "lithium export" EXACT [] synonym: "lithium ion efflux" RELATED [] is_a: GO:0010351 ! lithium ion transport [Term] id: GO:0010353 name: response to trehalose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512] is_a: GO:0034285 ! response to disaccharide stimulus [Term] id: GO:0010354 name: homogentisate prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0010355 name: homogentisate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010356 name: homogentisate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010357 name: homogentisate solanesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010358 name: leaf shaping namespace: biological_process def: "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed." [GOC:tb, PMID:16971475] synonym: "leaf structural organization" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0009965 ! leaf morphogenesis [Term] id: GO:0010359 name: regulation of anion channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anion channel activity." [PMID:17319842] subset: gosubset_prok is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0044070 ! regulation of anion transport [Term] id: GO:0010360 name: negative regulation of anion channel activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] is_a: GO:0010359 ! regulation of anion channel activity is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity [Term] id: GO:0010361 name: regulation of anion channel activity by blue light namespace: biological_process def: "Any process in which blue light modulates the frequency, rate or extent of anion channel activity." [GOC:dph, GOC:tb, PMID:17319842] synonym: "regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010359 ! regulation of anion channel activity [Term] id: GO:0010362 name: negative regulation of anion channel activity by blue light namespace: biological_process def: "Any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] synonym: "inhibition by blue light of anion channel activity" NARROW [] synonym: "negative regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010360 ! negative regulation of anion channel activity is_a: GO:0010361 ! regulation of anion channel activity by blue light [Term] id: GO:0010363 name: regulation of plant-type hypersensitive response namespace: biological_process def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244] comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'. synonym: "regulation of HR" EXACT [] synonym: "regulation of HR-PCD" EXACT [] synonym: "regulation of plant hypersensitive response" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0009626 ! plant-type hypersensitive response [Term] id: GO:0010364 name: regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process relationship: regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010365 name: positive regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process relationship: positively_regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010366 name: negative regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process relationship: negatively_regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010367 name: extracellular isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators] subset: gosubset_prok is_a: GO:0043033 ! isoamylase complex is_a: GO:0044421 ! extracellular region part [Term] id: GO:0010368 name: chloroplast isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized." [GOC:tair_curators] subset: gosubset_prok is_a: GO:0043033 ! isoamylase complex is_a: GO:0044434 ! chloroplast part [Term] id: GO:0010369 name: chromocenter namespace: cellular_component def: "A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0010370 name: perinucleolar chromocenter namespace: cellular_component def: "A chromocenter adjacent to the nucleolus." [PMID:15805479] is_a: GO:0010369 ! chromocenter [Term] id: GO:0010371 name: regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010372 name: positive regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "positive regulation of gibberellic acid biosynthetic process " NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process relationship: positively_regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010373 name: negative regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process relationship: negatively_regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010374 name: stomatal complex development namespace: biological_process def: "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0009791 ! post-embryonic development is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0010375 name: stomatal complex patterning namespace: biological_process def: "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0003002 ! regionalization [Term] id: GO:0010376 name: stomatal complex formation namespace: biological_process def: "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010103 ! stomatal complex morphogenesis [Term] id: GO:0010377 name: guard cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere." [PMID:17259259] synonym: "stomatal cell fate commitment" RELATED [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0010052 ! guard cell differentiation [Term] id: GO:0010378 name: temperature compensation of the circadian clock namespace: biological_process def: "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099] subset: gosubset_prok synonym: "regulation of the circadian clock by temperature" RELATED [] is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0042752 ! regulation of circadian rhythm [Term] id: GO:0010379 name: phaseic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA)." [BioCyc:PWY-5271 "http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5271&detail-level=3"] xref: MetaCyc:PWY-5271 is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0010380 name: regulation of chlorophyll biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [PMID:17291312] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0090056 ! regulation of chlorophyll metabolic process relationship: regulates GO:0015995 ! chlorophyll biosynthetic process [Term] id: GO:0010381 name: attachment of peroxisome to chloroplast namespace: biological_process def: "The process in which a peroxisome is transported to, and/or maintained in, a location adjacent to the chloroplast." [PMID:17215364] is_a: GO:0051640 ! organelle localization [Term] id: GO:0010382 name: cellular cell wall macromolecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis, occurring at the level of the cell." [GOC:mah, GOC:tair_curators] subset: gosubset_prok synonym: "cellular cell wall macromolecule metabolism" EXACT [] is_a: GO:0044036 ! cell wall macromolecule metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0070882 ! cellular cell wall organization or biogenesis [Term] id: GO:0010383 name: cell wall polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall polysaccharides." [GOC:tair_curators] subset: gosubset_prok is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0044036 ! cell wall macromolecule metabolic process [Term] id: GO:0010384 name: cell wall proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] synonym: "cell wall proteoglycan metabolism" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process [Term] id: GO:0010385 name: double-stranded methylated DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded methylated DNA. Cytosine methylation in DNA is an important mechanism for establishing stable heritable epigenetic marks." [PMID:17242155] is_a: GO:0003690 ! double-stranded DNA binding [Term] id: GO:0010386 name: lateral root primordium development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral root primordium over time, which initiates the formation to the mature structure. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." [PMID:17259263] is_a: GO:0048527 ! lateral root development [Term] id: GO:0010387 name: signalosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a signalosome." [PMID:17307927] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0010388 name: cullin deneddylation namespace: biological_process def: "The modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1)." [PMID:17307927] is_a: GO:0000338 ! protein deneddylation [Term] id: GO:0010389 name: regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [PMID:17329565] synonym: "regulation of mitotic entry" EXACT [GOC:vw] is_a: GO:2000602 ! regulation of interphase of mitotic cell cycle relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0010390 name: histone monoubiquitination namespace: biological_process def: "The modification of histones by addition of a single ubiquitin group." [PMID:17329563] is_a: GO:0006513 ! protein monoubiquitination is_a: GO:0016574 ! histone ubiquitination [Term] id: GO:0010391 name: glucomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators] synonym: "glucomannan metabolism" EXACT [] is_a: GO:0006080 ! substituted mannan metabolic process [Term] id: GO:0010392 name: galactoglucomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units." [GOC:tair_curators] synonym: "galactoglucomannan metabolism" RELATED [] is_a: GO:0006080 ! substituted mannan metabolic process [Term] id: GO:0010393 name: galacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues." [GOC:tair_curators] synonym: "galacturonan metabolism" EXACT [] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:0052546 ! cell wall pectin metabolic process [Term] id: GO:0010394 name: homogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:tair_curators] synonym: "homogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010395 name: rhamnogalacturonan I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone." [GOC:tair_curators] synonym: "RGI metabolism" RELATED [] synonym: "rhamnogalacturonan I metabolism" EXACT [] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:0052546 ! cell wall pectin metabolic process [Term] id: GO:0010396 name: rhamnogalacturonan II metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] synonym: "rhamnogalacturonan II metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010397 name: apiogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(l->3)-D-apiose) side chains via O-2 or O-3 links." [GOC:tair_curators] synonym: "apiogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010398 name: xylogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues." [GOC:tair_curators] synonym: "xylogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010399 name: rhamnogalacturonan I backbone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone." [GOC:tair_curators] synonym: "rhamnogalacturonan I backbone metabolism" EXACT [] is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010400 name: rhamnogalacturonan I side chain metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I." [GOC:tair_curators] synonym: "rhamnogalacturonan I side chain metabolism" EXACT [] is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010401 name: pectic galactan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic galactan metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010402 name: pectic arabinan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabinan, a polymer with an alpha-(1->5)-linked -L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic arabinan metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process is_a: GO:0031221 ! arabinan metabolic process [Term] id: GO:0010403 name: pectic arabinogalactan I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1->4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic arabinogalactan I metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010404 name: cell wall hydroxyproline-rich glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] synonym: "cell wall hydroxyproline-rich glycoprotein metabolism" EXACT [] is_a: GO:0010384 ! cell wall proteoglycan metabolic process [Term] id: GO:0010405 name: arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." [GOC:tair_curators] synonym: "arabinogalactan protein metabolism" EXACT [] is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process [Term] id: GO:0010406 name: classical arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored." [GOC:tair_curators] synonym: "classical-arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010407 name: non-classical arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains." [GOC:tair_curators] synonym: "non-classical arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010408 name: fasciclin-like arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain." [GOC:tair_curators] synonym: "fasciclin-like arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010409 name: extensin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated." [GOC:tair_curators] synonym: "extensin metabolism" EXACT [] is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process [Term] id: GO:0010410 name: hemicellulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [GOC:tair_curators] subset: gosubset_prok synonym: "hemicellulose metabolism" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process [Term] id: GO:0010411 name: xyloglucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:tair_curators] synonym: "xyloglucan metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0010410 ! hemicellulose metabolic process [Term] id: GO:0010412 name: mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units." [GOC:tair_curators] subset: gosubset_prok synonym: "mannan metabolism" EXACT [] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0010410 ! hemicellulose metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0010413 name: glucuronoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units." [GOC:tair_curators] synonym: "glucuronoxylan metabolism" EXACT [] is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0010414 name: glucuronoarabinoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units." [GOC:tair_curators] synonym: "glucuronoarabinoxylan metabolism" EXACT [] is_a: GO:0010413 ! glucuronoxylan metabolic process is_a: GO:0010416 ! arabinoxylan metabolic process [Term] id: GO:0010415 name: unsubstituted mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units." [GOC:tair_curators] synonym: "unsubstituted mannan metabolism" EXACT [] is_a: GO:0010412 ! mannan metabolic process [Term] id: GO:0010416 name: arabinoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units." [GOC:tair_curators] synonym: "arabinoxylan metabolism" EXACT [] is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0010417 name: glucuronoxylan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues." [GOC:tair_curators] synonym: "glucuronoxylan anabolism" EXACT [] synonym: "glucuronoxylan biosynthesis" EXACT [] synonym: "glucuronoxylan formation" EXACT [] synonym: "glucuronoxylan synthesis" EXACT [] is_a: GO:0010413 ! glucuronoxylan metabolic process is_a: GO:0045492 ! xylan biosynthetic process [Term] id: GO:0010418 name: rhamnogalacturonan II backbone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] synonym: "rhamnogalacturonan II backbone metabolism" EXACT [] is_a: GO:0010394 ! homogalacturonan metabolic process is_a: GO:0010396 ! rhamnogalacturonan II metabolic process [Term] id: GO:0010419 name: rhamnogalacturonan II side chain metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively." [GOC:tair_curators] synonym: "rhamnogalacturonan II side chain metabolism" EXACT [] is_a: GO:0010396 ! rhamnogalacturonan II metabolic process [Term] id: GO:0010420 name: polyprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate + H+." [PMID:9628017] is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0010421 name: hydrogen peroxide-mediated programmed cell death namespace: biological_process def: "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [PMID:16036580] is_a: GO:0012501 ! programmed cell death [Term] id: GO:0010422 name: regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process relationship: regulates GO:0016132 ! brassinosteroid biosynthetic process [Term] id: GO:0010423 name: negative regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process relationship: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process [Term] id: GO:0010424 name: DNA methylation on cytosine within a CG sequence namespace: biological_process def: "The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600] synonym: "cytosine methylation within a CG sequence" EXACT [GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010425 name: DNA methylation on cytosine within a CNG sequence namespace: biological_process def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600] synonym: "cytosine methylation within a CNG sequence" EXACT [GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010426 name: DNA methylation on cytosine within a CHH sequence namespace: biological_process def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide." [GOC:dph, GOC:mah, GOC:tb, PMID:15861207, PMID:17239600] synonym: "cytosine methylation within a CHH sequence" EXACT [GOC:mah] synonym: "cytosine methylation within a CNN sequence" EXACT [GOC:dph, GOC:tb] synonym: "DNA methylation on cytosine within a CNN sequence" EXACT [GOC:mah] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010427 name: abscisic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with abscisic acid, plant hormones that regulate aspects of plant growth." [PMID:17347412] synonym: "ABA binding" RELATED [] synonym: "abscisate binding" RELATED [] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0010428 name: methyl-CpNpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0010429 name: methyl-CpNpN binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0010430 name: fatty acid omega-oxidation namespace: biological_process def: "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation." [MetaCyc:PWY-2724, PMID:16404574] xref: MetaCyc:PWY-2724 is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0010431 name: seed maturation namespace: biological_process def: "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination." [PMID:16096971] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010432 name: bract development namespace: biological_process def: "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:0048827 ! phyllome development [Term] id: GO:0010433 name: bract morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0010432 ! bract development [Term] id: GO:0010434 name: bract formation namespace: biological_process def: "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010433 ! bract morphogenesis [Term] id: GO:0010435 name: 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0." [PMID:16963437] synonym: "3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity" EXACT [MetaCyc:RXN-10695] synonym: "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity" EXACT [] synonym: "OPC-8:0 CoA ligase activity" EXACT [] xref: EC:6.2.1.- xref: MetaCyc:RXN-10695 is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0010436 name: carotenoid dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333] synonym: "carotenoid-cleaving dioxygenase" RELATED [] is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010437 name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333] is_a: GO:0010436 ! carotenoid dioxygenase activity [Term] id: GO:0010438 name: cellular response to sulfur starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur." [PMID:17420480] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010439 name: regulation of glucosinolate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [PMID:17420480] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process relationship: regulates GO:0019761 ! glucosinolate biosynthetic process [Term] id: GO:0010440 name: stomatal lineage progression namespace: biological_process def: "The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex." [GOC:expert_db, GOC:tb] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0010374 ! stomatal complex development [Term] id: GO:0010441 name: guard cell development namespace: biological_process def: "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0048468 ! cell development relationship: part_of GO:0010052 ! guard cell differentiation [Term] id: GO:0010442 name: guard cell morphogenesis namespace: biological_process def: "Generation and organization of the polarized cell that is capable of turgor driven movement." [GOC:expert_db, GOC:tb] synonym: "guard cell morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0010441 ! guard cell development [Term] id: GO:0010443 name: meristemoid mother cell division namespace: biological_process def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb] synonym: "meristemoid division" RELATED [] is_a: GO:0000911 ! cytokinesis by cell plate formation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010444 name: guard mother cell differentiation namespace: biological_process def: "The process in which a meristemoid acquires the specialized features of a guard mother cell." [GOC:expert_db, GOC:tb] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010445 name: nuclear dicing body namespace: cellular_component def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570] synonym: "D body" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0010446 name: response to alkalinity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7." [GOC:tb] synonym: "response to alkaline pH" EXACT [] synonym: "response to basic pH" EXACT [] is_a: GO:0009268 ! response to pH [Term] id: GO:0010447 name: response to acidity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7." [GOC:tb] synonym: "response to acidic pH" EXACT [] is_a: GO:0009268 ! response to pH [Term] id: GO:0010448 name: vegetative meristem growth namespace: biological_process def: "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia." [GOC:tb, ISBN:0849397928] is_a: GO:0035266 ! meristem growth relationship: part_of GO:0048367 ! shoot development [Term] id: GO:0010449 name: root meristem growth namespace: biological_process def: "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root." [GOC:tb] is_a: GO:0035266 ! meristem growth relationship: part_of GO:0048364 ! root development [Term] id: GO:0010450 name: inflorescence meristem growth namespace: biological_process def: "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035266 ! meristem growth relationship: part_of GO:0010229 ! inflorescence development [Term] id: GO:0010451 name: floral meristem growth namespace: biological_process def: "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035266 ! meristem growth relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010452 name: histone H3-K36 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 36 of the histone." [GOC:tb] synonym: "histone H3 K36 methylation" EXACT [GOC:tb] synonym: "histone H3K36me" EXACT [GOC:tb] synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0010453 name: regulation of cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010454 name: negative regulation of cell fate commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045596 ! negative regulation of cell differentiation relationship: negatively_regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010455 name: positive regulation of cell fate commitment namespace: biological_process def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045597 ! positive regulation of cell differentiation relationship: positively_regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010456 name: cell proliferation in dorsal spinal cord namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb] is_a: GO:0061351 ! neural precursor cell proliferation [Term] id: GO:0010457 name: centriole-centriole cohesion namespace: biological_process def: "The process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb] is_a: GO:0051297 ! centrosome organization [Term] id: GO:0010458 name: exit from mitosis namespace: biological_process def: "The cell cycle process where a cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000087 ! M phase of mitotic cell cycle [Term] id: GO:0010459 name: negative regulation of heart rate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0045822 ! negative regulation of heart contraction [Term] id: GO:0010460 name: positive regulation of heart rate namespace: biological_process def: "Any process that activates or increases the frequency or rate of heart contraction." [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0045823 ! positive regulation of heart contraction [Term] id: GO:0010461 name: light-activated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb] is_a: GO:0005216 ! ion channel activity [Term] id: GO:0010462 name: regulation of light-activated voltage-gated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity." [GOC:dph, GOC:tb] is_a: GO:0016061 ! regulation of light-activated channel activity is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel activity [Term] id: GO:0010463 name: mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0010464 name: regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0010465 name: nerve growth factor receptor activity namespace: molecular_function def: "Combining with nerve growth factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb] is_a: GO:0005030 ! neurotrophin receptor activity [Term] id: GO:0010466 name: negative regulation of peptidase activity namespace: biological_process def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] subset: gosubset_prok xref: Reactome:1252967 "Gene Expression" xref: Reactome:1279897 "Gene Expression" xref: Reactome:1298808 "Gene Expression" xref: Reactome:1326470 "Gene Expression" xref: Reactome:1352584 "Gene Expression" xref: Reactome:1372812 "Gene Expression" xref: Reactome:1392824 "Gene Expression" xref: Reactome:1417297 "Gene Expression" xref: Reactome:1450387 "Gene Expression" xref: Reactome:1470914 "Gene Expression" xref: Reactome:1482954 "Gene Expression" xref: Reactome:1496739 "Gene Expression" xref: Reactome:1514129 "Gene Expression" xref: Reactome:1520954 "Gene Expression" xref: Reactome:1526704 "Gene Expression" xref: Reactome:1532430 "Gene Expression" xref: Reactome:1535983 "Gene Expression" xref: Reactome:1538031 "Gene Expression" xref: Reactome:1539358 "Gene Expression" xref: Reactome:1540368 "Gene Expression" xref: Reactome:74160 "Gene Expression" xref: Wikipedia:Gene_expression is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] subset: gosubset_prok synonym: "regulation of gene product expression" RELATED [GOC:curators] synonym: "regulation of protein expression" NARROW [GOC:curators] xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0010467 ! gene expression [Term] id: GO:0010469 name: regulation of receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0010470 name: regulation of gastrulation namespace: biological_process def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0007369 ! gastrulation [Term] id: GO:0010471 name: GDP-galactose:mannose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + alpha-L-galactose-1-phosphate." [MetaCyc:RXN4FS-12, PMID:17485667] synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER] synonym: "GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-12] xref: MetaCyc:RXN4FS-12 is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0010472 name: GDP-galactose:glucose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-glucose 1-phosphate = alpha-L-galactose-1-phosphate + GDP-alpha-D-glucose." [MetaCyc:RXN4FS-13, PMID:17485667] synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER] synonym: "GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-13] xref: MetaCyc:RXN4FS-13 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010473 name: GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol." [PMID:17485667] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010474 name: glucose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose." [PMID:17462988] synonym: "GDP:glucose-1-phosphate guanyltransferase activity " EXACT [] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010475 name: galactose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose." [PMID:17462988] synonym: "GDP:galactose-1-phosphate guanyltransferase activity " EXACT [] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010476 name: gibberellin mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of gibberellin stimulus." [PMID:17521411] synonym: "gibberellin-mediated signalling" EXACT [GOC:mah] is_a: GO:0009755 ! hormone-mediated signaling pathway [Term] id: GO:0010477 name: response to sulfur dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [PMID:17425719] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010478 name: chlororespiration namespace: biological_process def: "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool." [GOC:mtg_electron_transport, GOC:tb, PMID:17573537] is_a: GO:0022904 ! respiratory electron transport chain [Term] id: GO:0010479 name: stele development namespace: biological_process def: "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds." [GOC:tb] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048364 ! root development [Term] id: GO:0010480 name: microsporocyte differentiation namespace: biological_process def: "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [CL:0000248 "Cell type ontology", PMID:16751349] synonym: "pollen mother cell differentiation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048653 ! anther development [Term] id: GO:0010481 name: epidermal cell division namespace: biological_process def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124] synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051301 ! cell division [Term] id: GO:0010482 name: regulation of epidermal cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124] synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051302 ! regulation of cell division relationship: regulates GO:0010481 ! epidermal cell division [Term] id: GO:0010483 name: pollen tube reception namespace: biological_process def: "Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells." [GOC:tb, PMID:17673660] is_a: GO:0051703 ! intraspecies interaction between organisms relationship: part_of GO:0009856 ! pollination [Term] id: GO:0010484 name: H3 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [EC:2.3.1.48] is_a: GO:0004402 ! histone acetyltransferase activity [Term] id: GO:0010485 name: H4 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48] is_a: GO:0004402 ! histone acetyltransferase activity [Term] id: GO:0010486 name: manganese:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518] synonym: "manganese:proton antiporter activity" EXACT [GOC:mah] is_a: GO:0005384 ! manganese ion transmembrane transporter activity is_a: GO:0051139 ! metal ion:hydrogen antiporter activity [Term] id: GO:0010487 name: thermospermine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+." [EC:2.5.1.79, MetaCyc:RXN-11190, PMID:17560575] xref: EC:2.5.1.79 xref: MetaCyc:RXN-11190 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0010488 name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273] is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0010489 name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829] is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0010490 name: UDP-4-keto-rhamnose-4-keto-reductase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0010491 name: UTP:arabinose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835] is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0010492 name: maintenance of shoot apical meristem identity namespace: biological_process def: "The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb, PMID:17461786] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010493 name: Lewis a epitope biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-1->4(Gal-beta-1->3)GlcNAc) characteristic of plant protein N-linked oligosaccharides." [PMID:17630273] synonym: "LE A biosynthetic process" RELATED [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0010494 name: stress granule namespace: cellular_component def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [PMID:17601829] xref: Wikipedia:Stress_granule is_a: GO:0035770 ! RNA granule [Term] id: GO:0010495 name: long-distance posttranscriptional gene silencing namespace: biological_process def: "A posttranscriptional gene silencing process in which the silencing signal originates in a tissue separate from the tissue in which the silencing takes place." [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412] synonym: "long-distance propagation of posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0010496 name: intercellular transport namespace: biological_process def: "The movement of substances between cells in a multicellular organism." [GOC:dhl] is_a: GO:0006810 ! transport is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0010497 name: plasmodesmata-mediated intercellular transport namespace: biological_process def: "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:17601829] synonym: "plasmodesma-mediated cell-to-cell transport" EXACT [] synonym: "plasmodesma-mediated intercellular transport" EXACT [] synonym: "plasmodesmata-mediated cell-to-cell transport" EXACT [] is_a: GO:0010496 ! intercellular transport [Term] id: GO:0010498 name: proteasomal protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] synonym: "proteasome-mediated protein catabolic process" EXACT [] synonym: "proteasome-mediated protein catabolism" EXACT [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0010499 name: proteasomal ubiquitin-independent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin." [GOC:tb] is_a: GO:0010498 ! proteasomal protein catabolic process [Term] id: GO:0010500 name: transmitting tissue development namespace: biological_process def: "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary." [PMID:17855426] is_a: GO:0048467 ! gynoecium development [Term] id: GO:0010501 name: RNA secondary structure unwinding namespace: biological_process def: "The process in which a secondary structure of RNA are broken or 'melted'." [PMID:17169986] synonym: "RNA duplex unwinding" EXACT [GOC:ecd] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0010503 name: negative regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010504 ! regulation of cell cycle arrest in response to nitrogen starvation is_a: GO:0010516 ! negative regulation of cellular response to nitrogen starvation is_a: GO:0071157 ! negative regulation of cell cycle arrest relationship: negatively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation [Term] id: GO:0010504 name: regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0071156 ! regulation of cell cycle arrest is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation [Term] id: GO:0010505 name: positive regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010504 ! regulation of cell cycle arrest in response to nitrogen starvation is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0071158 ! positive regulation of cell cycle arrest relationship: positively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation [Term] id: GO:0010506 name: regulation of autophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process relationship: regulates GO:0006914 ! autophagy [Term] id: GO:0010507 name: negative regulation of autophagy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031330 ! negative regulation of cellular catabolic process relationship: negatively_regulates GO:0006914 ! autophagy [Term] id: GO:0010508 name: positive regulation of autophagy namespace: biological_process def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031331 ! positive regulation of cellular catabolic process relationship: positively_regulates GO:0006914 ! autophagy [Term] id: GO:0010509 name: polyamine homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a polyamine." [GOC:dph, GOC:rph, GOC:tb, PMID:11161802, PMID:9761731] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010510 name: regulation of acetyl-CoA biosynthetic process from pyruvate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:tb] xref: Reactome:1253551 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:1280490 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:1327069 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:1353163 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:1373341 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:1393363 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:1417861 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:1450949 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:1483298 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:1532696 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:204174 "Regulation of pyruvate dehydrogenase (PDH) complex" is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process relationship: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate [Term] id: GO:0010511 name: regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0071071 ! regulation of phospholipid biosynthetic process relationship: regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010512 name: negative regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process relationship: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010513 name: positive regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process relationship: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010514 name: induction of conjugation with cellular fusion namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types." [GOC:dph, GOC:tb] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion [Term] id: GO:0010515 name: negative regulation of induction of conjugation with cellular fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion [Term] id: GO:0010516 name: negative regulation of cellular response to nitrogen starvation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress relationship: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation [Term] id: GO:0010517 name: regulation of phospholipase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0060191 ! regulation of lipase activity [Term] id: GO:0010518 name: positive regulation of phospholipase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010517 ! regulation of phospholipase activity is_a: GO:0060193 ! positive regulation of lipase activity [Term] id: GO:0010519 name: negative regulation of phospholipase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010517 ! regulation of phospholipase activity is_a: GO:0060192 ! negative regulation of lipase activity [Term] id: GO:0010520 name: regulation of reciprocal meiotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0060631 ! regulation of meiosis I relationship: regulates GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010521 name: telomerase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0010522 name: regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051924 ! regulation of calcium ion transport is_a: GO:2000021 ! regulation of ion homeostasis relationship: regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010523 name: negative regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051926 ! negative regulation of calcium ion transport relationship: negatively_regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010524 name: positive regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051928 ! positive regulation of calcium ion transport relationship: positively_regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010525 name: regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition relationship: regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010526 name: negative regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010525 ! regulation of transposition, RNA-mediated is_a: GO:0010529 ! negative regulation of transposition relationship: negatively_regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010527 name: positive regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010525 ! regulation of transposition, RNA-mediated is_a: GO:0010530 ! positive regulation of transposition relationship: positively_regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010528 name: regulation of transposition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0032196 ! transposition [Term] id: GO:0010529 name: negative regulation of transposition namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0032196 ! transposition [Term] id: GO:0010530 name: positive regulation of transposition namespace: biological_process def: "Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0032196 ! transposition [Term] id: GO:0010531 name: activation of JAK1 kinase activity namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] synonym: "activation of JAK1 protein" EXACT [GOC:dph, GOC:tb] synonym: "tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb] is_a: GO:0042976 ! activation of Janus kinase activity [Term] id: GO:0010532 name: regulation of activation of JAK1 kinase activity namespace: biological_process def: "Any process that modulates the frequency or rate of activation of JAK1 protein. The activation of JAK1 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] synonym: "regulation of activation of JAK1 protein" EXACT [GOC:dph, GOC:tb] synonym: "regulation of tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb] is_a: GO:0010533 ! regulation of activation of Janus kinase activity relationship: regulates GO:0010531 ! activation of JAK1 kinase activity [Term] id: GO:0010533 name: regulation of activation of Janus kinase activity namespace: biological_process def: "Any process that modulates the frequency or rate of activation of JAK protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:17190829, PMID:9135582] synonym: "regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] synonym: "regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] is_a: GO:0046425 ! regulation of JAK-STAT cascade is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation relationship: regulates GO:0042976 ! activation of Janus kinase activity [Term] id: GO:0010534 name: regulation of activation of JAK2 kinase activity namespace: biological_process def: "Any process that modulates the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] synonym: "regulation of activation of JAK2 protein" EXACT [GOC:dph, GOC:tb] synonym: "regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:dph, GOC:tb] is_a: GO:0010533 ! regulation of activation of Janus kinase activity relationship: regulates GO:0042977 ! activation of JAK2 kinase activity [Term] id: GO:0010535 name: positive regulation of activation of JAK2 kinase activity namespace: biological_process def: "Any process that increase the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] synonym: "positive regulation of activation of JAK2 protein" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:dph, GOC:tb] is_a: GO:0010534 ! regulation of activation of JAK2 kinase activity is_a: GO:0010536 ! positive regulation of activation of Janus kinase activity relationship: positively_regulates GO:0042977 ! activation of JAK2 kinase activity [Term] id: GO:0010536 name: positive regulation of activation of Janus kinase activity namespace: biological_process def: "Any process that increases the frequency or rate of activation of JAK protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] synonym: "positive regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] is_a: GO:0010533 ! regulation of activation of Janus kinase activity is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation relationship: positively_regulates GO:0042976 ! activation of Janus kinase activity [Term] id: GO:0010537 name: positive regulation of activation of JAK1 kinase activity namespace: biological_process def: "Any process that increases the frequency or rate of activation of JAK1 protein. The activation of JAK1 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] synonym: "positive regulation of activation of JAK1 protein" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb] is_a: GO:0010532 ! regulation of activation of JAK1 kinase activity is_a: GO:0010536 ! positive regulation of activation of Janus kinase activity relationship: positively_regulates GO:0010531 ! activation of JAK1 kinase activity [Term] id: GO:0010538 name: Hsp27 protein regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb, PMID:11546764] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'. is_obsolete: true replaced_by: GO:0051008 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010539 name: Hsp27 protein inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'. is_obsolete: true replaced_by: GO:0051008 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010540 name: basipetal auxin transport namespace: biological_process def: "The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] is_a: GO:0009926 ! auxin polar transport [Term] id: GO:0010541 name: acropetal auxin transport namespace: biological_process def: "The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] is_a: GO:0009926 ! auxin polar transport [Term] id: GO:0010542 name: nitrate efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane." [GOC:mah] is_a: GO:0015113 ! nitrite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0010543 name: regulation of platelet activation namespace: biological_process def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050865 ! regulation of cell activation relationship: regulates GO:0030168 ! platelet activation [Term] id: GO:0010544 name: negative regulation of platelet activation namespace: biological_process def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:0050866 ! negative regulation of cell activation relationship: negatively_regulates GO:0030168 ! platelet activation [Term] id: GO:0010545 name: Hsp90 protein regulator activity namespace: molecular_function def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsp90." [GOC:dph, GOC:tb, PMID:11146632] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'. is_obsolete: true replaced_by: GO:0051879 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010546 name: Hsp90 protein inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp90 molecular chaperone." [GOC:dph, GOC:tb, PMID:11146632] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'. is_obsolete: true replaced_by: GO:0051879 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010547 name: thylakoid membrane disassembly namespace: biological_process def: "The controlled breakdown of the thylakoid membrane in the context of a normal process." [GOC:dph, GOC:tb, PMID:17416733] synonym: "thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010027 ! thylakoid membrane organization is_a: GO:0030397 ! membrane disassembly [Term] id: GO:0010548 name: regulation of thylakoid membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly." [GOC:dph, GOC:tb, PMID:17416733] synonym: "regulation of thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010549 ! regulation of membrane disassembly is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0010547 ! thylakoid membrane disassembly [Term] id: GO:0010549 name: regulation of membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0030397 ! membrane disassembly [Term] id: GO:0010550 name: regulation of PSII associated light-harvesting complex II catabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:dph, GOC:tb] synonym: "regulation of LHCII catabolism" EXACT [GOC:dph, GOC:tb, PMID:17416733] synonym: "regulation of LHCII degradation" EXACT [PMID:17416733] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process relationship: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process [Term] id: GO:0010554 name: neurotransmitter secretory pathway namespace: biological_process def: "A regulated secretory pathway in which neurotransmitters are initially stored in secretory vesicles for later release." [GOC:dph, GOC:tb] is_a: GO:0045055 ! regulated secretory pathway relationship: part_of GO:0007269 ! neurotransmitter secretion [Term] id: GO:0010555 name: response to mannitol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [PMID:17999646] is_a: GO:0009743 ! response to carbohydrate stimulus [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010559 name: regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010560 name: positive regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010561 name: negative regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010562 name: positive regulation of phosphorus metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process relationship: positively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010563 name: negative regulation of phosphorus metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle relationship: regulates GO:0022402 ! cell cycle process [Term] id: GO:0010565 name: regulation of cellular ketone metabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0010566 name: regulation of ketone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0042181 ! ketone biosynthetic process [Term] id: GO:0010567 name: regulation of ketone catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process relationship: regulates GO:0042182 ! ketone catabolic process [Term] id: GO:0010568 name: regulation of budding cell apical bud growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding." [GOC:dph, GOC:jp, GOC:tb, PMID:17417630] is_a: GO:0007116 ! regulation of cell budding is_a: GO:0040008 ! regulation of growth relationship: regulates GO:0007118 ! budding cell apical bud growth [Term] id: GO:0010569 name: regulation of double-strand break repair via homologous recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0006282 ! regulation of DNA repair relationship: regulates GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0010570 name: regulation of filamentous growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0040008 ! regulation of growth relationship: regulates GO:0030447 ! filamentous growth [Term] id: GO:0010571 name: positive regulation of DNA replication involved in S phase namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA replication that contributes to the progression through S phase of the cell cycle." [GOC:dph, GOC:jp, GOC:tb] synonym: "positive regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of DNA replication involved in S-phase" EXACT [] is_a: GO:0033262 ! regulation of DNA replication involved in S phase is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication relationship: positively_regulates GO:0033260 ! DNA replication involved in S phase [Term] id: GO:0010572 name: positive regulation of platelet activation namespace: biological_process def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0050867 ! positive regulation of cell activation relationship: positively_regulates GO:0030168 ! platelet activation [Term] id: GO:0010573 name: vascular endothelial growth factor production namespace: biological_process def: "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rl] synonym: "VEGF production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0010574 name: regulation of vascular endothelial growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:rl] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0010573 ! vascular endothelial growth factor production [Term] id: GO:0010575 name: positive regulation vascular endothelial growth factor production namespace: biological_process def: "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:BHF, GOC:rl] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0010574 ! regulation of vascular endothelial growth factor production relationship: positively_regulates GO:0010573 ! vascular endothelial growth factor production [Term] id: GO:0010576 name: metalloenzyme regulator activity namespace: molecular_function def: "Modulates the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0010577 name: metalloenzyme activator activity namespace: molecular_function def: "Increases the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:dph, GOC:tb] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0010576 ! metalloenzyme regulator activity [Term] id: GO:0010578 name: regulation of adenylate cyclase activity involved in G-protein signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb] synonym: "regulation of adenylate cyclase activity involved in G-protein signalling" EXACT [GOC:mah] is_a: GO:0045761 ! regulation of adenylate cyclase activity relationship: part_of GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger [Term] id: GO:0010579 name: positive regulation of adenylate cyclase activity by G-protein signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of adenylate cyclase activity that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb] synonym: "positive regulation of adenylate cyclase activity by G-protein signalling pathway" EXACT [GOC:mah] is_a: GO:0010578 ! regulation of adenylate cyclase activity involved in G-protein signaling pathway is_a: GO:0045762 ! positive regulation of adenylate cyclase activity [Term] id: GO:0010581 name: regulation of starch biosynthetic process namespace: biological_process def: "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch." [GOC:tb] is_a: GO:0010962 ! regulation of glucan biosynthetic process relationship: regulates GO:0019252 ! starch biosynthetic process [Term] id: GO:0010582 name: floral meristem determinacy namespace: biological_process def: "The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [PMID:18441215] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010022 ! meristem determinacy relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010583 name: response to cyclopentenone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [PMID:18334669] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0010584 name: pollen exine formation namespace: biological_process def: "The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine." [GOC:dhl] is_a: GO:0010208 ! pollen wall assembly [Term] id: GO:0010585 name: glutamine secretion namespace: biological_process def: "The controlled release of glutamine by a cell, a group of cells, or a tissue." [PMID:15208395] is_a: GO:0006868 ! glutamine transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0010586 name: miRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] synonym: "microRNA metabolic process" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0010587 name: miRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] synonym: "microRNA catabolic process" EXACT [] is_a: GO:0010586 ! miRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0010588 name: cotyledon vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants." [PMID:10559439] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0010589 name: leaf proximal/distal pattern formation namespace: biological_process def: "The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis." [PMID:18398054] is_a: GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0010590 name: regulation of cytokinetic cell separation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the process of physically separating progeny cells contributing to cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:dph, GOC:tb] synonym: "regulation of cell separation during cytokinesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0032954 ! regulation of cytokinetic process relationship: regulates GO:0000920 ! cytokinetic cell separation [Term] id: GO:0010591 name: regulation of lamellipodium assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] synonym: "regulation of lamellipodium biogenesis" RELATED [GOC:mah] is_a: GO:0060491 ! regulation of cell projection assembly relationship: regulates GO:0030032 ! lamellipodium assembly [Term] id: GO:0010592 name: positive regulation of lamellipodium assembly namespace: biological_process def: "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] synonym: "positive regulation of lamellipodium biogenesis" RELATED [GOC:mah] is_a: GO:0010591 ! regulation of lamellipodium assembly is_a: GO:0031346 ! positive regulation of cell projection organization relationship: positively_regulates GO:0030032 ! lamellipodium assembly [Term] id: GO:0010593 name: negative regulation of lamellipodium assembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] synonym: "negative regulation of lamellipodium biogenesis" RELATED [GOC:mah] is_a: GO:0010591 ! regulation of lamellipodium assembly is_a: GO:0031345 ! negative regulation of cell projection organization relationship: negatively_regulates GO:0030032 ! lamellipodium assembly [Term] id: GO:0010594 name: regulation of endothelial cell migration namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0043542 ! endothelial cell migration [Term] id: GO:0010595 name: positive regulation of endothelial cell migration namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0030335 ! positive regulation of cell migration relationship: positively_regulates GO:0043542 ! endothelial cell migration [Term] id: GO:0010596 name: negative regulation of endothelial cell migration namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0030336 ! negative regulation of cell migration relationship: negatively_regulates GO:0043542 ! endothelial cell migration [Term] id: GO:0010597 name: green leaf volatile biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid." [PMID:17163881] is_a: GO:0019372 ! lipoxygenase pathway [Term] id: GO:0010598 name: NAD(P)H dehydrogenase complex (plastoquinone) namespace: cellular_component def: "Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool." [PMID:15608332] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part is_a: GO:0044425 ! membrane part [Term] id: GO:0010599 name: production of lsiRNA involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions." [PMID:18003861] synonym: "RNA interference, production of lsiRNA" EXACT [GOC:mah] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0010600 name: regulation of auxin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0090354 ! regulation of auxin metabolic process relationship: regulates GO:0009851 ! auxin biosynthetic process [Term] id: GO:0010601 name: positive regulation of auxin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] is_a: GO:0010600 ! regulation of auxin biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0090355 ! positive regulation of auxin metabolic process relationship: positively_regulates GO:0009851 ! auxin biosynthetic process [Term] id: GO:0010602 name: regulation of 1-aminocyclopropane-1-carboxylate metabolic process namespace: biological_process def: "Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [PMID:18055613] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process [Term] id: GO:0010603 name: regulation of cytoplasmic mRNA processing body assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0033962 ! cytoplasmic mRNA processing body assembly [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: positively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010606 name: positive regulation of cytoplasmic mRNA processing body assembly namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly [Term] id: GO:0010607 name: negative regulation of cytoplasmic mRNA processing body assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly [Term] id: GO:0010608 name: posttranscriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0010609 name: posttranscriptional regulation of gene expression by mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell." [GOC:dph, GOC:tb] synonym: "posttranscriptional regulation of gene expression by mRNA localisation" EXACT [GOC:mah] is_a: GO:0008298 ! intracellular mRNA localization is_a: GO:0010608 ! posttranscriptional regulation of gene expression [Term] id: GO:0010610 name: regulation of mRNA stability involved in response to stress namespace: biological_process def: "Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance." [GOC:dph, GOC:tb] is_a: GO:0043488 ! regulation of mRNA stability relationship: part_of GO:0033554 ! cellular response to stress [Term] id: GO:0010611 name: regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0003300 ! cardiac muscle hypertrophy [Term] id: GO:0010612 name: regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0010613 name: positive regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014742 ! positive regulation of muscle hypertrophy relationship: positively_regulates GO:0003300 ! cardiac muscle hypertrophy [Term] id: GO:0010614 name: negative regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014741 ! negative regulation of muscle hypertrophy relationship: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy [Term] id: GO:0010615 name: positive regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014744 ! positive regulation of muscle adaptation relationship: positively_regulates GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0010616 name: negative regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014745 ! negative regulation of muscle adaptation relationship: negatively_regulates GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0010617 name: circadian regulation of calcium ion oscillation namespace: biological_process def: "Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours." [PMID:17982000] synonym: "circadian regulation of [Ca2+]cyt oscillation" RELATED [] synonym: "circadian regulation of Ca2+ oscillation" RELATED [] synonym: "circadian regulation of cytosolic calcium ion homeostasis" EXACT [GOC:dph, GOC:tb] synonym: "circadian regulation of cytosolic free calcium ion oscillation" RELATED [] is_a: GO:0007623 ! circadian rhythm is_a: GO:0051480 ! cytosolic calcium ion homeostasis [Term] id: GO:0010618 name: aerenchyma formation namespace: biological_process def: "The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts." [PMID:18055613, PO:0005702] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0010619 name: activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway namespace: biological_process def: "Any glucose-triggered process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb] synonym: "activation of adenylate cyclase activity by glucose involved in G-protein signaling" EXACT [GOC:dph, GOC:tb] synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway" EXACT [GOC:mah] is_a: GO:0007189 ! activation of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0010255 ! glucose mediated signaling pathway [Term] id: GO:0010620 name: negative regulation of transcription by transcription factor catabolism namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a transcription factor." [GOC:dph, GOC:tb] is_a: GO:0044257 ! cellular protein catabolic process is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0010621 name: negative regulation of transcription by transcription factor localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph, GOC:tb] synonym: "negative regulation of transcription by transcription factor localisation" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0010622 name: specification of ovule identity namespace: biological_process def: "The regionalization process in which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0048482 ! ovule morphogenesis [Term] id: GO:0010623 name: developmental programmed cell death namespace: biological_process def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb] is_a: GO:0012501 ! programmed cell death is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0048468 ! cell development [Term] id: GO:0010624 name: regulation of Schwann cell proliferation namespace: biological_process def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0060251 ! regulation of glial cell proliferation relationship: regulates GO:0014010 ! Schwann cell proliferation [Term] id: GO:0010625 name: positive regulation of Schwann cell proliferation namespace: biological_process def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060252 ! positive regulation of glial cell proliferation relationship: positively_regulates GO:0014010 ! Schwann cell proliferation [Term] id: GO:0010626 name: negative regulation of Schwann cell proliferation namespace: biological_process def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060253 ! negative regulation of glial cell proliferation relationship: negatively_regulates GO:0014010 ! Schwann cell proliferation [Term] id: GO:0010627 name: regulation of intracellular protein kinase cascade namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010604 ! positive regulation of macromolecule metabolic process relationship: positively_regulates GO:0010467 ! gene expression [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010605 ! negative regulation of macromolecule metabolic process relationship: negatively_regulates GO:0010467 ! gene expression [Term] id: GO:0010630 name: regulation of transcription, start site selection namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template." [GOC:dph, GOC:tb] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Term] id: GO:0010631 name: epithelial cell migration namespace: biological_process def: "The orderly movement of epithelial cells from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001667 ! ameboidal cell migration relationship: part_of GO:0090132 ! epithelium migration [Term] id: GO:0010632 name: regulation of epithelial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0010631 ! epithelial cell migration [Term] id: GO:0010633 name: negative regulation of epithelial cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030336 ! negative regulation of cell migration relationship: negatively_regulates GO:0010631 ! epithelial cell migration [Term] id: GO:0010634 name: positive regulation of epithelial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030335 ! positive regulation of cell migration relationship: positively_regulates GO:0010631 ! epithelial cell migration [Term] id: GO:0010635 name: regulation of mitochondrial fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0022603 ! regulation of anatomical structure morphogenesis relationship: regulates GO:0008053 ! mitochondrial fusion [Term] id: GO:0010636 name: positive regulation of mitochondrial fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0008053 ! mitochondrial fusion [Term] id: GO:0010637 name: negative regulation of mitochondrial fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0008053 ! mitochondrial fusion [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010640 name: regulation of platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] synonym: "regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0010641 name: positive regulation of platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway relationship: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0010642 name: negative regulation of platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway relationship: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0010643 name: cell communication by chemical coupling namespace: biological_process def: "The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0007154 ! cell communication [Term] id: GO:0010644 name: cell communication by electrical coupling namespace: biological_process def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0007154 ! cell communication [Term] id: GO:0010645 name: regulation of cell communication by chemical coupling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010646 ! regulation of cell communication relationship: regulates GO:0010643 ! cell communication by chemical coupling [Term] id: GO:0010646 name: regulation of cell communication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007154 ! cell communication [Term] id: GO:0010647 name: positive regulation of cell communication namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0007154 ! cell communication [Term] id: GO:0010648 name: negative regulation of cell communication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0007154 ! cell communication [Term] id: GO:0010649 name: regulation of cell communication by electrical coupling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010646 ! regulation of cell communication relationship: regulates GO:0010644 ! cell communication by electrical coupling [Term] id: GO:0010650 name: positive regulation of cell communication by electrical coupling namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0010649 ! regulation of cell communication by electrical coupling relationship: positively_regulates GO:0010644 ! cell communication by electrical coupling [Term] id: GO:0010651 name: negative regulation of cell communication by electrical coupling namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0010649 ! regulation of cell communication by electrical coupling relationship: negatively_regulates GO:0010644 ! cell communication by electrical coupling [Term] id: GO:0010652 name: positive regulation of cell communication by chemical coupling namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010645 ! regulation of cell communication by chemical coupling is_a: GO:0010647 ! positive regulation of cell communication relationship: positively_regulates GO:0010643 ! cell communication by chemical coupling [Term] id: GO:0010653 name: negative regulation of cell communication by chemical coupling namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010645 ! regulation of cell communication by chemical coupling is_a: GO:0010648 ! negative regulation of cell communication relationship: negatively_regulates GO:0010643 ! cell communication by chemical coupling [Term] id: GO:0010654 name: apical cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote." [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0045165 ! cell fate commitment is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010656 name: negative regulation of muscle cell apoptosis namespace: biological_process def: "Any process that decreases the rate or frequency of muscle cell apoptosis. Muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:tb] is_a: GO:0010660 ! regulation of muscle cell apoptosis is_a: GO:0043066 ! negative regulation of apoptosis relationship: negatively_regulates GO:0010657 ! muscle cell apoptosis [Term] id: GO:0010657 name: muscle cell apoptosis namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [GOC:dph, GOC:tb] is_a: GO:0006915 ! apoptosis [Term] id: GO:0010658 name: striated muscle cell apoptosis namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [GOC:dph, GOC:tb] is_a: GO:0010657 ! muscle cell apoptosis [Term] id: GO:0010659 name: cardiac muscle cell apoptosis namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:dph, GOC:tb] is_a: GO:0010658 ! striated muscle cell apoptosis [Term] id: GO:0010660 name: regulation of muscle cell apoptosis namespace: biological_process def: "Any process that modulates the rate or frequency of muscle cell apoptosis. Muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:tb] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0010657 ! muscle cell apoptosis [Term] id: GO:0010661 name: positive regulation of muscle cell apoptosis namespace: biological_process def: "Any process that increases the rate or frequency of muscle cell apoptosis. Muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:tb] is_a: GO:0010660 ! regulation of muscle cell apoptosis is_a: GO:0043065 ! positive regulation of apoptosis relationship: positively_regulates GO:0010657 ! muscle cell apoptosis [Term] id: GO:0010662 name: regulation of striated muscle cell apoptosis namespace: biological_process def: "Any process that modulates the rate or extent of striated muscle cell apoptosis. Striated muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:tb] is_a: GO:0010660 ! regulation of muscle cell apoptosis relationship: regulates GO:0010658 ! striated muscle cell apoptosis [Term] id: GO:0010663 name: positive regulation of striated muscle cell apoptosis namespace: biological_process def: "Any process that increases the rate or extent of striated muscle cell apoptosis. Striated muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:tb] is_a: GO:0010661 ! positive regulation of muscle cell apoptosis is_a: GO:0010662 ! regulation of striated muscle cell apoptosis relationship: positively_regulates GO:0010658 ! striated muscle cell apoptosis [Term] id: GO:0010664 name: negative regulation of striated muscle cell apoptosis namespace: biological_process def: "Any process that increases the rate or extent of striated muscle cell apoptosis. Striated muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "down regulation of striated muscle cell apoptosis " EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of striated muscle cell apoptosis " NARROW [GOC:dph, GOC:rl, GOC:tb] is_a: GO:0010656 ! negative regulation of muscle cell apoptosis is_a: GO:0010662 ! regulation of striated muscle cell apoptosis relationship: negatively_regulates GO:0010658 ! striated muscle cell apoptosis [Term] id: GO:0010665 name: regulation of cardiac muscle cell apoptosis namespace: biological_process def: "Any process that modulates the rate or extent of cardiac cell apoptosis. Cardiac cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:tb] is_a: GO:0010662 ! regulation of striated muscle cell apoptosis relationship: regulates GO:0010659 ! cardiac muscle cell apoptosis [Term] id: GO:0010666 name: positive regulation of cardiac muscle cell apoptosis namespace: biological_process def: "Any process that increases the rate or extent of cardiac cell apoptosis. Cardiac cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:tb] is_a: GO:0010663 ! positive regulation of striated muscle cell apoptosis is_a: GO:0010665 ! regulation of cardiac muscle cell apoptosis relationship: positively_regulates GO:0010659 ! cardiac muscle cell apoptosis [Term] id: GO:0010667 name: negative regulation of cardiac muscle cell apoptosis namespace: biological_process def: "Any process that decreases the rate or extent of cardiac cell apoptosis. Cardiac cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of cardiac muscle cell apoptosis " NARROW [GOC:dph, GOC:rl, GOC:tb] is_a: GO:0010664 ! negative regulation of striated muscle cell apoptosis is_a: GO:0010665 ! regulation of cardiac muscle cell apoptosis relationship: negatively_regulates GO:0010659 ! cardiac muscle cell apoptosis [Term] id: GO:0010668 name: ectodermal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0010669 name: epithelial structure maintenance namespace: biological_process def: "A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb] is_a: GO:0001894 ! tissue homeostasis [Term] id: GO:0010670 name: positive regulation of oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. is_obsolete: true consider: GO:2000376 consider: GO:2000379 [Term] id: GO:0010671 name: negative regulation of oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. is_obsolete: true consider: GO:2000375 consider: GO:2000378 [Term] id: GO:0010672 name: regulation of transcription from RNA polymerase II promoter during meiosis namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis." [GOC:dph, GOC:tb] synonym: "regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0051037 ! regulation of transcription during meiosis [Term] id: GO:0010673 name: positive regulation of transcription from RNA polymerase II promoter during meiosis namespace: biological_process def: "A cell cycle process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis." [GOC:dph, GOC:tb] synonym: "positive regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter during meiosis is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0051039 ! positive regulation of transcription during meiosis [Term] id: GO:0010674 name: negative regulation of transcription from RNA polymerase II promoter during meiosis namespace: biological_process def: "A cell cycle process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis." [GOC:dph, GOC:tb] synonym: "negative regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter during meiosis is_a: GO:0051038 ! negative regulation of transcription during meiosis [Term] id: GO:0010675 name: regulation of cellular carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010676 name: positive regulation of cellular carbohydrate metabolic process namespace: biological_process def: "Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process relationship: positively_regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010677 name: negative regulation of cellular carbohydrate metabolic process namespace: biological_process def: "Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process relationship: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010678 name: negative regulation of cellular carbohydrate metabolic process by repression of transcription namespace: biological_process def: "Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription." [GOC:dph, GOC:tb] synonym: "negative regulation of cellular carbohydrate metabolic process by transcriptional repression" EXACT [GOC:dph, GOC:tb] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0010679 name: cinnamic acid biosynthetic process involved in salicylic acid metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of salicylic acid." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process relationship: part_of GO:0009696 ! salicylic acid metabolic process [Term] id: GO:0010680 name: cinnamic acid biosynthetic process involved in coumarin metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of coumarin." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process relationship: part_of GO:0009804 ! coumarin metabolic process [Term] id: GO:0010681 name: cinnamic biosynthetic process involved in stilbene metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of stilbene." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process relationship: part_of GO:0009810 ! stilbene metabolic process [Term] id: GO:0010682 name: cinnamic acid biosynthetic process involved in flavonoid metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process relationship: part_of GO:0009812 ! flavonoid metabolic process [Term] id: GO:0010683 name: tricyclic triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] synonym: "tricyclic triterpenoid metabolism" EXACT [GOC:tair_curators] is_a: GO:0006722 ! triterpenoid metabolic process [Term] id: GO:0010684 name: tricyclic triterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] synonym: "tricyclic triterpenoid catabolism" EXACT [GOC:tair_curators] is_a: GO:0010683 ! tricyclic triterpenoid metabolic process is_a: GO:0016105 ! triterpenoid catabolic process [Term] id: GO:0010685 name: tetracyclic triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] synonym: "tetracyclic triterpenoid metabolism" EXACT [GOC:tair_curators] is_a: GO:0006722 ! triterpenoid metabolic process [Term] id: GO:0010686 name: tetracyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] synonym: "tetracyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process is_a: GO:0016104 ! triterpenoid biosynthetic process [Term] id: GO:0010687 name: site selection involved in cell cycle cytokinesis namespace: biological_process def: "The process of marking the place where cytokinesis will occur in the context of cell cycle progression." [GOC:dph, GOC:tb] is_a: GO:0007105 ! cytokinesis, site selection relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0010688 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:dph, GOC:tb] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0060962 ! regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Term] id: GO:0010689 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus." [GOC:dph, GOC:tb] is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0010690 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis." [GOC:dph, GOC:tb] is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0010691 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:dph, GOC:tb] is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter is_a: GO:0031669 ! cellular response to nutrient levels [Term] id: GO:0010692 name: regulation of alkaline phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity [Term] id: GO:0010693 name: negative regulation of alkaline phosphatase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010692 ! regulation of alkaline phosphatase activity is_a: GO:0010923 ! negative regulation of phosphatase activity [Term] id: GO:0010694 name: positive regulation of alkaline phosphatase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] is_a: GO:0010692 ! regulation of alkaline phosphatase activity is_a: GO:0010922 ! positive regulation of phosphatase activity [Term] id: GO:0010695 name: regulation of spindle pole body separation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] synonym: "regulation of SPB separation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: regulates GO:0000073 ! spindle pole body separation [Term] id: GO:0010696 name: positive regulation of spindle pole body separation namespace: biological_process def: "Any process that increases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] synonym: "positive regulation of SPB separation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010695 ! regulation of spindle pole body separation is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0000073 ! spindle pole body separation [Term] id: GO:0010697 name: negative regulation of spindle pole body separation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] synonym: "negative regulation of SPB separation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010695 ! regulation of spindle pole body separation is_a: GO:0010948 ! negative regulation of cell cycle process relationship: negatively_regulates GO:0000073 ! spindle pole body separation [Term] id: GO:0010698 name: acetyltransferase activator activity namespace: molecular_function def: "Increases the activity of an aceyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [GOC:dph, GOC:jp, GOC:tb, PMID:18690240] synonym: "acetyltransferase stimulator activity" EXACT [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0010699 name: cell-cell signaling involved in quorum sensing namespace: biological_process def: "The cell-cell signaling process in which single-celled organisms monitor population density by detecting the concentration of small diffusible signal molecules." [GOC:dph, GOC:tb] synonym: "cell-cell signalling involved in quorum sensing" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0009372 ! quorum sensing [Term] id: GO:0010700 name: negative regulation of norepinephrine secretion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion relationship: negatively_regulates GO:0048243 ! norepinephrine secretion [Term] id: GO:0010701 name: positive regulation of norepinephrine secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion relationship: positively_regulates GO:0048243 ! norepinephrine secretion [Term] id: GO:0010702 name: regulation of histolysis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0007559 ! histolysis [Term] id: GO:0010703 name: negative regulation of histolysis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "down regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of histolysis" NARROW [GOC:dph, GOC:rl, GOC:tb] is_a: GO:0010702 ! regulation of histolysis is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0007559 ! histolysis [Term] id: GO:0010704 name: meiotic DNA double-strand break processing involved in meiotic gene conversion namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000706 ! meiotic DNA double-strand break processing relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010705 name: meiotic DNA double-strand break processing involved in reciprocal meiotic recombination namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000706 ! meiotic DNA double-strand break processing relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010706 name: biosynthesis of lactosylceramide precursor to ganglioside namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group as a precursor of gangliosides." [GOC:dph, GOC:tb] synonym: "lactosylceramide biosynthesis leading to ganglioside" RELATED [GOC:dph, GOC:tb] synonym: "lactosylceramide biosynthetic process leading to ganglioside" RELATED [GOC:dph, GOC:tb] is_a: GO:0001572 ! lactosylceramide biosynthetic process is_a: GO:0001574 ! ganglioside biosynthetic process [Term] id: GO:0010707 name: biosynthesis of lactosylceramide precursor to globoside namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group as a precursor of globosides." [GOC:dph, GOC:tb] synonym: "lactosylceramide biosynthesis leading to globoside" RELATED [GOC:dph, GOC:tb] synonym: "lactosylceramide biosynthetic process leading to globoside" RELATED [GOC:dph, GOC:tb] is_a: GO:0001572 ! lactosylceramide biosynthetic process is_a: GO:0001576 ! globoside biosynthetic process [Term] id: GO:0010708 name: heteroduplex formation involved in gene conversion at mating-type locus namespace: biological_process def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the conversion of the mating-type locus from one allele to another." [GOC:dph, GOC:tb] is_a: GO:0030491 ! heteroduplex formation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0010709 name: heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing namespace: biological_process def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences." [GOC:dph, GOC:tb] is_a: GO:0030491 ! heteroduplex formation relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0010710 name: regulation of collagen catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010712 ! regulation of collagen metabolic process relationship: regulates GO:0030574 ! collagen catabolic process [Term] id: GO:0010711 name: negative regulation of collagen catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010713 ! negative regulation of collagen metabolic process relationship: negatively_regulates GO:0030574 ! collagen catabolic process [Term] id: GO:0010712 name: regulation of collagen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0044246 ! regulation of multicellular organismal metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0032963 ! collagen metabolic process [Term] id: GO:0010713 name: negative regulation of collagen metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process is_a: GO:0044252 ! negative regulation of multicellular organismal metabolic process relationship: negatively_regulates GO:0032963 ! collagen metabolic process [Term] id: GO:0010714 name: positive regulation of collagen metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process relationship: positively_regulates GO:0032963 ! collagen metabolic process [Term] id: GO:0010715 name: regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0022617 ! extracellular matrix disassembly [Term] id: GO:0010716 name: negative regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0022617 ! extracellular matrix disassembly [Term] id: GO:0010717 name: regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0010718 name: positive regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation relationship: positively_regulates GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0010719 name: negative regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation relationship: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0010720 name: positive regulation of cell development namespace: biological_process def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development relationship: positively_regulates GO:0048468 ! cell development [Term] id: GO:0010721 name: negative regulation of cell development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development relationship: negatively_regulates GO:0048468 ! cell development [Term] id: GO:0010722 name: regulation of ferrochelatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [GOC:dph, GOC:tb] is_a: GO:0051339 ! regulation of lyase activity [Term] id: GO:0010723 name: positive regulation of transcription from RNA polymerase II promoter in response to iron namespace: biological_process def: "Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:dph, GOC:tb] is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter [Term] id: GO:0010724 name: regulation of definitive erythrocyte differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of definitive erythropoiesis" EXACT [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of definitive RBC differentiation" EXACT [CL:0000232] synonym: "regulation of definitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045646 ! regulation of erythrocyte differentiation relationship: regulates GO:0060318 ! definitive erythrocyte differentiation [Term] id: GO:0010725 name: regulation of primitive erythrocyte differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of primitive erythropoeisis" EXACT [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of primitive RBC differentiation" EXACT [CL:0000232] synonym: "regulation of primitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045646 ! regulation of erythrocyte differentiation is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0060319 ! primitive erythrocyte differentiation [Term] id: GO:0010726 name: positive regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process relationship: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010727 name: negative regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process relationship: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010728 name: regulation of hydrogen peroxide biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] synonym: "regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0050665 ! hydrogen peroxide biosynthetic process [Term] id: GO:0010729 name: positive regulation of hydrogen peroxide biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process relationship: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process [Term] id: GO:0010730 name: negative regulation of hydrogen peroxide biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process relationship: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process [Term] id: GO:0010731 name: protein glutathionylation namespace: biological_process def: "The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0010732 name: regulation of protein glutathionylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "regulation of protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0010731 ! protein glutathionylation [Term] id: GO:0010733 name: positive regulation of protein glutathionylation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "positive regulation of protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0010732 ! regulation of protein glutathionylation is_a: GO:0031401 ! positive regulation of protein modification process relationship: positively_regulates GO:0010731 ! protein glutathionylation [Term] id: GO:0010734 name: negative regulation of protein glutathionylation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0010732 ! regulation of protein glutathionylation is_a: GO:0031400 ! negative regulation of protein modification process relationship: negatively_regulates GO:0010731 ! protein glutathionylation [Term] id: GO:0010735 name: positive regulation of transcription via serum response element binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter [Term] id: GO:0010736 name: serum response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0010737 name: protein kinase A signaling cascade namespace: biological_process def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] synonym: "PKA signaling cascade" EXACT [GOC:dph, GOC:tb] synonym: "protein kinase A signalling cascade" EXACT [GOC:mah] is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0010738 name: regulation of protein kinase A signaling cascade namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the protein kinase A signaling cascade. The PKA signaling cascade is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of PKA signaling cascade" EXACT [GOC:dph, GOC:tb] synonym: "regulation of protein kinase A signalling cascade" EXACT [GOC:mah] is_a: GO:0010627 ! regulation of intracellular protein kinase cascade relationship: regulates GO:0010737 ! protein kinase A signaling cascade [Term] id: GO:0010739 name: positive regulation of protein kinase A signaling cascade namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the protein kinase A signaling cascade. The PKA signaling cascade is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of PKA signaling cascade" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of protein kinase A signalling cascade" EXACT [GOC:mah] is_a: GO:0010738 ! regulation of protein kinase A signaling cascade is_a: GO:0010740 ! positive regulation of intracellular protein kinase cascade relationship: positively_regulates GO:0010737 ! protein kinase A signaling cascade [Term] id: GO:0010740 name: positive regulation of intracellular protein kinase cascade namespace: biological_process def: "Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010627 ! regulation of intracellular protein kinase cascade relationship: positively_regulates GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0010741 name: negative regulation of intracellular protein kinase cascade namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010627 ! regulation of intracellular protein kinase cascade relationship: negatively_regulates GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0010742 name: macrophage derived foam cell differentiation namespace: biological_process def: "The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0090077 ! foam cell differentiation [Term] id: GO:0010743 name: regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0010742 ! macrophage derived foam cell differentiation [Term] id: GO:0010744 name: positive regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation relationship: positively_regulates GO:0010742 ! macrophage derived foam cell differentiation [Term] id: GO:0010745 name: negative regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation relationship: negatively_regulates GO:0010742 ! macrophage derived foam cell differentiation [Term] id: GO:0010746 name: regulation of plasma membrane long-chain fatty acid transport namespace: biological_process def: "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:2000191 ! regulation of fatty acid transport relationship: regulates GO:0015911 ! plasma membrane long-chain fatty acid transport [Term] id: GO:0010747 name: positive regulation of plasma membrane long-chain fatty acid transport namespace: biological_process def: "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010746 ! regulation of plasma membrane long-chain fatty acid transport is_a: GO:2000193 ! positive regulation of fatty acid transport relationship: positively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport [Term] id: GO:0010748 name: negative regulation of plasma membrane long-chain fatty acid transport namespace: biological_process def: "Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010746 ! regulation of plasma membrane long-chain fatty acid transport is_a: GO:2000192 ! negative regulation of fatty acid transport relationship: negatively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport [Term] id: GO:0010749 name: regulation of nitric oxide mediated signal transduction namespace: biological_process def: "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of nitric oxide-mediated signal transduction" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007263 ! nitric oxide mediated signal transduction [Term] id: GO:0010750 name: positive regulation of nitric oxide mediated signal transduction namespace: biological_process def: "Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of nitric oxide-mediated signal transduction" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction relationship: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction [Term] id: GO:0010751 name: negative regulation of nitric oxide mediated signal transduction namespace: biological_process def: "Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of nitric oxide-mediated signal transduction" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction relationship: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction [Term] id: GO:0010752 name: regulation of cGMP-mediated signaling namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of cGMP-mediated signalling" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0010753 name: positive regulation of cGMP-mediated signaling namespace: biological_process def: "Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of cGMP-mediated signalling" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010752 ! regulation of cGMP-mediated signaling relationship: positively_regulates GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0010754 name: negative regulation of cGMP-mediated signaling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of cGMP-mediated signalling" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010752 ! regulation of cGMP-mediated signaling relationship: negatively_regulates GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0010755 name: regulation of plasminogen activation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage relationship: regulates GO:0031639 ! plasminogen activation [Term] id: GO:0010756 name: positive regulation of plasminogen activation namespace: biological_process def: "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010755 ! regulation of plasminogen activation is_a: GO:0010954 ! positive regulation of protein maturation by peptide bond cleavage relationship: positively_regulates GO:0031639 ! plasminogen activation [Term] id: GO:0010757 name: negative regulation of plasminogen activation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] synonym: "inhibition of plasminogen activation" NARROW [GOC:dph, GOC:tb] is_a: GO:0010755 ! regulation of plasminogen activation is_a: GO:0010955 ! negative regulation of protein maturation by peptide bond cleavage relationship: negatively_regulates GO:0031639 ! plasminogen activation [Term] id: GO:0010758 name: regulation of macrophage chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis relationship: regulates GO:0048246 ! macrophage chemotaxis [Term] id: GO:0010759 name: positive regulation of macrophage chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration relationship: positively_regulates GO:0048246 ! macrophage chemotaxis [Term] id: GO:0010760 name: negative regulation of macrophage chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis relationship: negatively_regulates GO:0048246 ! macrophage chemotaxis [Term] id: GO:0010761 name: fibroblast migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb] synonym: "fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0001667 ! ameboidal cell migration [Term] id: GO:0010762 name: regulation of fibroblast migration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0010761 ! fibroblast migration [Term] id: GO:0010763 name: positive regulation of fibroblast migration namespace: biological_process def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030335 ! positive regulation of cell migration relationship: positively_regulates GO:0010761 ! fibroblast migration [Term] id: GO:0010764 name: negative regulation of fibroblast migration namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030336 ! negative regulation of cell migration relationship: negatively_regulates GO:0010761 ! fibroblast migration [Term] id: GO:0010765 name: positive regulation of sodium ion transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043270 ! positive regulation of ion transport relationship: positively_regulates GO:0006814 ! sodium ion transport [Term] id: GO:0010766 name: negative regulation of sodium ion transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043271 ! negative regulation of ion transport relationship: negatively_regulates GO:0006814 ! sodium ion transport [Term] id: GO:0010767 name: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] is_a: GO:0034644 ! cellular response to UV is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress [Term] id: GO:0010768 name: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0010767 ! regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [Term] id: GO:0010769 name: regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010770 name: positive regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010771 name: negative regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010772 name: meiotic DNA recombinase assembly involved in reciprocal meiotic recombination namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000707 ! meiotic DNA recombinase assembly relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010773 name: meiotic DNA recombinase assembly involved in meiotic gene conversion namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000707 ! meiotic DNA recombinase assembly relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010774 name: meiotic strand invasion involved in reciprocal meiotic recombination namespace: biological_process def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000708 ! meiotic strand invasion relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010775 name: meiotic strand invasion involved in meiotic gene conversion namespace: biological_process def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination." [GOC:dph, GOC:tb] is_a: GO:0000708 ! meiotic strand invasion relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010776 name: meiotic mismatch repair involved in meiotic gene conversion namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000710 ! meiotic mismatch repair relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010777 name: meiotic mismatch repair involved in reciprocal meiotic recombination namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000710 ! meiotic mismatch repair relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010778 name: meiotic DNA repair synthesis involved in reciprocal meiotic recombination namespace: biological_process def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000711 ! meiotic DNA repair synthesis relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010779 name: meiotic DNA repair synthesis involved in meiotic gene conversion namespace: biological_process def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000711 ! meiotic DNA repair synthesis relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010780 name: meiotic DNA double-strand break formation involved in reciprocal meiotic recombination namespace: biological_process def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0042138 ! meiotic DNA double-strand break formation relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010781 name: meiotic DNA double-strand break formation involved in meiotic gene conversion namespace: biological_process def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0042138 ! meiotic DNA double-strand break formation relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010782 name: proboscis morphogenesis, labial disc-derived namespace: biological_process def: "The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized." [GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007454 ! labial disc morphogenesis relationship: part_of GO:0048734 ! proboscis morphogenesis [Term] id: GO:0010783 name: proboscis morphogenesis, eye-antennal disc-derived namespace: biological_process def: "The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized." [GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis relationship: part_of GO:0048734 ! proboscis morphogenesis [Term] id: GO:0010784 name: proboscis morphogenesis, clypeo-labral disc-derived namespace: biological_process def: "The process in which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized." [GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048734 ! proboscis morphogenesis [Term] id: GO:0010785 name: clathrin coating of Golgi vesicle, plasma membrane to endosome targeting namespace: biological_process def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048202 ! clathrin coating of Golgi vesicle relationship: part_of GO:0048201 ! vesicle targeting, plasma membrane to endosome [Term] id: GO:0010786 name: clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting namespace: biological_process def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048202 ! clathrin coating of Golgi vesicle relationship: part_of GO:0048203 ! vesicle targeting, trans-Golgi to endosome [Term] id: GO:0010787 name: COPI coating of Golgi vesicle, inter-Golgi cisterna namespace: biological_process def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048205 ! COPI coating of Golgi vesicle relationship: part_of GO:0048204 ! vesicle targeting, inter-Golgi cisterna [Term] id: GO:0010788 name: COPI coating of Golgi vesicle, cis-Golgi to rough ER namespace: biological_process def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048205 ! COPI coating of Golgi vesicle relationship: part_of GO:0048206 ! vesicle targeting, cis-Golgi to rough ER [Term] id: GO:0010789 name: meiotic sister chromatid cohesion involved in meiosis I namespace: biological_process def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I." [GOC:dph, GOC:tb] is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0010790 name: meiotic sister chromatid cohesion involved in meiosis II namespace: biological_process def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II." [GOC:dph, GOC:tb] is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0010791 name: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing." [GOC:dph, GOC:tb] is_a: GO:0000729 ! DNA double-strand break processing relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0010792 name: DNA double-strand break processing involved in repair via single-strand annealing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing." [GOC:dph, GOC:tb] is_a: GO:0000729 ! DNA double-strand break processing relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0010793 name: regulation of mRNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0046831 ! regulation of RNA export from nucleus relationship: regulates GO:0006406 ! mRNA export from nucleus [Term] id: GO:0010794 name: regulation of dolichol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [GOC:dph, GOC:tb] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0019408 ! dolichol biosynthetic process [Term] id: GO:0010795 name: regulation of ubiquinone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process relationship: regulates GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0010796 name: regulation of multivesicular body size namespace: biological_process def: "Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0051036 ! regulation of endosome size [Term] id: GO:0010797 name: regulation of multivesicular body size involved in endosome transport namespace: biological_process def: "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb] is_a: GO:0010796 ! regulation of multivesicular body size relationship: part_of GO:0032509 ! endosome transport via multivesicular body sorting pathway [Term] id: GO:0010798 name: regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism namespace: biological_process def: "Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin." [GOC:dph, GOC:tb] is_a: GO:0010796 ! regulation of multivesicular body size [Term] id: GO:0010799 name: regulation of peptidyl-threonine phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation relationship: regulates GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0010800 name: positive regulation of peptidyl-threonine phosphorylation namespace: biological_process def: "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation relationship: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0010801 name: negative regulation of peptidyl-threonine phosphorylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation relationship: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0010803 name: regulation of tumor necrosis factor-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] synonym: "regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] synonym: "regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway relationship: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway [Term] id: GO:0010804 name: negative regulation of tumor necrosis factor-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] synonym: "negative regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway relationship: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway [Term] id: GO:0010805 name: regulation of lysine import namespace: biological_process def: "Any process that modulates the rate or frequency of lysine import. Lysine import is the directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:dph, GOC:tb] synonym: "regulation of lysine uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0010958 ! regulation of amino acid import relationship: regulates GO:0034226 ! lysine import [Term] id: GO:0010806 name: negative regulation of lysine import namespace: biological_process def: "Any process that decreases the rate or frequency of lysine import. Lysine import is the directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of lysine uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0010805 ! regulation of lysine import is_a: GO:0051956 ! negative regulation of amino acid transport relationship: negatively_regulates GO:0034226 ! lysine import [Term] id: GO:0010807 name: regulation of synaptic vesicle priming namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis relationship: regulates GO:0016082 ! synaptic vesicle priming [Term] id: GO:0010808 name: positive regulation of synaptic vesicle priming namespace: biological_process def: "Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511] is_a: GO:0010807 ! regulation of synaptic vesicle priming is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0016082 ! synaptic vesicle priming [Term] id: GO:0010809 name: negative regulation of synaptic vesicle priming namespace: biological_process def: "Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmvs, GOC:tb, PMID:15489511] is_a: GO:0010807 ! regulation of synaptic vesicle priming is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0016082 ! synaptic vesicle priming [Term] id: GO:0010810 name: regulation of cell-substrate adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] is_a: GO:0030155 ! regulation of cell adhesion relationship: regulates GO:0031589 ! cell-substrate adhesion [Term] id: GO:0010811 name: positive regulation of cell-substrate adhesion namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] is_a: GO:0010810 ! regulation of cell-substrate adhesion is_a: GO:0045785 ! positive regulation of cell adhesion relationship: positively_regulates GO:0031589 ! cell-substrate adhesion [Term] id: GO:0010812 name: negative regulation of cell-substrate adhesion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0010810 ! regulation of cell-substrate adhesion relationship: negatively_regulates GO:0031589 ! cell-substrate adhesion [Term] id: GO:0010813 name: neuropeptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0010814 name: substance P catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P." [GOC:BHF, GOC:rl] is_a: GO:0010813 ! neuropeptide catabolic process [Term] id: GO:0010815 name: bradykinin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:BHF, GOC:rl] is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0010816 name: calcitonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl] is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0010817 name: regulation of hormone levels namespace: biological_process def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0010818 name: T cell chemotaxis namespace: biological_process def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb] synonym: "T-cell chemotaxis" EXACT [CL:0000084] is_a: GO:0048247 ! lymphocyte chemotaxis is_a: GO:0072678 ! T cell migration [Term] id: GO:0010819 name: regulation of T cell chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:2000404 ! regulation of T cell migration relationship: regulates GO:0010818 ! T cell chemotaxis [Term] id: GO:0010820 name: positive regulation of T cell chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0010819 ! regulation of T cell chemotaxis is_a: GO:2000406 ! positive regulation of T cell migration relationship: positively_regulates GO:0010818 ! T cell chemotaxis [Term] id: GO:0010821 name: regulation of mitochondrion organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010822 name: positive regulation of mitochondrion organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization relationship: positively_regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010823 name: negative regulation of mitochondrion organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization relationship: negatively_regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010824 name: regulation of centrosome duplication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] is_a: GO:0046605 ! regulation of centrosome cycle relationship: regulates GO:0051298 ! centrosome duplication [Term] id: GO:0010825 name: positive regulation of centrosome duplication namespace: biological_process def: "Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0010824 ! regulation of centrosome duplication relationship: positively_regulates GO:0051298 ! centrosome duplication [Term] id: GO:0010826 name: negative regulation of centrosome duplication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010824 ! regulation of centrosome duplication relationship: negatively_regulates GO:0051298 ! centrosome duplication [Term] id: GO:0010827 name: regulation of glucose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] xref: Reactome:1253381 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1280321 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1299170 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1326899 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1352991 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1393200 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1417695 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1450797 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1471211 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1483211 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1496896 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1514289 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1526904 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1532637 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:1536069 "Regulation of Glucokinase by Glucokinase Regulatory Protein" xref: Reactome:170822 "Regulation of Glucokinase by Glucokinase Regulatory Protein" is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0015758 ! glucose transport [Term] id: GO:0010828 name: positive regulation of glucose transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010827 ! regulation of glucose transport is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0015758 ! glucose transport [Term] id: GO:0010829 name: negative regulation of glucose transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010827 ! regulation of glucose transport is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0015758 ! glucose transport [Term] id: GO:0010830 name: regulation of myotube differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0048742 ! regulation of skeletal muscle fiber development relationship: regulates GO:0014902 ! myotube differentiation [Term] id: GO:0010831 name: positive regulation of myotube differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation relationship: positively_regulates GO:0014902 ! myotube differentiation [Term] id: GO:0010832 name: negative regulation of myotube differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation relationship: negatively_regulates GO:0014902 ! myotube differentiation [Term] id: GO:0010833 name: telomere maintenance via telomere lengthening namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0010834 name: telomere maintenance via telomere shortening namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA." [GOC:dph, GOC:tb] is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0010835 name: regulation of protein ADP-ribosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:dph, GOC:tb] synonym: "regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0010836 name: negative regulation of protein ADP-ribosylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf] is_a: GO:0010835 ! regulation of protein ADP-ribosylation is_a: GO:0031400 ! negative regulation of protein modification process relationship: negatively_regulates GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0010837 name: regulation of keratinocyte proliferation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0043616 ! keratinocyte proliferation [Term] id: GO:0010838 name: positive regulation of keratinocyte proliferation namespace: biological_process def: "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0010837 ! regulation of keratinocyte proliferation relationship: positively_regulates GO:0043616 ! keratinocyte proliferation [Term] id: GO:0010839 name: negative regulation of keratinocyte proliferation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0010837 ! regulation of keratinocyte proliferation relationship: negatively_regulates GO:0043616 ! keratinocyte proliferation [Term] id: GO:0010840 name: regulation of circadian sleep/wake cycle, wakefulness namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:dph, GOC:tb] is_a: GO:0042749 ! regulation of circadian sleep/wake cycle relationship: regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness [Term] id: GO:0010841 name: positive regulation of circadian sleep/wake cycle, wakefulness namespace: biological_process def: "Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness is_a: GO:0042753 ! positive regulation of circadian rhythm is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness [Term] id: GO:0010842 name: retina layer formation namespace: biological_process def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266] synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb] synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0010843 name: promoter binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factor complexes of the basal transcription machinery." [GOC:dph, GOC:tb, SO:0000167] comment: This term was made obsolete because the word "promoter" is used ambiguously in the literature. It sometimes is used to refer specifically to the "core promoter" region recognized by the basal transcription machinery, and other times is used to refer to a larger regulatory region composed of the core promoter and also the regulatory region adjacent (proximal) to the core promoter. The core promoter proximal region is typically recognized by "regulatory transcription factors", such as Gal4 in S. cerevisiae. synonym: "DNA binding, transcription promoter" EXACT [GOC:dph, GOC:tb] is_obsolete: true consider: GO:0044212 [Term] id: GO:0010844 name: recombination hotspot binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region in a genome which promotes recombination." [GOC:dph, GOC:tb] synonym: "DNA binding, recombination hotspot" EXACT [GOC:dph, GOC:tb] is_a: GO:0003677 ! DNA binding [Term] id: GO:0010845 name: positive regulation of reciprocal meiotic recombination namespace: biological_process def: "Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] synonym: "positive regulation of meiotic recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0010520 ! regulation of reciprocal meiotic recombination is_a: GO:0045836 ! positive regulation of meiosis is_a: GO:0045911 ! positive regulation of DNA recombination relationship: positively_regulates GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010846 name: activation of reciprocal meiotic recombination namespace: biological_process def: "Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] synonym: "activation of meiotic recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0010845 ! positive regulation of reciprocal meiotic recombination [Term] id: GO:0010847 name: regulation of chromatin assembly namespace: biological_process def: "Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [GOC:dph, GOC:tb] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly is_a: GO:0044087 ! regulation of cellular component biogenesis relationship: regulates GO:0031497 ! chromatin assembly [Term] id: GO:0010848 name: regulation of chromatin disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [GOC:dph, GOC:tb] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly relationship: regulates GO:0031498 ! chromatin disassembly [Term] id: GO:0010849 name: regulation of proton-transporting ATPase activity, rotational mechanism namespace: biological_process def: "Any process that modulates the rate of ATP hydrolysis by an ATPase. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [GOC:dph, GOC:tb] synonym: "regulation of hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of V-type ATPase activity" BROAD [GOC:dph, GOC:tb] is_a: GO:0010155 ! regulation of proton transport is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0043462 ! regulation of ATPase activity [Term] id: GO:0010850 name: chemoreceptor signaling pathway involved in regulation of blood pressure namespace: biological_process def: "A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb] synonym: "chemoreceptor signalling pathway involved in regulation of blood pressure" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0010851 name: cyclase regulator activity namespace: molecular_function def: "Modulates the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0010852 name: cyclase inhibitor activity namespace: molecular_function def: "Decreases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0010853 name: cyclase activator activity namespace: molecular_function def: "Increases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0010854 name: adenylate cyclase regulator activity namespace: molecular_function def: "Modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0010855 name: adenylate cyclase inhibitor activity namespace: molecular_function def: "Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] is_a: GO:0010854 ! adenylate cyclase regulator activity [Term] id: GO:0010856 name: adenylate cyclase activator activity namespace: molecular_function def: "Increases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] is_a: GO:0010854 ! adenylate cyclase regulator activity [Term] id: GO:0010857 name: calcium-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium." [GOC:dph, GOC:tb] is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0010858 name: calcium-dependent protein kinase regulator activity namespace: molecular_function def: "Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner." [GOC:dph, GOC:tb] is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0010859 name: calcium-dependent cysteine-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner." [GOC:dph, GOC:tb] is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity [Term] id: GO:0010860 name: proteasome regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:dph, GOC:tb] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. is_obsolete: true consider: GO:0061135 consider: GO:0061136 [Term] id: GO:0010861 name: thyroid hormone receptor activator activity namespace: molecular_function def: "A receptor activator activity that binds to, thyroid hormone receptor in a ligand-dependent manner and enhances ligand-induced transcriptional activity of the receptor." [GOC:dph, GOC:mah, GOC:tb, PMID:9346901] is_a: GO:0030546 ! receptor activator activity [Term] id: GO:0010862 name: positive regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation [Term] id: GO:0010863 name: positive regulation of phospholipase C activity namespace: biological_process def: "Any process that increases the rate of phospholipase C activity." [GOC:dph, GOC:tb] is_a: GO:0010518 ! positive regulation of phospholipase activity [Term] id: GO:0010864 name: positive regulation of protein histidine kinase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of protein histidine kinase activity." [GOC:dph, GOC:tb] is_a: GO:0032110 ! regulation of protein histidine kinase activity is_a: GO:0045860 ! positive regulation of protein kinase activity [Term] id: GO:0010865 name: stipule development namespace: biological_process def: "The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms." [GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048366 ! leaf development [Term] id: GO:0010866 name: regulation of triglyceride biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] synonym: "regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:0090207 ! regulation of triglyceride metabolic process relationship: regulates GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0010867 name: positive regulation of triglyceride biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] synonym: "positive regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] is_a: GO:0010866 ! regulation of triglyceride biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0090208 ! positive regulation of triglyceride metabolic process relationship: positively_regulates GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0010868 name: negative regulation of triglyceride biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] synonym: "negative regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] is_a: GO:0010866 ! regulation of triglyceride biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0090209 ! negative regulation of triglyceride metabolic process relationship: negatively_regulates GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0010869 name: regulation of receptor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0032800 ! receptor biosynthetic process [Term] id: GO:0010870 name: positive regulation of receptor biosynthetic process namespace: biological_process def: "Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010869 ! regulation of receptor biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process relationship: positively_regulates GO:0032800 ! receptor biosynthetic process [Term] id: GO:0010871 name: negative regulation of receptor biosynthetic process namespace: biological_process def: "Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010869 ! regulation of receptor biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process relationship: negatively_regulates GO:0032800 ! receptor biosynthetic process [Term] id: GO:0010872 name: regulation of cholesterol esterification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:dph, GOC:tb] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0034435 ! cholesterol esterification [Term] id: GO:0010873 name: positive regulation of cholesterol esterification namespace: biological_process def: "Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010872 ! regulation of cholesterol esterification is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process relationship: positively_regulates GO:0034435 ! cholesterol esterification [Term] id: GO:0010874 name: regulation of cholesterol efflux namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032374 ! regulation of cholesterol transport relationship: regulates GO:0033344 ! cholesterol efflux [Term] id: GO:0010875 name: positive regulation of cholesterol efflux namespace: biological_process def: "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010874 ! regulation of cholesterol efflux is_a: GO:0032376 ! positive regulation of cholesterol transport relationship: positively_regulates GO:0033344 ! cholesterol efflux [Term] id: GO:0010876 name: lipid localization namespace: biological_process def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb] synonym: "lipid localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0010877 name: lipid transport involved in lipid storage namespace: biological_process def: "The directed movement of lipids into cells that is part of their accumulation and maintenance." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0006869 ! lipid transport relationship: part_of GO:0019915 ! lipid storage [Term] id: GO:0010878 name: cholesterol storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] synonym: "cholesterol sequestration" NARROW [GOC:dph, GOC:tb] synonym: "sequestration of cholesterol" NARROW [GOC:dph, GOC:tb] is_a: GO:0019915 ! lipid storage [Term] id: GO:0010879 name: cholesterol transport involved in cholesterol storage namespace: biological_process def: "The directed movement of cholesterol into cells that is part of their accumulation and maintenance." [GOC:dph, GOC:tb] is_a: GO:0010877 ! lipid transport involved in lipid storage is_a: GO:0030301 ! cholesterol transport relationship: part_of GO:0010878 ! cholesterol storage [Term] id: GO:0010880 name: regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum namespace: biological_process def: "Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol relationship: regulates GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [Term] id: GO:0010881 name: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum is_a: GO:0010882 ! regulation of cardiac muscle contraction by calcium ion signaling [Term] id: GO:0010882 name: regulation of cardiac muscle contraction by calcium ion signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of cardiac muscle contraction by calcium ion signalling" EXACT [GOC:mah] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0055117 ! regulation of cardiac muscle contraction [Term] id: GO:0010883 name: regulation of lipid storage namespace: biological_process def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0032879 ! regulation of localization relationship: regulates GO:0019915 ! lipid storage [Term] id: GO:0010884 name: positive regulation of lipid storage namespace: biological_process def: "Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0019915 ! lipid storage [Term] id: GO:0010885 name: regulation of cholesterol storage namespace: biological_process def: "Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage relationship: regulates GO:0010878 ! cholesterol storage [Term] id: GO:0010886 name: positive regulation of cholesterol storage namespace: biological_process def: "Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0010884 ! positive regulation of lipid storage is_a: GO:0010885 ! regulation of cholesterol storage relationship: positively_regulates GO:0010878 ! cholesterol storage [Term] id: GO:0010887 name: negative regulation of cholesterol storage namespace: biological_process def: "Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0010885 ! regulation of cholesterol storage is_a: GO:0010888 ! negative regulation of lipid storage relationship: negatively_regulates GO:0010878 ! cholesterol storage [Term] id: GO:0010888 name: negative regulation of lipid storage namespace: biological_process def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0019915 ! lipid storage [Term] id: GO:0010889 name: regulation of sequestering of triglyceride namespace: biological_process def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of sequestering of triacylglycerol" EXACT [GOC:mah] synonym: "regulation of triacylglycerol sequestration" EXACT [GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage relationship: regulates GO:0030730 ! sequestering of triglyceride [Term] id: GO:0010890 name: positive regulation of sequestering of triglyceride namespace: biological_process def: "Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of sequestering of triacylglycerol" EXACT [GOC:mah] synonym: "positive regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb] is_a: GO:0010884 ! positive regulation of lipid storage is_a: GO:0010889 ! regulation of sequestering of triglyceride relationship: positively_regulates GO:0030730 ! sequestering of triglyceride [Term] id: GO:0010891 name: negative regulation of sequestering of triglyceride namespace: biological_process def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of sequestering of triacylglycerol" EXACT [GOC:mah] synonym: "negative regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb] is_a: GO:0010888 ! negative regulation of lipid storage is_a: GO:0010889 ! regulation of sequestering of triglyceride relationship: negatively_regulates GO:0030730 ! sequestering of triglyceride [Term] id: GO:0010892 name: positive regulation of mitochondrial translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0070131 ! positive regulation of mitochondrial translation [Term] id: GO:0010893 name: positive regulation of steroid biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb] is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process relationship: positively_regulates GO:0006694 ! steroid biosynthetic process [Term] id: GO:0010894 name: negative regulation of steroid biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb] is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process relationship: negatively_regulates GO:0006694 ! steroid biosynthetic process [Term] id: GO:0010895 name: negative regulation of ergosterol biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:tb] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0032443 ! regulation of ergosterol biosynthetic process relationship: negatively_regulates GO:0006696 ! ergosterol biosynthetic process [Term] id: GO:0010896 name: regulation of triglyceride catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] synonym: "regulation of triacylglycerol catabolic process" EXACT [GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0050994 ! regulation of lipid catabolic process is_a: GO:0090207 ! regulation of triglyceride metabolic process relationship: regulates GO:0019433 ! triglyceride catabolic process [Term] id: GO:0010897 name: negative regulation of triglyceride catabolic process namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] synonym: "negative regulation of triacylglycerol catabolic process" EXACT [GOC:mah] is_a: GO:0010896 ! regulation of triglyceride catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:0090209 ! negative regulation of triglyceride metabolic process relationship: negatively_regulates GO:0019433 ! triglyceride catabolic process [Term] id: GO:0010898 name: positive regulation of triglyceride catabolic process namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] synonym: "positive regulation of triacylglycerol catabolic process" EXACT [GOC:mah] is_a: GO:0010896 ! regulation of triglyceride catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:0090208 ! positive regulation of triglyceride metabolic process relationship: positively_regulates GO:0019433 ! triglyceride catabolic process [Term] id: GO:0010899 name: regulation of phosphatidylcholine catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb] is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0060696 ! regulation of phospholipid catabolic process relationship: regulates GO:0034638 ! phosphatidylcholine catabolic process [Term] id: GO:0010900 name: negative regulation of phosphatidylcholine catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb] is_a: GO:0010899 ! regulation of phosphatidylcholine catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process relationship: negatively_regulates GO:0034638 ! phosphatidylcholine catabolic process [Term] id: GO:0010901 name: regulation of very-low-density lipoprotein particle remodeling namespace: biological_process def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] synonym: "regulation of VLDL remodeling" EXACT [GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0034372 ! very-low-density lipoprotein particle remodeling [Term] id: GO:0010902 name: positive regulation of very-low-density lipoprotein particle remodeling namespace: biological_process def: "Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] synonym: "positive regulation of VLDL remodeling" EXACT [GOC:tb] is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling [Term] id: GO:0010903 name: negative regulation of very-low-density lipoprotein particle remodeling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] synonym: "negative regulation of VLDL remodeling" EXACT [GOC:tb] is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling [Term] id: GO:0010904 name: regulation of UDP-glucose catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb] synonym: "regulation of UDP-glucose catabolism" EXACT [GOC:tb] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process relationship: regulates GO:0006258 ! UDP-glucose catabolic process [Term] id: GO:0010905 name: negative regulation of UDP-glucose catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb] synonym: "negative regulation of UDP-glucose catabolism" EXACT [GOC:tb] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0010904 ! regulation of UDP-glucose catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: negatively_regulates GO:0006258 ! UDP-glucose catabolic process [Term] id: GO:0010906 name: regulation of glucose metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process relationship: regulates GO:0006006 ! glucose metabolic process [Term] id: GO:0010907 name: positive regulation of glucose metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0010906 ! regulation of glucose metabolic process relationship: positively_regulates GO:0006006 ! glucose metabolic process [Term] id: GO:0010908 name: regulation of heparan sulfate proteoglycan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process relationship: regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0010909 name: positive regulation of heparan sulfate proteoglycan biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0010908 ! regulation of heparan sulfate proteoglycan biosynthetic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process relationship: positively_regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0010910 name: positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate." [GOC:dph, GOC:tb] is_a: GO:0010909 ! positive regulation of heparan sulfate proteoglycan biosynthetic process is_a: GO:0010912 ! positive regulation of isomerase activity [Term] id: GO:0010911 name: regulation of isomerase activity namespace: biological_process def: "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0010912 name: positive regulation of isomerase activity namespace: biological_process def: "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb] is_a: GO:0010911 ! regulation of isomerase activity is_a: GO:0043085 ! positive regulation of catalytic activity [Term] id: GO:0010913 name: regulation of sterigmatocystin biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process relationship: regulates GO:0045461 ! sterigmatocystin biosynthetic process [Term] id: GO:0010914 name: positive regulation of sterigmatocystin biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb] is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process relationship: positively_regulates GO:0045461 ! sterigmatocystin biosynthetic process [Term] id: GO:0010915 name: regulation of very-low-density lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb] synonym: "regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance relationship: regulates GO:0034447 ! very-low-density lipoprotein particle clearance [Term] id: GO:0010916 name: negative regulation of very-low-density lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb] is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance relationship: negatively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance [Term] id: GO:0010917 name: negative regulation of mitochondrial membrane potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb] synonym: "reduction of mitochondrial membrane potential" EXACT [GOC:rph] is_a: GO:0045837 ! negative regulation of membrane potential is_a: GO:0051881 ! regulation of mitochondrial membrane potential [Term] id: GO:0010918 name: positive regulation of mitochondrial membrane potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb] synonym: "elevation of mitochondrial membrane potential" EXACT [GOC:rph] is_a: GO:0045838 ! positive regulation of membrane potential is_a: GO:0051881 ! regulation of mitochondrial membrane potential [Term] id: GO:0010919 name: regulation of inositol phosphate biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process relationship: regulates GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0010920 name: negative regulation of inositol phosphate biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb] synonym: "negative regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process relationship: negatively_regulates GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0010921 name: regulation of phosphatase activity namespace: biological_process def: "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0035303 ! regulation of dephosphorylation is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0010922 name: positive regulation of phosphatase activity namespace: biological_process def: "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0010923 name: negative regulation of phosphatase activity namespace: biological_process def: "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0010924 name: regulation of inositol-polyphosphate 5-phosphatase activity namespace: biological_process def: "Any process that modulates the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity [Term] id: GO:0010925 name: positive regulation of inositol-polyphosphate 5-phosphatase activity namespace: biological_process def: "Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0010924 ! regulation of inositol-polyphosphate 5-phosphatase activity [Term] id: GO:0010926 name: anatomical structure formation namespace: biological_process def: "OBSOLETE. The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structure is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:tb] comment: The reason for obsoletion is that the term is confusing - it sounds developmental and has a developmental sounding def, but it is not a child of developmental process and its children included 'cellular component assembly'. The term was created to group together 'cellular component assembly' and 'anatomical structure formation involved in morphogenesis', but we no longer feel that this grouping is useful. is_obsolete: true consider: GO:0022607 consider: GO:0048646 [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0032989 ! cellular component morphogenesis [Term] id: GO:0010928 name: regulation of auxin mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] synonym: "regulation of auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0009734 ! auxin mediated signaling pathway [Term] id: GO:0010929 name: positive regulation of auxin mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] synonym: "positive regulation of auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010928 ! regulation of auxin mediated signaling pathway relationship: positively_regulates GO:0009734 ! auxin mediated signaling pathway [Term] id: GO:0010930 name: negative regulation of auxin mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] synonym: "negative regulation of auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010928 ! regulation of auxin mediated signaling pathway relationship: negatively_regulates GO:0009734 ! auxin mediated signaling pathway [Term] id: GO:0010931 name: macrophage tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in macrophages." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0010932 name: regulation of macrophage tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0010931 ! macrophage tolerance induction [Term] id: GO:0010933 name: positive regulation of macrophage tolerance induction namespace: biological_process def: "Any process that increases the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0010932 ! regulation of macrophage tolerance induction relationship: positively_regulates GO:0010931 ! macrophage tolerance induction [Term] id: GO:0010934 name: macrophage cytokine production namespace: biological_process def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0010935 name: regulation of macrophage cytokine production namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0010934 ! macrophage cytokine production [Term] id: GO:0010936 name: negative regulation of macrophage cytokine production namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0010935 ! regulation of macrophage cytokine production relationship: negatively_regulates GO:0010934 ! macrophage cytokine production [Term] id: GO:0010937 name: regulation of cytoplasmic microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb] is_a: GO:0031114 ! regulation of microtubule depolymerization relationship: regulates GO:0010938 ! cytoplasmic microtubule depolymerization [Term] id: GO:0010938 name: cytoplasmic microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb] is_a: GO:0007019 ! microtubule depolymerization is_a: GO:0031122 ! cytoplasmic microtubule organization [Term] id: GO:0010939 name: regulation of necrotic cell death namespace: biological_process def: "Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998] is_a: GO:0010941 ! regulation of cell death relationship: regulates GO:0070265 ! necrotic cell death [Term] id: GO:0010940 name: positive regulation of necrotic cell death namespace: biological_process def: "Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998] is_a: GO:0010939 ! regulation of necrotic cell death is_a: GO:0010942 ! positive regulation of cell death relationship: positively_regulates GO:0070265 ! necrotic cell death [Term] id: GO:0010941 name: regulation of cell death namespace: biological_process def: "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0008219 ! cell death [Term] id: GO:0010942 name: positive regulation of cell death namespace: biological_process def: "Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0010941 ! regulation of cell death is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0008219 ! cell death [Term] id: GO:0010943 name: NADPH pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H2O = NMNH + ADP." [GOC:tb] is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0010944 name: negative regulation of transcription by competitive promoter binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site." [GOC:tb] is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0010945 name: CoA pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme A + H2O = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb] is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0010946 name: regulation of meiotic joint molecule formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb] is_a: GO:0010520 ! regulation of reciprocal meiotic recombination relationship: regulates GO:0000709 ! meiotic joint molecule formation [Term] id: GO:0010947 name: negative regulation of meiotic joint molecule formation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb] is_a: GO:0010946 ! regulation of meiotic joint molecule formation is_a: GO:0010948 ! negative regulation of cell cycle process relationship: negatively_regulates GO:0000709 ! meiotic joint molecule formation [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0022402 ! cell cycle process [Term] id: GO:0010949 name: negative regulation of intestinal phytosterol absorption namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032372 ! negative regulation of sterol transport is_a: GO:0060457 ! negative regulation of digestive system process relationship: negatively_regulates GO:0060752 ! intestinal phytosterol absorption [Term] id: GO:0010950 name: positive regulation of endopeptidase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:0052548 ! regulation of endopeptidase activity [Term] id: GO:0010951 name: negative regulation of endopeptidase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:0052548 ! regulation of endopeptidase activity [Term] id: GO:0010952 name: positive regulation of peptidase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity [Term] id: GO:0010953 name: regulation of protein maturation by peptide bond cleavage namespace: biological_process def: "Any process that modulates the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0070613 ! regulation of protein processing relationship: regulates GO:0051605 ! protein maturation by peptide bond cleavage [Term] id: GO:0010954 name: positive regulation of protein maturation by peptide bond cleavage namespace: biological_process def: "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage is_a: GO:0045862 ! positive regulation of proteolysis relationship: positively_regulates GO:0051605 ! protein maturation by peptide bond cleavage [Term] id: GO:0010955 name: negative regulation of protein maturation by peptide bond cleavage namespace: biological_process def: "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage is_a: GO:0045861 ! negative regulation of proteolysis relationship: negatively_regulates GO:0051605 ! protein maturation by peptide bond cleavage [Term] id: GO:0010956 name: negative regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity [Term] id: GO:0010957 name: negative regulation of vitamin D biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0060556 ! regulation of vitamin D biosynthetic process relationship: negatively_regulates GO:0042368 ! vitamin D biosynthetic process [Term] id: GO:0010958 name: regulation of amino acid import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid import. Amino acid import is the directed movement of amino acids into a cell or organelle." [GOC:dph, GOC:tb] is_a: GO:0051955 ! regulation of amino acid transport relationship: regulates GO:0043090 ! amino acid import [Term] id: GO:0010959 name: regulation of metal ion transport namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of ion transport relationship: regulates GO:0030001 ! metal ion transport [Term] id: GO:0010960 name: magnesium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0010961 name: cellular magnesium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell." [GOC:dph, GOC:tb] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0010960 ! magnesium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0010962 name: regulation of glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0009250 ! glucan biosynthetic process [Term] id: GO:0010963 name: regulation of L-arginine import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:dph, GOC:tb] is_a: GO:0010958 ! regulation of amino acid import relationship: regulates GO:0043091 ! L-arginine import [Term] id: GO:0010964 name: regulation of chromatin silencing by small RNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:tb] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:0060966 ! regulation of gene silencing by RNA relationship: regulates GO:0031048 ! chromatin silencing by small RNA [Term] id: GO:0010965 name: regulation of mitotic sister chromatid separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation relationship: regulates GO:0051306 ! mitotic sister chromatid separation [Term] id: GO:0010966 name: regulation of phosphate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0044070 ! regulation of anion transport relationship: regulates GO:0006817 ! phosphate transport [Term] id: GO:0010967 name: regulation of polyamine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [GOC:dph, GOC:tb] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0006596 ! polyamine biosynthetic process [Term] id: GO:0010968 name: regulation of microtubule nucleation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: regulates GO:0007020 ! microtubule nucleation [Term] id: GO:0010969 name: regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion relationship: regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion [Term] id: GO:0010970 name: microtubule-based transport namespace: biological_process def: "Microtubule-based movement that results in the net, directed movement of organelles or other particles from one location in the cell to another." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport [Term] id: GO:0010971 name: positive regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:tb] synonym: "positive regulation of mitotic entry" EXACT [GOC:mah] is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0010972 name: negative regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that decreases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:tb] synonym: "negative regulation of mitotic entry" EXACT [GOC:vw] is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle relationship: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0010973 name: positive regulation of barrier septum formation namespace: biological_process def: "Any process that increases the frequency, rate or extent of barrier septum formation. Barrier septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:dph, GOC:tb] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:0032955 ! regulation of barrier septum formation is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0000917 ! barrier septum formation [Term] id: GO:0010974 name: negative regulation of barrier septum formation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of barrier septum formation. Barrier septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:dph, GOC:tb] is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:0032955 ! regulation of barrier septum formation is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0000917 ! barrier septum formation [Term] id: GO:0010975 name: regulation of neuron projection development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "regulation of neurite development" NARROW [GOC:mah] synonym: "regulation of neurite formation" NARROW [GOC:mah] synonym: "regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0045664 ! regulation of neuron differentiation relationship: regulates GO:0031175 ! neuron projection development [Term] id: GO:0010976 name: positive regulation of neuron projection development namespace: biological_process def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "positive regulation of neurite development" NARROW [GOC:mah] synonym: "positive regulation of neurite formation" NARROW [GOC:mah] synonym: "positive regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031346 ! positive regulation of cell projection organization relationship: positively_regulates GO:0031175 ! neuron projection development [Term] id: GO:0010977 name: negative regulation of neuron projection development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "negative regulation of neurite development" NARROW [GOC:mah] synonym: "negative regulation of neurite formation" NARROW [GOC:mah] synonym: "negative regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031345 ! negative regulation of cell projection organization relationship: negatively_regulates GO:0031175 ! neuron projection development [Term] id: GO:0010978 name: gene silencing involved in chronological cell aging namespace: biological_process def: "Any transcriptional or post-transcriptional process, arising in non-dividing cells as they age, carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0016458 ! gene silencing relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0010979 name: regulation of vitamin D 24-hydroxylase activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051341 ! regulation of oxidoreductase activity [Term] id: GO:0010980 name: positive regulation of vitamin D 24-hydroxylase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010979 ! regulation of vitamin D 24-hydroxylase activity is_a: GO:0051353 ! positive regulation of oxidoreductase activity [Term] id: GO:0010981 name: regulation of cell wall macromolecule metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell wall macromolecule metabolism. Cell wall macromolecule metabolic processes are the chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:tb] is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0044036 ! cell wall macromolecule metabolic process [Term] id: GO:0010982 name: regulation of high-density lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance relationship: regulates GO:0034384 ! high-density lipoprotein particle clearance [Term] id: GO:0010983 name: positive regulation of high-density lipoprotein particle clearance namespace: biological_process def: "Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance relationship: positively_regulates GO:0034384 ! high-density lipoprotein particle clearance [Term] id: GO:0010984 name: regulation of lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0010985 name: negative regulation of lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0010986 name: positive regulation of lipoprotein particle clearance namespace: biological_process def: "Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0010987 name: negative regulation of high-density lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance relationship: negatively_regulates GO:0034384 ! high-density lipoprotein particle clearance [Term] id: GO:0010988 name: regulation of low-density lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance relationship: regulates GO:0034383 ! low-density lipoprotein particle clearance [Term] id: GO:0010989 name: negative regulation of low-density lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance relationship: negatively_regulates GO:0034383 ! low-density lipoprotein particle clearance [Term] id: GO:0010990 name: regulation of SMAD protein complex assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0007183 ! SMAD protein complex assembly [Term] id: GO:0010991 name: negative regulation of SMAD protein complex assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010990 ! regulation of SMAD protein complex assembly is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0007183 ! SMAD protein complex assembly [Term] id: GO:0010992 name: ubiquitin homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0019725 ! cellular homeostasis [Term] id: GO:0010993 name: regulation of ubiquitin homeostasis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of ubiquitin homeostasis. Ubiquitin homeostasis is any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0010992 ! ubiquitin homeostasis [Term] id: GO:0010994 name: free ubiquitin chain polymerization namespace: biological_process def: "The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein." [GOC:BHF, GOC:dph, GOC:tb] xref: Reactome:433936 "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TIKAM1" xref: Reactome:451470 "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6" xref: Reactome:573294 "Activated TRAF6 synthesizes free K63 linked pUb chains." is_a: GO:0051258 ! protein polymerization relationship: part_of GO:0010993 ! regulation of ubiquitin homeostasis [Term] id: GO:0010995 name: free ubiquitin chain depolymerization namespace: biological_process def: "The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051261 ! protein depolymerization relationship: part_of GO:0010993 ! regulation of ubiquitin homeostasis [Term] id: GO:0010996 name: response to auditory stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb] synonym: "response to sound" EXACT [GOC:dph, GOC:sl, GOC:tb] synonym: "response to sound stimulus" EXACT [GOC:dph, GOC:tb] is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0010997 name: anaphase-promoting complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb] synonym: "APC binding" EXACT [GOC:dph, GOC:tb] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0010998 name: regulation of translational initiation by eIF2 alpha phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0043558 ! regulation of translational initiation in response to stress [Term] id: GO:0010999 name: regulation of eIF2 alpha phosphorylation by heme namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation [Term] id: GO:0011000 name: replication fork arrest at mating type locus namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus." [GOC:dph, GOC:tb] is_a: GO:0043111 ! replication fork arrest [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "Cell death resulting from activation of endogenous cellular processes." [GOC:lr] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] xref: Wikipedia:Programmed_cell_death is_a: GO:0008219 ! cell death [Term] id: GO:0012502 name: induction of programmed cell death namespace: biological_process alt_id: GO:0012503 def: "A process which directly activates any of the steps required for programmed cell death." [GOC:lr] synonym: "induction of non-apoptotic programmed cell death" NARROW [] synonym: "induction of nonapoptotic programmed cell death" NARROW [] is_a: GO:0043068 ! positive regulation of programmed cell death [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_candida subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0044464 ! cell part [Term] id: GO:0012506 name: vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah] xref: NIF_Subcellular:sao1153182838 is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0012505 ! endomembrane system relationship: part_of GO:0031988 ! membrane-bounded vesicle [Term] id: GO:0012507 name: ER to Golgi transport vesicle membrane namespace: cellular_component alt_id: GO:0030664 def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "COPII coated vesicle membrane" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT [] synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT [] synonym: "ER-Golgi transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030134 ! ER to Golgi transport vesicle [Term] id: GO:0012508 name: Golgi to ER transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai] synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" EXACT [] synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" EXACT [] synonym: "Golgi-ER transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030663 ! COPI coated vesicle membrane relationship: part_of GO:0030142 ! Golgi to ER transport vesicle [Term] id: GO:0012509 name: inter-Golgi transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030663 ! COPI coated vesicle membrane relationship: part_of GO:0030143 ! inter-Golgi transport vesicle [Term] id: GO:0012510 name: trans-Golgi network transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai] synonym: "TGN transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030660 ! Golgi-associated vesicle membrane is_a: GO:0030665 ! clathrin coated vesicle membrane relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle [Term] id: GO:0012511 name: monolayer-surrounded lipid storage body namespace: cellular_component alt_id: GO:0009520 def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372] synonym: "oil body" EXACT [] synonym: "oilbody" EXACT [] synonym: "oleosome" EXACT [] synonym: "spherosome" EXACT [] xref: Wikipedia:Oil_body is_a: GO:0005811 ! lipid particle is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0014001 name: sclerenchyma cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable." [CL:0000276, GOC:ef, GOC:jid, PO:0000077] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0014002 name: astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef] synonym: "astrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0048708 ! astrocyte differentiation [Term] id: GO:0014003 name: oligodendrocyte development namespace: biological_process def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef] synonym: "oligodendrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0014004 name: microglia differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef] synonym: "microglial cell differentiation" EXACT [] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0014005 name: microglia development namespace: biological_process def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef] synonym: "microglial cell development" EXACT [] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0014004 ! microglia differentiation [Term] id: GO:0014006 name: regulation of microglia differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "regulation of microglial cell differentiation" EXACT [] is_a: GO:0045685 ! regulation of glial cell differentiation relationship: regulates GO:0014004 ! microglia differentiation [Term] id: GO:0014007 name: negative regulation of microglia differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "down regulation of microglia differentiation" EXACT [] synonym: "down-regulation of microglia differentiation" EXACT [] synonym: "downregulation of microglia differentiation" EXACT [] synonym: "inhibition of microglia differentiation" NARROW [] synonym: "negative regulation of microglial cell differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation relationship: negatively_regulates GO:0014004 ! microglia differentiation [Term] id: GO:0014008 name: positive regulation of microglia differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "activation of microglia differentiation" NARROW [] synonym: "positive regulation of microglial cell differentiation" EXACT [] synonym: "stimulation of microglia differentiation" NARROW [] synonym: "up regulation of microglia differentiation" EXACT [] synonym: "up-regulation of microglia differentiation" EXACT [] synonym: "upregulation of microglia differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation relationship: positively_regulates GO:0014004 ! microglia differentiation [Term] id: GO:0014009 name: glial cell proliferation namespace: biological_process def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585] synonym: "glia proliferation" EXACT [] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0014010 name: Schwann cell proliferation namespace: biological_process def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585] is_a: GO:0014009 ! glial cell proliferation [Term] id: GO:0014011 name: Schwann cell proliferation involved in axon regeneration namespace: biological_process def: "The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system." [GOC:ef, ISBN:0878932585] is_a: GO:0014010 ! Schwann cell proliferation relationship: part_of GO:0014012 ! peripheral nervous system axon regeneration [Term] id: GO:0014012 name: peripheral nervous system axon regeneration namespace: biological_process def: "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury." [GOC:ef] synonym: "axon regeneration in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0031103 ! axon regeneration [Term] id: GO:0014013 name: regulation of gliogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] is_a: GO:0050767 ! regulation of neurogenesis relationship: regulates GO:0042063 ! gliogenesis [Term] id: GO:0014014 name: negative regulation of gliogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "down regulation of gliogenesis" EXACT [] synonym: "down-regulation of gliogenesis" EXACT [] synonym: "downregulation of gliogenesis" EXACT [] synonym: "inhibition of gliogenesis" NARROW [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050768 ! negative regulation of neurogenesis relationship: negatively_regulates GO:0042063 ! gliogenesis [Term] id: GO:0014015 name: positive regulation of gliogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "activation of gliogenesis" NARROW [] synonym: "stimulation of gliogenesis" NARROW [] synonym: "up regulation of gliogenesis" EXACT [] synonym: "up-regulation of gliogenesis" EXACT [] synonym: "upregulation of gliogenesis" EXACT [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050769 ! positive regulation of neurogenesis relationship: positively_regulates GO:0042063 ! gliogenesis [Term] id: GO:0014016 name: neuroblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0014017 name: neuroblast fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0014016 ! neuroblast differentiation [Term] id: GO:0014018 name: neuroblast fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0014017 ! neuroblast fate commitment [Term] id: GO:0014019 name: neuroblast development namespace: biological_process def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] is_a: GO:0048468 ! cell development relationship: part_of GO:0014016 ! neuroblast differentiation [Term] id: GO:0014020 name: primary neural tube formation namespace: biological_process def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585] synonym: "primary neural tube morphogenesis" EXACT [GOC:dph] synonym: "primary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0014021 name: secondary neural tube formation namespace: biological_process alt_id: GO:0014026 def: "The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals." [GOC:ef, ISBN:0878932585] synonym: "medullary cord biosynthesis" EXACT [] synonym: "medullary cord formation" EXACT [] synonym: "neural rod formation" RELATED [] synonym: "secondary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0014022 name: neural plate elongation namespace: biological_process def: "The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions." [GOC:ef, ISBN:0878932585] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0014023 name: neural rod formation namespace: biological_process def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0014024 name: neural rod cavitation namespace: biological_process def: "The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0014025 name: neural keel formation namespace: biological_process def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0014023 ! neural rod formation [Term] id: GO:0014027 name: secondary neural tube rod cavitation namespace: biological_process def: "The process of medullary cavitation, which is the formation of a lumen in the medullary cord during secondary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] synonym: "medullary rod cavitation" EXACT [] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0014021 ! secondary neural tube formation [Term] id: GO:0014028 name: notochord formation namespace: biological_process def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0048570 ! notochord morphogenesis [Term] id: GO:0014029 name: neural crest formation namespace: biological_process def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:dh, GOC:ef] is_a: GO:0001837 ! epithelial to mesenchymal transition relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0014030 name: mesenchymal cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a mesenchymal cell." [GOC:dh, GOC:ef] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0048762 ! mesenchymal cell differentiation [Term] id: GO:0014031 name: mesenchymal cell development namespace: biological_process def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0048468 ! cell development relationship: part_of GO:0048762 ! mesenchymal cell differentiation [Term] id: GO:0014032 name: neural crest cell development namespace: biological_process def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0014031 ! mesenchymal cell development relationship: part_of GO:0014033 ! neural crest cell differentiation [Term] id: GO:0014033 name: neural crest cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef] is_a: GO:0048762 ! mesenchymal cell differentiation [Term] id: GO:0014034 name: neural crest cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a neural crest cell." [GOC:dh, GOC:ef] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0014029 ! neural crest formation relationship: part_of GO:0014033 ! neural crest cell differentiation [Term] id: GO:0014035 name: neural crest cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dh, GOC:ef] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0014034 ! neural crest cell fate commitment [Term] id: GO:0014036 name: neural crest cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dh, GOC:ef] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0014034 ! neural crest cell fate commitment [Term] id: GO:0014037 name: Schwann cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0007422 ! peripheral nervous system development [Term] id: GO:0014038 name: regulation of Schwann cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] is_a: GO:0045685 ! regulation of glial cell differentiation relationship: regulates GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014039 name: negative regulation of Schwann cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "down regulation of Schwann cell differentiation" EXACT [] synonym: "down-regulation of Schwann cell differentiation" EXACT [] synonym: "downregulation of Schwann cell differentiation" EXACT [] synonym: "inhibition of Schwann cell differentiation" NARROW [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation relationship: negatively_regulates GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014040 name: positive regulation of Schwann cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "activation of Schwann cell differentiation" NARROW [] synonym: "stimulation of Schwann cell differentiation" NARROW [] synonym: "up regulation of Schwann cell differentiation" EXACT [] synonym: "up-regulation of Schwann cell differentiation" EXACT [] synonym: "upregulation of Schwann cell differentiation" EXACT [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation relationship: positively_regulates GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014041 name: regulation of neuron maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef] is_a: GO:0045664 ! regulation of neuron differentiation relationship: regulates GO:0042551 ! neuron maturation [Term] id: GO:0014042 name: positive regulation of neuron maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "activation of neuron maturation" NARROW [] synonym: "stimulation of neuron maturation" NARROW [] synonym: "up regulation of neuron maturation" EXACT [] synonym: "up-regulation of neuron maturation" EXACT [] synonym: "upregulation of neuron maturation" EXACT [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0042551 ! neuron maturation [Term] id: GO:0014043 name: negative regulation of neuron maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "down regulation of neuron maturation" EXACT [] synonym: "down-regulation of neuron maturation" EXACT [] synonym: "downregulation of neuron maturation" EXACT [] synonym: "inhibition of neuron maturation" NARROW [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0042551 ! neuron maturation [Term] id: GO:0014044 name: Schwann cell development namespace: biological_process def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014045 name: establishment of endothelial blood-brain barrier namespace: biological_process def: "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh, GOC:dph, GOC:sart] synonym: "establishment of endothelial BBB" EXACT [PMID:20080302] synonym: "establishment of endothelial blood/brain barrier" EXACT [] is_a: GO:0060856 ! establishment of blood-brain barrier is_a: GO:0061028 ! establishment of endothelial barrier relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0014046 name: dopamine secretion namespace: biological_process def: "The regulated release of dopamine by a cell or group of cells. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef] is_a: GO:0015872 ! dopamine transport is_a: GO:0023061 ! signal release is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0014047 name: glutamate secretion namespace: biological_process def: "The controlled release of glutamate by a cell or group of cells. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef] xref: Reactome:1252938 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1279872 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1298786 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1326441 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1352557 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1372784 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1392794 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1417271 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1450360 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1470899 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1482930 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1497007 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1514394 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:1537978 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:210500 "Glutamate Neurotransmitter Release Cycle" is_a: GO:0023061 ! signal release is_a: GO:0032940 ! secretion by cell [Term] id: GO:0014048 name: regulation of glutamate secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0051046 ! regulation of secretion is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0014047 ! glutamate secretion [Term] id: GO:0014049 name: positive regulation of glutamate secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "activation of glutamate secretion" NARROW [] synonym: "stimulation of glutamate secretion" NARROW [] synonym: "up regulation of glutamate secretion" EXACT [] synonym: "up-regulation of glutamate secretion" EXACT [] synonym: "upregulation of glutamate secretion" EXACT [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion relationship: positively_regulates GO:0014047 ! glutamate secretion [Term] id: GO:0014050 name: negative regulation of glutamate secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "down regulation of glutamate secretion" EXACT [] synonym: "down-regulation of glutamate secretion" EXACT [] synonym: "downregulation of glutamate secretion" EXACT [] synonym: "inhibition of glutamate secretion" NARROW [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion relationship: negatively_regulates GO:0014047 ! glutamate secretion [Term] id: GO:0014051 name: gamma-aminobutyric acid secretion namespace: biological_process def: "The regulated release of gamma-aminobutyric acid by a cell or group of cells. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef] synonym: "GABA secretion" EXACT [] is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0023061 ! signal release is_a: GO:0046903 ! secretion [Term] id: GO:0014052 name: regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "regulation of GABA secretion" EXACT [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0051046 ! regulation of secretion is_a: GO:0051955 ! regulation of amino acid transport relationship: regulates GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0014053 name: negative regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW [] synonym: "negative regulation of GABA secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051956 ! negative regulation of amino acid transport relationship: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0014054 name: positive regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "activation of gamma-aminobutyric acid secretion" NARROW [] synonym: "positive regulation of GABA secretion" EXACT [] synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW [] synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051957 ! positive regulation of amino acid transport relationship: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0014055 name: acetylcholine secretion namespace: biological_process def: "The regulated release of acetylcholine by a cell or group of cells. The acetylcholine is a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0015870 ! acetylcholine transport [Term] id: GO:0014056 name: regulation of acetylcholine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051952 ! regulation of amine transport relationship: regulates GO:0014055 ! acetylcholine secretion [Term] id: GO:0014057 name: positive regulation of acetylcholine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "activation of acetylcholine secretion" NARROW [] synonym: "stimulation of acetylcholine secretion" NARROW [] synonym: "up regulation of acetylcholine secretion" EXACT [] synonym: "up-regulation of acetylcholine secretion" EXACT [] synonym: "upregulation of acetylcholine secretion" EXACT [] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0014056 ! regulation of acetylcholine secretion is_a: GO:0051954 ! positive regulation of amine transport relationship: positively_regulates GO:0014055 ! acetylcholine secretion [Term] id: GO:0014058 name: negative regulation of acetylcholine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "down regulation of acetylcholine secretion" EXACT [] synonym: "down-regulation of acetylcholine secretion" EXACT [] synonym: "downregulation of acetylcholine secretion" EXACT [] synonym: "inhibition of acetylcholine secretion" NARROW [] is_a: GO:0014056 ! regulation of acetylcholine secretion is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051953 ! negative regulation of amine transport relationship: negatively_regulates GO:0014055 ! acetylcholine secretion [Term] id: GO:0014059 name: regulation of dopamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0050433 ! regulation of catecholamine secretion relationship: regulates GO:0014046 ! dopamine secretion [Term] id: GO:0014060 name: regulation of epinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." [GOC:ef] synonym: "regulation of adrenaline secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion relationship: regulates GO:0048242 ! epinephrine secretion [Term] id: GO:0014061 name: regulation of norepinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef] synonym: "regulation of noradrenaline secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion relationship: regulates GO:0048243 ! norepinephrine secretion [Term] id: GO:0014062 name: regulation of serotonin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0051046 ! regulation of secretion is_a: GO:0051952 ! regulation of amine transport is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0001820 ! serotonin secretion [Term] id: GO:0014063 name: negative regulation of serotonin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "down regulation of serotonin secretion" EXACT [] synonym: "down-regulation of serotonin secretion" EXACT [] synonym: "downregulation of serotonin secretion" EXACT [] synonym: "inhibition of serotonin secretion" NARROW [] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051953 ! negative regulation of amine transport relationship: negatively_regulates GO:0001820 ! serotonin secretion [Term] id: GO:0014064 name: positive regulation of serotonin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "activation of serotonin secretion" NARROW [] synonym: "stimulation of serotonin secretion" NARROW [] synonym: "up regulation of serotonin secretion" EXACT [] synonym: "up-regulation of serotonin secretion" EXACT [] synonym: "upregulation of serotonin secretion" EXACT [] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051954 ! positive regulation of amine transport relationship: positively_regulates GO:0001820 ! serotonin secretion [Term] id: GO:0014065 name: phosphatidylinositol 3-kinase cascade namespace: biological_process def: "A series of reactions, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions." [GOC:ef, http://www.biocarta.com, Wikipedia:PI3K] synonym: "phosphoinositide 3-kinase cascade" EXACT [GOC:curators] synonym: "PI 3-kinase cascade" EXACT [] synonym: "PI3K cascade" EXACT [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0014066 name: regulation of phosphatidylinositol 3-kinase cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] synonym: "regulation of phosphoinositide 3-kinase cascade" EXACT [GOC:curators] synonym: "regulation of PI 3-kinase cascade" RELATED [] synonym: "regulation of PI3K cascade" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0014065 ! phosphatidylinositol 3-kinase cascade [Term] id: GO:0014067 name: negative regulation of phosphatidylinositol 3-kinase cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] synonym: "down regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "down-regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "downregulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "inhibition of phosphatidylinositol 3-kinase cascade" NARROW [] synonym: "negative regulation of phosphoinositide 3-kinase cascade" EXACT [GOC:curators] synonym: "negative regulation of PI 3-kinase cascade" EXACT [] synonym: "negative regulation of PI3K cascade" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase cascade relationship: negatively_regulates GO:0014065 ! phosphatidylinositol 3-kinase cascade [Term] id: GO:0014068 name: positive regulation of phosphatidylinositol 3-kinase cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] synonym: "activation of phosphoinositide 3-kinase cascade" NARROW [] synonym: "positive regulation of phosphoinositide 3-kinase cascade" EXACT [GOC:curators] synonym: "positive regulation of PI 3-kinase cascade" EXACT [] synonym: "positive regulation of PI3K cascade" EXACT [] synonym: "stimulation of phosphatidylinositol 3-kinase cascade" NARROW [] synonym: "up regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "up-regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "upregulation of phosphatidylinositol 3-kinase cascade" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase cascade relationship: positively_regulates GO:0014065 ! phosphatidylinositol 3-kinase cascade [Term] id: GO:0014069 name: postsynaptic density namespace: cellular_component def: "The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases." [GOC:ef, GOC:jid, http://molneuro.kaist.ac.kr/psd, http://wikipedia.org/Postsynaptic_density, PMID:14532281] synonym: "post synaptic density" EXACT [] synonym: "post-synaptic density" EXACT [] xref: NIF_Subcellular:sao1196688972 xref: Wikipedia:Postsynaptic_density is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044456 ! synapse part [Term] id: GO:0014070 name: response to organic cyclic compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [CHEBI:33832, GOC:ef] synonym: "response to organic cyclic substance" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0014071 name: response to cycloalkane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [CHEBI:23453, GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0014072 name: response to isoquinoline alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [CHEBI:24921, GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0014073 name: response to tropane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [CHEBI:35615, GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0014074 name: response to purine-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [CHEBI:26401, GOC:ef] synonym: "response to purine" RELATED [GOC:curators] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0014075 name: response to amine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [CHEBI:32952, GOC:ef] is_a: GO:0010243 ! response to organic nitrogen [Term] id: GO:0014076 name: response to fluoxetine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [CHEBI:5118, GOC:ef] synonym: "response to selective serotonin reuptake inhibitor" RELATED [GOC:curators] synonym: "response to SSRI" RELATED [GOC:curators] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0014701 name: junctional sarcoplasmic reticulum membrane namespace: cellular_component def: "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] is_a: GO:0033017 ! sarcoplasmic reticulum membrane [Term] id: GO:0014702 name: free sarcoplasmic reticulum membrane namespace: cellular_component def: "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] is_a: GO:0033017 ! sarcoplasmic reticulum membrane [Term] id: GO:0014703 name: oscillatory muscle contraction namespace: biological_process def: "A process in which force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation." [GOC:mtg_muscle] is_a: GO:0003010 ! voluntary skeletal muscle contraction [Term] id: GO:0014704 name: intercalated disc namespace: cellular_component def: "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] synonym: "intercalated disk" EXACT [] xref: Wikipedia:Intercalated_disc is_a: GO:0044291 ! cell-cell contact zone [Term] id: GO:0014705 name: C zone namespace: cellular_component def: "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin." [GOC:mtg_muscle] is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0031672 ! A band [Term] id: GO:0014706 name: striated muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] is_a: GO:0060537 ! muscle tissue development [Term] id: GO:0014707 name: branchiomeric skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish." [GOC:mtg_muscle] is_a: GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0014708 name: regulation of somitomeric trunk muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development." [GOC:mtg_muscle] is_a: GO:0048641 ! regulation of skeletal muscle tissue development relationship: regulates GO:0002075 ! somitomeric trunk muscle development [Term] id: GO:0014709 name: positive regulation of somitomeric trunk muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014708 ! regulation of somitomeric trunk muscle development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development relationship: positively_regulates GO:0002075 ! somitomeric trunk muscle development [Term] id: GO:0014710 name: negative regulation of somitomeric trunk muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014708 ! regulation of somitomeric trunk muscle development is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development relationship: negatively_regulates GO:0002075 ! somitomeric trunk muscle development [Term] id: GO:0014711 name: regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0048641 ! regulation of skeletal muscle tissue development relationship: regulates GO:0014707 ! branchiomeric skeletal muscle development [Term] id: GO:0014712 name: positive regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development relationship: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development [Term] id: GO:0014713 name: negative regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development relationship: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development [Term] id: GO:0014714 name: myoblast cell fate commitment in head namespace: biological_process def: "The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0048625 ! myoblast cell fate commitment [Term] id: GO:0014715 name: myoblast cell fate commitment in trunk namespace: biological_process def: "The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0048625 ! myoblast cell fate commitment [Term] id: GO:0014716 name: satellite cell asymmetric division involved in skeletal muscle regeneration namespace: biological_process def: "Satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] is_a: GO:0014833 ! satellite cell asymmetric division relationship: part_of GO:0014834 ! satellite cell maintenance involved in skeletal muscle regeneration [Term] id: GO:0014717 name: regulation of satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0050865 ! regulation of cell activation relationship: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014718 name: positive regulation of satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration is_a: GO:0050867 ! positive regulation of cell activation relationship: part_of GO:0043415 ! positive regulation of skeletal muscle tissue regeneration relationship: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014719 name: satellite cell activation namespace: biological_process def: "A change in the morphology or behavior of a satellite cell resulting from exposure to an activating factor such as a cellular or soluble ligand. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] is_a: GO:0001775 ! cell activation [Term] id: GO:0014720 name: tonic skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue." [GOC:mtg_muscle] is_a: GO:0003010 ! voluntary skeletal muscle contraction [Term] id: GO:0014721 name: twitch skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation." [GOC:mtg_muscle] is_a: GO:0003010 ! voluntary skeletal muscle contraction [Term] id: GO:0014722 name: regulation of skeletal muscle contraction by calcium ion signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle contraction by calcium ion signalling" EXACT [] is_a: GO:0014819 ! regulation of skeletal muscle contraction is_a: GO:0019722 ! calcium-mediated signaling [Term] id: GO:0014723 name: regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril." [GOC:mtg_muscle] synonym: "regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction" EXACT [] is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling [Term] id: GO:0014724 name: regulation of twitch skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction relationship: regulates GO:0014721 ! twitch skeletal muscle contraction [Term] id: GO:0014725 name: regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0048641 ! regulation of skeletal muscle tissue development relationship: regulates GO:0002074 ! extraocular skeletal muscle development [Term] id: GO:0014726 name: negative regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014725 ! regulation of extraocular skeletal muscle development is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development relationship: negatively_regulates GO:0002074 ! extraocular skeletal muscle development [Term] id: GO:0014727 name: positive regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014725 ! regulation of extraocular skeletal muscle development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development relationship: positively_regulates GO:0002074 ! extraocular skeletal muscle development [Term] id: GO:0014728 name: regulation of the force of skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges." [GOC:mtg_muscle] is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion [Term] id: GO:0014729 name: regulation of the velocity of shortening of skeletal muscle modulating contraction namespace: biological_process def: "Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres." [GOC:mtg_muscle] synonym: "regulation of the velocity of shortening of skeletal muscle during contraction" RELATED [GOC:dph] is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0014730 name: skeletal muscle regeneration at neuromuscular junction namespace: biological_process def: "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers." [GOC:mtg_muscle] is_a: GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014731 name: spectrin-associated cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane." [GOC:mtg_muscle, PMID:15970557] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0014732 name: skeletal muscle atrophy namespace: biological_process def: "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] is_a: GO:0014891 ! striated muscle atrophy is_a: GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0014733 name: regulation of skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0014734 name: skeletal muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014897 ! striated muscle hypertrophy is_a: GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0014735 name: regulation of muscle atrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0014889 ! muscle atrophy [Term] id: GO:0014736 name: negative regulation of muscle atrophy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy." [GOC:mtg_muscle] is_a: GO:0014735 ! regulation of muscle atrophy is_a: GO:0014745 ! negative regulation of muscle adaptation relationship: negatively_regulates GO:0014889 ! muscle atrophy [Term] id: GO:0014737 name: positive regulation of muscle atrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] is_a: GO:0014735 ! regulation of muscle atrophy is_a: GO:0014744 ! positive regulation of muscle adaptation relationship: positively_regulates GO:0014889 ! muscle atrophy [Term] id: GO:0014738 name: regulation of muscle hyperplasia namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0014900 ! muscle hyperplasia [Term] id: GO:0014739 name: positive regulation of muscle hyperplasia namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] is_a: GO:0014738 ! regulation of muscle hyperplasia is_a: GO:0014744 ! positive regulation of muscle adaptation relationship: positively_regulates GO:0014900 ! muscle hyperplasia [Term] id: GO:0014740 name: negative regulation of muscle hyperplasia namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia." [GOC:mtg_muscle] is_a: GO:0014738 ! regulation of muscle hyperplasia is_a: GO:0014745 ! negative regulation of muscle adaptation relationship: negatively_regulates GO:0014900 ! muscle hyperplasia [Term] id: GO:0014741 name: negative regulation of muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0014896 ! muscle hypertrophy [Term] id: GO:0014742 name: positive regulation of muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0014896 ! muscle hypertrophy [Term] id: GO:0014743 name: regulation of muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0090257 ! regulation of muscle system process relationship: regulates GO:0014896 ! muscle hypertrophy [Term] id: GO:0014744 name: positive regulation of muscle adaptation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "positive regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0043500 ! muscle adaptation [Term] id: GO:0014745 name: negative regulation of muscle adaptation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "negative regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0043500 ! muscle adaptation [Term] id: GO:0014746 name: regulation of tonic skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction relationship: regulates GO:0014720 ! tonic skeletal muscle contraction [Term] id: GO:0014747 name: positive regulation of tonic skeletal muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction relationship: positively_regulates GO:0014720 ! tonic skeletal muscle contraction [Term] id: GO:0014748 name: negative regulation of tonic skeletal muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction relationship: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction [Term] id: GO:0014801 name: longitudinal sarcoplasmic reticulum namespace: cellular_component def: "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle] is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0014802 name: terminal cisterna namespace: cellular_component def: "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release." [GOC:mtg_muscle] xref: Wikipedia:Terminal_cisterna is_a: GO:0031984 ! organelle subcompartment is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0014803 name: longitudinal sarcoplasmic reticulum lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae." [GOC:mtg_muscle] is_a: GO:0033018 ! sarcoplasmic reticulum lumen relationship: part_of GO:0014801 ! longitudinal sarcoplasmic reticulum [Term] id: GO:0014804 name: terminal cisterna lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin." [GOC:mtg_muscle] is_a: GO:0033018 ! sarcoplasmic reticulum lumen relationship: part_of GO:0014802 ! terminal cisterna [Term] id: GO:0014805 name: smooth muscle adaptation namespace: biological_process def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "smooth muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014806 name: smooth muscle hyperplasia namespace: biological_process def: "A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation [Term] id: GO:0014807 name: regulation of somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0001756 ! somitogenesis [Term] id: GO:0014808 name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum namespace: biological_process def: "The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:mtg_muscle] synonym: "release of sequestered calcium ion by sarcoplasmic reticulum into cytosol" RELATED [GOC:dph, GOC:tb] is_a: GO:0051209 ! release of sequestered calcium ion into cytosol is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport [Term] id: GO:0014809 name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling [Term] id: GO:0014810 name: positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion is_a: GO:0045989 ! positive regulation of striated muscle contraction [Term] id: GO:0014811 name: negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion is_a: GO:0045988 ! negative regulation of striated muscle contraction [Term] id: GO:0014812 name: muscle cell migration namespace: biological_process def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle] is_a: GO:0016477 ! cell migration [Term] id: GO:0014813 name: satellite cell commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048865 ! stem cell fate commitment relationship: part_of GO:0014816 ! satellite cell differentiation [Term] id: GO:0014814 name: axon regeneration at neuromuscular junction namespace: biological_process def: "The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones." [GOC:ef, GOC:mtg_muscle] is_a: GO:0031103 ! axon regeneration [Term] id: GO:0014815 name: initiation of satellite cell activation by growth factor signalling, involved in skeletal muscle regeneration namespace: biological_process def: "Signalling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014718 ! positive regulation of satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014816 name: satellite cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048863 ! stem cell differentiation relationship: part_of GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0014817 name: satellite cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048866 ! stem cell fate specification relationship: part_of GO:0014813 ! satellite cell commitment [Term] id: GO:0014818 name: satellite cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048867 ! stem cell fate determination relationship: part_of GO:0014813 ! satellite cell commitment [Term] id: GO:0014819 name: regulation of skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0006942 ! regulation of striated muscle contraction relationship: regulates GO:0003009 ! skeletal muscle contraction [Term] id: GO:0014820 name: tonic smooth muscle contraction namespace: biological_process def: "A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction." [GOC:mtg_muscle] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014821 name: phasic smooth muscle contraction namespace: biological_process def: "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014822 name: detection of wounding namespace: biological_process def: "The series of events by which an injury stimulus is received and converted into a molecular signal." [GOC:mtg_muscle] synonym: "detection of injury" EXACT [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009611 ! response to wounding [Term] id: GO:0014823 name: response to activity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus." [GOC:mtg_muscle] synonym: "response to exercise" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0014824 name: artery smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MESH:A07.231.114] is_a: GO:0014820 ! tonic smooth muscle contraction is_a: GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0014825 name: stomach fundus smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch." [GOC:mtg_muscle, MA:0001612] is_a: GO:0014847 ! proximal stomach smooth muscle contraction [Term] id: GO:0014826 name: vein smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MESH:A07.231.908] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0014827 name: intestine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MESH:A03.556.124] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction [Term] id: GO:0014828 name: distal stomach smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus." [GOC:mtg_muscle, http://biology.about.com] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction [Term] id: GO:0014829 name: vascular smooth muscle contraction namespace: biological_process def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718] is_a: GO:0006939 ! smooth muscle contraction is_a: GO:0042310 ! vasoconstriction [Term] id: GO:0014830 name: arteriole smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries." [GOC:mtg_muscle, MA:0000706, MESH:A07.231.114.060] is_a: GO:0014824 ! artery smooth muscle contraction [Term] id: GO:0014831 name: gastro-intestinal system smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MESH:A03.556] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014832 name: urinary bladder smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mtg_muscle, MA:0001697, MESH:A05.810.890] is_a: GO:0014848 ! urinary tract smooth muscle contraction [Term] id: GO:0014833 name: satellite cell asymmetric division namespace: biological_process def: "The asymmetric division of a satellite cell that occurs when a satellite cell divides to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool. Satellite cells are quiescent adult muscle stem cells that become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0008356 ! asymmetric cell division relationship: part_of GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0014834 name: satellite cell maintenance involved in skeletal muscle regeneration namespace: biological_process def: "The process essential to maintain a ready source of satellite cells. It consists of the return of activated satellite cells to a quiescent state after proliferation to replenish the satellite cell pool. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:16607119] synonym: "satellite cell compartment self-renewal involved in skeletal muscle regeneration" EXACT [GOC:dph, GOC:tb] synonym: "satellite cell population maintenance" EXACT [] synonym: "satellite cell self-renewal" BROAD [] is_a: GO:0035019 ! somatic stem cell maintenance relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014835 name: myoblast cell differentiation involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast cell. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0045445 ! myoblast differentiation relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014836 name: myoblast cell fate commitment involved in skeletal muscle regeneration namespace: biological_process def: "The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast cell. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048625 ! myoblast cell fate commitment relationship: part_of GO:0014835 ! myoblast cell differentiation involved in skeletal muscle regeneration [Term] id: GO:0014837 name: myoblast cell fate determination involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0007518 ! myoblast cell fate determination relationship: part_of GO:0014836 ! myoblast cell fate commitment involved in skeletal muscle regeneration [Term] id: GO:0014838 name: myoblast cell fate specification involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048626 ! myoblast cell fate specification relationship: part_of GO:0014836 ! myoblast cell fate commitment involved in skeletal muscle regeneration [Term] id: GO:0014839 name: myoblast migration involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] synonym: "mononucleate cell migration involved in skeletal muscle regeneration" BROAD [] is_a: GO:0051451 ! myoblast migration relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014841 name: satellite cell proliferation namespace: biological_process def: "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0014842 name: regulation of satellite cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0014841 ! satellite cell proliferation [Term] id: GO:0014843 name: growth factor dependent regulation of satellite cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014842 ! regulation of satellite cell proliferation [Term] id: GO:0014844 name: myoblast cell proliferation involved in skeletal muscle regeneration namespace: biological_process def: "The multiplication or reproduction of myoblast cells, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0051450 ! myoblast proliferation relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014845 name: stomach body smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined." [GOC:ef, GOC:mtg_muscle, MA:0002559] is_a: GO:0014828 ! distal stomach smooth muscle contraction [Term] id: GO:0014846 name: esophagus smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract." [GOC:ef, GOC:mtg_muscle, MA:0001573, MESH:A03.556.875.500] synonym: "oesophagus smooth muscle contraction" RELATED [GOC:dph] is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction [Term] id: GO:0014847 name: proximal stomach smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach." [GOC:mtg_muscle, http://biology.about.com] is_a: GO:0014820 ! tonic smooth muscle contraction is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction [Term] id: GO:0014848 name: urinary tract smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, MA:0000325, MESH:A05.810] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014849 name: ureter smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014848 ! urinary tract smooth muscle contraction [Term] id: GO:0014850 name: response to muscle activity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus." [GOC:mtg_muscle] is_a: GO:0014823 ! response to activity [Term] id: GO:0014852 name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014853 name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction namespace: biological_process def: "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle] is_a: GO:0060079 ! regulation of excitatory postsynaptic membrane potential relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014854 name: response to inactivity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus." [GOC:mtg_muscle] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0014855 name: striated muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle] is_a: GO:0033002 ! muscle cell proliferation [Term] id: GO:0014856 name: skeletal muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0014855 ! striated muscle cell proliferation [Term] id: GO:0014857 name: regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014858 name: positive regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation relationship: positively_regulates GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014859 name: negative regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation relationship: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014860 name: neurotransmitter secretion involved in regulation of skeletal muscle contraction namespace: biological_process def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb] synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0007269 ! neurotransmitter secretion relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014861 name: regulation of skeletal muscle contraction via membrane action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014862 name: regulation of skeletal muscle contraction by chemo-mechanical energy conversion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014863 name: detection of inactivity namespace: biological_process def: "The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014854 ! response to inactivity is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0014864 name: detection of muscle activity namespace: biological_process def: "The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014850 ! response to muscle activity is_a: GO:0014865 ! detection of activity [Term] id: GO:0014865 name: detection of activity namespace: biological_process def: "The series of events in which an activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014823 ! response to activity is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0014866 name: skeletal myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] is_a: GO:0030239 ! myofibril assembly [Term] id: GO:0014868 name: cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "A process in which cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction [Term] id: GO:0014869 name: detection of muscle inactivity namespace: biological_process def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014863 ! detection of inactivity is_a: GO:0014870 ! response to muscle inactivity [Term] id: GO:0014870 name: response to muscle inactivity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus." [GOC:mtg_muscle] is_a: GO:0014854 ! response to inactivity [Term] id: GO:0014871 name: cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "The process in which actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction [Term] id: GO:0014872 name: myoblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle] is_a: GO:0051301 ! cell division [Term] id: GO:0014873 name: response to muscle activity involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to fatigue" EXACT [] synonym: "response to muscle activity involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014850 ! response to muscle activity is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation [Term] id: GO:0014874 name: response to stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0050896 ! response to stimulus relationship: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014875 name: detection of muscle activity involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "detection of fatigue" EXACT [] is_a: GO:0014864 ! detection of muscle activity is_a: GO:0014873 ! response to muscle activity involved in regulation of muscle adaptation [Term] id: GO:0014876 name: response to injury involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to injury involved in regulation of muscle plasticity" RELATED [] is_a: GO:0009611 ! response to wounding is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation [Term] id: GO:0014877 name: response to muscle inactivity involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014870 ! response to muscle inactivity is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation [Term] id: GO:0014878 name: response to electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation is_a: GO:0051602 ! response to electrical stimulus [Term] id: GO:0014879 name: detection of electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation is_a: GO:0050981 ! detection of electrical stimulus [Term] id: GO:0014880 name: regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] is_a: GO:0032971 ! regulation of muscle filament sliding relationship: part_of GO:0014729 ! regulation of the velocity of shortening of skeletal muscle modulating contraction [Term] id: GO:0014881 name: regulation of myofibril size namespace: biological_process def: "Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] synonym: "change of myofibril size" EXACT [] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0090066 ! regulation of anatomical structure size [Term] id: GO:0014882 name: regulation of myofibril number namespace: biological_process def: "Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] synonym: "change of myofibril number" EXACT [] is_a: GO:0014738 ! regulation of muscle hyperplasia is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0014883 name: transition between fast and slow fiber namespace: biological_process def: "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] synonym: "transition between fast and slow fibre" EXACT [] synonym: "transition fast-slow fiber" EXACT [] synonym: "transition fast-slow fibre" EXACT [] is_a: GO:0014733 ! regulation of skeletal muscle adaptation [Term] id: GO:0014884 name: detection of muscle inactivity involved in regulation of muscle adaptation namespace: biological_process def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014869 ! detection of muscle inactivity is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation [Term] id: GO:0014885 name: detection of injury involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "detection of injury involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014822 ! detection of wounding is_a: GO:0014876 ! response to injury involved in regulation of muscle adaptation [Term] id: GO:0014886 name: transition between slow and fast fiber namespace: biological_process def: "The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] synonym: "transition between slow and fast fibre" EXACT [] synonym: "transition slow-fast fiber" EXACT [] synonym: "transition slow-fast fibre" EXACT [] is_a: GO:0014733 ! regulation of skeletal muscle adaptation [Term] id: GO:0014887 name: cardiac muscle adaptation namespace: biological_process def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] synonym: "cardiac muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation [Term] id: GO:0014888 name: striated muscle adaptation namespace: biological_process def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "striated muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014889 name: muscle atrophy namespace: biological_process def: "A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] xref: Wikipedia:Muscle_atrophy is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014890 name: smooth muscle atrophy namespace: biological_process def: "A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014889 ! muscle atrophy [Term] id: GO:0014891 name: striated muscle atrophy namespace: biological_process def: "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] is_a: GO:0014888 ! striated muscle adaptation is_a: GO:0014889 ! muscle atrophy [Term] id: GO:0014893 name: response to rest involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation [Term] id: GO:0014894 name: response to denervation involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation [Term] id: GO:0014895 name: smooth muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0014896 name: muscle hypertrophy namespace: biological_process def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle] xref: Wikipedia:Muscle_hypertrophy is_a: GO:0003012 ! muscle system process [Term] id: GO:0014897 name: striated muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0014898 name: cardiac muscle hypertrophy in response to stress namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:mtg_muscle] is_a: GO:0003299 ! muscle hypertrophy in response to stress is_a: GO:0003300 ! cardiac muscle hypertrophy is_a: GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0014899 name: cardiac muscle atrophy namespace: biological_process def: "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle] is_a: GO:0014887 ! cardiac muscle adaptation is_a: GO:0014891 ! striated muscle atrophy [Term] id: GO:0014900 name: muscle hyperplasia namespace: biological_process def: "A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle] is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014901 name: satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "The process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] is_a: GO:0014719 ! satellite cell activation relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014902 name: myotube differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0014904 name: myotube cell development namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0048468 ! cell development relationship: part_of GO:0014902 ! myotube differentiation [Term] id: GO:0014905 name: myoblast fusion involved in skeletal muscle regeneration namespace: biological_process def: "A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0007520 ! myoblast fusion relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration [Term] id: GO:0014906 name: myotube cell development involved in skeletal muscle regeneration namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0014904 ! myotube cell development relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration [Term] id: GO:0014908 name: myotube differentiation involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0014902 ! myotube differentiation relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014909 name: smooth muscle cell migration namespace: biological_process def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014812 ! muscle cell migration [Term] id: GO:0014910 name: regulation of smooth muscle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0014909 ! smooth muscle cell migration [Term] id: GO:0014911 name: positive regulation of smooth muscle cell migration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030335 ! positive regulation of cell migration relationship: positively_regulates GO:0014909 ! smooth muscle cell migration [Term] id: GO:0014912 name: negative regulation of smooth muscle cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030336 ! negative regulation of cell migration relationship: negatively_regulates GO:0014909 ! smooth muscle cell migration [Term] id: GO:0014914 name: myoblast maturation involved in muscle regeneration namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0048628 ! myoblast maturation [Term] id: GO:0014915 name: regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction is_a: GO:0032972 ! regulation of muscle filament sliding speed [Term] id: GO:0014916 name: regulation of lung blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] synonym: "regulation of pulmonary blood pressure" EXACT [] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0014917 name: positive regulation of diuresis by pressure natriuresis namespace: biological_process def: "OBSOLETE. The process in which pressure natriuresis increases the rate of diuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true replaced_by: GO:0035818 [Term] id: GO:0014918 name: positive regulation of natriuresis by pressure natriuresis namespace: biological_process def: "OBSOLETE. The process in which pressure natriuresis increases rate of natriuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true replaced_by: GO:0035819 [Term] id: GO:0015000 name: polyferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015001 name: high-potential iron-sulfur carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "high-potential iron-sulphur carrier" EXACT [] synonym: "HiPIP" RELATED [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015002 name: heme-copper terminal oxidase activity namespace: molecular_function def: "Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd] subset: gosubset_prok synonym: "haem-copper terminal oxidase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0015003 name: copper electron carrier namespace: molecular_function def: "OBSOLETE. A copper-containing entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015004 name: small blue copper electron carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015005 name: azurin namespace: molecular_function def: "OBSOLETE. Brilliant blue copper-containing protein of low molecular weight found in some bacteria; thought to transfer electrons to cytochrome oxidase. This definition includes pseudoazurin." [ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0009055 [Term] id: GO:0015006 name: plastocyanin namespace: molecular_function def: "OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I." [ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true replaced_by: GO:0046028 [Term] id: GO:0015007 name: electron carrier, chlorophyll electron transport system namespace: molecular_function def: "OBSOLETE. A molecular entity that serves as an electron acceptor and electron donor in a chlorophyll electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it contains both process and function information. synonym: "chlorophyll electron carrier" RELATED [] is_obsolete: true consider: GO:0009055 consider: GO:0009767 [Term] id: GO:0015009 name: corrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "corrin metabolism" EXACT [] is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0015010 name: tetrahydrocorphin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins." [http://findarticles.com/p/articles/mi_m0841/is_n1_v28/ai_13746418, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44] subset: gosubset_prok synonym: "tetrahydrocorphin metabolism" EXACT [] is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0015011 name: nickel-tetrapyrrole coenzyme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44, http://www.chem.qmul.ac.uk/iupac/bioinorg/EG.html#33] subset: gosubset_prok synonym: "coenzyme F430 metabolic process" NARROW [] synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0015010 ! tetrahydrocorphin metabolic process [Term] id: GO:0015012 name: heparan sulfate proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0198547684, RESID:AA0210] subset: gosubset_prok synonym: "heparan sulfate proteoglycan anabolism" EXACT [] synonym: "heparan sulfate proteoglycan biosynthesis" EXACT [] synonym: "heparan sulfate proteoglycan formation" EXACT [] synonym: "heparan sulfate proteoglycan synthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthetic process" EXACT [] synonym: "heparin proteoglycan biosynthetic process" RELATED [] xref: RESID:AA0210 is_a: GO:0030166 ! proteoglycan biosynthetic process is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0015013 name: heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide namespace: biological_process def: "The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan." [ISBN:0815316194] subset: gosubset_prok synonym: "heparan sulfate proteoglycan anabolism, linkage to polypeptide" EXACT [] synonym: "heparan sulfate proteoglycan formation, linkage to polypeptide" EXACT [] synonym: "heparan sulfate proteoglycan synthesis, linkage to polypeptide" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, linkage to polypeptide" EXACT [] synonym: "heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide" EXACT [] synonym: "heparin proteoglycan biosynthetic process, linkage to polypeptide" RELATED [] is_a: GO:0018242 ! protein O-linked glycosylation via serine is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0015014 name: heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai] subset: gosubset_prok synonym: "heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] synonym: "heparan sulfate proteoglycan chain elongation" EXACT [] synonym: "heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] synonym: "heparan sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] synonym: "heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] synonym: "heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" RELATED [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0015015 name: heparan sulfate proteoglycan biosynthetic process, enzymatic modification namespace: biological_process def: "The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization." [ISBN:0815316194] subset: gosubset_prok synonym: "heparan sulfate proteoglycan anabolism, enzymatic modification" EXACT [] synonym: "heparan sulfate proteoglycan formation, enzymatic modification" EXACT [] synonym: "heparan sulfate proteoglycan synthesis, enzymatic modification" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, enzymatic modification" EXACT [] synonym: "heparan sulphate proteoglycan biosynthetic process, enzymatic modification" EXACT [] synonym: "heparin proteoglycan biosynthetic process, enzymatic modification" RELATED [] is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0015016 name: [heparan sulfate]-glucosamine N-sulfotransferase activity namespace: molecular_function alt_id: GO:0004393 alt_id: GO:0015022 alt_id: GO:0051910 def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine." [EC:2.8.2.8] comment: Note that this activity includes EC:2.8.2.12 (deleted from EC). synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT [] synonym: "desulfoheparin sulfotransferase activity" EXACT [] synonym: "glucosaminyl N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate 2-N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparin N-deacetylase/N-sulfotransferase activity" RELATED [] synonym: "heparin N-deacetylase/N-sulphotransferase activity" RELATED [] synonym: "heparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparin-glucosamine N-sulfotransferase activity" EXACT [] synonym: "heparitin N-sulfotransferase activity" EXACT [] synonym: "heparitin N-sulphotransferase activity" EXACT [] synonym: "heparitin sulfotransferase activity" EXACT [] synonym: "N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "N-heparan sulfate sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "N-HSST activity" EXACT [EC:2.8.2.8] synonym: "PAPS:DSH sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "PAPS:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] xref: EC:2.8.2.8 xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0015017 name: glypican namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product (was misspelled 'glycipan'). is_obsolete: true [Term] id: GO:0015018 name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135] synonym: "glucuronosyltransferase I activity" NARROW [EC:2.4.1.135] synonym: "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] synonym: "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] synonym: "uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity" EXACT [EC:2.4.1.135] xref: EC:2.4.1.135 xref: MetaCyc:2.4.1.135-RXN is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0015019 name: heparan-alpha-glucosaminide N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide." [EC:2.3.1.78] synonym: "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] synonym: "acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] synonym: "heparin-alpha-glucosaminide N-acetyltransferase activity" RELATED [] xref: EC:2.3.1.78 xref: MetaCyc:2.3.1.78-RXN is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0015020 name: glucuronosyltransferase activity namespace: molecular_function alt_id: GO:0003981 def: "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] synonym: "1-naphthol glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "1-naphthol-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "17-OH steroid UDPGT activity" NARROW [EC:2.4.1.17] synonym: "17beta-hydroxysteroid UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "3-OH androgenic UDPGT activity" NARROW [EC:2.4.1.17] synonym: "3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-nitrophenol UDPGT activity" NARROW [EC:2.4.1.17] synonym: "bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin monoglucuronide glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin UDPGT activity" NARROW [EC:2.4.1.17] synonym: "bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "ciramadol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "estriol UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "estrone UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "GT activity" EXACT [EC:2.4.1.17] synonym: "morphine glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenylglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-phenylphenol glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "phenyl-UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "Phenyl-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "PNP-UDPGT" RELATED [EC:2.4.1.17] synonym: "pnp-UDPGT activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronic acid transferase activity" EXACT [EC:2.4.1.17] synonym: "UDP glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDPGA transferase activity" EXACT [EC:2.4.1.17] synonym: "UDPGA-glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" EXACT [EC:2.4.1.17] synonym: "UDPGT activity" EXACT [EC:2.4.1.17] synonym: "uridine 5'-diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphate glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] xref: EC:2.4.1.17 xref: MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN xref: Reactome:9978 "glucuronosyltransferase activity" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0015021 name: heparin-sulfate lyase activity namespace: molecular_function def: "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar." [EC:4.2.2.8] subset: gosubset_prok synonym: "[heparan sulfate]-sulfate lyase activity" RELATED [] synonym: "heparin-sulfate eliminase activity" RELATED [EC:4.2.2.8] synonym: "heparin-sulphate lyase activity" EXACT [] synonym: "heparitin-sulfate lyase activity" EXACT [] synonym: "heparitinase I" RELATED [EC:4.2.2.8] synonym: "heparitinase II" RELATED [EC:4.2.2.8] xref: EC:4.2.2.8 xref: MetaCyc:4.2.2.8-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0015023 name: syndecan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0015024 name: glucuronate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate." [EC:3.1.6.18] synonym: "chondro-2-sulfatase activity" EXACT [EC:3.1.6.18] synonym: "glucuronate-2-sulphatase activity" EXACT [] synonym: "glucurono-2-sulfatase activity" EXACT [EC:3.1.6.18] synonym: "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity" EXACT [EC:3.1.6.18] xref: EC:3.1.6.18 xref: MetaCyc:3.1.6.18-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0015025 name: GPI-anchored membrane-bound receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true replaced_by: GO:0031225 consider: GO:0004872 [Term] id: GO:0015026 name: coreceptor activity namespace: molecular_function alt_id: GO:0015027 alt_id: GO:0015028 def: "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators] synonym: "coreceptor, insoluble ligand activity" RELATED [GOC:mah] synonym: "coreceptor, soluble ligand activity" RELATED [GOC:mah] is_a: GO:0004872 ! receptor activity [Term] id: GO:0015029 name: internalization receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because internalization is a process, not a ligand to which a receptor might bind. is_obsolete: true [Term] id: GO:0015030 name: Cajal body namespace: cellular_component def: "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [http://genetics.cwru.edu/matera3.html, PMID:10944589, PMID:11031238, PMID:7559785] synonym: "coiled body" EXACT [] synonym: "Gems" EXACT [] xref: Wikipedia:Cajal_body is_a: GO:0016604 ! nuclear body [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "enzyme transport" NARROW [] is_a: GO:0006810 ! transport is_a: GO:0045184 ! establishment of protein localization [Term] id: GO:0015032 name: storage protein import into fat body namespace: biological_process def: "The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life." [GOC:bf, PMID:10231363] synonym: "fat body metabolic process" BROAD [] synonym: "fat body metabolism" BROAD [] synonym: "fat body storage protein uptake" EXACT [] synonym: "import of storage protein into fat body" EXACT [] synonym: "storage protein import by fat body cells" EXACT [] synonym: "storage protein import into fat body cells" EXACT [] synonym: "storage protein transport into fat body cells" EXACT [] synonym: "storage protein uptake into fat body cells" EXACT [] is_a: GO:0017038 ! protein import [Term] id: GO:0015034 name: cytochrome P450 activity namespace: molecular_function def: "OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer." [ISBN:0198547684, PMID:1655423] comment: This term was made obsolete because it is a grouping term representing a set of gene products. is_obsolete: true consider: GO:0019825 [Term] id: GO:0015035 name: protein disulfide oxidoreductase activity namespace: molecular_function alt_id: GO:0008895 def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] subset: gosubset_prok synonym: "haem lyase disulphide oxidoreductase activity" NARROW [] synonym: "heme lyase disulfide oxidoreductase activity" NARROW [] synonym: "protein disulphide oxidoreductase activity" EXACT [] synonym: "thioredoxin activity" NARROW [GOC:mah, GOC:vw] xref: MetaCyc:DISULFOXRED-RXN is_a: GO:0015036 ! disulfide oxidoreductase activity [Term] id: GO:0015036 name: disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction that interconverts reduced sulfide groups and oxidized disulfide bonds in a substrate." [GOC:mah, MetaCyc:DISULFOXRED-RXN] subset: gosubset_prok synonym: "disulphide oxidoreductase activity" EXACT [] xref: Reactome:10513 "disulfide oxidoreductase activity" is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0015037 name: peptide disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds." [GOC:mah, MetaCyc:DISULFOXRED-RXN] subset: gosubset_prok synonym: "peptide disulphide oxidoreductase activity" EXACT [] is_a: GO:0015036 ! disulfide oxidoreductase activity [Term] id: GO:0015038 name: glutathione disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah] subset: gosubset_prok synonym: "glutaredoxin" RELATED [] synonym: "glutathione disulphide oxidoreductase activity" EXACT [] xref: Reactome:10509 "glutathione disulfide oxidoreductase activity" is_a: GO:0015037 ! peptide disulfide oxidoreductase activity [Term] id: GO:0015039 name: NADPH-adrenodoxin reductase activity namespace: molecular_function def: "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+." [EC:1.18.1.2, GOC:kd] comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'. synonym: "adrenodoxin reductase activity" BROAD [EC:1.18.1.2] synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd] synonym: "NADPH:adrenodoxin oxidoreductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.- is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0015040 name: electron transfer flavoprotein, group I namespace: molecular_function def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that links acyl-CoA dehydrogenase reactions with the respiratory chain, such as in the fatty acid degradation pathway." [PMID:8599534] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015041 name: electron transfer flavoprotein, group II namespace: molecular_function def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that is synthesized only under certain specific growth conditions and receives electrons from the oxidation of specific substrates, e.g. trimethylamine, carnitine and in nitrogen fixation." [PMID:8599534] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015042 name: trypanothione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide." [EC:1.8.1.12] comment: Note that this function was formerly EC:1.6.4.8. synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] synonym: "N1,N8-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] synonym: "NADPH2:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] synonym: "NADPH:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] synonym: "trypanothione reductase activity" EXACT [] synonym: "trypanothione-disulphide reductase activity" EXACT [] synonym: "trypanothione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.12] xref: EC:1.8.1.12 xref: MetaCyc:1.8.1.12-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0015043 name: leghemoglobin reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin." [EC:1.6.2.6] synonym: "ferric leghemoglobin reductase activity" EXACT [EC:1.6.2.6] synonym: "NAD(P)H:ferrileghemoglobin oxidoreductase activity" EXACT [EC:1.6.2.6] xref: EC:1.6.2.6 xref: MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: GO:0015044 name: rubredoxin-NAD+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1] subset: gosubset_prok synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "DPNH-rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "NADH--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] synonym: "NADH--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "NADH:rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] synonym: "NADH:rubredoxin reductase activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin--NAD reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.1] xref: EC:1.18.1.1 xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0015045 name: rubredoxin-NAD(P)+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.4] synonym: "dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.4] synonym: "NAD(P)--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] synonym: "NAD(P)H--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] synonym: "NADPH:rubredoxin reductase activity" EXACT [] synonym: "rubredoxin--nicotinamide adenine activity" RELATED [EC:1.18.1.4] synonym: "rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity" EXACT [EC:1.18.1.4] synonym: "rubredoxin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.18.1.4] xref: EC:1.18.1.4 xref: MetaCyc:RUBREDOXIN--NADP+-REDUCTASE-RXN is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0015046 name: rubredoxin-NADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [EC:1.18.1.-] subset: gosubset_prok xref: EC:1.18.1.- is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0015047 name: NADPH-cytochrome-c2 reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2." [EC:1.6.2.5] synonym: "cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)" EXACT [EC:1.6.2.5] synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" EXACT [EC:1.6.2.5] synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.6.2.5] xref: EC:1.6.2.5 xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: GO:0015048 name: phthalate dioxygenase reductase activity namespace: molecular_function def: "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems." [PMID:7589982] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0015049 name: methane monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O." [EC:1.14.13.25] subset: gosubset_prok synonym: "methane hydroxylase activity" EXACT [EC:1.14.13.25] synonym: "methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.25] xref: EC:1.14.13.25 xref: MetaCyc:METHANE-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0007 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0015050 name: methane monooxygenase complex namespace: cellular_component def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [BRENDA:1.14.13.25, GOC:mah] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0015051 name: X-opioid receptor activity namespace: molecular_function def: "Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors." [InterPro:IPR001420] is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0015052 name: beta3-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta3 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0015053 name: opsin namespace: molecular_function def: "OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin." [ISBN:0198547684] comment: This term was made obsolete because it refers to a class of proteins. is_obsolete: true consider: GO:0007602 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015054 name: gastrin receptor activity namespace: molecular_function def: "Combining with gastrin to initiate a change in cell activity." [GOC:ai] synonym: "cholecystokinin-B receptor activity" EXACT [] is_a: GO:0004951 ! cholecystokinin receptor activity [Term] id: GO:0015055 name: secretin receptor activity namespace: molecular_function def: "Combining with secretin to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0015056 name: corticotrophin-releasing factor receptor activity namespace: molecular_function def: "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity." [PMID:12032352] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0015057 name: thrombin receptor activity namespace: molecular_function alt_id: GO:0010655 def: "Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [GOC:ai] synonym: "thrombin receptor activity, G-protein coupled" EXACT [] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0015058 name: epidermal growth factor-like module containing hormone receptor activity namespace: molecular_function alt_id: GO:0016523 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "EGF-like module containing hormone receptor activity" EXACT [] synonym: "Egr1 hormone receptor" EXACT [] is_obsolete: true [Term] id: GO:0015059 name: blue-sensitive opsin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. is_obsolete: true consider: GO:0007603 consider: GO:0009588 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015060 name: green-sensitive opsin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. is_obsolete: true consider: GO:0007603 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015061 name: red-sensitive opsin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. is_obsolete: true consider: GO:0007603 consider: GO:0009585 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015062 name: violet-sensitive opsin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. is_obsolete: true consider: GO:0007603 consider: GO:0009588 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015063 name: long-wave-sensitive opsin namespace: molecular_function def: "OBSOLETE. An opsin with maximal absorption above 500 nm." [PMID:10594055] comment: This term was made obsolete because it refers to a class of proteins. is_obsolete: true consider: GO:0007603 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015064 name: UV-sensitive opsin namespace: molecular_function def: "OBSOLETE. An opsin with maximal absorption below 400 nm." [PMID:10594055] comment: This term was made obsolete because it refers to a class of proteins. is_obsolete: true consider: GO:0007604 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015065 name: uridine nucleotide receptor activity namespace: molecular_function def: "Combining with UTP or UDP to initiate a change in cell activity." [GOC:curators, PMID:8537335] synonym: "purinoceptor type U" EXACT [] is_a: GO:0071553 ! pyrimidinergic nucleotide receptor activity, G-protein coupled [Term] id: GO:0015066 name: alpha-amylase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of alpha-amylase." [GOC:mah] subset: gosubset_prok is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0015067 name: amidinotransferase activity namespace: molecular_function def: "Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai] subset: gosubset_prok synonym: "transamidinase activity" EXACT [] xref: EC:2.1.4.- is_a: GO:0016741 ! transferase activity, transferring one-carbon groups is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0015068 name: glycine amidinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate." [EC:2.1.4.1] subset: gosubset_prok synonym: "arginine-glycine amidinotransferase activity" EXACT [EC:2.1.4.1] synonym: "arginine-glycine transamidinase activity" EXACT [EC:2.1.4.1] synonym: "glycine transamidinase activity" EXACT [EC:2.1.4.1] synonym: "L-arginine:glycine amidinotransferase activity" EXACT [EC:2.1.4.1] xref: EC:2.1.4.1 xref: MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN xref: Reactome:19902 "glycine amidinotransferase activity" is_a: GO:0015067 ! amidinotransferase activity [Term] id: GO:0015069 name: scyllo-inosamine-4-phosphate amidinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine." [EC:2.1.4.2, RHEA:13268] subset: gosubset_prok synonym: "inosamine-P amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "inosamine-phosphate amidinotransferase activity" EXACT [] synonym: "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "L-arginine:inosamine phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "L-arginine:inosamine-P-amidinotransferase activity" EXACT [EC:2.1.4.2] xref: EC:2.1.4.2 xref: KEGG:R03477 xref: MetaCyc:2.1.4.2-RXN xref: RHEA:13268 is_a: GO:0015067 ! amidinotransferase activity [Term] id: GO:0015070 name: toxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause injury to other living organisms." [GOC:jl] comment: This term was made obsolete because it represents a classification of molecules and not a molecular function. is_obsolete: true consider: GO:0009405 consider: GO:0050827 [Term] id: GO:0015072 name: phosphatidylinositol 3-kinase, class I, catalyst activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0016303 replaced_by: GO:0035005 replaced_by: GO:0046934 [Term] id: GO:0015073 name: phosphatidylinositol 3-kinase, class I, regulator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0046935 [Term] id: GO:0015074 name: DNA integration namespace: biological_process def: "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] subset: goslim_pir subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0015075 name: ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "ion transporter activity" EXACT [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0015076 name: heavy metal ion transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0046873 [Term] id: GO:0015077 name: monovalent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0015078 name: hydrogen ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "proton transporter activity" EXACT [] xref: Reactome:1383 "hydrogen ion transmembrane transporter activity" is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity [Term] id: GO:0015079 name: potassium ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0022817 def: "Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "potassium transporter activity" EXACT [] is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0015080 name: silver ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of silver (Ag) ions from one side of a membrane to the other." [GOC:ai] synonym: "silver transporter activity" EXACT [] is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015081 name: sodium ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0022816 def: "Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "sodium transporter activity" EXACT [] is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0015083 name: aluminum ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0015084 def: "Catalysis of the transfer of aluminum (Al) ions from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "aluminium ion transporter activity" EXACT [] synonym: "aluminium resistance permease activity" EXACT [] synonym: "aluminum resistance permease activity" EXACT [] is_a: GO:0046873 ! metal ion transmembrane transporter activity is_a: GO:0072510 ! trivalent inorganic cation transmembrane transporter activity [Term] id: GO:0015085 name: calcium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf] subset: gosubset_prok is_a: GO:0046873 ! metal ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015086 name: cadmium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cadmium (Cd) ions from one side of a membrane to the other." [GOC:dgf] subset: gosubset_prok synonym: "zinc, cadmium uptake permease activity" RELATED [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] is_a: GO:0046915 ! transition metal ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015087 name: cobalt ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other." [GOC:dgf] subset: gosubset_prok synonym: "cobalt, zinc uptake permease activity" RELATED [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015088 name: copper uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in)." [TC:9.A.12.-.-] is_a: GO:0005375 ! copper ion transmembrane transporter activity [Term] id: GO:0015089 name: high affinity copper ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu2+(out) = Cu2+(in)." [TC:9.A.11.1.1] synonym: "high affinity copper transporter activity" EXACT [] is_a: GO:0005375 ! copper ion transmembrane transporter activity [Term] id: GO:0015090 name: low affinity iron ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in)." [TC:9.A.9.1.1] synonym: "low affinity iron transporter activity" EXACT [] is_a: GO:0005381 ! iron ion transmembrane transporter activity [Term] id: GO:0015091 name: ferric iron transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0005381 ! iron ion transmembrane transporter activity is_a: GO:0072510 ! trivalent inorganic cation transmembrane transporter activity [Term] id: GO:0015092 name: high affinity ferric uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of Fe(III) from the outside of a cell to the inside of a cell across a membrane." [GOC:ai, TC:9.A.10.1.1] is_a: GO:0015091 ! ferric iron transmembrane transporter activity [Term] id: GO:0015093 name: ferrous iron transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0005381 ! iron ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015094 name: lead ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lead (Pb) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] is_a: GO:0046873 ! metal ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015095 name: magnesium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf] subset: gosubset_prok xref: Reactome:20101 "magnesium ion transmembrane transporter activity" is_a: GO:0046873 ! metal ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015096 name: manganese resistance permease activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because the term is undefined and we don't know the mechanism so we can't make a correct definition. is_obsolete: true [Term] id: GO:0015097 name: mercury ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0046915 ! transition metal ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015098 name: molybdate ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "molybdate transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015099 name: nickel ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nickel (Ni) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015100 name: vanadium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of vanadium (V) ions from one side of a membrane to the other." [GOC:ai] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015101 name: organic cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: Reactome:14028 "organic cation transmembrane transporter activity" is_a: GO:0008324 ! cation transmembrane transporter activity [Term] id: GO:0015103 name: inorganic anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai] subset: gosubset_prok is_a: GO:0008509 ! anion transmembrane transporter activity [Term] id: GO:0015104 name: antimonite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of antimonite from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015105 name: arsenite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arsenite from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015106 name: bicarbonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015107 name: chlorate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of chlorate, ClO3-, from one side of a membrane to the other." [CHEBI:49709, GOC:curators] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015108 name: chloride transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of chloride ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015109 name: chromate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3." [GOC:ai] subset: gosubset_prok is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015110 name: cyanate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015111 name: iodide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of iodide ions from one side of a membrane to the other." [GOC:ai] xref: Reactome:20767 "iodide transmembrane transporter activity" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015112 name: nitrate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrate ions (NO3-) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "nitrite/nitrate porter activity" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015113 name: nitrite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrite (NO2-) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "nitrite/nitrate porter activity" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015114 name: phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015115 name: silicate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [CHEBI:48123, GOC:ai] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015116 name: sulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "sulfate permease activity" RELATED [] synonym: "sulphate transporter activity" EXACT [] xref: Reactome:3205 "sulfate transmembrane transporter activity" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015117 name: thiosulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "thiosulfate permease activity" RELATED [] synonym: "thiosulphate transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015118 name: tellurite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals." [CHEBI:30477, GOC:ai] subset: gosubset_prok is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015119 name: hexose phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of hexose phosphate from one side of the membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015120 name: phosphoglycerate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphoglycerates from one side of the membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis." [GOC:ai] subset: gosubset_prok is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity [Term] id: GO:0015121 name: phosphoenolpyruvate:phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)." [GOC:bf, GOC:jl] synonym: "phosphoenolpyruvate transmembrane transporter activity" EXACT [] synonym: "phosphoenolpyruvate/phosphate translocator" EXACT [] synonym: "PPT" BROAD [PMID:10488230] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015123 name: acetate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of acetate from one side of the membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity [Term] id: GO:0015124 name: allantoate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of allantoate from one side of the membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [GOC:ai, ISBN:0198547684] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0015125 name: bile acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai] xref: Reactome:20828 "bile acid transmembrane transporter activity" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0015126 name: canalicular bile acid transmembrane transporter activity namespace: molecular_function def: "The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph] is_a: GO:0015125 ! bile acid transmembrane transporter activity [Term] id: GO:0015127 name: bilirubin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of bilirubin from one side of the membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0015128 name: gluconate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of gluconate from one side of the membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042879 ! aldonate transmembrane transporter activity [Term] id: GO:0015129 name: lactate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] xref: Reactome:20840 "lactate transmembrane transporter activity" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0015130 name: mevalonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of mevalonate from one side of the membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0015131 name: oxaloacetate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of the membrane to the other." [GOC:ai] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0015132 name: prostaglandin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [GOC:ai] synonym: "prostaglandin/thromboxane transporter activity" BROAD [] xref: Reactome:20870 "prostaglandin transmembrane transporter activity" is_a: GO:0071714 ! icosanoid transmembrane transporter activity [Term] id: GO:0015133 name: uronic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of uronic acid from one side of the membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [GOC:ai] subset: gosubset_prok is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015145 ! monosaccharide transmembrane transporter activity [Term] id: GO:0015134 name: hexuronate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of hexuronates from one side of the membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015133 ! uronic acid transmembrane transporter activity [Term] id: GO:0015135 name: glucuronate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glucuronate from one side of the membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] is_a: GO:0015134 ! hexuronate transmembrane transporter activity [Term] id: GO:0015136 name: sialic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sialic acid from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015145 ! monosaccharide transmembrane transporter activity [Term] id: GO:0015137 name: citrate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok xref: Reactome:20886 "citrate transmembrane transporter activity" is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity [Term] id: GO:0015138 name: fumarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of fumarate from one side of the membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0015139 name: alpha-ketoglutarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of alpha-ketoglutarate from one side of the membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle." [GOC:ai, ISBN:0198547684] subset: gosubset_prok synonym: "2-oxoglutarate transporter activity" EXACT [] xref: Reactome:20894 "alpha-ketoglutarate transmembrane transporter activity" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0015140 name: malate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of malate from one side of the membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity [Term] id: GO:0015141 name: succinate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity [Term] id: GO:0015142 name: tricarboxylic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [GOC:ai] subset: gosubset_prok synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: Reactome:14023 "tricarboxylic acid transmembrane transporter activity" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0015143 name: urate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of urate from one side of the membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [GOC:ai] synonym: "uric acid transmembrane transporter activity" EXACT [] xref: Reactome:20929 "urate transmembrane transporter activity" is_a: GO:0005342 ! organic acid transmembrane transporter activity [Term] id: GO:0015144 name: carbohydrate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of carbohydrate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sugar transporter" NARROW [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0015145 name: monosaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0051119 ! sugar transmembrane transporter activity [Term] id: GO:0015146 name: pentose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a pentose sugar, a monosaccharide with 5 carbon atoms, from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015145 ! monosaccharide transmembrane transporter activity [Term] id: GO:0015147 name: L-arabinose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-arabinose from one side of the membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] is_a: GO:0042900 ! arabinose transmembrane transporter activity [Term] id: GO:0015148 name: D-xylose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-xylose from one side of the membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok is_a: GO:0015146 ! pentose transmembrane transporter activity [Term] id: GO:0015149 name: hexose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: Reactome:7702 "hexose transmembrane transporter activity" is_a: GO:0015145 ! monosaccharide transmembrane transporter activity [Term] id: GO:0015150 name: fucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of fucose from one side of the membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015151 name: alpha-glucoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of alpha-glucosides from one side of the membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] is_a: GO:0042947 ! glucoside transmembrane transporter activity [Term] id: GO:0015152 name: glucose-6-phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:20967 "glucose-6-phosphate transmembrane transporter activity" is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity [Term] id: GO:0015153 name: rhamnose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of rhamnose from one side of the membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015154 name: disaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of disaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0051119 ! sugar transmembrane transporter activity [Term] id: GO:0015155 name: lactose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019189 def: "Catalysis of the transfer of lactose from one side of the membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "lactose permease activity" EXACT [] synonym: "lactose/glucose efflux transporter activity" NARROW [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0015156 name: melibiose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of melibiose from one side of the membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0015157 name: oligosaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oligosaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "endosomal oligosaccharide transporter" NARROW [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0015158 name: raffinose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of raffinose from one side of the membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "raffinose permease" RELATED [] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity [Term] id: GO:0015159 name: polysaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of polysaccharides from one side of the membrane to the other. A polysaccharide is a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0015160 name: beta-glucan transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of beta-glucans from one side of the membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity [Term] id: GO:0015161 name: capsular polysaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of capsular-polysaccharides from one side of the membrane to the other. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "capsule polysaccharide transporter activity" EXACT [] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity [Term] id: GO:0015162 name: teichoic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of teichoic acid from one side of the membrane to the other. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015159 ! polysaccharide transmembrane transporter activity [Term] id: GO:0015163 name: hexuronide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a hexuronide from one side of the membrane to the other. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0015164 name: glucuronoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a glucuronosides from one side of the membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "glucuronide transporter activity" EXACT [] is_a: GO:0015163 ! hexuronide transmembrane transporter activity [Term] id: GO:0015165 name: pyrimidine nucleotide sugar transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity [Term] id: GO:0015166 name: polyol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sugar/polyol channel activity" NARROW [] xref: Reactome:14150 "polyol transmembrane transporter activity" is_a: GO:0015665 ! alcohol transmembrane transporter activity [Term] id: GO:0015167 name: arabitol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an arabitol from one side of the membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "arabinitol transporter activity" EXACT [] is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015168 name: glycerol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] subset: gosubset_prok is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015169 name: glycerol-3-phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycerol-3-phosphate from one side of the membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] subset: gosubset_prok is_a: GO:0015168 ! glycerol transmembrane transporter activity [Term] id: GO:0015170 name: propanediol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of propanediol from one side of the membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [GOC:ai] is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015171 name: amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0015359 def: "Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "amino acid permease activity" EXACT [] synonym: "amino acid transporter activity" BROAD [] synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "general amino acid permease activity" RELATED [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] xref: Reactome:13305 "amino acid transmembrane transporter activity" is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0015172 name: acidic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "acidic amino acid transporter activity" BROAD [] xref: Reactome:13353 "acidic amino acid transmembrane transporter activity" is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015173 name: aromatic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "aromatic amino acid transporter activity" BROAD [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015174 name: basic amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0005286 def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "basic amino acid permease activity" EXACT [] synonym: "basic amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015175 name: neutral amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "neutral amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015176 name: holin namespace: molecular_function def: "OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some catalyze export of nucleases." [TC:1.A.38.-.-] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0008565 consider: GO:0019835 [Term] id: GO:0015179 name: L-amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-amino acid transporter activity" BROAD [] xref: Reactome:13355 "L-amino acid transmembrane transporter activity" is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015180 name: L-alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "L-alanine transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0022858 ! alanine transmembrane transporter activity [Term] id: GO:0015181 name: arginine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005288 def: "Catalysis of the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "arginine permease activity" EXACT [] synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-arginine transporter activity" NARROW [] is_a: GO:0015174 ! basic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015182 name: L-asparagine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "asparagine/glutamine permease activity" NARROW [] synonym: "L-asparagine transporter activity" BROAD [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015183 name: L-aspartate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-aspartate transporter activity" BROAD [] is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015184 name: L-cystine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-cystine from one side of a membrane to the other." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] synonym: "cystine/diaminopimelate porter activity" NARROW [] synonym: "L-cystine transporter activity" BROAD [] is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015185 name: L-gamma-aminobutyric acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-gamma-aminobutyric acid from one side of a membrane to the other. L-gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "4-aminobutanoate transporter activity" EXACT [] synonym: "4-aminobutyrate transporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "GABA transporter activity" EXACT [] synonym: "L-gamma-aminobutyrate transporter activity" EXACT [] synonym: "L-gamma-aminobutyric acid transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015186 name: L-glutamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "asparagine/glutamine permease activity" NARROW [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015187 name: glycine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai] subset: gosubset_prok synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "glycine transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0015188 name: L-isoleucine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "L-isoleucine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015189 name: L-lysine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005293 def: "Catalysis of the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-lysine permease" RELATED [] synonym: "lysine permease activity" RELATED [] is_a: GO:0015174 ! basic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015190 name: L-leucine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-leucine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015191 name: L-methionine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-methionine transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0043865 ! methionine transmembrane transporter activity [Term] id: GO:0015192 name: L-phenylalanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-phenylalanine permease activity" EXACT [] synonym: "L-phenylalanine transporter activity" BROAD [] is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015193 name: L-proline transmembrane transporter activity namespace: molecular_function alt_id: GO:0005296 def: "Catalysis of the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "L-proline permease activity" RELATED [] synonym: "L-proline transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015194 name: L-serine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015511 def: "Catalysis of the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-serine permease activity" RELATED [] synonym: "L-serine transporter activity" BROAD [] synonym: "serine transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" RELATED [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0022889 ! serine transmembrane transporter activity [Term] id: GO:0015195 name: L-threonine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015512 def: "Catalysis of the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-threonine permease activity" RELATED [] synonym: "L-threonine transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" RELATED [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015196 name: L-tryptophan transmembrane transporter activity namespace: molecular_function alt_id: GO:0005299 def: "Catalysis of the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-tryptophan permease activity" EXACT [] synonym: "L-tryptophan transporter activity" BROAD [] synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015197 name: peptide transporter activity namespace: molecular_function alt_id: GO:0015637 def: "Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells." [GOC:ai] subset: gosubset_prok synonym: "peptide uptake permease activity" RELATED [] is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0015198 name: oligopeptide transporter activity namespace: molecular_function def: "Enables the directed movement of oligopeptides into, out of or within a cell, or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015197 ! peptide transporter activity [Term] id: GO:0015199 name: betaine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of betaine, the N-trimethyl derivative of an amino acid, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity [Term] id: GO:0015200 name: methylammonium transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of methylammonium, CH3NH2, into, out of or within a cell, or between cells." [GOC:ai] is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0015203 name: polyamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of polyamines, organic compounds containing two or more amino groups, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "amine/amide/polyamine channel activity" NARROW [] is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0015204 name: urea transmembrane transporter activity namespace: molecular_function alt_id: GO:0015287 def: "Enables the directed movement of urea cross a membrane into, out of or within a cell, or between cells. Urea is the water soluble compound H2N-CO-NH2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "urea transporter activity" BROAD [] xref: Reactome:21838 "urea transmembrane transporter activity" is_a: GO:0042887 ! amide transmembrane transporter activity [Term] id: GO:0015205 name: nucleobase transmembrane transporter activity namespace: molecular_function alt_id: GO:0015392 def: "Catalysis of the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: GO:0015207 name: adenine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators] xref: Reactome:21842 "adenine transmembrane transporter activity" is_a: GO:0005345 ! purine base transmembrane transporter activity [Term] id: GO:0015208 name: guanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other." [GOC:go_curators] is_a: GO:0005345 ! purine base transmembrane transporter activity [Term] id: GO:0015209 name: cytosine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other." [GOC:go_curators] subset: gosubset_prok is_a: GO:0005350 ! pyrimidine base transmembrane transporter activity [Term] id: GO:0015210 name: uracil transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other." [GOC:go_curators] subset: gosubset_prok synonym: "uracil/uridine permease activity" RELATED [] is_a: GO:0005350 ! pyrimidine base transmembrane transporter activity [Term] id: GO:0015211 name: purine nucleoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0005337 ! nucleoside transmembrane transporter activity [Term] id: GO:0015212 name: cytidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [GOC:go_curators] is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity [Term] id: GO:0015213 name: uridine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of uridine, uracil riboside, from one side of a membrane to the other." [GOC:go_curators] synonym: "uracil/uridine permease activity" NARROW [] is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity [Term] id: GO:0015214 name: pyrimidine nucleoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other." [GOC:ai] is_a: GO:0005337 ! nucleoside transmembrane transporter activity [Term] id: GO:0015215 name: nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: GO:0015216 name: purine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015215 ! nucleotide transmembrane transporter activity [Term] id: GO:0015217 name: ADP transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity [Term] id: GO:0015218 name: pyrimidine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015215 ! nucleotide transmembrane transporter activity [Term] id: GO:0015219 name: protein-DNA complex transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of protein-DNA complexes from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "DNA-protein complex transmembrane transporter activity" EXACT [GOC:mah] is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: GO:0015220 name: choline transmembrane transporter activity namespace: molecular_function alt_id: GO:0005306 def: "Catalysis of the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] subset: gosubset_prok synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "choline permease activity" EXACT [] xref: Reactome:13999 "choline transmembrane transporter activity" is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0015221 name: lipopolysaccharide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lipopolysaccharides from one side of the membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "LPS transmembrane transporter activity" EXACT [] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity [Term] id: GO:0015222 name: serotonin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0008504 ! monoamine transmembrane transporter activity [Term] id: GO:0015223 name: vitamin or cofactor transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "vitamin/cofactor transporter activity" EXACT [] is_obsolete: true consider: GO:0051183 consider: GO:0051184 [Term] id: GO:0015224 name: biopterin transporter activity namespace: molecular_function def: "Enables the directed movement of biopterin into, out of or within a cell, or between cells. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0015225 name: biotin transporter activity namespace: molecular_function def: "Enables the directed movement of biotin into, out of or within a cell, or between cells. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] synonym: "vitamin B7 transporter activity" EXACT [] synonym: "vitamin H transporter activity" EXACT [] is_a: GO:0051183 ! vitamin transporter activity is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0015226 name: carnitine transporter activity namespace: molecular_function def: "Enables the directed movement of carnitine into, out of or within a cell, or between cells. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] subset: gosubset_prok synonym: "vitamin Bt transporter activity" EXACT [] xref: Reactome:21896 "carnitine transporter activity" is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity [Term] id: GO:0015227 name: acyl carnitine transporter activity namespace: molecular_function def: "Enables the directed movement of acyl carnitine into, out of or within a cell, or between cells. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [CHEBI:17387, GOC:ai] synonym: "acylcarnitine transporter activity" EXACT [] xref: Reactome:21898 "acyl carnitine transporter activity" is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0015228 name: coenzyme A transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of coenzyme A across a membrane into, out of or within a cell, or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] synonym: "coenzyme A transporter activity" BROAD [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity is_a: GO:0051185 ! coenzyme transporter activity [Term] id: GO:0015229 name: L-ascorbic acid transporter activity namespace: molecular_function def: "Enables the directed movement of L-ascorbate into, out of or within a cell, or between cells. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "L-ascorbate transporter activity" EXACT [] synonym: "vitamin C transporter activity" EXACT [] xref: Reactome:21900 "L-ascorbic acid transporter activity" is_a: GO:0051183 ! vitamin transporter activity [Term] id: GO:0015230 name: FAD transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of or within a cell, or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "FAD transporter activity" BROAD [] synonym: "flavin adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0015231 name: 5-formyltetrahydrofolate transporter activity namespace: molecular_function def: "Enables the directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells." [GOC:ai] is_a: GO:0008517 ! folic acid transporter activity [Term] id: GO:0015232 name: heme transporter activity namespace: molecular_function def: "Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells." [GOC:ai] subset: gosubset_prok synonym: "haem transporter activity" EXACT [] xref: Reactome:21931 "heme transporter activity" is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0015233 name: pantothenate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pantothenate across a membrane into, out of or within a cell, or between cells. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "pantothenate transporter activity" BROAD [GOC:mah] synonym: "vitamin B5 transmembrane transporter activity" EXACT [] is_a: GO:0051183 ! vitamin transporter activity is_a: GO:0051185 ! coenzyme transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015234 name: thiamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015402 def: "Catalysis of the transfer of thiamine from one side of the membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "thiamin permease activity" EXACT [] synonym: "thiamin transmembrane transporter activity" EXACT [GOC:curators] synonym: "thiamine permease activity" EXACT [] synonym: "vitamin B1 transporter activity" EXACT [] xref: Reactome:21936 "thiamine transmembrane transporter activity" is_a: GO:0022891 ! substrate-specific transmembrane transporter activity is_a: GO:0051183 ! vitamin transporter activity [Term] id: GO:0015235 name: cobalamin transporter activity namespace: molecular_function def: "Enables the directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell." [GOC:ai] subset: gosubset_prok synonym: "vitamin B12 transporter activity" EXACT [] is_a: GO:0051183 ! vitamin transporter activity [Term] id: GO:0015238 name: drug transmembrane transporter activity namespace: molecular_function alt_id: GO:0015239 alt_id: GO:0015559 alt_id: GO:0015564 def: "Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "multidrug efflux pump activity" RELATED [] synonym: "multidrug transporter activity" RELATED [] synonym: "multidrug, alkane resistant pump activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015240 name: amiloride transporter activity namespace: molecular_function def: "Enables the directed movement of amiloride of amiloride into, out of or within a cell, or between cells. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015241 name: aminotriazole transporter activity namespace: molecular_function def: "Enables the directed movement of aminotriazole into, out of or within a cell, or between cells. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [CHEBI:40036, GOC:curators] is_a: GO:0045118 ! azole transporter activity [Term] id: GO:0015242 name: benomyl transporter activity namespace: molecular_function def: "Enables the directed movement of benomyl into, out of or within a cell, or between cells. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [CHEBI:3015, GOC:curators] is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transporter activity [Term] id: GO:0015243 name: cycloheximide transporter activity namespace: molecular_function def: "Enables the directed movement of cycloheximide into, out of or within a cell, or between cells. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042895 ! antibiotic transporter activity [Term] id: GO:0015244 name: fluconazole transporter activity namespace: molecular_function def: "Enables the directed movement of fluconazole into, out of or within a cell, or between cells. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [CHEBI:46081, GOC:curators] is_a: GO:0045118 ! azole transporter activity [Term] id: GO:0015245 name: fatty acid transporter activity namespace: molecular_function def: "Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:14050 "fatty acid transporter activity" is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0015246 name: fatty-acyl group transporter activity namespace: molecular_function def: "Enables the directed movement of a fatty acyl group into, out of or within a cell, or between cells. A fatty acyl group is any acyl group derived from a fatty acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "fatty acyl transporter activity" EXACT [GOC:curators] synonym: "peroxisomal fatty acyl transporter" NARROW [] is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0015247 name: aminophospholipid transporter activity namespace: molecular_function def: "Enables the directed movement of aminophospholipids into, out of or within a cell, or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai] subset: gosubset_prok is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0015248 name: sterol transporter activity namespace: molecular_function def: "Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] xref: Reactome:21984 "sterol transporter activity" is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0015250 name: water channel activity namespace: molecular_function def: "Transport systems of this type catalyze facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "aquaporin" NARROW [] xref: Reactome:22008 "water channel activity" is_a: GO:0005372 ! water transmembrane transporter activity is_a: GO:0022838 ! substrate-specific channel activity [Term] id: GO:0015251 name: ammonium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of ammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005261 ! cation channel activity is_a: GO:0008519 ! ammonium transmembrane transporter activity [Term] id: GO:0015252 name: hydrogen ion channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005261 ! cation channel activity [Term] id: GO:0015253 name: sugar/polyol channel activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two molecular functions. is_obsolete: true consider: GO:0015166 consider: GO:0051119 [Term] id: GO:0015254 name: glycerol channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: Reactome:22018 "glycerol channel activity" is_a: GO:0015168 ! glycerol transmembrane transporter activity [Term] id: GO:0015255 name: propanediol channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] is_a: GO:0015170 ! propanediol transmembrane transporter activity [Term] id: GO:0015256 name: monocarboxylate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. is_obsolete: true [Term] id: GO:0015257 name: organic anion channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. is_obsolete: true [Term] id: GO:0015258 name: gluconate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. is_obsolete: true [Term] id: GO:0015259 name: glutamate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. is_obsolete: true [Term] id: GO:0015260 name: isethionate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. is_obsolete: true [Term] id: GO:0015261 name: lactate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. is_obsolete: true [Term] id: GO:0015262 name: taurine channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. is_obsolete: true [Term] id: GO:0015263 name: amine/amide/polyamine channel activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents three molecular functions. is_obsolete: true consider: GO:0005275 consider: GO:0015203 consider: GO:0042887 [Term] id: GO:0015264 name: methylammonium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2." [GOC:mtg_transport] is_a: GO:0015200 ! methylammonium transmembrane transporter activity [Term] id: GO:0015265 name: urea channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] xref: Reactome:22068 "urea channel activity" is_a: GO:0015204 ! urea transmembrane transporter activity is_a: GO:0022838 ! substrate-specific channel activity [Term] id: GO:0015266 name: protein channel activity namespace: molecular_function def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel." [GOC:rb] is_a: GO:0008320 ! protein transmembrane transporter activity is_a: GO:0015267 ! channel activity [Term] id: GO:0015267 name: channel activity namespace: molecular_function alt_id: GO:0015249 alt_id: GO:0015268 def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-] subset: gosubset_prok synonym: "alpha-type channel activity" RELATED [] synonym: "channel-forming toxin activity" RELATED [] synonym: "channel/pore class transporter activity" EXACT [] synonym: "nonselective channel activity" EXACT [] synonym: "pore activity" BROAD [] synonym: "pore class transporter activity" RELATED [] xref: TC:1 is_a: GO:0022803 ! passive transmembrane transporter activity [Term] id: GO:0015269 name: calcium-activated potassium channel activity namespace: molecular_function def: "Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] subset: gosubset_prok is_a: GO:0005227 ! calcium activated cation channel activity is_a: GO:0005267 ! potassium channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0015271 name: outward rectifier potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah] is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0015272 name: ATP-activated inward rectifier potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah] is_a: GO:0005242 ! inward rectifier potassium channel activity [Term] id: GO:0015274 name: organellar voltage-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "organellar voltage gated chloride channel activity" EXACT [] synonym: "organellar voltage-dependent chloride channel activity" EXACT [] is_a: GO:0005247 ! voltage-gated chloride channel activity [Term] id: GO:0015275 name: stretch-activated, cation-selective, calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [GOC:mtg_transport] is_a: GO:0005262 ! calcium channel activity is_a: GO:0008381 ! mechanically-gated ion channel activity [Term] id: GO:0015276 name: ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "ionotropic neurotransmitter receptor" NARROW [] xref: Reactome:4234 "ligand-gated ion channel activity" is_a: GO:0005216 ! ion channel activity is_a: GO:0022834 ! ligand-gated channel activity [Term] id: GO:0015277 name: kainate selective glutamate receptor activity namespace: molecular_function def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. is_a: GO:0004970 ! ionotropic glutamate receptor activity [Term] id: GO:0015278 name: calcium-release channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0005262 ! calcium channel activity is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0015279 name: store-operated calcium channel activity namespace: molecular_function def: "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710] xref: Reactome:22120 "store-operated calcium channel activity" is_a: GO:0005262 ! calcium channel activity is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0015280 name: ligand-gated sodium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] synonym: "amiloride-sensitive sodium channel activity" EXACT [] synonym: "epithelial sodium channel" EXACT [] is_a: GO:0005272 ! sodium channel activity is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0015282 name: NADPH oxidase-associated cytochrome b558 hydrogen channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it describes a gene product rather than a function. synonym: "NADPH oxidase-associated cytochrome b558 proton channel" EXACT [] is_obsolete: true [Term] id: GO:0015283 name: apoptogenic cytochrome c release channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it represents a gene product. synonym: "Bcl-2" NARROW [] is_obsolete: true [Term] id: GO:0015284 name: fructose uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13] is_a: GO:0005353 ! fructose transmembrane transporter activity is_a: GO:0008516 ! hexose uniporter activity [Term] id: GO:0015288 name: porin activity namespace: molecular_function def: "Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] subset: gosubset_prok synonym: "outer membrane exporter porin" NARROW [] synonym: "porin" EXACT [] xref: Wikipedia:Porin_(protein) is_a: GO:0022829 ! wide pore channel activity [Term] id: GO:0015289 name: pore-forming toxin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell." [PMID:10839820] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0005198 consider: GO:0009405 consider: GO:0046930 consider: GO:0046931 consider: GO:0050827 [Term] id: GO:0015291 name: secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0015290 alt_id: GO:0015353 alt_id: GO:0015404 alt_id: GO:0015570 def: "Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "active transporter" BROAD [] synonym: "coupled carrier" EXACT [] synonym: "electrochemical potential-driven transporter activity" EXACT [] synonym: "energizer of outer membrane receptor-mediated transport activity" NARROW [] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] synonym: "heavy metal ion porter activity" NARROW [] synonym: "ion-gradient-driven energizer activity" NARROW [] synonym: "multidrug endosomal transmembrane transporter activity" NARROW [] synonym: "nitrite/nitrate porter activity" NARROW [] synonym: "porter activity" EXACT [] synonym: "porters" EXACT [] synonym: "secondary carrier-type facilitators" EXACT [] xref: Reactome:3124 "secondary active transmembrane transporter activity" xref: TC:2.A is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0015292 name: uniporter activity namespace: molecular_function def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "facilitated diffusion carrier" EXACT [] synonym: "single-species transporter activity" EXACT [] synonym: "uniport" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015293 name: symporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "cotransporter activity" BROAD [] synonym: "porter activity" BROAD [] synonym: "symport" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015294 name: solute:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai] subset: gosubset_prok is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015293 ! symporter activity [Term] id: GO:0015295 name: solute:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [GOC:ai] subset: gosubset_prok synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] synonym: "solute:proton symporter activity" EXACT [] is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015296 name: anion:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-] subset: gosubset_prok is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015297 name: antiporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "antiport" RELATED [] synonym: "countertransporter activity" EXACT [] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] synonym: "exchange transporter activity" EXACT [] synonym: "exchanger" BROAD [] synonym: "porter" BROAD [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015298 name: solute:cation antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai] subset: gosubset_prok is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0015299 name: solute:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] subset: gosubset_prok synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] synonym: "solute:proton antiporter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015298 ! solute:cation antiporter activity [Term] id: GO:0015300 name: solute:solute antiporter activity namespace: molecular_function def: "Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:ai] subset: gosubset_prok synonym: "solute:solute exchange" RELATED [] is_a: GO:0015297 ! antiporter activity [Term] id: GO:0015301 name: anion:anion antiporter activity namespace: molecular_function alt_id: GO:0015380 alt_id: GO:0015384 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out)." [GOC:ai, GOC:mtg_transport] subset: gosubset_prok synonym: "anion exchanger activity" EXACT [] synonym: "bicarbonate:chloride antiporter" NARROW [] xref: Reactome:15032 "anion:anion antiporter activity" is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0015303 name: galactose, glucose uniporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in)." [TC:2.A.1.1.6] comment: This term was made obsolete because it represents two molecular functions. is_obsolete: true consider: GO:0015304 consider: GO:0050782 [Term] id: GO:0015304 name: glucose uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)." [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6] synonym: "galactose, glucose uniporter activity" NARROW [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008516 ! hexose uniporter activity [Term] id: GO:0015305 name: lactose, galactose:hydrogen symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in)." [TC:2.A.1.1.9] comment: This term was made obsolete because it represents two molecular functions. synonym: "lactose,galactose:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015517 consider: GO:0015528 [Term] id: GO:0015306 name: sialate:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)." [TC:2.A.1.14.10] synonym: "cation/sialate symporter activity" EXACT [] synonym: "cation:sialate symporter activity" EXACT [] synonym: "sialate transporter activity" BROAD [] synonym: "sialate/cation symporter activity" EXACT [] is_a: GO:0005402 ! cation:sugar symporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015307 name: drug:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out)." [TC:2.A.1.2.-, TC:2.A.1.3.-] subset: gosubset_prok synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] synonym: "drug:proton antiporter activity" EXACT [] xref: Reactome:13295 "drug:hydrogen antiporter activity" is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0015299 ! solute:hydrogen antiporter activity [Term] id: GO:0015308 name: amiloride:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out)." [TC:2.A.1.2.1] synonym: "amiloride:proton antiporter activity" EXACT [] is_a: GO:0015240 ! amiloride transporter activity is_a: GO:0015307 ! drug:hydrogen antiporter activity [Term] id: GO:0015309 name: cycloheximide:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2] synonym: "cycloheximide:proton antiporter activity" EXACT [] is_a: GO:0015307 ! drug:hydrogen antiporter activity [Term] id: GO:0015310 name: benomyl:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6] synonym: "benomyl:proton antiporter activity" EXACT [] is_a: GO:0015307 ! drug:hydrogen antiporter activity [Term] id: GO:0015311 name: monoamine:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12] synonym: "monoamine:proton antiporter activity" EXACT [] is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0015299 ! solute:hydrogen antiporter activity [Term] id: GO:0015312 name: polyamine:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16] synonym: "polyamine:proton antiporter activity" EXACT [] is_a: GO:0015203 ! polyamine transmembrane transporter activity is_a: GO:0015299 ! solute:hydrogen antiporter activity [Term] id: GO:0015313 name: fluconazole:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17] synonym: "fluconazole:proton antiporter activity" EXACT [] is_a: GO:0015244 ! fluconazole transporter activity is_a: GO:0045119 ! azole:hydrogen antiporter activity [Term] id: GO:0015314 name: aminotriazole:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1] synonym: "aminotriazole:proton antiporter activity" EXACT [] is_a: GO:0015241 ! aminotriazole transporter activity is_a: GO:0045119 ! azole:hydrogen antiporter activity [Term] id: GO:0015315 name: organophosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.-] is_a: GO:0015114 ! phosphate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015316 name: nitrite/nitrate porter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0015112 consider: GO:0015113 consider: GO:0015291 [Term] id: GO:0015317 name: phosphate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] synonym: "phosphate:proton symporter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015114 ! phosphate transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015318 name: inorganic solute uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an inorganic solute from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "inorganic uptake permease activity" EXACT [] is_a: GO:0015114 ! phosphate transmembrane transporter activity is_a: GO:0015563 ! uptake transmembrane transporter activity [Term] id: GO:0015319 name: sodium:inorganic phosphate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)." [TC:2.A.1.14.6] is_a: GO:0005436 ! sodium:phosphate symporter activity [Term] id: GO:0015320 name: phosphate carrier activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate (cyt) + H+ (cyt) = phosphate (mitochondrion) + H+ (mitochondrion)." [GOC:curators, TC:2.A.29.4.1] is_a: GO:0015114 ! phosphate transmembrane transporter activity [Term] id: GO:0015321 name: sodium-dependent phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl] subset: gosubset_prok xref: Reactome:22863 "sodium-dependent phosphate transmembrane transporter activity" is_a: GO:0015114 ! phosphate transmembrane transporter activity [Term] id: GO:0015322 name: secondary active oligopeptide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an oligopeptide or oligopeptides from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] subset: gosubset_prok synonym: "oligopeptide porter activity" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0035673 ! oligopeptide transmembrane transporter activity [Term] id: GO:0015323 name: type V protein secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. is_obsolete: true [Term] id: GO:0015324 name: peptide-acetyl-CoA secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "peptide-acetyl-CoA transporter activity" RELATED [] is_a: GO:0015197 ! peptide transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015325 name: acetyl-CoA:CoA antiporter activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1] is_a: GO:0008521 ! acetyl-CoA transporter activity is_a: GO:0015300 ! solute:solute antiporter activity is_a: GO:0015324 ! peptide-acetyl-CoA secondary active transmembrane transporter activity [Term] id: GO:0015326 name: cationic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a positively charged amino acid from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015327 name: cystine:glutamate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5] is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0005313 ! L-glutamate transmembrane transporter activity is_a: GO:0015184 ! L-cystine transmembrane transporter activity is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0015328 name: cystine secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "cystine porter activity" RELATED [] synonym: "cystinosin" NARROW [] synonym: "lysosomal cystine transporter" NARROW [] is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0015184 ! L-cystine transmembrane transporter activity [Term] id: GO:0015330 name: high affinity glutamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the high affinity transfer of glutamine from one side of the membrane to the other." [GOC:mtg_transport] synonym: "high affinity glutamine permease activity" RELATED [] is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity is_a: GO:0015186 ! L-glutamine transmembrane transporter activity [Term] id: GO:0015331 name: asparagine/glutamine permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0015182 consider: GO:0015186 consider: GO:0022857 [Term] id: GO:0015332 name: leucine/valine/isoleucine permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005304 consider: GO:0015188 consider: GO:0015190 consider: GO:0022857 [Term] id: GO:0015333 name: peptide:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement." [GOC:mtg_transport, TC:2.A.17.-.-] subset: gosubset_prok synonym: "peptide:proton symporter activity" EXACT [] xref: Reactome:22899 "peptide:hydrogen symporter activity" is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0022897 ! proton-dependent peptide secondary active transmembrane transporter activity [Term] id: GO:0015334 name: high affinity oligopeptide transporter activity namespace: molecular_function def: "Catalysis of the transfer of oligopeptide from one side of the membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:mtg_transport] is_a: GO:0015198 ! oligopeptide transporter activity [Term] id: GO:0015335 name: heavy metal ion:hydrogen symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:2.A.55.2.1, TC:2.A.55.2.2] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "heavy metal ion:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015295 consider: GO:0046873 [Term] id: GO:0015336 name: high affinity metal ion uptake transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+." [TC:2.A.55.1.1] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0015295 consider: GO:0046873 [Term] id: GO:0015337 name: low affinity metal ion uptake transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+." [TC:2.A.55.1.2] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0015295 consider: GO:0046873 [Term] id: GO:0015339 name: cobalt, zinc uptake permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.1] comment: This term was made obsolete because it represents more than one molecular function. is_obsolete: true consider: GO:0005385 consider: GO:0015087 consider: GO:0015563 [Term] id: GO:0015340 name: zinc, cadmium uptake permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.2] comment: This term was made obsolete because it represents more than one molecular function. is_obsolete: true consider: GO:0005385 consider: GO:0015086 consider: GO:0015563 [Term] id: GO:0015341 name: zinc efflux active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3] synonym: "zinc efflux permease activity" BROAD [] is_a: GO:0005261 ! cation channel activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022883 ! zinc efflux transmembrane transporter activity [Term] id: GO:0015342 name: zinc, iron permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force." [TC:2.A.5.-.-] comment: This term was made obsolete because it represents more than one molecular function. is_obsolete: true consider: GO:0005381 consider: GO:0005385 consider: GO:0015563 [Term] id: GO:0015343 name: siderophore transmembrane transporter activity namespace: molecular_function alt_id: GO:0015236 alt_id: GO:0015237 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [TC:2.A.1.16.-] subset: gosubset_prok synonym: "iron-siderophore transporter activity" EXACT [] synonym: "siderochrome-iron transporter activity" NARROW [] synonym: "siderophore-iron transmembrane transporter activity" RELATED [] is_a: GO:0005381 ! iron ion transmembrane transporter activity is_a: GO:0042927 ! siderophore transporter activity [Term] id: GO:0015344 name: siderophore uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [TC:2.A.1.16.1] synonym: "ferrioxamine uptake transmembrane transporter activity" RELATED [] synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW [] synonym: "siderophore-iron uptake transmembrane transporter activity" RELATED [] is_a: GO:0015343 ! siderophore transmembrane transporter activity [Term] id: GO:0015345 name: ferric enterobactin:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2] synonym: "ferric-enterobactin:proton symporter activity" EXACT [] is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015620 ! ferric-enterobactin transmembrane transporter activity [Term] id: GO:0015346 name: ferric triacetylfusarinine C:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3] synonym: "ferric triacetylfusarinine C:proton symporter activity" EXACT [] is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0015621 ! ferric triacetylfusarinine C transmembrane transporter activity [Term] id: GO:0015347 name: sodium-independent organic anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner." [GOC:go_curators] xref: Reactome:22945 "sodium-independent organic anion transmembrane transporter activity" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015348 name: prostaglandin/thromboxane transporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0008028 consider: GO:0015132 [Term] id: GO:0015349 name: thyroid hormone transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of thyroid hormones from one side of the membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai] xref: Reactome:22947 "thyroid hormone transmembrane transporter activity" is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015350 name: methotrexate transporter activity namespace: molecular_function def: "Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015351 name: bilirubin secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "bilirubin porter activity" RELATED [] synonym: "bilitranslocase" NARROW [] is_a: GO:0015127 ! bilirubin transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015352 name: secondary active sterol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sterol from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] synonym: "sterol porter activity" RELATED [] is_a: GO:0015248 ! sterol transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015355 name: secondary active monocarboxylate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl] synonym: "monocarboxylate porter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015356 name: monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0015129 consider: GO:0015130 consider: GO:0015562 consider: GO:0015563 consider: GO:0050833 [Term] id: GO:0015358 name: amino acid/choline transmembrane transporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0015171 consider: GO:0015220 [Term] id: GO:0015360 name: acetate:hydrogen symporter activity namespace: molecular_function alt_id: GO:0015357 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1] synonym: "acetate:proton symporter activity" EXACT [] synonym: "hydrogen:acetate symporter activity" EXACT [] is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0043893 ! acetate:cation symporter activity [Term] id: GO:0015361 name: low affinity sodium:dicarboxylate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1] synonym: "low affinity sodium:dicarboxylate cotransporter activity" BROAD [] xref: Reactome:22991 "low affinity sodium:dicarboxylate symporter activity" is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] id: GO:0015362 name: high affinity sodium:dicarboxylate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4] synonym: "high affinity sodium:dicarboxylate cotransporter activity" BROAD [] xref: Reactome:22994 "high affinity sodium:dicarboxylate symporter activity" is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] id: GO:0015363 name: dicarboxylate (succinate/fumarate/malate) antiporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005310 consider: GO:0015138 consider: GO:0015140 consider: GO:0015141 consider: GO:0015297 [Term] id: GO:0015364 name: dicarboxylate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)." [TC:2.A.29.2.3] is_a: GO:0015114 ! phosphate transmembrane transporter activity is_a: GO:0015297 ! antiporter activity [Term] id: GO:0015366 name: malate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)." [TC:2.A.16.2.1] synonym: "malate:proton symporter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015140 ! malate transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015367 name: oxoglutarate:malate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1] xref: Reactome:23001 "oxoglutarate:malate antiporter activity" is_a: GO:0015140 ! malate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015368 name: calcium:cation antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-] subset: gosubset_prok xref: Reactome:14992 "calcium:cation antiporter activity" is_a: GO:0015085 ! calcium ion transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0015369 name: calcium:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [TC:2.A.19.2.-] subset: gosubset_prok synonym: "calcium:proton antiporter activity" EXACT [] is_a: GO:0015368 ! calcium:cation antiporter activity is_a: GO:0051139 ! metal ion:hydrogen antiporter activity [Term] id: GO:0015370 name: solute:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015371 name: galactose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] is_a: GO:0005354 ! galactose transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015372 name: glutamate/aspartate:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in)." [TC:2.A.23.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005283 consider: GO:0005313 consider: GO:0015183 [Term] id: GO:0015373 name: monovalent anion:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in)." [TC:2.A.21.5.-] is_a: GO:0015296 ! anion:cation symporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015374 name: neutral, cationic amino acid:sodium:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/cationic amino acid(out) + Na+(out) + Cl-(out) = neutral/cationic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3] is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0015375 name: glycine:sodium symporter activity namespace: molecular_function alt_id: GO:0015656 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)." [GOC:ai] xref: Reactome:23016 "glycine:sodium symporter activity" is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0015187 ! glycine transmembrane transporter activity [Term] id: GO:0015376 name: betaine/GABA:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (betaine or gamma-aminobutyric acid)(out) + Na+(out) = (betaine or gamma-aminobutyric acid)(in) + Na+(in)." [TC:2.A.22.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005332 consider: GO:0015185 consider: GO:0015199 consider: GO:0015370 [Term] id: GO:0015377 name: cation:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-] synonym: "cation:chloride cotransporter activity" BROAD [] is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015378 name: sodium:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-] xref: Reactome:23020 "sodium:chloride symporter activity" is_a: GO:0015377 ! cation:chloride symporter activity [Term] id: GO:0015379 name: potassium:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.5.-] xref: Reactome:23021 "potassium:chloride symporter activity" is_a: GO:0015377 ! cation:chloride symporter activity [Term] id: GO:0015381 name: high affinity sulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the secondary active high affinity transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity sulfate permease activity" RELATED [] synonym: "high affinity sulphate permease activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity [Term] id: GO:0015382 name: sodium:sulfate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2] synonym: "sodium:sulfate cotransporter activity" BROAD [] synonym: "sodium:sulphate symporter activity" EXACT [] xref: Reactome:23041 "sodium:sulfate symporter activity" is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015383 name: sulfate:bicarbonate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2] synonym: "sulphate:bicarbonate antiporter activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015106 ! bicarbonate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015385 name: sodium:hydrogen antiporter activity namespace: molecular_function alt_id: GO:0015502 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] subset: gosubset_prok synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW [] synonym: "pH-dependent sodium:proton antiporter activity" NARROW [] synonym: "sodium/hydrogen antiporter activity" EXACT [] synonym: "sodium:hydrogen exchange activity" EXACT [] synonym: "sodium:hydrogen exchanger" EXACT [] synonym: "sodium:proton antiporter activity" EXACT [] xref: Reactome:23043 "sodium:hydrogen antiporter activity" is_a: GO:0005451 ! monovalent cation:hydrogen antiporter activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity [Term] id: GO:0015386 name: potassium:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-] subset: gosubset_prok synonym: "potassium:proton antiporter activity" EXACT [] is_a: GO:0005451 ! monovalent cation:hydrogen antiporter activity is_a: GO:0022821 ! potassium ion antiporter activity [Term] id: GO:0015387 name: potassium:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)." [TC:2.A.38.-.-] synonym: "potassium:proton symporter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0022820 ! potassium ion symporter activity [Term] id: GO:0015388 name: potassium uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of potassium from the outside of a cell to the inside of the cell across a membrane: K+(out) + energy = K+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.72.2.-] synonym: "potassium uptake permease activity" EXACT [] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015563 ! uptake transmembrane transporter activity [Term] id: GO:0015389 name: pyrimidine- and adenine-specific:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in)." [TC:2.A.41.2.3] is_a: GO:0005345 ! purine base transmembrane transporter activity is_a: GO:0005350 ! pyrimidine base transmembrane transporter activity is_a: GO:0005415 ! nucleoside:sodium symporter activity [Term] id: GO:0015390 name: purine-specific nucleoside:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1] is_a: GO:0005415 ! nucleoside:sodium symporter activity is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity [Term] id: GO:0015391 name: nucleobase:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [GOC:ai] subset: gosubset_prok is_a: GO:0015205 ! nucleobase transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015393 name: uracil/uridine permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0015210 consider: GO:0015213 consider: GO:0022857 [Term] id: GO:0015394 name: uridine:hydrogen ion symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)." [GOC:mtg_transport] synonym: "nucleoside (uridine) permease activity" RELATED [] is_a: GO:0015213 ! uridine transmembrane transporter activity is_a: GO:0015391 ! nucleobase:cation symporter activity is_a: GO:0015506 ! nucleoside:hydrogen symporter activity [Term] id: GO:0015395 name: nucleoside transmembrane transporter activity, down a concentration gradient namespace: molecular_function alt_id: GO:0015396 alt_id: GO:0015397 def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." [PMID:10353709, PMID:11749958, PMID:12446811] synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity" NARROW [] synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity" NARROW [] synonym: "equilibrative nucleoside transporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015398 name: high affinity secondary active ammonium transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015399 name: primary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources." [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-] subset: gosubset_prok synonym: "primary active transporter" RELATED [] xref: TC:3 is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0015400 name: low affinity secondary active ammonium transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "low affinity ammonium transmembrane transporter activity" RELATED [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015401 name: urea:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1] synonym: "urea active transmembrane transporter activity" EXACT [] is_a: GO:0015204 ! urea transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015403 name: thiamine uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of thiamine from the outside of a cell to the inside across a membrane." [GOC:mtg_transport] synonym: "thiamin uptake transporter activity" EXACT [GOC:curators] is_a: GO:0015234 ! thiamine transmembrane transporter activity is_a: GO:0015563 ! uptake transmembrane transporter activity [Term] id: GO:0015405 name: P-P-bond-hydrolysis-driven transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.-.-.-] subset: gosubset_prok synonym: "P-P-bond-hydrolysis-driven transporters" EXACT [] xref: TC:3.A is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015406 name: ABC-type uptake permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0015407 name: monosaccharide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported." [EC:3.6.3.17] subset: gosubset_prok synonym: "ATP phosphohydrolase (monosaccharide-importing)" EXACT [EC:3.6.3.17] synonym: "monosaccharide ABC transporter" NARROW [] synonym: "monosaccharide-importing ATPase activity" NARROW [] xref: EC:3.6.3.17 xref: MetaCyc:3.6.3.17-RXN is_a: GO:0015145 ! monosaccharide transmembrane transporter activity is_a: GO:0043211 ! carbohydrate-transporting ATPase activity [Term] id: GO:0015408 name: ferric-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30] subset: gosubset_prok synonym: "ATP phosphohydrolase (ferric-ion-transporting)" EXACT [EC:3.6.3.30] synonym: "Fe3+-transporting ATPase activity" EXACT [EC:3.6.3.30] synonym: "ferric ABC transporter" NARROW [] synonym: "ferric transporting ATPase activity" EXACT [] xref: EC:3.6.3.30 xref: MetaCyc:3.6.3.30-RXN is_a: GO:0015091 ! ferric iron transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0015410 name: manganese-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [EC:3.6.3.35] subset: gosubset_prok synonym: "ABC-type manganese permease complex" RELATED [EC:3.6.3.35] synonym: "ATP phosphohydrolase (manganese-importing)" EXACT [EC:3.6.3.35] synonym: "manganese ABC transporter" NARROW [] synonym: "manganese transporting ATPase activity" EXACT [] xref: EC:3.6.3.35 xref: MetaCyc:3.6.3.35-RXN is_a: GO:0005384 ! manganese ion transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0015411 name: taurine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [EC:3.6.3.36] synonym: "ATP phosphohydrolase (taurine-importing)" EXACT [EC:3.6.3.36] synonym: "taurine (2-aminoethane sulfonate) porter activity" EXACT [] synonym: "taurine ABC transporter" NARROW [] xref: EC:3.6.3.36 xref: MetaCyc:3.6.3.36-RXN is_a: GO:0005368 ! taurine transmembrane transporter activity is_a: GO:0031263 ! amine-transporting ATPase activity [Term] id: GO:0015412 name: molybdate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [EC:3.6.3.29] subset: gosubset_prok synonym: "ATP phosphohydrolase (molybdate-importing)" EXACT [EC:3.6.3.29] synonym: "molybdate ABC transporter" NARROW [] synonym: "molybdate porter activity" EXACT [] synonym: "molybdate transporting ATPase activity" EXACT [] synonym: "molybdate-transporting ATPase activity" EXACT [EC:3.6.3.29] xref: EC:3.6.3.29 xref: MetaCyc:3.6.3.29-RXN is_a: GO:0015098 ! molybdate ion transmembrane transporter activity is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity [Term] id: GO:0015413 name: nickel-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)." [EC:3.6.3.24] synonym: "ATP phosphohydrolase (nickel-importing)" EXACT [EC:3.6.3.24] synonym: "nickel ABC transporter" NARROW [] synonym: "nickel porter activity" EXACT [] synonym: "nickel transporting ATPase activity" EXACT [] xref: EC:3.6.3.24 xref: MetaCyc:3.6.3.24-RXN is_a: GO:0015099 ! nickel ion transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0015414 name: nitrate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)." [EC:3.6.3.26] synonym: "ATP phosphohydrolase (nitrate-importing)" EXACT [EC:3.6.3.26] synonym: "nitrate ABC transporter" NARROW [] synonym: "nitrate transporting ATPase activity" EXACT [] synonym: "nitrate-transporting ATPase activity" EXACT [EC:3.6.3.26] xref: EC:3.6.3.26 xref: MetaCyc:3.6.3.26-RXN is_a: GO:0015112 ! nitrate transmembrane transporter activity is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity [Term] id: GO:0015415 name: phosphate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)." [EC:3.6.3.27] subset: gosubset_prok synonym: "ABC phosphate transporter activity" NARROW [EC:3.6.3.27] synonym: "ATP phosphohydrolase (phosphate-importing)" EXACT [EC:3.6.3.27] synonym: "phosphate ABC transporter" NARROW [] synonym: "phosphate porter activity" EXACT [] synonym: "phosphate transporting ATPase activity" EXACT [] synonym: "phosphate-transporting ATPase activity" EXACT [EC:3.6.3.27] xref: EC:3.6.3.27 xref: MetaCyc:3.6.3.27-RXN is_a: GO:0015114 ! phosphate transmembrane transporter activity is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity [Term] id: GO:0015416 name: phosphonate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28] synonym: "ATP phosphohydrolase (phosphonate-transporting)" EXACT [EC:3.6.3.28] synonym: "phosphonate ABC transporter" NARROW [] synonym: "phosphonate transporting ATPase activity" EXACT [] synonym: "phosphonate-transporting ATPase activity" EXACT [EC:3.6.3.28] xref: EC:3.6.3.28 xref: MetaCyc:3.6.3.28-RXN is_a: GO:0015604 ! phosphonate transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity [Term] id: GO:0015417 name: polyamine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31] subset: gosubset_prok synonym: "ATP phosphohydrolase (polyamine-importing) activity" EXACT [EC:3.6.3.31] synonym: "polyamine ABC transporter" NARROW [] synonym: "polyamine porter activity" EXACT [] synonym: "polyamine-importing ATPase activity" NARROW [] xref: EC:3.6.3.31 xref: MetaCyc:3.6.3.31-RXN is_a: GO:0015203 ! polyamine transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015418 name: quaternary-ammonium-compound-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32] subset: gosubset_prok synonym: "ATP phosphohydrolase (quaternary-amine-importing) activity" EXACT [EC:3.6.3.32] synonym: "glycine betaine/proline porter activity" RELATED [] synonym: "quaternary amine uptake transporter activity" EXACT [] synonym: "quaternary-amine-transporting ATPase activity" EXACT [] synonym: "quaternary-ammonium-compound ABC transporter" NARROW [] xref: EC:3.6.3.32 xref: MetaCyc:3.6.3.32-RXN is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015419 name: sulfate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)." [EC:3.6.3.25] subset: gosubset_prok synonym: "ATP phosphohydrolase (sulfate-importing) activity" EXACT [EC:3.6.3.25] synonym: "sulfate ABC transporter" NARROW [] synonym: "sulfate transporting ATPase activity" EXACT [] synonym: "sulfate-transporting ATPase activity" EXACT [EC:3.6.3.25] synonym: "sulfate/thiosulfate porter activity" EXACT [] synonym: "sulphate transporting ATPase activity" EXACT [] synonym: "sulphate-transporting ATPase activity" EXACT [] xref: EC:3.6.3.25 xref: MetaCyc:3.6.3.25-RXN xref: Reactome:23447 "sulfate transmembrane-transporting ATPase activity" is_a: GO:0015116 ! sulfate transmembrane transporter activity is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity [Term] id: GO:0015420 name: cobalamin-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + cob(III)alamin(out) = ADP + phosphate + cob(III)alamin(in). Cobalamin is also known as vitamin B12." [EC:3.6.3.33] subset: gosubset_prok synonym: "ATP phosphohydrolase (vitamin B12-importing)" EXACT [EC:3.6.3.33] synonym: "cobalamin ABC transporter" NARROW [] synonym: "cobalamin porter activity" EXACT [] synonym: "vitamin B12 porter activity" EXACT [] synonym: "vitamin B12-transporting ATPase activity" EXACT [] xref: EC:3.6.3.33 xref: MetaCyc:3.6.3.33-RXN xref: RHEA:17876 is_a: GO:0015235 ! cobalamin transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015421 name: oligopeptide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [EC:3.6.3.23] subset: gosubset_prok synonym: "ATP phosphohydrolase (oligopeptide-importing)" EXACT [EC:3.6.3.23] synonym: "oligopeptide ABC transporter" NARROW [] synonym: "oligopeptide permease activity" RELATED [EC:3.6.3.23] xref: EC:3.6.3.23 xref: MetaCyc:3.6.3.23-RXN is_a: GO:0015440 ! peptide-transporting ATPase activity is_a: GO:0035673 ! oligopeptide transmembrane transporter activity [Term] id: GO:0015422 name: oligosaccharide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)." [EC:3.6.3.18] subset: gosubset_prok synonym: "ATP phosphohydrolase (disaccharide-importing)" EXACT [EC:3.6.3.18] synonym: "oligosaccharide ABC transporter" NARROW [] xref: EC:3.6.3.18 xref: MetaCyc:3.6.3.18-RXN is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015423 name: maltose-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)." [EC:3.6.3.19] subset: gosubset_prok synonym: "ATP phosphohydrolase (maltose-importing)" EXACT [EC:3.6.3.19] synonym: "maltose ABC transporter" NARROW [] xref: EC:3.6.3.19 xref: MetaCyc:3.6.3.19-RXN is_a: GO:0005363 ! maltose transmembrane transporter activity is_a: GO:0015422 ! oligosaccharide-transporting ATPase activity [Term] id: GO:0015424 name: amino acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)." [GOC:ai, GOC:mah] subset: gosubset_prok synonym: "amino acid ABC transporter" NARROW [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0031263 ! amine-transporting ATPase activity [Term] id: GO:0015425 name: nonpolar-amino acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22] synonym: "ATP phosphohydrolase (nonpolar-amino-acid-transporting) activity" EXACT [EC:3.6.3.22] synonym: "leucine/isoleucine/valine porter activity" RELATED [] synonym: "nonpolar amino acid-transporting ATPase activity" EXACT [] synonym: "nonpolar-amino acid ABC transporter" NARROW [] synonym: "nonpolar-amino-acid-transporting ATPase activity" EXACT [] xref: EC:3.6.3.22 xref: MetaCyc:3.6.3.22-RXN is_a: GO:0015424 ! amino acid-transporting ATPase activity [Term] id: GO:0015426 name: polar-amino acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21] subset: gosubset_prok synonym: "ATP phosphohydrolase (polar-amino-acid-importing) activity" EXACT [EC:3.6.3.21] synonym: "cystine/diaminopimelate porter activity" RELATED [] synonym: "glutamate/aspartate porter activity" RELATED [] synonym: "histidine permease activity" NARROW [EC:3.6.3.21] synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "polar amino acid uptake transporter activity" EXACT [] synonym: "polar amino acid-importing ATPase activity" EXACT [] synonym: "polar-amino acid ABC transporter" NARROW [] synonym: "polar-amino acid-importing ATPase activity" EXACT [] synonym: "polar-amino-acid-transporting ATPase activity" EXACT [EC:3.6.3.21] xref: EC:3.6.3.21 xref: MetaCyc:3.6.3.21-RXN is_a: GO:0015424 ! amino acid-transporting ATPase activity [Term] id: GO:0015427 name: ABC-type efflux porter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0015428 name: type I protein secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. is_obsolete: true [Term] id: GO:0015429 name: peroxisomal fatty acyl transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and it contains both component and function information. is_obsolete: true consider: GO:0005777 consider: GO:0015246 [Term] id: GO:0015430 name: glycerol-3-phosphate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)." [EC:3.6.3.20] subset: gosubset_prok synonym: "ATP phosphohydrolase (glycerol-3-phosphate-importing)" EXACT [EC:3.6.3.20] synonym: "glycerol-3-phosphate ABC transporter" NARROW [] xref: EC:3.6.3.20 xref: MetaCyc:3.6.3.20-RXN is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015431 name: glutathione S-conjugate-exporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) = ADP + phosphate + glutathione S-conjugate(out)." [GOC:jl, PMID:1455517] synonym: "ATP-dependent glutathione S-conjugate export pump" EXACT [] synonym: "conjugate transporter activity" BROAD [] synonym: "GS-X pump" EXACT [] synonym: "MRP1/GS-X pump" EXACT [] is_a: GO:0071997 ! glutathione S-conjugate-transporting ATPase activity [Term] id: GO:0015432 name: bile acid-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O = bile acid(out) + ADP + phosphate." [TC:3.A.1.207.2] synonym: "bile acid porter activity" NARROW [] xref: Reactome:23506 "bile acid-exporting ATPase activity" is_a: GO:0015125 ! bile acid transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015433 name: peptide antigen-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate." [TC:3.A.1.209.1] synonym: "major histocompatibility peptide transporter activity" EXACT [] synonym: "peptide antigen ABC transporter" NARROW [] synonym: "peptide antigen transporter activity" BROAD [] is_a: GO:0015440 ! peptide-transporting ATPase activity [Term] id: GO:0015434 name: cadmium-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)." [EC:3.6.3.46] subset: gosubset_prok synonym: "ATP phosphohydrolase (heavy-metal-exporting)" EXACT [EC:3.6.3.46] synonym: "cadmium ABC transporter" NARROW [] synonym: "yeast cadmium factor" RELATED [EC:3.6.3.46] xref: EC:3.6.3.46 xref: MetaCyc:3.6.3.46-RXN is_a: GO:0015086 ! cadmium ion transmembrane transporter activity [Term] id: GO:0015435 name: ABC-type efflux permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0015436 name: capsular-polysaccharide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)." [EC:3.6.3.38] subset: gosubset_prok synonym: "ATP phosphohydrolase (capsular-polysaccharide-exporting)" EXACT [EC:3.6.3.38] synonym: "capsular-polysaccharide ABC transporter" NARROW [] xref: EC:3.6.3.38 xref: MetaCyc:3.6.3.38-RXN is_a: GO:0015161 ! capsular polysaccharide transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015437 name: lipopolysaccharide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipopolysaccharide(in) = ADP + phosphate + lipopolysaccharide(out)." [EC:3.6.3.39] subset: gosubset_prok synonym: "ATP phosphohydrolase (lipopolysaccharide-exporting)" EXACT [EC:3.6.3.39] synonym: "lipopolysaccharide ABC transporter" NARROW [] synonym: "LPS-transporting ATPase activity" EXACT [] xref: EC:3.6.3.39 xref: MetaCyc:3.6.3.39-RXN is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015438 name: teichoic-acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:3.6.3.40] subset: gosubset_prok synonym: "ATP phosphohydrolase (teichoic-acid-exporting)" EXACT [EC:3.6.3.40] synonym: "teichoic-acid ABC transporter" NARROW [] xref: EC:3.6.3.40 xref: MetaCyc:3.6.3.40-RXN is_a: GO:0015162 ! teichoic acid transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015439 name: heme-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41] subset: gosubset_prok synonym: "ATP phosphohydrolase (heme-exporting)" EXACT [EC:3.6.3.41] synonym: "haem-transporting ATPase activity" EXACT [] synonym: "heme ABC transporter" NARROW [] xref: EC:3.6.3.41 xref: MetaCyc:3.6.3.41-RXN is_a: GO:0015232 ! heme transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015440 name: peptide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43] subset: gosubset_prok synonym: "ATP phosphohydrolase (peptide-exporting)" EXACT [EC:3.6.3.43] synonym: "peptide ABC transporter" NARROW [] xref: EC:3.6.3.43 xref: MetaCyc:3.6.3.43-RXN is_a: GO:0015197 ! peptide transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015441 name: beta-glucan-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)." [EC:3.6.3.42] synonym: "ATP phosphohydrolase (beta-glucan-exporting)" EXACT [EC:3.6.3.42] synonym: "beta-glucan ABC transporter" NARROW [] xref: EC:3.6.3.42 xref: MetaCyc:3.6.3.42-RXN is_a: GO:0015160 ! beta-glucan transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015442 name: hydrogen-/sodium-translocating ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out)." [TC:3.A.2.-.-] comment: This term was made obsolete because it is a redundant grouping term based on a TC-DB classification. synonym: "proton-/sodium-translocating ATPase activity" EXACT [] is_obsolete: true consider: GO:0008553 consider: GO:0008554 [Term] id: GO:0015443 name: sodium-transporting two-sector ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out)." [EC:3.6.3.15] comment: This term was made obsolete because it refers to a bifunctional gene product. is_obsolete: true consider: GO:0046932 consider: GO:0046962 [Term] id: GO:0015444 name: magnesium-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in)." [EC:3.6.3.2] subset: gosubset_prok synonym: "ATP phosphohydrolase (Mg2+-importing)" EXACT [EC:3.6.3.2] synonym: "magnesium importing ATPase activity" EXACT [] synonym: "magnesium-translocating P-type ATPase activity" RELATED [EC:3.6.3.2] synonym: "Mg(2+)-importing ATPase activity" EXACT [EC:3.6.3.2] synonym: "Mg2+-importing ATPase activity" EXACT [EC:3.6.3.2] synonym: "mg2+-importing ATPase activity" EXACT [EC:3.6.3.2] xref: EC:3.6.3.2 xref: MetaCyc:3.6.3.2-RXN is_a: GO:0015095 ! magnesium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0015445 name: silver-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) = ADP + phosphate + Ag+(out)." [EC:3.6.3.53] subset: gosubset_prok synonym: "Ag+-exporting ATPase activity" EXACT [EC:3.6.3.53] synonym: "ATP phosphohydrolase (Ag+-exporting)" EXACT [EC:3.6.3.53] synonym: "silver exporting ATPase activity" EXACT [] xref: EC:3.6.3.53 xref: MetaCyc:3.6.3.53-RXN is_a: GO:0015080 ! silver ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0015446 name: arsenite-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)." [EC:3.6.3.16] subset: gosubset_prok synonym: "arsenical pump-driving ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenical resistance ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenical resistance efflux pump" EXACT [] synonym: "arsenite ABC transporter" NARROW [] synonym: "arsenite transporting ATPase activity" EXACT [] synonym: "arsenite-translocating ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenite-transporting ATPase activity" EXACT [EC:3.6.3.16] synonym: "ATP phosphohydrolase (arsenite-exporting) activity" EXACT [EC:3.6.3.16] xref: EC:3.6.3.16 xref: MetaCyc:3.6.3.16-RXN is_a: GO:0008490 ! arsenite secondary active transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity [Term] id: GO:0015447 name: type II protein secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. is_obsolete: true [Term] id: GO:0015448 name: type III protein (virulence-related) secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. is_obsolete: true [Term] id: GO:0015449 name: type IV protein (DNA-protein) secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. is_obsolete: true [Term] id: GO:0015450 name: P-P-bond-hydrolysis-driven protein transmembrane transporter activity namespace: molecular_function def: "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "protein translocase activity" EXACT [] is_a: GO:0008320 ! protein transmembrane transporter activity is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity [Term] id: GO:0015451 name: decarboxylation-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-] subset: gosubset_prok synonym: "Decarboxylation-driven transporters" RELATED [] xref: TC:3.B is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015452 name: methyl transfer-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-] synonym: "Methyltransfer-driven transporters" EXACT [] xref: TC:3.C is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015453 name: oxidoreduction-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-] subset: gosubset_prok synonym: "Oxidoreduction-driven transporters" EXACT [] xref: TC:3.D is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015454 name: light-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-] synonym: "Light absorption-driven transporters" EXACT [] synonym: "light-driven pumps" EXACT [] xref: TC:3.E is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015459 name: potassium channel regulator activity namespace: molecular_function def: "Modulates the activity of a potassium channel." [GOC:mah] is_a: GO:0016247 ! channel regulator activity [Term] id: GO:0015461 name: endosomal oligosaccharide transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0005768 consider: GO:0015157 [Term] id: GO:0015462 name: protein-transmembrane transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)." [EC:3.6.1.3, GOC:jl] synonym: "pilin/fimbrilin exporter activity" NARROW [] synonym: "protein ABC transporter" NARROW [] synonym: "protein-transporting ATPase activity" EXACT [] is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015464 name: acetylcholine receptor activity namespace: molecular_function def: "Combining with acetylcholine to initiate a change in cell activity." [GOC:jl] is_a: GO:0004888 ! transmembrane receptor activity is_a: GO:0030594 ! neurotransmitter receptor activity is_a: GO:0042166 ! acetylcholine binding [Term] id: GO:0015465 name: lysin activity namespace: molecular_function def: "OBSOLETE. An agent that can lyse cells." [ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0019835 [Term] id: GO:0015466 name: autolysin activity namespace: molecular_function def: "OBSOLETE. An agent that can lyse the cell in which it is synthesized." [GOC:ma] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0019835 [Term] id: GO:0015467 name: G-protein activated inward rectifier potassium channel activity namespace: molecular_function alt_id: GO:0015273 def: "Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah] synonym: "G protein activated inward rectifier potassium channel activity" EXACT [] synonym: "G protein enhanced inward rectifier potassium channel activity" EXACT [] synonym: "G-protein enhanced inward rectifier potassium channel activity" EXACT [] synonym: "G-protein-activated inward rectifier potassium channel activity" EXACT [] synonym: "G-protein-enhanced inward rectifier potassium channel activity" EXACT [] xref: Reactome:23599 "G-protein activated inward rectifier potassium channel activity" is_a: GO:0005242 ! inward rectifier potassium channel activity [Term] id: GO:0015468 name: colicin namespace: molecular_function def: "OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it." [TC:1.C.1.-.-] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0005102 consider: GO:0005198 consider: GO:0009405 consider: GO:0019835 consider: GO:0046930 consider: GO:0046931 consider: GO:0050827 [Term] id: GO:0015469 name: channel-forming toxin activity namespace: molecular_function def: "OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell." [GOC:ai] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0009405 consider: GO:0015267 consider: GO:0046930 consider: GO:0046931 consider: GO:0050827 [Term] id: GO:0015470 name: bacteriocin activity namespace: molecular_function def: "OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0005102 consider: GO:0019835 [Term] id: GO:0015471 name: nucleoside-specific channel forming porin activity namespace: molecular_function def: "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015472 name: fimbrium-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function." [GOC:jl, GOC:rb, PMID:7906046] comment: This term was made obsolete because it refers to a class of proteins and a biological process rather than a molecular function. is_obsolete: true consider: GO:0009297 consider: GO:0030674 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0015473 name: fimbrial usher porin activity namespace: molecular_function def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-] is_a: GO:0015288 ! porin activity [Term] id: GO:0015474 name: autotransporter activity namespace: molecular_function def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-] subset: gosubset_prok is_a: GO:0008565 ! protein transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015475 name: adhesin autotransporter activity namespace: molecular_function def: "Catalysis of the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015474 ! autotransporter activity [Term] id: GO:0015476 name: hemaglutinin autotransporter activity namespace: molecular_function def: "Catalysis of the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015474 ! autotransporter activity [Term] id: GO:0015477 name: receptor porin activity namespace: molecular_function def: "OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.13.-.-] comment: This term was made obsolete because it combines two functions that are not linked. is_obsolete: true [Term] id: GO:0015478 name: oligosaccharide transporting porin activity namespace: molecular_function def: "Catalysis of the transfer of oligosaccharide, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] synonym: "raffinose porin" NARROW [] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015479 name: outer membrane exporter porin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0009279 consider: GO:0015288 [Term] id: GO:0015480 name: secretin (sensu Bacteria) namespace: molecular_function def: "OBSOLETE. Secretins are Gram-negative bacterial outer membrane proteins that form multimeric pores through which macromolecules, usually proteins, can pass. Form homomultimeric ring structures, 10-20 subunits per complex, with large central pores (inner diameters of 5-10 nm)." [TC:1.B.22.-.-] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0008565 consider: GO:0045203 [Term] id: GO:0015481 name: maltose transporting porin activity namespace: molecular_function def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] subset: gosubset_prok synonym: "maltoporin" EXACT [] xref: Wikipedia:Maltoporin is_a: GO:0005363 ! maltose transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015482 name: voltage-gated anion channel porin activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it wrongly combines voltage-gated anion channel activity and porin activity. synonym: "voltage-dependent anion channel porin activity" EXACT [] is_obsolete: true [Term] id: GO:0015483 name: long-chain fatty acid transporting porin activity namespace: molecular_function def: "Catalysis of the transfer of long-chain fatty acids from one side of the membrane to the other. Long-chain fatty acids have a chain length of greater than 12 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0005324 ! long-chain fatty acid transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015484 name: hemolysin activity namespace: molecular_function def: "OBSOLETE. Any substance that causes the lysis of red blood cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0019836 [Term] id: GO:0015485 name: cholesterol binding namespace: molecular_function def: "Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0032934 ! sterol binding [Term] id: GO:0015486 name: glycoside-pentoside-hexuronide:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-] is_a: GO:0005402 ! cation:sugar symporter activity [Term] id: GO:0015487 name: melibiose:monovalent cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)." [TC:2.A.2.1.1] subset: gosubset_prok synonym: "melibiose permease activity" RELATED [] is_a: GO:0015156 ! melibiose transmembrane transporter activity is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity [Term] id: GO:0015488 name: glucuronide:monovalent cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1] synonym: "glucuronoside permease activity" RELATED [] is_a: GO:0015164 ! glucuronoside transmembrane transporter activity is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity [Term] id: GO:0015489 name: putrescine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of putrescine from one side of the membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] subset: gosubset_prok is_a: GO:0015203 ! polyamine transmembrane transporter activity [Term] id: GO:0015490 name: cadaverine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cadaverine, 1,5-pentanediamine, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0015491 name: cation:cation antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai] subset: gosubset_prok is_a: GO:0015298 ! solute:cation antiporter activity [Term] id: GO:0015492 name: phenylalanine:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1] synonym: "phenylalanine:proton symporter activity" EXACT [] is_a: GO:0015192 ! L-phenylalanine transmembrane transporter activity is_a: GO:0015494 ! aromatic amino acid:hydrogen symporter activity [Term] id: GO:0015493 name: lysine:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2] synonym: "lysine:proton symporter activity" EXACT [] is_a: GO:0005280 ! hydrogen:amino acid symporter activity is_a: GO:0015189 ! L-lysine transmembrane transporter activity [Term] id: GO:0015494 name: aromatic amino acid:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3] synonym: "aromatic amino acid:proton symporter activity" EXACT [] is_a: GO:0005280 ! hydrogen:amino acid symporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity [Term] id: GO:0015495 name: gamma-aminobutyric acid:hydrogen symporter activity namespace: molecular_function alt_id: GO:0005331 alt_id: GO:0015329 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2] comment: See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'. synonym: "4-aminobutanoate:hydrogen symporter activity" EXACT [] synonym: "4-aminobutanoate:proton symporter activity" EXACT [] synonym: "4-aminobutyrate:hydrogen symporter activity" EXACT [] synonym: "4-aminobutyrate:proton symporter activity" EXACT [] synonym: "GABA:hydrogen symporter activity" EXACT [] synonym: "GABA:proton symporter activity" EXACT [] synonym: "gamma-aminobutyric acid permease activity" EXACT [] synonym: "gamma-aminobutyric acid:proton symporter activity" EXACT [] is_a: GO:0005280 ! hydrogen:amino acid symporter activity is_a: GO:0015185 ! L-gamma-aminobutyric acid transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015496 name: putrescine:ornithine antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)." [TC:2.A.3.2.1] subset: gosubset_prok synonym: "putrescine-ornithine antiporter activity" EXACT [] synonym: "putrescine/ornithine antiporter activity" EXACT [] synonym: "putrescine:hydrogen symporter activity" EXACT [] is_a: GO:0000064 ! L-ornithine transmembrane transporter activity is_a: GO:0015300 ! solute:solute antiporter activity is_a: GO:0015489 ! putrescine transmembrane transporter activity [Term] id: GO:0015498 name: pantothenate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1] subset: gosubset_prok is_a: GO:0015233 ! pantothenate transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015499 name: formate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai] subset: gosubset_prok is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0015500 name: threonine/serine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in)." [TC:2.A.23.4.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005283 consider: GO:0015194 consider: GO:0015195 [Term] id: GO:0015501 name: glutamate:sodium symporter activity namespace: molecular_function alt_id: GO:0008027 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1] synonym: "sodium/excitatory glutamate cotransporter activity" BROAD [] synonym: "sodium/excitatory glutamate symporter activity" EXACT [] is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0005313 ! L-glutamate transmembrane transporter activity [Term] id: GO:0015503 name: glutathione-regulated potassium exporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2] subset: gosubset_prok is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015504 name: cytosine:hydrogen ion symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1] synonym: "cytosine permease activity" RELATED [] is_a: GO:0015209 ! cytosine transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015391 ! nucleobase:cation symporter activity [Term] id: GO:0015505 name: uracil:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [GOC:mtg_transport] subset: gosubset_prok synonym: "uracil permease activity" RELATED [] is_a: GO:0015210 ! uracil transmembrane transporter activity is_a: GO:0015391 ! nucleobase:cation symporter activity [Term] id: GO:0015506 name: nucleoside:hydrogen symporter activity namespace: molecular_function alt_id: GO:0015536 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)." [TC:2.A.1.10.1, TC:2.A.41.1.1] synonym: "nucleoside permease activity" RELATED [] synonym: "nucleoside:hydrogen ion symporter activity" EXACT [] synonym: "nucleoside:proton symporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity [Term] id: GO:0015507 name: hydroxy/aromatic amino acid permease activity namespace: molecular_function def: "OBSOLETE. Permease for hydroxy and aromatic amino acids." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. is_obsolete: true consider: GO:0015171 consider: GO:0015173 [Term] id: GO:0015513 name: nitrite uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrite from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "nitrite uptake permease activity" EXACT [] is_a: GO:0015113 ! nitrite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015563 ! uptake transmembrane transporter activity [Term] id: GO:0015514 name: nitrite efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "nitrite extrusion permease activity" EXACT [] is_a: GO:0015113 ! nitrite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0015515 name: citrate:succinate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2] subset: gosubset_prok is_a: GO:0015137 ! citrate transmembrane transporter activity is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015516 name: tartrate:succinate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3] is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015554 ! tartrate transmembrane transporter activity [Term] id: GO:0015517 name: galactose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9] subset: gosubset_prok synonym: "galactose:proton symporter activity" EXACT [] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] is_a: GO:0005354 ! galactose transmembrane transporter activity is_a: GO:0009679 ! hexose:hydrogen symporter activity [Term] id: GO:0015518 name: arabinose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)." [TC:2.A.1.1.2] synonym: "arabinose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0042900 ! arabinose transmembrane transporter activity [Term] id: GO:0015519 name: D-xylose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3] subset: gosubset_prok synonym: "D-xylose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0015148 ! D-xylose transmembrane transporter activity [Term] id: GO:0015520 name: tetracycline:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)." [TC:2.A.1.2.4] subset: gosubset_prok synonym: "tetracyclin:hydrogen antiporter activity" EXACT [] synonym: "tetracyclin:proton antiporter activity" EXACT [] synonym: "tetracycline:proton antiporter activity" EXACT [] is_a: GO:0008493 ! tetracycline transporter activity is_a: GO:0015307 ! drug:hydrogen antiporter activity [Term] id: GO:0015521 name: bicyclomycin/sulfathiazole:hydrogen antiporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in)." [TC:2.A.1.2.7] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "bicyclomycin/sulfathiazole:proton antiporter activity" EXACT [] synonym: "bicyclomycin/sulphathiazole:hydrogen antiporter activity" EXACT [] is_obsolete: true consider: GO:0015545 consider: GO:0015546 consider: GO:0045119 [Term] id: GO:0015522 name: hydrophobic uncoupler:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS." [TC:2.A.1.2.9] synonym: "hydrophobic uncoupler:proton antiporter activity" EXACT [] is_a: GO:0015307 ! drug:hydrogen antiporter activity is_a: GO:0017077 ! oxidative phosphorylation uncoupler activity [Term] id: GO:0015523 name: arabinose efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arabinose from the inside of the cell to the outside of the cell across a membrane: H+(out) + arabinose(in) = H+(in) + arabinose(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.2.14] synonym: "arabinose efflux permease activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity is_a: GO:0042900 ! arabinose transmembrane transporter activity [Term] id: GO:0015524 name: L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out)." [TC:2.A.1.2.15] comment: This term was made obsolete because it represents a gene product rather than a single discrete molecular function. synonym: "L-arabinose/beta-D-thiogalactopyranoside:proton antiporter activity" EXACT [] is_obsolete: true consider: GO:0015147 consider: GO:0015299 consider: GO:0051119 [Term] id: GO:0015525 name: carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:proton antiporter activity" EXACT [] is_obsolete: true replaced_by: GO:0015307 replaced_by: GO:0015547 replaced_by: GO:0015548 replaced_by: GO:0015549 [Term] id: GO:0015526 name: hexose-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.1] is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity [Term] id: GO:0015527 name: glycerol-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3] is_a: GO:0015168 ! glycerol transmembrane transporter activity is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity [Term] id: GO:0015528 name: lactose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] synonym: "lactose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0015155 ! lactose transmembrane transporter activity [Term] id: GO:0015529 name: raffinose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2] synonym: "raffinose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0015158 ! raffinose transmembrane transporter activity [Term] id: GO:0015530 name: shikimate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of shikimate from one side of the membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:ai] subset: gosubset_prok is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0015531 name: citrate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1] synonym: "citrate:proton symporter activity" EXACT [] is_a: GO:0015137 ! citrate transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity [Term] id: GO:0015532 name: alpha-ketoglutarate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)." [TC:2.A.1.6.2] subset: gosubset_prok synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT [] synonym: "2-oxoglutarate:proton symporter activity" EXACT [] synonym: "alpha-ketoglutarate:proton symporter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015533 name: shikimate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6] synonym: "shikimate:proton symporter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015296 ! anion:cation symporter activity is_a: GO:0015530 ! shikimate transmembrane transporter activity [Term] id: GO:0015534 name: proline/glycine/betaine:hydrogen/sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in)." [TC:2.A.1.6.4] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "proline/glycine/betaine:proton/sodium symporter" EXACT [] is_obsolete: true consider: GO:0015187 consider: GO:0015193 consider: GO:0015199 consider: GO:0015294 consider: GO:0015295 consider: GO:0015370 [Term] id: GO:0015535 name: fucose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)." [TC:2.A.1.7.1] synonym: "fucose:proton symporter activity" EXACT [] is_a: GO:0009679 ! hexose:hydrogen symporter activity is_a: GO:0015150 ! fucose transmembrane transporter activity [Term] id: GO:0015537 name: xanthosine:hydrogen ion symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2] synonym: "xanthosine permease activity" RELATED [] is_a: GO:0015506 ! nucleoside:hydrogen symporter activity is_a: GO:0015553 ! xanthosine transmembrane transporter activity [Term] id: GO:0015538 name: sialic acid:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)." [TC:2.A.1.12.1] subset: gosubset_prok synonym: "sialic acid permease activity" RELATED [] xref: Reactome:24033 "sialic acid:hydrogen symporter activity" is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0015136 ! sialic acid transmembrane transporter activity [Term] id: GO:0015539 name: hexuronate:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate." [TC:2.A.1.14.2] synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW [] synonym: "hexuronate porter activity" RELATED [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0015134 ! hexuronate transmembrane transporter activity [Term] id: GO:0015540 name: 3-hydroxyphenyl propionate:hydrogen ion symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2] synonym: "3-hydroxyphenyl propionate porter activity" RELATED [] is_a: GO:0015293 ! symporter activity is_a: GO:0015551 ! 3-hydroxyphenyl propanoate transmembrane transporter activity [Term] id: GO:0015541 name: secondary active cyanate uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cyanate(out) = cyanate(in)." [TC:2.A.1.17.1] synonym: "cyanate porter activity" RELATED [] is_a: GO:0015110 ! cyanate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015542 name: sugar efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(in) = sugar(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.20.1] subset: gosubset_prok synonym: "lactose/glucose efflux transporter activity" NARROW [] is_a: GO:0005351 ! sugar:hydrogen symporter activity [Term] id: GO:0015543 name: lactose/glucose efflux transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out)." [TC:2.A.1.20.2] comment: This term was made obsolete because it represents two molecular functions. is_obsolete: true consider: GO:0005355 consider: GO:0015155 consider: GO:0015542 [Term] id: GO:0015544 name: phenyl propionate uptake uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenyl propionate(out) = phenyl propionate(in)." [GOC:mtg_transport, TC:2.A.1.27.1] synonym: "phenyl propionate permease activity" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015552 ! propionate transmembrane transporter activity [Term] id: GO:0015545 name: bicyclomycin transporter activity namespace: molecular_function def: "Enables the directed movement of bicyclomycin into, out of or within a cell, or between cells. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X] subset: gosubset_prok synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED [] is_a: GO:0042895 ! antibiotic transporter activity [Term] id: GO:0015546 name: sulfathiazole transporter activity namespace: molecular_function def: "Enables the directed movement of sulfathiazole into, out of or within a cell, or between cells. Sulfathiazole is an antibacterial agent of the sulfonamide group." [CHEBI:9337, GOC:curators] synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED [] synonym: "sulphathiazole transporter activity" EXACT [] is_a: GO:0045118 ! azole transporter activity [Term] id: GO:0015547 name: nalidixic acid transporter activity namespace: molecular_function def: "Enables the directed movement of nalidixic acid into, out of or within a cell, or between cells. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED [] is_a: GO:0042895 ! antibiotic transporter activity is_a: GO:0042910 ! xenobiotic transporter activity [Term] id: GO:0015548 name: organomercurial transporter activity namespace: molecular_function def: "Enables the directed movement of organomercurial compounds into, out of or within a cell, or between cells. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED [] is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015549 name: carbonyl cyanide m-chlorophenylhydrazone transporter activity namespace: molecular_function def: "Enables the directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [CHEBI:3259, GOC:curators] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED [] synonym: "CCCP transporter activity" EXACT [] is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015550 name: galacturonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of galacturonate from one side of the membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] is_a: GO:0015134 ! hexuronate transmembrane transporter activity [Term] id: GO:0015551 name: 3-hydroxyphenyl propanoate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of 3-hydroxyphenyl propanoate from one side of the membrane to the other." [GOC:ai] synonym: "3-hydroxyphenyl propionate transmembrane transporter activity" EXACT [] is_a: GO:0015552 ! propionate transmembrane transporter activity [Term] id: GO:0015552 name: propionate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of propionate from one side of the membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0015553 name: xanthosine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity [Term] id: GO:0015554 name: tartrate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tartrate from one side of the membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria." [GOC:ai] subset: gosubset_prok is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0042876 ! aldarate transmembrane transporter activity [Term] id: GO:0015556 name: C4-dicarboxylate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of C4-dicarboxylate from one side of the membrane to the other." [GOC:krc] subset: gosubset_prok is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0015557 name: arginine targeting transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of fully folded proteins into, out of or within a cell, or between cells, by targeting the proteins to the transporter via a specialized N-terminal twin arginine signal peptide." [GOC:dph, GOC:tb, PMID:17956229] is_a: GO:0008565 ! protein transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015558 name: p-aminobenzoyl-glutamate uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of p-aminobenzoyl-glutamate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "p-aminobenzoyl-glutamate uptake permease activity" EXACT [] is_a: GO:0015563 ! uptake transmembrane transporter activity is_a: GO:0015569 ! p-aminobenzoyl-glutamate transmembrane transporter activity [Term] id: GO:0015560 name: L-idonate/D-gluconate:hydrogen symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in)." [TC:2.A.8.1.2] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "L-idonate/D-gluconate:proton symporter" EXACT [] is_obsolete: true consider: GO:0015128 consider: GO:0015295 consider: GO:0015568 [Term] id: GO:0015561 name: rhamnose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)." [TC:2.A.7.6.1] synonym: "rhamnose:proton symporter activity" EXACT [] is_a: GO:0009679 ! hexose:hydrogen symporter activity is_a: GO:0015153 ! rhamnose transmembrane transporter activity [Term] id: GO:0015562 name: efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "efflux permease activity" EXACT [] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015563 name: uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a specific substance or related group of substances from the outside of a cell to the inside across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "cobalt, zinc uptake permease activity" RELATED [] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] synonym: "uptake permease activity" RELATED [] synonym: "zinc, cadmium uptake permease activity" NARROW [] synonym: "zinc, iron permease activity" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015565 name: threonine efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of threonine from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "threonine efflux permease activity" EXACT [] synonym: "threonine export protein" RELATED [] synonym: "threonine export transporter activity" EXACT [] is_a: GO:0015195 ! L-threonine transmembrane transporter activity is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity [Term] id: GO:0015566 name: acriflavine transporter activity namespace: molecular_function alt_id: GO:0015555 def: "Enables the directed movement of acriflavin into, out of or within a cell, or between cells. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [PubChem_Compound:6842] synonym: "acriflavin resistant pump activity" RELATED [GOC:dph, GOC:tb] synonym: "acriflavin transporter activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transporter activity [Term] id: GO:0015567 name: alkane transporter activity namespace: molecular_function def: "Enables the directed movement of alkanes into, out of or within a cell, or between cells. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015568 name: L-idonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-idonate from one side of the membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai] subset: gosubset_prok synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042879 ! aldonate transmembrane transporter activity [Term] id: GO:0015569 name: p-aminobenzoyl-glutamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid." [GOC:ai] subset: gosubset_prok synonym: "p-aminobenzoyl-glutamate transporter activity" BROAD [] is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015571 name: N-acetylgalactosamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015590 def: "Catalysis of the transfer of N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "N-acetylgalactosamine permease activity" EXACT [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015572 name: N-acetylglucosamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015580 def: "Catalysis of the transfer of N-acetylglucosamine from one side of the membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-GlcNAc transmembrane transporter activity" EXACT [] synonym: "N-Acetyl-D-glucosamine permease" RELATED [] synonym: "N-acetyl-D-glucosamine transmembrane transporter activity" EXACT [] synonym: "N-acetylchitosamine transmembrane transporter activity" EXACT [] synonym: "N-acetylglucosamine permease activity" RELATED [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015573 name: beta-glucoside transmembrane transporter activity namespace: molecular_function alt_id: GO:0015582 def: "Catalysis of the transfer of beta-glucosides from one side of the membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "beta-glucoside permease activity" EXACT [] is_a: GO:0042947 ! glucoside transmembrane transporter activity [Term] id: GO:0015574 name: trehalose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015584 def: "Catalysis of the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "trehalose permease activity" EXACT [] is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0015575 name: mannitol transmembrane transporter activity namespace: molecular_function alt_id: GO:0015586 def: "Catalysis of the transfer of mannitol from one side of the membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "mannitol permease activity" EXACT [] is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015576 name: sorbitol transmembrane transporter activity namespace: molecular_function alt_id: GO:0015587 def: "Catalysis of the transfer of sorbitol from one side of the membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucitol permease activity" EXACT [] synonym: "glucitol transporter activity" EXACT [] synonym: "sorbitol permease activity" EXACT [] is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015577 name: galactitol transmembrane transporter activity namespace: molecular_function alt_id: GO:0015588 def: "Catalysis of the transfer of a galactitol from one side of the membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "galactitol permease activity" EXACT [] is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015578 name: mannose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015589 def: "Catalysis of the transfer of mannose from one side of the membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "mannose permease activity" EXACT [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015583 name: beta-glucoside [arbutin-salicin-cellobiose] permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it arbitrarily groups three substrates. is_obsolete: true [Term] id: GO:0015591 name: D-ribose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-ribose from one side of the membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok is_a: GO:0015146 ! pentose transmembrane transporter activity [Term] id: GO:0015592 name: methylgalactoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of methylgalactoside from one side of the membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [CHEBI:55507, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015593 name: allose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of allose from one side of the membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015594 name: putrescine-importing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + putrescine(out) = ADP + phosphate + putrescine(in)." [EC:3.6.3.31] synonym: "putrescine porter activity" BROAD [] is_a: GO:0015417 ! polyamine-transporting ATPase activity is_a: GO:0015489 ! putrescine transmembrane transporter activity [Term] id: GO:0015595 name: spermidine-importing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + spermidine(out) = ADP + phosphate + spermidine(in)." [EC:3.6.3.31] synonym: "spermidine porter activity" BROAD [] is_a: GO:0015417 ! polyamine-transporting ATPase activity is_a: GO:0015606 ! spermidine transmembrane transporter activity [Term] id: GO:0015596 name: glycine betaine/proline porter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32, TC:3.A.1.12.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0015187 consider: GO:0015193 consider: GO:0015199 consider: GO:0015418 [Term] id: GO:0015597 name: histidine/arginine/lysine/ornithine porter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0000064 consider: GO:0005290 consider: GO:0015181 consider: GO:0015189 consider: GO:0015426 [Term] id: GO:0015598 name: arginine-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arginine(out) = ADP + phosphate + arginine(in)." [EC:3.6.3.21] subset: gosubset_prok synonym: "arginine porter activity" EXACT [] is_a: GO:0015181 ! arginine transmembrane transporter activity is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity [Term] id: GO:0015599 name: glutamine-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) = ADP + phosphate + glutamine(in)." [EC:3.6.3.21] subset: gosubset_prok synonym: "glutamine porter activity" BROAD [] is_a: GO:0015186 ! L-glutamine transmembrane transporter activity is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity [Term] id: GO:0015600 name: glutamate/aspartate porter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.4] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005313 consider: GO:0015183 consider: GO:0015426 [Term] id: GO:0015601 name: cystine/diaminopimelate porter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.10] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0015184 consider: GO:0015426 consider: GO:0015626 [Term] id: GO:0015602 name: leucine/isoleucine/valine porter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22, TC:3.A.1.4.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005304 consider: GO:0015188 consider: GO:0015190 consider: GO:0015425 [Term] id: GO:0015603 name: iron chelate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com] subset: gosubset_prok is_a: GO:0005381 ! iron ion transmembrane transporter activity [Term] id: GO:0015604 name: phosphonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphonate from one side of a membrane to the other. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:ai] subset: gosubset_prok is_a: GO:0008514 ! organic anion transmembrane transporter activity [Term] id: GO:0015605 name: organophosphate ester transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] is_a: GO:0008514 ! organic anion transmembrane transporter activity [Term] id: GO:0015606 name: spermidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of the membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0015203 ! polyamine transmembrane transporter activity [Term] id: GO:0015607 name: fatty-acyl-CoA transporter activity namespace: molecular_function def: "Enables the directed movement of a fatty acyl CoA group into, out of or within a cell, or between cells. A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it." [GOC:ai] synonym: "fatty acyl CoA transporter activity" EXACT [GOC:curators] is_a: GO:0015246 ! fatty-acyl group transporter activity [Term] id: GO:0015608 name: carbohydrate-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) = ADP + phosphate + carbohydrate(in)." [GOC:ai, TC:3.A.1.1.-, TC:3.A.1.2.-] subset: gosubset_prok synonym: "carbohydrate uptake transporter activity" EXACT [] synonym: "sugar transporter" NARROW [] is_a: GO:0043211 ! carbohydrate-transporting ATPase activity [Term] id: GO:0015609 name: maltooligosaccharide-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltooligosaccharide(out) = ADP + phosphate + maltooligosaccharide(in)." [TC:3.A.1.-.-] synonym: "maltooligosaccharide porter activity" BROAD [] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015610 name: glycerol phosphate-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-phosphate(out) = ADP + phosphate + glycerol-phosphate(in)." [TC:3.A.1.-.-] synonym: "glycerol-phosphate porter activity" BROAD [] is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015611 name: D-ribose-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) = ADP + phosphate + D-ribose(in)." [TC:3.A.1.-.-] subset: gosubset_prok synonym: "D-ribose porter activity" BROAD [] is_a: GO:0015407 ! monosaccharide-transporting ATPase activity is_a: GO:0015591 ! D-ribose transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015612 name: L-arabinose-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) = ADP + phosphate + L-arabinose(in)." [TC:3.A.1.-.-] synonym: "L-arabinose porter activity" EXACT [] is_a: GO:0015147 ! L-arabinose transmembrane transporter activity is_a: GO:0015407 ! monosaccharide-transporting ATPase activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015613 name: galactose/glucose (methylgalactoside) porter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005354 consider: GO:0005355 consider: GO:0015291 consider: GO:0015592 [Term] id: GO:0015614 name: D-xylose-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in)." [TC:3.A.1.-.-] synonym: "D-xylose porter activity" BROAD [] is_a: GO:0015148 ! D-xylose transmembrane transporter activity is_a: GO:0015407 ! monosaccharide-transporting ATPase activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015615 name: D-allose-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) = ADP + phosphate + D-allose(in)." [TC:3.A.1.-.-] synonym: "D-allose porter activity" BROAD [] is_a: GO:0015407 ! monosaccharide-transporting ATPase activity is_a: GO:0015593 ! allose transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015616 name: DNA translocase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule." [GOC:mah, PMID:16428451, PMID:17631491] comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. is_a: GO:0003677 ! DNA binding is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0015617 name: pilin/fimbrilin exporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0015462 [Term] id: GO:0015619 name: thiamine pyrophosphate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine pyrophosphate(out) = ADP + phosphate + thiamine pyrophosphate(in)." [TC:3.A.1.19.1] synonym: "thiamin pyrophosphate ABC transporter" NARROW [] synonym: "thiamin pyrophosphate porter activity" BROAD [] synonym: "thiamin pyrophosphate transporting ATPase activity" EXACT [GOC:curators] synonym: "TPP transporting ATPase activity" EXACT [] is_a: GO:0015234 ! thiamine transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015620 name: ferric-enterobactin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric-enterobactin from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0015343 ! siderophore transmembrane transporter activity [Term] id: GO:0015621 name: ferric triacetylfusarinine C transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric triacetylfusarinine C from one side of a membrane to the other." [GOC:ai] is_a: GO:0015091 ! ferric iron transmembrane transporter activity [Term] id: GO:0015622 name: ferric-hydroxamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric-hydroxamate from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0015343 ! siderophore transmembrane transporter activity [Term] id: GO:0015623 name: iron-chelate-transporting ATPase activity namespace: molecular_function alt_id: GO:0015409 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + iron chelate(out) = ADP + phosphate + iron chelate(in). Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores are imported." [EC:3.6.3.34] subset: gosubset_prok synonym: "ATP phosphohydrolase (iron-chelate-importing)" EXACT [EC:3.6.3.34] synonym: "ferric/ferric-dicitrate porter" BROAD [] synonym: "iron-chelate ABC transporter" NARROW [] xref: EC:3.6.3.34 xref: MetaCyc:3.6.3.34-RXN is_a: GO:0015603 ! iron chelate transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015624 name: ferric-enterobactin-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)." [TC:3.A.1.-.-] synonym: "ferric-enterobactin ABC transporter" NARROW [] synonym: "ferric-enterobactin porter activity" BROAD [] is_a: GO:0015620 ! ferric-enterobactin transmembrane transporter activity is_a: GO:0015623 ! iron-chelate-transporting ATPase activity [Term] id: GO:0015625 name: ferric-hydroxamate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)." [TC:3.A.1.-.-] synonym: "ferric-hydroxamate ABC transporter" NARROW [] synonym: "ferric-hydroxamate porter activity" BROAD [] is_a: GO:0015622 ! ferric-hydroxamate transmembrane transporter activity is_a: GO:0015623 ! iron-chelate-transporting ATPase activity [Term] id: GO:0015626 name: L-diaminopimelate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] synonym: "cystine/diaminopimelate porter activity" NARROW [] synonym: "L-diaminopimelate transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015627 name: type II protein secretion system complex namespace: cellular_component def: "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494] comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'. subset: gosubset_prok synonym: "general secretion pathway-associated complex" RELATED [] synonym: "main terminal branch" EXACT [] synonym: "MTB" EXACT [] synonym: "Sec-dependent secretion system-associated complex" RELATED [] synonym: "T2SS-associated complexes" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0015628 name: protein secretion by the type II secretion system namespace: biological_process def: "The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type II protein secretion system complex ; GO:0015627'. This process refers specifically to secretion across the outer membrane. For components of the Sec and Tat pathways, consider annotating to 'protein transport by the Sec complex ; GO:0043952' and 'protein transport by the Tat complex ; GO:0043953'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. subset: gosubset_prok synonym: "protein secretion by the general secretion pathway" RELATED [] synonym: "protein secretion by the general secretory pathway" RELATED [] synonym: "protein secretion by the T2S" EXACT [] synonym: "protein secretion by the T2SS" EXACT [] synonym: "protein secretion by the type II protein secretion system" EXACT [] synonym: "type II protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0015629 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015630 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015631 name: tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0015633 name: zinc transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)." [TC:3.A.1.-.-] synonym: "zinc porter activity" RELATED [] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0015634 name: lipopolysaccharide exporter activity namespace: molecular_function def: "Catalysis of the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:mtg_transport, ISBN:0815340729] synonym: "LPS exporter activity" EXACT [] is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0015635 name: short-chain fatty acid transporter activity namespace: molecular_function def: "Enables the directed movement of short-chain fatty acids into, out of or within a cell, or between cells. Short-chain fatty acids have a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015245 ! fatty acid transporter activity [Term] id: GO:0015636 name: short-chain fatty acid uptake transporter activity namespace: molecular_function def: "Enables the directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids have a chain length of less than 8 carbons." [GOC:mah] is_a: GO:0015635 ! short-chain fatty acid transporter activity [Term] id: GO:0015638 name: microcin uptake transporter activity namespace: molecular_function def: "Catalysis of the transfer of a microcin from the outside of a cell to the inside of the cell across a membrane." [GOC:mah] subset: gosubset_prok synonym: "microcin uptake permease activity" EXACT [] is_a: GO:0015197 ! peptide transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015639 name: ferrous iron uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) + energy = Fe2+(in)." [TC:9.A.8.1.1] subset: gosubset_prok is_a: GO:0015093 ! ferrous iron transmembrane transporter activity [Term] id: GO:0015640 name: peptidoglycan peptide transporter activity namespace: molecular_function def: "Enables the directed movement of peptidoglycan peptides into, out of or within a cell, or between cells. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "murein peptide transporter activity" EXACT [] synonym: "muropeptide transporter activity" EXACT [] is_a: GO:0015197 ! peptide transporter activity is_a: GO:0015647 ! peptidoglycan transporter activity [Term] id: GO:0015641 name: lipoprotein toxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0009405 replaced_by: GO:0050827 [Term] id: GO:0015642 name: bacteriolytic toxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause lysis of bacterial cells." [GOC:jl] comment: This term was made obsolete because it represents a class of gene products and not a molecular function. is_obsolete: true consider: GO:0019835 [Term] id: GO:0015643 name: toxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a toxin, a poisonous substance that causes damage to biological systems. Toxins are differentiated from simple chemical poisons and vegetable alkaloids by their high molecular weight and antigenicity (they elicit an antibody response)." [GOC:curators] synonym: "antitoxin activity" RELATED [] synonym: "lipoprotein antitoxin" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0015644 name: lipoprotein antitoxin namespace: molecular_function def: "OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it." [GOC:jl] comment: This term was made obsolete because it does not represent a function distinct from its parent term. is_obsolete: true replaced_by: GO:0015643 [Term] id: GO:0015645 name: fatty acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [EC:6.2.1.20, EC:6.2.1.3, GOC:cjk, GOC:mah] subset: gosubset_prok synonym: "acid:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.3] synonym: "acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "acyl-coenzyme A ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acid CoA ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "fatty-acid ligase activity" EXACT [] xref: EC:6.2.1.- is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0015647 name: peptidoglycan transporter activity namespace: molecular_function def: "Enables the directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells." [GOC:ai] subset: gosubset_prok synonym: "murein transporter activity" EXACT [] is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0015648 name: lipid-linked peptidoglycan transporter activity namespace: molecular_function def: "Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells." [GOC:mah] synonym: "lipid-linked murein transporter activity" EXACT [] is_a: GO:0015647 ! peptidoglycan transporter activity [Term] id: GO:0015649 name: 2-keto-3-deoxygluconate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)." [TC:2.A.10.1.1] subset: gosubset_prok synonym: "2-keto-3-deoxygluconate:proton symporter activity" EXACT [] is_a: GO:0005402 ! cation:sugar symporter activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015128 ! gluconate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015650 name: lactate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)." [TC:2.A.14.1.1] synonym: "lactate permease" BROAD [] synonym: "lactate:hydrogen porter activity" EXACT [] synonym: "lactate:proton porter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015129 ! lactate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015651 name: quaternary ammonium group transmembrane transporter activity namespace: molecular_function alt_id: GO:0015202 def: "Catalysis of the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "quaternary amine transmembrane transporter activity" EXACT [] synonym: "quaternary ammonium compound transporter activity" EXACT [] is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0015652 name: quaternary ammonium group:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)." [GOC:ai] subset: gosubset_prok synonym: "quaternary ammonium group:proton symporter activity" EXACT [] is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity [Term] id: GO:0015653 name: glycine betaine:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1] subset: gosubset_prok synonym: "glycine betaine:proton symporter activity" EXACT [] is_a: GO:0015199 ! betaine transmembrane transporter activity is_a: GO:0015652 ! quaternary ammonium group:hydrogen symporter activity [Term] id: GO:0015654 name: tellurite uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tellurite from the outside of a cell to the inside across a membrane: tellurite(out) + H+(out) = tellurite(in) + H+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.16.1.1] synonym: "tellurite-resistance uptake permease activity" EXACT [] synonym: "tellurite-resistance uptake transmembrane transporter activity" EXACT [] is_a: GO:0015563 ! uptake transmembrane transporter activity [Term] id: GO:0015655 name: alanine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)." [GOC:ai] subset: gosubset_prok is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0022858 ! alanine transmembrane transporter activity [Term] id: GO:0015657 name: branched-chain amino acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1] is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0015658 ! branched-chain aliphatic amino acid transmembrane transporter activity [Term] id: GO:0015658 name: branched-chain aliphatic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of branched-chain aliphatic amino acids from one side of a membrane to the other. Branched-chain aliphatic amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "branched-chain aliphatic amino acid transporter activity" BROAD [] synonym: "leucine/valine/isoleucine permease activity" RELATED [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015659 name: formate uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of formate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "formate uptake permease activity" EXACT [] is_a: GO:0015499 ! formate transmembrane transporter activity is_a: GO:0015563 ! uptake transmembrane transporter activity [Term] id: GO:0015660 name: formate efflux transmembrane transporter activity namespace: molecular_function alt_id: GO:0015509 def: "Catalysis of the transfer of formate from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "formate efflux permease activity" EXACT [] is_a: GO:0015499 ! formate transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0015661 name: L-lysine efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-lysine exporter activity" EXACT [] synonym: "L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity" EXACT [] is_a: GO:0015189 ! L-lysine transmembrane transporter activity is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity [Term] id: GO:0015662 name: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683] subset: gosubset_prok synonym: "P-type ATPase activity" EXACT [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] xref: Reactome:1393 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions [Term] id: GO:0015663 name: nicotinamide mononucleotide transmembrane transporter activity namespace: molecular_function alt_id: GO:0015664 def: "Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [CHEBI:50383, GOC:curators, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "nicotinamide mononucleotide permease activity" RELATED [] synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0015665 name: alcohol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0015666 name: restriction endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mlg] subset: gosubset_prok synonym: "restriction endonuclease activity" EXACT [] synonym: "restriction enzyme activity" EXACT [] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0015667 name: site-specific DNA-methyltransferase (cytosine-N4-specific) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine." [EC:2.1.1.113] subset: gosubset_prok synonym: "DNA[cytosine-N4]methyltransferase activity" EXACT [EC:2.1.1.113] synonym: "m4C-forming MTase activity" EXACT [EC:2.1.1.113] synonym: "modification methylase activity" RELATED [EC:2.1.1.113] synonym: "N(4)-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] synonym: "N4-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.113] synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" EXACT [EC:2.1.1.113] synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" EXACT [EC:2.1.1.113] xref: EC:2.1.1.113 xref: MetaCyc:2.1.1.113-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity [Term] id: GO:0015668 name: Type III site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites." [EC:3.1.21.5, PMID:12654995] subset: gosubset_prok synonym: "Type III restriction enzyme activity" EXACT [] xref: EC:3.1.21.5 xref: MetaCyc:3.1.21.5-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0015669 name: gas transport namespace: biological_process def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0015670 name: carbon dioxide transport namespace: biological_process def: "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015669 ! gas transport [Term] id: GO:0015671 name: oxygen transport namespace: biological_process def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0015669 ! gas transport [Term] id: GO:0015672 name: monovalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai] subset: gosubset_prok is_a: GO:0006812 ! cation transport [Term] id: GO:0015673 name: silver ion transport namespace: biological_process def: "The directed movement of silver (Ag) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "silver transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0015672 ! monovalent inorganic cation transport [Term] id: GO:0015675 name: nickel ion transport namespace: biological_process def: "The directed movement of nickel (Ni) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0015676 name: vanadium ion transport namespace: biological_process def: "The directed movement of vanadium (V) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0015677 name: copper ion import namespace: biological_process def: "The directed movement of copper ions into a cell or organelle." [GOC:ai] synonym: "copper ion uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0035434 ! copper ion transmembrane transport [Term] id: GO:0015678 name: high-affinity copper ion transport namespace: biological_process def: "The directed, high-affinity movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] synonym: "high affinity copper ion transport" EXACT [] synonym: "high affinity copper transport" EXACT [] is_a: GO:0035434 ! copper ion transmembrane transport [Term] id: GO:0015679 name: plasma membrane copper ion transport namespace: biological_process def: "The directed movement of copper ions across the plasma membrane." [GOC:ai] synonym: "plasma membrane copper transport" EXACT [] is_a: GO:0035434 ! copper ion transmembrane transport [Term] id: GO:0015680 name: intracellular copper ion transport namespace: biological_process def: "The directed movement of copper (Cu) ions within a cell." [GOC:ai] synonym: "intracellular copper delivery" EXACT [] is_a: GO:0006825 ! copper ion transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0015682 name: ferric iron transport namespace: biological_process def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "ferric ion transport" EXACT [] is_a: GO:0006826 ! iron ion transport [Term] id: GO:0015683 name: high-affinity ferric iron transport namespace: biological_process def: "The directed, high-affinity movement of ferric (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] synonym: "high affinity ferric iron transport" EXACT [] is_a: GO:0006827 ! high-affinity iron ion transport is_a: GO:0015682 ! ferric iron transport [Term] id: GO:0015684 name: ferrous iron transport namespace: biological_process def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "ferrous ion transport" EXACT [] is_a: GO:0006826 ! iron ion transport is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0015685 name: ferric-enterobactin transport namespace: biological_process def: "The directed movement of ferric-enterobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0015682 ! ferric iron transport is_a: GO:0042930 ! enterobactin transport [Term] id: GO:0015686 name: ferric triacetylfusarinine C transport namespace: biological_process def: "The directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015682 ! ferric iron transport is_a: GO:0015891 ! siderophore transport [Term] id: GO:0015687 name: ferric-hydroxamate transport namespace: biological_process def: "The directed movement of ferric-hydroxamate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0015682 ! ferric iron transport is_a: GO:0015891 ! siderophore transport is_a: GO:0042886 ! amide transport [Term] id: GO:0015688 name: iron chelate transport namespace: biological_process def: "The directed movement of iron chelates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [GOC:ai] subset: gosubset_prok is_a: GO:0006826 ! iron ion transport [Term] id: GO:0015689 name: molybdate ion transport namespace: biological_process def: "The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid." [GOC:ai] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015690 name: aluminum ion transport namespace: biological_process def: "The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "aluminium ion transport" EXACT [] synonym: "aluminium transport" EXACT [] synonym: "aluminum transport" EXACT [] is_a: GO:0030001 ! metal ion transport is_a: GO:0072512 ! trivalent inorganic cation transport [Term] id: GO:0015691 name: cadmium ion transport namespace: biological_process def: "The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "cadmium transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport [Term] id: GO:0015692 name: lead ion transport namespace: biological_process def: "The directed movement of lead (Pb) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0030001 ! metal ion transport [Term] id: GO:0015693 name: magnesium ion transport namespace: biological_process def: "The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "magnesium transport" RELATED [] is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0015694 name: mercury ion transport namespace: biological_process def: "The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "mercuric ion transport" NARROW [] synonym: "mercury transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport relationship: part_of GO:0050787 ! detoxification of mercury ion [Term] id: GO:0015695 name: organic cation transport namespace: biological_process def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] subset: gosubset_prok is_a: GO:0006812 ! cation transport [Term] id: GO:0015696 name: ammonium transport namespace: biological_process def: "The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ammonia transport" RELATED [] is_a: GO:0015695 ! organic cation transport [Term] id: GO:0015697 name: quaternary ammonium group transport namespace: biological_process alt_id: GO:0015845 def: "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "quaternary amine transport" EXACT [] synonym: "quaternary ammonium compound transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0015837 ! amine transport [Term] id: GO:0015698 name: inorganic anion transport namespace: biological_process def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] subset: gosubset_prok is_a: GO:0006820 ! anion transport [Term] id: GO:0015699 name: antimonite transport namespace: biological_process def: "The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015700 name: arsenite transport namespace: biological_process def: "The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015701 name: bicarbonate transport namespace: biological_process def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] xref: Reactome:1253741 "Bicarbonate transporters" xref: Reactome:1280673 "Bicarbonate transporters" xref: Reactome:1299498 "Bicarbonate transporters" xref: Reactome:1327258 "Bicarbonate transporters" xref: Reactome:1353353 "Bicarbonate transporters" xref: Reactome:1373526 "Bicarbonate transporters" xref: Reactome:1393547 "Bicarbonate transporters" xref: Reactome:1418048 "Bicarbonate transporters" xref: Reactome:1451138 "Bicarbonate transporters" xref: Reactome:1471486 "Bicarbonate transporters" xref: Reactome:1483421 "Bicarbonate transporters" xref: Reactome:425381 "Bicarbonate transporters" is_a: GO:0015698 ! inorganic anion transport is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015702 name: chlorate transport namespace: biological_process def: "The directed movement of chlorate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015703 name: chromate transport namespace: biological_process def: "The directed movement of chromate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015704 name: cyanate transport namespace: biological_process def: "The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015705 name: iodide transport namespace: biological_process def: "The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015706 name: nitrate transport namespace: biological_process alt_id: GO:0006872 def: "The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015707 name: nitrite transport namespace: biological_process def: "The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015708 name: silicate transport namespace: biological_process def: "The directed movement of silicates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015709 name: thiosulfate transport namespace: biological_process def: "The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok synonym: "thiosulphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015710 name: tellurite transport namespace: biological_process def: "The directed movement of tellurite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015711 name: organic anion transport namespace: biological_process def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] subset: gosubset_prok is_a: GO:0006820 ! anion transport [Term] id: GO:0015712 name: hexose phosphate transport namespace: biological_process def: "The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015713 name: phosphoglycerate transport namespace: biological_process def: "The directed movement of phosphoglycerate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport [Term] id: GO:0015714 name: phosphoenolpyruvate transport namespace: biological_process def: "The directed movement of phosphoenolpyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015715 name: nucleotide-sulfate transport namespace: biological_process def: "The directed movement of nucleotide sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "nucleotide-sulphate transport" EXACT [] is_a: GO:0008272 ! sulfate transport [Term] id: GO:0015716 name: phosphonate transport namespace: biological_process def: "The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:krc] subset: gosubset_prok is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015717 name: triose phosphate transport namespace: biological_process def: "The directed movement of triose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015749 ! monosaccharide transport [Term] id: GO:0015718 name: monocarboxylic acid transport namespace: biological_process def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0015719 name: allantoate transport namespace: biological_process def: "The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "allantoin/allantoate transport" BROAD [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042886 ! amide transport [Term] id: GO:0015720 name: allantoin transport namespace: biological_process def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "allantoin transmembrane transport" EXACT [GOC:mah] synonym: "allantoin/allantoate transport" BROAD [] is_a: GO:0042886 ! amide transport [Term] id: GO:0015721 name: bile acid and bile salt transport namespace: biological_process def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] synonym: "bile acid transport" NARROW [] synonym: "bile salt transport" NARROW [] xref: Reactome:1253295 "Recycling of bile acids and salts" xref: Reactome:1280235 "Recycling of bile acids and salts" xref: Reactome:1299095 "Recycling of bile acids and salts" xref: Reactome:1326811 "Recycling of bile acids and salts" xref: Reactome:1352912 "Recycling of bile acids and salts" xref: Reactome:1373118 "Recycling of bile acids and salts" xref: Reactome:1393134 "Recycling of bile acids and salts" xref: Reactome:1417621 "Recycling of bile acids and salts" xref: Reactome:1450717 "Recycling of bile acids and salts" xref: Reactome:1471279 "Recycling of bile acids and salts" xref: Reactome:1539317 "Recycling of bile acids and salts" xref: Reactome:159418 "Recycling of bile acids and salts" is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015722 name: canalicular bile acid transport namespace: biological_process def: "Catalysis of the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph] is_a: GO:0015721 ! bile acid and bile salt transport [Term] id: GO:0015723 name: bilirubin transport namespace: biological_process def: "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0015724 name: formate transport namespace: biological_process def: "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015711 ! organic anion transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015725 name: gluconate transport namespace: biological_process def: "The directed movement of gluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042873 ! aldonate transport [Term] id: GO:0015726 name: L-idonate transport namespace: biological_process def: "The directed movement of L-idonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:krc] subset: gosubset_prok is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042873 ! aldonate transport [Term] id: GO:0015727 name: lactate transport namespace: biological_process def: "The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015711 ! organic anion transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015728 name: mevalonate transport namespace: biological_process def: "The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015729 name: oxaloacetate transport namespace: biological_process def: "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0015730 name: propanoate transport namespace: biological_process def: "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "propionate transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015731 name: 3-hydroxyphenyl propanoate transport namespace: biological_process def: "The directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "3-hydroxyphenyl propionate transport" EXACT [] is_a: GO:0015730 ! propanoate transport [Term] id: GO:0015732 name: prostaglandin transport namespace: biological_process def: "The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0071715 ! icosanoid transport [Term] id: GO:0015733 name: shikimate transport namespace: biological_process def: "The directed movement of shikimate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015711 ! organic anion transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015734 name: taurine transport namespace: biological_process def: "The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015837 ! amine transport [Term] id: GO:0015735 name: uronic acid transport namespace: biological_process def: "The directed movement of uronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015749 ! monosaccharide transport [Term] id: GO:0015736 name: hexuronate transport namespace: biological_process def: "The directed movement of hexuronate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015711 ! organic anion transport is_a: GO:0015735 ! uronic acid transport [Term] id: GO:0015737 name: galacturonate transport namespace: biological_process def: "The directed movement of galacturonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015736 ! hexuronate transport [Term] id: GO:0015738 name: glucuronate transport namespace: biological_process def: "The directed movement of glucuronate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015736 ! hexuronate transport [Term] id: GO:0015739 name: sialic acid transport namespace: biological_process def: "The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015749 ! monosaccharide transport [Term] id: GO:0015740 name: C4-dicarboxylate transport namespace: biological_process def: "The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms." [GOC:krc, GOC:mah] subset: gosubset_prok is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0015741 name: fumarate transport namespace: biological_process def: "The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015742 name: alpha-ketoglutarate transport namespace: biological_process def: "The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok synonym: "2-oxoglutarate transport" EXACT [] synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015743 name: malate transport namespace: biological_process def: "The directed movement of malate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED [] is_a: GO:0015740 ! C4-dicarboxylate transport [Term] id: GO:0015744 name: succinate transport namespace: biological_process def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015711 ! organic anion transport is_a: GO:0015740 ! C4-dicarboxylate transport [Term] id: GO:0015745 name: tartrate transport namespace: biological_process def: "The directed movement of tartrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0042869 ! aldarate transport [Term] id: GO:0015746 name: citrate transport namespace: biological_process def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0006842 ! tricarboxylic acid transport is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015747 name: urate transport namespace: biological_process def: "The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "urate transmembrane transport" EXACT [GOC:mah] synonym: "uric acid transport" EXACT [] is_a: GO:0006863 ! purine base transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport [Term] id: GO:0015748 name: organophosphate ester transport namespace: biological_process def: "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015749 name: monosaccharide transport namespace: biological_process def: "The directed movement of monosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:ai] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0015750 name: pentose transport namespace: biological_process def: "The directed movement of pentoses into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A pentose is any aldose with a chain of five carbon atoms in the molecule." [GOC:ai] subset: gosubset_prok is_a: GO:0015749 ! monosaccharide transport [Term] id: GO:0015751 name: arabinose transport namespace: biological_process def: "The directed movement of arabinose, a pentose monosaccharide that occurs in both D and L configurations, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:22599, GOC:jl] subset: gosubset_prok is_a: GO:0015750 ! pentose transport [Term] id: GO:0015752 name: D-ribose transport namespace: biological_process def: "The directed movement of D-ribose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:ai] subset: gosubset_prok is_a: GO:0015750 ! pentose transport [Term] id: GO:0015753 name: D-xylose transport namespace: biological_process def: "The directed movement of D-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:ai] subset: gosubset_prok is_a: GO:0015750 ! pentose transport [Term] id: GO:0015754 name: allose transport namespace: biological_process def: "The directed movement of allose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015755 name: fructose transport namespace: biological_process def: "The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015756 name: fucose transport namespace: biological_process def: "The directed movement of fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015757 name: galactose transport namespace: biological_process def: "The directed movement of galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015758 name: glucose transport namespace: biological_process def: "The directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok xref: Reactome:1252923 "Glucose transport" xref: Reactome:1279857 "Glucose transport" xref: Reactome:1298771 "Glucose transport" xref: Reactome:1326426 "Glucose transport" xref: Reactome:1352542 "Glucose transport" xref: Reactome:1372769 "Glucose transport" xref: Reactome:1392779 "Glucose transport" xref: Reactome:1417256 "Glucose transport" xref: Reactome:1450345 "Glucose transport" xref: Reactome:1470886 "Glucose transport" xref: Reactome:1482918 "Glucose transport" xref: Reactome:1496714 "Glucose transport" xref: Reactome:1514105 "Glucose transport" xref: Reactome:1526675 "Glucose transport" xref: Reactome:1532402 "Glucose transport" xref: Reactome:1535961 "Glucose transport" xref: Reactome:70153 "Glucose transport" is_a: GO:0008645 ! hexose transport [Term] id: GO:0015759 name: beta-glucoside transport namespace: biological_process def: "The directed movement of beta-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0042946 ! glucoside transport [Term] id: GO:0015760 name: glucose-6-phosphate transport namespace: biological_process def: "The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] is_a: GO:0015712 ! hexose phosphate transport is_a: GO:0015758 ! glucose transport [Term] id: GO:0015761 name: mannose transport namespace: biological_process def: "The directed movement of mannose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015762 name: rhamnose transport namespace: biological_process def: "The directed movement of rhamnose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015763 name: N-acetylgalactosamine transport namespace: biological_process def: "The directed movement of N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015764 name: N-acetylglucosamine transport namespace: biological_process def: "The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015765 name: methylgalactoside transport namespace: biological_process def: "The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [CHEBI:55507, GOC:curators] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0015766 name: disaccharide transport namespace: biological_process def: "The directed movement of disaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units." [GOC:ai] subset: gosubset_prok is_a: GO:0015772 ! oligosaccharide transport [Term] id: GO:0015767 name: lactose transport namespace: biological_process def: "The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:ai] subset: gosubset_prok is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015768 name: maltose transport namespace: biological_process def: "The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch." [GOC:ai] subset: gosubset_prok is_a: GO:0000017 ! alpha-glucoside transport is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015769 name: melibiose transport namespace: biological_process def: "The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:ai] subset: gosubset_prok is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015770 name: sucrose transport namespace: biological_process def: "The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside." [GOC:ai] subset: gosubset_prok is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015771 name: trehalose transport namespace: biological_process def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai] subset: gosubset_prok is_a: GO:0000017 ! alpha-glucoside transport is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015772 name: oligosaccharide transport namespace: biological_process def: "The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:ai] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0015773 name: raffinose transport namespace: biological_process def: "The directed movement of raffinose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015772 ! oligosaccharide transport [Term] id: GO:0015774 name: polysaccharide transport namespace: biological_process def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages." [GOC:ai] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport relationship: part_of GO:0033037 ! polysaccharide localization [Term] id: GO:0015775 name: beta-glucan transport namespace: biological_process def: "The directed movement of beta-glucans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0015776 name: capsular polysaccharide transport namespace: biological_process def: "The directed movement of capsular polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai] subset: gosubset_prok synonym: "capsular-polysaccharide transport" EXACT [] synonym: "capsule polysaccharide transport" EXACT [] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0015777 name: teichoic acid transport namespace: biological_process def: "The directed movement of teichoic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai] subset: gosubset_prok is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0015778 name: hexuronide transport namespace: biological_process def: "The directed movement of hexuronide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0015779 name: glucuronoside transport namespace: biological_process def: "The directed movement of glucuronosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai] subset: gosubset_prok synonym: "glucuronide transport" EXACT [] is_a: GO:0015778 ! hexuronide transport [Term] id: GO:0015780 name: nucleotide-sugar transport namespace: biological_process def: "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0015781 name: pyrimidine nucleotide-sugar transport namespace: biological_process def: "The directed movement of pyrimidine nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai] is_a: GO:0015780 ! nucleotide-sugar transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport [Term] id: GO:0015782 name: CMP-N-acetylneuraminate transport namespace: biological_process def: "The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "CMP-sialic acid transport" BROAD [] is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport [Term] id: GO:0015783 name: GDP-fucose transport namespace: biological_process def: "The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] is_a: GO:0072530 ! purine-containing compound transmembrane transport [Term] id: GO:0015784 name: GDP-mannose transport namespace: biological_process def: "The directed movement of GDP-mannose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] is_a: GO:0072530 ! purine-containing compound transmembrane transport [Term] id: GO:0015785 name: UDP-galactose transport namespace: biological_process def: "The directed movement of UDP-galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai] is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport [Term] id: GO:0015786 name: UDP-glucose transport namespace: biological_process def: "The directed movement of UDP-glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport [Term] id: GO:0015787 name: UDP-glucuronic acid transport namespace: biological_process def: "The directed movement of UDP-glucuronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport [Term] id: GO:0015788 name: UDP-N-acetylglucosamine transport namespace: biological_process def: "The directed movement of UDP-N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport [Term] id: GO:0015789 name: UDP-N-acetylgalactosamine transport namespace: biological_process def: "The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport [Term] id: GO:0015790 name: UDP-xylose transport namespace: biological_process def: "The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport [Term] id: GO:0015791 name: polyol transport namespace: biological_process def: "The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0015850 ! organic alcohol transport [Term] id: GO:0015792 name: arabinitol transport namespace: biological_process def: "The directed movement of arabitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "arabitol transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015793 name: glycerol transport namespace: biological_process def: "The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] subset: gosubset_prok xref: Reactome:432030 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins" is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015794 name: glycerol-3-phosphate transport namespace: biological_process def: "The directed movement of glycerol-3-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015795 name: sorbitol transport namespace: biological_process def: "The directed movement of sorbitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucitol transport" EXACT [] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015796 name: galactitol transport namespace: biological_process def: "The directed movement of galactitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015797 name: mannitol transport namespace: biological_process def: "The directed movement of mannitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015798 name: myo-inositol transport namespace: biological_process def: "The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] subset: gosubset_prok synonym: "vitamin Bh transport" EXACT [] is_a: GO:0015791 ! polyol transport [Term] id: GO:0015799 name: propanediol transport namespace: biological_process def: "The directed movement of propanediol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [http://www.rhymezone.com] is_a: GO:0015791 ! polyol transport [Term] id: GO:0015800 name: acidic amino acid transport namespace: biological_process def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015801 name: aromatic amino acid transport namespace: biological_process def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015802 name: basic amino acid transport namespace: biological_process def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015803 name: branched-chain aliphatic amino acid transport namespace: biological_process def: "The directed movement of branched-chain aliphatic amino acids, amino acids with branched carbon skeleton without rings, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015804 name: neutral amino acid transport namespace: biological_process def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015805 name: S-adenosylmethionine transport namespace: biological_process def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "S-adenosyl methionine transport" EXACT [] is_a: GO:0015860 ! purine nucleoside transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015806 name: S-methylmethionine transport namespace: biological_process def: "The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0072337 ! modified amino acid transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015807 name: L-amino acid transport namespace: biological_process def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015808 name: L-alanine transport namespace: biological_process def: "The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok is_a: GO:0015807 ! L-amino acid transport is_a: GO:0032328 ! alanine transport [Term] id: GO:0015809 name: arginine transport namespace: biological_process def: "The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-arginine transport" NARROW [] is_a: GO:0015802 ! basic amino acid transport [Term] id: GO:0015810 name: aspartate transport namespace: biological_process def: "The directed movement of aspartate, the anion of aspartic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015800 ! acidic amino acid transport [Term] id: GO:0015811 name: L-cystine transport namespace: biological_process def: "The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0000101 ! sulfur amino acid transport is_a: GO:0015807 ! L-amino acid transport [Term] id: GO:0015812 name: gamma-aminobutyric acid transport namespace: biological_process def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'. subset: gosubset_prok synonym: "4-aminobutanoate transport" EXACT [] synonym: "4-aminobutyrate transport" EXACT [] synonym: "GABA transport" EXACT [] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015813 name: L-glutamate transport namespace: biological_process def: "The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015800 ! acidic amino acid transport [Term] id: GO:0015814 name: p-aminobenzoyl-glutamate transport namespace: biological_process def: "The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015816 name: glycine transport namespace: biological_process def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015817 name: histidine transport namespace: biological_process def: "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-histidine transport" NARROW [] is_a: GO:0015802 ! basic amino acid transport [Term] id: GO:0015818 name: isoleucine transport namespace: biological_process def: "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-isoleucine transport" NARROW [] is_a: GO:0015803 ! branched-chain aliphatic amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015819 name: lysine transport namespace: biological_process def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-lysine transport" NARROW [] is_a: GO:0015802 ! basic amino acid transport [Term] id: GO:0015820 name: leucine transport namespace: biological_process def: "The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-leucine transport" NARROW [] is_a: GO:0015803 ! branched-chain aliphatic amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015821 name: methionine transport namespace: biological_process def: "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-methionine transport" NARROW [] is_a: GO:0000101 ! sulfur amino acid transport [Term] id: GO:0015822 name: ornithine transport namespace: biological_process def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-ornithine transport" NARROW [] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015823 name: phenylalanine transport namespace: biological_process def: "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-phenylalanine transport" NARROW [] is_a: GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015824 name: proline transport namespace: biological_process def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-proline transport" NARROW [] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015825 name: L-serine transport namespace: biological_process def: "The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok is_a: GO:0015807 ! L-amino acid transport is_a: GO:0032329 ! serine transport [Term] id: GO:0015826 name: threonine transport namespace: biological_process def: "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-threonine transport" NARROW [] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015827 name: tryptophan transport namespace: biological_process def: "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-tryptophan transport" NARROW [] is_a: GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015828 name: tyrosine transport namespace: biological_process def: "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-tyrosine transport" NARROW [] is_a: GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015829 name: valine transport namespace: biological_process def: "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-valine transport" NARROW [] is_a: GO:0015803 ! branched-chain aliphatic amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015830 name: diaminopimelate transport namespace: biological_process def: "The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015711 ! organic anion transport is_a: GO:0015807 ! L-amino acid transport [Term] id: GO:0015832 name: holin namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0008565 consider: GO:0019835 [Term] id: GO:0015833 name: peptide transport namespace: biological_process def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0015834 name: peptidoglycan-associated peptide transport namespace: biological_process def: "The directed movement of peptidoglycan peptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "murein peptide transport" EXACT [] synonym: "muropeptide transport" EXACT [] synonym: "peptidoglycan peptide transport" EXACT [GOC:mah] is_a: GO:0015833 ! peptide transport [Term] id: GO:0015835 name: peptidoglycan transport namespace: biological_process def: "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "murein transport" EXACT [] is_a: GO:0006810 ! transport [Term] id: GO:0015836 name: lipid-linked peptidoglycan transport namespace: biological_process def: "The directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "lipid-linked murein transport" EXACT [] is_a: GO:0015835 ! peptidoglycan transport [Term] id: GO:0015837 name: amine transport namespace: biological_process def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "amine/polyamine transport" RELATED [] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015838 name: betaine transport namespace: biological_process def: "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0015697 ! quaternary ammonium group transport [Term] id: GO:0015839 name: cadaverine transport namespace: biological_process def: "The directed movement of cadaverine, 1,5-pentanediamine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0015837 ! amine transport [Term] id: GO:0015840 name: urea transport namespace: biological_process def: "The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0042886 ! amide transport [Term] id: GO:0015841 name: chromaffin granule amine transport namespace: biological_process def: "The directed movement of amines into, out of or within chromaffin granules." [GOC:mah] is_a: GO:0015837 ! amine transport [Term] id: GO:0015842 name: synaptic vesicle amine transport namespace: biological_process def: "The directed movement of amines into, out of or within synaptic vesicles." [GOC:ai] is_a: GO:0015837 ! amine transport is_a: GO:0048489 ! synaptic vesicle transport [Term] id: GO:0015843 name: methylammonium transport namespace: biological_process def: "The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015837 ! amine transport [Term] id: GO:0015844 name: monoamine transport namespace: biological_process alt_id: GO:0015873 def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:25375, GOC:mah] subset: gosubset_prok is_a: GO:0015837 ! amine transport [Term] id: GO:0015846 name: polyamine transport namespace: biological_process def: "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015837 ! amine transport [Term] id: GO:0015847 name: putrescine transport namespace: biological_process def: "The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015846 ! polyamine transport [Term] id: GO:0015848 name: spermidine transport namespace: biological_process def: "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015846 ! polyamine transport [Term] id: GO:0015849 name: organic acid transport namespace: biological_process def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015850 name: organic alcohol transport namespace: biological_process def: "The directed movement of organic alcohols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic alcohol is any carbon-containing compound containing a hydroxyl group." [GOC:ai] subset: gosubset_prok is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015851 name: nucleobase transport namespace: biological_process def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleobase transmembrane transport" EXACT [GOC:mah] is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0015853 name: adenine transport namespace: biological_process def: "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "adenine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine base transport [Term] id: GO:0015854 name: guanine transport namespace: biological_process def: "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] synonym: "guanine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine base transport [Term] id: GO:0015855 name: pyrimidine base transport namespace: biological_process def: "The directed movement of pyrimidine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:26432, GOC:ai] subset: gosubset_prok synonym: "pyrimidine base transmembrane transport" EXACT [GOC:mah] synonym: "pyrimidine nucleobase transport" EXACT [CHEBI:26432] synonym: "pyrimidine transmembrane transport" RELATED [GOC:mah] synonym: "pyrimidine transport" RELATED [GOC:curators] is_a: GO:0015851 ! nucleobase transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport [Term] id: GO:0015856 name: cytosine transport namespace: biological_process def: "The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] subset: gosubset_prok synonym: "cytosine transmembrane transport" EXACT [GOC:mah] is_a: GO:0015855 ! pyrimidine base transport [Term] id: GO:0015857 name: uracil transport namespace: biological_process def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] subset: gosubset_prok synonym: "uracil transmembrane transport" EXACT [GOC:mah] is_a: GO:0015855 ! pyrimidine base transport [Term] id: GO:0015858 name: nucleoside transport namespace: biological_process def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport [Term] id: GO:0015859 name: intracellular nucleoside transport namespace: biological_process def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell." [GOC:ai] is_a: GO:0015858 ! nucleoside transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0015860 name: purine nucleoside transport namespace: biological_process def: "The directed movement of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0015858 ! nucleoside transport is_a: GO:0072530 ! purine-containing compound transmembrane transport [Term] id: GO:0015861 name: cytidine transport namespace: biological_process def: "The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015864 ! pyrimidine nucleoside transport [Term] id: GO:0015862 name: uridine transport namespace: biological_process def: "The directed movement of uridine, uracil riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015864 ! pyrimidine nucleoside transport [Term] id: GO:0015863 name: xanthosine transport namespace: biological_process def: "The directed movement of xanthosine, xanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015860 ! purine nucleoside transport [Term] id: GO:0015864 name: pyrimidine nucleoside transport namespace: biological_process def: "The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015858 ! nucleoside transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport [Term] id: GO:0015865 name: purine nucleotide transport namespace: biological_process def: "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0006862 ! nucleotide transport is_a: GO:0072530 ! purine-containing compound transmembrane transport [Term] id: GO:0015866 name: ADP transport namespace: biological_process def: "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport [Term] id: GO:0015867 name: ATP transport namespace: biological_process def: "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport [Term] id: GO:0015868 name: purine ribonucleotide transport namespace: biological_process def: "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0015865 ! purine nucleotide transport [Term] id: GO:0015869 name: protein-DNA complex transport namespace: biological_process def: "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "DNA-protein complex transport" EXACT [GOC:mah] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport [Term] id: GO:0015870 name: acetylcholine transport namespace: biological_process def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015837 ! amine transport [Term] id: GO:0015871 name: choline transport namespace: biological_process def: "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] is_a: GO:0015697 ! quaternary ammonium group transport is_a: GO:0015850 ! organic alcohol transport [Term] id: GO:0015872 name: dopamine transport namespace: biological_process def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0015874 name: norepinephrine transport namespace: biological_process def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "levarterenol transport" EXACT [] synonym: "noradrenaline transport" EXACT [] is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0015875 name: vitamin or cofactor transport namespace: biological_process def: "OBSOLETE. The directed movement of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. is_obsolete: true consider: GO:0051180 consider: GO:0051181 [Term] id: GO:0015876 name: acetyl-CoA transport namespace: biological_process def: "The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0015877 name: biopterin transport namespace: biological_process def: "The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai] is_a: GO:0051181 ! cofactor transport [Term] id: GO:0015878 name: biotin transport namespace: biological_process def: "The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] synonym: "vitamin B7 transport" EXACT [] synonym: "vitamin H transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042886 ! amide transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051181 ! cofactor transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0015879 name: carnitine transport namespace: biological_process def: "The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] subset: gosubset_prok synonym: "vitamin Bt transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0015838 ! betaine transport [Term] id: GO:0015880 name: coenzyme A transport namespace: biological_process def: "The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0015881 name: creatine transport namespace: biological_process def: "The directed movement of creatine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015882 name: L-ascorbic acid transport namespace: biological_process def: "The directed movement of L-ascorbic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:ai] synonym: "L-ascorbate transport" EXACT [] synonym: "vitamin C transport" EXACT [] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0051180 ! vitamin transport [Term] id: GO:0015883 name: FAD transport namespace: biological_process def: "The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "flavin adenine dinucleotide transport" EXACT [] synonym: "flavin-adenine dinucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0015884 name: folic acid transport namespace: biological_process def: "The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transport" EXACT [] synonym: "vitamin B9 transport" EXACT [] synonym: "vitamin M transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0015885 name: 5-formyltetrahydrofolate transport namespace: biological_process def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051181 ! cofactor transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015886 name: heme transport namespace: biological_process def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "haem transport" EXACT [] is_a: GO:0051181 ! cofactor transport [Term] id: GO:0015887 name: pantothenate transmembrane transport namespace: biological_process def: "The directed movement of pantothenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "pantothenate transport" EXACT [GOC:mah] synonym: "vitamin B5 transport" EXACT [] is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015888 name: thiamine transport namespace: biological_process def: "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai] subset: gosubset_prok synonym: "thiamin transport" EXACT [GOC:curators] synonym: "vitamin B1 transport" EXACT [] is_a: GO:0051180 ! vitamin transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015889 name: cobalamin transport namespace: biological_process def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "vitamin B12 transport" EXACT [] is_a: GO:0051180 ! vitamin transport [Term] id: GO:0015890 name: nicotinamide mononucleotide transport namespace: biological_process def: "The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [CHEBI:50383, GOC:curators, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "nicotinamide ribonucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0015891 name: siderophore transport namespace: biological_process alt_id: GO:0015892 def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "iron-siderochrome transport" NARROW [] synonym: "iron-siderophore transport" EXACT [] synonym: "siderochrome transport" NARROW [] synonym: "siderophore-iron transport" EXACT [] is_a: GO:0015688 ! iron chelate transport relationship: part_of GO:0033214 ! iron assimilation by chelation and transport [Term] id: GO:0015893 name: drug transport namespace: biological_process def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport relationship: part_of GO:0042493 ! response to drug [Term] id: GO:0015894 name: acriflavine transport namespace: biological_process def: "The directed movement of acriflavine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [GOC:curators, PubChem_Compound:6842] synonym: "acriflavin transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0015893 ! drug transport is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0015895 name: alkane transport namespace: biological_process def: "The directed movement of alkanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] is_a: GO:0006810 ! transport [Term] id: GO:0015896 name: nalidixic acid transport namespace: biological_process def: "The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221] is_a: GO:0042891 ! antibiotic transport is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0015897 name: organomercurial transport namespace: biological_process def: "The directed movement of organomercurial compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai] is_a: GO:0015893 ! drug transport [Term] id: GO:0015898 name: amiloride transport namespace: biological_process def: "The directed movement amiloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [GOC:ai] is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport [Term] id: GO:0015899 name: aminotriazole transport namespace: biological_process def: "The directed movement of aminotriazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [CHEBI:40036, GOC:curators] is_a: GO:0015837 ! amine transport is_a: GO:0045117 ! azole transport [Term] id: GO:0015900 name: benomyl transport namespace: biological_process def: "The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [CHEBI:3015, GOC:curators] is_a: GO:0015893 ! drug transport is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0015901 name: cycloheximide transport namespace: biological_process def: "The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0015902 name: carbonyl cyanide m-chlorophenylhydrazone transport namespace: biological_process def: "The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [CHEBI:3259, GOC:curators] synonym: "CCCP transport" EXACT [] is_a: GO:0015893 ! drug transport [Term] id: GO:0015903 name: fluconazole transport namespace: biological_process def: "The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [CHEBI:46081, GOC:curators] is_a: GO:0015850 ! organic alcohol transport is_a: GO:0045117 ! azole transport [Term] id: GO:0015904 name: tetracycline transport namespace: biological_process def: "The directed movement of tetracycline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:curators] subset: gosubset_prok synonym: "tetracyclin transport" EXACT [] is_a: GO:0015850 ! organic alcohol transport is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0015905 name: bicyclomycin transport namespace: biological_process def: "The directed movement of bicyclomycin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X] subset: gosubset_prok is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0015906 name: sulfathiazole transport namespace: biological_process def: "The directed movement of sulfathiazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sulfathiazole is an antibacterial agent of the sulfonamide group." [CHEBI:9337, GOC:curators] synonym: "sulphathiazole transport" EXACT [] is_a: GO:0045117 ! azole transport [Term] id: GO:0015908 name: fatty acid transport namespace: biological_process def: "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai] subset: gosubset_prok is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015909 name: long-chain fatty acid transport namespace: biological_process def: "The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length greater than C12." [GOC:ai] subset: gosubset_prok xref: Reactome:804914 "Transport of fatty acids" is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0015910 name: peroxisomal long-chain fatty acid import namespace: biological_process def: "The directed movement of long-chain fatty acids into a peroxisome." [GOC:ai] synonym: "peroxisomal long-chain fatty acid uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015909 ! long-chain fatty acid transport [Term] id: GO:0015911 name: plasma membrane long-chain fatty acid transport namespace: biological_process def: "The directed movement of long-chain fatty acids across the plasma membrane." [GOC:ai] is_a: GO:0015909 ! long-chain fatty acid transport [Term] id: GO:0015912 name: short-chain fatty acid transport namespace: biological_process def: "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons." [GOC:ai] subset: gosubset_prok is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0015913 name: short-chain fatty acid import namespace: biological_process def: "The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons." [GOC:ai] synonym: "short-chain fatty acid uptake" EXACT [] is_a: GO:0015912 ! short-chain fatty acid transport [Term] id: GO:0015914 name: phospholipid transport namespace: biological_process def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai] subset: gosubset_prok is_a: GO:0006869 ! lipid transport [Term] id: GO:0015915 name: fatty-acyl group transport namespace: biological_process def: "The directed movement of fatty acyl groups into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid." [GOC:ai] synonym: "fatty acyl transport" EXACT [GOC:curators] is_a: GO:0006869 ! lipid transport [Term] id: GO:0015916 name: fatty-acyl-CoA transport namespace: biological_process def: "The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "fatty acyl CoA transport" EXACT [GOC:curators] synonym: "fatty acyl coenzyme A transport" EXACT [] synonym: "fatty acyl-CoA transport" EXACT [] is_a: GO:0015915 ! fatty-acyl group transport [Term] id: GO:0015917 name: aminophospholipid transport namespace: biological_process def: "The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai] is_a: GO:0006869 ! lipid transport [Term] id: GO:0015918 name: sterol transport namespace: biological_process def: "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] xref: Reactome:1253597 "Trafficking of dietary sterols" xref: Reactome:1280528 "Trafficking of dietary sterols" xref: Reactome:1299359 "Trafficking of dietary sterols" xref: Reactome:1327114 "Trafficking of dietary sterols" xref: Reactome:1353209 "Trafficking of dietary sterols" xref: Reactome:1373385 "Trafficking of dietary sterols" xref: Reactome:1393410 "Trafficking of dietary sterols" xref: Reactome:1417905 "Trafficking of dietary sterols" xref: Reactome:1450995 "Trafficking of dietary sterols" xref: Reactome:1471378 "Trafficking of dietary sterols" xref: Reactome:1483334 "Trafficking of dietary sterols" xref: Reactome:1497016 "Trafficking of dietary sterols" xref: Reactome:1514403 "Trafficking of dietary sterols" xref: Reactome:1521272 "Trafficking of dietary sterols" xref: Reactome:1526977 "Trafficking of dietary sterols" xref: Reactome:265473 "Trafficking of dietary sterols" is_a: GO:0006869 ! lipid transport [Term] id: GO:0015919 name: peroxisomal membrane transport namespace: biological_process def: "The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai] is_a: GO:0043574 ! peroxisomal transport [Term] id: GO:0015920 name: lipopolysaccharide transport namespace: biological_process def: "The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "LPS transport" EXACT [] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0015921 name: lipopolysaccharide export namespace: biological_process def: "The directed movement of lipopolysaccharides out of a cell or organelle." [GOC:ai] subset: gosubset_prok synonym: "LPS export" EXACT [] is_a: GO:0015920 ! lipopolysaccharide transport [Term] id: GO:0015922 name: aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.1, EC:1.4.3.16] subset: gosubset_prok xref: EC:1.4.3.- is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0015923 name: mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015924 name: mannosyl-oligosaccharide mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." [EC:3.2.1.-, GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0015925 name: galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015926 name: glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.2.1.- is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015927 name: trehalase activity namespace: molecular_function def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- xref: MetaCyc:TREHALA-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015928 name: fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015929 name: hexosaminidase activity namespace: molecular_function def: "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [http://www.onelook.com/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok xref: EC:3.2.1.- xref: MetaCyc:3.2.1.52-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015930 name: glutamate synthase activity namespace: molecular_function def: "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-] subset: gosubset_prok xref: EC:1.4.-.- is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0015931 name: nucleobase, nucleoside, nucleotide and nucleic acid transport namespace: biological_process def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0015932 name: nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0015933 name: flavin-containing electron transporter namespace: molecular_function def: "OBSOLETE. An oxidoreductase which contains either flavin-adenine dinucleotide or flavin mononucleotide as a prosthetic group, utilizes either NADH or NADPH and transfers electrons to other electron transfer proteins." [GOC:kd] comment: This term was made obsolete because it does not describe a molecular function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015934 name: large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribosomal large subunit" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005840 ! ribosome [Term] id: GO:0015935 name: small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a ribosome." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "ribosomal small subunit" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005840 ! ribosome [Term] id: GO:0015936 name: coenzyme A metabolic process namespace: biological_process alt_id: GO:0006763 def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] subset: gosubset_prok synonym: "CoA metabolism" EXACT [] synonym: "coenzyme A metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0033865 ! nucleoside bisphosphate metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0015937 name: coenzyme A biosynthetic process namespace: biological_process alt_id: GO:0006764 def: "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] subset: gosubset_prok synonym: "CoA biosynthesis" EXACT [] synonym: "coenzyme A anabolism" EXACT [] synonym: "coenzyme A biosynthesis" EXACT [] synonym: "coenzyme A formation" EXACT [] synonym: "coenzyme A synthesis" EXACT [] xref: MetaCyc:COA-PWY xref: MetaCyc:PANTOSYN-PWY xref: MetaCyc:PWY-4221 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0015936 ! coenzyme A metabolic process [Term] id: GO:0015938 name: coenzyme A catabolic process namespace: biological_process alt_id: GO:0006765 def: "The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] subset: gosubset_prok synonym: "CoA catabolism" EXACT [] synonym: "coenzyme A breakdown" EXACT [] synonym: "coenzyme A catabolism" EXACT [] synonym: "coenzyme A degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0015936 ! coenzyme A metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0015939 name: pantothenate metabolic process namespace: biological_process alt_id: GO:0006770 def: "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "pantothenate metabolism" EXACT [] synonym: "vitamin B5 metabolic process" EXACT [] synonym: "vitamin B5 metabolism" EXACT [] xref: Reactome:1253503 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1280442 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1299276 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1327020 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1353114 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1373303 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1393316 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1417814 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1450912 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1471292 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1483265 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1496941 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1514328 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1521193 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1526939 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1532678 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1536089 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1538060 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1539341 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:1540343 "Vitamin B5 (pantothenate) metabolism" xref: Reactome:199220 "Vitamin B5 (pantothenate) metabolism" is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process [Term] id: GO:0015940 name: pantothenate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "pantothenate anabolism" EXACT [] synonym: "pantothenate biosynthesis" EXACT [] synonym: "pantothenate formation" EXACT [] synonym: "pantothenate synthesis" EXACT [] synonym: "vitamin B5 biosynthesis" EXACT [] synonym: "vitamin B5 biosynthetic process" EXACT [] xref: MetaCyc:PANTOSYN-PWY xref: MetaCyc:PWY-4221 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0015939 ! pantothenate metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0015941 name: pantothenate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "pantothenate breakdown" EXACT [] synonym: "pantothenate catabolism" EXACT [] synonym: "pantothenate degradation" EXACT [] synonym: "vitamin B5 catabolic process" EXACT [] synonym: "vitamin B5 catabolism" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0015939 ! pantothenate metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process [Term] id: GO:0015942 name: formate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "formate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0015943 name: formate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "formate anabolism" EXACT [] synonym: "formate biosynthesis" EXACT [] synonym: "formate formation" EXACT [] synonym: "formate synthesis" EXACT [] synonym: "formic acid biosynthesis" EXACT [] synonym: "formic acid biosynthetic process" EXACT [] is_a: GO:0015942 ! formate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0015944 name: formate oxidation namespace: biological_process def: "The chemical reactions and pathways by which formate is converted to CO2." [MetaCyc:PWY-1881] subset: gosubset_prok synonym: "formic acid oxidation" EXACT [] xref: MetaCyc:PWY-1881 is_a: GO:0015942 ! formate metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015945 name: methanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methanol metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0015946 name: methanol oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M." [MetaCyc:CO2FORM-PWY] subset: gosubset_prok xref: MetaCyc:CO2FORM-PWY is_a: GO:0015945 ! methanol metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015947 name: methane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methane metabolism" EXACT [] is_a: GO:0043446 ! cellular alkane metabolic process [Term] id: GO:0015948 name: methanogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "methane biosynthesis" EXACT [] synonym: "methane biosynthetic process" EXACT [] xref: UM-BBD_pathwayID:meth xref: Wikipedia:Methanogenesis is_a: GO:0009061 ! anaerobic respiration is_a: GO:0015947 ! methane metabolic process is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0043447 ! alkane biosynthetic process [Term] id: GO:0015949 name: nucleobase, nucleoside and nucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide is synthesized from another nucleobase, nucleoside or nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: goslim_pir subset: gosubset_prok xref: MetaCyc:P1-PWY xref: Reactome:1252961 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1279891 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1298801 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1326464 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1352577 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1372805 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1392818 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1417291 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1450380 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1470935 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1482947 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1496732 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1514122 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1520949 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1526697 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1532423 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1535978 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1537991 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1539241 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:1540318 "Synthesis and interconversion of nucleotide di- and triphosphates" xref: Reactome:499943 "Synthesis and interconversion of nucleotide di- and triphosphates" is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process [Term] id: GO:0015950 name: purine nucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion [Term] id: GO:0015951 name: purine ribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0015950 ! purine nucleotide interconversion [Term] id: GO:0015952 name: purine deoxyribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0015950 ! purine nucleotide interconversion [Term] id: GO:0015953 name: pyrimidine nucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion [Term] id: GO:0015954 name: pyrimidine ribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0015953 ! pyrimidine nucleotide interconversion [Term] id: GO:0015955 name: pyrimidine deoxyribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0015953 ! pyrimidine nucleotide interconversion [Term] id: GO:0015956 name: bis(5'-nucleosidyl) oligophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] subset: gosubset_prok synonym: "bis(5'-nucleosidyl) oligophosphate metabolism" EXACT [] is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0015957 name: bis(5'-nucleosidyl) oligophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] subset: gosubset_prok synonym: "bis(5'-nucleosidyl) oligophosphate anabolism" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate biosynthesis" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate formation" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate synthesis" EXACT [] is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0015958 name: bis(5'-nucleosidyl) oligophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] subset: gosubset_prok synonym: "bis(5'-nucleosidyl) oligophosphate breakdown" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate catabolism" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate degradation" EXACT [] is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0015959 name: diadenosine polyphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] subset: gosubset_prok synonym: "diadenosine polyphosphate metabolism" EXACT [] is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process [Term] id: GO:0015960 name: diadenosine polyphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] subset: gosubset_prok synonym: "diadenosine polyphosphate anabolism" EXACT [] synonym: "diadenosine polyphosphate biosynthesis" EXACT [] synonym: "diadenosine polyphosphate formation" EXACT [] synonym: "diadenosine polyphosphate synthesis" EXACT [] is_a: GO:0015957 ! bis(5'-nucleosidyl) oligophosphate biosynthetic process is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015961 name: diadenosine polyphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] subset: gosubset_prok synonym: "diadenosine polyphosphate breakdown" EXACT [] synonym: "diadenosine polyphosphate catabolism" EXACT [] synonym: "diadenosine polyphosphate degradation" EXACT [] is_a: GO:0015958 ! bis(5'-nucleosidyl) oligophosphate catabolic process is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015962 name: diadenosine triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] subset: gosubset_prok synonym: "diadenosine triphosphate metabolism" EXACT [] is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015963 name: diadenosine triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] subset: gosubset_prok synonym: "diadenosine triphosphate anabolism" EXACT [] synonym: "diadenosine triphosphate biosynthesis" EXACT [] synonym: "diadenosine triphosphate formation" EXACT [] synonym: "diadenosine triphosphate synthesis" EXACT [] is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process is_a: GO:0015962 ! diadenosine triphosphate metabolic process [Term] id: GO:0015964 name: diadenosine triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] subset: gosubset_prok synonym: "diadenosine triphosphate breakdown" EXACT [] synonym: "diadenosine triphosphate catabolism" EXACT [] synonym: "diadenosine triphosphate degradation" EXACT [] is_a: GO:0015961 ! diadenosine polyphosphate catabolic process is_a: GO:0015962 ! diadenosine triphosphate metabolic process [Term] id: GO:0015965 name: diadenosine tetraphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] subset: gosubset_prok synonym: "diadenosine tetraphosphate metabolism" EXACT [] is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015966 name: diadenosine tetraphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] subset: gosubset_prok synonym: "diadenosine tetraphosphate anabolism" EXACT [] synonym: "diadenosine tetraphosphate biosynthesis" EXACT [] synonym: "diadenosine tetraphosphate formation" EXACT [] synonym: "diadenosine tetraphosphate synthesis" EXACT [] is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process [Term] id: GO:0015967 name: diadenosine tetraphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] subset: gosubset_prok synonym: "diadenosine tetraphosphate breakdown" EXACT [] synonym: "diadenosine tetraphosphate catabolism" EXACT [] synonym: "diadenosine tetraphosphate degradation" EXACT [] is_a: GO:0015961 ! diadenosine polyphosphate catabolic process is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process [Term] id: GO:0015968 name: stringent response namespace: biological_process def: "A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation." [GOC:jl, ISBN:0124325653, PMID:11282471] subset: gosubset_prok xref: Wikipedia:Stringent_response is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0015969 name: guanosine tetraphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] subset: gosubset_prok synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolic process" EXACT [] synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolism" EXACT [] synonym: "guanosine tetraphosphate metabolism" EXACT [] xref: MetaCyc:PPGPPMET-PWY is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0033865 ! nucleoside bisphosphate metabolic process [Term] id: GO:0015970 name: guanosine tetraphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] subset: gosubset_prok synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthesis" EXACT [] synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process" EXACT [] synonym: "guanosine tetraphosphate anabolism" EXACT [] synonym: "guanosine tetraphosphate biosynthesis" EXACT [] synonym: "guanosine tetraphosphate formation" EXACT [] synonym: "guanosine tetraphosphate synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0015969 ! guanosine tetraphosphate metabolic process is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process [Term] id: GO:0015971 name: guanosine tetraphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] subset: gosubset_prok synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolic process" EXACT [] synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolism" EXACT [] synonym: "guanosine tetraphosphate breakdown" EXACT [] synonym: "guanosine tetraphosphate catabolism" EXACT [] synonym: "guanosine tetraphosphate degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0015969 ! guanosine tetraphosphate metabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0015972 name: guanosine pentaphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] subset: gosubset_prok synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolic process" EXACT [] synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolism" EXACT [] synonym: "guanosine pentaphosphate metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process [Term] id: GO:0015973 name: guanosine pentaphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] subset: gosubset_prok synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthesis" EXACT [] synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process" EXACT [] synonym: "guanosine pentaphosphate anabolism" EXACT [] synonym: "guanosine pentaphosphate biosynthesis" EXACT [] synonym: "guanosine pentaphosphate formation" EXACT [] synonym: "guanosine pentaphosphate synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0015972 ! guanosine pentaphosphate metabolic process [Term] id: GO:0015974 name: guanosine pentaphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] subset: gosubset_prok synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolic process" EXACT [] synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolism" EXACT [] synonym: "guanosine pentaphosphate breakdown" EXACT [] synonym: "guanosine pentaphosphate catabolism" EXACT [] synonym: "guanosine pentaphosphate degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0015972 ! guanosine pentaphosphate metabolic process [Term] id: GO:0015975 name: energy derivation by oxidation of reduced inorganic compounds namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] subset: gosubset_prok synonym: "chemolithotrophie" EXACT [] synonym: "chemolithotrophy" EXACT [] synonym: "lithotrophy" EXACT [Wikipedia:Lithotrophy] xref: Wikipedia:Lithotrophy is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015976 name: carbon utilization namespace: biological_process alt_id: GO:0015978 def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: goslim_pir subset: gosubset_prok synonym: "carbon utilization by utilization of organic compounds" EXACT [GOC:mah] synonym: "heterotrophy" EXACT [] xref: Wikipedia:Heterotroph is_a: GO:0008150 ! biological_process [Term] id: GO:0015977 name: carbon fixation namespace: biological_process def: "A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates)." [GOC:jl, GOC:mah] subset: gosubset_prok synonym: "autotrophic CO2 fixation" EXACT [] synonym: "autotrophic CO2 fixation pathway" EXACT [] synonym: "autotrophy" EXACT [] xref: Wikipedia:Autotrophy is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0015979 name: photosynthesis namespace: biological_process def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Photosynthesis is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0015980 name: energy derivation by oxidation of organic compounds namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] subset: gosubset_prok synonym: "chemoorganotrophy" EXACT [] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015981 name: passive proton transport, down the electrochemical gradient namespace: biological_process def: "OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low." [ISBN:0716731363] comment: This term was made obsolete because it represents a passive process which occurs without the aid of gene products. is_obsolete: true consider: GO:0015992 [Term] id: GO:0015982 name: antiport namespace: biological_process def: "OBSOLETE. The process of coupled solute translocation in which two solutes equilibrate across an osmotic barrier, the translocation of solute being coupled to the translocation of the other in the opposite direction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true replaced_by: GO:0015297 [Term] id: GO:0015983 name: symport namespace: biological_process def: "OBSOLETE. The process of solute translocation in which two solutes equilibrate across an osmotic barrier, and the translocation of one solute is coupled to the translocation of the other in the same direction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true replaced_by: GO:0015293 [Term] id: GO:0015984 name: uniport namespace: biological_process def: "OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true replaced_by: GO:0015292 [Term] id: GO:0015985 name: energy coupled proton transport, down electrochemical gradient namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP." [GOC:mah] subset: gosubset_prok is_a: GO:0015992 ! proton transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0015986 name: ATP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] subset: gosubset_prok synonym: "chemiosmosis" BROAD [GOC:rs] is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient [Term] id: GO:0015987 name: GTP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis." [ISBN:0716731363] is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient [Term] id: GO:0015988 name: energy coupled proton transport, against electrochemical gradient namespace: biological_process def: "The transport of protons against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport." [GOC:mah] subset: gosubset_prok is_a: GO:0015992 ! proton transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0015989 name: light-driven proton transport namespace: biological_process def: "The transport of protons against an electrochemical gradient, using energy from light." [GOC:mah] is_a: GO:0015988 ! energy coupled proton transport, against electrochemical gradient [Term] id: GO:0015990 name: electron transport coupled proton transport namespace: biological_process def: "The transport of protons against an electrochemical gradient, using energy from electron transport." [GOC:mah] is_a: GO:0015988 ! energy coupled proton transport, against electrochemical gradient [Term] id: GO:0015991 name: ATP hydrolysis coupled proton transport namespace: biological_process def: "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah] subset: gosubset_prok is_a: GO:0015988 ! energy coupled proton transport, against electrochemical gradient [Term] id: GO:0015992 name: proton transport namespace: biological_process def: "The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] subset: gosubset_prok synonym: "hydrogen ion transport" EXACT [] synonym: "passive proton transport, down the electrochemical gradient" NARROW [] xref: Reactome:1253352 "Mitochondrial Uncoupling Proteins" xref: Reactome:1253371 "The proton buffering model" xref: Reactome:1280290 "Mitochondrial Uncoupling Proteins" xref: Reactome:1280311 "The proton buffering model" xref: Reactome:1299141 "Mitochondrial Uncoupling Proteins" xref: Reactome:1299164 "The proton buffering model" xref: Reactome:1326868 "Mitochondrial Uncoupling Proteins" xref: Reactome:1326889 "The proton buffering model" xref: Reactome:1352960 "Mitochondrial Uncoupling Proteins" xref: Reactome:1352981 "The proton buffering model" xref: Reactome:1373162 "Mitochondrial Uncoupling Proteins" xref: Reactome:1373179 "The proton buffering model" xref: Reactome:1393179 "Mitochondrial Uncoupling Proteins" xref: Reactome:1393190 "The proton buffering model" xref: Reactome:1417666 "Mitochondrial Uncoupling Proteins" xref: Reactome:1417684 "The proton buffering model" xref: Reactome:1450766 "Mitochondrial Uncoupling Proteins" xref: Reactome:1450787 "The proton buffering model" xref: Reactome:1496891 "Mitochondrial Uncoupling Proteins" xref: Reactome:1496895 "The proton buffering model" xref: Reactome:1514284 "Mitochondrial Uncoupling Proteins" xref: Reactome:1514288 "The proton buffering model" xref: Reactome:166187 "Mitochondrial Uncoupling Proteins" xref: Reactome:167827 "The proton buffering model" is_a: GO:0006818 ! hydrogen transport is_a: GO:0015672 ! monovalent inorganic cation transport [Term] id: GO:0015993 name: molecular hydrogen transport namespace: biological_process def: "The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0006818 ! hydrogen transport [Term] id: GO:0015994 name: chlorophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] subset: gosubset_prok synonym: "chlorophyll metabolism" EXACT [] is_a: GO:0006778 ! porphyrin metabolic process [Term] id: GO:0015995 name: chlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl] subset: gosubset_prok synonym: "chlorophyll anabolism" EXACT [] synonym: "chlorophyll biosynthesis" EXACT [] synonym: "chlorophyll formation" EXACT [] synonym: "chlorophyll synthesis" EXACT [] xref: MetaCyc:CHLOROPHYLL-SYN is_a: GO:0006779 ! porphyrin biosynthetic process is_a: GO:0015994 ! chlorophyll metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0015996 name: chlorophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products." [GOC:jl] subset: gosubset_prok synonym: "chlorophyll breakdown" EXACT [] synonym: "chlorophyll catabolism" EXACT [] synonym: "chlorophyll degradation" EXACT [] is_a: GO:0006787 ! porphyrin catabolic process is_a: GO:0015994 ! chlorophyll metabolic process is_a: GO:0046149 ! pigment catabolic process [Term] id: GO:0015997 name: ubiquinone biosynthetic process monooxygenase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it incorporates biological process information. synonym: "coenzyme Q biosynthesis monooxygenase activity" EXACT [] synonym: "coenzyme Q biosynthetic process monooxygenase activity" EXACT [] synonym: "ubiquinone anabolism monooxygenase activity" EXACT [] synonym: "ubiquinone formation monooxygenase activity" EXACT [] synonym: "ubiquinone synthesis monooxygenase activity" EXACT [] is_obsolete: true [Term] id: GO:0016002 name: sulfite reductase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [EC:1.8.99.1] subset: gosubset_prok synonym: "assimilatory sulfite reductase activity" EXACT [EC:1.8.99.1] synonym: "assimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.1] synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.1] synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [EC:1.8.99.1] synonym: "siroheme sulfite reductase activity" NARROW [MetaCyc:SULFITE-REDUCTASE-RXN] synonym: "sulphite reductase activity" EXACT [] xref: EC:1.8.99.1 xref: MetaCyc:SULFITE-REDUCTASE-RXN is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016004 name: phospholipase activator activity namespace: molecular_function def: "Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai] is_a: GO:0060229 ! lipase activator activity [Term] id: GO:0016005 name: phospholipase A2 activator activity namespace: molecular_function def: "Increases the activity of the enzyme phospholipase A2." [GOC:ai] is_a: GO:0016004 ! phospholipase activator activity [Term] id: GO:0016006 name: Nebenkern namespace: cellular_component def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] is_a: GO:0005739 ! mitochondrion [Term] id: GO:0016007 name: mitochondrial derivative namespace: cellular_component def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma] is_a: GO:0005739 ! mitochondrion [Term] id: GO:0016008 name: major mitochondrial derivative namespace: cellular_component def: "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative." [GOC:mah, PMID:17123504] is_a: GO:0016007 ! mitochondrial derivative [Term] id: GO:0016009 name: minor mitochondrial derivative namespace: cellular_component def: "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation." [GOC:mah, PMID:17123504] is_a: GO:0016007 ! mitochondrial derivative [Term] id: GO:0016010 name: dystrophin-associated glycoprotein complex namespace: cellular_component def: "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609] subset: goslim_pir synonym: "DGC" EXACT [] synonym: "dystrophin glycoprotein complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0016011 name: dystroglycan complex namespace: cellular_component def: "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex [Term] id: GO:0016012 name: sarcoglycan complex namespace: cellular_component def: "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609] synonym: "sarcoglycan-sarcospan complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0016011 ! dystroglycan complex [Term] id: GO:0016013 name: syntrophin complex namespace: cellular_component def: "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn] synonym: "nitric oxide synthase-dystrophin complex, skeletal muscle" RELATED [CORUM:416] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex [Term] id: GO:0016014 name: dystrobrevin complex namespace: cellular_component def: "A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex." [PMID:15117830, PMID:16710609] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex [Term] id: GO:0016015 name: morphogen activity namespace: molecular_function def: "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators] is_a: GO:0003674 ! molecular_function [Term] id: GO:0016016 name: short-wave-sensitive opsin namespace: molecular_function def: "OBSOLETE. An opsin with maximal absorption between 400 and 500 nm." [PMID:10594055] comment: This term was made obsolete because it refers to a class of proteins. is_obsolete: true consider: GO:0007603 consider: GO:0009588 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0016018 name: cyclosporin A binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb] synonym: "cyclophilin" RELATED [] is_a: GO:0008144 ! drug binding is_a: GO:0042277 ! peptide binding [Term] id: GO:0016019 name: peptidoglycan receptor activity namespace: molecular_function def: "Combining with a peptidoglycan to initiate a change in cell activity." [PMID:14698226] comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead. synonym: "peptidoglycan recognition activity" NARROW [] is_a: GO:0008329 ! pattern recognition receptor activity is_a: GO:0042834 ! peptidoglycan binding [Term] id: GO:0016020 name: membrane namespace: cellular_component def: "Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Biological_membrane is_a: GO:0044464 ! cell part [Term] id: GO:0016021 name: integral to membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators] subset: gosubset_prok synonym: "transmembrane" RELATED [GOC:mah] xref: Wikipedia:Transmembrane_protein is_a: GO:0031224 ! intrinsic to membrane [Term] id: GO:0016023 name: cytoplasmic membrane-bounded vesicle namespace: cellular_component def: "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "cytoplasmic membrane bounded vesicle" EXACT [] synonym: "cytoplasmic membrane-enclosed vesicle" EXACT [] is_a: GO:0031410 ! cytoplasmic vesicle is_a: GO:0031988 ! membrane-bounded vesicle is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0016024 name: CDP-diacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [CHEBI:17962, GOC:curators] subset: gosubset_prok synonym: "CDP-diacylglycerol anabolism" EXACT [] synonym: "CDP-diacylglycerol biosynthesis" EXACT [] synonym: "CDP-diacylglycerol formation" EXACT [] synonym: "CDP-diacylglycerol synthesis" EXACT [] is_a: GO:0006651 ! diacylglycerol biosynthetic process is_a: GO:0046341 ! CDP-diacylglycerol metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0016025 name: proteasome endopeptidase regulator namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0004175 [Term] id: GO:0016026 name: proteasome endopeptidase core namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0004175 [Term] id: GO:0016027 name: inaD signaling complex namespace: cellular_component def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] synonym: "inaD signalling complex" EXACT [] is_a: GO:0019897 ! extrinsic to plasma membrane is_a: GO:0043234 ! protein complex is_a: GO:0044463 ! cell projection part relationship: part_of GO:0016028 ! rhabdomere [Term] id: GO:0016028 name: rhabdomere namespace: cellular_component def: "The specialized microvillar organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, PMID:8646774] subset: goslim_pir is_a: GO:0042995 ! cell projection [Term] id: GO:0016029 name: subrhabdomeral cisterna namespace: cellular_component def: "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774] synonym: "SMC" RELATED [] synonym: "submicrovillar cisterna" EXACT [PMID:11707492] is_a: GO:0031984 ! organelle subcompartment is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0005790 ! smooth endoplasmic reticulum relationship: part_of GO:0016028 ! rhabdomere [Term] id: GO:0016030 name: metarhodopsin binding namespace: molecular_function def: "Interacting selectively and non-covalently with metarhodopsin, a transient intermediate produced upon irradiation of rhodopsin in the visual cycle and existing in two forms, metarhodopsins I and II. The latter dissociates to form opsin and all-trans retinal." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0002046 ! opsin binding [Term] id: GO:0016031 name: cytoplasmic tRNA import into mitochondrion namespace: biological_process def: "The directed movement of cytoplasmic tRNA into a mitochondrion." [GOC:ma, PMID:10988073, PMID:11121736] synonym: "cytoplasmic tRNA import into mitochondria" EXACT [] synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT [] synonym: "cytoplasmic tRNA, mitochondrial import" EXACT [] synonym: "mitochondrial import of cytoplasmic tRNA" EXACT [] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0051031 ! tRNA transport [Term] id: GO:0016032 name: viral reproduction namespace: biological_process def: "The process in which a virus reproduces. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:mah] comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'. subset: goslim_pir synonym: "viral infection" RELATED [] synonym: "viral life cycle" EXACT [] synonym: "viral replication cycle" EXACT [] synonym: "virulence" RELATED [] xref: Reactome:162587 "HIV Life Cycle" xref: Reactome:162906 "HIV Infection" xref: Reactome:168255 "Influenza Life Cycle" xref: Wikipedia:Viral_life_cycle is_a: GO:0008150 ! biological_process [Term] id: GO:0016034 name: maleylacetoacetate isomerase activity namespace: molecular_function alt_id: GO:0018841 def: "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2] subset: gosubset_prok synonym: "4-maleylacetoacetate cis-trans-isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetoacetic isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetone cis-trans-isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetone isomerase activity" EXACT [EC:5.2.1.2] xref: EC:5.2.1.2 xref: MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN xref: Reactome:23371 "maleylacetoacetate isomerase activity" xref: UM-BBD_reactionID:r0106 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0016035 name: zeta DNA polymerase complex namespace: cellular_component def: "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0044446 ! intracellular organelle part [Term] id: GO:0016036 name: cellular response to phosphate starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl] subset: gosubset_prok is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0016037 name: light absorption namespace: biological_process def: "The reception of a photon by a cell." [GOC:go_curators] subset: gosubset_prok synonym: "absorption of light" EXACT [GOC:curators] is_a: GO:0009987 ! cellular process relationship: part_of GO:0009583 ! detection of light stimulus [Term] id: GO:0016038 name: absorption of visible light namespace: biological_process def: "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0016037 ! light absorption [Term] id: GO:0016039 name: absorption of UV light namespace: biological_process def: "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0016037 ! light absorption [Term] id: GO:0016040 name: glutamate synthase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH." [EC:1.4.1.14, RHEA:13756] subset: gosubset_prok synonym: "glutamate (reduced nicotinamide adenine dinucleotide) synthase" EXACT [EC:1.4.1.14] synonym: "L-glutamate synthase (NADH)" EXACT [EC:1.4.1.14] synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.14] synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.14] synonym: "L-glutamate:NAD+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.14] synonym: "NADH-dependent glutamate synthase activity" EXACT [EC:1.4.1.14] synonym: "NADH-glutamate synthase activity" EXACT [EC:1.4.1.14] synonym: "NADH: GOGAT" RELATED [EC:1.4.1.14] xref: EC:1.4.1.14 xref: KEGG:R00093 xref: MetaCyc:GLUTAMATE-SYNTHASE-NADH-RXN xref: RHEA:13756 is_a: GO:0045181 ! glutamate synthase activity, NADH or NADPH as acceptor [Term] id: GO:0016041 name: glutamate synthase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+." [EC:1.4.7.1] subset: gosubset_prok synonym: "ferredoxin-dependent glutamate synthase activity" EXACT [EC:1.4.7.1] synonym: "ferredoxin-glutamate synthase activity" EXACT [EC:1.4.7.1] synonym: "glutamate synthase (ferredoxin-dependent)" EXACT [EC:1.4.7.1] synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" EXACT [EC:1.4.7.1] xref: EC:1.4.7.1 xref: MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN xref: MetaCyc:PWY-4341 is_a: GO:0015930 ! glutamate synthase activity is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor [Term] id: GO:0016042 name: lipid catabolic process namespace: biological_process alt_id: GO:0006724 def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] subset: gosubset_prok synonym: "lipid breakdown" EXACT [] synonym: "lipid catabolism" EXACT [] synonym: "lipid degradation" EXACT [] synonym: "lipolysis" EXACT [] xref: Wikipedia:Lipid_catabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:0009056 ! catabolic process [Term] id: GO:0016043 name: cellular component organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0016044 name: cellular membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "membrane organisation" EXACT [GOC:curators] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] xref: Reactome:1253450 "Membrane Trafficking" xref: Reactome:1280388 "Membrane Trafficking" xref: Reactome:1299225 "Membrane Trafficking" xref: Reactome:1326966 "Membrane Trafficking" xref: Reactome:1353061 "Membrane Trafficking" xref: Reactome:1373251 "Membrane Trafficking" xref: Reactome:1393270 "Membrane Trafficking" xref: Reactome:1417761 "Membrane Trafficking" xref: Reactome:1450862 "Membrane Trafficking" xref: Reactome:1471261 "Membrane Trafficking" xref: Reactome:1483236 "Membrane Trafficking" xref: Reactome:1496978 "Membrane Trafficking" xref: Reactome:1514365 "Membrane Trafficking" xref: Reactome:1521238 "Membrane Trafficking" xref: Reactome:1526951 "Membrane Trafficking" xref: Reactome:1532686 "Membrane Trafficking" xref: Reactome:1536099 "Membrane Trafficking" xref: Reactome:199991 "Membrane Trafficking" is_a: GO:0009987 ! cellular process is_a: GO:0061024 ! membrane organization [Term] id: GO:0016045 name: detection of bacterium namespace: biological_process alt_id: GO:0009598 alt_id: GO:0009681 def: "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal." [GOC:hb] synonym: "detection of bacteria" EXACT [] synonym: "perception of bacteria" RELATED [] synonym: "perception of bacterium" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009617 ! response to bacterium [Term] id: GO:0016046 name: detection of fungus namespace: biological_process alt_id: GO:0009599 def: "The series of events in which a stimulus from a fungus is received and converted into a molecular signal." [GOC:hb] synonym: "detection of fungi" EXACT [] synonym: "perception of fungi" RELATED [] synonym: "perception of fungus" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009620 ! response to fungus [Term] id: GO:0016047 name: detection of parasitic fungus namespace: biological_process def: "The series of events in which a stimulus from a parasitic fungus (a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection) is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "detection of parasitic fungi" EXACT [] synonym: "perception of parasitic fungi" RELATED [] synonym: "perception of parasitic fungus" RELATED [] is_a: GO:0009603 ! detection of symbiotic fungus is_a: GO:0009623 ! response to parasitic fungus [Term] id: GO:0016048 name: detection of temperature stimulus namespace: biological_process def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb] synonym: "detection of temperature" EXACT [] synonym: "detection of thermal stimulus" EXACT [] synonym: "perception of temperature" RELATED [] is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0016049 name: cell growth namespace: biological_process alt_id: GO:0048591 def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cell expansion" RELATED [] synonym: "cellular growth" EXACT [] synonym: "growth of cell" EXACT [] synonym: "metabolic process resulting in cell growth" RELATED [] synonym: "metabolism resulting in cell growth" RELATED [] synonym: "non-developmental cell growth" RELATED [GOC:mah] synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0040007 ! growth relationship: part_of GO:0008361 ! regulation of cell size [Term] id: GO:0016050 name: vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vesicle organisation" EXACT [GOC:curators] synonym: "vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0016051 name: carbohydrate biosynthetic process namespace: biological_process alt_id: GO:0006093 def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "anabolic carbohydrate metabolic process" EXACT [] synonym: "anabolic carbohydrate metabolism" EXACT [] synonym: "carbohydrate anabolism" EXACT [] synonym: "carbohydrate biosynthesis" EXACT [] synonym: "carbohydrate formation" EXACT [] synonym: "carbohydrate synthesis" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0009058 ! biosynthetic process [Term] id: GO:0016052 name: carbohydrate catabolic process namespace: biological_process alt_id: GO:0006095 def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "carbohydrate breakdown" EXACT [] synonym: "carbohydrate catabolism" EXACT [] synonym: "carbohydrate degradation" EXACT [] synonym: "catabolic carbohydrate metabolic process" EXACT [] synonym: "catabolic carbohydrate metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0009056 ! catabolic process [Term] id: GO:0016053 name: organic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "organic acid anabolism" EXACT [] synonym: "organic acid biosynthesis" EXACT [] synonym: "organic acid formation" EXACT [] synonym: "organic acid synthesis" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0016054 name: organic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "organic acid breakdown" EXACT [] synonym: "organic acid catabolism" EXACT [] synonym: "organic acid degradation" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0016055 name: Wnt receptor signaling pathway namespace: biological_process alt_id: GO:0007222 def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] synonym: "frizzled signaling pathway" EXACT [] synonym: "frizzled signalling pathway" EXACT [] synonym: "Wg signaling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wg signalling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wingless signaling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wingless signalling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wnt receptor signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0016056 name: rhodopsin mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "rhodopsin mediated signalling pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0016057 name: regulation of membrane potential in photoreceptor cell namespace: biological_process def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0016058 name: maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling namespace: biological_process def: "Maintenance of the excited state of a photoreceptor cell to produce a steady-state current as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "maintenance of rhodopsin mediated signaling" RELATED [] synonym: "maintenance of rhodopsin mediated signalling" EXACT [] is_a: GO:0016057 ! regulation of membrane potential in photoreceptor cell [Term] id: GO:0016059 name: deactivation of rhodopsin mediated signaling namespace: biological_process def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] synonym: "deactivation of rhodopsin mediated signalling" EXACT [] is_a: GO:0022400 ! regulation of rhodopsin mediated signaling pathway relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction [Term] id: GO:0016060 name: metarhodopsin inactivation namespace: biological_process def: "The process in which metarhodopsin is prevented from generating molecular signals." [GOC:hb] is_a: GO:0009968 ! negative regulation of signal transduction relationship: part_of GO:0016059 ! deactivation of rhodopsin mediated signaling [Term] id: GO:0016061 name: regulation of light-activated channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity [Term] id: GO:0016062 name: adaptation of rhodopsin mediated signaling namespace: biological_process def: "The process in which the visual system can modulate its sensitivity and response to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207] synonym: "adaptation of rhodopsin mediated signalling" EXACT [] is_a: GO:0023058 ! adaptation of signaling pathway relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction [Term] id: GO:0016063 name: rhodopsin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "rhodopsin anabolism" EXACT [] synonym: "rhodopsin biosynthesis" EXACT [] synonym: "rhodopsin formation" EXACT [] synonym: "rhodopsin synthesis" EXACT [] is_a: GO:0006726 ! eye pigment biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046154 ! rhodopsin metabolic process [Term] id: GO:0016064 name: immunoglobulin mediated immune response namespace: biological_process def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was improved by GO_REF:0000022. It was renamed and redefined. synonym: "antibody-mediated immune response" EXACT [] is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0016065 name: humoral defense mechanism (sensu Protostomia) namespace: biological_process def: "OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317)." [GOC:add, GOC:jid] comment: This term was made obsolete because antibodies are not found in the taxon Protostomia. synonym: "humoral defence mechanism (sensu Protostomia)" EXACT [] is_obsolete: true [Term] id: GO:0016068 name: type I hypersensitivity namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity. synonym: "immediate hypersensitivity response" EXACT [] xref: Wikipedia:Type_I_hypersensitivity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "RNA metabolism" EXACT [] xref: Reactome:1253462 "Metabolism of RNA" xref: Reactome:1280400 "Metabolism of RNA" xref: Reactome:1299237 "Metabolism of RNA" xref: Reactome:1326978 "Metabolism of RNA" xref: Reactome:1353073 "Metabolism of RNA" xref: Reactome:1373263 "Metabolism of RNA" xref: Reactome:1393282 "Metabolism of RNA" xref: Reactome:1417774 "Metabolism of RNA" xref: Reactome:1450874 "Metabolism of RNA" xref: Reactome:1471265 "Metabolism of RNA" xref: Reactome:1483439 "Metabolism of RNA" xref: Reactome:1497083 "Metabolism of RNA" xref: Reactome:1514470 "Metabolism of RNA" xref: Reactome:1521341 "Metabolism of RNA" xref: Reactome:1527039 "Metabolism of RNA" xref: Reactome:1532772 "Metabolism of RNA" xref: Reactome:1536150 "Metabolism of RNA" xref: Reactome:532600 "Metabolism of RNA" is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0016071 name: mRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pombe subset: gosubset_prok synonym: "mRNA metabolism" EXACT [] xref: Reactome:1253758 "Metabolism of mRNA" xref: Reactome:1280690 "Metabolism of mRNA" xref: Reactome:1299516 "Metabolism of mRNA" xref: Reactome:1327275 "Metabolism of mRNA" xref: Reactome:1353371 "Metabolism of mRNA" xref: Reactome:1373544 "Metabolism of mRNA" xref: Reactome:1393563 "Metabolism of mRNA" xref: Reactome:1418065 "Metabolism of mRNA" xref: Reactome:1451156 "Metabolism of mRNA" xref: Reactome:1471502 "Metabolism of mRNA" xref: Reactome:1483438 "Metabolism of mRNA" xref: Reactome:1497082 "Metabolism of mRNA" xref: Reactome:1514469 "Metabolism of mRNA" xref: Reactome:1521340 "Metabolism of mRNA" xref: Reactome:1527038 "Metabolism of mRNA" xref: Reactome:1532771 "Metabolism of mRNA" xref: Reactome:1536149 "Metabolism of mRNA" xref: Reactome:447010 "Metabolism of mRNA" is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0016072 name: rRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "rRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0016073 name: snRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "snRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0016074 name: snoRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc] synonym: "snoRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0016075 name: rRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai] subset: gosubset_prok synonym: "rRNA breakdown" EXACT [] synonym: "rRNA catabolism" EXACT [] synonym: "rRNA degradation" EXACT [] is_a: GO:0016072 ! rRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016076 name: snRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "snRNA breakdown" EXACT [] synonym: "snRNA catabolism" EXACT [] synonym: "snRNA degradation" EXACT [] is_a: GO:0016073 ! snRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016077 name: snoRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "snoRNA breakdown" EXACT [] synonym: "snoRNA catabolism" EXACT [] synonym: "snoRNA degradation" EXACT [] is_a: GO:0016074 ! snoRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016078 name: tRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai] subset: gosubset_prok synonym: "tRNA breakdown" EXACT [] synonym: "tRNA catabolism" EXACT [] synonym: "tRNA degradation" EXACT [] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016079 name: synaptic vesicle exocytosis namespace: biological_process def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] is_a: GO:0006887 ! exocytosis is_a: GO:0048489 ! synaptic vesicle transport relationship: part_of GO:0007269 ! neurotransmitter secretion [Term] id: GO:0016080 name: synaptic vesicle targeting namespace: biological_process def: "The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah] is_a: GO:0006903 ! vesicle targeting relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016081 name: synaptic vesicle docking involved in exocytosis namespace: biological_process def: "The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342] synonym: "synaptic vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb] is_a: GO:0006904 ! vesicle docking involved in exocytosis relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016082 name: synaptic vesicle priming namespace: biological_process def: "The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016083 name: synaptic vesicle fusion namespace: biological_process def: "OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. is_obsolete: true consider: GO:0016192 [Term] id: GO:0016084 name: myostimulatory hormone activity namespace: molecular_function def: "The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction." [GOC:mah, PMID:12204246] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016085 name: myoinhibitory hormone activity namespace: molecular_function def: "The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction." [GOC:mah, PMID:8902848] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016086 name: allatostatin namespace: molecular_function def: "OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone." [GOC:ai, PMID:10891383] comment: This term was made obsolete because it refers to a gene product. is_obsolete: true consider: GO:0005102 consider: GO:0045968 [Term] id: GO:0016087 name: ecdysiostatic hormone activity namespace: molecular_function def: "The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion." [DOI:10.1002/(SICI)1520-6327(1997)35\:1, GOC:mah] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0016088 name: insulin namespace: molecular_function def: "OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0005102 consider: GO:0045722 consider: GO:0045727 consider: GO:0045935 consider: GO:0046326 consider: GO:0046889 [Term] id: GO:0016090 name: prenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [ISBN:0198547684] subset: gosubset_prok synonym: "prenol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0016091 name: prenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] subset: gosubset_prok synonym: "prenol anabolism" EXACT [] synonym: "prenol biosynthesis" EXACT [] synonym: "prenol formation" EXACT [] synonym: "prenol synthesis" EXACT [] is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0016090 ! prenol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0016092 name: prenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] subset: gosubset_prok synonym: "prenol breakdown" EXACT [] synonym: "prenol catabolism" EXACT [] synonym: "prenol degradation" EXACT [] is_a: GO:0008300 ! isoprenoid catabolic process is_a: GO:0016090 ! prenol metabolic process [Term] id: GO:0016093 name: polyprenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2, ISBN:0198547684] subset: gosubset_prok synonym: "polyprenol metabolism" EXACT [] is_a: GO:0016090 ! prenol metabolic process [Term] id: GO:0016094 name: polyprenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2] subset: gosubset_prok synonym: "polyprenol anabolism" EXACT [] synonym: "polyprenol biosynthesis" EXACT [] synonym: "polyprenol formation" EXACT [] synonym: "polyprenol synthesis" EXACT [] is_a: GO:0016091 ! prenol biosynthetic process is_a: GO:0016093 ! polyprenol metabolic process [Term] id: GO:0016095 name: polyprenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2] subset: gosubset_prok synonym: "polyprenol breakdown" EXACT [] synonym: "polyprenol catabolism" EXACT [] synonym: "polyprenol degradation" EXACT [] is_a: GO:0016092 ! prenol catabolic process is_a: GO:0016093 ! polyprenol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0016098 name: monoterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409, ISBN:0198547684] subset: gosubset_prok synonym: "monoterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016099 name: monoterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409] subset: gosubset_prok synonym: "monoterpenoid anabolism" EXACT [] synonym: "monoterpenoid biosynthesis" EXACT [] synonym: "monoterpenoid formation" EXACT [] synonym: "monoterpenoid synthesis" EXACT [] xref: MetaCyc:PWY-3041 is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016100 name: monoterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409] subset: gosubset_prok synonym: "monoterpenoid breakdown" EXACT [] synonym: "monoterpenoid catabolism" EXACT [] synonym: "monoterpenoid degradation" EXACT [] is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016101 name: diterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." [ISBN:0198547684] subset: gosubset_prok synonym: "diterpene metabolic process" NARROW [] synonym: "diterpene metabolism" NARROW [] synonym: "diterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016102 name: diterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "diterpene biosynthesis" NARROW [] synonym: "diterpene biosynthetic process" NARROW [] synonym: "diterpenoid anabolism" EXACT [] synonym: "diterpenoid biosynthesis" EXACT [] synonym: "diterpenoid formation" EXACT [] synonym: "diterpenoid synthesis" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016103 name: diterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "diterpene catabolic process" NARROW [] synonym: "diterpene catabolism" NARROW [] synonym: "diterpenoid breakdown" EXACT [] synonym: "diterpenoid catabolism" EXACT [] synonym: "diterpenoid degradation" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016104 name: triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] subset: gosubset_prok synonym: "triterpene biosynthesis" NARROW [] synonym: "triterpene biosynthetic process" NARROW [] synonym: "triterpenoid anabolism" EXACT [] synonym: "triterpenoid biosynthesis" EXACT [] synonym: "triterpenoid formation" EXACT [] synonym: "triterpenoid synthesis" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016105 name: triterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] subset: gosubset_prok synonym: "triterpene catabolic process" NARROW [] synonym: "triterpene catabolism" NARROW [] synonym: "triterpenoid breakdown" EXACT [] synonym: "triterpenoid catabolism" EXACT [] synonym: "triterpenoid degradation" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016106 name: sesquiterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] subset: gosubset_prok synonym: "sesquiterpenoid anabolism" EXACT [] synonym: "sesquiterpenoid biosynthesis" EXACT [] synonym: "sesquiterpenoid formation" EXACT [] synonym: "sesquiterpenoid synthesis" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0051762 ! sesquiterpene biosynthetic process [Term] id: GO:0016107 name: sesquiterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] subset: gosubset_prok synonym: "sesquiterpenoid breakdown" EXACT [] synonym: "sesquiterpenoid catabolism" EXACT [] synonym: "sesquiterpenoid degradation" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process is_a: GO:0051763 ! sesquiterpene catabolic process [Term] id: GO:0016108 name: tetraterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units." [ISBN:0198547684] subset: gosubset_prok synonym: "tetraterpene metabolic process" NARROW [] synonym: "tetraterpene metabolism" NARROW [] synonym: "tetraterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016109 name: tetraterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] subset: gosubset_prok synonym: "tetraterpene biosynthesis" NARROW [] synonym: "tetraterpene biosynthetic process" NARROW [] synonym: "tetraterpenoid anabolism" EXACT [] synonym: "tetraterpenoid biosynthesis" EXACT [] synonym: "tetraterpenoid formation" EXACT [] synonym: "tetraterpenoid synthesis" EXACT [] is_a: GO:0016108 ! tetraterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016110 name: tetraterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] subset: gosubset_prok synonym: "tetraterpene catabolic process" NARROW [] synonym: "tetraterpene catabolism" NARROW [] synonym: "tetraterpenoid breakdown" EXACT [] synonym: "tetraterpenoid catabolism" EXACT [] synonym: "tetraterpenoid degradation" EXACT [] is_a: GO:0016108 ! tetraterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016111 name: polyterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units." [ISBN:0198547684] subset: gosubset_prok synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] synonym: "polyterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016112 name: polyterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] subset: gosubset_prok synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] synonym: "polyterpenoid anabolism" EXACT [] synonym: "polyterpenoid biosynthesis" EXACT [] synonym: "polyterpenoid formation" EXACT [] synonym: "polyterpenoid synthesis" EXACT [] is_a: GO:0016111 ! polyterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016113 name: polyterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] subset: gosubset_prok synonym: "polyterpene catabolic process" NARROW [] synonym: "polyterpene catabolism" NARROW [] synonym: "polyterpenoid breakdown" EXACT [] synonym: "polyterpenoid catabolism" EXACT [] synonym: "polyterpenoid degradation" EXACT [] is_a: GO:0016111 ! polyterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016114 name: terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] subset: gosubset_prok synonym: "terpenoid anabolism" EXACT [] synonym: "terpenoid biosynthesis" EXACT [] synonym: "terpenoid formation" EXACT [] synonym: "terpenoid synthesis" EXACT [] xref: Wikipedia:Terpenoid is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008299 ! isoprenoid biosynthetic process [Term] id: GO:0016115 name: terpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] subset: gosubset_prok synonym: "terpenoid breakdown" EXACT [] synonym: "terpenoid catabolism" EXACT [] synonym: "terpenoid degradation" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008300 ! isoprenoid catabolic process [Term] id: GO:0016116 name: carotenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684] subset: gosubset_prok synonym: "carotenoid metabolism" EXACT [] is_a: GO:0016108 ! tetraterpenoid metabolic process [Term] id: GO:0016117 name: carotenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] subset: gosubset_prok synonym: "carotenoid anabolism" EXACT [] synonym: "carotenoid biosynthesis" EXACT [] synonym: "carotenoid formation" EXACT [] synonym: "carotenoid synthesis" EXACT [] xref: MetaCyc:CAROTENOID-PWY is_a: GO:0016109 ! tetraterpenoid biosynthetic process is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0016118 name: carotenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] subset: gosubset_prok synonym: "carotenoid breakdown" EXACT [] synonym: "carotenoid catabolism" EXACT [] synonym: "carotenoid degradation" EXACT [] is_a: GO:0016110 ! tetraterpenoid catabolic process is_a: GO:0016116 ! carotenoid metabolic process [Term] id: GO:0016119 name: carotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684] subset: gosubset_prok synonym: "carotene metabolism" EXACT [] is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0016120 name: carotene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids." [GOC:go_curators] subset: gosubset_prok synonym: "carotene anabolism" EXACT [] synonym: "carotene biosynthesis" EXACT [] synonym: "carotene formation" EXACT [] synonym: "carotene synthesis" EXACT [] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:0016119 ! carotene metabolic process is_a: GO:0046246 ! terpene biosynthetic process [Term] id: GO:0016121 name: carotene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids." [GOC:go_curators] subset: gosubset_prok synonym: "carotene breakdown" EXACT [] synonym: "carotene catabolism" EXACT [] synonym: "carotene degradation" EXACT [] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:0016119 ! carotene metabolic process is_a: GO:0046247 ! terpene catabolic process [Term] id: GO:0016122 name: xanthophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684] subset: gosubset_prok synonym: "xanthophyll metabolism" EXACT [] is_a: GO:0016116 ! carotenoid metabolic process [Term] id: GO:0016123 name: xanthophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] subset: gosubset_prok synonym: "xanthophyll anabolism" EXACT [] synonym: "xanthophyll biosynthesis" EXACT [] synonym: "xanthophyll formation" EXACT [] synonym: "xanthophyll synthesis" EXACT [] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0016124 name: xanthophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] subset: gosubset_prok synonym: "xanthophyll breakdown" EXACT [] synonym: "xanthophyll catabolism" EXACT [] synonym: "xanthophyll degradation" EXACT [] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0016125 name: sterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684] subset: gosubset_prok synonym: "sterol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0008202 ! steroid metabolic process [Term] id: GO:0016126 name: sterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] subset: gosubset_prok synonym: "sterol anabolism" EXACT [] synonym: "sterol biosynthesis" EXACT [] synonym: "sterol formation" EXACT [] synonym: "sterol synthesis" EXACT [] xref: MetaCyc:PWY-2541 is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0016125 ! sterol metabolic process [Term] id: GO:0016127 name: sterol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] subset: gosubset_prok synonym: "sterol breakdown" EXACT [] synonym: "sterol catabolism" EXACT [] synonym: "sterol degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0016125 ! sterol metabolic process [Term] id: GO:0016128 name: phytosteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "phytosteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process [Term] id: GO:0016129 name: phytosteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah, ISBN:0471331309 "Biochemical Pathways"] subset: gosubset_prok synonym: "phytosteroid anabolism" EXACT [] synonym: "phytosteroid biosynthesis" EXACT [] synonym: "phytosteroid formation" EXACT [] synonym: "phytosteroid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0016128 ! phytosteroid metabolic process [Term] id: GO:0016130 name: phytosteroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah] subset: gosubset_prok synonym: "phytosteroid breakdown" EXACT [] synonym: "phytosteroid catabolism" EXACT [] synonym: "phytosteroid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0016128 ! phytosteroid metabolic process [Term] id: GO:0016131 name: brassinosteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] subset: gosubset_prok synonym: "brassinosteroid metabolism" EXACT [] is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0016132 name: brassinosteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] subset: gosubset_prok synonym: "brassinosteroid anabolism" EXACT [] synonym: "brassinosteroid biosynthesis" EXACT [] synonym: "brassinosteroid formation" EXACT [] synonym: "brassinosteroid synthesis" EXACT [] xref: MetaCyc:PWY-2582 xref: MetaCyc:PWY-699 is_a: GO:0016129 ! phytosteroid biosynthetic process is_a: GO:0016131 ! brassinosteroid metabolic process is_a: GO:0042446 ! hormone biosynthetic process [Term] id: GO:0016133 name: brassinosteroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] subset: gosubset_prok synonym: "brassinosteroid breakdown" EXACT [] synonym: "brassinosteroid catabolism" EXACT [] synonym: "brassinosteroid degradation" EXACT [] is_a: GO:0016130 ! phytosteroid catabolic process is_a: GO:0016131 ! brassinosteroid metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0016134 name: saponin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [ISBN:0198547684] subset: gosubset_prok synonym: "saponin metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0016135 name: saponin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] subset: gosubset_prok synonym: "saponin anabolism" EXACT [] synonym: "saponin biosynthesis" EXACT [] synonym: "saponin formation" EXACT [] synonym: "saponin synthesis" EXACT [] is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0016129 ! phytosteroid biosynthetic process is_a: GO:0016134 ! saponin metabolic process is_a: GO:0016138 ! glycoside biosynthetic process [Term] id: GO:0016136 name: saponin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] subset: gosubset_prok synonym: "saponin breakdown" EXACT [] synonym: "saponin catabolism" EXACT [] synonym: "saponin degradation" EXACT [] is_a: GO:0016115 ! terpenoid catabolic process is_a: GO:0016130 ! phytosteroid catabolic process is_a: GO:0016134 ! saponin metabolic process is_a: GO:0016139 ! glycoside catabolic process [Term] id: GO:0016137 name: glycoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [ISBN:0198547684] subset: gosubset_prok synonym: "glycoside metabolism" EXACT [] is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0016138 name: glycoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] subset: gosubset_prok synonym: "glycoside anabolism" EXACT [] synonym: "glycoside biosynthesis" EXACT [] synonym: "glycoside formation" EXACT [] synonym: "glycoside synthesis" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process [Term] id: GO:0016139 name: glycoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] subset: gosubset_prok synonym: "glycoside breakdown" EXACT [] synonym: "glycoside catabolism" EXACT [] synonym: "glycoside degradation" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0016140 name: O-glycoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "O-glycoside metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0016141 name: O-glycoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "O-glycoside anabolism" EXACT [] synonym: "O-glycoside biosynthesis" EXACT [] synonym: "O-glycoside formation" EXACT [] synonym: "O-glycoside synthesis" EXACT [] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0016140 ! O-glycoside metabolic process [Term] id: GO:0016142 name: O-glycoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "O-glycoside breakdown" EXACT [] synonym: "O-glycoside catabolism" EXACT [] synonym: "O-glycoside degradation" EXACT [] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0016140 ! O-glycoside metabolic process [Term] id: GO:0016143 name: S-glycoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "S-glycoside metabolism" EXACT [] synonym: "thioglycoside metabolic process" EXACT [] synonym: "thioglycoside metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0016144 name: S-glycoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "S-glycoside anabolism" EXACT [] synonym: "S-glycoside biosynthesis" EXACT [] synonym: "S-glycoside formation" EXACT [] synonym: "S-glycoside synthesis" EXACT [] synonym: "thioglycoside biosynthesis" EXACT [] synonym: "thioglycoside biosynthetic process" EXACT [] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0016145 name: S-glycoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "S-glycoside breakdown" EXACT [] synonym: "S-glycoside catabolism" EXACT [] synonym: "S-glycoside degradation" EXACT [] synonym: "thioglycoside catabolic process" EXACT [] synonym: "thioglycoside catabolism" EXACT [] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0016146 name: protein-synthesizing GTPase activity, initiation namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] comment: This term was made obsolete because it contains both process and function information. is_obsolete: true replaced_by: GO:0003743 replaced_by: GO:0003924 replaced_by: GO:0006412 replaced_by: GO:0006413 [Term] id: GO:0016147 name: protein-synthesizing GTPase activity, elongation namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] comment: This term was made obsolete because it contains both process and function information. is_obsolete: true replaced_by: GO:0003746 replaced_by: GO:0003924 replaced_by: GO:0006412 replaced_by: GO:0006414 [Term] id: GO:0016148 name: protein-synthesizing GTPase activity, termination namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] comment: This term was made obsolete because it contains both process and function information. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0006412 replaced_by: GO:0006415 replaced_by: GO:0008079 [Term] id: GO:0016149 name: translation release factor activity, codon specific namespace: molecular_function def: "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684] subset: gosubset_prok is_a: GO:0003747 ! translation release factor activity [Term] id: GO:0016150 name: translation release factor activity, codon nonspecific namespace: molecular_function def: "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684] is_a: GO:0003747 ! translation release factor activity [Term] id: GO:0016151 name: nickel ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with nickel (Ni) ions." [GOC:ai] subset: gosubset_prok synonym: "nickel binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0016152 name: mercury (II) reductase activity namespace: molecular_function alt_id: GO:0018692 def: "Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH." [EC:1.16.1.1, RHEA:23859] subset: gosubset_prok synonym: "Hg:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.1] synonym: "mer A" RELATED [EC:1.16.1.1] synonym: "mercurate(II) reductase activity" EXACT [EC:1.16.1.1] synonym: "mercuric ion reductase activity" EXACT [EC:1.16.1.1] synonym: "mercuric reductase activity" EXACT [EC:1.16.1.1] synonym: "mercury reductase activity" EXACT [EC:1.16.1.1] synonym: "mercury(II) reductase activity" EXACT [EC:1.16.1.1] synonym: "reduced NADP:mercuric ion oxidoreductase activity" EXACT [EC:1.16.1.1] xref: EC:1.16.1.1 xref: KEGG:R02807 xref: MetaCyc:MERCURY-II-REDUCTASE-RXN xref: RHEA:23859 xref: UM-BBD_reactionID:r0406 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0016153 name: urocanate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O." [EC:4.2.1.49, RHEA:13104] subset: gosubset_prok synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)" EXACT [EC:4.2.1.49] synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity" EXACT [EC:4.2.1.49] synonym: "imidazolonepropionate hydrolase activity" EXACT [EC:4.2.1.49] synonym: "urocanase activity" EXACT [EC:4.2.1.49] xref: EC:4.2.1.49 xref: KEGG:R02914 xref: MetaCyc:UROCANATE-HYDRATASE-RXN xref: Reactome:23891 "urocanate hydratase activity" xref: RHEA:13104 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0016154 name: pyrimidine-nucleoside phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2] subset: gosubset_prok synonym: "Py-NPase activity" EXACT [EC:2.4.2.2] synonym: "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.2] xref: EC:2.4.2.2 xref: MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0016155 name: formyltetrahydrofolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH." [EC:1.5.1.6, RHEA:10183] synonym: "10-formyl tetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "10-formyl-H2PtGlu:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "10-formyl-H4folate dehydrogenase activity" EXACT [EC:1.5.1.6] synonym: "10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] synonym: "10-formyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "N10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] xref: EC:1.5.1.6 xref: KEGG:R00941 xref: MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN xref: RHEA:10183 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0016156 name: fumarate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + succinate = fumarate + H(+) + NADH." [EC:1.3.1.6, RHEA:18284] subset: gosubset_prok synonym: "NADH-dependent fumarate reductase activity" EXACT [EC:1.3.1.6] synonym: "NADH-fumarate reductase activity" EXACT [EC:1.3.1.6] synonym: "succinate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.6] xref: EC:1.3.1.6 xref: KEGG:R00402 xref: MetaCyc:FUMARATE-REDUCTASE-NADH-RXN xref: RHEA:18284 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016157 name: sucrose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." [EC:2.4.1.13] subset: gosubset_prok synonym: "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "sucrose synthetase activity" EXACT [EC:2.4.1.13] synonym: "sucrose-UDP glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "sucrose-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "UDP-glucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "UDPglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "uridine diphosphoglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] xref: EC:2.4.1.13 xref: MetaCyc:SUCROSE-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0016158 name: 3-phytase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8] subset: gosubset_prok synonym: "1-phytase activity" EXACT [EC:3.1.3.8] synonym: "myo-inositol-hexakisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.8] synonym: "myo-inositol-hexaphosphate 3-phosphohydrolase activity" EXACT [] synonym: "phytase activity" BROAD [] synonym: "phytate 1-phosphatase activity" EXACT [EC:3.1.3.8] synonym: "phytate 3-phosphatase activity" EXACT [] xref: EC:3.1.3.8 xref: MetaCyc:RXN0-1001 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0016159 name: muconolactone delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate." [EC:5.3.3.4] subset: gosubset_prok synonym: "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.4] synonym: "muconolactone D-isomerase activity" EXACT [] synonym: "muconolactone isomerase activity" EXACT [EC:5.3.3.4] xref: EC:5.3.3.4 xref: MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0016160 name: amylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of amylose or an amylose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016161 name: beta-amylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [EC:3.2.1.2] subset: gosubset_prok synonym: "1,4-alpha-D-glucan maltohydrolase activity" EXACT [EC:3.2.1.2] synonym: "beta amylase activity" EXACT [EC:3.2.1.2] synonym: "glycogenase activity" BROAD [EC:3.2.1.2] synonym: "saccharogen amylase activity" EXACT [EC:3.2.1.2] xref: EC:3.2.1.2 xref: MetaCyc:RXN-1827 is_a: GO:0016160 ! amylase activity [Term] id: GO:0016162 name: cellulose 1,4-beta-cellobiosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] subset: gosubset_prok synonym: "1,4-beta-cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "1,4-beta-D-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "1,4-beta-glucan cellobiosidase activity" EXACT [EC:3.2.1.91] synonym: "avicelase activity" BROAD [EC:3.2.1.91] synonym: "beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "beta-1,4-glucan cellobiosylhydrolase activity" EXACT [EC:3.2.1.91] synonym: "C1 cellulase activity" EXACT [EC:3.2.1.91] synonym: "CBH 1" RELATED [EC:3.2.1.91] synonym: "cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "cellobiohydrolase I" RELATED [EC:3.2.1.91] synonym: "cellobiosidase activity" EXACT [EC:3.2.1.91] synonym: "exo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.91] synonym: "exo-beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exo-cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exocellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exoglucanase activity" EXACT [EC:3.2.1.91] xref: EC:3.2.1.91 xref: MetaCyc:3.2.1.91-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016163 name: nitrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] subset: gosubset_prok synonym: "iron-iron nitrogenase activity" NARROW [] synonym: "molybdenum-iron nitrogenase activity" NARROW [] synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity" EXACT [EC:1.18.6.1] synonym: "vanadium-iron nitrogenase activity" NARROW [] xref: EC:1.18.6.1 xref: MetaCyc:NITROGENASE-RXN xref: UM-BBD_enzymeID:e0395 is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor [Term] id: GO:0016164 name: Mo-molybdopterin oxidoreductase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the differentia from the parent is a gene product feature (specifically, the presence of a molybdopterin cofactor in the protein). It has also never been defined. subset: gosubset_prok synonym: "molybdopterin oxidoreductase activity" EXACT [] is_obsolete: true replaced_by: GO:0016491 [Term] id: GO:0016165 name: lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12] subset: gosubset_prok synonym: "carotene oxidase activity" NARROW [EC:1.13.11.12] synonym: "fat oxidase activity" EXACT [EC:1.13.11.12] synonym: "linoleate:oxygen 13-oxidoreductase activity" EXACT [EC:1.13.11.12] synonym: "lionoleate:O2 oxidoreductase activity" EXACT [EC:1.13.11.12] synonym: "lipoperoxidase activity" EXACT [EC:1.13.11.12] synonym: "lipoxidase activity" EXACT [EC:1.13.11.12] synonym: "lipoxydase activity" EXACT [EC:1.13.11.12] xref: EC:1.13.11.12 xref: MetaCyc:LIPOXYGENASE-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0016166 name: phytoene dehydrogenase activity namespace: molecular_function def: "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/terp/carot.html] subset: gosubset_prok xref: EC:1.3.-.- is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016167 name: glial cell-derived neurotrophic factor receptor activity namespace: molecular_function def: "Combining with glial cell line-derived neurotrophic factor to initiate a change in cell activity." [GOC:mah] synonym: "GDNF receptor activity" EXACT [GOC:mah] synonym: "glial cell line-derived neurotrophic factor receptor activity" EXACT [GOC:bf] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0016168 name: chlorophyll binding namespace: molecular_function def: "Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] subset: gosubset_prok is_a: GO:0046906 ! tetrapyrrole binding [Term] id: GO:0016169 name: bacteriochlorophyll c binding namespace: molecular_function def: "Interacting selectively and non-covalently with bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981] subset: gosubset_prok is_a: GO:0042314 ! bacteriochlorophyll binding [Term] id: GO:0016170 name: interleukin-15 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-15 receptor." [GOC:ai] synonym: "IL-15" NARROW [] synonym: "interleukin-15 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0016171 name: cell surface antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true [Term] id: GO:0016172 name: antifreeze activity namespace: molecular_function def: "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures." [GOC:jl] comment: This term was made obsolete because it refers to a biological process. is_obsolete: true consider: GO:0042309 consider: GO:0050825 consider: GO:0050826 [Term] id: GO:0016173 name: ice nucleation inhibitor activity namespace: molecular_function def: "OBSOLETE. Inhibits the formation of ice crystals." [GOC:ai] comment: This term was made obsolete because it refers to a biological process. is_obsolete: true consider: GO:0042309 consider: GO:0050825 consider: GO:0050826 [Term] id: GO:0016174 name: NAD(P)H oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1] synonym: "dual oxidase activity" RELATED [EC:1.6.3.1] synonym: "NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.6.3.1] synonym: "NADPH oxidase" BROAD [EC:1.6.3.1] synonym: "p138tox" RELATED [EC:1.6.3.1] synonym: "ThOX activity" NARROW [EC:1.6.3.1] synonym: "THOX2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid NADPH oxidase activity" NARROW [] synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1] xref: EC:1.6.3.1 is_a: GO:0050664 ! oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor [Term] id: GO:0016175 name: superoxide-generating NADPH oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195] synonym: "cytochrome B-245" RELATED [] xref: EC:1.6.3.- is_a: GO:0050664 ! oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor [Term] id: GO:0016176 name: superoxide-generating NADPH oxidase activator activity namespace: molecular_function def: "Increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai] synonym: "neutrophil cytosol factor 2" NARROW [] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0016180 name: snRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl] is_a: GO:0016073 ! snRNA metabolic process is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0016182 name: synaptic vesicle budding from endosome namespace: biological_process def: "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [GOC:curators, PMID:10099709] synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah] synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah] is_a: GO:0016197 ! endosome transport is_a: GO:0070142 ! synaptic vesicle budding relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016183 name: synaptic vesicle coating namespace: biological_process def: "A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709] is_a: GO:0006901 ! vesicle coating relationship: part_of GO:0016185 ! synaptic vesicle budding from presynaptic membrane [Term] id: GO:0016184 name: synaptic vesicle retrieval namespace: biological_process def: "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. is_obsolete: true consider: GO:0016192 [Term] id: GO:0016185 name: synaptic vesicle budding from presynaptic membrane namespace: biological_process def: "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709] synonym: "synaptic vesicle budding involved in synaptic vesicle endocytosis" EXACT [GOC:mah] is_a: GO:0070142 ! synaptic vesicle budding relationship: part_of GO:0048488 ! synaptic vesicle endocytosis [Term] id: GO:0016186 name: synaptic vesicle fission namespace: biological_process def: "OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. is_obsolete: true consider: GO:0016192 [Term] id: GO:0016187 name: synaptic vesicle internalization namespace: biological_process def: "OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. is_obsolete: true consider: GO:0016192 [Term] id: GO:0016188 name: synaptic vesicle maturation namespace: biological_process def: "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [GOC:curators, PMID:10099709] is_a: GO:0016050 ! vesicle organization is_a: GO:0021700 ! developmental maturation relationship: part_of GO:0048488 ! synaptic vesicle endocytosis [Term] id: GO:0016189 name: synaptic vesicle to endosome fusion namespace: biological_process def: "Fusion of a synaptic vesicle with the membrane of an endosome." [GOC:curators, PMID:10099709] synonym: "synaptic vesicle fusion" BROAD [] is_a: GO:0006944 ! cellular membrane fusion is_a: GO:0016197 ! endosome transport is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0048488 ! synaptic vesicle endocytosis [Term] id: GO:0016191 name: synaptic vesicle uncoating namespace: biological_process def: "The removal of the protein coat on a synaptic vesicle." [GOC:curators, PMID:10099709] subset: gosubset_prok synonym: "synaptic vesicle coat depolymerization" EXACT [] synonym: "synaptic vesicle coat protein depolymerization" EXACT [] is_a: GO:0072319 ! vesicle uncoating relationship: part_of GO:0048488 ! synaptic vesicle endocytosis [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process [Term] id: GO:0016197 name: endosome transport namespace: biological_process def: "The directed movement of substances into, out of or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Reactome:917729 "Endosomal Sorting Complex Required For Transport (ESCRT)" is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0016198 name: axon choice point recognition namespace: biological_process def: "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152] is_a: GO:0008038 ! neuron recognition relationship: part_of GO:0007411 ! axon guidance [Term] id: GO:0016199 name: axon midline choice point recognition namespace: biological_process def: "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] is_a: GO:0016198 ! axon choice point recognition [Term] id: GO:0016200 name: synaptic target attraction namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0008039 ! synaptic target recognition [Term] id: GO:0016201 name: synaptic target inhibition namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0008039 ! synaptic target recognition [Term] id: GO:0016202 name: regulation of striated muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] is_a: GO:0048634 ! regulation of muscle organ development relationship: regulates GO:0014706 ! striated muscle tissue development [Term] id: GO:0016203 name: muscle attachment namespace: biological_process def: "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] is_a: GO:0032502 ! developmental process relationship: part_of GO:0060538 ! skeletal muscle organ development [Term] id: GO:0016204 name: determination of muscle attachment site namespace: biological_process def: "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0016203 ! muscle attachment [Term] id: GO:0016205 name: selenocysteine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.-, PMID:10026151] xref: EC:2.1.1.- is_a: GO:0051995 ! Se-methyltransferase activity [Term] id: GO:0016206 name: catechol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol." [EC:2.1.1.6] subset: gosubset_prok synonym: "catechol methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "catecholamine O-methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "COMT I" RELATED [EC:2.1.1.6] synonym: "COMT II" RELATED [EC:2.1.1.6] synonym: "MB-COMT (membrane-bound form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] synonym: "S-adenosyl-L-methionine:catechol O-methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] xref: EC:2.1.1.6 xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN xref: Reactome:24294 "catechol O-methyltransferase activity" is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016207 name: 4-coumarate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12] subset: gosubset_prok synonym: "4-coumarate-CoA synthetase activity" EXACT [] synonym: "4-coumarate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.12] synonym: "4-coumarate:CoA ligase activity" EXACT [] synonym: "4-coumarate:coenzyme A ligase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaroyl-CoA synthase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaroyl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "4CL" RELATED [EC:6.2.1.12] synonym: "caffeolyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "feruloyl CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "feruloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "hydroxycinnamate:CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "hydroxycinnamoyl CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaroyl CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl-CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-hydroxycinnamic acid:CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-hydroxycinnamoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "sinapoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] xref: EC:6.2.1.12 xref: KEGG:R01616 xref: MetaCyc:4-COUMARATE--COA-LIGASE-RXN xref: RHEA:19644 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0016208 name: AMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators] subset: gosubset_prok is_a: GO:0032559 ! adenyl ribonucleotide binding [Term] id: GO:0016209 name: antioxidant activity namespace: molecular_function def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0003674 ! molecular_function [Term] id: GO:0016210 name: naringenin-chalcone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74] subset: gosubset_prok synonym: "chalcone synthase activity" EXACT [EC:2.3.1.74] synonym: "chalcone synthetase activity" EXACT [] synonym: "CHS" EXACT [] synonym: "DOCS" NARROW [] synonym: "flavanone synthase activity" EXACT [EC:2.3.1.74] synonym: "flavonone synthase activity" EXACT [EC:2.3.1.74] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.74] xref: EC:2.3.1.74 xref: MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016211 name: ammonia ligase activity namespace: molecular_function def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok xref: EC:6.3.1.- is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0016212 name: kynurenine-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7] subset: gosubset_prok synonym: "kynurenine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine transaminase (cyclizing)" EXACT [EC:2.6.1.7] synonym: "kynurenine--oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine-oxoglutarate aminotransferase activity" EXACT [] synonym: "L-kynurenine aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "L-kynurenine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] xref: EC:2.6.1.7 xref: MetaCyc:2.6.1.7-RXN xref: Reactome:24302 "kynurenine-oxoglutarate transaminase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0016213 name: linoleoyl-CoA desaturase activity namespace: molecular_function def: "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O." [EC:1.14.19.3] comment: Note that this function was formerly EC:1.14.99.25. subset: gosubset_prok synonym: "delta(6)-acyl CoA desaturase activity" BROAD [] synonym: "delta(6)-desaturase activity" BROAD [] synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD [] synonym: "delta6-acyl CoA desaturase activity" EXACT [EC:1.14.19.3] synonym: "delta6-desaturase activity" EXACT [EC:1.14.19.3] synonym: "delta6-fatty acyl-CoA desaturase activity" EXACT [EC:1.14.19.3] synonym: "fatty acid 6-desaturase activity" BROAD [] synonym: "fatty acid delta(6)-desaturase activity" BROAD [] synonym: "fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] synonym: "linoleate desaturase activity" RELATED [] synonym: "linoleic acid desaturase activity" RELATED [] synonym: "linoleic desaturase activity" RELATED [] synonym: "linoleoyl CoA desaturase activity" EXACT [] synonym: "linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.3] synonym: "linoleoyl-coenzyme A desaturase activity" EXACT [] synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD [] synonym: "long-chain fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] xref: EC:1.14.19.3 xref: MetaCyc:1.14.19.3-RXN is_a: GO:0016215 ! CoA desaturase activity [Term] id: GO:0016215 name: CoA desaturase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.1, EC:1.14.19.5, GOC:mah] subset: gosubset_prok xref: EC:1.14.19.- is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0016216 name: isopenicillin-N synthase activity namespace: molecular_function def: "Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N." [EC:1.21.3.1, RHEA:22431] subset: gosubset_prok synonym: "isopenicillin N synthase activity" EXACT [EC:1.21.3.1] synonym: "isopenicillin-N synthetase activity" EXACT [] synonym: "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.1] xref: EC:1.21.3.1 xref: KEGG:R04872 xref: MetaCyc:1.21.3.1-RXN xref: RHEA:22431 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0016217 name: N-ethylammeline chlorohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+." [MetaCyc:R465-RXN] xref: MetaCyc:R465-RXN is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016218 name: polyketide synthase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators] comment: This term was made obsolete because the activity it describes does not exist, and the gene product with the name 'polyketide synthase' has multiple functional domains, so using the name to describe a single function would be misleading. is_obsolete: true replaced_by: GO:0030639 consider: GO:0034081 [Term] id: GO:0016222 name: procollagen-proline 4-dioxygenase complex namespace: cellular_component def: "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822] synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex" EXACT [EC:1.14.11.2] synonym: "prolyl 4-hydroxylase complex" BROAD [EC:1.14.11.2] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0016223 name: beta-alanine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine." [EC:2.6.1.18] subset: gosubset_prok synonym: "beta-alanine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] synonym: "beta-alanine-alpha-alanine transaminase activity" EXACT [EC:2.6.1.18] synonym: "beta-alanine-pyruvate aminotransferase activity" EXACT [] synonym: "L-alanine:3-oxopropanoate aminotransferase activity" EXACT [EC:2.6.1.18] synonym: "omega-amino acid--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] xref: EC:2.6.1.18 xref: MetaCyc:2.6.1.18-RXN xref: Reactome:24328 "beta-alanine-pyruvate transaminase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0016226 name: iron-sulfur cluster assembly namespace: biological_process def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:mah] subset: gosubset_prok synonym: "iron-sulfur cluster biosynthesis" EXACT [] synonym: "iron-sulphur cluster assembly" EXACT [] is_a: GO:0031163 ! metallo-sulfur cluster assembly [Term] id: GO:0016227 name: tRNA sulfurtransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4] comment: This term was made obsolete because tRNA thionucleotide formation is a multistep process; there is no single reaction in which cysteine reacts with an activated tRNA directly synonym: "L-cysteine:tRNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer RNA thiolase activity" EXACT [EC:2.8.1.4] synonym: "tRNA sulphurtransferase activity" EXACT [] xref: EC:2.8.1.4 xref: MetaCyc:TRNA-S-TRANSFERASE-RXN is_obsolete: true replaced_by: GO:0034227 consider: GO:0016783 [Term] id: GO:0016229 name: steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah] subset: gosubset_prok xref: EC:1.1.1.- is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016230 name: sphingomyelin phosphodiesterase activator activity namespace: molecular_function def: "Increases the activity of the enzyme sphingomyelin phosphodiesterase." [GOC:ai] synonym: "neutral sphingomyelinase activator" EXACT [] is_a: GO:0016004 ! phospholipase activator activity [Term] id: GO:0016231 name: beta-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN] is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity [Term] id: GO:0016232 name: HNK-1 sulfotransferase activity namespace: molecular_function def: "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R)." [PMID:9478973] synonym: "HNK-1 sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0016233 name: telomere capping namespace: biological_process def: "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] synonym: "telomere end protection" EXACT [] xref: Reactome:1263254 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure" xref: Reactome:1263486 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure" xref: Reactome:1287792 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure" xref: Reactome:1287999 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure" xref: Reactome:1309627 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure" xref: Reactome:1309903 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure" xref: Reactome:1336566 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure" xref: Reactome:1336864 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure" xref: Reactome:1360528 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure" xref: Reactome:1360798 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure" xref: Reactome:176700 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure" xref: Reactome:181450 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure" is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0016234 name: inclusion body namespace: cellular_component def: "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744] xref: Wikipedia:Inclusion_bodies is_a: GO:0044424 ! intracellular part [Term] id: GO:0016235 name: aggresome namespace: cellular_component def: "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744] xref: Wikipedia:Aggresome is_a: GO:0016234 ! inclusion body [Term] id: GO:0016236 name: macroautophagy namespace: biological_process alt_id: GO:0034262 def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:9412464] synonym: "autophagy in response to cellular starvation" EXACT [] synonym: "non-specific autophagy" EXACT [] synonym: "starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006914 ! autophagy is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0016237 name: microautophagy namespace: biological_process def: "The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment." [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964] is_a: GO:0006914 ! autophagy is_a: GO:0010324 ! membrane invagination [Term] id: GO:0016239 name: positive regulation of macroautophagy namespace: biological_process def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] synonym: "activation of macroautophagy" NARROW [] synonym: "positive regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "stimulation of macroautophagy" NARROW [] synonym: "up regulation of macroautophagy" EXACT [] synonym: "up-regulation of macroautophagy" EXACT [] synonym: "upregulation of macroautophagy" EXACT [] is_a: GO:0010508 ! positive regulation of autophagy is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0016241 ! regulation of macroautophagy is_a: GO:0032109 ! positive regulation of response to nutrient levels relationship: positively_regulates GO:0016236 ! macroautophagy [Term] id: GO:0016240 name: autophagic vacuole docking namespace: biological_process def: "The initial attachment of an autophagic vacuole membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:mah] is_a: GO:0022406 ! membrane docking relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0016241 name: regulation of macroautophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0016236 ! macroautophagy [Term] id: GO:0016242 name: negative regulation of macroautophagy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] synonym: "down regulation of macroautophagy" EXACT [] synonym: "down-regulation of macroautophagy" EXACT [] synonym: "downregulation of macroautophagy" EXACT [] synonym: "inhibition of macroautophagy" NARROW [] synonym: "negative regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010507 ! negative regulation of autophagy is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0016241 ! regulation of macroautophagy is_a: GO:0032108 ! negative regulation of response to nutrient levels relationship: negatively_regulates GO:0016236 ! macroautophagy [Term] id: GO:0016243 name: regulation of autophagic vacuole size namespace: biological_process def: "Any process that modulates the size of the autophagic vacuole." [GOC:krc] is_a: GO:0032535 ! regulation of cellular component size relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0016246 name: RNA interference namespace: biological_process def: "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'. synonym: "posttranscriptional gene silencing by siRNA" EXACT [GOC:mah] synonym: "RNAi" EXACT [] xref: Wikipedia:RNA_interference is_a: GO:0035194 ! posttranscriptional gene silencing by RNA [Term] id: GO:0016247 name: channel regulator activity namespace: molecular_function def: "Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah] subset: gosubset_prok is_a: GO:0003674 ! molecular_function [Term] id: GO:0016248 name: channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah] subset: gosubset_prok is_a: GO:0016247 ! channel regulator activity [Term] id: GO:0016250 name: N-sulfoglucosamine sulfohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate." [EC:3.10.1.1] synonym: "2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)" EXACT [EC:3.10.1.1] synonym: "heparin sulfamidase activity" EXACT [EC:3.10.1.1] synonym: "N-sulfo-D-glucosamine sulfohydrolase activity" EXACT [EC:3.10.1.1] synonym: "N-sulphoglucosamine sulphohydrolase activity" EXACT [] synonym: "sulfoglucosamine sulfamidase activity" EXACT [EC:3.10.1.1] synonym: "sulphamidase activity" EXACT [EC:3.10.1.1] xref: EC:3.10.1.1 xref: MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds [Term] id: GO:0016251 name: general RNA polymerase II transcription factor activity namespace: molecular_function alt_id: GO:0003703 def: "OBSOLETE. Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF)." [PMID:10384286, PMID:9774831] comment: To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0000981 consider: GO:0000991 consider: GO:0001076 consider: GO:0006366 [Term] id: GO:0016252 name: nonspecific RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl] comment: To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0000981 consider: GO:0000991 consider: GO:0001076 consider: GO:0006366 [Term] id: GO:0016254 name: preassembly of GPI anchor in ER membrane namespace: biological_process def: "The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane." [ISBN:0879695595] subset: gosubset_prok synonym: "preassembly of GPI anchor in endoplasmic reticulum membrane" EXACT [] xref: Reactome:1253312 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1280250 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1299109 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1326828 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1352929 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1373134 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1393150 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1417634 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1450734 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1471179 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1483171 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1496874 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1514267 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1521118 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1526884 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1532613 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:1536061 "Synthesis of glycosylphosphatidylinositol (GPI)" xref: Reactome:162710 "Synthesis of glycosylphosphatidylinositol (GPI)" is_a: GO:0006650 ! glycerophospholipid metabolic process relationship: part_of GO:0006506 ! GPI anchor biosynthetic process [Term] id: GO:0016255 name: attachment of GPI anchor to protein namespace: biological_process def: "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595] subset: gosubset_prok xref: Reactome:1253318 "Attachment of GPI anchor to uPAR" xref: Reactome:1280256 "Attachment of GPI anchor to uPAR" xref: Reactome:1299115 "Attachment of GPI anchor to uPAR" xref: Reactome:1326834 "Attachment of GPI anchor to uPAR" xref: Reactome:1352931 "Attachment of GPI anchor to uPAR" xref: Reactome:1450736 "Attachment of GPI anchor to uPAR" xref: Reactome:162791 "Attachment of GPI anchor to uPAR" is_a: GO:0006464 ! protein modification process relationship: part_of GO:0006506 ! GPI anchor biosynthetic process [Term] id: GO:0016256 name: N-glycan processing to lysosome namespace: biological_process def: "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome." [ISBN:0879695595] is_a: GO:0006491 ! N-glycan processing relationship: part_of GO:0006622 ! protein targeting to lysosome [Term] id: GO:0016257 name: N-glycan processing to secreted and cell-surface N-glycans namespace: biological_process def: "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus." [ISBN:0879695595] subset: gosubset_prok is_a: GO:0006491 ! N-glycan processing [Term] id: GO:0016258 name: N-glycan diversification namespace: biological_process def: "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases." [ISBN:0879695595] subset: gosubset_prok is_a: GO:0006491 ! N-glycan processing [Term] id: GO:0016259 name: selenocysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "selenocysteine metabolism" EXACT [] is_a: GO:0001887 ! selenium compound metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0016260 name: selenocysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "selenocysteine anabolism" EXACT [] synonym: "selenocysteine biosynthesis" EXACT [] synonym: "selenocysteine formation" EXACT [] synonym: "selenocysteine synthesis" EXACT [] is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0016259 ! selenocysteine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0016261 name: selenocysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "selenocysteine breakdown" EXACT [] synonym: "selenocysteine catabolism" EXACT [] synonym: "selenocysteine degradation" EXACT [] is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0016259 ! selenocysteine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process [Term] id: GO:0016262 name: protein N-acetylglucosaminyltransferase activity namespace: molecular_function alt_id: GO:0016253 def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94] synonym: "N-GlcNAc transferase activity" EXACT [EC:2.4.1.94] synonym: "O-GlcNAc transferase activity" EXACT [] synonym: "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity" EXACT [] synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity" EXACT [] synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT [] xref: EC:2.4.1.94 xref: MetaCyc:2.4.1.94-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0016263 name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma] synonym: "Core 1 GalT" RELATED [] synonym: "UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] synonym: "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] synonym: "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity" EXACT [EC:2.4.1.122] xref: EC:2.4.1.122 xref: MetaCyc:2.4.1.122-RXN is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity [Term] id: GO:0016264 name: gap junction assembly namespace: biological_process def: "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jid, ISBN:0716731363] xref: Reactome:1253453 "Gap junction assembly" xref: Reactome:1280392 "Gap junction assembly" xref: Reactome:1299228 "Gap junction assembly" xref: Reactome:1326969 "Gap junction assembly" xref: Reactome:1353064 "Gap junction assembly" xref: Reactome:1373255 "Gap junction assembly" xref: Reactome:1393272 "Gap junction assembly" xref: Reactome:1417765 "Gap junction assembly" xref: Reactome:1450866 "Gap junction assembly" xref: Reactome:190861 "Gap junction assembly" is_a: GO:0007043 ! cell-cell junction assembly [Term] id: GO:0016265 name: death namespace: biological_process def: "A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, ISBN:0877797099] comment: See also the biological process term 'apoptosis ; GO:0006915'. subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Death is_a: GO:0008150 ! biological_process [Term] id: GO:0016266 name: O-glycan processing namespace: biological_process def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form a core O-glycan structure." [GOC:mah, PMID:10580130] subset: gosubset_prok is_a: GO:0006493 ! protein O-linked glycosylation [Term] id: GO:0016267 name: O-glycan processing, core 1 namespace: biological_process def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-1->3-GalNAc." [GOC:mah, PMID:10580130] subset: gosubset_prok is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016268 name: O-glycan processing, core 2 namespace: biological_process def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-1->6(Gal-beta-1->3)-GalNAc." [GOC:mah, PMID:10580130] subset: gosubset_prok is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016269 name: O-glycan processing, core 3 namespace: biological_process def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-1->3-GalNAc." [GOC:mah, PMID:10580130] subset: gosubset_prok is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016270 name: O-glycan processing, core 4 namespace: biological_process def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-1->6(GlcNAc-beta-1->3)-GalNAc." [GOC:mah, PMID:10580130] subset: gosubset_prok is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016271 name: tissue death namespace: biological_process def: "A permanent cessation of all vital functions of a tissue." [GOC:dph] is_a: GO:0016265 ! death [Term] id: GO:0016272 name: prefoldin complex namespace: cellular_component def: "A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229] subset: gosubset_prok synonym: "GIM complex" NARROW [] xref: Wikipedia:Prefoldin is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0016273 name: arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah] xref: EC:2.1.1.- is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016274 name: protein-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [EC:2.1.1.125, EC:2.1.1.126, GOC:mah, PMID:12351636] synonym: "PRMT activity" EXACT [] xref: EC:2.1.1.- xref: Reactome:24476 "protein-arginine N-methyltransferase activity" is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0016273 ! arginine N-methyltransferase activity [Term] id: GO:0016275 name: [cytochrome c]-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [EC:2.1.1.124, GOC:ma] synonym: "cytochrome c-arginine N-methyltransferase activity" EXACT [EC:2.1.1.124] synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea" RELATED [EC:2.1.1.124] synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124] xref: EC:2.1.1.124 xref: MetaCyc:2.1.1.124-RXN is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0016277 name: [myelin basic protein]-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [EC:2.1.1.126] synonym: "myelin basic protein methylase activity" EXACT [EC:2.1.1.126] synonym: "myelin basic protein methylase I" RELATED [EC:2.1.1.126] synonym: "myelin basic protein-arginine N-methyltransferase activity" EXACT [EC:2.1.1.126] synonym: "protein methylase I activity" BROAD [EC:2.1.1.126] synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.126] synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.126] xref: EC:2.1.1.126 xref: MetaCyc:2.1.1.126-RXN is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0016278 name: lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016279 name: protein-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0016278 ! lysine N-methyltransferase activity [Term] id: GO:0016281 name: eukaryotic translation initiation factor 4F complex namespace: cellular_component def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:8449919] synonym: "eIF-4F" EXACT [] synonym: "eukaryotic translation initiation factor 4 complex" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0016282 name: eukaryotic 43S preinitiation complex namespace: cellular_component def: "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] synonym: "eukaryotic 43S pre-initiation complex" EXACT [] is_a: GO:0070993 ! translation preinitiation complex [Term] id: GO:0016284 name: alanine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. subset: gosubset_prok xref: EC:3.4.11.- is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0016285 name: cytosol alanyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14] comment: This term was made obsolete because it represents a gene product and refers to cellular component information. subset: gosubset_prok synonym: "aminopolypeptidase activity" EXACT [EC:3.4.11.14] synonym: "arylamidase activity" NARROW [EC:3.4.11.14] synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14] synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14] synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14] synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14] synonym: "soluble alanyl aminopeptidase activity" EXACT [EC:3.4.11.14] synonym: "thiol-activated aminopeptidase activity" EXACT [EC:3.4.11.14] xref: EC:3.4.11.14 xref: MetaCyc:3.4.11.14-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0016286 name: small conductance calcium-activated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] synonym: "SK calcium-activated potassium channel activity " EXACT [] synonym: "SK KCa channels" EXACT [] synonym: "small conductance KCa channels " EXACT [] is_a: GO:0015269 ! calcium-activated potassium channel activity [Term] id: GO:0016287 name: glycerone-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA." [EC:2.3.1.42, RHEA:17660] synonym: "acyl-CoA:glycerone-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.42] synonym: "dihydroxyacetone phosphate acyltransferase activity" EXACT [EC:2.3.1.42] xref: EC:2.3.1.42 xref: KEGG:R01013 xref: MetaCyc:2.3.1.42-RXN xref: Reactome:24512 "glycerone-phosphate O-acyltransferase activity" xref: RHEA:17660 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0016289 name: CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group." [GOC:ai] subset: gosubset_prok xref: EC:3.1.2.- xref: Reactome:10046 "CoA hydrolase activity" is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0016290 name: palmitoyl-CoA hydrolase activity namespace: molecular_function alt_id: GO:0016293 def: "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [EC:3.1.2.2] subset: gosubset_prok synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2] synonym: "long-chain fatty-acyl-CoA hydrolase activity" EXACT [] synonym: "palmitoyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl-CoA deacylase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2] synonym: "palmityl-CoA deacylase activity" EXACT [EC:3.1.2.2] xref: EC:3.1.2.2 xref: MetaCyc:PALMITOYL-COA-HYDROLASE-RXN xref: MetaCyc:PWY-5148 is_a: GO:0016291 ! acyl-CoA thioesterase activity [Term] id: GO:0016291 name: acyl-CoA thioesterase activity namespace: molecular_function alt_id: GO:0008778 alt_id: GO:0016292 def: "Catalysis of the reaction: acyl-CoA + H2O = corresponding fatty acid + CoA." [PMID:14660652] subset: gosubset_prok synonym: "acyl-CoA thioesterase I activity" NARROW [] synonym: "acyl-CoA thioesterase II activity" NARROW [] synonym: "acyl-CoA thiolesterase activity" EXACT [] xref: EC:3.1.2.- is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0016295 name: myristoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727] synonym: "myristoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "myristoyl-ACP hydrolase activity" EXACT [] synonym: "tetradecanoyl-[acyl-carrier-protein] hydrolase activity" EXACT [] synonym: "tetradecanoyl-ACP hydrolase activity" EXACT [] xref: EC:3.1.2.14 xref: KEGG:R08159 xref: MetaCyc:RXN-10727 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0016296 name: palmitoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549] synonym: "palmitoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "palmitoyl-ACP hydrolase activity" EXACT [] xref: EC:3.1.2.14 xref: KEGG:R08162 xref: MetaCyc:RXN-9549 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0016297 name: acyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function alt_id: GO:0010281 def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid." [EC:3.1.2.14, MetaCyc:RXN-7902] subset: gosubset_prok synonym: "acyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "acyl-ACP hydrolase activity" EXACT [] synonym: "acyl-ACP thioesterase activity" EXACT [] synonym: "acyl-ACP-hydrolase activity" EXACT [EC:3.1.2.14] synonym: "acyl-acyl carrier protein hydrolase activity" EXACT [EC:3.1.2.14] synonym: "acyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.14] synonym: "S-acyl fatty acid synthase thioesterase activity" EXACT [EC:3.1.2.14] xref: EC:3.1.2.14 xref: MetaCyc:RXN-7902 is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0016298 name: lipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] subset: gosubset_prok xref: EC:3.1.1.- xref: Reactome:1913 "lipase activity" is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0016299 name: regulator of G-protein signaling activity namespace: molecular_function def: "OBSOLETE. Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [GOC:curators] comment: This term was made obsolete because it refers to a combination of a function and a process. synonym: "regulator of G protein signaling activity" EXACT [] synonym: "regulator of G protein signalling activity" EXACT [] synonym: "regulator of G-protein signalling activity" EXACT [] synonym: "RGS" EXACT [] is_obsolete: true consider: GO:0005095 consider: GO:0034260 consider: GO:0045744 [Term] id: GO:0016300 name: tRNA (uracil) methyltransferase activity namespace: molecular_function alt_id: GO:0016431 def: "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). subset: gosubset_prok synonym: "tRNA (uridine) methyltransferase activity" EXACT [] xref: EC:2.1.1.- is_a: GO:0008175 ! tRNA methyltransferase activity [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_plant subset: gosubset_prok synonym: "phosphokinase activity" EXACT [] xref: Reactome:1423 "kinase activity" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016303 name: 1-phosphatidylinositol-3-kinase activity namespace: molecular_function alt_id: GO:0004429 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12712] synonym: "1-phosphatidylinositol 3-kinase activity" EXACT [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity" EXACT [EC:2.7.1.137] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class III" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "PI3-kinase activity" EXACT [EC:2.7.1.137] synonym: "PI3K" EXACT [] synonym: "PtdIns-3-kinase activity" EXACT [EC:2.7.1.137] synonym: "type I phosphatidylinositol kinase activity" NARROW [EC:2.7.1.137] synonym: "type III phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.137] synonym: "Vps34p" RELATED [EC:2.7.1.137] xref: EC:2.7.1.137 xref: KEGG:R03362 xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN xref: RHEA:12712 is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity [Term] id: GO:0016304 name: phosphatidylinositol 3-kinase activity, class I namespace: molecular_function def: "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity." [PMID:9759495] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0016303 replaced_by: GO:0035005 replaced_by: GO:0046934 [Term] id: GO:0016305 name: phosphatidylinositol 3-kinase activity, class II namespace: molecular_function def: "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine." [PMID:9759495] comment: This term was made obsolete because it represents a class of gene products. synonym: "PI3KC2" EXACT [] is_obsolete: true consider: GO:0016303 consider: GO:0035005 consider: GO:0046934 [Term] id: GO:0016306 name: phosphatidylinositol 3-kinase activity, class III namespace: molecular_function def: "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol." [PMID:9759495] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0016303 [Term] id: GO:0016307 name: phosphatidylinositol phosphate kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495] subset: gosubset_prok xref: EC:2.7.1.- is_a: GO:0001727 ! lipid kinase activity is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0016308 name: 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: molecular_function alt_id: GO:0004431 alt_id: GO:0045215 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14428] subset: gosubset_prok synonym: "1-phosphatidylinositol-4-phosphate kinase activity" BROAD [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.68] synonym: "diphosphoinositide kinase activity" BROAD [EC:2.7.1.68] synonym: "phosphatidylinositol 4-phosphate kinase activity" BROAD [EC:2.7.1.68] synonym: "phosphatidylinositol-4-phosphate 5-kinase activity" EXACT [EC:2.7.1.68] synonym: "PIP kinase activity" BROAD [EC:2.7.1.68] synonym: "PIP5K" EXACT [] synonym: "PtdIns(4)P-5-kinase activity" EXACT [EC:2.7.1.68] synonym: "type I PIP kinase activity" NARROW [EC:2.7.1.68] xref: EC:2.7.1.68 xref: KEGG:R03469 xref: MetaCyc:2.7.1.68-RXN xref: RHEA:14428 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0016309 name: 1-phosphatidylinositol-5-phosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149] synonym: "1-phosphatidylinositol-5-phosphate kinase" BROAD [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" EXACT [EC:2.7.1.149] synonym: "PIP4K" EXACT [] synonym: "type II PIP kinase activity" NARROW [EC:2.7.1.149] xref: EC:2.7.1.149 xref: MetaCyc:2.7.1.149-RXN is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Wikipedia:Phosphorylation is_a: GO:0006796 ! phosphate metabolic process [Term] id: GO:0016311 name: dephosphorylation namespace: biological_process def: "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Wikipedia:Dephosphorylation is_a: GO:0006796 ! phosphate metabolic process [Term] id: GO:0016312 name: inositol bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the removal of one of the two phosphate groups of an inositol bisphosphate." [GOC:hb] xref: EC:3.1.3.- is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0016313 name: inositol-1,4,5-trisphosphate phosphatase namespace: molecular_function def: "OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate." [GOC:hb] comment: This term was made obsolete because it is a redundant grouping term with only one child. is_obsolete: true consider: GO:0046030 [Term] id: GO:0016314 name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67] synonym: "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] synonym: "MMAC1" RELATED [EC:3.1.3.67] synonym: "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] xref: EC:3.1.3.67 xref: MetaCyc:3.1.3.67-RXN xref: Reactome:24758 "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity" is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity is_a: GO:0042577 ! lipid phosphatase activity [Term] id: GO:0016316 name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity namespace: molecular_function alt_id: GO:0004440 def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb] synonym: "1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66] synonym: "D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66] synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] synonym: "inositol-1,4,-bisphosphate 4-phosphatase activity" EXACT [] synonym: "inositol-3,4-bisphosphate 4-phosphatase activity" EXACT [] xref: EC:3.1.3.66 xref: MetaCyc:3.1.3.66-RXN is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity is_a: GO:0042577 ! lipid phosphatase activity [Term] id: GO:0016318 name: ommatidial rotation namespace: biological_process def: "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity [Term] id: GO:0016319 name: mushroom body development namespace: biological_process def: "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0016320 name: endoplasmic reticulum membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid] synonym: "ER membrane fusion" EXACT [] is_a: GO:0048284 ! organelle fusion is_a: GO:0090174 ! organelle membrane fusion [Term] id: GO:0016321 name: female meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0016322 name: neuron remodeling namespace: biological_process def: "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] synonym: "axon pruning" NARROW [GOC:sart, PMID:18267091] synonym: "neuronal remodeling" EXACT [] is_a: GO:0042551 ! neuron maturation [Term] id: GO:0016323 name: basolateral plasma membrane namespace: cellular_component def: "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0016324 name: apical plasma membrane namespace: cellular_component def: "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0045177 ! apical part of cell [Term] id: GO:0016325 name: oocyte microtubule cytoskeleton organization namespace: biological_process alt_id: GO:0048130 def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] synonym: "oocyte microtubule cytoskeleton organisation" EXACT [GOC:curators] is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007308 ! oocyte construction [Term] id: GO:0016326 name: kinesin motor activity namespace: molecular_function def: "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules." [GOC:hb] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003777 [Term] id: GO:0016327 name: apicolateral plasma membrane namespace: cellular_component def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0016328 name: lateral plasma membrane namespace: cellular_component def: "The membranes on the sides of epithelial cells which lie at the interface of adjacent cells." [GOC:hb] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0016329 name: apoptosis regulator activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis." [GOC:jl] comment: This term was made obsolete because it represents involvement in a biological process. is_obsolete: true replaced_by: GO:0042981 [Term] id: GO:0016330 name: second mitotic wave involved in compound eye morphogenesis namespace: biological_process def: "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] synonym: "second mitotic wave during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0000278 ! mitotic cell cycle relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0016331 name: morphogenesis of embryonic epithelium namespace: biological_process def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0016332 name: establishment or maintenance of polarity of embryonic epithelium namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0016333 name: morphogenesis of follicular epithelium namespace: biological_process def: "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0016334 name: establishment or maintenance of polarity of follicular epithelium namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium [Term] id: GO:0016335 name: morphogenesis of larval imaginal disc epithelium namespace: biological_process def: "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0002168 ! instar larval development relationship: part_of GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0016336 name: establishment or maintenance of polarity of larval imaginal disc epithelium namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0016335 ! morphogenesis of larval imaginal disc epithelium [Term] id: GO:0016337 name: cell-cell adhesion namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules." [GOC:hb] subset: gosubset_prok is_a: GO:0007155 ! cell adhesion [Term] id: GO:0016338 name: calcium-independent cell-cell adhesion namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-independent cell adhesion molecule activity" RELATED [] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0016339 name: calcium-dependent cell-cell adhesion namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-dependent cell adhesion molecule activity" RELATED [] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0016340 name: calcium-dependent cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] is_a: GO:0007160 ! cell-matrix adhesion [Term] id: GO:0016341 name: other collagen namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. is_obsolete: true replaced_by: GO:0005581 [Term] id: GO:0016342 name: catenin complex namespace: cellular_component def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] is_a: GO:0019897 ! extrinsic to plasma membrane is_a: GO:0043234 ! protein complex [Term] id: GO:0016343 name: cytoskeletal anchoring activity namespace: molecular_function def: "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0007016 [Term] id: GO:0016344 name: meiotic chromosome movement towards spindle pole namespace: biological_process def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai] synonym: "chromosome migration to spindle pole during meiosis" EXACT [] synonym: "chromosome movement towards spindle pole during meiosis" EXACT [] synonym: "meiotic chromosome movement" BROAD [] synonym: "meiotic chromosome movement to spindle pole" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051305 ! chromosome movement towards spindle pole relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0016345 name: female meiotic chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai] synonym: "chromosome movement towards spindle pole during female meiosis" EXACT [] synonym: "female meiotic chromosome movement" BROAD [] synonym: "female meiotic chromosome movement to spindle pole" EXACT [] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole relationship: part_of GO:0016321 ! female meiosis chromosome segregation [Term] id: GO:0016346 name: male meiotic chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai] synonym: "chromosome movement towards spindle pole during male meiosis" EXACT [] synonym: "male meiotic chromosome movement" BROAD [] synonym: "male meiotic chromosome movement to spindle pole" EXACT [] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole relationship: part_of GO:0007060 ! male meiosis chromosome segregation [Term] id: GO:0016347 name: calcium-independent cell adhesion molecule activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0005515 consider: GO:0007161 consider: GO:0016021 consider: GO:0016338 [Term] id: GO:0016348 name: imaginal disc-derived leg joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0035111 ! leg joint morphogenesis relationship: part_of GO:0007480 ! imaginal disc-derived leg morphogenesis [Term] id: GO:0016351 name: drug susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0042493 [Term] id: GO:0016352 name: insecticide susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0017085 [Term] id: GO:0016353 name: carbamate susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046681 [Term] id: GO:0016354 name: cyclodiene susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046682 [Term] id: GO:0016355 name: DDT susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046680 [Term] id: GO:0016356 name: organophosphorus susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046683 [Term] id: GO:0016357 name: pyrethroid susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046684 [Term] id: GO:0016358 name: dendrite development namespace: biological_process def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0031175 ! neuron projection development is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0016360 name: sensory organ precursor cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] synonym: "sense organ precursor cell fate determination" EXACT [GOC:dph] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0008052 ! sensory organ boundary specification [Term] id: GO:0016361 name: activin receptor activity, type I namespace: molecular_function def: "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651] synonym: "type I activin receptor activity" EXACT [] is_a: GO:0017002 ! activin receptor activity [Term] id: GO:0016362 name: activin receptor activity, type II namespace: molecular_function def: "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor." [GOC:mah, PMID:8622651] synonym: "type II activin receptor activity" EXACT [] xref: Reactome:24823 "activin receptor activity, type II" is_a: GO:0017002 ! activin receptor activity [Term] id: GO:0016363 name: nuclear matrix namespace: cellular_component def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] synonym: "nucleoskeleton " EXACT [] xref: Wikipedia:Nuclear_matrix is_a: GO:0044428 ! nuclear part relationship: part_of GO:0034399 ! nuclear periphery [Term] id: GO:0016401 name: palmitoyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide." [GOC:jsg] xref: EC:1.3.3.- is_a: GO:0003997 ! acyl-CoA oxidase activity [Term] id: GO:0016402 name: pristanoyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide." [GOC:jsg] xref: EC:1.3.3.- xref: Reactome:25174 "pristanoyl-CoA oxidase activity" is_a: GO:0003997 ! acyl-CoA oxidase activity [Term] id: GO:0016403 name: dimethylargininase activity namespace: molecular_function def: "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18] subset: gosubset_prok synonym: "dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] synonym: "N(G),N(G)-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] synonym: "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity" EXACT [EC:3.5.3.18] synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] xref: EC:3.5.3.18 xref: MetaCyc:DIMETHYLARGININASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0016404 name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141] synonym: "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] synonym: "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] synonym: "15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "15-hydroxyprostanoic dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "15-OH-PGDH" RELATED [EC:1.1.1.141] synonym: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)" EXACT [EC:1.1.1.141] synonym: "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "prostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] xref: EC:1.1.1.141 xref: MetaCyc:1.1.1.141-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016405 name: CoA-ligase activity namespace: molecular_function def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai] subset: gosubset_prok xref: Reactome:10971 "CoA-ligase activity" is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0016406 name: carnitine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0016407 name: acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai] subset: gosubset_prok synonym: "acetylase activity" EXACT [] xref: EC:2.3.1.- xref: Reactome:1621 "acetyltransferase activity" is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0016408 name: C-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0016409 name: palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: Reactome:2202 "palmitoyltransferase activity" is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0016410 name: N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: Reactome:1095 "N-acyltransferase activity" is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0016411 name: acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0016412 name: serine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0016413 name: O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0016414 name: O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016415 ! octanoyltransferase activity [Term] id: GO:0016415 name: octanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0016416 name: O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016409 ! palmitoyltransferase activity [Term] id: GO:0016417 name: S-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0016418 name: S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016417 ! S-acyltransferase activity [Term] id: GO:0016419 name: S-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0016417 ! S-acyltransferase activity is_a: GO:0016420 ! malonyltransferase activity [Term] id: GO:0016420 name: malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0016421 name: CoA carboxylase activity namespace: molecular_function def: "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah] subset: gosubset_prok xref: EC:6.4.1.- is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0016422 name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62] synonym: "messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity" EXACT [EC:2.1.1.62] synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.62] synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.62] xref: EC:2.1.1.62 xref: MetaCyc:2.1.1.62-RXN is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0016423 name: tRNA (guanine) methyltransferase activity namespace: molecular_function alt_id: GO:0016424 def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in a tRNA molecule." [GOC:mah] subset: gosubset_prok synonym: "tRNA (guanosine) methyltransferase activity" EXACT [] xref: EC:2.1.1.- is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016426 name: tRNA (adenine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in a tRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016427 name: tRNA (cytosine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in a tRNA molecule." [GOC:mah] xref: EC:2.1.1.- is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016428 name: tRNA (cytosine-5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29] synonym: "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.29] synonym: "transfer ribonucleate cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] synonym: "transfer RNA cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] xref: EC:2.1.1.29 xref: MetaCyc:TRNA-CYTOSINE-5--METHYLTRANSFERASE-RXN is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity [Term] id: GO:0016429 name: tRNA (adenine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36] subset: gosubset_prok synonym: "1-methyladenine transfer RNA methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "adenine-1-methylase activity" EXACT [EC:2.1.1.36] synonym: "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "transfer ribonucleate adenine 1-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "transfer RNA (adenine-1) methyltransferase activity" EXACT [EC:2.1.1.36] xref: EC:2.1.1.36 xref: MetaCyc:TRNA-ADENINE-N1--METHYLTRANSFERASE-RXN is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0016430 name: tRNA (adenine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55] synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.55] synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.55] xref: EC:2.1.1.55 xref: MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0016432 name: tRNA-uridine aminocarboxypropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25] synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.25] xref: EC:2.5.1.25 xref: MetaCyc:2.5.1.25-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0016433 name: rRNA (adenine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016434 name: rRNA (cytosine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016435 name: rRNA (guanine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016436 name: rRNA (uridine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a uridine residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016437 name: tRNA cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.21] synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.21] synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" EXACT [EC:2.7.7.21] synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "CTP:tRNA cytidylyltransferase activity" EXACT [] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.21] synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.21] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.21] synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.21] xref: EC:2.7.7.21 xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0016438 name: tRNA-queuosine beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine." [EC:2.4.1.110] synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.110] xref: EC:2.4.1.110 xref: MetaCyc:2.4.1.110-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0016441 name: posttranscriptional gene silencing namespace: biological_process def: "The inactivation of gene expression by a posttranscriptional mechanism." [GOC:mah, PMID:15020054] synonym: "cosuppression" RELATED [] synonym: "PTGS" EXACT [] synonym: "quelling" EXACT [] xref: Wikipedia:Post_transcriptional_gene_silencing is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0016458 ! gene silencing is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0016442 name: RNA-induced silencing complex namespace: cellular_component def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] synonym: "RISC complex" EXACT [] xref: Wikipedia:RNA-induced_silencing_complex is_a: GO:0031332 ! RNAi effector complex [Term] id: GO:0016443 name: bidentate ribonuclease III activity namespace: molecular_function def: "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644] synonym: "bidentate RNase III activity" EXACT [] xref: EC:3.1.26.- is_a: GO:0004525 ! ribonuclease III activity [Term] id: GO:0016444 name: somatic cell DNA recombination namespace: biological_process def: "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma] is_a: GO:0006310 ! DNA recombination [Term] id: GO:0016445 name: somatic diversification of immunoglobulins namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic diversification of antibodies" EXACT [] is_a: GO:0002200 ! somatic diversification of immune receptors relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0016446 name: somatic hypermutation of immunoglobulin genes namespace: biological_process def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007] synonym: "somatic hypermutation of antibody genes" EXACT [] is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016447 name: somatic recombination of immunoglobulin gene segments namespace: biological_process def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic recombination of antibody gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016453 name: C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0016454 name: C-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0016408 ! C-acyltransferase activity is_a: GO:0016409 ! palmitoyltransferase activity [Term] id: GO:0016456 name: X chromosome located dosage compensation complex, transcription activating namespace: cellular_component def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mtg_sensu] synonym: "dosage compensation complex" BROAD [] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0046536 ! dosage compensation complex relationship: part_of GO:0000805 ! X chromosome [Term] id: GO:0016457 name: dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl] synonym: "dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome" RELATED [GOC:dph, GOC:tb] is_a: GO:0042714 ! dosage compensation complex assembly is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0009047 ! dosage compensation, by hyperactivation of X chromosome [Term] id: GO:0016458 name: gene silencing namespace: biological_process def: "Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jid, GOC:tb] comment: Note that this process is the opposite of long-term maintenance of gene activation. subset: goslim_pir synonym: "long-term maintenance of gene inactivation" RELATED [] xref: Wikipedia:Gene_silencing is_a: GO:0009987 ! cellular process is_a: GO:0010629 ! negative regulation of gene expression [Term] id: GO:0016459 name: myosin complex namespace: cellular_component def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0016460 name: myosin II complex namespace: cellular_component def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] synonym: "conventional myosin" RELATED [] is_a: GO:0016459 ! myosin complex [Term] id: GO:0016461 name: unconventional myosin complex namespace: cellular_component alt_id: GO:0005860 def: "A portmanteau term for myosins other than myosin II." [GOC:ma] comment: Note that this term is retained because it is widely used by biologists. synonym: "non-muscle myosin" RELATED [] is_a: GO:0016459 ! myosin complex [Term] id: GO:0016462 name: pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators] subset: gosubset_prok xref: EC:3.6.1.- is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0016463 name: zinc-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) = ADP + phosphate + Zn2+(out)." [EC:3.6.3.5] subset: gosubset_prok synonym: "AtHMA4" RELATED [EC:3.6.3.5] synonym: "ATP phosphohydrolase (Zn2+-exporting)" EXACT [EC:3.6.3.5] synonym: "P(1B)-type ATPase activity" NARROW [EC:3.6.3.5] synonym: "P1B-type ATPase activity" EXACT [EC:3.6.3.5] synonym: "zinc exporting ATPase activity" EXACT [] synonym: "zinc-translocating P-type ATPase activity" BROAD [EC:3.6.3.5] synonym: "Zn(2+)-exporting ATPase activity" EXACT [EC:3.6.3.5] synonym: "Zn(II)-translocating P-type ATPase activity" EXACT [EC:3.6.3.5] synonym: "Zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5] synonym: "zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5] xref: EC:3.6.3.5 xref: MetaCyc:3.6.3.5-RXN is_a: GO:0005385 ! zinc ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0016464 name: chloroplast protein-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:3.6.3.52] synonym: "ATP phosphohydrolase (chloroplast protein-importing)" EXACT [EC:3.6.3.52] synonym: "chloroplast protein ABC transporter" NARROW [] xref: EC:3.6.3.52 xref: MetaCyc:3.6.3.52-RXN is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity [Term] id: GO:0016465 name: chaperonin ATPase complex namespace: cellular_component def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0016466 name: hydrogen-translocating A-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae." [TC:3.A.2.3.1] comment: This term was made obsolete because it represents a gene product. synonym: "proton-translocating A-type ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0046961 [Term] id: GO:0016467 name: hydrogen-translocating F-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.1, TC:3.A.2.1.3] comment: This term was made obsolete because it represents a gene product. synonym: "ATP synthase" BROAD [] synonym: "F1-ATPase activity" EXACT [] synonym: "proton-translocating F-type ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0046933 replaced_by: GO:0046961 [Term] id: GO:0016468 name: sodium-translocating F-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.2] comment: This term was made obsolete because it represents a gene product. synonym: "ATP synthase" BROAD [] is_obsolete: true replaced_by: GO:0046932 replaced_by: GO:0046962 [Term] id: GO:0016469 name: proton-transporting two-sector ATPase complex namespace: cellular_component def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] subset: goslim_pir subset: gosubset_prok synonym: "hydrogen-transporting two-sector ATPase complex" EXACT [] synonym: "vacuolar hydrogen-transporting ATPase" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part [Term] id: GO:0016471 name: vacuolar proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'. subset: gosubset_prok synonym: "vacuolar hydrogen-translocating V-type ATPase complex" EXACT [] is_a: GO:0033176 ! proton-transporting V-type ATPase complex is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0016472 name: sodium ion-transporting two-sector ATPase complex namespace: cellular_component def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431] subset: goslim_pir synonym: "sodium-transporting two-sector ATPase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0016021 ! integral to membrane [Term] id: GO:0016473 name: sodium ion-transporting F-type ATPase complex namespace: cellular_component def: "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431] synonym: "sodium-translocating F-type ATPase complex" EXACT [] is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex [Term] id: GO:0016474 name: sodium ion-transporting V-type ATPase complex namespace: cellular_component def: "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565] synonym: "sodium-translocating V-type ATPase complex" EXACT [] is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex [Term] id: GO:0016475 name: detection of nuclear:cytoplasmic ratio namespace: biological_process def: "The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell." [GOC:jl] synonym: "interpretation of nuclear:cytoplasmic ratio" EXACT [] synonym: "sensing of nuclear:cytoplasmic ratio" EXACT [] is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0016049 ! cell growth [Term] id: GO:0016476 name: regulation of embryonic cell shape namespace: biological_process def: "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] synonym: "shape changes of embryonic cells" RELATED [GOC:dph, GOC:tb] is_a: GO:0008360 ! regulation of cell shape is_a: GO:0045995 ! regulation of embryonic development [Term] id: GO:0016477 name: cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another, often during the development of a multicellular organism or multicellular structure." [GOC:ems, GOC:pf] xref: Wikipedia:Cell_migration is_a: GO:0048870 ! cell motility [Term] id: GO:0016479 name: negative regulation of transcription from RNA polymerase I promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "down-regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "downregulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "inhibition of transcription from RNA polymerase I promoter" NARROW [] synonym: "negative regulation of transcription from Pol I promoter" EXACT [] is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent relationship: negatively_regulates GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0016480 name: negative regulation of transcription from RNA polymerase III promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "down-regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "downregulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "inhibition of transcription from RNA polymerase III promoter" NARROW [] synonym: "negative regulation of transcription from Pol III promoter" EXACT [] is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent relationship: negatively_regulates GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0016482 name: cytoplasmic transport namespace: biological_process def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell." [GOC:ai] synonym: "cytoplasmic streaming" NARROW [] is_a: GO:0046907 ! intracellular transport [Term] id: GO:0016483 name: tryptophan hydroxylase activator activity namespace: molecular_function def: "Increases the activity of the enzyme tryptophase hydroxylase." [GOC:ai] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0016484 name: proprotein convertase 2 activator activity namespace: molecular_function def: "OBSOLETE. Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. is_obsolete: true consider: GO:0016504 [Term] id: GO:0016485 name: protein processing namespace: biological_process def: "Any protein maturation process achieved by the cleavage of peptide bonds." [GOC:curators, GOC:jl, GOC:jsg] subset: gosubset_prok is_a: GO:0051604 ! protein maturation [Term] id: GO:0016486 name: peptide hormone processing namespace: biological_process def: "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah] xref: Reactome:1253596 "Peptide hormone biosynthesis" xref: Reactome:1280527 "Peptide hormone biosynthesis" xref: Reactome:1299358 "Peptide hormone biosynthesis" xref: Reactome:1327113 "Peptide hormone biosynthesis" xref: Reactome:1353208 "Peptide hormone biosynthesis" xref: Reactome:1373384 "Peptide hormone biosynthesis" xref: Reactome:1393409 "Peptide hormone biosynthesis" xref: Reactome:1417904 "Peptide hormone biosynthesis" xref: Reactome:1450994 "Peptide hormone biosynthesis" xref: Reactome:209952 "Peptide hormone biosynthesis" is_a: GO:0042445 ! hormone metabolic process is_a: GO:0051605 ! protein maturation by peptide bond cleavage [Term] id: GO:0016487 name: farnesol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] subset: gosubset_prok synonym: "farnesol metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0016488 name: farnesol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] subset: gosubset_prok synonym: "farnesol breakdown" EXACT [] synonym: "farnesol catabolism" EXACT [] synonym: "farnesol degradation" EXACT [] is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0016487 ! farnesol metabolic process is_a: GO:0034310 ! primary alcohol catabolic process [Term] id: GO:0016490 name: structural constituent of peritrophic membrane namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "structural constituent of peritrophic matrix" RELATED [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term. subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1 xref: Reactome:95 "oxidoreductase activity" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016492 name: neurotensin receptor activity, G-protein coupled namespace: molecular_function def: "Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [PMID:10390649] synonym: "G protein coupled neurotensin receptor activity" EXACT [] synonym: "G-protein coupled neurotensin receptor activity" EXACT [] synonym: "G-protein-coupled neurotensin receptor activity" EXACT [] synonym: "neurotensin receptor activity, G protein coupled" EXACT [] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0016493 name: C-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-C chemokine to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [PMID:8662823] is_a: GO:0004950 ! chemokine receptor activity is_a: GO:0019957 ! C-C chemokine binding [Term] id: GO:0016494 name: C-X-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-X-C chemokine to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [PMID:8662823] is_a: GO:0004950 ! chemokine receptor activity is_a: GO:0019958 ! C-X-C chemokine binding [Term] id: GO:0016495 name: C-X3-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-X3-C chemokine to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph] is_a: GO:0004950 ! chemokine receptor activity is_a: GO:0019960 ! C-X3-C chemokine binding [Term] id: GO:0016496 name: substance P receptor activity namespace: molecular_function def: "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004995 ! tachykinin receptor activity [Term] id: GO:0016497 name: substance K receptor activity namespace: molecular_function def: "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "neurokinin A receptor activity" EXACT [] synonym: "neuromedin L receptor activity" EXACT [] is_a: GO:0004995 ! tachykinin receptor activity [Term] id: GO:0016498 name: neuromedin K receptor activity namespace: molecular_function def: "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "neurokinin B receptor activity" EXACT [] is_a: GO:0004995 ! tachykinin receptor activity [Term] id: GO:0016499 name: orexin receptor activity namespace: molecular_function def: "Combining with orexin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0016500 name: protein-hormone receptor activity namespace: molecular_function def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0016501 name: prostacyclin receptor activity namespace: molecular_function alt_id: GO:0004959 def: "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGI receptor activity" RELATED [] synonym: "PGI(2) receptor activity" EXACT [] synonym: "prostaglandin I receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0016502 name: nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0016503 name: pheromone receptor activity namespace: molecular_function def: "Combining with a pheromone to initiate a change in cell activity." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0016504 name: peptidase activator activity namespace: molecular_function def: "Increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:ai] subset: gosubset_prok synonym: "protease activator activity" EXACT [GOC:mah] xref: Reactome:11526 "peptidase activator activity" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0061134 ! peptidase regulator activity [Term] id: GO:0016505 name: apoptotic protease activator activity namespace: molecular_function def: "Increases the activity of a peptidase that is involved in the activation of apoptosis." [GOC:mah] is_a: GO:0016504 ! peptidase activator activity [Term] id: GO:0016506 name: apoptosis activator activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis." [GOC:hb] comment: This term was made obsolete because it represents involvement in a biological process. is_obsolete: true replaced_by: GO:0006917 [Term] id: GO:0016507 name: fatty acid beta-oxidation multienzyme complex namespace: cellular_component def: "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma] synonym: "trifunctional enzyme" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0016508 name: long-chain-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.74] synonym: "long-chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.74] synonym: "long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.74] xref: EC:4.2.1.74 xref: MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN xref: Reactome:25675 "long-chain-enoyl-CoA hydratase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0016509 name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. Long-chain fatty acids have a chain length of between 12 and 18 carbons." [EC:1.1.1.211, GOC:pde] comment: Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'. subset: gosubset_prok synonym: "beta-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.211] synonym: "LCHAD" RELATED [EC:1.1.1.211] synonym: "long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.211] synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.211] xref: EC:1.1.1.211 xref: MetaCyc:1.1.1.211-RXN xref: Reactome:25677 "long-chain-3-hydroxyacyl-CoA dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016511 name: endothelin-converting enzyme activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0016512 name: endothelin-converting enzyme 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [EC:3.4.24.71] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "ECE-1 activity" EXACT [EC:3.4.24.71] xref: EC:3.4.24.71 xref: MetaCyc:3.4.24.71-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0016513 name: core-binding factor complex namespace: cellular_component def: "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit." [PMID:15156179, PMID:8497254] synonym: "AML1 complex" NARROW [] synonym: "CBF complex" EXACT [] synonym: "PEPB2 complex" NARROW [] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0016514 name: SWI/SNF complex namespace: cellular_component def: "A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components." [GOC:mah, PMID:12672490] synonym: "SWI-SNF complex" EXACT [GOC:mah] is_a: GO:0070603 ! SWI/SNF-type complex [Term] id: GO:0016515 name: interleukin-13 receptor activity namespace: molecular_function def: "Combining with interleukin-13 to initiate a change in cell activity." [GOC:jl] synonym: "IL-13 receptor activity" EXACT [GOC:mah] synonym: "IL-13R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019973 ! interleukin-13 binding [Term] id: GO:0016516 name: interleukin-4 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor." [PMID:10358772] synonym: "IL-4 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0016517 name: interleukin-12 receptor activity namespace: molecular_function def: "Combining with interleukin-12 to initiate a change in cell activity." [GOC:jl] synonym: "IL-12 receptor activity" EXACT [GOC:mah] synonym: "IL-12R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019972 ! interleukin-12 binding [Term] id: GO:0016518 name: interleukin-14 receptor activity namespace: molecular_function def: "Combining with interleukin-14 to initiate a change in cell activity." [GOC:jl] synonym: "IL-14 receptor activity" EXACT [GOC:mah] synonym: "IL-14R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019974 ! interleukin-14 binding [Term] id: GO:0016519 name: gastric inhibitory peptide receptor activity namespace: molecular_function def: "Combining with gastric inhibitory peptide to initiate a change in cell activity." [GOC:mah, PMID:8243312] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0016520 name: growth hormone-releasing hormone receptor activity namespace: molecular_function def: "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [PMID:12529933] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0016521 name: pituitary adenylate cyclase activating polypeptide activity namespace: molecular_function def: "The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation." [GOC:mah, PMID:19805477] synonym: "pituitary adenylyl cyclase activating polypeptide activity" EXACT [] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016524 name: latrotoxin receptor activity namespace: molecular_function def: "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity." [GOC:jl, PMID:10025961] synonym: "latrophilin" NARROW [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0016525 name: negative regulation of angiogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators] synonym: "down regulation of angiogenesis" EXACT [] synonym: "down-regulation of angiogenesis" EXACT [] synonym: "downregulation of angiogenesis" EXACT [] synonym: "inhibition of angiogenesis" NARROW [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0001525 ! angiogenesis [Term] id: GO:0016527 name: brain-specific angiogenesis inhibitor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it is based on anatomical information, and describes at least one gene product. It has also never been defined. is_obsolete: true consider: GO:0004930 [Term] id: GO:0016528 name: sarcoplasm namespace: cellular_component def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684] xref: Wikipedia:Sarcoplasm is_a: GO:0005737 ! cytoplasm [Term] id: GO:0016529 name: sarcoplasmic reticulum namespace: cellular_component alt_id: GO:0008221 def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'. xref: Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0016528 ! sarcoplasm [Term] id: GO:0016530 name: metallochaperone activity namespace: molecular_function def: "Assists in the delivery of metal ions to target proteins or compartments." [GOC:jl, PMID:11739376] subset: goslim_pir subset: gosubset_prok is_a: GO:0003674 ! molecular_function [Term] id: GO:0016531 name: copper chaperone activity namespace: molecular_function def: "Assists in the delivery of copper ions to target proteins or compartments." [PMID:10790544, PMID:11739376] is_a: GO:0005507 ! copper ion binding is_a: GO:0016530 ! metallochaperone activity [Term] id: GO:0016532 name: superoxide dismutase copper chaperone activity namespace: molecular_function def: "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase." [http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:9295278] comment: See also the molecular function term 'superoxide dismutase activity ; GO:0004784'. is_a: GO:0016531 ! copper chaperone activity [Term] id: GO:0016533 name: cyclin-dependent protein kinase 5 holoenzyme complex namespace: cellular_component def: "A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [PMID:15689152] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex [Term] id: GO:0016534 name: cyclin-dependent protein kinase 5 activator activity namespace: molecular_function alt_id: GO:0016535 def: "Increases the activity of cyclin-dependent protein kinase 5." [GOC:mah] synonym: "cyclin-dependent protein kinase 5 activator, intrinsic catalyst activity" EXACT [] is_a: GO:0043539 ! protein serine/threonine kinase activator activity [Term] id: GO:0016536 name: cyclin-dependent protein kinase 5 activator regulator activity namespace: molecular_function def: "Modulation of the activity of cyclin-dependent protein kinase 5 activator." [GOC:ai] synonym: "cyclin-dependent protein kinase 5 activator, intrinsic regulator activity" NARROW [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0016538 name: cyclin-dependent protein kinase regulator activity namespace: molecular_function alt_id: GO:0003751 alt_id: GO:0003752 alt_id: GO:0003753 def: "Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:rn, PMID:7877684, PMID:9442875] synonym: "cyclin" BROAD [] synonym: "cyclin-dependent protein kinase, intrinsic regulator activity" NARROW [] synonym: "G1/S-specific cyclin" NARROW [] synonym: "G2/M-specific cyclin" NARROW [] xref: EC:2.7.1.- is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0016539 name: intein-mediated protein splicing namespace: biological_process def: "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html] subset: gosubset_prok synonym: "intein" RELATED [] is_a: GO:0030908 ! protein splicing [Term] id: GO:0016540 name: protein autoprocessing namespace: biological_process def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337] subset: gosubset_prok is_a: GO:0016485 ! protein processing [Term] id: GO:0016541 name: intein namespace: molecular_function def: "OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity." [GOC:mah, http://www.neb.com/neb/inteins.html, PMID:8165123] comment: This term was made obsolete because it refers to a protein sequence feature. is_obsolete: true consider: GO:0004519 consider: GO:0016539 [Term] id: GO:0016543 name: male courtship behavior, orientation prior to leg tapping and wing vibration namespace: biological_process def: "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster." [GOC:sensu, PMID:11092827] synonym: "male courtship behavior, orientation" RELATED [] synonym: "male courtship behaviour, orientation" RELATED [] synonym: "male courtship behaviour, orientation prior to leg tapping and wing vibration" RELATED [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0016544 name: male courtship behavior, tapping to detect pheromone namespace: biological_process def: "The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, tapping" RELATED [] synonym: "male courtship behaviour, tapping" EXACT [] synonym: "male courtship behaviour, tapping to detect pheromone" RELATED [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0016545 name: male courtship behavior, veined wing vibration namespace: biological_process def: "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, wing vibration" RELATED [] synonym: "male courtship behaviour, veined wing vibration" EXACT [] synonym: "male courtship behaviour, wing vibration" RELATED [] is_a: GO:0048065 ! male courtship behavior, veined wing extension [Term] id: GO:0016546 name: male courtship behavior, proboscis-mediated licking namespace: biological_process def: "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, licking" RELATED [] synonym: "male courtship behaviour, licking" RELATED [] synonym: "male courtship behaviour, proboscis-mediated licking" EXACT [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0016550 name: insertion or deletion editing namespace: biological_process def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription." [PMID:11092837] comment: This term was made obsolete because it represents two separate processes (insertion and deletion). synonym: "insertion/deletion editing" EXACT [] is_obsolete: true consider: GO:0070705 consider: GO:0070706 [Term] id: GO:0016551 name: posttranscriptional insertion or deletion editing namespace: biological_process def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription." [PMID:11092837] comment: This term was made obsolete because it represents two separate processes (insertion and deletion). synonym: "posttranscriptional insertion/deletion editing" EXACT [] is_obsolete: true consider: GO:0070705 consider: GO:0070706 [Term] id: GO:0016552 name: cotranscriptional insertion or deletion editing namespace: biological_process def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription." [PMID:11092837] comment: This term was made obsolete because it represents two separate processes (insertion and deletion). synonym: "cotranscriptional insertion/deletion editing" EXACT [] is_obsolete: true consider: GO:0070705 consider: GO:0070706 [Term] id: GO:0016553 name: base conversion or substitution editing namespace: biological_process def: "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s)." [PMID:11092837] subset: gosubset_prok synonym: "base conversion/substitution editing" EXACT [] is_a: GO:0009451 ! RNA modification [Term] id: GO:0016554 name: cytidine to uridine editing namespace: biological_process def: "The conversion of a cytosine residue to uridine in an RNA molecule by deamination." [PMID:11092837] subset: gosubset_prok xref: Reactome:1253108 "mRNA Editing: C to U Conversion" xref: Reactome:1280043 "mRNA Editing: C to U Conversion" xref: Reactome:1298928 "mRNA Editing: C to U Conversion" xref: Reactome:1326613 "mRNA Editing: C to U Conversion" xref: Reactome:1352726 "mRNA Editing: C to U Conversion" xref: Reactome:1372937 "mRNA Editing: C to U Conversion" xref: Reactome:1392953 "mRNA Editing: C to U Conversion" xref: Reactome:1417433 "mRNA Editing: C to U Conversion" xref: Reactome:1450526 "mRNA Editing: C to U Conversion" xref: Reactome:1496814 "mRNA Editing: C to U Conversion" xref: Reactome:1514208 "mRNA Editing: C to U Conversion" xref: Reactome:1521047 "mRNA Editing: C to U Conversion" xref: Reactome:72200 "mRNA Editing: C to U Conversion" is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0016555 name: uridine to cytidine editing namespace: biological_process def: "The conversion of a uridine residue to cytosine in an RNA molecule by amination." [PMID:11092837] subset: gosubset_prok is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0016556 name: mRNA modification namespace: biological_process alt_id: GO:0006381 def: "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. subset: gosubset_prok synonym: "mRNA editing" NARROW [GOC:dph, GOC:hjd, GOC:tb] xref: Reactome:1253045 "mRNA Editing" xref: Reactome:1279977 "mRNA Editing" xref: Reactome:1298868 "mRNA Editing" xref: Reactome:1326550 "mRNA Editing" xref: Reactome:1352662 "mRNA Editing" xref: Reactome:1372878 "mRNA Editing" xref: Reactome:1392898 "mRNA Editing" xref: Reactome:1417369 "mRNA Editing" xref: Reactome:1450470 "mRNA Editing" xref: Reactome:1471031 "mRNA Editing" xref: Reactome:1496815 "mRNA Editing" xref: Reactome:1514209 "mRNA Editing" xref: Reactome:1521048 "mRNA Editing" xref: Reactome:75072 "mRNA Editing" is_a: GO:0009451 ! RNA modification is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0016557 name: peroxisome membrane biogenesis namespace: biological_process def: "The process in which a peroxisome membrane is synthesized, aggregates, and bonds together." [GOC:mah] is_a: GO:0044091 ! membrane biogenesis relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0016558 name: protein import into peroxisome matrix namespace: biological_process def: "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported." [ISBN:0716731363, PMID:11687502, PMID:11988772] synonym: "peroxisome matrix protein import" EXACT [] synonym: "protein transport to peroxisome matrix" EXACT [] is_a: GO:0006625 ! protein targeting to peroxisome is_a: GO:0017038 ! protein import [Term] id: GO:0016559 name: peroxisome fission namespace: biological_process def: "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507] synonym: "peroxisome division" EXACT [] synonym: "peroxisome proliferation" EXACT [] is_a: GO:0048285 ! organelle fission relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0016560 name: protein import into peroxisome matrix, docking namespace: biological_process def: "The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the preoxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507] synonym: "peroxisome matrix protein import, docking" EXACT [] synonym: "peroxisome receptor docking" RELATED [] synonym: "protein docking during peroxisome matrix protein import" EXACT [] synonym: "protein docking during protein import into peroxisome matrix" EXACT [] synonym: "protein docking during protein transport into peroxisome matrix" EXACT [] synonym: "protein transport into peroxisome matrix, docking" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0016558 ! protein import into peroxisome matrix [Term] id: GO:0016561 name: protein import into peroxisome matrix, translocation namespace: biological_process def: "The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation." [PMID:11687502] synonym: "peroxisome matrix protein import, translocation" EXACT [] synonym: "peroxisome receptor translocation" RELATED [] synonym: "protein translocation during peroxisome matrix protein import" EXACT [] synonym: "protein translocation during protein import into peroxisome matrix" EXACT [] synonym: "protein translocation during protein transport into peroxisome matrix" EXACT [] synonym: "protein transport into peroxisome matrix, translocation" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0016558 ! protein import into peroxisome matrix [Term] id: GO:0016562 name: protein import into peroxisome matrix, receptor recycling namespace: biological_process def: "The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol." [PMID:11687502] synonym: "peroxisome matrix protein import, receptor recycling" EXACT [] synonym: "peroxisome receptor recycling" RELATED [] synonym: "protein transport into peroxisome matrix, receptor recycling" EXACT [] synonym: "PTS receptor recycling" RELATED [] synonym: "receptor recycling during peroxisome matrix protein import" EXACT [] synonym: "receptor recycling during protein import into peroxisome matrix" EXACT [] synonym: "receptor recycling during protein transport into peroxisome matrix" EXACT [] is_a: GO:0001881 ! receptor recycling relationship: part_of GO:0016558 ! protein import into peroxisome matrix [Term] id: GO:0016563 name: transcription activator activity namespace: molecular_function alt_id: GO:0003710 def: "OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok synonym: "transcription activating factor" NARROW [] synonym: "transcriptional activator activity" EXACT [] xref: Reactome:9388 "transcription activator activity" is_obsolete: true consider: GO:0000988 consider: GO:0001071 consider: GO:0045893 [Term] id: GO:0016564 name: transcription repressor activity namespace: molecular_function def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok synonym: "negative transcriptional regulator activity" EXACT [] synonym: "transcriptional repressor activity" EXACT [] is_obsolete: true consider: GO:0000988 consider: GO:0001071 consider: GO:0045892 [Term] id: GO:0016565 name: general transcriptional repressor activity namespace: molecular_function def: "OBSOLETE. Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah] comment: To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0001078 consider: GO:0001141 consider: GO:0045892 [Term] id: GO:0016566 name: specific transcriptional repressor activity namespace: molecular_function def: "OBSOLETE. Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah] comment: To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok is_obsolete: true consider: GO:0001078 consider: GO:0001141 consider: GO:0045892 [Term] id: GO:0016567 name: protein ubiquitination namespace: biological_process def: "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] synonym: "protein ubiquitinylation" EXACT [] synonym: "protein ubiquitylation" EXACT [] is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0016568 name: chromatin modification namespace: biological_process def: "The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure." [GOC:mah] subset: goslim_pombe is_a: GO:0006325 ! chromatin organization [Term] id: GO:0016569 name: covalent chromatin modification namespace: biological_process def: "The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah] is_a: GO:0016568 ! chromatin modification [Term] id: GO:0016570 name: histone modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc] xref: Wikipedia:Histone#Histone_modifications_in_chromatin_regulation is_a: GO:0006464 ! protein modification process is_a: GO:0016569 ! covalent chromatin modification [Term] id: GO:0016571 name: histone methylation namespace: biological_process def: "The modification of histones by addition of methyl groups." [GOC:ai] xref: Wikipedia:Histone_methylation is_a: GO:0006479 ! protein methylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016572 name: histone phosphorylation namespace: biological_process def: "The modification of histones by addition of phosphate groups." [GOC:ai] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016573 name: histone acetylation namespace: biological_process def: "The modification of a histone by the addition of an acetyl group." [GOC:ai] is_a: GO:0016570 ! histone modification is_a: GO:0018393 ! internal peptidyl-lysine acetylation [Term] id: GO:0016574 name: histone ubiquitination namespace: biological_process def: "The modification of histones by addition of ubiquitin groups." [GOC:ai] synonym: "histone ubiquitinylation" EXACT [] synonym: "histone ubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination is_a: GO:0016570 ! histone modification [Term] id: GO:0016575 name: histone deacetylation namespace: biological_process def: "The modification of histones by removal of acetyl groups." [GOC:ai] is_a: GO:0006476 ! protein deacetylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016576 name: histone dephosphorylation namespace: biological_process def: "The modification of histones by removal of phosphate groups." [GOC:ai] is_a: GO:0006470 ! protein dephosphorylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016577 name: histone demethylation namespace: biological_process def: "The modification of histones by removal of methyl groups." [GOC:ai] is_a: GO:0006482 ! protein demethylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016578 name: histone deubiquitination namespace: biological_process def: "The modification of histones by removal of ubiquitin groups." [GOC:ai] synonym: "histone deubiquitinylation" EXACT [] synonym: "histone deubiquitylation" EXACT [] is_a: GO:0016570 ! histone modification is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0016579 name: protein deubiquitination namespace: biological_process alt_id: GO:0006514 def: "The removal of one or more ubiquitin groups from a protein." [GOC:ai] synonym: "deubiquitination" EXACT [] synonym: "protein deubiquitinylation" EXACT [] synonym: "protein deubiquitylation" EXACT [] is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0016580 name: Sin3 complex namespace: cellular_component def: "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422] is_a: GO:0070822 ! Sin3-type complex [Term] id: GO:0016581 name: NuRD complex namespace: cellular_component def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569] synonym: "Mi-2 complex" EXACT [] synonym: "NRD complex" EXACT [] synonym: "nucleosome remodeling and histone deacetylation complex" EXACT [] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0017053 ! transcriptional repressor complex [Term] id: GO:0016582 name: non-covalent chromatin modification namespace: biological_process def: "The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups." [GOC:jl] is_a: GO:0016568 ! chromatin modification [Term] id: GO:0016583 name: nucleosome modeling namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it has been replaced by more specific terms. is_obsolete: true consider: GO:0006334 [Term] id: GO:0016584 name: nucleosome positioning namespace: biological_process def: "Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389] synonym: "nucleosome spacing" EXACT [] is_a: GO:0031497 ! chromatin assembly is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0016585 name: chromatin remodeling complex namespace: cellular_component alt_id: GO:0005679 def: "Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah] subset: goslim_pir synonym: "chromatin remodelling complex" EXACT [] synonym: "nucleosome remodeling complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0016586 name: RSC complex namespace: cellular_component def: "A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining." [PMID:11937489, PMID:12672490, PMID:15870268, PMID:8980231] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0016587 name: ISW1 complex namespace: cellular_component def: "A protein complex that contains an ISWI-family ATPase such as Saccharomyces Isw1p, and acts to modify chromatin structure." [GOC:mah, PMID:15020051] is_a: GO:0031010 ! ISWI complex [Term] id: GO:0016589 name: NURF complex namespace: cellular_component def: "A four subunit ISWI-containing protein complex that facilitates nucleosome mobility and transcriptional activation in an ATP-dependent manner. In contrast to other chromatin remodeling complexes, the ATPase activity of NURF requires nucleosomes rather than free DNA or histones." [GOC:bf, PMID:10779516, PMID:11279013] synonym: "nucleosome remodeling factor complex" EXACT [] is_a: GO:0031010 ! ISWI complex [Term] id: GO:0016590 name: ACF complex namespace: cellular_component def: "A chromatin-remodeling complex that catalyzes the ATP-dependent assembly of periodic nucleosome arrays. In Drosophila, the complex comprises ACF1 and ISWI." [GOC:bf, PMID:12192034] synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" EXACT [] is_a: GO:0005678 ! chromatin assembly complex [Term] id: GO:0016591 name: DNA-directed RNA polymerase II, holoenzyme namespace: cellular_component def: "Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0016592 name: mediator complex namespace: cellular_component alt_id: GO:0000119 def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] synonym: "CDK8-containing TRAP/mediator complex" RELATED [] synonym: "L mediator complex" EXACT [] synonym: "Srb-mediator complex" EXACT [GOC:mah] synonym: "TRAP complex" NARROW [] xref: Wikipedia:Mediator_(coactivator) is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0016593 name: Cdc73/Paf1 complex namespace: cellular_component def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586] synonym: "Paf1 complex" EXACT [GOC:cjk] synonym: "Paf1p complex" EXACT [GOC:cjk] is_a: GO:0008023 ! transcription elongation factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0016594 name: glycine binding namespace: molecular_function def: "Interacting selectively and non-covalently with glycine, aminoethanoic acid." [GOC:ai] synonym: "aminoacetic acid binding" EXACT [] synonym: "aminoethanoic acid binding" EXACT [] synonym: "Gly binding" EXACT [] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0016595 name: glutamate binding namespace: molecular_function def: "Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai] synonym: "glutamic acid binding" EXACT [] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0016596 name: thienylcyclohexylpiperidine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thienylcyclohexylpiperidine." [GOC:jl] synonym: "TCP binding" BROAD [] is_a: GO:0008144 ! drug binding [Term] id: GO:0016597 name: amino acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0043176 ! amine binding [Term] id: GO:0016598 name: protein arginylation namespace: biological_process alt_id: GO:0019130 def: "The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865] synonym: "protein amino acid arginylation" EXACT [] is_a: GO:0006464 ! protein modification process relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process [Term] id: GO:0016600 name: flotillin complex namespace: cellular_component def: "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709] comment: See also the cellular component term 'caveola ; GO:0005901'. is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005901 ! caveola [Term] id: GO:0016601 name: Rac protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Rac mediated signal transduction" EXACT [] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0016602 name: CCAAT-binding factor complex namespace: cellular_component def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [PMID:7828851] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0016603 name: glutaminyl-peptide cyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5] subset: gosubset_prok synonym: "glutaminyl cyclase activity" EXACT [EC:2.3.2.5] synonym: "glutaminyl-transfer ribonucleate cyclotransferase activity" EXACT [EC:2.3.2.5] synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5] synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.5] xref: EC:2.3.2.5 xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0016604 name: nuclear body namespace: cellular_component def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] xref: NIF_Subcellular:sao505137457 is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0016605 name: PML body namespace: cellular_component def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585] synonym: "ND10" EXACT [] synonym: "nuclear dot" RELATED [] synonym: "PML NB" EXACT [] synonym: "PML nuclear body" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0016606 name: LYSP100-associated nuclear domain namespace: cellular_component def: "A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies." [PMID:10921892, PMID:8695863] synonym: "LANDs" EXACT [PMID:8695863] is_a: GO:0016604 ! nuclear body [Term] id: GO:0016607 name: nuclear speck namespace: cellular_component def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] synonym: "nuclear speckle" EXACT [] synonym: "nuclear speckles" EXACT [] synonym: "speckle domain" NARROW [] synonym: "speckle focus" RELATED [] synonym: "splicing speckle" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0016608 name: growth hormone-releasing hormone activity namespace: molecular_function def: "The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland." [ISBN:0198506732] synonym: "GHRF activity" EXACT [ISBN:0198506732] synonym: "GHRH activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016610 name: nitrogenase complex namespace: cellular_component def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0016611 name: iron-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850] comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells. subset: gosubset_prok is_a: GO:0016610 ! nitrogenase complex [Term] id: GO:0016612 name: molybdenum-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1] subset: gosubset_prok synonym: "molybdenum-iron nitrogenase activity" RELATED [] is_a: GO:0016610 ! nitrogenase complex [Term] id: GO:0016613 name: vanadium-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027] subset: gosubset_prok synonym: "vanadium-iron nitrogenase activity" RELATED [] is_a: GO:0016610 ! nitrogenase complex [Term] id: GO:0016614 name: oxidoreductase activity, acting on CH-OH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.1.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW [] xref: EC:1.1 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016615 name: malate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] subset: gosubset_prok is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016616 name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.1.1 xref: Reactome:1519 "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016617 name: 4-oxoproline reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+." [EC:1.1.1.104] synonym: "4-hydroxy-L-proline:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.104] synonym: "hydroxy-L-proline oxidase activity" EXACT [] synonym: "hydroxyproline oxidase activity" EXACT [EC:1.1.1.104] xref: EC:1.1.1.104 xref: MetaCyc:4-OXOPROLINE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016618 name: hydroxypyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81] subset: gosubset_prok synonym: "beta-hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] synonym: "D-glycerate dehydrogenase activity" EXACT [EC:1.1.1.81] synonym: "D-glycerate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.81] synonym: "NADH:hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] xref: EC:1.1.1.81 xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016619 name: malate dehydrogenase (oxaloacetate-decarboxylating) activity namespace: molecular_function alt_id: GO:0004472 def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Also decarboxylates oxaloacetate." [EC:1.1.1.38] subset: gosubset_prok synonym: "'malic' enzyme" RELATED [EC:1.1.1.38] synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.38] synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38] synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38] synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38] xref: EC:1.1.1.38 xref: MetaCyc:MALIC-NAD-RXN is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016620 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.2.1 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016621 name: cinnamoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44] synonym: "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)" EXACT [EC:1.2.1.44] synonym: "cinnamoyl CoA reductase activity" EXACT [] synonym: "cinnamoyl-CoA:NADPH reductase activity" EXACT [EC:1.2.1.44] synonym: "cinnamoyl-coenzyme A reductase activity" EXACT [EC:1.2.1.44] synonym: "feruloyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] synonym: "feruloyl-CoA reductase activity" EXACT [EC:1.2.1.44] synonym: "ferulyl-CoA reductase activity" EXACT [EC:1.2.1.44] synonym: "p-hydroxycinnamoyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] xref: EC:1.2.1.44 xref: MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0016622 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok xref: EC:1.2.2 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016623 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.2.3 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016624 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor" EXACT [] xref: EC:1.2.4 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016625 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.2.7 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016626 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016903 [Term] id: GO:0016627 name: oxidoreductase activity, acting on the CH-CH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.3.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW [] xref: EC:1.3 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016628 name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.3.1 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016629 name: 12-oxophytodienoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + H(+) + NADPH." [EC:1.3.1.42, RHEA:21891] synonym: "12-oxo-phytodienoate reductase activity" EXACT [] synonym: "12-oxo-phytodienoic acid reductase activity" EXACT [EC:1.3.1.42] synonym: "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.42] xref: EC:1.3.1.42 xref: KEGG:R03401 xref: MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN xref: RHEA:21891 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016630 name: protochlorophyllide reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33] subset: gosubset_prok synonym: "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH-protochlorophyllide reductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH2-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "protochlorophyllide photooxidoreductase activity" EXACT [EC:1.3.1.33] xref: EC:1.3.1.33 xref: MetaCyc:RXN1F-10 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016631 name: enoyl-[acyl-carrier-protein] reductase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [EC:1.3.1.9, GOC:rb] subset: gosubset_prok synonym: "acyl-ACP dehydrogenase activity" EXACT [EC:1.3.1.-] synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT [] synonym: "enoyl-ACP reductase activity" EXACT [] synonym: "enoyl-acyl carrier protein reductase" EXACT [] xref: EC:1.3.1.- xref: MetaCyc:1.3.1.10-RXN xref: MetaCyc:1.3.1.39-RXN xref: MetaCyc:RXN1G-2527 xref: MetaCyc:RXN1G-2544 xref: MetaCyc:RXN1G-3232 xref: MetaCyc:RXN1G-3256 xref: MetaCyc:RXN1G-3613 xref: MetaCyc:RXN1G-3641 xref: MetaCyc:RXN1G-3667 xref: MetaCyc:RXN1G-3993 xref: MetaCyc:RXN1G-4140 xref: MetaCyc:RXN1G-45 xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016632 name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.3.2 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016633 name: galactonolactone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3] synonym: "GLDase activity" EXACT [EC:1.3.2.3] synonym: "GLDHase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-1,4-lactone dehydrogenase activity" EXACT [] synonym: "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-gamma-lactone dehydrogenase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] synonym: "L-galactonolactone dehydrogenase activity" EXACT [EC:1.3.2.3] xref: EC:1.3.2.3 xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor [Term] id: GO:0016634 name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.3.3 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016635 name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl] subset: gosubset_prok xref: EC:1.3.5 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016636 name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.3.7 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016637 name: oxidoreductase activity, acting on the CH-CH group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016627 [Term] id: GO:0016638 name: oxidoreductase activity, acting on the CH-NH2 group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.4.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW [] xref: EC:1.4 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016639 name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.4.1 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016640 name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] xref: EC:1.4.2 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016641 name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.4.3 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016642 name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor" EXACT [] xref: EC:1.4.4 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016643 name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.4.7 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016644 name: oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016638 [Term] id: GO:0016645 name: oxidoreductase activity, acting on the CH-NH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.5.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW [] xref: EC:1.5 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016646 name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.5.1 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016647 name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.5.3 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016648 name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] synonym: "oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor" EXACT [] xref: EC:1.5.4 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016649 name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl] subset: gosubset_prok xref: EC:1.5.5 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016650 name: oxidoreductase activity, acting on the CH-NH group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016645 [Term] id: GO:0016651 name: oxidoreductase activity, acting on NADH or NADPH namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.6.99.- should also be annotated to this term. subset: gosubset_prok synonym: "NAD(P)H dehydrogenase" NARROW [] synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW [] xref: EC:1.6 xref: Reactome:4134 "oxidoreductase activity, acting on NADH or NADPH" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016652 name: oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.6.1 is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0016653 name: oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT [] xref: EC:1.6.2 is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0016655 name: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.6.5 is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0016656 name: monodehydroascorbate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate." [EC:1.6.5.4] synonym: "AFR" RELATED [EC:1.6.5.4] synonym: "AFR-reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbate free radical reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbate free-radical reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbic free radical reductase activity" EXACT [EC:1.6.5.4] synonym: "MDAsA reductase (NADPH)" EXACT [EC:1.6.5.4] synonym: "MDHA" RELATED [EC:1.6.5.4] synonym: "monodehydroascorbate reductase activity" EXACT [] synonym: "NADH-semidehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:AFR oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:ascorbate radical oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:monodehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:semidehydroascorbic acid oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "SDA reductase activity" EXACT [EC:1.6.5.4] synonym: "semidehydroascorbate reductase activity" EXACT [EC:1.6.5.4] xref: EC:1.6.5.4 xref: MetaCyc:1.6.5.4-RXN is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: GO:0016657 name: oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai] subset: gosubset_prok xref: EC:1.6.6 is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0016658 name: oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it was a grouping term taken from EC that no longer has any functions associated with it. is_obsolete: true consider: GO:0008752 consider: GO:0042602 [Term] id: GO:0016659 name: oxidoreductase activity, acting on NADH or NADPH, other acceptor namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016651 [Term] id: GO:0016661 name: oxidoreductase activity, acting on other nitrogenous compounds as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.7.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" NARROW [] xref: EC:1.7 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016662 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok xref: EC:1.7.2 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016663 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.7.3 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016664 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.7.7 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016665 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016661 [Term] id: GO:0016667 name: oxidoreductase activity, acting on a sulfur group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.8.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW [] synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT [] xref: EC:1.8 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016668 name: oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor namespace: molecular_function alt_id: GO:0016654 def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT [] xref: EC:1.8.1 is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016669 name: oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor" EXACT [] xref: EC:1.8.2 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016670 name: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" EXACT [] xref: EC:1.8.3 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016671 name: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor" EXACT [] xref: EC:1.8.4 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016672 name: oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT [] xref: EC:1.8.5 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016673 name: oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.8.7 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016674 name: oxidoreductase activity, acting on sulfur group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on sulphur group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016667 [Term] id: GO:0016675 name: oxidoreductase activity, acting on a heme group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.9.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on haem group of donors" EXACT [] synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW [] xref: EC:1.9 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016676 name: oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT [] xref: EC:1.9.3 is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors [Term] id: GO:0016677 name: oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl] synonym: "oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor" EXACT [] xref: EC:1.9.6 is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors [Term] id: GO:0016678 name: oxidoreductase activity, acting on heme group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on haem group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016675 [Term] id: GO:0016679 name: oxidoreductase activity, acting on diphenols and related substances as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.10.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW [] xref: EC:1.10 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016680 name: oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.10.1 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0016681 name: oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok xref: EC:1.10.2 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0016682 name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok xref: EC:1.10.3 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0016683 name: oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016679 [Term] id: GO:0016684 name: oxidoreductase activity, acting on peroxide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok xref: EC:1.11 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016688 name: L-ascorbate peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O." [EC:1.11.1.11] synonym: "ascorbate peroxidase activity" EXACT [EC:1.11.1.11] synonym: "ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbic acid-specific peroxidase activity" EXACT [EC:1.11.1.11] xref: EC:1.11.1.11 xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016689 name: manganese peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O." [EC:1.11.1.13] synonym: "Mn(II):hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.13] synonym: "Mn-dependent (NADH-oxidizing) peroxidase activity" EXACT [EC:1.11.1.13] synonym: "Mn-dependent peroxidase activity" EXACT [EC:1.11.1.13] synonym: "peroxidase-M2" RELATED [EC:1.11.1.13] xref: EC:1.11.1.13 xref: MetaCyc:MANGANESE-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016690 name: diarylpropane peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-bis-(3,4-dimethoxyphenyl)propane-1,3-diol + H(2)O(2) = 1-(3,4-dimethoxyphenyl)ethane-1,2-diol + H(2)O + veratraldehyde." [EC:1.11.1.14, RHEA:17048] synonym: "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.14] synonym: "diarylpropane oxygenase activity" EXACT [EC:1.11.1.14] synonym: "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.11.1.14] synonym: "lignin peroxidase activity" EXACT [EC:1.11.1.14] synonym: "ligninase activity" EXACT [EC:1.11.1.14] synonym: "ligninase I activity" NARROW [EC:1.11.1.14] synonym: "LiP activity" NARROW [EC:1.11.1.14] xref: EC:1.11.1.14 xref: KEGG:R04461 xref: MetaCyc:DIARYLPROPANE-PEROXIDASE-RXN xref: RHEA:17048 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016691 name: chloride peroxidase activity namespace: molecular_function alt_id: GO:0016955 alt_id: GO:0016956 alt_id: GO:0016957 alt_id: GO:0016958 def: "Catalysis of the reaction: 2 R-H + 2 chloride + hydrogen peroxide = 2 R-Cl + 2 H2O." [EC:1.11.1.10] subset: gosubset_prok synonym: "chloride:hydrogen-peroxide oxidoreductase" EXACT [EC:1.11.1.10] synonym: "chloroperoxidase activity" EXACT [EC:1.11.1.10] synonym: "cofactor-free chloroperoxidase activity" NARROW [] synonym: "flavin-haem chloroperoxidase activity" NARROW [] synonym: "flavin-heme chloroperoxidase activity" NARROW [] synonym: "haem chloroperoxidase activity" NARROW [] synonym: "heme chloroperoxidase activity" NARROW [] synonym: "vanadium chloroperoxidase activity" NARROW [] xref: EC:1.11.1.10 xref: MetaCyc:CHLORIDE-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016692 name: NADH peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O(2) + H(+) + NADH = 2 H(2)O + NAD(+)." [EC:1.11.1.1, RHEA:18512] subset: gosubset_prok synonym: "diphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.1] synonym: "DPNH peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NAD peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NADH-peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NADH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.1] synonym: "nicotinamide adenine dinucleotide peroxidase activity" EXACT [EC:1.11.1.1] xref: EC:1.11.1.1 xref: KEGG:R00090 xref: MetaCyc:NADH-PEROXIDASE-RXN xref: RHEA:18512 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016694 name: bacterial catalase-peroxidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a bifunctional gene product. is_obsolete: true consider: GO:0004096 consider: GO:0004601 [Term] id: GO:0016695 name: oxidoreductase activity, acting on hydrogen as donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl] comment: Note that enzymes of class EC:1.12.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" NARROW [] xref: EC:1.12 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016696 name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.12.1 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0016697 name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor namespace: molecular_function alt_id: GO:0016698 def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok xref: EC:1.12.2 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0016699 name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor namespace: molecular_function alt_id: GO:0016736 alt_id: GO:0019110 def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.12.7 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0016700 name: oxidoreductase activity, acting on hydrogen as donor, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016695 [Term] id: GO:0016701 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah] comment: Note that enzymes of class EC:1.13.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" NARROW [] synonym: "oxygenase" BROAD [] xref: EC:1.13 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016702 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah] subset: gosubset_prok xref: EC:1.13.11 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0016703 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [GOC:mah] subset: gosubset_prok xref: EC:1.13.12 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0016704 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous namespace: molecular_function def: "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016701 [Term] id: GO:0016705 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] comment: Note that enzymes of class EC:1.14.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" NARROW [] xref: EC:1.14 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016706 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.11 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016707 name: gibberellin 3-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2." [EC:1.14.11.15, GOC:kad] synonym: "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15] synonym: "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15] synonym: "gibberellin 3-beta-hydroxylase activity" EXACT [EC:1.14.11.15] synonym: "gibberellin 3beta-dioxygenase activity" EXACT [EC:1.14.11.15] synonym: "gibberellin 3beta-hydroxylase activity" EXACT [EC:1.14.11.15] xref: EC:1.14.11.15 xref: MetaCyc:RXN1F-170 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0016708 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.12 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0016709 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.13 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016710 name: trans-cinnamate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.11] synonym: "CA4H activity" NARROW [EC:1.14.13.11] synonym: "cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamate 4-monooxygenase activity" EXACT [EC:1.14.13.11] synonym: "cinnamate hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic acid 4-monooxygenase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic acid p-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cytochrome P450 cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "hydroxylase, cinnamate 4-" EXACT [EC:1.14.13.11] synonym: "oxygenase, cinnamate 4-mono-" EXACT [EC:1.14.13.11] synonym: "t-cinnamic acid hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "trans-cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.11] synonym: "trans-cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11] xref: EC:1.14.13.11 xref: MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0016711 name: flavonoid 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.13.21] synonym: "flavonoid 3'-hydroxylase activity" EXACT [EC:1.14.13.21] synonym: "flavonoid 3-hydroxylase (erroneous)" EXACT [EC:1.14.13.21] synonym: "flavonoid 3-monooxygenase (erroneous)" EXACT [EC:1.14.13.21] synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.21] synonym: "NADPH:flavonoid-3'-hydroxylase activity" EXACT [EC:1.14.13.21] xref: EC:1.14.13.21 xref: MetaCyc:FLAVONOID-3-MONOOXYGENASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0016712 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen namespace: molecular_function alt_id: GO:0008402 alt_id: GO:0050381 def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok synonym: "aryl hydrocarbon hydroxylase activity" NARROW [EC:1.14.14.1] synonym: "aryl-4-monooxygenase activity" NARROW [EC:1.14.14.1] synonym: "cytochrome p450 activity" NARROW [EC:1.14.14.1] synonym: "cytochrome P450 CYP19" NARROW [] synonym: "flavoprotein monooxygenase activity" EXACT [EC:1.14.14.1] synonym: "flavoprotein-linked monooxygenase activity" EXACT [EC:1.14.14.1] synonym: "microsomal monooxygenase activity" NARROW [EC:1.14.14.1] synonym: "microsomal P-450" RELATED [EC:1.14.14.1] synonym: "microsomal p450 activity" NARROW [EC:1.14.14.1] synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" EXACT [EC:1.14.14.1] synonym: "unspecific monooxygenase activity" RELATED [] synonym: "xenobiotic monooxygenase activity" RELATED [EC:1.14.14.1] xref: EC:1.14.14 xref: Reactome:748 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" xref: UM-BBD_enzymeID:e0551 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016713 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen" EXACT [] xref: EC:1.14.15 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016714 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.16 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016715 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.17 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016716 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah] subset: gosubset_prok xref: EC:1.14.18 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016717 name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] subset: gosubset_prok xref: EC:1.14.19 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016718 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous namespace: molecular_function def: "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016705 [Term] id: GO:0016719 name: carotene 7,8-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O." [EC:1.14.99.30] subset: gosubset_prok synonym: "carotene,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.30] synonym: "zeta-carotene desaturase activity" EXACT [EC:1.14.99.30] xref: EC:1.14.99.30 xref: MetaCyc:1.14.99.30-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016720 name: delta12-fatty acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + linoleate + O(2) = A + crepenynate + 2 H(2)O." [EC:1.14.99.33, RHEA:23459] synonym: "crepenynate synthase activity" NARROW [EC:1.14.99.33] synonym: "D12-fatty acid dehydrogenase activity" EXACT [] synonym: "delta-12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] synonym: "delta12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] synonym: "linoleate delta-12-fatty acid acetylenase (desaturase) activity" EXACT [] synonym: "linoleate delta12-fatty acid acetylenase (desaturase)" EXACT [EC:1.14.99.33] synonym: "linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)" EXACT [EC:1.14.99.33] xref: EC:1.14.99.33 xref: KEGG:R05740 xref: MetaCyc:1.14.99.33-RXN xref: RHEA:23459 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016721 name: oxidoreductase activity, acting on superoxide radicals as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok xref: EC:1.15 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016722 name: oxidoreductase activity, oxidizing metal ions namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah] subset: gosubset_prok xref: EC:1.16 xref: Reactome:870 "oxidoreductase activity, oxidizing metal ions" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016723 name: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah] subset: gosubset_prok xref: EC:1.16.1 xref: Reactome:882 "oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor" is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions [Term] id: GO:0016724 name: oxidoreductase activity, oxidizing metal ions, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah] subset: gosubset_prok xref: EC:1.16.3 is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions [Term] id: GO:0016725 name: oxidoreductase activity, acting on CH or CH2 groups namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.17.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on CH or CH2 groups, other acceptors" NARROW [] xref: EC:1.17 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016726 name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.17.1 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0016727 name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.17.3 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0016728 name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor" EXACT [] xref: EC:1.17.4 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0016729 name: oxidoreductase activity, acting on CH2 groups, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016725 [Term] id: GO:0016730 name: oxidoreductase activity, acting on iron-sulfur proteins as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on iron-sulphur proteins as donors" EXACT [] xref: EC:1.18 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016731 name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.18.1 is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0016732 name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] subset: gosubset_prok xref: EC:1.18.6 is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0016733 name: iron-iron nitrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] comment: This term was made obsolete because it represents a cellular component. is_obsolete: true replaced_by: GO:0016163 replaced_by: GO:0016611 [Term] id: GO:0016734 name: molybdenum-iron nitrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] comment: This term was made obsolete because it represents a cellular component. is_obsolete: true replaced_by: GO:0016163 replaced_by: GO:0016612 [Term] id: GO:0016735 name: vanadium-iron nitrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] comment: This term was made obsolete because it represents a cellular component. is_obsolete: true replaced_by: GO:0016163 replaced_by: GO:0016613 [Term] id: GO:0016737 name: oxidoreductase activity, acting on reduced flavodoxin as donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok xref: EC:1.19 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016738 name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] subset: gosubset_prok xref: EC:1.19.6 is_a: GO:0016737 ! oxidoreductase activity, acting on reduced flavodoxin as donor [Term] id: GO:0016739 name: oxidoreductase activity, acting on other substrates namespace: molecular_function def: "OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016491 [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: EC:2 xref: Reactome:430 "transferase activity" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016741 name: transferase activity, transferring one-carbon groups namespace: molecular_function def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016742 name: hydroxymethyl-, formyl- and related transferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah] subset: gosubset_prok xref: EC:2.1.2 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups [Term] id: GO:0016743 name: carboxyl- or carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "carboxyl- and carbamoyltransferase activity" EXACT [] xref: EC:2.1.3 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups [Term] id: GO:0016744 name: transferase activity, transferring aldehyde or ketonic groups namespace: molecular_function alt_id: GO:0016745 def: "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "transketolase or transaldolase activity" EXACT [] xref: EC:2.2 xref: EC:2.2.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016746 name: transferase activity, transferring acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.3 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016747 name: transferase activity, transferring acyl groups other than amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "transferase activity, transferring groups other than amino-acyl groups" EXACT [EC:2.3.1] xref: EC:2.3.1 is_a: GO:0016746 ! transferase activity, transferring acyl groups [Term] id: GO:0016748 name: succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0016749 name: N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0016748 ! succinyltransferase activity [Term] id: GO:0016750 name: O-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016748 ! succinyltransferase activity [Term] id: GO:0016751 name: S-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0016417 ! S-acyltransferase activity is_a: GO:0016748 ! succinyltransferase activity [Term] id: GO:0016752 name: sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0016753 name: O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016752 ! sinapoyltransferase activity [Term] id: GO:0016754 name: sinapoylglucose-malate O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate." [EC:2.3.1.92, RHEA:12628] synonym: "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity" EXACT [EC:2.3.1.92] synonym: "1-sinapoylglucose-L-malate sinapoyltransferase activity" EXACT [EC:2.3.1.92] synonym: "sinapoylglucose:malate sinapoyltransferase activity" EXACT [] xref: EC:2.3.1.92 xref: KEGG:R03323 xref: MetaCyc:2.3.1.92-RXN xref: RHEA:12628 is_a: GO:0016753 ! O-sinapoyltransferase activity [Term] id: GO:0016755 name: transferase activity, transferring amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "aminoacyltransferase activity" EXACT [] xref: EC:2.3.2 is_a: GO:0016746 ! transferase activity, transferring acyl groups [Term] id: GO:0016756 name: glutathione gamma-glutamylcysteinyltransferase activity namespace: molecular_function alt_id: GO:0042143 def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15] synonym: "gamma-glutamylcysteine dipeptidyl transpeptidase activity" EXACT [EC:2.3.2.15] synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity" EXACT [EC:2.3.2.15] synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15] xref: EC:2.3.2.15 xref: MetaCyc:2.3.2.15-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0016757 name: transferase activity, transferring glycosyl groups namespace: molecular_function alt_id: GO:0016932 def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that enzymes of class EC:2.4.99.- should also be annotated to this term. subset: gosubset_prok synonym: "glycosyltransferase activity" EXACT [] synonym: "transferase activity, transferring other glycosyl groups" NARROW [] synonym: "transglycosidase activity" EXACT [] synonym: "transglycosylase activity" EXACT [] xref: EC:2.4 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016758 name: transferase activity, transferring hexosyl groups namespace: molecular_function def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "hexosyltransferase activity" EXACT [] xref: EC:2.4.1 is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0016759 name: cellulose synthase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12, EC:2.4.1.29] subset: gosubset_prok synonym: "cellulose synthetase activity" EXACT [EC:2.4.1.29] xref: EC:2.4.1.- is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0016760 name: cellulose synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12] subset: gosubset_prok synonym: "1,4-beta-D-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "1,4-beta-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucan synthetase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "beta-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "GS-I" RELATED [EC:2.4.1.12] synonym: "UDP-glucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] xref: EC:2.4.1.12 xref: MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN is_a: GO:0016759 ! cellulose synthase activity is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0016761 name: cellulose synthase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29] synonym: "cellulose synthase (guanosine diphosphate-forming) activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] xref: EC:2.4.1.29 xref: MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN is_a: GO:0016759 ! cellulose synthase activity [Term] id: GO:0016762 name: xyloglucan:xyloglucosyl transferase activity namespace: molecular_function def: "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207] synonym: "endo-xyloglucan transferase activity" EXACT [EC:2.4.1.207] synonym: "endoxyloglucan transferase activity" EXACT [] synonym: "xyloglucan endotransglycosylase activity" EXACT [EC:2.4.1.207] synonym: "xyloglucan:xyloglucan xyloglucanotransferase activity" EXACT [EC:2.4.1.207] xref: EC:2.4.1.207 xref: MetaCyc:2.4.1.207-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0016763 name: transferase activity, transferring pentosyl groups namespace: molecular_function def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "pentosyltransferase activity" EXACT [] xref: EC:2.4.2 xref: Reactome:1245 "transferase activity, transferring pentosyl groups" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0016764 name: transferase activity, transferring other glycosyl groups namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor)." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016757 [Term] id: GO:0016765 name: transferase activity, transferring alkyl or aryl (other than methyl) groups namespace: molecular_function alt_id: GO:0016766 def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT [] xref: EC:2.5 xref: EC:2.5.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016767 name: geranylgeranyl-diphosphate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [EC:2.5.1.32] subset: gosubset_prok synonym: "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.32] synonym: "phytoene synthetase activity" EXACT [EC:2.5.1.32] synonym: "prephytoene-diphosphate synthase activity" EXACT [EC:2.5.1.32] synonym: "PSase activity" EXACT [EC:2.5.1.32] xref: EC:2.5.1.32 xref: MetaCyc:2.5.1.32-RXN is_a: GO:0004337 ! geranyltranstransferase activity [Term] id: GO:0016768 name: spermine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22] synonym: "S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.22] synonym: "spermidine aminopropyltransferase activity" EXACT [EC:2.5.1.22] synonym: "spermine synthetase activity" EXACT [EC:2.5.1.22] xref: EC:2.5.1.22 xref: MetaCyc:SPERMINE-SYNTHASE-RXN xref: Reactome:1269 "spermine synthase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0016769 name: transferase activity, transferring nitrogenous groups namespace: molecular_function def: "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that enzymes of class EC:2.6.99.- should also be annotated to this term. subset: gosubset_prok synonym: "transferase activity, transferring other nitrogenous groups" NARROW [] xref: EC:2.6 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016770 name: oximinotransaminase activity namespace: molecular_function def: "Catalysis of the reversible transfer of an oxime group to an acceptor." [GOC:ai] xref: EC:2.6.3 is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0016771 name: transferase activity, transferring other nitrogenous groups namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor)." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016769 [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: gosubset_prok xref: EC:2.7 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016773 name: phosphotransferase activity, alcohol group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.1 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016774 name: phosphotransferase activity, carboxyl group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.2 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016775 name: phosphotransferase activity, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.3 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016776 name: phosphotransferase activity, phosphate group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.4 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016778 name: diphosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] subset: gosubset_prok xref: EC:2.7.6 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016779 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_yeast subset: gosubset_prok xref: EC:2.7.7 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016780 name: phosphotransferase activity, for other substituted phosphate groups namespace: molecular_function def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] subset: gosubset_prok xref: EC:2.7.8 xref: Reactome:1452 "phosphotransferase activity, for other substituted phosphate groups" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016781 name: phosphotransferase activity, paired acceptors namespace: molecular_function def: "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] subset: gosubset_prok xref: EC:2.7.9 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016782 name: transferase activity, transferring sulfur-containing groups namespace: molecular_function def: "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "transferase activity, transferring sulphur-containing groups" EXACT [] xref: EC:2.8 xref: Reactome:1470 "transferase activity, transferring sulfur-containing groups" is_a: GO:0016740 ! transferase activity [Term] id: GO:0016783 name: sulfurtransferase activity namespace: molecular_function def: "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "sulphurtransferase activity" EXACT [] synonym: "tRNA sulfurtransferase activity" NARROW [GOC:mah] xref: EC:2.8.1 xref: Reactome:1481 "sulfurtransferase activity" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0016784 name: 3-mercaptopyruvate sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate." [EC:2.8.1.2] subset: gosubset_prok synonym: "3-mercaptopyruvate sulphurtransferase activity" EXACT [] synonym: "3-mercaptopyruvate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.2] synonym: "beta-mercaptopyruvate sulfurtransferase activity" EXACT [EC:2.8.1.2] synonym: "mercaptopyruvate sulfurtransferase activity" EXACT [] xref: EC:2.8.1.2 xref: MetaCyc:MERCAPYSTRANS-RXN is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0016785 name: transferase activity, transferring selenium-containing groups namespace: molecular_function alt_id: GO:0016786 def: "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "selenotransferase activity" EXACT [] xref: EC:2.9 xref: EC:2.9.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: EC:3 xref: Reactome:450 "hydrolase activity" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016788 name: hydrolase activity, acting on ester bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl] subset: gosubset_prok synonym: "esterase activity" EXACT [] xref: EC:3.1 xref: Reactome:448 "hydrolase activity, acting on ester bonds" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016790 name: thiolester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com] subset: gosubset_prok synonym: "thiolesterase activity" EXACT [] xref: EC:3.1.2 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0016791 name: phosphatase activity namespace: molecular_function alt_id: GO:0016302 def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators] subset: gosubset_prok synonym: "phosphatase" RELATED [] synonym: "phosphoric monoester hydrolase activity" EXACT [] xref: EC:3.1.3 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016793 name: triphosphoric monoester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai] subset: gosubset_prok xref: EC:3.1.5 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016794 name: diphosphoric monoester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group." [GOC:ai] subset: gosubset_prok xref: EC:3.1.7 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016795 name: phosphoric triester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a phosphoric triester." [EC:3.1.8, GOC:curators] xref: EC:3.1.8 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016796 name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.15 is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0016797 name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok xref: EC:3.1.16 is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0016798 name: hydrolase activity, acting on glycosyl bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] subset: gosubset_prok synonym: "glycosidase activity" EXACT [] synonym: "glycosylase" NARROW [] synonym: "N-glycosylase" NARROW [] xref: EC:3.2 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016799 name: hydrolase activity, hydrolyzing N-glycosyl compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl] subset: gosubset_prok xref: EC:3.2.2 is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] id: GO:0016801 name: hydrolase activity, acting on ether bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl] subset: gosubset_prok xref: EC:3.3 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016802 name: trialkylsulfonium hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a thioether bond, -S-." [EC:3.3.1.-, GOC:ai] subset: gosubset_prok synonym: "thioether hydrolase activity" EXACT [] synonym: "trialkylsulphonium hydrolase activity" EXACT [] xref: EC:3.3.1.- is_a: GO:0016801 ! hydrolase activity, acting on ether bonds [Term] id: GO:0016803 name: ether hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai] subset: gosubset_prok xref: EC:3.3.2 is_a: GO:0016801 ! hydrolase activity, acting on ether bonds [Term] id: GO:0016804 name: prolyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. subset: gosubset_prok synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5] synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5] synonym: "proline iminopeptidase activity" EXACT [] xref: EC:3.4.11.5 xref: MetaCyc:3.4.11.5-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0016805 name: dipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com] subset: gosubset_prok xref: EC:3.4.13 xref: Reactome:2731 "dipeptidase activity" is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0016806 name: dipeptidyl-peptidase and tripeptidyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai] comment: This term was made obsolete because it represents two activities. subset: gosubset_prok xref: EC:3.4.14 is_obsolete: true [Term] id: GO:0016807 name: cysteine-type carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] xref: EC:3.4.18 xref: MetaCyc:3.4.18.1-RXN is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0070004 ! cysteine-type exopeptidase activity [Term] id: GO:0016808 name: proprotein convertase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.21.- is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0016810 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] comment: Note that enzymes of class EC:3.5.99.- should also be annotated to this term. subset: gosubset_prok synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] xref: EC:3.5 xref: Reactome:1718 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016811 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] subset: gosubset_prok xref: EC:3.5.1 xref: Reactome:1716 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016812 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai] subset: gosubset_prok xref: EC:3.5.2 xref: Reactome:2753 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides" is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016813 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.5.3 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016814 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.5.4 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016815 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [http://www.onelook.com/] subset: gosubset_prok xref: EC:3.5.5 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016816 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016810 [Term] id: GO:0016817 name: hydrolase activity, acting on acid anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] subset: gosubset_prok synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] xref: EC:3.6 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016818 name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] subset: gosubset_prok xref: EC:3.6.1 is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides [Term] id: GO:0016819 name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai] synonym: "hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides" EXACT [] xref: EC:3.6.2 is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides [Term] id: GO:0016820 name: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances namespace: molecular_function def: "Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah] subset: gosubset_prok xref: EC:3.6.3 is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0016821 name: hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it incorporates process information. is_obsolete: true replaced_by: GO:0016817 [Term] id: GO:0016822 name: hydrolase activity, acting on acid carbon-carbon bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-carbon bond." [GOC:jl] subset: gosubset_prok xref: EC:3.7 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016823 name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [GOC:ai] subset: gosubset_prok xref: EC:3.7.1 is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds [Term] id: GO:0016824 name: hydrolase activity, acting on acid halide bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid halide bond." [GOC:jl] subset: gosubset_prok xref: EC:3.8 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016825 name: hydrolase activity, acting on acid phosphorus-nitrogen bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl] xref: EC:3.9 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016826 name: hydrolase activity, acting on acid sulfur-nitrogen bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond." [GOC:jl] synonym: "hydrolase activity, acting on acid sulphur-nitrogen bonds" EXACT [] xref: EC:3.10 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016827 name: hydrolase activity, acting on acid carbon-phosphorus bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-phosphorus bond." [GOC:jl] subset: gosubset_prok xref: EC:3.11 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016828 name: hydrolase activity, acting on acid sulfur-sulfur bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid sulfur-sulfur bond." [GOC:jl] synonym: "hydrolase activity, acting on acid sulphur-sulphur bonds" EXACT [] xref: EC:3.12 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016829 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term. subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "other lyase activity" NARROW [] xref: EC:4 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016830 name: carbon-carbon lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] comment: Note that enzymes of class EC:4.1.99.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-carbon lyase activity" NARROW [] xref: EC:4.1 xref: Reactome:1006 "carbon-carbon lyase activity" is_a: GO:0016829 ! lyase activity [Term] id: GO:0016831 name: carboxy-lyase activity namespace: molecular_function def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/] subset: gosubset_prok synonym: "decarboxylase activity" EXACT [] xref: EC:4.1.1 xref: Reactome:1605 "carboxy-lyase activity" is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0016832 name: aldehyde-lyase activity namespace: molecular_function alt_id: GO:0016228 def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/] subset: gosubset_prok synonym: "aldolase activity" BROAD [] xref: EC:4.1.2 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0016833 name: oxo-acid-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3, GOC:jl] subset: gosubset_prok synonym: "oxo-acid lyase activity" EXACT [] synonym: "oxoacid lyase activity" EXACT [] xref: EC:4.1.3 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0016834 name: other carbon-carbon lyase activity namespace: molecular_function def: "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016830 [Term] id: GO:0016835 name: carbon-oxygen lyase activity namespace: molecular_function def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-] comment: Note that enzymes of class EC:4.2.99.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-oxygen lyase activity" NARROW [] xref: EC:4.2 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016836 name: hydro-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1] subset: gosubset_prok xref: EC:4.2.1 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0016837 name: carbon-oxygen lyase activity, acting on polysaccharides namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [EC:4.2.-.-] subset: gosubset_prok xref: EC:4.2.2 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0016838 name: carbon-oxygen lyase activity, acting on phosphates namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [EC:4.2.-.-] subset: gosubset_prok xref: EC:4.2.3 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0016839 name: other carbon-oxygen lyase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases." [GOC:krc] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016835 [Term] id: GO:0016840 name: carbon-nitrogen lyase activity namespace: molecular_function def: "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-] comment: Note that enzymes of class EC:4.3.99.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-nitrogen lyase activity" NARROW [] xref: EC:4.3 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016841 name: ammonia-lyase activity namespace: molecular_function def: "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc] subset: gosubset_prok xref: EC:4.3.1 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0016842 name: amidine-lyase activity namespace: molecular_function def: "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc] subset: gosubset_prok xref: EC:4.3.2 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0016843 name: amine-lyase activity namespace: molecular_function def: "Catalysis of the release of amides by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [EC:4.3.-.-, GOC:krc] subset: gosubset_prok xref: EC:4.3.3 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0016844 name: strictosidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15016] subset: gosubset_prok synonym: "3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.2] synonym: "3-alpha(S)-strictosidine tryptamine-lyase activity" EXACT [EC:4.3.3.2] synonym: "STR activity" EXACT [EC:4.3.3.2] synonym: "strictosidine synthetase activity" EXACT [EC:4.3.3.2] xref: EC:4.3.3.2 xref: KEGG:R03738 xref: MetaCyc:STRICTOSIDINE-SYNTHASE-RXN xref: RHEA:15016 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0016845 name: other carbon-nitrogen lyase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases." [GOC:krc] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016840 [Term] id: GO:0016846 name: carbon-sulfur lyase activity namespace: molecular_function def: "Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-] subset: gosubset_prok synonym: "carbon-sulphur lyase activity" EXACT [] xref: EC:4.4 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016847 name: 1-aminocyclopropane-1-carboxylate synthase activity namespace: molecular_function alt_id: GO:0034100 def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)." [EC:4.4.1.14, RHEA:21747] comment: Note that this function was formerly EC:4.1.99.4. subset: gosubset_prok synonym: "1-aminocyclopropane-1-carboxylate synthetase activity" EXACT [EC:4.4.1.14] synonym: "1-aminocyclopropane-1-carboxylic acid synthase activity" EXACT [EC:4.4.1.14] synonym: "1-aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] synonym: "ACC synthase activity" EXACT [EC:4.4.1.14] synonym: "aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] synonym: "aminocyclopropanecarboxylic acid synthase activity" EXACT [EC:4.4.1.14] synonym: "L-VG deaminase activity" RELATED [PMID:11470512] synonym: "L-vinylglycine deaminase activity" RELATED [PMID:11470512] synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)" EXACT [EC:4.4.1.14] synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase activity" EXACT [EC:4.4.1.14] xref: EC:4.4.1.14 xref: KEGG:R00179 xref: MetaCyc:4.4.1.14-RXN xref: RHEA:21747 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0016848 name: carbon-halide lyase activity namespace: molecular_function def: "Catalysis of the breakage of a bond between carbon and any halogen atom." [GOC:mah] subset: gosubset_prok xref: EC:4.5 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016849 name: phosphorus-oxygen lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] subset: gosubset_prok xref: EC:4.6 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016850 name: other lyase activity namespace: molecular_function def: "OBSOLETE. A grouping term for lyases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016829 [Term] id: GO:0016851 name: magnesium chelatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13964] comment: Note that this was EC:4.99.1.1. subset: gosubset_prok synonym: "magnesium-chelatase activity" EXACT [EC:6.6.1.1] synonym: "magnesium-protoporphyrin chelatase activity" EXACT [EC:6.6.1.1] synonym: "magnesium-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] synonym: "Mg-chelatase activity" BROAD [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX magnesio-lyase activity" EXACT [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX magnesium-lyase activity" EXACT [EC:6.6.1.1] synonym: "protoporphyrin IX magnesium-chelatase activity" EXACT [EC:6.6.1.1] synonym: "protoporphyrin IX Mg-chelatase activity" EXACT [EC:6.6.1.1] xref: EC:6.6.1.1 xref: KEGG:R03877 xref: MetaCyc:RXN1F-20 xref: RHEA:13964 is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes [Term] id: GO:0016852 name: sirohydrochlorin cobaltochelatase activity namespace: molecular_function def: "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [EC:4.99.1.3] subset: gosubset_prok synonym: "anaerobic cobalt chelatase activity" EXACT [] synonym: "CbiK" NARROW [] synonym: "CbiX" RELATED [EC:4.99.1.3] synonym: "CbiXS" RELATED [EC:4.99.1.3] synonym: "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.3] synonym: "sirohydrochlorin cobalt-lyase activity" EXACT [EC:4.99.1.3] xref: EC:4.99.1.3 xref: MetaCyc:4.99.1.3-RXN is_a: GO:0016829 ! lyase activity [Term] id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term. subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "other isomerase activity" NARROW [] xref: EC:5 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016854 name: racemase and epimerase activity namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that enzymes of class EC:5.1.99.- should also be annotated to this term. Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound. subset: gosubset_prok synonym: "racemase and epimerase activity, acting on other compounds" NARROW [] xref: EC:5.1 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016855 name: racemase and epimerase activity, acting on amino acids and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah] subset: gosubset_prok xref: EC:5.1.1 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0016856 name: racemase and epimerase activity, acting on hydroxy acids and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.1.2 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0016857 name: racemase and epimerase activity, acting on carbohydrates and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.1.3 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0016858 name: racemase and epimerase activity, acting on other compounds namespace: molecular_function def: "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016854 [Term] id: GO:0016859 name: cis-trans isomerase activity namespace: molecular_function def: "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:5.2 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016860 name: intramolecular oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-] comment: Note that enzymes of class EC:5.3.99.- should also be annotated to this term. subset: gosubset_prok synonym: "intramolecular isomerase activity" EXACT [] synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW [] xref: EC:5.3 xref: Reactome:1429 "intramolecular oxidoreductase activity" is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016861 name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl] subset: gosubset_prok synonym: "intramolecular isomerase activity, interconverting aldoses and ketoses" EXACT [] xref: EC:5.3.1 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016862 name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears." [GOC:jl] subset: gosubset_prok synonym: "intramolecular isomerase activity, interconverting keto- and enol-groups" EXACT [] xref: EC:5.3.2 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016863 name: intramolecular oxidoreductase activity, transposing C=C bonds namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3, GOC:mah] subset: gosubset_prok synonym: "intramolecular isomerase activity, transposing C=C bonds" EXACT [] xref: EC:5.3.3 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016864 name: intramolecular oxidoreductase activity, transposing S-S bonds namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4, GOC:mah] subset: gosubset_prok synonym: "intramolecular isomerase activity, transposing S-S bonds" EXACT [] xref: EC:5.3.4 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016865 name: intramolecular oxidoreductase activity, other intramolecular oxidoreductases namespace: molecular_function def: "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "intramolecular isomerase activity, other intramolecular oxidoreductases" EXACT [] is_obsolete: true consider: GO:0016860 [Term] id: GO:0016866 name: intramolecular transferase activity namespace: molecular_function def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah] comment: Note that enzymes of class EC:5.4.99.- should also be annotated to this term. subset: gosubset_prok synonym: "intramolecular transferase activity, transferring other groups" NARROW [] synonym: "mutase activity" EXACT [] xref: EC:5.4 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016867 name: intramolecular transferase activity, transferring acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.4.1 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0016868 name: intramolecular transferase activity, phosphotransferases namespace: molecular_function alt_id: GO:0016777 def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok synonym: "phosphomutase activity" EXACT [] synonym: "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers" EXACT [] xref: EC:5.4.2 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0016869 name: intramolecular transferase activity, transferring amino groups namespace: molecular_function def: "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.4.3 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0016870 name: intramolecular transferase activity, transferring other groups namespace: molecular_function def: "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016866 [Term] id: GO:0016871 name: cycloartenol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol." [EC:5.4.99.8, RHEA:21311] subset: gosubset_prok synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)" EXACT [EC:5.4.99.8] synonym: "2,3-epoxysqualene cycloartenol-cyclase activity" EXACT [EC:5.4.99.8] synonym: "2,3-epoxysqualene--cycloartenol cyclase activity" EXACT [EC:5.4.99.8] synonym: "2,3-oxidosqualene-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] synonym: "oxidosqualene:cycloartenol cyclase activity" EXACT [PMID:18033581] synonym: "squalene-2,3-epoxide-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] xref: EC:5.4.99.8 xref: KEGG:R03200 xref: MetaCyc:CYCLOARTENOL-SYNTHASE-RXN xref: RHEA:21311 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0016872 name: intramolecular lyase activity namespace: molecular_function def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/] subset: gosubset_prok xref: EC:5.5 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016873 name: other isomerase activity namespace: molecular_function def: "OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016853 [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: EC:6 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016875 name: ligase activity, forming carbon-oxygen bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.1, GOC:mah] subset: gosubset_prok xref: EC:6.1 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016876 name: ligase activity, forming aminoacyl-tRNA and related compounds namespace: molecular_function def: "Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah] subset: gosubset_prok xref: EC:6.1.1 is_a: GO:0016875 ! ligase activity, forming carbon-oxygen bonds [Term] id: GO:0016877 name: ligase activity, forming carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2, GOC:mah] subset: gosubset_prok synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] xref: EC:6.2 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016878 name: acid-thiol ligase activity namespace: molecular_function def: "Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1, GOC:mah] subset: gosubset_prok xref: EC:6.2.1 is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0016879 name: ligase activity, forming carbon-nitrogen bonds namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3, GOC:mah] comment: Note that enzymes of class EC:6.3.4.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-nitrogen ligase activity" NARROW [] xref: EC:6.3 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016880 name: acid-ammonia (or amide) ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] subset: gosubset_prok synonym: "amide synthase activity" EXACT [] xref: EC:6.3.1 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016881 name: acid-amino acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] subset: gosubset_prok synonym: "peptide synthase activity" EXACT [] xref: EC:6.3.2 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016882 name: cyclo-ligase activity namespace: molecular_function def: "Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:jl, GOC:mah] subset: gosubset_prok xref: EC:6.3.3 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016883 name: other carbon-nitrogen ligase activity namespace: molecular_function def: "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016879 [Term] id: GO:0016884 name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor namespace: molecular_function alt_id: GO:0016003 def: "Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532] subset: gosubset_prok xref: EC:6.3.5 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016885 name: ligase activity, forming carbon-carbon bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4, GOC:jl, GOC:mah] subset: gosubset_prok xref: EC:6.4 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016886 name: ligase activity, forming phosphoric ester bonds namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.5, GOC:mah] subset: gosubset_prok xref: EC:6.5 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016887 name: ATPase activity namespace: molecular_function alt_id: GO:0004002 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "(Ca2+ + Mg2+)-ATPase" NARROW [EC:3.6.1.3] synonym: "adenosine 5'-triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosine triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosinetriphosphatase activity" EXACT [] synonym: "ATP hydrolase activity" EXACT [EC:3.6.1.3] synonym: "ATP monophosphatase activity" EXACT [EC:3.6.1.3] synonym: "ATP phosphohydrolase activity" EXACT [] synonym: "complex V (mitochondrial electron transport)" RELATED [EC:3.6.1.3] synonym: "HCO3--ATPase" NARROW [EC:3.6.1.3] synonym: "SV40 T-antigen" RELATED [EC:3.6.1.3] xref: EC:3.6.1.3 xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN xref: Reactome:1401 "ATPase activity" xref: RHEA:13068 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0016888 name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "endodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.21 xref: Reactome:3134 "endodeoxyribonuclease activity, producing 5'-phosphomonoesters" is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016889 name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] xref: EC:3.1.22 is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: GO:0016890 name: site-specific endodeoxyribonuclease activity, specific for altered base namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl] subset: gosubset_prok xref: EC:3.1.25 is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0016891 name: endoribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] subset: gosubset_prok xref: EC:3.1.26 is_a: GO:0004521 ! endoribonuclease activity is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016892 name: endoribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "endoribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] xref: EC:3.1.27 is_a: GO:0004521 ! endoribonuclease activity is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: GO:0016893 name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok synonym: "5'-endonuclease activity" EXACT [] synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" RELATED [] xref: EC:3.1.30 is_a: GO:0004519 ! endonuclease activity [Term] id: GO:0016894 name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok synonym: "3'-endonuclease activity" EXACT [] synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED [] xref: EC:3.1.31 is_a: GO:0004519 ! endonuclease activity [Term] id: GO:0016895 name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function alt_id: GO:0008858 def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] synonym: "exonuclease VIII activity" NARROW [] xref: EC:3.1.11 is_a: GO:0004529 ! exodeoxyribonuclease activity is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016896 name: exoribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.13 xref: Reactome:3226 "exoribonuclease activity, producing 5'-phosphomonoesters" is_a: GO:0004532 ! exoribonuclease activity is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016897 name: exoribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai] xref: EC:3.1.14 is_a: GO:0004532 ! exoribonuclease activity is_a: GO:0016797 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: GO:0016898 name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.1.2 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016899 name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.1.3 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016900 name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:ai] synonym: "oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor" EXACT [] xref: EC:1.1.4 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016901 name: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.1.5 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016902 name: oxidoreductase activity, acting on the CH-OH group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0016614 [Term] id: GO:0016903 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.2.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW [] xref: EC:1.2 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016905 name: myosin heavy chain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] synonym: "ATP:myosin heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] synonym: "ATP:myosin-heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] synonym: "calmodulin-dependent myosin heavy chain kinase activity" EXACT [EC:2.7.11.7] synonym: "MHCK" RELATED [EC:2.7.11.7] synonym: "MIHC kinase activity" EXACT [EC:2.7.11.7] synonym: "myosin heavy chain kinase A activity" EXACT [EC:2.7.11.7] synonym: "myosin heavy-chain kinase activity" EXACT [EC:2.7.11.7] synonym: "myosin I heavy-chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin-heavy-chain kinase activity" EXACT [EC:2.7.11.7] synonym: "STK6" RELATED [EC:2.7.11.7] xref: EC:2.7.11.7 is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0016906 name: sterol 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173] synonym: "sterol 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "sterol glucosyltransferase activity" EXACT [] synonym: "sterol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "sterol:UDPG glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-sterol beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose:sterol glucosyltransferase activity" EXACT [] synonym: "UDPG-SGTase activity" EXACT [EC:2.4.1.173] synonym: "UDPG:sterol glucosyltransferase activity" EXACT [] synonym: "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "uridine diphosphoglucose-poriferasterol glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "uridine diphosphoglucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] xref: EC:2.4.1.173 xref: MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0016907 name: G-protein coupled acetylcholine receptor activity namespace: molecular_function def: "Combining with acetylcholine to initiate a change in cell activity via activation of a G protein." [GOC:mah] synonym: "G protein coupled acetylcholine receptor activity" EXACT [] synonym: "G-protein-coupled acetylcholine receptor activity" EXACT [] is_a: GO:0008227 ! G-protein coupled amine receptor activity is_a: GO:0015464 ! acetylcholine receptor activity [Term] id: GO:0016909 name: SAP kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines." [GOC:ma] synonym: "SAPK" EXACT [] synonym: "stress-activated kinase activity" EXACT [] synonym: "stress-activated protein kinase activity" EXACT [] xref: EC:2.7.11.- is_a: GO:0004707 ! MAP kinase activity [Term] id: GO:0016910 name: SAP kinase 3 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a gene product. synonym: "SAPK3" EXACT [] is_obsolete: true consider: GO:0004674 consider: GO:0004871 consider: GO:0007254 [Term] id: GO:0016911 name: SAP kinase 4 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a gene product. synonym: "SAPK4" EXACT [] is_obsolete: true consider: GO:0004674 consider: GO:0004871 consider: GO:0007254 [Term] id: GO:0016912 name: SAP kinase 5 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because there are no known gene products that would be described as 'SAP kinase 5', and the term name implies that it refers to a gene product. synonym: "SAPK5" EXACT [] is_obsolete: true consider: GO:0004674 consider: GO:0004871 consider: GO:0007254 [Term] id: GO:0016913 name: follicle-stimulating hormone activity namespace: molecular_function def: "The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis." [ISBN:0198547684] synonym: "follicle stimulating hormone activity" EXACT [] synonym: "follitropin activity" EXACT [ISBN:0198506732] synonym: "FSH activity" EXACT [GOC:mah] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016914 name: follicle-stimulating hormone complex namespace: cellular_component def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684] synonym: "follicle stimulating hormone complex" EXACT [] synonym: "FSH complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part [Term] id: GO:0016915 name: activin namespace: molecular_function def: "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0005160 consider: GO:0046881 [Term] id: GO:0016916 name: inhibin namespace: molecular_function def: "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0005160 consider: GO:0046882 [Term] id: GO:0016917 name: GABA receptor activity namespace: molecular_function def: "Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity." [GOC:jl, PMID:10637650] comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'. synonym: "4-aminobutanoate receptor activity" EXACT [] synonym: "4-aminobutyrate receptor activity" EXACT [] synonym: "GABA binding" EXACT [] synonym: "gamma-aminobutyrate binding" EXACT [] synonym: "gamma-aminobutyric acid binding" EXACT [] synonym: "gamma-aminobutyric acid receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0016918 name: retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [CHEBI:15035, GOC:curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "blue-sensitive opsin" RELATED [] synonym: "green-sensitive opsin" RELATED [] synonym: "long-wave-sensitive opsin" RELATED [] synonym: "opsin" RELATED [] synonym: "red-sensitive opsin" RELATED [] synonym: "retinaldehyde binding" EXACT [] synonym: "short-wave-sensitive opsin" RELATED [] synonym: "UV-sensitive opsin" RELATED [] synonym: "violet-sensitive opsin" RELATED [] synonym: "vitamin A binding" BROAD [] is_a: GO:0005501 ! retinoid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0016919 name: nardilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [EC:3.4.24.61] comment: This term was made obsolete because it represents a gene product. synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61] synonym: "NRD convertase activity" EXACT [EC:3.4.24.61] synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61] xref: EC:3.4.24.61 xref: MetaCyc:3.4.24.61-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0016920 name: pyroglutamyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah] subset: gosubset_prok xref: EC:3.4.19.- is_a: GO:0008242 ! omega peptidase activity [Term] id: GO:0016921 name: pyroglutamyl-peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6] comment: This term was made obsolete because it represents a gene product. synonym: "PAP-II activity" EXACT [EC:3.4.19.6] synonym: "pyroglutamate aminopeptidase II" RELATED [EC:3.4.19.6] synonym: "pyroglutamyl aminopeptidase II activity" EXACT [EC:3.4.19.6] synonym: "pyroglutamyl peptidase II" RELATED [EC:3.4.19.6] synonym: "thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "thyroliberinase activity" NARROW [EC:3.4.19.6] synonym: "thyrotropin-releasing factor pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone degrading ectoenzyme activity" NARROW [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone-degrading peptidase activity" EXACT [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "TRH-DE activity" NARROW [EC:3.4.19.6] synonym: "TRH-degrading ectoenzyme activity" NARROW [EC:3.4.19.6] synonym: "TRH-specific aminopeptidase activity" NARROW [EC:3.4.19.6] xref: EC:3.4.19.6 xref: MetaCyc:3.4.19.6-RXN is_obsolete: true replaced_by: GO:0008237 replaced_by: GO:0016920 [Term] id: GO:0016922 name: ligand-dependent nuclear receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974] synonym: "ligand-dependent nuclear receptor interactor activity" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0016923 name: ligand-dependent thyroid hormone receptor interactor activity namespace: molecular_function def: "OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor." [PMID:7776974] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "TRIP4" RELATED [] is_obsolete: true consider: GO:0046966 [Term] id: GO:0016925 name: protein sumoylation namespace: biological_process alt_id: GO:0006485 alt_id: GO:0016927 def: "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250] synonym: "protein sumolation" EXACT [] synonym: "small ubiquitin-related protein 1 conjugation" EXACT [] synonym: "SUMO-protein conjugation" EXACT [] synonym: "sumoylation" EXACT [] xref: Wikipedia:SUMO_protein is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0016926 name: protein desumoylation namespace: biological_process alt_id: GO:0016928 def: "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250] synonym: "desumoylation" EXACT [] synonym: "protein desumolation" EXACT [] is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0016929 name: SUMO-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250] synonym: "SUSP" NARROW [] synonym: "ULP" NARROW [] is_a: GO:0019783 ! small conjugating protein-specific protease activity [Term] id: GO:0016933 name: extracellular-glycine-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "glycine receptor" BROAD [] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity [Term] id: GO:0016934 name: extracellular-glycine-gated chloride channel activity namespace: molecular_function alt_id: GO:0004891 def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'receptor activity ; GO:0004872'. synonym: "glycine receptor" BROAD [] synonym: "glycine-inhibited chloride channel activity" RELATED [] xref: Reactome:4242 "extracellular-glycine-gated chloride channel activity" is_a: GO:0005237 ! inhibitory extracellular ligand-gated ion channel activity is_a: GO:0005254 ! chloride channel activity is_a: GO:0016933 ! extracellular-glycine-gated ion channel activity [Term] id: GO:0016935 name: glycine-gated chloride channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034707 ! chloride channel complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0016936 name: galactoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycoside in which the sugar group is galactose." [CHEBI:24163, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0016937 name: short-branched-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue." [GOC:mah] xref: EC:1.3.99.- is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0016938 name: kinesin I complex namespace: cellular_component def: "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0016939 name: kinesin II complex namespace: cellular_component def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0016941 name: natriuretic peptide receptor activity namespace: molecular_function def: "Combining with a natriuretic peptide to initiate a change in cell activity." [GOC:mah] is_a: GO:0001653 ! peptide receptor activity [Term] id: GO:0016942 name: insulin-like growth factor binding protein complex namespace: cellular_component def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl] subset: goslim_pir synonym: "IGF binding protein complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0016943 name: RNA polymerase I transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol I transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0006362 [Term] id: GO:0016944 name: RNA polymerase II transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol II transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0006368 [Term] id: GO:0016945 name: RNA polymerase III transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol III transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0006385 [Term] id: GO:0016946 name: cathepsin F activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.22.41 xref: MetaCyc:3.4.22.41-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0016962 name: receptor-associated protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and not a molecular function. is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0016963 name: alpha-2 macroglobulin receptor-associated protein activity namespace: molecular_function def: "OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains." [GOC:curators] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0016964 name: alpha-2 macroglobulin receptor activity namespace: molecular_function def: "Combining with an alpha-2 macroglobulin to initiate a change in cell activity." [GOC:ma] is_a: GO:0004872 ! receptor activity [Term] id: GO:0016966 name: nitric oxide reductase activity namespace: molecular_function alt_id: GO:0016967 alt_id: GO:0016968 def: "Catalysis of the reaction: nitrous oxide + acceptor + H2O = 2 nitric oxide + reduced acceptor." [EC:1.7.99.7, MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN] subset: gosubset_prok synonym: "CYP55" NARROW [] synonym: "cytochrome bc nitric oxide reductase activity" NARROW [] synonym: "nitric-oxide reductase activity" EXACT [EC:1.7.99.7] synonym: "nitrogen oxide reductase activity" EXACT [EC:1.7.99.7] synonym: "nitrous-oxide:(acceptor) oxidoreductase (NO-forming)" EXACT [EC:1.7.99.7] synonym: "nitrous-oxide:acceptor oxidoreductase (NO-forming)" EXACT [EC:1.7.99.7] synonym: "P450 nitric oxide reductase activity" NARROW [] synonym: "P450nor" NARROW [] xref: EC:1.7.99.7 xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016969 name: hemerythrin namespace: molecular_function def: "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0016970 name: hemocyanin namespace: molecular_function def: "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0016971 name: flavin-linked sulfhydryl oxidase activity namespace: molecular_function def: "Catalysis of the formation of disulfide bridges." [PMID:10899311] is_a: GO:0016972 ! thiol oxidase activity [Term] id: GO:0016972 name: thiol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2] synonym: "sulfhydryl oxidase activity" EXACT [EC:1.8.3.2] synonym: "thiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.2] xref: EC:1.8.3.2 xref: MetaCyc:THIOL-OXIDASE-RXN xref: UM-BBD_reactionID:r1293 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0016973 name: poly(A)+ mRNA export from nucleus namespace: biological_process def: "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai] synonym: "poly(A) mRNA export from nucleus" EXACT [] synonym: "poly(A)+ mRNA export from cell nucleus" EXACT [] synonym: "poly(A)+ mRNA export out of nucleus" EXACT [] synonym: "poly(A)+ mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "poly(A)+ mRNA-nucleus export" EXACT [] is_a: GO:0006406 ! mRNA export from nucleus [Term] id: GO:0016975 name: alpha-2 macroglobulin namespace: molecular_function def: "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004866 [Term] id: GO:0016977 name: chitosanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132] subset: gosubset_prok synonym: "chitosan N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.132] xref: EC:3.2.1.132 xref: MetaCyc:3.2.1.132-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016979 name: lipoate-protein ligase activity namespace: molecular_function alt_id: GO:0008916 alt_id: GO:0016978 def: "Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein." [EC:6.3.4.-] subset: gosubset_prok synonym: "lipoate-protein ligase A activity" NARROW [] synonym: "lipoate-protein ligase B activity" NARROW [] xref: EC:6.3.4.- xref: MetaCyc:RXN-8654 xref: MetaCyc:RXN-8655 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016980 name: creatinase activity namespace: molecular_function def: "Catalysis of the reaction: creatine + H(2)O = sarcosine + urea." [EC:3.5.3.3, RHEA:22459] subset: gosubset_prok synonym: "creatine amidinohydrolase activity" EXACT [EC:3.5.3.3] xref: EC:3.5.3.3 xref: KEGG:R01566 xref: MetaCyc:CREATINASE-RXN xref: RHEA:22459 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0016984 name: ribulose-bisphosphate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate." [EC:4.1.1.39] subset: gosubset_prok synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.39] synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming)" EXACT [EC:4.1.1.39] synonym: "carboxydismutase activity" RELATED [EC:4.1.1.39] synonym: "D-ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "D-ribulose-1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "diphosphoribulose carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-bisphosphate carboxylase/oxygenase activity" EXACT [] synonym: "ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "ribulose bisphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "ribulose diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "rubisco activity" EXACT [] synonym: "RuBisCO activity" EXACT [EC:4.1.1.39] synonym: "RuBP carboxylase activity" EXACT [EC:4.1.1.39] xref: EC:4.1.1.39 xref: MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0016985 name: mannan endo-1,4-beta-mannosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,4-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78] subset: gosubset_prok synonym: "1,4-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "beta-1, 4-mannan 4-mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "beta-D-mannanase activity" EXACT [EC:3.2.1.78] synonym: "beta-mannanase activity" EXACT [EC:3.2.1.78] synonym: "beta-mannanase B" RELATED [EC:3.2.1.78] synonym: "endo-1,4-beta-mannanase activity" EXACT [EC:3.2.1.78] synonym: "endo-1,4-mannanase activity" EXACT [EC:3.2.1.78] synonym: "endo-beta-1,4-mannase activity" EXACT [EC:3.2.1.78] synonym: "endo-beta-mannanase activity" EXACT [EC:3.2.1.78] xref: EC:3.2.1.78 xref: MetaCyc:3.2.1.78-RXN is_a: GO:0004567 ! beta-mannosidase activity [Term] id: GO:0016986 name: transcription initiation factor activity namespace: molecular_function def: "OBSOLETE. Plays a role in regulating transcription initiation." [GOC:curators] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok synonym: "transcriptional initiation factor activity" EXACT [] is_obsolete: true consider: GO:0000988 consider: GO:0000996 consider: GO:0001071 consider: GO:0006352 [Term] id: GO:0016987 name: sigma factor activity namespace: molecular_function def: "A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes." [GOC:krc, GOC:txnOH] subset: gosubset_prok synonym: "sigma transcription factor" RELATED [] is_a: GO:0000996 ! core RNA polymerase binding promoter specificity activity [Term] id: GO:0016988 name: transcription initiation factor antagonist activity namespace: molecular_function def: "OBSOLETE. The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok synonym: "transcriptional initiation factor antagonist activity" EXACT [] is_obsolete: true [Term] id: GO:0016989 name: sigma factor antagonist activity namespace: molecular_function def: "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, GOC:txnOH, Wikipedia:Anti-sigma_factors] subset: gosubset_prok synonym: "anti-sigma factor activity" EXACT [] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0016990 name: arginine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3." [EC:3.5.3.6] subset: gosubset_prok synonym: "arginine dihydrolase activity" EXACT [EC:3.5.3.6] synonym: "citrulline iminase activity" EXACT [EC:3.5.3.6] synonym: "L-arginine deiminase activity" EXACT [EC:3.5.3.6] synonym: "L-arginine iminohydrolase activity" EXACT [EC:3.5.3.6] xref: EC:3.5.3.6 xref: MetaCyc:ARGININE-DEIMINASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0016992 name: lipoate synthase activity namespace: molecular_function alt_id: GO:0017140 def: "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109] subset: gosubset_prok synonym: "LipA" RELATED [EC:2.8.1.8] synonym: "lipoic acid synthase" EXACT [GOC:dph, GOC:tb] synonym: "lipoyl synthase activity" EXACT [EC:2.8.1.8] synonym: "LS" RELATED [EC:2.8.1.8] synonym: "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] xref: EC:2.8.1.8 xref: MetaCyc:RXN0-949 is_a: GO:0016783 ! sulfurtransferase activity is_a: GO:0016979 ! lipoate-protein ligase activity is_a: GO:0070283 ! radical SAM enzyme activity [Term] id: GO:0016993 name: precorrin-8X methylmutase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate." [EC:5.4.1.2] subset: gosubset_prok synonym: "HBA synthase activity" EXACT [EC:5.4.1.2] synonym: "hydrogenobyrinic acid-binding protein activity" NARROW [EC:5.4.1.2] synonym: "precorrin isomerase activity" EXACT [EC:5.4.1.2] synonym: "precorrin-8X 11,12-methylmutase activity" EXACT [EC:5.4.1.2] xref: EC:5.4.1.2 xref: MetaCyc:5.4.1.2-RXN is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0016994 name: precorrin-6A reductase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+." [EC:1.3.1.54] subset: gosubset_prok synonym: "precorrin-6B:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] synonym: "precorrin-6X reductase activity" EXACT [] synonym: "precorrin-6Y:NADP(+) oxidoreductase activity" EXACT [EC:1.3.1.54] synonym: "precorrin-6Y:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] xref: EC:1.3.1.54 xref: MetaCyc:1.3.1.54-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016995 name: cholesterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)." [EC:1.1.3.6, RHEA:21331] synonym: "3beta-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "3beta-hydroxysteroid:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol- O2 oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol-O(2) oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol-O2 oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] xref: EC:1.1.3.6 xref: KEGG:R01459 xref: MetaCyc:CHOLESTEROL-OXIDASE-RXN xref: RHEA:21331 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0016996 name: endo-alpha-sialidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129] synonym: "alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] synonym: "endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endo-N-acylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endoneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endosialidase activity" EXACT [EC:3.2.1.129] synonym: "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] synonym: "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "polysialoside (2->8)-alpha-sialosylhydrolase activity" EXACT [EC:3.2.1.129] xref: EC:3.2.1.129 xref: MetaCyc:3.2.1.129-RXN is_a: GO:0016997 ! alpha-sialidase activity [Term] id: GO:0016997 name: alpha-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah] subset: gosubset_prok is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016998 name: cell wall macromolecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] subset: gosubset_prok synonym: "cell wall breakdown" RELATED [GOC:mah] synonym: "cell wall catabolism" RELATED [GOC:mah] synonym: "cell wall degradation" RELATED [GOC:mah] is_a: GO:0009056 ! catabolic process is_a: GO:0044036 ! cell wall macromolecule metabolic process [Term] id: GO:0016999 name: antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] subset: gosubset_prok synonym: "antibiotic metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0017000 name: antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] subset: gosubset_prok synonym: "antibiotic anabolism" EXACT [] synonym: "antibiotic biosynthesis" EXACT [] synonym: "antibiotic formation" EXACT [] synonym: "antibiotic synthesis" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0017001 name: antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] subset: gosubset_prok synonym: "antibiotic breakdown" EXACT [] synonym: "antibiotic catabolism" EXACT [] synonym: "antibiotic degradation" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0017002 name: activin receptor activity namespace: molecular_function def: "Combining with activin, one of two gonadal glycoproteins related to transforming growth factor beta, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity [Term] id: GO:0017003 name: protein-heme linkage namespace: biological_process def: "The covalent linkage of heme and a protein." [GOC:ma] subset: gosubset_prok synonym: "protein-haem linkage" EXACT [] is_a: GO:0017006 ! protein-tetrapyrrole linkage [Term] id: GO:0017004 name: cytochrome complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah] subset: gosubset_prok synonym: "cytochrome biogenesis" BROAD [] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0017005 name: 3'-tyrosyl-DNA phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265] comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity [Term] id: GO:0017006 name: protein-tetrapyrrole linkage namespace: biological_process def: "The covalent linking of a tetrapyrrole to a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0006464 ! protein modification process [Term] id: GO:0017007 name: protein-bilin linkage namespace: biological_process def: "The covalent linkage of bilin and a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0017006 ! protein-tetrapyrrole linkage [Term] id: GO:0017008 name: protein-phycobiliviolin linkage namespace: biological_process def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin." [RESID:AA0258] subset: gosubset_prok xref: RESID:AA0258 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017009 name: protein-phycocyanobilin linkage namespace: biological_process def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin." [RESID:AA0131] subset: gosubset_prok xref: RESID:AA0131 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017010 name: protein-phycourobilin linkage namespace: biological_process def: "The linkage of the chromophore phycourobilin to phycoerythrins." [RESID:AA0260] subset: gosubset_prok xref: RESID:AA0260 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017011 name: protein-phycoerythrobilin linkage namespace: biological_process def: "The linkage of the chromophore phycoerythrobilin to phycoerythrins." [RESID:AA0132, RESID:AA0259] subset: gosubset_prok xref: RESID:AA0132 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017012 name: protein-phytochromobilin linkage namespace: biological_process def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin." [RESID:AA0133] subset: gosubset_prok xref: RESID:AA0133 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017013 name: protein flavinylation namespace: biological_process def: "The addition of a flavin group to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid flavinylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0017014 name: protein nitrosylation namespace: biological_process def: "The covalent addition of a nitric oxide group to an amino acid within a protein." [GOC:ai, PMID:20972426] subset: gosubset_prok synonym: "protein amino acid nitrosylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0017015 name: regulation of transforming growth factor beta receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] synonym: "regulation of TGF-beta receptor signaling pathway" EXACT [] synonym: "regulation of TGFbeta receptor signaling pathway" EXACT [] synonym: "regulation of transforming growth factor beta receptor signalling pathway" EXACT [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0017016 name: Ras GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Ras interactor activity" RELATED [] is_a: GO:0031267 ! small GTPase binding [Term] id: GO:0017017 name: MAP kinase tyrosine/serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] synonym: "dual-specificity MAP kinase phosphatase activity" EXACT [] xref: EC:3.1.3.- is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity is_a: GO:0033549 ! MAP kinase phosphatase activity [Term] id: GO:0017018 name: myosin phosphatase activity namespace: molecular_function alt_id: GO:0017019 def: "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] synonym: "myosin phosphatase myosin binding" RELATED [] synonym: "myosin phosphatase, intrinsic catalyst activity" EXACT [] xref: Reactome:25096 "myosin phosphatase activity" is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0017020 name: myosin phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme myosin phosphatase." [EC:3.1.3.16, GOC:ai] synonym: "myosin phosphatase, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0017021 name: myosin phosphatase myosin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes the binding of myosin phosphatase to myosin, which is not a molecular function. is_obsolete: true consider: GO:0017018 consider: GO:0017022 [Term] id: GO:0017022 name: myosin binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] synonym: "myosin phosphatase myosin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0017023 name: myosin phosphatase complex namespace: cellular_component def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin." [EC:3.1.3.16] is_a: GO:0008287 ! protein serine/threonine phosphatase complex [Term] id: GO:0017024 name: myosin I binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0017025 name: TBP-class protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867] synonym: "TATA-binding protein binding" NARROW [] synonym: "TBP binding" NARROW [] synonym: "TBP-related factor (TRF) protein binding" NARROW [] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0017026 name: procollagen C-endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [EC:3.4.24.19] comment: This term was made obsolete because it represents a gene product. synonym: "BMP1" NARROW [] synonym: "carboxyprocollagen peptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-terminal peptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19] xref: EC:3.4.24.19 xref: MetaCyc:3.4.24.19-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0017027 name: transmembrane receptor protein serine/threonine kinase receptor-associated protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0017028 name: protein stabilization activity namespace: molecular_function def: "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds." [GOC:jid, http://biotech.icmb.utexas.edu] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0050821 [Term] id: GO:0017029 name: lysosomal protein stabilization namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0005764 consider: GO:0050821 [Term] id: GO:0017030 name: beta-galactosidase stabilization activity namespace: molecular_function def: "OBSOLETE. Stabilization of the structure of beta-galactosidase." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0050821 [Term] id: GO:0017032 name: potassium:amino acid symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai] synonym: "potassium:amino acid transporter activity" BROAD [] is_a: GO:0005416 ! cation:amino acid symporter activity is_a: GO:0022820 ! potassium ion symporter activity [Term] id: GO:0017033 name: DNA topoisomerase I binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme DNA topoisomerase I." [GOC:ai] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0017034 name: Rap guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0017038 name: protein import namespace: biological_process def: "The directed movement of proteins into a cell or organelle." [GOC:ai] subset: gosubset_prok synonym: "protein uptake" EXACT [] is_a: GO:0015031 ! protein transport [Term] id: GO:0017039 name: dipeptidyl-peptidase III activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "dipeptidyl aminopeptidase III activity" EXACT [EC:3.4.14.4] synonym: "dipeptidyl arylamidase III activity" EXACT [EC:3.4.14.4] synonym: "DPP III activity" EXACT [EC:3.4.14.4] synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4] synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4] xref: EC:3.4.14.4 xref: MetaCyc:3.4.14.4-RXN is_obsolete: true replaced_by: GO:0008239 [Term] id: GO:0017040 name: ceramidase activity namespace: molecular_function def: "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23] subset: gosubset_prok synonym: "acylsphingosine deacylase activity" EXACT [EC:3.5.1.23] synonym: "glycosphingolipid ceramide deacylase" BROAD [EC:3.5.1.23] synonym: "N-acylsphingosine amidohydrolase activity" EXACT [EC:3.5.1.23] xref: EC:3.5.1.23 xref: MetaCyc:CERAMIDASE-RXN xref: Reactome:10445 "ceramidase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0017041 name: galactosylgalactosylglucosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47] synonym: "ceramide trihexosidase activity" EXACT [EC:3.2.1.47] synonym: "ceramidetrihexosidase activity" EXACT [EC:3.2.1.47] synonym: "ceramidetrihexoside alpha-galactosidase activity" EXACT [EC:3.2.1.47] synonym: "D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.47] synonym: "trihexosyl ceramide galactosidase activity" EXACT [EC:3.2.1.47] synonym: "trihexosylceramide alpha-galactosidase activity" EXACT [EC:3.2.1.47] xref: EC:3.2.1.47 xref: MetaCyc:3.2.1.47-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! ceramidase activity [Term] id: GO:0017042 name: glycosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [EC:3.2.1.62] synonym: "cerebrosidase activity" EXACT [EC:3.2.1.62] synonym: "glycosyl ceramide glycosylhydrolase activity" EXACT [EC:3.2.1.62] synonym: "glycosyl-N-acylsphingosine glycohydrolase activity" EXACT [EC:3.2.1.62] synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.2.1.62] synonym: "phloretin-glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phloridzin beta-glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phloridzin glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phlorizin hydrolase activity" EXACT [EC:3.2.1.62] xref: EC:3.2.1.62 xref: MetaCyc:GLYCOSYLCERAMIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! ceramidase activity [Term] id: GO:0017043 name: adrenocorticotropin namespace: molecular_function def: "OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. synonym: "corticotropin" BROAD [] is_obsolete: true consider: GO:0005102 consider: GO:0046886 consider: GO:0046887 [Term] id: GO:0017044 name: melanocyte-stimulating hormone activity namespace: molecular_function def: "The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "alpha-melanocyte stimulating hormone activity" NARROW [ISBN:0198506732] synonym: "alpha-melanophore stimulating hormone activity" NARROW [ISBN:0198506732] synonym: "melanocyte stimulating hormone activity" EXACT [] is_a: GO:0005179 ! hormone activity [Term] id: GO:0017045 name: corticotropin-releasing hormone activity namespace: molecular_function def: "The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary." [ISBN:0198506732] synonym: "adrenocorticotropin-releasing hormone" EXACT [] xref: Wikipedia:Corticotropin-releasing_hormone is_a: GO:0005179 ! hormone activity [Term] id: GO:0017046 name: peptide hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with any peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "polypeptide hormone binding" EXACT [] is_a: GO:0042277 ! peptide binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0017048 name: Rho GTPase binding namespace: molecular_function alt_id: GO:0017031 def: "Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856] synonym: "Rho interactor activity" RELATED [] synonym: "Rhophilin" NARROW [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0017049 name: GTP-Rho binding namespace: molecular_function def: "Interacting selectively and non-covalently with the GTP-bound form of the Rho protein." [GOC:mah] is_a: GO:0017048 ! Rho GTPase binding [Term] id: GO:0017050 name: D-erythro-sphingosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [MetaCyc:RXN3DJ-11417] synonym: "sphingosine kinase activity" EXACT [] xref: MetaCyc:RXN3DJ-11417 xref: Reactome:25153 "D-erythro-sphingosine kinase activity" is_a: GO:0016301 ! kinase activity [Term] id: GO:0017051 name: retinol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081] is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0017052 name: insulin-like growth factor binding protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0016942 [Term] id: GO:0017053 name: transcriptional repressor complex namespace: cellular_component def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0017054 name: negative cofactor 2 complex namespace: cellular_component def: "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413] is_a: GO:0017053 ! transcriptional repressor complex [Term] id: GO:0017055 name: negative regulation of RNA polymerase II transcriptional preinitiation complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] synonym: "down regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "down-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "downregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "inhibition of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] synonym: "negative regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT [] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0045898 ! regulation of RNA polymerase II transcriptional preinitiation complex assembly is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly [Term] id: GO:0017056 name: structural constituent of nuclear pore namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0017057 name: 6-phosphogluconolactonase activity namespace: molecular_function def: "Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [EC:3.1.1.31, RHEA:12559] subset: gosubset_prok synonym: "6-PGL" RELATED [EC:3.1.1.31] synonym: "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.31] synonym: "phosphogluconolactonase activity" EXACT [EC:3.1.1.31] xref: EC:3.1.1.31 xref: KEGG:R02035 xref: MetaCyc:6PGLUCONOLACT-RXN xref: Reactome:25159 "6-phosphogluconolactonase activity" xref: RHEA:12559 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0017058 name: FH1 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0017059 name: serine C-palmitoyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50] is_a: GO:0031211 ! endoplasmic reticulum palmitoyltransferase complex [Term] id: GO:0017060 name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65] synonym: "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "(Lea)-dependent (alpha-3/4)-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "alpha(1,3/1,4) fucosyltransferase III" RELATED [EC:2.4.1.65] synonym: "alpha(1,4)-L-fucosyltransferase activity" EXACT [] synonym: "alpha-(1,3/1,4) fucosyltransferase III activity" EXACT [EC:2.4.1.65] synonym: "alpha-(1->4)-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "alpha-4-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "beta-acetylglucosaminylsaccharide fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "blood group Lewis alpha-4-fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "blood group Lewis alpha-4-fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "blood-group substance Le(a)-dependent fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "blood-group substance Lea-dependent fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "FucT-II activity" EXACT [EC:2.4.1.65] synonym: "galactoside 3(4)-L-fucosyltransferase activity" EXACT [] synonym: "GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "Lewis alpha-(1->3/4)-fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "Lewis alpha-(1->3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65] synonym: "Lewis FT activity" NARROW [EC:2.4.1.65] synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase" NARROW [EC:2.4.1.65] synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity" NARROW [EC:2.4.1.65] xref: EC:2.4.1.65 xref: MetaCyc:2.4.1.65-RXN is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0017061 name: S-methyl-5-thioadenosine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28] subset: gosubset_prok synonym: "5'-deoxy-5'-methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "5'-methylthioadenosine phosphorylase activity" EXACT [] synonym: "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] synonym: "MeSAdo phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MeSAdo/Ado phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "methylthioadenosine nucleoside phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MTA phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MTAPase activity" EXACT [EC:2.4.2.28] synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] xref: EC:2.4.2.28 xref: MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0017062 name: respiratory chain complex III assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents." [GOC:jl, http://www.brainyencyclopedia.com/] subset: gosubset_prok synonym: "coenzyme Q and cytochrome c reductase complex assembly" EXACT [] synonym: "coenzyme Q and cytochrome c reductase complex biogenesis" EXACT [] synonym: "complex III assembly" EXACT [] synonym: "complex III biogenesis" EXACT [] synonym: "cytochrome bc(1) complex assembly" EXACT [GOC:mcc] synonym: "cytochrome bc(1) complex biogenesis" EXACT [] is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0017063 name: phosphatidylserine-specific phospholipase A1 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.32] is_a: GO:0008970 ! phospholipase A1 activity [Term] id: GO:0017064 name: fatty acid amide hydrolase activity namespace: molecular_function alt_id: GO:0017073 def: "Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid." [PMID:15952893] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0017065 name: single-strand selective uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623] synonym: "single-strand selective monofunctional uracil-DNA glycosylase activity" EXACT [] xref: EC:3.2.2.- xref: Reactome:25182 "single-strand selective uracil DNA N-glycosylase activity" is_a: GO:0004844 ! uracil DNA N-glycosylase activity [Term] id: GO:0017067 name: tyrosine-ester sulfotransferase activity namespace: molecular_function alt_id: GO:0008128 def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.9, RHEA:19980] synonym: "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity" EXACT [EC:2.8.2.9] synonym: "aryl sulfotransferase IV" RELATED [EC:2.8.2.9] synonym: "L-tyrosine methyl ester sulfotransferase activity" EXACT [EC:2.8.2.9] synonym: "tyrosine-ester sulphotransferase activity" EXACT [] xref: EC:2.8.2.9 xref: KEGG:R04213 xref: MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN xref: RHEA:19980 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0017069 name: snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small nuclear RNA (snRNA)." [GOC:mah] synonym: "small nuclear RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0017070 name: U6 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). is_a: GO:0017069 ! snRNA binding [Term] id: GO:0017071 name: intracellular cyclic nucleotide activated cation channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034703 ! cation channel complex [Term] id: GO:0017072 name: tubulin-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function." [GOC:jl, PMID:11847227] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. is_obsolete: true consider: GO:0006461 consider: GO:0007021 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0017074 name: procollagen N-endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [EC:3.4.24.14] comment: This term was made obsolete because it represents a gene product. synonym: "aminoprocollagen peptidase activity" EXACT [EC:3.4.24.14] synonym: "aminoterminal procollagen peptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen aminopeptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen aminoterminal protease activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-proteinase activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14] synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14] synonym: "type III procollagen" RELATED [EC:3.4.24.14] xref: EC:3.4.24.14 xref: MetaCyc:3.4.24.14-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0017075 name: syntaxin-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-1." [GOC:ai] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0017076 name: purine nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] subset: gosubset_prok is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0017077 name: oxidative phosphorylation uncoupler activity namespace: molecular_function alt_id: GO:0015302 def: "Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945] synonym: "mitochondrial uncoupling protein activity" NARROW [] synonym: "uncoupling protein activity" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0017078 name: Hsc70 protein regulator activity namespace: molecular_function def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70 protein activity'. synonym: "Hsc70 interacting protein" BROAD [] is_obsolete: true replaced_by: GO:0031072 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0017080 name: sodium channel regulator activity namespace: molecular_function def: "Modulates the activity of a sodium channel." [GOC:mah] is_a: GO:0016247 ! channel regulator activity [Term] id: GO:0017081 name: chloride channel regulator activity namespace: molecular_function def: "Modulates the activity of a chloride channel." [GOC:mah] xref: Reactome:14588 "chloride channel regulator activity" is_a: GO:0016247 ! channel regulator activity [Term] id: GO:0017082 name: mineralocorticoid receptor activity namespace: molecular_function def: "Combining with mineralocorticoid to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0003707 ! steroid hormone receptor activity [Term] id: GO:0017083 name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152] synonym: "galactoside 3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "galactoside 3-L-fucosyltransferase activity" EXACT [] synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "lewis-negative alpha-3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "Lewis-negative alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] synonym: "plasma alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] xref: EC:2.4.1.152 xref: MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN is_a: GO:0046920 ! alpha(1,3)-fucosyltransferase activity [Term] id: GO:0017084 name: delta1-pyrroline-5-carboxylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI] synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT [] xref: Reactome:25214 "delta1-pyrroline-5-carboxylate synthetase activity" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0017085 name: response to insecticide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] subset: gosubset_prok synonym: "insecticide resistance" RELATED [] synonym: "insecticide susceptibility/resistance" RELATED [] is_a: GO:0009636 ! response to toxin [Term] id: GO:0017086 name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex namespace: cellular_component alt_id: GO:0031212 def: "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4] synonym: "BCADH" EXACT [] synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0017087 name: mitochondrial processing peptidase complex namespace: cellular_component def: "A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [BRENDA:3.4.24.64, EC:3.4.24.64, GOC:mah] comment: Note that monomeric mitochondrial processing peptidases have been observed. is_a: GO:0043234 ! protein complex is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0017088 name: X-Pro dipeptidyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "PepX" RELATED [EC:3.4.14.11] synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11] synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11] synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT [] xref: EC:3.4.14.11 xref: MetaCyc:3.4.14.11-RXN is_obsolete: true replaced_by: GO:0008239 [Term] id: GO:0017089 name: glycolipid transporter activity namespace: molecular_function def: "Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells." [GOC:ai] is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0017090 name: meprin A complex namespace: cellular_component def: "A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18, GOC:mah, MEROPS_fam:M12] synonym: "PABA peptide hydrolase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0016021 ! integral to membrane [Term] id: GO:0017091 name: AU-rich element binding namespace: molecular_function def: "Interacting selectively and non-covalently with AU-rich elements within the 3' untranslated region of mRNAs." [GOC:mah, PMID:7892223] synonym: "ARE binding" EXACT [] synonym: "AU-specific RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0017092 name: sterol regulatory element-binding protein site 2 protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525] comment: This term was made obsolete because it represents a gene product. synonym: "SREBP site 2 protease activity" EXACT [] is_obsolete: true replaced_by: GO:0008237 [Term] id: GO:0017093 name: sterol regulatory element-binding protein protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] comment: This term was made obsolete because it represents a gene product. synonym: "SREBP protease activity" EXACT [] is_obsolete: true replaced_by: GO:0070011 [Term] id: GO:0017094 name: sterol regulatory element-binding protein site 1 protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525] comment: This term was made obsolete because it represents a gene product. synonym: "SREBP site 1 protease activity" EXACT [] is_obsolete: true replaced_by: GO:0008236 [Term] id: GO:0017095 name: heparan sulfate 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808] synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT [] synonym: "heparin 6-O-sulfotransferase activity" RELATED [] xref: EC:2.8.2.- is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0017096 name: acetylserotonin O-methyltransferase activity namespace: molecular_function alt_id: GO:0017097 def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine." [EC:2.1.1.4] subset: gosubset_prok synonym: "acetylserotonin methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "acetylserotonin N-methyltransferase activity" RELATED [KEGG_ENZYME:2.1.1.4] synonym: "hydroxyindole methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "hydroxyindole O-methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] xref: EC:2.1.1.4 xref: MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0017098 name: sulfonylurea receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023] synonym: "sulfonylurea receptor ligand" NARROW [] synonym: "sulphonylurea receptor binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0017099 name: very long-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long-chain fatty acid residue." [GOC:mah] synonym: "very-long-chain-acyl-CoA dehydrogenase activity" EXACT [] xref: EC:1.3.99.- xref: Reactome:25241 "very long-chain-acyl-CoA dehydrogenase activity" is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0017101 name: aminoacyl-tRNA synthetase multienzyme complex namespace: cellular_component def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847] synonym: "aminoacyl-tRNA synthetase complex" EXACT [] synonym: "multisynthetase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0017102 name: methionyl glutamyl tRNA synthetase complex namespace: cellular_component def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0017103 name: UTP:galactose-1-phosphate uridylyltransferase activity namespace: molecular_function alt_id: GO:0003982 def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose." [EC:2.7.7.10, RHEA:14212] synonym: "alpha-D-galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.10] synonym: "galactose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.10] synonym: "galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.10] synonym: "UDPgalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "uridine diphosphate galactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "uridine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "UTP-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "UTP:hexose-1-phosphate uridylyltransferase activity" BROAD [] xref: EC:2.7.7.10 xref: KEGG:R00502 xref: MetaCyc:UTPHEXPURIDYLYLTRANS-RXN xref: RHEA:14212 is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0017105 name: acyl-CoA delta11-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta11-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.5] synonym: "acyl-CoA D11-desaturase activity" EXACT [] synonym: "acyl-CoA delta(11)-desaturase activity" EXACT [] xref: EC:1.14.19.5 is_a: GO:0016215 ! CoA desaturase activity [Term] id: GO:0017106 name: activin inhibitor activity namespace: molecular_function def: "OBSOLETE. Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] comment: This term was made obsolete because it refers to an obsolete molecular function term, 'activin'. is_obsolete: true consider: GO:0004871 [Term] id: GO:0017107 name: anion exchanger adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0017108 name: 5'-flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254] synonym: "5' flap endonuclease activity" EXACT [] xref: Reactome:25632 "5'-flap endonuclease activity" is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters is_a: GO:0048256 ! flap endonuclease activity [Term] id: GO:0017109 name: glutamate-cysteine ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2] synonym: "gamma-glutamylcysteine synthetase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0017110 name: nucleoside-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6] synonym: "apyrase activity" BROAD [] synonym: "CDPase" NARROW [EC:3.6.1.6] synonym: "IDPase" NARROW [EC:3.6.1.6] synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6] synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6] synonym: "NDPase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphatase activity" EXACT [] synonym: "nucleoside diphosphate phosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6] synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6] xref: EC:3.6.1.6 xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0017111 name: nucleoside-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] subset: gosubset_prok synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" EXACT [] synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0017112 name: Rab guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0017113 name: dihydropyrimidine dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2] subset: gosubset_prok synonym: "4,5-dihydrothymine: oxidoreductase activity" EXACT [EC:1.3.1.2] synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.2] synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.2] synonym: "DHPDH" RELATED [EC:1.3.1.2] synonym: "DHU dehydrogenase activity" EXACT [EC:1.3.1.2] synonym: "dihydropyrimidine dehydrogenase activity" EXACT [] synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2] synonym: "dihydrouracil dehydrogenase (NADP)" EXACT [EC:1.3.1.2] synonym: "dihydrouracil dehydrogenase (NADP+) activity" EXACT [EC:1.3.1.2] synonym: "DPD" RELATED [EC:1.3.1.2] synonym: "hydropyrimidine dehydrogenase activity" EXACT [EC:1.3.1.2] xref: EC:1.3.1.2 xref: MetaCyc:1.3.1.2-RXN xref: Reactome:25636 "dihydropyrimidine dehydrogenase (NADP+) activity" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0017114 name: wide-spectrum protease inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of a protease by a wide-spectrum protease inhibitor. A wide-spectrum protease inhibitor is a protein having a peptide stretch which contains specific cleavage sites for different proteinases enabling inhibition of all four classes of proteinases by formation of a covalent bond between the inhibitor and the protease." [GOC:dph, GOC:tb] comment: This term was made obsolete because it represents a regulator of non-existent molecular function. synonym: "wide-spectrum proteinase inhibitor" EXACT [] is_obsolete: true replaced_by: GO:0030414 [Term] id: GO:0017116 name: single-stranded DNA-dependent ATP-dependent DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [EC:3.6.1.3, GOC:jl] synonym: "ssDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:mah] is_a: GO:0004003 ! ATP-dependent DNA helicase activity is_a: GO:0043142 ! single-stranded DNA-dependent ATPase activity [Term] id: GO:0017117 name: single-stranded DNA-dependent ATP-dependent DNA helicase complex namespace: cellular_component def: "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity." [GOC:mah] synonym: "ssDNA-dependent ATP-dependent DNA helicase complex" EXACT [GOC:mah] is_a: GO:0033202 ! DNA helicase complex [Term] id: GO:0017118 name: lipoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme." [PMID:10103005] subset: gosubset_prok is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0017119 name: Golgi transport complex namespace: cellular_component def: "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665] synonym: "COG complex" EXACT [] synonym: "conserved oligomeric Golgi complex" EXACT [] synonym: "Sec34/35 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0017120 name: polyphosphatidylinositol phosphatase activity namespace: molecular_function def: "Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048] synonym: "polyphosphoinositide phosphatase activity" EXACT [GOC:curators] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0017121 name: phospholipid scrambling namespace: biological_process def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE)." [PMID:20043909, PMID:20302864] comment: Note that this term describes the transbilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'. synonym: "PL scrambling" EXACT [] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0097035 ! regulation of membrane lipid distribution [Term] id: GO:0017122 name: protein N-acetylglucosaminyltransferase complex namespace: cellular_component def: "Heterotrimeric enzyme complex, which in humans is composed of two large subunits of the same size, and one smaller subunit. Functions in the addition of nucleotide-activated sugars onto the polypeptide." [PMID:15247246] synonym: "O-GlcNAc transferase complex" EXACT [GOC:mah] synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0017123 name: Ral GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Ral family." [GOC:mah] synonym: "Ral GAP activity" EXACT [GOC:pg] is_a: GO:0005099 ! Ras GTPase activator activity [Term] id: GO:0017124 name: SH3 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0017125 name: deoxycytidyl transferase activity namespace: molecular_function alt_id: GO:0019986 def: "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901] synonym: "deoxycytidyl transferase activity, template-dependent" NARROW [] is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0017126 name: nucleologenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "nucleolus assembly" NARROW [GOC:mah] synonym: "nucleolus biogenesis" EXACT [] is_a: GO:0007000 ! nucleolus organization is_a: GO:0071843 ! cellular component biogenesis at cellular level [Term] id: GO:0017127 name: cholesterol transporter activity namespace: molecular_function def: "Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] xref: Reactome:25647 "cholesterol transporter activity" is_a: GO:0015248 ! sterol transporter activity [Term] id: GO:0017128 name: phospholipid scramblase activity namespace: molecular_function def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [PMID:20043909, PMID:20302864] is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0017129 name: triglyceride binding namespace: molecular_function def: "Interacting selectively and non-covalently with any triester of glycerol." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "triacylglycerol binding" EXACT [GOC:mah] is_a: GO:0008289 ! lipid binding [Term] id: GO:0017130 name: poly(C) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of cytosine residues in an RNA molecule." [GOC:mah] synonym: "poly(C) binding" BROAD [GOC:mah] synonym: "poly(rC) binding" EXACT [GOC:mah] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0017131 name: uridine-rich cytoplasmic polyadenylylation element binding namespace: molecular_function def: "Interacting selectively and non-covalently with U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation." [GOC:krc, PMID:7954828] synonym: "U-rich CPE binding" EXACT [PMID:7954828] synonym: "uridine-rich cytoplasmic polyadenylation element binding" EXACT [] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0017132 name: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase; dependent on the presence of a cyclic nucleotide." [GOC:mah, PMID:9856955] is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0017133 name: mitochondrial electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0044429 ! mitochondrial part is_a: GO:0045251 ! electron transfer flavoprotein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0017134 name: fibroblast growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with fibroblast growth factor." [PMID:9806903] synonym: "FGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0017135 name: membrane-associated protein with guanylate kinase activity interacting namespace: molecular_function def: "OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity." [PMID:10207005] comment: This term was made obsolete because it does not represent a molecular function and the term name appears to make no sense. is_obsolete: true consider: GO:0019899 [Term] id: GO:0017136 name: NAD-dependent histone deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, EC:3.5.1.98, RHEA:24551] synonym: "SIR2" RELATED [] is_a: GO:0004407 ! histone deacetylase activity is_a: GO:0034979 ! NAD-dependent protein deacetylase activity [Term] id: GO:0017137 name: Rab GTPase binding namespace: molecular_function alt_id: GO:0005084 def: "Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Rab escort protein activity" NARROW [] synonym: "Rab interactor activity" RELATED [] synonym: "REP" NARROW [] is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0017139 name: arsenate sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046685 [Term] id: GO:0017141 name: antibiotic susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046677 [Term] id: GO:0017142 name: toxin susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0009636 [Term] id: GO:0017143 name: insecticide metabolic process namespace: biological_process alt_id: GO:0017138 def: "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai] subset: gosubset_prok synonym: "insecticide metabolism" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0009404 ! toxin metabolic process relationship: part_of GO:0017085 ! response to insecticide [Term] id: GO:0017144 name: drug metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2] subset: goslim_pir subset: gosubset_prok synonym: "drug metabolism" EXACT [] xref: Reactome:1229974 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:1257757 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:1283356 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:1303789 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:1331267 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:1356206 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:1377217 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:1397401 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:1423453 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Wikipedia:Drug_metabolism is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0017145 name: stem cell division namespace: biological_process def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] synonym: "stem cell renewal" EXACT [] is_a: GO:0051301 ! cell division [Term] id: GO:0017146 name: N-methyl-D-aspartate selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] synonym: "NMDA-selective glutamate receptor" EXACT [] is_a: GO:0008328 ! ionotropic glutamate receptor complex [Term] id: GO:0017147 name: Wnt-protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] is_a: GO:0005515 ! protein binding [Term] id: GO:0017148 name: negative regulation of translation namespace: biological_process alt_id: GO:0016478 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] subset: gosubset_prok synonym: "down regulation of protein biosynthetic process" EXACT [] synonym: "down-regulation of protein biosynthetic process" EXACT [] synonym: "downregulation of protein biosynthetic process" EXACT [] synonym: "inhibition of protein biosynthetic process" NARROW [] synonym: "negative regulation of protein anabolism" EXACT [] synonym: "negative regulation of protein biosynthesis" EXACT [] synonym: "negative regulation of protein biosynthetic process" EXACT [] synonym: "negative regulation of protein formation" EXACT [] synonym: "negative regulation of protein synthesis" EXACT [] synonym: "protein biosynthesis inhibitor activity" RELATED [] synonym: "protein biosynthetic process inhibitor activity" RELATED [] is_a: GO:0006417 ! regulation of translation is_a: GO:0032269 ! negative regulation of cellular protein metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0006412 ! translation [Term] id: GO:0017149 name: protein biosynthetic process inhibitor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents involvement in a biological process. synonym: "protein anabolism inhibitor activity" EXACT [] synonym: "protein formation inhibitor activity" EXACT [] synonym: "protein synthesis inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0017148 [Term] id: GO:0017150 name: tRNA dihydrouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710] subset: gosubset_prok is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0017151 name: DEAD/H-box RNA helicase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0017153 name: sodium:dicarboxylate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "sodium:dicarboxylate cotransporter activity" BROAD [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0017154 name: semaphorin receptor activity namespace: molecular_function def: "Combining with a semaphorin to initiate a change in cell activity." [GOC:mah] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0017155 name: sodium:hydrogen antiporter regulator activity namespace: molecular_function alt_id: GO:0030040 def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it represents a biological process. synonym: "sodium:proton antiporter regulator" EXACT [] is_obsolete: true [Term] id: GO:0017156 name: calcium ion-dependent exocytosis namespace: biological_process def: "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, requiring the presence of calcium ions." [GOC:go_curators] is_a: GO:0006887 ! exocytosis [Term] id: GO:0017157 name: regulation of exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] subset: gosubset_prok is_a: GO:0051046 ! regulation of secretion is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0006887 ! exocytosis [Term] id: GO:0017158 name: regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] is_a: GO:0017157 ! regulation of exocytosis relationship: regulates GO:0017156 ! calcium ion-dependent exocytosis [Term] id: GO:0017159 name: pantetheine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448] synonym: "(R)-pantetheine amidohydrolase activity" EXACT [EC:3.5.1.92] synonym: "pantetheinase activity" EXACT [EC:3.5.1.92] synonym: "vanin" RELATED [EC:3.5.1.92] synonym: "vanin-1" RELATED [EC:3.5.1.92] xref: EC:3.5.1.92 xref: KEGG:R02973 xref: MetaCyc:3.5.1.92-RXN xref: RHEA:13448 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0017160 name: Ral GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Ral interactor activity" RELATED [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0017161 name: inositol-1,3,4-trisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3.- is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] id: GO:0017162 name: aryl hydrocarbon receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an aryl hydrocarbon receptor." [GOC:ai] is_a: GO:0005102 ! receptor binding is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0017163 name: basal transcription repressor activity namespace: molecular_function def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates basal transcription. Basal transcription results from transcription that is controlled by the minimal complement of proteins necessary to reconstitute transcription from a minimal promoter." [GOC:dph, GOC:tb, http://tfib.med.harvard.edu/transcription/basaltx.html] comment: To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok is_obsolete: true consider: GO:0001078 consider: GO:0001141 consider: GO:0045892 [Term] id: GO:0017164 name: nicotinic acetylcholine receptor-associated protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0017165 name: dipeptidase E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alpha-aspartyl dipeptidase activity" EXACT [] synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21] synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21] synonym: "peptidase E activity" BROAD [EC:3.4.13.21] xref: EC:3.4.13.21 xref: MetaCyc:3.4.13.21-RXN is_obsolete: true replaced_by: GO:0016805 [Term] id: GO:0017166 name: vinculin binding namespace: molecular_function def: "Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0017168 name: 5-oxoprolinase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate." [EC:3.5.2.9, RHEA:10351] subset: gosubset_prok synonym: "5-OPase activity" EXACT [EC:3.5.2.9] synonym: "5-oxo-L-prolinase activity" EXACT [EC:3.5.2.9] synonym: "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "5-oxoprolinase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "5-oxoprolinase activity" EXACT [EC:3.5.2.9] synonym: "L-pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] synonym: "oxoprolinase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "pyroglutamase (ATP-hydrolyzing) activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamic hydrolase activity" EXACT [EC:3.5.2.9] xref: EC:3.5.2.9 xref: KEGG:R00251 xref: MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN xref: RHEA:10351 xref: Wikipedia:5-oxoprolinase_(ATP-hydrolysing) is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0017169 name: CDP-alcohol phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai] subset: gosubset_prok is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0017170 name: KU70 binding namespace: molecular_function def: "Interacting selectively and non-covalently with Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985] is_a: GO:0005515 ! protein binding [Term] id: GO:0017171 name: serine hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0017172 name: cysteine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+)." [EC:1.13.11.20, RHEA:20444] subset: gosubset_prok xref: EC:1.13.11.20 xref: KEGG:R00893 xref: MetaCyc:CYSTEINE-DIOXYGENASE-RXN xref: RHEA:20444 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0017174 name: glycine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20] synonym: "glycine methyltransferase activity" EXACT [EC:2.1.1.20] synonym: "GNMT" RELATED [EC:2.1.1.20] synonym: "S-adenosyl-L-methionine:glycine methyltransferase activity" EXACT [EC:2.1.1.20] synonym: "S-adenosyl-L-methionine:glycine N-methyltransferase activity" EXACT [EC:2.1.1.20] xref: EC:2.1.1.20 xref: MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0017175 name: IMP-GMP specific 5'-nucleotidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile." [EC:3.1.3.5, GOC:krc] comment: This term was made obsolete because it represents a gene product with two different activities. is_obsolete: true consider: GO:0050484 [Term] id: GO:0017176 name: phosphatidylinositol N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198] synonym: "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity" EXACT [EC:2.4.1.198] synonym: "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] synonym: "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] synonym: "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] xref: EC:2.4.1.198 xref: MetaCyc:2.4.1.198-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0017177 name: alpha-glucosidase II complex namespace: cellular_component def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term. is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0017178 name: diphthine-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + 2 H(+) + phosphate." [EC:6.3.2.22, RHEA:19756] synonym: "diphthamide synthase activity" EXACT [EC:6.3.2.22] synonym: "diphthamide synthetase activity" EXACT [EC:6.3.2.22] synonym: "diphthine:ammonia ligase (ADP-forming)" EXACT [EC:6.3.2.22] xref: EC:6.3.2.22 xref: KEGG:R03613 xref: MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN xref: RHEA:19756 is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0017179 name: peptidyl-diphthine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] subset: gosubset_prok synonym: "peptidyl-diphthine metabolism" EXACT [] is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0017180 name: peptidyl-diphthine biosynthetic process from peptidyl-histidine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine." [GOC:go_curators] subset: gosubset_prok synonym: "peptidyl-diphthine anabolism from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthine formation from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthine synthesis from peptidyl-histidine" EXACT [] is_a: GO:0017179 ! peptidyl-diphthine metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0017181 name: peptidyl-diphthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] subset: gosubset_prok synonym: "peptidyl-diphthine breakdown" EXACT [] synonym: "peptidyl-diphthine catabolism" EXACT [] synonym: "peptidyl-diphthine degradation" EXACT [] is_a: GO:0017179 ! peptidyl-diphthine metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0017182 name: peptidyl-diphthamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] subset: gosubset_prok synonym: "peptidyl-diphthamide metabolism" EXACT [] is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0017183 name: peptidyl-diphthamide biosynthetic process from peptidyl-histidine namespace: biological_process def: "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2." [RESID:AA0040] subset: gosubset_prok synonym: "peptidyl-diphthamide anabolism from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthamide formation from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthamide synthesis from peptidyl-histidine" EXACT [] xref: RESID:AA0040 is_a: GO:0017182 ! peptidyl-diphthamide metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0017184 name: peptidyl-diphthamide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] subset: gosubset_prok synonym: "peptidyl-diphthamide breakdown" EXACT [] synonym: "peptidyl-diphthamide catabolism" EXACT [] synonym: "peptidyl-diphthamide degradation" EXACT [] is_a: GO:0017182 ! peptidyl-diphthamide metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0017185 name: peptidyl-lysine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai] subset: gosubset_prok is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0017186 name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031] comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'. subset: gosubset_prok synonym: "2-pyrrolidone-5-carboxylic acid biosynthesis" EXACT [] synonym: "2-pyrrolidone-5-carboxylic acid biosynthetic process" EXACT [] synonym: "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase" EXACT [] synonym: "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase" EXACT [] synonym: "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase" EXACT [] xref: RESID:AA0031 is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0017187 name: peptidyl-glutamic acid carboxylation namespace: biological_process def: "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032] comment: See also the molecular function term 'gamma-glutamyl carboxylase activity ; GO:0008488'. subset: gosubset_prok xref: Reactome:1253302 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: Reactome:1253306 "Gamma-carboxylation of protein precursors" xref: Reactome:1280242 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: Reactome:1280246 "Gamma-carboxylation of protein precursors" xref: Reactome:1299102 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: Reactome:1326818 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: Reactome:1326822 "Gamma-carboxylation of protein precursors" xref: Reactome:1352919 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: Reactome:1352923 "Gamma-carboxylation of protein precursors" xref: Reactome:1373125 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: Reactome:1393141 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: Reactome:1417624 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: Reactome:1417628 "Gamma-carboxylation of protein precursors" xref: Reactome:1450724 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: Reactome:1450728 "Gamma-carboxylation of protein precursors" xref: Reactome:159740 "Gamma-carboxylation of protein precursors" xref: Reactome:159854 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" xref: RESID:AA0032 is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018214 ! protein carboxylation [Term] id: GO:0017188 name: aspartate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+)." [EC:2.3.1.17, RHEA:14168] synonym: "acetyl-CoA:L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] synonym: "aspartate acetyltransferase activity" EXACT [EC:2.3.1.17] synonym: "L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] xref: EC:2.3.1.17 xref: KEGG:R00487 xref: MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN xref: RHEA:14168 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0017189 name: N-terminal peptidyl-alanine acetylation namespace: biological_process def: "The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase." [RESID:AA0041] comment: See also the molecular function terms 'peptide alpha-N-acetyltransferase activity ; GO:0004596' and 'ribosomal-protein-alanine N-acetyltransferase activity ; GO:0008999'. subset: gosubset_prok xref: RESID:AA0041 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0017190 name: N-terminal peptidyl-aspartic acid acetylation namespace: biological_process def: "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042] comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. subset: gosubset_prok xref: RESID:AA0042 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0017192 name: N-terminal peptidyl-glutamine acetylation namespace: biological_process def: "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable." [RESID:AA0045] subset: gosubset_prok xref: RESID:AA0045 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0017193 name: N-terminal peptidyl-glycine acetylation namespace: biological_process def: "The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine." [RESID:AA0046] subset: gosubset_prok xref: RESID:AA0046 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0017194 name: N-terminal peptidyl-isoleucine acetylation namespace: biological_process def: "The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed." [RESID:AA0047] subset: gosubset_prok xref: RESID:AA0047 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018203 ! peptidyl-isoleucine modification [Term] id: GO:0017195 name: N-terminal peptidyl-lysine N2-acetylation namespace: biological_process def: "The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed." [RESID:AA0048] subset: gosubset_prok xref: RESID:AA0048 is_a: GO:0018076 ! N-terminal peptidyl-lysine acetylation [Term] id: GO:0017196 name: N-terminal peptidyl-methionine acetylation namespace: biological_process def: "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049] subset: gosubset_prok xref: RESID:AA0049 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0017197 name: N-terminal peptidyl-proline acetylation namespace: biological_process def: "The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline." [RESID:AA0050] subset: gosubset_prok xref: RESID:AA0050 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0017198 name: N-terminal peptidyl-serine acetylation namespace: biological_process def: "The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine." [RESID:AA0051] subset: gosubset_prok xref: RESID:AA0051 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030920 ! peptidyl-serine acetylation [Term] id: GO:0017199 name: N-terminal peptidyl-threonine acetylation namespace: biological_process def: "The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0052] comment: See also the molecular function term 'peptide alpha-N-acetyltransferase activity ; GO:0004596'. subset: gosubset_prok xref: RESID:AA0052 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018000 name: N-terminal peptidyl-tyrosine acetylation namespace: biological_process def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine." [RESID:AA0053] subset: gosubset_prok xref: RESID:AA0053 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018001 name: N-terminal peptidyl-valine acetylation namespace: biological_process def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine." [RESID:AA0054] subset: gosubset_prok xref: RESID:AA0054 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018213 ! peptidyl-valine modification [Term] id: GO:0018002 name: N-terminal peptidyl-glutamic acid acetylation namespace: biological_process def: "The acetylation of the N-terminal glutamic acid of proteins; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0044] comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. subset: gosubset_prok xref: RESID:AA0044 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018003 name: peptidyl-lysine N6-acetylation namespace: biological_process def: "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine; catalyzed by tubulin N-acetyltransferase." [RESID:AA0055] comment: See also the molecular function term 'tubulin N-acetyltransferase activity ; GO:0019799'. subset: gosubset_prok xref: RESID:AA0055 is_a: GO:0018393 ! internal peptidyl-lysine acetylation [Term] id: GO:0018004 name: N-terminal protein formylation namespace: biological_process def: "The formylation of the N-terminal amino acid of proteins." [GOC:ai] subset: gosubset_prok is_a: GO:0018256 ! protein formylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018005 name: N-terminal peptidyl-glycine N-formylation namespace: biological_process def: "The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine." [RESID:AA0057] subset: gosubset_prok xref: RESID:AA0057 is_a: GO:0018004 ! N-terminal protein formylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018006 name: N-terminal protein amino acid glucuronylation namespace: biological_process def: "The glucuronylation of the N-terminal amino acid of proteins." [GOC:ai] subset: gosubset_prok is_a: GO:0018321 ! protein glucuronylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018007 name: N-terminal peptidyl-glycine N-glucuronylation namespace: biological_process def: "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine." [RESID:AA0058] subset: gosubset_prok xref: RESID:AA0058 is_a: GO:0018006 ! N-terminal protein amino acid glucuronylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018008 name: N-terminal peptidyl-glycine N-myristoylation namespace: biological_process def: "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059] subset: gosubset_prok synonym: "N-terminal peptidyl-glycine N-myristylation" EXACT [] xref: RESID:AA0059 is_a: GO:0006499 ! N-terminal protein myristoylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018009 name: N-terminal peptidyl-L-cysteine N-palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine." [RESID:AA0060] subset: gosubset_prok xref: RESID:AA0060 is_a: GO:0006500 ! N-terminal protein palmitoylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018010 name: glycoprotein N-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96] synonym: "mucus glycoprotein fatty acyltransferase" NARROW [EC:2.3.1.96] synonym: "palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity" EXACT [EC:2.3.1.96] xref: EC:2.3.1.96 xref: MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN is_a: GO:0019105 ! N-palmitoyltransferase activity [Term] id: GO:0018011 name: N-terminal peptidyl-alanine methylation namespace: biological_process def: "The methylation of the N-terminal alanine of proteins." [RESID:AA0061, RESID:AA0062] subset: gosubset_prok xref: RESID:AA0061 xref: RESID:AA0062 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0018012 name: N-terminal peptidyl-alanine trimethylation namespace: biological_process def: "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine." [RESID:AA0062] subset: gosubset_prok xref: RESID:AA0062 is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation [Term] id: GO:0018013 name: N-terminal peptidyl-glycine methylation namespace: biological_process def: "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine." [RESID:AA0063] subset: gosubset_prok xref: RESID:AA0063 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018014 name: N-terminal peptidyl-methionine methylation namespace: biological_process def: "The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine." [RESID:AA0064] subset: gosubset_prok xref: RESID:AA0064 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018015 name: N-terminal peptidyl-phenylalanine methylation namespace: biological_process def: "The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine." [RESID:AA0065] subset: gosubset_prok xref: RESID:AA0065 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018016 name: N-terminal peptidyl-proline dimethylation namespace: biological_process def: "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066] subset: gosubset_prok xref: RESID:AA0066 is_a: GO:0035568 ! N-terminal peptidyl-proline methylation [Term] id: GO:0018019 name: N-terminal peptidyl-glutamine methylation namespace: biological_process def: "The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative." [RESID:AA0071] subset: gosubset_prok xref: RESID:AA0071 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0018020 name: peptidyl-glutamic acid methylation namespace: biological_process def: "The addition of a methyl group to a glutamic acid residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006479 ! protein methylation [Term] id: GO:0018021 name: peptidyl-histidine methylation namespace: biological_process def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317] subset: gosubset_prok xref: RESID:AA0073 xref: RESID:AA0317 is_a: GO:0006479 ! protein methylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018022 name: peptidyl-lysine methylation namespace: biological_process def: "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai] subset: gosubset_prok is_a: GO:0006479 ! protein methylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018023 name: peptidyl-lysine trimethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074] subset: gosubset_prok xref: RESID:AA0074 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0018024 name: histone-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "histone-lysine N-methylase activity" EXACT [GOC:mah] synonym: "protein (lysine) methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "protein methylase 3 activity" NARROW [EC:2.1.1.43] synonym: "protein methylase III activity" NARROW [EC:2.1.1.43] synonym: "protein methyltransferase II activity" NARROW [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.43] xref: EC:2.1.1.43 xref: MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN xref: RESID:AA0074 xref: RESID:AA0075 xref: RESID:AA0076 is_a: GO:0016279 ! protein-lysine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity [Term] id: GO:0018025 name: calmodulin-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60] synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.60] synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.60] synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" EXACT [EC:2.1.1.60] xref: EC:2.1.1.60 xref: MetaCyc:2.1.1.60-RXN is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0018026 name: peptidyl-lysine monomethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076] subset: gosubset_prok xref: RESID:AA0076 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0018027 name: peptidyl-lysine dimethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine." [RESID:AA0075] subset: gosubset_prok xref: RESID:AA0075 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0018028 name: peptidyl-lysine myristoylation namespace: biological_process def: "The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine." [RESID:AA0078] subset: gosubset_prok synonym: "peptidyl-lysine myristylation" EXACT [] xref: RESID:AA0078 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018377 ! protein myristoylation [Term] id: GO:0018029 name: peptidyl-lysine palmitoylation namespace: biological_process def: "The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine." [RESID:AA0077] subset: gosubset_prok xref: RESID:AA0077 is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018030 name: peptidyl-lysine N6-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah] xref: EC:2.3.1.- is_a: GO:0019107 ! myristoyltransferase activity [Term] id: GO:0018031 name: peptidyl-lysine N6-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah] xref: EC:2.3.1.- is_a: GO:0019105 ! N-palmitoyltransferase activity [Term] id: GO:0018032 name: protein amidation namespace: biological_process def: "Addition of an amide group from a glycine to a protein amino acid." [SP_KW:KW-0027] subset: gosubset_prok synonym: "protein amino acid amidation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018033 name: protein C-terminal amidation namespace: biological_process def: "The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein." [GOC:ai] subset: gosubset_prok is_a: GO:0018032 ! protein amidation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0018034 name: C-terminal peptidyl-alanine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein." [RESID:AA0081] subset: gosubset_prok xref: RESID:AA0081 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0018035 name: C-terminal peptidyl-arginine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein." [RESID:AA0082] subset: gosubset_prok xref: RESID:AA0082 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018036 name: C-terminal peptidyl-asparagine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein." [RESID:AA0083] subset: gosubset_prok xref: RESID:AA0083 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018037 name: C-terminal peptidyl-aspartic acid amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein." [RESID:AA0084] subset: gosubset_prok xref: RESID:AA0084 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0018038 name: C-terminal peptidyl-cysteine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein." [RESID:AA0085] subset: gosubset_prok xref: RESID:AA0085 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018039 name: C-terminal peptidyl-glutamine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein." [RESID:AA0086] subset: gosubset_prok xref: RESID:AA0086 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0018040 name: C-terminal peptidyl-glutamic acid amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein." [RESID:AA0087] subset: gosubset_prok xref: RESID:AA0087 is_a: GO:0018033 ! protein C-terminal amidation [Term] id: GO:0018041 name: C-terminal peptidyl-glycine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein." [RESID:AA0088] subset: gosubset_prok xref: RESID:AA0088 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018042 name: C-terminal peptidyl-histidine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein." [RESID:AA0089] subset: gosubset_prok xref: RESID:AA0089 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018043 name: C-terminal peptidyl-isoleucine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein." [RESID:AA0090] subset: gosubset_prok xref: RESID:AA0090 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018203 ! peptidyl-isoleucine modification [Term] id: GO:0018044 name: C-terminal peptidyl-leucine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein." [RESID:AA0091] subset: gosubset_prok xref: RESID:AA0091 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018204 ! peptidyl-leucine modification [Term] id: GO:0018045 name: C-terminal peptidyl-lysine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein." [RESID:AA0092] subset: gosubset_prok xref: RESID:AA0092 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018046 name: C-terminal peptidyl-methionine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein." [RESID:AA0093] subset: gosubset_prok xref: RESID:AA0093 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018047 name: C-terminal peptidyl-phenylalanine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein." [RESID:AA0094] subset: gosubset_prok xref: RESID:AA0094 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018048 name: C-terminal peptidyl-proline amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein." [RESID:AA0095] subset: gosubset_prok xref: RESID:AA0095 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0018049 name: C-terminal peptidyl-serine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein." [RESID:AA0096] subset: gosubset_prok xref: RESID:AA0096 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018050 name: C-terminal peptidyl-threonine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein." [RESID:AA0097] subset: gosubset_prok xref: RESID:AA0097 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018051 name: C-terminal peptidyl-tryptophan amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein." [RESID:AA0098] subset: gosubset_prok xref: RESID:AA0098 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018052 name: C-terminal peptidyl-tyrosine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein." [RESID:AA0099] subset: gosubset_prok xref: RESID:AA0099 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018053 name: C-terminal peptidyl-valine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein." [RESID:AA0100] subset: gosubset_prok xref: RESID:AA0100 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018213 ! peptidyl-valine modification [Term] id: GO:0018054 name: peptidyl-lysine biotinylation namespace: biological_process def: "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117] subset: gosubset_prok xref: RESID:AA0117 is_a: GO:0009305 ! protein biotinylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018055 name: peptidyl-lysine lipoylation namespace: biological_process def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118] subset: gosubset_prok xref: RESID:AA0118 is_a: GO:0009249 ! protein lipoylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018057 name: peptidyl-lysine oxidation namespace: biological_process def: "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121] subset: gosubset_prok xref: RESID:AA0121 is_a: GO:0018158 ! protein oxidation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018058 name: N-terminal protein amino acid deamination, from amino carbon namespace: biological_process def: "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol." [RESID:AA0127, RESID:AA0128, RESID:AA0129] subset: gosubset_prok xref: RESID:AA0127 xref: RESID:AA0128 xref: RESID:AA0129 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018277 ! protein deamination is_a: GO:0031363 ! N-terminal protein amino acid deamination [Term] id: GO:0018059 name: N-terminal peptidyl-serine deamination namespace: biological_process def: "The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] subset: gosubset_prok is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018060 name: N-terminal peptidyl-cysteine deamination namespace: biological_process def: "The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] subset: gosubset_prok is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018061 name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine namespace: biological_process def: "The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128] subset: gosubset_prok synonym: "peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine" EXACT [] synonym: "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine" EXACT [] synonym: "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine" EXACT [] xref: RESID:AA0128 is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018062 name: peptidyl-tryptophan succinylation namespace: biological_process def: "The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan." [RESID:AA0130] subset: gosubset_prok xref: RESID:AA0130 is_a: GO:0018211 ! peptidyl-tryptophan modification is_a: GO:0018335 ! protein succinylation [Term] id: GO:0018063 name: cytochrome c-heme linkage namespace: biological_process def: "The linkage of cytochromes and other heme proteins to heme." [RESID:AA0134, RESID:AA0135] subset: gosubset_prok synonym: "cytochrome c-haem linkage" EXACT [] xref: RESID:AA0134 xref: RESID:AA0135 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0018064 name: protein-histidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine." [EC:2.1.1.85] synonym: "actin-specific histidine methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "peptidyl-histidine N-methyltransferase activity" EXACT [] synonym: "protein (histidine) methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "protein methylase IV activity" NARROW [EC:2.1.1.85] synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" EXACT [EC:2.1.1.85] xref: EC:2.1.1.85 xref: MetaCyc:2.1.1.85-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018065 name: protein-cofactor linkage namespace: biological_process def: "The covalent attachment of a cofactor to a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0006464 ! protein modification process [Term] id: GO:0018067 name: peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA)." [RESID:AA0146] subset: gosubset_prok synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] xref: RESID:AA0146 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation [Term] id: GO:0018068 name: peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases." [RESID:AA0147] subset: gosubset_prok synonym: "peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine" EXACT [] xref: RESID:AA0147 is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018069 name: peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone namespace: biological_process def: "The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase." [RESID:AA0149] subset: gosubset_prok xref: RESID:AA0149 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018070 name: peptidyl-serine phosphopantetheinylation namespace: biological_process def: "The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine." [RESID:AA0150] subset: gosubset_prok xref: RESID:AA0150 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018215 ! protein phosphopantetheinylation [Term] id: GO:0018071 name: NAD(P)-cysteine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [EC:2.4.2.-] xref: EC:2.4.2.- is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0018072 name: peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid namespace: biological_process def: "The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit." [PMID:2569467, RESID:AA0170] subset: gosubset_prok synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid" EXACT [] synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid" EXACT [] synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid" EXACT [] xref: RESID:AA0170 is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018073 name: protein bromination namespace: biological_process def: "The addition of one or more bromine atoms to an amino acid residue in a protein." [GOC:mah] subset: gosubset_prok synonym: "protein amino acid bromination" EXACT [GOC:bf] is_a: GO:0018079 ! protein halogenation [Term] id: GO:0018074 name: peptidyl-histidine bromination namespace: biological_process def: "The bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown." [RESID:AA0173] subset: gosubset_prok xref: RESID:AA0173 is_a: GO:0018073 ! protein bromination is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018075 name: peptidyl-phenylalanine bromination namespace: biological_process def: "The bromination of phenylalanine." [RESID:AA0174, RESID:AA0175, RESID:AA0176] subset: gosubset_prok xref: RESID:AA0174 xref: RESID:AA0175 xref: RESID:AA0176 is_a: GO:0018073 ! protein bromination is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018076 name: N-terminal peptidyl-lysine acetylation namespace: biological_process def: "The acetylation of the N-terminal lysine of proteins." [GOC:ai] subset: gosubset_prok is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018394 ! peptidyl-lysine acetylation [Term] id: GO:0018077 name: protein iodination namespace: biological_process def: "The addition of one or more iodine atoms to an amino acid residue in a protein." [GOC:mah] subset: gosubset_prok synonym: "protein amino acid iodination" EXACT [GOC:bf] is_a: GO:0018079 ! protein halogenation [Term] id: GO:0018078 name: peptidyl-thyronine iodination namespace: biological_process def: "The iodination of peptidyl-thyronine, formed from tyrosine." [RESID:AA0177, RESID:AA0178] subset: gosubset_prok xref: RESID:AA0177 xref: RESID:AA0178 is_a: GO:0018077 ! protein iodination is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018079 name: protein halogenation namespace: biological_process def: "The addition of a halogen to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid halogenation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process is_a: GO:0070276 ! halogen metabolic process [Term] id: GO:0018080 name: peptidyl-tryptophan bromination namespace: biological_process def: "The bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan." [RESID:AA0179] subset: gosubset_prok xref: RESID:AA0179 is_a: GO:0018073 ! protein bromination is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018081 name: peptide cross-linking via lanthionine or 3-methyl-lanthionine namespace: biological_process def: "The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process." [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112] subset: gosubset_prok synonym: "peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine" EXACT [] synonym: "peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine" EXACT [] xref: RESID:AA0110 xref: RESID:AA0111 xref: RESID:AA0112 is_a: GO:0018149 ! peptide cross-linking [Term] id: GO:0018082 name: peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine namespace: biological_process def: "The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine." [RESID:AA0182] subset: gosubset_prok synonym: "peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine" EXACT [] synonym: "peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine" EXACT [] synonym: "peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine" EXACT [] xref: RESID:AA0182 is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018083 name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine namespace: biological_process def: "The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185] subset: gosubset_prok synonym: "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine" EXACT [] synonym: "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine" EXACT [] synonym: "peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine" EXACT [] xref: RESID:AA0185 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018084 name: peptidyl-lactic acid biosynthetic process from peptidyl-serine namespace: biological_process def: "The modification of N-terminal peptidyl-serine to lactic acid." [RESID:AA0186] subset: gosubset_prok synonym: "peptidyl-lactic acid anabolism from peptidyl-serine" EXACT [] synonym: "peptidyl-lactic acid formation from peptidyl-serine" EXACT [] synonym: "peptidyl-lactic acid synthesis from peptidyl-serine" EXACT [] xref: RESID:AA0186 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018085 name: peptidyl-L-amino acid racemization namespace: biological_process def: "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification is_a: GO:0018366 ! chiral amino acid racemization [Term] id: GO:0018086 name: alanine racemization namespace: biological_process alt_id: GO:0018368 def: "OBSOLETE (was not defined before being made obsolete)." [RESID:AA0191] comment: This term was made obsolete because it was replaced with more appropriate terms. is_obsolete: true consider: GO:0019122 [Term] id: GO:0018091 name: peptidyl-asparagine racemization namespace: biological_process alt_id: GO:0018373 alt_id: GO:0019127 def: "The racemization of peptidyl-asparagine." [RESID:AA0196] subset: gosubset_prok xref: RESID:AA0196 is_a: GO:0018085 ! peptidyl-L-amino acid racemization is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018094 name: protein polyglycylation namespace: biological_process def: "The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201] subset: gosubset_prok xref: RESID:AA0201 is_a: GO:0006464 ! protein modification process [Term] id: GO:0018095 name: protein polyglutamylation namespace: biological_process def: "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202] subset: gosubset_prok xref: RESID:AA0202 is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018096 name: peptide cross-linking via S-(2-aminovinyl)-D-cysteine namespace: biological_process def: "The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine." [RESID:AA0204] subset: gosubset_prok xref: RESID:AA0204 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018097 name: protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine namespace: biological_process def: "The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine." [RESID:AA0207] subset: gosubset_prok synonym: "protein amino acid cinnamylation" BROAD [] xref: RESID:AA0207 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0018101 name: peptidyl-citrulline biosynthetic process from peptidyl-arginine namespace: biological_process def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline." [RESID:AA0214] subset: gosubset_prok synonym: "peptidyl-citrulline anabolism from peptidyl-arginine" EXACT [] synonym: "peptidyl-citrulline formation from peptidyl-arginine" EXACT [] synonym: "peptidyl-citrulline synthesis from peptidyl-arginine" EXACT [] xref: RESID:AA0214 is_a: GO:0018195 ! peptidyl-arginine modification is_a: GO:0019240 ! citrulline biosynthetic process [Term] id: GO:0018102 name: peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine namespace: biological_process def: "The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine." [RESID:AA0215] subset: gosubset_prok xref: RESID:AA0215 is_a: GO:0018126 ! protein hydroxylation is_a: GO:0030961 ! peptidyl-arginine hydroxylation [Term] id: GO:0018103 name: protein C-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a sugar unit is added to a protein via a C atom." [PMID:7947762, RESID:AA0217] subset: gosubset_prok synonym: "protein amino acid C-linked glycosylation" EXACT [GOC:bf] xref: RESID:AA0217 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0018104 name: peptidoglycan-protein cross-linking namespace: biological_process def: "The process of covalently linking peptidoglycan (murein) to proteins." [GOC:jsg] subset: gosubset_prok is_a: GO:0009252 ! peptidoglycan biosynthetic process [Term] id: GO:0018105 name: peptidyl-serine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] subset: gosubset_prok xref: RESID:AA0037 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018106 name: peptidyl-histidine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036] subset: gosubset_prok xref: RESID:AA0035 xref: RESID:AA0036 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018107 name: peptidyl-threonine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038] subset: gosubset_prok xref: RESID:AA0038 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018108 name: peptidyl-tyrosine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] subset: gosubset_prok xref: RESID:AA0039 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018109 name: peptidyl-arginine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine." [RESID:AA0222] subset: gosubset_prok xref: RESID:AA0222 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018110 name: histone arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+)." [GOC:mah] synonym: "histone-arginine kinase activity" EXACT [] xref: EC:2.7.3.- is_a: GO:0004054 ! arginine kinase activity is_a: GO:0035173 ! histone kinase activity [Term] id: GO:0018111 name: methionine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine = D-methionine." [EC:5.1.1.2, RHEA:12495] xref: EC:5.1.1.2 xref: KEGG:R00655 xref: MetaCyc:METHIONINE-RACEMASE-RXN xref: RHEA:12495 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018112 name: proline racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline = D-proline." [EC:5.1.1.4, RHEA:10683] subset: gosubset_prok xref: EC:5.1.1.4 xref: KEGG:R01255 xref: MetaCyc:PROLINE-RACEMASE-RXN xref: RHEA:10683 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018113 name: lysine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine = D-lysine." [EC:5.1.1.5] xref: EC:5.1.1.5 xref: MetaCyc:LYSINE-RACEMASE-RXN is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018114 name: threonine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = D-threonine." [EC:5.1.1.6, RHEA:13916] xref: EC:5.1.1.6 xref: KEGG:R01467 xref: MetaCyc:THREONINE-RACEMASE-RXN xref: RHEA:13916 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018115 name: peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine." [PMID:7797461, RESID:AA0223] subset: gosubset_prok synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0223 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018116 name: peptidyl-lysine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine." [RESID:AA0227] subset: gosubset_prok synonym: "peptidyl-lysine adenylation" EXACT [] xref: RESID:AA0227 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018117 name: protein adenylylation namespace: biological_process alt_id: GO:0018176 def: "The addition of phospho-adenosine to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein adenylation" EXACT [] synonym: "protein amino acid adenylylation" EXACT [GOC:bf] is_a: GO:0018175 ! protein nucleotidylation [Term] id: GO:0018118 name: peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide." [RESID:AA0229] subset: gosubset_prok synonym: "peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine" EXACT [] xref: RESID:AA0229 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018119 name: peptidyl-cysteine S-nitrosylation namespace: biological_process def: "The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine." [RESID:AA0230] subset: gosubset_prok synonym: "protein S-nitrosylation" EXACT [PMID:20972426] synonym: "S-nitrosylation" EXACT [PMID:20972426] xref: RESID:AA0230 is_a: GO:0017014 ! protein nitrosylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018120 name: peptidyl-arginine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168] subset: gosubset_prok xref: RESID:AA0168 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018121 name: NAD(P)-asparagine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [EC:2.4.2.-] xref: EC:2.4.2.- is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0018122 name: peptidyl-asparagine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine." [RESID:AA0231] subset: gosubset_prok xref: RESID:AA0231 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018123 name: peptidyl-cysteine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine." [RESID:AA0169] subset: gosubset_prok xref: RESID:AA0169 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018124 name: peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone namespace: biological_process def: "The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue." [RESID:AA0233] subset: gosubset_prok xref: RESID:AA0233 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018125 name: peptidyl-cysteine methylation namespace: biological_process def: "The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine." [RESID:AA0234] subset: gosubset_prok xref: RESID:AA0234 is_a: GO:0006479 ! protein methylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018126 name: protein hydroxylation namespace: biological_process def: "The addition of a hydroxy group to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid hydroxylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018127 name: NAD(P)-serine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [EC:2.4.2.-] xref: EC:2.4.2.- is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0018128 name: peptidyl-serine cyclase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. xref: EC:4.2.1.- is_obsolete: true [Term] id: GO:0018129 name: peptidyl-oxazoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reduction of a peptide-linked oxazoline to oxazole." [GOC:mah, PMID:19058272] xref: EC:1.3.-.- is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018130 name: heterocycle biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684] subset: gosubset_prok synonym: "heterocycle anabolism" EXACT [] synonym: "heterocycle biosynthesis" EXACT [] synonym: "heterocycle formation" EXACT [] synonym: "heterocycle synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018131 name: oxazole or thiazole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [CHEBI:35790, CHEBI:48901, GOC:curators] subset: gosubset_prok synonym: "oxazole or thiazole anabolism" EXACT [] synonym: "oxazole or thiazole biosynthesis" EXACT [] synonym: "oxazole or thiazole formation" EXACT [] synonym: "oxazole or thiazole synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046484 ! oxazole or thiazole metabolic process [Term] id: GO:0018132 name: peptide cross-linking via L-cysteine oxazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [PMID:8895467, RESID:AA0238] subset: gosubset_prok xref: RESID:AA0238 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018133 name: peptide cross-linking via L-cysteine oxazolinecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue." [RESID:AA0239] subset: gosubset_prok xref: RESID:AA0239 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018134 name: peptide cross-linking via glycine oxazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0240] subset: gosubset_prok xref: RESID:AA0240 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018135 name: peptidyl-cysteine cyclase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. xref: EC:4.2.1.- is_obsolete: true [Term] id: GO:0018136 name: peptidyl-thiazoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reduction of a peptide-linked thiazoline to thiazole." [GOC:mah, PMID:19058272] xref: EC:1.3.-.- is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018137 name: peptide cross-linking via glycine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0241] subset: gosubset_prok xref: RESID:AA0241 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018138 name: peptide cross-linking via L-serine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0242] subset: gosubset_prok xref: RESID:AA0242 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018139 name: peptide cross-linking via L-phenylalanine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0243] subset: gosubset_prok xref: RESID:AA0243 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018140 name: peptide cross-linking via L-cysteine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0244] subset: gosubset_prok xref: RESID:AA0244 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018141 name: peptide cross-linking via L-lysine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0245] subset: gosubset_prok xref: RESID:AA0245 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018142 name: protein-DNA covalent cross-linking namespace: biological_process def: "The formation of a covalent cross-link between DNA and a protein." [GOC:ma] subset: gosubset_prok synonym: "DNA-protein covalent cross-linking" EXACT [GOC:mah] is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking [Term] id: GO:0018143 name: nucleic acid-protein covalent cross-linking namespace: biological_process def: "The formation of a covalent cross-link between a nucleic acid and a protein." [GOC:ma] subset: gosubset_prok is_a: GO:0006464 ! protein modification process [Term] id: GO:0018144 name: RNA-protein covalent cross-linking namespace: biological_process def: "The formation of a covalent cross-link between RNA and a protein." [GOC:ma] subset: gosubset_prok is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking [Term] id: GO:0018145 name: protein-DNA covalent cross-linking via peptidyl-serine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine." [RESID:AA0246] subset: gosubset_prok synonym: "DNA-protein covalent cross-linking via peptidyl-serine" EXACT [GOC:mah] xref: RESID:AA0246 is_a: GO:0018142 ! protein-DNA covalent cross-linking is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018146 name: keratan sulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [ISBN:0198547684, RESID:AA0247] subset: gosubset_prok synonym: "keratan sulfate anabolism" EXACT [] synonym: "keratan sulfate biosynthesis" EXACT [] synonym: "keratan sulfate formation" EXACT [] synonym: "keratan sulfate synthesis" EXACT [] synonym: "keratan sulphate biosynthesis" EXACT [] synonym: "keratan sulphate biosynthetic process" EXACT [] xref: RESID:AA0247 is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0042339 ! keratan sulfate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0018147 name: molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) namespace: biological_process def: "The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0248] subset: gosubset_prok xref: RESID:AA0248 is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex is_a: GO:0050844 ! peptidyl-selenocysteine modification [Term] id: GO:0018148 name: RNA-protein covalent cross-linking via peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine." [RESID:AA0249] subset: gosubset_prok xref: RESID:AA0249 is_a: GO:0018144 ! RNA-protein covalent cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018149 name: peptide cross-linking namespace: biological_process def: "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] subset: gosubset_prok is_a: GO:0006464 ! protein modification process [Term] id: GO:0018150 name: peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0250] subset: gosubset_prok xref: RESID:AA0250 is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine [Term] id: GO:0018151 name: peptide cross-linking via L-histidyl-L-tyrosine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link." [GOC:ai] subset: gosubset_prok is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018152 name: peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0270] subset: gosubset_prok xref: RESID:AA0270 is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine [Term] id: GO:0018153 name: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine." [RESID:AA0124] subset: gosubset_prok xref: RESID:AA0124 is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0018154 name: peptide cross-linking via (2R,6R)-lanthionine namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine)." [RESID:AA0110] subset: gosubset_prok xref: RESID:AA0110 is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018155 name: peptide cross-linking via sn-(2S,6R)-lanthionine namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione)." [RESID:AA0111] subset: gosubset_prok xref: RESID:AA0111 is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018156 name: peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine)." [RESID:AA0112] subset: gosubset_prok xref: RESID:AA0112 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018157 name: peptide cross-linking via an oxazole or thiazole namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [GOC:jsg] subset: gosubset_prok synonym: "peptide heterocycle biosynthesis" RELATED [GOC:mah] synonym: "peptide heterocycle biosynthetic process" RELATED [GOC:mah] synonym: "peptide heterocycle formation" RELATED [GOC:mah] synonym: "peptide heterocycle synthesis" RELATED [GOC:mah] is_a: GO:0018131 ! oxazole or thiazole biosynthetic process is_a: GO:0018149 ! peptide cross-linking [Term] id: GO:0018158 name: protein oxidation namespace: biological_process def: "The modification of a protein amino acid by oxidation." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid oxidation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0018159 name: peptidyl-methionine oxidation namespace: biological_process def: "The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone." [RESID:AA0251] subset: gosubset_prok xref: RESID:AA0251 is_a: GO:0018158 ! protein oxidation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018160 name: peptidyl-pyrromethane cofactor linkage namespace: biological_process alt_id: GO:0018354 alt_id: GO:0033035 def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [CHEBI:30410, RESID:AA0252] subset: gosubset_prok synonym: "dipyrromethane cofactor binding" RELATED [GOC:jsg] synonym: "peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine" EXACT [GOC:jsg] xref: RESID:AA0252 is_a: GO:0018065 ! protein-cofactor linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018161 name: dipyrrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03] subset: gosubset_prok synonym: "dipyrrin anabolism" EXACT [] synonym: "dipyrrin biosynthesis" EXACT [] synonym: "dipyrrin formation" EXACT [] synonym: "dipyrrin synthesis" EXACT [] synonym: "dipyrromethane biosynthesis" EXACT [] synonym: "dipyrromethane biosynthetic process" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046453 ! dipyrrin metabolic process [Term] id: GO:0018162 name: peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine namespace: biological_process def: "The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine." [RESID:AA0253] subset: gosubset_prok xref: RESID:AA0253 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018163 name: protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine." [RESID:AA0254] subset: gosubset_prok synonym: "DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine" EXACT [GOC:mah] xref: RESID:AA0254 is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine [Term] id: GO:0018164 name: protein-DNA covalent cross-linking via peptidyl-threonine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine." [RESID:AA0255] subset: gosubset_prok synonym: "DNA-protein covalent cross-linking via peptidyl-threonine" EXACT [GOC:mah] xref: RESID:AA0255 is_a: GO:0018142 ! protein-DNA covalent cross-linking is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018165 name: peptidyl-tyrosine uridylylation namespace: biological_process def: "The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase." [RESID:AA0256] subset: gosubset_prok xref: RESID:AA0256 is_a: GO:0018177 ! protein uridylylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018166 name: C-terminal protein-tyrosinylation namespace: biological_process def: "The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase." [RESID:AA0257] comment: See also the molecular function term 'tubulin-tyrosine ligase activity ; GO:0004835'. subset: gosubset_prok xref: RESID:AA0257 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018322 ! protein tyrosinylation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0018167 name: protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine namespace: biological_process def: "The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine." [RESID:AA0259] subset: gosubset_prok xref: RESID:AA0259 is_a: GO:0017011 ! protein-phycoerythrobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018168 name: protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine namespace: biological_process def: "The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine." [RESID:AA0132] subset: gosubset_prok xref: RESID:AA0132 is_a: GO:0017011 ! protein-phycoerythrobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018169 name: ribosomal S6-glutamic acid ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6." [GOC:mah, PMID:2570347] xref: EC:6.3.2.- is_a: GO:0070739 ! protein-glutamic acid ligase activity [Term] id: GO:0018170 name: C-terminal peptidyl-polyglutamic acid amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus." [RESID:AA0261] subset: gosubset_prok xref: RESID:AA0261 is_a: GO:0018040 ! C-terminal peptidyl-glutamic acid amidation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018171 name: peptidyl-cysteine oxidation namespace: biological_process def: "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262] subset: gosubset_prok xref: RESID:AA0205 xref: RESID:AA0262 is_a: GO:0018158 ! protein oxidation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018172 name: peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine." [RESID:AA0263] subset: gosubset_prok synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] xref: RESID:AA0263 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation [Term] id: GO:0018173 name: peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] subset: gosubset_prok synonym: "peptidyl-1-thioglycine anabolism from peptidyl-glycine" EXACT [] synonym: "peptidyl-1-thioglycine formation from peptidyl-glycine" EXACT [] synonym: "peptidyl-1-thioglycine synthesis from peptidyl-glycine" EXACT [] xref: RESID:AA0265 is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0044249 ! cellular biosynthetic process relationship: part_of GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process [Term] id: GO:0018174 name: protein-heme P460 linkage namespace: biological_process def: "The linkage of protein to heme P460." [RESID:AA0266, RESID:AA0271] subset: gosubset_prok synonym: "protein-haem P460 linkage" EXACT [] xref: RESID:AA0266 xref: RESID:AA0271 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0018175 name: protein nucleotidylation namespace: biological_process def: "The addition of a nucleotide to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid nucleotidylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018177 name: protein uridylylation namespace: biological_process def: "The addition of phospho-uridine to a protein amino acid." [GOC:jsg] subset: gosubset_prok synonym: "protein amino acid uridylylation" EXACT [GOC:bf] is_a: GO:0018175 ! protein nucleotidylation [Term] id: GO:0018178 name: peptidyl-threonine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine." [RESID:AA0267] subset: gosubset_prok synonym: "peptidyl-threonine adenylation" EXACT [] xref: RESID:AA0267 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018179 name: peptidyl-cysteine desulfurization namespace: biological_process def: "The desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate." [RESID:AA0269] subset: gosubset_prok synonym: "peptidyl-cysteine desulphurization" EXACT [] xref: RESID:AA0269 is_a: GO:0018180 ! protein desulfurization [Term] id: GO:0018180 name: protein desulfurization namespace: biological_process def: "The removal of a sulfur group from a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid desulfurisation" EXACT [] synonym: "protein amino acid desulfurization" EXACT [GOC:bf] synonym: "protein amino acid desulphurisation" EXACT [] synonym: "protein amino acid desulphurization" EXACT [] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018181 name: peptidyl-arginine C5-methylation namespace: biological_process def: "The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine." [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272] subset: gosubset_prok synonym: "peptidyl-arginine 5-methylation" EXACT [] xref: RESID:AA0272 is_a: GO:0035245 ! peptidyl-arginine C-methylation [Term] id: GO:0018182 name: protein-heme linkage via 3'-L-histidine namespace: biological_process def: "The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine)." [RESID:AA0276] subset: gosubset_prok synonym: "protein-haem linkage via 3'-L-histidine" EXACT [] xref: RESID:AA0276 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018183 name: enzyme active site formation via S-selenyl-L-cysteine namespace: biological_process def: "OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine." [RESID:AA0277] comment: This term was made obsolete because this structure does not exist. is_obsolete: true [Term] id: GO:0018184 name: protein polyamination namespace: biological_process def: "The modification of a protein amino acid by polyamination." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid polyamination" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018185 name: poly-N-methyl-propylamination namespace: biological_process def: "The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin." [RESID:AA0278] subset: gosubset_prok xref: RESID:AA0278 is_a: GO:0018184 ! protein polyamination is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018186 name: peroxidase-heme linkage namespace: biological_process def: "The covalent linkage of heme to peroxidase." [RESID:AA0279, RESID:AA0280] subset: gosubset_prok synonym: "peroxidase-haem linkage" EXACT [] xref: RESID:AA0279 xref: RESID:AA0280 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0018187 name: molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide namespace: biological_process def: "The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide." [RESID:AA0281] subset: gosubset_prok xref: RESID:AA0281 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0018188 name: peptidyl-proline di-hydroxylation namespace: biological_process def: "The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline." [RESID:AA0282] subset: gosubset_prok xref: RESID:AA0282 is_a: GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0018189 name: pyrroloquinoline quinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed." [PMID:7665488, RESID:AA0283] subset: gosubset_prok synonym: "coenzyme pyrroloquinoline-quinone biosynthesis" EXACT [] synonym: "coenzyme pyrroloquinoline-quinone biosynthetic process" EXACT [] synonym: "PQQ biosynthesis" EXACT [] synonym: "PQQ biosynthetic process" EXACT [] synonym: "pyrroloquinoline quinone anabolism" EXACT [] synonym: "pyrroloquinoline quinone biosynthesis" EXACT [] synonym: "pyrroloquinoline quinone formation" EXACT [] synonym: "pyrroloquinoline quinone synthesis" EXACT [] synonym: "pyrroloquinoline-quinone biosynthesis" EXACT [] synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT [] xref: RESID:AA0283 is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0045426 ! quinone cofactor biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0018190 name: protein octanoylation namespace: biological_process def: "The modification of a protein amino acid by formation of an ester or amide with octanoic acid." [GOC:jsg] subset: gosubset_prok synonym: "protein amino acid octanoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0018191 name: peptidyl-serine octanoylation namespace: biological_process def: "The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin." [PMID:10604470, RESID:AA0290] subset: gosubset_prok xref: RESID:AA0290 is_a: GO:0018190 ! protein octanoylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018192 name: enzyme active site formation via L-cysteine persulfide namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide. A persulfurated cysteine promotes active site reactivity in Azotobacter vinelandii Rhodanese." [PMID:11592406, RESID:AA0269] subset: gosubset_prok synonym: "enzyme active site formation via L-cysteine persulphide" EXACT [] xref: RESID:AA0269 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018193 name: peptidyl-amino acid modification namespace: biological_process def: "The alteration of an amino acid residue in a peptide." [GOC:mah] subset: gosubset_prok is_a: GO:0006464 ! protein modification process [Term] id: GO:0018194 name: peptidyl-alanine modification namespace: biological_process def: "The modification of peptidyl-alanine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018195 name: peptidyl-arginine modification namespace: biological_process def: "The modification of peptidyl-arginine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018196 name: peptidyl-asparagine modification namespace: biological_process def: "The modification of peptidyl-asparagine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018197 name: peptidyl-aspartic acid modification namespace: biological_process def: "The modification of peptidyl-aspartic acid." [GOC:ma] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018198 name: peptidyl-cysteine modification namespace: biological_process def: "The modification of peptidyl-cysteine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018199 name: peptidyl-glutamine modification namespace: biological_process def: "The modification of peptidyl-glutamine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018200 name: peptidyl-glutamic acid modification namespace: biological_process def: "The modification of peptidyl-glutamic acid." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018201 name: peptidyl-glycine modification namespace: biological_process def: "The modification of peptidyl-glycine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018202 name: peptidyl-histidine modification namespace: biological_process def: "The modification of peptidyl-histidine." [GOC:ma] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018203 name: peptidyl-isoleucine modification namespace: biological_process def: "The modification of peptidyl-isoleucine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018204 name: peptidyl-leucine modification namespace: biological_process def: "The modification of peptidyl-leucine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018205 name: peptidyl-lysine modification namespace: biological_process def: "The modification of peptidyl-lysine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018206 name: peptidyl-methionine modification namespace: biological_process def: "The modification of peptidyl-methionine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018207 name: peptidyl-phenylalanine modification namespace: biological_process def: "The modification of peptidyl-phenylalanine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018208 name: peptidyl-proline modification namespace: biological_process def: "The modification of peptidyl-proline." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018209 name: peptidyl-serine modification namespace: biological_process def: "The modification of peptidyl-serine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018210 name: peptidyl-threonine modification namespace: biological_process def: "The modification of peptidyl-threonine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018211 name: peptidyl-tryptophan modification namespace: biological_process def: "The chemical alteration of a tryptophan residue in a peptide." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018212 name: peptidyl-tyrosine modification namespace: biological_process def: "The modification of peptidyl-tyrosine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018213 name: peptidyl-valine modification namespace: biological_process def: "The modification of peptidyl-valine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018214 name: protein carboxylation namespace: biological_process def: "The addition of a carboxy group to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid carboxylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018215 name: protein phosphopantetheinylation namespace: biological_process def: "The modification of a protein amino acid by phosphopantetheinylation." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid phosphopantetheinylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018216 name: peptidyl-arginine methylation namespace: biological_process alt_id: GO:0018017 def: "The addition of a methyl group to an arginine residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006479 ! protein methylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018217 name: peptidyl-aspartic acid phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-aspartic acid." [GOC:jl] subset: gosubset_prok is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0018218 name: peptidyl-cysteine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine." [RESID:AA0034] subset: gosubset_prok xref: RESID:AA0034 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018219 name: peptidyl-cysteine S-acetylation namespace: biological_process def: "The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine." [RESID:AA0056] subset: gosubset_prok xref: RESID:AA0056 is_a: GO:0018533 ! peptidyl-cysteine acetylation [Term] id: GO:0018220 name: peptidyl-threonine palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0079] comment: Palmitoylation of a non-terminal threonine residue always occurs on an oxygen (O) atom. subset: gosubset_prok synonym: "peptidyl-threonine O-palmitoylation" EXACT [GOC:jsg] xref: RESID:AA0079 is_a: GO:0018210 ! peptidyl-threonine modification is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0018221 name: peptidyl-serine palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine." [RESID:AA0080] comment: Palmitoylation of a non-terminal serine residue always occurs on an oxygen (O) atom. subset: gosubset_prok synonym: "peptidyl-serine O-palmitoylation" EXACT [GOC:jsg] xref: RESID:AA0080 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0018222 name: peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide." [RESID:AA0101] subset: gosubset_prok synonym: "peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine" EXACT [] xref: RESID:AA0101 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018226 name: peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic." [RESID:AA0102] subset: gosubset_prok synonym: "peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0102 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018343 ! protein farnesylation [Term] id: GO:0018227 name: peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine." [RESID:AA0103] subset: gosubset_prok synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0103 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018343 ! protein farnesylation [Term] id: GO:0018228 name: peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification." [RESID:AA0104] subset: gosubset_prok synonym: "peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0104 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018344 ! protein geranylgeranylation [Term] id: GO:0018229 name: peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl ester." [RESID:AA0105] subset: gosubset_prok synonym: "peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0105 is_a: GO:0018351 ! peptidyl-cysteine esterification [Term] id: GO:0018230 name: peptidyl-L-cysteine S-palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine." [RESID:AA0106] comment: Palmitoylation of a non-terminal cysteine residue always occurs on a sulfur (S) atom. subset: gosubset_prok synonym: "peptidyl-cysteine S-palmitoylation" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0106 is_a: GO:0018231 ! peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0018231 name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107] subset: gosubset_prok synonym: "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0107 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018232 name: peptide cross-linking via S-(L-isoglutamyl)-L-cysteine namespace: biological_process def: "The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link." [RESID:AA0108] subset: gosubset_prok xref: RESID:AA0108 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0018233 name: peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link." [RESID:AA0109] subset: gosubset_prok xref: RESID:AA0109 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018234 name: peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine namespace: biological_process def: "The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase." [RESID:AA0113] subset: gosubset_prok xref: RESID:AA0113 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018235 name: peptidyl-lysine carboxylation namespace: biological_process def: "The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine." [RESID:AA0114] subset: gosubset_prok xref: RESID:AA0114 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018214 ! protein carboxylation [Term] id: GO:0018237 name: urease activator activity namespace: molecular_function def: "Increases the activity of urease by promoting the incorporation of nickel into the active site." [GOC:mah, PMID:16244137] synonym: "urease activase activity" EXACT [] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0018238 name: peptidyl-lysine carboxyethylation namespace: biological_process alt_id: GO:0018239 def: "The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine." [RESID:AA0115] subset: gosubset_prok synonym: "protein amino acid carboxyethylation" EXACT [] xref: RESID:AA0115 is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018240 name: protein S-linked glycosylation via cysteine namespace: biological_process def: "The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine." [RESID:AA0152] subset: gosubset_prok synonym: "protein amino acid S-linked glycosylation via cysteine" EXACT [GOC:bf] xref: RESID:AA0152 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018280 ! protein S-linked glycosylation [Term] id: GO:0018241 name: protein O-linked glycosylation via hydroxylysine namespace: biological_process def: "The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine." [RESID:AA0153] subset: gosubset_prok synonym: "protein amino acid O-linked glycosylation via hydroxylysine" EXACT [GOC:bf] xref: RESID:AA0153 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018242 name: protein O-linked glycosylation via serine namespace: biological_process def: "The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154] subset: gosubset_prok synonym: "protein amino acid O-linked glycosylation via serine" EXACT [GOC:bf] xref: RESID:AA0154 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018243 name: protein O-linked glycosylation via threonine namespace: biological_process def: "The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine." [RESID:AA0155] subset: gosubset_prok synonym: "protein amino acid O-linked glycosylation via threonine" EXACT [GOC:bf] xref: RESID:AA0155 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018244 name: protein N-linked glycosylation via tryptophan namespace: biological_process def: "The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue." [RESID:AA0156] subset: gosubset_prok synonym: "protein amino acid N-linked glycosylation via tryptophan" EXACT [GOC:bf] xref: RESID:AA0156 is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018245 name: protein O-linked glycosylation via tyrosine namespace: biological_process def: "The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen." [RESID:AA0157] subset: gosubset_prok synonym: "protein amino acid O-linked glycosylation via tyrosine" EXACT [GOC:bf] xref: RESID:AA0157 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018246 name: protein-coenzyme A linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah] subset: gosubset_prok is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018247 name: protein-phosphoribosyl dephospho-coenzyme A linkage namespace: biological_process def: "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position." [RESID:AA0167] subset: gosubset_prok xref: RESID:AA0167 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018246 ! protein-coenzyme A linkage [Term] id: GO:0018248 name: enzyme active site formation via S-sulfo-L-cysteine namespace: biological_process def: "The transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171] subset: gosubset_prok synonym: "enzyme active site formation via S-sulpho-L-cysteine" EXACT [] xref: RESID:AA0171 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018249 name: protein dehydration namespace: biological_process def: "The removal of a water group from a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid dehydration" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018250 name: peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine namespace: biological_process def: "The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG." [RESID:AA0181] subset: gosubset_prok synonym: "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine" EXACT [] synonym: "peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine" EXACT [] synonym: "peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine" EXACT [] xref: RESID:AA0181 is_a: GO:0018194 ! peptidyl-alanine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018249 ! protein dehydration is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0018251 name: peptidyl-tyrosine dehydrogenation namespace: biological_process def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues." [RESID:AA0183] comment: See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'. subset: gosubset_prok xref: RESID:AA0183 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018249 ! protein dehydration [Term] id: GO:0018252 name: peptide cross-linking via L-seryl-5-imidazolinone glycine namespace: biological_process def: "The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0184] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] xref: RESID:AA0184 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0018253 name: peptide cross-linking via 5-imidazolinone glycine namespace: biological_process def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde." [RESID:AA0184, RESID:AA0187, RESID:AA0188] subset: gosubset_prok synonym: "biosynthesis of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] xref: RESID:AA0184 xref: RESID:AA0187 xref: RESID:AA0188 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018254 name: peptidyl-tyrosine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine." [RESID:AA0203] subset: gosubset_prok synonym: "peptidyl-tyrosine adenylation" EXACT [] xref: RESID:AA0203 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018255 name: peptide cross-linking via S-glycyl-L-cysteine namespace: biological_process def: "The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins." [RESID:AA0206] subset: gosubset_prok xref: RESID:AA0206 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018256 name: protein formylation namespace: biological_process def: "The addition of a formyl group to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid formylation" EXACT [GOC:bf] is_a: GO:0043543 ! protein acylation [Term] id: GO:0018257 name: peptidyl-lysine formylation namespace: biological_process def: "The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine." [RESID:AA0211] subset: gosubset_prok xref: RESID:AA0211 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018256 ! protein formylation [Term] id: GO:0018258 name: protein O-linked glycosylation via hydroxyproline namespace: biological_process def: "The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline." [RESID:AA0212] subset: gosubset_prok synonym: "protein amino acid O-linked glycosylation via hydroxyproline" EXACT [GOC:bf] xref: RESID:AA0212 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0018259 name: RNA-protein covalent cross-linking via peptidyl-serine namespace: biological_process def: "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine." [RESID:AA0213] subset: gosubset_prok xref: RESID:AA0213 is_a: GO:0018144 ! RNA-protein covalent cross-linking is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018260 name: protein guanylylation namespace: biological_process def: "The addition of phospho-guanosine to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid guanylylation" EXACT [GOC:bf] is_a: GO:0018175 ! protein nucleotidylation [Term] id: GO:0018261 name: peptidyl-lysine guanylylation namespace: biological_process def: "The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine." [RESID:AA0228] subset: gosubset_prok xref: RESID:AA0228 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018260 ! protein guanylylation [Term] id: GO:0018262 name: isopeptide cross-linking namespace: biological_process def: "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon." [GOC:jsg] subset: gosubset_prok is_a: GO:0018149 ! peptide cross-linking [Term] id: GO:0018263 name: isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine." [RESID:AA0216] subset: gosubset_prok xref: RESID:AA0216 is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0018264 name: isopeptide cross-linking via N-(L-isoaspartyl)-glycine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine." [RESID:AA0126] subset: gosubset_prok xref: RESID:AA0126 is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0018265 name: GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0158] subset: gosubset_prok synonym: "GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0158 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018266 name: GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0159] subset: gosubset_prok synonym: "GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0159 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0018267 name: GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0160] subset: gosubset_prok synonym: "GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0160 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018268 name: GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0161] subset: gosubset_prok synonym: "GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0161 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018269 name: GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0162] subset: gosubset_prok synonym: "GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0162 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018270 name: GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0163] subset: gosubset_prok synonym: "GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0163 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0018271 name: biotin-protein ligase activity namespace: molecular_function alt_id: GO:0000106 def: "Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah] subset: gosubset_prok synonym: "biotin-apoprotein ligase activity" EXACT [] xref: EC:6.3.4.- xref: MetaCyc:BIOTINLIG-RXN is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0018272 name: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine." [RESID:AA0119] subset: gosubset_prok xref: RESID:AA0119 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018352 ! protein-pyridoxal-5-phosphate linkage [Term] id: GO:0018273 name: protein-chromophore linkage via peptidyl-N6-retinal-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form N6-retinal-L-lysine." [RESID:AA0120] subset: gosubset_prok xref: RESID:AA0120 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0018274 name: peptide cross-linking via L-lysinoalanine namespace: biological_process def: "The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link." [RESID:AA0123] subset: gosubset_prok xref: RESID:AA0123 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018275 name: N-terminal peptidyl-cysteine acetylation namespace: biological_process alt_id: GO:0017191 def: "The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine." [RESID:AA0043] subset: gosubset_prok synonym: "peptidyl-cysteine N-acetylation" EXACT [] xref: RESID:AA0043 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018533 ! peptidyl-cysteine acetylation [Term] id: GO:0018276 name: isopeptide cross-linking via N6-glycyl-L-lysine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination." [RESID:AA0125] comment: See also the biological process term 'peptide cross-linking via S-glycyl-L-cysteine ; GO:0018255'. xref: RESID:AA0125 is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018262 ! isopeptide cross-linking relationship: part_of GO:0016567 ! protein ubiquitination [Term] id: GO:0018277 name: protein deamination namespace: biological_process def: "The removal of an amino group from a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid deamination" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018278 name: N-terminal peptidyl-threonine deamination namespace: biological_process def: "The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid." [RESID:AA0129] subset: gosubset_prok xref: RESID:AA0129 is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018279 name: protein N-linked glycosylation via asparagine namespace: biological_process def: "The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421] subset: gosubset_prok synonym: "protein amino acid N-linked glycosylation via asparagine" EXACT [GOC:bf] xref: Reactome:1253314 "Synthesis of dolichyl-phosphate mannose" xref: Reactome:1253317 "Asparagine N-linked glycosylation" xref: Reactome:1253774 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1280252 "Synthesis of dolichyl-phosphate mannose" xref: Reactome:1280255 "Asparagine N-linked glycosylation" xref: Reactome:1280707 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1299111 "Synthesis of dolichyl-phosphate mannose" xref: Reactome:1299114 "Asparagine N-linked glycosylation" xref: Reactome:1299530 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1326830 "Synthesis of dolichyl-phosphate mannose" xref: Reactome:1326833 "Asparagine N-linked glycosylation" xref: Reactome:1327291 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1353167 "Asparagine N-linked glycosylation" xref: Reactome:1353388 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1373345 "Asparagine N-linked glycosylation" xref: Reactome:1373560 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1393367 "Asparagine N-linked glycosylation" xref: Reactome:1393576 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1417636 "Synthesis of dolichyl-phosphate mannose" xref: Reactome:1417639 "Asparagine N-linked glycosylation" xref: Reactome:1418083 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1450953 "Asparagine N-linked glycosylation" xref: Reactome:1451172 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1471334 "Asparagine N-linked glycosylation" xref: Reactome:1471515 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1483302 "Asparagine N-linked glycosylation" xref: Reactome:1483455 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1496986 "Asparagine N-linked glycosylation" xref: Reactome:1497094 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1514373 "Asparagine N-linked glycosylation" xref: Reactome:1514481 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1521121 "Synthesis of dolichyl-phosphate mannose" xref: Reactome:1521124 "Asparagine N-linked glycosylation" xref: Reactome:1521350 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1526964 "Asparagine N-linked glycosylation" xref: Reactome:1527045 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1532700 "Asparagine N-linked glycosylation" xref: Reactome:1532777 "Synthesis of dolichyl-phosphate-glucose" xref: Reactome:1536106 "Asparagine N-linked glycosylation" xref: Reactome:162699 "Synthesis of dolichyl-phosphate mannose" xref: Reactome:446203 "Asparagine N-linked glycosylation" xref: Reactome:480985 "Synthesis of dolichyl-phosphate-glucose" is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018280 name: protein S-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a sugar unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine." [GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "protein amino acid S-linked glycosylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0018281 name: GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine namespace: biological_process def: "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0166] subset: gosubset_prok synonym: "GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] xref: RESID:AA0166 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0042082 ! GSI anchor biosynthetic process [Term] id: GO:0018282 name: metal incorporation into metallo-sulfur cluster namespace: biological_process def: "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide." [GOC:jsg] subset: gosubset_prok synonym: "metal incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0006464 ! protein modification process relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly [Term] id: GO:0018283 name: iron incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of iron into a metallo-sulfur cluster." [GOC:ai] subset: gosubset_prok synonym: "iron incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018284 name: iron incorporation into protein via tetrakis-L-cysteinyl iron namespace: biological_process def: "The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein)." [RESID:AA0136] subset: gosubset_prok xref: RESID:AA0136 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018285 name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide namespace: biological_process def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide." [RESID:AA0137] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide" EXACT [] xref: RESID:AA0137 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018286 name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide namespace: biological_process def: "OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form." [RESID:AA0138] comment: This term was made obsolete because the three-iron three-sulfur cluster is now thought not to exist except possibly as an intermediate form. synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron trisulphide" EXACT [] is_obsolete: true consider: GO:0018198 consider: GO:0018283 [Term] id: GO:0018287 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide namespace: biological_process def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide." [RESID:AA0139] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide" EXACT [] xref: RESID:AA0139 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018288 name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide." [RESID:AA0140] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide" EXACT [] xref: RESID:AA0140 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018289 name: molybdenum incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of molybdenum into a metallo-sulfur cluster." [GOC:ai] subset: gosubset_prok synonym: "molybdenum incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018290 name: iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide namespace: biological_process def: "The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase." [RESID:AA0141] subset: gosubset_prok synonym: "iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide" EXACT [] xref: RESID:AA0141 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster is_a: GO:0018291 ! molybdenum incorporation into iron-sulfur cluster [Term] id: GO:0018291 name: molybdenum incorporation into iron-sulfur cluster namespace: biological_process def: "The incorporation of molybdenum into an iron-sulfur cluster." [GOC:ai] subset: gosubset_prok synonym: "molybdenum incorporation into iron-sulphur cluster" EXACT [] is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018289 ! molybdenum incorporation into metallo-sulfur cluster [Term] id: GO:0018292 name: molybdenum incorporation via L-cysteinyl molybdopterin namespace: biological_process def: "The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin." [RESID:AA0142] subset: gosubset_prok xref: RESID:AA0142 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0018293 name: protein-FAD linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai] subset: gosubset_prok is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018294 name: protein-FAD linkage via S-(8alpha-FAD)-L-cysteine namespace: biological_process def: "The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine." [RESID:AA0143] subset: gosubset_prok xref: RESID:AA0143 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018295 name: protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine namespace: biological_process def: "The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine." [RESID:AA0144] subset: gosubset_prok xref: RESID:AA0144 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018296 name: protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine namespace: biological_process def: "The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine." [RESID:AA0145] subset: gosubset_prok xref: RESID:AA0145 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018297 name: protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine namespace: biological_process def: "The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine." [RESID:AA0221] subset: gosubset_prok xref: RESID:AA0221 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018298 name: protein-chromophore linkage namespace: biological_process def: "The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma] subset: gosubset_prok is_a: GO:0006464 ! protein modification process [Term] id: GO:0018299 name: iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide namespace: biological_process def: "The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide." [RESID:AA0225] subset: gosubset_prok synonym: "iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide" EXACT [] xref: RESID:AA0225 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018300 name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide namespace: biological_process def: "OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide." [RESID:AA0226] comment: This term was made obsolete because the prismane 6Fe-6S cluster is now thought not to exist. synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide" EXACT [] is_obsolete: true consider: GO:0018198 consider: GO:0018283 [Term] id: GO:0018301 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon namespace: biological_process def: "The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon." [RESID:AA0268] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon" EXACT [] xref: RESID:AA0268 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018302 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide." [RESID:AA0284] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide" EXACT [] xref: RESID:AA0284 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018303 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide." [RESID:AA0285] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide" EXACT [] xref: RESID:AA0285 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018304 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide." [RESID:AA0286] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide" EXACT [] xref: RESID:AA0286 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018305 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide." [RESID:AA0288] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide" EXACT [] xref: RESID:AA0288 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018306 name: iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide." [RESID:AA0289] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide" EXACT [] xref: RESID:AA0289 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018307 name: enzyme active site formation namespace: biological_process def: "The modification of part of an enzyme to form the active site." [GOC:ai] subset: gosubset_prok is_a: GO:0006464 ! protein modification process [Term] id: GO:0018308 name: enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine namespace: biological_process def: "OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase." [PMID:1463470, RESID:AA0287] comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. is_obsolete: true [Term] id: GO:0018309 name: protein-FMN linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah] subset: gosubset_prok is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018310 name: protein-FMN linkage via S-(6-FMN)-L-cysteine namespace: biological_process def: "The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine." [RESID:AA0220] subset: gosubset_prok xref: RESID:AA0220 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0018311 name: peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine." [RESID:AA0236] subset: gosubset_prok synonym: "peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine" EXACT [] synonym: "peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine" EXACT [] synonym: "peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine" EXACT [] xref: RESID:AA0236 is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018312 name: peptidyl-serine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine." [RESID:AA0237] subset: gosubset_prok xref: RESID:AA0237 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018313 name: peptide cross-linking via L-alanyl-5-imidazolinone glycine namespace: biological_process def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0187] subset: gosubset_prok xref: RESID:AA0187 is_a: GO:0018194 ! peptidyl-alanine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine [Term] id: GO:0018314 name: protein-pyrroloquinoline-quinone linkage namespace: biological_process def: "OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine." [PMID:7665488, RESID:AA0283] is_obsolete: true replaced_by: GO:0006464 [Term] id: GO:0018315 name: molybdenum incorporation into molybdenum-molybdopterin complex namespace: biological_process alt_id: GO:0042041 def: "The incorporation of molybdenum into a molybdenum-molybdopterin complex." [GOC:ai] subset: gosubset_prok synonym: "molybdenum incorporation into metallo-pterin complex" EXACT [] is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex [Term] id: GO:0018316 name: peptide cross-linking via L-cystine namespace: biological_process def: "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain." [RESID:AA0025] subset: gosubset_prok xref: RESID:AA0025 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018317 name: protein C-linked glycosylation via tryptophan namespace: biological_process def: "The glycosylation of a carbon atom of a peptidyl-tryptophan residue." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid C-linked glycosylation via tryptophan" EXACT [GOC:bf] is_a: GO:0018103 ! protein C-linked glycosylation is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018320 name: enzyme active site formation via S-methyl-L-cysteine namespace: biological_process def: "The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine." [RESID:AA0234] subset: gosubset_prok xref: RESID:AA0234 is_a: GO:0018125 ! peptidyl-cysteine methylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018321 name: protein glucuronylation namespace: biological_process def: "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid glucuronylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0018322 name: protein tyrosinylation namespace: biological_process def: "The addition of a tyrosine molecule to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid tyrosinylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018323 name: enzyme active site formation via L-cysteine sulfinic acid namespace: biological_process def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid." [RESID:AA0262] subset: gosubset_prok synonym: "enzyme active site formation via L-cysteine sulphinic acid" EXACT [] xref: RESID:AA0262 is_a: GO:0018171 ! peptidyl-cysteine oxidation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018324 name: enzyme active site formation via L-cysteine sulfenic acid namespace: biological_process def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase." [PMID:2501303, RESID:AA0205] subset: gosubset_prok synonym: "enzyme active site formation via L-cysteine sulphenic acid" EXACT [] xref: RESID:AA0205 is_a: GO:0018171 ! peptidyl-cysteine oxidation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018325 name: enzyme active site formation via S-phospho-L-cysteine namespace: biological_process def: "The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine." [RESID:AA0034] subset: gosubset_prok xref: RESID:AA0034 is_a: GO:0018218 ! peptidyl-cysteine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018326 name: enzyme active site formation via S-acetyl-L-cysteine namespace: biological_process def: "The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine." [RESID:AA0056] subset: gosubset_prok xref: RESID:AA0056 is_a: GO:0018219 ! peptidyl-cysteine S-acetylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018327 name: enzyme active site formation via 1'-phospho-L-histidine namespace: biological_process def: "The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine)." [RESID:AA0035] subset: gosubset_prok xref: RESID:AA0035 is_a: GO:0018106 ! peptidyl-histidine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018328 name: enzyme active site formation via 3'-phospho-L-histidine namespace: biological_process def: "The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0036] subset: gosubset_prok xref: RESID:AA0036 is_a: GO:0018106 ! peptidyl-histidine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018329 name: enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine namespace: biological_process def: "The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase." [RESID:AA0227] subset: gosubset_prok xref: RESID:AA0227 is_a: GO:0018116 ! peptidyl-lysine adenylylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018330 name: enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine namespace: biological_process def: "The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme." [RESID:AA0228] subset: gosubset_prok xref: RESID:AA0228 is_a: GO:0018261 ! peptidyl-lysine guanylylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018331 name: enzyme active site formation via O-phospho-L-serine namespace: biological_process def: "The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine." [RESID:AA0037] subset: gosubset_prok xref: RESID:AA0037 is_a: GO:0018105 ! peptidyl-serine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018332 name: enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine namespace: biological_process def: "The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I." [RESID:AA0267] subset: gosubset_prok xref: RESID:AA0267 is_a: GO:0018178 ! peptidyl-threonine adenylylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018333 name: enzyme active site formation via O-phospho-L-threonine namespace: biological_process def: "The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine." [RESID:AA0038] subset: gosubset_prok xref: RESID:AA0038 is_a: GO:0018107 ! peptidyl-threonine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018334 name: enzyme active site formation via O4'-phospho-L-tyrosine namespace: biological_process def: "The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine." [RESID:AA0039] subset: gosubset_prok xref: RESID:AA0039 is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018335 name: protein succinylation namespace: biological_process def: "The modification of a protein amino acid by succinylation." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid succinylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018336 name: peptidyl-tyrosine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine." [GOC:ai] subset: gosubset_prok is_a: GO:0018126 ! protein hydroxylation [Term] id: GO:0018337 name: enzyme active site formation via L-2',4',5'-topaquinone namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. is_obsolete: true [Term] id: GO:0018338 name: protein amino acid cinnamylation namespace: biological_process def: "OBSOLETE. The modification of a protein amino acid by cinnamylation." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0018097 [Term] id: GO:0018339 name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid namespace: biological_process def: "The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232] subset: gosubset_prok synonym: "peptidyl-aspartic acid methylthiolation" EXACT [] synonym: "peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] xref: RESID:AA0232 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018340 name: peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine namespace: biological_process def: "The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine." [RESID:AA0264] subset: gosubset_prok synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine" EXACT [] synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine" EXACT [] synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine" EXACT [] xref: RESID:AA0264 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018341 name: peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine." [PSI-MOD:00292] subset: gosubset_prok synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis" EXACT [] is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018342 name: protein prenylation namespace: biological_process alt_id: GO:0018346 def: "The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "C-terminal protein prenylation" NARROW [] synonym: "protein amino acid prenylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018343 name: protein farnesylation namespace: biological_process alt_id: GO:0018347 def: "The covalent attachment of a farnesyl group to a protein." [GOC:jl] subset: gosubset_prok synonym: "C-terminal protein farnesylation" NARROW [] synonym: "protein amino acid farnesylation" EXACT [GOC:bf] is_a: GO:0018342 ! protein prenylation [Term] id: GO:0018344 name: protein geranylgeranylation namespace: biological_process alt_id: GO:0018348 def: "The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl] subset: gosubset_prok synonym: "C-terminal protein geranylgeranylation" NARROW [] synonym: "protein amino acid geranylgeranylation" EXACT [GOC:bf] is_a: GO:0018342 ! protein prenylation [Term] id: GO:0018345 name: protein palmitoylation namespace: biological_process alt_id: GO:0018318 alt_id: GO:0018349 def: "The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806] subset: gosubset_prok synonym: "protein amino acid palmitoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0018350 name: protein esterification namespace: biological_process def: "The addition of an ester group to a protein amino acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid esterification" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018351 name: peptidyl-cysteine esterification namespace: biological_process def: "The addition of an ester group to a cysteine residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0018352 name: protein-pyridoxal-5-phosphate linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate." [GOC:mah] subset: gosubset_prok is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018353 name: protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine namespace: biological_process alt_id: GO:0018380 def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine." [RESID:AA0131] subset: gosubset_prok xref: RESID:AA0131 is_a: GO:0017009 ! protein-phycocyanobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018355 name: protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine namespace: biological_process def: "The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [RESID:AA00167] subset: gosubset_prok is_a: GO:0018247 ! protein-phosphoribosyl dephospho-coenzyme A linkage [Term] id: GO:0018356 name: protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine namespace: biological_process alt_id: GO:0018382 def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine." [RESID:AA0258] subset: gosubset_prok xref: RESID:AA0258 is_a: GO:0017008 ! protein-phycobiliviolin linkage [Term] id: GO:0018357 name: protein-phycourobilin linkage via phycourobilin-bis-L-cysteine namespace: biological_process alt_id: GO:0018383 def: "The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine." [RESID:AA0260] subset: gosubset_prok xref: RESID:AA0260 is_a: GO:0017010 ! protein-phycourobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018358 name: protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine namespace: biological_process alt_id: GO:0018381 def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine." [RESID:AA0133] subset: gosubset_prok xref: RESID:AA0133 is_a: GO:0017012 ! protein-phytochromobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018359 name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine namespace: biological_process alt_id: GO:0018385 def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine." [RESID:AA0266] subset: gosubset_prok synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine" EXACT [] xref: RESID:AA0266 is_a: GO:0018174 ! protein-heme P460 linkage is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018360 name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine namespace: biological_process alt_id: GO:0018384 def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine." [RESID:AA0271] subset: gosubset_prok synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine" EXACT [] xref: RESID:AA0271 is_a: GO:0018174 ! protein-heme P460 linkage is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018361 name: peptidyl-glutamine 2-methylation namespace: biological_process def: "The methylation of glutamine to form 2-methyl-L-glutamine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0273] subset: gosubset_prok xref: RESID:AA0273 is_a: GO:0018364 ! peptidyl-glutamine methylation [Term] id: GO:0018362 name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester namespace: biological_process alt_id: GO:0019924 def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester." [RESID:AA0279] subset: gosubset_prok synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester" EXACT [] xref: RESID:AA0279 is_a: GO:0018186 ! peroxidase-heme linkage is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018363 name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium namespace: biological_process alt_id: GO:0019925 def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium." [RESID:AA0280] subset: gosubset_prok synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium" EXACT [] synonym: "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium" EXACT [] xref: RESID:AA0280 is_a: GO:0018186 ! peroxidase-heme linkage is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018364 name: peptidyl-glutamine methylation namespace: biological_process def: "The addition of a methyl group to a glutamine residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006479 ! protein methylation [Term] id: GO:0018365 name: protein-serine epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5.1.1.16] synonym: "protein-serine racemase activity" EXACT [EC:5.1.1.16] xref: EC:5.1.1.16 xref: MetaCyc:5.1.1.16-RXN is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0018366 name: chiral amino acid racemization namespace: biological_process def: "The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid." [GOC:jsg, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0018367 name: free L-amino acid racemization namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is not clear that this process occurs. is_obsolete: true consider: GO:0006520 [Term] id: GO:0018376 name: peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine namespace: biological_process def: "The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0026] comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. subset: gosubset_prok xref: RESID:AA0026 is_a: GO:0042265 ! peptidyl-asparagine hydroxylation [Term] id: GO:0018377 name: protein myristoylation namespace: biological_process alt_id: GO:0018319 def: "The covalent attachment of a myristoyl group to a protein." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid myristoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0018378 name: cytochrome c-heme linkage via heme-L-cysteine namespace: biological_process def: "The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine." [RESID:AA0135] subset: gosubset_prok synonym: "cytochrome c-haem linkage via haem-L-cysteine" EXACT [] xref: RESID:AA0135 is_a: GO:0018063 ! cytochrome c-heme linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018379 name: cytochrome c-heme linkage via heme-bis-L-cysteine namespace: biological_process def: "The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine." [RESID:AA0134] subset: gosubset_prok synonym: "cytochrome c-haem linkage via haem-bis-L-cysteine" EXACT [] xref: RESID:AA0134 is_a: GO:0018063 ! cytochrome c-heme linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018386 name: N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine namespace: biological_process def: "The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine." [RESID:AA0274] subset: gosubset_prok xref: RESID:AA0274 is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018387 name: N-terminal peptidyl-amino acid deamination to pyruvic acid namespace: biological_process def: "The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] subset: gosubset_prok xref: RESID:AA0127 is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018388 name: N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine namespace: biological_process def: "The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine." [RESID:AA0275] subset: gosubset_prok xref: RESID:AA0275 is_a: GO:0018213 ! peptidyl-valine modification is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018389 name: N-terminal peptidyl-valine deamination namespace: biological_process def: "The deamination of the N-terminal valine residue of a protein to form isobutyrate." [GOC:ma, GOC:mah] subset: gosubset_prok is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018390 name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine namespace: biological_process def: "The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester." [RESID:AA0072] subset: gosubset_prok synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] xref: RESID:AA0072 is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018442 ! peptidyl-glutamic acid esterification [Term] id: GO:0018391 name: C-terminal peptidyl-glutamic acid tyrosinylation namespace: biological_process def: "The ATP-dependent addition of a tyrosine residue to a glutamic acid residue at the C-terminus of a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0018166 ! C-terminal protein-tyrosinylation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018392 name: glycoprotein 3-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24447] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity" EXACT [] synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] xref: EC:2.4.1.214 xref: KEGG:R06015 xref: MetaCyc:2.4.1.214-RXN xref: RHEA:24447 is_a: GO:0046920 ! alpha(1,3)-fucosyltransferase activity [Term] id: GO:0018393 name: internal peptidyl-lysine acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006475 ! internal protein amino acid acetylation is_a: GO:0018394 ! peptidyl-lysine acetylation [Term] id: GO:0018394 name: peptidyl-lysine acetylation namespace: biological_process def: "The acetylation of peptidyl-lysine." [GOC:mah] subset: gosubset_prok is_a: GO:0006473 ! protein acetylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018395 name: peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine namespace: biological_process def: "The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine." [RESID:AA0028] subset: gosubset_prok xref: RESID:AA0028 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0018396 name: peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine namespace: biological_process def: "The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine." [RESID:AA0235] subset: gosubset_prok xref: RESID:AA0235 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0018397 name: peptidyl-phenylalanine bromination to L-2'-bromophenylalanine namespace: biological_process def: "The bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine." [RESID:AA0174] subset: gosubset_prok xref: RESID:AA0174 is_a: GO:0018075 ! peptidyl-phenylalanine bromination [Term] id: GO:0018398 name: peptidyl-phenylalanine bromination to L-3'-bromophenylalanine namespace: biological_process def: "The bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine." [RESID:AA0175] subset: gosubset_prok xref: RESID:AA0175 is_a: GO:0018075 ! peptidyl-phenylalanine bromination [Term] id: GO:0018399 name: peptidyl-phenylalanine bromination to L-4'-bromophenylalanine namespace: biological_process def: "The bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine." [RESID:AA0176] subset: gosubset_prok xref: RESID:AA0176 is_a: GO:0018075 ! peptidyl-phenylalanine bromination [Term] id: GO:0018400 name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline namespace: biological_process def: "The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase." [RESID:AA0029] comment: See also the molecular function term 'procollagen-proline 3-dioxygenase activity ; GO:0019797'. subset: gosubset_prok xref: RESID:AA0029 is_a: GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0018401 name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline namespace: biological_process def: "The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030] comment: See also the molecular function term 'procollagen-proline 4-dioxygenase activity ; GO:0004656'. subset: gosubset_prok xref: RESID:AA0030 is_a: GO:0019471 ! 4-hydroxyproline metabolic process is_a: GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0018402 name: protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine namespace: biological_process def: "Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0208] subset: gosubset_prok synonym: "protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] xref: RESID:AA0208 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030204 ! chondroitin sulfate metabolic process [Term] id: GO:0018403 name: protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine namespace: biological_process def: "Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [PMID:7338506, RESID:AA0209] subset: gosubset_prok synonym: "protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] xref: RESID:AA0209 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018404 name: protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine namespace: biological_process def: "Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0210] subset: gosubset_prok synonym: "protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] xref: RESID:AA0210 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018405 name: protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine namespace: biological_process def: "Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." [RESID:AA0247] subset: gosubset_prok synonym: "protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT [] xref: RESID:AA0247 is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018406 name: protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan namespace: biological_process alt_id: GO:0032004 def: "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217] synonym: "protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan" EXACT [GOC:bf] synonym: "protein amino acid C-linked mannosylation" EXACT [] xref: RESID:AA0217 is_a: GO:0018317 ! protein C-linked glycosylation via tryptophan is_a: GO:0035268 ! protein mannosylation [Term] id: GO:0018407 name: peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine namespace: biological_process def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine)." [RESID:AA0177] subset: gosubset_prok synonym: "peptidyl-thyronine iodination to form triiodothyronine" BROAD [] xref: RESID:AA0177 is_a: GO:0018078 ! peptidyl-thyronine iodination [Term] id: GO:0018408 name: peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine namespace: biological_process def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine)." [RESID:AA0178] subset: gosubset_prok xref: RESID:AA0178 is_a: GO:0018078 ! peptidyl-thyronine iodination [Term] id: GO:0018410 name: C-terminal protein amino acid modification namespace: biological_process def: "The alteration of the C-terminal amino acid residue in a protein." [GOC:mah] subset: gosubset_prok synonym: "peptide or protein carboxyl-terminal blocking" RELATED [] synonym: "peptide/protein carboxyl-terminal blocking" RELATED [] is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0018411 name: protein glucuronidation namespace: biological_process def: "The modification of a protein by amino acid glucuronidation." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid glucuronidation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0018412 name: protein O-glucuronidation namespace: biological_process def: "The modification of a protein by glucuronidation on an amino acid oxygen atom." [GOC:mah] subset: gosubset_prok synonym: "protein amino acid O-glucuronidation" EXACT [GOC:bf] is_a: GO:0018411 ! protein glucuronidation [Term] id: GO:0018413 name: peptidyl-serine O-glucuronidation namespace: biological_process def: "The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine." [RESID:AA0291] subset: gosubset_prok xref: RESID:AA0291 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018412 ! protein O-glucuronidation [Term] id: GO:0018414 name: nickel incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of nickel into a metallo-sulfur cluster." [GOC:ai] subset: gosubset_prok synonym: "nickel incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018415 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0292 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018416 name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] subset: gosubset_prok synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0292 is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster [Term] id: GO:0018417 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0293 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018418 name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] subset: gosubset_prok synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0 is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster [Term] id: GO:0018419 name: protein catenane formation namespace: biological_process def: "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0018420 name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine namespace: biological_process def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues." [RESID:AA0294] subset: gosubset_prok xref: RESID:AA0294 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018421 name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:9353330] xref: EC:2.7.8.- is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0018422 name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:10037765] xref: EC:2.7.8.- is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0018423 name: protein C-terminal leucine carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [PMID:8514774] synonym: "protein phosphatase methyltransferase activity" NARROW [] synonym: "protein-leucine O-methyltransferase activity" EXACT [] xref: EC:2.1.1.- is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018424 name: peptidyl-glutamic acid poly-ADP-ribosylation namespace: biological_process def: "This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way." [RESID:AA0295] subset: gosubset_prok xref: RESID:AA0295 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018425 name: O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds." [RESID:AA0296] subset: gosubset_prok synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism" EXACT [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis" EXACT [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation" EXACT [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis" EXACT [] xref: RESID:AA0296 is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0018426 name: O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage." [RESID:AA0297] subset: gosubset_prok synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism" EXACT [] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis" EXACT [] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation" EXACT [] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis" EXACT [] xref: RESID:AA0297 is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine [Term] id: GO:0018427 name: copper incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of copper into a metallo-sulfur cluster." [GOC:ai] subset: gosubset_prok synonym: "copper incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018428 name: copper incorporation into copper-sulfur cluster namespace: biological_process def: "The incorporation of copper into a copper-sulfur cluster." [GOC:ai] subset: gosubset_prok synonym: "copper incorporation into copper-sulphur cluster" EXACT [] is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster [Term] id: GO:0018429 name: copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide namespace: biological_process def: "The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [RESID:AA0298] subset: gosubset_prok synonym: "copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide" EXACT [] xref: RESID:AA0298 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018428 ! copper incorporation into copper-sulfur cluster [Term] id: GO:0018439 name: peptidyl-leucine esterification namespace: biological_process alt_id: GO:0018440 def: "The chemical reactions and pathways resulting in the formation of peptidyl-L-leucine methyl ester." [RESID:AA0299] subset: gosubset_prok xref: RESID:AA0299 is_a: GO:0018203 ! peptidyl-isoleucine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0018441 name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide namespace: biological_process def: "The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase." [PMID:9063865, RESID:AA0300] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide" EXACT [] xref: RESID:AA0300 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster is_a: GO:0018418 ! nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide [Term] id: GO:0018442 name: peptidyl-glutamic acid esterification namespace: biological_process def: "The addition of an ester group to a glutamic acid residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0018443 name: enzyme active site formation via L-aspartic 4-phosphoric anhydride namespace: biological_process def: "The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride." [RESID:AA0033] subset: gosubset_prok xref: RESID:AA0033 is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018444 name: translation release factor complex namespace: cellular_component def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] synonym: "eukaryotic peptide chain release factor" EXACT [] synonym: "peptide chain release factor" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0018445 name: prothoracicotrophic hormone activity namespace: molecular_function def: "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0018446 name: pinocarveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0717] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r0717 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018447 name: chloral hydrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol." [UM-BBD_enzymeID:e0229] xref: EC:1.1.-.- xref: UM-BBD_enzymeID:e0229 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018448 name: hydroxymethylmethylsilanediol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [UM-BBD_reactionID:r0638] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r0638 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018449 name: 1-phenylethanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2." [UM-BBD_reactionID:r0032] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r0032 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018450 name: myrtenol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [UM-BBD_reactionID:r0710] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r0710 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018451 name: epoxide dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [UM-BBD_reactionID:r0595] xref: EC:1.1.1.- xref: UM-BBD_reactionID:r0595 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018452 name: 5-exo-hydroxycamphor dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_reactionID:r0427] xref: EC:1.1.1.- xref: MetaCyc:R542-RXN xref: UM-BBD_reactionID:r0427 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018453 name: 2-hydroxytetrahydrofuran dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [UM-BBD_reactionID:r0018] xref: EC:1.1.1.- xref: UM-BBD_reactionID:r0018 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018454 name: acetoacetyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36] subset: gosubset_prok synonym: "(R)-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.36] synonym: "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.36] synonym: "acetoacetyl coenzyme A reductase activity" EXACT [EC:1.1.1.36] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.36] synonym: "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity" EXACT [EC:1.1.1.36] synonym: "D-3-hydroxyacyl-CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "hydroxyacyl coenzyme-A dehydrogenase activity" EXACT [EC:1.1.1.36] synonym: "NADP-linked acetoacetyl CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "NADPH:acetoacetyl-CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity" EXACT [EC:1.1.1.36] xref: EC:1.1.1.36 xref: MetaCyc:RXN-7698 xref: UM-BBD_reactionID:r0202 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018455 name: alcohol dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+." [EC:1.1.1.71] synonym: "alcohol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.71] synonym: "aldehyde reductase (NADPH/NADH)" EXACT [EC:1.1.1.71] xref: EC:1.1.1.71 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN xref: UM-BBD_reactionID:r0172 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018456 name: aryl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90] subset: gosubset_prok synonym: "aryl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.90] synonym: "benzyl alcohol dehydrogenase activity" NARROW [] synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90] xref: EC:1.1.1.90 xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0019 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018457 name: perillyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde." [EC:1.1.1.144, RHEA:10667] synonym: "perillyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.144] synonym: "perillyl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.144] xref: EC:1.1.1.144 xref: KEGG:R03945 xref: MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN xref: RHEA:10667 xref: UM-BBD_reactionID:r0729 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018458 name: isopiperitenol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD(+) = (6R)-isoperitenone + H(+) + NADH." [EC:1.1.1.223, RHEA:20863] synonym: "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.223] xref: EC:1.1.1.223 xref: KEGG:R03261 xref: MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN xref: RHEA:20863 xref: UM-BBD_reactionID:r0740 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018459 name: carveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH." [EC:1.1.1.243, RHEA:13632] synonym: "(-)-trans-carveol dehydrogenase activity" EXACT [EC:1.1.1.243] synonym: "(-)-trans-carveol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.243] xref: EC:1.1.1.243 xref: KEGG:R03114 xref: MetaCyc:CARVEOL-DEHYDROGENASE-RXN xref: RHEA:13632 xref: UM-BBD_reactionID:r0714 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018460 name: cyclohexanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+." [EC:1.1.1.245] synonym: "cyclohexanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.245] xref: EC:1.1.1.245 xref: MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0165 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018461 name: fluoren-9-ol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256] synonym: "9-fluorenol dehydrogenase activity" EXACT [] synonym: "fluoren-9-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.256] xref: EC:1.1.1.256 xref: MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0408 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018462 name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH." [EC:1.1.1.257, RHEA:24415] synonym: "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.257] synonym: "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity" EXACT [] synonym: "4-sulfobenzyl alcohol dehydrogenase activity" EXACT [] xref: EC:1.1.1.257 xref: KEGG:R05271 xref: MetaCyc:1.1.1.257-RXN xref: RHEA:24415 xref: UM-BBD_reactionID:r0291 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018463 name: 6-hydroxyhexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH." [EC:1.1.1.258, RHEA:14228] synonym: "6-hydroxyhexanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.258] xref: EC:1.1.1.258 xref: KEGG:R05283 xref: MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN xref: RHEA:14228 xref: UM-BBD_reactionID:r0174 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018464 name: 3-hydroxypimeloyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD(+) = 3-oxopimelyl-CoA + H(+) + NADH." [EC:1.1.1.259, RHEA:11171] synonym: "3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.259] xref: EC:1.1.1.259 xref: KEGG:R05305 xref: MetaCyc:1.1.1.259-RXN xref: RHEA:11171 xref: UM-BBD_reactionID:r0196 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018465 name: vanillyl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + vanillyl alcohol = H(2)O(2) + vanillin." [EC:1.1.3.38, RHEA:10039] synonym: "4-hydroxy-2-methoxybenzyl alcohol oxidase activity" EXACT [EC:1.1.3.38] synonym: "vanillyl alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.38] xref: EC:1.1.3.38 xref: KEGG:R02877 xref: MetaCyc:1.1.3.38-RXN xref: RHEA:10039 xref: UM-BBD_reactionID:r0651 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0018466 name: limonene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_reactionID:r0735] xref: EC:1.1.99.- xref: UM-BBD_reactionID:r0735 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018467 name: formaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH." [EC:1.2.1.46, RHEA:16428] subset: gosubset_prok synonym: "formaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.46] synonym: "glutathione-independent formaldehyde dehydrogenase activity" EXACT [] xref: EC:1.2.1.46 xref: KEGG:R00604 xref: MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:16428 xref: UM-BBD_reactionID:r0240 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018468 name: alcohol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor." [EC:1.1.99.8] subset: gosubset_prok synonym: "alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.8] synonym: "alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.8] synonym: "MDH" RELATED [EC:1.1.99.8] synonym: "PQQ-dependent alcohol dehydrogenase activity" EXACT [] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.99.8] synonym: "quinohemoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] synonym: "quinoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] synonym: "quinoprotein ethanol dehydrogenase activity" EXACT [EC:1.1.99.8] xref: EC:1.1.99.8 xref: UM-BBD_enzymeID:e0004 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018469 name: myrtenal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [UM-BBD_reactionID:r0711] xref: EC:1.2.-.- xref: UM-BBD_reactionID:r0711 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018470 name: 4-hydroxybutaraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [UM-BBD_reactionID:r0014] xref: EC:1.2.-.- xref: UM-BBD_reactionID:r0014 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018471 name: 4-chlorobenzaldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0447] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0447 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018472 name: 1-hydroxy-2-naphthaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [UM-BBD_reactionID:r0485] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r0485 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018473 name: cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0744] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r0744 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018474 name: 2-carboxybenzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate." [UM-BBD_reactionID:r0490] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r0490 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018475 name: trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0745] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r0745 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018477 name: benzaldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+." [EC:1.2.1.7] synonym: "benzaldehyde:NADP+ oxidoreductase" EXACT [EC:1.2.1.7] synonym: "NADP-linked benzaldehyde dehydrogenase" EXACT [EC:1.2.1.7] xref: EC:1.2.1.7 xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN xref: UM-BBD_enzymeID:e0079 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018478 name: malonate-semialdehyde dehydrogenase (acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+." [EC:1.2.1.18] subset: gosubset_prok synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)" EXACT [EC:1.2.1.18] synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT [] xref: EC:1.2.1.18 xref: MetaCyc:1.2.1.18-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018479 name: benzaldehyde dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+." [EC:1.2.1.28] subset: gosubset_prok synonym: "benzaldehyde (NAD) dehydrogenase activity" EXACT [EC:1.2.1.28] synonym: "benzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.28] xref: EC:1.2.1.28 xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN xref: UM-BBD_reactionID:r0269 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018480 name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60] subset: gosubset_prok synonym: "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.60] synonym: "carboxymethylhydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.60] xref: EC:1.2.1.60 xref: MetaCyc:CHMS-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0365 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018481 name: 4-hydroxymuconic-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis,trans-4-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 2 H(+) + maleylacetate + NADH." [EC:1.2.1.61, RHEA:22423] subset: gosubset_prok synonym: "4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.61] xref: EC:1.2.1.61 xref: KEGG:R05236 xref: MetaCyc:1.2.1.61-RXN xref: RHEA:22423 xref: UM-BBD_reactionID:r0229 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018482 name: 4-formylbenzenesulfonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-formylbenzenesulfonate + H(2)O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH." [EC:1.2.1.62, RHEA:18836] synonym: "4-formylbenzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.62] synonym: "4-formylbenzenesulphonate dehydrogenase activity" EXACT [] synonym: "toluene-sulfonate aldehyde dehydrogenase activity" EXACT [] xref: EC:1.2.1.62 xref: KEGG:R05272 xref: MetaCyc:1.2.1.62-RXN xref: RHEA:18836 xref: UM-BBD_reactionID:r0292 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018483 name: 6-oxohexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+." [EC:1.2.1.63] synonym: "6-oxohexanoate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.63] xref: EC:1.2.1.63 xref: MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN xref: UM-BBD_reactionID:r0175 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018484 name: 4-hydroxybenzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64] synonym: "3-hydroxybenzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.64] synonym: "p-hydroxybenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.64] xref: EC:1.2.1.64 xref: MetaCyc:HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN xref: UM-BBD_reactionID:r0273 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018485 name: salicylaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+." [EC:1.2.1.65] subset: gosubset_prok synonym: "salicylaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.65] xref: EC:1.2.1.65 xref: MetaCyc:1.2.1.65-RXN xref: UM-BBD_enzymeID:e0256 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018486 name: 2-butanone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [UM-BBD_reactionID:r0169] xref: EC:1.2.3.- xref: UM-BBD_reactionID:r0169 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0018487 name: vanillate O-demethylase (anaerobic) activity namespace: molecular_function def: "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0758] xref: EC:1.2.3.- xref: UM-BBD_reactionID:r0758 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor is_a: GO:0032451 ! demethylase activity [Term] id: GO:0018488 name: aryl-aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide." [EC:1.2.3.9] synonym: "aryl-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.9] xref: EC:1.2.3.9 xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN xref: UM-BBD_reactionID:r0145 is_a: GO:0004031 ! aldehyde oxidase activity [Term] id: GO:0018489 name: vanillate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H(2)O + NAD(+)." [EC:1.14.13.82, RHEA:13024] comment: Note that this was EC:1.2.3.12. subset: gosubset_prok synonym: "4-hydroxy-3-methoxybenzoate demethylase activity" EXACT [EC:1.14.13.82] synonym: "vanillate demethylase (aerobic) activity" EXACT [] synonym: "vanillate demethylase activity" EXACT [] synonym: "vanillate:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.13.82] xref: EC:1.14.13.82 xref: KEGG:R05274 xref: MetaCyc:RXN-10891 xref: MetaCyc:RXN-2 xref: RHEA:13024 xref: UM-BBD_reactionID:r0146 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen is_a: GO:0032451 ! demethylase activity [Term] id: GO:0018490 name: 4-hydroxyphenylpyruvate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O(2) = 2 (4-hydroxyphenyl)acetate + 2 CO(2)." [EC:1.2.3.13, RHEA:17200] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.2.3.13] xref: EC:1.2.3.13 xref: KEGG:R00042 xref: MetaCyc:1.2.3.13-RXN xref: RHEA:17200 xref: UM-BBD_reactionID:r0299 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0018491 name: 2-oxobutyrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.2] synonym: "2-ketobutyrate synthase activity" EXACT [EC:1.2.7.2] synonym: "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)" EXACT [EC:1.2.7.2] synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2] synonym: "alpha-ketobutyrate synthase activity" EXACT [EC:1.2.7.2] synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2] xref: EC:1.2.7.2 xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN xref: UM-BBD_reactionID:r0358 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018492 name: carbon-monoxide dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2] subset: gosubset_prok synonym: "anaerobic carbon monoxide dehydrogenase activity" EXACT [EC:1.2.99.2] synonym: "carbon monoxide dehydrogenase activity" BROAD [] synonym: "carbon-monoxide:acceptor oxidoreductase activity" EXACT [EC:1.2.99.2] xref: EC:1.2.99.2 xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0415 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018493 name: formylmethanofuran dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-formylmethanofuran + A + H(2)O + H(+) = AH(2) + CO(2) + methanofuran." [EC:1.2.99.5, RHEA:19844] subset: gosubset_prok synonym: "formylmethanofuran:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.5] synonym: "formylmethanofuran:acceptor oxidoreductase activity" EXACT [EC:1.2.99.5] xref: EC:1.2.99.5 xref: KEGG:R03015 xref: MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN xref: RHEA:19844 xref: UM-BBD_reactionID:r0345 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018494 name: carvone reductase activity namespace: molecular_function def: "Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone." [UM-BBD_reactionID:r0732] xref: EC:1.3.-.- xref: MetaCyc:RXN-9403 xref: MetaCyc:RXN-9419 xref: UM-BBD_reactionID:r0732 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018495 name: 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0192] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r0192 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018496 name: 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0205] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r0205 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018497 name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [UM-BBD_reactionID:r0514] synonym: "DDMS dehydrogenase activity" EXACT [] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r0514 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018498 name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308] xref: EC:1.3.1.- xref: MetaCyc:PHENPRODIOLDEHYDROG-RXN xref: UM-BBD_enzymeID:e0308 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018499 name: cis-2,3-dihydrodiol DDT dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [UM-BBD_reactionID:r0451] xref: EC:1.3.1.- xref: UM-BBD_reactionID:r0451 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018500 name: trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [UM-BBD_reactionID:r0575] xref: EC:1.3.1.- xref: UM-BBD_reactionID:r0575 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018501 name: cis-chlorobenzene dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol." [UM-BBD_enzymeID:e0411] xref: EC:1.3.1.- xref: UM-BBD_enzymeID:e0411 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018502 name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_reactionID:r0553] xref: EC:1.3.1.- xref: MetaCyc:LINC-RXN xref: UM-BBD_reactionID:r0553 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018503 name: trans-1,2-dihydrodiolphenanthrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [UM-BBD_reactionID:r0574] xref: EC:1.3.1.- xref: UM-BBD_reactionID:r0574 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018504 name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19] subset: gosubset_prok synonym: "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.19] synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity" EXACT [EC:1.3.1.19] synonym: "cis-benzene glycol dehydrogenase activity" EXACT [EC:1.3.1.19] xref: EC:1.3.1.19 xref: MetaCyc:1.3.1.19-RXN xref: UM-BBD_enzymeID:e0060 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018505 name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29] synonym: "(+)-cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity" EXACT [] synonym: "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.29] synonym: "cis-dihydrodiol naphthalene dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] xref: EC:1.3.1.29 xref: MetaCyc:1.3.1.29-RXN xref: UM-BBD_enzymeID:e0122 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018506 name: maleylacetate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+." [EC:1.3.1.32] subset: gosubset_prok synonym: "3-oxoadipate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.32] synonym: "maleolylacetate reductase activity" EXACT [EC:1.3.1.32] xref: EC:1.3.1.32 xref: MetaCyc:MALEYLACETATE-REDUCTASE-RXN xref: UM-BBD_enzymeID:e0063 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018507 name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol." [EC:1.3.1.49, RHEA:16256] synonym: "(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity" EXACT [EC:1.3.1.49] synonym: "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity" EXACT [] xref: EC:1.3.1.49 xref: KEGG:R04151 xref: MetaCyc:1.3.1.49-RXN xref: RHEA:16256 xref: UM-BBD_reactionID:r0488 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018508 name: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "benzoate cis-diol dehydrogenase activity" EXACT [] xref: UM-BBD_enzymeID:e0219 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018509 name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56] subset: gosubset_prok synonym: "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity" EXACT [] synonym: "biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity" EXACT [EC:1.3.1.56] synonym: "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.56] xref: EC:1.3.1.56 xref: MetaCyc:1.3.1.56-RXN xref: UM-BBD_enzymeID:e0134 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018510 name: phloroglucinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrophloroglucinol + NADP(+) = H(+) + NADPH + phloroglucinol." [EC:1.3.1.57, RHEA:10083] subset: gosubset_prok synonym: "dihydrophloroglucinol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.57] xref: EC:1.3.1.57 xref: KEGG:R05308 xref: MetaCyc:R5-RXN xref: RHEA:10083 xref: UM-BBD_reactionID:r0007 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018511 name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH." [EC:1.3.1.58, RHEA:23775] subset: gosubset_prok synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.58] xref: EC:1.3.1.58 xref: KEGG:R05240 xref: MetaCyc:RXN-665 xref: RHEA:23775 xref: UM-BBD_reactionID:r0396 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018512 name: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+." [EC:1.3.1.59] comment: This term was made obsolete because, according to the Enzyme Commission, there is no evidence that this enzymatic activity exists. synonym: "1,2-dihydroxy-3-methylcyclohexa-3,5-diene-carboxylate dehydrogenase activity" EXACT [] xref: EC:1.3.1.59 xref: UM-BBD_reactionID:r0216 is_obsolete: true [Term] id: GO:0018513 name: dibenzothiophene dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH." [EC:1.3.1.60, RHEA:24191] subset: gosubset_prok synonym: "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.60] xref: EC:1.3.1.60 xref: KEGG:R05310 xref: MetaCyc:1.3.1.60-RXN xref: RHEA:24191 xref: UM-BBD_reactionID:r0161 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018515 name: pimeloyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H(+) + NADH." [EC:1.3.1.62, RHEA:19668] subset: gosubset_prok synonym: "pimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.62] xref: EC:1.3.1.62 xref: KEGG:R05311 xref: MetaCyc:1.3.1.62-RXN xref: RHEA:19668 xref: UM-BBD_reactionID:r0194 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018516 name: 2,4-dichlorobenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH." [EC:1.3.1.63, RHEA:23079] synonym: "4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)" EXACT [EC:1.3.1.63] xref: EC:1.3.1.63 xref: KEGG:R05276 xref: MetaCyc:1.3.1.63-RXN xref: RHEA:23079 xref: UM-BBD_reactionID:r0138 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018517 name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH." [EC:1.3.1.64, RHEA:13840] synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.64] xref: EC:1.3.1.64 xref: KEGG:R05275 xref: MetaCyc:1.3.1.64-RXN xref: RHEA:13840 xref: UM-BBD_reactionID:r0142 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018518 name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH." [EC:1.3.1.65, RHEA:24559] synonym: "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase" RELATED [] synonym: "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.65] xref: EC:1.3.1.65 xref: KEGG:R05312 xref: MetaCyc:RXN-643 xref: RHEA:24559 xref: UM-BBD_reactionID:r0053 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018519 name: cis-dihydroethylcatechol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH." [EC:1.3.1.66, RHEA:18104] synonym: "cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.66] synonym: "cis-ethylbenzene glycol dehydrogenase activity" EXACT [] xref: EC:1.3.1.66 xref: KEGG:R05313 xref: MetaCyc:1.3.1.66-RXN xref: RHEA:18104 xref: UM-BBD_reactionID:r0309 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018520 name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67] synonym: "4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity" EXACT [] synonym: "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.67] xref: EC:1.3.1.67 xref: MetaCyc:1.3.1.67-RXN xref: UM-BBD_reactionID:r0179 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018521 name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO(2) + NADH." [EC:1.3.1.68, RHEA:15660] synonym: "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.68] xref: EC:1.3.1.68 xref: KEGG:R05314 xref: MetaCyc:1.3.1.68-RXN xref: RHEA:15660 xref: UM-BBD_reactionID:r0224 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018522 name: benzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + donor-H2 + 2 ATP = cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate." [EC:1.3.99.15] subset: gosubset_prok synonym: "benzoyl-CoA reductase (dearomatizing) activity" EXACT [EC:1.3.99.15] synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:acceptor oxidoreductase (aromatizing, ATP-forming)" EXACT [EC:1.3.99.15] xref: EC:1.3.99.15 xref: MetaCyc:1.3.99.15-RXN xref: UM-BBD_reactionID:r0190 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0018523 name: quinoline 2-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17] subset: gosubset_prok synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.17] xref: EC:1.3.99.17 xref: MetaCyc:1.3.99.17-RXN xref: UM-BBD_reactionID:r0045 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018524 name: acetophenone carboxylase activity namespace: molecular_function alt_id: GO:0018797 def: "Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate." [UM-BBD_reactionID:r0033] xref: EC:6.4.1.- xref: UM-BBD_reactionID:r0033 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0018525 name: 4-hydroxybenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + acceptor = benzoyl-CoA + reduced acceptor." [EC:1.3.99.20] subset: gosubset_prok synonym: "4-hydroxybenzoyl-CoA reductase (dehydroxylating) activity" EXACT [EC:1.3.99.20] synonym: "4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.20] synonym: "4-hydroxybenzoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.20] xref: EC:1.3.99.20 xref: MetaCyc:1.3.99.20-RXN xref: UM-BBD_reactionID:r0158 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0018526 name: 2-aminobenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [UM-BBD_reactionID:r0342] xref: EC:1.4.-.- xref: UM-BBD_reactionID:r0342 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0018527 name: cyclohexylamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide." [EC:1.4.3.12] synonym: "cyclohexylamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.12] xref: EC:1.4.3.12 xref: MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN xref: UM-BBD_reactionID:r0754 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0018528 name: iminodiacetate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [UM-BBD_reactionID:r0589] xref: EC:1.5.-.- xref: UM-BBD_reactionID:r0589 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018529 name: nitrilotriacetate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0587] xref: EC:1.5.1.- xref: UM-BBD_reactionID:r0587 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0018530 name: (R)-6-hydroxynicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.6, RHEA:10015] subset: gosubset_prok synonym: "(R)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.6] synonym: "6-hydroxy-D-nicotine oxidase activity" EXACT [] synonym: "D-6-hydroxynicotine oxidase activity" EXACT [EC:1.5.3.6] xref: EC:1.5.3.6 xref: KEGG:R07170 xref: MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN xref: RHEA:10015 xref: UM-BBD_reactionID:r0477 is_a: GO:0019116 ! hydroxy-nicotine oxidase activity [Term] id: GO:0018531 name: (S)-6-hydroxynicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.5, RHEA:11883] subset: gosubset_prok synonym: "(S)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] synonym: "6-hydroxy-L-nicotine oxidase activity" EXACT [] synonym: "6-hydroxy-L-nicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] synonym: "L-6-hydroxynicotine oxidase activity" EXACT [] xref: EC:1.5.3.5 xref: KEGG:R03202 xref: MetaCyc:S-6-HYDROXYNICOTINE-OXIDASE-RXN xref: RHEA:11883 xref: UM-BBD_reactionID:r0478 is_a: GO:0019116 ! hydroxy-nicotine oxidase activity [Term] id: GO:0018532 name: F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_reactionID:r0353] synonym: "F420-independent methylene-H4MPT dehydrogenase activity" EXACT [] xref: EC:1.5.99.- xref: UM-BBD_reactionID:r0353 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018533 name: peptidyl-cysteine acetylation namespace: biological_process def: "The acetylation of peptidyl-cysteine." [GOC:mah] subset: gosubset_prok is_a: GO:0006473 ! protein acetylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018534 name: nitrilotriacetate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0588] xref: EC:1.5.99.- xref: UM-BBD_reactionID:r0588 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018535 name: nicotine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4] subset: gosubset_prok synonym: "D-nicotine oxidase activity" EXACT [EC:1.5.99.4] synonym: "nicotine oxidase activity" EXACT [EC:1.5.99.4] synonym: "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] synonym: "nicotine:acceptor 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] xref: EC:1.5.99.4 xref: MetaCyc:NICOTINE-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0337 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018537 name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F(420)." [EC:1.5.99.11, RHEA:21147] subset: gosubset_prok synonym: "5,10-methylenetetrahydromethanopterin cyclohydrolase activity" EXACT [EC:1.5.99.11] synonym: "5,10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] synonym: "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "methylene-H(4)MPT reductase activity" EXACT [EC:1.5.99.11] synonym: "methylene-H4MPT reductase activity" EXACT [EC:1.5.99.11] synonym: "methylenetetrahydromethanopterin reductase activity" EXACT [] synonym: "N(5),N(10)-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] synonym: "N5,N10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] xref: EC:1.5.99.11 xref: KEGG:R04464 xref: MetaCyc:METHELENE-THMPT-OXI-RXN xref: RHEA:21147 xref: UM-BBD_reactionID:r0354 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018538 name: epoxide carboxylase activity namespace: molecular_function def: "Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; an example of such a reaction is: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888] xref: EC:1.6.-.- is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0018541 name: p-benzoquinone reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)." [EC:1.6.5.6, RHEA:23491] synonym: "NADPH:p-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.6] xref: EC:1.6.5.6 xref: KEGG:R05244 xref: MetaCyc:1.6.5.6-RXN xref: RHEA:23491 xref: UM-BBD_enzymeID:e0422 is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: GO:0018542 name: 2,3-dihydroxy DDT 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_reactionID:r0452] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0452 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018543 name: 4-amino-2-nitroso-6-nitrotoluene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_reactionID:r0464] xref: EC:1.6.6.- xref: UM-BBD_reactionID:r0464 is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0018544 name: 4-carboxy-4'-sulfoazobenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_reactionID:r0543] synonym: "4-carboxy-4'-sulphoazobenzene reductase activity" EXACT [] xref: EC:1.6.6.- xref: UM-BBD_reactionID:r0543 is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0018545 name: NAD(P)H nitroreductase activity namespace: molecular_function def: "Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative." [UM-BBD_enzymeID:e0346] xref: EC:1.6.6.- xref: UM-BBD_enzymeID:e0346 is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0018546 name: nitrobenzene nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O." [MetaCyc:RXN-8815] xref: MetaCyc:RXN-8815 xref: UM-BBD_enzymeID:e0245 is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0018547 name: nitroglycerin reductase activity namespace: molecular_function def: "Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative." [UM-BBD_enzymeID:e0038] synonym: "NG reductase activity" EXACT [] xref: EC:1.7.3.- xref: UM-BBD_enzymeID:e0038 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0018548 name: pentaerythritol trinitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate." [UM-BBD_reactionID:r0025] synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028] xref: EC:1.6.99.1 xref: UM-BBD_reactionID:r0025 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0018549 name: methanethiol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide." [EC:1.8.3.4] synonym: "(MM)-oxidase activity" EXACT [EC:1.8.3.4] synonym: "methanethiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.4] synonym: "methyl mercaptan oxidase activity" EXACT [EC:1.8.3.4] synonym: "methylmercaptan oxidase activity" EXACT [EC:1.8.3.4] synonym: "MT-oxidase activity" EXACT [EC:1.8.3.4] xref: EC:1.8.3.4 xref: MetaCyc:METHANETHIOL-OXIDASE-RXN xref: UM-BBD_reactionID:r0209 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0018550 name: tetrachloro-p-hydroquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0314] synonym: "tetrachlorohydroquinone reductive dehalogenase activity" EXACT [] xref: EC:1.8.99.- xref: UM-BBD_reactionID:r0314 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0018551 name: hydrogensulfite reductase activity namespace: molecular_function def: "Catalysis of the reaction: trithionate + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor." [EC:1.8.99.3] subset: gosubset_prok synonym: "bisulfite reductase activity" EXACT [EC:1.8.99.3] synonym: "desulfofuscidin activity" NARROW [EC:1.8.99.3] synonym: "desulforubidin activity" NARROW [EC:1.8.99.3] synonym: "desulfoviridin activity" NARROW [EC:1.8.99.3] synonym: "dissimilatory sulfite reductase activity" EXACT [] synonym: "dissimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.3] synonym: "hydrogensulphite reductase activity" EXACT [] synonym: "trithionate:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.3] synonym: "trithionate:acceptor oxidoreductase activity" EXACT [EC:1.8.99.3] xref: EC:1.8.99.3 xref: MetaCyc:HYDROGENSULFITE-REDUCTASE-RXN xref: UM-BBD_reactionID:r0627 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0018553 name: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [UM-BBD_enzymeID:e0309] xref: EC:1.13.-.- xref: UM-BBD_enzymeID:e0309 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0018554 name: 1,2-dihydroxynaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:e0255] xref: EC:1.13.-.- xref: UM-BBD_enzymeID:e0255 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0018555 name: phenanthrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_reactionID:r0455] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0455 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018556 name: 2,2',3-trihydroxybiphenyl dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032] xref: EC:1.13.11.- xref: UM-BBD_enzymeID:e0032 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018557 name: 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0422] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0422 is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity [Term] id: GO:0018558 name: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_reactionID:r0049] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0049 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018559 name: 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_reactionID:r0442] synonym: "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity" EXACT [] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0442 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018560 name: protocatechuate 3,4-dioxygenase type II activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate." [UM-BBD_reactionID:r0581] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0581 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018561 name: 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_reactionID:r0457] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0457 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018562 name: 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0415] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0415 is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity [Term] id: GO:0018563 name: 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_reactionID:r0310] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0310 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018564 name: carbazole 1,9a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol." [UM-BBD_reactionID:r0456] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0456 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018565 name: dihydroxydibenzothiophene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0162] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0162 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018566 name: 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0324] synonym: "1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity" EXACT [] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0324 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018567 name: styrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_reactionID:r0256] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0256 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018568 name: 3,4-dihydroxyphenanthrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_reactionID:r0501] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0501 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018569 name: hydroquinone 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_reactionID:r0228] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0228 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018570 name: p-cumate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_reactionID:r0395] xref: EC:1.13.11.- xref: MetaCyc:RXN-664 xref: UM-BBD_reactionID:r0395 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018571 name: 2,3-dihydroxy-p-cumate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [MetaCyc:RXN-666, UM-BBD_reactionID:r0397] subset: gosubset_prok synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT [] synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT [] xref: EC:1.13.11.- xref: MetaCyc:RXN-666 xref: UM-BBD_reactionID:r0397 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018572 name: 3,5-dichlorocatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H + 2,4-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0276] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0276 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018573 name: 2-aminophenol 1,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_reactionID:r0305] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0305 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018574 name: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422] xref: EC:1.13.11.- xref: UM-BBD_enzymeID:e0422 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018575 name: chlorocatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0655] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0655 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018576 name: catechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = cis,cis-muconate." [EC:1.13.11.1] subset: gosubset_prok synonym: "1,2-pyrocatechase activity" EXACT [EC:1.13.11.1] synonym: "catechase activity" RELATED [EC:1.13.11.1] synonym: "catechol 1,2-oxygenase activity" EXACT [EC:1.13.11.1] synonym: "catechol-oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] synonym: "catechol:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] synonym: "CD I" RELATED [EC:1.13.11.1] synonym: "CD II" RELATED [EC:1.13.11.1] synonym: "pyrocatechase activity" RELATED [EC:1.13.11.1] synonym: "pyrocatechol 1,2-dioxygenase activity" EXACT [EC:1.13.11.1] xref: EC:1.13.11.1 xref: MetaCyc:CATECHOL-12-DIOXYGENASE-RXN xref: UM-BBD_enzymeID:e0064 is_a: GO:0019114 ! catechol dioxygenase activity [Term] id: GO:0018577 name: catechol 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde." [EC:1.13.11.2] subset: gosubset_prok synonym: "2,3-pyrocatechase activity" EXACT [EC:1.13.11.2] synonym: "catechol 2,3-oxygenase" EXACT [EC:1.13.11.2] synonym: "catechol oxygenase" EXACT [EC:1.13.11.2] synonym: "catechol:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.2] synonym: "cato2ase activity" RELATED [EC:1.13.11.2] synonym: "metapyrocatechase activity" RELATED [EC:1.13.11.2] synonym: "pyrocatechol 2,3-dioxygenase" EXACT [EC:1.13.11.2] xref: EC:1.13.11.2 xref: MetaCyc:CATECHOL-23-DIOXYGENASE-RXN xref: UM-BBD_enzymeID:e0156 is_a: GO:0019114 ! catechol dioxygenase activity [Term] id: GO:0018578 name: protocatechuate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3] subset: gosubset_prok synonym: "protocatechuate oxygenase activity" BROAD [EC:1.13.11.3] synonym: "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.3] synonym: "protocatechuic 3,4-dioxygenase activity" EXACT [EC:1.13.11.3] synonym: "protocatechuic 3,4-oxygenase activity" EXACT [EC:1.13.11.3] synonym: "protocatechuic acid oxidase activity" EXACT [EC:1.13.11.3] xref: EC:1.13.11.3 xref: MetaCyc:PROTOCATECHUATE-34-DIOXYGENASE-RXN xref: UM-BBD_reactionID:r0143 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018579 name: protocatechuate 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8] subset: gosubset_prok synonym: "protocatechuate 4,5-oxygenase activity" EXACT [EC:1.13.11.8] synonym: "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.8] synonym: "protocatechuic 4,5-dioxygenase activity" EXACT [EC:1.13.11.8] synonym: "protocatechuic 4,5-oxygenase activity" EXACT [EC:1.13.11.8] xref: EC:1.13.11.8 xref: MetaCyc:PROTOCATECHUATE-45-DIOXYGENASE-RXN xref: UM-BBD_reactionID:r0144 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018580 name: nitronate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ethylnitronate + FMNH(2) + O(2) = acetaldehyde + FMN + H(2)O + H(+) + nitrite." [EC:1.13.12.16, RHEA:26461] subset: gosubset_prok synonym: "2-nitropropane dioxygenase activity" RELATED [EC:1.13.11.32] synonym: "nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity" EXACT systematic_synonym [EC:1.13.12.16] xref: EC:1.13.12.16 xref: KEGG:R00025 xref: MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN xref: RHEA:26461 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0018581 name: hydroxyquinol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate." [EC:1.13.11.37] subset: gosubset_prok synonym: "benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.37] synonym: "hydroxyquinol dioxygenase activity" EXACT [EC:1.13.11.37] xref: EC:1.13.11.37 xref: MetaCyc:HYDROXYQUINOL-12-DIOXYGENASE-RXN xref: UM-BBD_reactionID:r0232 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018582 name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoate dioxygenase activity" EXACT [] synonym: "1-hydroxy-2-naphthoate-degrading enzyme activity" NARROW [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoic acid dioxygenase activity" EXACT [EC:1.13.11.38] xref: EC:1.13.11.38 xref: MetaCyc:1.13.11.38-RXN xref: UM-BBD_reactionID:r0486 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018583 name: biphenyl-2,3-diol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39] subset: gosubset_prok synonym: "2,3-dihydroxybiphenyl 1,2-dioxygenase activity" BROAD [] synonym: "2,3-dihydroxybiphenyl dioxygenase activity" BROAD [EC:1.13.11.39] synonym: "biphenyl-2,3-diol dioxygenase activity" EXACT [EC:1.13.11.39] synonym: "biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.39] xref: EC:1.13.11.39 xref: MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN xref: UM-BBD_enzymeID:e0127 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018584 name: 2,4,5-trichlorophenoxyacetic acid oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_reactionID:r0359] xref: EC:1.13.99.- xref: UM-BBD_reactionID:r0359 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0018585 name: fluorene oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [UM-BBD_reactionID:r0407] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0407 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018586 name: mono-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [UM-BBD_reactionID:r0647] synonym: "MBT dioxygenase activity" EXACT [] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0647 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018587 name: limonene 8-monooxygenase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. xref: EC:1.14.-.- xref: UM-BBD_enzymeID:e0466 is_obsolete: true replaced_by: GO:0019113 [Term] id: GO:0018588 name: tri-n-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [UM-BBD_reactionID:r0643] synonym: "TBT dioxygenase activity" EXACT [] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0643 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018589 name: di-n-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [UM-BBD_reactionID:r0645] synonym: "DBT dioxygenase activity" EXACT [] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0645 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018590 name: methylsilanetriol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [UM-BBD_reactionID:r0640] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0640 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018591 name: methyl tertiary butyl ether 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023] synonym: "MTBE 3-monooxygenase activity" EXACT [] xref: EC:1.14.-.- is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018592 name: 4-nitrocatechol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol." [UM-BBD_reactionID:r0231] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0231 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018593 name: 4-chlorophenoxyacetate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [UM-BBD_reactionID:r0281] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0281 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018594 name: tert-butyl alcohol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tert-butyl alcohol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615] xref: EC:1.14.-.- is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018595 name: alpha-pinene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_reactionID:r0716] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0716 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018596 name: dimethylsilanediol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [UM-BBD_reactionID:r0637] synonym: "DMSD hydroxylase activity" EXACT [] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0637 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018597 name: ammonia monooxygenase activity namespace: molecular_function def: "Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions." [PMID:16347810] subset: gosubset_prok xref: EC:1.14.-.- xref: UM-BBD_enzymeID:e0061 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018598 name: hydroxymethylsilanetriol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [UM-BBD_reactionID:r0641] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0641 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018599 name: 2-hydroxyisobutyrate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [UM-BBD_reactionID:r0619] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0619 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018600 name: alpha-pinene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_reactionID:r0709] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0709 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018601 name: 4-nitrophenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+)." [EC:1.14.13.29, RHEA:12571] synonym: "4-nitrophenol hydroxylase activity" EXACT [EC:1.14.13.29] synonym: "4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.29] synonym: "4-nitrophenol-2-hydroxylase activity" EXACT [EC:1.14.13.29] xref: EC:1.14.13.29 xref: KEGG:R03023 xref: MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN xref: RHEA:12571 xref: UM-BBD_reactionID:r0230 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018602 name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid = glyoxylate + 2,4-dichlorophenol." [UM-BBD_reactionID:r0274] xref: EC:1.14.11.- xref: MetaCyc:RXN-9863 xref: UM-BBD_reactionID:r0274 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0018603 name: nitrobenzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol." [UM-BBD_reactionID:r0306] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0306 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018604 name: 4-aminobenzoate 3,4-dioxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0566] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0566 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018606 name: benzenesulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_reactionID:r0295] synonym: "benzenesulphonate dioxygenase activity" EXACT [] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0295 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018607 name: 1-indanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_reactionID:r0417] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0417 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018608 name: 1-indanone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_reactionID:r0416] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0416 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018609 name: chlorobenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062] xref: EC:1.14.12.- xref: UM-BBD_enzymeID:e0062 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018610 name: dibenzofuran 4,4a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN] xref: EC:1.14.12.- xref: MetaCyc:R606-RXN xref: UM-BBD_enzymeID:e0030 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018611 name: toluate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190] xref: EC:1.14.12.- xref: UM-BBD_enzymeID:e0190 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018612 name: dibenzothiophene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_reactionID:r0160] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0160 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018613 name: 9-fluorenone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_reactionID:r0409] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0409 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018614 name: ethylbenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_reactionID:r0247] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0247 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018615 name: 2-indanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_reactionID:r0424] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0424 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018616 name: trihydroxytoluene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [MetaCyc:R305-RXN, UM-BBD_reactionID:r0093] xref: EC:1.14.12.- xref: MetaCyc:R305-RXN xref: UM-BBD_reactionID:r0093 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018617 name: 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_reactionID:r0580] synonym: "4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity" EXACT [] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0580 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018618 name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1] subset: gosubset_prok synonym: "AntA" RELATED [] synonym: "AntB" RELATED [] synonym: "AntC" RELATED [] synonym: "anthranilate 1,2-dioxygenase" RELATED [] synonym: "anthranilate dioxygenase activity" EXACT [] synonym: "anthranilate dioxygenase reductase" NARROW [] synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.12.1] synonym: "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)" EXACT [EC:1.14.12.1] synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.12.1] synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.12.1] xref: EC:1.14.12.1 xref: MetaCyc:1.14.12.1-RXN xref: UM-BBD_reactionID:r0577 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018619 name: benzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzene + H(+) + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.3, RHEA:13816] subset: gosubset_prok synonym: "benzene dioxygenase activity" EXACT [EC:1.14.12.3] synonym: "benzene hydroxylase activity" RELATED [EC:1.14.12.3] synonym: "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.3] xref: EC:1.14.12.3 xref: KEGG:R03543 xref: MetaCyc:BENZENE-12-DIOXYGENASE-RXN xref: RHEA:13816 xref: UM-BBD_reactionID:r0079 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018620 name: phthalate 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)." [EC:1.14.12.7, RHEA:17492] subset: gosubset_prok synonym: "PDO activity" EXACT [EC:1.14.12.7] synonym: "phthalate dioxygenase activity" BROAD [EC:1.14.12.7] synonym: "phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)" EXACT [EC:1.14.12.7] xref: EC:1.14.12.7 xref: KEGG:R03630 xref: MetaCyc:PHTHALATE-45-DIOXYGENASE-RXN xref: RHEA:17492 xref: UM-BBD_reactionID:r0102 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018621 name: 4-sulfobenzoate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfobenzoate + H(+) + NADH + O(2) = 3,4-dihydroxybenzoate + NAD(+) + sulfite." [EC:1.14.12.8, RHEA:13940] synonym: "4-sulfobenzoate 3,4-dioxygenase system" RELATED [EC:1.14.12.8] synonym: "4-sulfobenzoate dioxygenase activity" EXACT [EC:1.14.12.8] synonym: "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)" EXACT [EC:1.14.12.8] synonym: "4-sulphobenzoate 3,4-dioxygenase activity" EXACT [] xref: EC:1.14.12.8 xref: KEGG:R01636 xref: MetaCyc:4-SULFOBENZOATE-34-DIOXYGENASE-RXN xref: RHEA:13940 xref: UM-BBD_reactionID:r0293 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018622 name: 4-chlorophenylacetate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorophenylacetate + NADH + O(2) = 3,4-dihydroxyphenylacetate + chloride + NAD(+)." [EC:1.14.12.9, RHEA:14692] synonym: "4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)" EXACT [EC:1.14.12.9] xref: EC:1.14.12.9 xref: KEGG:R03306 xref: MetaCyc:1.14.12.9-RXN xref: RHEA:14692 xref: UM-BBD_reactionID:r0308 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018623 name: benzoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+." [EC:1.14.12.10] subset: gosubset_prok synonym: "benzoate dioxygenase activity" EXACT [EC:1.14.12.10] synonym: "benzoate hydroxylase activity" EXACT [EC:1.14.12.10] synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.10] synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)" EXACT [EC:1.14.12.10] synonym: "benzoic hydroxylase activity" EXACT [EC:1.14.12.10] xref: EC:1.14.12.10 xref: MetaCyc:BENZOATE-12-DIOXYGENASE-RXN xref: UM-BBD_enzymeID:e0154 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018624 name: toluene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.11, RHEA:16740] synonym: "toluene 1,2-dioxygenase activity" EXACT [EC:1.14.12.11] synonym: "toluene 2,3-dioxygenase activity" EXACT [EC:1.14.12.11] synonym: "toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.11] xref: EC:1.14.12.11 xref: KEGG:R03559 xref: MetaCyc:TOLUENE-DIOXYGENASE-RXN xref: RHEA:16740 xref: UM-BBD_enzymeID:e0155 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018625 name: naphthalene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12] subset: gosubset_prok synonym: "naphthalene dioxygenase activity" EXACT [EC:1.14.12.12] synonym: "naphthalene oxygenase activity" EXACT [EC:1.14.12.12] synonym: "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.12] xref: EC:1.14.12.12 xref: MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN xref: UM-BBD_enzymeID:e0002 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018626 name: 2-chlorobenzoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13] subset: gosubset_prok synonym: "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)" EXACT [EC:1.14.12.13] synonym: "2-halobenzoate 1,2-dioxygenase activity" EXACT [] xref: EC:1.14.12.13 xref: MetaCyc:2-CHLOROBENZOATE-12-DIOXYGENASE-RXN xref: UM-BBD_reactionID:r0632 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018627 name: 2-aminobenzenesulfonate 2,3-dioxygenase activity namespace: molecular_function alt_id: GO:0018605 def: "Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol." [EC:1.14.12.14, RHEA:23471] synonym: "2-aminobenzenesulfonate dioxygenase activity" EXACT [] synonym: "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)" EXACT [EC:1.14.12.14] synonym: "2-aminobenzenesulphonate 2,3-dioxygenase activity" EXACT [] synonym: "2-aminobenzenesulphonate dioxygenase activity" EXACT [] synonym: "2-aminosulfobenzene 2,3-dioxygenase activity" EXACT [EC:1.14.12.14] xref: EC:1.14.12.14 xref: KEGG:R05156 xref: MetaCyc:2ASDOSALCAL-RXN xref: RHEA:23471 xref: UM-BBD_reactionID:r0218 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018628 name: terephthalate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)." [EC:1.14.12.15, RHEA:10315] synonym: "1,4-dicarboxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] synonym: "benzene-1,4-dicarboxylate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] synonym: "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.15] xref: EC:1.14.12.15 xref: KEGG:R05148 xref: MetaCyc:1.14.12.15-RXN xref: RHEA:10315 xref: UM-BBD_reactionID:r0150 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018629 name: 2-hydroxyquinoline 5,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16] synonym: "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity" EXACT [] synonym: "quinolin-2(1H)-one 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] synonym: "quinolin-2-ol 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] synonym: "quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)" EXACT [EC:1.14.12.16] xref: EC:1.14.12.16 xref: MetaCyc:1.14.12.16-RXN xref: UM-BBD_reactionID:r0052 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018630 name: 3,5-xylenol methylhydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_reactionID:r0081] xref: EC:1.14.13.- xref: MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN xref: UM-BBD_reactionID:r0081 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018631 name: phenylacetate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate." [UM-BBD_reactionID:r0036] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0036 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018632 name: 4-nitrophenol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone." [UM-BBD_reactionID:r0226] xref: EC:1.14.13.- xref: MetaCyc:RXN-8739 xref: UM-BBD_reactionID:r0226 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018633 name: dimethyl sulfide monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde." [UM-BBD_reactionID:r0208] synonym: "dimethyl sulphide monooxygenase activity" EXACT [] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0208 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018634 name: alpha-pinene monooxygenase [NADH] activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [UM-BBD_reactionID:r0742] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0742 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018635 name: (R)-limonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-(4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide." [UM-BBD_enzymeID:e0462] synonym: "(+)-limonene 1,2-monooxygenase activity" EXACT [EC:1.14.13.107] synonym: "(+)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] synonym: "(R)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] xref: EC:1.14.13.107 xref: MetaCyc:RXN-9407 xref: UM-BBD_reactionID:r0733 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018636 name: phenanthrene 9,10-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [UM-BBD_reactionID:r0495] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0495 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018637 name: 1-hydroxy-2-naphthoate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [UM-BBD_reactionID:r0491] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0491 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018638 name: toluene 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene." [UM-BBD_enzymeID:e0225] xref: EC:1.14.13.- xref: UM-BBD_enzymeID:e0225 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018639 name: xylene monooxygenase activity namespace: molecular_function def: "Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172] xref: EC:1.14.13.- xref: UM-BBD_enzymeID:e0172 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018640 name: dibenzothiophene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621] xref: EC:1.14.13.- xref: MetaCyc:RXN-621 xref: UM-BBD_enzymeID:e0214 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018641 name: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [UM-BBD_reactionID:r0048] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0048 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018642 name: chlorophenol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252] xref: EC:1.14.13.- xref: UM-BBD_enzymeID:e0252 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018643 name: carbon disulfide oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_reactionID:r0599] synonym: "carbon disulphide oxygenase activity" EXACT [] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0599 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018644 name: toluene 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [UM-BBD_enzymeID:e0222] xref: EC:1.14.13.- xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0222 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018645 name: alkene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69] synonym: "alkene epoxygenase activity" EXACT [EC:1.14.13.69] synonym: "alkene,NADH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.69] xref: EC:1.14.13.69 xref: MetaCyc:1.14.13.69-RXN xref: UM-BBD_enzymeID:e0039 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018646 name: 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_reactionID:r0736] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0736 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018647 name: phenanthrene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [UM-BBD_enzymeID:e0333] xref: EC:1.14.13.- xref: UM-BBD_enzymeID:e0333 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018648 name: methanesulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O." [EC:1.14.13.111] synonym: "mesylate monooxygenase activity" EXACT [EC:1.14.13.111] synonym: "methanesulfonate,FMNH2:oxygen oxidoreductase activity" EXACT [EC:1.14.13.111] synonym: "methanesulfonate,NADH:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.111] synonym: "methanesulfonic acid monooxygenase activity" EXACT [EC:1.14.13.111] synonym: "methanesulphonic acid monooxygenase activity" EXACT [GOC:mah] synonym: "MSA monooxygenase activity" EXACT [EC:1.14.13.111] synonym: "MSAMO activity" EXACT [EC:1.14.13.111] xref: EC:1.14.13.111 xref: MetaCyc:RXN-9770 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018649 name: tetrahydrofuran hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_reactionID:r0017] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0017 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018650 name: styrene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_reactionID:r0225] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0225 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018651 name: toluene-4-sulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_reactionID:r0296] synonym: "toluene-4-sulphonate monooxygenase activity" EXACT [] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0296 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018652 name: toluene-sulfonate methyl-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [UM-BBD_reactionID:r0290] synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT [] xref: EC:1.14.13.- xref: MetaCyc:TSMOS-RXN xref: UM-BBD_reactionID:r0290 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018653 name: 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [EC:1.14.13.-] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0046 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018654 name: 2-hydroxy-phenylacetate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [UM-BBD_reactionID:r0252] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0252 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018655 name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_reactionID:r0430] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0430 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018656 name: phenanthrene 3,4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [UM-BBD_reactionID:r0508] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0508 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018657 name: toluene 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene." [UM-BBD_enzymeID:e0224] xref: EC:1.14.13.- xref: MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0224 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018658 name: salicylate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1] subset: gosubset_prok synonym: "salicylate 1-hydroxylase activity" EXACT [EC:1.14.13.1] synonym: "salicylate hydroxylase (decarboxylating)" EXACT [EC:1.14.13.1] synonym: "salicylate hydroxylase activity" EXACT [] synonym: "salicylate monooxygenase activity" EXACT [EC:1.14.13.1] synonym: "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.1] synonym: "salicylic hydroxylase activity" EXACT [EC:1.14.13.1] xref: EC:1.14.13.1 xref: MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0149 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018659 name: 4-hydroxybenzoate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2] subset: gosubset_prok synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "4-hydroxybenzoate monooxygenase activity" EXACT [EC:1.14.13.2] synonym: "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoate hydrolyase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "p-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoic acid hydrolase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoic acid hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "p-hydroxybenzoic hydroxylase activity" EXACT [EC:1.14.13.2] synonym: "para-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] xref: EC:1.14.13.2 xref: MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN xref: UM-BBD_reactionID:r0109 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018660 name: 4-hydroxyphenylacetate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [EC:1.14.13.3] subset: gosubset_prok synonym: "4 HPA 3-hydroxylase activity" EXACT [EC:1.14.13.3] synonym: "4-hydroxyphenylacetate 3-hydroxylase activity" EXACT [] synonym: "4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.3] synonym: "4-hydroxyphenylacetic acid-3-hydroxylase activity" EXACT [EC:1.14.13.3] synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" EXACT [EC:1.14.13.3] synonym: "p-hydroxyphenylacetate hydroxylase activity" EXACT [EC:1.14.13.3] xref: EC:1.14.13.3 xref: MetaCyc:1.14.13.3-RXN xref: UM-BBD_reactionID:r0301 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018661 name: orcinol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + orcinol = 2,3,5-trihydroxytoluene + H(2)O + NAD(+)." [EC:1.14.13.6, RHEA:19604] synonym: "orcinol hydroxylase activity" EXACT [] synonym: "orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.6] xref: EC:1.14.13.6 xref: KEGG:R02830 xref: MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN xref: RHEA:19604 xref: UM-BBD_reactionID:r0092 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018662 name: phenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O." [EC:1.14.13.7] subset: gosubset_prok synonym: "phenol hydroxylase activity" EXACT [EC:1.14.13.7] synonym: "phenol o-hydroxylase activity" EXACT [EC:1.14.13.7] synonym: "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.7] xref: EC:1.14.13.7 xref: MetaCyc:PHENOL-2-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0208 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018663 name: 2,6-dihydroxypyridine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+)." [EC:1.14.13.10, RHEA:16920] synonym: "2,6-dihydroxypyridine oxidase activity" EXACT [] synonym: "2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.10] xref: EC:1.14.13.10 xref: KEGG:R04130 xref: MetaCyc:1.14.13.10-RXN xref: RHEA:16920 xref: UM-BBD_reactionID:r0479 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018664 name: benzoate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + H(+) + NADPH + O(2) = 4-hydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.12, RHEA:18036] synonym: "4-hydroxybenzoic hydroxylase activity" EXACT [] synonym: "benzoate 4-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.12] synonym: "benzoate-p-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoate-para-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoic 4-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoic acid 4-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "p-hydroxybenzoate hydroxylase activity" EXACT [EC:1.14.13.12] xref: EC:1.14.13.12 xref: KEGG:R01295 xref: MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN xref: RHEA:18036 xref: UM-BBD_reactionID:r0623 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018665 name: 4-hydroxyphenylacetate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18] synonym: "4-HPA 1-hydroxylase activity" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenyl-acetate 1-hydroxylase activity" EXACT [] synonym: "4-hydroxyphenylacetate 1-hydroxylase activity" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenylacetic 1-hydroxylase activity" EXACT [EC:1.14.13.18] xref: EC:1.14.13.18 xref: MetaCyc:1.14.13.18-RXN xref: UM-BBD_reactionID:r0300 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018666 name: 2,4-dichlorophenol 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20] subset: gosubset_prok synonym: "2,4-dichlorophenol hydroxylase activity" EXACT [] synonym: "2,4-dichlorophenol monooxygenase activity" EXACT [EC:1.14.13.20] synonym: "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.20] xref: EC:1.14.13.20 xref: MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0152 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018667 name: cyclohexanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22] subset: gosubset_prok synonym: "cyclohexanone 1,2-monooxygenase activity" EXACT [] synonym: "cyclohexanone oxygenase activity" EXACT [EC:1.14.13.22] synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity" EXACT [EC:1.14.13.22] synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)" EXACT [EC:1.14.13.22] xref: EC:1.14.13.22 xref: MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN xref: UM-BBD_reactionID:r0166 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018668 name: 3-hydroxybenzoate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.23, RHEA:11483] synonym: "3-hydroxybenzoate 4-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.23] xref: EC:1.14.13.23 xref: KEGG:R01628 xref: MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN xref: RHEA:11483 xref: UM-BBD_reactionID:r0153 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018669 name: 3-hydroxybenzoate 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADH + O(2) = 2,5-dihydroxybenzoate + H(2)O + NAD(+)." [EC:1.14.13.24, RHEA:22695] synonym: "3-hydroxybenzoate 6-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.24] synonym: "3-hydroxybenzoic acid-6-hydroxylase activity" EXACT [EC:1.14.13.24] synonym: "m-hydroxybenzoate 6-hydroxylase activity" EXACT [EC:1.14.13.24] xref: EC:1.14.13.24 xref: KEGG:R02589 xref: MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN xref: RHEA:22695 xref: UM-BBD_reactionID:r0402 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018670 name: 4-aminobenzoate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27] synonym: "4-aminobenzoate dehydrogenase activity" EXACT [EC:1.14.13.27] synonym: "4-aminobenzoate hydroxylase activity" EXACT [] synonym: "4-aminobenzoate monooxygenase activity" EXACT [EC:1.14.13.27] synonym: "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.27] xref: EC:1.14.13.27 xref: MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN xref: UM-BBD_reactionID:r0597 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018671 name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33] synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.33] synonym: "4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))" EXACT [] synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.33] synonym: "4-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.33] xref: EC:1.14.13.33 xref: MetaCyc:1.14.13.33-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018672 name: anthranilate 3-monooxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + 2 H(+) + NADPH + O(2) = 2,3-dihydroxybenzoate + NADP(+) + NH(4)(+)." [EC:1.14.13.35, RHEA:21239] synonym: "anthranilate 2,3-dioxygenase (deaminating)" EXACT [EC:1.14.13.35] synonym: "anthranilate 2,3-hydroxylase (deaminating) activity" EXACT [EC:1.14.13.35] synonym: "anthranilate hydroxylase (deaminating) activity" EXACT [] synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.13.35] synonym: "anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)" EXACT [EC:1.14.13.35] xref: EC:1.14.13.35 xref: KEGG:R00980 xref: MetaCyc:1.14.13.35-RXN xref: RHEA:21239 xref: UM-BBD_reactionID:r0578 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018673 name: anthraniloyl-CoA monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40] subset: gosubset_prok synonym: "2-aminobenzoyl-CoA monooxygenase/reductase activity" EXACT [EC:1.14.13.40] synonym: "2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)" EXACT [EC:1.14.13.40] synonym: "anthraniloyl coenzyme A reductase activity" EXACT [EC:1.14.13.40] xref: EC:1.14.13.40 xref: MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN xref: UM-BBD_reactionID:r0568 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018674 name: (S)-limonene 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (1S,6R)-isopiperitenol + H(2)O + NADP(+)." [EC:1.14.13.47, RHEA:15132] synonym: "(-)-limonene 3-hydroxylase activity" EXACT [EC:1.14.13.47] synonym: "(-)-limonene 3-monooxygenase activity" EXACT [] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.13.47] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.47] synonym: "limonene 3-hydroxylase activity" EXACT [] xref: EC:1.14.13.47 xref: KEGG:R02469 xref: MetaCyc:--LIMONENE-3-MONOOXYGENASE-RXN xref: RHEA:15132 xref: UM-BBD_reactionID:r0739 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018675 name: (S)-limonene 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O." [EC:1.14.13.48] synonym: "(-)-limonene 6-hydroxylase activity" EXACT [EC:1.14.13.48] synonym: "(-)-limonene 6-monooxygenase activity" EXACT [] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.48] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.48] synonym: "limonene 6-hydroxylase activity" EXACT [] xref: EC:1.14.13.48 xref: MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN xref: UM-BBD_reactionID:r0713 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018676 name: (S)-limonene 7-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+)." [EC:1.14.13.49, RHEA:23435] synonym: "(-)-limonene 7-monooxygenase activity" EXACT [] synonym: "(-)-limonene hydroxylase activity" EXACT [EC:1.14.13.49] synonym: "(-)-limonene monooxygenase activity" EXACT [EC:1.14.13.49] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating) activity" EXACT [EC:1.14.13.49] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.13.49] synonym: "limonene hydroxylase activity" EXACT [] xref: EC:1.14.13.49 xref: KEGG:R02470 xref: MetaCyc:--LIMONENE-7-MONOOXYGENASE-RXN xref: RHEA:23435 xref: UM-BBD_reactionID:r0728 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018677 name: pentachlorophenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50] subset: gosubset_prok synonym: "PCB 4-monooxygenase activity" EXACT [EC:1.14.13.50] synonym: "PCB4MO activity" EXACT [EC:1.14.13.50] synonym: "PCP hydroxylase activity" EXACT [EC:1.14.13.50] synonym: "PcpB" RELATED [EC:1.14.13.50] synonym: "pentachlorophenol 4-monooxygenase activity" EXACT [] synonym: "pentachlorophenol dechlorinase activity" EXACT [EC:1.14.13.50] synonym: "pentachlorophenol dehalogenase activity" EXACT [EC:1.14.13.50] synonym: "pentachlorophenol hydroxylase activity" EXACT [] synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" EXACT [EC:1.14.13.50] xref: EC:1.14.13.50 xref: MetaCyc:PCP4MONO-RXN xref: UM-BBD_enzymeID:e0148 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018678 name: 4-hydroxybenzoate 1-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64] synonym: "4-hydroxybenzoate 1-monooxygenase activity" EXACT [] synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.64] xref: EC:1.14.13.64 xref: MetaCyc:1.14.13.64-RXN xref: UM-BBD_reactionID:r0752 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018679 name: dibenzothiophene-5,5-dioxide monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate." [UM-BBD_reactionID:r0235] xref: EC:1.14.14.- xref: MetaCyc:RXN-623 xref: UM-BBD_reactionID:r0235 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018680 name: deethylatrazine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_reactionID:r0128] xref: EC:1.14.15.- xref: UM-BBD_reactionID:r0128 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018681 name: deisopropylatrazine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine." [KEGG:R05567] xref: EC:1.14.15.- xref: KEGG:R05567 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018682 name: atrazine N-dealkylase activity namespace: molecular_function def: "Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O." [MetaCyc:R461-RXN, UM-BBD_reactionID:r0127] synonym: "atrazine monooxygenase activity" RELATED [UM-BBD_enzymeID:e0090] xref: EC:1.14.15.- xref: MetaCyc:R461-RXN xref: UM-BBD_reactionID:r0127 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018683 name: camphor 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1] subset: gosubset_prok synonym: "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.15.1] synonym: "2-bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor 5-exo-methylene hydroxylase activity" EXACT [] synonym: "camphor 5-exohydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor methylene hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "cytochrome p450-cam activity" EXACT [EC:1.14.15.1] synonym: "d-camphor monooxygenase activity" EXACT [EC:1.14.15.1] synonym: "D-camphor-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "methylene hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "methylene monooxygenase activity" EXACT [EC:1.14.15.1] xref: EC:1.14.15.1 xref: MetaCyc:R541-RXN xref: UM-BBD_enzymeID:e0300 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018684 name: camphor 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-bornane-2,5-dione + reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + H2O." [EC:1.14.15.2] synonym: "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.15.2] synonym: "2,5-diketocamphane lactonizing enzyme activity" EXACT [EC:1.14.15.2] synonym: "camphor ketolactonase I activity" EXACT [EC:1.14.15.2] synonym: "ketolactonase I" RELATED [EC:1.14.15.2] synonym: "oxygenase, camphor 1,2-mono" EXACT [EC:1.14.15.2] xref: EC:1.14.15.2 xref: MetaCyc:CAMPHOR-12-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0302 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018685 name: alkane 1-monooxygenase activity namespace: molecular_function alt_id: GO:0008393 def: "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] subset: gosubset_prok synonym: "1-hydroxylase activity" EXACT [EC:1.14.15.3] synonym: "alkane 1-hydroxylase activity" EXACT [] synonym: "alkane hydroxylase activity" EXACT [EC:1.14.15.3] synonym: "alkane monooxygenase activity" EXACT [EC:1.14.15.3] synonym: "alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity" EXACT [EC:1.14.15.3] synonym: "fatty acid (omega-1)-hydroxylase activity" EXACT [] synonym: "fatty acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3] xref: EC:1.14.15.3 xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0022 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018686 name: 6-hydroxy pseudo-oxynicotine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [UM-BBD_reactionID:r0480] xref: EC:1.14.18.- xref: UM-BBD_reactionID:r0480 is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018687 name: biphenyl 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD. This reaction requires Fe2+." [EC:1.14.12.18] subset: gosubset_prok synonym: "biphenyl dioxygenase activity" EXACT [EC:1.14.12.18] synonym: "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)" EXACT [EC:1.14.12.18] xref: EC:1.14.12.18 xref: MetaCyc:1.14.12.18-RXN xref: UM-BBD_enzymeID:e0089 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018688 name: DDT 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [UM-BBD_reactionID:r0450] xref: EC:1.14.99.- xref: UM-BBD_reactionID:r0450 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0018689 name: naphthalene disulfonate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [UM-BBD_enzymeID:e0249] synonym: "naphthalene disulphonate 1,2-dioxygenase activity" EXACT [] xref: EC:1.14.99.- xref: UM-BBD_enzymeID:e0249 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018690 name: 4-methoxybenzoate monooxygenase (O-demethylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O." [EC:1.14.99.15, RHEA:18616] synonym: "4-methoxybenzoate 4-monooxygenase (O-demethylating)" EXACT [EC:1.14.99.15] synonym: "4-methoxybenzoate monooxygenase activity" EXACT [] synonym: "4-methoxybenzoate O-demethylase activity" EXACT [EC:1.14.99.15] synonym: "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)" EXACT [EC:1.14.99.15] synonym: "p-anisic O-demethylase activity" EXACT [EC:1.14.99.15] synonym: "piperonylate-4-O-demethylase activity" EXACT [EC:1.14.99.15] xref: EC:1.14.99.15 xref: KEGG:R01306 xref: MetaCyc:1.14.99.15-RXN xref: RHEA:18616 xref: UM-BBD_reactionID:r0154 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018693 name: ethylbenzene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2)." [EC:1.17.99.2, RHEA:17900] synonym: "ethylbenzene dehydrogenase activity" EXACT [EC:1.17.99.2] synonym: "ethylbenzene:(acceptor) oxidoreductase activity" EXACT [EC:1.17.99.2] xref: EC:1.17.99.2 xref: KEGG:R05745 xref: MetaCyc:RXN-1301 xref: RHEA:17900 xref: UM-BBD_reactionID:r0234 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0018694 name: p-cymene methyl hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_reactionID:r0392] xref: EC:1.17.99.- xref: MetaCyc:RXN-661 xref: UM-BBD_reactionID:r0392 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0018695 name: 4-cresol dehydrogenase (hydroxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.99.1] subset: gosubset_prok synonym: "4-cresol dehydrogenase activity" EXACT [] synonym: "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)" EXACT [EC:1.17.99.1] synonym: "p-cresol methylhydroxylase activity" EXACT [EC:1.17.99.1] synonym: "p-cresol-(acceptor) oxidoreductase (hydroxylating) activity" EXACT [EC:1.17.99.1] xref: EC:1.17.99.1 xref: MetaCyc:1.17.99.1-RXN xref: UM-BBD_reactionID:r0272 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0018697 name: carbonyl sulfide nitrogenase activity namespace: molecular_function def: "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide." [UM-BBD_reactionID:r0600] synonym: "carbonyl sulphide nitrogenase activity" EXACT [] xref: EC:1.18.6.1 xref: UM-BBD_reactionID:r0600 is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor [Term] id: GO:0018698 name: vinyl chloride reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene." [UM-BBD_reactionID:r0352] xref: EC:1.97.1.- xref: MetaCyc:VCREDCHLOR-RXN xref: UM-BBD_reactionID:r0352 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018699 name: 1,1,1-trichloroethane reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl." [UM-BBD_reactionID:r1007] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r1007 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018700 name: 2-chloro-N-isopropylacetanilide reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_reactionID:r0719] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0719 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018701 name: 2,5-dichlorohydroquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366] xref: EC:1.97.1.- xref: UM-BBD_enzymeID:e0366 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018702 name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0440] synonym: "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity" EXACT [] synonym: "DDE dehalogenase activity" EXACT [] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0440 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018703 name: 2,4-dichlorophenoxyacetate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [UM-BBD_reactionID:r0280] xref: UM-BBD_reactionID:r0280 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018704 name: 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0237] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. xref: EC:1.97.1.- xref: UM-BBD_enzymeID:e0237 is_obsolete: true [Term] id: GO:0018705 name: 1,2-dichloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [UM-BBD_enzymeID:e0272] synonym: "1,2-dichloroethylene reductive dehalogenase activity" EXACT [] xref: UM-BBD_enzymeID:e0272 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018706 name: pyrogallol hydroxytransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [EC:1.97.1.2] subset: gosubset_prok synonym: "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity" EXACT [EC:1.97.1.2] synonym: "pyrogallol hydroxyltransferase activity" EXACT [] synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2] xref: EC:1.97.1.2 xref: MetaCyc:1.97.1.2-RXN xref: UM-BBD_reactionID:r0006 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018707 name: 1-phenanthrol methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [UM-BBD_reactionID:r0493] xref: EC:2.1.1.- xref: UM-BBD_reactionID:r0493 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0018708 name: thiol S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9] synonym: "S-adenosyl-L-methionine:thiol S-methyltransferase activity" EXACT [EC:2.1.1.9] synonym: "thiol methyltransferase activity" EXACT [EC:2.1.1.9] synonym: "TMT" RELATED [EC:2.1.1.9] xref: EC:2.1.1.9 xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN xref: Reactome:9948 "thiol S-methyltransferase activity" xref: UM-BBD_enzymeID:e0146 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018710 name: acetone carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: acetone + ATP + CO(2) + 2 H(2)O = acetoacetate + AMP + 4 H(+) + 2 phosphate." [EC:6.4.1.6, RHEA:18388] synonym: "acetone:carbon-dioxide ligase (AMP-forming)" EXACT [EC:6.4.1.6] xref: EC:6.4.1.6 xref: KEGG:R05735 xref: MetaCyc:6.4.1.6-RXN xref: RHEA:18388 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0018711 name: benzoyl acetate-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_reactionID:r0243] xref: EC:2.3.1.- xref: MetaCyc:RXN-1305 xref: UM-BBD_reactionID:r0243 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0018712 name: 3-hydroxybutyryl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0010] xref: EC:2.3.1.- xref: MetaCyc:R7-RXN xref: UM-BBD_reactionID:r0010 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0018713 name: 3-ketopimelyl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0197] xref: EC:2.3.1.- xref: MetaCyc:RXN-8032 xref: UM-BBD_reactionID:r0197 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0018715 name: 9-phenanthrol UDP-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [UM-BBD_reactionID:r0567] xref: EC:2.4.1.- xref: UM-BBD_reactionID:r0567 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0018716 name: 1-phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0525] xref: EC:2.4.1.- xref: UM-BBD_reactionID:r0525 is_a: GO:0019112 ! phenanthrol glycosyltransferase activity [Term] id: GO:0018717 name: 9-phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0511] xref: EC:2.4.1.- xref: UM-BBD_reactionID:r0511 is_a: GO:0019112 ! phenanthrol glycosyltransferase activity [Term] id: GO:0018718 name: 1,2-dihydroxy-phenanthrene glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [UM-BBD_reactionID:r0569] xref: EC:2.4.1.- xref: UM-BBD_reactionID:r0569 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0018719 name: 6-aminohexanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_reactionID:r0449] xref: EC:2.6.1.- xref: MetaCyc:R562-RXN xref: UM-BBD_reactionID:r0449 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0018720 name: phenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate." [UM-BBD_reactionID:r0155] xref: EC:2.7.1.- xref: MetaCyc:PHENOLPHOS-RXN xref: UM-BBD_reactionID:r0155 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0018721 name: trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0559] synonym: "trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: UM-BBD_reactionID:r0559 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0018722 name: 1-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [UM-BBD_reactionID:r0565] synonym: "1-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: UM-BBD_reactionID:r0565 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018723 name: 3-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [UM-BBD_reactionID:r0561] synonym: "3-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: UM-BBD_reactionID:r0561 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018724 name: 4-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [UM-BBD_reactionID:r0562] synonym: "4-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: UM-BBD_reactionID:r0562 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018725 name: trans-3,4-dihydrodiolphenanthrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0558] synonym: "trans-3,4-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: UM-BBD_reactionID:r0558 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0018726 name: 9-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [UM-BBD_reactionID:r0564] synonym: "9-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: UM-BBD_reactionID:r0564 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018727 name: 2-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [UM-BBD_reactionID:r0563] synonym: "2-phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: UM-BBD_reactionID:r0563 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018729 name: propionate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA." [EC:2.8.3.1] subset: gosubset_prok synonym: "acetyl-CoA:propanoate CoA-transferase activity" EXACT [EC:2.8.3.1] synonym: "propionate coenzyme A-transferase activity" EXACT [EC:2.8.3.1] synonym: "propionate-CoA:lactoyl-CoA transferase activity" EXACT [EC:2.8.3.1] synonym: "propionyl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.1] synonym: "propionyl-CoA transferase activity" EXACT [EC:2.8.3.1] xref: EC:2.8.3.1 xref: MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN xref: UM-BBD_reactionID:r0087 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0018730 name: glutaconate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12] subset: gosubset_prok synonym: "acetyl-CoA:(E)-glutaconate CoA-transferase activity" EXACT [EC:2.8.3.12] xref: EC:2.8.3.12 xref: MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN xref: UM-BBD_reactionID:r0085 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0018731 name: 1-oxa-2-oxocycloheptane lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [UM-BBD_reactionID:r0167] xref: EC:3.1.1.- xref: UM-BBD_reactionID:r0167 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018732 name: sulfolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [UM-BBD_reactionID:r0583] synonym: "sulpholactone hydrolase activity" EXACT [] xref: EC:3.1.1.- xref: UM-BBD_reactionID:r0583 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018733 name: 3,4-dihydrocoumarin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [UM-BBD_reactionID:r0419] xref: EC:3.1.1.- xref: UM-BBD_reactionID:r0419 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018734 name: butyrolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate." [UM-BBD_reactionID:r0016] xref: EC:3.1.1.- xref: UM-BBD_reactionID:r0016 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018736 name: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [UM-BBD_reactionID:r0206] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r0206 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018737 name: 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [UM-BBD_reactionID:r0193] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r0193 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018738 name: S-formylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14964] subset: gosubset_prok xref: EC:3.1.2.12 xref: KEGG:R00527 xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN xref: RHEA:14964 xref: UM-BBD_reactionID:r0241 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0018739 name: 4-hydroxybenzoyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA + H(+)." [EC:3.1.2.23, RHEA:11951] subset: gosubset_prok synonym: "4-hydroxybenzoyl-CoA hydrolase activity" EXACT [EC:3.1.2.23] synonym: "4-hydroxybenzoyl-CoA thiolesterase activity" EXACT [] xref: EC:3.1.2.23 xref: KEGG:R01301 xref: MetaCyc:3.1.2.23-RXN xref: RHEA:11951 xref: UM-BBD_reactionID:r0141 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0018740 name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H(2)O = biphenyl-2-ol + sulfite." [EC:3.13.1.3, RHEA:12948] subset: gosubset_prok synonym: "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity" EXACT [] synonym: "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity" EXACT [] synonym: "dibenzothiophene desulfurization enzyme B" RELATED [EC:3.13.1.3] synonym: "DszB" RELATED [EC:3.13.1.3] synonym: "gene dszB-encoded hydrolase activity" EXACT [EC:3.13.1.3] synonym: "HBPSi desulfinase activity" EXACT [EC:3.13.1.3] synonym: "HPBS desulfinase activity" EXACT [EC:3.13.1.3] xref: EC:3.13.1.3 xref: KEGG:R07311 xref: MetaCyc:RXN-624 xref: RHEA:12948 xref: UM-BBD_enzymeID:e0216 is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds [Term] id: GO:0018741 name: alkyl sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: dodecyl sulfate + H2O = sulfate + H+ + 1-dodecanol." [UM-BBD_reactionID:r0602] synonym: "alkyl sulphatase activity" EXACT [] xref: EC:3.1.6.- xref: UM-BBD_reactionID:r0602 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0018742 name: epoxide hydrolase B activity namespace: molecular_function def: "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [UM-BBD_enzymeID:e0051] xref: EC:3.3.2.- xref: UM-BBD_enzymeID:e0051 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0018743 name: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0560] xref: EC:3.3.2.- xref: UM-BBD_reactionID:r0560 is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity [Term] id: GO:0018744 name: limonene-1,2-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8] subset: gosubset_prok synonym: "limonene oxide hydrolase activity" EXACT [EC:3.3.2.8] xref: EC:3.3.2.8 xref: MetaCyc:3.3.2.8-RXN xref: UM-BBD_reactionID:r0734 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0018745 name: epoxide hydrolase A activity namespace: molecular_function def: "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [UM-BBD_enzymeID:e0049] xref: EC:3.3.2.- xref: UM-BBD_enzymeID:e0049 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0018746 name: phenanthrene-3,4-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0535] xref: EC:3.3.2.- xref: UM-BBD_reactionID:r0535 is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] id: GO:0018747 name: phenanthrene-1,2-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0536] xref: EC:3.3.2.- xref: UM-BBD_reactionID:r0536 is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] id: GO:0018748 name: iprodione amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [UM-BBD_reactionID:r0706] xref: EC:3.5.1.- xref: UM-BBD_reactionID:r0706 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0018749 name: (3,5-dichlorophenylurea)acetate amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [UM-BBD_reactionID:r0708] xref: EC:3.5.1.- xref: UM-BBD_reactionID:r0708 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0018750 name: biuret amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3." [EC:3.5.1.84] xref: EC:3.5.1.84 xref: UM-BBD_reactionID:r0846 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0018751 name: 3,5-dichlorophenylcarboximide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [UM-BBD_reactionID:r0707] xref: EC:3.5.2.- xref: UM-BBD_reactionID:r0707 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0018752 name: epsilon-caprolactam lactamase activity namespace: molecular_function def: "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_reactionID:r0448] xref: EC:3.5.2.- xref: MetaCyc:R561-RXN xref: UM-BBD_reactionID:r0448 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0018753 name: cyanuric acid amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2." [EC:3.5.2.15] subset: gosubset_prok xref: EC:3.5.2.15 xref: MetaCyc:R468-RXN xref: UM-BBD_reactionID:r0116 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0018754 name: ammelide aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3." [PMID:1991731] xref: EC:3.5.3.- xref: MetaCyc:RXN-8017 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018755 name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414] xref: EC:3.5.3.- is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018756 name: ammeline aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731] xref: EC:3.5.3.- xref: MetaCyc:RXN-8016 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018757 name: deisopropylhydroxyatrazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_reactionID:r0121] xref: EC:3.5.3.- xref: UM-BBD_reactionID:r0121 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018758 name: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [UM-BBD_reactionID:r0122] xref: EC:3.5.3.- xref: UM-BBD_reactionID:r0122 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018759 name: methenyltetrahydromethanopterin cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+)." [EC:3.5.4.27, RHEA:19056] subset: gosubset_prok synonym: "5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)" EXACT [EC:3.5.4.27] synonym: "5,10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "methenyl-H(4)MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "methenyl-H4MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] xref: EC:3.5.4.27 xref: KEGG:R03464 xref: MetaCyc:3.5.4.27-RXN xref: RHEA:19056 xref: UM-BBD_reactionID:r0347 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0018760 name: thiocyanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 H(+) + thiocyanate = carbonyl sulfide + NH(4)(+)." [EC:3.5.5.8, RHEA:21467] synonym: "thiocyanate aminohydrolase activity" EXACT [EC:3.5.5.8] xref: EC:3.5.5.8 xref: KEGG:R05780 xref: MetaCyc:RXN-1761 xref: RHEA:21467 xref: UM-BBD_reactionID:r0598 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0018761 name: bromoxynil nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H(2)O = 3,5-dibromo-4-hydroxybenzoate + NH(4)(+). Involved in the bacterial degradation of the herbicide bromoxynil." [EC:3.5.5.6, RHEA:22103] subset: gosubset_prok synonym: "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity" EXACT [] synonym: "bromoxynil-specific nitrilase activity" EXACT [] xref: EC:3.5.5.6 xref: KEGG:R04349 xref: MetaCyc:3.5.5.6-RXN xref: RHEA:22103 xref: UM-BBD_enzymeID:e0357 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0018762 name: aliphatic nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7] subset: gosubset_prok synonym: "aliphatic nitrile aminohydrolase activity" EXACT [EC:3.5.5.7] xref: EC:3.5.5.7 xref: MetaCyc:3.5.5.7-RXN xref: UM-BBD_reactionID:r0622 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0018763 name: hydroxydechloroatrazine ethylaminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.99.3] subset: gosubset_prok synonym: "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity" EXACT [EC:3.5.99.3] synonym: "AtzB" RELATED [EC:3.5.99.3] synonym: "hydroxyatrazine ethylaminohydrolase activity" EXACT [] synonym: "hydroxyatrazine hydrolase activity" EXACT [EC:3.5.99.3] xref: EC:3.5.99.3 xref: MetaCyc:R122-RXN xref: UM-BBD_enzymeID:e0085 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0018764 name: N-isopropylammelide isopropylaminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.99.4] subset: gosubset_prok synonym: "AtzC" RELATED [EC:3.5.99.4] xref: EC:3.5.99.4 xref: MetaCyc:R123-RXN xref: UM-BBD_enzymeID:e0086 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0018765 name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_reactionID:r0263] xref: EC:3.7.1.- xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN xref: UM-BBD_reactionID:r0263 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018766 name: dihydrophloroglucinol hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_reactionID:r0008] xref: EC:3.7.1.- xref: MetaCyc:R6-RXN xref: UM-BBD_reactionID:r0008 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018767 name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [UM-BBD_reactionID:r0399] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r0399 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018768 name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0458] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r0458 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018769 name: 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0311] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r0311 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018770 name: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+." [UM-BBD_reactionID:r0444] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r0444 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018771 name: 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity namespace: molecular_function alt_id: GO:0008680 def: "Catalysis of the reaction: 2-hydroxy-6-keto-nona-2,4-dienedioate + OH- = cis-2-hydroxypenta-2,4-dienoate + succinate." [UM-BBD_enzymeID:e0310] xref: EC:3.7.1.- xref: UM-BBD_enzymeID:e0310 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018772 name: trioxoheptanoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_reactionID:r0094] xref: EC:3.7.1.- xref: MetaCyc:R306-RXN xref: UM-BBD_reactionID:r0094 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018773 name: acetylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate." [EC:3.7.1.6, RHEA:16100] synonym: "2,4-dioxopentanoate acetylhydrolase activity" EXACT [EC:3.7.1.6] xref: EC:3.7.1.6 xref: KEGG:R00324 xref: MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN xref: RHEA:16100 xref: UM-BBD_reactionID:r0095 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018774 name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate." [EC:3.7.1.8] subset: gosubset_prok synonym: "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity" EXACT [EC:3.7.1.8] synonym: "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity" EXACT [] synonym: "HOHPDA hydrolase activity" EXACT [EC:3.7.1.8] xref: EC:3.7.1.8 xref: MetaCyc:3.7.1.8-RXN xref: UM-BBD_enzymeID:e0033 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018775 name: 2-hydroxymuconate-semialdehyde hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate." [EC:3.7.1.9] synonym: "2-hydroxymuconate-semialdehyde formylhydrolase activity" EXACT [EC:3.7.1.9] synonym: "2-hydroxymuconic semialdehyde hydrolase activity" EXACT [EC:3.7.1.9] synonym: "HMSH" RELATED [EC:3.7.1.9] synonym: "HOD hydrolase activity" EXACT [EC:3.7.1.9] xref: EC:3.7.1.9 xref: MetaCyc:3.7.1.9-RXN xref: UM-BBD_enzymeID:e0139 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018776 name: trans-chloroacrylic acid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [UM-BBD_reactionID:r0689] xref: EC:3.8.1.- xref: UM-BBD_reactionID:r0689 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018777 name: 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214] xref: EC:3.8.1.- is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018778 name: DL-2 haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [UM-BBD_reactionID:r0382] xref: EC:3.8.1.- xref: MetaCyc:RXN-9150 xref: UM-BBD_reactionID:r0382 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018779 name: 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. xref: EC:3.8.1.- xref: UM-BBD_enzymeID:e0100 is_obsolete: true [Term] id: GO:0018780 name: dichloroacetate halidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate." [UM-BBD_reactionID:r0383] xref: EC:3.8.1.- xref: UM-BBD_reactionID:r0383 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018781 name: S-triazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330] xref: EC:3.8.1.- xref: UM-BBD_enzymeID:e0091 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018782 name: cis-chloroacrylic acid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [UM-BBD_reactionID:r0688] xref: EC:3.8.1.- xref: UM-BBD_reactionID:r0688 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018783 name: deisopropyldeethylatrazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [UM-BBD_reactionID:0129] xref: EC:3.8.1.- is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018784 name: (S)-2-haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.2] subset: gosubset_prok synonym: "(S)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-haloacid dehalogenase activity" EXACT [] synonym: "2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-haloalkanoic acid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "2-haloalkanoid acid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-halocarboxylic acid dehalogenase II activity" EXACT [EC:3.8.1.2] synonym: "DL-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "halocarboxylic acid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "L-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "L-DEX activity" EXACT [EC:3.8.1.2] xref: EC:3.8.1.2 xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN xref: UM-BBD_reactionID:r0090 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018785 name: haloacetate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: haloacetate + H2O = glycolate + halide." [EC:3.8.1.3] subset: gosubset_prok synonym: "haloacetate halidohydrolase activity" EXACT [EC:3.8.1.3] synonym: "monohaloacetate dehalogenase activity" EXACT [EC:3.8.1.3] xref: EC:3.8.1.3 xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN xref: UM-BBD_enzymeID:e0006 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018786 name: haloalkane dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide." [EC:3.8.1.5] subset: gosubset_prok synonym: "1-chlorohexane halidohydrolase activity" EXACT [EC:3.8.1.5] synonym: "1-haloalkane dehalogenase activity" EXACT [EC:3.8.1.5] synonym: "1-haloalkane halidohydrolase activity" EXACT [EC:3.8.1.5] xref: EC:3.8.1.5 xref: MetaCyc:HALOALKANE-DEHALOGENASE-RXN xref: UM-BBD_enzymeID:e0003 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018787 name: 4-chlorobenzoyl-CoA dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride." [EC:3.8.1.7] synonym: "4-chlorobenzoyl CoA chlorohydrolase activity" EXACT [EC:3.8.1.7] xref: EC:3.8.1.7 xref: MetaCyc:3.8.1.7-RXN xref: UM-BBD_enzymeID:e0113 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018788 name: atrazine chlorohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: atrazine + H(2)O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H(+)." [EC:3.8.1.8, RHEA:11315] subset: gosubset_prok synonym: "AtzA" RELATED [EC:3.8.1.8] xref: EC:3.8.1.8 xref: KEGG:R05558 xref: MetaCyc:3.8.1.8-RXN xref: RHEA:11315 xref: UM-BBD_reactionID:r0113 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018789 name: cyclamate sulfohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexylsulfamate + H(2)O = cyclohexylamine + sulfate." [EC:3.10.1.2, RHEA:18484] synonym: "cyclamate sulfamatase activity" EXACT [] synonym: "cyclamate sulfamidase activity" EXACT [EC:3.10.1.2] synonym: "cyclamate sulphohydrolase activity" EXACT [] synonym: "cyclohexylsulfamate sulfamidase activity" EXACT [EC:3.10.1.2] synonym: "cyclohexylsulfamate sulfohydrolase activity" EXACT [EC:3.10.1.2] xref: EC:3.10.1.2 xref: KEGG:R02564 xref: MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN xref: RHEA:18484 xref: UM-BBD_reactionID:r0755 is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds [Term] id: GO:0018791 name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [UM-BBD_reactionID:r0398] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0398 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018792 name: bis(4-chlorophenyl)acetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [UM-BBD_reactionID:r0520] synonym: "DDA decarboxylase activity" EXACT [] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0520 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018793 name: 3,5-dibromo-4-hydroxybenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [UM-BBD_reactionID:r0546] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0546 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018794 name: 2-hydroxyisobutyrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [UM-BBD_reactionID:r0617] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0617 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018795 name: 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [UM-BBD_reactionID:r0621] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0621 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018796 name: 4,5-dihydroxyphthalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.55] subset: gosubset_prok synonym: "4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.55] synonym: "4,5-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.55] xref: EC:4.1.1.55 xref: MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN xref: UM-BBD_enzymeID:e0106 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018798 name: gallate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: gallate + H(+) = CO(2) + pyrogallol." [EC:4.1.1.59, RHEA:12752] synonym: "gallate carboxy-lyase (pyrogallol-forming)" EXACT [EC:4.1.1.59] synonym: "gallate carboxy-lyase activity" EXACT [EC:4.1.1.59] synonym: "gallic acid decarboxylase activity" EXACT [] xref: EC:4.1.1.59 xref: KEGG:R03247 xref: MetaCyc:GALLATE-DECARBOXYLASE-RXN xref: RHEA:12752 xref: UM-BBD_reactionID:r0005 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018799 name: 4-hydroxybenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + H(+) = CO(2) + phenol." [EC:4.1.1.61, RHEA:10879] subset: gosubset_prok synonym: "4-hydroxybenzoate carboxy-lyase (phenol-forming)" EXACT [EC:4.1.1.61] synonym: "4-hydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.61] synonym: "p-hydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.61] xref: EC:4.1.1.61 xref: KEGG:R01238 xref: MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN xref: RHEA:10879 xref: UM-BBD_reactionID:r0159 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018800 name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68] subset: gosubset_prok synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity" EXACT [EC:4.1.1.68] synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity" EXACT [] synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)" EXACT [EC:4.1.1.68] synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.68] synonym: "HpaG-2" RELATED [] synonym: "HpaG2" RELATED [] synonym: "OPET decarboxylase activity" EXACT [] xref: EC:4.1.1.68 xref: MetaCyc:4.1.1.68-RXN xref: UM-BBD_reactionID:r0367 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018801 name: glutaconyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: trans-glutaconyl-CoA + H(+) = but-2-enoyl-CoA + CO(2)." [EC:4.1.1.70, RHEA:23975] subset: gosubset_prok synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)" EXACT [EC:4.1.1.70] synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70] synonym: "glutaconyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.70] synonym: "pent-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70] xref: EC:4.1.1.70 xref: KEGG:R03028 xref: MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN xref: RHEA:23975 xref: UM-BBD_reactionID:r0199 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018802 name: 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [UM-BBD_reactionID:r0370] xref: EC:4.1.2.- xref: UM-BBD_reactionID:r0370 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018803 name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34] synonym: "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.34] synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] synonym: "2'-carboxybenzalpyruvate aldolase activity" EXACT [EC:4.1.2.34] synonym: "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity" EXACT [] xref: EC:4.1.2.34 xref: MetaCyc:4.1.2.34-RXN xref: UM-BBD_reactionID:r0487 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018805 name: benzylsuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate." [EC:4.1.99.11, RHEA:10419] synonym: "benzylsuccinate fumarate-lyase (toluene-forming)" EXACT [EC:4.1.99.11] synonym: "benzylsuccinate fumarate-lyase activity" EXACT [EC:4.1.99.11] xref: EC:4.1.99.11 xref: KEGG:R05598 xref: MetaCyc:RXN-863 xref: RHEA:10419 xref: UM-BBD_enzymeID:e0259 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0018807 name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0204] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r0204 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018808 name: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [UM-BBD_reactionID:r0484] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r0484 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018809 name: E-phenylitaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [UM-BBD_reactionID:r0331] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r0331 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018810 name: trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [UM-BBD_reactionID:r0164] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r0164 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018811 name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_reactionID:r0191] xref: EC:4.2.1.- xref: MetaCyc:R266-RXN xref: UM-BBD_reactionID:r0191 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018812 name: 3-hydroxyacyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA)." [UM-BBD_ruleID:bt0291] xref: EC:4.2.1.- is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018813 name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E )-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:e0257] xref: EC:4.2.1.- xref: UM-BBD_enzymeID:e0257 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018814 name: phenylacetaldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (trans)-phenylacetaldoxime = H(2)O + phenylacetonitrile." [EC:4.99.1.7, RHEA:20072] synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity" EXACT [EC:4.99.1.7] synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.7] synonym: "arylacetaldoxime dehydratase activity" EXACT [EC:4.99.1.7] synonym: "OxdB" RELATED [EC:4.99.1.7] synonym: "PAOx dehydratase activity" EXACT [EC:4.99.1.7] xref: EC:4.99.1.7 xref: KEGG:R07638 xref: MetaCyc:4.99.1.7-RXN xref: RHEA:20072 xref: UM-BBD_reactionID:r0697 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0018815 name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_reactionID:r0051] xref: EC:4.2.1.- xref: MetaCyc:RXN-645 xref: UM-BBD_reactionID:r0051 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018816 name: 2-hydroxyisobutyrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate." [UM-BBD_reactionID:r0618] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r0618 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018817 name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_reactionID:r0369] subset: gosubset_prok synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT [] synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT [] synonym: "HpaH" RELATED [] xref: EC:4.2.1.- xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN xref: UM-BBD_reactionID:r0369 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018818 name: acetylene hydratase activity namespace: molecular_function def: "Catalysis of the reaction: acetaldehyde = acetylene + H(2)O." [EC:4.2.1.112, RHEA:17888] synonym: "acetaldehyde hydro-lyase activity" EXACT [EC:4.2.1.112] synonym: "AH" RELATED [EC:4.2.1.112] synonym: "AHy" RELATED [EC:4.2.1.112] xref: EC:4.2.1.112 xref: KEGG:R05380 xref: MetaCyc:R141-RXN xref: RHEA:17888 xref: UM-BBD_reactionID:r0591 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018819 name: lactoyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O." [EC:4.2.1.54] synonym: "acrylyl coenzyme A hydratase activity" EXACT [EC:4.2.1.54] synonym: "lactoyl coenzyme A dehydratase activity" EXACT [EC:4.2.1.54] synonym: "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)" EXACT [EC:4.2.1.54] synonym: "lactoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.54] synonym: "lactyl CoA dehydratase activity" EXACT [EC:4.2.1.54] synonym: "lactyl-coenzyme A dehydrase activity" EXACT [EC:4.2.1.54] xref: EC:4.2.1.54 xref: MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN xref: MetaCyc:RXN-781 xref: UM-BBD_reactionID:r0086 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018820 name: cyanamide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: urea = cyanamide + H(2)O." [EC:4.2.1.69, RHEA:23059] synonym: "urea hydro-lyase (cyanamide-forming)" EXACT [EC:4.2.1.69] synonym: "urea hydro-lyase activity" EXACT [EC:4.2.1.69] xref: EC:4.2.1.69 xref: KEGG:R00778 xref: MetaCyc:CYANAMIDE-HYDRATASE-RXN xref: RHEA:23059 xref: UM-BBD_reactionID:r0668 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018822 name: nitrile hydratase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O." [EC:4.2.1.84] subset: gosubset_prok synonym: "3-cyanopyridine hydratase activity" EXACT [EC:4.2.1.84] synonym: "acrylonitrile hydratase activity" EXACT [EC:4.2.1.84] synonym: "aliphatic nitrile hydratase activity" EXACT [EC:4.2.1.84] synonym: "aliphatic-amide hydro-lyase (nitrile-forming)" EXACT [EC:4.2.1.84] synonym: "H-NHase activity" EXACT [EC:4.2.1.84] synonym: "L-NHase activity" EXACT [EC:4.2.1.84] synonym: "NHase activity" EXACT [EC:4.2.1.84] synonym: "nitrile hydro-lyase activity" EXACT [EC:4.2.1.84] xref: EC:4.2.1.84 xref: MetaCyc:NITRILE-HYDRATASE-RXN xref: UM-BBD_enzymeID:e0067 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018823 name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H(2)O = 6-hydroxycyclohex-1-enecarbonyl-CoA." [EC:4.2.1.100, RHEA:21859] subset: gosubset_prok synonym: "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)" RELATED [EC:4.2.1.100] synonym: "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [] synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [EC:4.2.1.100] synonym: "cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity" EXACT [EC:4.2.1.100] synonym: "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.100] synonym: "dienoyl-CoA hydratase activity" EXACT [EC:4.2.1.100] xref: EC:4.2.1.100 xref: KEGG:R05597 xref: MetaCyc:4.2.1.100-RXN xref: RHEA:21859 xref: UM-BBD_reactionID:r0203 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018824 name: (hydroxyamino)benzene mutase activity namespace: molecular_function def: "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_reactionID:r0304] synonym: "(hydroxyamino)benzene hydroxymutase activity" EXACT [EC:5.4.4.1] synonym: "HAB mutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene hydroxymutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene mutase activity" EXACT [EC:5.4.4.1] xref: MetaCyc:5.4.4.1-RXN xref: UM-BBD_reactionID:r0304 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0018825 name: triethanolamine lyase activity namespace: molecular_function def: "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [UM-BBD_enzymeID:e0421] xref: EC:4.3.3.- xref: UM-BBD_enzymeID:e0421 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0018826 name: methionine gamma-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate." [EC:4.4.1.11] subset: gosubset_prok synonym: "L-methioninase activity" EXACT [EC:4.4.1.11] synonym: "L-methionine gamma-lyase activity" EXACT [EC:4.4.1.11] synonym: "L-methionine methanethiol-lyase (deaminating)" EXACT [EC:4.4.1.11] synonym: "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.11] synonym: "methioninase activity" EXACT [EC:4.4.1.11] synonym: "methionine dethiomethylase activity" EXACT [EC:4.4.1.11] synonym: "methionine lyase activity" EXACT [EC:4.4.1.11] xref: EC:4.4.1.11 xref: MetaCyc:METHIONINE-GAMMA-LYASE-RXN xref: UM-BBD_reactionID:r0432 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0018827 name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_reactionID:r0515] synonym: "DDMS dehydrochlorinase activity" EXACT [] xref: EC:4.5.1.- xref: UM-BBD_reactionID:r0515 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018828 name: halohydrin hydrogen-halide-lyase A activity namespace: molecular_function def: "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0048] xref: EC:4.5.1.- xref: UM-BBD_enzymeID:e0048 is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity [Term] id: GO:0018829 name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0513] synonym: "DDD dehydrochlorinase activity" EXACT [] xref: EC:4.5.1.- xref: UM-BBD_reactionID:r0513 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018830 name: gamma-hexachlorocyclohexane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359] xref: EC:4.5.1.- xref: UM-BBD_enzymeID:e0359 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018831 name: 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_reactionID:r0666] xref: EC:4.5.1.- xref: UM-BBD_reactionID:r0666 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018832 name: halohydrin hydrogen-halide-lyase B activity namespace: molecular_function def: "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0050] xref: EC:4.5.1.- xref: UM-BBD_enzymeID:e0050 is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity [Term] id: GO:0018833 name: DDT-dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19220] synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]" RELATED [EC:4.5.1.1] synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity" EXACT [EC:4.5.1.1] synonym: "DDT dehydrochlorinase activity" EXACT [] synonym: "DDT-as" RELATED [EC:4.5.1.1] synonym: "DDT-ase activity" EXACT [EC:4.5.1.1] synonym: "DDTase activity" EXACT [EC:4.5.1.1] xref: EC:4.5.1.1 xref: KEGG:R04522 xref: MetaCyc:DDT-DEHYDROCHLORINASE-RXN xref: RHEA:19220 xref: UM-BBD_reactionID:r0439 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018834 name: dichloromethane dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+)." [EC:4.5.1.3, RHEA:15400] subset: gosubset_prok synonym: "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)" EXACT [EC:4.5.1.3] synonym: "dichloromethane chloride-lyase (chloride-hydrolysing)" EXACT [EC:4.5.1.3] xref: EC:4.5.1.3 xref: KEGG:R00603 xref: MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN xref: RHEA:15400 xref: UM-BBD_reactionID:r0188 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018835 name: carbon phosphorus lyase activity namespace: molecular_function alt_id: GO:0009456 def: "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [UM-BBD_enzymeID:e0057] xref: EC:4.99.1.- xref: UM-BBD_enzymeID:e0057 is_a: GO:0016829 ! lyase activity [Term] id: GO:0018836 name: alkylmercury lyase activity namespace: molecular_function def: "Catalysis of the reaction: R-Hg+ + H+ = R-H + Hg2+." [EC:4.99.1.2] subset: gosubset_prok synonym: "alkylmercury mercuric-lyase (alkane-forming)" EXACT [EC:4.99.1.2] synonym: "alkylmercury mercuric-lyase activity" EXACT [EC:4.99.1.2] synonym: "organomercurial lyase activity" EXACT [EC:4.99.1.2] synonym: "organomercury lyase activity" EXACT [EC:4.99.1.2] xref: EC:4.99.1.2 xref: MetaCyc:ALKYLMERCURY-LYASE-RXN xref: UM-BBD_enzymeID:e0055 is_a: GO:0016829 ! lyase activity [Term] id: GO:0018837 name: 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r0502] xref: EC:5.1.2.- xref: UM-BBD_reactionID:r0502 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0018838 name: mandelate racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-mandelate = (R)-mandelate." [EC:5.1.2.2] subset: gosubset_prok xref: EC:5.1.2.2 xref: MetaCyc:MANDELATE-RACEMASE-RXN xref: UM-BBD_reactionID:r0091 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0018839 name: cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0163] xref: EC:5.2.1.- xref: UM-BBD_reactionID:r0163 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0018842 name: 3-carboxymuconate cycloisomerase type II activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfomuconate = 4-sulfolactone." [UM-BBD_reactionID:r0582] subset: gosubset_prok xref: EC:5.3.3.- xref: UM-BBD_reactionID:r0582 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0018844 name: 2-hydroxytetrahydrofuran isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_reactionID:r0019] xref: EC:5.3.99.- xref: UM-BBD_reactionID:r0019 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0018845 name: 2-hydroxychromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate." [RHEA:27404] xref: EC:5.99.1.4 xref: KEGG:R05137 xref: MetaCyc:RXNN-386 xref: RHEA:27404 xref: UM-BBD_reactionID:r0337 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0018846 name: styrene-oxide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: styrene oxide = phenylacetaldehyde." [EC:5.3.99.7, RHEA:21607] synonym: "SOI activity" EXACT [EC:5.3.99.7] synonym: "styrene oxide isomerase activity" EXACT [] synonym: "styrene-oxide isomerase (epoxide-cleaving)" EXACT [EC:5.3.99.7] xref: EC:5.3.99.7 xref: KEGG:R02615 xref: MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN xref: RHEA:21607 xref: UM-BBD_reactionID:r0034 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0018847 name: alpha-pinene lyase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene = limonene." [UM-BBD_reactionID:r0712] xref: EC:5.5.1.- xref: UM-BBD_reactionID:r0712 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018848 name: pinocarveol isomerase activity namespace: molecular_function def: "Catalysis of the reaction: pinocarveol = carveol." [UM-BBD_reactionID:r0715] xref: EC:5.5.1.- xref: UM-BBD_reactionID:r0715 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018849 name: muconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [EC:5.5.1.1] subset: gosubset_prok synonym: "2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.1] synonym: "4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing)" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate cycloisomerase activity" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate lactonizing enzyme I activity" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate-lactonizing enzyme" RELATED [EC:5.5.1.1] synonym: "muconate cycloisomerase I activity" EXACT [EC:5.5.1.1] synonym: "muconate lactonizing enzyme activity" EXACT [EC:5.5.1.1] xref: EC:5.5.1.1 xref: MetaCyc:MUCONATE-CYCLOISOMERASE-RXN xref: UM-BBD_enzymeID:e0133 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018850 name: chloromuconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7] subset: gosubset_prok synonym: "2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.7] synonym: "muconate cycloisomerase II activity" EXACT [EC:5.5.1.7] xref: EC:5.5.1.7 xref: UM-BBD_enzymeID:e0065 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018851 name: alpha-pinene-oxide decyclase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10, RHEA:16696] synonym: "alpha-pinene oxide lyase activity" EXACT [] synonym: "alpha-pinene-oxide lyase (decyclizing)" EXACT [EC:5.5.1.10] xref: EC:5.5.1.10 xref: KEGG:R04040 xref: MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN xref: RHEA:16696 xref: UM-BBD_reactionID:r0743 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018852 name: dichloromuconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11] synonym: "2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.11] xref: EC:5.5.1.11 xref: MetaCyc:DICHLOROMUCONATE-CYCLOISOMERASE-RXN xref: UM-BBD_reactionID:r0277 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018853 name: perillyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_reactionID:r0731] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r0731 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018854 name: 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [UM-BBD_reactionID:r0737] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r0737 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018855 name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_reactionID:r0429] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r0429 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018856 name: benzoyl acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_reactionID:r0242] xref: EC:6.2.1.- xref: KEGG:R05452 xref: SABIO-RK:5058 xref: UM-BBD_reactionID:r0242 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018857 name: 2,4-dichlorobenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [UM-BBD_reactionID:r0137] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r0137 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018858 name: benzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate + H(+)." [EC:6.2.1.25, RHEA:10135] subset: gosubset_prok synonym: "benzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.25] synonym: "benzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.25] synonym: "benzoyl CoA synthetase (AMP forming)" EXACT [EC:6.2.1.25] synonym: "benzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.25] xref: EC:6.2.1.25 xref: KEGG:R01422 xref: MetaCyc:BENZOATE--COA-LIGASE-RXN xref: RHEA:10135 xref: UM-BBD_reactionID:r0189 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018859 name: 4-hydroxybenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27] subset: gosubset_prok synonym: "4-hydroxybenzoate-CoA synthetase activity" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoate-coenzyme A ligase (AMP-forming)" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoyl-CoA ligase activity" EXACT [EC:6.2.1.27] xref: EC:6.2.1.27 xref: KEGG:R01300 xref: MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN xref: UM-BBD_reactionID:r0156 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018860 name: anthranilate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32] subset: gosubset_prok synonym: "2-aminobenzoate coenzyme A ligase activity" EXACT [EC:6.2.1.32] synonym: "2-aminobenzoate-CoA ligase activity" EXACT [EC:6.2.1.32] synonym: "2-aminobenzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.32] synonym: "anthranilate--CoA ligase activity" EXACT [] synonym: "anthranilate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.32] synonym: "anthraniloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.32] xref: EC:6.2.1.32 xref: KEGG:R00982 xref: MetaCyc:AMINOBENZCOALIG-RXN xref: RHEA:10831 xref: UM-BBD_reactionID:r0341 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018861 name: 4-chlorobenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33] subset: gosubset_prok synonym: "4-chlorobenzoate:CoA ligase activity" EXACT [] xref: EC:6.2.1.33 xref: KEGG:R03932 xref: MetaCyc:6.2.1.33-RXN xref: RHEA:23223 xref: UM-BBD_reactionID:r0139 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018862 name: phenylphosphate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate." [UM-BBD_reactionID:r0157] xref: EC:6.4.1.- xref: MetaCyc:PHENYLPCARB-RXN xref: UM-BBD_reactionID:r0157 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0018863 name: phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0496] xref: EC:3.3.2.- xref: UM-BBD_reactionID:r0496 is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity [Term] id: GO:0018864 name: acetylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "acetylene metabolism" EXACT [] synonym: "ethyne metabolic process" EXACT [] synonym: "ethyne metabolism" EXACT [] xref: UM-BBD_pathwayID:atl is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043452 ! cellular alkyne metabolic process [Term] id: GO:0018865 name: acrylonitrile metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [http://www.iversonsoftware.com/reference/chemistry/a/acrylonitrile.htm] subset: gosubset_prok synonym: "acrylonitrile metabolism" EXACT [] xref: UM-BBD_pathwayID:acr is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018866 name: adamantanone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] subset: gosubset_prok synonym: "adamantanone metabolism" EXACT [] xref: UM-BBD_pathwayID:ada is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0018867 name: alpha-pinene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor." [http://umbbd.ahc.umn.edu/apn/apn_map.html, UM-BBD_pathwayID:apn] subset: gosubset_prok synonym: "alpha-pinene metabolism" EXACT [] xref: UM-BBD_pathwayID:apn is_a: GO:0033073 ! pinene metabolic process [Term] id: GO:0018868 name: 2-aminobenzenesulfonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [http://umbbd.ahc.umn.edu/abs/abs_map.html, UM-BBD_pathwayID:abs] subset: gosubset_prok synonym: "2-aminobenzenesulfonate metabolism" EXACT [] synonym: "2-aminobenzenesulphonate metabolic process" EXACT [] synonym: "2-aminobenzenesulphonate metabolism" EXACT [] xref: UM-BBD_pathwayID:abs is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018870 name: anaerobic 2-aminobenzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic 2-aminobenzoate metabolism" EXACT [] xref: UM-BBD_pathwayID:abz is_a: GO:0018875 ! anaerobic benzoate metabolic process is_a: GO:0043420 ! anthranilate metabolic process [Term] id: GO:0018871 name: 1-aminocyclopropane-1-carboxylate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [http://umbbd.ahc.umn.edu/acp/acp_map.html, UM-BBD_pathwayID:acp] subset: gosubset_prok synonym: "1-aminocyclopropane-1-carboxylate metabolism" EXACT [] synonym: "ACP metabolic process" EXACT [] synonym: "ACP metabolism" EXACT [] xref: UM-BBD_pathwayID:acp is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0018872 name: arsonoacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides." [http://umbbd.ahc.umn.edu/ara/ara_map.html, UM-BBD_pathwayID:ara] subset: gosubset_prok synonym: "arsonoacetate metabolism" EXACT [] xref: UM-BBD_pathwayID:ara is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0018873 name: atrazine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [http://umbbd.ahc.umn.edu/atr/atr_map.html, UM-BBD_pathwayID:atr] subset: gosubset_prok synonym: "atrazine metabolism" EXACT [] xref: UM-BBD_pathwayID:atr is_a: GO:0018965 ! s-triazine compound metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018874 name: benzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "benzoate metabolism" EXACT [] xref: MetaCyc:P321-PWY xref: UM-BBD_pathwayID:benz2 is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018875 name: anaerobic benzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic benzoate metabolism" EXACT [] xref: MetaCyc:CENTBENZCOA-PWY xref: UM-BBD_pathwayID:benz is_a: GO:0018874 ! benzoate metabolic process [Term] id: GO:0018876 name: benzonitrile metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin." [UM-BBD_pathwayID:bzn] subset: gosubset_prok synonym: "benzonitrile metabolism" EXACT [] xref: UM-BBD_pathwayID:bzn is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018877 name: beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:hch] subset: gosubset_prok synonym: "beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] xref: UM-BBD_pathwayID:hch is_a: GO:0019497 ! hexachlorocyclohexane metabolic process [Term] id: GO:0018878 name: aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] is_a: GO:0018877 ! beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process [Term] id: GO:0018879 name: biphenyl metabolic process namespace: biological_process def: "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GOC:jl] subset: gosubset_prok synonym: "biphenyl metabolism" EXACT [] synonym: "xenene metabolic process" EXACT [] synonym: "xenene metabolism" EXACT [] xref: UM-BBD_pathwayID:bph is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018880 name: 4-chlorobiphenyl metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation." [GOC:jl] subset: gosubset_prok synonym: "4-chlorobiphenyl metabolism" EXACT [] xref: UM-BBD_pathwayID:cbp is_a: GO:0018879 ! biphenyl metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018881 name: bromoxynil metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai] subset: gosubset_prok synonym: "bromoxynil metabolism" EXACT [] xref: UM-BBD_pathwayID:box is_a: GO:0042197 ! halogenated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018882 name: (+)-camphor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [http://umbbd.ahc.umn.edu/cam/cam_map.html, UM-BBD_pathwayID:cam] subset: gosubset_prok synonym: "(+)-camphor metabolism" EXACT [] synonym: "camphor metabolic process" EXACT [] synonym: "camphor metabolism" EXACT [] xref: UM-BBD_pathwayID:cam is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0043692 ! monoterpene metabolic process [Term] id: GO:0018883 name: caprolactam metabolic process namespace: biological_process def: "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation." [CHEBI:23000, GOC:curators] subset: gosubset_prok synonym: "caprolactam metabolism" EXACT [] xref: UM-BBD_pathwayID:cap is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0072338 ! cellular lactam metabolic process [Term] id: GO:0018884 name: carbazole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:jl] subset: gosubset_prok synonym: "CAR metabolic process" EXACT [] synonym: "CAR metabolism" EXACT [] synonym: "carbazole metabolism" EXACT [] xref: UM-BBD_pathwayID:car is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018885 name: carbon tetrachloride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [http://umbbd.ahc.umn.edu/ctc/ctc_map.html, UM-BBD_pathwayID:ctc] subset: gosubset_prok synonym: "carbon tetrachloride metabolism" EXACT [] xref: Reactome:1229977 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:1257760 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:1283359 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:1303792 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:1331270 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:1356208 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:1377220 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:1397404 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:1423455 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:76434 "Dehalogenation of carbon tetrachloride to form a free radical" xref: UM-BBD_pathwayID:ctc is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018886 name: anaerobic carbon tetrachloride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic carbon tetrachloride metabolism" EXACT [] xref: UM-BBD_pathwayID:ctc is_a: GO:0018885 ! carbon tetrachloride metabolic process [Term] id: GO:0018887 name: 4-carboxy-4'-sulfoazobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid." [PMID:9603860] subset: gosubset_prok synonym: "4-carboxy-4'-sulfoazobenzene metabolism" EXACT [] synonym: "4-carboxy-4'-sulphoazobenzene metabolic process" EXACT [] synonym: "4-carboxy-4'-sulphoazobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:csab is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018888 name: 3-chloroacrylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid." [GOC:ai] subset: gosubset_prok synonym: "3-chloroacrylic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:caa is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018889 name: 2-chloro-N-isopropylacetanilide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [http://umbbd.ahc.umn.edu/ppc/ppc_map.html, UM-BBD_pathwayID:ppc] subset: gosubset_prok synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT [] synonym: "propachlor metabolic process" EXACT [] synonym: "propachlor metabolism" EXACT [] xref: UM-BBD_pathwayID:ppc is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018890 name: cyanamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism." [CHEBI:16698, GOC:curators] subset: gosubset_prok synonym: "cyanamide metabolism" EXACT [] xref: UM-BBD_pathwayID:cnm is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018891 name: cyclohexanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "cyclohexanol metabolism" EXACT [] xref: UM-BBD_pathwayID:chx is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0018892 name: cyclohexylsulfamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide." [UM-BBD_pathwayID:chs] subset: gosubset_prok synonym: "cyclohexylsulfamate metabolism" EXACT [] synonym: "cyclohexylsulphamate metabolic process" EXACT [] synonym: "cyclohexylsulphamate metabolism" EXACT [] xref: UM-BBD_pathwayID:chs is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0018893 name: dibenzofuran metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." [GOC:ai, UM-BBD_pathwayID:dbf] subset: gosubset_prok synonym: "dibenzofuran metabolism" EXACT [] xref: UM-BBD_pathwayID:dbf is_a: GO:0018904 ! organic ether metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018894 name: dibenzo-p-dioxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern." [UM-BBD_pathwayID:dpd] subset: gosubset_prok synonym: "dibenzo-p-dioxin metabolism" EXACT [] synonym: "oxanthrene metabolic process" EXACT [] synonym: "oxanthrene metabolism" EXACT [] synonym: "phenodioxin metabolic process" EXACT [] synonym: "phenodioxin metabolism" EXACT [] xref: UM-BBD_pathwayID:dpd is_a: GO:0018904 ! organic ether metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018895 name: dibenzothiophene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion." [PMID:12147483] subset: gosubset_prok synonym: "dibenzothiophene metabolism" EXACT [] synonym: "diphenylene sulfide metabolic process" EXACT [] synonym: "diphenylene sulfide metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018896 name: dibenzothiophene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] subset: gosubset_prok synonym: "dibenzothiophene breakdown" EXACT [] synonym: "dibenzothiophene catabolism" EXACT [] synonym: "dibenzothiophene degradation" EXACT [] xref: UM-BBD_pathwayID:dbt2 is_a: GO:0018895 ! dibenzothiophene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0018897 name: dibenzothiophene desulfurization namespace: biological_process def: "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] subset: gosubset_prok synonym: "dibenzothiophene desulphurization" EXACT [] xref: MetaCyc:PWY-681 xref: UM-BBD_pathwayID:dbt is_a: GO:0018895 ! dibenzothiophene metabolic process [Term] id: GO:0018898 name: 2,4-dichlorobenzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:jl, http://umbbd.ahc.umn.edu/dcb/dcb_map.html, UM-BBD_pathwayID:dcb] subset: gosubset_prok synonym: "2,4-dichlorobenzoate metabolism" EXACT [] xref: UM-BBD_pathwayID:dcb is_a: GO:0018874 ! benzoate metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018899 name: 1,2-dichloroethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:jl] subset: gosubset_prok synonym: "1,2-dichloroethane metabolism" EXACT [] xref: UM-BBD_pathwayID:dce is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018900 name: dichloromethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover." [UM-BBD_pathwayID:dcm] subset: gosubset_prok synonym: "dichloromethane metabolism" EXACT [] xref: UM-BBD_pathwayID:dcm is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018901 name: 2,4-dichlorophenoxyacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UM-BBD_pathwayID:2\,4d] subset: gosubset_prok synonym: "2,4-D metabolic process" EXACT [] synonym: "2,4-D metabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:2\,4-d is_a: GO:0018904 ! organic ether metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018902 name: 1,3-dichloro-2-propanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers." [GOC:jl, http://umbbd.ahc.umn.edu/dcp/dcp_map.html, UM-BBD_pathwayID:dcp] subset: gosubset_prok synonym: "1,3-dichloro-2-propanol metabolism" EXACT [] synonym: "DCP metabolic process" EXACT [] synonym: "DCP metabolism" EXACT [] xref: UM-BBD_pathwayID:dcp is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process [Term] id: GO:0018903 name: 1,3-dichloropropene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes." [http://umbbd.ahc.umn.edu/cpr/cpr_map.html, UM-BBD_pathwayID:cpr] subset: gosubset_prok synonym: "1,3-dichloropropene metabolism" EXACT [] synonym: "1,3-dichloropropylene metabolic process" EXACT [] synonym: "1,3-dichloropropylene metabolism" EXACT [] synonym: "gamma-chloroallylchloride metabolic process" EXACT [] synonym: "gamma-chloroallylchloride metabolism" EXACT [] xref: UM-BBD_pathwayID:cpr is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018904 name: organic ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "organic ether metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0018905 name: dimethyl ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications." [UM-BBD_pathwayID:dme] subset: gosubset_prok synonym: "dimethyl ether metabolism" EXACT [] synonym: "methyl ether metabolic process" EXACT [] synonym: "methyl ether metabolism" EXACT [] xref: UM-BBD_pathwayID:dme is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018904 ! organic ether metabolic process [Term] id: GO:0018906 name: methyl tert-butyl ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent." [UM-BBD_pathwayID:mtb] subset: gosubset_prok synonym: "methyl tert-butyl ether metabolism" EXACT [] xref: UM-BBD_pathwayID:mtb is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018904 ! organic ether metabolic process [Term] id: GO:0018907 name: dimethyl sulfoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing." [CHEBI:28262, GOC:curators] subset: gosubset_prok synonym: "dimethyl sulfoxide metabolism" EXACT [] synonym: "dimethyl sulphoxide metabolic process" EXACT [] synonym: "dimethyl sulphoxide metabolism" EXACT [] synonym: "DMSO metabolic process" EXACT [] synonym: "DMSO metabolism" EXACT [] xref: UM-BBD_pathwayID:sulf is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0018908 name: organosulfide cycle namespace: biological_process def: "A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle." [UM-BBD_pathwayID:sulf] subset: gosubset_prok synonym: "organosulphide cycle" EXACT [] xref: UM-BBD_pathwayID:sulf is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0018909 name: dodecyl sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants." [UM-BBD_pathwayID:dds] subset: gosubset_prok synonym: "dodecyl sulfate metabolism" EXACT [] synonym: "dodecyl sulphate metabolic process" EXACT [] synonym: "dodecyl sulphate metabolism" EXACT [] xref: UM-BBD_pathwayID:dds is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0018910 name: benzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation." [CHEBI:16716, GOC:ai] subset: gosubset_prok synonym: "benzene metabolism" EXACT [] xref: Reactome:1229975 "Benzene is hydroxylated to phenol" xref: Reactome:1257758 "Benzene is hydroxylated to phenol" xref: Reactome:1283357 "Benzene is hydroxylated to phenol" xref: Reactome:1303790 "Benzene is hydroxylated to phenol" xref: Reactome:1331268 "Benzene is hydroxylated to phenol" xref: Reactome:1356207 "Benzene is hydroxylated to phenol" xref: Reactome:1377218 "Benzene is hydroxylated to phenol" xref: Reactome:1397402 "Benzene is hydroxylated to phenol" xref: Reactome:1423454 "Benzene is hydroxylated to phenol" xref: Reactome:76416 "Benzene is hydroxylated to phenol" is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018911 name: 1,2,4-trichlorobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides." [http://www.speclab.com/compound/c120821.htm] subset: gosubset_prok synonym: "1,2,4-trichlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:tbz is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018912 name: 1,4-dichlorobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm] subset: gosubset_prok synonym: "1,4-dichlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:dcz is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018913 name: anaerobic ethylbenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic ethylbenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:ethb is_a: GO:0018915 ! ethylbenzene metabolic process [Term] id: GO:0018914 name: chlorobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." [http://www.shsu.edu/] subset: gosubset_prok synonym: "chlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:cb is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018915 name: ethylbenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels." [http://www.speclab.com/compound/c100414.htm] subset: gosubset_prok synonym: "ethylbenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:ethb2 is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018916 name: nitrobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline." [CHEBI:27798, GOC:curators] subset: gosubset_prok synonym: "nitrobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:nb is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018917 name: fluorene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [http://umbbd.ahc.umn.edu/flu/flu_map.html, UM-BBD_pathwayID:flu] subset: gosubset_prok synonym: "fluorene metabolism" EXACT [] xref: UM-BBD_pathwayID:flu is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018918 name: gallate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). The esters and polyesters are widely distributed in angiosperms." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "gallate metabolism" EXACT [] synonym: "gallic acid metabolic process" EXACT [] synonym: "gallic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:gal is_a: GO:0009712 ! catechol metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0018919 name: gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:ghch] subset: gosubset_prok synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] xref: MetaCyc:GAMMAHEXCHLORDEG-PWY xref: UM-BBD_pathwayID:ghch is_a: GO:0019497 ! hexachlorocyclohexane metabolic process [Term] id: GO:0018920 name: glyphosate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond." [http://umbbd.ahc.umn.edu/gly/gly_map.html, UM-BBD_pathwayID:gly] subset: gosubset_prok synonym: "glyphosate metabolism" EXACT [] synonym: "Roundup metabolic process" EXACT [] synonym: "Roundup metabolism" EXACT [] xref: UM-BBD_pathwayID:gly is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0018921 name: 3-hydroxybenzyl alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum." [http://umbbd.ahc.umn.edu/mcr/mcr_map.html, UM-BBD_pathwayID:mcr] subset: gosubset_prok synonym: "3-hydroxybenzyl alcohol metabolism" EXACT [] xref: UM-BBD_pathwayID:mcr is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0018922 name: iprodione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [http://umbbd.ahc.umn.edu/ipd/ipd_map.html, UM-BBD_pathwayID:ipd] subset: gosubset_prok synonym: "iprodione metabolism" EXACT [] xref: UM-BBD_pathwayID:ipd is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018923 name: limonene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [http://umbbd.ahc.umn.edu/lim/lim_map.html, UM-BBD_pathwayID:lim] subset: gosubset_prok synonym: "limonene metabolism" EXACT [] xref: UM-BBD_pathwayID:lim is_a: GO:0043692 ! monoterpene metabolic process [Term] id: GO:0018924 name: mandelate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:jl] subset: gosubset_prok synonym: "mandelate metabolism" EXACT [] synonym: "mandelic acid metabolic process" EXACT [] synonym: "mandelic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:mca is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0018925 name: m-cresol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes." [GOC:jl] subset: gosubset_prok synonym: "3-hydroxytoluene metabolic process" EXACT [] synonym: "3-hydroxytoluene metabolism" EXACT [] synonym: "m-cresol metabolism" EXACT [] synonym: "meta-cresol metabolic process" EXACT [] synonym: "meta-cresol metabolism" EXACT [] xref: MetaCyc:M-CRESOL-DEGRADATION-PWY xref: UM-BBD_pathwayID:mcr is_a: GO:0042212 ! cresol metabolic process [Term] id: GO:0018926 name: methanesulfonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide." [UM-BBD_pathwayID:msa] subset: gosubset_prok synonym: "methanesulfonic acid metabolism" EXACT [] synonym: "methanesulphonic acid metabolic process" EXACT [] synonym: "methanesulphonic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:msa is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0018927 name: methionine and threonine metabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because its use of 'and' was causing violations to the true-path rule. is_obsolete: true consider: GO:0006555 consider: GO:0006566 [Term] id: GO:0018928 name: methyl ethyl ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [http://umbbd.ahc.umn.edu/mek/mek_map.html, UM-BBD_pathwayID:mek] subset: gosubset_prok synonym: "2-butanone metabolic process" EXACT [] synonym: "2-butanone metabolism" EXACT [] synonym: "MEK metabolic process" EXACT [] synonym: "MEK metabolism" EXACT [] synonym: "methyl ethyl ketone metabolism" EXACT [] xref: UM-BBD_pathwayID:mek is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0018929 name: methyl fluoride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils." [UM-BBD_pathwayID:mf] subset: gosubset_prok synonym: "methyl fluoride metabolism" EXACT [] xref: UM-BBD_pathwayID:mf is_a: GO:0042197 ! halogenated hydrocarbon metabolic process [Term] id: GO:0018930 name: 3-methylquinoline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] subset: gosubset_prok synonym: "3-methylquinoline metabolism" EXACT [] xref: UM-BBD_pathwayID:mqn is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018931 name: naphthalene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide." [http://www.iversonsoftware.com/reference/chemistry/n/Naphthalene.htm] subset: gosubset_prok synonym: "naphthalene metabolism" EXACT [] xref: UM-BBD_pathwayID:naph is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018933 name: nicotine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] subset: gosubset_prok synonym: "nicotine metabolism" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018934 name: nitrilotriacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment." [UM-BBD_pathwayID:nta] subset: gosubset_prok synonym: "nitrilotriacetate metabolism" EXACT [] xref: UM-BBD_pathwayID:nta is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0018935 name: aerobic nitrilotriacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "aerobic nitrilotriacetate metabolism" EXACT [] is_a: GO:0018934 ! nitrilotriacetate metabolic process [Term] id: GO:0018936 name: anaerobic nitrilotriacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic nitrilotriacetate metabolism" EXACT [] is_a: GO:0018934 ! nitrilotriacetate metabolic process [Term] id: GO:0018937 name: nitroglycerin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates." [http://umbbd.ahc.umn.edu/ng/ng_map.html, UM-BBD_pathwayID:ng] subset: gosubset_prok synonym: "NG metabolic process" EXACT [] synonym: "NG metabolism" EXACT [] synonym: "nitroglycerin metabolism" EXACT [] xref: MetaCyc:P201-PWY xref: UM-BBD_pathwayID:ng is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0018938 name: 2-nitropropane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol." [http://umbbd.ahc.umn.edu/npp/npp_map.html, UM-BBD_pathwayID:npp] subset: gosubset_prok synonym: "2-nitropropane metabolism" EXACT [] xref: MetaCyc:PWY-723 xref: UM-BBD_pathwayID:npp is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0043446 ! cellular alkane metabolic process [Term] id: GO:0018939 name: n-octane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System." [UM-BBD_pathwayID:oct] subset: gosubset_prok synonym: "n-octane metabolism" EXACT [] xref: UM-BBD_pathwayID:oct is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043446 ! cellular alkane metabolic process [Term] id: GO:0018940 name: orcinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants." [GOC:jl] subset: gosubset_prok synonym: "orcin metabolic process" EXACT [] synonym: "orcin metabolism" EXACT [] synonym: "orcinol metabolism" EXACT [] xref: MetaCyc:P342-PWY xref: UM-BBD_pathwayID:orc is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0034311 ! diol metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018941 name: organomercury metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "organomercury metabolism" EXACT [] xref: UM-BBD_pathwayID:ogm is_a: GO:0018942 ! organometal metabolic process [Term] id: GO:0018942 name: organometal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "organometal metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0018943 name: organotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organotin, an organic compound containing a tin atom." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "organotin metabolism" EXACT [] is_a: GO:0018942 ! organometal metabolic process [Term] id: GO:0018944 name: tri-n-butyltin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms." [GOC:ai, UM-BBD_pathwayID:tbt] subset: gosubset_prok synonym: "tri-n-butyltin metabolism" EXACT [] xref: UM-BBD_pathwayID:tbt is_a: GO:0018943 ! organotin metabolic process [Term] id: GO:0018945 name: organosilicon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon." [GOC:jl] subset: gosubset_prok synonym: "organosilicon metabolism" EXACT [] synonym: "organosilicone metabolic process" EXACT [] synonym: "organosilicone metabolism" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0018946 name: aerobic organosilicon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen." [GOC:jl] subset: gosubset_prok synonym: "aerobic organosilicon metabolism" EXACT [] synonym: "aerobic organosilicone metabolic process" EXACT [] synonym: "aerobic organosilicone metabolism" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0018945 ! organosilicon metabolic process [Term] id: GO:0018947 name: anaerobic organosilicon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen." [GOC:jl] subset: gosubset_prok synonym: "anaerobic organosilicon metabolism" EXACT [] synonym: "anaerobic organosilicone metabolic process" EXACT [] synonym: "anaerobic organosilicone metabolism" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0018945 ! organosilicon metabolic process [Term] id: GO:0018948 name: xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:jl] subset: gosubset_prok synonym: "xylene metabolism" EXACT [] is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018949 name: m-xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] subset: gosubset_prok synonym: "m-xylene metabolism" EXACT [] synonym: "meta-xylene metabolic process" EXACT [] synonym: "meta-xylene metabolism" EXACT [] xref: UM-BBD_pathwayID:mxy is_a: GO:0018948 ! xylene metabolic process [Term] id: GO:0018950 name: o-xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] subset: gosubset_prok synonym: "o-xylene metabolism" EXACT [] synonym: "ortho-xylene metabolic process" EXACT [] synonym: "ortho-xylene metabolism" EXACT [] xref: UM-BBD_pathwayID:oxy is_a: GO:0018948 ! xylene metabolic process [Term] id: GO:0018951 name: p-xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] subset: gosubset_prok synonym: "p-xylene metabolism" EXACT [] synonym: "para-xylene metabolic process" EXACT [] synonym: "para-xylene metabolism" EXACT [] xref: UM-BBD_pathwayID:pxy is_a: GO:0018948 ! xylene metabolic process [Term] id: GO:0018952 name: parathion metabolic process namespace: biological_process def: "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [http://umbbd.ahc.umn.edu/pthn/pthn_map.html, UM-BBD_pathwayID:pthn] subset: gosubset_prok synonym: "parathion metabolism" EXACT [] xref: UM-BBD_pathwayID:pthn is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018953 name: p-cymene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [UM-BBD_pathwayID:pcy] subset: gosubset_prok synonym: "p-cymene metabolism" EXACT [] xref: UM-BBD_pathwayID:pcy is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018954 name: pentaerythritol tetranitrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator." [UM-BBD_pathwayID:petn] subset: gosubset_prok synonym: "pentaerythritol tetranitrate metabolism" EXACT [] xref: UM-BBD_pathwayID:petn is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0018955 name: phenanthrene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish." [GOC:jl, http://umbbd.ahc.umn.edu/pha/pha_map.html, UM-BBD_pathwayID:pha] subset: gosubset_prok synonym: "phenanthrene metabolism" EXACT [] xref: UM-BBD_pathwayID:pha is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018956 name: phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite." [http://umbbd.ahc.umn.edu/pha3/pha3_map.html, UM-BBD_pathwayID:pha3] subset: gosubset_prok synonym: "phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] synonym: "phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] xref: UM-BBD_pathwayID:pha3 is_a: GO:0042216 ! phenanthrene catabolic process [Term] id: GO:0018957 name: phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite." [http://umbbd.ahc.umn.edu/pha2/pha2_map.html, UM-BBD_pathwayID:pha2] subset: gosubset_prok synonym: "phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] synonym: "phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] xref: UM-BBD_pathwayID:pha2 is_a: GO:0042216 ! phenanthrene catabolic process [Term] id: GO:0018958 name: phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [CHEBI:33853, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. subset: gosubset_prok synonym: "carbolic acid metabolic process" EXACT [] synonym: "carbolic acid metabolism" EXACT [] synonym: "hydroxybenzene metabolic process" EXACT [] synonym: "hydroxybenzene metabolism" EXACT [] synonym: "phenol-containing compound metabolism" EXACT [GOC:curators] xref: UM-BBD_pathwayID:phe is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018959 name: aerobic phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [CHEBI:33853, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aerobic phenol-containing compound metabolism" EXACT [GOC:curators] xref: UM-BBD_pathwayID:pba is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0018960 name: 4-nitrophenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:jl] subset: gosubset_prok synonym: "4-nitrophenol metabolism" EXACT [] synonym: "p-nitrophenol metabolic process" EXACT [] synonym: "p-nitrophenol metabolism" EXACT [] xref: UM-BBD_pathwayID:nphe is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0018961 name: pentachlorophenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [http://umbbd.ahc.umn.edu/pcp/pcp_map.html, UM-BBD_pathwayID:pcp] subset: gosubset_prok synonym: "PCP metabolic process" EXACT [] synonym: "PCP metabolism" EXACT [] synonym: "pentachlorophenol metabolism" EXACT [] xref: UM-BBD_pathwayID:pcp is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018962 name: 3-phenylpropionate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins." [GOC:ai, UM-BBD_pathwayID:ppa] subset: gosubset_prok synonym: "3-phenylpropionate metabolism" EXACT [] synonym: "hydrocinnamic acid metabolic process" EXACT [] synonym: "hydrocinnamic acid metabolism" EXACT [] synonym: "phenylpropanoate metabolic process" EXACT [] synonym: "phenylpropanoate metabolism" EXACT [] xref: UM-BBD_pathwayID:ppa is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018963 name: phthalate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses." [http://umbbd.ahc.umn.edu/pth/pth_map.html, UM-BBD_pathwayID:pth] subset: gosubset_prok synonym: "phthalate metabolism" EXACT [] synonym: "phthalic acid metabolic process" EXACT [] synonym: "phthalic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:pth is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0018964 name: propylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals." [GOC:jl] subset: gosubset_prok synonym: "propylene metabolism" EXACT [] xref: UM-BBD_pathwayID:pro is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0018965 name: s-triazine compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [http://umbbd.ahc.umn.edu/tria/tria_map.html, UM-BBD_pathwayID:tria] subset: gosubset_prok synonym: "s-triazine compound metabolism" EXACT [] xref: UM-BBD_pathwayID:tria is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018966 name: styrene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen." [GOC:jl, http://umbbd.ahc.umn.edu/sty/sty_map.html, UM-BBD_pathwayID:sty] subset: gosubset_prok synonym: "styrene metabolism" EXACT [] xref: UM-BBD_pathwayID:sty is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0018967 name: tetrachloroethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent." [http://www.who.int/water_sanitation_health/GDWQ/Chemicals/tetrachloroethenesum.htm] subset: gosubset_prok synonym: "tetrachloroethene metabolic process" EXACT [] synonym: "tetrachloroethene metabolism" EXACT [] synonym: "tetrachloroethylene metabolism" EXACT [] xref: UM-BBD_pathwayID:tce2 is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0018968 name: tetrahydrofuran metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems." [UM-BBD_pathwayID:thf] subset: gosubset_prok synonym: "tetrahydrofuran metabolism" EXACT [] synonym: "THF metabolic process" EXACT [] synonym: "THF metabolism" EXACT [] xref: UM-BBD_pathwayID:thf is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018904 ! organic ether metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018969 name: thiocyanate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries." [GOC:jl] subset: gosubset_prok synonym: "thiocyanate metabolism" EXACT [] synonym: "thiocyanic acid metabolic process" EXACT [] synonym: "thiocyanic acid metabolism" EXACT [] xref: MetaCyc:P581-PWY xref: UM-BBD_pathwayID:thc is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0018970 name: toluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [http://umbbd.ahc.umn.edu/tol/tol_map.html, UM-BBD_pathwayID:tol] subset: gosubset_prok synonym: "methylbenzene metabolic process" EXACT [] synonym: "methylbenzene metabolism" EXACT [] synonym: "toluene metabolism" EXACT [] is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018971 name: anaerobic toluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic toluene metabolism" EXACT [] xref: UM-BBD_pathwayID:tol2 is_a: GO:0018970 ! toluene metabolic process [Term] id: GO:0018972 name: toluene-4-sulfonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water." [GOC:ai] subset: gosubset_prok synonym: "4-methylbenzenesulfonate metabolic process" EXACT [] synonym: "4-methylbenzenesulfonate metabolism" EXACT [] synonym: "4-toluenesulfonate metabolic process" EXACT [] synonym: "4-toluenesulfonate metabolism" EXACT [] synonym: "toluene-4-sulfonate metabolism" EXACT [] synonym: "toluene-4-sulphonate metabolic process" EXACT [] synonym: "toluene-4-sulphonate metabolism" EXACT [] xref: MetaCyc:TOLSULFDEG-PWY xref: UM-BBD_pathwayID:tsa is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018973 name: trinitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] subset: gosubset_prok synonym: "trinitrotoluene metabolism" EXACT [] xref: UM-BBD_pathwayID:tnt is_a: GO:0019326 ! nitrotoluene metabolic process [Term] id: GO:0018974 name: 2,4,6-trinitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives." [ISBN:0333781767] subset: gosubset_prok synonym: "2,4,6-trinitrotoluene metabolism" EXACT [] synonym: "TNT metabolic process" EXACT [] synonym: "TNT metabolism" EXACT [] is_a: GO:0018973 ! trinitrotoluene metabolic process [Term] id: GO:0018975 name: anaerobic 2,4,6-trinitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic 2,4,6-trinitrotoluene metabolism" EXACT [] xref: UM-BBD_pathwayID:tnt2 is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0018976 name: 1,2,3-tribromopropane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture." [GOC:jl] subset: gosubset_prok synonym: "1,2,3-tribromopropane metabolism" EXACT [] xref: UM-BBD_pathwayID:tbp is_a: GO:0042197 ! halogenated hydrocarbon metabolic process [Term] id: GO:0018977 name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl] subset: gosubset_prok synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] synonym: "DDT metabolic process" EXACT [] synonym: "DDT metabolism" EXACT [] xref: UM-BBD_pathwayID:ddt is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process relationship: part_of GO:0046680 ! response to DDT [Term] id: GO:0018978 name: anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen." [GOC:jl] subset: gosubset_prok synonym: "anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] synonym: "anaerobic DDT metabolic process" EXACT [] synonym: "anaerobic DDT metabolism" EXACT [] xref: UM-BBD_pathwayID:ddt2 is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process [Term] id: GO:0018979 name: trichloroethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:jl] subset: gosubset_prok synonym: "TCE metabolic process" EXACT [] synonym: "TCE metabolism" EXACT [] synonym: "trichloroethene metabolic process" EXACT [] synonym: "trichloroethene metabolism" EXACT [] synonym: "trichloroethylene metabolism" EXACT [] xref: UM-BBD_pathwayID:tce is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018980 name: 2,4,5-trichlorophenoxyacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns." [UM-BBD_pathwayID:2\,4\,5-t] subset: gosubset_prok synonym: "2,4,5-T metabolic process" EXACT [] synonym: "2,4,5-T metabolism" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:2\,4\,5-t is_a: GO:0018904 ! organic ether metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018981 name: triethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:jl] subset: gosubset_prok synonym: "triethanolamine metabolism" EXACT [] xref: UM-BBD_pathwayID:tea is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044106 ! cellular amine metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process [Term] id: GO:0018982 name: vanillin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin." [GOC:jl] subset: gosubset_prok synonym: "vanillic aldehyde metabolic process" EXACT [] synonym: "vanillic aldehyde metabolism" EXACT [] synonym: "vanillin metabolism" EXACT [] xref: UM-BBD_pathwayID:van is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process [Term] id: GO:0018983 name: Z-phenylacetaldoxime metabolic process namespace: biological_process def: "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [http://umbbd.ahc.umn.edu/car/car_map.html, UM-BBD_pathwayID:car] subset: gosubset_prok synonym: "Z-phenylacetaldoxime metabolism" EXACT [] xref: UM-BBD_pathwayID:pao is_a: GO:0019330 ! aldoxime metabolic process [Term] id: GO:0018984 name: naphthalenesulfonate metabolic process namespace: biological_process alt_id: GO:0018932 def: "The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene." [GOC:ai] subset: gosubset_prok synonym: "naphthalenesulfonate metabolism" EXACT [] synonym: "naphthalenesulphonate metabolic process" EXACT [] synonym: "naphthalenesulphonate metabolism" EXACT [] xref: UM-BBD_pathwayID:nphs is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0018931 ! naphthalene metabolic process [Term] id: GO:0018985 name: pronuclear envelope synthesis namespace: biological_process def: "Synthesis and ordering of the envelope of pronuclei." [GOC:ems] is_a: GO:0006998 ! nuclear envelope organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0018988 name: molting cycle, protein-based cuticle namespace: biological_process def: "The periodic shedding of part or all of a protein-based cuticle, which is then replaced by a new protein-based cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss." [GOC:ems, GOC:mtg_sensu] synonym: "protein-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0042303 ! molting cycle [Term] id: GO:0018989 name: apolysis namespace: biological_process def: "The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells." [GOC:jl] xref: Wikipedia:Apolysis is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0018990 name: ecdysis, chitin-based cuticle namespace: biological_process def: "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0042394 ! ecdysis, protein-based cuticle relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0018991 name: oviposition namespace: biological_process def: "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems] synonym: "egg laying" BROAD [] synonym: "egg-laying" BROAD [] xref: Wikipedia:Oviposition is_a: GO:0033057 ! multicellular organismal reproductive behavior [Term] id: GO:0018992 name: germ-line sex determination namespace: biological_process def: "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0018993 name: somatic sex determination namespace: biological_process def: "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0018995 name: host namespace: cellular_component def: "Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "host organism" EXACT [] xref: Wikipedia:Host_(biology) is_a: GO:0044215 ! other organism [Term] id: GO:0018996 name: molting cycle, collagen and cuticulin-based cuticle namespace: biological_process def: "The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu] synonym: "collagen and cuticulin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0018988 ! molting cycle, protein-based cuticle [Term] id: GO:0018997 name: electron transfer carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the parent terms cover its function. is_obsolete: true consider: GO:0009055 [Term] id: GO:0018998 name: metaxin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0005741 [Term] id: GO:0019000 name: endonuclease G activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12444964, PMID:12928502, PMID:12941691] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004520 consider: GO:0004521 [Term] id: GO:0019001 name: guanyl nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:6405 "guanyl nucleotide binding" is_a: GO:0017076 ! purine nucleotide binding [Term] id: GO:0019002 name: GMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GMP, guanosine monophosphate." [GOC:ai] is_a: GO:0032561 ! guanyl ribonucleotide binding [Term] id: GO:0019003 name: GDP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate." [GOC:ai] is_a: GO:0032561 ! guanyl ribonucleotide binding [Term] id: GO:0019005 name: SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "CDL1 complex" EXACT [] synonym: "CRL1 complex" EXACT [] synonym: "Cul1-RING ubiquitin ligase complex" EXACT [] synonym: "cullin-RING ligase 1" EXACT [] synonym: "SCF complex" EXACT [] synonym: "SCF complex substrate recognition subunit" NARROW [] synonym: "Skp1/Cul1/F-box protein complex" EXACT [] xref: Wikipedia:SCF_complex is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0019008 name: molybdopterin synthase complex namespace: cellular_component alt_id: GO:0019009 def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] subset: gosubset_prok synonym: "molybdopterin converting factor complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0019010 name: farnesoic acid O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499] synonym: "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity" EXACT [] is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0019011 name: DNA replication accessory factor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. is_obsolete: true consider: GO:0006260 [Term] id: GO:0019012 name: virion namespace: cellular_component def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325] subset: goslim_pir synonym: "complete virus particle" EXACT [] xref: Wikipedia:Virus is_a: GO:0005575 ! cellular_component [Term] id: GO:0019013 name: viral nucleocapsid namespace: cellular_component alt_id: GO:0019014 def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] synonym: "core" BROAD [] synonym: "nucleocapsid" EXACT [] is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0019015 name: viral genome namespace: cellular_component def: "The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0044423 ! virion part [Term] id: GO:0019016 name: non-segmented viral genome namespace: cellular_component def: "A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk] is_a: GO:0019015 ! viral genome [Term] id: GO:0019017 name: segmented viral genome namespace: cellular_component def: "A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336] is_a: GO:0019015 ! viral genome [Term] id: GO:0019018 name: bipartite viral genome namespace: cellular_component def: "A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] is_a: GO:0019017 ! segmented viral genome [Term] id: GO:0019019 name: tripartite viral genome namespace: cellular_component def: "A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] is_a: GO:0019017 ! segmented viral genome [Term] id: GO:0019020 name: multipartite viral genome namespace: cellular_component def: "A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] is_a: GO:0019017 ! segmented viral genome [Term] id: GO:0019021 name: DNA viral genome namespace: cellular_component def: "A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336] is_a: GO:0019015 ! viral genome [Term] id: GO:0019022 name: RNA viral genome namespace: cellular_component def: "A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336] is_a: GO:0019015 ! viral genome [Term] id: GO:0019023 name: dsRNA viral genome namespace: cellular_component def: "A viral genome composed of double stranded RNA." [ISBN:0121585336] is_a: GO:0019022 ! RNA viral genome [Term] id: GO:0019024 name: ssRNA viral genome namespace: cellular_component def: "A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336] is_a: GO:0019022 ! RNA viral genome [Term] id: GO:0019025 name: positive sense viral genome namespace: cellular_component def: "A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336] is_a: GO:0019024 ! ssRNA viral genome [Term] id: GO:0019026 name: negative sense viral genome namespace: cellular_component def: "A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336] is_a: GO:0019024 ! ssRNA viral genome [Term] id: GO:0019027 name: ambisense viral genome namespace: cellular_component def: "A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336] is_a: GO:0019024 ! ssRNA viral genome [Term] id: GO:0019028 name: viral capsid namespace: cellular_component alt_id: GO:0046728 def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Capsid is_a: GO:0044423 ! virion part [Term] id: GO:0019029 name: helical viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X] is_a: GO:0019028 ! viral capsid [Term] id: GO:0019030 name: icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Tobacco satellite necrosis virus has such a capsid structure." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:071673706X] synonym: "quasispherical viral capsid" EXACT [] is_a: GO:0019028 ! viral capsid [Term] id: GO:0019031 name: viral envelope namespace: cellular_component def: "The lipid bilayer and associated glycoproteins that surround many types of virus particle." [ISBN:0781718325] synonym: "viral glycoprotein" RELATED [] synonym: "viral membrane" EXACT [] xref: Wikipedia:Viral_envelope is_a: GO:0044423 ! virion part [Term] id: GO:0019032 name: viral glycoprotein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a type of gene product and not a location or complex. is_obsolete: true consider: GO:0019031 [Term] id: GO:0019033 name: viral tegument namespace: cellular_component def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: Wikipedia:Viral_tegument is_a: GO:0044423 ! virion part [Term] id: GO:0019034 name: viral replication complex namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0019035 name: viral integration complex namespace: cellular_component def: "Virus-specific complex of protein required for integrating viral genomes into the host genome." [ISBN:0781718325] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0019036 name: viral transcriptional complex namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0019037 name: viral assembly intermediate namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0019038 name: provirus namespace: cellular_component def: "The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336] xref: Wikipedia:Provirus is_a: GO:0019015 ! viral genome is_a: GO:0044427 ! chromosomal part [Term] id: GO:0019039 name: viral-cell fusion molecule activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0019064 consider: GO:0050839 [Term] id: GO:0019040 name: viral host shutoff protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0004534 consider: GO:0019057 [Term] id: GO:0019042 name: latent virus infection namespace: biological_process def: "A viral process characterized by (a) the lack of efficient expression of all the viral genes that are transcribed during productive infection, and (b) the activation of a unique latent transcriptional progam." [ISBN:0781702534] is_a: GO:0022415 ! viral reproductive process [Term] id: GO:0019043 name: establishment of viral latency namespace: biological_process def: "The process in which a virus reaches a latent state." [ISBN:0781702534] synonym: "lysogenic commitment" EXACT [] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019042 ! latent virus infection [Term] id: GO:0019044 name: latent virus maintenance namespace: biological_process def: "Any process required for maintaining the latent form of the viral genome within a cell." [ISBN:0781718325] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019042 ! latent virus infection [Term] id: GO:0019045 name: latent virus replication namespace: biological_process def: "Any process required for latent viral replication in a cell." [ISBN:0781702534] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019042 ! latent virus infection [Term] id: GO:0019046 name: reactivation of latent virus namespace: biological_process def: "The reactivation of a virus from a latent to a lytic state." [ISBN:0781702534] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019042 ! latent virus infection [Term] id: GO:0019047 name: provirus integration namespace: biological_process def: "The molecular events that lead to the integration of a viral genome into the host genome." [ISBN:0121585336] synonym: "prophage integration" EXACT [] xref: Reactome:162592 "Integration of provirus" xref: Reactome:175567 "Integration of viral DNA into host genomic DNA" is_a: GO:0006310 ! DNA recombination is_a: GO:0015074 ! DNA integration is_a: GO:0022415 ! viral reproductive process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030069 ! lysogeny [Term] id: GO:0019048 name: virus-host interaction namespace: biological_process def: "Interactions, directly with the host cell macromolecular machinery, to allow virus replication." [ISBN:0781718325] synonym: "viral interaction with host" EXACT [] xref: Reactome:168253 "Host Interactions with Influenza Factors" is_a: GO:0022415 ! viral reproductive process is_a: GO:0051701 ! interaction with host [Term] id: GO:0019049 name: evasion of host defenses by virus namespace: biological_process def: "Any process, either active or passive, by which a virus avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:1555811272] synonym: "viral host defence evasion" EXACT [] synonym: "viral host defense evasion" EXACT [] is_a: GO:0019048 ! virus-host interaction is_a: GO:0044415 ! evasion or tolerance of host defenses [Term] id: GO:0019050 name: suppression by virus of host apoptosis namespace: biological_process def: "Any viral process that results in the inhibition of apoptosis, facilitating prolonged cell survival during viral replication." [ISBN:0781718325] synonym: "negative regulation by virus of host apoptosis" EXACT [] synonym: "negative regulation of apoptosis by virus" EXACT [] synonym: "suppression of apoptosis in host by virus" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0033668 ! negative regulation by symbiont of host apoptosis [Term] id: GO:0019051 name: induction by virus of host apoptosis namespace: biological_process def: "The set of viral processes that result in the induction of apoptosis of infected cells, facilitating release and spread of progeny virions." [ISBN:0781718325] synonym: "activation by virus of host apoptosis" EXACT [] synonym: "activation by virus of host apoptotic programmed cell death" EXACT [] synonym: "activation of apoptosis in host by virus" EXACT [] synonym: "induction by virus of host apoptotic programmed cell death" EXACT [] synonym: "induction of apoptosis in host by virus" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0052030 ! induction by symbiont of host apoptosis is_a: GO:0060139 ! positive regulation of apoptosis by virus [Term] id: GO:0019052 name: suppression by virus of host intracellular antiviral response namespace: biological_process def: "Any viral process that results in the inhibition of intracellular (innate immune response) antiviral mechanisms, thereby facilitating viral replication." [GOC:pk] synonym: "negative regulation by virus of intracellular antiviral response" EXACT [] synonym: "negative regulation of host intracellular antiviral response by virus" EXACT [] synonym: "suppression of host intracellular antiviral response by virus" EXACT [] synonym: "viral inhibition of intracellular antiviral response" EXACT [] is_a: GO:0019049 ! evasion of host defenses by virus is_a: GO:0050687 ! negative regulation of defense response to virus is_a: GO:0050690 ! regulation of defense response to virus by virus [Term] id: GO:0019053 name: suppression by virus of host extracellular antiviral response namespace: biological_process def: "Any viral process that results in the inhibition of extracellular (adaptive immune response) antiviral mechanisms, thereby facilitating viral replication." [GOC:pk] synonym: "inhibition of extracellular antiviral response" EXACT [] synonym: "negative regulation by virus of extracellular antiviral response" EXACT [] synonym: "negative regulation of host extracellular antiviral response by virus" EXACT [] synonym: "suppression of host extracellular antiviral response by virus" EXACT [] is_a: GO:0019049 ! evasion of host defenses by virus is_a: GO:0050687 ! negative regulation of defense response to virus is_a: GO:0050690 ! regulation of defense response to virus by virus [Term] id: GO:0019054 name: modulation by virus of host cellular process namespace: biological_process def: "The process in which a virus effects a change in the cellular pathways and activities of its host organism." [GOC:mah, GOC:pk] synonym: "modification by virus of host cellular process" EXACT [] synonym: "modulation of cellular process in host by virus" RELATED [] synonym: "regulation by virus of host cellular process" EXACT [] synonym: "regulation of cellular process in host by virus" EXACT [] synonym: "regulation of host cellular process by virus" EXACT [] synonym: "viral host cell process manipulation" EXACT [] xref: Reactome:168276 "NS1 Mediated Effects on Host Pathways" is_a: GO:0019048 ! virus-host interaction is_a: GO:0044068 ! modulation by symbiont of host cellular process [Term] id: GO:0019055 name: modification by virus of host cell cycle regulation namespace: biological_process def: "Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication." [GOC:dph, ISBN:0781718325] synonym: "viral perturbation of cell cycle regulation" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process [Term] id: GO:0019056 name: modulation by virus of host transcription namespace: biological_process def: "The modulation by viral gene products of host RNA polymerase II facilitated transcription." [ISBN:0781718325] synonym: "modification by virus of host transcription" EXACT [] synonym: "viral perturbation of host cell transcription" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0052026 ! modulation by symbiont of host transcription [Term] id: GO:0019057 name: modulation of host translation by virus namespace: biological_process def: "Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA." [ISBN:0781718325] synonym: "host cell protein synthesis shutoff" BROAD [] synonym: "host cell shutoff" BROAD [] synonym: "modification by virus of host cell mRNA translation" EXACT [] synonym: "regulation of host mRNA translation by virus" EXACT [] synonym: "regulation of host translation by virus" EXACT [] synonym: "regulation of translation in host by virus" EXACT [] synonym: "viral host shutoff protein" RELATED [] synonym: "viral perturbation of host cell mRNA translation" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0044073 ! modulation by symbiont of host translation [Term] id: GO:0019058 name: viral infectious cycle namespace: biological_process def: "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] synonym: "lytic viral life cycle" RELATED [] xref: Reactome:168254 "Influenza Infection" is_a: GO:0022415 ! viral reproductive process [Term] id: GO:0019059 name: initiation of viral infection namespace: biological_process def: "The set of processes involved in the start of virus infection of cells." [ISBN:0781702534] xref: Reactome:162594 "Early Phase of HIV Life Cycle" is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019058 ! viral infectious cycle [Term] id: GO:0019060 name: intracellular transport of viral proteins in host cell namespace: biological_process def: "The directed movement of viral proteins within the host cell." [ISBN:0781702534] synonym: "intracellular viral protein transport" EXACT [] xref: Reactome:168869 "Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol" xref: Reactome:168871 "Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus" xref: Reactome:168874 "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus" xref: Reactome:168884 "Entry of HA into the endoplasmic reticulum" is_a: GO:0022415 ! viral reproductive process is_a: GO:0030581 ! symbiont intracellular protein transport in host relationship: part_of GO:0046719 ! regulation of viral protein levels in host cell [Term] id: GO:0019061 name: uncoating of virus namespace: biological_process def: "A general term applied to the events that occur after penetration; refers to the 'uncoating' of the viral genome from the nucleocapsid core." [ISBN:0781702534] synonym: "viral uncoating" EXACT [] xref: Reactome:162585 "Uncoating of the HIV Virion" xref: Reactome:168299 "Ribonucleoprotein release from M1 proteins" xref: Reactome:168313 "Virion-associated M2 protein mediated ion infusion" xref: Reactome:168336 "Uncoating of the Influenza Virion" is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019059 ! initiation of viral infection [Term] id: GO:0019062 name: virion attachment to host cell surface receptor namespace: biological_process def: "Any process involved in the specific binding of a viral antireceptor to a cell surface receptor." [ISBN:0781702534] synonym: "virion attachment" EXACT [] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0046718 ! entry of virus into host cell [Term] id: GO:0019063 name: virion penetration into host cell namespace: biological_process def: "Any process required for the introduction of virus particles into the cell." [ISBN:0781702534] synonym: "virion penetration" EXACT [] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0046718 ! entry of virus into host cell [Term] id: GO:0019064 name: viral envelope fusion with host membrane namespace: biological_process def: "A form of viral penetration which involves the fusion of the virion envelope with the cellular membrane." [ISBN:0781702534] synonym: "viral envelope fusion" BROAD [] synonym: "viral envelope fusion with host cell membrane" EXACT [] synonym: "viral envelope fusion with host plasma membrane" EXACT [] synonym: "viral-cell fusion molecule activity" RELATED [] xref: Reactome:164524 "Fusion of viral membrane with host cell membrane" xref: Reactome:168288 "Fusion of the Influenza Virion to the Host Cell Endosome" xref: Reactome:168306 "Concerted hemagglutinin pore formation" xref: Reactome:168312 "Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane" is_a: GO:0019063 ! virion penetration into host cell is_a: GO:0061025 ! membrane fusion [Term] id: GO:0019065 name: receptor-mediated endocytosis of virus by host namespace: biological_process def: "A receptor-mediated endocytosis process in which a host cell takes up a virus particle; successive instances of virus endocytosis result in the accumulation of virus particles within the cell." [GOC:mah, ISBN:0781702534] synonym: "receptor mediated endocytosis by host of virus particle" EXACT [] synonym: "receptor mediated endocytosis of virus by host" EXACT [] synonym: "receptor mediated endocytosis of virus particle by host" EXACT [] synonym: "viral receptor mediated endocytosis" EXACT [] xref: Reactome:168275 "Entry of Influenza Virion into Host Cell via Endocytosis" xref: Reactome:168285 "Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion" is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0019063 ! virion penetration into host cell [Term] id: GO:0019066 name: translocation of virus into host cell namespace: biological_process def: "The translocation of an entire virus particle across the host cell plasma membrane." [ISBN:0781702534] synonym: "viral translocation" EXACT [] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019063 ! virion penetration into host cell [Term] id: GO:0019067 name: viral assembly, maturation, egress, and release namespace: biological_process def: "Any process involved in the assembly, maturation, egress, and release of progeny virions." [ISBN:1555811272] xref: Reactome:168268 "Virus Assembly and Release" is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019058 ! viral infectious cycle [Term] id: GO:0019068 name: virion assembly namespace: biological_process def: "A late phase of viral replication during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed." [ISBN:0121585336] synonym: "viral assembly" EXACT [] synonym: "viral particle assembly" EXACT [] synonym: "virus assembly" EXACT [GOC:dph, GOC:tb] synonym: "virus particle assembly" EXACT [] xref: Reactome:168302 "Budding" xref: Reactome:168316 "Assembly of Viral Components at the Budding Site" xref: Reactome:168862 "Association of HA into rafts" xref: Reactome:168882 "Association of NP into rafts" xref: Reactome:168894 "Accumulation of M1 at the inner leaflet of the lipid bilayer" is_a: GO:0022415 ! viral reproductive process is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release [Term] id: GO:0019069 name: viral capsid assembly namespace: biological_process def: "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534] is_a: GO:0022415 ! viral reproductive process is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0019070 name: viral genome maturation namespace: biological_process def: "Any viral process that occurs on newly synthesized viral genomes." [GOC:pk] xref: Reactome:168330 "Viral RNP Complexes in the Host Cell Nucleus" is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0019071 name: viral DNA cleavage namespace: biological_process def: "The cleavage of viral DNA into singular functional units." [ISBN:0121585336] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019070 ! viral genome maturation [Term] id: GO:0019072 name: viral genome packaging namespace: biological_process def: "The encapsulation of the viral genome within the capsid." [ISBN:0121585336] xref: Reactome:168303 "Packaging of Eight RNA Segments" xref: Reactome:168895 "RNP association" is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0019073 name: viral DNA genome packaging namespace: biological_process def: "The packing of viral DNA into a capsid." [ISBN:0781702534] is_a: GO:0006323 ! DNA packaging is_a: GO:0019072 ! viral genome packaging is_a: GO:0048610 ! cellular process involved in reproduction [Term] id: GO:0019074 name: viral RNA genome packaging namespace: biological_process def: "The packaging of viral RNA into a nucleocapsid." [ISBN:0781718325] is_a: GO:0019072 ! viral genome packaging [Term] id: GO:0019075 name: virus maturation namespace: biological_process def: "The assembly of the component viral parts into an infectious virion." [ISBN:0781718325] synonym: "viral maturation" EXACT [] synonym: "viral particle maturation" EXACT [] synonym: "virus particle maturation" RELATED [] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release [Term] id: GO:0019076 name: release of virus from host namespace: biological_process def: "The process in which a virus becomes free of a host cell either by the lysis of the host cell or by a non-lytic mechanism." [ISBN:0781702534] synonym: "viral release" EXACT [] xref: Reactome:168298 "Release" xref: Reactome:168870 "Neuraminidase enzymatic release from sialic acid" is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release [Term] id: GO:0019077 name: lytic viral release namespace: biological_process def: "A viral infection and replication that leads to the destruction (lysis) of the infected cell with the release of virions." [GOC:pk] synonym: "lytic viral life cycle" RELATED [] is_a: GO:0019076 ! release of virus from host [Term] id: GO:0019078 name: lytic viral budding namespace: biological_process def: "A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment." [ISBN:0781702534] is_a: GO:0019077 ! lytic viral release [Term] id: GO:0019079 name: viral genome replication namespace: biological_process def: "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534] synonym: "sigma virus replication" NARROW [] synonym: "viral replication" BROAD [] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019058 ! viral infectious cycle [Term] id: GO:0019080 name: viral genome expression namespace: biological_process def: "The achievement of highly specific, quantitative, temporal and spatial control of virus gene expression within the limited genetic resources of the viral genome." [ISBN:0121585336] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019058 ! viral infectious cycle [Term] id: GO:0019081 name: viral protein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of viral proteins." [ISBN:0781702534] synonym: "viral protein anabolism" EXACT [] synonym: "viral protein biosynthesis" EXACT [] synonym: "viral protein formation" EXACT [] synonym: "viral protein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0019080 ! viral genome expression [Term] id: GO:0019082 name: viral protein processing namespace: biological_process def: "The posttranslational processing of viral proteins." [ISBN:0781702534] xref: Reactome:168858 "Palmitoylation of cysteine residues on HA in the cis-Golgi network" xref: Reactome:168875 "Trimerization of HA" is_a: GO:0016485 ! protein processing relationship: part_of GO:0019080 ! viral genome expression [Term] id: GO:0019083 name: viral transcription namespace: biological_process def: "The mechanisms involved in viral gene transcription, especially referring to those with temporal properties unique to viral transcription." [ISBN:0781702534] xref: Reactome:167172 "Transcription of the HIV genome" xref: Reactome:168273 "Influenza Viral RNA Transcription and Replication" xref: Reactome:168280 "Priming and Initiation of Transcription" xref: Reactome:168301 "Polyadenylation and Termination" xref: Reactome:168325 "Viral Messenger RNA Synthesis" xref: Reactome:168326 "Assembly of an Active Transcription Complex" xref: Reactome:168334 "Elongation of viral mRNA" is_a: GO:0032774 ! RNA biosynthetic process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0019080 ! viral genome expression [Term] id: GO:0019084 name: (delayed) early viral mRNA transcription namespace: biological_process def: "The second round of viral gene transcription; most genes transcribed in this round are necessary for genome replication." [ISBN:0781702534] synonym: "beta protein" RELATED [] is_a: GO:0009299 ! mRNA transcription is_a: GO:0019083 ! viral transcription [Term] id: GO:0019085 name: immediate early viral mRNA transcription namespace: biological_process def: "The transcriptional period of the earliest expressed viral genes, mainly encoding transcriptional regulators." [ISBN:0781702534] synonym: "alpha protein" BROAD [] is_a: GO:0009299 ! mRNA transcription is_a: GO:0019083 ! viral transcription [Term] id: GO:0019086 name: late viral mRNA transcription namespace: biological_process def: "The last group of viral genes to be transcribed during the viral life cycle; genes consist mainly of those encoding structural proteins." [ISBN:0781702534] synonym: "gamma protein" RELATED [] is_a: GO:0009299 ! mRNA transcription is_a: GO:0019083 ! viral transcription [Term] id: GO:0019087 name: transformation of host cell by virus namespace: biological_process def: "Any virus-induced change in the morphological, biochemical, or growth parameters of a cell." [ISBN:0781702534] synonym: "viral transformation" EXACT [] synonym: "viral transformation of host cell" EXACT [] xref: Wikipedia:Viral_transformation is_a: GO:0019048 ! virus-host interaction is_a: GO:0044003 ! modification by symbiont of host morphology or physiology [Term] id: GO:0019088 name: immortalization of host cell by virus namespace: biological_process def: "A virus-induced cellular transformation arising in immortalized cells, or cells capable of indefinite replication, due to their ability to produce their own telomerase." [ISBN:0781702534] synonym: "viral immortalization" EXACT [] is_a: GO:0019087 ! transformation of host cell by virus is_a: GO:0020021 ! immortalization of host cell [Term] id: GO:0019089 name: transmission of virus namespace: biological_process def: "The transfer of virions in order to create new infection." [ISBN:0781702534] synonym: "viral transmission" EXACT [] is_a: GO:0022415 ! viral reproductive process is_a: GO:0044007 ! dissemination or transmission of symbiont from host [Term] id: GO:0019090 name: mitochondrial rRNA export from mitochondrion namespace: biological_process def: "The directed movement of mitochondrial rRNA out of a mitochondrion." [GOC:ai] synonym: "export of mitochondrial rRNA" BROAD [] synonym: "mitochondrial rRNA export" EXACT [] synonym: "mitochondrial rRNA export from mitochondria" EXACT [] synonym: "mitochondrial rRNA export out of mitochondrion" EXACT [] synonym: "mitochondrial rRNA transport from mitochondrion" EXACT [] synonym: "mitochondrial rRNA, mitochondrial export" EXACT [] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0019093 ! mitochondrial RNA localization is_a: GO:0050658 ! RNA transport [Term] id: GO:0019091 name: mitochondrial lrRNA export from mitochondrion namespace: biological_process def: "The directed movement of mitochondrial lrRNA out of a mitochondrion." [GOC:ai] synonym: "export of mitochondrial lrRNA" BROAD [] synonym: "mitochondrial lrRNA export" EXACT [] synonym: "mitochondrial lrRNA export from mitochondria" EXACT [] synonym: "mitochondrial lrRNA export out of mitochondrion" EXACT [] synonym: "mitochondrial lrRNA transport from mitochondrion" EXACT [] synonym: "mitochondrial lrRNA, mitochondrial export" EXACT [] is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion [Term] id: GO:0019092 name: mitochondrial srRNA export from mitochondrion namespace: biological_process def: "The directed movement of mitochondrial srRNA out of a mitochondrion." [GOC:ai] synonym: "export of mitochondrial srRNA" BROAD [] synonym: "mitochondrial srRNA export" EXACT [] synonym: "mitochondrial srRNA export from mitochondria" EXACT [] synonym: "mitochondrial srRNA export out of mitochondrion" EXACT [] synonym: "mitochondrial srRNA transport from mitochondrion" EXACT [] synonym: "mitochondrial srRNA, mitochondrial export" EXACT [] is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion [Term] id: GO:0019093 name: mitochondrial RNA localization namespace: biological_process def: "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT [] synonym: "mitochondrial RNA localisation" EXACT [GOC:mah] synonym: "mtRNA localization" EXACT [] is_a: GO:0006403 ! RNA localization [Term] id: GO:0019094 name: pole plasm mRNA localization namespace: biological_process alt_id: GO:0048120 def: "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of mRNA localization in pole plasm" EXACT [] synonym: "establishment and maintenance of pole plasm mRNA localization" EXACT [] synonym: "oocyte pole plasm mRNA localization" EXACT [] synonym: "pole granule RNA localization" BROAD [] synonym: "pole plasm mRNA localisation" EXACT [GOC:mah] is_a: GO:0007316 ! pole plasm RNA localization is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification [Term] id: GO:0019095 name: pole plasm mitochondrial rRNA localization namespace: biological_process alt_id: GO:0048117 def: "Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] synonym: "establishment and maintenance of mitochondrial rRNA localization in pole plasm" EXACT [] synonym: "oocyte pole plasm mitochondrial rRNA localization" EXACT [] synonym: "pole plasm mitochondrial rRNA localisation" EXACT [GOC:mah] is_a: GO:0007316 ! pole plasm RNA localization is_a: GO:0019093 ! mitochondrial RNA localization [Term] id: GO:0019096 name: pole plasm mitochondrial lrRNA localization namespace: biological_process alt_id: GO:0048118 def: "Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] synonym: "establishment and maintenance of mitochondrial lrRNA localization in pole plasm" EXACT [] synonym: "oocyte pole plasm mitochondrial lrRNA localization" EXACT [] synonym: "pole plasm mitochondrial lrRNA localisation" EXACT [GOC:mah] is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization [Term] id: GO:0019097 name: pole plasm mitochondrial srRNA localization namespace: biological_process alt_id: GO:0048119 def: "Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] synonym: "establishment and maintenance of mitochondrial localization in pole plasm" EXACT [] synonym: "oocyte pole plasm mitochondrial srRNA localization" EXACT [] synonym: "pole plasm mitochondrial srRNA localisation" EXACT [GOC:mah] is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization [Term] id: GO:0019098 name: reproductive behavior namespace: biological_process def: "The specific actions or reactions of an organism that are associated with reproduction." [GOC:jl] synonym: "reproductive behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0022414 ! reproductive process [Term] id: GO:0019099 name: female germ-line sex determination namespace: biological_process alt_id: GO:0007544 def: "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah] synonym: "sex determination, female germ-line determination" EXACT [] is_a: GO:0007542 ! primary sex determination, germ-line is_a: GO:0018992 ! germ-line sex determination is_a: GO:0030237 ! female sex determination [Term] id: GO:0019100 name: male germ-line sex determination namespace: biological_process def: "The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah] is_a: GO:0007542 ! primary sex determination, germ-line is_a: GO:0018992 ! germ-line sex determination is_a: GO:0030238 ! male sex determination [Term] id: GO:0019101 name: female somatic sex determination namespace: biological_process def: "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah] is_a: GO:0018993 ! somatic sex determination is_a: GO:0030237 ! female sex determination [Term] id: GO:0019102 name: male somatic sex determination namespace: biological_process def: "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah] is_a: GO:0018993 ! somatic sex determination is_a: GO:0030238 ! male sex determination [Term] id: GO:0019103 name: pyrimidine nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate." [GOC:ai] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0019104 name: DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0008578 def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] subset: gosubset_prok synonym: "DNA glycosylase activity" EXACT [] synonym: "endonuclease VIII activity" RELATED [] xref: EC:3.2.2.- xref: Reactome:7370 "DNA N-glycosylase activity" is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0019105 name: N-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0016409 ! palmitoyltransferase activity is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0019107 name: myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1.- xref: Reactome:2349 "myristoyltransferase activity" is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0019108 name: aryl-aldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+." [EC:1.2.1.29] synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.29] xref: EC:1.2.1.29 xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0394 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0019111 name: phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate." [EC:2.8.2.-] synonym: "phenanthrol sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0019112 name: phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O." [GOC:ai] xref: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0019113 name: limonene monooxygenase activity namespace: molecular_function def: "Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene." [GOC:mah] xref: EC:1.14.13.- is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0019114 name: catechol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = a muconate." [GOC:mah, MetaCyc:CATECHOL-12-DIOXYGENASE-RXN, MetaCyc:CATECHOL-23-DIOXYGENASE-RXN] subset: gosubset_prok xref: EC:1.13.11.- is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0019115 name: benzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+." [EC:1.2.1.28, EC:1.2.1.7] subset: gosubset_prok xref: EC:1.2.1.- is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0019116 name: hydroxy-nicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide." [GOC:jl, http://umbbd.ahc.umn.edu/] subset: gosubset_prok xref: EC:1.5.3.- is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0019117 name: dihydroxyfluorene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid." [GOC:mah, UM-BBD_reactionID:r0415, UM-BBD_reactionID:r0422] xref: EC:1.13.11.- is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0019118 name: phenanthrene-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536] xref: EC:3.3.2.- is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0019119 name: phenanthrene-9,10-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560] xref: EC:3.3.2.- is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] id: GO:0019120 name: hydrolase activity, acting on acid halide bonds, in C-halide compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.8.1 is_a: GO:0016824 ! hydrolase activity, acting on acid halide bonds [Term] id: GO:0019121 name: peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine namespace: biological_process def: "The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan." [RESID:AA0218] subset: gosubset_prok xref: RESID:AA0218 is_a: GO:0018104 ! peptidoglycan-protein cross-linking is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0019122 name: peptidyl-D-alanine racemization namespace: biological_process def: "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine." [RESID:AA0191] comment: See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'. subset: gosubset_prok synonym: "alanine racemization" BROAD [] xref: RESID:AA0191 is_a: GO:0018085 ! peptidyl-L-amino acid racemization is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0019123 name: peptidyl-methionine racemization namespace: biological_process alt_id: GO:0018087 alt_id: GO:0018369 def: "The racemization of peptidyl-methionine." [RESID:AA0193] subset: gosubset_prok xref: RESID:AA0193 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019124 name: peptidyl-isoleucine racemization namespace: biological_process alt_id: GO:0018088 alt_id: GO:0018370 def: "The racemization of peptidyl-isoleucine." [RESID:AA0192] subset: gosubset_prok xref: RESID:AA0192 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019125 name: peptidyl-phenylalanine racemization namespace: biological_process alt_id: GO:0018089 alt_id: GO:0018371 def: "The racemization of peptidyl-phenylalanine." [RESID:AA0194] subset: gosubset_prok xref: RESID:AA0194 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019126 name: peptidyl-serine racemization namespace: biological_process alt_id: GO:0018090 alt_id: GO:0018372 def: "The racemization of peptidyl-serine." [RESID:AA0195] subset: gosubset_prok xref: RESID:AA0195 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019128 name: peptidyl-tryptophan racemization namespace: biological_process alt_id: GO:0018092 alt_id: GO:0018374 def: "The racemization of peptidyl-tryptophan." [RESID:AA0198] subset: gosubset_prok xref: RESID:AA0198 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019129 name: peptidyl-leucine racemization namespace: biological_process alt_id: GO:0018093 alt_id: GO:0018375 def: "The racemization of peptidyl-leucine." [RESID:AA0197] subset: gosubset_prok xref: RESID:AA0197 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019131 name: tripeptidyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [EC:3.4.14.9] comment: This term was made obsolete because it represents a gene product. synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9] xref: EC:3.4.14.9 xref: MetaCyc:3.4.14.9-RXN is_obsolete: true replaced_by: GO:0008240 [Term] id: GO:0019132 name: C-terminal processing peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [EC:3.4.21.102] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "CtpA gene product (Synechocystis sp.)" RELATED [EC:3.4.21.102] synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102] synonym: "protease Re" RELATED [EC:3.4.21.102] synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102] synonym: "Tsp protease" NARROW [EC:3.4.21.102] xref: EC:3.4.21.102 xref: MetaCyc:3.4.21.102-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0019133 name: choline monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O." [EC:1.14.15.7] subset: gosubset_prok synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" EXACT [EC:1.14.15.7] xref: EC:1.14.15.7 xref: MetaCyc:RXN1F-357 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0019134 name: glucosamine-1-phosphate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+)." [EC:2.3.1.157, RHEA:13728] subset: gosubset_prok synonym: "acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] synonym: "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] xref: EC:2.3.1.157 xref: KEGG:R05332 xref: MetaCyc:2.3.1.157-RXN xref: RHEA:13728 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0019135 name: deoxyhypusine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29] synonym: "deoxyhypusine dioxygenase activity" EXACT [EC:1.14.99.29] synonym: "deoxyhypusine hydroxylase activity" EXACT [] synonym: "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.29] synonym: "DOHH activity" EXACT [EC:1.14.99.29] xref: EC:1.14.99.29 xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN xref: Reactome:7455 "deoxyhypusine monooxygenase activity" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0019136 name: deoxynucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145] subset: gosubset_prok synonym: "ATP:deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.145] synonym: "D. melanogaster deoxynucleoside kinase activity" EXACT [EC:2.7.1.145] synonym: "Dm-dNK" RELATED [EC:2.7.1.145] synonym: "ms-dNK" RELATED [EC:2.7.1.145] synonym: "Ms-dNK activity" RELATED [EC:2.7.1.145] synonym: "multifunctional deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145] xref: EC:2.7.1.145 xref: MetaCyc:2.7.1.145-RXN is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0019137 name: thioglucosidase activity namespace: molecular_function def: "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar." [EC:3.2.1.147] synonym: "myrosinase activity" EXACT [] synonym: "sinigrase activity" EXACT [] synonym: "sinigrinase activity" EXACT [] synonym: "thioglucoside glucohydrolase activity" EXACT [] xref: EC:3.2.1.147 xref: MetaCyc:RXN-9946 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0019139 name: cytokinin dehydrogenase activity namespace: molecular_function alt_id: GO:0046420 def: "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor." [EC:1.5.99.12] synonym: "6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] synonym: "cytokinin oxidase activity" RELATED [] synonym: "N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.12] synonym: "N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] xref: EC:1.5.99.12 xref: MetaCyc:1.5.99.12-RXN xref: MetaCyc:PWY-2841 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0019140 name: inositol 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate." [EC:2.7.1.64] synonym: "ATP:myo-inositol 1-phosphotransferase activity" EXACT [EC:2.7.1.64] synonym: "inositol 1-kinase activity" RELATED [EC:2.7.1.64] synonym: "inositol-1-kinase (phosphorylating)" EXACT [EC:2.7.1.64] synonym: "myo-inositol 1-kinase activity" RELATED [EC:2.7.1.64] synonym: "myo-inositol 3-kinase activity" EXACT [] synonym: "myoinositol kinase activity" BROAD [EC:2.7.1.64] xref: EC:2.7.1.64 xref: MetaCyc:MYO-INOSITOL-1-KINASE-RXN is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0019141 name: 2-dehydropantolactone reductase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.214] synonym: "(R)-pantolactone:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.214] synonym: "2-dehydropantoyl-lactone reductase (B-specific) activity" EXACT [] synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.214] synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] xref: EC:1.1.1.214 xref: MetaCyc:DEHYDROPANTLACRED-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019142 name: 2-hydroxyglutarate synthase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)." [EC:2.3.3.11, RHEA:19188] comment: Note that this function was formerly EC:4.1.3.9. synonym: "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity" EXACT [EC:2.3.3.11] synonym: "2-hydroxyglutaratic synthetase activity" EXACT [EC:2.3.3.11] synonym: "2-hydroxyglutaric synthetase activity" EXACT [EC:2.3.3.11] synonym: "alpha-hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] synonym: "hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] synonym: "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)" EXACT [EC:2.3.3.11] xref: EC:2.3.3.11 xref: KEGG:R00932 xref: MetaCyc:HYDGLUTSYN-RXN xref: RHEA:19188 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0019143 name: 3-deoxy-manno-octulosonate-8-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45, RHEA:11503] subset: gosubset_prok synonym: "3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity" EXACT [EC:3.1.3.45] xref: EC:3.1.3.45 xref: KEGG:R03350 xref: MetaCyc:KDO-8PPHOSPHAT-RXN xref: RHEA:11503 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019144 name: ADP-sugar diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate." [EC:3.6.1.21] subset: gosubset_prok synonym: "adenosine diphosphosugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "ADP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "ADP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.21] synonym: "ADPsugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "nucleoside diphosphate-sugar hydrolase activity" BROAD [GOC:vw] xref: EC:3.6.1.21 xref: MetaCyc:ADPSUGPPHOSPHAT-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0019145 name: aminobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.2.1.19] subset: gosubset_prok synonym: "4-aminobutanal dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "4-aminobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.19] synonym: "4-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "ABAL dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "gamma-aminobutyraldehyde dehydroganase activity" EXACT [EC:1.2.1.19] xref: EC:1.2.1.19 xref: MetaCyc:AMINOBUTDEHYDROG-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0019146 name: arabinose-5-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+)." [EC:5.3.1.13, RHEA:23107] subset: gosubset_prok synonym: "arabinose phosphate isomerase activity" EXACT [EC:5.3.1.13] synonym: "D-arabinose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.13] synonym: "D-arabinose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.13] synonym: "phosphoarabinoisomerase activity" EXACT [EC:5.3.1.13] xref: EC:5.3.1.13 xref: KEGG:R01530 xref: MetaCyc:DARAB5PISOM-RXN xref: RHEA:23107 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0019147 name: (R)-aminopropanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH." [EC:1.1.1.75, RHEA:16520] synonym: "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "1-aminopropan-2-ol-dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "1-aminopropan-2-ol-NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "L-aminopropanol dehydrogenase activity" EXACT [] xref: EC:1.1.1.75 xref: KEGG:R03759 xref: MetaCyc:AMINOPROPDEHYDROG-RXN xref: RHEA:16520 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019148 name: D-cysteine desulfhydrase activity namespace: molecular_function def: "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15] subset: gosubset_prok synonym: "D-cysteine lyase activity" EXACT [EC:4.4.1.15] synonym: "D-cysteine sulfide-lyase (deaminating)" EXACT [EC:4.4.1.15] synonym: "D-cysteine sulfide-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.15] xref: EC:4.4.1.15 xref: MetaCyc:DCYSDESULF-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0019149 name: 3-chloro-D-alanine dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3." [EC:4.5.1.2] synonym: "3-chloro-D-alanine chloride-lyase (deaminating)" EXACT [EC:4.5.1.2] synonym: "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.5.1.2] synonym: "beta-chloro-D-alanine dehydrochlorinase activity" EXACT [EC:4.5.1.2] xref: EC:4.5.1.2 xref: MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0019150 name: D-ribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate." [EC:2.7.1.47] subset: gosubset_prok synonym: "ATP:D-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.47] synonym: "D-ribulokinase (phosphorylating)" EXACT [EC:2.7.1.47] xref: EC:2.7.1.47 xref: MetaCyc:D-RIBULOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0019151 name: galactose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+." [EC:1.1.1.48] subset: gosubset_prok synonym: "beta-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] synonym: "D-galactose 1-dehydrogenase activity" EXACT [] synonym: "D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] synonym: "D-galactose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.48] synonym: "NAD-dependent D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] xref: EC:1.1.1.48 xref: MetaCyc:GALACTODEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019152 name: acetoin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+." [MetaCyc:ACETOINDEHYDROG-RXN] subset: gosubset_prok synonym: "diacetyl reductase activity" EXACT [EC:1.1.1.5] xref: EC:1.1.1.- xref: KEGG:R02343 xref: MetaCyc:ACETOINDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019153 name: protein-disulfide reductase (glutathione) activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol." [EC:1.8.4.2] subset: gosubset_prok synonym: "glutaredoxin reductase" RELATED [] synonym: "glutathione--insulin transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "glutathione-insulin transhydrogenase activity" EXACT [] synonym: "glutathione-protein disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "glutathione:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "GSH-insulin transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "insulin reductase activity" EXACT [EC:1.8.4.2] synonym: "protein disulfide reductase (glutathione)" EXACT [EC:1.8.4.2] synonym: "protein disulfide transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "protein-disulfide interchange enzyme" RELATED [EC:1.8.4.2] synonym: "protein-disulfide isomerase/oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "protein-disulphide reductase (glutathione) activity" EXACT [] synonym: "reductase, protein disulfide (glutathione)" EXACT [EC:1.8.4.2] synonym: "thiol-protein disulphide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "thiol:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] xref: EC:1.8.4.2 xref: MetaCyc:PRODISULFREDUCT-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0019154 name: glycolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate." [EC:1.1.99.14, RHEA:21267] synonym: "glycolate oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolic acid dehydrogenase activity" EXACT [EC:1.1.99.14] xref: EC:1.1.99.14 xref: KEGG:R00476 xref: MetaCyc:GLYCOLATEDEHYDRO-RXN xref: RHEA:21267 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0019155 name: 3-(imidazol-5-yl)lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+." [EC:1.1.1.111] synonym: "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.111] synonym: "imidazol-5-yl lactate dehydrogenase activity" EXACT [EC:1.1.1.111] xref: EC:1.1.1.111 xref: MetaCyc:IMILACTDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019156 name: isoamylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins." [EC:3.2.1.68] subset: gosubset_prok synonym: "debranching enzyme activity" BROAD [EC:3.2.1.68] synonym: "glycogen alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.68] xref: EC:3.2.1.68 xref: MetaCyc:3.2.1.68-RXN is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0019157 name: malate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + O(2) = H(2)O(2) + oxaloacetate." [EC:1.1.3.3, RHEA:10515] synonym: "(S)-malate:oxygen oxidoreductase activity" EXACT [EC:1.1.3.3] synonym: "FAD-dependent malate oxidase activity" EXACT [EC:1.1.3.3] synonym: "malic dehydrogenase II" RELATED [EC:1.1.3.3] synonym: "malic oxidase activity" EXACT [EC:1.1.3.3] xref: EC:1.1.3.3 xref: KEGG:R00360 xref: MetaCyc:MALOX-RXN xref: RHEA:10515 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0019158 name: mannokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7] subset: gosubset_prok synonym: "ATP:D-mannose 6-phosphotransferase activity" EXACT [EC:2.7.1.7] synonym: "D-fructose (D-mannose) kinase activity" EXACT [EC:2.7.1.7] synonym: "mannokinase (phosphorylating)" EXACT [EC:2.7.1.7] xref: EC:2.7.1.7 xref: MetaCyc:MANNKIN-RXN is_a: GO:0004396 ! hexokinase activity [Term] id: GO:0019159 name: nicotinamide-nucleotide amidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3." [EC:3.5.1.42] synonym: "nicotinamide mononucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] synonym: "nicotinamide mononucleotide deamidase activity" EXACT [EC:3.5.1.42] synonym: "nicotinamide-D-ribonucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] synonym: "NMN amidohydrolase" NARROW [] synonym: "NMN deamidase activity" EXACT [EC:3.5.1.42] xref: EC:3.5.1.42 xref: MetaCyc:NMNAMIDOHYDRO-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0019160 name: NMN nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + nicotinamide mononucleotide = D-ribose 5-phosphate + H(+) + nicotinamide." [EC:3.2.2.14, RHEA:23143] synonym: "nicotinamide mononucleotidase activity" EXACT [EC:3.2.2.14] synonym: "nicotinamide mononucleotide nucleosidase activity" EXACT [EC:3.2.2.14] synonym: "nicotinamide-nucleotide phosphoribohydrolase activity" EXACT [EC:3.2.2.14] synonym: "NMN glycohydrolase activity" EXACT [EC:3.2.2.14] synonym: "NMNase activity" EXACT [EC:3.2.2.14] synonym: "NMNGhase activity" EXACT [EC:3.2.2.14] xref: EC:3.2.2.14 xref: KEGG:R01270 xref: MetaCyc:NMNNUCLEOSID-RXN xref: RHEA:23143 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0019161 name: diamine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate." [EC:2.6.1.29] synonym: "amine transaminase activity" EXACT [EC:2.6.1.29] synonym: "amine-ketoacid transaminase activity" EXACT [EC:2.6.1.29] synonym: "diamine aminotransferase activity" EXACT [] synonym: "diamine-ketoglutaric transaminase activity" EXACT [EC:2.6.1.29] synonym: "diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.29] xref: EC:2.6.1.29 xref: MetaCyc:DIAMTRANSAM-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019162 name: pyridoxamine-oxaloacetate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal." [EC:2.6.1.31, RHEA:10847] synonym: "pyridoxamine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] synonym: "pyridoxamine-oxaloacetate aminotransferase activity" EXACT [] synonym: "pyridoxamine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] xref: EC:2.6.1.31 xref: KEGG:R01713 xref: MetaCyc:PYROXALTRANSAM-RXN xref: RHEA:10847 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019163 name: pyridoxamine-phosphate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate." [EC:2.6.1.54] synonym: "pyridoxamine 5'-phosphate transaminase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine phosphate aminotransferase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)" EXACT [EC:2.6.1.54] synonym: "pyridoxamine-phosphate aminotransferase activity" EXACT [] xref: EC:2.6.1.54 xref: MetaCyc:PYRDAMPTRANS-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019164 name: pyruvate synthase activity namespace: molecular_function alt_id: GO:0018696 def: "Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+." [KEGG:R01196] subset: gosubset_prok synonym: "pyruvate oxidoreductase activity" EXACT [EC:1.2.7.1] synonym: "pyruvate synthetase activity" EXACT [EC:1.2.7.1] synonym: "pyruvate-ferredoxin reductase activity" EXACT [] synonym: "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.7.1] synonym: "pyruvate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] synonym: "pyruvic-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] xref: EC:1.2.7.1 xref: KEGG:R01196 xref: MetaCyc:PYRUFLAVREDUCT-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0019165 name: thiamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine = ADP + 2 H(+) + thiamine phosphate." [EC:2.7.1.89, RHEA:12015] synonym: "ATP:thiamin phosphotransferase activity" EXACT [EC:2.7.1.89] synonym: "ATP:thiamine phosphotransferase activity" EXACT [EC:2.7.1.89] synonym: "thiamin kinase (phosphorylating)" EXACT [EC:2.7.1.89] synonym: "thiamin kinase activity" EXACT [EC:2.7.1.89] synonym: "thiamin phosphokinase activity" EXACT [EC:2.7.1.89] xref: EC:2.7.1.89 xref: KEGG:R02134 xref: MetaCyc:THIKIN-RXN xref: RHEA:12015 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0019166 name: trans-2-enoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38] synonym: "acyl-CoA:NADP+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.38] synonym: "NADPH-dependent trans-2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.38] synonym: "reductase, trans-enoyl coenzyme A" EXACT [EC:1.3.1.38] xref: EC:1.3.1.38 xref: MetaCyc:TRANSENOYLCOARED-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0019168 name: 2-octaprenylphenol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN] xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0019170 name: methylglyoxal reductase (NADH-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [EC:1.1.1.78] synonym: "(R)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.78] synonym: "D-lactaldehyde dehydrogenase activity" EXACT [] synonym: "methylglyoxal reductase activity" EXACT [] xref: EC:1.1.1.78 xref: MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019171 name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein]." [MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN] subset: gosubset_prok synonym: "3-hydroxyacyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxyacyl-ACP dehydratase activity" EXACT [] xref: EC:4.2.1.59 xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0019172 name: glyoxalase III activity namespace: molecular_function def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [MetaCyc:GLYOXIII-RXN] comment: Note that this term was reinstated from obsolete. xref: MetaCyc:GLYOXIII-RXN is_a: GO:0003824 ! catalytic activity [Term] id: GO:0019174 name: tetrahydrothiophene 1-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor." [MetaCyc:THTOREDUCT-RXN] xref: MetaCyc:THTOREDUCT-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0019176 name: dihydroneopterin monophosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN] synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT [] xref: EC:3.6.1.- xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0019177 name: dihydroneopterin triphosphate pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN] xref: EC:3.6.1.- xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0019178 name: NADP phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate." [MetaCyc:NADPPHOSPHAT-RXN] xref: EC:3.1.3.- xref: MetaCyc:NADPPHOSPHAT-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019179 name: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate." [EC:2.6.1.33] synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity" EXACT [] synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "TDP-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "TDP-4-oxo-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity" EXACT [EC:2.6.1.33] xref: EC:2.6.1.33 xref: MetaCyc:2.6.1.33-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019180 name: dTDP-4-amino-4,6-dideoxygalactose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose." [EC:2.6.1.59, RHEA:10371] synonym: "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.59] synonym: "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] synonym: "dTDP-fucosamine aminotransferase activity" EXACT [] synonym: "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.59] synonym: "thymidine diphosphoaminodideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] xref: EC:2.6.1.59 xref: KEGG:R04438 xref: MetaCyc:2.6.1.59-RXN xref: RHEA:10371 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019181 name: halohydrin hydrogen-halide-lyase activity namespace: molecular_function def: "Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide." [PMID:8017917] xref: EC:4.5.1.- is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0019182 name: histamine-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005254 ! chloride channel activity is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0019183 name: histamine-gated chloride channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034707 ! chloride channel complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0019184 name: nonribosomal peptide biosynthetic process namespace: biological_process def: "The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "non-ribosomal peptide biosynthesis" EXACT [] synonym: "non-ribosomal peptide biosynthetic process" EXACT [] synonym: "non-ribosomal peptide formation" EXACT [] synonym: "non-ribosomal peptide synthesis" EXACT [] synonym: "nonribosomal peptide anabolism" EXACT [] synonym: "nonribosomal peptide biosynthesis" EXACT [] synonym: "nonribosomal peptide formation" EXACT [] synonym: "nonribosomal peptide synthesis" EXACT [] synonym: "nonribosomal peptide synthetase" RELATED [] is_a: GO:0043043 ! peptide biosynthetic process [Term] id: GO:0019185 name: snRNA-activating protein complex namespace: cellular_component def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788] synonym: "SNAPc" EXACT [] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0019186 name: acyl-CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule." [GOC:mah] xref: EC:2.3.1.- is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0019187 name: beta-1,4-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming a beta-1,4-linkage." [GOC:mcc, PMID:8166646] xref: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0019191 name: cellobiose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019190 def: "Catalysis of the transfer of cellobiose from one side of the membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "cellobiose permease activity" EXACT [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0019194 name: sorbose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019193 def: "Catalysis of the transfer of sorbose from one side of the membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sorbose porter activity" EXACT [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0019196 name: galactosamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0019195 def: "Catalysis of the transfer of galactosamine from one side of the membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] synonym: "galactosamine porter activity" EXACT [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0019197 name: phosphoenolpyruvate-dependent sugar phosphotransferase complex namespace: cellular_component def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0019198 name: transmembrane receptor protein phosphatase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate." [GOC:hjd] xref: EC:3.1.3.- is_a: GO:0004721 ! phosphoprotein phosphatase activity is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0019199 name: transmembrane receptor protein kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:mah] subset: gosubset_prok xref: EC:2.7.11.- is_a: GO:0004672 ! protein kinase activity is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0019200 name: carbohydrate kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl] subset: gosubset_prok is_a: GO:0016301 ! kinase activity [Term] id: GO:0019201 name: nucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: GO:0019202 name: amino acid kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl] subset: gosubset_prok is_a: GO:0016301 ! kinase activity [Term] id: GO:0019203 name: carbohydrate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah] subset: gosubset_prok is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019204 name: nucleotide phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah] synonym: "polynucleotide phosphatase activity" EXACT [GOC:mah] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019205 name: nucleobase, nucleoside, nucleotide kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] subset: gosubset_prok is_a: GO:0016301 ! kinase activity [Term] id: GO:0019206 name: nucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [GOC:ai] subset: gosubset_prok xref: Reactome:6991 "nucleoside kinase activity" is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: GO:0019207 name: kinase regulator activity namespace: molecular_function def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] subset: gosubset_prok is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0019208 name: phosphatase regulator activity namespace: molecular_function def: "Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0019209 name: kinase activator activity namespace: molecular_function def: "Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] subset: gosubset_prok is_a: GO:0008047 ! enzyme activator activity is_a: GO:0019207 ! kinase regulator activity [Term] id: GO:0019210 name: kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] subset: gosubset_prok is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0019207 ! kinase regulator activity [Term] id: GO:0019211 name: phosphatase activator activity namespace: molecular_function def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0019208 ! phosphatase regulator activity [Term] id: GO:0019212 name: phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0019208 ! phosphatase regulator activity [Term] id: GO:0019213 name: deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0019214 name: surfactant activity namespace: molecular_function def: "OBSOLETE. The action of reducing the surface tension of a liquid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents involvement in a process. is_obsolete: true consider: GO:0050828 [Term] id: GO:0019215 name: intermediate filament binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0019216 name: regulation of lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of lipid metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0019217 name: regulation of fatty acid metabolic process namespace: biological_process alt_id: GO:0006632 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of fatty acid metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process relationship: regulates GO:0006631 ! fatty acid metabolic process [Term] id: GO:0019218 name: regulation of steroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of steroid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process relationship: regulates GO:0008202 ! steroid metabolic process [Term] id: GO:0019219 name: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Term] id: GO:0019220 name: regulation of phosphate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of phosphate metabolism" EXACT [] is_a: GO:0051174 ! regulation of phosphorus metabolic process relationship: regulates GO:0006796 ! phosphate metabolic process [Term] id: GO:0019221 name: cytokine-mediated signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor." [GOC:mah] synonym: "cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "cytokine mediated signalling pathway" EXACT [] xref: Reactome:913531 "Interferon Signaling" is_a: GO:0007166 ! cell surface receptor linked signaling pathway is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of metabolism" EXACT [] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0008152 ! metabolic process [Term] id: GO:0019226 name: transmission of nerve impulse namespace: biological_process def: "The neurological system process in which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation." [GOC:curators, ISBN:0815316194] synonym: "signal transmission along a neuron" EXACT [] is_a: GO:0035637 ! multicellular organismal signaling is_a: GO:0050877 ! neurological system process relationship: part_of GO:0007154 ! cell communication [Term] id: GO:0019227 name: neuronal action potential propagation namespace: biological_process def: "A neurological process that causes the sequential depolarization of a neuron's cell membrane along an axon." [GOC:isa_complete] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0019226 ! transmission of nerve impulse [Term] id: GO:0019228 name: regulation of action potential in neuron namespace: biological_process def: "The process that modulates the membrane potential involved in the propagation of a signal in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] is_a: GO:0001508 ! regulation of action potential relationship: part_of GO:0019226 ! transmission of nerve impulse [Term] id: GO:0019229 name: regulation of vasoconstriction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl] is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0042310 ! vasoconstriction [Term] id: GO:0019230 name: proprioception namespace: biological_process def: "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [http://www.onelook.com/, ISBN:072168677X] xref: Wikipedia:Proprioception is_a: GO:0007600 ! sensory perception relationship: part_of GO:0050884 ! neuromuscular process controlling posture [Term] id: GO:0019231 name: perception of static position namespace: biological_process def: "The perception of the orientation of different parts of the body with respect to one another." [ISBN:072168677X] is_a: GO:0019230 ! proprioception [Term] id: GO:0019232 name: perception of rate of movement namespace: biological_process def: "The series of events by which an organism senses the speed and direction of movement of the body and its parts." [GOC:mah] synonym: "kinesthesia" EXACT [] is_a: GO:0019230 ! proprioception [Term] id: GO:0019233 name: sensory perception of pain namespace: biological_process def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [http://www.onelook.com/] synonym: "nociception" EXACT [] synonym: "perception of physiological pain" NARROW [] xref: Wikipedia:Nociception is_a: GO:0007600 ! sensory perception [Term] id: GO:0019234 name: sensory perception of fast pain namespace: biological_process def: "The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds." [http://www.spine-health.com/] is_a: GO:0019233 ! sensory perception of pain [Term] id: GO:0019235 name: sensory perception of slow pain namespace: biological_process def: "The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction." [http://www.people.vcu.edu/~mikuleck/ssspain/, http://www.spine-health.com/] is_a: GO:0019233 ! sensory perception of pain [Term] id: GO:0019236 name: response to pheromone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] subset: gosubset_prok synonym: "pheromone response" EXACT [] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0019237 name: centromeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis." [GOC:jl, SO:0000577] synonym: "centromere binding" EXACT [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0019238 name: cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah] subset: gosubset_prok is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0019239 name: deaminase activity namespace: molecular_function def: "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0019240 name: citrulline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "citrulline anabolism" EXACT [] synonym: "citrulline biosynthesis" EXACT [] synonym: "citrulline formation" EXACT [] synonym: "citrulline synthesis" EXACT [] xref: MetaCyc:CITRULBIO-PWY is_a: GO:0000052 ! citrulline metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0019241 name: citrulline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "citrulline breakdown" EXACT [] synonym: "citrulline catabolism" EXACT [] synonym: "citrulline degradation" EXACT [] xref: MetaCyc:CITRULLINE-DEG-PWY is_a: GO:0000052 ! citrulline metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0019242 name: methylglyoxal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] subset: gosubset_prok synonym: "methylglyoxal anabolism" EXACT [] synonym: "methylglyoxal biosynthesis" EXACT [] synonym: "methylglyoxal formation" EXACT [] synonym: "methylglyoxal synthesis" EXACT [] is_a: GO:0009438 ! methylglyoxal metabolic process is_a: GO:0046184 ! aldehyde biosynthetic process [Term] id: GO:0019243 name: methylglyoxal catabolic process to D-lactate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai] subset: gosubset_prok synonym: "D-lactate biosynthesis from methylglyoxal" EXACT [] synonym: "D-lactate biosynthetic process from methylglyoxal" EXACT [] synonym: "glyoxalase system" RELATED [] synonym: "methylglyoxal breakdown to D-lactate" EXACT [] synonym: "methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione" EXACT [] synonym: "methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione" EXACT [] synonym: "methylglyoxal degradation to D-lactate" EXACT [] synonym: "methylglyoxal detoxification" RELATED [] xref: MetaCyc:PWY-901 is_a: GO:0006089 ! lactate metabolic process is_a: GO:0051596 ! methylglyoxal catabolic process [Term] id: GO:0019244 name: lactate biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate." [GOC:go_curators] subset: gosubset_prok synonym: "lactate anabolism from pyruvate" EXACT [] synonym: "lactate formation from pyruvate" EXACT [] synonym: "lactate synthesis from pyruvate" EXACT [] is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0019249 ! lactate biosynthetic process [Term] id: GO:0019245 name: D(-)-lactate biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate." [GOC:go_curators] subset: gosubset_prok synonym: "D(-)-lactate anabolism from pyruvate" EXACT [] synonym: "D(-)-lactate formation from pyruvate" EXACT [] synonym: "D(-)-lactate synthesis from pyruvate" EXACT [] is_a: GO:0019244 ! lactate biosynthetic process from pyruvate [Term] id: GO:0019246 name: L(+)-lactate biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L(+)lactate from other compounds, including pyruvate." [GOC:go_curators] subset: gosubset_prok synonym: "L(+)-lactate anabolism from pyruvate" EXACT [] synonym: "L(+)-lactate formation from pyruvate" EXACT [] synonym: "L(+)-lactate synthesis from pyruvate" EXACT [] is_a: GO:0019244 ! lactate biosynthetic process from pyruvate [Term] id: GO:0019247 name: lactate racemization namespace: biological_process def: "Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture." [GOC:curators, PMID:16166538] subset: gosubset_prok is_a: GO:0006089 ! lactate metabolic process [Term] id: GO:0019248 name: D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-lactate from other compounds, including methylglyoxal, via the intermediate (R)-lactaldehyde." [GOC:go_curators] subset: gosubset_prok synonym: "D-lactate anabolism from methylglyoxal via (R)-lactaldehyde" EXACT [] synonym: "D-lactate formation from methylglyoxal via (R)-lactaldehyde" EXACT [] synonym: "D-lactate synthesis from methylglyoxal via (R)-lactaldehyde" EXACT [] xref: MetaCyc:MGLDLCTANA-PWY is_a: GO:0019243 ! methylglyoxal catabolic process to D-lactate is_a: GO:0019249 ! lactate biosynthetic process [Term] id: GO:0019249 name: lactate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." [GOC:go_curators] subset: gosubset_prok synonym: "lactate anabolism" EXACT [] synonym: "lactate biosynthesis" EXACT [] synonym: "lactate formation" EXACT [] synonym: "lactate synthesis" EXACT [] is_a: GO:0006089 ! lactate metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0019250 name: aerobic cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen." [GOC:go_curators] subset: gosubset_prok synonym: "aerobic cobalamin anabolism" EXACT [] synonym: "aerobic cobalamin biosynthesis" EXACT [] synonym: "aerobic cobalamin formation" EXACT [] synonym: "aerobic cobalamin synthesis" EXACT [] synonym: "aerobic vitamin B12 biosynthesis" EXACT [] synonym: "aerobic vitamin B12 biosynthetic process" EXACT [] synonym: "cobalamin biosynthesis, aerobic" EXACT [] synonym: "cobalamin biosynthetic process, aerobic" EXACT [] synonym: "vitamin B12 biosynthesis, aerobic" EXACT [] synonym: "vitamin B12 biosynthetic process, aerobic" EXACT [] xref: MetaCyc:P381-PWY is_a: GO:0009236 ! cobalamin biosynthetic process [Term] id: GO:0019251 name: anaerobic cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen." [GOC:go_curators] subset: gosubset_prok synonym: "anaerobic cobalamin anabolism" EXACT [] synonym: "anaerobic cobalamin biosynthesis" EXACT [] synonym: "anaerobic cobalamin formation" EXACT [] synonym: "anaerobic cobalamin synthesis" EXACT [] synonym: "anaerobic vitamin B12 biosynthesis" EXACT [] synonym: "anaerobic vitamin B12 biosynthetic process" EXACT [] synonym: "cobalamin biosynthesis, anaerobic" EXACT [] synonym: "cobalamin biosynthetic process, anaerobic" EXACT [] synonym: "vitamin B12 biosynthesis, anaerobic" EXACT [] synonym: "vitamin B12 biosynthetic process, anaerobic" EXACT [] xref: MetaCyc:COBALSYN-PWY is_a: GO:0009236 ! cobalamin biosynthetic process [Term] id: GO:0019252 name: starch biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants." [GOC:ai] subset: gosubset_prok synonym: "starch anabolism" EXACT [] synonym: "starch biosynthesis" EXACT [] synonym: "starch formation" EXACT [] synonym: "starch synthesis" EXACT [] xref: MetaCyc:PWY-622 is_a: GO:0005982 ! starch metabolic process is_a: GO:0009250 ! glucan biosynthetic process [Term] id: GO:0019253 name: reductive pentose-phosphate cycle namespace: biological_process def: "The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate." [ISBN:0198547684] comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. synonym: "C3 photosynthesis" NARROW [] synonym: "Calvin cycle" NARROW [] xref: MetaCyc:CALVIN-PWY is_a: GO:0019685 ! photosynthesis, dark reaction relationship: part_of GO:0015977 ! carbon fixation [Term] id: GO:0019254 name: carnitine metabolic process, CoA-linked namespace: biological_process def: "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:go_curators] subset: gosubset_prok synonym: "carnitine metabolism, CoA-linked" EXACT [] xref: MetaCyc:CARNMET-PWY is_a: GO:0009437 ! carnitine metabolic process [Term] id: GO:0019255 name: glucose 1-phosphate metabolic process namespace: biological_process alt_id: GO:0006008 def: "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai] subset: gosubset_prok synonym: "glucose 1-phosphate metabolism" EXACT [] synonym: "glucose 1-phosphate utilization" RELATED [GOC:mah] xref: MetaCyc:GLUCOSE1PMETAB-PWY is_a: GO:0006006 ! glucose metabolic process [Term] id: GO:0019256 name: acrylonitrile catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [GOC:ai] subset: gosubset_prok synonym: "acrylonitrile breakdown" EXACT [] synonym: "acrylonitrile catabolism" EXACT [] synonym: "acrylonitrile degradation" EXACT [] xref: MetaCyc:P344-PWY is_a: GO:0018865 ! acrylonitrile metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0050899 ! nitrile catabolic process [Term] id: GO:0019257 name: 4-nitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor." [GOC:ai] subset: gosubset_prok synonym: "4-nitrotoluene metabolism" EXACT [] synonym: "4NT metabolic process" EXACT [] synonym: "4NT metabolism" EXACT [] is_a: GO:0019326 ! nitrotoluene metabolic process [Term] id: GO:0019258 name: 4-nitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai] subset: gosubset_prok synonym: "4-nitrotoluene breakdown" EXACT [] synonym: "4-nitrotoluene catabolism" EXACT [] synonym: "4-nitrotoluene degradation" EXACT [] synonym: "4NT catabolic process" EXACT [] synonym: "4NT catabolism" EXACT [] xref: MetaCyc:P421-PWY is_a: GO:0019257 ! 4-nitrotoluene metabolic process is_a: GO:0046263 ! nitrotoluene catabolic process [Term] id: GO:0019260 name: 1,2-dichloroethane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:go_curators] subset: gosubset_prok synonym: "1,2-dichloroethane breakdown" EXACT [] synonym: "1,2-dichloroethane catabolism" EXACT [] synonym: "1,2-dichloroethane degradation" EXACT [] xref: MetaCyc:12DICHLORETHDEG-PWY is_a: GO:0018899 ! 1,2-dichloroethane metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process [Term] id: GO:0019261 name: 1,4-dichlorobenzene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring." [GOC:ai] subset: gosubset_prok synonym: "1,4-dichlorobenzene breakdown" EXACT [] synonym: "1,4-dichlorobenzene catabolism" EXACT [] synonym: "1,4-dichlorobenzene degradation" EXACT [] xref: MetaCyc:14DICHLORBENZDEG-PWY is_a: GO:0018912 ! 1,4-dichlorobenzene metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process [Term] id: GO:0019262 name: N-acetylneuraminate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylneuraminate breakdown" EXACT [] synonym: "N-acetylneuraminate catabolism" EXACT [] synonym: "N-acetylneuraminate degradation" EXACT [] xref: MetaCyc:P441-PWY is_a: GO:0006054 ! N-acetylneuraminate metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0019263 name: adamantanone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] subset: gosubset_prok synonym: "adamantanone breakdown" EXACT [] synonym: "adamantanone catabolism" EXACT [] synonym: "adamantanone degradation" EXACT [] xref: MetaCyc:P481-PWY is_a: GO:0018866 ! adamantanone metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042182 ! ketone catabolic process [Term] id: GO:0019264 name: glycine biosynthetic process from serine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators] subset: gosubset_prok synonym: "glycine anabolism from serine" EXACT [] synonym: "glycine formation from serine" EXACT [] synonym: "glycine synthesis from serine" EXACT [] xref: MetaCyc:GLYSYN-PWY is_a: GO:0006545 ! glycine biosynthetic process is_a: GO:0006563 ! L-serine metabolic process [Term] id: GO:0019265 name: glycine biosynthetic process, by transamination of glyoxylate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate." [GOC:go_curators] subset: gosubset_prok synonym: "glycine anabolism, by transamination of glyoxylate" EXACT [] synonym: "glycine formation, by transamination of glyoxylate" EXACT [] synonym: "glycine synthesis, by transamination of glyoxylate" EXACT [] is_a: GO:0006545 ! glycine biosynthetic process [Term] id: GO:0019266 name: asparagine biosynthetic process from oxaloacetate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate." [GOC:go_curators] subset: gosubset_prok synonym: "asparagine anabolism from oxaloacetate" EXACT [] synonym: "asparagine formation from oxaloacetate" EXACT [] synonym: "asparagine synthesis from oxaloacetate" EXACT [] xref: MetaCyc:ASPARAGINE-BIOSYNTHESIS is_a: GO:0006107 ! oxaloacetate metabolic process is_a: GO:0006529 ! asparagine biosynthetic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0019267 name: asparagine biosynthetic process from cysteine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine." [GOC:go_curators] subset: gosubset_prok synonym: "asparagine anabolism from cysteine" EXACT [] synonym: "asparagine formation from cysteine" EXACT [] synonym: "asparagine synthesis from cysteine" EXACT [] xref: MetaCyc:ASPSYNII-PWY is_a: GO:0006529 ! asparagine biosynthetic process is_a: GO:0006534 ! cysteine metabolic process [Term] id: GO:0019268 name: glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function. synonym: "glutamate anabolism, using glutamate dehydrogenase (NAD(P)+)" EXACT [] synonym: "glutamate formation, using glutamate dehydrogenase (NAD(P)+)" EXACT [] synonym: "glutamate synthesis, using glutamate dehydrogenase (NAD(P)+)" EXACT [] is_obsolete: true replaced_by: GO:0004353 replaced_by: GO:0006537 [Term] id: GO:0019269 name: glutamate biosynthetic process, using glutamate synthase (NADPH) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH)." [GOC:go_curators] comment: This term was made obsolete because it refers to a molecular function. synonym: "glutamate anabolism, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamate formation, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamate synthesis, using glutamate synthase (NADPH)" EXACT [] is_obsolete: true replaced_by: GO:0004355 replaced_by: GO:0006537 [Term] id: GO:0019270 name: aerobactin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] subset: gosubset_prok synonym: "aerobactin anabolism" EXACT [] synonym: "aerobactin biosynthesis" EXACT [] synonym: "aerobactin formation" EXACT [] synonym: "aerobactin synthesis" EXACT [] xref: MetaCyc:AEROBACTINSYN-PWY is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046442 ! aerobactin metabolic process [Term] id: GO:0019271 name: aerobactin transport namespace: biological_process def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0019272 name: L-alanine biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate." [GOC:go_curators] subset: gosubset_prok synonym: "L-alanine anabolism from pyruvate" EXACT [] synonym: "L-alanine formation from pyruvate" EXACT [] synonym: "L-alanine synthesis from pyruvate" EXACT [] xref: MetaCyc:ALANINE-SYN2-PWY xref: MetaCyc:ALANINE-VALINESYN-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0042852 ! L-alanine biosynthetic process [Term] id: GO:0019273 name: L-alanine biosynthetic process via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine." [GOC:go_curators] subset: gosubset_prok synonym: "L-alanine anabolism via ornithine" EXACT [] synonym: "L-alanine formation via ornithine" EXACT [] synonym: "L-alanine synthesis via ornithine" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0042852 ! L-alanine biosynthetic process [Term] id: GO:0019276 name: UDP-N-acetylgalactosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-N-acetylgalactosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0019277 name: UDP-N-acetylgalactosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-N-acetylgalactosamine anabolism" EXACT [] synonym: "UDP-N-acetylgalactosamine biosynthesis" EXACT [] synonym: "UDP-N-acetylgalactosamine formation" EXACT [] synonym: "UDP-N-acetylgalactosamine synthesis" EXACT [] xref: MetaCyc:UDPNACETYLGALSYN-PWY is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0019278 name: UDP-N-acetylgalactosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-N-acetylgalactosamine breakdown" EXACT [] synonym: "UDP-N-acetylgalactosamine catabolism" EXACT [] synonym: "UDP-N-acetylgalactosamine degradation" EXACT [] is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0019279 name: L-methionine biosynthetic process from L-homoserine via cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine." [GOC:go_curators] subset: gosubset_prok synonym: "L-methionine anabolism from L-homoserine via cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from L-homoserine via cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from L-homoserine via cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from L-homoserine via cystathionine" EXACT [GOC:mah] xref: MetaCyc:HOMOSER-METSYN-PWY is_a: GO:0009092 ! homoserine metabolic process is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process [Term] id: GO:0019280 name: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine." [GOC:go_curators] subset: gosubset_prok synonym: "L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] xref: MetaCyc:HSERMETANA-PWY is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine [Term] id: GO:0019281 name: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators] subset: gosubset_prok synonym: "L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] xref: MetaCyc:MET-SAM-PWY is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine [Term] id: GO:0019282 name: L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine namespace: biological_process def: "The direct chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-acetyl-L-homoserine." [GOC:go_curators] subset: gosubset_prok synonym: "L-methionine anabolism, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "L-methionine formation, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "L-methionine synthesis, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process [Term] id: GO:0019283 name: L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine." [GOC:go_curators] subset: gosubset_prok synonym: "L-methionine anabolism from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process [Term] id: GO:0019284 name: L-methionine biosynthetic process from S-adenosylmethionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including S-adenosylmethionine." [GOC:go_curators] subset: gosubset_prok synonym: "L-methionine anabolism from S-adenosylmethionine" EXACT [GOC:mah] synonym: "L-methionine biosynthesis from S-adenosyl methionine" EXACT [GOC:mah] synonym: "L-methionine biosynthetic process from S-adenosyl methionine" EXACT [GOC:mah] synonym: "L-methionine formation from S-adenosylmethionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from S-adenosylmethionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from S-adenosylmethionine" EXACT [GOC:mah] is_a: GO:0046500 ! S-adenosylmethionine metabolic process is_a: GO:0071267 ! L-methionine salvage relationship: part_of GO:0033353 ! S-adenosylmethionine cycle [Term] id: GO:0019285 name: glycine betaine biosynthetic process from choline namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline." [GOC:jl] subset: gosubset_prok synonym: "glycine betaine anabolism from choline" EXACT [] synonym: "glycine betaine formation from choline" EXACT [] synonym: "glycine betaine synthesis from choline" EXACT [] synonym: "N-trimethylglycine biosynthesis from choline" EXACT [] synonym: "N-trimethylglycine biosynthetic process from choline" EXACT [] xref: MetaCyc:BETSYN-PWY xref: MetaCyc:CHOLINE-BETAINE-ANA-PWY xref: MetaCyc:P542-PWY is_a: GO:0019695 ! choline metabolic process is_a: GO:0031456 ! glycine betaine biosynthetic process [Term] id: GO:0019286 name: glycine betaine biosynthetic process from glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine." [GOC:go_curators] subset: gosubset_prok synonym: "glycine betaine anabolism from glycine" EXACT [] synonym: "glycine betaine formation from glycine" EXACT [] synonym: "glycine betaine synthesis from glycine" EXACT [] synonym: "N-trimethylglycine biosynthesis from glycine" EXACT [] synonym: "N-trimethylglycine biosynthetic process from glycine" EXACT [] xref: MetaCyc:P541-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0031456 ! glycine betaine biosynthetic process [Term] id: GO:0019287 name: isopentenyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922] subset: gosubset_prok synonym: "Ac-MVA pathway" EXACT [PMID:14517367] synonym: "acetate-mevalonate pathway" EXACT [PMID:14517367] synonym: "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate formation, mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process [Term] id: GO:0019288 name: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:go_curators, MetaCyc:NONMEVIPP-PWY] subset: gosubset_prok synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthesis, mevalonate-independent" EXACT [] synonym: "isopentenyl diphosphate biosynthesis, non-mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process, non-mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway" EXACT [] synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway" EXACT [] synonym: "mevalonate-independent isopentenyl diphosphate biosynthesis" EXACT [] synonym: "mevalonate-independent isopentenyl diphosphate biosynthetic process" EXACT [] synonym: "non-MVA pathway" EXACT [] xref: MetaCyc:NONMEVIPP-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process [Term] id: GO:0019289 name: rhizobactin 1021 biosynthetic process namespace: biological_process alt_id: GO:0031193 alt_id: GO:0031194 def: "The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] subset: gosubset_prok synonym: "rhizobactin 1021 anabolism" EXACT [] synonym: "rhizobactin 1021 biosynthesis" EXACT [] synonym: "rhizobactin 1021 biosynthetic process, peptide formation" NARROW [] synonym: "rhizobactin 1021 biosynthetic process, peptide modification" NARROW [] synonym: "rhizobactin 1021 formation" EXACT [] synonym: "rhizobactin 1021 synthesis" EXACT [] xref: MetaCyc:PWY-761 is_a: GO:0019540 ! siderophore biosynthetic process from catechol is_a: GO:0046494 ! rhizobactin 1021 metabolic process [Term] id: GO:0019290 name: siderophore biosynthetic process namespace: biological_process alt_id: GO:0031178 alt_id: GO:0031180 def: "The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:go_curators] comment: See also the biological process term 'nonribosomal peptide biosynthetic process ; GO:0019184'. subset: gosubset_prok synonym: "siderochrome biosynthesis" NARROW [] synonym: "siderochrome biosynthetic process" NARROW [] synonym: "siderophore anabolism" EXACT [] synonym: "siderophore biosynthesis" EXACT [] synonym: "siderophore biosynthetic process, peptide formation" NARROW [] synonym: "siderophore biosynthetic process, peptide modification" NARROW [] synonym: "siderophore formation" EXACT [] synonym: "siderophore synthesis" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0019292 name: tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate." [GOC:go_curators] subset: gosubset_prok synonym: "tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate" EXACT [] synonym: "tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate" EXACT [] synonym: "tyrosine formation from chorismate via 4-hydroxyphenylpyruvate" EXACT [] synonym: "tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate" EXACT [] xref: MetaCyc:TYRSYN is_a: GO:0006571 ! tyrosine biosynthetic process [Term] id: GO:0019293 name: tyrosine biosynthetic process, by oxidation of phenylalanine namespace: biological_process alt_id: GO:0019291 def: "The chemical reactions and pathways resulting in the formation of tyrosine by the oxidation of phenylalanine." [GOC:go_curators] subset: gosubset_prok synonym: "tyrosine anabolism from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine anabolism, by oxidation of phenylalanine" EXACT [] synonym: "tyrosine biosynthetic process from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine formation from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine formation, by oxidation of phenylalanine" EXACT [] synonym: "tyrosine synthesis from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine synthesis, by oxidation of phenylalanine" EXACT [] is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0006571 ! tyrosine biosynthetic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019294 name: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [CHEBI:32817, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "KDO biosynthesis" EXACT [] synonym: "KDO biosynthetic process" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid formation" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT [] synonym: "ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732] xref: MetaCyc:KDOSYN-PWY is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046400 ! keto-3-deoxy-D-manno-octulosonic acid metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0019295 name: coenzyme M biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [ISBN:0198547684] subset: gosubset_prok synonym: "coenzyme M anabolism" EXACT [] synonym: "coenzyme M biosynthesis" EXACT [] synonym: "coenzyme M formation" EXACT [] synonym: "coenzyme M synthesis" EXACT [] xref: MetaCyc:P261-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019296 ! coenzyme M metabolic process [Term] id: GO:0019296 name: coenzyme M metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] subset: gosubset_prok synonym: "coenzyme M metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0019297 name: coenzyme B metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] subset: gosubset_prok synonym: "coenzyme B metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0019298 name: coenzyme B biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [PMID:10940051] subset: gosubset_prok synonym: "coenzyme B anabolism" EXACT [] synonym: "coenzyme B biosynthesis" EXACT [] synonym: "coenzyme B formation" EXACT [] synonym: "coenzyme B synthesis" EXACT [] xref: MetaCyc:P241-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019297 ! coenzyme B metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0019299 name: rhamnose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "rhamnose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0019300 name: rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "rhamnose anabolism" EXACT [] synonym: "rhamnose biosynthesis" EXACT [] synonym: "rhamnose formation" EXACT [] synonym: "rhamnose synthesis" EXACT [] is_a: GO:0019299 ! rhamnose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0019301 name: rhamnose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "rhamnose breakdown" EXACT [] synonym: "rhamnose catabolism" EXACT [] synonym: "rhamnose degradation" EXACT [] xref: MetaCyc:RHAMCAT-PWY is_a: GO:0019299 ! rhamnose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019302 name: D-ribose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-ribose anabolism" EXACT [] synonym: "D-ribose biosynthesis" EXACT [] synonym: "D-ribose formation" EXACT [] synonym: "D-ribose synthesis" EXACT [] is_a: GO:0006014 ! D-ribose metabolic process is_a: GO:0019322 ! pentose biosynthetic process [Term] id: GO:0019303 name: D-ribose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-ribose breakdown" EXACT [] synonym: "D-ribose catabolism" EXACT [] synonym: "D-ribose degradation" EXACT [] xref: MetaCyc:RIBOKIN-PWY is_a: GO:0006014 ! D-ribose metabolic process is_a: GO:0019323 ! pentose catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0019304 name: anaerobic rhamnose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic rhamnose breakdown" EXACT [] synonym: "anaerobic rhamnose catabolism" EXACT [] synonym: "anaerobic rhamnose degradation" EXACT [] is_a: GO:0019301 ! rhamnose catabolic process [Term] id: GO:0019305 name: dTDP-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "dTDP-rhamnose anabolism" EXACT [] synonym: "dTDP-rhamnose biosynthesis" EXACT [] synonym: "dTDP-rhamnose formation" EXACT [] synonym: "dTDP-rhamnose synthesis" EXACT [] xref: MetaCyc:DTDPRHAMSYN-PWY xref: MetaCyc:PWY-3221 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046383 ! dTDP-rhamnose metabolic process [Term] id: GO:0019306 name: GDP-D-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "GDP-D-rhamnose anabolism" EXACT [] synonym: "GDP-D-rhamnose biosynthesis" EXACT [] synonym: "GDP-D-rhamnose formation" EXACT [] synonym: "GDP-D-rhamnose synthesis" EXACT [] xref: MetaCyc:GDPRHAMSYN-PWY is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046382 ! GDP-D-rhamnose metabolic process [Term] id: GO:0019307 name: mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] subset: gosubset_prok synonym: "mannose anabolism" EXACT [] synonym: "mannose biosynthesis" EXACT [] synonym: "mannose formation" EXACT [] synonym: "mannose synthesis" EXACT [] is_a: GO:0006013 ! mannose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0019308 name: dTDP-mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "dTDP-mannose anabolism" EXACT [] synonym: "dTDP-mannose biosynthesis" EXACT [] synonym: "dTDP-mannose formation" EXACT [] synonym: "dTDP-mannose synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0019307 ! mannose biosynthetic process is_a: GO:0046371 ! dTDP-mannose metabolic process [Term] id: GO:0019309 name: mannose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] subset: gosubset_prok synonym: "mannose breakdown" EXACT [] synonym: "mannose catabolism" EXACT [] synonym: "mannose degradation" EXACT [] xref: MetaCyc:MANNCAT-PWY is_a: GO:0006013 ! mannose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019310 name: inositol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, GOC:go_curators] subset: gosubset_prok synonym: "inositol breakdown" EXACT [] synonym: "inositol catabolism" EXACT [] synonym: "inositol degradation" EXACT [] synonym: "myo-inositol catabolic process" NARROW [] synonym: "myo-inositol catabolism" NARROW [] synonym: "vitamin Bh catabolic process" EXACT [] synonym: "vitamin Bh catabolism" EXACT [] xref: MetaCyc:P562-PWY is_a: GO:0006020 ! inositol metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0046174 ! polyol catabolic process [Term] id: GO:0019311 name: sorbose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sorbose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0019312 name: L-sorbose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [CHEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-sorbose metabolism" EXACT [] xref: MetaCyc:P302-PWY is_a: GO:0019311 ! sorbose metabolic process [Term] id: GO:0019313 name: allose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "allose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0019314 name: D-allose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [CHEBI:17393, GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-allose metabolism" EXACT [] is_a: GO:0019313 ! allose metabolic process [Term] id: GO:0019315 name: D-allose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [CHEBI:17393, GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-allose anabolism" EXACT [] synonym: "D-allose biosynthesis" EXACT [] synonym: "D-allose formation" EXACT [] synonym: "D-allose synthesis" EXACT [] is_a: GO:0019314 ! D-allose metabolic process is_a: GO:0046366 ! allose biosynthetic process [Term] id: GO:0019316 name: D-allose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [CHEBI:17393, GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-allose breakdown" EXACT [] synonym: "D-allose catabolism" EXACT [] synonym: "D-allose degradation" EXACT [] xref: MetaCyc:PWY0-44 is_a: GO:0019314 ! D-allose metabolic process is_a: GO:0046367 ! allose catabolic process [Term] id: GO:0019317 name: fucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose)." [GOC:jl] subset: gosubset_prok synonym: "fucose breakdown" EXACT [] synonym: "fucose catabolism" EXACT [] synonym: "fucose degradation" EXACT [] xref: MetaCyc:FUCCAT-PWY is_a: GO:0006004 ! fucose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019318 name: hexose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hexose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0019319 name: hexose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hexose anabolism" EXACT [] synonym: "hexose biosynthesis" EXACT [] synonym: "hexose formation" EXACT [] synonym: "hexose synthesis" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process [Term] id: GO:0019320 name: hexose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hexose breakdown" EXACT [] synonym: "hexose catabolism" EXACT [] synonym: "hexose degradation" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046365 ! monosaccharide catabolic process [Term] id: GO:0019321 name: pentose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0019322 name: pentose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentose anabolism" EXACT [] synonym: "pentose biosynthesis" EXACT [] synonym: "pentose formation" EXACT [] synonym: "pentose synthesis" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process [Term] id: GO:0019323 name: pentose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentose breakdown" EXACT [] synonym: "pentose catabolism" EXACT [] synonym: "pentose degradation" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0046365 ! monosaccharide catabolic process [Term] id: GO:0019324 name: L-lyxose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-lyxose metabolism" EXACT [] xref: MetaCyc:LYXMET-PWY is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0019325 name: anaerobic fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic fructose breakdown" EXACT [] synonym: "anaerobic fructose catabolism" EXACT [] synonym: "anaerobic fructose degradation" EXACT [] xref: MetaCyc:ANAEROFRUCAT-PWY is_a: GO:0006001 ! fructose catabolic process is_a: GO:0019317 ! fucose catabolic process [Term] id: GO:0019326 name: nitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] subset: gosubset_prok synonym: "nitrotoluene metabolism" EXACT [] is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0019327 name: lead sulfide oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate." [MetaCyc:P301-PWY] subset: gosubset_prok synonym: "lead sulphide oxidation" EXACT [GOC:mah] synonym: "oxidation of galena" EXACT [] synonym: "oxidation of lead sulfide" EXACT [GOC:curators] xref: MetaCyc:P301-PWY is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019328 name: anaerobic gallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen." [GOC:jl] subset: gosubset_prok synonym: "anaerobic gallate breakdown" EXACT [] synonym: "anaerobic gallate catabolism" EXACT [] synonym: "anaerobic gallate degradation" EXACT [] synonym: "anaerobic gallic acid catabolic process" EXACT [] synonym: "anaerobic gallic acid catabolism" EXACT [] synonym: "gallate fermentation" EXACT [] xref: MetaCyc:P3-PWY is_a: GO:0019396 ! gallate catabolic process [Term] id: GO:0019329 name: ammonia oxidation namespace: biological_process def: "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242] subset: gosubset_prok is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019330 name: aldoxime metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH." [CHEBI:22307, GOC:curators] synonym: "aldoxime metabolism" EXACT [] xref: MetaCyc:P345-PWY is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0019331 name: anaerobic respiration, using ammonium as electron donor namespace: biological_process def: "The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2." [MetaCyc:P303-PWY] subset: gosubset_prok synonym: "anaerobic ammonium oxidation" BROAD [] synonym: "anammox" EXACT [] xref: MetaCyc:P303-PWY xref: Wikipedia:Anammox is_a: GO:0009061 ! anaerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0019329 ! ammonia oxidation is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019332 name: aerobic respiration, using nitrite as electron donor namespace: biological_process def: "The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species." [MetaCyc:P282-PWY] subset: gosubset_prok synonym: "nitrite oxidation" BROAD [] xref: MetaCyc:P282-PWY is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019333 name: denitrification pathway namespace: biological_process def: "The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen." [MetaCyc:DENITRIFICATION-PWY] xref: MetaCyc:DENITRIFICATION-PWY is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0019334 name: p-cymene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [GOC:ai] subset: gosubset_prok synonym: "p-cymene breakdown" EXACT [] synonym: "p-cymene catabolism" EXACT [] synonym: "p-cymene degradation" EXACT [] xref: MetaCyc:PWY-741 is_a: GO:0018953 ! p-cymene metabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0019335 name: 3-methylquinoline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] subset: gosubset_prok synonym: "3-methylquinoline breakdown" EXACT [] synonym: "3-methylquinoline catabolism" EXACT [] synonym: "3-methylquinoline degradation" EXACT [] xref: MetaCyc:PWY-721 is_a: GO:0018930 ! 3-methylquinoline metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0019336 name: phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [CHEBI:33853, GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phenol-containing compound breakdown" EXACT [GOC:curators] synonym: "phenol-containing compound catabolism" EXACT [GOC:curators] synonym: "phenol-containing compound degradation" EXACT [GOC:curators] xref: MetaCyc:PHENOLDEG-PWY is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0019337 name: tetrachloroethylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GOC:ai] subset: gosubset_prok synonym: "tetrachloroethene catabolic process" EXACT [] synonym: "tetrachloroethene catabolism" EXACT [] synonym: "tetrachloroethylene breakdown" EXACT [] synonym: "tetrachloroethylene catabolism" EXACT [] synonym: "tetrachloroethylene degradation" EXACT [] xref: MetaCyc:PCEDEG-PWY is_a: GO:0018967 ! tetrachloroethylene metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process is_a: GO:0043451 ! alkene catabolic process [Term] id: GO:0019338 name: pentachlorophenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:go_curators] subset: gosubset_prok synonym: "pentachlorophenol breakdown" EXACT [] synonym: "pentachlorophenol catabolism" EXACT [] synonym: "pentachlorophenol degradation" EXACT [] xref: MetaCyc:PCPDEG-PWY is_a: GO:0018961 ! pentachlorophenol metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process [Term] id: GO:0019339 name: parathion catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [http://umbbd.ahc.umn.edu/pthn/pthn_map.html, UM-BBD_pathwayID:pthn] subset: gosubset_prok synonym: "parathion breakdown" EXACT [] synonym: "parathion catabolism" EXACT [] synonym: "parathion degradation" EXACT [] xref: MetaCyc:PARATHION-DEGRADATION-PWY is_a: GO:0018952 ! parathion metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0019340 name: dibenzofuran catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond." [GOC:ai] subset: gosubset_prok synonym: "dibenzofuran breakdown" EXACT [] synonym: "dibenzofuran catabolism" EXACT [] synonym: "dibenzofuran degradation" EXACT [] xref: MetaCyc:P662-PWY is_a: GO:0018893 ! dibenzofuran metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0019341 name: dibenzo-p-dioxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds." [GOC:ai] subset: gosubset_prok synonym: "dibenzo-p-dioxin breakdown" EXACT [] synonym: "dibenzo-p-dioxin catabolism" EXACT [] synonym: "dibenzo-p-dioxin degradation" EXACT [] xref: MetaCyc:P661-PWY is_a: GO:0018894 ! dibenzo-p-dioxin metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0019342 name: trypanothione biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress." [MetaCyc:TRYPANOSYN-PWY, PMID:9677355] subset: gosubset_prok synonym: "trypanothione anabolism" EXACT [] synonym: "trypanothione biosynthesis" EXACT [] synonym: "trypanothione formation" EXACT [] synonym: "trypanothione synthesis" EXACT [] xref: MetaCyc:TRYPANOSYN-PWY is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0046206 ! trypanothione metabolic process [Term] id: GO:0019343 name: cysteine biosynthetic process via cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine anabolism via cystathionine" EXACT [] synonym: "cysteine formation via cystathionine" EXACT [] synonym: "cysteine synthesis via cystathionine" EXACT [] is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0019344 name: cysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine anabolism" EXACT [] synonym: "cysteine biosynthesis" EXACT [] synonym: "cysteine formation" EXACT [] synonym: "cysteine synthesis" EXACT [] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process [Term] id: GO:0019345 name: cysteine biosynthetic process via S-sulfo-L-cysteine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine anabolism via S-sulfo-L-cysteine" EXACT [] synonym: "cysteine biosynthesis via S-sulpho-L-cysteine" EXACT [] synonym: "cysteine biosynthetic process via S-sulpho-L-cysteine" EXACT [] synonym: "cysteine formation via S-sulfo-L-cysteine" EXACT [] synonym: "cysteine synthesis via S-sulfo-L-cysteine" EXACT [] is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0019346 name: transsulfuration namespace: biological_process def: "The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes." [MetaCyc:PWY-801] subset: gosubset_prok synonym: "homocysteine-cysteine interconversion" NARROW [] synonym: "transsulphuration" EXACT [] xref: MetaCyc:PWY-801 xref: Wikipedia:Transsulfuration_pathway is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009092 ! homoserine metabolic process is_a: GO:0050667 ! homocysteine metabolic process [Term] id: GO:0019347 name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism" EXACT [] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis" EXACT [] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation" EXACT [] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis" EXACT [] xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0019408 ! dolichol biosynthetic process is_a: GO:0046376 ! GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process [Term] id: GO:0019348 name: dolichol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "dolichol metabolism" EXACT [] is_a: GO:0016093 ! polyprenol metabolic process [Term] id: GO:0019349 name: ribitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribitol metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0019350 name: teichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "teichoic acid anabolism" EXACT [] synonym: "teichoic acid biosynthesis" EXACT [] synonym: "teichoic acid formation" EXACT [] synonym: "teichoic acid synthesis" EXACT [] xref: MetaCyc:TEICHOICACID-PWY is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:0046374 ! teichoic acid metabolic process relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0019351 name: dethiobiotin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "desthiobiotin biosynthesis" EXACT [] synonym: "desthiobiotin biosynthetic process" EXACT [] synonym: "dethiobiotin anabolism" EXACT [] synonym: "dethiobiotin biosynthesis" EXACT [] synonym: "dethiobiotin formation" EXACT [] synonym: "dethiobiotin synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046450 ! dethiobiotin metabolic process relationship: part_of GO:0009102 ! biotin biosynthetic process [Term] id: GO:0019352 name: protoporphyrinogen IX biosynthetic process from glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine." [GOC:go_curators] subset: gosubset_prok synonym: "protoporphyrinogen IX anabolism from glycine" EXACT [] synonym: "protoporphyrinogen IX formation from glycine" EXACT [] synonym: "protoporphyrinogen IX synthesis from glycine" EXACT [] is_a: GO:0006544 ! glycine metabolic process is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process [Term] id: GO:0019353 name: protoporphyrinogen IX biosynthetic process from glutamate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate." [GOC:go_curators] subset: gosubset_prok synonym: "protoporphyrinogen IX anabolism from glutamate" EXACT [] synonym: "protoporphyrinogen IX formation from glutamate" EXACT [] synonym: "protoporphyrinogen IX synthesis from glutamate" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process is_a: GO:0033526 ! tetrapyrrole biosynthetic process from glutamate [Term] id: GO:0019354 name: siroheme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sirohaem biosynthesis" EXACT [] synonym: "sirohaem biosynthetic process" EXACT [] synonym: "siroheme anabolism" EXACT [] synonym: "siroheme biosynthesis" EXACT [] synonym: "siroheme formation" EXACT [] synonym: "siroheme synthase activity" RELATED [] synonym: "siroheme synthesis" EXACT [] xref: AraCyc:PWYQT-62 xref: MetaCyc:PWY-5194 is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046156 ! siroheme metabolic process [Term] id: GO:0019355 name: nicotinamide nucleotide biosynthetic process from aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate." [GOC:go_curators] subset: gosubset_prok synonym: "nicotinamide nucleotide anabolism from aspartate" EXACT [] synonym: "nicotinamide nucleotide formation from aspartate" EXACT [] synonym: "nicotinamide nucleotide synthesis from aspartate" EXACT [] is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0019356 name: nicotinate nucleotide biosynthetic process from tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan." [GOC:go_curators] subset: gosubset_prok synonym: "nicotinate nucleotide anabolism from tryptophan" EXACT [] synonym: "nicotinate nucleotide formation from tryptophan" EXACT [] synonym: "nicotinate nucleotide synthesis from tryptophan" EXACT [] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process [Term] id: GO:0019357 name: nicotinate nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid)." [GOC:go_curators] subset: gosubset_prok synonym: "nicotinate nucleotide anabolism" EXACT [] synonym: "nicotinate nucleotide biosynthesis" EXACT [] synonym: "nicotinate nucleotide formation" EXACT [] synonym: "nicotinate nucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0046497 ! nicotinate nucleotide metabolic process [Term] id: GO:0019358 name: nicotinate nucleotide salvage namespace: biological_process def: "The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators] subset: gosubset_prok synonym: "nicotinate nucleotide biosynthesis, salvage pathway" EXACT [] synonym: "nicotinate nucleotide biosynthetic process, salvage pathway" EXACT [] xref: MetaCyc:PWY-5381 xref: MetaCyc:PYRIDNUCSAL-PWY is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process is_a: GO:0019365 ! pyridine nucleotide salvage [Term] id: GO:0019359 name: nicotinamide nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators] subset: gosubset_prok synonym: "nicotinamide nucleotide anabolism" EXACT [] synonym: "nicotinamide nucleotide biosynthesis" EXACT [] synonym: "nicotinamide nucleotide formation" EXACT [] synonym: "nicotinamide nucleotide synthesis" EXACT [] is_a: GO:0019363 ! pyridine nucleotide biosynthetic process is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0019360 name: nicotinamide nucleotide biosynthetic process from niacinamide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide." [GOC:go_curators] subset: gosubset_prok synonym: "nicotinamide nucleotide anabolism from niacinamide" EXACT [] synonym: "nicotinamide nucleotide formation from niacinamide" EXACT [] synonym: "nicotinamide nucleotide synthesis from niacinamide" EXACT [] is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0019361 name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] subset: gosubset_prok synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT [] xref: MetaCyc:P2-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process [Term] id: GO:0019362 name: pyridine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] subset: gosubset_prok synonym: "pyridine nucleotide metabolism" EXACT [] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0019363 name: pyridine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] subset: gosubset_prok synonym: "pyridine nucleotide anabolism" EXACT [] synonym: "pyridine nucleotide biosynthesis" EXACT [] synonym: "pyridine nucleotide formation" EXACT [] synonym: "pyridine nucleotide synthesis" EXACT [] xref: MetaCyc:PYRIDNUCSYN-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process [Term] id: GO:0019364 name: pyridine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] subset: gosubset_prok synonym: "pyridine nucleotide breakdown" EXACT [] synonym: "pyridine nucleotide catabolism" EXACT [] synonym: "pyridine nucleotide degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process [Term] id: GO:0019365 name: pyridine nucleotide salvage namespace: biological_process def: "Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "pyridine nucleotide cycling" EXACT [] is_a: GO:0019363 ! pyridine nucleotide biosynthetic process is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0019367 name: fatty acid elongation, saturated fatty acid namespace: biological_process def: "Elongation of a saturated fatty acid chain." [GOC:mah] subset: gosubset_prok xref: MetaCyc:FASYN-ELONG-PWY is_a: GO:0030497 ! fatty acid elongation [Term] id: GO:0019368 name: fatty acid elongation, unsaturated fatty acid namespace: biological_process def: "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah] subset: gosubset_prok xref: MetaCyc:PWY0-862 is_a: GO:0030497 ! fatty acid elongation [Term] id: GO:0019369 name: arachidonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "arachidonic acid metabolism" EXACT [] xref: Wikipedia:Arachidonic_acid is_a: GO:0000038 ! very long-chain fatty acid metabolic process is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0019370 name: leukotriene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:go_curators] subset: gosubset_prok synonym: "leukotriene anabolism" EXACT [] synonym: "leukotriene biosynthesis" EXACT [] synonym: "leukotriene formation" EXACT [] synonym: "leukotriene synthesis" EXACT [] xref: Reactome:1253595 "Leukotriene synthesis" xref: Reactome:1280526 "Leukotriene synthesis" xref: Reactome:1299357 "Leukotriene synthesis" xref: Reactome:1327112 "Leukotriene synthesis" xref: Reactome:1353207 "Leukotriene synthesis" xref: Reactome:1373383 "Leukotriene synthesis" xref: Reactome:1393408 "Leukotriene synthesis" xref: Reactome:1417903 "Leukotriene synthesis" xref: Reactome:1450993 "Leukotriene synthesis" xref: Reactome:1471379 "Leukotriene synthesis" xref: Reactome:1483335 "Leukotriene synthesis" xref: Reactome:1497017 "Leukotriene synthesis" xref: Reactome:1514404 "Leukotriene synthesis" xref: Reactome:1521273 "Leukotriene synthesis" xref: Reactome:1526978 "Leukotriene synthesis" xref: Reactome:1532713 "Leukotriene synthesis" xref: Reactome:1538073 "Leukotriene synthesis" xref: Reactome:265309 "Leukotriene synthesis" xref: Wikipedia:Leukotriene#Leukotriene_synthesis is_a: GO:0006691 ! leukotriene metabolic process is_a: GO:0043450 ! alkene biosynthetic process is_a: GO:0046456 ! icosanoid biosynthetic process [Term] id: GO:0019371 name: cyclooxygenase pathway namespace: biological_process def: "The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2." [PMID:19854273] subset: gosubset_prok is_a: GO:0019369 ! arachidonic acid metabolic process relationship: part_of GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0019372 name: lipoxygenase pathway namespace: biological_process def: "The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase." [GOC:mah, PMID:17163881] subset: gosubset_prok is_a: GO:0000038 ! very long-chain fatty acid metabolic process is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0019373 name: epoxygenase P450 pathway namespace: biological_process def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids." [GOC:mah, PMID:17979511] subset: gosubset_prok is_a: GO:0019369 ! arachidonic acid metabolic process [Term] id: GO:0019374 name: galactolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactolipid metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process [Term] id: GO:0019375 name: galactolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactolipid anabolism" EXACT [] synonym: "galactolipid biosynthesis" EXACT [] synonym: "galactolipid formation" EXACT [] synonym: "galactolipid synthesis" EXACT [] is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0019374 ! galactolipid metabolic process [Term] id: GO:0019376 name: galactolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactolipid breakdown" EXACT [] synonym: "galactolipid catabolism" EXACT [] synonym: "galactolipid degradation" EXACT [] is_a: GO:0019374 ! galactolipid metabolic process is_a: GO:0019377 ! glycolipid catabolic process [Term] id: GO:0019377 name: glycolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators] subset: gosubset_prok synonym: "glycolipid breakdown" EXACT [] synonym: "glycolipid catabolism" EXACT [] synonym: "glycolipid degradation" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046466 ! membrane lipid catabolic process [Term] id: GO:0019379 name: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) namespace: biological_process def: "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8)." [GOC:jl] subset: gosubset_prok synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin)" EXACT [] xref: MetaCyc:SO4ASSIM-PWY is_a: GO:0000103 ! sulfate assimilation is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0019380 name: 3-phenylpropionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid." [GOC:ai] subset: gosubset_prok synonym: "3-phenylpropionate breakdown" EXACT [] synonym: "3-phenylpropionate catabolism" EXACT [] synonym: "3-phenylpropionate degradation" EXACT [] xref: MetaCyc:HCAMHPDEG-PWY xref: MetaCyc:P281-PWY is_a: GO:0018962 ! 3-phenylpropionate metabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0019381 name: atrazine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, http://umbbd.ahc.umn.edu/atr/atr_map.html, UM-BBD_pathwayID:atr] subset: gosubset_prok synonym: "atrazine breakdown" EXACT [] synonym: "atrazine catabolism" EXACT [] synonym: "atrazine degradation" EXACT [] xref: MetaCyc:P141-PWY is_a: GO:0018873 ! atrazine metabolic process is_a: GO:0042204 ! s-triazine compound catabolic process [Term] id: GO:0019382 name: carbon tetrachloride catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [GOC:go_curators] subset: gosubset_prok synonym: "carbon tetrachloride breakdown" EXACT [] synonym: "carbon tetrachloride catabolism" EXACT [] synonym: "carbon tetrachloride degradation" EXACT [] is_a: GO:0018885 ! carbon tetrachloride metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process [Term] id: GO:0019383 name: (+)-camphor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [http://umbbd.ahc.umn.edu/cam/cam_map.html, UM-BBD_pathwayID:cam] subset: gosubset_prok synonym: "(+)-camphor breakdown" EXACT [] synonym: "(+)-camphor catabolism" EXACT [] synonym: "(+)-camphor degradation" EXACT [] xref: MetaCyc:P601-PWY is_a: GO:0018882 ! (+)-camphor metabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0043694 ! monoterpene catabolic process [Term] id: GO:0019384 name: caprolactam catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [CHEBI:23000, GOC:curators] subset: gosubset_prok synonym: "caprolactam breakdown" EXACT [] synonym: "caprolactam catabolism" EXACT [] synonym: "caprolactam degradation" EXACT [] xref: MetaCyc:P621-PWY is_a: GO:0018883 ! caprolactam metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072340 ! cellular lactam catabolic process [Term] id: GO:0019385 name: methanogenesis, from acetate namespace: biological_process def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate." [GOC:ai] subset: gosubset_prok synonym: "methane biosynthesis from acetate" EXACT [] synonym: "methane biosynthetic process from acetate" EXACT [] xref: MetaCyc:METH-ACETATE-PWY is_a: GO:0015948 ! methanogenesis [Term] id: GO:0019386 name: methanogenesis, from carbon dioxide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2)." [GOC:ai] subset: gosubset_prok synonym: "methane biosynthesis from carbon dioxide" EXACT [] synonym: "methane biosynthetic process from carbon dioxide" EXACT [] xref: MetaCyc:METHANOGENESIS-PWY is_a: GO:0015948 ! methanogenesis [Term] id: GO:0019387 name: methanogenesis, from methanol namespace: biological_process def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol." [GOC:ai] subset: gosubset_prok synonym: "methane biosynthesis from methanol" EXACT [] synonym: "methane biosynthetic process from methanol" EXACT [] xref: MetaCyc:METHFORM-PWY is_a: GO:0015948 ! methanogenesis [Term] id: GO:0019388 name: galactose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactose breakdown" EXACT [] synonym: "galactose catabolism" EXACT [] synonym: "galactose degradation" EXACT [] xref: MetaCyc:GALDEG-PWY xref: Reactome:1252921 "Galactose catabolism" xref: Reactome:1279855 "Galactose catabolism" xref: Reactome:1298770 "Galactose catabolism" xref: Reactome:1326424 "Galactose catabolism" xref: Reactome:1352540 "Galactose catabolism" xref: Reactome:1372768 "Galactose catabolism" xref: Reactome:1392778 "Galactose catabolism" xref: Reactome:1417255 "Galactose catabolism" xref: Reactome:1450343 "Galactose catabolism" xref: Reactome:1470884 "Galactose catabolism" xref: Reactome:1482916 "Galactose catabolism" xref: Reactome:1496712 "Galactose catabolism" xref: Reactome:1514103 "Galactose catabolism" xref: Reactome:1520928 "Galactose catabolism" xref: Reactome:1526673 "Galactose catabolism" xref: Reactome:1532400 "Galactose catabolism" xref: Reactome:1537970 "Galactose catabolism" xref: Reactome:1539224 "Galactose catabolism" xref: Reactome:1540281 "Galactose catabolism" xref: Reactome:70370 "Galactose catabolism" is_a: GO:0006012 ! galactose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019389 name: glucuronoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucuronide metabolic process" EXACT [] synonym: "glucuronide metabolism" EXACT [] synonym: "glucuronoside metabolism" EXACT [] is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0019390 name: glucuronoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucuronide biosynthesis" EXACT [] synonym: "glucuronide biosynthetic process" EXACT [] synonym: "glucuronoside anabolism" EXACT [] synonym: "glucuronoside biosynthesis" EXACT [] synonym: "glucuronoside formation" EXACT [] synonym: "glucuronoside synthesis" EXACT [] is_a: GO:0019389 ! glucuronoside metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process [Term] id: GO:0019391 name: glucuronoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucuronide catabolic process" EXACT [] synonym: "glucuronide catabolism" EXACT [] synonym: "glucuronoside breakdown" EXACT [] synonym: "glucuronoside catabolism" EXACT [] synonym: "glucuronoside degradation" EXACT [] xref: MetaCyc:GLUCUROCAT-PWY is_a: GO:0019389 ! glucuronoside metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0019392 name: glucarate metabolic process namespace: biological_process alt_id: GO:0019581 def: "The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucarate metabolism" EXACT [] is_a: GO:0019577 ! aldaric acid metabolic process [Term] id: GO:0019393 name: glucarate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucarate anabolism" EXACT [] synonym: "glucarate biosynthesis" EXACT [] synonym: "glucarate formation" EXACT [] synonym: "glucarate synthesis" EXACT [] is_a: GO:0019392 ! glucarate metabolic process is_a: GO:0019578 ! aldaric acid biosynthetic process [Term] id: GO:0019394 name: glucarate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucarate breakdown" EXACT [] synonym: "glucarate catabolism" EXACT [] synonym: "glucarate degradation" EXACT [] xref: MetaCyc:GLUCARDEG-PWY is_a: GO:0019392 ! glucarate metabolic process is_a: GO:0019579 ! aldaric acid catabolic process [Term] id: GO:0019395 name: fatty acid oxidation namespace: biological_process def: "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:FAO-PWY] subset: gosubset_prok xref: MetaCyc:FAO-PWY is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0034440 ! lipid oxidation [Term] id: GO:0019396 name: gallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:jl] subset: gosubset_prok synonym: "gallate breakdown" EXACT [] synonym: "gallate catabolism" EXACT [] synonym: "gallate degradation" EXACT [] synonym: "gallic acid catabolic process" EXACT [] synonym: "gallic acid catabolism" EXACT [] is_a: GO:0018918 ! gallate metabolic process is_a: GO:0019614 ! catechol catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019397 name: gallate catabolic process via 2-pyrone-4,6-dicarboxylate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate." [GOC:jl] subset: gosubset_prok synonym: "gallate breakdown via 2-pyrone-4,6-dicarboxylate" EXACT [] synonym: "gallate degradation via 2-pyrone-4,6-dicarboxylate" EXACT [] synonym: "gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate" EXACT [] synonym: "gallic acid catabolism via 2-pyrone-4,6-dicarboxylate" EXACT [] xref: MetaCyc:GALLATE-DEGRADATION-I-PWY is_a: GO:0042195 ! aerobic gallate catabolic process [Term] id: GO:0019398 name: gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 4-carboxy-2-hydroxhexa-2,3-dienedioate." [GOC:jl] subset: gosubset_prok synonym: "gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] synonym: "gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] synonym: "gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] synonym: "gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] xref: MetaCyc:GALLATE-DEGRADATION-II-PWY is_a: GO:0042195 ! aerobic gallate catabolic process [Term] id: GO:0019399 name: cyclohexanol oxidation namespace: biological_process def: "The cyclohexanol metabolic process in which cyclohexanol is converted to adipate." [MetaCyc:CYCLOHEXANOL-OXIDATION-PWY] subset: gosubset_prok xref: MetaCyc:CYCLOHEXANOL-OXIDATION-PWY is_a: GO:0018891 ! cyclohexanol metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019400 name: alditol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alditol metabolism" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0019401 name: alditol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alditol anabolism" EXACT [] synonym: "alditol biosynthesis" EXACT [] synonym: "alditol formation" EXACT [] synonym: "alditol synthesis" EXACT [] is_a: GO:0019400 ! alditol metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process [Term] id: GO:0019402 name: galactitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactitol metabolism" EXACT [] is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0019403 name: galactitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactitol anabolism" EXACT [] synonym: "galactitol biosynthesis" EXACT [] synonym: "galactitol formation" EXACT [] synonym: "galactitol synthesis" EXACT [] is_a: GO:0019402 ! galactitol metabolic process is_a: GO:0019406 ! hexitol biosynthetic process [Term] id: GO:0019404 name: galactitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactitol breakdown" EXACT [] synonym: "galactitol catabolism" EXACT [] synonym: "galactitol degradation" EXACT [] xref: MetaCyc:GALACTITOLCAT-PWY is_a: GO:0019402 ! galactitol metabolic process is_a: GO:0019407 ! hexitol catabolic process [Term] id: GO:0019405 name: alditol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alditol breakdown" EXACT [] synonym: "alditol catabolism" EXACT [] synonym: "alditol degradation" EXACT [] is_a: GO:0019400 ! alditol metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0046174 ! polyol catabolic process [Term] id: GO:0019406 name: hexitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hexitol anabolism" EXACT [] synonym: "hexitol biosynthesis" EXACT [] synonym: "hexitol formation" EXACT [] synonym: "hexitol synthesis" EXACT [] is_a: GO:0006059 ! hexitol metabolic process is_a: GO:0019401 ! alditol biosynthetic process [Term] id: GO:0019407 name: hexitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hexitol breakdown" EXACT [] synonym: "hexitol catabolism" EXACT [] synonym: "hexitol degradation" EXACT [] is_a: GO:0006059 ! hexitol metabolic process is_a: GO:0019405 ! alditol catabolic process [Term] id: GO:0019408 name: dolichol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "dolichol anabolism" EXACT [] synonym: "dolichol biosynthesis" EXACT [] synonym: "dolichol formation" EXACT [] synonym: "dolichol synthesis" EXACT [] is_a: GO:0016094 ! polyprenol biosynthetic process is_a: GO:0019348 ! dolichol metabolic process [Term] id: GO:0019409 name: aerobic respiration, using ammonia as electron donor namespace: biological_process def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite." [MetaCyc:AMMOXID-PWY] subset: gosubset_prok synonym: "aerobic ammonia oxidation to nitrite via hydrazine" EXACT [GOC:mah] xref: MetaCyc:AMMOXID-PWY is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0019329 ! ammonia oxidation is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019410 name: aerobic respiration, using carbon monoxide as electron donor namespace: biological_process def: "The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation." [PMID:18024677] subset: gosubset_prok is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019411 name: aerobic respiration, using ferrous ions as electron donor namespace: biological_process def: "The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide." [ISBN:3131084111] subset: gosubset_prok is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019412 name: aerobic respiration, using hydrogen as electron donor namespace: biological_process def: "The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water." [MetaCyc:P283-PWY] subset: gosubset_prok synonym: "hydrogen oxidation" BROAD [] xref: MetaCyc:P283-PWY is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019413 name: acetate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators] subset: gosubset_prok synonym: "acetate anabolism" EXACT [] synonym: "acetate biosynthesis" EXACT [] synonym: "acetate formation" EXACT [] synonym: "acetate synthesis" EXACT [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0019414 name: aerobic respiration, using sulfur or sulfate as electron donor namespace: biological_process def: "An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized." [PMID:11425697] subset: gosubset_prok synonym: "aerobic respiration, using sulphur or sulphate as electron donor" EXACT [] is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019415 name: acetate biosynthetic process from carbon monoxide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide." [GOC:go_curators] subset: gosubset_prok synonym: "acetate anabolism from carbon monoxide" EXACT [] synonym: "acetate formation from carbon monoxide" EXACT [] synonym: "acetate synthesis from carbon monoxide" EXACT [] synonym: "carbon monoxide dehydrogenase pathway" EXACT [] xref: MetaCyc:CODH-PWY is_a: GO:0019413 ! acetate biosynthetic process [Term] id: GO:0019416 name: polythionate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor." [MetaCyc:THIOSULFOX-PWY] subset: gosubset_prok xref: MetaCyc:THIOSULFOX-PWY is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019417 name: sulfur oxidation namespace: biological_process def: "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY] subset: gosubset_prok synonym: "sulphur oxidation" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019418 name: sulfide oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:P222-PWY, MetaCyc:P223-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285] subset: gosubset_prok synonym: "sulphide oxidation" EXACT [] xref: MetaCyc:P222-PWY is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019419 name: sulfate reduction namespace: biological_process alt_id: GO:0019421 def: "The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate." [MetaCyc:DISSULFRED-PWY, MetaCyc:P224-PWY, MetaCyc:SO4ASSIM-PWY, MetaCyc:SULFMETII-PWY] subset: gosubset_prok synonym: "assimilatory sulfate reduction" NARROW [] synonym: "assimilatory sulphate reduction" NARROW [] synonym: "sulfate reduction, APS pathway" NARROW [] synonym: "sulphate reduction" EXACT [] synonym: "sulphate reduction, APS pathway" NARROW [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019420 name: dissimilatory sulfate reduction namespace: biological_process def: "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [GOC:jl, MetaCyc:DISSULFRED-PWY] subset: gosubset_prok synonym: "dissimilatory sulphate reduction" EXACT [] xref: MetaCyc:DISSULFRED-PWY is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0019422 name: disproportionation of elemental sulfur namespace: biological_process def: "The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2." [MetaCyc:P203-PWY] subset: gosubset_prok synonym: "disproportionation of elemental sulphur" EXACT [] xref: MetaCyc:P203-PWY is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0019423 name: sulfur oxidation, ferric ion-dependent namespace: biological_process def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+)." [MetaCyc:FESULFOX-PWY] subset: gosubset_prok synonym: "sulphur oxidation, ferric ion-dependent" EXACT [] xref: MetaCyc:FESULFOX-PWY is_a: GO:0019417 ! sulfur oxidation [Term] id: GO:0019424 name: sulfide oxidation, using siroheme sulfite reductase namespace: biological_process alt_id: GO:0019425 def: "A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase." [MetaCyc:P223-PWY] subset: gosubset_prok synonym: "sulfide oxidation, using sirohaem sulfite reductase" EXACT [] synonym: "sulfur oxidation, using sirohaem sulfite reductase" RELATED [] synonym: "sulfur oxidation, using siroheme sulfite reductase" RELATED [] synonym: "sulphide oxidation, using siroheme sulphite reductase" EXACT [] synonym: "sulphur oxidation, using siroheme sulphite reductase" RELATED [] xref: MetaCyc:P223-PWY is_a: GO:0019418 ! sulfide oxidation [Term] id: GO:0019426 name: bisulfite reduction namespace: biological_process def: "The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite." [MetaCyc:P224-PWY] subset: gosubset_prok synonym: "bisulphite reduction" EXACT [] xref: MetaCyc:P224-PWY is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0019427 name: acetyl-CoA biosynthetic process from acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY] subset: gosubset_prok synonym: "acetate utilization" RELATED [] synonym: "acetyl-CoA anabolism from acetate" EXACT [] synonym: "acetyl-CoA formation from acetate" EXACT [] synonym: "acetyl-CoA synthesis from acetate" EXACT [] xref: MetaCyc:ACETATEUTIL-PWY is_a: GO:0006083 ! acetate metabolic process is_a: GO:0006085 ! acetyl-CoA biosynthetic process [Term] id: GO:0019428 name: allantoin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators] subset: gosubset_prok synonym: "allantoin anabolism" EXACT [] synonym: "allantoin biosynthesis" EXACT [] synonym: "allantoin formation" EXACT [] synonym: "allantoin synthesis" EXACT [] xref: MetaCyc:URSIN-PWY is_a: GO:0000255 ! allantoin metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0019429 name: fluorene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:go_curators] subset: gosubset_prok synonym: "fluorene breakdown" EXACT [] synonym: "fluorene catabolism" EXACT [] synonym: "fluorene degradation" EXACT [] xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY is_a: GO:0018917 ! fluorene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0019430 name: removal of superoxide radicals namespace: biological_process def: "Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl] subset: gosubset_prok synonym: "removal of O2-" EXACT [] synonym: "removal of oxygen free radicals" EXACT [] xref: MetaCyc:DETOX1-PWY is_a: GO:0006801 ! superoxide metabolic process is_a: GO:0071451 ! cellular response to superoxide [Term] id: GO:0019431 name: acetyl-CoA biosynthetic process from ethanol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde." [GOC:go_curators] subset: gosubset_prok synonym: "acetyl-CoA anabolism from ethanol" EXACT [] synonym: "acetyl-CoA formation from ethanol" EXACT [] synonym: "acetyl-CoA synthesis from ethanol" EXACT [] xref: MetaCyc:ETOH-ACETYLCOA-ANA-PWY is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0006085 ! acetyl-CoA biosynthetic process [Term] id: GO:0019432 name: triglyceride biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "triacylglycerol biosynthesis" EXACT [] synonym: "triacylglycerol biosynthetic process" EXACT [] synonym: "triglyceride anabolism" EXACT [] synonym: "triglyceride biosynthesis" EXACT [] synonym: "triglyceride formation" EXACT [] synonym: "triglyceride synthesis" EXACT [] xref: MetaCyc:TRIGLSYN-PWY xref: Reactome:1253063 "Triglyceride Biosynthesis" xref: Reactome:1279999 "Triglyceride Biosynthesis" xref: Reactome:1298892 "Triglyceride Biosynthesis" xref: Reactome:1326569 "Triglyceride Biosynthesis" xref: Reactome:1352681 "Triglyceride Biosynthesis" xref: Reactome:1372897 "Triglyceride Biosynthesis" xref: Reactome:1392915 "Triglyceride Biosynthesis" xref: Reactome:1417390 "Triglyceride Biosynthesis" xref: Reactome:1450488 "Triglyceride Biosynthesis" xref: Reactome:1471001 "Triglyceride Biosynthesis" xref: Reactome:1483026 "Triglyceride Biosynthesis" xref: Reactome:1496794 "Triglyceride Biosynthesis" xref: Reactome:1514184 "Triglyceride Biosynthesis" xref: Reactome:1521020 "Triglyceride Biosynthesis" xref: Reactome:1526758 "Triglyceride Biosynthesis" xref: Reactome:1532489 "Triglyceride Biosynthesis" xref: Reactome:1536023 "Triglyceride Biosynthesis" xref: Reactome:1538006 "Triglyceride Biosynthesis" xref: Reactome:1539269 "Triglyceride Biosynthesis" xref: Reactome:1540311 "Triglyceride Biosynthesis" xref: Reactome:75109 "Triglyceride Biosynthesis" is_a: GO:0006641 ! triglyceride metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0019433 name: triglyceride catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "triacylglycerol catabolic process" EXACT [] synonym: "triacylglycerol catabolism" EXACT [] synonym: "triglyceride breakdown" EXACT [] synonym: "triglyceride catabolism" EXACT [] synonym: "triglyceride degradation" EXACT [] xref: MetaCyc:LIPAS-PWY xref: Reactome:1253332 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1280270 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1299127 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1326848 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1352941 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1373147 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1393163 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1417649 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1450750 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1471190 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1483183 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1521135 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1526893 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1532622 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1538036 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:1539319 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" xref: Reactome:163560 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis" is_a: GO:0006641 ! triglyceride metabolic process is_a: GO:0046464 ! acylglycerol catabolic process [Term] id: GO:0019434 name: sophorosyloxydocosanoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE] subset: gosubset_prok synonym: "sophorosyloxydocosanoate metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process [Term] id: GO:0019435 name: sophorosyloxydocosanoate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] subset: gosubset_prok synonym: "sophorosyloxydocosanoate anabolism" EXACT [] synonym: "sophorosyloxydocosanoate biosynthesis" EXACT [] synonym: "sophorosyloxydocosanoate formation" EXACT [] synonym: "sophorosyloxydocosanoate synthesis" EXACT [] xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-SYN-PWY is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process [Term] id: GO:0019436 name: sophorosyloxydocosanoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] subset: gosubset_prok synonym: "sophorosyloxydocosanoate breakdown" EXACT [] synonym: "sophorosyloxydocosanoate catabolism" EXACT [] synonym: "sophorosyloxydocosanoate degradation" EXACT [] xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-DEG-PWY is_a: GO:0019377 ! glycolipid catabolic process is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process [Term] id: GO:0019438 name: aromatic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] subset: gosubset_prok synonym: "aromatic compound anabolism" EXACT [] synonym: "aromatic compound biosynthesis" EXACT [] synonym: "aromatic compound formation" EXACT [] synonym: "aromatic compound synthesis" EXACT [] synonym: "aromatic hydrocarbon biosynthesis" NARROW [] synonym: "aromatic hydrocarbon biosynthetic process" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0019439 name: aromatic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] subset: gosubset_prok synonym: "aromatic compound breakdown" EXACT [] synonym: "aromatic compound catabolism" EXACT [] synonym: "aromatic compound degradation" EXACT [] synonym: "aromatic hydrocarbon catabolic process" NARROW [] synonym: "aromatic hydrocarbon catabolism" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0019440 name: tryptophan catabolic process to indole-3-acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate." [GOC:go_curators] subset: gosubset_prok synonym: "tryptophan breakdown to indole-3-acetate" EXACT [] synonym: "tryptophan catabolic process to IAA" EXACT [] synonym: "tryptophan catabolic process to indoleacetic acid" EXACT [] synonym: "tryptophan catabolism to indoleacetic acid" EXACT [] synonym: "tryptophan degradation to indole-3-acetate" EXACT [] xref: MetaCyc:TRPIAACAT-PWY is_a: GO:0006569 ! tryptophan catabolic process is_a: GO:0009683 ! indoleacetic acid metabolic process [Term] id: GO:0019441 name: tryptophan catabolic process to kynurenine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators] subset: gosubset_prok synonym: "tryptophan breakdown to kynurenine" EXACT [] synonym: "tryptophan degradation to kynurenine" EXACT [] xref: MetaCyc:TRPKYNCAT-PWY is_a: GO:0006569 ! tryptophan catabolic process is_a: GO:0070189 ! kynurenine metabolic process [Term] id: GO:0019442 name: tryptophan catabolic process to acetyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA." [GOC:go_curators] subset: gosubset_prok synonym: "tryptophan breakdown to acetyl-CoA" EXACT [] synonym: "tryptophan degradation to acetyl-CoA" EXACT [] xref: MetaCyc:TRYPTOPHAN-DEGRADATION-1 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0006569 ! tryptophan catabolic process [Term] id: GO:0019443 name: tryptophan catabolic process, using tryptophanase namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1)." [GOC:jl] comment: This term was made obsolete because it refers to a one-step pathway. synonym: "tryptophan breakdown, using tryptophanase" EXACT [] synonym: "tryptophan degradation, using tryptophanase" EXACT [] is_obsolete: true replaced_by: GO:0006569 replaced_by: GO:0009034 [Term] id: GO:0019444 name: tryptophan catabolic process to catechol namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol." [GOC:go_curators] subset: gosubset_prok synonym: "tryptophan breakdown to catechol" EXACT [] synonym: "tryptophan degradation to catechol" EXACT [] xref: MetaCyc:TRPCAT-PWY is_a: GO:0006569 ! tryptophan catabolic process is_a: GO:0009712 ! catechol metabolic process [Term] id: GO:0019445 name: tyrosine catabolic process to fumarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate." [GOC:go_curators] subset: gosubset_prok synonym: "tyrosine breakdown to fumarate" EXACT [] synonym: "tyrosine degradation to fumarate" EXACT [] xref: MetaCyc:TYRFUMCAT-PWY is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0006572 ! tyrosine catabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019446 name: tyrosine catabolic process to phosphoenolpyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] subset: gosubset_prok synonym: "tyrosine breakdown to phosphoenolpyruvate" EXACT [] synonym: "tyrosine degradation to phosphoenolpyruvate" EXACT [] is_a: GO:0006572 ! tyrosine catabolic process [Term] id: GO:0019447 name: D-cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-cysteine breakdown" EXACT [] synonym: "D-cysteine catabolism" EXACT [] synonym: "D-cysteine degradation" EXACT [] is_a: GO:0009093 ! cysteine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0046438 ! D-cysteine metabolic process [Term] id: GO:0019448 name: L-cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [CHEBI:17561, GOC:go_curators, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-cysteine breakdown" EXACT [] synonym: "L-cysteine catabolism" EXACT [] synonym: "L-cysteine degradation" EXACT [] is_a: GO:0009093 ! cysteine catabolic process is_a: GO:0046439 ! L-cysteine metabolic process [Term] id: GO:0019449 name: L-cysteine catabolic process to hypotaurine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators] subset: gosubset_prok synonym: "L-cysteine breakdown to hypotaurine" EXACT [] synonym: "L-cysteine degradation to hypotaurine" EXACT [] is_a: GO:0019448 ! L-cysteine catabolic process [Term] id: GO:0019450 name: L-cysteine catabolic process to pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate." [GOC:go_curators] subset: gosubset_prok synonym: "L-cysteine breakdown to pyruvate" EXACT [] synonym: "L-cysteine degradation to pyruvate" EXACT [] xref: MetaCyc:LCYSDEG-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0019448 ! L-cysteine catabolic process [Term] id: GO:0019451 name: L-cysteine catabolic process to pyruvate, using cysteine dioxygenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20)." [GOC:jl] subset: gosubset_prok synonym: "L-cysteine breakdown to pyruvate, using cysteine dioxygenase" EXACT [] synonym: "L-cysteine degradation to pyruvate, using cysteine dioxygenase" EXACT [] xref: MetaCyc:CYSTEINE-DEG-PWY is_a: GO:0019450 ! L-cysteine catabolic process to pyruvate [Term] id: GO:0019452 name: L-cysteine catabolic process to taurine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators] subset: gosubset_prok synonym: "L-cysteine breakdown to taurine" EXACT [] synonym: "L-cysteine degradation to taurine" EXACT [] is_a: GO:0019448 ! L-cysteine catabolic process is_a: GO:0019530 ! taurine metabolic process [Term] id: GO:0019453 name: L-cysteine catabolic process via cystine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine." [GOC:go_curators] subset: gosubset_prok synonym: "L-cysteine breakdown via cystine" EXACT [] synonym: "L-cysteine degradation via cystine" EXACT [] is_a: GO:0019448 ! L-cysteine catabolic process [Term] id: GO:0019454 name: L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase (EC:1.8.4.4)." [GOC:jl] subset: gosubset_prok synonym: "L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase" EXACT [] synonym: "L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase" EXACT [] is_a: GO:0019453 ! L-cysteine catabolic process via cystine [Term] id: GO:0019455 name: L-cysteine catabolic process via cystine, using cystine reductase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase (EC:1.8.1.6)." [GOC:jl] subset: gosubset_prok synonym: "L-cysteine breakdown via cystine, using cystine reductase" EXACT [] synonym: "L-cysteine degradation via cystine, using cystine reductase" EXACT [] is_a: GO:0019453 ! L-cysteine catabolic process via cystine [Term] id: GO:0019456 name: L-cysteine catabolic process via cystine, using cysteine transaminase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase (EC:2.6.1.3)." [GOC:jl] subset: gosubset_prok synonym: "L-cysteine breakdown via cystine, using cysteine transaminase" EXACT [] synonym: "L-cysteine degradation via cystine, using cysteine transaminase" EXACT [] is_a: GO:0019453 ! L-cysteine catabolic process via cystine [Term] id: GO:0019457 name: methionine catabolic process to succinyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA." [GOC:go_curators] subset: gosubset_prok synonym: "methionine breakdown to succinyl-CoA" EXACT [] synonym: "methionine degradation to succinyl-CoA" EXACT [] xref: MetaCyc:METHIONINE-DEG1-PWY is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0019458 name: methionine catabolic process via 2-oxobutanoate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate." [GOC:go_curators] subset: gosubset_prok synonym: "methionine breakdown via 2-oxobutanoate" EXACT [] synonym: "methionine degradation via 2-oxobutanoate" EXACT [] xref: MetaCyc:PWY-701 is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0019460 name: glutamate catabolic process to fumarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including fumarate." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown to fumarate" EXACT [] synonym: "glutamate degradation to fumarate" EXACT [] is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019461 name: glutamate catabolic process to fumarate, using glutamate synthase (NADPH) namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown into fumarate of glutamate, catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:jl] subset: gosubset_prok synonym: "glutamate breakdown to fumarate, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamate degradation to fumarate, using glutamate synthase (NADPH)" EXACT [] xref: MetaCyc:GLUTAMINEFUM-PWY is_a: GO:0019460 ! glutamate catabolic process to fumarate [Term] id: GO:0019462 name: glutamate catabolic process to fumarate, using glutaminase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown into fumarate of glutamate, catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:jl] subset: gosubset_prok synonym: "glutamate breakdown to fumarate, using glutaminase" EXACT [] synonym: "glutamate degradation to fumarate, using glutaminase" EXACT [] is_a: GO:0019460 ! glutamate catabolic process to fumarate [Term] id: GO:0019463 name: glycine catabolic process to creatine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine." [GOC:go_curators] subset: gosubset_prok synonym: "glycine breakdown to creatine" EXACT [] synonym: "glycine degradation to creatine" EXACT [] xref: MetaCyc:GLYCGREAT-PWY is_a: GO:0006546 ! glycine catabolic process is_a: GO:0006600 ! creatine metabolic process [Term] id: GO:0019464 name: glycine decarboxylation via glycine cleavage system namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY] subset: gosubset_prok synonym: "glycine cleavage system" BROAD [] xref: MetaCyc:GLYCLEAV-PWY is_a: GO:0006546 ! glycine catabolic process [Term] id: GO:0019465 name: aspartate transamidation namespace: biological_process def: "The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: MetaCyc:ASPARTATE-DEG1-PWY xref: MetaCyc:ASPARTATESYN-PWY is_a: GO:0006533 ! aspartate catabolic process [Term] id: GO:0019466 name: ornithine catabolic process via proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline." [GOC:go_curators] subset: gosubset_prok synonym: "ornithine breakdown via proline" EXACT [] synonym: "ornithine degradation via proline" EXACT [] xref: MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY is_a: GO:0006560 ! proline metabolic process is_a: GO:0006593 ! ornithine catabolic process [Term] id: GO:0019467 name: ornithine catabolic process, by decarboxylation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation." [GOC:go_curators] subset: gosubset_prok synonym: "ornithine breakdown, by decarboxylation" EXACT [] synonym: "ornithine degradation, by decarboxylation" EXACT [] xref: MetaCyc:ORNDEG-PWY is_a: GO:0006593 ! ornithine catabolic process [Term] id: GO:0019468 name: nopaline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nopaline breakdown" EXACT [] synonym: "nopaline catabolism" EXACT [] synonym: "nopaline degradation" EXACT [] xref: MetaCyc:NOPALINEDEG-PWY is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046418 ! nopaline metabolic process [Term] id: GO:0019469 name: octopine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "octopine breakdown" EXACT [] synonym: "octopine catabolism" EXACT [] synonym: "octopine degradation" EXACT [] xref: MetaCyc:OCTOPINEDEG-PWY is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046419 ! octopine metabolic process [Term] id: GO:0019470 name: 4-hydroxyproline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] subset: gosubset_prok synonym: "4-hydroxyproline breakdown" EXACT [] synonym: "4-hydroxyproline catabolism" EXACT [] synonym: "4-hydroxyproline degradation" EXACT [] xref: MetaCyc:HYDROXYPRODEG-PWY is_a: GO:0019471 ! 4-hydroxyproline metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019471 name: 4-hydroxyproline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls." [CHEBI:20392, GOC:ai] subset: gosubset_prok synonym: "4-hydroxyproline metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0019472 name: 4-hydroxyproline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] subset: gosubset_prok synonym: "4-hydroxyproline anabolism" EXACT [] synonym: "4-hydroxyproline biosynthesis" EXACT [] synonym: "4-hydroxyproline formation" EXACT [] synonym: "4-hydroxyproline synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019471 ! 4-hydroxyproline metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0019473 name: L-lysine catabolic process to glutarate, by acetylation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation." [GOC:go_curators] subset: gosubset_prok synonym: "L-lysine breakdown to glutarate, by acetylation" EXACT [] synonym: "L-lysine degradation to glutarate, by acetylation" EXACT [] xref: MetaCyc:LYSDEGII-PWY is_a: GO:0019477 ! L-lysine catabolic process [Term] id: GO:0019474 name: L-lysine catabolic process to acetyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA." [GOC:go_curators] subset: gosubset_prok synonym: "L-lysine breakdown to acetyl-CoA" EXACT [] synonym: "L-lysine degradation to acetyl-CoA" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0019477 ! L-lysine catabolic process [Term] id: GO:0019475 name: L-lysine catabolic process to acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate." [GOC:go_curators] subset: gosubset_prok synonym: "L-lysine breakdown to acetate" EXACT [] synonym: "L-lysine degradation to acetate" EXACT [] synonym: "lysine fermentation" EXACT [] xref: MetaCyc:P163-PWY is_a: GO:0006083 ! acetate metabolic process is_a: GO:0019477 ! L-lysine catabolic process is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019476 name: D-lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [CHEBI:16855, GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-lysine breakdown" EXACT [] synonym: "D-lysine catabolism" EXACT [] synonym: "D-lysine degradation" EXACT [] is_a: GO:0006554 ! lysine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0046441 ! D-lysine metabolic process [Term] id: GO:0019477 name: L-lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-lysine breakdown" EXACT [] synonym: "L-lysine catabolism" EXACT [] synonym: "L-lysine degradation" EXACT [] is_a: GO:0006554 ! lysine catabolic process is_a: GO:0046440 ! L-lysine metabolic process [Term] id: GO:0019478 name: D-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "D-amino acid breakdown" EXACT [] synonym: "D-amino acid catabolism" EXACT [] synonym: "D-amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0019479 name: L-alanine oxidation to D-lactate and ammonia namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia." [MetaCyc:ALACAT2-PWY] subset: gosubset_prok xref: MetaCyc:ALACAT2-PWY is_a: GO:0042853 ! L-alanine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019480 name: L-alanine oxidation to pyruvate via D-alanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate." [MetaCyc:ALADEG-PWY] subset: gosubset_prok xref: MetaCyc:ALADEG-PWY is_a: GO:0042853 ! L-alanine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019481 name: L-alanine catabolic process, by transamination namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination." [GOC:go_curators] subset: gosubset_prok synonym: "L-alanine breakdown, by transamination" EXACT [] synonym: "L-alanine degradation, by transamination" EXACT [] xref: MetaCyc:ALANINE-DEG3-PWY is_a: GO:0042853 ! L-alanine catabolic process [Term] id: GO:0019482 name: beta-alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-alanine metabolism" EXACT [] xref: Wikipedia:Beta-alanine is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0019483 name: beta-alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-alanine anabolism" EXACT [] synonym: "beta-alanine biosynthesis" EXACT [] synonym: "beta-alanine formation" EXACT [] synonym: "beta-alanine synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0019482 ! beta-alanine metabolic process [Term] id: GO:0019484 name: beta-alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-alanine breakdown" EXACT [] synonym: "beta-alanine catabolism" EXACT [] synonym: "beta-alanine degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0019482 ! beta-alanine metabolic process [Term] id: GO:0019485 name: beta-alanine catabolic process to L-alanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine." [GOC:go_curators] subset: gosubset_prok synonym: "beta-alanine breakdown to L-alanine" EXACT [] synonym: "beta-alanine degradation to L-alanine" EXACT [] is_a: GO:0019484 ! beta-alanine catabolic process is_a: GO:0042851 ! L-alanine metabolic process [Term] id: GO:0019486 name: beta-alanine catabolic process to mevalonate semialdehyde, by transamination namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination." [GOC:go_curators] subset: gosubset_prok synonym: "beta-alanine breakdown to mevalonate semialdehyde, by transamination" EXACT [] synonym: "beta-alanine degradation to mevalonate semialdehyde, by transamination" EXACT [] xref: MetaCyc:BETA-ALA-DEGRADATION-I-PWY is_a: GO:0019484 ! beta-alanine catabolic process [Term] id: GO:0019487 name: anaerobic acetylene catabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "anaerobic acetylene breakdown" EXACT [] synonym: "anaerobic acetylene catabolism" EXACT [] synonym: "anaerobic acetylene degradation" EXACT [] synonym: "anaerobic ethyne catabolic process" EXACT [] synonym: "anaerobic ethyne catabolism" EXACT [] xref: MetaCyc:P161-PWY is_a: GO:0018864 ! acetylene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043454 ! alkyne catabolic process [Term] id: GO:0019488 name: ribitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate." [MetaCyc:RIBITOLUTIL-PWY] subset: gosubset_prok synonym: "ribitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "ribitol degradation to xylulose 5-phosphate" EXACT [] synonym: "ribitol utilization" RELATED [] xref: MetaCyc:RIBITOLUTIL-PWY is_a: GO:0046363 ! ribitol catabolic process is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019489 name: methylgallate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] subset: gosubset_prok synonym: "methylgallate metabolism" EXACT [] is_a: GO:0018918 ! gallate metabolic process [Term] id: GO:0019490 name: 2-aminobenzenesulfonate desulfonation namespace: biological_process def: "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [http://umbbd.ahc.umn.edu/abs/abs_map.html, UM-BBD_pathwayID:abs] subset: gosubset_prok synonym: "2-aminobenzenesulphonate desulphonation" EXACT [] xref: MetaCyc:2ASDEG-PWY is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process [Term] id: GO:0019491 name: ectoine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] subset: gosubset_prok synonym: "ectoine anabolism" EXACT [] synonym: "ectoine biosynthesis" EXACT [] synonym: "ectoine formation" EXACT [] synonym: "ectoine synthesis" EXACT [] xref: MetaCyc:P101-PWY is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042399 ! ectoine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0019492 name: proline salvage namespace: biological_process def: "Any process which produces the amino acid proline from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "proline cycling" EXACT [] is_a: GO:0006561 ! proline biosynthetic process is_a: GO:0043102 ! amino acid salvage [Term] id: GO:0019493 name: arginine catabolic process to proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline." [GOC:go_curators] subset: gosubset_prok synonym: "arginine breakdown to proline" EXACT [] synonym: "arginine degradation to proline" EXACT [] xref: MetaCyc:ARG-PRO-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006560 ! proline metabolic process [Term] id: GO:0019495 name: proline catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate." [GOC:go_curators] subset: gosubset_prok synonym: "proline breakdown to 2-oxoglutarate" EXACT [] synonym: "proline catabolic process to 2-ketoglutarate" EXACT [] synonym: "proline catabolic process to alpha-ketoglutarate" EXACT [] synonym: "proline catabolic process to alpha-oxoglutarate" EXACT [] synonym: "proline catabolism to 2-ketoglutarate" EXACT [] synonym: "proline catabolism to alpha-ketoglutarate" EXACT [] synonym: "proline catabolism to alpha-oxoglutarate" EXACT [] synonym: "proline degradation to 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006562 ! proline catabolic process [Term] id: GO:0019496 name: serine-isocitrate lyase pathway namespace: biological_process def: "A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide." [ISBN:0387961534] subset: gosubset_prok is_a: GO:0006730 ! one-carbon metabolic process [Term] id: GO:0019497 name: hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution." [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch] subset: gosubset_prok synonym: "hexachlorocyclohexane metabolism" EXACT [] is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0019498 name: n-octane oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA." [MetaCyc:P221-PWY] subset: gosubset_prok xref: MetaCyc:P221-PWY is_a: GO:0018939 ! n-octane metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019499 name: cyanide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyanide metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019500 name: cyanide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyanide breakdown" EXACT [] synonym: "cyanide catabolism" EXACT [] synonym: "cyanide degradation" EXACT [] xref: MetaCyc:P401-PWY is_a: GO:0019499 ! cyanide metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0019501 name: arsonoacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom." [GOC:jl] subset: gosubset_prok synonym: "arsonoacetate breakdown" EXACT [] synonym: "arsonoacetate catabolism" EXACT [] synonym: "arsonoacetate degradation" EXACT [] xref: MetaCyc:P482-PWY is_a: GO:0018872 ! arsonoacetate metabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0019502 name: stachydrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants." [GOC:curators, MetaCyc:CPD-821] subset: gosubset_prok synonym: "stachydrine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006577 ! betaine metabolic process [Term] id: GO:0019503 name: stachydrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] subset: gosubset_prok synonym: "stachydrine anabolism" EXACT [] synonym: "stachydrine biosynthesis" EXACT [] synonym: "stachydrine formation" EXACT [] synonym: "stachydrine synthesis" EXACT [] is_a: GO:0006578 ! betaine biosynthetic process is_a: GO:0019502 ! stachydrine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0019504 name: stachydrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] subset: gosubset_prok synonym: "stachydrine breakdown" EXACT [] synonym: "stachydrine catabolism" EXACT [] synonym: "stachydrine degradation" EXACT [] xref: MetaCyc:P561-PWY is_a: GO:0006579 ! betaine catabolic process is_a: GO:0019502 ! stachydrine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process [Term] id: GO:0019505 name: resorcinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic." [GOC:jl, http://www.speclab.com/compound/c108463.htm] subset: gosubset_prok synonym: "1,3-benzenediol metabolic process" EXACT [] synonym: "1,3-benzenediol metabolism" EXACT [] synonym: "1,3-dihydroxybenzene metabolic process" EXACT [] synonym: "1,3-dihydroxybenzene metabolism" EXACT [] synonym: "resorcinol metabolism" EXACT [] xref: MetaCyc:P343-PWY is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0034311 ! diol metabolic process [Term] id: GO:0019506 name: phenylmercury acetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai] subset: gosubset_prok synonym: "phenylmercury acetate breakdown" EXACT [] synonym: "phenylmercury acetate catabolism" EXACT [] synonym: "phenylmercury acetate degradation" EXACT [] xref: MetaCyc:P641-PWY is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046412 ! phenylmercury acetate metabolic process is_a: GO:0046413 ! organomercury catabolic process [Term] id: GO:0019507 name: pyridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [CHEBI:16227, GOC:curators] subset: gosubset_prok synonym: "pyridine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0019508 name: 2,5-dihydroxypyridine catabolic process to fumarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate." [MetaCyc:PWY-722] subset: gosubset_prok synonym: "2,5-dihydroxypyridine breakdown to fumarate" EXACT [] synonym: "2,5-dihydroxypyridine degradation to fumarate" EXACT [] synonym: "2,5-dihydroxypyridine utilization" RELATED [] synonym: "maleamate pathway" EXACT [] synonym: "pyridine-2,5-diol catabolic process to fumarate" EXACT [CHEBI:16364] xref: MetaCyc:PWY-722 is_a: GO:0051166 ! 2,5-dihydroxypyridine catabolic process [Term] id: GO:0019509 name: L-methionine salvage from methylthioadenosine namespace: biological_process def: "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361] subset: gosubset_prok synonym: "methionine recycling" NARROW [] synonym: "methionine regeneration" NARROW [] synonym: "methionine salvage from methylthioadenosine" EXACT [GOC:mah] synonym: "methionine salvage pathway" EXACT [] xref: MetaCyc:PWY-4361 is_a: GO:0043102 ! amino acid salvage is_a: GO:0071267 ! L-methionine salvage [Term] id: GO:0019510 name: S-adenosylhomocysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "S-adenosylhomocysteine breakdown" EXACT [] synonym: "S-adenosylhomocysteine catabolism" EXACT [] synonym: "S-adenosylhomocysteine degradation" EXACT [] xref: MetaCyc:ADENOSYLHOMOCYSCAT-PWY is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process [Term] id: GO:0019511 name: peptidyl-proline hydroxylation namespace: biological_process alt_id: GO:0006472 def: "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah] subset: gosubset_prok is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0019512 name: lactose catabolic process via tagatose-6-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate." [GOC:go_curators] subset: gosubset_prok synonym: "lactose breakdown via tagatose-6-phosphate" EXACT [] synonym: "lactose degradation via tagatose-6-phosphate" EXACT [] xref: MetaCyc:LACTOSECAT-PWY is_a: GO:0005990 ! lactose catabolic process [Term] id: GO:0019513 name: lactose catabolic process, using glucoside 3-dehydrogenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13)." [GOC:jl] subset: gosubset_prok synonym: "lactose breakdown, using glucoside 3-dehydrogenase" EXACT [] synonym: "lactose degradation, using glucoside 3-dehydrogenase" EXACT [] xref: MetaCyc:LACTOSEUTIL-PWY is_a: GO:0005990 ! lactose catabolic process [Term] id: GO:0019514 name: lactose hydrolysis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because hydrolysis is a reaction. is_obsolete: true consider: GO:0004565 [Term] id: GO:0019515 name: lactose catabolic process via UDP-galactose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose." [GOC:go_curators] subset: gosubset_prok synonym: "lactose breakdown via UDP-galactose" EXACT [] synonym: "lactose degradation via UDP-galactose" EXACT [] is_a: GO:0005990 ! lactose catabolic process [Term] id: GO:0019516 name: lactate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons." [GOC:mah] subset: gosubset_prok is_a: GO:0006089 ! lactate metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019517 name: threonine catabolic process to D-lactate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate." [GOC:jl, MetaCyc:THRDLCTCAT-PWY] subset: gosubset_prok synonym: "threonine breakdown to D-lactate" EXACT [] synonym: "threonine catabolic process to methylglyoxal" EXACT [MetaCyc:THRDLCTCAT-PWY] synonym: "threonine catabolic process to pyruvate" RELATED [GOC:mah] synonym: "threonine catabolism to D-lactate" EXACT [GOC:mah] synonym: "threonine degradation to D-lactate" EXACT [] xref: MetaCyc:THRDLCTCAT-PWY is_a: GO:0006089 ! lactate metabolic process is_a: GO:0006567 ! threonine catabolic process [Term] id: GO:0019518 name: threonine catabolic process to glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound glycine." [GOC:mah, MetaCyc:THREONINE-DEG2-PWY] subset: gosubset_prok synonym: "threonine breakdown to glycine" EXACT [GOC:mah] synonym: "threonine catabolic process to pyruvate" RELATED [GOC:mah] synonym: "threonine catabolism to glycine" EXACT [GOC:mah] synonym: "threonine degradation to glycine" EXACT [GOC:mah] xref: MetaCyc:THREONINE-DEG2-PWY is_a: GO:0006567 ! threonine catabolic process [Term] id: GO:0019519 name: pentitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentitol metabolism" EXACT [] is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0019520 name: aldonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aldonic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0019521 name: D-gluconate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-gluconate metabolism" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019522 name: ketogluconate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ketogluconate metabolism" EXACT [] xref: MetaCyc:KETOGLUCONMET-PWY is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019523 name: L-idonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [CHEBI:17796, GOC:ai] subset: gosubset_prok synonym: "L-idonate metabolism" EXACT [] xref: MetaCyc:IDNCAT-PWY is_a: GO:0019522 ! ketogluconate metabolic process [Term] id: GO:0019524 name: D-dehydro-D-gluconate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-dehydro-D-gluconate breakdown" EXACT [] synonym: "D-dehydro-D-gluconate catabolism" EXACT [] synonym: "D-dehydro-D-gluconate degradation" EXACT [] xref: MetaCyc:DHGLUCONATE-PYR-CAT-PWY is_a: GO:0019525 ! D-dehydro-D-gluconate metabolic process is_a: GO:0046176 ! aldonic acid catabolic process [Term] id: GO:0019525 name: D-dehydro-D-gluconate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-dehydro-D-gluconate metabolism" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019526 name: pentitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentitol anabolism" EXACT [] synonym: "pentitol biosynthesis" EXACT [] synonym: "pentitol formation" EXACT [] synonym: "pentitol synthesis" EXACT [] is_a: GO:0019401 ! alditol biosynthetic process is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0019527 name: pentitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentitol breakdown" EXACT [] synonym: "pentitol catabolism" EXACT [] synonym: "pentitol degradation" EXACT [] is_a: GO:0019405 ! alditol catabolic process is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0019528 name: D-arabitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate." [MetaCyc:DARABITOLUTIL-PWY] subset: gosubset_prok synonym: "D-arabitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "D-arabitol degradation" RELATED [] synonym: "D-arabitol degradation to xylulose 5-phosphate" EXACT [] synonym: "D-arabitol utilization" RELATED [] xref: MetaCyc:DARABITOLUTIL-PWY is_a: GO:0051159 ! D-arabitol catabolic process is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019529 name: taurine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] subset: gosubset_prok synonym: "taurine breakdown" EXACT [] synonym: "taurine catabolism" EXACT [] synonym: "taurine degradation" EXACT [] xref: MetaCyc:TAURINEDEG-PWY is_a: GO:0009310 ! amine catabolic process is_a: GO:0019530 ! taurine metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0019530 name: taurine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] subset: gosubset_prok synonym: "taurine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0019531 name: oxalate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oxalic acid transporter activity" EXACT [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0019532 name: oxalate transport namespace: biological_process def: "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ethanedioate transport" EXACT [] synonym: "ethanedioic acid transport" EXACT [] synonym: "oxalic acid transport" EXACT [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015711 ! organic anion transport [Term] id: GO:0019533 name: cellobiose transport namespace: biological_process def: "The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:ai] subset: gosubset_prok is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0019534 name: toxin transporter activity namespace: molecular_function def: "Enables the directed movement of a toxin into, out of or within a cell, or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0005215 ! transporter activity [Term] id: GO:0019535 name: ferric-vibriobactin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ferric-vibriobactin ions from one side of a membrane to the other." [GOC:ai] is_a: GO:0015343 ! siderophore transmembrane transporter activity [Term] id: GO:0019536 name: vibriobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] subset: gosubset_prok synonym: "vibriobactin metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0019537 name: vibriobactin biosynthetic process namespace: biological_process alt_id: GO:0031195 alt_id: GO:0031196 def: "The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] subset: gosubset_prok synonym: "vibriobactin anabolism" EXACT [] synonym: "vibriobactin biosynthesis" EXACT [] synonym: "vibriobactin biosynthetic process, peptide formation" NARROW [] synonym: "vibriobactin biosynthetic process, peptide modification" NARROW [] synonym: "vibriobactin formation" EXACT [] synonym: "vibriobactin synthesis" EXACT [] is_a: GO:0019536 ! vibriobactin metabolic process is_a: GO:0019540 ! siderophore biosynthetic process from catechol [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process [Term] id: GO:0019539 name: siderophore biosynthetic process from hydroxamic acid namespace: biological_process alt_id: GO:0031197 alt_id: GO:0031198 def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid." [GOC:go_curators] subset: gosubset_prok synonym: "siderochrome biosynthesis from hydroxamic acid" NARROW [] synonym: "siderochrome biosynthetic process from hydroxamic acid" NARROW [] synonym: "siderophore anabolism from hydroxamic acid" EXACT [] synonym: "siderophore biosynthetic process from hydroxamic acid, peptide formation" NARROW [] synonym: "siderophore biosynthetic process from hydroxamic acid, peptide modification" NARROW [] synonym: "siderophore formation from hydroxamic acid" EXACT [] synonym: "siderophore synthesis from hydroxamic acid" EXACT [] is_a: GO:0019290 ! siderophore biosynthetic process [Term] id: GO:0019540 name: siderophore biosynthetic process from catechol namespace: biological_process alt_id: GO:0031189 alt_id: GO:0031190 def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol." [GOC:go_curators] subset: gosubset_prok synonym: "siderochrome biosynthesis from catechol" NARROW [] synonym: "siderochrome biosynthetic process from catechol" NARROW [] synonym: "siderophore anabolism from catechol" EXACT [] synonym: "siderophore biosynthetic process from catechol, peptide formation" NARROW [] synonym: "siderophore biosynthetic process from catechol, peptide modification" NARROW [] synonym: "siderophore formation from catechol" EXACT [] synonym: "siderophore synthesis from catechol" EXACT [] is_a: GO:0009712 ! catechol metabolic process is_a: GO:0019290 ! siderophore biosynthetic process [Term] id: GO:0019541 name: propionate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", KEGG:C00163, MetaCyc:PROPIONATE] subset: gosubset_prok synonym: "propanoate metabolic process" EXACT [] synonym: "propanoate metabolism" EXACT [] synonym: "propionate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019542 name: propionate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid." [GOC:go_curators] subset: gosubset_prok synonym: "propionate anabolism" EXACT [] synonym: "propionate biosynthesis" EXACT [] synonym: "propionate formation" EXACT [] synonym: "propionate synthesis" EXACT [] is_a: GO:0019541 ! propionate metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0019543 name: propionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid." [GOC:go_curators] subset: gosubset_prok synonym: "propionate breakdown" EXACT [] synonym: "propionate catabolism" EXACT [] synonym: "propionate degradation" EXACT [] is_a: GO:0019541 ! propionate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019544 name: arginine catabolic process to glutamate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate." [GOC:go_curators] subset: gosubset_prok synonym: "arginine breakdown to glutamate" EXACT [] synonym: "arginine degradation to glutamate" EXACT [] xref: MetaCyc:ARG-GLU-PWY xref: MetaCyc:ARGASEDEG-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006536 ! glutamate metabolic process [Term] id: GO:0019545 name: arginine catabolic process to succinate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate." [GOC:go_curators] subset: gosubset_prok synonym: "arginine breakdown to succinate" EXACT [] synonym: "arginine degradation to succinate" EXACT [] xref: MetaCyc:ARGDEG-III-PWY xref: MetaCyc:ARGDEG-IV-PWY xref: MetaCyc:ARGDEG-V-PWY xref: MetaCyc:AST-PWY is_a: GO:0006105 ! succinate metabolic process is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0019546 name: arginine deiminase pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase." [GOC:mah, MetaCyc:ARGDEGRAD-PWY] subset: gosubset_prok xref: MetaCyc:ARGDEGRAD-PWY is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0019547 name: arginine catabolic process to ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine." [GOC:go_curators] subset: gosubset_prok synonym: "arginine breakdown to ornithine" EXACT [] synonym: "arginine degradation to ornithine" EXACT [] is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006591 ! ornithine metabolic process [Term] id: GO:0019548 name: arginine catabolic process to spermine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine." [GOC:go_curators] subset: gosubset_prok synonym: "arginine breakdown to spermine" EXACT [] synonym: "arginine degradation to spermine" EXACT [] xref: MetaCyc:ARGSPECAT-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0008215 ! spermine metabolic process [Term] id: GO:0019549 name: glutamate catabolic process to succinate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including succinate." [GOC:go_curators, MetaCyc:PWY-4321] subset: gosubset_prok synonym: "glutamate breakdown to succinate" EXACT [] synonym: "glutamate degradation to succinate" EXACT [] xref: MetaCyc:PWY-4321 is_a: GO:0006105 ! succinate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019550 name: glutamate catabolic process to aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown to aspartate" EXACT [] synonym: "glutamate degradation to aspartate" EXACT [] xref: MetaCyc:GLUTDEG-PWY is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019551 name: glutamate catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown to 2-oxoglutarate" EXACT [] synonym: "glutamate catabolic process to 2-ketoglutarate" EXACT [] synonym: "glutamate catabolic process to alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolic process to alpha-oxoglutarate" EXACT [] synonym: "glutamate catabolism to 2-ketoglutarate" EXACT [] synonym: "glutamate catabolism to alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolism to alpha-oxoglutarate" EXACT [] synonym: "glutamate degradation to 2-oxoglutarate" EXACT [] xref: MetaCyc:GLUTAMATE-DEG1-PWY is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019552 name: glutamate catabolic process via 2-hydroxyglutarate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP." [MetaCyc:P162-PWY] subset: gosubset_prok synonym: "glutamate fermentation via 2-hydroxyglutarate" EXACT [] xref: MetaCyc:P162-PWY is_a: GO:0019670 ! anaerobic glutamate catabolic process [Term] id: GO:0019553 name: glutamate catabolic process via L-citramalate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown via L-citramalate" EXACT [] synonym: "glutamate degradation via L-citramalate" EXACT [] xref: MetaCyc:GLUDEG-II-PWY is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019554 name: glutamate catabolic process to oxaloacetate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown to oxaloacetate" EXACT [] synonym: "glutamate degradation to oxaloacetate" EXACT [] is_a: GO:0006107 ! oxaloacetate metabolic process is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019555 name: glutamate catabolic process to ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown to ornithine" EXACT [] synonym: "glutamate degradation to ornithine" EXACT [] xref: MetaCyc:GLUTORN-PWY is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0006591 ! ornithine metabolic process [Term] id: GO:0019556 name: histidine catabolic process to glutamate and formamide namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide." [GOC:go_curators] subset: gosubset_prok synonym: "histidine breakdown to glutamate and formamide" EXACT [] synonym: "histidine degradation to glutamate and formamide" EXACT [] xref: MetaCyc:HISDEG-PWY is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006548 ! histidine catabolic process [Term] id: GO:0019557 name: histidine catabolic process to glutamate and formate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate." [GOC:go_curators] subset: gosubset_prok synonym: "histidine breakdown to glutamate and formate" EXACT [] synonym: "histidine degradation to glutamate and formate" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006548 ! histidine catabolic process is_a: GO:0015942 ! formate metabolic process [Term] id: GO:0019558 name: histidine catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate." [GOC:go_curators] subset: gosubset_prok synonym: "histidine breakdown to 2-oxoglutarate" EXACT [] synonym: "histidine catabolic process to 2-ketoglutarate" EXACT [] synonym: "histidine catabolic process to alpha-ketoglutarate" EXACT [] synonym: "histidine catabolic process to alpha-oxoglutarate" EXACT [] synonym: "histidine catabolism to 2-ketoglutarate" EXACT [] synonym: "histidine catabolism to alpha-ketoglutarate" EXACT [] synonym: "histidine catabolism to alpha-oxoglutarate" EXACT [] synonym: "histidine degradation to 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006548 ! histidine catabolic process [Term] id: GO:0019559 name: histidine catabolic process to imidazol-5-yl-lactate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate." [GOC:go_curators] subset: gosubset_prok synonym: "histidine breakdown to imidazol-5-yl-lactate" EXACT [] synonym: "histidine degradation to imidazol-5-yl-lactate" EXACT [] xref: MetaCyc:HISTDEG-PWY is_a: GO:0006548 ! histidine catabolic process [Term] id: GO:0019560 name: histidine catabolic process to hydantoin-5-propionate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate." [GOC:go_curators] subset: gosubset_prok synonym: "histidine breakdown to hydantoin-5-propionate" EXACT [] synonym: "histidine degradation to hydantoin-5-propionate" EXACT [] xref: MetaCyc:HISHP-PWY is_a: GO:0006548 ! histidine catabolic process [Term] id: GO:0019561 name: anaerobic phenylalanine oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde." [GOC:mah, MetaCyc:ANAPHENOXI-PWY] subset: gosubset_prok xref: MetaCyc:ANAPHENOXI-PWY is_a: GO:0006559 ! L-phenylalanine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019562 name: phenylalanine catabolic process to phosphoenolpyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] subset: gosubset_prok synonym: "phenylalanine breakdown to phosphoenolpyruvate" EXACT [] synonym: "phenylalanine degradation to phosphoenolpyruvate" EXACT [] xref: MetaCyc:PHENYLALANINE-DEG1-PWY is_a: GO:0006559 ! L-phenylalanine catabolic process [Term] id: GO:0019563 name: glycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerol breakdown" EXACT [] synonym: "glycerol catabolism" EXACT [] synonym: "glycerol degradation" EXACT [] xref: MetaCyc:PWY-4261 xref: MetaCyc:PWY0-381 is_a: GO:0006071 ! glycerol metabolic process is_a: GO:0019405 ! alditol catabolic process [Term] id: GO:0019564 name: aerobic glycerol catabolic process namespace: biological_process alt_id: GO:0019565 def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aerobic glycerol breakdown" EXACT [] synonym: "aerobic glycerol catabolism" EXACT [] synonym: "aerobic glycerol degradation" EXACT [] synonym: "aerobic glycerol fermentation" RELATED [] xref: MetaCyc:PWY0-381 is_a: GO:0019563 ! glycerol catabolic process [Term] id: GO:0019566 name: arabinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "arabinose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0019567 name: arabinose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose." [GOC:ai] subset: gosubset_prok synonym: "arabinose anabolism" EXACT [] synonym: "arabinose biosynthesis" EXACT [] synonym: "arabinose formation" EXACT [] synonym: "arabinose synthesis" EXACT [] is_a: GO:0019322 ! pentose biosynthetic process is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0019568 name: arabinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose." [GOC:ai] subset: gosubset_prok synonym: "arabinose breakdown" EXACT [] synonym: "arabinose catabolism" EXACT [] synonym: "arabinose degradation" EXACT [] is_a: GO:0019323 ! pentose catabolic process is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0019569 name: L-arabinose catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate." [GOC:go_curators] subset: gosubset_prok synonym: "L-arabinose breakdown to xylulose 5-phosphate" EXACT [] synonym: "L-arabinose degradation to xylulose 5-phosphate" EXACT [] xref: MetaCyc:ARABCAT-PWY is_a: GO:0019572 ! L-arabinose catabolic process is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019570 name: L-arabinose catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate." [GOC:go_curators] subset: gosubset_prok synonym: "L-arabinose breakdown to 2-oxoglutarate" EXACT [] synonym: "L-arabinose catabolic process to 2-ketoglutarate" EXACT [] synonym: "L-arabinose catabolic process to alpha-ketoglutarate" EXACT [] synonym: "L-arabinose catabolic process to alpha-oxoglutarate" EXACT [] synonym: "L-arabinose catabolism to 2-ketoglutarate" EXACT [] synonym: "L-arabinose catabolism to alpha-ketoglutarate" EXACT [] synonym: "L-arabinose catabolism to alpha-oxoglutarate" EXACT [] synonym: "L-arabinose degradation to 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0019572 ! L-arabinose catabolic process [Term] id: GO:0019571 name: D-arabinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose." [CHEBI:17108, GOC:go_curators, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-arabinose breakdown" EXACT [] synonym: "D-arabinose catabolism" EXACT [] synonym: "D-arabinose degradation" EXACT [] is_a: GO:0019568 ! arabinose catabolic process is_a: GO:0046372 ! D-arabinose metabolic process [Term] id: GO:0019572 name: L-arabinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose." [CHEBI:30849, GOC:go_curators, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-arabinose breakdown" EXACT [] synonym: "L-arabinose catabolism" EXACT [] synonym: "L-arabinose degradation" EXACT [] is_a: GO:0019568 ! arabinose catabolic process is_a: GO:0046373 ! L-arabinose metabolic process [Term] id: GO:0019573 name: D-arabinose catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate." [GOC:go_curators] subset: gosubset_prok synonym: "D-arabinose breakdown to xylulose 5-phosphate" EXACT [] synonym: "D-arabinose degradation to xylulose 5-phosphate" EXACT [] xref: MetaCyc:DARABCAT-PWY is_a: GO:0019571 ! D-arabinose catabolic process is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019574 name: sucrose catabolic process, using glucoside 3-dehydrogenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13)." [GOC:jl] subset: gosubset_prok synonym: "sucrose breakdown, using glucoside 3-dehydrogenase" EXACT [] synonym: "sucrose catabolism, using glucoside 3-dehydrogenase" EXACT [] synonym: "sucrose degradation, using glucoside 3-dehydrogenase" EXACT [] xref: MetaCyc:SUCROSEUTIL2-PWY is_a: GO:0005987 ! sucrose catabolic process [Term] id: GO:0019575 name: sucrose catabolic process, using beta-fructofuranosidase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26)." [GOC:jl] subset: gosubset_prok synonym: "sucrose breakdown, using beta-fructofuranosidase" EXACT [] synonym: "sucrose catabolism, using beta-fructofuranosidase" EXACT [] synonym: "sucrose degradation, using beta-fructofuranosidase" EXACT [] xref: MetaCyc:SUCUTIL-PWY is_a: GO:0005987 ! sucrose catabolic process [Term] id: GO:0019576 name: aerobic fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "aerobic fructose breakdown" EXACT [] synonym: "aerobic fructose catabolism" EXACT [] synonym: "aerobic fructose degradation" EXACT [] is_a: GO:0006001 ! fructose catabolic process [Term] id: GO:0019577 name: aldaric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aldaric acid metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0019578 name: aldaric acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aldaric acid anabolism" EXACT [] synonym: "aldaric acid biosynthesis" EXACT [] synonym: "aldaric acid formation" EXACT [] synonym: "aldaric acid synthesis" EXACT [] is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0019577 ! aldaric acid metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019579 name: aldaric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aldaric acid breakdown" EXACT [] synonym: "aldaric acid catabolism" EXACT [] synonym: "aldaric acid degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0019577 ! aldaric acid metabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0019580 name: galactarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactarate metabolism" EXACT [] synonym: "mucic acid metabolic process" EXACT [] synonym: "mucic acid metabolism" EXACT [] is_a: GO:0019577 ! aldaric acid metabolic process [Term] id: GO:0019582 name: D-galactarate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-galactarate, the D-enantiomer of the anion of galactaric acid." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-galactarate breakdown" EXACT [] synonym: "D-galactarate catabolism" EXACT [] synonym: "D-galactarate degradation" EXACT [] xref: MetaCyc:GALACTARDEG-PWY is_a: GO:0046392 ! galactarate catabolic process is_a: GO:0046393 ! D-galactarate metabolic process [Term] id: GO:0019583 name: galactonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose." [GOC:ai] subset: gosubset_prok synonym: "galactonate metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0019584 name: galactonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid." [GOC:ai] subset: gosubset_prok synonym: "galactonate breakdown" EXACT [] synonym: "galactonate catabolism" EXACT [] synonym: "galactonate degradation" EXACT [] xref: MetaCyc:GALACTCAT-PWY is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0019583 ! galactonate metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0019585 name: glucuronate metabolic process namespace: biological_process alt_id: GO:0019699 def: "The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucuronate metabolism" EXACT [] xref: Wikipedia:Glucuronic_acid is_a: GO:0006063 ! uronic acid metabolic process [Term] id: GO:0019586 name: galacturonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galacturonate metabolism" EXACT [] is_a: GO:0006063 ! uronic acid metabolic process [Term] id: GO:0019588 name: anaerobic glycerol catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP." [GOC:mah] subset: gosubset_prok synonym: "glycerol fermentation" EXACT [] is_a: GO:0019563 ! glycerol catabolic process is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019589 name: anaerobic glycerol catabolic process to propane-1,3-diol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water." [GOC:jl, MetaCyc:GOLPDLCAT-PWY] subset: gosubset_prok synonym: "glycerol fermentation to 1,3-propanediol" EXACT [] synonym: "glycerol fermentation to propane-1,3-diol" EXACT [] xref: MetaCyc:GOLPDLCAT-PWY is_a: GO:0019588 ! anaerobic glycerol catabolic process [Term] id: GO:0019590 name: L-arabitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] subset: gosubset_prok synonym: "L-arabitol and xylitol degradation" BROAD [] synonym: "L-arabitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "L-arabitol degradation to xylulose 5-phosphate" EXACT [] synonym: "L-arabitol utilization" RELATED [] xref: MetaCyc:LARABITOLUTIL-PWY is_a: GO:0051158 ! L-arabitol catabolic process is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019592 name: mannitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannitol breakdown" EXACT [] synonym: "mannitol catabolism" EXACT [] synonym: "mannitol degradation" EXACT [] xref: MetaCyc:MANNIDEG-PWY xref: MetaCyc:PWY-3861 is_a: GO:0019407 ! hexitol catabolic process is_a: GO:0019594 ! mannitol metabolic process [Term] id: GO:0019593 name: mannitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannitol anabolism" EXACT [] synonym: "mannitol biosynthesis" EXACT [] synonym: "mannitol formation" EXACT [] synonym: "mannitol synthesis" EXACT [] xref: MetaCyc:PWY-3881 is_a: GO:0019406 ! hexitol biosynthetic process is_a: GO:0019594 ! mannitol metabolic process [Term] id: GO:0019594 name: mannitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannitol metabolism" EXACT [] is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0019595 name: non-phosphorylated glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose." [GOC:ai] subset: gosubset_prok synonym: "non-phosphorylated glucose breakdown" EXACT [] synonym: "non-phosphorylated glucose catabolism" EXACT [] synonym: "non-phosphorylated glucose degradation" EXACT [] xref: MetaCyc:NPGLUCAT-PWY is_a: GO:0006007 ! glucose catabolic process is_a: GO:0046430 ! non-phosphorylated glucose metabolic process [Term] id: GO:0019596 name: mandelate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:go_curators] subset: gosubset_prok synonym: "mandelate breakdown" EXACT [] synonym: "mandelate catabolism" EXACT [] synonym: "mandelate degradation" EXACT [] is_a: GO:0018924 ! mandelate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process [Term] id: GO:0019597 name: (R)-mandelate catabolic process to benzoate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators] subset: gosubset_prok synonym: "(R)-mandelate breakdown to benzoate" EXACT [] synonym: "(R)-mandelate degradation to benzoate" EXACT [] is_a: GO:0018874 ! benzoate metabolic process is_a: GO:0019596 ! mandelate catabolic process [Term] id: GO:0019598 name: (R)-mandelate catabolic process to catechol namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol." [GOC:go_curators] subset: gosubset_prok synonym: "(R)-mandelate breakdown to catechol" EXACT [] synonym: "(R)-mandelate degradation to catechol" EXACT [] is_a: GO:0009712 ! catechol metabolic process is_a: GO:0019596 ! mandelate catabolic process [Term] id: GO:0019599 name: (R)-4-hydroxymandelate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid." [GOC:ai] subset: gosubset_prok synonym: "(R)-4-hydroxymandelate breakdown" EXACT [] synonym: "(R)-4-hydroxymandelate catabolism" EXACT [] synonym: "(R)-4-hydroxymandelate degradation" EXACT [] xref: MetaCyc:4-HYDROXYMANDELATE-DEGRADATION-PWY is_a: GO:0019596 ! mandelate catabolic process is_a: GO:0046431 ! (R)-4-hydroxymandelate metabolic process [Term] id: GO:0019600 name: toluene oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene." [GOC:mah] subset: gosubset_prok is_a: GO:0018970 ! toluene metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019601 name: toluene oxidation via 2-hydroxytoluene namespace: biological_process def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol)." [MetaCyc:TOLUENE-DEG-2-OH-PWY] subset: gosubset_prok xref: MetaCyc:TOLUENE-DEG-2-OH-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019602 name: toluene oxidation via 3-hydroxytoluene namespace: biological_process def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol)." [MetaCyc:TOLUENE-DEG-3-OH-PWY] subset: gosubset_prok xref: MetaCyc:TOLUENE-DEG-3-OH-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019603 name: toluene oxidation via 4-hydroxytoluene namespace: biological_process def: "The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol)." [MetaCyc:TOLUENE-DEG-4-OH-PWY] subset: gosubset_prok xref: MetaCyc:TOLUENE-DEG-4-OH-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019604 name: toluene oxidation to catechol namespace: biological_process def: "The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2)." [MetaCyc:TOLUENE-DEG-CATECHOL-PWY] subset: gosubset_prok xref: MetaCyc:TOLUENE-DEG-CATECHOL-PWY xref: UM-BBD_pathwayID:tol is_a: GO:0009712 ! catechol metabolic process is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019605 name: butyrate metabolic process namespace: biological_process alt_id: GO:0043437 def: "The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "butanoic acid metabolic process" EXACT [] synonym: "butanoic acid metabolism" EXACT [] synonym: "butyrate metabolism" EXACT [] synonym: "butyric acid metabolic process" EXACT [] synonym: "butyric acid metabolism" EXACT [] is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0019606 name: 2-oxobutyrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "2-oxobutyrate breakdown" EXACT [] synonym: "2-oxobutyrate catabolism" EXACT [] synonym: "2-oxobutyrate degradation" EXACT [] synonym: "alpha-ketobutyrate catabolic process" EXACT [] synonym: "alpha-ketobutyrate catabolism" EXACT [] xref: MetaCyc:2OXOBUTYRATECAT-PWY is_a: GO:0046359 ! butyrate catabolic process is_a: GO:0046361 ! 2-oxobutyrate metabolic process [Term] id: GO:0019607 name: phenylethylamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] synonym: "phenylethylamine breakdown" EXACT [] synonym: "phenylethylamine catabolism" EXACT [] synonym: "phenylethylamine degradation" EXACT [] xref: MetaCyc:2PHENDEG-PWY is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0042443 ! phenylethylamine metabolic process [Term] id: GO:0019608 name: nicotine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] subset: gosubset_prok synonym: "nicotine breakdown" EXACT [] synonym: "nicotine catabolism" EXACT [] synonym: "nicotine degradation" EXACT [] xref: MetaCyc:P181-PWY xref: UM-BBD_pathwayID:nic is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0018933 ! nicotine metabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0019609 name: 3-hydroxyphenylacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] subset: gosubset_prok synonym: "3-hydroxyphenylacetate metabolism" EXACT [] synonym: "3HPA metabolic process" EXACT [] synonym: "3HPA metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019610 name: 3-hydroxyphenylacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] subset: gosubset_prok synonym: "3-hydroxyphenylacetate breakdown" EXACT [] synonym: "3-hydroxyphenylacetate catabolism" EXACT [] synonym: "3-hydroxyphenylacetate degradation" EXACT [] xref: MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019609 ! 3-hydroxyphenylacetate metabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0019611 name: 4-toluenecarboxylate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] subset: gosubset_prok synonym: "4-toluenecarboxylate metabolism" EXACT [] synonym: "p-toluate metabolic process" EXACT [] synonym: "p-toluate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0019612 name: 4-toluenecarboxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] subset: gosubset_prok synonym: "4-toluenecarboxylate breakdown" EXACT [] synonym: "4-toluenecarboxylate catabolism" EXACT [] synonym: "4-toluenecarboxylate degradation" EXACT [] synonym: "p-toluate catabolic process" EXACT [] synonym: "p-toluate catabolism" EXACT [] xref: MetaCyc:4TOLCARBDEG-PWY is_a: GO:0019611 ! 4-toluenecarboxylate metabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0019614 name: catechol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol, a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] subset: gosubset_prok synonym: "catechol breakdown" EXACT [] synonym: "catechol catabolism" EXACT [] synonym: "catechol degradation" EXACT [] is_a: GO:0009712 ! catechol metabolic process is_a: GO:0034313 ! diol catabolic process [Term] id: GO:0019615 name: catechol catabolic process, ortho-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups." [GOC:jl, http://www.ence.umd.edu/] subset: gosubset_prok synonym: "catechol breakdown, ortho-cleavage" EXACT [] synonym: "catechol degradation, ortho-cleavage" EXACT [] xref: MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY is_a: GO:0019614 ! catechol catabolic process is_a: GO:0042952 ! beta-ketoadipate pathway [Term] id: GO:0019616 name: catechol catabolic process, meta-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom." [GOC:jl, http://www.ence.umd.edu/] subset: gosubset_prok synonym: "catechol breakdown, meta-cleavage" EXACT [] synonym: "catechol degradation, meta-cleavage" EXACT [] xref: MetaCyc:P183-PWY is_a: GO:0019614 ! catechol catabolic process [Term] id: GO:0019617 name: protocatechuate catabolic process, meta-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate." [MetaCyc:P184-PWY] subset: gosubset_prok synonym: "3,4-dihydroxybenzoate catabolic process, meta-cleavage" RELATED [CHEBI:36241] synonym: "protocatechuate breakdown, meta-cleavage" EXACT [] synonym: "protocatechuate degradation, meta-cleavage" EXACT [] xref: MetaCyc:P184-PWY is_a: GO:0019619 ! protocatechuate catabolic process [Term] id: GO:0019618 name: protocatechuate catabolic process, ortho-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate." [MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY] subset: gosubset_prok synonym: "3,4-dihydroxybenzoate catabolic process, ortho-cleavage" EXACT [CHEBI:36241] synonym: "protocatechuate breakdown, ortho-cleavage" EXACT [] synonym: "protocatechuate degradation, ortho-cleavage" EXACT [] xref: MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY is_a: GO:0019619 ! protocatechuate catabolic process [Term] id: GO:0019619 name: protocatechuate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid." [GOC:ai] subset: gosubset_prok synonym: "3,4-dihydroxybenzoate catabolic process" EXACT [CHEBI:36241] synonym: "protocatechuate breakdown" EXACT [] synonym: "protocatechuate catabolism" EXACT [] synonym: "protocatechuate degradation" EXACT [] is_a: GO:0019614 ! catechol catabolic process is_a: GO:0046278 ! protocatechuate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019620 name: aerobic benzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "aerobic benzoate metabolism" EXACT [] is_a: GO:0018874 ! benzoate metabolic process [Term] id: GO:0019621 name: creatinine catabolic process to formate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate." [GOC:go_curators] subset: gosubset_prok synonym: "creatinine breakdown to formate" EXACT [] synonym: "creatinine degradation to formate" EXACT [] xref: MetaCyc:CRNFORCAT-PWY is_a: GO:0006602 ! creatinine catabolic process is_a: GO:0015942 ! formate metabolic process [Term] id: GO:0019622 name: 3-(3-hydroxy)phenylpropionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai] subset: gosubset_prok synonym: "3-(3-hydroxy)phenylpropionate breakdown" EXACT [] synonym: "3-(3-hydroxy)phenylpropionate catabolism" EXACT [] synonym: "3-(3-hydroxy)phenylpropionate degradation" EXACT [] xref: MetaCyc:HCAMHPDEG-PWY is_a: GO:0019380 ! 3-phenylpropionate catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0046435 ! 3-(3-hydroxy)phenylpropionate metabolic process [Term] id: GO:0019623 name: atrazine catabolic process to urea namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea." [GOC:jl] subset: gosubset_prok synonym: "atrazine breakdown to urea" EXACT [] synonym: "atrazine degradation to urea" EXACT [] is_a: GO:0019381 ! atrazine catabolic process is_a: GO:0019627 ! urea metabolic process [Term] id: GO:0019624 name: atrazine catabolic process to isopropylamine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine." [GOC:jl] subset: gosubset_prok synonym: "atrazine breakdown to isopropylamine" EXACT [] synonym: "atrazine degradation to isopropylamine" EXACT [] is_a: GO:0019381 ! atrazine catabolic process [Term] id: GO:0019625 name: atrazine catabolic process to cyanuric acid namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid." [GOC:jl] subset: gosubset_prok synonym: "atrazine breakdown to cyanuric acid" EXACT [] synonym: "atrazine degradation to cyanuric acid" EXACT [] xref: MetaCyc:P141-PWY is_a: GO:0019381 ! atrazine catabolic process is_a: GO:0042199 ! cyanuric acid metabolic process [Term] id: GO:0019626 name: short-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "short-chain fatty acid breakdown" EXACT [] synonym: "short-chain fatty acid catabolism" EXACT [] synonym: "short-chain fatty acid degradation" EXACT [] xref: MetaCyc:ACETOACETATE-DEG-PWY is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0019627 name: urea metabolic process namespace: biological_process def: "The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "urea metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0019628 name: urate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "urate breakdown" EXACT [] synonym: "urate catabolism" EXACT [] synonym: "urate degradation" EXACT [] synonym: "uric acid catabolic process" EXACT [] xref: MetaCyc:P165-PWY is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046415 ! urate metabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0019629 name: propionate catabolic process, 2-methylcitrate cycle namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle." [GOC:go_curators] subset: gosubset_prok synonym: "propionate breakdown, 2-methylcitrate cycle" EXACT [] synonym: "propionate degradation, 2-methylcitrate cycle" EXACT [] is_a: GO:0019543 ! propionate catabolic process [Term] id: GO:0019630 name: quinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "quinate metabolism" EXACT [] synonym: "quinic acid metabolic process" EXACT [] synonym: "quinic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019631 name: quinate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid." [GOC:jl] subset: gosubset_prok synonym: "quinate breakdown" EXACT [] synonym: "quinate catabolism" EXACT [] synonym: "quinate degradation" EXACT [] synonym: "quinic acid catabolic process" EXACT [] synonym: "quinic acid catabolism" EXACT [] xref: MetaCyc:QUINATEDEG-PWY is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019630 ! quinate metabolic process [Term] id: GO:0019632 name: shikimate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids." [CHEBI:36208, GOC:sm, ISBN:0198547684] subset: gosubset_prok synonym: "shikimate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019633 name: shikimate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [CHEBI:36208, GOC:go_curators] subset: gosubset_prok synonym: "shikimate breakdown" EXACT [] synonym: "shikimate catabolism" EXACT [] synonym: "shikimate degradation" EXACT [] xref: MetaCyc:SHIKIMATEDEG-PWY is_a: GO:0019632 ! shikimate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019634 name: phosphonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "phosphonate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process [Term] id: GO:0019635 name: 2-aminoethylphosphonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine." [GOC:ai] subset: gosubset_prok synonym: "2-aminoethylphosphonate breakdown" EXACT [] synonym: "2-aminoethylphosphonate catabolism" EXACT [] synonym: "2-aminoethylphosphonate degradation" EXACT [] synonym: "2-phosphonoethylamine catabolic process" EXACT [] synonym: "2-phosphonoethylamine catabolism" EXACT [] synonym: "ciliatine catabolic process" EXACT [] synonym: "ciliatine catabolism" EXACT [] xref: MetaCyc:PHOSPHONOTASE-PWY is_a: GO:0019700 ! phosphonate catabolic process is_a: GO:0046433 ! 2-aminoethylphosphonate metabolic process [Term] id: GO:0019636 name: phosphonoacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue." [MetaCyc:P483-PWY] subset: gosubset_prok synonym: "phosphonoacetate metabolism" EXACT [] xref: MetaCyc:P483-PWY is_a: GO:0019634 ! phosphonate metabolic process [Term] id: GO:0019637 name: organophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "organophosphate metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0019638 name: 6-hydroxycineole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] subset: gosubset_prok synonym: "6-endo-hydroxycineole metabolic process" EXACT [] synonym: "6-endo-hydroxycineole metabolism" EXACT [] synonym: "6-hydroxycineole metabolism" EXACT [] synonym: "hydroxycineol metabolic process" EXACT [] synonym: "hydroxycineol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0018904 ! organic ether metabolic process [Term] id: GO:0019639 name: 6-hydroxycineole catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] subset: gosubset_prok synonym: "6-endo-hydroxycineole catabolic process" EXACT [] synonym: "6-endo-hydroxycineole catabolism" EXACT [] synonym: "6-hydroxycineole breakdown" EXACT [] synonym: "6-hydroxycineole catabolism" EXACT [] synonym: "6-hydroxycineole degradation" EXACT [] synonym: "hydroxycineol catabolic process" EXACT [] synonym: "hydroxycineol catabolism" EXACT [] xref: MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY is_a: GO:0019638 ! 6-hydroxycineole metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0019640 name: glucuronate catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate." [GOC:go_curators] subset: gosubset_prok synonym: "glucuronate breakdown to xylulose 5-phosphate" EXACT [] synonym: "glucuronate degradation to xylulose 5-phosphate" EXACT [] is_a: GO:0006064 ! glucuronate catabolic process is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019643 name: reductive tricarboxylic acid cycle namespace: biological_process alt_id: GO:0019644 def: "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate." [GOC:jl, PMID:15838028] subset: gosubset_prok synonym: "reductive carboxylate cycle" EXACT [] synonym: "reductive carboxylic acid cycle" EXACT [] synonym: "reductive citric acid pathway" EXACT [] synonym: "reductive Kreb's cycle" EXACT [] synonym: "reductive TCA cycle" EXACT [] xref: MetaCyc:P23-PWY xref: MetaCyc:REDCITCYC is_a: GO:0006099 ! tricarboxylic acid cycle is_a: GO:0015977 ! carbon fixation [Term] id: GO:0019645 name: anaerobic electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] subset: gosubset_prok is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0009061 ! anaerobic respiration [Term] id: GO:0019646 name: aerobic electron transport chain namespace: biological_process alt_id: GO:0006136 alt_id: GO:0006137 alt_id: GO:0006138 def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] subset: gosubset_prok synonym: "NADH-O2 electron transport" NARROW [] synonym: "succinate-O2 electron transport" NARROW [] synonym: "ubiquinone-8-O2 electron transport" NARROW [] is_a: GO:0009060 ! aerobic respiration is_a: GO:0022904 ! respiratory electron transport chain [Term] id: GO:0019647 name: formaldehyde assimilation via ribulose monophosphate cycle namespace: biological_process def: "The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde." [MetaCyc:PWY-1861] subset: gosubset_prok synonym: "formaldehyde assimilation via RuMP cycle" EXACT [] synonym: "ribulose monophosphate cycle" BROAD [] xref: MetaCyc:PWY-1861 is_a: GO:0019649 ! formaldehyde assimilation [Term] id: GO:0019648 name: formaldehyde assimilation via xylulose monophosphate cycle namespace: biological_process def: "The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds." [MetaCyc:P185-PWY] subset: gosubset_prok synonym: "formaldehyde assimilation via xylulose-5-phosphate cycle" EXACT [] synonym: "formaldehyde fixation cycle" EXACT [] xref: MetaCyc:P185-PWY is_a: GO:0019649 ! formaldehyde assimilation is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019649 name: formaldehyde assimilation namespace: biological_process def: "The pathways in which formaldehyde is processed and used as a carbon source for the cell." [GOC:ai] subset: gosubset_prok is_a: GO:0046292 ! formaldehyde metabolic process [Term] id: GO:0019650 name: glucose catabolic process to butanediol namespace: biological_process alt_id: GO:0030646 def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into 2,3-butanediol and other substances; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "butanediol fermentation" EXACT [] synonym: "glucose fermentation to butanediol" EXACT [] xref: MetaCyc:P125-PWY xref: Wikipedia:Butanediol_fermentation is_a: GO:0006007 ! glucose catabolic process is_a: GO:0019660 ! glycolytic fermentation is_a: GO:0034077 ! butanediol metabolic process [Term] id: GO:0019651 name: citrate catabolic process to diacetyl namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP." [MetaCyc:P126-PWY] subset: gosubset_prok synonym: "citrate fermentation to diacetyl" EXACT [] synonym: "diacetyl fermentation" EXACT [] is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019652 name: lactate fermentation to propionate and acetate namespace: biological_process def: "The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, MetaCyc:PROPFERM-PWY] subset: gosubset_prok synonym: "acrylate pathway" EXACT [] synonym: "nonrandomizing pathway" EXACT [] synonym: "propionate fermentation" EXACT [] xref: MetaCyc:PROPFERM-PWY is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019653 name: anaerobic purine base catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of purine bases, yielding energy in the form of ATP." [CHEBI:26386, GOC:mah] subset: gosubset_prok synonym: "anaerobic purine base catabolism" EXACT [GOC:curators] synonym: "anaerobic purine catabolic process" RELATED [GOC:curators] synonym: "anaerobic purine nucleobase catabolic process" EXACT [CHEBI:26386] synonym: "purine base fermentation" EXACT [GOC:curators] synonym: "purine fermentation" RELATED [GOC:curators] xref: MetaCyc:P164-PWY xref: MetaCyc:PWY-5044 xref: MetaCyc:PWY-5497 is_a: GO:0006145 ! purine base catabolic process is_a: GO:0019666 ! nitrogenous compound fermentation [Term] id: GO:0019654 name: acetate fermentation namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP." [CHEBI:30089, GOC:jl, MetaCyc:P142-PWY] subset: gosubset_prok xref: MetaCyc:P142-PWY is_a: GO:0006083 ! acetate metabolic process is_a: GO:0006113 ! fermentation [Term] id: GO:0019655 name: glucose catabolic process to ethanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose." [ISBN:0716720094] subset: gosubset_prok synonym: "ethanol fermentation" EXACT [] synonym: "glucose fermentation to ethanol" EXACT [] xref: Wikipedia:Ethanol_fermentation is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019656 name: glucose catabolic process to D-lactate and ethanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule." [GOC:jl, MetaCyc:P122-PWY] subset: gosubset_prok synonym: "glucose fermentation to D-lactate and ethanol" EXACT [] synonym: "heterofermentation" EXACT [] synonym: "heterofermentative lactate fermentation" EXACT [] synonym: "heterofermentative pathway" EXACT [] synonym: "heterolactate fermentation" EXACT [] synonym: "heterolactic fermentation" EXACT [] xref: MetaCyc:P122-PWY is_a: GO:0019659 ! glucose catabolic process to lactate is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019657 name: pyruvate fermentation to propionate namespace: biological_process def: "The anaerobic conversion of pyruvate to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate." [MetaCyc:P108-PWY] subset: gosubset_prok synonym: "succinate-propionate fermentation" EXACT [] xref: MetaCyc:P108-PWY is_a: GO:0006105 ! succinate metabolic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019658 name: glucose catabolic process to lactate and acetate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP." [MetaCyc:P124-PWY] subset: gosubset_prok synonym: "bifidum pathway" EXACT [] synonym: "glucose fermentation to lactate and acetate" EXACT [] xref: MetaCyc:P124-PWY is_a: GO:0019659 ! glucose catabolic process to lactate is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019659 name: glucose catabolic process to lactate namespace: biological_process def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl] subset: gosubset_prok synonym: "glucose fermentation to lactate" EXACT [] synonym: "lactate fermentation" EXACT [] xref: Wikipedia:Lactic_acid_fermentation is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006089 ! lactate metabolic process is_a: GO:0006113 ! fermentation [Term] id: GO:0019660 name: glycolytic fermentation namespace: biological_process def: "Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:curators] subset: gosubset_prok is_a: GO:0006006 ! glucose metabolic process is_a: GO:0006113 ! fermentation [Term] id: GO:0019661 name: glucose catabolic process to lactate via pyruvate namespace: biological_process def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via pyruvate, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, http://dwb.unl.edu/] subset: gosubset_prok synonym: "glucose fermentation to lactate via pyruvate" EXACT [] synonym: "homofermentation" EXACT [] synonym: "homofermentative lactate fermentation" EXACT [] synonym: "homofermentative pathway" EXACT [] synonym: "homolactate fermentation" EXACT [] synonym: "homolactic fermentation" EXACT [] is_a: GO:0019659 ! glucose catabolic process to lactate is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019662 name: non-glycolytic fermentation namespace: biological_process def: "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, MetaCyc:Fermentation] subset: gosubset_prok is_a: GO:0006113 ! fermentation [Term] id: GO:0019664 name: glucose catabolic process to mixed acids namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP." [MetaCyc:FERMENTATION-PWY] subset: gosubset_prok synonym: "glucose fermentation to mixed acids" EXACT [] synonym: "mixed acid fermentation" EXACT [] xref: Wikipedia:Mixed_acid_fermentation is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019665 name: anaerobic amino acid catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:curators, GOC:jl, MetaCyc:Fermentation] subset: gosubset_prok synonym: "amino acid fermentation" EXACT [] is_a: GO:0006113 ! fermentation is_a: GO:0009063 ! cellular amino acid catabolic process [Term] id: GO:0019666 name: nitrogenous compound fermentation namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP." [GOC:mah] subset: gosubset_prok synonym: "nitrogenous compound catabolic process " BROAD [] is_a: GO:0006113 ! fermentation [Term] id: GO:0019667 name: anaerobic L-alanine catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP." [GOC:jl] subset: gosubset_prok synonym: "L-alanine fermentation" EXACT [] is_a: GO:0019665 ! anaerobic amino acid catabolic process is_a: GO:0042853 ! L-alanine catabolic process [Term] id: GO:0019668 name: anaerobic catabolism of pairs of amino acids namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP." [GOC:mah, PMID:13140081] subset: gosubset_prok synonym: "cofermentation of pairs of amino acids" EXACT [] synonym: "Stickland reaction" NARROW [] is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019669 name: anaerobic glycine catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP." [GOC:jl] subset: gosubset_prok synonym: "glycine fermentation" EXACT [] is_a: GO:0006546 ! glycine catabolic process is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019670 name: anaerobic glutamate catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP." [GOC:jl] subset: gosubset_prok synonym: "glutamate fermentation" EXACT [] is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019671 name: glutamate catabolic process via mesaconate and citramalate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP." [MetaCyc:GLUDEG-II-PWY] subset: gosubset_prok synonym: "glutamate fermentation via mesaconate and citramalate" EXACT [] xref: MetaCyc:GLUDEG-II-PWY is_a: GO:0019670 ! anaerobic glutamate catabolic process [Term] id: GO:0019672 name: ethanol-acetate fermentation to butyrate and caproate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP." [MetaCyc:P127-PWY] subset: gosubset_prok is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019673 name: GDP-mannose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "GDP-mannose metabolism" EXACT [] is_a: GO:0006013 ! mannose metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0019674 name: NAD metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] subset: gosubset_prok synonym: "NAD (oxidized) metabolic process" EXACT [] synonym: "NAD (oxidized) metabolism" EXACT [] synonym: "NAD metabolism" EXACT [] synonym: "NAD phosphorylation and dephosphorylation" NARROW [] synonym: "nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide metabolism" EXACT [] synonym: "oxidized NAD metabolic process" EXACT [] synonym: "oxidized NAD metabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide metabolism" EXACT [] xref: Reactome:1253508 "Nicotinate metabolism" xref: Reactome:1280448 "Nicotinate metabolism" xref: Reactome:1299281 "Nicotinate metabolism" xref: Reactome:1327026 "Nicotinate metabolism" xref: Reactome:1353120 "Nicotinate metabolism" xref: Reactome:1373309 "Nicotinate metabolism" xref: Reactome:1393322 "Nicotinate metabolism" xref: Reactome:1417820 "Nicotinate metabolism" xref: Reactome:1450918 "Nicotinate metabolism" xref: Reactome:1471298 "Nicotinate metabolism" xref: Reactome:1483271 "Nicotinate metabolism" xref: Reactome:1496944 "Nicotinate metabolism" xref: Reactome:1514331 "Nicotinate metabolism" xref: Reactome:1521199 "Nicotinate metabolism" xref: Reactome:1526944 "Nicotinate metabolism" xref: Reactome:1532682 "Nicotinate metabolism" xref: Reactome:1536095 "Nicotinate metabolism" xref: Reactome:1538063 "Nicotinate metabolism" xref: Reactome:1539345 "Nicotinate metabolism" xref: Reactome:1540347 "Nicotinate metabolism" xref: Reactome:196807 "Nicotinate metabolism" is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0019675 name: NAD phosphorylation and dephosphorylation namespace: biological_process def: "OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] comment: This term was made obsolete because it represents a process, NAD dephosphorylation, that does not exist. synonym: "nicotinamide adenine dinucleotide phosphorylation and dephosphorylation" EXACT [] is_obsolete: true consider: GO:0006739 consider: GO:0019674 [Term] id: GO:0019676 name: ammonia assimilation cycle namespace: biological_process def: "The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen." [MetaCyc:AMMASSIM-PWY] subset: gosubset_prok synonym: "glutamate metabolic process via glutamine and ammonia" EXACT [] synonym: "glutamate metabolism via glutamine and ammonia" EXACT [] xref: MetaCyc:AMMASSIM-PWY xref: MetaCyc:PWY-3282 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006541 ! glutamine metabolic process [Term] id: GO:0019677 name: NAD catabolic process namespace: biological_process alt_id: GO:0006737 def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] subset: gosubset_prok synonym: "NAD (oxidized) catabolic process" EXACT [] synonym: "NAD (oxidized) catabolism" EXACT [] synonym: "NAD (reduced) catabolic process" EXACT [] synonym: "NAD (reduced) catabolism" EXACT [] synonym: "NAD breakdown" EXACT [] synonym: "NAD catabolism" EXACT [] synonym: "NAD degradation" EXACT [] synonym: "NADH catabolic process" EXACT [] synonym: "NADH catabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide catabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide catabolism" EXACT [] synonym: "oxidized NAD catabolic process" EXACT [] synonym: "oxidized NAD catabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide catabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide catabolism" EXACT [] synonym: "reduced NAD catabolic process" EXACT [] synonym: "reduced NAD catabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide catabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide catabolism" EXACT [] is_a: GO:0019364 ! pyridine nucleotide catabolic process is_a: GO:0019674 ! NAD metabolic process [Term] id: GO:0019678 name: propionate metabolic process, methylmalonyl pathway namespace: biological_process def: "The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway." [GOC:go_curators] subset: gosubset_prok synonym: "propionate metabolism, methylmalonyl pathway" EXACT [] xref: MetaCyc:PROPIONMET-PWY is_a: GO:0019541 ! propionate metabolic process [Term] id: GO:0019679 name: propionate metabolic process, methylcitrate cycle namespace: biological_process def: "The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle." [GOC:go_curators] subset: gosubset_prok synonym: "propionate metabolism, methylcitrate cycle" EXACT [] xref: MetaCyc:PWY0-42 is_a: GO:0019541 ! propionate metabolic process [Term] id: GO:0019680 name: L-methylmalonyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-methylmalonyl-CoA anabolism" EXACT [] synonym: "L-methylmalonyl-CoA biosynthesis" EXACT [] synonym: "L-methylmalonyl-CoA formation" EXACT [] synonym: "L-methylmalonyl-CoA synthesis" EXACT [] xref: MetaCyc:PWY0-43 is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046491 ! L-methylmalonyl-CoA metabolic process [Term] id: GO:0019681 name: acetyl-CoA assimilation pathway namespace: biological_process def: "The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell." [MetaCyc:P22-PWY] subset: gosubset_prok synonym: "acetyl-CoA catabolic process to 2-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolic process to 2-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolic process to alpha-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolic process to alpha-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to 2-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to 2-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to alpha-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to alpha-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0046356 ! acetyl-CoA catabolic process [Term] id: GO:0019682 name: glyceraldehyde-3-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glyceraldehyde 3-phosphate metabolic process" EXACT [] synonym: "glyceraldehyde 3-phosphate metabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0019683 name: glyceraldehyde-3-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glyceraldehyde 3-phosphate catabolic process" EXACT [] synonym: "glyceraldehyde 3-phosphate catabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate breakdown" EXACT [] synonym: "glyceraldehyde-3-phosphate catabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate degradation" EXACT [] is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046365 ! monosaccharide catabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0019684 name: photosynthesis, light reaction namespace: biological_process def: "The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I." [http://www.arabidopsis.org] synonym: "photolysis" RELATED [] xref: MetaCyc:PWY-101 xref: Wikipedia:Photolysis#Photolysis_in_photosynthesis is_a: GO:0006091 ! generation of precursor metabolites and energy relationship: part_of GO:0015979 ! photosynthesis [Term] id: GO:0019685 name: photosynthesis, dark reaction namespace: biological_process def: "A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions." [ISBN:0582015952] is_a: GO:0016051 ! carbohydrate biosynthetic process relationship: part_of GO:0015979 ! photosynthesis [Term] id: GO:0019686 name: purine nucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion is_a: GO:0042278 ! purine nucleoside metabolic process [Term] id: GO:0019687 name: pyruvate biosynthetic process from acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate." [GOC:go_curators] subset: gosubset_prok synonym: "pyruvate anabolism from acetate" EXACT [] synonym: "pyruvate formation from acetate" EXACT [] synonym: "pyruvate synthesis from acetate" EXACT [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0042866 ! pyruvate biosynthetic process [Term] id: GO:0019688 name: purine deoxyribonucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0019686 ! purine nucleoside interconversion is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0019689 name: pyrimidine nucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion [Term] id: GO:0019690 name: pyrimidine deoxyribonucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: gosubset_prok is_a: GO:0019689 ! pyrimidine nucleoside interconversion is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0019692 name: deoxyribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribose phosphate metabolism" EXACT [] is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0019693 name: ribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] subset: gosubset_prok synonym: "ribose phosphate metabolism" EXACT [] is_a: GO:0006014 ! D-ribose metabolic process [Term] id: GO:0019694 name: alkanesulfonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] subset: gosubset_prok synonym: "alkanesulfonate metabolism" EXACT [] synonym: "alkanesulphonate metabolic process" EXACT [] synonym: "alkanesulphonate metabolism" EXACT [] xref: MetaCyc:ALKANEMONOX-PWY is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0019695 name: choline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "choline metabolism" EXACT [] is_a: GO:0042439 ! ethanolamine-containing compound metabolic process [Term] id: GO:0019696 name: toluene oxidation via toluene-cis-1,2-dihydrodiol namespace: biological_process def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol." [MetaCyc:TOLUENE-DEG-DIOL-PWY] subset: gosubset_prok xref: MetaCyc:TOLUENE-DEG-DIOL-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019697 name: L-xylitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] subset: gosubset_prok synonym: "L-arabitol and xylitol degradation" BROAD [] synonym: "L-xylitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "L-xylitol degradation to xylulose 5-phosphate" EXACT [] synonym: "L-xylitol utilization" RELATED [] xref: MetaCyc:LARABITOLUTIL-PWY is_a: GO:0051160 ! L-xylitol catabolic process is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019698 name: D-galacturonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-galacturonate breakdown" EXACT [] synonym: "D-galacturonate catabolism" EXACT [] synonym: "D-galacturonate degradation" EXACT [] xref: MetaCyc:GALACTUROCAT-PWY is_a: GO:0046396 ! D-galacturonate metabolic process is_a: GO:0046397 ! galacturonate catabolic process [Term] id: GO:0019700 name: phosphonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] subset: gosubset_prok synonym: "phosphonate breakdown" EXACT [] synonym: "phosphonate catabolism" EXACT [] synonym: "phosphonate degradation" EXACT [] is_a: GO:0019634 ! phosphonate metabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0019701 name: peptidyl-arginine N5-methylation namespace: biological_process def: "The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine." [GOC:bf, PMID:9792625, RESID:AA0305] subset: gosubset_prok synonym: "peptidyl-arginine delta-N-methylation" EXACT [] xref: RESID:AA0305 is_a: GO:0035246 ! peptidyl-arginine N-methylation [Term] id: GO:0019702 name: protein-arginine N5-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues." [PMID:9873020] synonym: "protein-arginine delta-N-methyltransferase activity" EXACT [] synonym: "type IV PRMT activity" EXACT [] synonym: "type IV protein arginine methyltransferase activity" EXACT [] xref: EC:2.1.1.- is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0019703 name: coenzyme A-peptidyl-cysteine covalent linking namespace: biological_process def: "The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide." [RESID:AA0306] subset: gosubset_prok xref: RESID:AA0306 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0019704 name: peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine." [RESID:AA0307] subset: gosubset_prok synonym: "peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0307 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018377 ! protein myristoylation [Term] id: GO:0019705 name: protein-cysteine S-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a myristoyl group to a sulfur atom on a cysteine residue of a protein molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0019107 ! myristoyltransferase activity is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity [Term] id: GO:0019706 name: protein-cysteine S-palmitoleyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoleyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0016409 ! palmitoyltransferase activity is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity [Term] id: GO:0019707 name: protein-cysteine S-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] xref: EC:2.3.1.- is_a: GO:0016417 ! S-acyltransferase activity [Term] id: GO:0019708 name: peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine namespace: biological_process def: "The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins." [RESID:AA0309] subset: gosubset_prok synonym: "peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycine cholesteryl ester formation from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine" EXACT [] xref: RESID:AA0309 is_a: GO:0006501 ! C-terminal protein lipidation is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0019709 name: iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide namespace: biological_process def: "The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT [] xref: RESID:AA0310 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0019710 name: peptidyl-asparagine methylation namespace: biological_process alt_id: GO:0018018 def: "The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine." [RESID:AA0070, RESID:AA0311] subset: gosubset_prok xref: RESID:AA0070 xref: RESID:AA0311 is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0019711 name: peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid." [GOC:go_curators] subset: gosubset_prok synonym: "peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0019712 name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid namespace: biological_process def: "The methyl esterification of peptidyl-glutamic acid." [RESID:AA0072] subset: gosubset_prok synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid" EXACT [] xref: RESID:AA0072 is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine [Term] id: GO:0019713 name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine namespace: biological_process def: "The coupled methyl esterification and deamidation of peptidyl-glutamine." [RESID:AA0072] subset: gosubset_prok synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine" EXACT [] xref: RESID:AA0072 is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine is_a: GO:0019714 ! peptidyl-glutamine esterification [Term] id: GO:0019714 name: peptidyl-glutamine esterification namespace: biological_process def: "The addition of an ester group to a glutamine residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0019715 name: peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid namespace: biological_process def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0027] comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. subset: gosubset_prok xref: RESID:AA0027 is_a: GO:0042264 ! peptidyl-aspartic acid hydroxylation [Term] id: GO:0019716 name: N-terminal peptidyl-alanine monomethylation namespace: biological_process def: "The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine." [RESID:AA0061] subset: gosubset_prok xref: RESID:AA0061 is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation [Term] id: GO:0019717 name: synaptosome namespace: cellular_component def: "Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. xref: Wikipedia:Synaptosome is_a: GO:0005624 ! membrane fraction [Term] id: GO:0019718 name: rough microsome namespace: cellular_component def: "Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. is_a: GO:0005792 ! microsome [Term] id: GO:0019719 name: smooth microsome namespace: cellular_component def: "Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. is_a: GO:0005792 ! microsome [Term] id: GO:0019720 name: Mo-molybdopterin cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257] subset: gosubset_prok synonym: "Mo-molybdopterin cofactor metabolism" EXACT [] synonym: "Moco metabolic process" BROAD [] synonym: "Moco metabolism" BROAD [] is_a: GO:0043545 ! molybdopterin cofactor metabolic process [Term] id: GO:0019722 name: calcium-mediated signaling namespace: biological_process def: "A series of molecular signals in which a cell uses calcium ions to convert a signal into a response." [GOC:ceb] synonym: "calcium ion signaling" EXACT [] synonym: "calcium signaling" EXACT [] synonym: "calcium signalling" EXACT [] synonym: "calcium-mediated signalling" EXACT [] xref: Wikipedia:Calcium_signaling is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0019724 name: B cell mediated immunity namespace: biological_process def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "B lymphocyte mediated immune effector process" EXACT [] synonym: "B lymphocyte mediated immunity" EXACT [] synonym: "B-cell mediated immune effector process" EXACT [] synonym: "B-cell mediated immunity" EXACT [] synonym: "B-lymphocyte mediated immune effector process" EXACT [] synonym: "B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_candida subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok is_a: GO:0009987 ! cellular process is_a: GO:0042592 ! homeostatic process [Term] id: GO:0019726 name: mevaldate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH." [EC:1.1.1.33, RHEA:20196] synonym: "(R)-mevalonate:NADP+ oxidoreductase" EXACT [EC:1.1.1.33] synonym: "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase" EXACT [EC:1.1.1.33] xref: EC:1.1.1.33 xref: KEGG:R02247 xref: MetaCyc:MEVALDATE-REDUCTASE-NADPH-RXN xref: RHEA:20196 is_a: GO:0004495 ! mevaldate reductase activity [Term] id: GO:0019727 name: mevaldate reductase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH." [EC:1.1.1.32, RHEA:13224] xref: EC:1.1.1.32 xref: KEGG:R02246 xref: MetaCyc:MEVALDATE-REDUCTASE-RXN xref: RHEA:13224 is_a: GO:0004495 ! mevaldate reductase activity [Term] id: GO:0019728 name: peptidyl-allysine oxidation to 2-aminoadipic acid namespace: biological_process def: "The oxidation of allysine to 2-aminoadipic acid." [RESID:AA0122] subset: gosubset_prok xref: RESID:AA0370 is_a: GO:0018158 ! protein oxidation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0019729 name: peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine namespace: biological_process def: "The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0189] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. subset: gosubset_prok synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] xref: RESID:AA0189 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0019730 name: antimicrobial humoral response namespace: biological_process alt_id: GO:0006960 alt_id: GO:0019735 def: "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0006959 ! humoral immune response is_a: GO:0051707 ! response to other organism [Term] id: GO:0019731 name: antibacterial humoral response namespace: biological_process alt_id: GO:0006961 alt_id: GO:0019733 def: "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0019730 ! antimicrobial humoral response is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0019732 name: antifungal humoral response namespace: biological_process alt_id: GO:0006966 alt_id: GO:0019734 def: "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0019730 ! antimicrobial humoral response is_a: GO:0050832 ! defense response to fungus [Term] id: GO:0019736 name: peptidyl-sarcosine incorporation namespace: biological_process def: "The incorporation of sarcosine (N-methylglycine) into non-coded peptides." [RESID:AA0063] subset: gosubset_prok xref: RESID:AA0063 is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0019740 name: nitrogen utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0019741 name: pentacyclic triterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentacyclic triterpenoid breakdown" EXACT [] synonym: "pentacyclic triterpenoid catabolism" EXACT [] synonym: "pentacyclic triterpenoid degradation" EXACT [] is_a: GO:0016105 ! triterpenoid catabolic process is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process [Term] id: GO:0019742 name: pentacyclic triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentacyclic triterpenoid metabolism" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process [Term] id: GO:0019743 name: hopanoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] subset: gosubset_prok synonym: "hopanoid breakdown" EXACT [] synonym: "hopanoid catabolism" EXACT [] synonym: "hopanoid degradation" EXACT [] is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process is_a: GO:0019744 ! hopanoid metabolic process [Term] id: GO:0019744 name: hopanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] subset: gosubset_prok synonym: "hopanoid metabolism" EXACT [] is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process [Term] id: GO:0019745 name: pentacyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentacyclic triterpenoid anabolism" EXACT [] synonym: "pentacyclic triterpenoid biosynthesis" EXACT [] synonym: "pentacyclic triterpenoid formation" EXACT [] synonym: "pentacyclic triterpenoid synthesis" EXACT [] is_a: GO:0016104 ! triterpenoid biosynthetic process is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process [Term] id: GO:0019746 name: hopanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] subset: gosubset_prok synonym: "hopanoid anabolism" EXACT [] synonym: "hopanoid biosynthesis" EXACT [] synonym: "hopanoid formation" EXACT [] synonym: "hopanoid synthesis" EXACT [] is_a: GO:0019744 ! hopanoid metabolic process is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process [Term] id: GO:0019747 name: regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of isoprenoid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0019748 name: secondary metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "secondary metabolism" EXACT [] xref: Wikipedia:Secondary_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0019749 name: cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte namespace: biological_process def: "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai] is_a: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport [Term] id: GO:0019750 name: chloroplast localization namespace: biological_process def: "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants." [GOC:bf, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "chloroplast localisation" EXACT [GOC:mah] is_a: GO:0051644 ! plastid localization [Term] id: GO:0019751 name: polyol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [CHEBI:26191, GOC:go_curators] subset: gosubset_prok synonym: "polyhydric alcohol metabolic process" EXACT [] synonym: "polyol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0019752 name: carboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "carboxylic acid metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0019755 name: one-carbon compound transport namespace: biological_process def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "one carbon compound transport" EXACT [] is_a: GO:0006810 ! transport [Term] id: GO:0019756 name: cyanogenic glycoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyanogenic glycoside anabolism" EXACT [] synonym: "cyanogenic glycoside biosynthesis" EXACT [] synonym: "cyanogenic glycoside formation" EXACT [] synonym: "cyanogenic glycoside synthesis" EXACT [] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0042341 ! cyanogenic glycoside metabolic process [Term] id: GO:0019757 name: glycosinolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] subset: gosubset_prok synonym: "glycosinolate metabolism" EXACT [] is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0019758 name: glycosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] subset: gosubset_prok synonym: "glycosinolate anabolism" EXACT [] synonym: "glycosinolate biosynthesis" EXACT [] synonym: "glycosinolate formation" EXACT [] synonym: "glycosinolate synthesis" EXACT [] is_a: GO:0016144 ! S-glycoside biosynthetic process is_a: GO:0019757 ! glycosinolate metabolic process [Term] id: GO:0019759 name: glycosinolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] subset: gosubset_prok synonym: "glycosinolate breakdown" EXACT [] synonym: "glycosinolate catabolism" EXACT [] synonym: "glycosinolate degradation" EXACT [] is_a: GO:0016145 ! S-glycoside catabolic process is_a: GO:0019757 ! glycosinolate metabolic process [Term] id: GO:0019760 name: glucosinolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans." [CHEBI:24279, GOC:curators] subset: gosubset_prok synonym: "glucosinolate metabolism" EXACT [] is_a: GO:0019757 ! glycosinolate metabolic process [Term] id: GO:0019761 name: glucosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] subset: gosubset_prok synonym: "glucosinolate anabolism" EXACT [] synonym: "glucosinolate biosynthesis" EXACT [] synonym: "glucosinolate formation" EXACT [] synonym: "glucosinolate synthesis" EXACT [] is_a: GO:0019758 ! glycosinolate biosynthetic process is_a: GO:0019760 ! glucosinolate metabolic process [Term] id: GO:0019762 name: glucosinolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] subset: gosubset_prok synonym: "glucosinolate breakdown" EXACT [] synonym: "glucosinolate catabolism" EXACT [] synonym: "glucosinolate degradation" EXACT [] xref: MetaCyc:PWY-5267 is_a: GO:0019759 ! glycosinolate catabolic process is_a: GO:0019760 ! glucosinolate metabolic process [Term] id: GO:0019763 name: immunoglobulin receptor activity namespace: molecular_function alt_id: GO:0016489 def: "Combining with the Fc region of an immunoglobulin protein to initiate a change in cell activity." [ISBN:0198547684] synonym: "FC receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019764 name: high affinity Fc receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it is an unnecessary grouping term. is_obsolete: true consider: GO:0019768 consider: GO:0019771 [Term] id: GO:0019765 name: low affinity Fc receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it is undefined and is an unnecessary grouping term. is_obsolete: true consider: GO:0019769 consider: GO:0019772 [Term] id: GO:0019766 name: IgA receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of an IgA isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019763 ! immunoglobulin receptor activity is_a: GO:0019862 ! IgA binding [Term] id: GO:0019767 name: IgE receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019763 ! immunoglobulin receptor activity is_a: GO:0019863 ! IgE binding [Term] id: GO:0019768 name: high affinity IgE receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "high affinity Fc receptor activity" RELATED [] is_a: GO:0019767 ! IgE receptor activity [Term] id: GO:0019769 name: low affinity IgE receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "low affinity Fc receptor activity" RELATED [] is_a: GO:0019767 ! IgE receptor activity [Term] id: GO:0019770 name: IgG receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019763 ! immunoglobulin receptor activity is_a: GO:0019864 ! IgG binding [Term] id: GO:0019771 name: high affinity IgG receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "high affinity Fc receptor activity" RELATED [] is_a: GO:0019770 ! IgG receptor activity [Term] id: GO:0019772 name: low affinity IgG receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "low affinity Fc receptor activity" RELATED [] is_a: GO:0019770 ! IgG receptor activity [Term] id: GO:0019773 name: proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005839 ! proteasome core complex [Term] id: GO:0019774 name: proteasome core complex, beta-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005839 ! proteasome core complex [Term] id: GO:0019775 name: FAT10 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein FAT10 to other proteins." [GOC:mah, PMID:12826404] synonym: "FAT10 conjugating enzyme activity" RELATED [] is_a: GO:0019787 ! small conjugating protein ligase activity [Term] id: GO:0019776 name: Atg8 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate." [GOC:mah, PMID:12826404] synonym: "APG8 conjugating enzyme activity" EXACT [] synonym: "APG8 ligase activity" EXACT [] synonym: "Atg8 conjugating enzyme activity" EXACT [] is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0019777 name: Atg12 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg12 to other proteins." [GOC:mah, PMID:12826404] synonym: "APG12 conjugating enzyme activity" EXACT [] synonym: "APG12 ligase activity" EXACT [] synonym: "Atg12 conjugating enzyme activity" RELATED [] is_a: GO:0019787 ! small conjugating protein ligase activity [Term] id: GO:0019778 name: APG12 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0019779 name: APG8 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "APG7" EXACT [] is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0019780 name: FAT10 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0019781 name: NEDD8 activating enzyme activity namespace: molecular_function alt_id: GO:0019944 def: "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924] synonym: "RUB1 activating enzyme activity" EXACT [] is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0019782 name: ISG15 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "UBE1L" NARROW [] is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0019783 name: small conjugating protein-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah] subset: gosubset_prok synonym: "ubiquitin-like specific protease activity" NARROW [] synonym: "ubiquitin-like-protein-specific protease activity" NARROW [] is_a: GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0019784 name: NEDD8-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah] is_a: GO:0019783 ! small conjugating protein-specific protease activity [Term] id: GO:0019785 name: ISG15-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates." [GOC:mah] is_a: GO:0019783 ! small conjugating protein-specific protease activity [Term] id: GO:0019786 name: APG8-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah] synonym: "APG8-PE hydrolase" RELATED [] is_a: GO:0019783 ! small conjugating protein-specific protease activity [Term] id: GO:0019787 name: small conjugating protein ligase activity namespace: molecular_function alt_id: GO:0008639 alt_id: GO:0008640 def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] subset: gosubset_prok synonym: "E2" NARROW [] synonym: "small protein conjugating enzyme activity" EXACT [] synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like-protein ligase activity" NARROW [] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0019788 name: NEDD8 ligase activity namespace: molecular_function alt_id: GO:0016976 alt_id: GO:0019945 alt_id: GO:0042295 def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue." [GOC:mah] synonym: "Hub1 conjugating enzyme activity" EXACT [] synonym: "NEDD8 conjugating enzyme activity" EXACT [] synonym: "RUB1 conjugating enzyme activity" EXACT [] is_a: GO:0019787 ! small conjugating protein ligase activity [Term] id: GO:0019789 name: SUMO ligase activity namespace: molecular_function alt_id: GO:0016930 alt_id: GO:0019949 def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function." [GOC:rn, PMID:11031248, PMID:11265250] synonym: "SMT3 conjugating enzyme" EXACT [] synonym: "SUMO conjugating enzyme activity" EXACT [] is_a: GO:0019787 ! small conjugating protein ligase activity [Term] id: GO:0019790 name: ubiquitin-like hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. is_obsolete: true consider: GO:0019783 [Term] id: GO:0019791 name: FAT10 hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. is_obsolete: true consider: GO:0019783 [Term] id: GO:0019792 name: APG12 hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. is_obsolete: true consider: GO:0019783 [Term] id: GO:0019793 name: ISG15 carrier activity namespace: molecular_function def: "Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other." [GOC:jl, http://www.copewithcytokines.de/] synonym: "interferon-stimulated gene-15 carrier activity" NARROW [] is_a: GO:0008320 ! protein transmembrane transporter activity [Term] id: GO:0019794 name: nonprotein amino acid metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. subset: gosubset_prok synonym: "nonprotein amino acid metabolism" EXACT [] is_obsolete: true replaced_by: GO:0006520 [Term] id: GO:0019795 name: nonprotein amino acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins." [GOC:ma] comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. subset: gosubset_prok synonym: "nonprotein amino acid anabolism" EXACT [] synonym: "nonprotein amino acid biosynthesis" EXACT [] synonym: "nonprotein amino acid formation" EXACT [] synonym: "nonprotein amino acid synthesis" EXACT [] is_obsolete: true replaced_by: GO:0008652 [Term] id: GO:0019796 name: nonprotein amino acid catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. subset: gosubset_prok synonym: "nonprotein amino acid breakdown" EXACT [] synonym: "nonprotein amino acid catabolism" EXACT [] synonym: "nonprotein amino acid degradation" EXACT [] is_obsolete: true replaced_by: GO:0009063 [Term] id: GO:0019797 name: procollagen-proline 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7] synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.7] synonym: "procollagen-proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] synonym: "proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] synonym: "prolyl 3-hydroxylase activity" EXACT [EC:1.14.11.7] synonym: "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity" EXACT [EC:1.14.11.7] synonym: "protocollagen proline 3-hydroxylase activity" EXACT [EC:1.14.11.7] xref: EC:1.14.11.7 xref: KEGG:R03218 xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN is_a: GO:0019798 ! procollagen-proline dioxygenase activity is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity [Term] id: GO:0019798 name: procollagen-proline dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2, EC:1.14.11.7, GOC:mah] xref: EC:1.14.11.- is_a: GO:0031543 ! peptidyl-proline dioxygenase activity [Term] id: GO:0019799 name: tubulin N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin acetylase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "TAT activity" EXACT [EC:2.3.1.108] synonym: "tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] xref: EC:2.3.1.108 xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN is_a: GO:0034212 ! peptide N-acetyltransferase activity [Term] id: GO:0019800 name: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan namespace: biological_process def: "The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain." [PMID:1898736, RESID:AA0219] subset: gosubset_prok synonym: "peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan" EXACT [] xref: RESID:AA0219 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030204 ! chondroitin sulfate metabolic process [Term] id: GO:0019801 name: cyclization of asparagine involved in intein-mediated protein splicing namespace: biological_process def: "The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0302] comment: See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. subset: gosubset_prok synonym: "cyclization of asparagine, during protein splicing" RELATED [GOC:dph, GOC:tb] xref: RESID:AA0302 is_a: GO:0006528 ! asparagine metabolic process relationship: part_of GO:0016539 ! intein-mediated protein splicing [Term] id: GO:0019802 name: cyclization of glutamine involved in intein-mediated protein splicing namespace: biological_process def: "The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing." [GOC:dph, GOC:tb, RESID:AA0303] comment: Note that this term should not be confused with 'peptidyl-pyroglutamic acid biosynthesis, using glutaminyl-peptide cyclotransferase ; GO:0017186'. See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. subset: gosubset_prok synonym: "cyclization of glutamine, during protein splicing" RELATED [GOC:dph, GOC:tb] xref: RESID:AA0303 is_a: GO:0006541 ! glutamine metabolic process relationship: part_of GO:0016539 ! intein-mediated protein splicing [Term] id: GO:0019803 name: peptidyl-aspartic acid carboxylation namespace: biological_process def: "The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid." [RESID:AA0304] subset: gosubset_prok xref: RESID:AA0304 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018214 ! protein carboxylation [Term] id: GO:0019804 name: quinolinate synthetase complex namespace: cellular_component def: "OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902] comment: This term was made obsolete because there is no evidence that a physical complex forms; although the phrase "quinolinate synthetase complex" is occasionally used in the literature, it refers to two enzymes that act as monomers. is_obsolete: true consider: GO:0008743 consider: GO:0008987 [Term] id: GO:0019805 name: quinolinate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] subset: gosubset_prok synonym: "quinolinate anabolism" EXACT [] synonym: "quinolinate biosynthesis" EXACT [] synonym: "quinolinate formation" EXACT [] synonym: "quinolinate synthesis" EXACT [] is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046874 ! quinolinate metabolic process [Term] id: GO:0019806 name: bromide peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 R-H + 2 bromide + hydrogen peroxide = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide." [EC:1.11.1.10] subset: gosubset_prok synonym: "bromoperoxidase activity" EXACT [] xref: EC:1.11.1.- is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0019807 name: aspartoacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate." [EC:3.5.1.15] subset: gosubset_prok synonym: "acetyl-aspartic deaminase activity" EXACT [EC:3.5.1.15] synonym: "acylase II" RELATED [EC:3.5.1.15] synonym: "aminoacylase II activity" RELATED [EC:3.5.1.15] synonym: "N-acetylaspartate amidohydrolase activity" EXACT [EC:3.5.1.15] synonym: "N-acyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.15] xref: EC:3.5.1.15 xref: MetaCyc:ASPARTOACYLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0019808 name: polyamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups." [GOC:ai] subset: gosubset_prok is_a: GO:0043176 ! amine binding [Term] id: GO:0019809 name: spermidine binding namespace: molecular_function def: "Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] is_a: GO:0019808 ! polyamine binding [Term] id: GO:0019810 name: putrescine binding namespace: molecular_function def: "Interacting selectively and non-covalently with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] is_a: GO:0019808 ! polyamine binding [Term] id: GO:0019811 name: cocaine binding namespace: molecular_function def: "Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0008144 ! drug binding [Term] id: GO:0019812 name: Type I site-specific deoxyribonuclease complex namespace: cellular_component def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748] subset: gosubset_prok synonym: "Type I restriction enzyme complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0019813 name: Type III site-specific deoxyribonuclease complex namespace: cellular_component def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] subset: gosubset_prok synonym: "Type III restriction enzyme complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0019814 name: immunoglobulin complex namespace: cellular_component def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. subset: goslim_pir is_a: GO:0043234 ! protein complex [Term] id: GO:0019815 name: B cell receptor complex namespace: cellular_component alt_id: GO:0042570 def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "antibody" RELATED [GOC:mah] synonym: "B cell receptor accessory molecule complex" RELATED [] synonym: "B lymphocyte receptor complex" EXACT [] synonym: "B-cell receptor complex" EXACT [] synonym: "B-lymphocyte receptor complex" EXACT [] synonym: "BCR complex" EXACT [] synonym: "immunoglobulin complex, membrane bound" EXACT [] is_a: GO:0019814 ! immunoglobulin complex is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0019816 name: B cell receptor accessory molecule complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecule and not a location or complex. is_obsolete: true consider: GO:0019815 [Term] id: GO:0019817 name: vesicle fusion with peroxisome namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome." [GOC:jid] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0019819 name: P1 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019820 name: P2 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019821 name: P3 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019822 name: P4 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019823 name: P5 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019824 name: P6 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019825 name: oxygen binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cytochrome P450" NARROW [] synonym: "cytochrome P450 activity" RELATED [] xref: Reactome:4477 "oxygen binding" is_a: GO:0005488 ! binding [Term] id: GO:0019826 name: oxygen sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)." [GOC:mah] is_a: GO:0019825 ! oxygen binding [Term] id: GO:0019827 name: stem cell maintenance namespace: biological_process def: "The process in which an organism retains a population of stem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:mah, ISBN:0878932437] synonym: "maintenance of pluripotency" RELATED [GOC:vk] is_a: GO:0032502 ! developmental process is_a: GO:0045596 ! negative regulation of cell differentiation relationship: part_of GO:0048864 ! stem cell development [Term] id: GO:0019828 name: aspartic-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." [GOC:ai] synonym: "aspartic protease inhibitor activity" EXACT [] is_a: GO:0004866 ! endopeptidase inhibitor activity [Term] id: GO:0019829 name: cation-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] subset: gosubset_prok synonym: "cation ABC transporter" NARROW [] synonym: "plasma membrane cation-transporting ATPase" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions [Term] id: GO:0019830 name: cadmium sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046686 [Term] id: GO:0019831 name: chromate sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046687 [Term] id: GO:0019832 name: mercuric sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046689 [Term] id: GO:0019833 name: ice nucleation activity namespace: molecular_function def: "OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation." [GOC:ai, GOC:jl] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0009405 replaced_by: GO:0042309 replaced_by: GO:0050825 [Term] id: GO:0019834 name: phospholipase A2 inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the enzyme phospholipase A2." [GOC:ai] is_a: GO:0004859 ! phospholipase inhibitor activity [Term] id: GO:0019835 name: cytolysis namespace: biological_process def: "The rupture of cell membranes and the loss of cytoplasm." [SP_KW:KW-0204] subset: gosubset_prok synonym: "autolysin activity" RELATED [] synonym: "bacteriocin activity" RELATED [] synonym: "bacteriolytic toxin activity" RELATED [] synonym: "holin" RELATED [] synonym: "lysin activity" RELATED [] synonym: "lysis" BROAD [] synonym: "necrosis" RELATED [] xref: Wikipedia:Cytolysis is_a: GO:0008219 ! cell death [Term] id: GO:0019836 name: hemolysis by symbiont of host erythrocytes namespace: biological_process def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, SP_KW:KW-0354] subset: gosubset_prok synonym: "haemolysis in host" EXACT [] synonym: "hemolysin activity" RELATED [] synonym: "hemolysis by symbiont of host RBCs" EXACT [CL:0000232] synonym: "hemolysis by symbiont of host red blood cells" EXACT [CL:0000232] synonym: "regulation of cytolysis of host cells by symbiont" EXACT [GOC:dph, GOC:tb] is_a: GO:0001897 ! cytolysis by symbiont of host cells is_a: GO:0052331 ! hemolysis in other organism involved in symbiotic interaction [Term] id: GO:0019837 name: herbicide susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0009635 [Term] id: GO:0019838 name: growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators] synonym: "neurotrophin TRK receptor activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019840 name: isoprenoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0008289 ! lipid binding [Term] id: GO:0019841 name: retinol binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [CHEBI:50211, GOC:curators] synonym: "vitamin A1 alcohol binding" EXACT [] synonym: "vitamin A1 binding" EXACT [] is_a: GO:0005501 ! retinoid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0019842 name: vitamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0019843 name: rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0019844 name: endotoxin activity namespace: molecular_function def: "OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0005622 consider: GO:0009405 consider: GO:0050827 [Term] id: GO:0019845 name: exotoxin activity namespace: molecular_function def: "OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0005576 consider: GO:0009405 consider: GO:0050827 [Term] id: GO:0019846 name: enterotoxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0009405 consider: GO:0050827 [Term] id: GO:0019847 name: neurotoxin activity namespace: molecular_function def: "OBSOLETE. Acts to inhibit neural function in another living organism." [GOC:jl] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0009405 consider: GO:0050827 [Term] id: GO:0019848 name: conotoxin activity namespace: molecular_function def: "OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0019855 consider: GO:0046929 [Term] id: GO:0019849 name: cytotoxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause injury to other living cells." [GOC:jl] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0009405 consider: GO:0050827 [Term] id: GO:0019852 name: L-ascorbic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ascorbate metabolic process" EXACT [] synonym: "ascorbate metabolism" EXACT [] synonym: "L-ascorbic acid metabolism" EXACT [] synonym: "vitamin C metabolic process" EXACT [] synonym: "vitamin C metabolism" EXACT [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0019853 name: L-ascorbic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [CHEBI:38290, GOC:ma, ISBN:0198547684] subset: gosubset_prok synonym: "ascorbate biosynthesis" EXACT [] synonym: "ascorbate biosynthetic process" EXACT [] synonym: "L-ascorbic acid anabolism" EXACT [] synonym: "L-ascorbic acid biosynthesis" EXACT [] synonym: "L-ascorbic acid formation" EXACT [] synonym: "L-ascorbic acid synthesis" EXACT [] synonym: "vitamin C biosynthesis" EXACT [] synonym: "vitamin C biosynthetic process" EXACT [] xref: MetaCyc:PWY-882 is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0019854 name: L-ascorbic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [CHEBI:38290, GOC:go_curators] subset: gosubset_prok synonym: "ascorbate catabolic process" EXACT [] synonym: "ascorbate catabolism" EXACT [] synonym: "L-ascorbic acid breakdown" EXACT [] synonym: "L-ascorbic acid catabolism" EXACT [] synonym: "L-ascorbic acid degradation" EXACT [] synonym: "vitamin C catabolic process" EXACT [] synonym: "vitamin C catabolism" EXACT [] xref: MetaCyc:PWY0-301 is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0019855 name: calcium channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a calcium channel." [GOC:mah] is_a: GO:0005246 ! calcium channel regulator activity is_a: GO:0008200 ! ion channel inhibitor activity [Term] id: GO:0019856 name: pyrimidine base biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] subset: gosubset_prok synonym: "pyrimidine base anabolism" EXACT [] synonym: "pyrimidine base biosynthesis" EXACT [] synonym: "pyrimidine base formation" EXACT [] synonym: "pyrimidine base synthesis" EXACT [] synonym: "pyrimidine nucleobase biosynthetic process" EXACT [CHEBI:26432] is_a: GO:0006206 ! pyrimidine base metabolic process is_a: GO:0046112 ! nucleobase biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0019857 name: 5-methylcytosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA." [GOC:ai] subset: gosubset_prok synonym: "5-methylcytosine metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine base metabolic process [Term] id: GO:0019858 name: cytosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:ai] subset: gosubset_prok synonym: "cytosine metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine base metabolic process [Term] id: GO:0019859 name: thymine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] subset: gosubset_prok synonym: "thymine metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine base metabolic process [Term] id: GO:0019860 name: uracil metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] subset: gosubset_prok synonym: "uracil metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine base metabolic process [Term] id: GO:0019861 name: flagellum namespace: cellular_component alt_id: GO:0008223 def: "Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [SP_KW:KW-0282] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Flagellum is_a: GO:0042995 ! cell projection is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0019862 name: IgA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019863 name: IgE binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019864 name: IgG binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019865 name: immunoglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin." [GOC:ma] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0019866 name: organelle inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] comment: See also the cellular component term 'outer membrane ; GO:0019867'. subset: gosubset_prok is_a: GO:0031090 ! organelle membrane is_a: GO:0044424 ! intracellular part relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0019867 name: outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] subset: gosubset_prok is_a: GO:0016020 ! membrane [Term] id: GO:0019869 name: chloride channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a chloride channel." [GOC:mah] is_a: GO:0008200 ! ion channel inhibitor activity is_a: GO:0017081 ! chloride channel regulator activity [Term] id: GO:0019870 name: potassium channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a potassium channel." [GOC:mah] is_a: GO:0008200 ! ion channel inhibitor activity is_a: GO:0015459 ! potassium channel regulator activity [Term] id: GO:0019871 name: sodium channel inhibitor activity namespace: molecular_function alt_id: GO:0019868 def: "Stops, prevents, or reduces the activity of a sodium channel." [GOC:mah] is_a: GO:0008200 ! ion channel inhibitor activity is_a: GO:0017080 ! sodium channel regulator activity [Term] id: GO:0019872 name: streptomycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [CHEBI:17076, GOC:curators] subset: gosubset_prok synonym: "streptomycin anabolism" EXACT [] synonym: "streptomycin biosynthesis" EXACT [] synonym: "streptomycin formation" EXACT [] synonym: "streptomycin synthesis" EXACT [] is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process is_a: GO:0046343 ! streptomycin metabolic process [Term] id: GO:0019873 name: tellurium sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046690 [Term] id: GO:0019874 name: 6-aminohexanoate-cyclic-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H(2)O = N-(6-aminohexanoyl)-6-aminohexanoate." [EC:3.5.2.12, RHEA:16228] subset: gosubset_prok synonym: "1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity" EXACT [EC:3.5.2.12] xref: EC:3.5.2.12 xref: KEGG:R03448 xref: MetaCyc:3.5.2.12-RXN xref: RHEA:16228 xref: UM-BBD_reactionID:r1097 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0019875 name: 6-aminohexanoate-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate." [EC:3.5.1.46] subset: gosubset_prok synonym: "6-aminohexanoic acid oligomer hydrolase activity" EXACT [EC:3.5.1.46] synonym: "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity" EXACT [EC:3.5.1.46] xref: EC:3.5.1.46 xref: MetaCyc:RXN-3962 xref: UM-BBD_enzymeID:e0673 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0019876 name: nylon catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [SP_KW:KW-0549] subset: gosubset_prok synonym: "nylon breakdown" EXACT [] synonym: "nylon catabolism" EXACT [] synonym: "nylon degradation" EXACT [] is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042198 ! nylon metabolic process [Term] id: GO:0019877 name: diaminopimelate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ma, ISBN:0198547684] subset: gosubset_prok synonym: "diaminopimelate anabolism" EXACT [] synonym: "diaminopimelate biosynthesis" EXACT [] synonym: "diaminopimelate formation" EXACT [] synonym: "diaminopimelate synthesis" EXACT [] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046451 ! diaminopimelate metabolic process relationship: part_of GO:0009089 ! lysine biosynthetic process via diaminopimelate [Term] id: GO:0019878 name: lysine biosynthetic process via aminoadipic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators] subset: gosubset_prok synonym: "lysine anabolism via aminoadipic acid" EXACT [] synonym: "lysine biosynthesis, aminoadipic acid pathway" EXACT [] synonym: "lysine biosynthesis, aminoadipic pathway" EXACT [] synonym: "lysine biosynthetic process, aminoadipic acid pathway" EXACT [] synonym: "lysine biosynthetic process, aminoadipic pathway" EXACT [] synonym: "lysine formation via aminoadipic acid" EXACT [] synonym: "lysine synthesis via aminoadipic acid" EXACT [] is_a: GO:0009085 ! lysine biosynthetic process [Term] id: GO:0019879 name: peptidyl-thyronine biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine." [GOC:jsg] comment: See also the biological process term 'peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine ; GO:0018250'. subset: gosubset_prok synonym: "peptidyl-thyronine anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-thyronine formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-thyronine synthesis from peptidyl-tyrosine" EXACT [] is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0019880 name: bacteriocin susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046678 [Term] id: GO:0019881 name: streptomycin susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046679 [Term] id: GO:0019882 name: antigen processing and presentation namespace: biological_process alt_id: GO:0030333 def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678] comment: This term was improved by GO_REF:0000022. It was renamed and redefined. synonym: "antigen presentation" EXACT [] synonym: "antigen processing" EXACT [] xref: Wikipedia:Antigen_presentation is_a: GO:0002376 ! immune system process [Term] id: GO:0019883 name: antigen processing and presentation of endogenous antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678] synonym: "antigen presentation, endogenous antigen" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0019884 name: antigen processing and presentation of exogenous antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678] synonym: "antigen presentation, exogenous antigen" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0019885 name: antigen processing and presentation of endogenous peptide antigen via MHC class I namespace: biological_process alt_id: GO:0048004 def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "antigen presentation, endogenous peptide antigen" BROAD [] synonym: "antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD [] synonym: "antigen processing, endogenous antigen via MHC class I" BROAD [] synonym: "endogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen [Term] id: GO:0019886 name: antigen processing and presentation of exogenous peptide antigen via MHC class II namespace: biological_process alt_id: GO:0042591 alt_id: GO:0048005 def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "antigen presentation, exogenous antigen via MHC class II" BROAD [] synonym: "antigen presentation, exogenous peptide antigen" BROAD [] synonym: "antigen processing, exogenous antigen via major histocompatibility complex class II" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0019887 name: protein kinase regulator activity namespace: molecular_function def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0019207 ! kinase regulator activity [Term] id: GO:0019888 name: protein phosphatase regulator activity namespace: molecular_function def: "Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [GOC:ai] is_a: GO:0019208 ! phosphatase regulator activity [Term] id: GO:0019889 name: pteridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pteridine metabolism" EXACT [] is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0019893 name: DNA replication inhibitor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. is_obsolete: true replaced_by: GO:0008156 [Term] id: GO:0019894 name: kinesin binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0019895 name: kinesin-associated mitochondrial adaptor activity namespace: molecular_function def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria." [PMID:12495622] is_a: GO:0019894 ! kinesin binding is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0019896 name: axon transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai] synonym: "axon transport of mitochondria" EXACT [] is_a: GO:0008088 ! axon cargo transport [Term] id: GO:0019897 name: extrinsic to plasma membrane namespace: cellular_component alt_id: GO:0000157 def: "Loosely bound to one surface of the plasma membrane, but not integrated into the hydrophobic region." [GOC:curators] subset: gosubset_prok synonym: "juxtamembrane" BROAD [] synonym: "peripheral plasma membrane protein" EXACT [] is_a: GO:0019898 ! extrinsic to membrane is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0019898 name: extrinsic to membrane namespace: cellular_component alt_id: GO:0030396 def: "Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah] comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions. subset: gosubset_prok synonym: "peripheral membrane protein" EXACT [] xref: Wikipedia:Peripheral_membrane_protein is_a: GO:0044425 ! membrane part [Term] id: GO:0019899 name: enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with any enzyme." [GOC:jl] subset: gosubset_prok is_a: GO:0005515 ! protein binding [Term] id: GO:0019900 name: kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0019901 name: protein kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] is_a: GO:0019900 ! kinase binding [Term] id: GO:0019902 name: phosphatase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any phosphatase." [GOC:jl] subset: gosubset_prok is_a: GO:0019899 ! enzyme binding [Term] id: GO:0019903 name: protein phosphatase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein phosphatase." [GOC:jl] subset: gosubset_prok is_a: GO:0019902 ! phosphatase binding [Term] id: GO:0019904 name: protein domain specific binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators] subset: gosubset_prok synonym: "protein domain-specific binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019905 name: syntaxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0000149 ! SNARE binding [Term] id: GO:0019907 name: cyclin-dependent protein kinase activating kinase holoenzyme complex namespace: cellular_component def: "A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor." [GOC:mah, PMID:8752210] synonym: "CAK complex" EXACT [] synonym: "CDK-activating kinase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0019908 name: nuclear cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0019909 name: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity namespace: molecular_function def: "Modification of the activity of the enzyme [pyruvate dehydrogenase (lipoamide)] phosphatase." [EC:3.1.3.43, GOC:ai] synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0019910 name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus." [GOC:mtg_sensu, PMID:9395502] comment: See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'. is_a: GO:0044429 ! mitochondrial part is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0019911 name: structural constituent of myelin sheath namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0019912 name: cyclin-dependent protein kinase activating kinase activity namespace: molecular_function alt_id: GO:0019913 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators] synonym: "CAK" EXACT [] synonym: "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity" EXACT [] xref: EC:2.7.11.- is_a: GO:0004672 ! protein kinase activity is_a: GO:0030295 ! protein kinase activator activity [Term] id: GO:0019914 name: cyclin-dependent protein kinase activating kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai] synonym: "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity" NARROW [] xref: EC:2.7.1.- is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0019915 name: lipid storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] synonym: "lipid retention" EXACT [GOC:dph, GOC:tb] synonym: "lipid sequestering" NARROW [GOC:dph, GOC:tb] synonym: "lipid sequestration" NARROW [GOC:dph, GOC:tb] synonym: "retention of lipids" EXACT [GOC:dph, GOC:tb] synonym: "sequestering of lipids" NARROW [GOC:dph, GOC:tb] synonym: "sequestration of lipid" NARROW [GOC:dph, GOC:tb] synonym: "sequestration of lipids" EXACT [GOC:dph, GOC:tb] synonym: "storage of lipids" EXACT [] is_a: GO:0010876 ! lipid localization [Term] id: GO:0019916 name: peptidyl-D-alanine racemization, direct namespace: biological_process def: "The racemization of peptidyl-alanine." [RESID:AA0191] subset: gosubset_prok xref: RESID:AA0191 is_a: GO:0019122 ! peptidyl-D-alanine racemization [Term] id: GO:0019917 name: peptidyl-D-alanine racemization via peptidyl-L-serine namespace: biological_process def: "The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine." [RESID:AA0191] subset: gosubset_prok xref: RESID:AA0191 is_a: GO:0019122 ! peptidyl-D-alanine racemization [Term] id: GO:0019918 name: peptidyl-arginine methylation, to symmetrical-dimethyl arginine namespace: biological_process def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine." [RESID:AA0067, RESID:AA0069] subset: gosubset_prok xref: RESID:AA0067 xref: RESID:AA0069 is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation [Term] id: GO:0019919 name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine namespace: biological_process def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069] subset: gosubset_prok synonym: "peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine" EXACT [] xref: RESID:AA0068 xref: RESID:AA0069 is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation [Term] id: GO:0019920 name: peptidyl-1-thioglycine biosynthetic process, internal namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] subset: gosubset_prok synonym: "peptidyl-1-thioglycine anabolism, internal" EXACT [] synonym: "peptidyl-1-thioglycine formation, internal" EXACT [] synonym: "peptidyl-1-thioglycine synthesis, internal" EXACT [] xref: RESID:AA0265 is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine [Term] id: GO:0019921 name: peptidyl-1-thioglycine biosynthetic process, carboxy-terminal namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] subset: gosubset_prok synonym: "peptidyl-1-thioglycine anabolism, carboxy-terminal" EXACT [] synonym: "peptidyl-1-thioglycine formation, carboxy-terminal" EXACT [] synonym: "peptidyl-1-thioglycine synthesis, carboxy-terminal" EXACT [] xref: RESID:AA0265 is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine [Term] id: GO:0019922 name: protein-chromophore linkage via peptidyl-cysteine namespace: biological_process def: "The covalent linking of a chromophore to a protein via peptidyl-cysteines." [GOC:ma] subset: gosubset_prok is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0019923 name: alpha-1-microglobulin-chromophore linkage namespace: biological_process def: "The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds." [RESID:AA0224] subset: gosubset_prok xref: RESID:AA0224 is_a: GO:0019922 ! protein-chromophore linkage via peptidyl-cysteine [Term] id: GO:0019926 name: peptidyl-tryptophan oxidation to tryptophyl quinone namespace: biological_process def: "The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine." [PMID:2028257, RESID:AA0148] comment: See also the biological process term 'peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone ; GO:0018069'. subset: gosubset_prok is_a: GO:0018158 ! protein oxidation is_a: GO:0018211 ! peptidyl-tryptophan modification relationship: part_of GO:0018069 ! peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone [Term] id: GO:0019927 name: peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone namespace: biological_process def: "The cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0313] subset: gosubset_prok xref: RESID:AA0313 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0019928 name: peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid namespace: biological_process def: "The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0314] subset: gosubset_prok xref: RESID:AA0314 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0019929 name: peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid namespace: biological_process def: "The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid." [RESID:AA0315] subset: gosubset_prok xref: RESID:AA0315 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0019930 name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid namespace: biological_process def: "The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1." [RESID:AA0316] subset: gosubset_prok synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid" EXACT [] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid" EXACT [] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid" EXACT [] xref: RESID:AA0316 is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0019931 name: protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine." [RESID:AA0312] subset: gosubset_prok xref: RESID:AA0312 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0019932 name: second-messenger-mediated signaling namespace: biological_process def: "A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell." [GOC:mah, ISBN:0815316194] subset: gosubset_prok synonym: "second messenger mediated signaling" EXACT [] synonym: "second messenger mediated signalling" EXACT [] synonym: "second messenger-mediated signaling" EXACT [] synonym: "second messenger-mediated signalling" EXACT [] synonym: "second-messenger-mediated signalling" EXACT [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0019933 name: cAMP-mediated signaling namespace: biological_process def: "A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:mah] synonym: "3',5' cAMP-mediated signaling" EXACT [] synonym: "3',5' cAMP-mediated signalling" EXACT [] synonym: "3',5'-cAMP-mediated signaling" EXACT [] synonym: "3',5'-cAMP-mediated signalling" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-mediated signalling" EXACT [] synonym: "cAMP signaling" EXACT [] synonym: "cAMP signalling" EXACT [] synonym: "cAMP-mediated signal transduction" EXACT [] synonym: "cAMP-mediated signalling" EXACT [] synonym: "cyclic AMP-mediated signaling" EXACT [] synonym: "cyclic AMP-mediated signalling" EXACT [] is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling [Term] id: GO:0019934 name: cGMP-mediated signaling namespace: biological_process def: "A series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:mah] synonym: "cGMP-mediated signalling" EXACT [] is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling [Term] id: GO:0019935 name: cyclic-nucleotide-mediated signaling namespace: biological_process def: "A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response." [GOC:ceb] subset: gosubset_prok synonym: "cyclic-nucleotide-mediated signalling" EXACT [] is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0019936 name: inositol phospholipid-mediated signaling namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ceb] comment: This term was made obsolete because it did not adequately describe phosphoinositide-mediated signaling. synonym: "inositol phospholipid-mediated signalling" EXACT [] is_obsolete: true consider: GO:0048015 consider: GO:0048016 consider: GO:0048017 [Term] id: GO:0019937 name: protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic namespace: biological_process def: "The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid." [RESID:AA0294] subset: gosubset_prok xref: RESID:AA0294 is_a: GO:0018419 ! protein catenane formation is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine [Term] id: GO:0019938 name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic namespace: biological_process alt_id: GO:0042266 def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions." [RESID:AA0294] subset: gosubset_prok xref: RESID:AA0294 is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine [Term] id: GO:0019939 name: peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically." [RESID:AA0308] subset: gosubset_prok synonym: "peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0308 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0045234 ! protein palmitoleylation [Term] id: GO:0019940 name: SUMO-dependent protein catabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not reflect an accurate biological process, as sumoylation of a protein does not lead to catabolism of that protein. synonym: "SUMO-dependent protein breakdown" EXACT [] synonym: "SUMO-dependent protein catabolism" EXACT [] synonym: "SUMO-dependent protein degradation" EXACT [] is_obsolete: true consider: GO:0016925 consider: GO:0016926 [Term] id: GO:0019941 name: modification-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] subset: gosubset_prok synonym: "modification-dependent protein breakdown" EXACT [] synonym: "modification-dependent protein catabolism" EXACT [] synonym: "modification-dependent protein degradation" EXACT [] synonym: "modification-dependent proteolysis" EXACT [GOC:rl] synonym: "modification-initiated protein catabolic process" EXACT [GOC:rl] synonym: "modification-initiated protein catabolism" EXACT [GOC:rl] synonym: "modification-initiated proteolysis" EXACT [GOC:rl] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein-ligand-dependent protein catabolic process" NARROW [] synonym: "protein-ligand-dependent protein catabolism" NARROW [] is_a: GO:0043632 ! modification-dependent macromolecule catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0019942 name: NEDD8 class-dependent protein catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein." [GOC:jl] comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction. synonym: "NEDD8 class-dependent protein breakdown" EXACT [] synonym: "NEDD8 class-dependent protein catabolism" EXACT [] synonym: "NEDD8 class-dependent protein degradation" EXACT [] synonym: "RUB1-dependent protein catabolic process" EXACT [] synonym: "RUB1-dependent protein catabolism" EXACT [] synonym: "RUB1-dependent protein degradation" EXACT [] is_obsolete: true consider: GO:0045116 [Term] id: GO:0019948 name: SUMO activating enzyme activity namespace: molecular_function alt_id: GO:0017115 def: "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250] synonym: "SMT3 activating enzyme" EXACT [] synonym: "SUMO E1 activator enzyme" EXACT [] is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0019950 name: SMT3-dependent protein catabolic process namespace: biological_process alt_id: GO:0019946 def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein." [GOC:jl, PMID:9435231] synonym: "SMT3-dependent protein breakdown" EXACT [] synonym: "SMT3-dependent protein catabolism" EXACT [] synonym: "SMT3-dependent protein degradation" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0019951 name: Smt3-protein conjugation namespace: biological_process alt_id: GO:0019947 def: "The covalent addition to a protein of Smt3, a ubiquitin-like protein." [GOC:jl] synonym: "Smt3p-protein conjugation" EXACT [] is_a: GO:0032446 ! protein modification by small protein conjugation relationship: part_of GO:0019950 ! SMT3-dependent protein catabolic process [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times." [ISBN:0387520546] xref: Wikipedia:Sexual_reproduction is_a: GO:0000003 ! reproduction [Term] id: GO:0019954 name: asexual reproduction namespace: biological_process def: "The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process." [ISBN:0387520546] subset: gosubset_prok xref: Wikipedia:Asexual_reproduction is_a: GO:0000003 ! reproduction [Term] id: GO:0019955 name: cytokine binding namespace: molecular_function alt_id: GO:0019965 def: "Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] synonym: "IL binding" NARROW [] synonym: "interleukin binding" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019956 name: chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chemokine, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [GOC:ai] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019957 name: C-C chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] is_a: GO:0019956 ! chemokine binding [Term] id: GO:0019958 name: C-X-C chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:ai] is_a: GO:0019956 ! chemokine binding [Term] id: GO:0019959 name: interleukin-8 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-8." [GOC:jl] synonym: "IL-8 binding" EXACT [] is_a: GO:0019958 ! C-X-C chemokine binding [Term] id: GO:0019960 name: C-X3-C chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] is_a: GO:0019956 ! chemokine binding [Term] id: GO:0019961 name: interferon binding namespace: molecular_function def: "Interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent." [Wikipedia:Interferon] synonym: "IFN binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019962 name: type I interferon binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon-alpha binding" NARROW [] synonym: "interferon-alpha/beta binding" NARROW [] synonym: "interferon-beta binding" NARROW [] synonym: "interferon-delta binding" NARROW [] synonym: "interferon-epsilon binding" NARROW [] synonym: "interferon-kappa binding" NARROW [] synonym: "interferon-omega binding" NARROW [] synonym: "interferon-tau binding" NARROW [] synonym: "interferon-zeta binding" NARROW [] synonym: "type I IFN binding" EXACT [GOC:mah] is_a: GO:0019961 ! interferon binding [Term] id: GO:0019964 name: interferon-gamma binding namespace: molecular_function def: "Interacting selectively and non-covalently with interferon-gamma. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383] synonym: "IFN-gamma binding" EXACT [GOC:mah] synonym: "IFNG binding" EXACT [GOC:mah] synonym: "type II interferon binding" EXACT [] is_a: GO:0019961 ! interferon binding [Term] id: GO:0019966 name: interleukin-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-1." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "IL-1 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019969 name: interleukin-10 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-10." [GOC:jl] synonym: "IL-10 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019970 name: interleukin-11 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-11." [GOC:jl] synonym: "IL-11 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019972 name: interleukin-12 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-12." [GOC:jl] synonym: "IL-12 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019973 name: interleukin-13 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-13." [GOC:jl] synonym: "IL-13 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019974 name: interleukin-14 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-14." [GOC:jl] synonym: "IL-14 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019975 name: interleukin-17 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-17." [GOC:jl] synonym: "IL-17 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019976 name: interleukin-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-2." [GOC:jl] synonym: "IL-2 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019977 name: interleukin-21 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-21." [GOC:jl] synonym: "IL-21 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019978 name: interleukin-3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-3." [GOC:jl] synonym: "IL-3 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019979 name: interleukin-4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-4." [GOC:jl] synonym: "IL-4 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019980 name: interleukin-5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-5." [GOC:jl] synonym: "IL-5 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019981 name: interleukin-6 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-6." [GOC:jl] synonym: "IL-6 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019982 name: interleukin-7 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-7." [GOC:jl] synonym: "IL-7 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019983 name: interleukin-9 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-9." [GOC:jl] synonym: "IL-9 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019985 name: translesion synthesis namespace: biological_process def: "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, PMID:10535901] subset: gosubset_prok synonym: "bypass DNA synthesis" EXACT [GOC:elh] is_a: GO:0006301 ! postreplication repair is_a: GO:0071897 ! DNA biosynthetic process [Term] id: GO:0019987 name: negative regulation of anti-apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis." [GOC:go_curators] synonym: "down regulation of anti-apoptosis" EXACT [] synonym: "down-regulation of anti-apoptosis" EXACT [] synonym: "downregulation of anti-apoptosis" EXACT [] synonym: "inhibition of anti-apoptosis" NARROW [] is_a: GO:0045767 ! regulation of anti-apoptosis is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0006916 ! anti-apoptosis [Term] id: GO:0019988 name: charged-tRNA amino acid modification namespace: biological_process alt_id: GO:0030630 def: "The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine." [GOC:jsg] subset: gosubset_prok synonym: "charged tRNA amino acid modification" EXACT [] synonym: "charged tRNA modification" EXACT [] synonym: "charged-tRNA modification" RELATED [] synonym: "pre-translational amino acid modification" EXACT [] synonym: "pre-translational protein modification" EXACT [] synonym: "pretranslation protein modification" EXACT [] synonym: "pretranslational amino acid modification" EXACT [] is_a: GO:0006400 ! tRNA modification is_a: GO:0006464 ! protein modification process [Term] id: GO:0019990 name: pteridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pteridine breakdown" EXACT [] synonym: "pteridine catabolism" EXACT [] synonym: "pteridine degradation" EXACT [] is_a: GO:0019889 ! pteridine metabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process [Term] id: GO:0019991 name: septate junction assembly namespace: biological_process def: "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] is_a: GO:0007043 ! cell-cell junction assembly relationship: part_of GO:0043297 ! apical junction assembly [Term] id: GO:0019992 name: diacylglycerol binding namespace: molecular_function def: "Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma] is_a: GO:0008289 ! lipid binding [Term] id: GO:0020002 name: host cell plasma membrane namespace: cellular_component def: "The plasma membrane surrounding a host cell." [GOC:mb] subset: gosubset_prok is_a: GO:0033644 ! host cell membrane [Term] id: GO:0020003 name: symbiont-containing vacuole namespace: cellular_component def: "Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont." [GOC:jl, GOC:mb] comment: Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope. synonym: "parasitophorous vacuole" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part is_a: GO:0065010 ! extracellular membrane-bounded organelle [Term] id: GO:0020004 name: symbiont-containing vacuolar space namespace: cellular_component def: "The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane." [GOC:jl, GOC:mb] synonym: "parasitophorous vacuolar space" EXACT [] synonym: "symbiont-containing vacuole space" RELATED [] is_a: GO:0033643 ! host cell part is_a: GO:0044422 ! organelle part relationship: part_of GO:0020003 ! symbiont-containing vacuole [Term] id: GO:0020005 name: symbiont-containing vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont." [GOC:jl, GOC:mb] synonym: "parasitophorous vacuolar membrane" EXACT [] is_a: GO:0005774 ! vacuolar membrane is_a: GO:0033643 ! host cell part relationship: part_of GO:0020003 ! symbiont-containing vacuole [Term] id: GO:0020006 name: symbiont-containing vacuolar membrane network namespace: cellular_component def: "Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm." [GOC:jl, PMID:3528173] synonym: "parasitophorous vacuolar membrane network" EXACT [] synonym: "symbiont-containing vacuole membrane network" EXACT [] synonym: "tubulovesicular network" NARROW [] is_a: GO:0033643 ! host cell part is_a: GO:0044425 ! membrane part is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane [Term] id: GO:0020007 name: apical complex namespace: cellular_component def: "Protruding complex at the anterior end of some life cycle stages of all apicomplexan parasites, involved in both the attachment and penetration of the host cell by the parasite." [GOC:mb] is_a: GO:0044464 ! cell part relationship: part_of GO:0045177 ! apical part of cell [Term] id: GO:0020008 name: rhoptry namespace: cellular_component def: "A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole." [ISBN:0521664470, PMID:11801218, PMID:16002398] synonym: "paired organelles" RELATED [] synonym: "toxoneme" RELATED [] xref: Wikipedia:Rhoptry is_a: GO:0044464 ! cell part relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020009 name: microneme namespace: cellular_component def: "A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell." [ISBN:0521664470, PMID:11801218] synonym: "sarconeme" RELATED [] xref: Wikipedia:Microneme is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020010 name: conoid namespace: cellular_component def: "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules." [GOC:expert_dr, PMID:11901169, PMID:16518471] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020011 name: apicoplast namespace: cellular_component def: "The plastid organelle found in apicomplexans." [ISBN:0521664470] xref: Wikipedia:Apicoplast is_a: GO:0009536 ! plastid [Term] id: GO:0020012 name: evasion or tolerance of host immune response namespace: biological_process def: "Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] subset: gosubset_prok synonym: "immune evasion" BROAD [] is_a: GO:0030682 ! evasion or tolerance of host defense response is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction is_a: GO:0052572 ! response to host immune response [Term] id: GO:0020013 name: modulation by symbiont of host erythrocyte aggregation namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of erythrocyte aggregation in its host organism, e.g. the binding of parasite-infected erythrocytes to uninfected erythrocytes." [GOC:add, GOC:dgh, GOC:mb, GOC:pr, PMID:19467172, PMID:21305024] comment: Please note that this term does not refer to the in vitro assay called erythrocyte rosetting. synonym: "rosetting" EXACT [] xref: Wikipedia:Rosetting is_a: GO:0034118 ! regulation of erythrocyte aggregation is_a: GO:0044068 ! modulation by symbiont of host cellular process [Term] id: GO:0020014 name: schizogony namespace: biological_process def: "Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously." [GOC:mb] xref: Wikipedia:Protozoal_merogony is_a: GO:0051301 ! cell division [Term] id: GO:0020015 name: glycosome namespace: cellular_component def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb] subset: goslim_pir xref: Wikipedia:Glycosome is_a: GO:0005777 ! peroxisome [Term] id: GO:0020016 name: flagellar pocket namespace: cellular_component def: "Invagination of the plasma membrane from which a flagellum protrudes." [GOC:mb] is_a: GO:0044442 ! microtubule-based flagellum part [Term] id: GO:0020017 name: flagellar membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the flagellum." [GOC:mah, GOC:mb] is_a: GO:0031090 ! organelle membrane is_a: GO:0031253 ! cell projection membrane is_a: GO:0044442 ! microtubule-based flagellum part [Term] id: GO:0020018 name: flagellar pocket membrane namespace: cellular_component def: "That part of the plasma membrane found in the flagellar pocket." [GOC:mb] is_a: GO:0020017 ! flagellar membrane relationship: part_of GO:0020016 ! flagellar pocket [Term] id: GO:0020020 name: food vacuole namespace: cellular_component alt_id: GO:0005772 def: "Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa." [GOC:mb] synonym: "digestive vacuole" EXACT [] is_a: GO:0032010 ! phagolysosome [Term] id: GO:0020021 name: immortalization of host cell namespace: biological_process def: "The modification of a host cell into an immortal cell line as a consequence of infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] synonym: "host cell immortalization" EXACT [] synonym: "host cell transformation" EXACT [] synonym: "transformation of host cell" EXACT [] is_a: GO:0051701 ! interaction with host [Term] id: GO:0020022 name: acidocalcisome namespace: cellular_component def: "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb] subset: goslim_pir synonym: "metachromatic granule" EXACT [PMID:15738951] synonym: "polyphosphate vacuole" RELATED [PMID:15738951] synonym: "volutin granule" EXACT [PMID:15738951] is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0020023 name: kinetoplast namespace: cellular_component def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb] xref: Wikipedia:Kinetoplast is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0020025 name: subpellicular microtubule namespace: cellular_component def: "Singlet microtubules that lie underneath the inner membrane complex and emanate from the basal ring of the conoid." [GOC:mb] is_a: GO:0005874 ! microtubule relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020026 name: merozoite dense granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell." [GOC:mb, GOC:mtg_sensu] synonym: "dense body" EXACT [] is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0020027 name: hemoglobin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization." [GOC:go_curators, GOC:jl] synonym: "haemoglobin metabolic process" EXACT [] synonym: "haemoglobin metabolism" EXACT [] synonym: "hemoglobin metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0020028 name: hemoglobin import namespace: biological_process def: "The directed movement into a tissue, cell or organelle of externally available hemoglobin." [GOC:mb] synonym: "haemoglobin uptake" EXACT [] synonym: "hemoglobin uptake" EXACT [] is_a: GO:0017038 ! protein import [Term] id: GO:0020030 name: infected host cell surface knob namespace: cellular_component def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species." [GOC:mb] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0020031 name: polar ring of apical complex namespace: cellular_component def: "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mb, PMID:16518471] synonym: "anterior polar ring of apical complex" EXACT [] synonym: "upper polar ring of apical complex" EXACT [] is_a: GO:0044464 ! cell part relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020032 name: basal ring of apical complex namespace: cellular_component def: "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mah, PMID:16518471] synonym: "lower polar ring of apical complex" EXACT [] synonym: "posterior polar ring of apical complex" EXACT [] synonym: "preconoidal ring of apical complex" EXACT [] is_a: GO:0044464 ! cell part relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020033 name: antigenic variation namespace: biological_process alt_id: GO:0020034 def: "Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system." [GOC:mb] subset: gosubset_prok synonym: "surface antigen variation" NARROW [] xref: Wikipedia:Antigenic_variation is_a: GO:0051809 ! passive evasion of immune response of other organism involved in symbiotic interaction [Term] id: GO:0020035 name: cytoadherence to microvasculature, mediated by symbiont protein namespace: biological_process def: "The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte." [GOC:mb] synonym: "cytoadherence to microvasculature, mediated by parasite protein" NARROW [] synonym: "cytoadherence to microvasculature, mediated by symbiont protein" BROAD [] synonym: "parasite-protein-mediated cytoadherence to microvasculature" EXACT [] synonym: "symbiont-protein-mediated cytoadherence to microvasculature" BROAD [] is_a: GO:0044406 ! adhesion to host [Term] id: GO:0020036 name: Maurer's cleft namespace: cellular_component def: "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton." [PMID:16705161] synonym: "Maurers cleft" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0020037 name: heme binding namespace: molecular_function def: "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] subset: gosubset_prok synonym: "haem binding" EXACT [] is_a: GO:0005506 ! iron ion binding is_a: GO:0046906 ! tetrapyrrole binding [Term] id: GO:0020038 name: subpellicular network namespace: cellular_component def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0020039 ! pellicle [Term] id: GO:0020039 name: pellicle namespace: cellular_component def: "The structure enclosing an apicomplexan parasite cell; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mah, GOC:mb] is_a: GO:0044464 ! cell part [Term] id: GO:0021501 name: prechordal plate formation namespace: biological_process def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0021502 name: neural fold elevation formation namespace: biological_process def: "The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001842 ! neural fold formation [Term] id: GO:0021503 name: neural fold bending namespace: biological_process def: "The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0001842 ! neural fold formation [Term] id: GO:0021504 name: neural fold hinge point formation namespace: biological_process def: "The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] comment: This term was added by GO_REF:0000021. synonym: "neural fold furrowing" NARROW [GOC:cls] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021503 ! neural fold bending [Term] id: GO:0021505 name: neural fold folding namespace: biological_process def: "The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0021503 ! neural fold bending [Term] id: GO:0021506 name: anterior neuropore closure namespace: biological_process def: "The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0021995 ! neuropore closure [Term] id: GO:0021507 name: posterior neuropore closure namespace: biological_process def: "The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0060608 ! cell-cell adhesion involved in neural tube closure relationship: part_of GO:0021995 ! neuropore closure [Term] id: GO:0021508 name: floor plate formation namespace: biological_process def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007418 ! ventral midline development relationship: part_of GO:0033505 ! floor plate morphogenesis [Term] id: GO:0021509 name: roof plate formation namespace: biological_process def: "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15936325] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0021510 name: spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021511 name: spinal cord patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021512 name: spinal cord anterior/posterior patterning namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "spinal cord anterior-posterior patterning" EXACT [] synonym: "spinal cord rostrocaudal patterning" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0021511 ! spinal cord patterning [Term] id: GO:0021513 name: spinal cord dorsal/ventral patterning namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "spinal cord dorsal-ventral patterning" EXACT [] synonym: "spinal cord dorsoventral patterning" EXACT [GOC:mah] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0021511 ! spinal cord patterning [Term] id: GO:0021514 name: ventral spinal cord interneuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021517 ! ventral spinal cord development [Term] id: GO:0021515 name: cell differentiation in spinal cord namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021516 name: dorsal spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11179871] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021517 name: ventral spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021518 name: spinal cord commissural neuron specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0021528 ! commissural neuron differentiation in spinal cord [Term] id: GO:0021519 name: spinal cord association neuron specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0021527 ! spinal cord association neuron differentiation [Term] id: GO:0021520 name: spinal cord motor neuron cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0021522 ! spinal cord motor neuron differentiation [Term] id: GO:0021521 name: ventral spinal cord interneuron specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment [Term] id: GO:0021522 name: spinal cord motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021517 ! ventral spinal cord development [Term] id: GO:0021523 name: somatic motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021522 ! spinal cord motor neuron differentiation [Term] id: GO:0021524 name: visceral motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021522 ! spinal cord motor neuron differentiation [Term] id: GO:0021525 name: lateral motor column neuron differentiation namespace: biological_process def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0021523 ! somatic motor neuron differentiation [Term] id: GO:0021526 name: medial motor column neuron differentiation namespace: biological_process def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0021523 ! somatic motor neuron differentiation [Term] id: GO:0021527 name: spinal cord association neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "spinal cord dorsal interneuron differentiation" EXACT [GOC:dph] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021516 ! dorsal spinal cord development [Term] id: GO:0021528 name: commissural neuron differentiation in spinal cord namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation [Term] id: GO:0021529 name: spinal cord oligodendrocyte cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0021530 name: spinal cord oligodendrocyte cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021778 ! oligodendrocyte cell fate specification relationship: part_of GO:0021529 ! spinal cord oligodendrocyte cell differentiation [Term] id: GO:0021531 name: spinal cord radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16185248] comment: This term was added by GO_REF:0000021. synonym: "radial glial cell differentiation in spinal cord" EXACT [GOC:curators] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0060019 ! radial glial cell differentiation [Term] id: GO:0021532 name: neural tube patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0021533 name: cell differentiation in hindbrain namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021534 name: cell proliferation in hindbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021535 name: cell migration in hindbrain namespace: biological_process def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016477 ! cell migration relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021536 name: diencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021537 name: telencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021538 name: epithalamus development namespace: biological_process def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021539 name: subthalamus development namespace: biological_process def: "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "ventral thalamus development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021540 name: corpus callosum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis relationship: part_of GO:0022038 ! corpus callosum development [Term] id: GO:0021541 name: ammon gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "Ammon's horn development" RELATED [GOC:cls] synonym: "cornu ammonis development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021766 ! hippocampus development [Term] id: GO:0021542 name: dentate gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021766 ! hippocampus development [Term] id: GO:0021543 name: pallium development namespace: biological_process def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021544 name: subpallium development namespace: biological_process def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021545 name: cranial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0021675 ! nerve development [Term] id: GO:0021546 name: rhombomere development namespace: biological_process def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021547 name: midbrain-hindbrain boundary initiation namespace: biological_process def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus biosynthesis" RELATED [GOC:cls] synonym: "isthmus formation" RELATED [GOC:cls] synonym: "MHB biosynthesis" EXACT [GOC:cls] synonym: "MHB formation" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls] is_a: GO:0003002 ! regionalization relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development [Term] id: GO:0021548 name: pons development namespace: biological_process def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0022037 ! metencephalon development [Term] id: GO:0021549 name: cerebellum development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0022037 ! metencephalon development [Term] id: GO:0021550 name: medulla oblongata development namespace: biological_process def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla development" RELATED [GOC:cls] synonym: "myelencephalon development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021551 name: central nervous system morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021552 name: midbrain-hindbrain boundary structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus structural organization" RELATED [GOC:cls] synonym: "MHB structural organization" EXACT [GOC:cls] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021555 ! midbrain-hindbrain boundary morphogenesis [Term] id: GO:0021553 name: olfactory nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN 1 development" RELATED [GOC:cls] synonym: "cranial nerve 1 development" EXACT [GOC:cls] synonym: "cranial nerve I development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021554 name: optic nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II development" RELATED [GOC:cls] synonym: "cranial nerve 2 development" EXACT [GOC:cls] synonym: "cranial nerve II development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021555 name: midbrain-hindbrain boundary morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus morphogenesis" EXACT [GOC:cls] synonym: "MHB morphogenesis" EXACT [GOC:cls] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development [Term] id: GO:0021556 name: central nervous system formation namespace: biological_process def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021551 ! central nervous system morphogenesis [Term] id: GO:0021557 name: oculomotor nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III development" RELATED [GOC:cls] synonym: "cranial nerve 3 development" EXACT [GOC:cls] synonym: "cranial nerve III development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0021783 ! preganglionic parasympathetic nervous system development [Term] id: GO:0021558 name: trochlear nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV development" RELATED [GOC:cls] synonym: "cranial nerve 4 development" EXACT [GOC:cls] synonym: "cranial nerve IV development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021559 name: trigeminal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V development" RELATED [GOC:cls] synonym: "cranial nerve 5 development" EXACT [GOC:cls] synonym: "cranial nerve V development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021560 name: abducens nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI development" RELATED [GOC:cls] synonym: "cranial nerve 6 development" EXACT [GOC:cls] synonym: "cranial nerve VI development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021561 name: facial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII development" RELATED [GOC:cls] synonym: "cranial nerve 7 development" EXACT [GOC:cls] synonym: "cranial nerve VII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0021783 ! preganglionic parasympathetic nervous system development [Term] id: GO:0021562 name: vestibulocochlear nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "acoustic nerve development" EXACT [PMID:11533729] synonym: "CN VIII development" EXACT [GOC:cls] synonym: "cranial nerve 8 development" EXACT [GOC:cls] synonym: "cranial nerve VIII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021563 name: glossopharyngeal nerve development namespace: biological_process def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX development" RELATED [GOC:cls] synonym: "cranial nerve 9 development" EXACT [GOC:cls] synonym: "cranial nerve IX development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021564 name: vagus nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X development" RELATED [GOC:cls] synonym: "cranial nerve 10 development" RELATED [GOC:cls] synonym: "cranial nerve X development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0021783 ! preganglionic parasympathetic nervous system development [Term] id: GO:0021565 name: accessory nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI development" RELATED [GOC:cls] synonym: "cranial nerve 11 development" RELATED [GOC:cls] synonym: "cranial nerve XI development" EXACT [GOC:cls] synonym: "spinal accessory nerve development" EXACT [PMID:11533729] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021566 name: hypoglossal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII development" RELATED [GOC:cls] synonym: "cranial nerve 12 development" RELATED [GOC:cls] synonym: "cranial nerve XII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021567 name: rhombomere 1 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021568 name: rhombomere 2 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021569 name: rhombomere 3 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021570 name: rhombomere 4 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021571 name: rhombomere 5 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021572 name: rhombomere 6 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021573 name: rhombomere 7 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021574 name: rhombomere 8 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021575 name: hindbrain morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "rhombencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021576 name: hindbrain formation namespace: biological_process def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021577 name: hindbrain structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021578 name: hindbrain maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021626 ! central nervous system maturation relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021579 name: medulla oblongata morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla morphogenesis" RELATED [] synonym: "myelencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021550 ! medulla oblongata development relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021580 name: medulla oblongata formation namespace: biological_process def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla biosynthesis" RELATED [] synonym: "medulla formation" RELATED [] synonym: "myelencephalon biosynthesis" RELATED [] synonym: "myelencephalon formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021579 ! medulla oblongata morphogenesis [Term] id: GO:0021581 name: medulla oblongata structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla structural maturation" RELATED [] synonym: "myelencephalon structural maturation" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021577 ! hindbrain structural organization relationship: part_of GO:0021579 ! medulla oblongata morphogenesis [Term] id: GO:0021582 name: medulla oblongata maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla maturation" RELATED [] synonym: "myelencephalon maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021550 ! medulla oblongata development relationship: part_of GO:0021578 ! hindbrain maturation [Term] id: GO:0021583 name: pons morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021584 name: pons formation namespace: biological_process def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021583 ! pons morphogenesis [Term] id: GO:0021585 name: pons structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021577 ! hindbrain structural organization relationship: part_of GO:0021583 ! pons morphogenesis [Term] id: GO:0021586 name: pons maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021578 ! hindbrain maturation [Term] id: GO:0021587 name: cerebellum morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021549 ! cerebellum development relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021588 name: cerebellum formation namespace: biological_process def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021587 ! cerebellum morphogenesis [Term] id: GO:0021589 name: cerebellum structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021577 ! hindbrain structural organization relationship: part_of GO:0021587 ! cerebellum morphogenesis [Term] id: GO:0021590 name: cerebellum maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021549 ! cerebellum development relationship: part_of GO:0021578 ! hindbrain maturation [Term] id: GO:0021591 name: ventricular system development namespace: biological_process def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0021592 name: fourth ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0683400078] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021591 ! ventricular system development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021593 name: rhombomere morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0021594 name: rhombomere formation namespace: biological_process def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021593 ! rhombomere morphogenesis [Term] id: GO:0021595 name: rhombomere structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021593 ! rhombomere morphogenesis [Term] id: GO:0021597 name: central nervous system structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021551 ! central nervous system morphogenesis [Term] id: GO:0021598 name: abducens nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI development" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021560 ! abducens nerve development [Term] id: GO:0021599 name: abducens nerve formation namespace: biological_process def: "The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI biosynthesis" RELATED [] synonym: "CN VI formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021598 ! abducens nerve morphogenesis [Term] id: GO:0021600 name: abducens nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021598 ! abducens nerve morphogenesis [Term] id: GO:0021601 name: abducens nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021560 ! abducens nerve development [Term] id: GO:0021602 name: cranial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021545 ! cranial nerve development [Term] id: GO:0021603 name: cranial nerve formation namespace: biological_process def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021602 ! cranial nerve morphogenesis [Term] id: GO:0021604 name: cranial nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021602 ! cranial nerve morphogenesis [Term] id: GO:0021605 name: cranial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0021682 ! nerve maturation relationship: part_of GO:0021545 ! cranial nerve development [Term] id: GO:0021606 name: accessory nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI maturation" RELATED [] synonym: "spinal accessory nerve maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021565 ! accessory nerve development [Term] id: GO:0021607 name: accessory nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021565 ! accessory nerve development [Term] id: GO:0021608 name: accessory nerve formation namespace: biological_process def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI biosynthesis" RELATED [] synonym: "CN XI formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021607 ! accessory nerve morphogenesis [Term] id: GO:0021609 name: accessory nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021607 ! accessory nerve morphogenesis [Term] id: GO:0021610 name: facial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021561 ! facial nerve development [Term] id: GO:0021611 name: facial nerve formation namespace: biological_process def: "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII biosynthesis" RELATED [] synonym: "CN VII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021610 ! facial nerve morphogenesis [Term] id: GO:0021612 name: facial nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021610 ! facial nerve morphogenesis [Term] id: GO:0021613 name: facial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021561 ! facial nerve development [Term] id: GO:0021614 name: glossopharyngeal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021563 ! glossopharyngeal nerve development [Term] id: GO:0021615 name: glossopharyngeal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021563 ! glossopharyngeal nerve development [Term] id: GO:0021616 name: glossopharyngeal nerve formation namespace: biological_process def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX biosynthesis" RELATED [] synonym: "CN IX formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis [Term] id: GO:0021617 name: glossopharyngeal nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis [Term] id: GO:0021618 name: hypoglossal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021566 ! hypoglossal nerve development [Term] id: GO:0021619 name: hypoglossal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021566 ! hypoglossal nerve development [Term] id: GO:0021620 name: hypoglossal nerve formation namespace: biological_process def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII biosynthesis" RELATED [] synonym: "CN XII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis [Term] id: GO:0021621 name: hypoglossal nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis [Term] id: GO:0021622 name: oculomotor nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021557 ! oculomotor nerve development [Term] id: GO:0021623 name: oculomotor nerve formation namespace: biological_process def: "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III biosynthesis" RELATED [] synonym: "CN III formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis [Term] id: GO:0021624 name: oculomotor nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis [Term] id: GO:0021625 name: oculomotor nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021557 ! oculomotor nerve development [Term] id: GO:0021626 name: central nervous system maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021627 name: olfactory nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN I morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021553 ! olfactory nerve development [Term] id: GO:0021628 name: olfactory nerve formation namespace: biological_process def: "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN I biosynthesis" RELATED [] synonym: "CN I formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021627 ! olfactory nerve morphogenesis [Term] id: GO:0021629 name: olfactory nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN I structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021627 ! olfactory nerve morphogenesis [Term] id: GO:0021630 name: olfactory nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "CN I maturation" EXACT [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021553 ! olfactory nerve development [Term] id: GO:0021631 name: optic nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021554 ! optic nerve development [Term] id: GO:0021632 name: optic nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II maturation" EXACT [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021554 ! optic nerve development [Term] id: GO:0021633 name: optic nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021631 ! optic nerve morphogenesis [Term] id: GO:0021634 name: optic nerve formation namespace: biological_process def: "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II biosynthesis" RELATED [] synonym: "CN II formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021631 ! optic nerve morphogenesis [Term] id: GO:0021635 name: trigeminal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021559 ! trigeminal nerve development [Term] id: GO:0021636 name: trigeminal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021559 ! trigeminal nerve development [Term] id: GO:0021637 name: trigeminal nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis [Term] id: GO:0021638 name: trigeminal nerve formation namespace: biological_process def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V biosynthesis" RELATED [] synonym: "CN V formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis [Term] id: GO:0021639 name: trochlear nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CH IV morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021558 ! trochlear nerve development [Term] id: GO:0021640 name: trochlear nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021558 ! trochlear nerve development [Term] id: GO:0021641 name: trochlear nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021639 ! trochlear nerve morphogenesis [Term] id: GO:0021642 name: trochlear nerve formation namespace: biological_process def: "The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV biosynthesis" RELATED [] synonym: "CN IV formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021639 ! trochlear nerve morphogenesis [Term] id: GO:0021643 name: vagus nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021564 ! vagus nerve development [Term] id: GO:0021644 name: vagus nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021564 ! vagus nerve development [Term] id: GO:0021645 name: vagus nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021644 ! vagus nerve morphogenesis [Term] id: GO:0021646 name: vagus nerve formation namespace: biological_process def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X biosynthesis" RELATED [] synonym: "CN X formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021644 ! vagus nerve morphogenesis [Term] id: GO:0021647 name: vestibulocochlear nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "auditory nerve maturation" RELATED [] synonym: "CN VIII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021562 ! vestibulocochlear nerve development [Term] id: GO:0021648 name: vestibulocochlear nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VIII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021562 ! vestibulocochlear nerve development [Term] id: GO:0021649 name: vestibulocochlear nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis [Term] id: GO:0021650 name: vestibulocochlear nerve formation namespace: biological_process def: "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII formation " RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis [Term] id: GO:0021651 name: rhombomere 1 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021567 ! rhombomere 1 development [Term] id: GO:0021652 name: rhombomere 1 formation namespace: biological_process def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis [Term] id: GO:0021653 name: rhombomere 1 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis [Term] id: GO:0021654 name: rhombomere boundary formation namespace: biological_process def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0021594 ! rhombomere formation [Term] id: GO:0021655 name: rhombomere 2 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021568 ! rhombomere 2 development [Term] id: GO:0021656 name: rhombomere 2 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis [Term] id: GO:0021657 name: rhombomere 2 formation namespace: biological_process def: "The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis [Term] id: GO:0021658 name: rhombomere 3 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021569 ! rhombomere 3 development [Term] id: GO:0021659 name: rhombomere 3 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis [Term] id: GO:0021660 name: rhombomere 3 formation namespace: biological_process def: "The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis [Term] id: GO:0021661 name: rhombomere 4 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021570 ! rhombomere 4 development [Term] id: GO:0021662 name: rhombomere 4 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis [Term] id: GO:0021663 name: rhombomere 4 formation namespace: biological_process def: "The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis [Term] id: GO:0021664 name: rhombomere 5 morphogenesis namespace: biological_process def: "The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021571 ! rhombomere 5 development [Term] id: GO:0021665 name: rhombomere 5 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis [Term] id: GO:0021666 name: rhombomere 5 formation namespace: biological_process def: "The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis [Term] id: GO:0021667 name: rhombomere 6 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021572 ! rhombomere 6 development [Term] id: GO:0021668 name: rhombomere 6 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis [Term] id: GO:0021669 name: rhombomere 6 formation namespace: biological_process def: "The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis [Term] id: GO:0021670 name: lateral ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0683400078] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development relationship: part_of GO:0021591 ! ventricular system development [Term] id: GO:0021671 name: rhombomere 7 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021573 ! rhombomere 7 development [Term] id: GO:0021672 name: rhombomere 7 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis [Term] id: GO:0021673 name: rhombomere 7 formation namespace: biological_process def: "The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis [Term] id: GO:0021674 name: rhombomere 8 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021574 ! rhombomere 8 development [Term] id: GO:0021675 name: nerve development namespace: biological_process def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0021676 name: rhombomere 8 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis [Term] id: GO:0021677 name: rhombomere 8 formation namespace: biological_process def: "The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis [Term] id: GO:0021678 name: third ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0683400078] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021591 ! ventricular system development [Term] id: GO:0021679 name: cerebellar molecular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021680 name: cerebellar Purkinje cell layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021681 name: cerebellar granular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021682 name: nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021675 ! nerve development [Term] id: GO:0021683 name: cerebellar granular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021681 ! cerebellar granular layer development relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021684 name: cerebellar granular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021685 name: cerebellar granular layer structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis relationship: part_of GO:0021698 ! cerebellar cortex structural organization [Term] id: GO:0021686 name: cerebellar granular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021681 ! cerebellar granular layer development relationship: part_of GO:0021699 ! cerebellar cortex maturation [Term] id: GO:0021687 name: cerebellar molecular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021679 ! cerebellar molecular layer development relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021688 name: cerebellar molecular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021689 name: cerebellar molecular layer structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis relationship: part_of GO:0021698 ! cerebellar cortex structural organization [Term] id: GO:0021690 name: cerebellar molecular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021679 ! cerebellar molecular layer development relationship: part_of GO:0021699 ! cerebellar cortex maturation [Term] id: GO:0021691 name: cerebellar Purkinje cell layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development relationship: part_of GO:0021699 ! cerebellar cortex maturation [Term] id: GO:0021692 name: cerebellar Purkinje cell layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021693 name: cerebellar Purkinje cell layer structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis relationship: part_of GO:0021698 ! cerebellar cortex structural organization [Term] id: GO:0021694 name: cerebellar Purkinje cell layer formation namespace: biological_process def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021695 name: cerebellar cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021696 name: cerebellar cortex morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021587 ! cerebellum morphogenesis relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021697 name: cerebellar cortex formation namespace: biological_process def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021698 name: cerebellar cortex structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021699 name: cerebellar cortex maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021590 ! cerebellum maturation relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021700 name: developmental maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. subset: goslim_generic is_a: GO:0032502 ! developmental process [Term] id: GO:0021701 name: cerebellar Golgi cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021684 ! cerebellar granular layer formation [Term] id: GO:0021702 name: cerebellar Purkinje cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation [Term] id: GO:0021703 name: locus ceruleus development namespace: biological_process def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "locus caeruleus development" EXACT [] synonym: "locus coeruleus development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021704 name: locus ceruleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021583 ! pons morphogenesis relationship: part_of GO:0021703 ! locus ceruleus development [Term] id: GO:0021705 name: locus ceruleus formation namespace: biological_process def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021704 ! locus ceruleus morphogenesis [Term] id: GO:0021706 name: locus ceruleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021586 ! pons maturation relationship: part_of GO:0021703 ! locus ceruleus development [Term] id: GO:0021707 name: cerebellar granule cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021684 ! cerebellar granular layer formation [Term] id: GO:0021708 name: Lugaro cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021709 name: cerebellar basket cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021688 ! cerebellar molecular layer formation [Term] id: GO:0021710 name: cerebellar stellate cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021688 ! cerebellar molecular layer formation [Term] id: GO:0021711 name: cerebellar unipolar brush cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021684 ! cerebellar granular layer formation [Term] id: GO:0021712 name: candelabrum cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation [Term] id: GO:0021713 name: inferior olivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive development" RELATED [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021714 name: inferior olivary nucleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021579 ! medulla oblongata morphogenesis relationship: part_of GO:0021713 ! inferior olivary nucleus development [Term] id: GO:0021715 name: inferior olivary nucleus formation namespace: biological_process def: "The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive biosynthesis" RELATED [] synonym: "inferior olive formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021580 ! medulla oblongata formation relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis [Term] id: GO:0021716 name: inferior olivary nucleus structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive structural organization" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021581 ! medulla oblongata structural organization relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis [Term] id: GO:0021717 name: inferior olivary nucleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021582 ! medulla oblongata maturation relationship: part_of GO:0021713 ! inferior olivary nucleus development [Term] id: GO:0021718 name: superior olivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olive development" RELATED [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021719 name: superior olivary nucleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olive morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021583 ! pons morphogenesis relationship: part_of GO:0021718 ! superior olivary nucleus development [Term] id: GO:0021720 name: superior olivary nucleus formation namespace: biological_process def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis [Term] id: GO:0021721 name: superior olivary nucleus structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021585 ! pons structural organization relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis [Term] id: GO:0021722 name: superior olivary nucleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olive maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021586 ! pons maturation relationship: part_of GO:0021718 ! superior olivary nucleus development [Term] id: GO:0021723 name: rhombencephalic reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the reticular formation over time, from its formation to the mature structure. The reticular formation is a series of brain nuclei located in the medulla oblongata." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021724 name: inferior raphe nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! rhombencephalic reticular formation development [Term] id: GO:0021725 name: superior raphe nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! rhombencephalic reticular formation development [Term] id: GO:0021726 name: lateral reticular nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! rhombencephalic reticular formation development [Term] id: GO:0021727 name: intermediate reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021723 ! rhombencephalic reticular formation development [Term] id: GO:0021728 name: inferior reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021723 ! rhombencephalic reticular formation development [Term] id: GO:0021729 name: superior reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021723 ! rhombencephalic reticular formation development [Term] id: GO:0021730 name: trigeminal sensory nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions from midbrain to spinal cord. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0021731 name: trigeminal motor nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021732 name: midbrain-hindbrain boundary maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus maturation" RELATED [] synonym: "MHB maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development [Term] id: GO:0021735 name: dentate nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021736 name: globose nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021737 name: emboliform nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021738 name: fastigial nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021739 name: mesencephalic trigeminal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021730 ! trigeminal sensory nucleus development [Term] id: GO:0021740 name: principal sensory nucleus of trigeminal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions. synonym: "pontine nucleus development" BROAD [GOC:dph] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021730 ! trigeminal sensory nucleus development [Term] id: GO:0021741 name: spinal trigeminal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021730 ! trigeminal sensory nucleus development [Term] id: GO:0021742 name: abducens nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021743 name: hypoglossal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021744 name: dorsal motor nucleus of vagus nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021745 name: nucleus ambiguus development namespace: biological_process def: "The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021746 name: solitary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021747 name: cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021748 name: dorsal cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021747 ! cochlear nucleus development [Term] id: GO:0021749 name: ventral cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021747 ! cochlear nucleus development [Term] id: GO:0021750 name: vestibular nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021751 name: salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021752 name: inferior salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021751 ! salivary nucleus development [Term] id: GO:0021753 name: superior salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021751 ! salivary nucleus development [Term] id: GO:0021754 name: facial nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021755 name: eurydendroid cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15892096] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021756 name: striatum development namespace: biological_process def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "neostriatum development" EXACT [] synonym: "striate nucleus development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0021757 name: caudate nucleus development namespace: biological_process def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021756 ! striatum development [Term] id: GO:0021758 name: putamen development namespace: biological_process def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021756 ! striatum development [Term] id: GO:0021759 name: globus pallidus development namespace: biological_process def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "pallidum development" EXACT [PMID:16271465] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021761 name: limbic system development namespace: biological_process def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021762 name: substantia nigra development namespace: biological_process def: "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021539 ! subthalamus development [Term] id: GO:0021763 name: subthalamic nucleus development namespace: biological_process def: "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "corpus luysi development" RELATED [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021539 ! subthalamus development [Term] id: GO:0021764 name: amygdala development namespace: biological_process def: "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021765 name: cingulate gyrus development namespace: biological_process def: "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021766 name: hippocampus development namespace: biological_process def: "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021543 ! pallium development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021767 name: mammillary body development namespace: biological_process def: "The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "mammillary body development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021768 name: nucleus accumbens development namespace: biological_process def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "accumbens nucleus development" EXACT [GOC:dgh] synonym: "ventral striatum development" BROAD [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021756 ! striatum development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021769 name: orbitofrontal cortex development namespace: biological_process def: "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021770 name: parahippocampal gyrus development namespace: biological_process def: "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "hippocampal gyrus development" EXACT [GOC:dgh] xref: Wikipedia:parahippocampal_gyrus is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021771 name: lateral geniculate nucleus development namespace: biological_process def: "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "LGN development" EXACT [GOC:dgh] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021794 ! thalamus development [Term] id: GO:0021772 name: olfactory bulb development namespace: biological_process def: "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021988 ! olfactory lobe development [Term] id: GO:0021773 name: striatal medium spiny neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0021879 ! forebrain neuron differentiation relationship: part_of GO:0021756 ! striatum development [Term] id: GO:0021774 name: retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:sdb_2009, GOC:tb, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] is_a: GO:0060895 ! retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification [Term] id: GO:0021775 name: smoothened signaling pathway involved in ventral spinal cord interneuron specification namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification [Term] id: GO:0021776 name: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15936325] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in spinal cord motor neuron cell fate specification" EXACT [] is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification [Term] id: GO:0021777 name: BMP signaling pathway involved in spinal cord association neuron specification namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. synonym: "BMP signalling pathway involved in spinal cord association neuron specification" EXACT [] synonym: "bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [] synonym: "bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [] is_a: GO:0021919 ! BMP signaling pathway involved in spinal cord dorsal/ventral patterning relationship: part_of GO:0021519 ! spinal cord association neuron specification [Term] id: GO:0021778 name: oligodendrocyte cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021780 ! glial cell fate specification relationship: part_of GO:0021779 ! oligodendrocyte cell fate commitment [Term] id: GO:0021779 name: oligodendrocyte cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021781 ! glial cell fate commitment is_a: GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0021780 name: glial cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0021781 ! glial cell fate commitment [Term] id: GO:0021781 name: glial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0010001 ! glial cell differentiation [Term] id: GO:0021782 name: glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048468 ! cell development relationship: part_of GO:0010001 ! glial cell differentiation [Term] id: GO:0021783 name: preganglionic parasympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the preganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0007417 ! central nervous system development relationship: part_of GO:0048486 ! parasympathetic nervous system development [Term] id: GO:0021784 name: postganglionic parasympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0007422 ! peripheral nervous system development relationship: part_of GO:0048486 ! parasympathetic nervous system development [Term] id: GO:0021785 name: branchiomotor neuron axon guidance namespace: biological_process def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "BMN axon guidance" EXACT [PMID:14699587] synonym: "branchial motor axon guidance" EXACT [PMID:14699587] synonym: "special visceral motor neuron axon guidance" EXACT [PMID:14699587] is_a: GO:0008045 ! motor axon guidance [Term] id: GO:0021786 name: branchiomotor neuron axon guidance in neural tube namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. is_a: GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021787 name: chemorepulsion of branchiomotor neuron axon in neural tube namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah] is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube is_a: GO:0021793 ! chemorepulsion of branchiomotor axon [Term] id: GO:0021788 name: chemoattraction of branchiomotor neuron axon in neural tube namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah] is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube is_a: GO:0021792 ! chemoattraction of branchiomotor axon [Term] id: GO:0021789 name: branchiomotor neuron axon guidance in branchial arch mesenchyme namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. is_a: GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021790 name: chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah] is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme is_a: GO:0021793 ! chemorepulsion of branchiomotor axon [Term] id: GO:0021791 name: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah] is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme is_a: GO:0021792 ! chemoattraction of branchiomotor axon [Term] id: GO:0021792 name: chemoattraction of branchiomotor axon namespace: biological_process def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis of branchiomotor axon" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis is_a: GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021793 name: chemorepulsion of branchiomotor axon namespace: biological_process def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis of branchiomotor axon" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis is_a: GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021794 name: thalamus development namespace: biological_process def: "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021795 name: cerebral cortex cell migration namespace: biological_process def: "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022029 ! telencephalon cell migration relationship: part_of GO:0021987 ! cerebral cortex development [Term] id: GO:0021796 name: cerebral cortex regionalization namespace: biological_process def: "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "cerebral cortex arealization" EXACT [] synonym: "cerebral cortex pattern biosynthesis" EXACT [] synonym: "cerebral cortex pattern formation" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0021978 ! telencephalon regionalization relationship: part_of GO:0021987 ! cerebral cortex development [Term] id: GO:0021797 name: forebrain anterior/posterior pattern formation namespace: biological_process def: "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "forebrain anterior-posterior pattern formation" EXACT [] is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0021871 ! forebrain regionalization [Term] id: GO:0021798 name: forebrain dorsal/ventral pattern formation namespace: biological_process def: "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "forebrain dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "forebrain dorsal-ventral pattern formation" EXACT [] synonym: "forebrain dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0021871 ! forebrain regionalization [Term] id: GO:0021799 name: cerebral cortex radially oriented cell migration namespace: biological_process def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021795 ! cerebral cortex cell migration [Term] id: GO:0021800 name: cerebral cortex tangential migration namespace: biological_process def: "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021795 ! cerebral cortex cell migration [Term] id: GO:0021801 name: cerebral cortex radial glia guided migration namespace: biological_process def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "glial-guided locomotion" RELATED [PMID:12626695] is_a: GO:0021799 ! cerebral cortex radially oriented cell migration [Term] id: GO:0021802 name: somal translocation namespace: biological_process def: "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "perikaryal translocation of Morest" EXACT [PMID:12626695] is_a: GO:0021799 ! cerebral cortex radially oriented cell migration [Term] id: GO:0021803 name: pial surface process extension namespace: biological_process def: "The extension of a long process to the pial surface as a cell leaves the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0030031 ! cell projection assembly relationship: part_of GO:0021802 ! somal translocation [Term] id: GO:0021804 name: negative regulation of cell adhesion in ventricular zone namespace: biological_process def: "The process that results in the loss of attachments of a cell in the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "down regulation of cell adhesion in ventricular zone" EXACT [] synonym: "down-regulation of cell adhesion in ventricular zone" EXACT [] synonym: "downregulation of cell adhesion in ventricular zone" EXACT [] synonym: "inhibition of cell adhesion in ventricular zone" NARROW [] is_a: GO:0007162 ! negative regulation of cell adhesion relationship: part_of GO:0021802 ! somal translocation [Term] id: GO:0021805 name: cell movement involved in somal translocation namespace: biological_process def: "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cell motility involved in somal translocation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility relationship: part_of GO:0021802 ! somal translocation [Term] id: GO:0021806 name: initiation of movement involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "initiation of movement involved in cerebral cortex glial-mediated radial migration" RELATED [GOC:dph] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0001667 ! ameboidal cell migration relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021807 name: motogenic signaling initiating cell movement in cerebral cortex namespace: biological_process def: "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "motogenic signalling initiating cell movement in the cerebral cortex" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration [Term] id: GO:0021808 name: cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration namespace: biological_process def: "The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration [Term] id: GO:0021809 name: neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex [Term] id: GO:0021810 name: neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex [Term] id: GO:0021811 name: growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:mtg_cardio] synonym: "growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [] is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex [Term] id: GO:0021812 name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration [Term] id: GO:0021813 name: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration [Term] id: GO:0021814 name: cell motility involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph] is_a: GO:0048870 ! cell motility relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration [Term] id: GO:0021815 name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021816 name: extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration namespace: biological_process def: "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0031269 ! pseudopodium assembly relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [Term] id: GO:0021817 name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration namespace: biological_process def: "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] is_a: GO:0030473 ! nuclear migration along microtubule relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [Term] id: GO:0021818 name: modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration namespace: biological_process def: "The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0030036 ! actin cytoskeleton organization relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021819 name: layer formation in cerebral cortex namespace: biological_process def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cerebral cortex lamination" RELATED [PMID:12626695] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration [Term] id: GO:0021820 name: extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0030198 ! extracellular matrix organization relationship: part_of GO:0021819 ! layer formation in cerebral cortex [Term] id: GO:0021821 name: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination namespace: biological_process def: "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "down regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] synonym: "down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] synonym: "downregulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] synonym: "inhibition of cell-glial cell adhesion involved in cerebral cortex lamination" NARROW [] is_a: GO:0022408 ! negative regulation of cell-cell adhesion relationship: part_of GO:0021819 ! layer formation in cerebral cortex [Term] id: GO:0021822 name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW [] synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0051960 ! regulation of nervous system development relationship: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration relationship: part_of GO:0021819 ! layer formation in cerebral cortex [Term] id: GO:0021823 name: cerebral cortex tangential migration using cell-cell interactions namespace: biological_process def: "The process in which neurons interact with each other to promote migration along a tangential plane." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "chain migration" RELATED [PMID:12626695] is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration [Term] id: GO:0021824 name: cerebral cortex tangential migration using cell-axon interactions namespace: biological_process def: "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration [Term] id: GO:0021825 name: substrate-dependent cerebral cortex tangential migration namespace: biological_process def: "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0006929 ! substrate-dependent cell migration is_a: GO:0021800 ! cerebral cortex tangential migration [Term] id: GO:0021826 name: substrate-independent telencephalic tangential migration namespace: biological_process def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0022029 ! telencephalon cell migration [Term] id: GO:0021827 name: postnatal olfactory bulb interneuron migration namespace: biological_process def: "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb relationship: part_of GO:0021891 ! olfactory bulb interneuron development [Term] id: GO:0021828 name: gonadotrophin-releasing hormone neuronal migration to the hypothalamus namespace: biological_process alt_id: GO:0021857 def: "The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021824 ! cerebral cortex tangential migration using cell-axon interactions is_a: GO:0021856 ! hypothalamic tangential migration using cell-axon interactions relationship: part_of GO:0021888 ! hypothalamus gonadotrophin-releasing hormone neuron development [Term] id: GO:0021829 name: oligodendrocyte cell migration from the subpallium to the cortex namespace: biological_process def: "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021826 ! substrate-independent telencephalic tangential migration [Term] id: GO:0021830 name: interneuron migration from the subpallium to the cortex namespace: biological_process def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021831 name: embryonic olfactory bulb interneuron precursor migration namespace: biological_process def: "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb relationship: part_of GO:0021891 ! olfactory bulb interneuron development [Term] id: GO:0021832 name: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions namespace: biological_process def: "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions [Term] id: GO:0021833 name: cell-matrix adhesion involved in tangential migration using cell-cell interactions namespace: biological_process def: "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex." [GO_REF:0000021, GOC:ascb_2009, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions [Term] id: GO:0021834 name: chemorepulsion involved in embryonic olfactory bulb interneuron migration namespace: biological_process def: "The creation and reception of signals that guide olfactory bulb interneurons down concentration gradients towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in embryonic olfactory bulb interneuron migration" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration [Term] id: GO:0021835 name: chemoattraction involved in embryonic olfactory bulb interneuron migration namespace: biological_process def: "The creation and reception of signals that result in the migration of interneurons up a concentration gradient towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis involved in embryonic olfactory bulb interneuron migration" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration [Term] id: GO:0021836 name: chemorepulsion involved in postnatal olfactory bulb interneuron migration namespace: biological_process def: "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in postnatal olfactory bulb interneuron migration" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration [Term] id: GO:0021837 name: motogenic signaling involved in postnatal olfactory bulb interneuron migration namespace: biological_process def: "The signaling that results in the stimulation of cell movement in the rostral migratory stream." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "motogenic signalling involved in postnatal olfactory bulb interneuron migration" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration [Term] id: GO:0021838 name: motogenic signaling involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "motogenic signalling involved in interneuron migration from the subpallium to the cortex" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex [Term] id: GO:0021839 name: interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex [Term] id: GO:0021840 name: directional guidance of interneurons involved in migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0030334 ! regulation of cell migration relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex [Term] id: GO:0021841 name: chemoattraction involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex [Term] id: GO:0021842 name: chemorepulsion involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex [Term] id: GO:0021843 name: substrate-independent telencephalic tangential interneuron migration namespace: biological_process def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021826 ! substrate-independent telencephalic tangential migration [Term] id: GO:0021844 name: interneuron sorting involved in substrate-independent cerebral cortex tangential migration namespace: biological_process def: "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0042330 ! taxis relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021845 name: neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration namespace: biological_process def: "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0030334 ! regulation of cell migration relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021846 name: cell proliferation in forebrain namespace: biological_process def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021847 name: ventricular zone neuroblast division namespace: biological_process def: "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neuroblast division in ventricular zone" EXACT [GOC:curators] is_a: GO:0021869 ! forebrain ventricular zone progenitor cell division is_a: GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021848 name: neuroblast division in subpallium namespace: biological_process def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447] is_a: GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0021849 name: neuroblast division in subventricular zone namespace: biological_process def: "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0021850 name: subpallium glioblast cell division namespace: biological_process def: "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "glioblast cell division in subpallium" EXACT [GOC:curators] synonym: "glioblast division in ventral telencephalon" EXACT [PMID:16226447] is_a: GO:0048860 ! glioblast division relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0021851 name: neuroblast division in dorsal lateral ganglionic eminence namespace: biological_process def: "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021848 ! neuroblast division in subpallium [Term] id: GO:0021852 name: pyramidal neuron migration namespace: biological_process def: "The migration of pyramidal a neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "projection neuron migration" RELATED [PMID:12626695] is_a: GO:0001764 ! neuron migration is_a: GO:0021801 ! cerebral cortex radial glia guided migration relationship: part_of GO:0021860 ! pyramidal neuron development [Term] id: GO:0021853 name: cerebral cortex GABAergic interneuron migration namespace: biological_process def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex relationship: part_of GO:0021894 ! cerebral cortex GABAergic interneuron development [Term] id: GO:0021854 name: hypothalamus development namespace: biological_process def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021855 name: hypothalamus cell migration namespace: biological_process def: "The directed movement of a cell into the hypothalamus region of the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016477 ! cell migration relationship: part_of GO:0021854 ! hypothalamus development [Term] id: GO:0021856 name: hypothalamic tangential migration using cell-axon interactions namespace: biological_process def: "The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021855 ! hypothalamus cell migration [Term] id: GO:0021858 name: GABAergic neuron differentiation in basal ganglia namespace: biological_process def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0021859 name: pyramidal neuron differentiation namespace: biological_process def: "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "projection neuron differentiation" BROAD [PMID:16226447] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0021860 name: pyramidal neuron development namespace: biological_process def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "projection neuron development" BROAD [PMID:16226447] is_a: GO:0021884 ! forebrain neuron development relationship: part_of GO:0021859 ! pyramidal neuron differentiation [Term] id: GO:0021861 name: forebrain radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "radial glial cell differentiation in forebrain" EXACT [GOC:curators] is_a: GO:0060019 ! radial glial cell differentiation relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021862 name: early neuron differentiation in forebrain namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021863 name: forebrain neuroblast differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447] synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447] synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447] is_a: GO:0014016 ! neuroblast differentiation relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021864 name: radial glial cell division in forebrain namespace: biological_process def: "The mitotic division of radial glial cells in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0051301 ! cell division relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0021865 name: symmetric radial glial cell division in forebrain namespace: biological_process def: "The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021864 ! radial glial cell division in forebrain [Term] id: GO:0021866 name: asymmetric radial glial cell division in forebrain namespace: biological_process def: "The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021864 ! radial glial cell division in forebrain [Term] id: GO:0021867 name: neuron-producing asymmetric radial glial cell division in forebrain namespace: biological_process def: "The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021866 ! asymmetric radial glial cell division in forebrain [Term] id: GO:0021868 name: ventricular zone cell-producing asymmetric radial glial cell division in forebrain namespace: biological_process def: "The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021866 ! asymmetric radial glial cell division in forebrain [Term] id: GO:0021869 name: forebrain ventricular zone progenitor cell division namespace: biological_process def: "The mitotic division of a basal progenitor giving rise to two neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0051301 ! cell division relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0021870 name: Cajal-Retzius cell differentiation namespace: biological_process def: "The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021895 ! cerebral cortex neuron differentiation [Term] id: GO:0021871 name: forebrain regionalization namespace: biological_process def: "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021872 name: forebrain generation of neurons namespace: biological_process def: "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "generation of neurons in forebrain" EXACT [GOC:curators] is_a: GO:0048699 ! generation of neurons relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021873 name: forebrain neuroblast division namespace: biological_process def: "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0055057 ! neuroblast division relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021874 name: Wnt receptor signaling pathway involved in forebrain neuroblast division namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signalling pathway in forebrain neuroblast division" EXACT [] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021875 name: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "fibroblast growth factor receptor signalling pathway in forebrain neuroblast division" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021876 name: Notch signaling pathway involved in forebrain neuroblast division namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Notch signalling pathway in forebrain neuroblast division" EXACT [] is_a: GO:0007219 ! Notch signaling pathway relationship: part_of GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021877 name: forebrain neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021878 name: forebrain astrocyte fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0060018 ! astrocyte fate commitment relationship: part_of GO:0021896 ! forebrain astrocyte differentiation [Term] id: GO:0021879 name: forebrain neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021880 name: Notch signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Notch signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0007219 ! Notch signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021881 name: Wnt receptor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021882 name: regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021883 name: cell cycle arrest of committed forebrain neuronal progenitor cell namespace: biological_process def: "The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0007050 ! cell cycle arrest relationship: part_of GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021884 name: forebrain neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021954 ! central nervous system neuron development relationship: part_of GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021885 name: forebrain cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016477 ! cell migration relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021886 name: hypothalamus gonadotrophin-releasing hormone neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021979 ! hypothalamus cell differentiation [Term] id: GO:0021887 name: hypothalamus gonadotrophin-releasing hormone neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation [Term] id: GO:0021888 name: hypothalamus gonadotrophin-releasing hormone neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021884 ! forebrain neuron development relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation [Term] id: GO:0021889 name: olfactory bulb interneuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021772 ! olfactory bulb development [Term] id: GO:0021890 name: olfactory bulb interneuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation [Term] id: GO:0021891 name: olfactory bulb interneuron development namespace: biological_process def: "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048666 ! neuron development relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation [Term] id: GO:0021892 name: cerebral cortex GABAergic interneuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021895 ! cerebral cortex neuron differentiation [Term] id: GO:0021893 name: cerebral cortex GABAergic interneuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation [Term] id: GO:0021894 name: cerebral cortex GABAergic interneuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021954 ! central nervous system neuron development relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation [Term] id: GO:0021895 name: cerebral cortex neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021896 name: forebrain astrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0048708 ! astrocyte differentiation relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021897 name: forebrain astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0014002 ! astrocyte development relationship: part_of GO:0021896 ! forebrain astrocyte differentiation [Term] id: GO:0021898 name: commitment of multipotent stem cells to neuronal lineage in forebrain namespace: biological_process def: "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021877 ! forebrain neuron fate commitment [Term] id: GO:0021899 name: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021900 name: ventricular zone cell fate commitment namespace: biological_process def: "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021863 ! forebrain neuroblast differentiation [Term] id: GO:0021901 name: early neuron fate commitment in forebrain namespace: biological_process def: "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021862 ! early neuron differentiation in forebrain [Term] id: GO:0021902 name: commitment of neuronal cell to specific neuron type in forebrain namespace: biological_process def: "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021877 ! forebrain neuron fate commitment [Term] id: GO:0021903 name: rostrocaudal neural tube patterning namespace: biological_process def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0021532 ! neural tube patterning [Term] id: GO:0021904 name: dorsal/ventral neural tube patterning namespace: biological_process def: "The process in which the neural tube is regionalized in the dorsoventral axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "dorsal-ventral neural tube patterning" EXACT [GOC:dph] synonym: "dorsoventral neural tube patterning" EXACT [GOC:mah] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0021532 ! neural tube patterning [Term] id: GO:0021905 name: forebrain-midbrain boundary formation namespace: biological_process def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0021906 name: hindbrain-spinal cord boundary formation namespace: biological_process def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0021907 name: fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021908 name: retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] is_a: GO:0048384 ! retinoic acid receptor signaling pathway relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021909 name: regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021910 name: smoothened signaling pathway involved in ventral spinal cord patterning namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway in ventral spinal cord patterning" EXACT [] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning [Term] id: GO:0021911 name: retinoic acid metabolic process in spinal cord anterior-posterior patterning namespace: biological_process def: "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "retinoic acid metabolism in spinal cord anterior-posterior patterning" EXACT [] is_a: GO:0042573 ! retinoic acid metabolic process relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021912 name: regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification [Term] id: GO:0021913 name: regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification [Term] id: GO:0021914 name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "down regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] synonym: "down-regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] synonym: "downregulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] synonym: "inhibition of smoothened signaling pathway in ventral spinal cord patterning" NARROW [] synonym: "negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of smoothened signalling pathway in ventral spinal cord patterning" EXACT [] is_a: GO:0045879 ! negative regulation of smoothened signaling pathway is_a: GO:0051960 ! regulation of nervous system development relationship: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning [Term] id: GO:0021915 name: neural tube development namespace: biological_process def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0021916 name: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors namespace: biological_process def: "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors" EXACT [] is_a: GO:0031129 ! inductive cell-cell signaling relationship: part_of GO:0021917 ! somatic motor neuron fate commitment [Term] id: GO:0021917 name: somatic motor neuron fate commitment namespace: biological_process def: "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021523 ! somatic motor neuron differentiation [Term] id: GO:0021918 name: regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021917 ! somatic motor neuron fate commitment [Term] id: GO:0021919 name: BMP signaling pathway involved in spinal cord dorsal/ventral patterning namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. synonym: "BMP signaling pathway in spinal cord dorsoventral patterning" EXACT [GOC:mah] synonym: "BMP signaling pathway involved in spinal cord dorsal-ventral patterning" EXACT [GOC:mah] synonym: "BMP signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT [] synonym: "bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning" EXACT [] synonym: "bone morphogenetic protein signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT [] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0021914 ! negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [Term] id: GO:0021920 name: regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021519 ! spinal cord association neuron specification [Term] id: GO:0021921 name: regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:2000177 ! regulation of neural precursor cell proliferation relationship: part_of GO:0021516 ! dorsal spinal cord development relationship: regulates GO:0010456 ! cell proliferation in dorsal spinal cord [Term] id: GO:0021922 name: Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0021921 ! regulation of cell proliferation in dorsal spinal cord [Term] id: GO:0021923 name: cell proliferation in hindbrain ventricular zone namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021534 ! cell proliferation in hindbrain [Term] id: GO:0021924 name: cell proliferation in external granule layer namespace: biological_process def: "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021534 ! cell proliferation in hindbrain [Term] id: GO:0021925 name: cerebellar Purkinje cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021926 name: Golgi cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021927 name: deep nuclear neuron precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021928 name: basket cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021929 name: stellate cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021930 name: cerebellar granule cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021924 ! cell proliferation in external granule layer [Term] id: GO:0021931 name: rostral hindbrain neuronal precursor cell proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021924 ! cell proliferation in external granule layer [Term] id: GO:0021932 name: hindbrain radial glia guided cell migration namespace: biological_process def: "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021535 ! cell migration in hindbrain [Term] id: GO:0021933 name: radial glia guided migration of cerebellar granule cell namespace: biological_process def: "The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021934 name: hindbrain tangential cell migration namespace: biological_process def: "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "hindbrain neurophilic migration" RELATED [PMID:15157725] is_a: GO:0021535 ! cell migration in hindbrain [Term] id: GO:0021935 name: cerebellar granule cell precursor tangential migration namespace: biological_process def: "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021934 ! hindbrain tangential cell migration [Term] id: GO:0021936 name: regulation of cerebellar granule cell precursor proliferation namespace: biological_process def: "The process that modulates the frequency, rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0051960 ! regulation of nervous system development is_a: GO:2000177 ! regulation of neural precursor cell proliferation relationship: regulates GO:0021930 ! cerebellar granule cell precursor proliferation [Term] id: GO:0021937 name: cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation namespace: biological_process def: "The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0021940 ! positive regulation of cerebellar granule cell precursor proliferation [Term] id: GO:0021938 name: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway in regulation of granule cell precursor cell proliferation" EXACT [] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0021937 ! cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [Term] id: GO:0021939 name: extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation namespace: biological_process def: "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation" EXACT [] is_a: GO:0035426 ! extracellular matrix-cell signaling relationship: part_of GO:0021941 ! negative regulation of cerebellar granule cell precursor proliferation [Term] id: GO:0021940 name: positive regulation of cerebellar granule cell precursor proliferation namespace: biological_process def: "The process that activates or increases the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "activation of granule cell precursor proliferation" NARROW [] synonym: "stimulation of granule cell precursor proliferation" NARROW [] synonym: "up regulation of granule cell precursor proliferation" EXACT [] synonym: "up-regulation of granule cell precursor proliferation" EXACT [] synonym: "upregulation of granule cell precursor proliferation" EXACT [] is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation relationship: positively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation [Term] id: GO:0021941 name: negative regulation of cerebellar granule cell precursor proliferation namespace: biological_process def: "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "down regulation of granule cell precursor proliferation" EXACT [] synonym: "down-regulation of granule cell precursor proliferation" EXACT [] synonym: "downregulation of granule cell precursor proliferation" EXACT [] synonym: "inhibition of granule cell precursor proliferation" NARROW [] is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation relationship: negatively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation [Term] id: GO:0021942 name: radial glia guided migration of Purkinje cell namespace: biological_process def: "The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021943 name: formation of radial glial scaffolds namespace: biological_process def: "The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "Bergmann fiber biosynthesis" RELATED [PMID:15157725] synonym: "Bergmann fiber formation" RELATED [PMID:15157725] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021944 name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration namespace: biological_process def: "The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021945 name: positive regulation of cerebellar granule cell migration by calcium namespace: biological_process def: "The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "calcium-mediated activation of granule cell migration" NARROW [] synonym: "calcium-mediated positive regulation of granule cell migration" EXACT [GOC:dph, GOC:tb] synonym: "calcium-mediated stimulation of granule cell migration" NARROW [] synonym: "calcium-mediated up regulation of granule cell migration" EXACT [] synonym: "calcium-mediated up-regulation of granule cell migration" EXACT [] synonym: "calcium-mediated upregulation of granule cell migration" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0030335 ! positive regulation of cell migration relationship: part_of GO:0021933 ! radial glia guided migration of cerebellar granule cell [Term] id: GO:0021946 name: deep nuclear neuron cell migration namespace: biological_process def: "The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021535 ! cell migration in hindbrain [Term] id: GO:0021947 name: outward migration of deep nuclear neurons namespace: biological_process def: "The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0001764 ! neuron migration relationship: part_of GO:0021946 ! deep nuclear neuron cell migration [Term] id: GO:0021948 name: inward migration of deep nuclear neurons namespace: biological_process def: "The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0001764 ! neuron migration relationship: part_of GO:0021946 ! deep nuclear neuron cell migration [Term] id: GO:0021949 name: brainstem precerebellar neuron precursor migration namespace: biological_process def: "The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021934 ! hindbrain tangential cell migration [Term] id: GO:0021950 name: chemorepulsion involved in precerebellar neuron migration namespace: biological_process def: "The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration [Term] id: GO:0021951 name: chemoattraction involved in precerebellar neuron migration namespace: biological_process def: "The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration [Term] id: GO:0021952 name: central nervous system projection neuron axonogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "central nervous system axon tract development" NARROW [GOC:dph] is_a: GO:0021955 ! central nervous system neuron axonogenesis [Term] id: GO:0021953 name: central nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021954 name: central nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048666 ! neuron development relationship: part_of GO:0021953 ! central nervous system neuron differentiation [Term] id: GO:0021955 name: central nervous system neuron axonogenesis namespace: biological_process def: "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0007409 ! axonogenesis relationship: part_of GO:0021954 ! central nervous system neuron development [Term] id: GO:0021956 name: central nervous system interneuron axonogenesis namespace: biological_process def: "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021955 ! central nervous system neuron axonogenesis [Term] id: GO:0021957 name: corticospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal tract axonogenesis" EXACT [GOC:dph, PMID:9878731] synonym: "CST axonogenesis" EXACT [GOC:dph, PMID:9878731] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021958 name: gracilis tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698] comment: This term was added by GO_REF:0000021. synonym: "tract of Goll morphogenesis" EXACT [PMID:12867698] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021959 name: cuneatus tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698] comment: This term was added by GO_REF:0000021. synonym: "tract of Burdach morphogenesis" EXACT [PMID:12867698] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021960 name: anterior commissure morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021961 name: posterior commissure morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021962 name: vestibulospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021963 name: spinothalamic tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "dorsolateral tract of Lissauer morphogenesis" EXACT [] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021964 name: rubrospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021965 name: spinal cord ventral commissure morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021966 name: corticospinal neuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021957 ! corticospinal tract morphogenesis [Term] id: GO:0021967 name: corticospinal neuron axon guidance through the cerebral cortex namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the cerebral cortex" NARROW [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021968 name: corticospinal neuron axon guidance through the internal capsule namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the internal capsule" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021969 name: corticospinal neuron axon guidance through the cerebral peduncle namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the cerebral peduncle" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021970 name: corticospinal neuron axon guidance through the basilar pons namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the basilar pons" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021971 name: corticospinal neuron axon guidance through the medullary pyramid namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the medullary pyramid" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021972 name: corticospinal neuron axon guidance through spinal cord namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through spinal cord" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021973 name: corticospinal neuron axon decussation namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. is_a: GO:0016199 ! axon midline choice point recognition relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021974 name: trigeminothalamic tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021975 name: pons reticulospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021976 name: medulla reticulospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021977 name: tectospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021978 name: telencephalon regionalization namespace: biological_process def: "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0021537 ! telencephalon development relationship: part_of GO:0021871 ! forebrain regionalization [Term] id: GO:0021979 name: hypothalamus cell differentiation namespace: biological_process def: "The differentiation of cells that will contribute to the structure and function of the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021854 ! hypothalamus development [Term] id: GO:0021980 name: subpallium cell migration namespace: biological_process def: "The orderly movement of cells from one site to another in the subpallium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022029 ! telencephalon cell migration relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0021981 name: subpallium radially oriented migration namespace: biological_process def: "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021980 ! subpallium cell migration [Term] id: GO:0021982 name: pineal gland development namespace: biological_process def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "epiphysis development" EXACT [GOC:dph] is_a: GO:0048732 ! gland development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0021983 name: pituitary gland development namespace: biological_process def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "hypophysis development" RELATED [GOC:dph] is_a: GO:0048732 ! gland development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0021984 name: adenohypophysis development namespace: biological_process def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "adenophysis development" EXACT [] synonym: "anterior pituitary development" EXACT [] synonym: "anterior pituitary gland development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021983 ! pituitary gland development [Term] id: GO:0021985 name: neurohypophysis development namespace: biological_process def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neurophysis development" EXACT [] synonym: "posterior pituitary development" EXACT [] synonym: "posterior pituitary gland development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021983 ! pituitary gland development [Term] id: GO:0021986 name: habenula development namespace: biological_process def: "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:9780721601465] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021538 ! epithalamus development [Term] id: GO:0021987 name: cerebral cortex development namespace: biological_process def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neocortex development" RELATED [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021543 ! pallium development [Term] id: GO:0021988 name: olfactory lobe development namespace: biological_process def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021989 name: olfactory cortex development namespace: biological_process def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021988 ! olfactory lobe development [Term] id: GO:0021990 name: neural plate formation namespace: biological_process def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878932437, ISBN:0878932585, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0021991 name: neural plate thickening namespace: biological_process def: "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0021992 name: cell proliferation involved in neural plate elongation namespace: biological_process def: "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0014022 ! neural plate elongation [Term] id: GO:0021993 name: initiation of neural tube closure namespace: biological_process def: "The process in which closure points are established at multiple points and along the neural rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0021994 name: progression of neural tube closure namespace: biological_process def: "The process in which the neural folds are fused extending from the initial closure points." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0021995 name: neuropore closure namespace: biological_process def: "The process of joining together the neural folds at either end of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0021996 name: lamina terminalis formation namespace: biological_process def: "The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0021506 ! anterior neuropore closure [Term] id: GO:0021997 name: neural plate axis specification namespace: biological_process def: "The pattern specification process in which the axes of the nervous system are established." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neural plate axis determination" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification relationship: part_of GO:0001840 ! neural plate development relationship: part_of GO:0060896 ! neural plate pattern specification [Term] id: GO:0021998 name: neural plate mediolateral regionalization namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neural plate mediolateral pattern formation" RELATED [GOC:dph] is_a: GO:0060897 ! neural plate regionalization [Term] id: GO:0021999 name: neural plate anterior/posterior regionalization namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph] is_a: GO:0060897 ! neural plate regionalization [Term] id: GO:0022000 name: forebrain induction by the anterior neural ridge namespace: biological_process def: "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0031128 ! developmental induction relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0022001 name: negative regulation of anterior neural cell fate commitment of the neural plate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb] comment: This term was added by GO_REF:0000021. synonym: "caudalization of neural plate" EXACT [] synonym: "down regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "down-regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "downregulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "inhibition of anterior neural cell fate of the neural plate" NARROW [] synonym: "negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] synonym: "posteriorization" BROAD [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0051961 ! negative regulation of nervous system development relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0022002 name: negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway namespace: biological_process def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] synonym: "Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] synonym: "Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] is_a: GO:0016055 ! Wnt receptor signaling pathway is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate [Term] id: GO:0022003 name: negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb] comment: This term was added by GO_REF:0000021. synonym: "fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] synonym: "fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] synonym: "fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate [Term] id: GO:0022004 name: midbrain-hindbrain boundary maturation during brain development namespace: biological_process def: "A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. is_a: GO:0032502 ! developmental process relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation [Term] id: GO:0022005 name: midbrain-hindbrain boundary maturation during neural plate development namespace: biological_process def: "A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "midbrain-hindbrain boundary maturation involved in neural plate development" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0001840 ! neural plate development relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation [Term] id: GO:0022006 name: zona limitans intrathalamica formation namespace: biological_process def: "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11425897, PMID:16452095] comment: This term was added by GO_REF:0000021. synonym: "zli biosynthesis" EXACT [] synonym: "zli formation" EXACT [] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0022007 name: convergent extension involved in neural plate elongation namespace: biological_process def: "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060029 ! convergent extension involved in organogenesis relationship: part_of GO:0014022 ! neural plate elongation [Term] id: GO:0022008 name: neurogenesis namespace: biological_process def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "nervous system cell generation" EXACT systematic_synonym [] synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph] xref: Wikipedia:Neurogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0022009 name: central nervous system vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0001570 ! vasculogenesis relationship: part_of GO:0014045 ! establishment of endothelial blood-brain barrier [Term] id: GO:0022010 name: central nervous system myelination namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "myelination in central nervous system" EXACT [] is_a: GO:0032291 ! axon ensheathment in central nervous system is_a: GO:0042552 ! myelination relationship: part_of GO:0014003 ! oligodendrocyte development [Term] id: GO:0022011 name: myelination in peripheral nervous system namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "peripheral nervous system myelination" EXACT [] is_a: GO:0032292 ! peripheral nervous system axon ensheathment is_a: GO:0042552 ! myelination relationship: part_of GO:0014044 ! Schwann cell development [Term] id: GO:0022012 name: subpallium cell proliferation in forebrain namespace: biological_process def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021846 ! cell proliferation in forebrain relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0022013 name: pallium cell proliferation in forebrain namespace: biological_process def: "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021846 ! cell proliferation in forebrain relationship: part_of GO:0021543 ! pallium development [Term] id: GO:0022014 name: radial glial cell division in subpallium namespace: biological_process def: "The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021864 ! radial glial cell division in forebrain relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022015 name: radial glial cell division in pallium namespace: biological_process def: "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0051301 ! cell division relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain [Term] id: GO:0022016 name: pallium glioblast division namespace: biological_process def: "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "glioblast cell division in pallium" EXACT [GOC:curators] is_a: GO:0048860 ! glioblast division relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain [Term] id: GO:0022017 name: neuroblast division in pallium namespace: biological_process def: "The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain [Term] id: GO:0022018 name: lateral ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022019 name: dorsal lateral ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain relationship: part_of GO:0022018 ! lateral ganglionic eminence cell proliferation [Term] id: GO:0022020 name: medial ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022021 name: caudal ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022022 name: septal cell proliferation namespace: biological_process def: "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "septum cell proliferation" EXACT [] is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022023 name: radial glial cell fate commitment in forebrain namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021861 ! forebrain radial glial cell differentiation [Term] id: GO:0022024 name: BMP signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "BMP signalling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0022025 name: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0048861 ! leukemia inhibitory factor signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0022026 name: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "epidermal growth factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0022027 name: interkinetic nuclear migration namespace: biological_process def: "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0051647 ! nucleus localization relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0022028 name: tangential migration from the subventricular zone to the olfactory bulb namespace: biological_process def: "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rostral migratory stream migration" EXACT [] is_a: GO:0022029 ! telencephalon cell migration relationship: part_of GO:0021772 ! olfactory bulb development [Term] id: GO:0022029 name: telencephalon cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021885 ! forebrain cell migration relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0022030 name: telencephalon glial cell migration namespace: biological_process def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0008347 ! glial cell migration is_a: GO:0022029 ! telencephalon cell migration [Term] id: GO:0022031 name: telencephalon astrocyte cell migration namespace: biological_process def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022030 ! telencephalon glial cell migration is_a: GO:0043615 ! astrocyte cell migration [Term] id: GO:0022032 name: telencephalon oligodendrocyte cell migration namespace: biological_process def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0022033 name: telencephalon microglial cell migration namespace: biological_process def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0022034 name: rhombomere cell proliferation namespace: biological_process def: "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0022035 name: rhombomere cell migration namespace: biological_process def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15629700] comment: This term was added by GO_REF:0000021. is_a: GO:0021535 ! cell migration in hindbrain relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0022036 name: rhombomere cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0022037 name: metencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0022038 name: corpus callosum development namespace: biological_process def: "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0022400 name: regulation of rhodopsin mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling." [GOC:mah] synonym: "regulation of rhodopsin mediated signalling" EXACT [] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway relationship: regulates GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0022401 name: negative adaptation of signaling pathway namespace: biological_process def: "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:isa_complete] synonym: "negative adaptation of signal transduction pathway" EXACT [] synonym: "negative adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0023058 ! adaptation of signaling pathway [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0009987 ! cellular process relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0022403 name: cell cycle phase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events." [GOC:dph, GOC:isa_complete, GOC:tb] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0022404 name: molting cycle process namespace: biological_process def: "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete] is_a: GO:0042303 ! molting cycle [Term] id: GO:0022405 name: hair cycle process namespace: biological_process def: "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0042633 ! hair cycle [Term] id: GO:0022406 name: membrane docking namespace: biological_process def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0022407 name: regulation of cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete] is_a: GO:0030155 ! regulation of cell adhesion relationship: regulates GO:0016337 ! cell-cell adhesion [Term] id: GO:0022408 name: negative regulation of cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "down regulation of cell-cell adhesion" EXACT [] synonym: "down-regulation of cell-cell adhesion" EXACT [] synonym: "downregulation of cell-cell adhesion" EXACT [] synonym: "inhibition of cell-cell adhesion" NARROW [] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion relationship: negatively_regulates GO:0016337 ! cell-cell adhesion [Term] id: GO:0022409 name: positive regulation of cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "activation of cell-cell adhesion" NARROW [] synonym: "stimulation of cell-cell adhesion" NARROW [] synonym: "up regulation of cell-cell adhesion" EXACT [] synonym: "up-regulation of cell-cell adhesion" EXACT [] synonym: "upregulation of cell-cell adhesion" EXACT [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0045785 ! positive regulation of cell adhesion relationship: positively_regulates GO:0016337 ! cell-cell adhesion [Term] id: GO:0022410 name: circadian sleep/wake cycle process namespace: biological_process def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete] is_a: GO:0048512 ! circadian behavior relationship: part_of GO:0042745 ! circadian sleep/wake cycle [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] subset: goslim_pir subset: gosubset_prok synonym: "cell structure disassembly" EXACT [] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] synonym: "reproductive cellular process in multicellular organism" EXACT [GOC:curators] is_a: GO:0048610 ! cellular process involved in reproduction [Term] id: GO:0022413 name: reproductive process in single-celled organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0032505 ! reproduction of a single-celled organism [Term] id: GO:0022414 name: reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] subset: gosubset_prok is_a: GO:0008150 ! biological_process relationship: part_of GO:0000003 ! reproduction [Term] id: GO:0022415 name: viral reproductive process namespace: biological_process def: "A reproductive process involved in viral reproduction. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:isa_complete] synonym: "viral life cycle process" EXACT [] is_a: GO:0022414 ! reproductive process relationship: part_of GO:0016032 ! viral reproduction [Term] id: GO:0022416 name: bristle development namespace: biological_process def: "The process whose specific outcome is the progression of the bristle over time, from its formation to the mature structure. A bristle is an insect sensory organ." [GOC:isa_complete] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0022417 name: protein maturation by protein folding namespace: biological_process def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete] is_a: GO:0006457 ! protein folding is_a: GO:0051604 ! protein maturation [Term] id: GO:0022600 name: digestive system process namespace: biological_process def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio] is_a: GO:0003008 ! system process relationship: part_of GO:0007586 ! digestion [Term] id: GO:0022601 name: menstrual cycle phase namespace: biological_process def: "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048731 ! system development [Term] id: GO:0022602 name: ovulation cycle process namespace: biological_process def: "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete] synonym: "estrous cycle process" RELATED [] synonym: "menstrual cycle process" RELATED [] is_a: GO:0048511 ! rhythmic process relationship: part_of GO:0042698 ! ovulation cycle [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] subset: gosubset_prok synonym: "regulation of morphogenesis" EXACT [] is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0022604 name: regulation of cell morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] subset: gosubset_prok synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0000902 ! cell morphogenesis [Term] id: GO:0022605 name: oogenesis stage namespace: biological_process def: "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu] synonym: "oogenesis process" EXACT [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0022606 name: establishment of proximal/distal cell polarity namespace: biological_process def: "The specification and formation of the polarity of a cell along its proximal/distal axis." [GOC:isa_complete] is_a: GO:0061162 ! establishment of monopolar cell polarity [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "cell structure assembly" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0044085 ! cellular component biogenesis [Term] id: GO:0022608 name: multicellular organism adhesion namespace: biological_process def: "The attachment of a multicellular organism to a substrate or other organism." [GOC:isa_complete] is_a: GO:0022610 ! biological adhesion is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0022609 name: multicellular organism adhesion to substrate namespace: biological_process def: "The attachment of a multicellular organism to a surface or material." [GOC:isa_complete] is_a: GO:0022608 ! multicellular organism adhesion [Term] id: GO:0022610 name: biological adhesion namespace: biological_process def: "The attachment of a cell or organism to a substrate or other organism." [GOC:isa_complete] subset: goslim_pir subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0022611 name: dormancy process namespace: biological_process def: "The process in which a dormant state is induced, maintained or broken. Dormancy is characterized by a suspension of physiological activity." [GOC:isa_complete] is_a: GO:0032502 ! developmental process [Term] id: GO:0022612 name: gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048732 ! gland development [Term] id: GO:0022613 name: ribonucleoprotein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] subset: gosubset_prok synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah] synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah] is_a: GO:0071843 ! cellular component biogenesis at cellular level [Term] id: GO:0022614 name: membrane to membrane docking namespace: biological_process def: "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere." [GOC:isa_complete] synonym: "membrane-membrane docking" EXACT [] is_a: GO:0022406 ! membrane docking [Term] id: GO:0022615 name: protein to membrane docking namespace: biological_process def: "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete] synonym: "protein-membrane docking" EXACT [] is_a: GO:0022406 ! membrane docking [Term] id: GO:0022616 name: DNA strand elongation namespace: biological_process def: "The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:isa_complete] is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0022617 name: extracellular matrix disassembly namespace: biological_process def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid] is_a: GO:0030198 ! extracellular matrix organization is_a: GO:0071845 ! cellular component disassembly at cellular level [Term] id: GO:0022618 name: ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_generic subset: gosubset_prok synonym: "protein-RNA complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0034622 ! cellular macromolecular complex assembly is_a: GO:0071826 ! ribonucleoprotein complex subunit organization relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis [Term] id: GO:0022619 name: generative cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte." [GOC:isa_complete] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0055046 ! microgametogenesis [Term] id: GO:0022620 name: vegetative cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube." [GOC:isa_complete] synonym: "tube cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0055046 ! microgametogenesis [Term] id: GO:0022621 name: shoot system development namespace: biological_process def: "The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure." [GOC:isa_complete] is_a: GO:0048731 ! system development [Term] id: GO:0022622 name: root system development namespace: biological_process def: "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure." [GOC:isa_complete] is_a: GO:0048731 ! system development [Term] id: GO:0022623 name: proteasome-activating nucleotidase complex namespace: cellular_component def: "A multisubunit complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:mtg_sensu] synonym: "PAN" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0022624 name: proteasome accessory complex namespace: cellular_component def: "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0000502 ! proteasome complex [Term] id: GO:0022625 name: cytosolic large ribosomal subunit namespace: cellular_component alt_id: GO:0005842 alt_id: GO:0009282 alt_id: GO:0030498 alt_id: GO:0030872 def: "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "50S ribosomal subunit" NARROW [] synonym: "60S ribosomal subunit" NARROW [] synonym: "eukaryotic ribosomal LSU" NARROW [] synonym: "prokaryotic large ribosomal subunit" NARROW [] is_a: GO:0015934 ! large ribosomal subunit relationship: part_of GO:0022626 ! cytosolic ribosome [Term] id: GO:0022626 name: cytosolic ribosome namespace: cellular_component alt_id: GO:0005830 alt_id: GO:0009281 alt_id: GO:0030871 def: "A ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "70S ribosome" NARROW [] synonym: "80S ribosome" NARROW [] is_a: GO:0005840 ! ribosome is_a: GO:0044445 ! cytosolic part [Term] id: GO:0022627 name: cytosolic small ribosomal subunit namespace: cellular_component alt_id: GO:0005843 alt_id: GO:0009283 alt_id: GO:0030499 alt_id: GO:0030873 def: "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "30S ribosomal subunit" NARROW [] synonym: "40S ribosomal subunit" NARROW [] synonym: "eukaryotic ribosomal SSU" NARROW [] synonym: "prokaryotic small ribosomal subunit" NARROW [] is_a: GO:0015935 ! small ribosomal subunit relationship: part_of GO:0022626 ! cytosolic ribosome [Term] id: GO:0022628 name: chloroplast large ribosomal subunit namespace: cellular_component def: "The large subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] synonym: "chloroplast ribosomal large subunit complex" EXACT [] synonym: "chloroplast ribosomal LSU complex" EXACT [] is_a: GO:0000311 ! plastid large ribosomal subunit is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0043253 ! chloroplast ribosome [Term] id: GO:0022629 name: chloroplast small ribosomal subunit namespace: cellular_component def: "The small subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] synonym: "chloroplast ribosomal small subunit complex" EXACT [] synonym: "chloroplast ribosomal SSU complex" EXACT [] is_a: GO:0000312 ! plastid small ribosomal subunit is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0043253 ! chloroplast ribosome [Term] id: GO:0022803 name: passive transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: Reactome:258204 "passive transmembrane transporter activity" is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022804 name: active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "active carrier activity" EXACT [] synonym: "carrier activity" EXACT [] synonym: "permease activity" EXACT [] synonym: "pump activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022809 name: mobile ion carrier activity namespace: molecular_function def: "This is a type of carrier produced by bacteria. It enable passive transport by shielding the ion that is being transported from the lipid membrane. It carries an ion across the membrane by enclosing the ion and travelling across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionophore" BROAD [] is_a: GO:0022803 ! passive transmembrane transporter activity [Term] id: GO:0022810 name: membrane potential driven uniporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] synonym: "porter" BROAD [] is_a: GO:0022814 ! facilitated diffusion [Term] id: GO:0022814 name: facilitated diffusion namespace: molecular_function def: "Catalysis of the transfer of a single solute from one side of the membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] synonym: "porters" BROAD [] synonym: "uniporter activity z" EXACT [] xref: Wikipedia:Facilitated_diffusion is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0022815 name: large uncharged polar molecule transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term. is_obsolete: true replaced_by: GO:0022891 [Term] id: GO:0022818 name: sodium ion uniporter activity namespace: molecular_function def: "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0022810 ! membrane potential driven uniporter activity [Term] id: GO:0022819 name: potassium ion uniporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0022810 ! membrane potential driven uniporter activity [Term] id: GO:0022820 name: potassium ion symporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015293 ! symporter activity [Term] id: GO:0022821 name: potassium ion antiporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015297 ! antiporter activity [Term] id: GO:0022824 name: transmitter-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015276 ! ligand-gated ion channel activity is_a: GO:0022835 ! transmitter-gated channel activity [Term] id: GO:0022825 name: copper-exporting ATPase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was a placeholder during work on transporter terms, and was not defined. is_obsolete: true replaced_by: GO:0043682 [Term] id: GO:0022828 name: phosphorylation-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022829 name: wide pore channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "gap junction activity" NARROW [] synonym: "non-gated, wide pore channel activity" EXACT [] is_a: GO:0015267 ! channel activity [Term] id: GO:0022831 name: narrow pore, gated channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729] synonym: "ion channels" EXACT [] xref: Wikipedia:Ion_channels is_a: GO:0022842 ! narrow pore channel activity [Term] id: GO:0022832 name: voltage-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022833 name: mechanically gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022834 name: ligand-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022835 name: transmitter-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular substance gated channel activity" EXACT [] synonym: "neurotransmitter-gated channel activity" EXACT [] is_a: GO:0022834 ! ligand-gated channel activity [Term] id: GO:0022836 name: gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport] is_a: GO:0015267 ! channel activity [Term] id: GO:0022838 name: substrate-specific channel activity namespace: molecular_function def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport] is_a: GO:0015267 ! channel activity is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0022839 name: ion gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022840 name: leak channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022842 ! narrow pore channel activity [Term] id: GO:0022841 name: potassium ion leak channel activity namespace: molecular_function def: "Catalysis of the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0022840 ! leak channel activity [Term] id: GO:0022842 name: narrow pore channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015267 ! channel activity [Term] id: GO:0022843 name: voltage-gated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005244 ! voltage-gated ion channel activity is_a: GO:0005261 ! cation channel activity [Term] id: GO:0022848 name: acetylcholine-gated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022824 ! transmitter-gated ion channel activity [Term] id: GO:0022849 name: glutamate-gated calcium ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022824 ! transmitter-gated ion channel activity [Term] id: GO:0022850 name: serotonin-gated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022824 ! transmitter-gated ion channel activity [Term] id: GO:0022851 name: GABA-gated chloride ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022824 ! transmitter-gated ion channel activity [Term] id: GO:0022852 name: glycine-gated chloride ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022824 ! transmitter-gated ion channel activity [Term] id: GO:0022853 name: active ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0022854 name: active large uncharged polar molecule transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term. is_obsolete: true replaced_by: GO:0022804 [Term] id: GO:0022855 name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "glucose PTS transporter activity" EXACT [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022856 name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sorbitol PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015576 ! sorbitol transmembrane transporter activity [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function alt_id: GO:0005386 alt_id: GO:0015646 def: "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: Reactome:258158 "transmembrane transporter activity" is_a: GO:0005215 ! transporter activity [Term] id: GO:0022858 name: alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0022859 name: dephosphorylation-gated channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022865 name: transmembrane electron transfer carrier namespace: molecular_function def: "Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5] xref: TC:5 is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022866 name: transmembrane 1-electron transfer carrier namespace: molecular_function def: "Enables transfer of one electron across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.B] synonym: "transmembrane one-electron transfer carrier" EXACT [GOC:mah] is_a: GO:0022865 ! transmembrane electron transfer carrier [Term] id: GO:0022867 name: transmembrane 2-electron transfer carrier namespace: molecular_function def: "Enables transfer of two electrons across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.A] synonym: "transmembrane two-electron transfer carrier" EXACT [GOC:mah] is_a: GO:0022865 ! transmembrane electron transfer carrier [Term] id: GO:0022869 name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "lactose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015155 ! lactose transmembrane transporter activity [Term] id: GO:0022870 name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "mannose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015578 ! mannose transmembrane transporter activity [Term] id: GO:0022871 name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sorbose PTS transporter activity" EXACT [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0019194 ! sorbose transmembrane transporter activity [Term] id: GO:0022872 name: protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "mannitol PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015575 ! mannitol transmembrane transporter activity [Term] id: GO:0022873 name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "maltose PTS transporter activity" EXACT [] is_a: GO:0005363 ! maltose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022874 name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "cellobiose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0019191 ! cellobiose transmembrane transporter activity [Term] id: GO:0022875 name: protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "galactitol PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015577 ! galactitol transmembrane transporter activity [Term] id: GO:0022876 name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "galactosamine PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0019196 ! galactosamine transmembrane transporter activity [Term] id: GO:0022877 name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "fructose PTS transporter activity" EXACT [] is_a: GO:0005353 ! fructose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022878 name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sucrose PTS transporter activity" EXACT [] is_a: GO:0008515 ! sucrose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022879 name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "trehalose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015574 ! trehalose transmembrane transporter activity [Term] id: GO:0022880 name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylglucosamine PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015572 ! N-acetylglucosamine transmembrane transporter activity is_a: GO:0015574 ! trehalose transmembrane transporter activity [Term] id: GO:0022881 name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylgalactosamine PTS transporter activity" EXACT [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015571 ! N-acetylgalactosamine transmembrane transporter activity [Term] id: GO:0022882 name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "beta-glucoside PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity [Term] id: GO:0022883 name: zinc efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "zinc efflux permease activity" EXACT [] is_a: GO:0005385 ! zinc ion transmembrane transporter activity is_a: GO:0046583 ! cation efflux transmembrane transporter activity [Term] id: GO:0022884 name: macromolecule transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a macromolecule from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0022885 name: bacteriocin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a bacteriocin from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: GO:0022886 name: channel-forming ionophore activity namespace: molecular_function def: "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionophore activity" BROAD [] is_a: GO:0015267 ! channel activity [Term] id: GO:0022889 name: serine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0022890 name: inorganic cation transmembrane transporter activity namespace: molecular_function alt_id: GO:0015082 def: "Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah] is_a: GO:0008324 ! cation transmembrane transporter activity [Term] id: GO:0022891 name: substrate-specific transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0022857 ! transmembrane transporter activity is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0022892 name: substrate-specific transporter activity namespace: molecular_function def: "Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:mtg_transport] subset: gosubset_prok is_a: GO:0005215 ! transporter activity [Term] id: GO:0022893 name: low-affinity tryptophan transmembrane transporter activity namespace: molecular_function alt_id: GO:0015510 def: "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:mtg_transport, ISBN:0815340729] synonym: "low-affinity tryptophan permease activity" RELATED [] is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity [Term] id: GO:0022894 name: Intermediate conductance calcium-activated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] synonym: "IK calcium-activated potassium channel activity " EXACT [] synonym: "IK KCa channels" EXACT [] synonym: "intermdiate conductance KCa channels " EXACT [] is_a: GO:0015269 ! calcium-activated potassium channel activity [Term] id: GO:0022897 name: proton-dependent peptide secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport] subset: gosubset_prok synonym: "hydrogen/oligopeptide symporter" RELATED [] is_a: GO:0015197 ! peptide transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0022898 name: regulation of transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] subset: gosubset_prok is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0034762 ! regulation of transmembrane transport [Term] id: GO:0022900 name: electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] subset: gosubset_prok xref: Wikipedia:Electron_transport_chain is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0022904 name: respiratory electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094] subset: gosubset_prok synonym: "6-phosphofructokinase reduction" RELATED [] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "dihydrolipoamide reduction" RELATED [] synonym: "dihydrolipoylprotein reduction" RELATED [] synonym: "dihydropteridine reduction" RELATED [] synonym: "electron transfer" EXACT [] synonym: "other pathways of electron transport" RELATED [] synonym: "oxidized glutathione reduction" RELATED [] synonym: "protein-disulfide reduction" RELATED [] xref: Reactome:1253325 "Respiratory electron transport" xref: Reactome:1253326 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1280263 "Respiratory electron transport" xref: Reactome:1280264 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1299122 "Respiratory electron transport" xref: Reactome:1299123 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1326841 "Respiratory electron transport" xref: Reactome:1326842 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1352934 "Respiratory electron transport" xref: Reactome:1352935 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1373141 "Respiratory electron transport" xref: Reactome:1373142 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1393157 "Respiratory electron transport" xref: Reactome:1393158 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1417642 "Respiratory electron transport" xref: Reactome:1417643 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1450743 "Respiratory electron transport" xref: Reactome:1450744 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1471184 "Respiratory electron transport" xref: Reactome:1471185 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1483176 "Respiratory electron transport" xref: Reactome:1483177 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1496892 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1496893 "Respiratory electron transport" xref: Reactome:1514285 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1514286 "Respiratory electron transport" xref: Reactome:1521131 "Respiratory electron transport" xref: Reactome:1521132 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1526891 "Respiratory electron transport" xref: Reactome:1526892 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1532620 "Respiratory electron transport" xref: Reactome:1532621 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1538041 "Respiratory electron transport" xref: Reactome:1538042 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:1539323 "Respiratory electron transport" xref: Reactome:1539324 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:163200 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." xref: Reactome:611105 "Respiratory electron transport" xref: Wikipedia:Electron_transfer is_a: GO:0022900 ! electron transport chain relationship: part_of GO:0045333 ! cellular respiration [Term] id: GO:0023002 name: nuclear migration to embryo sac poles namespace: biological_process def: "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X] synonym: "nuclear migration to female gametophyte poles" EXACT [] synonym: "nuclear migration to megagametophyte poles" EXACT [] synonym: "nucleus migration to embryo sac poles" EXACT [] synonym: "nucleus migration to female gametophyte poles" EXACT [] synonym: "nucleus migration to megagametophyte poles" EXACT [] is_a: GO:0009562 ! embryo sac nuclear migration [Term] id: GO:0023003 name: nuclear migration to the embryo sac center namespace: biological_process def: "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X] synonym: "nuclear migration to the embryo sac centre" EXACT [] synonym: "nuclear migration to the female gametophyte center" EXACT [] synonym: "nuclear migration to the female gametophyte centre" EXACT [] synonym: "nuclear migration to the megagametophyte center" EXACT [] synonym: "nuclear migration to the megagametophyte centre" EXACT [] synonym: "nucleus migration to the female gametophyte center" EXACT [] synonym: "nucleus migration to the female gametophyte centre" EXACT [] is_a: GO:0009562 ! embryo sac nuclear migration [Term] id: GO:0023004 name: activation of dopamine receptor signaling pathway namespace: biological_process def: "OBSOLETE. Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "activation of dopamine receptor signalling pathway" EXACT [GOC:mah] synonym: "initiation of dopamine receptor signaling pathway" RELATED [] synonym: "stimulation of dopamine receptor signaling pathway" EXACT [] is_obsolete: true consider: GO:0060161 [Term] id: GO:0023005 name: signal initiation by neurotransmitter namespace: biological_process def: "OBSOLETE. The process in which a neurotransmitter signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0007165 consider: GO:0030594 [Term] id: GO:0023006 name: signal initiation by amino acid namespace: biological_process def: "OBSOLETE. The process in which an amino acid signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0007215 consider: GO:0008066 consider: GO:0071230 [Term] id: GO:0023007 name: ligand binding to T cell receptor namespace: biological_process def: "OBSOLETE. Binding of a diffusible ligand to a T cell receptor as part of a signaling process." [GOC:jid, GOC:mtg_signal] comment: This term was made obsolete because it is describing a binding molecular function. is_obsolete: true consider: GO:0042101 consider: GO:0042608 consider: GO:0050852 [Term] id: GO:0023009 name: initiation of T cell receptor signaling namespace: biological_process def: "OBSOLETE. The process in which a signal causes activation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "initiation of T cell receptor signalling" EXACT [GOC:mah] is_obsolete: true consider: GO:0004872 consider: GO:0042101 consider: GO:0048018 consider: GO:0050852 [Term] id: GO:0023010 name: regulation of initiation of T cell receptor signaling namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "regulation of initiation of T cell receptor signalling" EXACT [GOC:mah] is_obsolete: true consider: GO:0050856 [Term] id: GO:0023011 name: positive regulation of initiation of T cell receptor signaling namespace: biological_process def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "positive regulation of initiation of T cell receptor signalling" EXACT [GOC:mah] is_obsolete: true consider: GO:0050862 [Term] id: GO:0023012 name: initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor namespace: biological_process def: "OBSOLETE. The process in which binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because it is describing a binding molecular function. synonym: "initiation of T cell receptor signalling by binding of a MHC complex to T cell receptor" EXACT [GOC:mah] is_obsolete: true consider: GO:0042101 consider: GO:0050852 [Term] id: GO:0023014 name: signal transduction via phosphorylation event namespace: biological_process def: "The process in which a signal is conveyed via the transfer of one or more phosphate groups." [GOC:mtg_signal] synonym: "signal transmission via phosphorylation event" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction [Term] id: GO:0023015 name: signal transduction via a cis-phosphorylation event namespace: biological_process def: "The process in which a signal is conveyed via the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule." [GOC:bf, GOC:mtg_signal] synonym: "signal transmission via a cis-phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via auto-phosphorylation" EXACT [] is_a: GO:0023014 ! signal transduction via phosphorylation event [Term] id: GO:0023016 name: signal transduction via a trans-phosphorylation event namespace: biological_process def: "The process in which a signal is conveyed via the transfer of one or more phosphate groups by a kinase to a residue in a different molecule." [GOC:bf, GOC:mtg_signal] synonym: "signal transmission via a trans-phosphorylation event" RELATED [GOC:bf] is_a: GO:0023014 ! signal transduction via phosphorylation event [Term] id: GO:0023017 name: signal transmission via diffusible molecule namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via a diffusible molecule." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signaling via diffusible mediator" EXACT [] is_obsolete: true consider: GO:0007267 [Term] id: GO:0023018 name: T cell activation of signal transmission via diffusible molecule namespace: biological_process def: "OBSOLETE. The process in which signal transmission via a diffusible molecule is initiated by a T cell." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true [Term] id: GO:0023019 name: signal transduction involved in regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0010468 ! regulation of gene expression [Term] id: GO:0023020 name: regulation of gene expression as a consequence of T cell signal transmission namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a T cell signal is released and/or conveyed from one location to another." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0023019 [Term] id: GO:0023021 name: termination of signal transduction namespace: biological_process def: "The signaling process in which signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal] comment: Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn. is_a: GO:0009968 ! negative regulation of signal transduction [Term] id: GO:0023022 name: termination of T cell signal transduction namespace: biological_process def: "The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal] is_a: GO:0023021 ! termination of signal transduction is_a: GO:0050860 ! negative regulation of T cell receptor signaling pathway relationship: part_of GO:0050852 ! T cell receptor signaling pathway [Term] id: GO:0023023 name: MHC protein complex binding namespace: molecular_function def: "Interacting selectively with the major histocompatibility complex." [GOC:mtg_signal] is_a: GO:0003823 ! antigen binding [Term] id: GO:0023024 name: MHC class I protein complex binding namespace: molecular_function def: "Interacting selectively with the class I major histocompatibility complex." [GOC:mtg_signal] is_a: GO:0023023 ! MHC protein complex binding [Term] id: GO:0023025 name: MHC class Ib protein complex binding namespace: molecular_function def: "Interacting selectively with the class Ib major histocompatibility complex." [GOC:mtg_signal] is_a: GO:0023023 ! MHC protein complex binding [Term] id: GO:0023026 name: MHC class II protein complex binding namespace: molecular_function def: "Interacting selectively with the class II major histocompatibility complex." [GOC:mtg_signal] is_a: GO:0023023 ! MHC protein complex binding [Term] id: GO:0023027 name: MHC class I protein binding, via antigen binding groove namespace: molecular_function def: "Interacting selectively with major histocompatibility complex class I molecules via the antigen binding groove." [GOC:mtg_signal] is_a: GO:0042288 ! MHC class I protein binding relationship: part_of GO:0023024 ! MHC class I protein complex binding [Term] id: GO:0023028 name: MHC class I protein binding, via lateral surface namespace: molecular_function def: "Interacting selectively with major histocompatibility complex class I molecules via the lateral surface." [GOC:mtg_signal] is_a: GO:0042288 ! MHC class I protein binding [Term] id: GO:0023029 name: MHC class Ib protein binding namespace: molecular_function def: "Interacting selectively with major histocompatibility complex class Ib molecules." [GOC:mtg_signal] is_a: GO:0042287 ! MHC protein binding [Term] id: GO:0023030 name: MHC class Ib protein binding, via antigen binding groove namespace: molecular_function def: "Interacting selectively with major histocompatibility complex class Ib molecules via the antigen binding groove." [GOC:mtg_signal] is_a: GO:0023029 ! MHC class Ib protein binding relationship: part_of GO:0023025 ! MHC class Ib protein complex binding [Term] id: GO:0023031 name: MHC class Ib protein binding, via lateral surface namespace: molecular_function def: "Interacting selectively with major histocompatibility complex class Ib molecules via the lateral surface." [GOC:mtg_signal] is_a: GO:0023029 ! MHC class Ib protein binding [Term] id: GO:0023035 name: CD40 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to the receptor CD40." [GOC:mtg_signal] synonym: "CD40 signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0023036 name: initiation of signal transduction namespace: biological_process def: "OBSOLETE. The process in which a signal causes activation of a receptor, for example, via a conformation change." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. Note that this term was intended for the annotation of both ligands and receptors. synonym: "signal reception" RELATED [] is_obsolete: true consider: GO:0004872 consider: GO:0007165 consider: GO:0048018 [Term] id: GO:0023037 name: signal initiation by light namespace: biological_process def: "OBSOLETE. The process in which a light signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0009785 consider: GO:0009881 consider: GO:0010017 consider: GO:0010018 consider: GO:0010161 [Term] id: GO:0023038 name: signal initiation by diffusible mediator namespace: biological_process def: "OBSOLETE. The process in which a diffusible signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0004872 consider: GO:0007165 consider: GO:0038001 consider: GO:0048018 [Term] id: GO:0023039 name: signal initiation by physical damage namespace: biological_process def: "OBSOLETE. The process in which a physical damage signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0004872 consider: GO:0033554 [Term] id: GO:0023040 name: signaling via ionic flux namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via ionic flux." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signalling via ionic flux" EXACT [GOC:mah] is_obsolete: true consider: GO:0023052 [Term] id: GO:0023041 name: neuronal signal transduction namespace: biological_process def: "The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular." [GOC:mtg_signal] is_a: GO:0007165 ! signal transduction [Term] id: GO:0023042 name: signaling via protein/peptide mediator namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signalling via protein/peptide mediator" EXACT [GOC:mah] is_obsolete: true consider: GO:0023052 [Term] id: GO:0023043 name: signaling via lipid mediator namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signalling via lipid mediator" EXACT [GOC:mah] is_obsolete: true consider: GO:0014065 consider: GO:0023052 [Term] id: GO:0023044 name: signaling via chemical mediator namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signalling via chemical mediator" EXACT [GOC:mah] is_obsolete: true consider: GO:0023052 [Term] id: GO:0023045 name: signal transduction via conformational transition namespace: biological_process def: "The process whereby a signal is passed on within a cell by triggering a conformational change in the molecule that is receiving the signal." [GOC:bf, GOC:mtg_signal] synonym: "signal transmission via conformational transition" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction [Term] id: GO:0023047 name: signal initiation by chemical mediator namespace: biological_process def: "OBSOLETE. The process in which a chemical signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0004872 consider: GO:0007165 consider: GO:0070887 [Term] id: GO:0023048 name: signal initiation by lipid mediator namespace: biological_process def: "OBSOLETE. The process in which a lipid signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0007165 consider: GO:0045125 [Term] id: GO:0023049 name: signal initiation by protein/peptide mediator namespace: biological_process def: "OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0004872 consider: GO:0007165 consider: GO:0048018 [Term] id: GO:0023050 name: consequence of signal transmission namespace: biological_process def: "OBSOLETE. The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state." [GOC:mtg_signal] comment: This term was made obsolete because the term is no longer needed. synonym: "signal termination" EXACT [] is_obsolete: true [Term] id: GO:0023051 name: regulation of signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "regulation of signaling process" RELATED [GOC:bf] synonym: "regulation of signalling process" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0023052 ! signaling [Term] id: GO:0023052 name: signaling namespace: biological_process alt_id: GO:0023046 def: "The entirety of a process in which information is transmitted. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. subset: goslim_pombe synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling process" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0023053 name: signal initiation by mechanical effect namespace: biological_process def: "OBSOLETE. The process in which a mechanical signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0004872 consider: GO:0007165 consider: GO:0071260 [Term] id: GO:0023054 name: signal initiation by stretch effect namespace: biological_process def: "OBSOLETE. The process in which a stretch signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0004872 consider: GO:0007165 [Term] id: GO:0023055 name: signal initiation by peptide hormone namespace: biological_process def: "OBSOLETE. The process in which a signal is initiated by a peptide hormone." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0004879 consider: GO:0005179 consider: GO:0009755 [Term] id: GO:0023056 name: positive regulation of signaling namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "positive regulation of signaling process" RELATED [GOC:bf] synonym: "positive regulation of signalling process" EXACT [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0023052 ! signaling [Term] id: GO:0023057 name: negative regulation of signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "negative regulation of signaling process" RELATED [GOC:bf] synonym: "negative regulation of signalling process" RELATED [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0023052 ! signaling [Term] id: GO:0023058 name: adaptation of signaling pathway namespace: biological_process def: "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal] synonym: "adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction [Term] id: GO:0023059 name: positive adaptation of signaling pathway namespace: biological_process def: "The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal] synonym: "positive adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0023058 ! adaptation of signaling pathway [Term] id: GO:0023060 name: signal transmission namespace: biological_process def: "OBSOLETE. The process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0023052 [Term] id: GO:0023061 name: signal release namespace: biological_process def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal] is_a: GO:0009987 ! cellular process relationship: part_of GO:0003001 ! generation of a signal involved in cell-cell signaling [Term] id: GO:0023062 name: signal transmission via transcytosis namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [GOC:mtg_signal, ISBN:0716731363] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0023052 consider: GO:0045056 [Term] id: GO:0023065 name: signal transmission via blood namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via blood." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0010232 consider: GO:0023052 [Term] id: GO:0023066 name: signal transmission via vascular system namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the vascular system." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0010232 consider: GO:0023052 [Term] id: GO:0023067 name: signal transmission via lymphatic system namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the lymphatic system." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0023052 [Term] id: GO:0023068 name: signal transmission via phloem namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the phloem." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0010233 consider: GO:0023052 [Term] id: GO:0023069 name: signal transmission via xylem namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the xylem." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0010232 consider: GO:0023052 [Term] id: GO:0023070 name: signal transmission via air namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the air." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0035636 [Term] id: GO:0030001 name: metal ion transport namespace: biological_process def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "heavy metal ion transport" NARROW [] is_a: GO:0006812 ! cation transport [Term] id: GO:0030002 name: cellular anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of anions at the level of a cell." [GOC:ceb, GOC:mah] is_a: GO:0006873 ! cellular ion homeostasis is_a: GO:0055081 ! anion homeostasis [Term] id: GO:0030003 name: cellular cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cations at the level of a cell." [GOC:ceb, GOC:mah] subset: gosubset_prok is_a: GO:0006873 ! cellular ion homeostasis is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0030004 name: cellular monovalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell." [GOC:ai, GOC:mah] subset: gosubset_prok is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0030005 name: cellular di-, tri-valent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent or trivalent cations at the level of a cell." [GOC:ceb, GOC:mah] subset: gosubset_prok is_obsolete: true consider: GO:0072503 consider: GO:0072504 [Term] id: GO:0030006 name: heavy cellular metal ion homeostasis namespace: biological_process def: "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0006875 [Term] id: GO:0030007 name: cellular potassium ion homeostasis namespace: biological_process alt_id: GO:0017079 def: "Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell." [GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis is_a: GO:0055075 ! potassium ion homeostasis [Term] id: GO:0030008 name: TRAPP complex namespace: cellular_component def: "A large complex present on the cis-Golgi that acts prior to SNARE complex assembly to mediate vesicle docking and fusion. Ras guanyl-nucleotide exchange factor activity has been demonstrated for this complex in S. cerevisiae." [GOC:vw, PMID:17287728, PMID:9564032] synonym: "transport protein particle" EXACT [] synonym: "TRAPP1" NARROW [GOC:vw] synonym: "TRAPP2" NARROW [GOC:vw] xref: Wikipedia:TRAPP_complex is_a: GO:0043234 ! protein complex is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0005801 ! cis-Golgi network [Term] id: GO:0030009 name: complement factor H activity namespace: molecular_function def: "OBSOLETE. A cofactor for the serine protease complement factor I." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0006956 [Term] id: GO:0030010 name: establishment of cell polarity namespace: biological_process alt_id: GO:0000283 alt_id: GO:0030468 def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] synonym: "bud site selection/establishment of cell polarity" NARROW [] synonym: "cell polarization" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030011 name: maintenance of cell polarity namespace: biological_process alt_id: GO:0030013 alt_id: GO:0030469 def: "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030014 name: CCR4-NOT complex namespace: cellular_component def: "A large multimeric transcription factor complex that can regulate transcription positively or negatively; consists of a core complex plus additional proteins; may interact with other proteins to control initiation of transcription. In Saccharomyces the core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p; Caf4p, Caf16p, and several less well characterized proteins." [PMID:11113136] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0030015 name: CCR4-NOT core complex namespace: cellular_component def: "The core of the CCR4-NOT transcription factor complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p." [PMID:11113136] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0030014 ! CCR4-NOT complex [Term] id: GO:0030016 name: myofibril namespace: cellular_component def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] synonym: "striated muscle fiber" EXACT [] synonym: "striated muscle fibre" EXACT [] xref: Wikipedia:Myofibril is_a: GO:0043292 ! contractile fiber [Term] id: GO:0030017 name: sarcomere namespace: cellular_component def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] xref: Wikipedia:Sarcomere is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030016 ! myofibril [Term] id: GO:0030018 name: Z disc namespace: cellular_component def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] synonym: "Z band" EXACT [] synonym: "Z disk" EXACT [] synonym: "Z line" EXACT [] is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0031674 ! I band [Term] id: GO:0030019 name: tryptase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [EC:3.4.21.59] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "lung tryptase activity" NARROW [EC:3.4.21.59] synonym: "mast cell neutral proteinase activity" EXACT [EC:3.4.21.59] synonym: "mast cell protease II activity" NARROW [EC:3.4.21.59] synonym: "mast cell proteinase II" RELATED [EC:3.4.21.59] synonym: "mast cell serine proteinase II" RELATED [EC:3.4.21.59] synonym: "mast cell serine proteinase tryptase activity" EXACT [EC:3.4.21.59] synonym: "mast cell tryptase activity" NARROW [EC:3.4.21.59] synonym: "pituitary tryptase activity" NARROW [EC:3.4.21.59] synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59] synonym: "skin tryptase activity" NARROW [EC:3.4.21.59] synonym: "tryptase M" RELATED [EC:3.4.21.59] xref: EC:3.4.21.59 xref: MetaCyc:3.4.21.59-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030020 name: extracellular matrix structural constituent conferring tensile strength namespace: molecular_function def: "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030021 name: extracellular matrix structural constituent conferring compression resistance namespace: molecular_function def: "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030022 name: adhesive extracellular matrix constituent namespace: molecular_function def: "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix." [GOC:mah, ISBN:0815316194] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true replaced_by: GO:0005578 replaced_by: GO:0030674 replaced_by: GO:0050839 replaced_by: GO:0050840 [Term] id: GO:0030023 name: extracellular matrix constituent conferring elasticity namespace: molecular_function def: "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194] synonym: "elastin" RELATED [] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030026 name: cellular manganese ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell." [GOC:mah] subset: gosubset_prok synonym: "manganese homeostasis" BROAD [] is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055071 ! manganese ion homeostasis [Term] id: GO:0030027 name: lamellipodium namespace: cellular_component def: "A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments." [ISBN:0815316194] xref: Wikipedia:Lamellipodia is_a: GO:0042995 ! cell projection relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0030029 name: actin filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] synonym: "microfilament-based process" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] subset: gosubset_prok synonym: "cell projection organisation" EXACT [GOC:curators] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0030031 name: cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] subset: gosubset_prok synonym: "cell projection biogenesis" RELATED [GOC:mah] synonym: "formation of a cell surface projection" EXACT [] is_a: GO:0030030 ! cell projection organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0030032 name: lamellipodium assembly namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194] synonym: "lamellipodium biogenesis" RELATED [GOC:mah] synonym: "lamellipodium biosynthesis" EXACT [] synonym: "lamellipodium formation" EXACT [] is_a: GO:0030031 ! cell projection assembly [Term] id: GO:0030033 name: microvillus assembly namespace: biological_process def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194] synonym: "microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0030031 ! cell projection assembly is_a: GO:0032528 ! microvillus organization [Term] id: GO:0030034 name: microvillar actin bundle assembly namespace: biological_process def: "Assembly of the parallel bundle of actin filaments at the core of a microvillus." [GOC:mah] is_a: GO:0051017 ! actin filament bundle assembly relationship: part_of GO:0030033 ! microvillus assembly [Term] id: GO:0030035 name: microspike assembly namespace: biological_process def: "Formation of a microspike, a thin, stiff projection extended from the surface of a migrating cell." [GOC:mah, ISBN:0815316194] synonym: "microspike biogenesis" RELATED [GOC:mah] synonym: "microspike biosynthesis" EXACT [] synonym: "microspike formation" EXACT [] is_a: GO:0030031 ! cell projection assembly [Term] id: GO:0030036 name: actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] synonym: "actin cytoskeleton organisation" EXACT [GOC:curators] synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "actin modulating activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0030037 name: actin filament reorganization involved in cell cycle namespace: biological_process def: "The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah] synonym: "actin filament reorganization during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0007015 ! actin filament organization is_a: GO:0022402 ! cell cycle process is_a: GO:0031532 ! actin cytoskeleton reorganization [Term] id: GO:0030038 name: contractile actin filament bundle assembly namespace: biological_process def: "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:mah, ISBN:0815316194] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0030039 name: DNA unwinding factor namespace: molecular_function alt_id: GO:0017152 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. is_obsolete: true replaced_by: GO:0006268 [Term] id: GO:0030041 name: actin filament polymerization namespace: biological_process def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] synonym: "actin polymerization" EXACT [] synonym: "actin polymerizing activity" RELATED [] is_a: GO:0008154 ! actin polymerization or depolymerization is_a: GO:0051258 ! protein polymerization [Term] id: GO:0030042 name: actin filament depolymerization namespace: biological_process def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] synonym: "actin depolymerization" EXACT [] synonym: "actin depolymerizing activity" RELATED [] is_a: GO:0008154 ! actin polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization [Term] id: GO:0030043 name: actin filament fragmentation namespace: biological_process def: "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194] is_a: GO:0030042 ! actin filament depolymerization [Term] id: GO:0030046 name: parallel actin filament bundle assembly namespace: biological_process def: "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0030047 name: actin modification namespace: biological_process alt_id: GO:0007013 def: "Covalent modification of an actin molecule." [GOC:mah] is_a: GO:0006464 ! protein modification process is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0030048 name: actin filament-based movement namespace: biological_process def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:mah] is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0030049 name: muscle filament sliding namespace: biological_process def: "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated." [GOC:mah, GOC:mtg_muscle, ISBN:0815316194] xref: Reactome:1253684 "Striated Muscle Contraction" xref: Reactome:1280616 "Striated Muscle Contraction" xref: Reactome:1299447 "Striated Muscle Contraction" xref: Reactome:1327202 "Striated Muscle Contraction" xref: Reactome:1353296 "Striated Muscle Contraction" xref: Reactome:1373472 "Striated Muscle Contraction" xref: Reactome:1393493 "Striated Muscle Contraction" xref: Reactome:1417994 "Striated Muscle Contraction" xref: Reactome:1451081 "Striated Muscle Contraction" xref: Reactome:390522 "Striated Muscle Contraction" is_a: GO:0033275 ! actin-myosin filament sliding relationship: part_of GO:0006936 ! muscle contraction [Term] id: GO:0030050 name: vesicle transport along actin filament namespace: biological_process def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0051648 ! vesicle localization [Term] id: GO:0030051 name: FK506-sensitive peptidyl-prolyl cis-trans isomerase namespace: molecular_function def: "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0))." [EC:5.2.1.8, ISBN:0198596732] comment: This term was made obsolete because it represents a gene product and not a function. synonym: "FK506 binding protein" RELATED [] synonym: "FKBP" RELATED [] is_obsolete: true replaced_by: GO:0003755 replaced_by: GO:0005528 [Term] id: GO:0030052 name: parvulin namespace: molecular_function def: "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it describes a gene product. is_obsolete: true replaced_by: GO:0003755 [Term] id: GO:0030053 name: immunophilin namespace: molecular_function def: "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003755 consider: GO:0004872 [Term] id: GO:0030054 name: cell junction namespace: cellular_component def: "A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Cell_junction is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0030055 name: cell-substrate junction namespace: cellular_component def: "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:hb, GOC:mah] synonym: "cell-matrix junction" EXACT [] is_a: GO:0030054 ! cell junction relationship: part_of GO:0016323 ! basolateral plasma membrane [Term] id: GO:0030056 name: hemidesmosome namespace: cellular_component def: "A cell-substrate junction that forms a point of contact between the basal surface of epithelial cells and the basal lamina. Morphologically resembles desmosomes; attached to intermediate filaments." [ISBN:0815316208] synonym: "hemi-adherens junction" RELATED [http://www.wormatlas.org/glossaries/hglossary.htm#hemiadherensjunction] xref: Wikipedia:Hemidesmosome is_a: GO:0030055 ! cell-substrate junction relationship: part_of GO:0009925 ! basal plasma membrane [Term] id: GO:0030057 name: desmosome namespace: cellular_component def: "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] synonym: "macula adherens" EXACT [] synonym: "spot desmosome" EXACT [] xref: Wikipedia:Desmosome is_a: GO:0005911 ! cell-cell junction is_a: GO:0070161 ! anchoring junction [Term] id: GO:0030058 name: amine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor." [EC:1.4.99.3] subset: gosubset_prok synonym: "amine: (acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] synonym: "MADH activity" EXACT [EC:1.4.99.3] synonym: "methylamine dehydrogenase activity" EXACT [EC:1.4.99.3] synonym: "primary-amine dehydrogenase activity" BROAD [EC:1.4.99.3] synonym: "primary-amine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] synonym: "primary-amine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] xref: EC:1.4.99.3 xref: MetaCyc:AMINE-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0058 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0030059 name: aralkylamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor." [EC:1.4.99.4] synonym: "aralkylamine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.4] synonym: "aralkylamine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.4] synonym: "aromatic amine dehydrogenase activity" EXACT [EC:1.4.99.4] synonym: "dehydrogenase, arylamine" EXACT [EC:1.4.99.4] synonym: "tyramine dehydrogenase activity" EXACT [EC:1.4.99.4] xref: EC:1.4.99.4 xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0030060 name: L-malate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37] subset: gosubset_prok synonym: "(S)-malate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] synonym: "L-malate-NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] synonym: "malate (NAD) dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "malic acid dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "MDH" RELATED [EC:1.1.1.37] synonym: "NAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-dependent malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-L-malate dehydrogenase activity" EXACT [] synonym: "NAD-linked malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-specific malate dehydrogenase activity" EXACT [EC:1.1.1.37] xref: EC:1.1.1.37 xref: MetaCyc:MALATE-DEH-RXN xref: Reactome:19541 "L-malate dehydrogenase activity" is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030061 name: mitochondrial crista namespace: cellular_component def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "mitochondrial cristae" EXACT [] xref: NIF_Subcellular:sao333328131 is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0030062 name: mitochondrial tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] synonym: "TCA cycle enzyme complex" BROAD [] is_a: GO:0044429 ! mitochondrial part is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0030063 name: murein sacculus namespace: cellular_component def: "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891] comment: This term was made obsolete because it was defined inaccurately. synonym: "peptidoglycan layer" EXACT [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0030064 name: cell wall inner membrane namespace: cellular_component def: "OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria." [ISBN:0135712254] comment: This term was made obsolete because it was defined inaccurately. is_obsolete: true consider: GO:0009276 [Term] id: GO:0030066 name: cytochrome b6 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome b-563" RELATED [] is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0030067 name: respiratory chain cytochrome b6 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0030068 name: lytic viral life cycle namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. is_obsolete: true consider: GO:0019058 consider: GO:0019077 [Term] id: GO:0030069 name: lysogeny namespace: biological_process def: "The incorporation of a bacteriophage genome into the genome of its bacterial host organism." [ISBN:0781702534] xref: Wikipedia:Lysogenic_cycle is_a: GO:0022415 ! viral reproductive process [Term] id: GO:0030070 name: insulin processing namespace: biological_process def: "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0016486 ! peptide hormone processing [Term] id: GO:0030071 name: regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah] is_a: GO:0007088 ! regulation of mitosis relationship: regulates GO:0007091 ! mitotic metaphase/anaphase transition [Term] id: GO:0030072 name: peptide hormone secretion namespace: biological_process def: "The regulated release of a peptide hormone from a cell or organ." [GOC:mah] is_a: GO:0002790 ! peptide secretion is_a: GO:0046879 ! hormone secretion [Term] id: GO:0030073 name: insulin secretion namespace: biological_process def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030074 name: thylakoid (sensu Proteobacteria) namespace: cellular_component def: "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah] comment: This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria. is_obsolete: true consider: GO:0042716 [Term] id: GO:0030075 name: plasma membrane-derived thylakoid namespace: cellular_component def: "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0009579 ! thylakoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0030076 name: light-harvesting complex namespace: cellular_component def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr] subset: goslim_pir subset: gosubset_prok synonym: "antenna complex" RELATED [] xref: Wikipedia:Light-harvesting_complex is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030077 name: plasma membrane light-harvesting complex namespace: cellular_component def: "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0030076 ! light-harvesting complex is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0030078 name: light-harvesting complex, core complex namespace: cellular_component def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr] subset: gosubset_prok is_a: GO:0030077 ! plasma membrane light-harvesting complex [Term] id: GO:0030079 name: light-harvesting complex, peripheral complex namespace: cellular_component def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr] subset: gosubset_prok is_a: GO:0030077 ! plasma membrane light-harvesting complex [Term] id: GO:0030080 name: B875 antenna complex namespace: cellular_component def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd] subset: gosubset_prok synonym: "LH1 complex" EXACT [] synonym: "light harvesting complex I" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030078 ! light-harvesting complex, core complex [Term] id: GO:0030081 name: B800-820 antenna complex namespace: cellular_component def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] subset: gosubset_prok synonym: "LH3 complex" EXACT [] synonym: "light harvesting complex III" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex [Term] id: GO:0030082 name: B800-850 antenna complex namespace: cellular_component def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] subset: gosubset_prok synonym: "LH2 complex" EXACT [] synonym: "light harvesting complex II" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex [Term] id: GO:0030083 name: PSI associated light-harvesting complex I, LHCIa subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475] is_a: GO:0009518 ! PSI associated light-harvesting complex I [Term] id: GO:0030084 name: PSI associated light-harvesting complex I, LHCIb subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475] is_a: GO:0009518 ! PSI associated light-harvesting complex I [Term] id: GO:0030085 name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009656 ! PSII associated light-harvesting complex II, peripheral complex [Term] id: GO:0030086 name: PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. is_obsolete: true replaced_by: GO:0009655 [Term] id: GO:0030087 name: PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. is_obsolete: true replaced_by: GO:0009655 [Term] id: GO:0030088 name: PSII associated light-harvesting complex II, core complex, LHCIId subcomplex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. is_obsolete: true replaced_by: GO:0009655 [Term] id: GO:0030089 name: phycobilisome namespace: cellular_component def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [GOC:jl, http://en.wikipedia.org/wiki/Phycobilisome, PMID:11734882] subset: gosubset_prok xref: Wikipedia:Phycobilisome is_a: GO:0030076 ! light-harvesting complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0030091 name: protein repair namespace: biological_process def: "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] subset: gosubset_prok is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0030092 name: regulation of flagellum assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] synonym: "regulation of flagella assembly" RELATED [GOC:mah] synonym: "regulation of flagella biogenesis" RELATED [] synonym: "regulation of flagellum biogenesis" RELATED [GOC:mah] is_a: GO:0060491 ! regulation of cell projection assembly relationship: regulates GO:0009296 ! flagellum assembly [Term] id: GO:0030093 name: chloroplast photosystem I namespace: cellular_component def: "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009522 ! photosystem I is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009535 ! chloroplast thylakoid membrane [Term] id: GO:0030094 name: plasma membrane-derived photosystem I namespace: cellular_component def: "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species." [GOC:jid, GOC:mtg_sensu] subset: gosubset_prok synonym: "plasma membrane photosystem I" EXACT [] is_a: GO:0009522 ! photosystem I is_a: GO:0044422 ! organelle part is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid [Term] id: GO:0030095 name: chloroplast photosystem II namespace: cellular_component def: "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009523 ! photosystem II is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009535 ! chloroplast thylakoid membrane [Term] id: GO:0030096 name: plasma membrane-derived thylakoid photosystem II namespace: cellular_component def: "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu] subset: gosubset_prok synonym: "plasma membrane photosystem II" EXACT [] is_a: GO:0009523 ! photosystem II is_a: GO:0044422 ! organelle part is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid [Term] id: GO:0030097 name: hemopoiesis namespace: biological_process def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "blood cell biosynthesis" EXACT [] synonym: "blood cell formation" EXACT [] synonym: "haemopoiesis" EXACT [] synonym: "hematopoiesis" EXACT [] xref: Wikipedia:Haematopoiesis is_a: GO:0048534 ! hemopoietic or lymphoid organ development [Term] id: GO:0030098 name: lymphocyte differentiation namespace: biological_process alt_id: GO:0046650 def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "lymphocyte cell differentiation" EXACT [] synonym: "lymphocyte development" RELATED [GOC:add] synonym: "lymphocytic blood cell differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0030099 name: myeloid cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0030100 name: regulation of endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0006897 ! endocytosis [Term] id: GO:0030101 name: natural killer cell activation namespace: biological_process def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140] synonym: "NK cell activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0030103 name: vasopressin secretion namespace: biological_process def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030104 name: water homeostasis namespace: biological_process alt_id: GO:0018987 def: "Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb] synonym: "osmoregulation" RELATED [] synonym: "regulation of osmotic pressure" EXACT [] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0030105 name: anaphylaxis namespace: biological_process def: "OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a an abnormal process that is harmful to the organism. is_obsolete: true consider: GO:0006955 [Term] id: GO:0030106 name: MHC class I receptor activity namespace: molecular_function def: "OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells)." [ISBN:081533642X, ISBN:0879694971] comment: This term was made obsolete because the definition is ambiguous and contains incorrect information. To update annotations of gene products that act as receptors for MHC class I protein complexes, use the molecular function term 'MHC class I receptor activity ; GO:0032393'; to update annotations of gene products which are components of MHC class I protein complexes, use the cellular component term 'MHC class I protein complex ; GO:0042612'. synonym: "class I major histocompatibility complex antigen" RELATED [] synonym: "major histocompatibility complex class I receptor" EXACT [] is_obsolete: true consider: GO:0032393 consider: GO:0042612 [Term] id: GO:0030107 name: HLA-A specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032396 ! inhibitory MHC class I receptor activity [Term] id: GO:0030108 name: HLA-A specific activating MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032397 ! activating MHC class I receptor activity [Term] id: GO:0030109 name: HLA-B specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032396 ! inhibitory MHC class I receptor activity [Term] id: GO:0030110 name: HLA-C specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032396 ! inhibitory MHC class I receptor activity [Term] id: GO:0030111 name: regulation of Wnt receptor signaling pathway namespace: biological_process alt_id: GO:0008590 def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of frizzled signaling pathway" EXACT [] synonym: "regulation of frizzled signalling pathway" EXACT [] synonym: "regulation of Wnt receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0016055 ! Wnt receptor signaling pathway [Term] id: GO:0030112 name: glycocalyx namespace: cellular_component def: "A viscous, carbohydrate rich layer at the outermost periphery of a cell." [GOC:mlg, ISBN:0815316208] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Glycocalyx is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0030114 name: slime layer namespace: cellular_component def: "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, http://www.wikipedia.org/Slime_layer] xref: Wikipedia:Slime_layer is_a: GO:0030112 ! glycocalyx [Term] id: GO:0030115 name: S-layer namespace: cellular_component def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:S-layer is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0030116 name: glial cell line-derived neurotrophic factor receptor binding namespace: molecular_function def: "A growth factor that binds to glial cell line-derived neurotrophic factor receptors." [PMID:11476867] synonym: "glial cell line-derived neurotrophic factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0030117 name: membrane coat namespace: cellular_component def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0048475 ! coated membrane [Term] id: GO:0030118 name: clathrin coat namespace: cellular_component alt_id: GO:0016190 def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549] synonym: "clathrin cage" EXACT [] xref: NIF_Subcellular:sao879919129 xref: Wikipedia:Clathrin is_a: GO:0030117 ! membrane coat [Term] id: GO:0030119 name: AP-type membrane coat adaptor complex namespace: cellular_component def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838] subset: goslim_pir synonym: "clathrin adaptor" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0030117 ! membrane coat [Term] id: GO:0030120 name: vesicle coat namespace: cellular_component def: "A membrane coat found on a coated vesicle." [GOC:mah] xref: NIF_Subcellular:sao1177708494 is_a: GO:0030117 ! membrane coat is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030662 ! coated vesicle membrane [Term] id: GO:0030121 name: AP-1 adaptor complex namespace: cellular_component def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499] synonym: "HA1" EXACT [] synonym: "HA1 clathrin adaptor" EXACT [] is_a: GO:0030131 ! clathrin adaptor complex is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030130 ! clathrin coat of trans-Golgi network vesicle [Term] id: GO:0030122 name: AP-2 adaptor complex namespace: cellular_component def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499] synonym: "HA2" EXACT [] synonym: "HA2 clathrin adaptor" EXACT [] is_a: GO:0030131 ! clathrin adaptor complex is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0030128 ! clathrin coat of endocytic vesicle relationship: part_of GO:0030132 ! clathrin coat of coated pit [Term] id: GO:0030123 name: AP-3 adaptor complex namespace: cellular_component def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499] is_a: GO:0030119 ! AP-type membrane coat adaptor complex [Term] id: GO:0030124 name: AP-4 adaptor complex namespace: cellular_component def: "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976] is_a: GO:0030119 ! AP-type membrane coat adaptor complex [Term] id: GO:0030125 name: clathrin vesicle coat namespace: cellular_component def: "A clathrin coat found on a vesicle." [GOC:mah] is_a: GO:0030118 ! clathrin coat is_a: GO:0030120 ! vesicle coat relationship: part_of GO:0030665 ! clathrin coated vesicle membrane [Term] id: GO:0030126 name: COPI vesicle coat namespace: cellular_component alt_id: GO:0017167 def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] synonym: "coatomer" EXACT [] is_a: GO:0030120 ! vesicle coat is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0030663 ! COPI coated vesicle membrane [Term] id: GO:0030127 name: COPII vesicle coat namespace: cellular_component def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894] is_a: GO:0030120 ! vesicle coat relationship: part_of GO:0012507 ! ER to Golgi transport vesicle membrane [Term] id: GO:0030128 name: clathrin coat of endocytic vesicle namespace: cellular_component def: "A clathrin coat found on an endocytic vesicle." [GOC:mah] synonym: "clathrin coat of endocytotic vesicle" EXACT [] is_a: GO:0030125 ! clathrin vesicle coat relationship: part_of GO:0030669 ! clathrin-coated endocytic vesicle membrane [Term] id: GO:0030129 name: clathrin coat of synaptic vesicle namespace: cellular_component def: "A clathrin coat found on a synaptic vesicle." [GOC:mah] is_a: GO:0030125 ! clathrin vesicle coat is_a: GO:0044456 ! synapse part relationship: part_of GO:0030672 ! synaptic vesicle membrane [Term] id: GO:0030130 name: clathrin coat of trans-Golgi network vesicle namespace: cellular_component def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] synonym: "clathrin coat of TGN vesicle" EXACT [] is_a: GO:0030125 ! clathrin vesicle coat is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane [Term] id: GO:0030131 name: clathrin adaptor complex namespace: cellular_component def: "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] is_a: GO:0030119 ! AP-type membrane coat adaptor complex relationship: part_of GO:0030118 ! clathrin coat [Term] id: GO:0030132 name: clathrin coat of coated pit namespace: cellular_component def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah] is_a: GO:0030118 ! clathrin coat is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005905 ! coated pit [Term] id: GO:0030133 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, or to destinations within or outside the cell." [GOC:mah] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" BROAD [] xref: NIF_Subcellular:sao885490876 is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0030134 name: ER to Golgi transport vesicle namespace: cellular_component alt_id: GO:0030138 def: "A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894] synonym: "COPII vesicle" RELATED [] synonym: "COPII-coated vesicle" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle" EXACT [] synonym: "endoplasmic reticulum-Golgi transport vesicle" EXACT [] synonym: "ER-Golgi transport vesicle" EXACT [] is_a: GO:0030133 ! transport vesicle is_a: GO:0030135 ! coated vesicle [Term] id: GO:0030135 name: coated vesicle namespace: cellular_component alt_id: GO:0005909 def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] xref: NIF_Subcellular:sao1985096626 is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0030136 name: clathrin-coated vesicle namespace: cellular_component def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] xref: NIF_Subcellular:sao148845161 is_a: GO:0030135 ! coated vesicle [Term] id: GO:0030137 name: COPI-coated vesicle namespace: cellular_component def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894] synonym: "coatomer" RELATED [] is_a: GO:0005798 ! Golgi-associated vesicle is_a: GO:0030135 ! coated vesicle [Term] id: GO:0030139 name: endocytic vesicle namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] subset: gosubset_prok synonym: "endocytotic transport vesicle" EXACT [] synonym: "endocytotic vesicle" EXACT [] xref: NIF_Subcellular:sao1362520468 is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0030140 name: trans-Golgi network transport vesicle namespace: cellular_component def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] synonym: "TGN transport vesicle" EXACT [] is_a: GO:0005798 ! Golgi-associated vesicle is_a: GO:0030133 ! transport vesicle is_a: GO:0030136 ! clathrin-coated vesicle [Term] id: GO:0030141 name: stored secretory granule namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. synonym: "secretory vesicle" BROAD [] is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0030142 name: Golgi to ER transport vesicle namespace: cellular_component def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah] synonym: "Golgi to endoplasmic reticulum transport vesicle" EXACT [] synonym: "Golgi-endoplasmic reticulum transport vesicle" EXACT [] synonym: "Golgi-ER transport vesicle" EXACT [] is_a: GO:0030133 ! transport vesicle is_a: GO:0030137 ! COPI-coated vesicle [Term] id: GO:0030143 name: inter-Golgi transport vesicle namespace: cellular_component alt_id: GO:0005807 def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah] xref: NIF_Subcellular:sao1382918459 is_a: GO:0030133 ! transport vesicle is_a: GO:0030137 ! COPI-coated vesicle [Term] id: GO:0030144 name: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155] synonym: "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "GnTV activity" EXACT [EC:2.4.1.155] synonym: "N-acetylglucosaminyltransferase V activity" RELATED [EC:2.4.1.155] synonym: "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] xref: EC:2.4.1.155 xref: MetaCyc:2.4.1.155-RXN xref: Reactome:20624 "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0030145 name: manganese ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] subset: gosubset_prok synonym: "manganese binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0030146 name: diuresis namespace: biological_process alt_id: GO:0003076 def: "OBSOLETE. The process of renal water excretion." [GOC:mah, GOC:mtg_cardio, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because its definition was inaccurate. synonym: "positive regulation of renal water excretion" EXACT [] synonym: "renal water excretion" BROAD [] xref: Wikipedia:Diuresis is_obsolete: true consider: GO:0035810 [Term] id: GO:0030147 name: natriuresis namespace: biological_process def: "OBSOLETE. The process of renal sodium excretion." [GOC:mtg_cardio, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because its definition was inaccurate. xref: Wikipedia:Natriuresis is_obsolete: true consider: GO:0035815 [Term] id: GO:0030148 name: sphingolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingolipid anabolism" EXACT [] synonym: "sphingolipid biosynthesis" EXACT [] synonym: "sphingolipid formation" EXACT [] synonym: "sphingolipid synthesis" EXACT [] xref: MetaCyc:PWY-5129 is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0046467 ! membrane lipid biosynthetic process [Term] id: GO:0030149 name: sphingolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingolipid breakdown" EXACT [] synonym: "sphingolipid catabolism" EXACT [] synonym: "sphingolipid degradation" EXACT [] is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0046466 ! membrane lipid catabolic process [Term] id: GO:0030150 name: protein import into mitochondrial matrix namespace: biological_process def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] synonym: "mitochondrial matrix protein import" EXACT [] synonym: "mitochondrial translocation" BROAD [] synonym: "protein transport into mitochondrial matrix" EXACT [] is_a: GO:0006626 ! protein targeting to mitochondrion is_a: GO:0065002 ! intracellular protein transmembrane transport [Term] id: GO:0030151 name: molybdenum ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai] subset: gosubset_prok synonym: "molybdenum binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0030152 name: bacteriocin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "bacteriocin anabolism" EXACT [] synonym: "bacteriocin biosynthesis" EXACT [] synonym: "bacteriocin formation" EXACT [] synonym: "bacteriocin synthesis" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0030651 ! peptide antibiotic biosynthetic process is_a: GO:0046224 ! bacteriocin metabolic process [Term] id: GO:0030153 name: bacteriocin immunity namespace: biological_process def: "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0009404 ! toxin metabolic process [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Cellular_differentiation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0030155 name: regulation of cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] subset: gosubset_prok synonym: "cell adhesion receptor regulator activity" RELATED [] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007155 ! cell adhesion [Term] id: GO:0030156 name: benzodiazepine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832] synonym: "benzodiazepine receptor ligand" NARROW [] synonym: "diazepam binding inhibitor activity" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0030157 name: pancreatic juice secretion namespace: biological_process def: "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0007589 ! body fluid secretion is_a: GO:0022600 ! digestive system process [Term] id: GO:0030158 name: protein xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26] synonym: "peptide O-xylosyltransferase activity" EXACT [] synonym: "UDP-D-xylose:core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:core protein xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-xylose-core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "uridine diphosphoxylose-core protein beta-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" EXACT [EC:2.4.2.26] xref: EC:2.4.2.26 xref: MetaCyc:2.4.2.26-RXN is_a: GO:0035252 ! UDP-xylosyltransferase activity [Term] id: GO:0030159 name: receptor signaling complex scaffold activity namespace: molecular_function def: "Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah] synonym: "receptor signaling complex scaffold protein activity" EXACT [] synonym: "receptor signalling complex scaffold activity" EXACT [] is_a: GO:0032947 ! protein complex scaffold [Term] id: GO:0030160 name: GKAP/Homer scaffold activity namespace: molecular_function def: "Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses." [PMID:10506216] synonym: "GKAP/Homer scaffold protein" NARROW [] synonym: "postsynaptic density scaffold protein" NARROW [] is_a: GO:0030159 ! receptor signaling complex scaffold activity [Term] id: GO:0030161 name: calpain inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai] comment: This term was made obsolete because it represents a regulator of a non-existent molecular function. is_obsolete: true replaced_by: GO:0010859 [Term] id: GO:0030162 name: regulation of proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] subset: gosubset_prok synonym: "regulation of peptidolysis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process relationship: regulates GO:0006508 ! proteolysis [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. subset: goslim_candida subset: goslim_pombe subset: gosubset_prok synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: Wikipedia:Protein_catabolism is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0030164 name: protein denaturation namespace: biological_process def: "Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds." [GOC:kd, ISBN:3110145359] subset: gosubset_prok xref: Wikipedia:Denaturation#Protein_denaturation is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0030165 name: PDZ domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] synonym: "DHR-domain binding" EXACT [] synonym: "GLGF-domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030166 name: proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proteoglycan anabolism" EXACT [] synonym: "proteoglycan biosynthesis" EXACT [] synonym: "proteoglycan formation" EXACT [] synonym: "proteoglycan synthesis" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0030167 name: proteoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proteoglycan breakdown" EXACT [] synonym: "proteoglycan catabolism" EXACT [] synonym: "proteoglycan degradation" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0009057 ! macromolecule catabolic process [Term] id: GO:0030168 name: platelet activation namespace: biological_process def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [http://www.graylab.ac.uk/omd/] synonym: "blood coagulation, platelet activation" EXACT [GOC:add, GOC:pde] xref: Reactome:1253233 "Platelet Activation" xref: Reactome:1280171 "Platelet Activation" xref: Reactome:1299042 "Platelet Activation" xref: Reactome:1326746 "Platelet Activation" xref: Reactome:1352850 "Platelet Activation" xref: Reactome:1373061 "Platelet Activation" xref: Reactome:1393077 "Platelet Activation" xref: Reactome:1417561 "Platelet Activation" xref: Reactome:1450653 "Platelet Activation" xref: Reactome:1471136 "Platelet Activation" xref: Reactome:1483145 "Platelet Activation" xref: Reactome:1497023 "Platelet Activation" xref: Reactome:1514410 "Platelet Activation" xref: Reactome:1521093 "Platelet Activation" xref: Reactome:1526984 "Platelet Activation" xref: Reactome:1532720 "Platelet Activation" xref: Reactome:1536119 "Platelet Activation" xref: Reactome:1538079 "Platelet Activation" xref: Reactome:1539373 "Platelet Activation" xref: Reactome:1540375 "Platelet Activation" xref: Reactome:76002 "Platelet Activation" is_a: GO:0001775 ! cell activation relationship: part_of GO:0007596 ! blood coagulation [Term] id: GO:0030169 name: low-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm." [GOC:mah] synonym: "LDL binding" EXACT [] is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0030170 name: pyridoxal phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0048037 ! cofactor binding is_a: GO:0070279 ! vitamin B6 binding [Term] id: GO:0030171 name: voltage-gated proton channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [ISBN:10615049] synonym: "voltage gated proton channel activity" EXACT [] synonym: "voltage-dependent proton channel activity" EXACT [] is_a: GO:0015252 ! hydrogen ion channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0030172 name: troponin C binding namespace: molecular_function def: "Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0030173 name: integral to Golgi membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] synonym: "Golgi integral membrane protein" RELATED [] is_a: GO:0031228 ! intrinsic to Golgi membrane is_a: GO:0031301 ! integral to organelle membrane [Term] id: GO:0030174 name: regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] subset: gosubset_prok synonym: "DNA replication licencing" EXACT [] synonym: "DNA replication licensing" EXACT [] is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: regulates GO:0006270 ! DNA-dependent DNA replication initiation [Term] id: GO:0030175 name: filopodium namespace: cellular_component alt_id: GO:0030028 def: "Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "microspike" EXACT [] xref: NIF_Subcellular:sao-1046371754 xref: Wikipedia:Filopodia is_a: GO:0042995 ! cell projection [Term] id: GO:0030176 name: integral to endoplasmic reticulum membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] synonym: "ER integral membrane protein" EXACT [] synonym: "integral to ER membrane" EXACT [] is_a: GO:0031227 ! intrinsic to endoplasmic reticulum membrane is_a: GO:0031301 ! integral to organelle membrane [Term] id: GO:0030177 name: positive regulation of Wnt receptor signaling pathway namespace: biological_process alt_id: GO:0045811 def: "Any process that activates or increases the frequency, rate or extent of Wnt receptor signaling pathway activity." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of frizzled signaling pathway" NARROW [] synonym: "activation of Wnt receptor signaling pathway" NARROW [] synonym: "positive regulation of frizzled signaling pathway" EXACT [] synonym: "positive regulation of frizzled signalling pathway" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway" EXACT [] synonym: "stimulation of frizzled signaling pathway" NARROW [] synonym: "stimulation of Wnt receptor signaling pathway" NARROW [] synonym: "up regulation of frizzled signaling pathway" EXACT [] synonym: "up regulation of Wnt receptor signaling pathway" EXACT [] synonym: "up-regulation of frizzled signaling pathway" EXACT [] synonym: "up-regulation of Wnt receptor signaling pathway" EXACT [] synonym: "upregulation of frizzled signaling pathway" EXACT [] synonym: "upregulation of Wnt receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway relationship: positively_regulates GO:0016055 ! Wnt receptor signaling pathway [Term] id: GO:0030178 name: negative regulation of Wnt receptor signaling pathway namespace: biological_process alt_id: GO:0045810 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt receptor signaling pathway activity." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of frizzled signaling pathway" EXACT [] synonym: "down regulation of Wnt receptor signaling pathway" EXACT [] synonym: "down-regulation of frizzled signaling pathway" EXACT [] synonym: "down-regulation of Wnt receptor signaling pathway" EXACT [] synonym: "downregulation of frizzled signaling pathway" EXACT [] synonym: "downregulation of Wnt receptor signaling pathway" EXACT [] synonym: "inhibition of frizzled signaling pathway" NARROW [] synonym: "inhibition of Wnt receptor signaling pathway" NARROW [] synonym: "negative regulation of frizzled signaling pathway" EXACT [] synonym: "negative regulation of frizzled signalling pathway" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway relationship: negatively_regulates GO:0016055 ! Wnt receptor signaling pathway [Term] id: GO:0030180 name: solute:solute exchange namespace: biological_process def: "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction." [GOC:mah] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0006810 replaced_by: GO:0015300 [Term] id: GO:0030181 name: sodium:calcium exchange namespace: biological_process def: "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true replaced_by: GO:0006814 replaced_by: GO:0006816 consider: GO:0005432 [Term] id: GO:0030182 name: neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0030183 name: B cell differentiation namespace: biological_process alt_id: GO:0042115 def: "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000022, GOC:mah, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was moved. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B cell development" RELATED [GOC:add] synonym: "B lymphocyte differentiation" EXACT [] synonym: "B-cell differentiation" EXACT [] synonym: "B-lymphocyte differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042113 ! B cell activation [Term] id: GO:0030184 name: nitric oxide transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0030185 name: nitric oxide transport namespace: biological_process def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0030186 name: melatonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "melatonin metabolism" EXACT [] is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0030187 name: melatonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "melatonin anabolism" EXACT [] synonym: "melatonin biosynthesis" EXACT [] synonym: "melatonin formation" EXACT [] synonym: "melatonin synthesis" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046219 ! indolalkylamine biosynthetic process [Term] id: GO:0030188 name: chaperone regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of a molecular chaperone." [GOC:mah] comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030189 name: chaperone activator activity namespace: molecular_function def: "OBSOLETE. Increases the activity of a molecular chaperone." [GOC:mah] comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. subset: gosubset_prok is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030190 name: chaperone inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone." [GOC:mah] comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030191 name: Hsp70/Hsc70 protein inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'. is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030192 name: Hsp70/Hsc70 protein regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'. subset: gosubset_prok is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030193 name: regulation of blood coagulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050818 ! regulation of coagulation is_a: GO:0061041 ! regulation of wound healing relationship: regulates GO:0007596 ! blood coagulation [Term] id: GO:0030194 name: positive regulation of blood coagulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "activation of blood coagulation" NARROW [] synonym: "stimulation of blood coagulation" NARROW [] synonym: "up regulation of blood coagulation" EXACT [] synonym: "up-regulation of blood coagulation" EXACT [] synonym: "upregulation of blood coagulation" EXACT [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050820 ! positive regulation of coagulation relationship: positively_regulates GO:0007596 ! blood coagulation [Term] id: GO:0030195 name: negative regulation of blood coagulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "down regulation of blood coagulation" EXACT [] synonym: "down-regulation of blood coagulation" EXACT [] synonym: "downregulation of blood coagulation" EXACT [] synonym: "inhibition of blood coagulation" NARROW [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050819 ! negative regulation of coagulation relationship: negatively_regulates GO:0007596 ! blood coagulation [Term] id: GO:0030196 name: cyanide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide." [EC:4.2.1.66, RHEA:21723] synonym: "formamide dehydratase activity" EXACT [EC:4.2.1.66] synonym: "formamide hydro-lyase (cyanide-forming)" EXACT [EC:4.2.1.66] synonym: "formamide hydro-lyase activity" EXACT [EC:4.2.1.66] xref: EC:4.2.1.66 xref: KEGG:R01408 xref: MetaCyc:CYANIDE-HYDRATASE-RXN xref: RHEA:21723 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0030197 name: extracellular matrix constituent, lubricant activity namespace: molecular_function def: "Functions as a lubricant for an extracellular matrix, such as a mucous membrane." [GOC:mah] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030198 name: extracellular matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "extracellular matrix organisation" EXACT [GOC:curators] synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] is_a: GO:0043062 ! extracellular structure organization [Term] id: GO:0030199 name: collagen fibril organization namespace: biological_process def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194] synonym: "collagen fibril organisation" EXACT [GOC:curators] synonym: "fibrillar collagen organization" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization [Term] id: GO:0030200 name: heparan sulfate proteoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha1->4 linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "heparan sulfate proteoglycan breakdown" EXACT [] synonym: "heparan sulfate proteoglycan catabolism" EXACT [] synonym: "heparan sulfate proteoglycan degradation" EXACT [] synonym: "heparan sulphate proteoglycan catabolic process" EXACT [] synonym: "heparan sulphate proteoglycan catabolism" EXACT [] synonym: "heparin proteoglycan catabolic process" RELATED [] is_a: GO:0030167 ! proteoglycan catabolic process is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0030201 name: heparan sulfate proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha1->4 linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "heparan sulfate proteoglycan metabolism" EXACT [] synonym: "heparan sulphate proteoglycan metabolic process" EXACT [] synonym: "heparan sulphate proteoglycan metabolism" EXACT [] synonym: "heparin proteoglycan metabolic process" RELATED [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0030202 name: heparin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "heparan sulfate metabolic process" RELATED [] synonym: "heparin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0030203 name: glycosaminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties." [ISBN:0192800981] subset: gosubset_prok synonym: "glycosaminoglycan metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0030204 name: chondroitin sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chondroitin sulfate metabolism" EXACT [] synonym: "chondroitin sulphate metabolic process" EXACT [] synonym: "chondroitin sulphate metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process relationship: part_of GO:0050654 ! chondroitin sulfate proteoglycan metabolic process [Term] id: GO:0030205 name: dermatan sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chondroitin sulfate B metabolic process" EXACT [] synonym: "chondroitin sulfate B metabolism" EXACT [] synonym: "dermatan sulfate metabolism" EXACT [] synonym: "dermatan sulphate metabolic process" EXACT [] synonym: "dermatan sulphate metabolism" EXACT [] is_a: GO:0030204 ! chondroitin sulfate metabolic process relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process [Term] id: GO:0030206 name: chondroitin sulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chondroitin sulfate anabolism" EXACT [] synonym: "chondroitin sulfate biosynthesis" EXACT [] synonym: "chondroitin sulfate formation" EXACT [] synonym: "chondroitin sulfate synthesis" EXACT [] synonym: "chondroitin sulphate biosynthesis" EXACT [] synonym: "chondroitin sulphate biosynthetic process" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030204 ! chondroitin sulfate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process [Term] id: GO:0030207 name: chondroitin sulfate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chondroitin sulfate breakdown" EXACT [] synonym: "chondroitin sulfate catabolism" EXACT [] synonym: "chondroitin sulfate degradation" EXACT [] synonym: "chondroitin sulphate catabolic process" EXACT [] synonym: "chondroitin sulphate catabolism" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030204 ! chondroitin sulfate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0030208 name: dermatan sulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chondroitin sulfate B biosynthesis" EXACT [] synonym: "chondroitin sulfate B biosynthetic process" EXACT [] synonym: "dermatan sulfate anabolism" EXACT [] synonym: "dermatan sulfate biosynthesis" EXACT [] synonym: "dermatan sulfate formation" EXACT [] synonym: "dermatan sulfate synthesis" EXACT [] synonym: "dermatan sulphate biosynthesis" EXACT [] synonym: "dermatan sulphate biosynthetic process" EXACT [] is_a: GO:0030205 ! dermatan sulfate metabolic process is_a: GO:0030206 ! chondroitin sulfate biosynthetic process relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process [Term] id: GO:0030209 name: dermatan sulfate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chondroitin sulfate B catabolic process" EXACT [] synonym: "chondroitin sulfate B catabolism" EXACT [] synonym: "dermatan sulfate breakdown" EXACT [] synonym: "dermatan sulfate catabolism" EXACT [] synonym: "dermatan sulfate degradation" EXACT [] synonym: "dermatan sulphate catabolic process" EXACT [] synonym: "dermatan sulphate catabolism" EXACT [] is_a: GO:0030205 ! dermatan sulfate metabolic process is_a: GO:0030207 ! chondroitin sulfate catabolic process [Term] id: GO:0030210 name: heparin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "heparan sulfate biosynthetic process" RELATED [] synonym: "heparin anabolism" EXACT [] synonym: "heparin biosynthesis" EXACT [] synonym: "heparin formation" EXACT [] synonym: "heparin synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030202 ! heparin metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0030211 name: heparin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "heparan sulfate catabolic process" RELATED [] synonym: "heparin breakdown" EXACT [] synonym: "heparin catabolism" EXACT [] synonym: "heparin degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030202 ! heparin metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0030212 name: hyaluronan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hyaluronan metabolism" EXACT [] is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0030213 name: hyaluronan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hyaluronan anabolism" EXACT [] synonym: "hyaluronan biosynthesis" EXACT [] synonym: "hyaluronan formation" EXACT [] synonym: "hyaluronan synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030212 ! hyaluronan metabolic process [Term] id: GO:0030214 name: hyaluronan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hyaluronan breakdown" EXACT [] synonym: "hyaluronan catabolism" EXACT [] synonym: "hyaluronan degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030212 ! hyaluronan metabolic process [Term] id: GO:0030215 name: semaphorin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with semaphorin receptors." [GOC:ceb, PMID:12001990] synonym: "plexin binding" NARROW [] synonym: "plexin ligand" NARROW [] synonym: "semaphorin receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0030216 name: keratinocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb] synonym: "keratinocyte cell differentiation" EXACT [] is_a: GO:0009913 ! epidermal cell differentiation is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030217 name: T cell differentiation namespace: biological_process alt_id: GO:0042112 alt_id: GO:0046652 def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was moved. Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development" RELATED [GOC:add] synonym: "T lymphocyte differentiation" EXACT [] synonym: "T-cell differentiation" EXACT [] synonym: "T-lymphocyte differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042110 ! T cell activation [Term] id: GO:0030218 name: erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] synonym: "erythrocyte cell differentiation" EXACT [] synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "RBC differentiation" EXACT [CL:0000232] synonym: "red blood cell differentiation" EXACT [CL:0000232] xref: Wikipedia:Erythropoiesis is_a: GO:0030099 ! myeloid cell differentiation relationship: part_of GO:0034101 ! erythrocyte homeostasis [Term] id: GO:0030219 name: megakaryocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah] synonym: "megakaryocyte cell differentiation" EXACT [] is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0030220 name: platelet formation namespace: biological_process def: "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194] synonym: "platelet extrusion" EXACT systematic_synonym [GOC:curators] is_a: GO:0030099 ! myeloid cell differentiation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0030221 name: basophil differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jid, GOC:mah] synonym: "basophil cell differentiation" EXACT [] is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030222 name: eosinophil differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:mah] synonym: "eosinophil cell differentiation" EXACT [] is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030223 name: neutrophil differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah] synonym: "neutrophil cell differentiation" EXACT [] synonym: "neutrophil granulocyte differentiation" EXACT [GOC:yaf] synonym: "neutrophil granulocytopoiesis" EXACT [GOC:yaf] is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030224 name: monocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah] synonym: "monocyte cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030225 name: macrophage differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "macrophage cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030226 name: apolipoprotein receptor activity namespace: molecular_function def: "Combining with an apolipoprotein, the protein component of a lipoprotein, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004872 ! receptor activity is_a: GO:0034185 ! apolipoprotein binding [Term] id: GO:0030227 name: apolipoprotein E receptor activity namespace: molecular_function def: "OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity." [GOC:mah] comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid). synonym: "ApoE receptor" EXACT [] is_obsolete: true replaced_by: GO:0030229 [Term] id: GO:0030228 name: lipoprotein particle receptor activity namespace: molecular_function def: "Combining with a lipoprotein particle to initiate a change in cell activity. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [CHEBI:6495, GOC:mah] subset: gosubset_prok synonym: "lipoprotein receptor activity" EXACT [GOC:dph] synonym: "plasma lipoprotein particle receptor activity" EXACT [GOC:BHF] is_a: GO:0004888 ! transmembrane receptor activity is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0030229 name: very-low-density lipoprotein particle receptor activity namespace: molecular_function def: "Combining with a very-low-density lipoprotein particle to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "apolipoprotein E receptor activity" RELATED [GOC:rl] synonym: "very-low-density lipoprotein receptor activity" EXACT [GOC:dph] synonym: "VLDL receptor" EXACT [] xref: Wikipedia:VLDL_receptor is_a: GO:0030228 ! lipoprotein particle receptor activity is_a: GO:0034189 ! very-low-density lipoprotein particle binding [Term] id: GO:0030232 name: insulin control element activator complex namespace: cellular_component def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390] synonym: "ICE activator complex" EXACT [] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0030233 name: deoxynucleotide transmembrane transporter activity namespace: molecular_function def: "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231] is_a: GO:0015215 ! nucleotide transmembrane transporter activity [Term] id: GO:0030234 name: enzyme regulator activity namespace: molecular_function def: "Modulates the activity of an enzyme." [GOC:mah] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "catalytic regulator activity" EXACT [GOC:dph] synonym: "enzyme modulator" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0030235 name: nitric-oxide synthase regulator activity namespace: molecular_function def: "Modulates the activity of nitric oxide synthase." [GOC:mah] comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'. synonym: "nitric oxide synthase regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0030237 name: female sex determination namespace: biological_process def: "The specification of female sex of an individual organism." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0030238 name: male sex determination namespace: biological_process def: "The specification of male sex of an individual organism." [GOC:mah] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0030239 name: myofibril assembly namespace: biological_process def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0031032 ! actomyosin structure organization relationship: part_of GO:0055002 ! striated muscle cell development [Term] id: GO:0030240 name: skeletal muscle thin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] is_a: GO:0007015 ! actin filament organization relationship: part_of GO:0014866 ! skeletal myofibril assembly [Term] id: GO:0030241 name: skeletal muscle myosin thick filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] is_a: GO:0071688 ! striated muscle myosin thick filament assembly relationship: part_of GO:0014866 ! skeletal myofibril assembly [Term] id: GO:0030242 name: peroxisome degradation namespace: biological_process def: "The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [PMID:10547367] synonym: "pexophagy" EXACT [] is_a: GO:0006914 ! autophagy is_a: GO:0007031 ! peroxisome organization [Term] id: GO:0030243 name: cellulose metabolic process namespace: biological_process alt_id: GO:0016177 def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cellulose metabolism" EXACT [] is_a: GO:0044042 ! glucan metabolic process [Term] id: GO:0030244 name: cellulose biosynthetic process namespace: biological_process alt_id: GO:0016178 def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cellulose anabolism" EXACT [] synonym: "cellulose biosynthesis" EXACT [] synonym: "cellulose formation" EXACT [] synonym: "cellulose synthesis" EXACT [] xref: MetaCyc:PWY-1001 is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0030243 ! cellulose metabolic process [Term] id: GO:0030245 name: cellulose catabolic process namespace: biological_process alt_id: GO:0016179 def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cellulose breakdown" EXACT [] synonym: "cellulose catabolism" EXACT [] synonym: "cellulose degradation" EXACT [] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0030243 ! cellulose metabolic process [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function def: "Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "selectin" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0030247 name: polysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any polysaccharide, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages." [GOC:mah] subset: gosubset_prok is_a: GO:0001871 ! pattern binding is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0030248 name: cellulose binding namespace: molecular_function def: "Interacting selectively and non-covalently with cellulose." [GOC:mah] subset: gosubset_prok is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0030249 name: guanylate cyclase regulator activity namespace: molecular_function def: "Modulates the activity of guanylate cyclase." [GOC:mah] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0030250 name: guanylate cyclase activator activity namespace: molecular_function def: "Increases the activity of guanylate cyclase." [GOC:mah] synonym: "guanylin" NARROW [] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0010853 ! cyclase activator activity is_a: GO:0030249 ! guanylate cyclase regulator activity [Term] id: GO:0030251 name: guanylate cyclase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of guanylate cyclase." [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0010852 ! cyclase inhibitor activity is_a: GO:0030249 ! guanylate cyclase regulator activity [Term] id: GO:0030252 name: growth hormone secretion namespace: biological_process def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah] synonym: "somatotropin secretion" EXACT [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030253 name: protein secretion by the type I secretion system namespace: biological_process def: "The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'. synonym: "protein secretion by the TOSS" EXACT [] synonym: "protein secretion by the type I protein secretion system" EXACT [] synonym: "type I protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0030254 name: protein secretion by the type III secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. subset: gosubset_prok synonym: "protein secretion by the T3S" EXACT [] synonym: "protein secretion by the T3SS" EXACT [] synonym: "protein secretion by the TTSS" EXACT [] synonym: "protein secretion by the type III protein secretion system" EXACT [] synonym: "type III protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0030255 name: protein secretion by the type IV secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'. subset: gosubset_prok synonym: "protein secretion by the T4SS" EXACT [] synonym: "protein secretion by the type IV protein secretion system" EXACT [] synonym: "type IV protein secretion system" NARROW [] is_a: GO:0009306 ! protein secretion is_a: GO:0044097 ! secretion by the type IV secretion system is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0030256 name: type I protein secretion system complex namespace: cellular_component def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447] subset: gosubset_prok synonym: "ABC translocator complex" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0030257 name: type III protein secretion system complex namespace: cellular_component def: "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447] subset: gosubset_prok synonym: "T3SS complex" EXACT [] synonym: "TTSS complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0030258 name: lipid modification namespace: biological_process def: "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah] subset: gosubset_prok is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0030259 name: lipid glycosylation namespace: biological_process def: "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] subset: gosubset_prok is_a: GO:0030258 ! lipid modification is_a: GO:0070085 ! glycosylation [Term] id: GO:0030260 name: entry into host cell namespace: biological_process def: "The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:njm] subset: gosubset_prok synonym: "host cell invasion" EXACT [] xref: Reactome:173107 "Binding and entry of HIV virion" is_a: GO:0044409 ! entry into host is_a: GO:0051806 ! entry into cell of other organism involved in symbiotic interaction [Term] id: GO:0030261 name: chromosome condensation namespace: biological_process alt_id: GO:0000068 def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] is_a: GO:0006323 ! DNA packaging is_a: GO:0051276 ! chromosome organization [Term] id: GO:0030262 name: apoptotic nuclear change namespace: biological_process def: "A process that is carried out at the cellular level which results in the disassembly of the nucleus and contributes to apoptosis." [GOC:mah] is_a: GO:0006921 ! cellular component disassembly involved in apoptosis [Term] id: GO:0030263 name: apoptotic chromosome condensation namespace: biological_process def: "The compaction of chromatin during apoptosis." [GOC:mah] synonym: "pyknosis" EXACT [] xref: Wikipedia:Pyknosis is_a: GO:0030261 ! chromosome condensation relationship: part_of GO:0030262 ! apoptotic nuclear change [Term] id: GO:0030264 name: nuclear fragmentation involved in apoptotic nuclear change namespace: biological_process def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:tb, ISBN:0721639976] synonym: "apoptotic nuclear fragmentation" EXACT [] synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb] synonym: "nucleus fragmentation" EXACT [] is_a: GO:0071763 ! nuclear membrane organization relationship: part_of GO:0030262 ! apoptotic nuclear change [Term] id: GO:0030265 name: rhodopsin mediated G-protein signaling, coupled to IP3 second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of light impinging on rhodopsin molecules in a photoreceptor cell, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:mah] synonym: "rhodopsin mediated G protein signaling, coupled to IP3 second messenger" EXACT [] synonym: "rhodopsin mediated G protein signalling, coupled to IP3 second messenger" EXACT [] synonym: "rhodopsin mediated G-protein signalling, coupled to IP3 second messenger" EXACT [] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0030266 name: quinate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: quinate + NAD+ = 5-dehydroquinate + NADH + H+." [EC:1.1.1.24] synonym: "quinate:NAD oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinate:NAD(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinic dehydrogenase activity" EXACT [EC:1.1.1.24] xref: EC:1.1.1.24 xref: MetaCyc:QUINATE-5-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030267 name: glyoxylate reductase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79] subset: gosubset_prok synonym: "glycolate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.79] synonym: "glyoxylate reductase (NADP+)" EXACT [EC:1.1.1.79] synonym: "NADPH-glyoxylate reductase activity" EXACT [EC:1.1.1.79] xref: EC:1.1.1.79 xref: MetaCyc:GLYOXYLATE-REDUCTASE-NADP+-RXN xref: Reactome:21773 "glyoxylate reductase (NADP) activity" xref: Wikipedia:Glyoxylate_reductase_(NADP+) is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030268 name: methylenetetrahydromethanopterin dehydrogenase activity namespace: molecular_function alt_id: GO:0018536 def: "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F(420)." [EC:1.5.99.9, RHEA:16724] subset: gosubset_prok synonym: "5,10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9] synonym: "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.9] synonym: "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9] xref: EC:1.5.99.9 xref: KEGG:R04456 xref: MetaCyc:1.5.99.9-RXN xref: RHEA:16724 xref: UM-BBD_reactionID:r0348 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0030269 name: tetrahydromethanopterin S-methyltransferase activity namespace: molecular_function alt_id: GO:0018709 def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [EC:2.1.1.86, RHEA:17588] subset: gosubset_prok synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "tetrahydromethanopterin methyltransferase activity" EXACT [EC:2.1.1.86] xref: EC:2.1.1.86 xref: KEGG:R04347 xref: MetaCyc:2.1.1.86-RXN xref: RHEA:17588 xref: UM-BBD_reactionID:r0355 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042086 ! 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity [Term] id: GO:0030270 name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity namespace: molecular_function alt_id: GO:0018714 def: "Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran." [EC:2.3.1.101, RHEA:18064] subset: gosubset_prok synonym: "formylmethanofuran-tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "FTR" RELATED [EC:2.3.1.101] synonym: "N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity" EXACT [EC:2.3.1.101] xref: EC:2.3.1.101 xref: KEGG:R03390 xref: MetaCyc:2.3.1.101-RXN xref: RHEA:18064 xref: UM-BBD_reactionID:r0346 is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0030271 name: chymase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [EC:3.4.21.39] comment: This term was made obsolete because it represents a gene product. synonym: "mast cell protease I activity" NARROW [EC:3.4.21.39] synonym: "mast cell serine proteinase" NARROW [EC:3.4.21.39] synonym: "SK protease activity" EXACT [EC:3.4.21.39] synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39] synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39] synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39] xref: EC:3.4.21.39 xref: MetaCyc:3.4.21.39-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030272 name: 5-formyltetrahydrofolate cyclo-ligase activity namespace: molecular_function alt_id: GO:0019006 def: "Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate." [EC:6.3.3.2, RHEA:10491] subset: gosubset_prok synonym: "5,10-methenyltetrahydrofolate synthetase activity" EXACT [EC:6.3.3.2] synonym: "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.2] synonym: "5-formyltetrahydrofolate cyclodehydrase" BROAD [EC:6.3.3.2] synonym: "5-Formyltetrahydrofolate cyclodehydrase activity" EXACT [EC:6.3.3.2] synonym: "formyltetrahydrofolic cyclodehydrase activity" EXACT [EC:6.3.3.2] synonym: "methenyl-THF synthetase activity" EXACT [EC:6.3.3.2] xref: EC:6.3.3.2 xref: KEGG:R02301 xref: MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN xref: RHEA:10491 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0030273 name: melanin-concentrating hormone receptor activity namespace: molecular_function def: "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah] synonym: "MCH receptor" EXACT [] is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0030274 name: LIM domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030275 name: LRR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030276 name: clathrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005515 ! protein binding [Term] id: GO:0030277 name: maintenance of gastrointestinal epithelium namespace: biological_process def: "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah] is_a: GO:0010669 ! epithelial structure maintenance is_a: GO:0022600 ! digestive system process [Term] id: GO:0030278 name: regulation of ossification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone formation." [GOC:go_curators] synonym: "regulation of bone biosynthesis" EXACT [] synonym: "regulation of bone formation" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0001503 ! ossification [Term] id: GO:0030279 name: negative regulation of ossification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation." [GOC:go_curators] synonym: "down regulation of ossification" EXACT [] synonym: "down-regulation of ossification" EXACT [] synonym: "downregulation of ossification" EXACT [] synonym: "inhibition of ossification" NARROW [] synonym: "negative regulation of bone biosynthesis" EXACT [] synonym: "negative regulation of bone formation" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0001503 ! ossification [Term] id: GO:0030280 name: structural constituent of epidermis namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0030281 name: structural constituent of cutaneous appendage namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437] is_a: GO:0030280 ! structural constituent of epidermis [Term] id: GO:0030282 name: bone mineralization namespace: biological_process def: "The deposition of calcium phosphate in bone tissue." [GOC:mah] synonym: "bone calcification" NARROW [] is_a: GO:0031214 ! biomineral tissue development relationship: part_of GO:0001503 ! ossification [Term] id: GO:0030283 name: testosterone dehydrogenase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51] subset: gosubset_prok synonym: "17beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] synonym: "3(or 17)beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.51] synonym: "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase" BROAD [EC:1.1.1.51] synonym: "3beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] synonym: "3beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.51] synonym: "beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] xref: EC:1.1.1.51 xref: MetaCyc:1.1.1.51-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030284 name: estrogen receptor activity namespace: molecular_function def: "Combining with estrogen to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0003707 ! steroid hormone receptor activity [Term] id: GO:0030285 name: integral to synaptic vesicle membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] is_a: GO:0031301 ! integral to organelle membrane is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0044456 ! synapse part relationship: part_of GO:0030672 ! synaptic vesicle membrane [Term] id: GO:0030286 name: dynein complex namespace: cellular_component def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] is_a: GO:0005875 ! microtubule associated complex [Term] id: GO:0030287 name: cell wall-bounded periplasmic space namespace: cellular_component def: "The region between the plasma membrane and the cell wall, as found in organisms such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "cell wall bounded periplasmic space" EXACT [] synonym: "cell wall-enclosed periplasmic space" EXACT [] is_a: GO:0042597 ! periplasmic space [Term] id: GO:0030288 name: outer membrane-bounded periplasmic space namespace: cellular_component def: "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "outer membrane bounded periplasmic space" EXACT [] synonym: "outer membrane-enclosed periplasmic space" EXACT [] xref: Wikipedia:Periplasmic_space is_a: GO:0042597 ! periplasmic space is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0030289 name: protein phosphatase 4 complex namespace: cellular_component def: "The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit." [PMID:10026142] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030290 name: sphingolipid activator protein activity namespace: molecular_function def: "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "saposin" NARROW [] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0030291 name: protein serine/threonine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity [Term] id: GO:0030292 name: protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity [Term] id: GO:0030293 name: transmembrane receptor protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity is_a: GO:0030547 ! receptor inhibitor activity [Term] id: GO:0030294 name: receptor signaling protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase." [GOC:mah] synonym: "receptor signalling protein tyrosine kinase inhibitor activity" EXACT [] is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity [Term] id: GO:0030295 name: protein kinase activator activity namespace: molecular_function def: "Increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0019209 ! kinase activator activity is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0030296 name: protein tyrosine kinase activator activity namespace: molecular_function def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0030295 ! protein kinase activator activity [Term] id: GO:0030297 name: transmembrane receptor protein tyrosine kinase activator activity namespace: molecular_function def: "Increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] is_a: GO:0030296 ! protein tyrosine kinase activator activity is_a: GO:0030546 ! receptor activator activity [Term] id: GO:0030298 name: receptor signaling protein tyrosine kinase activator activity namespace: molecular_function def: "Increases the activity of a receptor signaling protein tyrosine kinase." [GOC:mah] synonym: "receptor signalling protein tyrosine kinase activator activity" EXACT [] is_a: GO:0030296 ! protein tyrosine kinase activator activity [Term] id: GO:0030299 name: intestinal cholesterol absorption namespace: biological_process def: "Uptake of cholesterol into the blood by absorption from the small intestine." [GOC:mah] is_a: GO:0030301 ! cholesterol transport is_a: GO:0050892 ! intestinal absorption relationship: part_of GO:0044241 ! lipid digestion [Term] id: GO:0030300 name: regulation of intestinal cholesterol absorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption." [GOC:mah, PMID:11099417] is_a: GO:0032374 ! regulation of cholesterol transport is_a: GO:0044058 ! regulation of digestive system process relationship: regulates GO:0030299 ! intestinal cholesterol absorption [Term] id: GO:0030301 name: cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015918 ! sterol transport [Term] id: GO:0030302 name: deoxynucleotide transport namespace: biological_process def: "The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0006862 ! nucleotide transport [Term] id: GO:0030303 name: stromelysin 2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [EC:3.4.24.17, EC:3.4.24.22] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 10 activity" EXACT [EC:3.4.24.22] synonym: "MMP-10" EXACT [] synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22] synonym: "transin 2 activity" EXACT [EC:3.4.24.22] xref: EC:3.4.24.22 xref: MetaCyc:3.4.24.22-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030304 name: trypsin inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. subset: gosubset_prok is_obsolete: true replaced_by: GO:0004867 [Term] id: GO:0030305 name: heparanase activity namespace: molecular_function def: "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150] synonym: "heparinase activity" RELATED [] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0030306 name: ADP-ribosylation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ARF binding" EXACT [] is_a: GO:0031267 ! small GTPase binding [Term] id: GO:0030307 name: positive regulation of cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell growth." [GOC:go_curators] subset: gosubset_prok synonym: "activation of cell growth" NARROW [] synonym: "stimulation of cell growth" NARROW [] synonym: "up regulation of cell growth" EXACT [] synonym: "up-regulation of cell growth" EXACT [] synonym: "upregulation of cell growth" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048522 ! positive regulation of cellular process relationship: part_of GO:0045793 ! positive regulation of cell size relationship: positively_regulates GO:0016049 ! cell growth [Term] id: GO:0030308 name: negative regulation of cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell growth." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of cell growth" EXACT [] synonym: "down-regulation of cell growth" EXACT [] synonym: "downregulation of cell growth" EXACT [] synonym: "inhibition of cell growth" NARROW [] xref: Reactome:110491 "DRheb is inhibited by the TSC1/2 complex" is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0016049 ! cell growth relationship: part_of GO:0045792 ! negative regulation of cell size [Term] id: GO:0030309 name: poly-N-acetyllactosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] subset: gosubset_prok synonym: "poly-N-acetyllactosamine metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0030310 name: poly-N-acetyllactosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] subset: gosubset_prok synonym: "poly-N-acetyllactosamine breakdown" EXACT [] synonym: "poly-N-acetyllactosamine catabolism" EXACT [] synonym: "poly-N-acetyllactosamine degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0030311 name: poly-N-acetyllactosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] subset: gosubset_prok synonym: "poly-N-acetyllactosamine anabolism" EXACT [] synonym: "poly-N-acetyllactosamine biosynthesis" EXACT [] synonym: "poly-N-acetyllactosamine formation" EXACT [] synonym: "poly-N-acetyllactosamine synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:go_curators] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0044464 ! cell part relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0030313 name: cell envelope namespace: cellular_component def: "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Cell_envelope is_a: GO:0031975 ! envelope [Term] id: GO:0030314 name: junctional membrane complex namespace: cellular_component def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622] synonym: "triad junction" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0016528 ! sarcoplasm [Term] id: GO:0030315 name: T-tubule namespace: cellular_component def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194] synonym: "transverse tubule" EXACT [] synonym: "triad" RELATED [] xref: Wikipedia:T-tubule is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0042383 ! sarcolemma [Term] id: GO:0030316 name: osteoclast differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12161749] synonym: "osteoclast cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030317 name: sperm motility namespace: biological_process def: "Any process involved in the controlled movement of a sperm cell." [GOC:jl] synonym: "sperm movement" EXACT [] xref: Wikipedia:Sperm_motility is_a: GO:0048870 ! cell motility [Term] id: GO:0030318 name: melanocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah] synonym: "melanocyte cell differentiation" EXACT [] synonym: "melanophore differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0030319 name: cellular di-, tri-valent inorganic anion homeostasis namespace: biological_process def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah] comment: This term was made obsolete because it has been split. is_obsolete: true consider: GO:0072501 consider: GO:0072502 [Term] id: GO:0030320 name: cellular monovalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah] is_a: GO:0030002 ! cellular anion homeostasis is_a: GO:0055083 ! monovalent inorganic anion homeostasis [Term] id: GO:0030321 name: transepithelial chloride transport namespace: biological_process def: "The directed movement of chloride ions from one side of an epithelium to the other." [GOC:mah] is_a: GO:0006821 ! chloride transport is_a: GO:0070633 ! transepithelial transport [Term] id: GO:0030322 name: stabilization of membrane potential namespace: biological_process def: "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0030323 name: respiratory tube development namespace: biological_process def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! organ development [Term] id: GO:0030324 name: lung development namespace: biological_process def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048] is_a: GO:0048513 ! organ development relationship: part_of GO:0030323 ! respiratory tube development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0030325 name: adrenal gland development namespace: biological_process def: "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh] synonym: "interrenal gland" RELATED [] is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0030326 name: embryonic limb morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172] is_a: GO:0035108 ! limb morphogenesis is_a: GO:0035113 ! embryonic appendage morphogenesis [Term] id: GO:0030327 name: prenylated protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah] subset: gosubset_prok synonym: "prenylated protein breakdown" EXACT [] synonym: "prenylated protein catabolism" EXACT [] synonym: "prenylated protein degradation" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0030328 name: prenylcysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai] subset: gosubset_prok synonym: "prenylcysteine breakdown" EXACT [] synonym: "prenylcysteine catabolism" EXACT [] synonym: "prenylcysteine degradation" EXACT [] is_a: GO:0030329 ! prenylcysteine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process [Term] id: GO:0030329 name: prenylcysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai, PMID:16627894] subset: gosubset_prok synonym: "prenylcysteine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0030330 name: DNA damage response, signal transduction by p53 class mediator namespace: biological_process alt_id: GO:0006976 def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators] synonym: "DNA damage response, activation of p53" RELATED [] synonym: "p53 signaling pathway" RELATED [GOC:mah, GOC:vk] synonym: "p53-mediated DNA damage response" BROAD [] synonym: "TP53 signaling pathway" RELATED [GOC:mah, GOC:vk] is_a: GO:0042770 ! signal transduction in response to DNA damage is_a: GO:0072331 ! signal transduction by p53 class mediator [Term] id: GO:0030331 name: estrogen receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an estrogen receptor." [GOC:ai] is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0030332 name: cyclin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] is_a: GO:0005515 ! protein binding [Term] id: GO:0030334 name: regulation of cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] is_a: GO:2000145 ! regulation of cell motility relationship: regulates GO:0016477 ! cell migration [Term] id: GO:0030335 name: positive regulation of cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] subset: gosubset_prok synonym: "activation of cell migration" NARROW [] synonym: "stimulation of cell migration" NARROW [] synonym: "up regulation of cell migration" EXACT [] synonym: "up-regulation of cell migration" EXACT [] synonym: "upregulation of cell migration" EXACT [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000147 ! positive regulation of cell motility relationship: positively_regulates GO:0016477 ! cell migration [Term] id: GO:0030336 name: negative regulation of cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "down regulation of cell migration" EXACT [] synonym: "down-regulation of cell migration" EXACT [] synonym: "downregulation of cell migration" EXACT [] synonym: "inhibition of cell migration" NARROW [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000146 ! negative regulation of cell motility relationship: negatively_regulates GO:0016477 ! cell migration [Term] id: GO:0030337 name: DNA polymerase processivity factor activity namespace: molecular_function def: "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839] subset: gosubset_prok synonym: "processivity clamp" EXACT [] synonym: "sliding clamp" EXACT [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0030338 name: CMP-N-acetylneuraminate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O." [EC:1.14.18.2] comment: Note that this was EC:1.14.13.45. synonym: "CMP-N-acetylneuraminate hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)" EXACT [EC:1.14.18.2] synonym: "CMP-N-acetylneuraminic acid hydroxylase activity" EXACT [] synonym: "CMP-Neu5Ac hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "cytidine monophosphoacetylneuraminate monooxygenase activity" EXACT [EC:1.14.18.2] synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "N-acetylneuraminic monooxygenase activity" EXACT [EC:1.14.18.2] xref: EC:1.14.18.2 xref: MetaCyc:1.14.13.45-RXN is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0030339 name: fatty-acyl-ethyl-ester synthase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67] synonym: "FAEE synthase activity" EXACT [EC:3.1.1.67] synonym: "FAEES activity" EXACT [EC:3.1.1.67] synonym: "fatty-acyl ethyl ester synthase " EXACT [GOC:mah] synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" EXACT [EC:3.1.1.67] xref: EC:3.1.1.67 xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0030340 name: hyaluronate lyase activity namespace: molecular_function def: "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1] subset: gosubset_prok synonym: "glucuronoglycosaminoglycan lyase activity" EXACT [EC:4.2.2.1] synonym: "hyaluronidase [but cf. EC 3.2.1.35 (hyalurononglucosaminidase) and EC 3.2.1.36 (hyaluronoglucuronidase)]" RELATED [EC:4.2.2.1] synonym: "hyaluronidase activity" BROAD [EC:4.2.2.1] synonym: "mucinase activity" EXACT [EC:4.2.2.1] synonym: "spreading factor activity" RELATED [EC:4.2.2.1] xref: EC:4.2.2.1 xref: MetaCyc:HYALURONATE-LYASE-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0030341 name: chondroitin AC lyase activity namespace: molecular_function def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5] subset: gosubset_prok synonym: "ChnAC" RELATED [] synonym: "chondroitin AC eliminase activity" EXACT [EC:4.2.2.5] synonym: "chondroitin lyase activity" EXACT [] synonym: "chondroitin sulfate lyase activity" EXACT [EC:4.2.2.5] synonym: "chondroitinase AC" RELATED [] synonym: "chondroitinase activity" BROAD [] xref: EC:4.2.2.5 xref: MetaCyc:4.2.2.5-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0030342 name: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296] synonym: "1,25-(OH)2D3 24-hydroxylase activity" EXACT [PMID:8506296] synonym: "calcitriol 24-hydroxylase activity" EXACT [CHEBI:17823, GOC:mah] xref: Reactome:22681 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity" is_a: GO:0070576 ! vitamin D 24-hydroxylase activity [Term] id: GO:0030343 name: vitamin D3 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O." [ISBN:0471331309 "Biochemical Pathways", MetaCyc:RXN-9829] synonym: "cholecalciferol 25-hydroxylase activity" EXACT [] xref: MetaCyc:RXN-9829 xref: Reactome:22682 "vitamin D3 25-hydroxylase activity" is_a: GO:0070643 ! vitamin D 25-hydroxylase activity [Term] id: GO:0030345 name: structural constituent of tooth enamel namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of tooth enamel." [GOC:mah] is_a: GO:0030021 ! extracellular matrix structural constituent conferring compression resistance [Term] id: GO:0030346 name: protein phosphatase 2B binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 2B." [GOC:jl] synonym: "calcineurin binding" EXACT [] is_a: GO:0019903 ! protein phosphatase binding [Term] id: GO:0030347 name: syntaxin-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-2." [GOC:ai] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0030348 name: syntaxin-3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-3." [GOC:ai] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0030349 name: syntaxin-13 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-13." [GOC:ai] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0030350 name: iron-responsive element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843] synonym: "IRE binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0030351 name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3.- is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0030352 name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3.- is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0030353 name: fibroblast growth factor receptor antagonist activity namespace: molecular_function def: "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah] synonym: "FGF receptor antagonist activity" EXACT [] synonym: "FGFR antagonist activity" EXACT [] is_a: GO:0005104 ! fibroblast growth factor receptor binding is_a: GO:0048019 ! receptor antagonist activity [Term] id: GO:0030354 name: melanin-concentrating hormone activity namespace: molecular_function def: "The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals." [GOC:mah, PMID:11416225, PMID:9792536] is_a: GO:0005179 ! hormone activity [Term] id: GO:0030355 name: small nucleolar ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "snoRNP" EXACT [] is_obsolete: true replaced_by: GO:0005732 [Term] id: GO:0030356 name: small cytoplasmic ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "scRNP" EXACT [] is_obsolete: true replaced_by: GO:0030531 [Term] id: GO:0030359 name: protein phosphatase type 2B regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 2B." [GOC:ai] synonym: "protein phosphatase type 2B, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0030362 name: protein phosphatase type 4 regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 4." [GOC:ai] synonym: "protein phosphatase type 4, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0030363 name: pre-mRNA cleavage factor activity namespace: molecular_function def: "OBSOLETE. Any activity required for the process of mRNA cleavage." [GOC:mah, PMID:10357856] comment: This term was made obsolete because it describes a biological process. is_obsolete: true consider: GO:0006379 [Term] id: GO:0030364 name: cleavage and polyadenylylation specificity factor activity namespace: molecular_function def: "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions." [PMID:10357856] comment: This term was made obsolete because it describes a cellular component. synonym: "cleavage and polyadenylation specificity factor activity" EXACT [] synonym: "cleavage/polyadenylation specificity factor activity" EXACT [] synonym: "CPSF" EXACT [] is_obsolete: true replaced_by: GO:0005847 consider: GO:0006378 consider: GO:0006379 [Term] id: GO:0030365 name: cleavage stimulation factor activity namespace: molecular_function def: "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide." [PMID:10357856] comment: This term was made obsolete because it describes a cellular component. synonym: "CstF" EXACT [] is_obsolete: true replaced_by: GO:0005848 consider: GO:0006379 [Term] id: GO:0030366 name: Mo-molybdopterin synthase activity namespace: molecular_function def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:8514783] synonym: "molybdopterin synthase activity" EXACT [] xref: Reactome:22735 "Mo-molybdopterin synthase activity" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0030367 name: interleukin-17 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-17 receptor." [GOC:ai] synonym: "IL-17" NARROW [] synonym: "interleukin-17 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0030368 name: interleukin-17 receptor activity namespace: molecular_function def: "Combining with interleukin-17 to initiate a change in cell activity." [GOC:jl] synonym: "IL-17 receptor activity" EXACT [GOC:mah] synonym: "IL-17R" EXACT [] xref: Wikipedia:Interleukin-17_receptor is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019975 ! interleukin-17 binding [Term] id: GO:0030369 name: ICAM-3 receptor activity namespace: molecular_function def: "Combining with ICAM-3, intercellular adhesion molecule 3, to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0030370 name: intercellular adhesion molecule-3 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836] synonym: "ICAM-3 receptor binding" EXACT [] synonym: "ICAM-3 receptor ligand" NARROW [] synonym: "intercellular adhesion molecule-3 receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0030371 name: translation repressor activity namespace: molecular_function def: "Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt] is_a: GO:0045182 ! translation regulator activity [Term] id: GO:0030372 name: high molecular weight B cell growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the high molecular weight B cell growth factor receptor." [GOC:ai] synonym: "high molecular weight B cell growth factor receptor ligand" NARROW [] synonym: "high molecular weight B lymphocyte growth factor receptor binding" EXACT [] synonym: "high molecular weight B-cell growth factor receptor binding" EXACT [] synonym: "high molecular weight B-lymphocyte growth factor receptor binding" EXACT [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0030373 name: high molecular weight B cell growth factor receptor activity namespace: molecular_function def: "Combining with a high molecular weight B cell growth factor to initiate a change in cell activity." [GOC:ai] synonym: "high molecular weight B lymphocyte growth factor receptor activity" EXACT [] synonym: "high molecular weight B-cell growth factor receptor activity" EXACT [] synonym: "high molecular weight B-lymphocyte growth factor receptor activity" EXACT [] is_a: GO:0004872 ! receptor activity [Term] id: GO:0030374 name: ligand-dependent nuclear receptor transcription coactivator activity namespace: molecular_function def: "The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT [] is_a: GO:0003713 ! transcription coactivator activity [Term] id: GO:0030375 name: thyroid hormone receptor coactivator activity namespace: molecular_function def: "The function of a transcription cofactor that activates transcription in conjuction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] synonym: "thyroid hormone receptor co-activator activity" EXACT [] is_a: GO:0010861 ! thyroid hormone receptor activator activity is_a: GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity [Term] id: GO:0030377 name: U-plasminogen activator receptor activity namespace: molecular_function def: "Combining with the urokinase plasminogen activator to initiate a change in cell activity." [GOC:mah, PMID:16456079] synonym: "uPAR" EXACT [] synonym: "urokinase plasminogen activator receptor" EXACT [] xref: Wikipedia:Urokinase_receptor is_a: GO:0004872 ! receptor activity [Term] id: GO:0030378 name: serine racemase activity namespace: molecular_function def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd] xref: MetaCyc:5.1.1.18-RXN is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0030379 name: neurotensin receptor activity, non-G-protein coupled namespace: molecular_function def: "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, to initiate a change in cell activity by a mechanism independent of coupling to G proteins." [GOC:mah, PMID:9756851] synonym: "neurotensin receptor activity, non G protein coupled" EXACT [] synonym: "non G protein coupled neurotensin receptor activity" EXACT [] synonym: "non-G-protein coupled neurotensin receptor activity" EXACT [] synonym: "non-G-protein-coupled neurotensin receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0030380 name: interleukin-17E receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-17E receptor." [GOC:ai] synonym: "IL-17E" NARROW [] synonym: "interleukin-17E receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0030381 name: chorion-containing eggshell pattern formation namespace: biological_process def: "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu] is_a: GO:0003002 ! regionalization is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0030382 name: sperm mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] synonym: "sperm mitochondria organisation" EXACT [GOC:curators] synonym: "sperm mitochondria organization and biogenesis" RELATED [GOC:mah] synonym: "sperm mitochondrion organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0030383 name: host-pathogen interaction namespace: biological_process def: "OBSOLETE. Any interaction between a pathogen and its host organism." [GOC:jl] comment: This term was made obsolete because more appropriate terms were created. is_obsolete: true consider: GO:0044403 [Term] id: GO:0030385 name: ferredoxin:thioredoxin reductase activity namespace: molecular_function def: "Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide." [PMID:14769790] is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0030386 name: ferredoxin:thioredoxin reductase complex namespace: cellular_component def: "A protein complex that possesses ferredoxin:thioredoxin reductase activity." [GOC:mah] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin:thioredoxin reductase activity ; GO:0030385'. is_a: GO:0043234 ! protein complex is_a: GO:0044434 ! chloroplast part [Term] id: GO:0030387 name: fructosamine-3-kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase." [PMID:11016445] is_a: GO:0016301 ! kinase activity [Term] id: GO:0030388 name: fructose 1,6-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fructose 1,6-bisphosphate metabolism" EXACT [] is_a: GO:0006000 ! fructose metabolic process [Term] id: GO:0030389 name: fructosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "fructosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process [Term] id: GO:0030391 name: fructosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "fructosamine anabolism" EXACT [] synonym: "fructosamine biosynthesis" EXACT [] synonym: "fructosamine formation" EXACT [] synonym: "fructosamine synthesis" EXACT [] is_a: GO:0030389 ! fructosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0030392 name: fructosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "fructosamine breakdown" EXACT [] synonym: "fructosamine catabolism" EXACT [] synonym: "fructosamine degradation" EXACT [] is_a: GO:0030389 ! fructosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0030393 name: fructoselysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group." [GOC:ai] subset: gosubset_prok synonym: "fructoselysine metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0030389 ! fructosamine metabolic process [Term] id: GO:0030394 name: fructoseglycine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group." [GOC:ai] subset: gosubset_prok synonym: "fructoseglycine metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0030389 ! fructosamine metabolic process [Term] id: GO:0030395 name: lactose binding namespace: molecular_function def: "Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:01928006X] is_a: GO:0048030 ! disaccharide binding [Term] id: GO:0030397 name: membrane disassembly namespace: biological_process def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah] synonym: "membrane breakdown" EXACT [] synonym: "membrane catabolism" EXACT [] synonym: "membrane degradation" EXACT [] is_a: GO:0016044 ! cellular membrane organization is_a: GO:0071845 ! cellular component disassembly at cellular level [Term] id: GO:0030398 name: peroxisomal membrane disassembly namespace: biological_process def: "The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation." [GOC:mah, PMID:11382760] synonym: "peroxisomal membrane breakdown" EXACT [] synonym: "peroxisomal membrane catabolism" EXACT [] synonym: "peroxisomal membrane degradation" EXACT [] is_a: GO:0030397 ! membrane disassembly relationship: part_of GO:0030242 ! peroxisome degradation [Term] id: GO:0030399 name: autophagic membrane disassembly namespace: biological_process def: "The controlled breakdown of the membranes of autophagic vacuoles." [GOC:mah] synonym: "autophagic membrane breakdown" EXACT [] synonym: "autophagic membrane catabolism" EXACT [] synonym: "autophagic membrane degradation" EXACT [] is_a: GO:0030397 ! membrane disassembly relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0030400 name: protease substrate recruitment factor activity namespace: molecular_function def: "OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity." [PMID:11500370] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0030674 [Term] id: GO:0030401 name: transcription antiterminator activity namespace: molecular_function def: "OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok synonym: "transcriptional antiterminator activity" EXACT [] is_obsolete: true consider: GO:0001072 consider: GO:0001073 consider: GO:0006353 [Term] id: GO:0030402 name: matrilysin-2 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 26" EXACT [] synonym: "MMP-26" EXACT [] xref: EC:3.4.24.- is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030403 name: collagenase 4 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 18" EXACT [] synonym: "MMP-18" NARROW [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030404 name: collagenase 3 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 13" EXACT [] synonym: "MMP-13" EXACT [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030405 name: matrix metalloproteinase 19 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "MMP-19" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030406 name: matrix metalloproteinase 25 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "MMP-25" EXACT [] synonym: "MT6-MMP" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030407 name: formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid." [EC:2.1.2.4, EC:2.1.2.5, GOC:mah] subset: gosubset_prok synonym: "formiminotransferase activity" EXACT [] xref: EC:2.1.2.- is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0030408 name: glycine formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine." [EC:2.1.2.4, RHEA:24291] synonym: "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity" EXACT [EC:2.1.2.4] synonym: "FIG formiminotransferase activity" EXACT [EC:2.1.2.4] synonym: "formiminoglycine formiminotransferase activity" EXACT [EC:2.1.2.4] synonym: "glycine formiminotransferase activity" EXACT [] xref: EC:2.1.2.4 xref: KEGG:R02729 xref: MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN xref: RHEA:24291 is_a: GO:0030407 ! formimidoyltransferase activity [Term] id: GO:0030409 name: glutamate formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [EC:2.1.2.5] subset: gosubset_prok synonym: "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity" EXACT [EC:2.1.2.5] synonym: "formiminoglutamic acid transferase activity" EXACT [EC:2.1.2.5] synonym: "formiminoglutamic formiminotransferase activity" EXACT [EC:2.1.2.5] synonym: "glutamate formiminotransferase activity" EXACT [] synonym: "glutamate formyltransferase activity" EXACT [EC:2.1.2.5] xref: EC:2.1.2.5 xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN is_a: GO:0030407 ! formimidoyltransferase activity [Term] id: GO:0030410 name: nicotianamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine." [EC:2.5.1.43, RHEA:16484] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.43] xref: EC:2.5.1.43 xref: KEGG:R00075 xref: MetaCyc:2.5.1.43-RXN xref: RHEA:16484 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0030411 name: scytalone dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O." [EC:4.2.1.94, RHEA:24399] synonym: "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)" EXACT [EC:4.2.1.94] synonym: "scytalone 7,8-hydro-lyase activity" EXACT [EC:4.2.1.94] xref: EC:4.2.1.94 xref: KEGG:R02907 xref: MetaCyc:SCYTALONE-DEHYDRATASE-RXN xref: RHEA:24399 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0030412 name: formimidoyltetrahydrofolate cyclodeaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+)." [EC:4.3.1.4, RHEA:22739] subset: gosubset_prok synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.4] synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)" EXACT [EC:4.3.1.4] synonym: "formiminotetrahydrofolate cyclodeaminase activity" EXACT [EC:4.3.1.4] xref: EC:4.3.1.4 xref: KEGG:R02302 xref: MetaCyc:4.3.1.4-RXN xref: Reactome:23291 "formimidoyltetrahydrofolate cyclodeaminase activity" xref: RHEA:22739 is_a: GO:0016841 ! ammonia-lyase activity is_a: GO:0019239 ! deaminase activity [Term] id: GO:0030413 name: competence pheromone activity namespace: molecular_function def: "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645] subset: gosubset_prok is_a: GO:0005186 ! pheromone activity [Term] id: GO:0030414 name: peptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] subset: gosubset_prok synonym: "protease inhibitor activity" RELATED [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0061134 ! peptidase regulator activity [Term] id: GO:0030415 name: carboxypeptidase A inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. is_obsolete: true replaced_by: GO:0030414 [Term] id: GO:0030416 name: methylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylamine (CH3NH2), a flammable, explosive gas, used in tanning and in organic synthesis and produced naturally in some decaying fish, certain plants, and crude methanol." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "methylamine metabolism" EXACT [] synonym: "methylammonium metabolic process" EXACT [] synonym: "methylammonium metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0030417 name: nicotianamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] subset: gosubset_prok synonym: "nicotianamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] id: GO:0030418 name: nicotianamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] subset: gosubset_prok synonym: "nicotianamine anabolism" EXACT [] synonym: "nicotianamine biosynthesis" EXACT [] synonym: "nicotianamine formation" EXACT [] synonym: "nicotianamine synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030417 ! nicotianamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process [Term] id: GO:0030419 name: nicotianamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] subset: gosubset_prok synonym: "nicotianamine breakdown" EXACT [] synonym: "nicotianamine catabolism" EXACT [] synonym: "nicotianamine degradation" EXACT [] is_a: GO:0030417 ! nicotianamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process [Term] id: GO:0030420 name: establishment of competence for transformation namespace: biological_process def: "The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation." [GOC:mah, ISBN:1555811027] subset: gosubset_prok is_a: GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0009294 ! DNA mediated transformation [Term] id: GO:0030421 name: defecation namespace: biological_process def: "The expulsion of feces from the rectum." [GOC:mah] xref: Wikipedia:Defecation is_a: GO:0007588 ! excretion [Term] id: GO:0030422 name: production of siRNA involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] synonym: "production of guide RNAs involved in RNA interference" EXACT [GOC:mah] synonym: "RNA interference, production of guide RNAs" EXACT [] synonym: "RNA interference, production of siRNA" EXACT [GOC:mah] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0030423 name: targeting of mRNA for destruction involved in RNA interference namespace: biological_process def: "The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674] synonym: "RNA interference, targeting of mRNA for destruction" EXACT [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0030424 name: axon namespace: cellular_component def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: NIF_Subcellular:sao1770195789 xref: Wikipedia:Axon is_a: GO:0043005 ! neuron projection [Term] id: GO:0030425 name: dendrite namespace: cellular_component def: "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: NIF_Subcellular:sao1211023249 xref: Wikipedia:Dendrite is_a: GO:0043005 ! neuron projection [Term] id: GO:0030426 name: growth cone namespace: cellular_component def: "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] xref: Wikipedia:Growth_cone is_a: GO:0030427 ! site of polarized growth is_a: GO:0044463 ! cell projection part relationship: part_of GO:0043005 ! neuron projection [Term] id: GO:0030427 name: site of polarized growth namespace: cellular_component alt_id: GO:0000134 alt_id: GO:0030483 def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah] subset: goslim_candida subset: goslim_pir subset: goslim_yeast is_a: GO:0044464 ! cell part [Term] id: GO:0030428 name: cell septum namespace: cellular_component def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526] subset: goslim_pir subset: gosubset_prok synonym: "cross wall" EXACT [] synonym: "septum" BROAD [] is_a: GO:0044464 ! cell part [Term] id: GO:0030429 name: kynureninase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [EC:3.7.1.3] subset: gosubset_prok synonym: "kynurenine hydrolase activity" EXACT [EC:3.7.1.3] synonym: "L-kynurenine hydrolase activity" EXACT [EC:3.7.1.3] synonym: "l-kynurenine hydrolase activity" EXACT [EC:3.7.1.3] xref: EC:3.7.1.3 xref: MetaCyc:KYNURENINASE-RXN xref: Reactome:23316 "kynureninase activity" is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0030430 name: host cell cytoplasm namespace: cellular_component def: "The cytoplasm of a host cell." [GOC:mah] subset: gosubset_prok is_a: GO:0033646 ! host intracellular part [Term] id: GO:0030431 name: sleep namespace: biological_process def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] subset: goslim_pir synonym: "diapause" RELATED [] synonym: "dormancy" RELATED [] synonym: "lethargus" RELATED [] xref: Wikipedia:Sleep is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030432 name: peristalsis namespace: biological_process def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Peristalsis is_a: GO:0014821 ! phasic smooth muscle contraction [Term] id: GO:0030433 name: ER-associated protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858] comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. synonym: "endoplasmic reticulum-associated protein catabolic process" EXACT [] synonym: "endoplasmic reticulum-associated protein catabolism" EXACT [] synonym: "ER-associated protein breakdown" EXACT [] synonym: "ER-associated protein catabolism" EXACT [] synonym: "ER-associated protein degradation" EXACT [] synonym: "ERAD" EXACT [] is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0030435 name: sporulation resulting in formation of a cellular spore namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913] comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. subset: goslim_yeast subset: gosubset_prok synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb] synonym: "spore biosynthesis" EXACT [] synonym: "spore differentiation" EXACT [] synonym: "spore formation" EXACT [] xref: Wikipedia:Sporogenesis is_a: GO:0030154 ! cell differentiation is_a: GO:0043934 ! sporulation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0030436 name: asexual sporulation namespace: biological_process def: "The formation of spores derived from the products of mitosis. Examples of this process are found in Bacterial species." [GOC:mah, PMID:9529886] subset: gosubset_prok synonym: "asexual spore formation" EXACT [] synonym: "mitotic spore formation" EXACT [] synonym: "mitotic sporulation" EXACT [] is_a: GO:0019954 ! asexual reproduction is_a: GO:0043934 ! sporulation [Term] id: GO:0030437 name: ascospore formation namespace: biological_process alt_id: GO:0007151 def: "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:mah, PMID:16339736] subset: goslim_pombe synonym: "ascospore biosynthesis" EXACT [] synonym: "spore formation" BROAD [] synonym: "sporulation" BROAD [] is_a: GO:0022413 ! reproductive process in single-celled organism is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development [Term] id: GO:0030438 name: MAPKKK cascade during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0030439 name: activation of MAPK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0030440 name: activation of MAPKK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0030441 name: activation of MAPKKK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0030442 name: inactivation of MAPK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0030443 name: nuclear translocation of MAPK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0030444 name: microtubule depolymerization during nuclear congression namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because the entire branch of the ontology was changed. is_obsolete: true replaced_by: GO:0007019 [Term] id: GO:0030445 name: yeast-form cell wall namespace: cellular_component def: "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc] comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'. is_a: GO:0009277 ! fungal-type cell wall [Term] id: GO:0030446 name: hyphal cell wall namespace: cellular_component def: "The cell wall surrounding a fungal hypha." [GOC:mah] comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'. is_a: GO:0009277 ! fungal-type cell wall [Term] id: GO:0030447 name: filamentous growth namespace: biological_process def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141] subset: goslim_candida is_a: GO:0040007 ! growth [Term] id: GO:0030448 name: hyphal growth namespace: biological_process def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295] subset: goslim_candida is_a: GO:0030447 ! filamentous growth [Term] id: GO:0030449 name: regulation of complement activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of complement activation." [GOC:go_curators] synonym: "regulation of complement cascade" EXACT [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage is_a: GO:2000257 ! regulation of protein activation cascade relationship: regulates GO:0006956 ! complement activation [Term] id: GO:0030450 name: regulation of complement activation, classical pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation." [GOC:go_curators] synonym: "regulation of complement cascade, classical pathway" EXACT [GOC:add] is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin is_a: GO:0030449 ! regulation of complement activation relationship: regulates GO:0006958 ! complement activation, classical pathway [Term] id: GO:0030451 name: regulation of complement activation, alternative pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation." [GOC:go_curators] synonym: "regulation of complement cascade, alternative pathway" EXACT [GOC:add] is_a: GO:0030449 ! regulation of complement activation is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0006957 ! complement activation, alternative pathway [Term] id: GO:0030455 name: MAPKKK cascade (mating sensu Fungi) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus." [GOC:mah] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030456 name: activation of MAPK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030457 name: activation of MAPKK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030458 name: activation of MAPKKK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030459 name: inactivation of MAPK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030460 name: nuclear translocation of MAPK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030463 name: cell aging (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. is_obsolete: true replaced_by: GO:0007569 [Term] id: GO:0030464 name: aging dependent sterility (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators] comment: This term was made obsolete because it reflected a trait or phenotype. is_obsolete: true consider: GO:0030466 [Term] id: GO:0030465 name: autophagic death (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because a more correct term has been created. is_obsolete: true consider: GO:0048102 [Term] id: GO:0030466 name: chromatin silencing at silent mating-type cassette namespace: biological_process alt_id: GO:0006347 def: "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin." [GOC:mcc] synonym: "aging-dependent sterility" NARROW [] synonym: "chromatin silencing at HML and HMR" NARROW [] synonym: "heterochromatic silencing at silent mating-type cassette" EXACT [] synonym: "silent mating-type cassette chromatin silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0030470 name: spore germination (sensu Fungi) namespace: biological_process alt_id: GO:0007153 def: "OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mcc] comment: This term was made obsolete because a sensu term was not needed. synonym: "germination (sensu Saccharomyces)" NARROW [] is_obsolete: true replaced_by: GO:0009847 [Term] id: GO:0030471 name: spindle pole body and microtubule cycle (sensu Fungi) namespace: biological_process alt_id: GO:0007102 def: "OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649] comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. synonym: "spindle pole body and microtubule cycle (sensu Saccharomyces)" NARROW [] is_obsolete: true consider: GO:0007051 consider: GO:0051300 [Term] id: GO:0030472 name: mitotic spindle organization in nucleus namespace: biological_process alt_id: GO:0000071 def: "A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level." [GOC:mah] synonym: "mitotic spindle assembly" BROAD [] synonym: "mitotic spindle organisation in nucleus" EXACT [] synonym: "mitotic spindle organization and biogenesis in cell nucleus" EXACT [] synonym: "mitotic spindle organization and biogenesis in nucleus" EXACT [] synonym: "spindle organization and biogenesis in nucleus during mitosis" EXACT [] is_a: GO:0007052 ! mitotic spindle organization [Term] id: GO:0030473 name: nuclear migration along microtubule namespace: biological_process alt_id: GO:0000065 def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT [] synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT [] synonym: "microtubule-dependent nuclear positioning" EXACT [] synonym: "microtubule-dependent nucleus positioning" EXACT [] synonym: "microtubule-mediated nuclear migration" EXACT [] synonym: "nuclear migration, microtubule-mediated" EXACT [] synonym: "nuclear movement, microtubule-mediated" BROAD [] synonym: "nucleus migration" BROAD [] synonym: "transport of nucleus by microtubules" EXACT [] synonym: "transport of nucleus, microtubule-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0030474 name: spindle pole body duplication namespace: biological_process def: "Construction of a new spindle pole body." [GOC:clt] synonym: "spindle pole body assembly" EXACT [] synonym: "spindle pole body biogenesis" EXACT [] synonym: "spindle pole body biosynthesis" EXACT [] synonym: "spindle pole body formation" EXACT [] synonym: "spindle pole body replication" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0051300 ! spindle pole body organization [Term] id: GO:0030476 name: ascospore wall assembly namespace: biological_process alt_id: GO:0007152 def: "The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:14702385] synonym: "spore wall assembly" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0042244 ! spore wall assembly is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0071940 ! fungal-type cell wall assembly relationship: part_of GO:0070591 ! ascospore wall biogenesis [Term] id: GO:0030478 name: actin cap namespace: cellular_component alt_id: GO:0000143 def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae." [GOC:mah, ISBN:10652251] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0030479 name: actin cortical patch namespace: cellular_component alt_id: GO:0005857 def: "A discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963] synonym: "actin patch" EXACT [] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0030484 name: muscle fiber namespace: cellular_component def: "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194] comment: This term was made obsolete because a muscle fiber is a cell type rather than a cell component. To update annotations, consider the external ontology term 'muscle cell ; CL:0000187'. synonym: "muscle fibre" EXACT [] is_obsolete: true consider: GO:0043292 [Term] id: GO:0030485 name: smooth muscle contractile fiber namespace: cellular_component def: "The contractile fiber of smooth muscle cells." [GOC:mah] synonym: "smooth muscle fiber" BROAD [] synonym: "smooth muscle fibre" EXACT [] is_a: GO:0043292 ! contractile fiber is_a: GO:0044449 ! contractile fiber part [Term] id: GO:0030486 name: smooth muscle dense body namespace: cellular_component def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194] is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030485 ! smooth muscle contractile fiber [Term] id: GO:0030487 name: inositol-4,5-bisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the removal of a phosphate group from the carbon-5 position of D-myo-inositol 4,5-bisphosphate." [GOC:mah] is_a: GO:0016312 ! inositol bisphosphate phosphatase activity [Term] id: GO:0030488 name: tRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah] subset: gosubset_prok is_a: GO:0001510 ! RNA methylation is_a: GO:0006400 ! tRNA modification [Term] id: GO:0030489 name: processing of 27S pre-rRNA namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators] comment: This term was made obsolete because it was not defined and did not correspond to the production of a single specific mature rRNA product. is_obsolete: true [Term] id: GO:0030490 name: maturation of SSU-rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators] synonym: "processing of 20S pre-rRNA" NARROW [] synonym: "SSU-rRNA maturation" EXACT [GOC:dph, GOC:tb] is_a: GO:0006364 ! rRNA processing relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis [Term] id: GO:0030491 name: heteroduplex formation namespace: biological_process def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:10357855] xref: Reactome:76007 "Heteroduplex formation" xref: Reactome:76008 "Synaptic stable pairing/D-loop structure formation between recombining DNA molecules" is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0030492 name: hemoglobin binding namespace: molecular_function def: "Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [CHEBI:35143, GOC:jl] synonym: "globin binding" NARROW [] synonym: "haemoglobin binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0030493 name: bacteriochlorophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "bacteriochlorophyll metabolism" EXACT [] is_a: GO:0015994 ! chlorophyll metabolic process [Term] id: GO:0030494 name: bacteriochlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "bacteriochlorophyll anabolism" EXACT [] synonym: "bacteriochlorophyll biosynthesis" EXACT [] synonym: "bacteriochlorophyll formation" EXACT [] synonym: "bacteriochlorophyll synthesis" EXACT [] is_a: GO:0015995 ! chlorophyll biosynthetic process is_a: GO:0030493 ! bacteriochlorophyll metabolic process [Term] id: GO:0030495 name: bacteriochlorophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:go_curators] subset: gosubset_prok synonym: "bacteriochlorophyll breakdown" EXACT [] synonym: "bacteriochlorophyll catabolism" EXACT [] synonym: "bacteriochlorophyll degradation" EXACT [] is_a: GO:0015996 ! chlorophyll catabolic process is_a: GO:0030493 ! bacteriochlorophyll metabolic process [Term] id: GO:0030496 name: midbody namespace: cellular_component def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] subset: goslim_pir xref: Wikipedia:Midbody_(cell_biology) is_a: GO:0044464 ! cell part [Term] id: GO:0030497 name: fatty acid elongation namespace: biological_process def: "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094] subset: gosubset_prok is_a: GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0030500 name: regulation of bone mineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators] is_a: GO:0030278 ! regulation of ossification is_a: GO:0070167 ! regulation of biomineral tissue development relationship: regulates GO:0030282 ! bone mineralization [Term] id: GO:0030501 name: positive regulation of bone mineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators] synonym: "activation of bone mineralization" NARROW [] synonym: "stimulation of bone mineralization" NARROW [] synonym: "up regulation of bone mineralization" EXACT [] synonym: "up-regulation of bone mineralization" EXACT [] synonym: "upregulation of bone mineralization" EXACT [] is_a: GO:0030500 ! regulation of bone mineralization is_a: GO:0045778 ! positive regulation of ossification is_a: GO:0070169 ! positive regulation of biomineral tissue development relationship: positively_regulates GO:0030282 ! bone mineralization [Term] id: GO:0030502 name: negative regulation of bone mineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators] synonym: "down regulation of bone mineralization" EXACT [] synonym: "down-regulation of bone mineralization" EXACT [] synonym: "downregulation of bone mineralization" EXACT [] synonym: "inhibition of bone mineralization" NARROW [] is_a: GO:0030279 ! negative regulation of ossification is_a: GO:0030500 ! regulation of bone mineralization is_a: GO:0070168 ! negative regulation of biomineral tissue development relationship: negatively_regulates GO:0030282 ! bone mineralization [Term] id: GO:0030504 name: inorganic diphosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of inorganic diphosphate across a membrane." [PMID:11326272] synonym: "inorganic pyrophosphate transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0030505 name: inorganic diphosphate transport namespace: biological_process def: "The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "inorganic pyrophosphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0030506 name: ankyrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0030507 name: spectrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0030508 name: thiol-disulfide exchange intermediate activity namespace: molecular_function def: "OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah] comment: This term was made obsolete because it represents a combination of gene product features and involvement in a biological process. subset: gosubset_prok synonym: "glutaredoxin" NARROW [] synonym: "thiol-disulphide exchange intermediate activity" EXACT [] synonym: "thioredoxin" NARROW [] is_obsolete: true consider: GO:0006467 consider: GO:0015036 [Term] id: GO:0030509 name: BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor." [ISBN:0878932437] synonym: "BMP receptor signaling pathway" RELATED [] synonym: "BMP signalling pathway" EXACT [] synonym: "bone morphogenetic protein signaling pathway" EXACT [] synonym: "bone morphogenetic protein signalling pathway" EXACT [] xref: Reactome:1253535 "Signaling by BMP" xref: Reactome:1280474 "Signaling by BMP" xref: Reactome:1299297 "Signaling by BMP" xref: Reactome:1327052 "Signaling by BMP" xref: Reactome:1353146 "Signaling by BMP" xref: Reactome:1373325 "Signaling by BMP" xref: Reactome:1393349 "Signaling by BMP" xref: Reactome:1417843 "Signaling by BMP" xref: Reactome:1450934 "Signaling by BMP" xref: Reactome:1471321 "Signaling by BMP" xref: Reactome:1483295 "Signaling by BMP" xref: Reactome:201451 "Signaling by BMP" is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0030510 name: regulation of BMP signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah] synonym: "regulation of BMP receptor signaling pathway" RELATED [] synonym: "regulation of BMP signalling pathway" EXACT [] synonym: "regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "regulation of bone morphogenetic protein signalling pathway" EXACT [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0030509 ! BMP signaling pathway [Term] id: GO:0030511 name: positive regulation of transforming growth factor beta receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of transforming growth factor beta receptor signaling pathway" NARROW [] synonym: "positive regulation of TGF-beta receptor signaling pathway" EXACT [] synonym: "positive regulation of TGFbeta receptor signaling pathway" EXACT [] synonym: "positive regulation of transforming growth factor beta receptor signalling pathway" EXACT [] synonym: "stimulation of transforming growth factor beta receptor signaling pathway" NARROW [] synonym: "up regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "up-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "upregulation of transforming growth factor beta receptor signaling pathway" EXACT [] is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0030512 name: negative regulation of transforming growth factor beta receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah] synonym: "down regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "down-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "downregulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "inhibition of transforming growth factor beta receptor signaling pathway" NARROW [] synonym: "negative regulation of TGF-beta receptor signaling pathway" EXACT [] synonym: "negative regulation of TGFbeta receptor signaling pathway" EXACT [] synonym: "negative regulation of transforming growth factor beta receptor signalling pathway" EXACT [] xref: Reactome:1235183 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling" xref: Reactome:1235193 "I-SMAD competes with R-SMAD for type I receptor" xref: Reactome:1262546 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling" xref: Reactome:1262556 "I-SMAD competes with R-SMAD for type I receptor" xref: Reactome:1287322 "I-SMAD competes with R-SMAD for type I receptor" xref: Reactome:1308811 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling" xref: Reactome:1308821 "I-SMAD competes with R-SMAD for type I receptor" xref: Reactome:1335643 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling" xref: Reactome:1335653 "I-SMAD competes with R-SMAD for type I receptor" xref: Reactome:1401789 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling" xref: Reactome:1401802 "I-SMAD competes with R-SMAD for type I receptor" xref: Reactome:1429800 "I-SMAD competes with R-SMAD for type I receptor" xref: Reactome:1458619 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling" xref: Reactome:173481 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling" xref: Reactome:173512 "I-SMAD competes with R-SMAD for type I receptor" is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0030513 name: positive regulation of BMP signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] synonym: "activation of BMP signaling pathway" NARROW [] synonym: "positive regulation of BMP receptor signaling pathway" RELATED [] synonym: "positive regulation of BMP signalling pathway" EXACT [] synonym: "positive regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "positive regulation of bone morphogenetic protein signalling pathway" EXACT [] synonym: "stimulation of BMP signaling pathway" NARROW [] synonym: "up regulation of BMP signaling pathway" EXACT [] synonym: "up-regulation of BMP signaling pathway" EXACT [] synonym: "upregulation of BMP signaling pathway" EXACT [] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0030509 ! BMP signaling pathway [Term] id: GO:0030514 name: negative regulation of BMP signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] synonym: "down regulation of BMP signaling pathway" EXACT [] synonym: "down-regulation of BMP signaling pathway" EXACT [] synonym: "downregulation of BMP signaling pathway" EXACT [] synonym: "inhibition of BMP signaling pathway" NARROW [] synonym: "negative regulation of BMP receptor signaling pathway" RELATED [] synonym: "negative regulation of BMP signalling pathway" EXACT [] synonym: "negative regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "negative regulation of bone morphogenetic protein signalling pathway" EXACT [] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0030509 ! BMP signaling pathway [Term] id: GO:0030515 name: snoRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with small nucleolar RNA." [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0030516 name: regulation of axon extension namespace: biological_process def: "Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0050770 ! regulation of axonogenesis relationship: regulates GO:0048675 ! axon extension [Term] id: GO:0030517 name: negative regulation of axon extension namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah] synonym: "down regulation of axon extension" EXACT [] synonym: "down-regulation of axon extension" EXACT [] synonym: "downregulation of axon extension" EXACT [] synonym: "inhibition of axon extension" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0050771 ! negative regulation of axonogenesis relationship: negatively_regulates GO:0048675 ! axon extension [Term] id: GO:0030518 name: steroid hormone receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a steroid hormone receptor binding to one of its physiological ligands." [GOC:mah, GOC:signaling] synonym: "steroid hormone receptor signalling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0030519 name: snoRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a small nucleolar ribonucleoprotein particle." [GOC:mah] is_a: GO:0043021 ! ribonucleoprotein binding [Term] id: GO:0030520 name: estrogen receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an estrogen binding to its receptor." [GOC:mah] synonym: "estrogen receptor signalling pathway" EXACT [] is_a: GO:0030518 ! steroid hormone receptor signaling pathway [Term] id: GO:0030521 name: androgen receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GOC:mah] synonym: "androgen receptor signalling pathway" EXACT [] is_a: GO:0030518 ! steroid hormone receptor signaling pathway [Term] id: GO:0030522 name: intracellular receptor mediated signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] synonym: "intracellular receptor-mediated signaling pathway" EXACT [] synonym: "intracellular receptor-mediated signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0030523 name: dihydrolipoamide S-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide." [EC:2.3.1.12, GOC:mah] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0016417 ! S-acyltransferase activity [Term] id: GO:0030526 name: granulocyte macrophage colony-stimulating factor receptor complex namespace: cellular_component def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah] synonym: "granulocyte macrophage colony stimulating factor receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0030527 name: structural constituent of chromatin namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0030528 name: transcription regulator activity namespace: molecular_function def: "OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "transcriptional regulator activity" EXACT [] is_obsolete: true consider: GO:0000988 consider: GO:0001071 consider: GO:0006351 [Term] id: GO:0030529 name: ribonucleoprotein complex namespace: cellular_component def: "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] subset: goslim_pir subset: gosubset_prok synonym: "protein-RNA complex" EXACT [] synonym: "ribonucleoprotein" EXACT [] synonym: "RNA-protein complex" EXACT [] synonym: "RNP" EXACT [] xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! macromolecular complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030530 name: heterogeneous nuclear ribonucleoprotein complex namespace: cellular_component def: "Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "heterogeneous nuclear ribonucleoprotein" EXACT [] synonym: "hnRNP" EXACT [] xref: Wikipedia:Heterogeneous_ribonucleoprotein_particle is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0030531 name: small cytoplasmic ribonucleoprotein complex namespace: cellular_component def: "A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah] synonym: "scRNP" EXACT [] synonym: "small cytoplasmic ribonucleoprotein" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0030532 name: small nuclear ribonucleoprotein complex namespace: cellular_component def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] subset: goslim_pir synonym: "small nuclear ribonucleoprotein" EXACT [] synonym: "snRNP" EXACT [] xref: Wikipedia:SnRNP is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0030533 name: triplet codon-amino acid adaptor activity namespace: molecular_function def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. subset: goslim_candida subset: goslim_yeast synonym: "transfer RNA" RELATED [] synonym: "tRNA" RELATED [] is_a: GO:0000499 ! base pairing with mRNA is_a: GO:0060090 ! binding, bridging [Term] id: GO:0030534 name: adult behavior namespace: biological_process def: "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "adult behavioral response to stimulus" EXACT [] synonym: "adult behaviour" EXACT [] synonym: "adult behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030535 name: adult feeding behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. is_obsolete: true replaced_by: GO:0008343 [Term] id: GO:0030536 name: larval feeding behavior namespace: biological_process def: "Feeding behavior in a larval (immature) organism." [GOC:mah] comment: See also the biological process term 'feeding behavior ; GO:0007631'. synonym: "larval feeding behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0030537 ! larval behavior [Term] id: GO:0030537 name: larval behavior namespace: biological_process alt_id: GO:0017037 def: "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "larval behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030538 name: embryonic genitalia morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf] synonym: "embryonic genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis is_a: GO:0048562 ! embryonic organ morphogenesis [Term] id: GO:0030539 name: male genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888] synonym: "male genital development" EXACT [] is_a: GO:0048806 ! genitalia development relationship: part_of GO:0046546 ! development of primary male sexual characteristics [Term] id: GO:0030540 name: female genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah] synonym: "female genital development" EXACT [] is_a: GO:0048806 ! genitalia development relationship: part_of GO:0046545 ! development of primary female sexual characteristics [Term] id: GO:0030541 name: plasmid partitioning namespace: biological_process alt_id: GO:0030542 def: "Any process in which plasmids are segregated or distributed into daughter cells upon cell division." [GOC:mah] subset: gosubset_prok is_a: GO:0006276 ! plasmid maintenance [Term] id: GO:0030543 name: 2-micrometer plasmid partitioning namespace: biological_process def: "The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division." [GOC:mah] is_a: GO:0030541 ! plasmid partitioning [Term] id: GO:0030544 name: Hsp70 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0031072 ! heat shock protein binding [Term] id: GO:0030545 name: receptor regulator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed." [GOC:ceb] is_a: GO:0003674 ! molecular_function [Term] id: GO:0030546 name: receptor activator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb] is_a: GO:0030545 ! receptor regulator activity [Term] id: GO:0030547 name: receptor inhibitor activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased." [GOC:ceb] is_a: GO:0030545 ! receptor regulator activity [Term] id: GO:0030548 name: acetylcholine receptor regulator activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah] is_a: GO:0030545 ! receptor regulator activity [Term] id: GO:0030549 name: acetylcholine receptor activator activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah] is_a: GO:0030546 ! receptor activator activity is_a: GO:0030548 ! acetylcholine receptor regulator activity [Term] id: GO:0030550 name: acetylcholine receptor inhibitor activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased." [GOC:mah] is_a: GO:0030547 ! receptor inhibitor activity is_a: GO:0030548 ! acetylcholine receptor regulator activity [Term] id: GO:0030551 name: cyclic nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai] subset: gosubset_prok is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0030552 name: cAMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai] subset: gosubset_prok synonym: "3',5' cAMP binding" EXACT [] synonym: "3',5'-cAMP binding" EXACT [] synonym: "adenosine 3',5'-cyclophosphate binding" EXACT [] synonym: "cyclic AMP binding" EXACT [] is_a: GO:0016208 ! AMP binding is_a: GO:0030551 ! cyclic nucleotide binding [Term] id: GO:0030553 name: cGMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai] synonym: "3',5' cGMP binding" EXACT [] synonym: "3',5'-cGMP binding" EXACT [] synonym: "cyclic GMP binding" EXACT [] is_a: GO:0019002 ! GMP binding is_a: GO:0030551 ! cyclic nucleotide binding [Term] id: GO:0030554 name: adenyl nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0017076 ! purine nucleotide binding [Term] id: GO:0030555 name: RNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0000498 ! base pairing with RNA [Term] id: GO:0030556 name: rRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0000944 ! base pairing with rRNA is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030557 name: tRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0000946 ! base pairing with tRNA is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030558 name: RNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030559 name: rRNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030556 ! rRNA modification guide activity is_a: GO:0030558 ! RNA pseudouridylation guide activity [Term] id: GO:0030560 name: tRNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030557 ! tRNA modification guide activity is_a: GO:0030558 ! RNA pseudouridylation guide activity [Term] id: GO:0030561 name: RNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030562 name: rRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030556 ! rRNA modification guide activity is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity [Term] id: GO:0030563 name: snRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity is_a: GO:0030566 ! snRNA modification guide activity [Term] id: GO:0030564 name: tRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030557 ! tRNA modification guide activity is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity [Term] id: GO:0030565 name: snRNA pseudouridylation guide activity namespace: molecular_function def: "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. is_a: GO:0030558 ! RNA pseudouridylation guide activity is_a: GO:0030566 ! snRNA modification guide activity [Term] id: GO:0030566 name: snRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0000945 ! base pairing with snRNA is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030567 name: thrombin activator activity namespace: molecular_function def: "OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin." [GOC:mah] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. subset: gosubset_prok synonym: "prothrombin activator activity" RELATED [GOC:dph, GOC:tb] is_obsolete: true replaced_by: GO:0016504 [Term] id: GO:0030568 name: plasmin inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin." [GOC:mah] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. is_obsolete: true replaced_by: GO:0004867 [Term] id: GO:0030569 name: chymotrypsin inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function term. is_obsolete: true replaced_by: GO:0004867 [Term] id: GO:0030570 name: pectate lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2] subset: gosubset_prok synonym: "(1->4)-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.2] synonym: "alpha-1,4-D-endopolygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "endo-alpha-1,4-polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "endogalacturonate transeliminase activity" EXACT [EC:4.2.2.2] synonym: "endopectin methyltranseliminase activity" EXACT [EC:4.2.2.2] synonym: "pectate transeliminase activity" EXACT [EC:4.2.2.2] synonym: "pectic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "pectic acid transeliminase activity" EXACT [EC:4.2.2.2] synonym: "pectic lyase activity" BROAD [EC:4.2.2.2] synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.2] synonym: "PGA lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonate lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic acid trans-eliminase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic transeliminase activity" EXACT [EC:4.2.2.2] synonym: "PPase-N activity" EXACT [EC:4.2.2.2] xref: EC:4.2.2.2 xref: MetaCyc:4.2.2.2-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0030572 name: phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group." [GOC:mb] subset: gosubset_prok is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0030573 name: bile acid catabolic process namespace: biological_process alt_id: GO:0019613 def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW [] synonym: "bile acid breakdown" EXACT [] synonym: "bile acid catabolism" EXACT [] synonym: "bile acid degradation" EXACT [] synonym: "cholate catabolic process" NARROW [] xref: MetaCyc:7ALPHADEHYDROX-PWY is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0030574 name: collagen catabolic process namespace: biological_process def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194] synonym: "collagen breakdown" EXACT [] synonym: "collagen catabolism" EXACT [] synonym: "collagen degradation" EXACT [] is_a: GO:0032963 ! collagen metabolic process is_a: GO:0044243 ! multicellular organismal catabolic process [Term] id: GO:0030575 name: nuclear body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:dph, GOC:jl, GOC:mah] synonym: "nuclear body organisation" EXACT [GOC:curators] synonym: "nuclear body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0030576 name: Cajal body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] comment: See also the cellular component term 'Cajal body ; GO:0015030'. synonym: "Cajal body organisation" EXACT [GOC:curators] synonym: "Cajal body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0030577 name: Lands organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies." [GOC:mah, PMID:10921892, PMID:8695863] comment: See also the cellular component term 'Lands ; GO:0016606'. synonym: "Lands organisation" EXACT [GOC:curators] synonym: "Lands organization and biogenesis" RELATED [GOC:mah] synonym: "LYSP100-associated nuclear domain organization" EXACT [GOC:mah] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0030578 name: PML body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia)." [GOC:mah, PMID:10806078] comment: See also the cellular component term 'PML body ; GO:0016605'. synonym: "PML body organisation" EXACT [GOC:curators] synonym: "PML body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0030579 name: ubiquitin-dependent SMAD protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GOC:go_curators] synonym: "ubiquitin-dependent SMAD protein breakdown" EXACT [] synonym: "ubiquitin-dependent SMAD protein catabolism" EXACT [] synonym: "ubiquitin-dependent SMAD protein degradation" EXACT [] is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0030580 name: quinone cofactor methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb] subset: gosubset_prok is_a: GO:0008169 ! C-methyltransferase activity [Term] id: GO:0030581 name: symbiont intracellular protein transport in host namespace: biological_process def: "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] synonym: "host cell protein transport" EXACT [] synonym: "intracellular protein transport in host" EXACT [] is_a: GO:0051701 ! interaction with host is_a: GO:0051708 ! intracellular protein transport in other organism involved in symbiotic interaction [Term] id: GO:0030582 name: fruiting body development namespace: biological_process def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. A fruiting body is a multicellular structure that contains spores." [GOC:mah, GOC:mtg_sensu] synonym: "fruiting body formation" EXACT [] is_a: GO:0075259 ! spore-bearing organ development [Term] id: GO:0030583 name: fruiting body development in cellular response to starvation namespace: biological_process def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. The process begins when cells respond to a lack of nutrients in the environment and ends when the fruiting body is a mature structure." [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786] comment: For example, as seen in myxobacterium and Dictyostelium. subset: gosubset_prok is_a: GO:0009267 ! cellular response to starvation is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0048869 ! cellular developmental process is_a: GO:0055084 ! fruiting body development in response to starvation [Term] id: GO:0030584 name: sporocarp development namespace: biological_process def: "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea." [GOC:mah, GOC:mtg_sensu] synonym: "fruiting body development" BROAD [] is_a: GO:0030582 ! fruiting body development [Term] id: GO:0030585 name: phosphoenolpyruvate carboxykinase (diphosphate) activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate." [EC:4.1.1.38, RHEA:22359] synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.38] synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.38] synonym: "PEP carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] synonym: "PEPCTrP" RELATED [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxykinase (pyrophosphate) activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.38] synonym: "phosphopyruvate carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphopyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] xref: EC:4.1.1.38 xref: KEGG:R00346 xref: MetaCyc:4.1.1.38-RXN xref: RHEA:22359 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0030586 name: [methionine synthase] reductase activity namespace: molecular_function def: "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8] comment: Note that this was EC:2.1.1.135. synonym: "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED [] synonym: "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT [] synonym: "methionine synthase cob(II)alamin reductase (methylating) activity" EXACT [EC:1.16.1.8] synonym: "methionine synthase reductase activity" EXACT [EC:1.16.1.8] synonym: "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" EXACT [EC:1.16.1.8] synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.8] xref: EC:1.16.1.8 xref: MetaCyc:2.1.1.135-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0030587 name: sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:2530 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "fruiting body development" BROAD [] synonym: "fruiting body formation" BROAD [] synonym: "sorocarp biosynthesis" EXACT [] synonym: "sorocarp formation" EXACT [] is_a: GO:0055084 ! fruiting body development in response to starvation relationship: part_of GO:0019954 ! asexual reproduction [Term] id: GO:0030588 name: pseudocleavage namespace: biological_process def: "Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis." [GOC:mah, PMID:10751167, PMID:7729583] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0030589 name: pseudocleavage involved in syncytial blastoderm formation namespace: biological_process def: "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] synonym: "pseudocleavage during syncytial blastoderm formation" RELATED [GOC:dph] is_a: GO:0030588 ! pseudocleavage relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0030590 name: first cell cycle pseudocleavage namespace: biological_process def: "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms." [GOC:mtg_sensu, PMID:7729583] is_a: GO:0030588 ! pseudocleavage [Term] id: GO:0030591 name: NAD DNA ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0030592 name: DNA ADP-ribosylation namespace: biological_process def: "The covalent attachment of an ADP-ribosyl group to the amino group at N2 of a 2'-deoxyguanosine residue in double-stranded DNA." [PMID:11592983] subset: gosubset_prok is_a: GO:0006304 ! DNA modification [Term] id: GO:0030593 name: neutrophil chemotaxis namespace: biological_process def: "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0030594 name: neurotransmitter receptor activity namespace: molecular_function def: "Combining with a neurotransmitter to initiate a change in cell activity." [GOC:jl] is_a: GO:0004872 ! receptor activity is_a: GO:0042165 ! neurotransmitter binding [Term] id: GO:0030595 name: leukocyte chemotaxis namespace: biological_process def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl] synonym: "immune cell chemotaxis" EXACT [] synonym: "leucocyte chemotaxis" EXACT [] is_a: GO:0050900 ! leukocyte migration is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0030596 name: alpha-L-rhamnosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40] subset: gosubset_prok synonym: "alpha-L-rhamnosidase N" RELATED [EC:3.2.1.40] synonym: "alpha-L-rhamnosidase T" RELATED [EC:3.2.1.40] synonym: "alpha-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.40] xref: EC:3.2.1.40 xref: MetaCyc:3.2.1.40-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0030597 name: RNA glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule." [GOC:mah] subset: gosubset_prok is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0030598 name: rRNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah] subset: gosubset_prok synonym: "gelonin" RELATED [EC:3.2.2.22] synonym: "mirabilis antiviral protein" RELATED [EC:3.2.2.22] synonym: "momorcochin-S" RELATED [EC:3.2.2.22] synonym: "nigrin b" RELATED [EC:3.2.2.22] synonym: "ribosomal ribonucleate N-glycosidase activity" EXACT [EC:3.2.2.22] synonym: "ricin" RELATED [EC:3.2.2.22] synonym: "RNA N-glycosidase activity" EXACT [EC:3.2.2.22] synonym: "rRNA N-glycohydrolase activity" EXACT [EC:3.2.2.22] synonym: "rRNA N-glycosidase activity" EXACT [] synonym: "saporins" RELATED [EC:3.2.2.22] xref: EC:3.2.2.22 xref: MetaCyc:3.2.2.22-RXN is_a: GO:0030597 ! RNA glycosylase activity [Term] id: GO:0030599 name: pectinesterase activity namespace: molecular_function def: "Catalysis of the reaction: pectin + n H2O = n methanol + pectate." [EC:3.1.1.11] subset: gosubset_prok synonym: "pectase activity" EXACT [EC:3.1.1.11] synonym: "pectin demethoxylase activity" EXACT [EC:3.1.1.11] synonym: "pectin methoxylase activity" EXACT [EC:3.1.1.11] synonym: "pectin methyl esterase activity" EXACT [EC:3.1.1.11] synonym: "pectin methylesterase activity" EXACT [] synonym: "pectin pectylhydrolase activity" EXACT [EC:3.1.1.11] synonym: "pectinoesterase activity" EXACT [EC:3.1.1.11] xref: EC:3.1.1.11 xref: MetaCyc:PECTINESTERASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0030600 name: feruloyl esterase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73] synonym: "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity" EXACT [EC:3.1.1.73] synonym: "cinnAE" RELATED [EC:3.1.1.73] synonym: "cinnamoyl ester hydrolase activity" EXACT [] synonym: "FAE-I" RELATED [EC:3.1.1.73] synonym: "FAE-II" RELATED [EC:3.1.1.73] synonym: "FAE-III" RELATED [EC:3.1.1.73] synonym: "FAEA" RELATED [EC:3.1.1.73] synonym: "ferulic acid esterase activity" EXACT [EC:3.1.1.73] synonym: "hemicellulase accessory" RELATED [EC:3.1.1.73] synonym: "hydroxycinnamoyl esterase activity" EXACT [EC:3.1.1.73] xref: EC:3.1.1.73 xref: MetaCyc:3.1.1.73-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0030601 name: aminopeptidase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6] comment: This term was made obsolete because it represents a gene product. synonym: "arginyl aminopeptidase activity" EXACT [] synonym: "arylamidase II" RELATED [EC:3.4.11.6] synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6] synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6] synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6] xref: EC:3.4.11.6 xref: MetaCyc:3.4.11.6-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0030602 name: chymosin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4] comment: This term was made obsolete because it represents a gene product. synonym: "rennin" RELATED [EC:3.4.23.4] synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4] xref: EC:3.4.23.4 xref: MetaCyc:3.4.23.4-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0030603 name: oxaloacetase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate." [EC:3.7.1.1, RHEA:24435] synonym: "oxalacetic hydrolase activity" EXACT [EC:3.7.1.1] synonym: "oxaloacetate acetylhydrolase activity" EXACT [EC:3.7.1.1] xref: EC:3.7.1.1 xref: KEGG:R00338 xref: MetaCyc:OXALOACETASE-RXN xref: RHEA:24435 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0030604 name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH." [EC:1.1.1.267, RHEA:13720] subset: gosubset_prok synonym: "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity" EXACT [EC:1.1.1.267] synonym: "1-deoxyxylulose-5-phosphate reductoisomerase activity" EXACT [EC:1.1.1.267] synonym: "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.267] synonym: "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity" EXACT [EC:1.1.1.267] synonym: "DOXP reductoisomerase activity" EXACT [] synonym: "DXP-reductoisomerase activity" EXACT [EC:1.1.1.267] xref: EC:1.1.1.267 xref: KEGG:R05688 xref: MetaCyc:DXPREDISOM-RXN xref: RHEA:13720 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030611 name: arsenate reductase activity namespace: molecular_function def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah] subset: gosubset_prok is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0030612 name: arsenate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin." [MetaCyc:RXN-10737] xref: MetaCyc:RXN-10737 is_a: GO:0030611 ! arsenate reductase activity [Term] id: GO:0030613 name: oxidoreductase activity, acting on phosphorus or arsenic in donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah] comment: Note that enzymes of class EC:1.20.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" NARROW [] xref: EC:1.20 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0030614 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah] subset: gosubset_prok synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor" EXACT [] xref: EC:1.20.4 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0030616 name: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity namespace: molecular_function def: "A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] comment: Note that this term can be used in place of the obsolete molecular function term 'common-partner SMAD protein ; GO:0005073' and is useful for annotating proteins of the SMAD family. synonym: "common-partner SMAD protein" RELATED [] synonym: "TGF-beta receptor, common-partner cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, common-partner cytoplasmic mediator activity" EXACT [] is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: GO:0030617 name: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity namespace: molecular_function def: "A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503] comment: Note that this term can be used in place of the obsolete molecular function term 'inhibitory SMAD protein ; GO:0005074' and is useful for annotating proteins of the SMAD family. synonym: "inhibitory SMAD protein" RELATED [] synonym: "TGF-beta receptor, inhibitory cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, inhibitory cytoplasmic mediator activity" EXACT [] is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: GO:0030618 name: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity namespace: molecular_function def: "A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] comment: Note that this term can be used in place of the obsolete molecular function term 'pathway-specific SMAD protein ; GO:0005075' and is useful for annotating proteins of the SMAD family. synonym: "pathway-specific SMAD protein" NARROW [] synonym: "TGF-beta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: GO:0030619 name: U1 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030620 name: U2 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030621 name: U4 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030622 name: U4atac snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030623 name: U5 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030624 name: U6atac snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030625 name: U11 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U11 small nuclear RNA (U11 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030626 name: U12 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U12 small nuclear RNA (U12 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030627 name: pre-mRNA 5'-splice site binding namespace: molecular_function def: "Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence." [GOC:jl] synonym: "pre-mRNA 5' splice site binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0030628 name: pre-mRNA 3'-splice site binding namespace: molecular_function def: "Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence." [GOC:jl] synonym: "pre-mRNA 3' splice site binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0030629 name: U6 snRNA 3'-end binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 3' end of the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). synonym: "U6 snRNA 3' end binding" EXACT [] is_a: GO:0017070 ! U6 snRNA binding [Term] id: GO:0030631 name: pyrrolysine incorporation namespace: biological_process def: "The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases." [PMID:11435424, PMID:17204561, RESID:AA0321] subset: gosubset_prok synonym: "lysine methylamine methyltransferase cofactor adduct incorporation" EXACT [RESID:AA0321] synonym: "monomethylamine methyltransferase cofactor lysine adduct incorporation" EXACT [CHEBI:21860] xref: RESID:AA0321 is_a: GO:0006451 ! translational readthrough [Term] id: GO:0030632 name: D-alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid." [CHEBI:15570, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-alanine anabolism" EXACT [] synonym: "D-alanine biosynthesis" EXACT [] synonym: "D-alanine formation" EXACT [] synonym: "D-alanine synthesis" EXACT [] is_a: GO:0046145 ! D-alanine family amino acid biosynthetic process is_a: GO:0046436 ! D-alanine metabolic process is_a: GO:0046437 ! D-amino acid biosynthetic process [Term] id: GO:0030633 name: D-alanine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids." [GOC:mah] subset: gosubset_prok synonym: "D-alanine family amino acid breakdown" EXACT [] synonym: "D-alanine family amino acid catabolism" EXACT [] synonym: "D-alanine family amino acid degradation" EXACT [] is_a: GO:0006524 ! alanine catabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process [Term] id: GO:0030634 name: carbon fixation by acetyl-CoA pathway namespace: biological_process def: "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2)." [PMID:11607093] subset: gosubset_prok synonym: "Ljungdahl-Wood pathway" EXACT [] is_a: GO:0006085 ! acetyl-CoA biosynthetic process is_a: GO:0015977 ! carbon fixation [Term] id: GO:0030635 name: acetate derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving derivatives of acetic acid." [GOC:mah] subset: gosubset_prok synonym: "acetate derivative metabolism" EXACT [] is_a: GO:0006083 ! acetate metabolic process [Term] id: GO:0030636 name: acetate derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of derivatives of acetic acid." [GOC:mah] subset: gosubset_prok synonym: "acetate derivative anabolism" EXACT [] synonym: "acetate derivative biosynthesis" EXACT [] synonym: "acetate derivative formation" EXACT [] synonym: "acetate derivative synthesis" EXACT [] is_a: GO:0019413 ! acetate biosynthetic process is_a: GO:0030635 ! acetate derivative metabolic process [Term] id: GO:0030637 name: acetate derivative catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid." [GOC:ai] subset: gosubset_prok synonym: "acetate derivative breakdown" EXACT [] synonym: "acetate derivative catabolism" EXACT [] synonym: "acetate derivative degradation" EXACT [] is_a: GO:0030635 ! acetate derivative metabolic process is_a: GO:0045733 ! acetate catabolic process [Term] id: GO:0030638 name: polyketide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyketide metabolism" EXACT [] is_a: GO:0030635 ! acetate derivative metabolic process [Term] id: GO:0030639 name: polyketide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyketide anabolism" EXACT [] synonym: "polyketide biosynthesis" EXACT [] synonym: "polyketide formation" EXACT [] synonym: "polyketide synthesis" EXACT [] is_a: GO:0030636 ! acetate derivative biosynthetic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0042181 ! ketone biosynthetic process [Term] id: GO:0030640 name: polyketide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyketide breakdown" EXACT [] synonym: "polyketide catabolism" EXACT [] synonym: "polyketide degradation" EXACT [] is_a: GO:0030637 ! acetate derivative catabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0042182 ! ketone catabolic process [Term] id: GO:0030641 name: regulation of cellular pH namespace: biological_process def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] subset: gosubset_prok synonym: "cellular hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] synonym: "proton homeostasis" EXACT [] is_a: GO:0006885 ! regulation of pH is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis [Term] id: GO:0030642 name: cellular sulfate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell." [GOC:mah] synonym: "sulphate ion homeostasis" BROAD [] is_a: GO:0055063 ! sulfate ion homeostasis is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis [Term] id: GO:0030643 name: cellular phosphate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell." [GOC:mah] is_a: GO:0055062 ! phosphate ion homeostasis is_a: GO:0072502 ! cellular trivalent inorganic anion homeostasis [Term] id: GO:0030644 name: cellular chloride ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell." [GOC:mah] is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis is_a: GO:0055064 ! chloride ion homeostasis [Term] id: GO:0030645 name: glucose catabolic process to butyrate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "butyrate fermentation" EXACT [] synonym: "glucose fermentation to butyrate" EXACT [] is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006113 ! fermentation is_a: GO:0019605 ! butyrate metabolic process [Term] id: GO:0030647 name: aminoglycoside antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminoglycoside antibiotic metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process [Term] id: GO:0030648 name: aminoglycoside antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminoglycoside antibiotic anabolism" EXACT [] synonym: "aminoglycoside antibiotic biosynthesis" EXACT [] synonym: "aminoglycoside antibiotic formation" EXACT [] synonym: "aminoglycoside antibiotic synthesis" EXACT [] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process [Term] id: GO:0030649 name: aminoglycoside antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminoglycoside antibiotic breakdown" EXACT [] synonym: "aminoglycoside antibiotic catabolism" EXACT [] synonym: "aminoglycoside antibiotic degradation" EXACT [] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process [Term] id: GO:0030650 name: peptide antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides with antibiotic activity." [GOC:mah] subset: gosubset_prok synonym: "peptide antibiotic metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0016999 ! antibiotic metabolic process [Term] id: GO:0030651 name: peptide antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity." [GOC:mah] subset: gosubset_prok synonym: "peptide antibiotic anabolism" EXACT [] synonym: "peptide antibiotic biosynthesis" EXACT [] synonym: "peptide antibiotic formation" EXACT [] synonym: "peptide antibiotic synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030650 ! peptide antibiotic metabolic process is_a: GO:0043043 ! peptide biosynthetic process [Term] id: GO:0030652 name: peptide antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity." [GOC:mah] subset: gosubset_prok synonym: "peptide antibiotic breakdown" EXACT [] synonym: "peptide antibiotic catabolism" EXACT [] synonym: "peptide antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030650 ! peptide antibiotic metabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0030653 name: beta-lactam antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-lactam antibiotic metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044106 ! cellular amine metabolic process is_a: GO:0072338 ! cellular lactam metabolic process [Term] id: GO:0030654 name: beta-lactam antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-lactam antibiotic anabolism" EXACT [] synonym: "beta-lactam antibiotic biosynthesis" EXACT [] synonym: "beta-lactam antibiotic formation" EXACT [] synonym: "beta-lactam antibiotic synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process is_a: GO:0072339 ! cellular lactam biosynthetic process [Term] id: GO:0030655 name: beta-lactam antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-lactam antibiotic breakdown" EXACT [] synonym: "beta-lactam antibiotic catabolism" EXACT [] synonym: "beta-lactam antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process is_a: GO:0072340 ! cellular lactam catabolic process [Term] id: GO:0030656 name: regulation of vitamin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah] subset: gosubset_prok synonym: "regulation of vitamin metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0030657 name: regulation of coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. is_obsolete: true consider: GO:0051196 consider: GO:0051199 [Term] id: GO:0030658 name: transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0030133 ! transport vesicle [Term] id: GO:0030659 name: cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] subset: gosubset_prok is_a: GO:0012506 ! vesicle membrane is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0030660 name: Golgi-associated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] synonym: "Golgi vesicle membrane" RELATED [] is_a: GO:0000139 ! Golgi membrane is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0005798 ! Golgi-associated vesicle [Term] id: GO:0030661 name: chitosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a chitosome." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0045009 ! chitosome [Term] id: GO:0030662 name: coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0030135 ! coated vesicle [Term] id: GO:0030663 name: COPI coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah] is_a: GO:0030660 ! Golgi-associated vesicle membrane is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030137 ! COPI-coated vesicle [Term] id: GO:0030665 name: clathrin coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah] is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030136 ! clathrin-coated vesicle [Term] id: GO:0030666 name: endocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0030139 ! endocytic vesicle [Term] id: GO:0030667 name: secretory granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0030141 ! stored secretory granule [Term] id: GO:0030668 name: merozoite dense granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0020026 ! merozoite dense granule [Term] id: GO:0030669 name: clathrin-coated endocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah] is_a: GO:0030665 ! clathrin coated vesicle membrane is_a: GO:0030666 ! endocytic vesicle membrane relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle [Term] id: GO:0030670 name: phagocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah] synonym: "phagosome membrane" EXACT [GOC:mah] is_a: GO:0030666 ! endocytic vesicle membrane relationship: part_of GO:0045335 ! phagocytic vesicle [Term] id: GO:0030671 name: clathrin-coated phagocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah] is_a: GO:0030669 ! clathrin-coated endocytic vesicle membrane is_a: GO:0030670 ! phagocytic vesicle membrane relationship: part_of GO:0045336 ! clathrin-coated phagocytic vesicle [Term] id: GO:0030672 name: synaptic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah] is_a: GO:0030665 ! clathrin coated vesicle membrane is_a: GO:0044456 ! synapse part relationship: part_of GO:0008021 ! synaptic vesicle [Term] id: GO:0030673 name: axolemma namespace: cellular_component def: "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653] synonym: "axonal membrane" EXACT [GOC:vk] xref: NIF_Subcellular:sao250772229 xref: Wikipedia:Axolemma is_a: GO:0032589 ! neuron projection membrane is_a: GO:0033267 ! axon part relationship: part_of GO:0044304 ! main axon [Term] id: GO:0030674 name: protein binding, bridging namespace: molecular_function def: "The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah] subset: gosubset_prok synonym: "protein-protein adaptor" NARROW [] is_a: GO:0005515 ! protein binding is_a: GO:0060090 ! binding, bridging [Term] id: GO:0030675 name: Rac GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rac family." [GOC:mah] synonym: "Rac GAP activity" EXACT [GOC:pg] is_a: GO:0005100 ! Rho GTPase activator activity [Term] id: GO:0030676 name: Rac guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:82047 "Rac guanyl-nucleotide exchange factor activity" is_a: GO:0005089 ! Rho guanyl-nucleotide exchange factor activity [Term] id: GO:0030677 name: ribonuclease P complex namespace: cellular_component def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094] comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA. subset: goslim_pir subset: gosubset_prok synonym: "RNase P complex" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0030678 name: mitochondrial ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094] synonym: "mitochondrial RNase P complex" EXACT [] is_a: GO:0030677 ! ribonuclease P complex is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0030679 name: cyanelle ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] synonym: "cyanelle RNase P complex" EXACT [] is_a: GO:0030681 ! multimeric ribonuclease P complex is_a: GO:0044435 ! plastid part relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0030680 name: dimeric ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species." [GOC:mah, PMID:12045094] subset: gosubset_prok synonym: "dimeric RNase P complex" EXACT [] is_a: GO:0030677 ! ribonuclease P complex [Term] id: GO:0030681 name: multimeric ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species." [GOC:mah, PMID:11142368, PMID:12045094] synonym: "multimeric RNase P complex" EXACT [] is_a: GO:0030677 ! ribonuclease P complex [Term] id: GO:0030682 name: evasion or tolerance of host defense response namespace: biological_process def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "evasion of host defence response" EXACT [] is_a: GO:0044415 ! evasion or tolerance of host defenses is_a: GO:0051807 ! evasion or tolerance of defense response of other organism involved in symbiotic interaction [Term] id: GO:0030683 name: evasion by virus of host immune response namespace: biological_process def: "Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] xref: Reactome:168305 "Inhibition of Interferon Synthesis" xref: Reactome:168888 "Inhibition of IFN-beta" xref: Reactome:168891 "Binding of NS1 to dsRNA" xref: Reactome:168896 "Binding of NS1 to PKR" xref: Reactome:169131 "Inhibition of PKR" is_a: GO:0019049 ! evasion of host defenses by virus is_a: GO:0020012 ! evasion or tolerance of host immune response [Term] id: GO:0030684 name: preribosome namespace: cellular_component def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] subset: goslim_pir is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0030685 name: nucleolar preribosome namespace: cellular_component def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516] is_a: GO:0030684 ! preribosome is_a: GO:0044452 ! nucleolar part [Term] id: GO:0030686 name: 90S preribosome namespace: cellular_component def: "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12150911, PMID:12957375, PMID:15120992] is_a: GO:0030684 ! preribosome [Term] id: GO:0030687 name: preribosome, large subunit precursor namespace: cellular_component def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516] comment: Note that this complex is 66S in Saccharomyces. synonym: "66S preribosome" NARROW [] is_a: GO:0030684 ! preribosome [Term] id: GO:0030688 name: preribosome, small subunit precursor namespace: cellular_component def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516] comment: Note that this complex is 43S in Saccharomyces. synonym: "43S preribosome" NARROW [] is_a: GO:0030684 ! preribosome [Term] id: GO:0030689 name: Noc complex namespace: cellular_component def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671] comment: Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found. subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0030690 name: Noc1p-Noc2p complex namespace: cellular_component def: "A heterodimer associated with 90S and 66S preribosomes in the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. is_a: GO:0030689 ! Noc complex is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044452 ! nucleolar part relationship: part_of GO:0030686 ! 90S preribosome relationship: part_of GO:0030687 ! preribosome, large subunit precursor [Term] id: GO:0030691 name: Noc2p-Noc3p complex namespace: cellular_component def: "A heterodimer associated with 66S preribosomes; also found throughout the nucleoplasm; involved in ribosomal large subunit biogenesis." [PMID:12446671] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. is_a: GO:0030689 ! Noc complex is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044451 ! nucleoplasm part is_a: GO:0044452 ! nucleolar part relationship: part_of GO:0030687 ! preribosome, large subunit precursor [Term] id: GO:0030692 name: Noc4p-Nop14p complex namespace: cellular_component def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "Nop7 complex" EXACT [GOC:jh, GOC:mah] synonym: "Nop7 subcomplex" EXACT [GOC:jh, GOC:mah, PMID:18448671] is_a: GO:0030689 ! Noc complex is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044452 ! nucleolar part relationship: part_of GO:0030686 ! 90S preribosome relationship: part_of GO:0030688 ! preribosome, small subunit precursor [Term] id: GO:0030693 name: caspase activity namespace: molecular_function alt_id: GO:0004199 def: "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-1 activity" NARROW [] synonym: "caspase-10 activity" NARROW [] synonym: "caspase-2 activity" NARROW [] synonym: "caspase-3 activity" NARROW [] synonym: "caspase-4 activity" NARROW [] synonym: "caspase-5 activity" NARROW [] synonym: "caspase-6 activity" NARROW [] synonym: "caspase-7 activity" NARROW [] synonym: "caspase-8 activity" NARROW [] synonym: "caspase-9 activity" NARROW [] synonym: "effector caspase activity" NARROW [] synonym: "signaling (initiator) caspase activity" NARROW [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0030694 name: bacterial-type flagellum basal body, rod namespace: cellular_component def: "The central portion of the flagellar basal body, which spans the periplasm and threads through the rings. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, rod" EXACT [] synonym: "flagellin-based flagellum basal body, rod" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0030695 name: GTPase regulator activity namespace: molecular_function def: "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] subset: gosubset_prok is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity [Term] id: GO:0030696 name: tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"] comment: Note that the term name mentions a specific position within a tRNA because no other names have yet arisen for this activity, and because the position is conserved in nearly all tRNAs. The term nevertheless can be used for activities that methylase an analogous residue at a position other than 54, if such is found, and synonyms that mention positions applicable to other tRNAs or species may also be added. synonym: "RUMT" EXACT [] is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity [Term] id: GO:0030697 name: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"] synonym: "RUMT" BROAD [] synonym: "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity" EXACT [] is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity [Term] id: GO:0030698 name: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"] synonym: "RUMT" BROAD [] is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0030699 name: glycine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin." [EC:1.21.4.2, RHEA:12235] subset: gosubset_prok synonym: "acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)" EXACT [EC:1.21.4.2] xref: EC:1.21.4.2 xref: KEGG:R07226 xref: MetaCyc:RXN-7566 xref: RHEA:12235 is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: GO:0030700 name: glycine reductase complex namespace: cellular_component def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0030701 name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37] subset: gosubset_prok synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.37] synonym: "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD--azoferredoxin (ADP-ribose)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD-azoferredoxin (ADPribose)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.37 xref: MetaCyc:2.4.2.37-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0030702 name: chromatin silencing at centromere namespace: biological_process def: "Repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:mah] synonym: "centromere chromatin silencing" EXACT [GOC:mah] synonym: "centromeric silencing" EXACT [GOC:vw] synonym: "heterochromatic silencing at centromere" EXACT [] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0030703 name: eggshell formation namespace: biological_process def: "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration." [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0030704 name: vitelline membrane formation namespace: biological_process def: "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg." [ISBN:0879694238] is_a: GO:0035803 ! egg coat formation is_a: GO:0085029 ! extracellular matrix assembly [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_generic subset: gosubset_prok is_a: GO:0046907 ! intracellular transport [Term] id: GO:0030706 name: germarium-derived oocyte differentiation namespace: biological_process def: "The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte cell differentiation" RELATED [] is_a: GO:0009994 ! oocyte differentiation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030707 name: ovarian follicle cell development namespace: biological_process def: "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0030708 name: germarium-derived female germ-line cyst encapsulation namespace: biological_process def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336] is_a: GO:0048139 ! female germ-line cyst encapsulation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030709 name: border follicle cell delamination namespace: biological_process def: "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261] synonym: "border cell delamination" BROAD [] is_a: GO:0060232 ! delamination relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030710 name: regulation of border follicle cell delamination namespace: biological_process def: "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261] synonym: "regulation of border cell delamination" BROAD [] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0030709 ! border follicle cell delamination [Term] id: GO:0030711 name: positive regulation of border follicle cell delamination namespace: biological_process def: "Any process that increases the frequency, rate or extent of border cell delamination." [PMID:10822261] synonym: "activation of border follicle cell delamination" NARROW [] synonym: "positive regulation of border cell delamination" BROAD [] synonym: "stimulation of border follicle cell delamination" NARROW [] synonym: "up regulation of border follicle cell delamination" EXACT [] synonym: "up-regulation of border follicle cell delamination" EXACT [] synonym: "upregulation of border follicle cell delamination" EXACT [] is_a: GO:0030710 ! regulation of border follicle cell delamination is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0030709 ! border follicle cell delamination [Term] id: GO:0030712 name: negative regulation of border follicle cell delamination namespace: biological_process def: "Any process that decreases the frequency, rate or extent of border cell delamination." [PMID:10822261] synonym: "down regulation of border follicle cell delamination" EXACT [] synonym: "down-regulation of border follicle cell delamination" EXACT [] synonym: "downregulation of border follicle cell delamination" EXACT [] synonym: "inhibition of border follicle cell delamination" NARROW [] synonym: "negative regulation of border cell delamination" BROAD [] is_a: GO:0030710 ! regulation of border follicle cell delamination is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0030709 ! border follicle cell delamination [Term] id: GO:0030713 name: ovarian follicle cell stalk formation namespace: biological_process def: "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030714 name: anterior/posterior axis specification, follicular epithelium namespace: biological_process def: "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf] synonym: "anterior/posterior axis determination, follicular epithelium" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009798 ! axis specification is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030715 name: oocyte growth in germarium-derived egg chamber namespace: biological_process def: "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0001555 ! oocyte growth relationship: part_of GO:0007295 ! growth of a germarium-derived egg chamber [Term] id: GO:0030716 name: oocyte fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] synonym: "oocyte cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination [Term] id: GO:0030717 name: karyosome formation namespace: biological_process def: "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0030718 name: germ-line stem cell maintenance namespace: biological_process def: "Any process involved in preventing uncommitted germ-line stem cells from differentiating as another cell type." [ISBN:0879694238] is_a: GO:0019827 ! stem cell maintenance [Term] id: GO:0030719 name: P granule organization namespace: biological_process alt_id: GO:0048114 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] synonym: "P granule organization and biogenesis" RELATED [] synonym: "polar granule organisation" EXACT [GOC:curators] synonym: "polar granule organization and biogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0006996 ! organelle organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0030720 name: oocyte localization involved in germarium-derived egg chamber formation namespace: biological_process def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT [] synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT [] synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah] synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb] synonym: "oocyte localization during oogenesis" RELATED [] synonym: "oocyte positioning during oogenesis" NARROW [] synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT [] synonym: "oogenesis, oocyte localization" EXACT [] is_a: GO:0051674 ! localization of cell relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030721 name: spectrosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529] synonym: "spectrosome organisation" EXACT [GOC:curators] synonym: "spectrosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0030722 name: establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0048126 def: "The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. In the insect oocyte, for example, the nucleus is repositioned to a dorso-anterior position." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] synonym: "establishment of localization of oocyte nucleus during oocyte axis determination" BROAD [] synonym: "establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "establishment of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification" EXACT [GOC:mah] synonym: "nucleus positioning in oocyte during oocyte axis determination" BROAD [] synonym: "oocyte axis determination, establishment of localization of nucleus" BROAD [] synonym: "oocyte axis determination, establishment of oocyte nucleus localization" BROAD [] synonym: "oocyte axis determination, establishment of position of nucleus" BROAD [] synonym: "oocyte axis determination, positioning of nucleus" BROAD [] synonym: "oocyte nucleus positioning during oocyte axis determination" BROAD [] is_a: GO:0040023 ! establishment of nucleus localization relationship: part_of GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [Term] id: GO:0030723 name: ovarian fusome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "ovarian fusome organisation" EXACT [GOC:curators] synonym: "ovarian fusome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045478 ! fusome organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030724 name: testicular fusome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "testicular fusome organisation" EXACT [GOC:curators] synonym: "testicular fusome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045478 ! fusome organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0030725 name: germline ring canal formation namespace: biological_process def: "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238] synonym: "ring canal formation" BROAD [] is_a: GO:0043063 ! intercellular bridge organization [Term] id: GO:0030726 name: male germline ring canal formation namespace: biological_process def: "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238] synonym: "spermatocyte ring canal formation" NARROW [] synonym: "testicular ring canal formation" NARROW [] is_a: GO:0030725 ! germline ring canal formation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0030727 name: germarium-derived female germ-line cyst formation namespace: biological_process def: "Formation of a cluster of germ-line cells, in the germarium, derived from a single founder cell (cystoblast). An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240] is_a: GO:0048135 ! female germ-line cyst formation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030728 name: ovulation namespace: biological_process def: "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437] xref: Wikipedia:Ovulation is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0030729 name: acetoacetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.16, RHEA:16120] subset: gosubset_prok synonym: "acetoacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.16] synonym: "acetoacetyl-CoA synthetase activity" EXACT [] xref: EC:6.2.1.16 xref: KEGG:R01357 xref: MetaCyc:ACETOACETATE--COA-LIGASE-RXN xref: RHEA:16120 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0030730 name: sequestering of triglyceride namespace: biological_process def: "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "retention of triacylglycerol" EXACT [] synonym: "retention of triglyceride" EXACT [] synonym: "sequestering of triacylglycerol" EXACT [] synonym: "sequestration of triacylglycerol" EXACT [] synonym: "sequestration of triglyceride" EXACT [] synonym: "storage of triacylglycerol" EXACT [] synonym: "storage of triglyceride" EXACT [] synonym: "triacylglycerol retention" EXACT [] synonym: "triacylglycerol sequestering" EXACT [] synonym: "triacylglycerol sequestration" EXACT [] synonym: "triacylglycerol storage" EXACT [] synonym: "triglyceride retention" EXACT [] synonym: "triglyceride sequestering" EXACT [] synonym: "triglyceride sequestration" EXACT [] synonym: "triglyceride storage" EXACT [] is_a: GO:0019915 ! lipid storage is_a: GO:0051235 ! maintenance of location [Term] id: GO:0030731 name: guanidinoacetate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+)." [EC:2.1.1.2, RHEA:10659] synonym: "GA methylpherase activity" EXACT [EC:2.1.1.2] synonym: "guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] synonym: "guanidinoacetate transmethylase activity" EXACT [EC:2.1.1.2] synonym: "guanidoacetate methyltransferase activity" EXACT [EC:2.1.1.2] synonym: "methionine-guanidinoacetic transmethylase activity" EXACT [EC:2.1.1.2] synonym: "S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] xref: EC:2.1.1.2 xref: KEGG:R01883 xref: MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN xref: RHEA:10659 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030732 name: methionine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12] synonym: "methionine methyltransferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosyl methionine:methionine methyl transferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosylmethionine-methionine methyltransferase activity" EXACT [EC:2.1.1.12] xref: EC:2.1.1.12 xref: MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030733 name: fatty acid O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15] synonym: "fatty acid methyltransferase activity" EXACT [EC:2.1.1.15] synonym: "fatty acid O-methyltransferase activity" EXACT [EC:2.1.1.15] synonym: "fatty-acid O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" EXACT [EC:2.1.1.15] xref: EC:2.1.1.15 xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030734 name: polysaccharide O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18] synonym: "acylpolysacharide 6-methyltransferase activity" EXACT [EC:2.1.1.18] synonym: "polysaccharide methyltransferase activity" EXACT [EC:2.1.1.18] synonym: "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity" EXACT [EC:2.1.1.18] xref: EC:2.1.1.18 xref: MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030735 name: carnosine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+)." [EC:2.1.1.22, RHEA:14208] synonym: "S-adenosyl-L-methionine:carnosine N-methyltransferase activity" EXACT [EC:2.1.1.22] xref: EC:2.1.1.22 xref: KEGG:R02144 xref: MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN xref: RHEA:14208 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030736 name: phenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+)." [EC:2.1.1.25, RHEA:14812] synonym: "PMT" RELATED [EC:2.1.1.25] synonym: "S-adenosyl-L-methionine:phenol O-methyltransferase activity" EXACT [EC:2.1.1.25] xref: EC:2.1.1.25 xref: KEGG:R01239 xref: MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN xref: RHEA:14812 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030737 name: iodophenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.26, RHEA:14316] synonym: "S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity" EXACT [EC:2.1.1.26] xref: EC:2.1.1.26 xref: KEGG:R03746 xref: MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN xref: RHEA:14316 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030738 name: tyramine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.27, RHEA:14868] synonym: "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)" EXACT [EC:2.1.1.27] synonym: "S-adenosyl-L-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] synonym: "S-adenosyl-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] synonym: "tyramine methylpherase activity" EXACT [EC:2.1.1.27] xref: EC:2.1.1.27 xref: KEGG:R02384 xref: MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN xref: RHEA:14868 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030739 name: O-demethylpuromycin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38] subset: gosubset_prok synonym: "O-demethylpuromycin methyltransferase activity" EXACT [EC:2.1.1.38] synonym: "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity" EXACT [EC:2.1.1.38] xref: EC:2.1.1.38 xref: MetaCyc:2.1.1.38-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030740 name: inositol 3-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.39, RHEA:18880] synonym: "inositol L-1-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39] synonym: "myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.39] synonym: "myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "S-adenosylmethionine:myo-inositol 1-methyltransferase activity" EXACT [EC:2.1.1.39] xref: EC:2.1.1.39 xref: KEGG:R01189 xref: MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN xref: RHEA:18880 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030741 name: inositol 1-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.40, RHEA:17568] synonym: "inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.40] synonym: "inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] synonym: "inositol D-1-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "S-adenosylmethionine:myo-inositol 3-methyltransferase activity" RELATED [EC:2.1.1.40] xref: EC:2.1.1.40 xref: KEGG:R01188 xref: MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN xref: RHEA:17568 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030742 name: GTP-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP." [GOC:go_curators] is_a: GO:0005515 ! protein binding [Term] id: GO:0030743 name: rRNA (adenosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.66] subset: gosubset_prok synonym: "ribosomal ribonucleate adenosine 2'-methyltransferase activity" EXACT [EC:2.1.1.66] synonym: "RNA-pentose methylase activity" RELATED [EC:2.1.1.66] synonym: "rRNA adenosine 2'-methylase activity" EXACT [EC:2.1.1.66] synonym: "S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity" EXACT [EC:2.1.1.66] synonym: "thiostrepton-resistance methylase activity" NARROW [EC:2.1.1.66] xref: EC:2.1.1.66 xref: MetaCyc:2.1.1.66-RXN is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0030744 name: luteolin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.42, RHEA:14592] synonym: "luteolin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "luteolin methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-dihydric phenol meta-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-dihydric phenol methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-diphenol m-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] xref: EC:2.1.1.42 xref: KEGG:R03587 xref: MetaCyc:LUTEOLIN-O-METHYLTRANSFERASE-RXN xref: RHEA:14592 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030745 name: dimethylhistidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + NN1,NN1-dimethyl-L-histidine = S-adenosyl-L-homocysteine + NN1,NN1,NN1-trimethyl-L-histidine." [EC:2.1.1.44] synonym: "dimethylhistidine methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "histidine-alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity" EXACT [EC:2.1.1.44] xref: EC:2.1.1.44 xref: MetaCyc:2.1.1.44-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030746 name: isoflavone 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46] synonym: "4'-hydroxyisoflavone methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "isoflavone methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "isoflavone O-methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.46] xref: EC:2.1.1.46 xref: MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030747 name: indolepyruvate C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." [EC:2.1.1.47] synonym: "indolepyruvate 3-methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "indolepyruvate methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "indolepyruvic acid methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] xref: EC:2.1.1.47 xref: MetaCyc:INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030748 name: amine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine." [EC:2.1.1.49] synonym: "arylamine N-methyltransferase activity" NARROW [EC:2.1.1.49] synonym: "nicotine N-methyltransferase activity" NARROW [EC:2.1.1.49] synonym: "S-adenosyl-L-methionine:amine N-methyltransferase activity" EXACT [EC:2.1.1.49] synonym: "tryptamine methyltransferase" NARROW [EC:2.1.1.49] synonym: "tryptamine N-methyltransferase activity" NARROW [EC:2.1.1.49] xref: EC:2.1.1.49 xref: MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030749 name: loganate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50] synonym: "loganate methyltransferase activity" EXACT [EC:2.1.1.50] synonym: "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity" EXACT [EC:2.1.1.50] synonym: "S-adenosyl-L-methionine:loganic acid methyltransferase activity" EXACT [EC:2.1.1.50] xref: EC:2.1.1.50 xref: MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030750 name: putrescine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.53, RHEA:15040] synonym: "putrescine methyltransferase activity" EXACT [EC:2.1.1.53] synonym: "S-adenosyl-L-methionine:putrescine N-methyltransferase activity" EXACT [EC:2.1.1.53] xref: EC:2.1.1.53 xref: KEGG:R01153 xref: MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN xref: RHEA:15040 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030751 name: licodione 2'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.65, RHEA:18524] synonym: "S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity" EXACT [EC:2.1.1.65] xref: EC:2.1.1.65 xref: KEGG:R03623 xref: MetaCyc:LICODIONE-2-O-METHYLTRANSFERASE-RXN xref: RHEA:18524 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030752 name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity namespace: molecular_function alt_id: GO:0030764 def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69] synonym: "bergaptol 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "bergaptol methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "BMT activity" EXACT [EC:2.1.1.69] synonym: "furanocoumarin 5-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "furanocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" EXACT [EC:2.1.1.69] xref: EC:2.1.1.69 xref: MetaCyc:2.1.1.69-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030753 name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity namespace: molecular_function alt_id: GO:0030765 def: "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin." [EC:2.1.1.70] synonym: "furanocoumarin 8-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "furanocoumarin 8-O-methyl-transferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol O-methyltransferase activity" EXACT [] synonym: "XMT activity" RELATED [EC:2.1.1.70] xref: EC:2.1.1.70 xref: KEGG:R02982 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030754 name: apigenin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75] synonym: "flavonoid methyltransferase activity" EXACT [EC:2.1.1.75] synonym: "flavonoid O-methyltransferase activity" BROAD [EC:2.1.1.75] synonym: "S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.75] xref: EC:2.1.1.75 xref: MetaCyc:APIGENIN-4-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030755 name: quercetin 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76] synonym: "flavonoid 3-methyltransferase activity" EXACT [EC:2.1.1.76] synonym: "flavonol 3-O-methyltransferase activity" RELATED [EC:2.1.1.76] synonym: "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity" EXACT [EC:2.1.1.76] xref: EC:2.1.1.76 xref: MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030756 name: isoorientin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin." [EC:2.1.1.78, RHEA:24099] synonym: "isoorientin 3'-methyltransferase activity" EXACT [EC:2.1.1.78] synonym: "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.78] xref: EC:2.1.1.78 xref: KEGG:R03731 xref: MetaCyc:ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN xref: RHEA:24099 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030757 name: 3-methylquercitin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine." [EC:2.1.1.82, RHEA:16184] synonym: "3-methylquercetin 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] synonym: "7-OMT activity" RELATED [EC:2.1.1.82] synonym: "flavonol 7-methyltransferase activity" RELATED [EC:2.1.1.82] synonym: "flavonol 7-O-methyltransferase activity" RELATED [EC:2.1.1.82] synonym: "S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] xref: EC:2.1.1.82 xref: KEGG:R05323 xref: MetaCyc:2.1.1.82-RXN xref: RHEA:16184 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030758 name: 3,7-dimethylquercitin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.83, RHEA:21835] synonym: "3,7-dimethylquercetin 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] synonym: "4'-OMT activity" RELATED [EC:2.1.1.83] synonym: "flavonol 4'-methyltransferase activity" RELATED [EC:2.1.1.83] synonym: "flavonol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83] synonym: "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] synonym: "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] xref: EC:2.1.1.83 xref: KEGG:R03456 xref: MetaCyc:2.1.1.83-RXN xref: RHEA:21835 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030759 name: methylquercetagetin 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.84, RHEA:18720] synonym: "6-OMT" RELATED [EC:2.1.1.84] synonym: "flavonol 6-methyltransferase activity" EXACT [EC:2.1.1.84] synonym: "flavonol 6-O-methyltransferase activity" RELATED [EC:2.1.1.84] synonym: "S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity" EXACT [EC:2.1.1.84] xref: EC:2.1.1.84 xref: KEGG:R04505 xref: MetaCyc:2.1.1.84-RXN xref: RHEA:18720 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030760 name: pyridine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine." [EC:2.1.1.87, RHEA:16896] synonym: "pyridine methyltransferase activity" EXACT [EC:2.1.1.87] synonym: "S-adenosyl-L-methionine:pyridine N-methyltransferase activity" EXACT [EC:2.1.1.87] xref: EC:2.1.1.87 xref: KEGG:R02862 xref: MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN xref: Reactome:82331 "pyridine N-methyltransferase activity" xref: RHEA:16896 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030761 name: 8-hydroxyquercitin 8-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.88, RHEA:16596] synonym: "8-hydroxyquercetin 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] synonym: "flavonol 8-methyltransferase activity" EXACT [EC:2.1.1.88] synonym: "flavonol 8-O-methyltransferase activity" RELATED [EC:2.1.1.88] synonym: "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] xref: EC:2.1.1.88 xref: KEGG:R04398 xref: MetaCyc:2.1.1.88-RXN xref: RHEA:16596 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030762 name: tetrahydrocolumbamine 2-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine." [EC:2.1.1.89, RHEA:22539] synonym: "S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity" EXACT [EC:2.1.1.89] synonym: "tetrahydrocolumbamine methyltransferase activity" EXACT [EC:2.1.1.89] xref: EC:2.1.1.89 xref: KEGG:R04077 xref: MetaCyc:2.1.1.89-RXN xref: RHEA:22539 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030763 name: isobutyraldoxime O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.91, RHEA:10999] synonym: "aldoxime methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "S-adenosylmethionine:aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] xref: EC:2.1.1.91 xref: KEGG:R04169 xref: MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN xref: RHEA:10999 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030766 name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94] synonym: "11-demethyl-17-deacetylvindoline 11-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "tabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] xref: EC:2.1.1.94 xref: MetaCyc:2.1.1.94-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030767 name: 3-hydroxyanthranilate 4-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.97, RHEA:17836] synonym: "3-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.97] synonym: "S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity" EXACT [EC:2.1.1.97] xref: EC:2.1.1.97 xref: KEGG:R02667 xref: MetaCyc:2.1.1.97-RXN xref: RHEA:17836 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030768 name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+)." [EC:2.1.1.99, RHEA:11339] synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "NMT activity" EXACT [EC:2.1.1.99] synonym: "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] xref: EC:2.1.1.99 xref: KEGG:R04013 xref: MetaCyc:2.1.1.99-RXN xref: RHEA:11339 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030769 name: macrocin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin." [EC:2.1.1.101, RHEA:17272] subset: gosubset_prok synonym: "macrocin methyltransferase activity" EXACT [EC:2.1.1.101] synonym: "S-adenosyl-L-methionine-macrocin O-methyltransferase activity" EXACT [EC:2.1.1.101] synonym: "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity" EXACT [EC:2.1.1.101] xref: EC:2.1.1.101 xref: KEGG:R02858 xref: MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN xref: RHEA:17272 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030770 name: demethylmacrocin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin." [EC:2.1.1.102, RHEA:17576] synonym: "demethylmacrocin methyltransferase activity" EXACT [EC:2.1.1.102] synonym: "S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity" EXACT [EC:2.1.1.102] xref: EC:2.1.1.102 xref: KEGG:R02859 xref: MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN xref: RHEA:17576 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030771 name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.105, RHEA:17408] synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.1.1.105] synonym: "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.105] synonym: "S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity" EXACT [EC:2.1.1.105] xref: EC:2.1.1.105 xref: KEGG:R04421 xref: MetaCyc:2.1.1.105-RXN xref: RHEA:17408 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030772 name: tryptophan 2-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+)." [EC:2.1.1.106, RHEA:17324] synonym: "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity" EXACT [EC:2.1.1.106] synonym: "S-adenosylmethionine:tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] synonym: "tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] xref: EC:2.1.1.106 xref: KEGG:R08547 xref: MetaCyc:TRYPTOPHAN-2-C-METHYLTRANSFERASE-RXN xref: RHEA:17324 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030773 name: 6-hydroxymellein O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.108, RHEA:15204] synonym: "6-hydroxymellein methyltransferase activity" EXACT [EC:2.1.1.108] synonym: "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity" EXACT [EC:2.1.1.108] xref: EC:2.1.1.108 xref: KEGG:R03934 xref: MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN xref: RHEA:15204 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030774 name: anthranilate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.111, RHEA:12183] synonym: "anthranilic acid N-methyltransferase activity" EXACT [EC:2.1.1.111] synonym: "S-adenosyl-L-methionine:anthranilate N-methyltransferase activity" EXACT [EC:2.1.1.111] xref: EC:2.1.1.111 xref: KEGG:R00984 xref: MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN xref: RHEA:12183 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030775 name: glucuronoxylan 4-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112] synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" EXACT [EC:2.1.1.112] xref: EC:2.1.1.112 xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030776 name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115] synonym: "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "(rs)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "norreticuline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] xref: EC:2.1.1.115 xref: MetaCyc:2.1.1.115-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030777 name: (S)-scoulerine 9-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.117, RHEA:23811] synonym: "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] synonym: "S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] xref: EC:2.1.1.117 xref: KEGG:R03835 xref: MetaCyc:2.1.1.117-RXN xref: RHEA:23811 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030778 name: columbamine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine." [EC:2.1.1.118, RHEA:15376] synonym: "S-adenosyl-L-methionine:columbamine O-methyltransferase activity" EXACT [EC:2.1.1.118] xref: EC:2.1.1.118 xref: KEGG:R03721 xref: MetaCyc:2.1.1.118-RXN xref: RHEA:15376 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030779 name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+)." [EC:2.1.1.119, RHEA:18544] synonym: "S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity" EXACT [EC:2.1.1.119] xref: EC:2.1.1.119 xref: KEGG:R04707 xref: MetaCyc:2.1.1.119-RXN xref: RHEA:18544 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030780 name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+)." [EC:2.1.1.120, RHEA:21095] synonym: "S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity" EXACT [EC:2.1.1.120] xref: EC:2.1.1.120 xref: KEGG:R04705 xref: MetaCyc:2.1.1.120-RXN xref: RHEA:21095 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030781 name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121] synonym: "S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity" EXACT [EC:2.1.1.121] xref: EC:2.1.1.121 xref: MetaCyc:2.1.1.121-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030782 name: (S)-tetrahydroprotoberberine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122] synonym: "S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] synonym: "tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] xref: EC:2.1.1.122 xref: MetaCyc:2.1.1.122-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030783 name: [cytochrome c]-methionine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123] synonym: "cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] synonym: "S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] xref: EC:2.1.1.123 xref: MetaCyc:2.1.1.123-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030784 name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116] synonym: "S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" EXACT [EC:2.1.1.116] xref: EC:2.1.1.116 xref: MetaCyc:2.1.1.116-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030785 name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127] synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "RuBisCO LSMT activity" EXACT [EC:2.1.1.127] synonym: "rubisco methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "RuBisCO methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.127] xref: EC:2.1.1.127 xref: MetaCyc:2.1.1.127-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030786 name: (RS)-norcoclaurine 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128] synonym: "S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity" EXACT [EC:2.1.1.128] xref: EC:2.1.1.128 xref: MetaCyc:2.1.1.128-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030787 name: inositol 4-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.129, RHEA:23251] synonym: "myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] synonym: "myo-inositol 6-O-methyltransferase activity" RELATED [EC:2.1.1.129] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity" EXACT [EC:2.1.1.129] synonym: "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] xref: EC:2.1.1.129 xref: KEGG:R01190 xref: MetaCyc:2.1.1.129-RXN xref: RHEA:23251 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030788 name: precorrin-2 C20-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A." [EC:2.1.1.130, RHEA:16844] subset: gosubset_prok synonym: "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity" EXACT [EC:2.1.1.130] synonym: "S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity" EXACT [EC:2.1.1.130] xref: EC:2.1.1.130 xref: KEGG:R03948 xref: MetaCyc:2.1.1.130-RXN xref: RHEA:16844 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030789 name: precorrin-3B C17-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131] subset: gosubset_prok synonym: "CobJ" RELATED [EC:2.1.1.131] synonym: "precorrin-3 methylase activity" EXACT [EC:2.1.1.131] synonym: "precorrin-3 methyltransferase activity" EXACT [EC:2.1.1.131] synonym: "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity" EXACT [EC:2.1.1.131] xref: EC:2.1.1.131 xref: MetaCyc:2.1.1.131-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030790 name: chlorophenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136] synonym: "halogenated phenol O-methyltransferase activity" BROAD [EC:2.1.1.136] synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] synonym: "trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] xref: EC:2.1.1.136 xref: MetaCyc:2.1.1.136-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030791 name: arsenite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137] comment: Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792). synonym: "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity" EXACT [EC:2.1.1.137] synonym: "S-adenosyl-L-methionine:arsenite As-methyltransferase activity" EXACT [EC:2.1.1.137] synonym: "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity" EXACT [EC:2.1.1.137] xref: EC:2.1.1.137 xref: MetaCyc:2.1.1.137-RXN xref: UM-BBD_reactionID:r0805 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030792 name: methylarsonite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [EC:2.1.1.138] comment: Note that EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137). xref: EC:2.1.1.- xref: MetaCyc:2.1.1.138-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030793 name: 3'-demethylstaurosporine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine." [EC:2.1.1.139, RHEA:11699] synonym: "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] synonym: "S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] synonym: "staurosporine synthase activity" EXACT [EC:2.1.1.139] xref: EC:2.1.1.139 xref: KEGG:R05757 xref: MetaCyc:2.1.1.139-RXN xref: RHEA:11699 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030794 name: (S)-coclaurine-N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140] synonym: "S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity" EXACT [EC:2.1.1.140] xref: EC:2.1.1.140 xref: MetaCyc:2.1.1.140-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030795 name: jasmonate O-methyltransferase activity namespace: molecular_function alt_id: GO:0045546 def: "Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate." [EC:2.1.1.141] synonym: "jasmonic acid carboxyl methyltransferase activity" EXACT [EC:2.1.1.141] synonym: "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity" EXACT [EC:2.1.1.141] synonym: "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity" EXACT [] xref: EC:2.1.1.141 xref: MetaCyc:RXN1F-28 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030796 name: cycloartenol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.142, RHEA:13140] synonym: "S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity" EXACT [EC:2.1.1.142] synonym: "sterol C-methyltransferase activity" BROAD [EC:2.1.1.142] xref: EC:2.1.1.142 xref: KEGG:R05760 xref: MetaCyc:2.1.1.142-RXN xref: RHEA:13140 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030797 name: 24-methylenesterol C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.143, RHEA:21047] synonym: "24-methylenelophenol C-24(1)-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "24-methylenelophenol C-241-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "SMT(2) activity" NARROW [EC:2.1.1.143] synonym: "SMT2" RELATED [EC:2.1.1.143] xref: EC:2.1.1.143 xref: KEGG:R05776 xref: MetaCyc:2.1.1.143-RXN xref: RHEA:21047 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030798 name: trans-aconitate 2-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity" EXACT [EC:2.1.1.144] xref: EC:2.1.1.144 xref: KEGG:R05763 xref: MetaCyc:RXN0-2441 xref: RHEA:14972 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030799 name: regulation of cyclic nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] subset: gosubset_prok synonym: "regulation of cyclic nucleotide metabolism" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process relationship: regulates GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0030800 name: negative regulation of cyclic nucleotide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "down-regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "downregulation of cyclic nucleotide metabolic process" EXACT [] synonym: "inhibition of cyclic nucleotide metabolic process" NARROW [] synonym: "negative regulation of cyclic nucleotide metabolism" EXACT [] is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process relationship: negatively_regulates GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0030801 name: positive regulation of cyclic nucleotide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] subset: gosubset_prok synonym: "activation of cyclic nucleotide metabolic process" NARROW [] synonym: "positive regulation of cyclic nucleotide metabolism" EXACT [] synonym: "stimulation of cyclic nucleotide metabolic process" NARROW [] synonym: "up regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "up-regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "upregulation of cyclic nucleotide metabolic process" EXACT [] is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process relationship: positively_regulates GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0030802 name: regulation of cyclic nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] subset: gosubset_prok synonym: "regulation of cyclic nucleotide anabolism" EXACT [] synonym: "regulation of cyclic nucleotide biosynthesis" EXACT [] synonym: "regulation of cyclic nucleotide formation" EXACT [] synonym: "regulation of cyclic nucleotide synthesis" EXACT [] is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process is_a: GO:0030808 ! regulation of nucleotide biosynthetic process relationship: regulates GO:0009190 ! cyclic nucleotide biosynthetic process [Term] id: GO:0030803 name: negative regulation of cyclic nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "down-regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "downregulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "inhibition of cyclic nucleotide biosynthetic process" NARROW [] synonym: "negative regulation of cyclic nucleotide anabolism" EXACT [] synonym: "negative regulation of cyclic nucleotide biosynthesis" EXACT [] synonym: "negative regulation of cyclic nucleotide formation" EXACT [] synonym: "negative regulation of cyclic nucleotide synthesis" EXACT [] is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process relationship: negatively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process [Term] id: GO:0030804 name: positive regulation of cyclic nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] subset: gosubset_prok synonym: "activation of cyclic nucleotide biosynthetic process" NARROW [] synonym: "positive regulation of cyclic nucleotide anabolism" EXACT [] synonym: "positive regulation of cyclic nucleotide biosynthesis" EXACT [] synonym: "positive regulation of cyclic nucleotide formation" EXACT [] synonym: "positive regulation of cyclic nucleotide synthesis" EXACT [] synonym: "stimulation of cyclic nucleotide biosynthetic process" NARROW [] synonym: "up regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "up-regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "upregulation of cyclic nucleotide biosynthetic process" EXACT [] is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process relationship: positively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process [Term] id: GO:0030805 name: regulation of cyclic nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] subset: gosubset_prok synonym: "regulation of cyclic nucleotide breakdown" EXACT [] synonym: "regulation of cyclic nucleotide catabolism" EXACT [] synonym: "regulation of cyclic nucleotide degradation" EXACT [] is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process is_a: GO:0030811 ! regulation of nucleotide catabolic process relationship: regulates GO:0009214 ! cyclic nucleotide catabolic process [Term] id: GO:0030806 name: negative regulation of cyclic nucleotide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "down-regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "downregulation of cyclic nucleotide catabolic process" EXACT [] synonym: "inhibition of cyclic nucleotide catabolic process" NARROW [] synonym: "negative regulation of cyclic nucleotide breakdown" EXACT [] synonym: "negative regulation of cyclic nucleotide catabolism" EXACT [] synonym: "negative regulation of cyclic nucleotide degradation" EXACT [] is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process is_a: GO:0030812 ! negative regulation of nucleotide catabolic process relationship: negatively_regulates GO:0009214 ! cyclic nucleotide catabolic process [Term] id: GO:0030807 name: positive regulation of cyclic nucleotide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] subset: gosubset_prok synonym: "activation of cyclic nucleotide catabolic process" NARROW [] synonym: "positive regulation of cyclic nucleotide breakdown" EXACT [] synonym: "positive regulation of cyclic nucleotide catabolism" EXACT [] synonym: "positive regulation of cyclic nucleotide degradation" EXACT [] synonym: "stimulation of cyclic nucleotide catabolic process" NARROW [] synonym: "up regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "up-regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "upregulation of cyclic nucleotide catabolic process" EXACT [] is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process is_a: GO:0030813 ! positive regulation of nucleotide catabolic process relationship: positively_regulates GO:0009214 ! cyclic nucleotide catabolic process [Term] id: GO:0030808 name: regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] subset: gosubset_prok synonym: "regulation of nucleotide anabolism" EXACT [] synonym: "regulation of nucleotide biosynthesis" EXACT [] synonym: "regulation of nucleotide formation" EXACT [] synonym: "regulation of nucleotide synthesis" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030809 name: negative regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] subset: gosubset_prok synonym: "down regulation of nucleotide biosynthetic process" EXACT [] synonym: "down-regulation of nucleotide biosynthetic process" EXACT [] synonym: "downregulation of nucleotide biosynthetic process" EXACT [] synonym: "inhibition of nucleotide biosynthetic process" NARROW [] synonym: "negative regulation of nucleotide anabolism" EXACT [] synonym: "negative regulation of nucleotide biosynthesis" EXACT [] synonym: "negative regulation of nucleotide formation" EXACT [] synonym: "negative regulation of nucleotide synthesis" EXACT [] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030810 name: positive regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] subset: gosubset_prok synonym: "activation of nucleotide biosynthetic process" NARROW [] synonym: "positive regulation of nucleotide anabolism" EXACT [] synonym: "positive regulation of nucleotide biosynthesis" EXACT [] synonym: "positive regulation of nucleotide formation" EXACT [] synonym: "positive regulation of nucleotide synthesis" EXACT [] synonym: "stimulation of nucleotide biosynthetic process" NARROW [] synonym: "up regulation of nucleotide biosynthetic process" EXACT [] synonym: "up-regulation of nucleotide biosynthetic process" EXACT [] synonym: "upregulation of nucleotide biosynthetic process" EXACT [] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030811 name: regulation of nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] subset: gosubset_prok synonym: "regulation of nucleotide breakdown" EXACT [] synonym: "regulation of nucleotide catabolism" EXACT [] synonym: "regulation of nucleotide degradation" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process relationship: regulates GO:0009166 ! nucleotide catabolic process [Term] id: GO:0030812 name: negative regulation of nucleotide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] subset: gosubset_prok synonym: "down regulation of nucleotide catabolic process" EXACT [] synonym: "down-regulation of nucleotide catabolic process" EXACT [] synonym: "downregulation of nucleotide catabolic process" EXACT [] synonym: "inhibition of nucleotide catabolic process" NARROW [] synonym: "negative regulation of nucleotide breakdown" EXACT [] synonym: "negative regulation of nucleotide catabolism" EXACT [] synonym: "negative regulation of nucleotide degradation" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process relationship: negatively_regulates GO:0009166 ! nucleotide catabolic process [Term] id: GO:0030813 name: positive regulation of nucleotide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] subset: gosubset_prok synonym: "activation of nucleotide catabolic process" NARROW [] synonym: "positive regulation of nucleotide breakdown" EXACT [] synonym: "positive regulation of nucleotide catabolism" EXACT [] synonym: "positive regulation of nucleotide degradation" EXACT [] synonym: "stimulation of nucleotide catabolic process" NARROW [] synonym: "up regulation of nucleotide catabolic process" EXACT [] synonym: "up-regulation of nucleotide catabolic process" EXACT [] synonym: "upregulation of nucleotide catabolic process" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process relationship: positively_regulates GO:0009166 ! nucleotide catabolic process [Term] id: GO:0030814 name: regulation of cAMP metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] subset: gosubset_prok synonym: "regulation of 3',5' cAMP metabolic process" EXACT [] synonym: "regulation of 3',5' cAMP metabolism" EXACT [] synonym: "regulation of 3',5'-cAMP metabolic process" EXACT [] synonym: "regulation of 3',5'-cAMP metabolism" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "regulation of cAMP metabolism" EXACT [] synonym: "regulation of cyclic AMP metabolic process" EXACT [] synonym: "regulation of cyclic AMP metabolism" EXACT [] is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process relationship: regulates GO:0046058 ! cAMP metabolic process [Term] id: GO:0030815 name: negative regulation of cAMP metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cAMP metabolic process" EXACT [] synonym: "down-regulation of cAMP metabolic process" EXACT [] synonym: "downregulation of cAMP metabolic process" EXACT [] synonym: "inhibition of cAMP metabolic process" NARROW [] synonym: "negative regulation of 3',5' cAMP metabolic process" EXACT [] synonym: "negative regulation of 3',5' cAMP metabolism" EXACT [] synonym: "negative regulation of 3',5'-cAMP metabolic process" EXACT [] synonym: "negative regulation of 3',5'-cAMP metabolism" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "negative regulation of cAMP metabolism" EXACT [] synonym: "negative regulation of cyclic AMP metabolic process" EXACT [] synonym: "negative regulation of cyclic AMP metabolism" EXACT [] is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process is_a: GO:0030814 ! regulation of cAMP metabolic process relationship: negatively_regulates GO:0046058 ! cAMP metabolic process [Term] id: GO:0030816 name: positive regulation of cAMP metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] subset: gosubset_prok synonym: "activation of cAMP metabolic process" NARROW [] synonym: "positive regulation of 3',5' cAMP metabolic process" EXACT [] synonym: "positive regulation of 3',5' cAMP metabolism" EXACT [] synonym: "positive regulation of 3',5'-cAMP metabolic process" EXACT [] synonym: "positive regulation of 3',5'-cAMP metabolism" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "positive regulation of cAMP metabolism" EXACT [] synonym: "positive regulation of cyclic AMP metabolic process" EXACT [] synonym: "positive regulation of cyclic AMP metabolism" EXACT [] synonym: "stimulation of cAMP metabolic process" NARROW [] synonym: "up regulation of cAMP metabolic process" EXACT [] synonym: "up-regulation of cAMP metabolic process" EXACT [] synonym: "upregulation of cAMP metabolic process" EXACT [] is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process is_a: GO:0030814 ! regulation of cAMP metabolic process relationship: positively_regulates GO:0046058 ! cAMP metabolic process [Term] id: GO:0030817 name: regulation of cAMP biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] subset: gosubset_prok synonym: "regulation of 3',5' cAMP biosynthesis" EXACT [] synonym: "regulation of 3',5' cAMP biosynthetic process" EXACT [] synonym: "regulation of 3',5'-cAMP biosynthesis" EXACT [] synonym: "regulation of 3',5'-cAMP biosynthetic process" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "regulation of cAMP anabolism" EXACT [] synonym: "regulation of cAMP biosynthesis" EXACT [] synonym: "regulation of cAMP formation" EXACT [] synonym: "regulation of cAMP synthesis" EXACT [] synonym: "regulation of cyclic AMP biosynthesis" EXACT [] synonym: "regulation of cyclic AMP biosynthetic process" EXACT [] is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process is_a: GO:0030814 ! regulation of cAMP metabolic process relationship: regulates GO:0006171 ! cAMP biosynthetic process [Term] id: GO:0030818 name: negative regulation of cAMP biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cAMP biosynthetic process" EXACT [] synonym: "down-regulation of cAMP biosynthetic process" EXACT [] synonym: "downregulation of cAMP biosynthetic process" EXACT [] synonym: "inhibition of cAMP biosynthetic process" NARROW [] synonym: "negative regulation of 3',5' cAMP biosynthesis" EXACT [] synonym: "negative regulation of 3',5' cAMP biosynthetic process" EXACT [] synonym: "negative regulation of 3',5'-cAMP biosynthesis" EXACT [] synonym: "negative regulation of 3',5'-cAMP biosynthetic process" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "negative regulation of cAMP anabolism" EXACT [] synonym: "negative regulation of cAMP biosynthesis" EXACT [] synonym: "negative regulation of cAMP formation" EXACT [] synonym: "negative regulation of cAMP synthesis" EXACT [] synonym: "negative regulation of cyclic AMP biosynthesis" EXACT [] synonym: "negative regulation of cyclic AMP biosynthetic process" EXACT [] is_a: GO:0030803 ! negative regulation of cyclic nucleotide biosynthetic process is_a: GO:0030815 ! negative regulation of cAMP metabolic process is_a: GO:0030817 ! regulation of cAMP biosynthetic process relationship: negatively_regulates GO:0006171 ! cAMP biosynthetic process [Term] id: GO:0030819 name: positive regulation of cAMP biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] subset: gosubset_prok synonym: "activation of cAMP biosynthetic process" NARROW [] synonym: "positive regulation of 3',5' cAMP biosynthesis" EXACT [] synonym: "positive regulation of 3',5' cAMP biosynthetic process" EXACT [] synonym: "positive regulation of 3',5'-cAMP biosynthesis" EXACT [] synonym: "positive regulation of 3',5'-cAMP biosynthetic process" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "positive regulation of cAMP anabolism" EXACT [] synonym: "positive regulation of cAMP biosynthesis" EXACT [] synonym: "positive regulation of cAMP formation" EXACT [] synonym: "positive regulation of cAMP synthesis" EXACT [] synonym: "positive regulation of cyclic AMP biosynthesis" EXACT [] synonym: "positive regulation of cyclic AMP biosynthetic process" EXACT [] synonym: "stimulation of cAMP biosynthetic process" NARROW [] synonym: "up regulation of cAMP biosynthetic process" EXACT [] synonym: "up-regulation of cAMP biosynthetic process" EXACT [] synonym: "upregulation of cAMP biosynthetic process" EXACT [] is_a: GO:0030804 ! positive regulation of cyclic nucleotide biosynthetic process is_a: GO:0030816 ! positive regulation of cAMP metabolic process is_a: GO:0030817 ! regulation of cAMP biosynthetic process relationship: positively_regulates GO:0006171 ! cAMP biosynthetic process [Term] id: GO:0030820 name: regulation of cAMP catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] subset: gosubset_prok synonym: "regulation of 3',5' cAMP catabolic process" EXACT [] synonym: "regulation of 3',5' cAMP catabolism" EXACT [] synonym: "regulation of 3',5'-cAMP catabolic process" EXACT [] synonym: "regulation of 3',5'-cAMP catabolism" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "regulation of cAMP breakdown" EXACT [] synonym: "regulation of cAMP catabolism" EXACT [] synonym: "regulation of cAMP degradation" EXACT [] synonym: "regulation of cyclic AMP catabolic process" EXACT [] synonym: "regulation of cyclic AMP catabolism" EXACT [] is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process is_a: GO:0030814 ! regulation of cAMP metabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process relationship: regulates GO:0006198 ! cAMP catabolic process [Term] id: GO:0030821 name: negative regulation of cAMP catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cAMP catabolic process" EXACT [] synonym: "down-regulation of cAMP catabolic process" EXACT [] synonym: "downregulation of cAMP catabolic process" EXACT [] synonym: "inhibition of cAMP catabolic process" NARROW [] synonym: "negative regulation of 3',5' cAMP catabolic process" EXACT [] synonym: "negative regulation of 3',5' cAMP catabolism" EXACT [] synonym: "negative regulation of 3',5'-cAMP catabolic process" EXACT [] synonym: "negative regulation of 3',5'-cAMP catabolism" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "negative regulation of cAMP breakdown" EXACT [] synonym: "negative regulation of cAMP catabolism" EXACT [] synonym: "negative regulation of cAMP degradation" EXACT [] synonym: "negative regulation of cyclic AMP catabolic process" EXACT [] synonym: "negative regulation of cyclic AMP catabolism" EXACT [] is_a: GO:0030806 ! negative regulation of cyclic nucleotide catabolic process is_a: GO:0030815 ! negative regulation of cAMP metabolic process is_a: GO:0030820 ! regulation of cAMP catabolic process is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process relationship: negatively_regulates GO:0006198 ! cAMP catabolic process [Term] id: GO:0030822 name: positive regulation of cAMP catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] subset: gosubset_prok synonym: "activation of cAMP catabolic process" NARROW [] synonym: "positive regulation of 3',5' cAMP catabolic process" EXACT [] synonym: "positive regulation of 3',5' cAMP catabolism" EXACT [] synonym: "positive regulation of 3',5'-cAMP catabolic process" EXACT [] synonym: "positive regulation of 3',5'-cAMP catabolism" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "positive regulation of cAMP breakdown" EXACT [] synonym: "positive regulation of cAMP catabolism" EXACT [] synonym: "positive regulation of cAMP degradation" EXACT [] synonym: "positive regulation of cyclic AMP catabolic process" EXACT [] synonym: "positive regulation of cyclic AMP catabolism" EXACT [] synonym: "stimulation of cAMP catabolic process" NARROW [] synonym: "up regulation of cAMP catabolic process" EXACT [] synonym: "up-regulation of cAMP catabolic process" EXACT [] synonym: "upregulation of cAMP catabolic process" EXACT [] is_a: GO:0030807 ! positive regulation of cyclic nucleotide catabolic process is_a: GO:0030816 ! positive regulation of cAMP metabolic process is_a: GO:0030820 ! regulation of cAMP catabolic process is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process relationship: positively_regulates GO:0006198 ! cAMP catabolic process [Term] id: GO:0030823 name: regulation of cGMP metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] subset: gosubset_prok synonym: "regulation of cGMP metabolism" EXACT [] is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process relationship: regulates GO:0046068 ! cGMP metabolic process [Term] id: GO:0030824 name: negative regulation of cGMP metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cGMP metabolic process" EXACT [] synonym: "down-regulation of cGMP metabolic process" EXACT [] synonym: "downregulation of cGMP metabolic process" EXACT [] synonym: "inhibition of cGMP metabolic process" NARROW [] synonym: "negative regulation of cGMP metabolism" EXACT [] is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process is_a: GO:0030823 ! regulation of cGMP metabolic process relationship: negatively_regulates GO:0046068 ! cGMP metabolic process [Term] id: GO:0030825 name: positive regulation of cGMP metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] subset: gosubset_prok synonym: "activation of cGMP metabolic process" NARROW [] synonym: "positive regulation of cGMP metabolism" EXACT [] synonym: "stimulation of cGMP metabolic process" NARROW [] synonym: "up regulation of cGMP metabolic process" EXACT [] synonym: "up-regulation of cGMP metabolic process" EXACT [] synonym: "upregulation of cGMP metabolic process" EXACT [] is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process is_a: GO:0030823 ! regulation of cGMP metabolic process relationship: positively_regulates GO:0046068 ! cGMP metabolic process [Term] id: GO:0030826 name: regulation of cGMP biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] subset: gosubset_prok synonym: "regulation of cGMP anabolism" EXACT [] synonym: "regulation of cGMP biosynthesis" EXACT [] synonym: "regulation of cGMP formation" EXACT [] synonym: "regulation of cGMP synthesis" EXACT [] is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process is_a: GO:0030823 ! regulation of cGMP metabolic process relationship: regulates GO:0006182 ! cGMP biosynthetic process [Term] id: GO:0030827 name: negative regulation of cGMP biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cGMP biosynthetic process" EXACT [] synonym: "down-regulation of cGMP biosynthetic process" EXACT [] synonym: "downregulation of cGMP biosynthetic process" EXACT [] synonym: "inhibition of cGMP biosynthetic process" NARROW [] synonym: "negative regulation of cGMP anabolism" EXACT [] synonym: "negative regulation of cGMP biosynthesis" EXACT [] synonym: "negative regulation of cGMP formation" EXACT [] synonym: "negative regulation of cGMP synthesis" EXACT [] is_a: GO:0030803 ! negative regulation of cyclic nucleotide biosynthetic process is_a: GO:0030824 ! negative regulation of cGMP metabolic process is_a: GO:0030826 ! regulation of cGMP biosynthetic process relationship: negatively_regulates GO:0006182 ! cGMP biosynthetic process [Term] id: GO:0030828 name: positive regulation of cGMP biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] subset: gosubset_prok synonym: "activation of cGMP biosynthetic process" NARROW [] synonym: "positive regulation of cGMP anabolism" EXACT [] synonym: "positive regulation of cGMP biosynthesis" EXACT [] synonym: "positive regulation of cGMP formation" EXACT [] synonym: "positive regulation of cGMP synthesis" EXACT [] synonym: "stimulation of cGMP biosynthetic process" NARROW [] synonym: "up regulation of cGMP biosynthetic process" EXACT [] synonym: "up-regulation of cGMP biosynthetic process" EXACT [] synonym: "upregulation of cGMP biosynthetic process" EXACT [] is_a: GO:0030804 ! positive regulation of cyclic nucleotide biosynthetic process is_a: GO:0030825 ! positive regulation of cGMP metabolic process is_a: GO:0030826 ! regulation of cGMP biosynthetic process relationship: positively_regulates GO:0006182 ! cGMP biosynthetic process [Term] id: GO:0030829 name: regulation of cGMP catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] subset: gosubset_prok synonym: "regulation of cGMP breakdown" EXACT [] synonym: "regulation of cGMP catabolism" EXACT [] synonym: "regulation of cGMP degradation" EXACT [] is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process is_a: GO:0030823 ! regulation of cGMP metabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process relationship: regulates GO:0046069 ! cGMP catabolic process [Term] id: GO:0030830 name: negative regulation of cGMP catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cGMP catabolic process" EXACT [] synonym: "down-regulation of cGMP catabolic process" EXACT [] synonym: "downregulation of cGMP catabolic process" EXACT [] synonym: "inhibition of cGMP catabolic process" NARROW [] synonym: "negative regulation of cGMP breakdown" EXACT [] synonym: "negative regulation of cGMP catabolism" EXACT [] synonym: "negative regulation of cGMP degradation" EXACT [] is_a: GO:0030806 ! negative regulation of cyclic nucleotide catabolic process is_a: GO:0030824 ! negative regulation of cGMP metabolic process is_a: GO:0030829 ! regulation of cGMP catabolic process is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process relationship: negatively_regulates GO:0046069 ! cGMP catabolic process [Term] id: GO:0030831 name: positive regulation of cGMP catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] subset: gosubset_prok synonym: "activation of cGMP catabolic process" NARROW [] synonym: "positive regulation of cGMP breakdown" EXACT [] synonym: "positive regulation of cGMP catabolism" EXACT [] synonym: "positive regulation of cGMP degradation" EXACT [] synonym: "stimulation of cGMP catabolic process" NARROW [] synonym: "up regulation of cGMP catabolic process" EXACT [] synonym: "up-regulation of cGMP catabolic process" EXACT [] synonym: "upregulation of cGMP catabolic process" EXACT [] is_a: GO:0030807 ! positive regulation of cyclic nucleotide catabolic process is_a: GO:0030825 ! positive regulation of cGMP metabolic process is_a: GO:0030829 ! regulation of cGMP catabolic process is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process relationship: positively_regulates GO:0046069 ! cGMP catabolic process [Term] id: GO:0030832 name: regulation of actin filament length namespace: biological_process def: "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah] comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0032535 ! regulation of cellular component size is_a: GO:0032956 ! regulation of actin cytoskeleton organization [Term] id: GO:0030833 name: regulation of actin filament polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] synonym: "regulation of actin polymerization" EXACT [] is_a: GO:0008064 ! regulation of actin polymerization or depolymerization is_a: GO:0032271 ! regulation of protein polymerization relationship: regulates GO:0030041 ! actin filament polymerization [Term] id: GO:0030834 name: regulation of actin filament depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] synonym: "regulation of actin depolymerization" EXACT [] is_a: GO:0008064 ! regulation of actin polymerization or depolymerization is_a: GO:0043244 ! regulation of protein complex disassembly relationship: regulates GO:0030042 ! actin filament depolymerization [Term] id: GO:0030835 name: negative regulation of actin filament depolymerization namespace: biological_process alt_id: GO:0030044 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837'). synonym: "actin filament stabilization" EXACT [] synonym: "down regulation of actin filament depolymerization" EXACT [] synonym: "down-regulation of actin filament depolymerization" EXACT [] synonym: "downregulation of actin filament depolymerization" EXACT [] synonym: "inhibition of actin filament depolymerization" NARROW [] synonym: "negative regulation of actin depolymerization" EXACT [] synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] is_a: GO:0030834 ! regulation of actin filament depolymerization is_a: GO:0043242 ! negative regulation of protein complex disassembly is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0030042 ! actin filament depolymerization [Term] id: GO:0030836 name: positive regulation of actin filament depolymerization namespace: biological_process alt_id: GO:0030045 def: "Any process that activates or increases the frequency, rate or extent of actin depolymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838'). synonym: "actin filament destabilization" EXACT [] synonym: "activation of actin filament depolymerization" NARROW [] synonym: "positive regulation of actin depolymerization" EXACT [] synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] synonym: "stimulation of actin filament depolymerization" NARROW [] synonym: "up regulation of actin filament depolymerization" EXACT [] synonym: "up-regulation of actin filament depolymerization" EXACT [] synonym: "upregulation of actin filament depolymerization" EXACT [] is_a: GO:0030834 ! regulation of actin filament depolymerization is_a: GO:0043243 ! positive regulation of protein complex disassembly is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0030042 ! actin filament depolymerization [Term] id: GO:0030837 name: negative regulation of actin filament polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835'). synonym: "down regulation of actin filament polymerization" EXACT [] synonym: "down-regulation of actin filament polymerization" EXACT [] synonym: "downregulation of actin filament polymerization" EXACT [] synonym: "inhibition of actin filament polymerization" NARROW [] synonym: "negative regulation of actin polymerization" EXACT [] synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] is_a: GO:0030833 ! regulation of actin filament polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0030041 ! actin filament polymerization [Term] id: GO:0030838 name: positive regulation of actin filament polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836'). synonym: "activation of actin filament polymerization" NARROW [] synonym: "positive regulation of actin polymerization" EXACT [] synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] synonym: "stimulation of actin filament polymerization" NARROW [] synonym: "up regulation of actin filament polymerization" EXACT [] synonym: "up-regulation of actin filament polymerization" EXACT [] synonym: "upregulation of actin filament polymerization" EXACT [] is_a: GO:0030833 ! regulation of actin filament polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0030041 ! actin filament polymerization [Term] id: GO:0030839 name: regulation of intermediate filament polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament." [GOC:mah] is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization relationship: regulates GO:0045107 ! intermediate filament polymerization [Term] id: GO:0030840 name: negative regulation of intermediate filament polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843'). synonym: "down regulation of intermediate filament polymerization" EXACT [] synonym: "down-regulation of intermediate filament polymerization" EXACT [] synonym: "downregulation of intermediate filament polymerization" EXACT [] synonym: "inhibition of intermediate filament polymerization" NARROW [] synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] is_a: GO:0030839 ! regulation of intermediate filament polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0045107 ! intermediate filament polymerization [Term] id: GO:0030841 name: positive regulation of intermediate filament polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844'). synonym: "activation of intermediate filament polymerization" NARROW [] synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] synonym: "stimulation of intermediate filament polymerization" NARROW [] synonym: "up regulation of intermediate filament polymerization" EXACT [] synonym: "up-regulation of intermediate filament polymerization" EXACT [] synonym: "upregulation of intermediate filament polymerization" EXACT [] is_a: GO:0030839 ! regulation of intermediate filament polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0045107 ! intermediate filament polymerization [Term] id: GO:0030842 name: regulation of intermediate filament depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament." [GOC:mah] is_a: GO:0043244 ! regulation of protein complex disassembly is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization relationship: regulates GO:0045106 ! intermediate filament depolymerization [Term] id: GO:0030843 name: negative regulation of intermediate filament depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament polymerization ; GO:0030840'). synonym: "down regulation of intermediate filament depolymerization" EXACT [] synonym: "down-regulation of intermediate filament depolymerization" EXACT [] synonym: "downregulation of intermediate filament depolymerization" EXACT [] synonym: "inhibition of intermediate filament depolymerization" NARROW [] synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] is_a: GO:0030842 ! regulation of intermediate filament depolymerization is_a: GO:0043242 ! negative regulation of protein complex disassembly is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0045106 ! intermediate filament depolymerization [Term] id: GO:0030844 name: positive regulation of intermediate filament depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841'). synonym: "activation of intermediate filament depolymerization" NARROW [] synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] synonym: "stimulation of intermediate filament depolymerization" NARROW [] synonym: "up regulation of intermediate filament depolymerization" EXACT [] synonym: "up-regulation of intermediate filament depolymerization" EXACT [] synonym: "upregulation of intermediate filament depolymerization" EXACT [] is_a: GO:0030842 ! regulation of intermediate filament depolymerization is_a: GO:0043243 ! positive regulation of protein complex disassembly is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0045106 ! intermediate filament depolymerization [Term] id: GO:0030845 name: inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway namespace: biological_process def: "A signaling pathway that results in preventing the activation of phospholipase C in response to a signal." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098] comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase inhibitor activity ; GO:0004859'. synonym: "inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway" EXACT [GOC:mah] synonym: "phospholipase C inhibition" EXACT [GOC:dph, GOC:tb] is_a: GO:0010519 ! negative regulation of phospholipase activity is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway relationship: negatively_regulates GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger [Term] id: GO:0030846 name: termination of RNA polymerase II transcription, poly(A)-coupled namespace: biological_process def: "The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination." [GOC:txnOH, PMID:12944462, PMID:18679429] synonym: "transcription termination from Pol II promoter, poly(A) coupled" RELATED [] synonym: "transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [] is_a: GO:0006369 ! termination of RNA polymerase II transcription [Term] id: GO:0030847 name: termination of RNA polymerase II transcription, exosome-dependent namespace: biological_process def: "The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end." [GOC:txnOH, PMID:12944462, PMID:18679429] synonym: "termination of RNA polymerase II transcription, poly(A)-independent" EXACT [] synonym: "transcription termination from Pol II promoter, poly(A)-independent" EXACT [] synonym: "transcription termination from Pol II promoter, RNA polymerase(A)-independent" EXACT [] is_a: GO:0006369 ! termination of RNA polymerase II transcription [Term] id: GO:0030848 name: threo-3-hydroxyaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate." [EC:4.3.1.16, RHEA:12427] synonym: "3-hydroxyaspartate dehydratase activity" BROAD [GOC:mcc, PMID:10481099] synonym: "L-threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] xref: EC:4.3.1.16 xref: KEGG:R05758 xref: MetaCyc:4.3.1.16-RXN xref: RHEA:12427 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0030849 name: autosome namespace: cellular_component def: "Any chromosome other than a sex chromosome." [GOC:mah] comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism. xref: Wikipedia:Autosome is_a: GO:0005694 ! chromosome [Term] id: GO:0030850 name: prostate gland development namespace: biological_process def: "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751] synonym: "prostate development" EXACT [] is_a: GO:0048608 ! reproductive structure development is_a: GO:0048732 ! gland development relationship: part_of GO:0001655 ! urogenital system development [Term] id: GO:0030851 name: granulocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm] synonym: "granulocyte cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030852 name: regulation of granulocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation relationship: regulates GO:0030851 ! granulocyte differentiation [Term] id: GO:0030853 name: negative regulation of granulocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "down regulation of granulocyte differentiation" EXACT [] synonym: "down-regulation of granulocyte differentiation" EXACT [] synonym: "downregulation of granulocyte differentiation" EXACT [] synonym: "inhibition of granulocyte differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation relationship: negatively_regulates GO:0030851 ! granulocyte differentiation [Term] id: GO:0030854 name: positive regulation of granulocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "activation of granulocyte differentiation" NARROW [] synonym: "stimulation of granulocyte differentiation" NARROW [] synonym: "up regulation of granulocyte differentiation" EXACT [] synonym: "up-regulation of granulocyte differentiation" EXACT [] synonym: "upregulation of granulocyte differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation relationship: positively_regulates GO:0030851 ! granulocyte differentiation [Term] id: GO:0030855 name: epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0030856 name: regulation of epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030857 name: negative regulation of epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "down regulation of epithelial cell differentiation" EXACT [] synonym: "down-regulation of epithelial cell differentiation" EXACT [] synonym: "downregulation of epithelial cell differentiation" EXACT [] synonym: "inhibition of epithelial cell differentiation" NARROW [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030858 name: positive regulation of epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "activation of epithelial cell differentiation" NARROW [] synonym: "stimulation of epithelial cell differentiation" NARROW [] synonym: "up regulation of epithelial cell differentiation" EXACT [] synonym: "up-regulation of epithelial cell differentiation" EXACT [] synonym: "upregulation of epithelial cell differentiation" EXACT [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation relationship: positively_regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030859 name: polarized epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium [Term] id: GO:0030860 name: regulation of polarized epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0030859 ! polarized epithelial cell differentiation [Term] id: GO:0030861 name: negative regulation of polarized epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] synonym: "down regulation of polarized epithelial cell differentiation" EXACT [] synonym: "down-regulation of polarized epithelial cell differentiation" EXACT [] synonym: "downregulation of polarized epithelial cell differentiation" EXACT [] synonym: "inhibition of polarized epithelial cell differentiation" NARROW [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation relationship: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation [Term] id: GO:0030862 name: positive regulation of polarized epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation." [GOC:mah] synonym: "activation of polarized epithelial cell differentiation" NARROW [] synonym: "stimulation of polarized epithelial cell differentiation" NARROW [] synonym: "up regulation of polarized epithelial cell differentiation" EXACT [] synonym: "up-regulation of polarized epithelial cell differentiation" EXACT [] synonym: "upregulation of polarized epithelial cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation relationship: positively_regulates GO:0030859 ! polarized epithelial cell differentiation [Term] id: GO:0030863 name: cortical cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0005856 ! cytoskeleton is_a: GO:0044448 ! cell cortex part [Term] id: GO:0030864 name: cortical actin cytoskeleton namespace: cellular_component def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0030863 ! cortical cytoskeleton is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0030865 name: cortical cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] synonym: "cortical cytoskeleton organisation" EXACT [GOC:curators] synonym: "cortical cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization [Term] id: GO:0030866 name: cortical actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] synonym: "cortical actin cytoskeleton organisation" EXACT [GOC:curators] synonym: "cortical actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0030865 ! cortical cytoskeleton organization [Term] id: GO:0030867 name: rough endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah] synonym: "RER membrane" EXACT [] synonym: "rough ER membrane" EXACT [] is_a: GO:0005789 ! endoplasmic reticulum membrane relationship: part_of GO:0005791 ! rough endoplasmic reticulum [Term] id: GO:0030868 name: smooth endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah] synonym: "SER membrane" EXACT [] synonym: "smooth ER membrane" EXACT [] xref: NIF_Subcellular:sao1596955044 is_a: GO:0005789 ! endoplasmic reticulum membrane relationship: part_of GO:0005790 ! smooth endoplasmic reticulum [Term] id: GO:0030869 name: RENT complex namespace: cellular_component def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389] is_a: GO:0005677 ! chromatin silencing complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0030870 name: Mre11 complex namespace: cellular_component def: "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145] synonym: "MRN complex" EXACT [] synonym: "MRX complex" EXACT [] synonym: "Rad50 complex" EXACT [] synonym: "RAD50-MRE11-NBN complex" EXACT [CORUM:2767] synonym: "Rad50-Rad32-Nbs1 complex" EXACT [] synonym: "RMX complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0030874 name: nucleolar chromatin namespace: cellular_component def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah] is_a: GO:0044452 ! nucleolar part is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0030875 name: rDNA protrusion namespace: cellular_component def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244] comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern. synonym: "ribosomal DNA protrusion" EXACT [] is_a: GO:0044452 ! nucleolar part is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0030874 ! nucleolar chromatin [Term] id: GO:0030876 name: interleukin-20 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-20; comprises an alpha and a beta subunit." [GOC:mah] synonym: "IL-20 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0030877 name: beta-catenin destruction complex namespace: cellular_component def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] synonym: "beta-catenin degradation complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0030878 name: thyroid gland development namespace: biological_process def: "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh] is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0030879 name: mammary gland development namespace: biological_process def: "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833] synonym: "mammogenesis" NARROW [GOC:dph] is_a: GO:0048732 ! gland development [Term] id: GO:0030880 name: RNA polymerase complex namespace: cellular_component def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "multisubunit RNA polymerase" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030881 name: beta-2-microglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-2-microglobulin." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0030882 name: lipid antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid antigen." [PMID:14500461] is_a: GO:0003823 ! antigen binding is_a: GO:0008289 ! lipid binding [Term] id: GO:0030883 name: endogenous lipid antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endogenous cellular lipid antigen." [PMID:14500461] is_a: GO:0030882 ! lipid antigen binding [Term] id: GO:0030884 name: exogenous lipid antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461] is_a: GO:0030882 ! lipid antigen binding [Term] id: GO:0030885 name: regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah] is_a: GO:0002694 ! regulation of leukocyte activation relationship: regulates GO:0001773 ! myeloid dendritic cell activation [Term] id: GO:0030886 name: negative regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah] synonym: "down regulation of myeloid dendritic cell activation" EXACT [] synonym: "down-regulation of myeloid dendritic cell activation" EXACT [] synonym: "downregulation of myeloid dendritic cell activation" EXACT [] synonym: "inhibition of myeloid dendritic cell activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation relationship: negatively_regulates GO:0001773 ! myeloid dendritic cell activation [Term] id: GO:0030887 name: positive regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah] synonym: "activation of myeloid dendritic cell activation" NARROW [] synonym: "stimulation of myeloid dendritic cell activation" NARROW [] synonym: "up regulation of myeloid dendritic cell activation" EXACT [] synonym: "up-regulation of myeloid dendritic cell activation" EXACT [] synonym: "upregulation of myeloid dendritic cell activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation relationship: positively_regulates GO:0001773 ! myeloid dendritic cell activation [Term] id: GO:0030888 name: regulation of B cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell proliferation." [GOC:mah] synonym: "regulation of B lymphocyte proliferation" EXACT [] synonym: "regulation of B-cell proliferation" EXACT [] synonym: "regulation of B-lymphocyte proliferation" EXACT [] is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050864 ! regulation of B cell activation relationship: regulates GO:0042100 ! B cell proliferation [Term] id: GO:0030889 name: negative regulation of B cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." [GOC:mah] synonym: "down regulation of B cell proliferation" EXACT [] synonym: "down-regulation of B cell proliferation" EXACT [] synonym: "downregulation of B cell proliferation" EXACT [] synonym: "inhibition of B cell proliferation" NARROW [] synonym: "negative regulation of B lymphocyte proliferation" EXACT [] synonym: "negative regulation of B-cell proliferation" EXACT [] synonym: "negative regulation of B-lymphocyte proliferation" EXACT [] is_a: GO:0030888 ! regulation of B cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050869 ! negative regulation of B cell activation relationship: negatively_regulates GO:0042100 ! B cell proliferation [Term] id: GO:0030890 name: positive regulation of B cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah] synonym: "activation of B cell proliferation" NARROW [] synonym: "positive regulation of B lymphocyte proliferation" EXACT [] synonym: "positive regulation of B-cell proliferation" EXACT [] synonym: "positive regulation of B-lymphocyte proliferation" EXACT [] synonym: "stimulation of B cell proliferation" NARROW [] synonym: "up regulation of B cell proliferation" EXACT [] synonym: "up-regulation of B cell proliferation" EXACT [] synonym: "upregulation of B cell proliferation" EXACT [] is_a: GO:0030888 ! regulation of B cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation is_a: GO:0050871 ! positive regulation of B cell activation relationship: positively_regulates GO:0042100 ! B cell proliferation [Term] id: GO:0030891 name: VCB complex namespace: cellular_component def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071] synonym: "pVHL-elongin C-elongin B complex" EXACT [] synonym: "VHL complex" EXACT [] synonym: "von Hippel-Lindau tumor suppressor complex" EXACT [] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex [Term] id: GO:0030892 name: mitotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522] is_a: GO:0008278 ! cohesin complex [Term] id: GO:0030893 name: meiotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522] is_a: GO:0008278 ! cohesin complex [Term] id: GO:0030894 name: replisome namespace: cellular_component def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] subset: goslim_pir subset: gosubset_prok synonym: "DNA synthesome complex" RELATED [CORUM:1001] synonym: "RC complex" RELATED [CORUM:309, PMID:12006500] synonym: "replication-competent complex" RELATED [CORUM:309, PMID:12006500] xref: Wikipedia:Replisome is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005657 ! replication fork [Term] id: GO:0030895 name: apolipoprotein B mRNA editing enzyme complex namespace: cellular_component def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591] synonym: "apoB mRNA editing enzyme complex" EXACT [] synonym: "APOBEC" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0030896 name: checkpoint clamp complex namespace: cellular_component def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008] comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p. synonym: "CCC" EXACT [] synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0030897 name: HOPS complex namespace: cellular_component def: "A multimeric protein complex that associates with the vacuolar membrane and is involved in homotypic vacuole fusion and vacuole protein sorting. For example, the Saccharomyces complex contains Vps41p, Vam6p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:10944212] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0030898 name: actin-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah] synonym: "actin-activated ATPase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0030899 name: calcium-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)." [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0030900 name: forebrain development namespace: biological_process def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain] synonym: "prosencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0030901 name: midbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain] synonym: "mesencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0030902 name: hindbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain] synonym: "rhombencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0030903 name: notochord development namespace: biological_process def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh] is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0030904 name: retromer complex namespace: cellular_component def: "A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p." [PMID:9700157] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030905 name: retromer complex, outer shell namespace: cellular_component def: "One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer." [PMID:9700157] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0030904 ! retromer complex [Term] id: GO:0030906 name: retromer complex, inner shell namespace: cellular_component def: "One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p." [PMID:9700157] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0030904 ! retromer complex [Term] id: GO:0030907 name: MBF transcription complex namespace: cellular_component def: "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385] synonym: "DSC1 transcription factor complex" EXACT [] synonym: "MBF" EXACT [] synonym: "Mlu1-box binding factor" EXACT [] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0030908 name: protein splicing namespace: biological_process def: "The post-translational removal of peptide sequences from within a protein sequence." [GOC:mah] subset: gosubset_prok xref: Wikipedia:Protein_splicing is_a: GO:0016485 ! protein processing [Term] id: GO:0030909 name: non-intein-mediated protein splicing namespace: biological_process def: "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins." [GOC:mah] subset: gosubset_prok is_a: GO:0030908 ! protein splicing [Term] id: GO:0030910 name: olfactory placode formation namespace: biological_process def: "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0043584 ! nose development relationship: part_of GO:0071699 ! olfactory placode morphogenesis [Term] id: GO:0030911 name: TPR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030912 name: response to deep water namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle." [GOC:mah] comment: Note that this term should not be confused with 'response to flooding ; GO:0009413'; which refers to immersion in water on a shorter time scale. is_a: GO:0009415 ! response to water [Term] id: GO:0030913 name: paranodal junction assembly namespace: biological_process def: "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier." [PMID:14715942] synonym: "paranodal axoglial junction formation" EXACT [PMID:18803321] synonym: "paranodal junction biosynthesis" EXACT [] synonym: "paranodal junction formation" EXACT [] is_a: GO:0007043 ! cell-cell junction assembly is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0032288 ! myelin assembly [Term] id: GO:0030914 name: STAGA complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs." [PMID:11564863] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "SPT3-TAF9-GCN5 acetylase complex" EXACT [GOC:rl, PMID:18838386] synonym: "STAGA coactivator complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0030915 name: Smc5-Smc6 complex namespace: cellular_component def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0030916 name: otic vesicle formation namespace: biological_process def: "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh] synonym: "otocyst biosynthesis" EXACT [] synonym: "otocyst formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0071600 ! otic vesicle morphogenesis [Term] id: GO:0030917 name: midbrain-hindbrain boundary development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh] synonym: "isthmic organizer development" EXACT [] synonym: "isthmomesencephalic boundary development" EXACT [] synonym: "isthmus development" EXACT [] synonym: "MHB development" EXACT [] synonym: "midbrain-hindbrain orgainizer development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0030919 name: peptidyl-serine O-acetylation namespace: biological_process def: "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine." [PMID:489587, PMID:7309355, RESID:AA0364] subset: gosubset_prok xref: RESID:AA0364 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030920 ! peptidyl-serine acetylation [Term] id: GO:0030920 name: peptidyl-serine acetylation namespace: biological_process def: "The acetylation of peptidyl-serine." [GOC:mah] subset: gosubset_prok is_a: GO:0006473 ! protein acetylation [Term] id: GO:0030921 name: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine namespace: biological_process def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:9631087, RESID:AA0183] subset: gosubset_prok xref: RESID:AA0183 is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation [Term] id: GO:0030922 name: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine namespace: biological_process def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:12623015, RESID:AA0365] subset: gosubset_prok xref: RESID:AA0365 is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation [Term] id: GO:0030923 name: metal incorporation into metallo-oxygen cluster namespace: biological_process def: "The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate." [GOC:jsg] subset: gosubset_prok is_a: GO:0006464 ! protein modification process [Term] id: GO:0030924 name: manganese incorporation into metallo-oxygen cluster namespace: biological_process def: "The incorporation of manganese into a metallo-oxygen cluster." [GOC:jsg] subset: gosubset_prok is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster [Term] id: GO:0030925 name: calcium incorporation into metallo-oxygen cluster namespace: biological_process def: "The incorporation of calcium into a metallo-oxygen cluster." [GOC:jsg] subset: gosubset_prok is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster [Term] id: GO:0030926 name: calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide namespace: biological_process def: "The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] subset: gosubset_prok xref: RESID:AA0366 is_a: GO:0030925 ! calcium incorporation into metallo-oxygen cluster [Term] id: GO:0030927 name: manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide namespace: biological_process def: "The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] subset: gosubset_prok xref: RESID:AA0366 is_a: GO:0030924 ! manganese incorporation into metallo-oxygen cluster [Term] id: GO:0030929 name: ADPG pyrophosphorylase complex namespace: cellular_component def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0030930 name: homotetrameric ADPG pyrophosphorylase complex namespace: cellular_component def: "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0030929 ! ADPG pyrophosphorylase complex [Term] id: GO:0030931 name: heterotetrameric ADPG pyrophosphorylase complex namespace: cellular_component def: "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030929 ! ADPG pyrophosphorylase complex [Term] id: GO:0030932 name: amyloplast ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah] is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0030933 name: chloroplast ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah] is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex is_a: GO:0044434 ! chloroplast part [Term] id: GO:0030934 name: anchoring collagen namespace: cellular_component def: "Any collagen polymer which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976] synonym: "connecting collagen" EXACT [ISBN:0721639976] synonym: "linking collagen" EXACT [ISBN:0721639976] is_a: GO:0005581 ! collagen [Term] id: GO:0030935 name: sheet-forming collagen namespace: cellular_component def: "Any collagen polymer in which collagen triple helices associate to form sheet-like networks." [ISBN:0721639976] synonym: "network-forming collagen" EXACT [ISBN:0815316194] is_a: GO:0005581 ! collagen [Term] id: GO:0030936 name: transmembrane collagen namespace: cellular_component def: "Any collagen polymer that passes through a lipid bilayer membrane." [ISBN:0721639976] synonym: "MACIT" EXACT [ISBN:0198599587] is_a: GO:0005581 ! collagen [Term] id: GO:0030937 name: collagen type XVII namespace: cellular_component def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices associate with hemidesmosomes and the basal lamina." [ISBN:0721639976] is_a: GO:0030936 ! transmembrane collagen [Term] id: GO:0030938 name: collagen type XVIII namespace: cellular_component def: "A collagen homotrimer of alpha1(XVIII) chains." [ISBN:0721639976] is_a: GO:0030934 ! anchoring collagen [Term] id: GO:0030939 name: response to long-day photoperiod namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark." [GOC:pj] comment: This term was made obsolete because it was wrongly defined. is_obsolete: true consider: GO:0048571 [Term] id: GO:0030940 name: response to short-day photoperiod namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light." [GOC:pj] comment: This term was made obsolete because it was wrongly defined. is_obsolete: true consider: GO:0048572 [Term] id: GO:0030941 name: chloroplast targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0030942 name: endoplasmic reticulum signal peptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah] synonym: "ER signal peptide binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0030943 name: mitochondrion targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah] synonym: "mitochondrial targeting sequence binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0030944 name: DDEL sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah] is_a: GO:0046923 ! ER retention sequence binding [Term] id: GO:0030945 name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate namespace: molecular_function def: "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0030946 name: protein tyrosine phosphatase activity, metal-dependent namespace: molecular_function def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions." [GOC:mah] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0030947 name: regulation of vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] synonym: "regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] synonym: "regulation of VEGF receptor signaling pathway" EXACT [] synonym: "regulation of VEGF receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0030948 name: negative regulation of vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] synonym: "down regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of vascular endothelial growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] synonym: "negative regulation of VEGF receptor signaling pathway" EXACT [] synonym: "negative regulation of VEGF receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway relationship: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0030949 name: positive regulation of vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] synonym: "activation of vascular endothelial growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] synonym: "positive regulation of VEGF receptor signaling pathway" EXACT [] synonym: "positive regulation of VEGF receptor signalling pathway" EXACT [] synonym: "stimulation of vascular endothelial growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway relationship: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0030950 name: establishment or maintenance of actin cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity [Term] id: GO:0030951 name: establishment or maintenance of microtubule cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity [Term] id: GO:0030952 name: establishment or maintenance of cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030953 name: spindle astral microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah] synonym: "astral microtubule organisation" EXACT [GOC:curators] synonym: "astral microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:0031122 ! cytoplasmic microtubule organization [Term] id: GO:0030954 name: spindle astral microtubule nucleation namespace: biological_process def: "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah] is_a: GO:0007020 ! microtubule nucleation is_a: GO:0030953 ! spindle astral microtubule organization [Term] id: GO:0030955 name: potassium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah] subset: gosubset_prok is_a: GO:0031420 ! alkali metal ion binding [Term] id: GO:0030956 name: glutamyl-tRNA(Gln) amidotransferase complex namespace: cellular_component def: "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'. synonym: "AdT" RELATED [GOC:rb] synonym: "GatCAB" NARROW [GOC:rb] synonym: "GatFAB" NARROW [GOC:rb] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030957 name: Tat protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0030958 name: RITS complex namespace: cellular_component def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433] is_a: GO:0031332 ! RNAi effector complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0005720 ! nuclear heterochromatin [Term] id: GO:0030959 name: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine namespace: biological_process def: "The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link." [RESID:AA0367] subset: gosubset_prok xref: RESID:AA0367 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0030960 name: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine namespace: biological_process def: "The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link." [PDB:1NGK, PMID:12719529, RESID:AA0368] subset: gosubset_prok xref: RESID:AA0368 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0030961 name: peptidyl-arginine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine." [GOC:mah] subset: gosubset_prok is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0030962 name: peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine namespace: biological_process def: "The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine." [PMID:10978343, RESID:AA0369] subset: gosubset_prok xref: RESID:AA0369 is_a: GO:0030961 ! peptidyl-arginine hydroxylation [Term] id: GO:0030963 name: peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine namespace: biological_process def: "The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine." [PMID:10978343, RESID:AA0370] subset: gosubset_prok xref: RESID:AA0370 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0030964 name: NADH dehydrogenase complex namespace: cellular_component alt_id: GO:0030025 alt_id: GO:0030966 alt_id: GO:0031675 alt_id: GO:0031677 alt_id: GO:0031678 alt_id: GO:0045280 def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'. subset: goslim_pir subset: gosubset_prok synonym: "Complex I" EXACT [] synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW [] synonym: "NADH dehydrogenase complex (quinone)" NARROW [] synonym: "NADH dehydrogenase complex (ubiquinone)" NARROW [] synonym: "NADH:plastoquinone reductase complex" NARROW [] synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW [] xref: Wikipedia:NADH_dehydrogenase is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part [Term] id: GO:0030965 name: plasma membrane electron transport, NADH to quinone namespace: biological_process def: "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase." [GOC:mah, GOC:sd] subset: gosubset_prok is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042774 ! plasma membrane ATP synthesis coupled electron transport [Term] id: GO:0030967 name: ER-nuclear sterol response pathway namespace: biological_process def: "The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of sterol depletion, and resulting in the activation of transcription by SREBP." [GOC:mah, PMID:12923525] synonym: "endoplasmic reticulum to nucleus sterol response pathway" EXACT [] synonym: "endoplasmic reticulum-nuclear sterol response pathway" EXACT [] synonym: "ER to nucleus sterol response pathway" EXACT [] is_a: GO:0032933 ! SREBP-mediated signaling pathway is_a: GO:0071501 ! cellular response to sterol depletion [Term] id: GO:0030968 name: endoplasmic reticulum unfolded protein response namespace: biological_process def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763] comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'. synonym: "ER unfolded protein response" EXACT [] synonym: "erUPR" EXACT [] synonym: "SREBP-mediated signalling pathway" RELATED [] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0034620 ! cellular response to unfolded protein is_a: GO:0034976 ! response to endoplasmic reticulum stress [Term] id: GO:0030969 name: UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response namespace: biological_process def: "The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes." [GOC:mah, PMID:12042763] synonym: "UFP-specific transcription factor mRNA processing during unfolded protein response" RELATED [GOC:dph, GOC:tb] synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" RELATED [] synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" RELATED [] is_a: GO:0006397 ! mRNA processing relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response [Term] id: GO:0030970 name: retrograde protein transport, ER to cytosol namespace: biological_process def: "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744] synonym: "retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [] is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0030971 name: receptor tyrosine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity." [GOC:mah] synonym: "transmembrane receptor protein tyrosine kinase ligand binding" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0030972 name: cleavage of cytosolic proteins involved in apoptosis namespace: biological_process def: "The proteolytic degradation of proteins in the cytosol that contributes to apoptosis." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815332181] synonym: "apoptotic cleavage of cytosolic proteins" EXACT [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0006921 ! cellular component disassembly involved in apoptosis [Term] id: GO:0030973 name: molybdate ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with molybdate (MoO4 2-) ions." [GOC:mlg] subset: gosubset_prok is_a: GO:0043168 ! anion binding [Term] id: GO:0030974 name: thiamine pyrophosphate transport namespace: biological_process def: "The directed movement of thiamine pyrophosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] synonym: "thiamin diphosphate transport" EXACT [] synonym: "thiamin pyrophosphate transport" EXACT [GOC:curators] synonym: "thiamine diphosphate transport" EXACT [] synonym: "TPP transport" EXACT [] is_a: GO:0015888 ! thiamine transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0030975 name: thiamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg] synonym: "thiamin binding" EXACT [GOC:curators] synonym: "vitamin B1 binding" EXACT [] is_a: GO:0019842 ! vitamin binding [Term] id: GO:0030976 name: thiamine pyrophosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg] synonym: "aneurine pyrophosphate binding" EXACT [] synonym: "cocarboxylase binding" EXACT [] synonym: "diphosphothiamin binding" EXACT [] synonym: "thiamin pyrophosphate binding" EXACT [GOc:curators] synonym: "TPP binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0030977 name: taurine binding namespace: molecular_function def: "Interacting selectively and non-covalently with taurine." [GOC:mlg] is_a: GO:0043176 ! amine binding [Term] id: GO:0030978 name: alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah] subset: gosubset_prok synonym: "alpha-glucan metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0030979 name: alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah] synonym: "alpha-glucan anabolism" EXACT [] synonym: "alpha-glucan biosynthesis" EXACT [] synonym: "alpha-glucan formation" EXACT [] synonym: "alpha-glucan synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0030978 ! alpha-glucan metabolic process [Term] id: GO:0030980 name: alpha-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans." [GOC:mah] subset: gosubset_prok synonym: "alpha-glucan breakdown" EXACT [] synonym: "alpha-glucan catabolism" EXACT [] synonym: "alpha-glucan degradation" EXACT [] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0030978 ! alpha-glucan metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0030981 name: cortical microtubule cytoskeleton namespace: cellular_component def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0030863 ! cortical cytoskeleton is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0030982 name: adventurous gliding motility namespace: biological_process def: "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime." [GOC:mlg, PMID:11967173] subset: gosubset_prok synonym: "adventurous gliding movement" EXACT [] is_a: GO:0071976 ! cell gliding [Term] id: GO:0030983 name: mismatched DNA binding namespace: molecular_function alt_id: GO:0032134 def: "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] synonym: "mispair binding" EXACT [] synonym: "mispaired DNA binding" EXACT [] is_a: GO:0003690 ! double-stranded DNA binding [Term] id: GO:0030984 name: kininogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors." [GOC:mah, PMID:9520414] is_a: GO:0005515 ! protein binding [Term] id: GO:0030985 name: high molecular weight kininogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kininogen of high molecular mass." [GOC:mah, PMID:9520414] synonym: "HK binding" EXACT [] synonym: "HMW kininogen binding" EXACT [] is_a: GO:0030984 ! kininogen binding [Term] id: GO:0030986 name: low molecular weight kininogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kininogen of low molecular mass." [GOC:mah, PMID:9520414] synonym: "LK binding" EXACT [] synonym: "LMW kininogen binding" EXACT [] is_a: GO:0030984 ! kininogen binding [Term] id: GO:0030987 name: high molecular weight kininogen receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a high molecular weight kininogen receptor." [GOC:mah] is_a: GO:0005102 ! receptor binding [Term] id: GO:0030988 name: high molecular weight kininogen receptor complex namespace: cellular_component def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0030989 name: dynein-driven meiotic oscillatory nuclear movement namespace: biological_process def: "The cell cycle process in which oscillatory movement of the nucleus during meiotic prophase I occurs. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein. It is known to play a central role in meiotic recombination and homologous chromosome pairing; as observed in S. pombe." [GOC:vw, PMID:16111942, PMID:9572142] synonym: "HNM" EXACT [] synonym: "horsetail movement" EXACT [] synonym: "horsetail nuclear movement" EXACT [GOC:vw] is_a: GO:0022402 ! cell cycle process is_a: GO:0030473 ! nuclear migration along microtubule relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0030990 name: intraflagellar transport particle namespace: cellular_component def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:kmv, PMID:14570576] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0030991 name: intraflagellar transport particle A namespace: cellular_component def: "The smaller subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:kmv, PMID:14570576] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0030990 ! intraflagellar transport particle [Term] id: GO:0030992 name: intraflagellar transport particle B namespace: cellular_component def: "The larger subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:kmv, PMID:14570576] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0030990 ! intraflagellar transport particle [Term] id: GO:0030993 name: axonemal heterotrimeric kinesin-II complex namespace: cellular_component def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kmv, PMID:14570576] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0030994 name: primary cell septum disassembly namespace: biological_process def: "Dissolution of the primary septum during cell separation." [PMID:12665550] synonym: "hydrolysis of primary cell septum" EXACT [] synonym: "primary cell septum hydrolysis" EXACT [] synonym: "primary septum hydrolysis" BROAD [] is_a: GO:0032506 ! cytokinetic process is_a: GO:0071845 ! cellular component disassembly at cellular level relationship: part_of GO:0000920 ! cytokinetic cell separation [Term] id: GO:0030995 name: cell septum edging catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation." [GOC:mah, PMID:15194814] synonym: "cell septum edging hydrolysis" EXACT [] synonym: "hydrolysis of cell septum edging" EXACT [] synonym: "hydrolysis of edging of cell septum" EXACT [] synonym: "septum edging hydrolysis" BROAD [] is_a: GO:0032506 ! cytokinetic process is_a: GO:0044248 ! cellular catabolic process relationship: part_of GO:0000920 ! cytokinetic cell separation [Term] id: GO:0030996 name: cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0006995 ! cellular response to nitrogen starvation is_a: GO:0007050 ! cell cycle arrest [Term] id: GO:0030997 name: regulation of centriole-centriole cohesion namespace: biological_process def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: part_of GO:0007098 ! centrosome cycle relationship: regulates GO:0010457 ! centriole-centriole cohesion [Term] id: GO:0030998 name: linear element namespace: cellular_component def: "A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex." [GOC:jb] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0030999 name: linear element assembly namespace: biological_process def: "The cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:jb, GOC:mah] synonym: "linear element formation" RELATED [GOC:dph] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0031000 name: response to caffeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0031001 name: response to brefeldin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah] is_a: GO:0046677 ! response to antibiotic [Term] id: GO:0031002 name: actin rod namespace: cellular_component def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum." [GOC:kp] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0031003 name: actin tubule namespace: cellular_component def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0031002 ! actin rod [Term] id: GO:0031004 name: potassium ion-transporting ATPase complex namespace: cellular_component def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692, TIGR_TIGRFAMS:TIGR01497] synonym: "Kdp system complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0031005 name: filamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031006 name: filamin-A binding namespace: molecular_function def: "Interacting selectively and non-covalently with filamin-A." [GOC:mah, PMID:11336782] synonym: "ABP-280 binding" NARROW [] synonym: "alpha-filamin binding" NARROW [] synonym: "filamin A binding" EXACT [] synonym: "filamin-1 binding" NARROW [] is_a: GO:0031005 ! filamin binding [Term] id: GO:0031007 name: filamin-B binding namespace: molecular_function def: "Interacting selectively and non-covalently with filamin-B." [GOC:mah, PMID:11336782] synonym: "ABP-278/276 binding" NARROW [] synonym: "beta-filamin binding" NARROW [] synonym: "filamin B binding" EXACT [] synonym: "filamin-3 binding" NARROW [] is_a: GO:0031005 ! filamin binding [Term] id: GO:0031008 name: filamin-C binding namespace: molecular_function def: "Interacting selectively and non-covalently with filamin-C, a filamin isoform that contains an 81 amino acid insertion in repeat 20, not present in filamin-A or -B." [GOC:mah, PMID:11336782] synonym: "ABPL binding" NARROW [] synonym: "filamin C binding" EXACT [] synonym: "filamin-2 binding" NARROW [] synonym: "gamma-filamin binding" NARROW [] is_a: GO:0031005 ! filamin binding [Term] id: GO:0031009 name: plastid ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah] is_a: GO:0030931 ! heterotetrameric ADPG pyrophosphorylase complex is_a: GO:0044435 ! plastid part [Term] id: GO:0031010 name: ISWI complex namespace: cellular_component def: "Any chromatin remodeling complex that contains an ATPase subunit of the ISWI family." [GOC:mah, PMID:15020051] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0031011 name: Ino80 complex namespace: cellular_component def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh] synonym: "INO80 chromatin remodeling complex" EXACT [] is_a: GO:0016585 ! chromatin remodeling complex is_a: GO:0033202 ! DNA helicase complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0031012 name: extracellular matrix namespace: cellular_component def: "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants)." [GOC:mah] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Extracellular_matrix is_a: GO:0044421 ! extracellular region part [Term] id: GO:0031013 name: troponin I binding namespace: molecular_function def: "Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031014 name: troponin T binding namespace: molecular_function def: "Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031015 name: karyopherin docking complex namespace: cellular_component def: "A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357] synonym: "Asm4p-containing complex" NARROW [] synonym: "nuclear pore subcomplex" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005643 ! nuclear pore [Term] id: GO:0031016 name: pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs] xref: Wikipedia:Pancreas is_a: GO:0048513 ! organ development [Term] id: GO:0031017 name: exocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0031016 ! pancreas development relationship: part_of GO:0035272 ! exocrine system development relationship: part_of GO:0055123 ! digestive system development [Term] id: GO:0031018 name: endocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs] xref: Reactome:1253574 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1253575 "Regulation of beta-cell development" xref: Reactome:1253576 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1253577 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1253579 "Regulation of gene expression in beta cells" xref: Reactome:1280509 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1280510 "Regulation of beta-cell development" xref: Reactome:1280511 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1280512 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1280514 "Regulation of gene expression in beta cells" xref: Reactome:1299339 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1299340 "Regulation of beta-cell development" xref: Reactome:1299341 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1299342 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1299344 "Regulation of gene expression in beta cells" xref: Reactome:1327091 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1327092 "Regulation of beta-cell development" xref: Reactome:1327093 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1327094 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1327096 "Regulation of gene expression in beta cells" xref: Reactome:1353185 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1353186 "Regulation of beta-cell development" xref: Reactome:1353187 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1353188 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1353190 "Regulation of gene expression in beta cells" xref: Reactome:1373363 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1373364 "Regulation of beta-cell development" xref: Reactome:1373365 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1373366 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1373368 "Regulation of gene expression in beta cells" xref: Reactome:1393386 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1393387 "Regulation of beta-cell development" xref: Reactome:1393388 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1393389 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1393391 "Regulation of gene expression in beta cells" xref: Reactome:1417882 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1417883 "Regulation of beta-cell development" xref: Reactome:1417884 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1417885 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1417887 "Regulation of gene expression in beta cells" xref: Reactome:1450972 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1450973 "Regulation of beta-cell development" xref: Reactome:1450974 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1450975 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1450977 "Regulation of gene expression in beta cells" xref: Reactome:1471355 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1471356 "Regulation of beta-cell development" xref: Reactome:1471357 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1471358 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1471363 "Regulation of gene expression in beta cells" xref: Reactome:1483315 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:1483316 "Regulation of beta-cell development" xref: Reactome:1483317 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:1483318 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:1483319 "Regulation of gene expression in beta cells" xref: Reactome:1497000 "Regulation of gene expression in beta cells" xref: Reactome:1497001 "Regulation of beta-cell development" xref: Reactome:1514387 "Regulation of gene expression in beta cells" xref: Reactome:1514388 "Regulation of beta-cell development" xref: Reactome:1521259 "Regulation of gene expression in beta cells" xref: Reactome:1521260 "Regulation of beta-cell development" xref: Reactome:1526967 "Regulation of gene expression in beta cells" xref: Reactome:1526968 "Regulation of beta-cell development" xref: Reactome:1532703 "Regulation of gene expression in beta cells" xref: Reactome:1532704 "Regulation of beta-cell development" xref: Reactome:1536109 "Regulation of gene expression in beta cells" xref: Reactome:1536110 "Regulation of beta-cell development" xref: Reactome:1538071 "Regulation of gene expression in beta cells" xref: Reactome:1538072 "Regulation of beta-cell development" xref: Reactome:1540356 "Regulation of gene expression in beta cells" xref: Reactome:1540357 "Regulation of beta-cell development" xref: Reactome:186712 "Regulation of beta-cell development" xref: Reactome:210744 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" xref: Reactome:210745 "Regulation of gene expression in beta cells" xref: Reactome:210746 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells" xref: Reactome:210747 "Regulation of gene expression in early pancreatic precursor cells" xref: Reactome:210774 "Regulation of Beta-Cell Development" is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0031016 ! pancreas development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0031019 name: mitochondrial mRNA editing complex namespace: cellular_component def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607] synonym: "mitochondrial editosome" EXACT [] is_a: GO:0044429 ! mitochondrial part is_a: GO:0045293 ! mRNA editing complex [Term] id: GO:0031020 name: plastid mRNA editing complex namespace: cellular_component def: "An mRNA editing complex found in a plastid." [GOC:mah] synonym: "plastid editosome" EXACT [] is_a: GO:0044435 ! plastid part is_a: GO:0045293 ! mRNA editing complex [Term] id: GO:0031021 name: interphase microtubule organizing center namespace: cellular_component def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790] synonym: "iMTOC" EXACT [] synonym: "interphase microtubule organising center" EXACT [] synonym: "interphase MTOC" EXACT [] is_a: GO:0005815 ! microtubule organizing center [Term] id: GO:0031022 name: nuclear migration along microfilament namespace: biological_process def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah] synonym: "nuclear migration, microfilament-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0030048 ! actin filament-based movement [Term] id: GO:0031023 name: microtubule organizing center organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "microtubule organising center organisation" EXACT [GOC:curators] synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization relationship: part_of GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031024 name: interphase microtubule organizing center assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center." [GOC:mah, PMID:15068790] synonym: "interphase microtubule organising center biosynthesis" EXACT [] synonym: "interphase microtubule organising center formation" EXACT [] synonym: "interphase microtubule organizing center biogenesis" RELATED [GOC:mah] synonym: "interphase microtubule organizing centre assembly" EXACT [] is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0031025 name: equatorial microtubule organizing center disassembly namespace: biological_process def: "The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis." [GOC:mah, PMID:15068790] synonym: "equatorial microtubule organising center disassembly" EXACT [] is_a: GO:0031121 ! equatorial microtubule organization is_a: GO:0071845 ! cellular component disassembly at cellular level [Term] id: GO:0031026 name: glutamate synthase complex namespace: cellular_component def: "A complex that possesses glutamate synthase activity." [GOC:mah] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031027 name: glutamate synthase complex (NADH) namespace: cellular_component def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] is_a: GO:0031026 ! glutamate synthase complex [Term] id: GO:0031028 name: septation initiation signaling cascade namespace: biological_process def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007] synonym: "septation initiation network" EXACT [] synonym: "septation initiation signaling" EXACT [] synonym: "septation initiation signalling" EXACT [] synonym: "SIN" EXACT [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0007243 ! intracellular protein kinase cascade is_a: GO:0007265 ! Ras protein signal transduction is_a: GO:0031991 ! regulation of contractile ring contraction involved in cell cycle cytokinesis relationship: part_of GO:0000917 ! barrier septum formation [Term] id: GO:0031029 name: regulation of septation initiation signaling cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "regulation of septation initiation network" EXACT [] synonym: "regulation of septation initiation signaling" EXACT [] synonym: "regulation of septation initiation signalling" EXACT [] is_a: GO:0010627 ! regulation of intracellular protein kinase cascade is_a: GO:0032955 ! regulation of barrier septum formation is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0031028 ! septation initiation signaling cascade [Term] id: GO:0031030 name: negative regulation of septation initiation signaling cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "down regulation of septation initiation signaling" EXACT [] synonym: "down-regulation of septation initiation signaling" EXACT [] synonym: "downregulation of septation initiation signaling" EXACT [] synonym: "inhibition of septation initiation signaling" NARROW [] synonym: "negative regulation of septation initiation network" EXACT [] synonym: "negative regulation of septation initiation signaling" EXACT [] synonym: "negative regulation of septation initiation signalling" EXACT [] is_a: GO:0010741 ! negative regulation of intracellular protein kinase cascade is_a: GO:0010974 ! negative regulation of barrier septum formation is_a: GO:0031029 ! regulation of septation initiation signaling cascade is_a: GO:0046580 ! negative regulation of Ras protein signal transduction relationship: negatively_regulates GO:0031028 ! septation initiation signaling cascade [Term] id: GO:0031031 name: positive regulation of septation initiation signaling cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "activation of septation initiation signaling" NARROW [] synonym: "positive regulation of septation initiation network" EXACT [] synonym: "positive regulation of septation initiation signaling" EXACT [] synonym: "positive regulation of septation initiation signalling" EXACT [] synonym: "stimulation of septation initiation signaling" NARROW [] synonym: "up regulation of septation initiation signaling" EXACT [] synonym: "up-regulation of septation initiation signaling" EXACT [] synonym: "upregulation of septation initiation signaling" EXACT [] is_a: GO:0010740 ! positive regulation of intracellular protein kinase cascade is_a: GO:0010973 ! positive regulation of barrier septum formation is_a: GO:0031029 ! regulation of septation initiation signaling cascade is_a: GO:0046579 ! positive regulation of Ras protein signal transduction relationship: positively_regulates GO:0031028 ! septation initiation signaling cascade [Term] id: GO:0031032 name: actomyosin structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. synonym: "actomyosin organization" EXACT [] synonym: "actomyosin structure organisation" EXACT [GOC:curators] synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0031033 name: myosin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules." [GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton. synonym: "myosin filament assembly or disassembly" RELATED [GOC:mah] synonym: "myosin polymerization or depolymerization" RELATED [] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0031034 name: myosin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a filament composed of myosin molecules." [GOC:mah] synonym: "myosin polymerization" RELATED [] is_a: GO:0031033 ! myosin filament organization is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0031035 name: myosin filament disassembly namespace: biological_process def: "The disassembly of a filament composed of myosin molecules." [GOC:mah] synonym: "myosin depolymerization" RELATED [] is_a: GO:0031033 ! myosin filament organization is_a: GO:0043624 ! cellular protein complex disassembly [Term] id: GO:0031036 name: myosin II filament assembly namespace: biological_process def: "The formation of a bipolar filament composed of myosin II molecules." [GOC:mah] synonym: "myosin II polymerization" RELATED [] is_a: GO:0031034 ! myosin filament assembly is_a: GO:0031038 ! myosin II filament organization [Term] id: GO:0031037 name: myosin II filament disassembly namespace: biological_process def: "The disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] synonym: "myosin II depolymerization" RELATED [] is_a: GO:0031035 ! myosin filament disassembly is_a: GO:0031038 ! myosin II filament organization [Term] id: GO:0031038 name: myosin II filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] synonym: "myosin II filament assembly or disassembly" RELATED [GOC:mah] synonym: "myosin II polymerization or depolymerization" RELATED [] is_a: GO:0031033 ! myosin filament organization [Term] id: GO:0031039 name: macronucleus namespace: cellular_component def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns] xref: Wikipedia:Macronucleus is_a: GO:0005634 ! nucleus [Term] id: GO:0031040 name: micronucleus namespace: cellular_component def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns] xref: Wikipedia:Micronucleus is_a: GO:0005634 ! nucleus [Term] id: GO:0031041 name: O-glycan processing, core 5 namespace: biological_process def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-1->3-GalNAc." [GOC:mah, PMID:10580130] subset: gosubset_prok is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031042 name: O-glycan processing, core 6 namespace: biological_process def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-1->6-GalNAc." [GOC:mah, PMID:10580130] subset: gosubset_prok is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031043 name: O-glycan processing, core 7 namespace: biological_process def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-1->6-GalNAc." [GOC:mah, PMID:10580130] subset: gosubset_prok is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031044 name: O-glycan processing, core 8 namespace: biological_process def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-1->3-GalNAc." [GOC:mah, PMID:10580130] subset: gosubset_prok is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031045 name: dense core granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [PMID:14690495] synonym: "dense core vesicle" EXACT [GOC:kmv] is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0031046 name: spindle pole body duplication in cytoplasm namespace: biological_process def: "Construction of a new spindle pole body adjacent to the existing spindle pole body exterior to the outer nuclear envelope." [GOC:clt] is_a: GO:0030474 ! spindle pole body duplication [Term] id: GO:0031047 name: gene silencing by RNA namespace: biological_process def: "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] synonym: "RNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0016458 ! gene silencing [Term] id: GO:0031048 name: chromatin silencing by small RNA namespace: biological_process def: "Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:mtg_lung, GOC:ns] synonym: "RNA interference-like chromatin silencing" EXACT [] synonym: "RNA-mediated chromatin silencing" EXACT [GOC:dph, GOC:tb] synonym: "RNA-mediated TGS" BROAD [] synonym: "RNA-mediated transcriptional silencing" EXACT [] synonym: "RNAi-directed chromatin silencing" EXACT [GOC:vw] synonym: "RNAi-like chromatin silencing" EXACT [] synonym: "small RNA-mediated heterochromatic silencing" EXACT [] is_a: GO:0006342 ! chromatin silencing is_a: GO:0031047 ! gene silencing by RNA [Term] id: GO:0031049 name: programmed DNA elimination namespace: biological_process def: "The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns] subset: goslim_pir is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0031050 name: dsRNA fragmentation namespace: biological_process def: "Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function." [GOC:ns] synonym: "double-stranded RNA fragmentation" EXACT [] is_a: GO:0006396 ! RNA processing is_a: GO:0071359 ! cellular response to dsRNA [Term] id: GO:0031051 name: scnRNA production namespace: biological_process def: "Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome." [PMID:15196465] is_a: GO:0031050 ! dsRNA fragmentation relationship: part_of GO:0031049 ! programmed DNA elimination [Term] id: GO:0031052 name: chromosome breakage namespace: biological_process def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns] comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences. synonym: "establishment or maintenance of heterochromatin architecture" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0031049 ! programmed DNA elimination [Term] id: GO:0031053 name: primary microRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [PMID:15211354] synonym: "pri-miRNA processing" EXACT [] synonym: "primary miRNA processing" EXACT [] is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA [Term] id: GO:0031054 name: pre-microRNA processing namespace: biological_process def: "Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [PMID:15211354] synonym: "pre-miRNA processing" EXACT [] is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA [Term] id: GO:0031055 name: chromatin remodeling at centromere namespace: biological_process def: "Dynamic structural changes in centromeric DNA." [GOC:mah] is_a: GO:0006338 ! chromatin remodeling [Term] id: GO:0031056 name: regulation of histone modification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0033044 ! regulation of chromosome organization relationship: regulates GO:0016570 ! histone modification [Term] id: GO:0031057 name: negative regulation of histone modification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] synonym: "down regulation of histone modification" EXACT [] synonym: "down-regulation of histone modification" EXACT [] synonym: "downregulation of histone modification" EXACT [] synonym: "inhibition of histone modification" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031400 ! negative regulation of protein modification process relationship: negatively_regulates GO:0016570 ! histone modification [Term] id: GO:0031058 name: positive regulation of histone modification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] synonym: "activation of histone modification" NARROW [] synonym: "stimulation of histone modification" NARROW [] synonym: "up regulation of histone modification" EXACT [] synonym: "up-regulation of histone modification" EXACT [] synonym: "upregulation of histone modification" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031401 ! positive regulation of protein modification process relationship: positively_regulates GO:0016570 ! histone modification [Term] id: GO:0031059 name: histone deacetylation at centromere namespace: biological_process def: "The removal of acetyl groups from histones in centromeric DNA." [GOC:mah] is_a: GO:0016575 ! histone deacetylation [Term] id: GO:0031060 name: regulation of histone methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] is_a: GO:0031056 ! regulation of histone modification relationship: regulates GO:0016571 ! histone methylation [Term] id: GO:0031061 name: negative regulation of histone methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] synonym: "down regulation of histone methylation" EXACT [] synonym: "down-regulation of histone methylation" EXACT [] synonym: "downregulation of histone methylation" EXACT [] synonym: "inhibition of histone methylation" NARROW [] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0031060 ! regulation of histone methylation relationship: negatively_regulates GO:0016571 ! histone methylation [Term] id: GO:0031062 name: positive regulation of histone methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] synonym: "activation of histone methylation" NARROW [] synonym: "stimulation of histone methylation" NARROW [] synonym: "up regulation of histone methylation" EXACT [] synonym: "up-regulation of histone methylation" EXACT [] synonym: "upregulation of histone methylation" EXACT [] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0031060 ! regulation of histone methylation relationship: positively_regulates GO:0016571 ! histone methylation [Term] id: GO:0031063 name: regulation of histone deacetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0090311 ! regulation of protein deacetylation relationship: regulates GO:0016575 ! histone deacetylation [Term] id: GO:0031064 name: negative regulation of histone deacetylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] synonym: "down regulation of histone deacetylation" EXACT [] synonym: "down-regulation of histone deacetylation" EXACT [] synonym: "downregulation of histone deacetylation" EXACT [] synonym: "inhibition of histone deacetylation" NARROW [] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0031063 ! regulation of histone deacetylation relationship: negatively_regulates GO:0016575 ! histone deacetylation [Term] id: GO:0031065 name: positive regulation of histone deacetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] synonym: "activation of histone deacetylation" NARROW [] synonym: "stimulation of histone deacetylation" NARROW [] synonym: "up regulation of histone deacetylation" EXACT [] synonym: "up-regulation of histone deacetylation" EXACT [] synonym: "upregulation of histone deacetylation" EXACT [] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0031063 ! regulation of histone deacetylation is_a: GO:0090312 ! positive regulation of protein deacetylation relationship: positively_regulates GO:0016575 ! histone deacetylation [Term] id: GO:0031066 name: regulation of histone deacetylation at centromere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] is_a: GO:0031063 ! regulation of histone deacetylation relationship: regulates GO:0031059 ! histone deacetylation at centromere [Term] id: GO:0031067 name: negative regulation of histone deacetylation at centromere namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA." [GOC:mah] synonym: "down regulation of histone deacetylation at centromere" EXACT [] synonym: "down-regulation of histone deacetylation at centromere" EXACT [] synonym: "downregulation of histone deacetylation at centromere" EXACT [] synonym: "inhibition of histone deacetylation at centromere" NARROW [] is_a: GO:0031064 ! negative regulation of histone deacetylation is_a: GO:0031066 ! regulation of histone deacetylation at centromere relationship: negatively_regulates GO:0031059 ! histone deacetylation at centromere [Term] id: GO:0031068 name: positive regulation of histone deacetylation at centromere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] synonym: "activation of histone deacetylation at centromere" NARROW [] synonym: "stimulation of histone deacetylation at centromere" NARROW [] synonym: "up regulation of histone deacetylation at centromere" EXACT [] synonym: "up-regulation of histone deacetylation at centromere" EXACT [] synonym: "upregulation of histone deacetylation at centromere" EXACT [] is_a: GO:0031065 ! positive regulation of histone deacetylation is_a: GO:0031066 ! regulation of histone deacetylation at centromere relationship: positively_regulates GO:0031059 ! histone deacetylation at centromere [Term] id: GO:0031069 name: hair follicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hair follicle are generated and organized." [GOC:ln] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0022405 ! hair cycle process relationship: part_of GO:0001942 ! hair follicle development relationship: part_of GO:0048730 ! epidermis morphogenesis [Term] id: GO:0031070 name: intronic snoRNA processing namespace: biological_process def: "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA." [GOC:vw] is_a: GO:0043144 ! snoRNA processing [Term] id: GO:0031071 name: cysteine desulfurase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7] subset: gosubset_prok synonym: "cysteine desulfurylase activity" EXACT [EC:2.8.1.7] synonym: "IscS" RELATED [EC:2.8.1.7] synonym: "L-cysteine:enzyme cysteine sulfurtransferase activity" EXACT [EC:2.8.1.7] synonym: "NIFS" RELATED [EC:2.8.1.7] synonym: "NifS" RELATED [EC:2.8.1.7] synonym: "SufS" RELATED [EC:2.8.1.7] xref: EC:2.8.1.7 xref: Reactome:162319 "cysteine desulfurase activity" is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0031072 name: heat shock protein binding namespace: molecular_function def: "Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0031073 name: cholesterol 26-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol." [GOC:mah, PMID:950499] is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0031074 name: nucleocytoplasmic shuttling complex namespace: cellular_component def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031076 name: embryonic camera-type eye development namespace: biological_process def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] synonym: "embryonic eye development" EXACT [] is_a: GO:0043010 ! camera-type eye development is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0031077 name: post-embryonic camera-type eye development namespace: biological_process def: "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] synonym: "post-embryonic camera-style eye development" EXACT [] is_a: GO:0043010 ! camera-type eye development is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0009791 ! post-embryonic development [Term] id: GO:0031078 name: histone deacetylase activity (H3-K14 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, EC:3.5.1.98, RHEA:24551] xref: EC:3.5.1.98 is_a: GO:0004407 ! histone deacetylase activity [Term] id: GO:0031079 name: picornain 3C activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28] comment: This term was made obsolete because it represents a gene product. synonym: "3C protease activity" EXACT [EC:3.4.22.28] synonym: "3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "coxsackievirus 3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28] synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28] synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "hepatitis A virus 3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28] synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28] synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "protease 3C" RELATED [EC:3.4.22.28] synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28] synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28] xref: EC:3.4.22.28 is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0031080 name: Nup107-160 complex namespace: cellular_component def: "A subcomplex of the nuclear pore complex (NPC) involved in mRNA export and NPC assembly. Contains conserved nucleoporins and other proteins; for example, the Saccharomyces complex contains Nup84p, Nup85p, Nup120p, Nup145p-C, Seh1p, Sec13p, and Nup133p." [PMID:10747086, PMID:11823431, PMID:15226438] synonym: "Nup107-120 complex" EXACT [] synonym: "Nup84 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005643 ! nuclear pore [Term] id: GO:0031081 name: nuclear pore distribution namespace: biological_process def: "Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope." [GOC:mah] synonym: "positioning of nuclear pores" RELATED [] is_a: GO:0006997 ! nucleus organization is_a: GO:0051664 ! nuclear pore localization [Term] id: GO:0031082 name: BLOC complex namespace: cellular_component def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0031083 name: BLOC-1 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] is_a: GO:0031082 ! BLOC complex [Term] id: GO:0031084 name: BLOC-2 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569] is_a: GO:0031082 ! BLOC complex [Term] id: GO:0031085 name: BLOC-3 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248] is_a: GO:0031082 ! BLOC complex [Term] id: GO:0031086 name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay namespace: biological_process def: "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544] synonym: "deadenylation-independent mRNA decay" EXACT [] synonym: "deadenylylation-independent mRNA decay" EXACT [] synonym: "mRNA breakdown, deadenylation-independent decay" EXACT [] synonym: "mRNA catabolic process, deadenylation-independent" EXACT [] synonym: "mRNA catabolic process, deadenylylation-independent" EXACT [] synonym: "mRNA catabolism, deadenylation-independent" EXACT [] synonym: "mRNA catabolism, deadenylation-independent decay" EXACT [] synonym: "mRNA catabolism, deadenylylation-independent" EXACT [] synonym: "mRNA degradation, deadenylation-independent decay" EXACT [] synonym: "nuclear mRNA catabolic process, deadenylation-independent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0031087 name: deadenylation-independent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544] synonym: "deadenylation-independent decapping of nuclear mRNA" RELATED [] synonym: "deadenylylation-independent decapping" EXACT [] is_a: GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [Term] id: GO:0031088 name: platelet dense granule membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042827 ! platelet dense granule [Term] id: GO:0031089 name: platelet dense granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0042827 ! platelet dense granule [Term] id: GO:0031090 name: organelle membrane namespace: cellular_component def: "The lipid bilayer surrounding an organelle." [GOC:mah] subset: gosubset_prok is_a: GO:0016020 ! membrane is_a: GO:0044422 ! organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031091 name: platelet alpha granule namespace: cellular_component def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233] synonym: "platelet alpha-granule" EXACT [] xref: Wikipedia:Platelet_alpha-granule is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0031092 name: platelet alpha granule membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233] synonym: "platelet alpha-granule membrane" EXACT [] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0031091 ! platelet alpha granule [Term] id: GO:0031093 name: platelet alpha granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233] synonym: "platelet alpha-granule lumen" EXACT [] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0031091 ! platelet alpha granule [Term] id: GO:0031094 name: platelet dense tubular network namespace: cellular_component def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202] subset: goslim_pir is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0031095 name: platelet dense tubular network membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202] is_a: GO:0031090 ! organelle membrane is_a: GO:0044424 ! intracellular part relationship: part_of GO:0031094 ! platelet dense tubular network [Term] id: GO:0031096 name: platelet dense tubular network lumen namespace: cellular_component def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0031094 ! platelet dense tubular network [Term] id: GO:0031097 name: medial cortex namespace: cellular_component def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation." [GOC:vw, PMID:15572668, PMID:19474789] synonym: "medial ring" EXACT [GOC:vw] is_a: GO:0032155 ! cell division site part is_a: GO:0044448 ! cell cortex part [Term] id: GO:0031098 name: stress-activated protein kinase signaling cascade namespace: biological_process def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals." [GOC:mah] synonym: "JNK signaling pathway" NARROW [] synonym: "JNK signalling pathway" NARROW [] synonym: "SAPK signaling pathway" EXACT [] synonym: "SAPK signalling pathway" EXACT [] synonym: "stress-activated protein kinase signaling pathway" EXACT [] synonym: "stress-activated protein kinase signalling pathway" EXACT [] is_a: GO:0007243 ! intracellular protein kinase cascade is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0031099 name: regeneration namespace: biological_process def: "The regrowth of a lost or destroyed body part, such as an organ or tissue." [GOC:mah] xref: Wikipedia:Regeneration_(biology) is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0031100 name: organ regeneration namespace: biological_process def: "The regrowth of a lost or destroyed organ." [GOC:mah] is_a: GO:0009887 ! organ morphogenesis is_a: GO:0031099 ! regeneration [Term] id: GO:0031101 name: fin regeneration namespace: biological_process def: "The regrowth of fin tissue following its loss or destruction." [GOC:dgh] is_a: GO:0033334 ! fin morphogenesis is_a: GO:0042246 ! tissue regeneration [Term] id: GO:0031102 name: neuron projection regeneration namespace: biological_process def: "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] synonym: "neurite regeneration" NARROW [GOC:mah] is_a: GO:0031099 ! regeneration is_a: GO:0033554 ! cellular response to stress is_a: GO:0048812 ! neuron projection morphogenesis [Term] id: GO:0031103 name: axon regeneration namespace: biological_process def: "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] is_a: GO:0007409 ! axonogenesis is_a: GO:0031102 ! neuron projection regeneration is_a: GO:0048678 ! response to axon injury [Term] id: GO:0031104 name: dendrite regeneration namespace: biological_process def: "The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] is_a: GO:0031102 ! neuron projection regeneration is_a: GO:0048813 ! dendrite morphogenesis [Term] id: GO:0031105 name: septin complex namespace: cellular_component def: "Any of several heterooligomeric complexes containing multiple septins." [GOC:mah, PMID:15385632] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0032156 ! septin cytoskeleton [Term] id: GO:0031106 name: septin ring organization namespace: biological_process def: "Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah] subset: gosubset_prok synonym: "septin ring organisation" EXACT [GOC:curators] is_a: GO:0032185 ! septin cytoskeleton organization [Term] id: GO:0031107 name: septin ring disassembly namespace: biological_process def: "The controlled breakdown of a septin ring." [GOC:mah] is_a: GO:0071845 ! cellular component disassembly at cellular level relationship: part_of GO:0031106 ! septin ring organization [Term] id: GO:0031108 name: holo-[acyl-carrier-protein] biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]." [GOC:mlg] synonym: "holo-[acyl-carrier protein] biosynthesis" EXACT [] synonym: "holo-[acyl-carrier-protein] anabolism" EXACT [] synonym: "holo-[acyl-carrier-protein] biosynthesis" EXACT [] synonym: "holo-[acyl-carrier-protein] formation" EXACT [] synonym: "holo-[acyl-carrier-protein] synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0031109 name: microtubule polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031110 name: regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: regulates GO:0031109 ! microtubule polymerization or depolymerization [Term] id: GO:0031111 name: negative regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "downregulation of microtubule polymerization or depolymerization" EXACT [] synonym: "inhibition of microtubule polymerization or depolymerization" NARROW [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization [Term] id: GO:0031112 name: positive regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "activation of microtubule polymerization or depolymerization" NARROW [] synonym: "stimulation of microtubule polymerization or depolymerization" NARROW [] synonym: "up regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "upregulation of microtubule polymerization or depolymerization" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization [Term] id: GO:0031113 name: regulation of microtubule polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0032271 ! regulation of protein polymerization relationship: regulates GO:0046785 ! microtubule polymerization [Term] id: GO:0031114 name: regulation of microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "regulation of microtubule disassembly" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0043244 ! regulation of protein complex disassembly relationship: regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0031115 name: negative regulation of microtubule polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization" EXACT [] synonym: "down-regulation of microtubule polymerization" EXACT [] synonym: "downregulation of microtubule polymerization" EXACT [] synonym: "inhibition of microtubule polymerization" NARROW [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032272 ! negative regulation of protein polymerization relationship: negatively_regulates GO:0046785 ! microtubule polymerization [Term] id: GO:0031116 name: positive regulation of microtubule polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "activation of microtubule polymerization" NARROW [] synonym: "stimulation of microtubule polymerization" NARROW [] synonym: "up regulation of microtubule polymerization" EXACT [] synonym: "up-regulation of microtubule polymerization" EXACT [] synonym: "upregulation of microtubule polymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032273 ! positive regulation of protein polymerization relationship: positively_regulates GO:0046785 ! microtubule polymerization [Term] id: GO:0031117 name: positive regulation of microtubule depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "activation of microtubule depolymerization" NARROW [] synonym: "microtubule destabilization" EXACT [] synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of microtubule disassembly" EXACT [] synonym: "stimulation of microtubule depolymerization" NARROW [] synonym: "up regulation of microtubule depolymerization" EXACT [] synonym: "up-regulation of microtubule depolymerization" EXACT [] synonym: "upregulation of microtubule depolymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:0043243 ! positive regulation of protein complex disassembly relationship: positively_regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0031118 name: rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule." [GOC:mah] is_a: GO:0000154 ! rRNA modification is_a: GO:0001522 ! pseudouridine synthesis [Term] id: GO:0031119 name: tRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah] is_a: GO:0001522 ! pseudouridine synthesis is_a: GO:0006400 ! tRNA modification [Term] id: GO:0031120 name: snRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an snRNA molecule." [GOC:mah] is_a: GO:0001522 ! pseudouridine synthesis is_a: GO:0040031 ! snRNA modification [Term] id: GO:0031121 name: equatorial microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell." [GOC:mah, GOC:vw] synonym: "equatorial microtubule organisation" EXACT [GOC:curators] synonym: "equatorial microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031122 name: cytoplasmic microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] synonym: "cytoplasmic microtubule organisation" EXACT [GOC:curators] synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031123 name: RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah] subset: gosubset_prok synonym: "RNA 3' end processing" EXACT [] is_a: GO:0006396 ! RNA processing [Term] id: GO:0031124 name: mRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] subset: gosubset_prok synonym: "mRNA 3' end processing" EXACT [] xref: Reactome:1252973 "mRNA 3'-end processing" xref: Reactome:1279903 "mRNA 3'-end processing" xref: Reactome:1326476 "mRNA 3'-end processing" xref: Reactome:1352590 "mRNA 3'-end processing" xref: Reactome:1372818 "mRNA 3'-end processing" xref: Reactome:1392825 "mRNA 3'-end processing" xref: Reactome:1417303 "mRNA 3'-end processing" xref: Reactome:1450393 "mRNA 3'-end processing" xref: Reactome:1470920 "mRNA 3'-end processing" xref: Reactome:1482960 "mRNA 3'-end processing" xref: Reactome:72187 "mRNA 3'-end processing" is_a: GO:0006397 ! mRNA processing is_a: GO:0031123 ! RNA 3'-end processing [Term] id: GO:0031125 name: rRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah] synonym: "rRNA 3' end processing" EXACT [] is_a: GO:0006364 ! rRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0031126 name: snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a snoRNA molecule." [GOC:mah] synonym: "snoRNA 3' end processing" EXACT [] is_a: GO:0043144 ! snoRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0031127 name: alpha(1,2)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,2)-linkage." [GOC:mah] subset: gosubset_prok is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0031128 name: developmental induction namespace: biological_process def: "Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other." [GOC:mah] is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment [Term] id: GO:0031129 name: inductive cell-cell signaling namespace: biological_process def: "Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate." [GOC:mah] synonym: "inductive cell-cell signalling" EXACT [] is_a: GO:0031128 ! developmental induction [Term] id: GO:0031130 name: creation of an inductive signal namespace: biological_process def: "The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter." [GOC:mah] is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0031131 name: reception of an inductive signal namespace: biological_process def: "The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change." [GOC:mah] is_a: GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0031132 name: serine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + NADP(+) = L-alpha-formylglycine + 2 H(+) + NADPH." [EC:1.1.1.276, RHEA:21599] synonym: "L-serine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.276] xref: EC:1.1.1.276 xref: KEGG:R06126 xref: MetaCyc:RXN0-2201 xref: RHEA:21599 xref: Wikipedia:Serine_3-dehydrogenase is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0031133 name: regulation of axon diameter namespace: biological_process def: "Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0032536 ! regulation of cell projection size is_a: GO:0050770 ! regulation of axonogenesis [Term] id: GO:0031134 name: sister chromatid biorientation namespace: biological_process def: "The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047] synonym: "chromosome biorientation" EXACT [] synonym: "sister kinetochore biorientation" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051313 ! attachment of spindle microtubules to chromosome relationship: part_of GO:0007080 ! mitotic metaphase plate congression [Term] id: GO:0031135 name: negative regulation of conjugation namespace: biological_process def: "Any process that decreases the rate of conjugation." [GOC:mah] synonym: "down regulation of conjugation" EXACT [] synonym: "down-regulation of conjugation" EXACT [] synonym: "downregulation of conjugation" EXACT [] synonym: "inhibition of conjugation" NARROW [] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0046999 ! regulation of conjugation relationship: negatively_regulates GO:0000746 ! conjugation [Term] id: GO:0031136 name: positive regulation of conjugation namespace: biological_process def: "Any process that increases the rate or frequency of conjugation." [GOC:mah] synonym: "activation of conjugation" NARROW [] synonym: "stimulation of conjugation" NARROW [] synonym: "up regulation of conjugation" EXACT [] synonym: "up-regulation of conjugation" EXACT [] synonym: "upregulation of conjugation" EXACT [] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0046999 ! regulation of conjugation relationship: positively_regulates GO:0000746 ! conjugation [Term] id: GO:0031137 name: regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the rate or frequency of conjugation with cellular fusion." [GOC:mah] is_a: GO:0046999 ! regulation of conjugation relationship: regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0031138 name: negative regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that decreases the rate or frequency of conjugation with cellular fusion." [GOC:mah] synonym: "down regulation of conjugation with cellular fusion" EXACT [] synonym: "down-regulation of conjugation with cellular fusion" EXACT [] synonym: "downregulation of conjugation with cellular fusion" EXACT [] synonym: "inhibition of conjugation with cellular fusion" NARROW [] is_a: GO:0031135 ! negative regulation of conjugation is_a: GO:0031137 ! regulation of conjugation with cellular fusion relationship: negatively_regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0031139 name: positive regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that increases the rate or frequency of conjugation with cellular fusion." [GOC:mah] synonym: "activation of conjugation with cellular fusion" NARROW [] synonym: "stimulation of conjugation with cellular fusion" NARROW [] synonym: "up regulation of conjugation with cellular fusion" EXACT [] synonym: "up-regulation of conjugation with cellular fusion" EXACT [] synonym: "upregulation of conjugation with cellular fusion" EXACT [] is_a: GO:0031136 ! positive regulation of conjugation is_a: GO:0031137 ! regulation of conjugation with cellular fusion relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0031140 name: induction of conjugation upon nutrient starvation namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients." [GOC:mah] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion [Term] id: GO:0031141 name: induction of conjugation upon carbon starvation namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion upon carbon starvation." [GOC:mah] is_a: GO:0031140 ! induction of conjugation upon nutrient starvation [Term] id: GO:0031142 name: induction of conjugation upon nitrogen starvation namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:mah] is_a: GO:0006995 ! cellular response to nitrogen starvation is_a: GO:0031140 ! induction of conjugation upon nutrient starvation [Term] id: GO:0031143 name: pseudopodium namespace: cellular_component def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir synonym: "pseudopod" EXACT [] xref: Wikipedia:Pseudopod is_a: GO:0042995 ! cell projection [Term] id: GO:0031144 name: proteasome localization namespace: biological_process def: "Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of proteasome localization" EXACT [] synonym: "proteasome localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization [Term] id: GO:0031145 name: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] xref: Reactome:1253272 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1253393 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1253394 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1253397 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:1253399 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1280208 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1280332 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1280333 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1280336 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:1280338 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1299078 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1326784 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1326910 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1326911 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1326914 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:1326916 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1352888 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1353001 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1353002 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1353005 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:1353007 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1373094 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1373197 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1373198 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1373201 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1373203 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:1393109 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1393211 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1393212 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1393215 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1393217 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:1417595 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1417707 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1417708 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1417711 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:1417713 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1450686 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1450806 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1450807 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1450811 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:1450813 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1471150 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1471217 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1471218 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1471221 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:1471223 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1483153 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1496898 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1496902 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1496903 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" xref: Reactome:1496904 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:1514291 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1514295 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1521104 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1521165 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:1526906 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:1532639 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:174048 "APC/C:Cdc20 mediated degradation of Cyclin B" xref: Reactome:174143 "APC/C-mediated degradation of cell cycle proteins" xref: Reactome:174154 "APC/C:Cdc20 mediated degradation of Securin" xref: Reactome:174178 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" xref: Reactome:174184 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0031146 name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083] synonym: "SCF-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0031147 name: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism" EXACT [] synonym: "DIF-1 metabolic process" EXACT [] synonym: "DIF-1 metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process [Term] id: GO:0031148 name: DIF-1 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis" EXACT [] synonym: "DIF-1 biosynthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0031147 ! 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process [Term] id: GO:0031149 name: sorocarp stalk cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "stalk cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0031150 ! sorocarp stalk development [Term] id: GO:0031150 name: sorocarp stalk development namespace: biological_process def: "The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048 "DictyBase paper repository", GOC:mtg_sensu, ISBN:0521583640] synonym: "sorophore development" EXACT [] synonym: "stalk development" BROAD [] synonym: "stalk formation" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0031154 ! culmination involved in sorocarp development [Term] id: GO:0031151 name: histone methyltransferase activity (H3-K79 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351] synonym: "histone lysine N-methyltransferase activity (H3-K79 specific)" EXACT [] synonym: "histone methylase activity (H3-K79 specific)" EXACT [GOC:mah] is_a: GO:0018024 ! histone-lysine N-methyltransferase activity [Term] id: GO:0031152 name: aggregation involved in sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "aggregate development involved in sorocarp development" EXACT [] synonym: "aggregation during fruiting body development" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031153 name: slug development involved in sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "migratory slug development during sorocarp development" NARROW [] synonym: "pseudoplasmodium biosynthesis" EXACT [] synonym: "pseudoplasmodium formation" EXACT [] synonym: "slug development during fruiting body development" EXACT [] synonym: "slug development during sorocarp development" RELATED [GOC:dph, GOC:tb] synonym: "standing slug development during sorocarp development" NARROW [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031154 name: culmination involved in sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "culminant development" EXACT [] synonym: "culmination during fruiting body development" EXACT [] synonym: "culmination during sorocarp development" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031155 name: regulation of fruiting body development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fruiting body development." [GOC:mah] synonym: "regulation of fruiting body formation" EXACT [] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0030582 ! fruiting body development [Term] id: GO:0031156 name: regulation of sorocarp development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:2530 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu] synonym: "regulation of fruiting body development" BROAD [] synonym: "regulation of fruiting body formation" BROAD [] is_a: GO:0031155 ! regulation of fruiting body development is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0080134 ! regulation of response to stress relationship: regulates GO:0030587 ! sorocarp development [Term] id: GO:0031157 name: regulation of aggregate size involved in sorocarp development namespace: biological_process def: "Any process that modulates the size of the aggregate formed during sorocarp formation." [dictyBase_REF:5048 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, GOC:pg] synonym: "regulation of aggregation during fruiting body biosynthesis" RELATED [] synonym: "regulation of aggregation during fruiting body formation" RELATED [] is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0031158 name: negative regulation of aggregate size involved in sorocarp development namespace: biological_process def: "Any process that decreases the size of the aggregate formed during sorocarp formation." [dictyBase_REF:5048 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, GOC:pg] synonym: "down regulation of aggregate size" EXACT [] synonym: "down-regulation of aggregate size" EXACT [] synonym: "downregulation of aggregate size" EXACT [] synonym: "inhibition of aggregate size" NARROW [] is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development [Term] id: GO:0031159 name: positive regulation of aggregate size involved in sorocarp development namespace: biological_process def: "Any process that increases the size of the aggregate formed during sorocarp formation." [dictyBase_REF:5048 "DictyBase paper repository", GOC:mah, GOC:pg] synonym: "activation of aggregate size" NARROW [] synonym: "stimulation of aggregate size" NARROW [] synonym: "up regulation of aggregate size" EXACT [] synonym: "up-regulation of aggregate size" EXACT [] synonym: "upregulation of aggregate size" EXACT [] is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development [Term] id: GO:0031160 name: spore wall namespace: cellular_component def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] synonym: "spore coat" EXACT [] is_a: GO:0005618 ! cell wall [Term] id: GO:0031161 name: phosphatidylinositol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:mah] synonym: "phosphatidylinositol breakdown" EXACT [] synonym: "phosphatidylinositol catabolism" EXACT [] synonym: "phosphatidylinositol degradation" EXACT [] synonym: "PtdIns catabolic process" EXACT [] synonym: "PtdIns catabolism" EXACT [] is_a: GO:0046475 ! glycerophospholipid catabolic process is_a: GO:0046488 ! phosphatidylinositol metabolic process [Term] id: GO:0031162 name: sulfur incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of exogenous sulfur into a metallo-sulfur cluster." [GOC:mah] synonym: "sulphur incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0006464 ! protein modification process is_a: GO:0006790 ! sulfur compound metabolic process relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly [Term] id: GO:0031163 name: metallo-sulfur cluster assembly namespace: biological_process def: "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster." [GOC:mah] subset: gosubset_prok synonym: "metallo-sulfur cluster biosynthesis" EXACT [] synonym: "metallo-sulphur cluster assembly" EXACT [] is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0031164 name: contractile vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg] synonym: "contractile vacuole membrane" EXACT [GOC:mah, GOC:pf] is_a: GO:0005774 ! vacuolar membrane is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0000331 ! contractile vacuole [Term] id: GO:0031165 name: integral to contractile vacuolar membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the contractile vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:pg] is_a: GO:0031166 ! integral to vacuolar membrane is_a: GO:0031311 ! intrinsic to contractile vacuolar membrane [Term] id: GO:0031166 name: integral to vacuolar membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031301 ! integral to organelle membrane is_a: GO:0031310 ! intrinsic to vacuolar membrane [Term] id: GO:0031167 name: rRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah] is_a: GO:0000154 ! rRNA modification is_a: GO:0001510 ! RNA methylation [Term] id: GO:0031168 name: ferrichrome metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ferrichrome metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0031169 name: ferrichrome biosynthetic process namespace: biological_process alt_id: GO:0031199 alt_id: GO:0031200 def: "The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ferrichrome anabolism" EXACT [] synonym: "ferrichrome biosynthesis" EXACT [] synonym: "ferrichrome biosynthetic process, peptide formation" NARROW [] synonym: "ferrichrome biosynthetic process, peptide modification" NARROW [] synonym: "ferrichrome formation" EXACT [] synonym: "ferrichrome synthesis" EXACT [] is_a: GO:0019539 ! siderophore biosynthetic process from hydroxamic acid is_a: GO:0031168 ! ferrichrome metabolic process [Term] id: GO:0031170 name: ferricrocin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] synonym: "ferricrocin metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0031171 name: ferricrocin biosynthetic process namespace: biological_process alt_id: GO:0031185 alt_id: GO:0031186 def: "The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] synonym: "ferricrocin anabolism" EXACT [] synonym: "ferricrocin biosynthesis" EXACT [] synonym: "ferricrocin biosynthetic process, peptide formation" NARROW [] synonym: "ferricrocin biosynthetic process, peptide modification" NARROW [] synonym: "ferricrocin formation" EXACT [] synonym: "ferricrocin synthesis" EXACT [] is_a: GO:0019290 ! siderophore biosynthetic process is_a: GO:0031170 ! ferricrocin metabolic process [Term] id: GO:0031172 name: ornithine N5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O." [MetaCyc:RXN-11128, PMID:12828635] synonym: "L-ornithine 5-monooxygenase activity" EXACT [MetaCyc:RXN-11128] xref: MetaCyc:RXN-11128 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0031173 name: otolith mineralization completed early in development namespace: biological_process def: "The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873] synonym: "otoconia mineralization" EXACT [] synonym: "otoconium mineralization" EXACT [] is_a: GO:0045299 ! otolith mineralization [Term] id: GO:0031174 name: lifelong otolith mineralization namespace: biological_process def: "The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added." [GOC:dsf, PMID:15581873] is_a: GO:0045299 ! otolith mineralization [Term] id: GO:0031175 name: neuron projection development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite development" NARROW [GOC:dph] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite outgrowth" NARROW [] is_a: GO:0030030 ! cell projection organization relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0031176 name: endo-1,4-beta-xylanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8] synonym: "1,4-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "1,4-beta-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "beta-1,4-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "beta-D-xylanase activity" EXACT [EC:3.2.1.8] synonym: "beta-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "endo-1,4-b-xylanase activity" EXACT [] synonym: "endo-1,4-beta-D-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "xylanase" BROAD [EC:3.2.1.8] xref: EC:3.2.1.8 xref: MetaCyc:3.2.1.8-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0031177 name: phosphopantetheine binding namespace: molecular_function def: "Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah] is_a: GO:0019842 ! vitamin binding is_a: GO:0072341 ! modified amino acid binding [Term] id: GO:0031179 name: peptide modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah] subset: gosubset_prok is_a: GO:0006518 ! peptide metabolic process [Term] id: GO:0031201 name: SNARE complex namespace: cellular_component def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [PMID:10872468] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part [Term] id: GO:0031203 name: posttranslational protein targeting to membrane, docking namespace: biological_process def: "The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex." [PMID:12518217, PMID:8707814] synonym: "posttranslational protein membrane targeting, docking" EXACT [] synonym: "protein docking during posttranslational protein targeting to membrane" EXACT [] synonym: "Sec-translated protein complex assembly" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006620 ! posttranslational protein targeting to membrane [Term] id: GO:0031204 name: posttranslational protein targeting to membrane, translocation namespace: biological_process def: "The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814] synonym: "posttranslational protein membrane targeting, translocation" EXACT [] synonym: "protein translocation during posttranslational protein targeting to membrane" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0006620 ! posttranslational protein targeting to membrane [Term] id: GO:0031205 name: endoplasmic reticulum Sec complex namespace: cellular_component def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:12158317, PMID:14617809] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane [Term] id: GO:0031207 name: Sec62/Sec63 complex namespace: cellular_component def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809] synonym: "ER protein translocation subcomplex " EXACT [] synonym: "Sec62/63 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0031205 ! endoplasmic reticulum Sec complex [Term] id: GO:0031208 name: POZ domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0031209 name: SCAR complex namespace: cellular_component def: "A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570] synonym: "WAVE complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031210 name: phosphatidylcholine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005543 ! phospholipid binding is_a: GO:0043169 ! cation binding is_a: GO:0043176 ! amine binding is_a: GO:0043178 ! alcohol binding is_a: GO:0050997 ! quaternary ammonium group binding [Term] id: GO:0031211 name: endoplasmic reticulum palmitoyltransferase complex namespace: cellular_component def: "A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh] is_a: GO:0002178 ! palmitoyltransferase complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0031213 name: RSF complex namespace: cellular_component def: "A chromatin remodeling complex that mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In humans, the complex is composed of the ATPase hSNF2H and the HBXAP protein (RSF-1)." [PMID:12972596] synonym: "remodeling and spacing factor complex " EXACT [] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0031214 name: biomineral tissue development namespace: biological_process def: "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." [PMID:15132736] synonym: "biomineral formation" RELATED [GOC:dph, GOC:tb] synonym: "biomineralization" EXACT [] synonym: "mineralization" EXACT [] xref: Wikipedia:Biomineralisation is_a: GO:0009888 ! tissue development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0031215 name: shell calcification namespace: biological_process def: "The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell." [GOC:mah, PMID:15132736] is_a: GO:0031214 ! biomineral tissue development [Term] id: GO:0031216 name: neopullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pullulan to panose (6-a-D-glucosylmaltose)." [EC:3.2.1.135, GOC:mlg] synonym: "pullulan 4-D-glucanohydrolase (panose-forming)" EXACT [EC:3.2.1.135] synonym: "pullulanase II activity" EXACT [] xref: EC:3.2.1.135 xref: MetaCyc:3.2.1.135-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0031217 name: glucan 1,4-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-linkages in 1,4-beta-D-glucans, to remove successive glucose units." [EC:3.2.1.74, GOC:mlg] synonym: "1,4-beta-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.74] synonym: "beta-1,4-beta-glucanase activity" EXACT [EC:3.2.1.74] synonym: "beta-1,4-glucanase activity" EXACT [] synonym: "exo-1,4-beta-D-glucosidase activity" EXACT [EC:3.2.1.74] synonym: "exo-1,4-beta-glucanase activity" EXACT [] synonym: "exo-1,4-beta-glucosidase activity" EXACT [] synonym: "exo-beta-1,4-glucanase activity" EXACT [] synonym: "exo-beta-1,4-glucosidase activity" EXACT [] synonym: "exocellulase activity" EXACT [] xref: EC:3.2.1.74 xref: MetaCyc:3.2.1.74-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0031218 name: arabinogalactan endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-galactosidic linkages in arabinogalactans." [EC:3.2.1.89, GOC:mlg] synonym: "arabinogalactan 4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.89] synonym: "arabinogalactanase activity" EXACT [] synonym: "endo-1,4-beta-galactanase activity" EXACT [] synonym: "galactanase activity" EXACT [] xref: EC:3.2.1.89 xref: MetaCyc:3.2.1.89-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0031219 name: levanase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units." [EC:3.2.1.65, GOC:mlg] synonym: "2,6-beta-D-fructan fructanohydrolase activity" EXACT [EC:3.2.1.65] synonym: "levan hydrolase activity" EXACT [] xref: EC:3.2.1.65 xref: MetaCyc:3.2.1.65-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0031220 name: maltodextrin phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846] xref: MetaCyc:RXN-9025 xref: MetaCyc:RXN0-5182 is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0031221 name: arabinan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabinan, a branched homopolymer of L-arabinose." [GOC:mlg, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "arabinan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0031222 name: arabinan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arabinan, a branched homopolymer of L-arabinose." [GOC:mlg, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "arabinan breakdown" EXACT [] synonym: "arabinan catabolism" EXACT [] synonym: "arabinan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0031221 ! arabinan metabolic process [Term] id: GO:0031223 name: auditory behavior namespace: biological_process def: "The actions or reactions of an organism in response to a sound." [GOC:rc] synonym: "auditory behaviour" EXACT [] synonym: "behavioral response to sound" EXACT [] synonym: "behavioural response to sound" EXACT [] is_a: GO:0007638 ! mechanosensory behavior [Term] id: GO:0031224 name: intrinsic to membrane namespace: cellular_component def: "Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent. subset: gosubset_prok is_a: GO:0044425 ! membrane part [Term] id: GO:0031225 name: anchored to membrane namespace: cellular_component def: "Tethered to a membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane." [GOC:mah] is_a: GO:0031224 ! intrinsic to membrane [Term] id: GO:0031226 name: intrinsic to plasma membrane namespace: cellular_component def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] subset: gosubset_prok is_a: GO:0031224 ! intrinsic to membrane is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0031227 name: intrinsic to endoplasmic reticulum membrane namespace: cellular_component def: "Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0031228 name: intrinsic to Golgi membrane namespace: cellular_component def: "Located in the Golgi membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0000139 ! Golgi membrane [Term] id: GO:0031229 name: intrinsic to nuclear inner membrane namespace: cellular_component def: "Located in the nuclear inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044453 ! nuclear membrane part relationship: part_of GO:0005637 ! nuclear inner membrane [Term] id: GO:0031230 name: intrinsic to cell outer membrane namespace: cellular_component def: "Located in the cell outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0031224 ! intrinsic to membrane is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031231 name: intrinsic to peroxisomal membrane namespace: cellular_component def: "Located in the peroxisomal membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044439 ! peroxisomal part relationship: part_of GO:0005778 ! peroxisomal membrane [Term] id: GO:0031232 name: extrinsic to external side of plasma membrane namespace: cellular_component def: "Loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah] is_a: GO:0019897 ! extrinsic to plasma membrane relationship: part_of GO:0009897 ! external side of plasma membrane [Term] id: GO:0031233 name: intrinsic to external side of plasma membrane namespace: cellular_component def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm." [GOC:mah] is_a: GO:0031226 ! intrinsic to plasma membrane relationship: part_of GO:0009897 ! external side of plasma membrane [Term] id: GO:0031234 name: extrinsic to internal side of plasma membrane namespace: cellular_component def: "Loosely bound to the surface of the plasma membrane that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah] is_a: GO:0019897 ! extrinsic to plasma membrane is_a: GO:0044424 ! intracellular part relationship: part_of GO:0009898 ! internal side of plasma membrane [Term] id: GO:0031235 name: intrinsic to internal side of plasma membrane namespace: cellular_component def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the cytoplasm." [GOC:mah] is_a: GO:0031226 ! intrinsic to plasma membrane relationship: part_of GO:0009898 ! internal side of plasma membrane [Term] id: GO:0031236 name: extrinsic to external side of plasma membrane, in periplasmic space namespace: cellular_component alt_id: GO:0031238 def: "Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0031232 ! extrinsic to external side of plasma membrane is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0030288 ! outer membrane-bounded periplasmic space [Term] id: GO:0031237 name: intrinsic to external side of plasma membrane, in periplasmic space namespace: cellular_component alt_id: GO:0031239 def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0031233 ! intrinsic to external side of plasma membrane is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0030288 ! outer membrane-bounded periplasmic space [Term] id: GO:0031240 name: external side of cell outer membrane namespace: cellular_component def: "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "external side of outer membrane" RELATED [] is_a: GO:0044425 ! membrane part is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031241 name: internal side of cell outer membrane namespace: cellular_component def: "The side of the outer membrane that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "internal side of outer membrane" EXACT [] is_a: GO:0044425 ! membrane part is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031242 name: extrinsic to external side of cell outer membrane namespace: cellular_component def: "Loosely bound to the surface of the outer membrane of the cell that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "extrinsic to external side of outer membrane" EXACT [] is_a: GO:0031244 ! extrinsic to cell outer membrane relationship: part_of GO:0031240 ! external side of cell outer membrane [Term] id: GO:0031243 name: intrinsic to external side of cell outer membrane namespace: cellular_component def: "Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the periplasm." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "intrinsic to external side of outer membrane" EXACT [] is_a: GO:0031230 ! intrinsic to cell outer membrane relationship: part_of GO:0031240 ! external side of cell outer membrane [Term] id: GO:0031244 name: extrinsic to cell outer membrane namespace: cellular_component def: "Loosely bound to one surface of the outer membrane of the cell, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0019898 ! extrinsic to membrane is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031245 name: extrinsic to internal side of cell outer membrane namespace: cellular_component def: "Loosely bound to the surface of the outer membrane of the cell that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "extrinsic to internal side of outer membrane" EXACT [] is_a: GO:0031244 ! extrinsic to cell outer membrane relationship: part_of GO:0031241 ! internal side of cell outer membrane [Term] id: GO:0031246 name: intrinsic to internal side of cell outer membrane namespace: cellular_component def: "Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the periplasm." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "intrinsic to internal side of outer membrane" EXACT [] is_a: GO:0031230 ! intrinsic to cell outer membrane relationship: part_of GO:0031241 ! internal side of cell outer membrane [Term] id: GO:0031247 name: actin rod assembly namespace: biological_process def: "The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules." [GOC:pg, PMID:14706699] synonym: "actin rod formation" RELATED [GOC:mah] is_a: GO:0007015 ! actin filament organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0031248 name: protein acetyltransferase complex namespace: cellular_component def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031249 name: denatured protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with denatured proteins." [GOC:mlg] comment: Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates. is_a: GO:0005515 ! protein binding [Term] id: GO:0031250 name: anaerobic ribonucleoside-triphosphate reductase complex namespace: cellular_component def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031251 name: PAN complex namespace: cellular_component def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670] synonym: "poly(A) nuclease complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031252 name: cell leading edge namespace: cellular_component def: "The area of a motile cell closest to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "front of cell" EXACT [] synonym: "leading edge of cell" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0031253 name: cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cell surface projection." [GOC:mah] synonym: "membrane extension" RELATED [] synonym: "membrane projection" RELATED [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0044463 ! cell projection part [Term] id: GO:0031254 name: trailing edge namespace: cellular_component def: "The area of a motile cell opposite to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "back of cell" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0031255 name: lateral part of motile cell namespace: cellular_component def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg] is_a: GO:0044464 ! cell part [Term] id: GO:0031256 name: leading edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0031257 name: trailing edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0031254 ! trailing edge [Term] id: GO:0031258 name: lamellipodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane relationship: part_of GO:0030027 ! lamellipodium [Term] id: GO:0031259 name: uropod membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah] synonym: "uropodium membrane" EXACT [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031257 ! trailing edge membrane relationship: part_of GO:0001931 ! uropod [Term] id: GO:0031260 name: pseudopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0031143 ! pseudopodium [Term] id: GO:0031261 name: DNA replication preinitiation complex namespace: cellular_component def: "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:vw, PMID:12694535, PMID:15194812] synonym: "pre-IC" EXACT [] is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0031262 name: Ndc80 complex namespace: cellular_component def: "A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore." [PMID:15509863, PMID:15661517] synonym: "Nuf2-Ndc80 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000776 ! kinetochore [Term] id: GO:0031263 name: amine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in)." [GOC:mlg] subset: gosubset_prok synonym: "amine ABC transporter" NARROW [] is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0031264 name: death-inducing signaling complex namespace: cellular_component def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] subset: goslim_pir synonym: "death-inducing signalling complex" EXACT [] synonym: "DISC" EXACT [] xref: Wikipedia:Death-inducing_signaling_complex is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0031265 name: CD95 death-inducing signaling complex namespace: cellular_component def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] synonym: "CD95 death-inducing signalling complex" EXACT [] synonym: "CD95 DISC" EXACT [] synonym: "Fas death-inducing signaling complex" EXACT [] is_a: GO:0031264 ! death-inducing signaling complex [Term] id: GO:0031266 name: TRAIL death-inducing signaling complex namespace: cellular_component def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] synonym: "TRAIL death-inducing signalling complex" EXACT [] synonym: "TRAIL DISC" EXACT [] is_a: GO:0031264 ! death-inducing signaling complex [Term] id: GO:0031267 name: small GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small monomeric GTPase." [GOC:mah] is_a: GO:0051020 ! GTPase binding [Term] id: GO:0031268 name: pseudopodium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg] synonym: "pseudopodium organisation" EXACT [GOC:curators] synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030030 ! cell projection organization [Term] id: GO:0031269 name: pseudopodium assembly namespace: biological_process def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] synonym: "pseudopodium extension" EXACT [] synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0030031 ! cell projection assembly is_a: GO:0031268 ! pseudopodium organization [Term] id: GO:0031270 name: pseudopodium retraction namespace: biological_process def: "The myosin-based contraction and retraction of the pseudopodium." [GOC:pg] is_a: GO:0031268 ! pseudopodium organization [Term] id: GO:0031271 name: lateral pseudopodium assembly namespace: biological_process def: "The extension of a pseudopodium from the lateral area of a cell." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] synonym: "lateral pseudopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031269 ! pseudopodium assembly [Term] id: GO:0031272 name: regulation of pseudopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "regulation of pseudopodium formation" RELATED [] is_a: GO:0060491 ! regulation of cell projection assembly relationship: regulates GO:0031269 ! pseudopodium assembly [Term] id: GO:0031273 name: negative regulation of pseudopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "down regulation of pseudopodium formation" RELATED [] synonym: "down-regulation of pseudopodium formation" RELATED [] synonym: "downregulation of pseudopodium formation" RELATED [] synonym: "inhibition of pseudopodium formation" NARROW [] synonym: "negative regulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0031345 ! negative regulation of cell projection organization relationship: negatively_regulates GO:0031269 ! pseudopodium assembly [Term] id: GO:0031274 name: positive regulation of pseudopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "activation of pseudopodium formation" NARROW [] synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph] synonym: "stimulation of pseudopodium formation" NARROW [] synonym: "up regulation of pseudopodium formation" RELATED [] synonym: "up-regulation of pseudopodium formation" RELATED [] synonym: "upregulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0031346 ! positive regulation of cell projection organization relationship: positively_regulates GO:0031269 ! pseudopodium assembly [Term] id: GO:0031275 name: regulation of lateral pseudopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] synonym: "regulation of lateral pseudopodium formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0031272 ! regulation of pseudopodium assembly relationship: regulates GO:0031271 ! lateral pseudopodium assembly [Term] id: GO:0031276 name: negative regulation of lateral pseudopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] synonym: "down regulation of lateral pseudopodium formation" RELATED [] synonym: "down-regulation of lateral pseudopodium formation" RELATED [] synonym: "downregulation of lateral pseudopodium formation" RELATED [] synonym: "inhibition of lateral pseudopodium formation" NARROW [] synonym: "negative regulation of lateral pseudopodium formation" RELATED [GOC:dph] is_a: GO:0031273 ! negative regulation of pseudopodium assembly is_a: GO:0031275 ! regulation of lateral pseudopodium assembly relationship: negatively_regulates GO:0031271 ! lateral pseudopodium assembly [Term] id: GO:0031277 name: positive regulation of lateral pseudopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] synonym: "activation of lateral pseudopodium formation" NARROW [] synonym: "positive regulation of lateral pseudopodium formation" RELATED [] synonym: "stimulation of lateral pseudopodium formation" NARROW [] synonym: "up regulation of lateral pseudopodium formation" RELATED [] synonym: "up-regulation of lateral pseudopodium formation" RELATED [] synonym: "upregulation of lateral pseudopodium formation" RELATED [] is_a: GO:0031274 ! positive regulation of pseudopodium assembly is_a: GO:0031275 ! regulation of lateral pseudopodium assembly relationship: positively_regulates GO:0031271 ! lateral pseudopodium assembly [Term] id: GO:0031278 name: alpha-1,2-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage." [PMID:7522655] xref: EC:2.4.1.- is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0031279 name: regulation of cyclase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclase activity." [GOC:mah] subset: gosubset_prok is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0031280 name: negative regulation of cyclase activity namespace: biological_process def: "Any process that stops or reduces the activity of a cyclase." [GOC:mah] synonym: "down regulation of cyclase activity" EXACT [] synonym: "down-regulation of cyclase activity" EXACT [] synonym: "downregulation of cyclase activity" EXACT [] synonym: "inhibition of cyclase activity" NARROW [] is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0043086 ! negative regulation of catalytic activity [Term] id: GO:0031281 name: positive regulation of cyclase activity namespace: biological_process def: "Any process that activates or increases the activity of a cyclase." [GOC:mah] synonym: "activation of cyclase activity" NARROW [] synonym: "stimulation of cyclase activity" NARROW [] synonym: "up regulation of cyclase activity" EXACT [] synonym: "up-regulation of cyclase activity" EXACT [] synonym: "upregulation of cyclase activity" EXACT [] is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0043085 ! positive regulation of catalytic activity [Term] id: GO:0031282 name: regulation of guanylate cyclase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] is_a: GO:0030826 ! regulation of cGMP biosynthetic process is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0051339 ! regulation of lyase activity [Term] id: GO:0031283 name: negative regulation of guanylate cyclase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] synonym: "down regulation of guanylate cyclase activity" EXACT [] synonym: "down-regulation of guanylate cyclase activity" EXACT [] synonym: "downregulation of guanylate cyclase activity" EXACT [] synonym: "inhibition of guanylate cyclase activity" NARROW [] is_a: GO:0031280 ! negative regulation of cyclase activity is_a: GO:0031282 ! regulation of guanylate cyclase activity is_a: GO:0051350 ! negative regulation of lyase activity [Term] id: GO:0031284 name: positive regulation of guanylate cyclase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] synonym: "activation of guanylate cyclase activity" NARROW [] synonym: "stimulation of guanylate cyclase activity" NARROW [] synonym: "up regulation of guanylate cyclase activity" EXACT [] synonym: "up-regulation of guanylate cyclase activity" EXACT [] synonym: "upregulation of guanylate cyclase activity" EXACT [] is_a: GO:0031281 ! positive regulation of cyclase activity is_a: GO:0031282 ! regulation of guanylate cyclase activity is_a: GO:0051349 ! positive regulation of lyase activity [Term] id: GO:0031285 name: regulation of sorocarp stalk cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu] synonym: "regulation of stalk cell differentiation" EXACT [] is_a: GO:0031156 ! regulation of sorocarp development is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0031149 ! sorocarp stalk cell differentiation [Term] id: GO:0031286 name: negative regulation of sorocarp stalk cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu] synonym: "down regulation of stalk cell differentiation" EXACT [] synonym: "down-regulation of stalk cell differentiation" EXACT [] synonym: "downregulation of stalk cell differentiation" EXACT [] synonym: "inhibition of stalk cell differentiation" NARROW [] synonym: "negative regulation of stalk cell differentiation" EXACT [] is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0075262 ! negative regulation of spore-bearing organ development relationship: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation [Term] id: GO:0031287 name: positive regulation of sorocarp stalk cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu] synonym: "activation of stalk cell differentiation" NARROW [] synonym: "positive regulation of stalk cell differentiation" EXACT [] synonym: "stimulation of stalk cell differentiation" NARROW [] synonym: "up regulation of stalk cell differentiation" EXACT [] synonym: "up-regulation of stalk cell differentiation" EXACT [] synonym: "upregulation of stalk cell differentiation" EXACT [] is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0075261 ! positive regulation of spore-bearing organ development relationship: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation [Term] id: GO:0031288 name: sorocarp morphogenesis namespace: biological_process def: "The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu] synonym: "fruiting body morphogenesis" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031289 name: actin phosphorylation namespace: biological_process def: "The transfer of one or more phosphate groups to an actin molecule." [GOC:mah] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0030047 ! actin modification [Term] id: GO:0031290 name: retinal ganglion cell axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs] synonym: "retinal ganglion cell axon pathfinding" EXACT [] is_a: GO:0007411 ! axon guidance [Term] id: GO:0031291 name: Ran protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0031292 name: gene conversion at mating-type locus, DNA double-strand break processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang." [GOC:mah] is_a: GO:0000729 ! DNA double-strand break processing is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0031293 name: membrane protein intracellular domain proteolysis namespace: biological_process def: "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018] synonym: "membrane protein solubilization" RELATED [] xref: Reactome:1253489 "Regulated proteolysis of p75NTR" xref: Reactome:1280427 "Regulated proteolysis of p75NTR" xref: Reactome:1299260 "Regulated proteolysis of p75NTR" xref: Reactome:1327006 "Regulated proteolysis of p75NTR" xref: Reactome:1353100 "Regulated proteolysis of p75NTR" xref: Reactome:1373288 "Regulated proteolysis of p75NTR" xref: Reactome:1417800 "Regulated proteolysis of p75NTR" xref: Reactome:1450899 "Regulated proteolysis of p75NTR" xref: Reactome:193692 "Regulated proteolysis of p75NTR" is_a: GO:0033619 ! membrane protein proteolysis [Term] id: GO:0031294 name: lymphocyte costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "lymphocyte co-stimulation" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0031295 name: T cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "T cell co-stimulation" EXACT [] synonym: "T lymphocyte costimulation" EXACT [] synonym: "T-cell co-stimulation" EXACT [] synonym: "T-cell costimulation" EXACT [] synonym: "T-lymphocyte costimulation" EXACT [] xref: Reactome:1253513 "CD28 co-stimulation" xref: Reactome:1253514 "Costimulation by the CD28 family" xref: Reactome:1280452 "CD28 co-stimulation" xref: Reactome:1280453 "Costimulation by the CD28 family" xref: Reactome:1299430 "CD28 co-stimulation" xref: Reactome:1299431 "Costimulation by the CD28 family" xref: Reactome:1327030 "CD28 co-stimulation" xref: Reactome:1327031 "Costimulation by the CD28 family" xref: Reactome:1353124 "CD28 co-stimulation" xref: Reactome:1353125 "Costimulation by the CD28 family" xref: Reactome:1373454 "CD28 co-stimulation" xref: Reactome:1373455 "Costimulation by the CD28 family" xref: Reactome:1393326 "CD28 co-stimulation" xref: Reactome:1393327 "Costimulation by the CD28 family" xref: Reactome:1417824 "CD28 co-stimulation" xref: Reactome:1417825 "Costimulation by the CD28 family" xref: Reactome:1451070 "CD28 co-stimulation" xref: Reactome:1451071 "Costimulation by the CD28 family" xref: Reactome:1471302 "CD28 co-stimulation" xref: Reactome:1471303 "Costimulation by the CD28 family" xref: Reactome:1483275 "CD28 co-stimulation" xref: Reactome:1483276 "Costimulation by the CD28 family" xref: Reactome:1521203 "CD28 co-stimulation" xref: Reactome:1521204 "Costimulation by the CD28 family" xref: Reactome:1527002 "CD28 co-stimulation" xref: Reactome:1527003 "Costimulation by the CD28 family" xref: Reactome:1532739 "CD28 co-stimulation" xref: Reactome:1532740 "Costimulation by the CD28 family" xref: Reactome:388841 "Costimulation by the CD28 family" xref: Reactome:389356 "CD28 co-stimulation" is_a: GO:0031294 ! lymphocyte costimulation is_a: GO:0050870 ! positive regulation of T cell activation [Term] id: GO:0031296 name: B cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "B cell co-stimulation " EXACT [] synonym: "B lymphocyte co-stimulation" EXACT [] synonym: "B lymphocyte costimulation" EXACT [] synonym: "B-cell co-stimulation" EXACT [] synonym: "B-cell costimulation" EXACT [] synonym: "B-lymphocyte co-stimulation" EXACT [] synonym: "B-lymphocyte costimulation" EXACT [] is_a: GO:0031294 ! lymphocyte costimulation is_a: GO:0050871 ! positive regulation of B cell activation [Term] id: GO:0031297 name: replication fork processing namespace: biological_process def: "The process in which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted." [PMID:11459955, PMID:15367656, PMID:17660542] synonym: "collapsed replication fork processing" EXACT [] synonym: "recovery from replication fork arrest" EXACT [] synonym: "recovery from replication fork stalling" EXACT [] is_a: GO:0006974 ! response to DNA damage stimulus is_a: GO:0045005 ! maintenance of fidelity involved in DNA-dependent DNA replication [Term] id: GO:0031298 name: replication fork protection complex namespace: cellular_component def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656] synonym: "replisome progression complex" EXACT [GOC:vw] synonym: "Swi1-Swi3 complex" NARROW [] synonym: "TIMELESS-TIPIN complex" NARROW [GOC:mah, GOC:vw] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043596 ! nuclear replication fork [Term] id: GO:0031299 name: taurine-pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde." [EC:2.6.1.77, RHEA:10423] synonym: "taurine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.77] synonym: "Tpa" RELATED [EC:2.6.1.77] xref: EC:2.6.1.77 xref: KEGG:R05652 xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN xref: RHEA:10423 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0031300 name: intrinsic to organelle membrane namespace: cellular_component def: "Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031224 ! intrinsic to membrane is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0031090 ! organelle membrane [Term] id: GO:0031301 name: integral to organelle membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0016021 ! integral to membrane is_a: GO:0031300 ! intrinsic to organelle membrane [Term] id: GO:0031302 name: intrinsic to endosome membrane namespace: cellular_component def: "Located in the endosome membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0031303 name: integral to endosome membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the endosome membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031301 ! integral to organelle membrane is_a: GO:0031302 ! intrinsic to endosome membrane [Term] id: GO:0031304 name: intrinsic to mitochondrial inner membrane namespace: cellular_component def: "Located in the mitochondrial inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0031305 name: integral to mitochondrial inner membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031304 ! intrinsic to mitochondrial inner membrane is_a: GO:0032592 ! integral to mitochondrial membrane [Term] id: GO:0031306 name: intrinsic to mitochondrial outer membrane namespace: cellular_component def: "Located in the mitochondrial outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0031307 name: integral to mitochondrial outer membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031306 ! intrinsic to mitochondrial outer membrane is_a: GO:0032592 ! integral to mitochondrial membrane [Term] id: GO:0031308 name: intrinsic to nuclear outer membrane namespace: cellular_component def: "Located in the nuclear outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044453 ! nuclear membrane part relationship: part_of GO:0005640 ! nuclear outer membrane [Term] id: GO:0031309 name: integral to nuclear outer membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031301 ! integral to organelle membrane is_a: GO:0031308 ! intrinsic to nuclear outer membrane [Term] id: GO:0031310 name: intrinsic to vacuolar membrane namespace: cellular_component def: "Located in the vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0031311 name: intrinsic to contractile vacuolar membrane namespace: cellular_component def: "Located in the contractile vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031310 ! intrinsic to vacuolar membrane is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0031164 ! contractile vacuolar membrane [Term] id: GO:0031312 name: extrinsic to organelle membrane namespace: cellular_component def: "Loosely bound to one surface of an organelle membrane, but not integrated into the hydrophobic region." [GOC:mah] is_a: GO:0019898 ! extrinsic to membrane is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0031090 ! organelle membrane [Term] id: GO:0031313 name: extrinsic to endosome membrane namespace: cellular_component def: "Loosely bound to one surface of the endosome membrane, but not integrated into the hydrophobic region." [GOC:mah] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0031314 name: extrinsic to mitochondrial inner membrane namespace: cellular_component def: "Loosely bound to one surface of the mitochondrial inner membrane, but not integrated into the hydrophobic region." [GOC:mah] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0031315 name: extrinsic to mitochondrial outer membrane namespace: cellular_component def: "Loosely bound to one surface of the mitochondrial outer membrane, but not integrated into the hydrophobic region." [GOC:mah] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044455 ! mitochondrial membrane part [Term] id: GO:0031316 name: extrinsic to nuclear outer membrane namespace: cellular_component def: "Loosely bound to one surface of the nuclear outer membrane, but not integrated into the hydrophobic region." [GOC:mah] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044453 ! nuclear membrane part relationship: part_of GO:0005640 ! nuclear outer membrane [Term] id: GO:0031317 name: tripartite ATP-independent periplasmic transporter complex namespace: cellular_component def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients." [GOC:mlg] subset: gosubset_prok synonym: "TRAP transporter complex" EXACT [] synonym: "TRAP-T transporter complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0031318 name: detection of folic acid namespace: biological_process def: "The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal." [GOC:pg] synonym: "detection of folate" EXACT [] synonym: "folate detection" EXACT [] synonym: "folate sensing" EXACT [] synonym: "folic acid detection" EXACT [] synonym: "folic acid sensing" EXACT [] is_a: GO:0009594 ! detection of nutrient is_a: GO:0051593 ! response to folic acid [Term] id: GO:0031319 name: detection of cAMP namespace: biological_process def: "The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP." [GOC:pg] synonym: "3',5'-cAMP detection" EXACT [] synonym: "3',5'-cAMP sensing" EXACT [] synonym: "cAMP detection" EXACT [] synonym: "cAMP sensing" EXACT [] synonym: "cyclic AMP detection" EXACT [] synonym: "detection of 3',5' cAMP" EXACT [] synonym: "detection of 3',5'-cAMP" EXACT [] synonym: "detection of adenosine 3',5'-cyclophosphate" EXACT [] synonym: "detection of cyclic AMP" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051591 ! response to cAMP [Term] id: GO:0031320 name: hexitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [GOC:mah] subset: gosubset_prok is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0031321 name: ascospore-type prospore formation namespace: biological_process def: "During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane." [GOC:mah, PMID:14702385] synonym: "forespore formation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030437 ! ascospore formation [Term] id: GO:0031322 name: ascospore-type prospore-specific spindle pole body remodeling namespace: biological_process def: "A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385] synonym: "ascospore-type prospore-specific spindle pole body modification" RELATED [GOC:vw] synonym: "ascospore-type prospore-specific spindle pole body remodelling" EXACT [GOC:mah] synonym: "forespore specific spindle pole body remodeling" EXACT [] synonym: "forespore-specific spindle pole body remodeling" EXACT [] synonym: "prospore-specific spindle pole body remodeling" EXACT [] synonym: "sporulation-specific spindle pole body remodeling" EXACT [] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051300 ! spindle pole body organization relationship: part_of GO:0031321 ! ascospore-type prospore formation [Term] id: GO:0031323 name: regulation of cellular metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] subset: gosubset_prok synonym: "regulation of cellular metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031324 name: negative regulation of cellular metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cellular metabolic process" EXACT [] synonym: "down-regulation of cellular metabolic process" EXACT [] synonym: "downregulation of cellular metabolic process" EXACT [] synonym: "inhibition of cellular metabolic process" NARROW [] synonym: "negative regulation of cellular metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031325 name: positive regulation of cellular metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] subset: gosubset_prok synonym: "activation of cellular metabolic process" NARROW [] synonym: "positive regulation of cellular metabolism" EXACT [] synonym: "stimulation of cellular metabolic process" NARROW [] synonym: "up regulation of cellular metabolic process" EXACT [] synonym: "up-regulation of cellular metabolic process" EXACT [] synonym: "upregulation of cellular metabolic process" EXACT [] xref: Reactome:1253339 "ChREBP activates metabolic gene expression" xref: Reactome:1280277 "ChREBP activates metabolic gene expression" xref: Reactome:1299131 "ChREBP activates metabolic gene expression" xref: Reactome:1326855 "ChREBP activates metabolic gene expression" xref: Reactome:1352947 "ChREBP activates metabolic gene expression" xref: Reactome:1373151 "ChREBP activates metabolic gene expression" xref: Reactome:1393167 "ChREBP activates metabolic gene expression" xref: Reactome:1417656 "ChREBP activates metabolic gene expression" xref: Reactome:1450756 "ChREBP activates metabolic gene expression" xref: Reactome:1471194 "ChREBP activates metabolic gene expression" xref: Reactome:1483191 "ChREBP activates metabolic gene expression" xref: Reactome:1496883 "ChREBP activates metabolic gene expression" xref: Reactome:1514276 "ChREBP activates metabolic gene expression" xref: Reactome:1521141 "ChREBP activates metabolic gene expression" xref: Reactome:1526896 "ChREBP activates metabolic gene expression" xref: Reactome:1532625 "ChREBP activates metabolic gene expression" xref: Reactome:1536067 "ChREBP activates metabolic gene expression" xref: Reactome:1538038 "ChREBP activates metabolic gene expression" xref: Reactome:1539321 "ChREBP activates metabolic gene expression" xref: Reactome:1540333 "ChREBP activates metabolic gene expression" xref: Reactome:163765 "ChREBP activates metabolic gene expression" is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031326 name: regulation of cellular biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "regulation of cellular anabolism" EXACT [] synonym: "regulation of cellular biosynthesis" EXACT [] synonym: "regulation of cellular formation" EXACT [] synonym: "regulation of cellular synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031327 name: negative regulation of cellular biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cellular biosynthetic process" EXACT [] synonym: "down-regulation of cellular biosynthetic process" EXACT [] synonym: "downregulation of cellular biosynthetic process" EXACT [] synonym: "inhibition of cellular biosynthetic process" NARROW [] synonym: "negative regulation of cellular anabolism" EXACT [] synonym: "negative regulation of cellular biosynthesis" EXACT [] synonym: "negative regulation of cellular formation" EXACT [] synonym: "negative regulation of cellular synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031328 name: positive regulation of cellular biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "activation of cellular biosynthetic process" NARROW [] synonym: "positive regulation of cellular anabolism" EXACT [] synonym: "positive regulation of cellular biosynthesis" EXACT [] synonym: "positive regulation of cellular formation" EXACT [] synonym: "positive regulation of cellular synthesis" EXACT [] synonym: "stimulation of cellular biosynthetic process" NARROW [] synonym: "up regulation of cellular biosynthetic process" EXACT [] synonym: "up-regulation of cellular biosynthetic process" EXACT [] synonym: "upregulation of cellular biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: positively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031329 name: regulation of cellular catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "regulation of cellular breakdown" EXACT [] synonym: "regulation of cellular catabolism" EXACT [] synonym: "regulation of cellular degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031330 name: negative regulation of cellular catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cellular catabolic process" EXACT [] synonym: "down-regulation of cellular catabolic process" EXACT [] synonym: "downregulation of cellular catabolic process" EXACT [] synonym: "inhibition of cellular catabolic process" NARROW [] synonym: "negative regulation of cellular breakdown" EXACT [] synonym: "negative regulation of cellular catabolism" EXACT [] synonym: "negative regulation of cellular degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process relationship: negatively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031331 name: positive regulation of cellular catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "activation of cellular catabolic process" NARROW [] synonym: "positive regulation of cellular breakdown" EXACT [] synonym: "positive regulation of cellular catabolism" EXACT [] synonym: "positive regulation of cellular degradation" EXACT [] synonym: "stimulation of cellular catabolic process" NARROW [] synonym: "up regulation of cellular catabolic process" EXACT [] synonym: "up-regulation of cellular catabolic process" EXACT [] synonym: "upregulation of cellular catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process relationship: positively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031332 name: RNAi effector complex namespace: cellular_component def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433] subset: goslim_pir is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0031333 name: negative regulation of protein complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] subset: gosubset_prok synonym: "down regulation of protein complex assembly" EXACT [] synonym: "down-regulation of protein complex assembly" EXACT [] synonym: "downregulation of protein complex assembly" EXACT [] synonym: "inhibition of protein complex assembly" NARROW [] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0006461 ! protein complex assembly [Term] id: GO:0031334 name: positive regulation of protein complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] subset: gosubset_prok synonym: "activation of protein complex assembly" NARROW [] synonym: "stimulation of protein complex assembly" NARROW [] synonym: "up regulation of protein complex assembly" EXACT [] synonym: "up-regulation of protein complex assembly" EXACT [] synonym: "upregulation of protein complex assembly" EXACT [] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0006461 ! protein complex assembly [Term] id: GO:0031335 name: regulation of sulfur amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] subset: gosubset_prok synonym: "regulation of sulfur amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process relationship: regulates GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0031336 name: negative regulation of sulfur amino acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] subset: gosubset_prok synonym: "down regulation of sulfur amino acid metabolic process" EXACT [] synonym: "down-regulation of sulfur amino acid metabolic process" EXACT [] synonym: "downregulation of sulfur amino acid metabolic process" EXACT [] synonym: "inhibition of sulfur amino acid metabolic process" NARROW [] synonym: "negative regulation of sulfur amino acid metabolism" EXACT [] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process relationship: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0031337 name: positive regulation of sulfur amino acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] subset: gosubset_prok synonym: "activation of sulfur amino acid metabolic process" NARROW [] synonym: "positive regulation of sulfur amino acid metabolism" EXACT [] synonym: "stimulation of sulfur amino acid metabolic process" NARROW [] synonym: "up regulation of sulfur amino acid metabolic process" EXACT [] synonym: "up-regulation of sulfur amino acid metabolic process" EXACT [] synonym: "upregulation of sulfur amino acid metabolic process" EXACT [] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process relationship: positively_regulates GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0031338 name: regulation of vesicle fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031339 name: negative regulation of vesicle fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "down regulation of vesicle fusion" EXACT [] synonym: "down-regulation of vesicle fusion" EXACT [] synonym: "downregulation of vesicle fusion" EXACT [] synonym: "inhibition of vesicle fusion" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031340 name: positive regulation of vesicle fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "activation of vesicle fusion" NARROW [] synonym: "stimulation of vesicle fusion" NARROW [] synonym: "up regulation of vesicle fusion" EXACT [] synonym: "up-regulation of vesicle fusion" EXACT [] synonym: "upregulation of vesicle fusion" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031341 name: regulation of cell killing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0001906 ! cell killing [Term] id: GO:0031342 name: negative regulation of cell killing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." [GOC:mah] synonym: "down regulation of cell killing" EXACT [] synonym: "down-regulation of cell killing" EXACT [] synonym: "downregulation of cell killing" EXACT [] synonym: "inhibition of cell killing" NARROW [] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0001906 ! cell killing [Term] id: GO:0031343 name: positive regulation of cell killing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah] synonym: "activation of cell killing" NARROW [] synonym: "stimulation of cell killing" NARROW [] synonym: "up regulation of cell killing" EXACT [] synonym: "up-regulation of cell killing" EXACT [] synonym: "upregulation of cell killing" EXACT [] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0001906 ! cell killing [Term] id: GO:0031344 name: regulation of cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] subset: gosubset_prok synonym: "regulation of cell projection organisation" EXACT [GOC:curators] synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0030030 ! cell projection organization [Term] id: GO:0031345 name: negative regulation of cell projection organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "down regulation of cell projection organization" EXACT [GOC:mah] synonym: "down-regulation of cell projection organization" EXACT [] synonym: "downregulation of cell projection organization" EXACT [] synonym: "inhibition of cell projection organization" NARROW [] synonym: "negative regulation of cell projection organisation" EXACT [GOC:curators] synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031346 name: positive regulation of cell projection organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "activation of cell projection organization" NARROW [] synonym: "positive regulation of cell projection organisation" EXACT [GOC:curators] synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell projection organization" NARROW [] synonym: "up regulation of cell projection organization" EXACT [] synonym: "up-regulation of cell projection organization" EXACT [] synonym: "upregulation of cell projection organization" EXACT [] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031347 name: regulation of defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] is_a: GO:0080134 ! regulation of response to stress relationship: regulates GO:0006952 ! defense response [Term] id: GO:0031348 name: negative regulation of defense response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah] synonym: "down regulation of defense response" EXACT [] synonym: "down-regulation of defense response" EXACT [] synonym: "downregulation of defense response" EXACT [] synonym: "inhibition of defense response" NARROW [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0006952 ! defense response [Term] id: GO:0031349 name: positive regulation of defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] synonym: "activation of defense response" NARROW [] synonym: "stimulation of defense response" NARROW [] synonym: "up regulation of defense response" EXACT [] synonym: "up-regulation of defense response" EXACT [] synonym: "upregulation of defense response" EXACT [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0006952 ! defense response [Term] id: GO:0031350 name: intrinsic to plastid membrane namespace: cellular_component def: "Located in a plastid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031300 ! intrinsic to organelle membrane is_a: GO:0044435 ! plastid part relationship: part_of GO:0042170 ! plastid membrane [Term] id: GO:0031351 name: integral to plastid membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a plastid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031301 ! integral to organelle membrane is_a: GO:0044435 ! plastid part relationship: part_of GO:0042170 ! plastid membrane [Term] id: GO:0031352 name: intrinsic to plastid inner membrane namespace: cellular_component def: "Located in a plastid inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031350 ! intrinsic to plastid membrane relationship: part_of GO:0009528 ! plastid inner membrane [Term] id: GO:0031353 name: integral to plastid inner membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a plastid inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031351 ! integral to plastid membrane relationship: part_of GO:0009528 ! plastid inner membrane [Term] id: GO:0031354 name: intrinsic to plastid outer membrane namespace: cellular_component def: "Located in a plastid outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031350 ! intrinsic to plastid membrane relationship: part_of GO:0009527 ! plastid outer membrane [Term] id: GO:0031355 name: integral to plastid outer membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a plastid outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031351 ! integral to plastid membrane relationship: part_of GO:0009527 ! plastid outer membrane [Term] id: GO:0031356 name: intrinsic to chloroplast inner membrane namespace: cellular_component def: "Located in the chloroplast inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031352 ! intrinsic to plastid inner membrane is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009706 ! chloroplast inner membrane [Term] id: GO:0031357 name: integral to chloroplast inner membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031353 ! integral to plastid inner membrane is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009706 ! chloroplast inner membrane [Term] id: GO:0031358 name: intrinsic to chloroplast outer membrane namespace: cellular_component def: "Located in the chloroplast outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031354 ! intrinsic to plastid outer membrane is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0031359 name: integral to chloroplast outer membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031355 ! integral to plastid outer membrane is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0031360 name: intrinsic to thylakoid membrane namespace: cellular_component def: "Located in a thylakoid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031224 ! intrinsic to membrane is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0031361 name: integral to thylakoid membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0016021 ! integral to membrane is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0031362 name: anchored to external side of plasma membrane namespace: cellular_component def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah] is_a: GO:0031233 ! intrinsic to external side of plasma membrane is_a: GO:0046658 ! anchored to plasma membrane [Term] id: GO:0031363 name: N-terminal protein amino acid deamination namespace: biological_process def: "The removal of an amino group from the N-terminal amino acid residue of a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0031364 name: N-terminal protein amino acid deamination, from side chain namespace: biological_process def: "The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein." [GOC:mah] is_a: GO:0031363 ! N-terminal protein amino acid deamination [Term] id: GO:0031365 name: N-terminal protein amino acid modification namespace: biological_process alt_id: GO:0018409 def: "The alteration of the N-terminal amino acid residue in a protein." [GOC:mah] subset: gosubset_prok synonym: "peptide or protein amino-terminal blocking" RELATED [] synonym: "peptide/protein amino-terminal blocking" RELATED [] is_a: GO:0006464 ! protein modification process [Term] id: GO:0031366 name: N-terminal peptidyl-asparagine deamination namespace: biological_process def: "The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein." [GOC:bf, GOC:mah] is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain [Term] id: GO:0031367 name: N-terminal peptidyl-glutamine deamination namespace: biological_process def: "The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein." [GOC:mah] is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain [Term] id: GO:0031368 name: Pro-X metallocarboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [EC:3.4.17.16, GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase P activity" NARROW [EC:3.4.17.16] synonym: "membrane Pro-X carboxypeptidase activity" NARROW [EC:3.4.17.16] synonym: "membrane Pro-Xaa carboxypeptidase" NARROW [] synonym: "microsomal carboxypeptidase activity" NARROW [EC:3.4.17.16] xref: EC:3.4.17.16 is_obsolete: true replaced_by: GO:0004181 replaced_by: GO:0008233 [Term] id: GO:0031369 name: translation initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0031370 name: eukaryotic initiation factor 4G binding namespace: molecular_function def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] synonym: "eIF4G binding" EXACT [] is_a: GO:0031369 ! translation initiation factor binding [Term] id: GO:0031371 name: ubiquitin conjugating enzyme complex namespace: cellular_component def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah] subset: goslim_pir synonym: "E2 complex" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031372 name: UBC13-MMS2 complex namespace: cellular_component def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p." [GOC:mah, PMID:15772086] is_a: GO:0031371 ! ubiquitin conjugating enzyme complex [Term] id: GO:0031375 name: type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] comment: Type II refers to the type of fatty acid synthase. Type I is in a complex, type II is not. synonym: "type II FAS" EXACT [] synonym: "type II FAS complex" EXACT [] synonym: "type II fatty acid synthase" EXACT [] is_obsolete: true [Term] id: GO:0031376 name: cytosolic type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] synonym: "cytosolic type II FAS complex" EXACT [] is_obsolete: true [Term] id: GO:0031377 name: mitochondrial type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] comment: Obsoleted because type II fatty acid synthases are not complexes synonym: "mitochondrial type II FAS complex" EXACT [] is_obsolete: true [Term] id: GO:0031378 name: plastid type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] comment: Obsoleted because type II fatty acid synthase is not a complex. synonym: "plastid type II FAS complex" EXACT [] is_obsolete: true [Term] id: GO:0031379 name: RNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah] is_a: GO:0030880 ! RNA polymerase complex [Term] id: GO:0031380 name: nuclear RNA-directed RNA polymerase complex namespace: cellular_component def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976] synonym: "Rdr1 complex" NARROW [] synonym: "RDRC" EXACT [] is_a: GO:0031379 ! RNA-directed RNA polymerase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0031381 name: viral RNA-directed RNA polymerase complex namespace: cellular_component def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301] is_a: GO:0031379 ! RNA-directed RNA polymerase complex [Term] id: GO:0031382 name: mating projection assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi." [GOC:mah, PMID:14734532] synonym: "mating projection biogenesis" RELATED [GOC:mah] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0030031 ! cell projection assembly is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion [Term] id: GO:0031383 name: regulation of mating projection assembly namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi." [PMID:14734532] synonym: "regulation of mating projection biogenesis" RELATED [GOC:mah] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0031137 ! regulation of conjugation with cellular fusion is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0060491 ! regulation of cell projection assembly is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0031382 ! mating projection assembly [Term] id: GO:0031384 name: regulation of initiation of mating projection growth namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi." [PMID:14734532] is_a: GO:0031383 ! regulation of mating projection assembly [Term] id: GO:0031385 name: regulation of termination of mating projection growth namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi." [PMID:14734532] is_a: GO:0031383 ! regulation of mating projection assembly [Term] id: GO:0031386 name: protein tag namespace: molecular_function def: "Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators] subset: goslim_pir synonym: "covalent modifier" RELATED [GOC:vw] synonym: "protein tagging activity" RELATED [] synonym: "ubiquitin" RELATED [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0031387 name: MPF complex namespace: cellular_component def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex [Term] id: GO:0031388 name: organic acid phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into an organic acid." [GOC:mah] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0016310 ! phosphorylation [Term] id: GO:0031389 name: Rad17 RFC-like complex namespace: cellular_component def: "A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842] synonym: "Rad17-RFC" EXACT [] synonym: "Rad17-RLC" EXACT [] synonym: "Rad24p RFC-like complex" EXACT [] synonym: "RFC (Rad17)" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0031390 name: Ctf18 RFC-like complex namespace: cellular_component def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842] synonym: "Ctf18-RFC" EXACT [] synonym: "Ctf18-RLC" EXACT [] synonym: "RFC (Ctf18)" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0031391 name: Elg1 RFC-like complex namespace: cellular_component def: "A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842] synonym: "Elg1-RFC" EXACT [] synonym: "Elg1-RLC" EXACT [] synonym: "RFC (Elg1)" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0031392 name: regulation of prostaglandin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] synonym: "regulation of prostaglandin anabolism" EXACT [] synonym: "regulation of prostaglandin biosynthesis" EXACT [] synonym: "regulation of prostaglandin formation" EXACT [] synonym: "regulation of prostaglandin synthesis" EXACT [] is_a: GO:0042304 ! regulation of fatty acid biosynthetic process relationship: regulates GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0031393 name: negative regulation of prostaglandin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] synonym: "down regulation of prostaglandin biosynthetic process" EXACT [] synonym: "down-regulation of prostaglandin biosynthetic process" EXACT [] synonym: "downregulation of prostaglandin biosynthetic process" EXACT [] synonym: "inhibition of prostaglandin biosynthetic process" NARROW [] synonym: "negative regulation of prostaglandin anabolism" EXACT [] synonym: "negative regulation of prostaglandin biosynthesis" EXACT [] synonym: "negative regulation of prostaglandin formation" EXACT [] synonym: "negative regulation of prostaglandin synthesis" EXACT [] is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process relationship: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0031394 name: positive regulation of prostaglandin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] synonym: "activation of prostaglandin biosynthetic process" NARROW [] synonym: "positive regulation of prostaglandin anabolism" EXACT [] synonym: "positive regulation of prostaglandin biosynthesis" EXACT [] synonym: "positive regulation of prostaglandin formation" EXACT [] synonym: "positive regulation of prostaglandin synthesis" EXACT [] synonym: "stimulation of prostaglandin biosynthetic process" NARROW [] synonym: "up regulation of prostaglandin biosynthetic process" EXACT [] synonym: "up-regulation of prostaglandin biosynthetic process" EXACT [] synonym: "upregulation of prostaglandin biosynthetic process" EXACT [] is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process relationship: positively_regulates GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0031395 name: bursicon neuropeptide hormone complex namespace: cellular_component def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0031396 name: regulation of protein ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0016567 ! protein ubiquitination [Term] id: GO:0031397 name: negative regulation of protein ubiquitination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] synonym: "down regulation of protein ubiquitination" EXACT [] synonym: "down-regulation of protein ubiquitination" EXACT [] synonym: "downregulation of protein ubiquitination" EXACT [] synonym: "inhibition of protein ubiquitination" NARROW [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:0031400 ! negative regulation of protein modification process relationship: negatively_regulates GO:0016567 ! protein ubiquitination [Term] id: GO:0031398 name: positive regulation of protein ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] synonym: "activation of protein ubiquitination" NARROW [] synonym: "stimulation of protein ubiquitination" NARROW [] synonym: "up regulation of protein ubiquitination" EXACT [] synonym: "up-regulation of protein ubiquitination" EXACT [] synonym: "upregulation of protein ubiquitination" EXACT [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:0031401 ! positive regulation of protein modification process relationship: positively_regulates GO:0016567 ! protein ubiquitination [Term] id: GO:0031399 name: regulation of protein modification process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: gosubset_prok is_a: GO:0032268 ! regulation of cellular protein metabolic process relationship: regulates GO:0006464 ! protein modification process [Term] id: GO:0031400 name: negative regulation of protein modification process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "down regulation of protein modification" EXACT [] synonym: "down-regulation of protein modification" EXACT [] synonym: "downregulation of protein modification" EXACT [] synonym: "inhibition of protein modification" NARROW [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032269 ! negative regulation of cellular protein metabolic process relationship: negatively_regulates GO:0006464 ! protein modification process [Term] id: GO:0031401 name: positive regulation of protein modification process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "activation of protein modification" NARROW [] synonym: "stimulation of protein modification" NARROW [] synonym: "up regulation of protein modification" EXACT [] synonym: "up-regulation of protein modification" EXACT [] synonym: "upregulation of protein modification" EXACT [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process relationship: positively_regulates GO:0006464 ! protein modification process [Term] id: GO:0031402 name: sodium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with sodium ions (Na+)." [GOC:mah] subset: gosubset_prok is_a: GO:0031420 ! alkali metal ion binding [Term] id: GO:0031403 name: lithium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with lithium ions (Li+)." [GOC:mah] subset: gosubset_prok is_a: GO:0031420 ! alkali metal ion binding [Term] id: GO:0031404 name: chloride ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with chloride ions (Cl-)." [GOC:mah] subset: gosubset_prok synonym: "chloride binding" EXACT [] is_a: GO:0043168 ! anion binding [Term] id: GO:0031405 name: lipoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0031406 name: carboxylic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0031407 name: oxylipin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] subset: gosubset_prok synonym: "oxylipin metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0031408 name: oxylipin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] synonym: "oxylipin anabolism" EXACT [] synonym: "oxylipin biosynthesis" EXACT [] synonym: "oxylipin formation" EXACT [] synonym: "oxylipin synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0031407 ! oxylipin metabolic process [Term] id: GO:0031409 name: pigment binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component def: "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] subset: gosubset_prok xref: NIF_Subcellular:sao180601769 is_a: GO:0031982 ! vesicle is_a: GO:0043229 ! intracellular organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031411 name: gas vesicle namespace: cellular_component def: "A hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content aquatic microbes are able to perform vertical migrations." [PMID:8177173] subset: gosubset_prok is_a: GO:0031410 ! cytoplasmic vesicle is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0031412 name: gas vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps." [GOC:mah] synonym: "gas vesicle biosynthesis" NARROW [GOC:mah] synonym: "gas vesicle formation" NARROW [GOC:mah] synonym: "gas vesicle organisation" EXACT [GOC:curators] synonym: "gas vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization [Term] id: GO:0031413 name: regulation of buoyancy namespace: biological_process def: "Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases." [GOC:mah, PATO:0001420] synonym: "buoyancy regulation" EXACT [] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0031414 name: N-terminal protein acetyltransferase complex namespace: cellular_component def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah] synonym: "NAT complex" EXACT [] is_a: GO:0031248 ! protein acetyltransferase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031415 name: NatA complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471] synonym: "N-terminal acetyltransferase A complex" EXACT [] is_a: GO:0031414 ! N-terminal protein acetyltransferase complex [Term] id: GO:0031416 name: NatB complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471] synonym: "N-terminal acetyltransferase B complex" EXACT [] is_a: GO:0031414 ! N-terminal protein acetyltransferase complex [Term] id: GO:0031417 name: NatC complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471] synonym: "N-terminal acetyltransferase C complex" EXACT [] is_a: GO:0031414 ! N-terminal protein acetyltransferase complex [Term] id: GO:0031418 name: L-ascorbic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] synonym: "L-ascorbate binding" EXACT [] synonym: "vitamin C binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0031419 name: cobalamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] synonym: "vitamin B12 binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0046906 ! tetrapyrrole binding [Term] id: GO:0031420 name: alkali metal ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah] subset: gosubset_prok is_a: GO:0046872 ! metal ion binding [Term] id: GO:0031421 name: invertasome namespace: cellular_component def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277] is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031422 name: RecQ helicase-Topo III complex namespace: cellular_component def: "A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human." [PMID:15889139] synonym: "Sgs1-Top3 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0031423 name: hexon binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hexon, the major protein component of the icosahedral capsid of an adenovirus." [GOC:mah, PMID:12915569] is_a: GO:0005515 ! protein binding [Term] id: GO:0031424 name: keratinization namespace: biological_process def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0030216 ! keratinocyte differentiation [Term] id: GO:0031425 name: chloroplast RNA processing namespace: biological_process def: "The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules." [GOC:mah] is_a: GO:0006396 ! RNA processing [Term] id: GO:0031426 name: polycistronic mRNA processing namespace: biological_process def: "The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules." [GOC:mah] is_a: GO:0006397 ! mRNA processing [Term] id: GO:0031427 name: response to methotrexate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0031428 name: box C/D snoRNP complex namespace: cellular_component def: "A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type that can carry out ribose-2'-O-methylation of target RNAs." [ISBN:0879695897, PMID:17284456] synonym: "box C/D snoRNP ribose 2'-O methylase complex" EXACT [PMID:17284456] synonym: "box C/D snoRNP ribose-2'-O-methyltransferase complex" EXACT [PMID:17284456] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0031429 name: box H/ACA snoRNP complex namespace: cellular_component def: "A box H/ACA RNP complex that is located in the nucleolus." [GOC:vw, ISBN:0879695897, PMID:17284456, PMID:20227365] synonym: "box H/ACA snoRNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:17284456] is_a: GO:0044452 ! nucleolar part is_a: GO:0072588 ! box H/ACA RNP complex [Term] id: GO:0031430 name: M band namespace: cellular_component def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815316194] synonym: "M disc" EXACT [] synonym: "M line" NARROW [] synonym: "mesophragma" EXACT [] synonym: "midline" BROAD [] xref: Wikipedia:Sarcomere#bands is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0031672 ! A band [Term] id: GO:0031431 name: Dbf4-dependent protein kinase complex namespace: cellular_component def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100] synonym: "Cdc7-Dbf4 complex" NARROW [] synonym: "DDK" EXACT [] synonym: "Hsk1-Dfp1 kinase complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031432 name: titin binding namespace: molecular_function def: "Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively." [GOC:mah, PMID:10481174] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031433 name: telethonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase." [GOC:mah, PMID:10481174] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031434 name: mitogen-activated protein kinase kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase." [GOC:mah] synonym: "MAPKK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0031435 name: mitogen-activated protein kinase kinase kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [GOC:bf] synonym: "MAPKKK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0031436 name: BRCA1-BARD1 complex namespace: cellular_component def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778] is_a: GO:0000152 ! nuclear ubiquitin ligase complex [Term] id: GO:0031437 name: regulation of mRNA cleavage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] is_a: GO:0050684 ! regulation of mRNA processing relationship: regulates GO:0006379 ! mRNA cleavage [Term] id: GO:0031438 name: negative regulation of mRNA cleavage namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage." [GOC:mah] synonym: "down regulation of mRNA cleavage" EXACT [] synonym: "down-regulation of mRNA cleavage" EXACT [] synonym: "downregulation of mRNA cleavage" EXACT [] synonym: "inhibition of mRNA cleavage" NARROW [] is_a: GO:0031437 ! regulation of mRNA cleavage is_a: GO:0050686 ! negative regulation of mRNA processing relationship: negatively_regulates GO:0006379 ! mRNA cleavage [Term] id: GO:0031439 name: positive regulation of mRNA cleavage namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA cleavage." [GOC:mah] synonym: "activation of mRNA cleavage" NARROW [] synonym: "stimulation of mRNA cleavage" NARROW [] synonym: "up regulation of mRNA cleavage" EXACT [] synonym: "up-regulation of mRNA cleavage" EXACT [] synonym: "upregulation of mRNA cleavage" EXACT [] is_a: GO:0031437 ! regulation of mRNA cleavage is_a: GO:0050685 ! positive regulation of mRNA processing relationship: positively_regulates GO:0006379 ! mRNA cleavage [Term] id: GO:0031440 name: regulation of mRNA 3'-end processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] is_a: GO:0050684 ! regulation of mRNA processing relationship: regulates GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0031441 name: negative regulation of mRNA 3'-end processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] synonym: "down regulation of mRNA 3'-end processing" EXACT [] synonym: "down-regulation of mRNA 3'-end processing" EXACT [] synonym: "downregulation of mRNA 3'-end processing" EXACT [] synonym: "inhibition of mRNA 3'-end processing" NARROW [] is_a: GO:0031440 ! regulation of mRNA 3'-end processing is_a: GO:0050686 ! negative regulation of mRNA processing relationship: negatively_regulates GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0031442 name: positive regulation of mRNA 3'-end processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] synonym: "activation of mRNA 3'-end processing" NARROW [] synonym: "stimulation of mRNA 3'-end processing" NARROW [] synonym: "up regulation of mRNA 3'-end processing" EXACT [] synonym: "up-regulation of mRNA 3'-end processing" EXACT [] synonym: "upregulation of mRNA 3'-end processing" EXACT [] is_a: GO:0031440 ! regulation of mRNA 3'-end processing is_a: GO:0050685 ! positive regulation of mRNA processing relationship: positively_regulates GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0031443 name: fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability." [GOC:ef, GOC:mah, GOC:mtg_muscle] synonym: "fast-twitch skeletal fiber contraction" EXACT [] synonym: "fast-twitch skeletal fibre contraction" EXACT [] synonym: "fast-twitch skeletal muscle fibre contraction" EXACT [] synonym: "fast-twitch skeletal myofiber contraction" EXACT [] synonym: "fast-twitch skeletal myofibre contraction" EXACT [] is_a: GO:0014721 ! twitch skeletal muscle contraction [Term] id: GO:0031444 name: slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue." [GOC:ef, GOC:mah, GOC:mtg_muscle] synonym: "slow-twitch skeletal muscle fibre contraction" EXACT [] is_a: GO:0014721 ! twitch skeletal muscle contraction [Term] id: GO:0031445 name: regulation of heterochromatin formation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah] is_a: GO:0010847 ! regulation of chromatin assembly relationship: regulates GO:0031507 ! heterochromatin formation [Term] id: GO:0031446 name: regulation of fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction relationship: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction [Term] id: GO:0031447 name: negative regulation of fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "down regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "down-regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "downregulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "inhibition of fast-twitch skeletal muscle contraction" NARROW [] synonym: "negative regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction relationship: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction [Term] id: GO:0031448 name: positive regulation of fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "activation of fast-twitch skeletal muscle contraction" NARROW [] synonym: "positive regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of fast-twitch skeletal muscle contraction" NARROW [] synonym: "up regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "up-regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "upregulation of fast-twitch skeletal muscle contraction" EXACT [] is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction relationship: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction [Term] id: GO:0031449 name: regulation of slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction relationship: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction [Term] id: GO:0031450 name: negative regulation of slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "down regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "down-regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "downregulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "inhibition of slow-twitch skeletal muscle contraction" NARROW [] synonym: "negative regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction relationship: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction [Term] id: GO:0031451 name: positive regulation of slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "activation of slow-twitch skeletal muscle contraction" NARROW [] synonym: "positive regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of slow-twitch skeletal muscle contraction" NARROW [] synonym: "up regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "up-regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "upregulation of slow-twitch skeletal muscle contraction" EXACT [] is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction relationship: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction [Term] id: GO:0031452 name: negative regulation of heterochromatin formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah] synonym: "down regulation of heterochromatin formation" EXACT [] synonym: "down-regulation of heterochromatin formation" EXACT [] synonym: "downregulation of heterochromatin formation" EXACT [] synonym: "inhibition of heterochromatin formation" NARROW [] is_a: GO:0031445 ! regulation of heterochromatin formation is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly relationship: negatively_regulates GO:0031507 ! heterochromatin formation [Term] id: GO:0031453 name: positive regulation of heterochromatin formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah] synonym: "activation of heterochromatin formation" NARROW [] synonym: "stimulation of heterochromatin formation" NARROW [] synonym: "up regulation of heterochromatin formation" EXACT [] synonym: "up-regulation of heterochromatin formation" EXACT [] synonym: "upregulation of heterochromatin formation" EXACT [] is_a: GO:0031445 ! regulation of heterochromatin formation is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly relationship: positively_regulates GO:0031507 ! heterochromatin formation [Term] id: GO:0031454 name: regulation of extent of heterochromatin formation namespace: biological_process def: "Any process that modulates the extent or location of heterochromatin formation." [GOC:mah] synonym: "regulation of heterochromatin spreading" RELATED [] is_a: GO:0031445 ! regulation of heterochromatin formation [Term] id: GO:0031455 name: glycine betaine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycine betaine, N-trimethylglycine." [GOC:mah] subset: gosubset_prok synonym: "glycine betaine metabolism" EXACT [] synonym: "N-trimethylglycine metabolic process" EXACT [] synonym: "N-trimethylglycine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006577 ! betaine metabolic process [Term] id: GO:0031456 name: glycine betaine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine." [GOC:mah] subset: gosubset_prok synonym: "glycine betaine anabolism" EXACT [] synonym: "glycine betaine biosynthesis" EXACT [] synonym: "glycine betaine formation" EXACT [] synonym: "glycine betaine synthesis" EXACT [] synonym: "N-trimethylglycine biosynthesis" EXACT [] synonym: "N-trimethylglycine biosynthetic process" EXACT [] is_a: GO:0006578 ! betaine biosynthetic process is_a: GO:0031455 ! glycine betaine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0031457 name: glycine betaine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine." [GOC:mah] synonym: "glycine betaine breakdown" EXACT [] synonym: "glycine betaine catabolism" EXACT [] synonym: "glycine betaine degradation" EXACT [] synonym: "N-trimethylglycine catabolic process" EXACT [] synonym: "N-trimethylglycine catabolism" EXACT [] is_a: GO:0006579 ! betaine catabolic process is_a: GO:0031455 ! glycine betaine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process [Term] id: GO:0031458 name: betaine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)." [GOC:mlg] synonym: "betaine ABC transporter" NARROW [] is_a: GO:0015199 ! betaine transmembrane transporter activity is_a: GO:0031263 ! amine-transporting ATPase activity [Term] id: GO:0031459 name: glycine betaine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)." [GOC:mlg] synonym: "glycine betaine ABC transporter" NARROW [] synonym: "N-trimethylglycine-transporting ATPase activity" EXACT [] is_a: GO:0031458 ! betaine-transporting ATPase activity [Term] id: GO:0031460 name: glycine betaine transport namespace: biological_process def: "The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "N-trimethylglycine transport" EXACT [] is_a: GO:0015838 ! betaine transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0031461 name: cullin-RING ubiquitin ligase complex namespace: cellular_component def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] synonym: "CRL complex" EXACT [] synonym: "cullin complex" EXACT [] synonym: "cullin-RING ligase" RELATED [] is_a: GO:0000151 ! ubiquitin ligase complex [Term] id: GO:0031462 name: Cul2-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] synonym: "CBC complex" BROAD [] synonym: "CDL2 complex" EXACT [] synonym: "CRL2 complex" EXACT [] synonym: "cullin-RING ligase 2" EXACT [] synonym: "EC2S complex" BROAD [] synonym: "ECS complex" BROAD [] synonym: "SCF2 complex" RELATED [] synonym: "VBC complex" NARROW [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031463 name: Cul3-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] synonym: "BC3B complex" EXACT [] synonym: "BCR3 complex" EXACT [] synonym: "CDL3 complex" EXACT [] synonym: "CRL3 complex" EXACT [] synonym: "cullin-RING ligase 3" EXACT [] synonym: "SCF3 complex" RELATED [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031464 name: Cul4A-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063] synonym: "CDL4 complex" EXACT [] synonym: "CRL4 complex" EXACT [] synonym: "cullin-RING ligase 4A" EXACT [] synonym: "DCX complex" EXACT [] synonym: "SCF4 complex" RELATED [] synonym: "VDC complex" NARROW [] is_a: GO:0080008 ! CUL4 RING ubiquitin ligase complex [Term] id: GO:0031465 name: Cul4B-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063] synonym: "cullin-RING ligase 4B" EXACT [] is_a: GO:0080008 ! CUL4 RING ubiquitin ligase complex [Term] id: GO:0031466 name: Cul5-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] synonym: "CDL5 complex" EXACT [] synonym: "CRL5 complex" EXACT [] synonym: "cullin-RING ligase 5" EXACT [] synonym: "EC2S complex" BROAD [] synonym: "SCF5 complex" RELATED [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031467 name: Cul7-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063] synonym: "CDL7 complex" EXACT [] synonym: "CRL7 complex" EXACT [] synonym: "cullin-RING ligase 7" EXACT [] synonym: "SCF7 complex" EXACT [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031468 name: nuclear envelope reassembly namespace: biological_process def: "The reformation of the nuclear envelope following its breakdown in the context of a normal process." [GOC:mah] is_a: GO:0006998 ! nuclear envelope organization [Term] id: GO:0031469 name: polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] subset: goslim_pir subset: gosubset_prok is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0031470 name: carboxysome namespace: cellular_component def: "An organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708] subset: gosubset_prok xref: Wikipedia:Carboxysome is_a: GO:0031469 ! polyhedral organelle [Term] id: GO:0031471 name: ethanolamine degradation polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753] subset: gosubset_prok synonym: "ethanolamine metabolosome" RELATED [] is_a: GO:0031469 ! polyhedral organelle [Term] id: GO:0031472 name: propanediol degradation polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] subset: gosubset_prok is_a: GO:0031469 ! polyhedral organelle [Term] id: GO:0031473 name: myosin III binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class III myosin; myosin III is monomeric and has an N terminal kinase domain." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0031474 name: myosin IV complex namespace: cellular_component def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031475 name: myosin V complex namespace: cellular_component def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031476 name: myosin VI complex namespace: cellular_component def: "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031477 name: myosin VII complex namespace: cellular_component def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031478 name: myosin VIII complex namespace: cellular_component def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031479 name: myosin IX complex namespace: cellular_component def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031480 name: myosin X complex namespace: cellular_component def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031481 name: myosin XI complex namespace: cellular_component def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031482 name: myosin XII complex namespace: cellular_component def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031483 name: myosin XIII complex namespace: cellular_component def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031484 name: myosin XIV complex namespace: cellular_component def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031485 name: myosin XV complex namespace: cellular_component def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031486 name: myosin XVI complex namespace: cellular_component def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031487 name: myosin XVII complex namespace: cellular_component def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031488 name: myosin XVIII complex namespace: cellular_component def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031489 name: myosin V binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0031490 name: chromatin DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah] is_a: GO:0003682 ! chromatin binding is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0031491 name: nucleosome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] is_a: GO:0003682 ! chromatin binding [Term] id: GO:0031492 name: nucleosomal DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DNA portion of a nucleosome." [GOC:mah] is_a: GO:0031490 ! chromatin DNA binding is_a: GO:0031491 ! nucleosome binding [Term] id: GO:0031493 name: nucleosomal histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone that is assembled into a nucleosome." [GOC:mah] is_a: GO:0031491 ! nucleosome binding is_a: GO:0042393 ! histone binding [Term] id: GO:0031494 name: regulation of mating type switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [GOC:mah] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0007533 ! mating type switching [Term] id: GO:0031495 name: negative regulation of mating type switching namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching." [GOC:mah] synonym: "down regulation of mating type switching" EXACT [] synonym: "down-regulation of mating type switching" EXACT [] synonym: "downregulation of mating type switching" EXACT [] synonym: "inhibition of mating type switching" NARROW [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0031494 ! regulation of mating type switching is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0007533 ! mating type switching [Term] id: GO:0031496 name: positive regulation of mating type switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mating type switching." [GOC:mah] synonym: "activation of mating type switching" NARROW [] synonym: "stimulation of mating type switching" NARROW [] synonym: "up regulation of mating type switching" EXACT [] synonym: "up-regulation of mating type switching" EXACT [] synonym: "upregulation of mating type switching" EXACT [] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:0031494 ! regulation of mating type switching is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0007533 ! mating type switching [Term] id: GO:0031497 name: chromatin assembly namespace: biological_process def: "The assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html] synonym: "establishment of chromatin architecture" EXACT [GOC:mah] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0006323 ! DNA packaging [Term] id: GO:0031498 name: chromatin disassembly namespace: biological_process def: "The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0071845 ! cellular component disassembly at cellular level [Term] id: GO:0031499 name: TRAMP complex namespace: cellular_component def: "A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control." [PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137] synonym: "TRAMP4 complex" NARROW [] synonym: "TRAMP5 complex" NARROW [] synonym: "Trf4 complex" NARROW [] synonym: "Trf4 poly(A) polymerase complex" NARROW [] synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" NARROW [] xref: Wikipedia:TRAMP_complex is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0031500 name: Tea1 cell-end complex namespace: cellular_component def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270] is_a: GO:0005875 ! microtubule associated complex is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0000133 ! polarisome [Term] id: GO:0031501 name: mannosyltransferase complex namespace: cellular_component def: "A complex that posseses mannosyltransferase activity." [GOC:mah] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031502 name: dolichyl-phosphate-mannose-protein mannosyltransferase complex namespace: cellular_component def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, PMID:15948957] synonym: "PMT family mannosyltransferase complex" RELATED [] synonym: "protein O-mannosyltransferase complex" EXACT [] is_a: GO:0031501 ! mannosyltransferase complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0031503 name: protein complex localization namespace: biological_process def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] subset: gosubset_prok synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization [Term] id: GO:0031504 name: peptidoglycan-based cell wall organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "peptidoglycan-based cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007047 ! cellular cell wall organization [Term] id: GO:0031505 name: fungal-type cell wall organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] subset: goslim_yeast synonym: "beta-glucan-containing cell wall organization and biogenesis" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall organisation" NARROW [] synonym: "chitin- and beta-glucan-containing cell wall organization and biogenesis" NARROW [] synonym: "chitin-containing cell wall organization and biogenesis" RELATED [] synonym: "fungal-type cell wall organization and biogenesis" RELATED [] is_a: GO:0007047 ! cellular cell wall organization is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis [Term] id: GO:0031506 name: cell wall glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues." [GOC:mah] subset: gosubset_prok synonym: "cell wall glycoprotein anabolism" EXACT [] synonym: "cell wall glycoprotein biosynthesis" EXACT [] synonym: "cell wall glycoprotein formation" EXACT [] synonym: "cell wall glycoprotein synthesis" EXACT [] is_a: GO:0009101 ! glycoprotein biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process [Term] id: GO:0031507 name: heterochromatin formation namespace: biological_process def: "The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah] synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah] synonym: "heterochromatin assembly" EXACT [] is_a: GO:0006338 ! chromatin remodeling is_a: GO:0031497 ! chromatin assembly is_a: GO:0070828 ! heterochromatin organization [Term] id: GO:0031508 name: centromeric heterochromatin formation namespace: biological_process def: "The assembly of chromatin into heterochromatin near the centromere." [GOC:mah] synonym: "centric heterochromatin formation" RELATED [] synonym: "centromeric heterochromatin assembly" EXACT [] synonym: "centromeric heterochromatin biosynthesis" EXACT [] is_a: GO:0031055 ! chromatin remodeling at centromere is_a: GO:0031507 ! heterochromatin formation relationship: part_of GO:0034508 ! centromere complex assembly [Term] id: GO:0031509 name: telomeric heterochromatin formation namespace: biological_process def: "The assembly of chromatin into heterochromatin at the telomere." [GOC:mah] synonym: "telomeric heterochromatin assembly" EXACT [] is_a: GO:0031507 ! heterochromatin formation [Term] id: GO:0031510 name: SUMO activating enzyme complex namespace: cellular_component def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841] synonym: "SAE" EXACT [] synonym: "SUMO E1 activator enzyme complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0031511 name: Mis6-Sim4 complex namespace: cellular_component def: "A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182] synonym: "Mis6 centromere subcomplex" NARROW [] synonym: "Mis6-Mal2-Sim4 centromere complex" EXACT [GOC:vw, PMID:21445296] synonym: "Sim4 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000939 ! condensed chromosome inner kinetochore [Term] id: GO:0031512 name: motile primary cilium namespace: cellular_component def: "A primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] comment: Note that this term should not be confused with 'motile cilium ; GO:0031514': Motile primary cilia are distinct from motile cilia (GO:0031514) that are typically present on epithelial cells in multiple copies and move in a whip-like, as opposed to rotational, manner. synonym: "motile primary cilia" EXACT [GOC:curators] synonym: "nodal cilium" RELATED [GOC:curators] is_a: GO:0072372 ! primary cilium [Term] id: GO:0031513 name: nonmotile primary cilium namespace: cellular_component def: "A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] synonym: "immotile primary cilium" EXACT [GOC:curators] synonym: "nonmotile primary cilia" EXACT [GOC:curators] synonym: "sensory cilium" EXACT [GOC:curators] is_a: GO:0072372 ! primary cilium [Term] id: GO:0031514 name: motile cilium namespace: cellular_component def: "A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] comment: Note that this term should not be confused with 'motile primary cilium ; GO:0031512': Motile cilia are distinct from motile primary cilia (GO:0031512) that are typically present during embryogenesis in a single copy per cell, affect asymmetric body plan organization, and move in a rotational manner, as opposed to a whip-like, manner. synonym: "motile cilia" EXACT [GOC:curators] synonym: "motile secondary cilium" RELATED [GOC:curators] is_a: GO:0005929 ! cilium [Term] id: GO:0031515 name: tRNA (m1A) methyltransferase complex namespace: cellular_component def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239] subset: gosubset_prok is_a: GO:0043527 ! tRNA methyltransferase complex [Term] id: GO:0031516 name: far-red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation." [GOC:nln] is_a: GO:0009883 ! red or far-red light photoreceptor activity [Term] id: GO:0031517 name: red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation." [GOC:nln] is_a: GO:0009883 ! red or far-red light photoreceptor activity [Term] id: GO:0031518 name: CBF3 complex namespace: cellular_component def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0031519 name: PcG protein complex namespace: cellular_component def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908] subset: goslim_pir synonym: "Polycomb Group protein complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0031520 name: plasma membrane of cell tip namespace: cellular_component def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0051286 ! cell tip [Term] id: GO:0031521 name: spitzenkorper namespace: cellular_component def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part relationship: part_of GO:0001411 ! hyphal tip [Term] id: GO:0031522 name: cell envelope Sec protein transport complex namespace: cellular_component def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC." [GOC:mtg_sensu, PMID:15223057] comment: Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial Type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'. subset: gosubset_prok synonym: "plasma membrane Sec complex" RELATED [] synonym: "Sec complex" BROAD [] synonym: "Sec secretion complex" NARROW [] synonym: "Sec translocation complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0031523 name: Myb complex namespace: cellular_component def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] synonym: "Myeloblastosis proto-oncogene protein complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0031524 name: menthol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] subset: gosubset_prok synonym: "menthol metabolism" EXACT [] is_a: GO:0043692 ! monoterpene metabolic process [Term] id: GO:0031525 name: menthol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] subset: gosubset_prok synonym: "menthol anabolism" EXACT [] synonym: "menthol biosynthesis" EXACT [] synonym: "menthol formation" EXACT [] synonym: "menthol synthesis" EXACT [] is_a: GO:0031524 ! menthol metabolic process is_a: GO:0043693 ! monoterpene biosynthetic process [Term] id: GO:0031526 name: brush border membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0005903 ! brush border [Term] id: GO:0031527 name: filopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0030175 ! filopodium [Term] id: GO:0031528 name: microvillus membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0005902 ! microvillus [Term] id: GO:0031529 name: ruffle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell." [GOC:mah, PMID:10036235] synonym: "ruffle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030030 ! cell projection organization [Term] id: GO:0031530 name: gonadotropin-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone, a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." [PMID:15196882] is_a: GO:0051428 ! peptide hormone receptor binding [Term] id: GO:0031531 name: thyrotropin-releasing hormone receptor binding namespace: molecular_function alt_id: GO:0031888 def: "Interacting selectively and non-covalently with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary." [PMID:8592728] synonym: "thyrotropin releasing hormone receptor binding" EXACT [] synonym: "thyrotropin-releasing hormone receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding is_a: GO:0051428 ! peptide hormone receptor binding [Term] id: GO:0031532 name: actin cytoskeleton reorganization namespace: biological_process alt_id: GO:0007012 def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] synonym: "actin cytoskeleton remodeling" EXACT [] synonym: "actin cytoskeleton reorganisation" EXACT [GOC:curators] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0031533 name: mRNA cap methyltransferase complex namespace: cellular_component def: "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220] synonym: "mRNA (guanine-N7) methyltransferase complex" EXACT [] synonym: "mRNA capping enzyme complex" EXACT [GOC:vw] is_a: GO:0034708 ! methyltransferase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0031534 name: minus-end directed microtubule sliding namespace: biological_process def: "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules." [GOC:mah, GOC:vw] is_a: GO:0051012 ! microtubule sliding [Term] id: GO:0031535 name: plus-end directed microtubule sliding namespace: biological_process def: "The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules." [GOC:mah, GOC:vw] is_a: GO:0051012 ! microtubule sliding [Term] id: GO:0031536 name: positive regulation of exit from mitosis namespace: biological_process def: "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah] synonym: "activation of exit from mitosis" NARROW [] synonym: "stimulation of exit from mitosis" NARROW [] synonym: "up regulation of exit from mitosis" EXACT [] synonym: "up-regulation of exit from mitosis" EXACT [] synonym: "upregulation of exit from mitosis" EXACT [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0010458 ! exit from mitosis [Term] id: GO:0031537 name: regulation of anthocyanin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] synonym: "regulation of anthocyanin metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0046283 ! anthocyanin metabolic process [Term] id: GO:0031538 name: negative regulation of anthocyanin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] synonym: "down regulation of anthocyanin metabolic process" EXACT [] synonym: "down-regulation of anthocyanin metabolic process" EXACT [] synonym: "downregulation of anthocyanin metabolic process" EXACT [] synonym: "inhibition of anthocyanin metabolic process" NARROW [] synonym: "negative regulation of anthocyanin metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process relationship: negatively_regulates GO:0046283 ! anthocyanin metabolic process [Term] id: GO:0031539 name: positive regulation of anthocyanin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] synonym: "activation of anthocyanin metabolic process" NARROW [] synonym: "positive regulation of anthocyanin metabolism" EXACT [] synonym: "stimulation of anthocyanin metabolic process" NARROW [] synonym: "up regulation of anthocyanin metabolic process" EXACT [] synonym: "up-regulation of anthocyanin metabolic process" EXACT [] synonym: "upregulation of anthocyanin metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process relationship: positively_regulates GO:0046283 ! anthocyanin metabolic process [Term] id: GO:0031540 name: regulation of anthocyanin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] synonym: "regulation of anthocyanin anabolism" EXACT [] synonym: "regulation of anthocyanin biosynthesis" EXACT [] synonym: "regulation of anthocyanin formation" EXACT [] synonym: "regulation of anthocyanin synthesis" EXACT [] is_a: GO:0009962 ! regulation of flavonoid biosynthetic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process relationship: regulates GO:0009718 ! anthocyanin biosynthetic process [Term] id: GO:0031541 name: negative regulation of anthocyanin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] synonym: "down regulation of anthocyanin biosynthetic process" EXACT [] synonym: "down-regulation of anthocyanin biosynthetic process" EXACT [] synonym: "downregulation of anthocyanin biosynthetic process" EXACT [] synonym: "inhibition of anthocyanin biosynthetic process" NARROW [] synonym: "negative regulation of anthocyanin anabolism" EXACT [] synonym: "negative regulation of anthocyanin biosynthesis" EXACT [] synonym: "negative regulation of anthocyanin formation" EXACT [] synonym: "negative regulation of anthocyanin synthesis" EXACT [] is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process relationship: negatively_regulates GO:0009718 ! anthocyanin biosynthetic process [Term] id: GO:0031542 name: positive regulation of anthocyanin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] synonym: "activation of anthocyanin biosynthetic process" NARROW [] synonym: "positive regulation of anthocyanin anabolism" EXACT [] synonym: "positive regulation of anthocyanin biosynthesis" EXACT [] synonym: "positive regulation of anthocyanin formation" EXACT [] synonym: "positive regulation of anthocyanin synthesis" EXACT [] synonym: "stimulation of anthocyanin biosynthetic process" NARROW [] synonym: "up regulation of anthocyanin biosynthetic process" EXACT [] synonym: "up-regulation of anthocyanin biosynthetic process" EXACT [] synonym: "upregulation of anthocyanin biosynthetic process" EXACT [] is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process relationship: positively_regulates GO:0009718 ! anthocyanin biosynthetic process [Term] id: GO:0031543 name: peptidyl-proline dioxygenase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein." [GOC:mah] is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0031544 name: peptidyl-proline 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2." [GOC:mah] is_a: GO:0031543 ! peptidyl-proline dioxygenase activity [Term] id: GO:0031545 name: peptidyl-proline 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2." [GOC:mah] synonym: "HIF-type prolyl 4-hydroxylase" NARROW [] synonym: "prolyl 4-hydroxylase" BROAD [] is_a: GO:0031543 ! peptidyl-proline dioxygenase activity [Term] id: GO:0031546 name: brain-derived neurotrophic factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the brain-derived neurotrophic factor receptor." [GOC:mah] synonym: "BDNF receptor binding" EXACT [] synonym: "brain-derived neurotrophic factor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0031547 name: brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:mah] synonym: "BDNF receptor signaling pathway" EXACT [] synonym: "BDNF signalling pathway" EXACT [] synonym: "brain-derived neurotrophic factor receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0031548 name: regulation of brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] synonym: "regulation of BDNF receptor signaling pathway" EXACT [] synonym: "regulation of BDNF receptor signalling pathway" EXACT [] synonym: "regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0031549 name: negative regulation of brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] synonym: "down regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "down-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "downregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "inhibition of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] synonym: "negative regulation of BDNF receptor signaling pathway" EXACT [] synonym: "negative regulation of BDNF receptor signalling pathway" EXACT [] synonym: "negative regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway relationship: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0031550 name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] synonym: "activation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] synonym: "positive regulation of BDNF receptor signaling pathway" EXACT [] synonym: "positive regulation of BDNF receptor signalling pathway" EXACT [] synonym: "positive regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] synonym: "stimulation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] synonym: "up regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "up-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "upregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway relationship: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0031551 name: regulation of brain-derived neurotrophic factor receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor receptor activity." [GOC:mah] synonym: "regulation of BDNF receptor activity" EXACT [] is_a: GO:0010469 ! regulation of receptor activity is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway is_a: GO:0043393 ! regulation of protein binding is_a: GO:0061097 ! regulation of protein tyrosine kinase activity [Term] id: GO:0031552 name: negative regulation of brain-derived neurotrophic factor receptor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor receptor activity." [GOC:mah] synonym: "down regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "down-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "downregulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "inhibition of brain-derived neurotrophic factor receptor activity" NARROW [] synonym: "negative regulation of BDNF receptor activity" EXACT [] is_a: GO:0031549 ! negative regulation of brain-derived neurotrophic factor receptor signaling pathway is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor receptor activity is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity is_a: GO:2000272 ! negative regulation of receptor activity [Term] id: GO:0031553 name: positive regulation of brain-derived neurotrophic factor receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor receptor activity." [GOC:mah] synonym: "activation of brain-derived neurotrophic factor receptor activity" NARROW [] synonym: "positive regulation of BDNF receptor activity" EXACT [] synonym: "stimulation of brain-derived neurotrophic factor receptor activity" NARROW [] synonym: "up regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "up-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "upregulation of brain-derived neurotrophic factor receptor activity" EXACT [] is_a: GO:0031550 ! positive regulation of brain-derived neurotrophic factor receptor signaling pathway is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor receptor activity is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity is_a: GO:2000273 ! positive regulation of receptor activity [Term] id: GO:0031554 name: regulation of transcription termination, DNA-dependent namespace: biological_process def: "Any process that modulates the frequency, rate, extent, or location of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:mlg, GOC:txnOH] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0043244 ! regulation of protein complex disassembly relationship: regulates GO:0006353 ! transcription termination, DNA-dependent [Term] id: GO:0031555 name: transcriptional attenuation namespace: biological_process def: "Regulation of transcription through variation in where transcription termination occurs." [GOC:dh, GOC:mlg, ISBN:0198542682] xref: Wikipedia:Attenuator_(genetics) is_a: GO:0031554 ! regulation of transcription termination, DNA-dependent [Term] id: GO:0031556 name: transcriptional attenuation by ribosome namespace: biological_process def: "A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch." [GOC:dh, GOC:mlg, ISBN:0198542682] synonym: "ribosome-mediated transcriptional attenuation" EXACT [GOC:dph, GOC:tb] is_a: GO:0031555 ! transcriptional attenuation [Term] id: GO:0031557 name: induction of programmed cell death in response to chemical stimulus namespace: biological_process def: "A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus." [GOC:mah] synonym: "induction of programmed cell death in response to chemical substance" EXACT [] is_a: GO:0012502 ! induction of programmed cell death is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0031558 name: induction of apoptosis in response to chemical stimulus namespace: biological_process def: "Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus." [GOC:mah] synonym: "induction of apoptosis in response to chemical substance" EXACT [] is_a: GO:0008624 ! induction of apoptosis by extracellular signals is_a: GO:0031557 ! induction of programmed cell death in response to chemical stimulus [Term] id: GO:0031559 name: oxidosqualene cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene." [GOC:ct] comment: Note that the phrase 'oxidosqualene cyclase' has been used to refer to enzymes that catalyze the reaction represented by 'lanosterol synthase activity ; GO:0000250'. subset: gosubset_prok synonym: "2,3-oxidosqualene cyclase activity" EXACT [GOC:mah] is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0031560 name: cellular bud neck polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790] is_a: GO:0000133 ! polarisome relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0031561 name: cellular bud tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790] is_a: GO:0000133 ! polarisome relationship: part_of GO:0005934 ! cellular bud tip [Term] id: GO:0031562 name: hyphal tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451] is_a: GO:0000133 ! polarisome relationship: part_of GO:0001411 ! hyphal tip [Term] id: GO:0031563 name: mating projection tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532] is_a: GO:0000133 ! polarisome is_a: GO:0044463 ! cell projection part relationship: part_of GO:0043332 ! mating projection tip [Term] id: GO:0031564 name: transcription antitermination namespace: biological_process def: "Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond a termination site." [ISBN:0198577788, PMID:12456320] synonym: "transcriptional readthrough" EXACT [] is_a: GO:0031555 ! transcriptional attenuation [Term] id: GO:0031565 name: cytokinesis checkpoint namespace: biological_process def: "A cell cycle checkpoint that ensures the correct temporal ordering of nuclear division and cytokinesis; arrests the cell cycle in G2 upon perturbation of cytokinetic structures. In Schizosaccharomyces, the checkpoint monitors formation and integrity of medial actomyosin ring and septum." [GOC:mah, PMID:15647375] synonym: "contractile ring checkpoint" EXACT [] is_a: GO:0000075 ! cell cycle checkpoint is_a: GO:0071775 ! regulation of cell cycle cytokinesis [Term] id: GO:0031566 name: contractile ring maintenance involved in cell cycle cytokinesis namespace: biological_process def: "The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb, GOC:vw] synonym: "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process is_a: GO:0032506 ! cytokinetic process is_a: GO:0071956 ! cellular component maintenance at cellular level relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0031567 name: cell size control checkpoint namespace: biological_process def: "Any cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size." [GOC:mah] synonym: "mitotic cell cycle cell size control checkpoint" EXACT [GOC:mah] is_a: GO:0007093 ! mitotic cell cycle checkpoint [Term] id: GO:0031568 name: mitotic cell cycle G1/S transition size control checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that blocks cell cycle progression from G1 to S phase until cells have reached a critical size." [GOC:mah] is_a: GO:0031567 ! cell size control checkpoint is_a: GO:0031575 ! mitotic cell cycle G1/S transition checkpoint [Term] id: GO:0031569 name: G2/M transition size control checkpoint namespace: biological_process def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until cells have reached a critical size." [GOC:mah] synonym: "mitotic cell cycle G2/M transition size control checkpoint" EXACT [GOC:mah] is_a: GO:0031567 ! cell size control checkpoint is_a: GO:0031576 ! G2/M transition checkpoint [Term] id: GO:0031570 name: DNA integrity checkpoint namespace: biological_process def: "Any cell cycle checkpoint that regulates cell cycle progression in response to changes in DNA structure." [GOC:mah, GOC:vw] is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0031571 name: mitotic cell cycle G1/S transition DNA damage checkpoint namespace: biological_process def: "A mitotic G1/S transition checkpoint that blocks entry into S phase in response to DNA damage." [GOC:mah] synonym: "mitotic G1 DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0000077 ! DNA damage checkpoint is_a: GO:0031575 ! mitotic cell cycle G1/S transition checkpoint [Term] id: GO:0031572 name: G2/M transition DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage." [GOC:mah] is_a: GO:0000077 ! DNA damage checkpoint is_a: GO:0031576 ! G2/M transition checkpoint [Term] id: GO:0031573 name: intra-S DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession." [GOC:vw] is_a: GO:0000077 ! DNA damage checkpoint [Term] id: GO:0031575 name: mitotic cell cycle G1/S transition checkpoint namespace: biological_process def: "A cell cycle checkpoint that blocks entry into S phase of the mitotic cell cycle." [GOC:mah] synonym: "mitotic G1/S checkpoint" EXACT [GOC:vw] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0071779 ! G1/S transition checkpoint is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0031576 name: G2/M transition checkpoint namespace: biological_process def: "A cell cycle checkpoint that blocks entry into M phase." [GOC:mah] synonym: "G2/M checkpoint" EXACT [] is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0031577 name: spindle checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays progression through the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:mah, PMID:15897186] xref: Wikipedia:Spindle_checkpoint is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0031578 name: mitotic cell cycle spindle orientation checkpoint namespace: biological_process def: "A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected." [GOC:clt, PMID:14616062] synonym: "SOC" EXACT [] synonym: "spindle position checkpoint" EXACT [] synonym: "SPOC" EXACT [] is_a: GO:0071174 ! mitotic cell cycle spindle checkpoint [Term] id: GO:0031579 name: membrane raft organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:dph, GOC:jl, GOC:mah] synonym: "lipid raft organization" EXACT [GOC:mah] synonym: "membrane raft organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0031580 name: membrane raft distribution namespace: biological_process def: "The process that establishes the spatial arrangement of membrane rafts within a cellular membrane." [GOC:mah] synonym: "lipid raft distribution" EXACT [] is_a: GO:0031579 ! membrane raft organization is_a: GO:0051665 ! membrane raft localization [Term] id: GO:0031581 name: hemidesmosome assembly namespace: biological_process def: "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina." [GOC:dgh, PMID:15983403] xref: Reactome:1253767 "Type I hemidesmosome assembly" xref: Reactome:1280700 "Type I hemidesmosome assembly" xref: Reactome:1299523 "Type I hemidesmosome assembly" xref: Reactome:1327284 "Type I hemidesmosome assembly" xref: Reactome:1353381 "Type I hemidesmosome assembly" xref: Reactome:1373552 "Type I hemidesmosome assembly" xref: Reactome:1451165 "Type I hemidesmosome assembly" xref: Reactome:1471509 "Type I hemidesmosome assembly" xref: Reactome:1483447 "Type I hemidesmosome assembly" xref: Reactome:446107 "Type I hemidesmosome assembly" is_a: GO:0007044 ! cell-substrate junction assembly [Term] id: GO:0031582 name: replication fork arrest at rDNA repeats namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer." [GOC:mah, GOC:vw] synonym: "replication fork arrest at ribosomal DNA repeats" EXACT [] synonym: "replication fork blocking at rDNA repeats" EXACT [] is_a: GO:0043007 ! maintenance of rDNA is_a: GO:0043111 ! replication fork arrest [Term] id: GO:0031583 name: activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway namespace: biological_process def: "A G-protein coupled signaling pathway that results in the activation of phospholipase D, causing an increase in cellular levels of phosphatidic acid." [GOC:mah, PMID:11812783, PMID:15924269] synonym: "G-protein signalling, phospholipase D activating pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0031584 ! activation of phospholipase D activity [Term] id: GO:0031584 name: activation of phospholipase D activity namespace: biological_process def: "Any process that initiates the activity of inactive phospholipase D." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0010518 ! positive regulation of phospholipase activity [Term] id: GO:0031585 name: regulation of inositol-1,4,5-triphosphate receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of the IP3 receptor." [GOC:dph, GOC:mah] synonym: "regulation of IP3 receptor activity" EXACT [GOC:dph] is_a: GO:0010469 ! regulation of receptor activity [Term] id: GO:0031586 name: negative regulation of inositol-1,4,5-trisphosphate receptor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the IP3 receptor." [GOC:dph, GOC:mah] synonym: "down regulation of IP3 receptor activity" EXACT [] synonym: "down-regulation of IP3 receptor activity" EXACT [] synonym: "downregulation of IP3 receptor activity" EXACT [] synonym: "inhibition of IP3 receptor activity" NARROW [] synonym: "negative regulation of IP3 receptor activity" RELATED [GOC:dph] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0031585 ! regulation of inositol-1,4,5-triphosphate receptor activity is_a: GO:2000272 ! negative regulation of receptor activity [Term] id: GO:0031587 name: positive regulation of inositol-1,4,5-trisphosphate receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of the IP3 receptor." [GOC:dph, GOC:mah] synonym: "activation of IP3 receptor activity" NARROW [] synonym: "positive regulation of IP3 receptor activity" EXACT [GOC:dph] synonym: "stimulation of IP3 receptor activity" NARROW [] synonym: "up regulation of IP3 receptor activity" EXACT [] synonym: "up-regulation of IP3 receptor activity" EXACT [] synonym: "upregulation of IP3 receptor activity" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031585 ! regulation of inositol-1,4,5-triphosphate receptor activity is_a: GO:2000273 ! positive regulation of receptor activity [Term] id: GO:0031588 name: AMP-activated protein kinase complex namespace: cellular_component def: "A protein complex that possesses AMP-dependent protein kinase activity." [GOC:mah] synonym: "5'-AMP-activated protein kinase complex" EXACT [] synonym: "Snf1 kinase complex" NARROW [] synonym: "Snf1 serine/threonine protein kinase complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031589 name: cell-substrate adhesion namespace: biological_process def: "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] subset: gosubset_prok is_a: GO:0007155 ! cell adhesion [Term] id: GO:0031590 name: wybutosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:mah, RNAmods:037] synonym: "wybutosine metabolism" EXACT [] synonym: "yW metabolic process" EXACT [] synonym: "yW metabolism" EXACT [] is_a: GO:0008617 ! guanosine metabolic process [Term] id: GO:0031591 name: wybutosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037] comment: Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe. synonym: "yW biosynthesis" EXACT [] synonym: "yW biosynthetic process" EXACT [] is_a: GO:0006400 ! tRNA modification is_a: GO:0031590 ! wybutosine metabolic process [Term] id: GO:0031592 name: centrosomal corona namespace: cellular_component def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah] comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material. is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0031593 name: polyubiquitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polymer of ubiqutin." [GOC:mah] synonym: "multiubiquitin binding" RELATED [] is_a: GO:0043130 ! ubiquitin binding [Term] id: GO:0031594 name: neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction." [GOC:nln] xref: NIF_Subcellular:sao1124888485 xref: Wikipedia:Neuromuscular_junction is_a: GO:0045202 ! synapse [Term] id: GO:0031595 name: nuclear proteasome complex namespace: cellular_component def: "A proteasome found in the nucleus of a cell." [GOC:mah] is_a: GO:0000502 ! proteasome complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0031596 name: ER proteasome complex namespace: cellular_component def: "A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah] is_a: GO:0000502 ! proteasome complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0031597 name: cytosolic proteasome complex namespace: cellular_component def: "A proteasome complex found in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu] is_a: GO:0000502 ! proteasome complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0031598 name: nuclear proteasome regulatory particle namespace: cellular_component def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0005838 ! proteasome regulatory particle is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031595 ! nuclear proteasome complex [Term] id: GO:0031599 name: ER proteasome regulatory particle namespace: cellular_component def: "The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] is_a: GO:0005838 ! proteasome regulatory particle is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0031596 ! ER proteasome complex [Term] id: GO:0031600 name: cytosolic proteasome regulatory particle namespace: cellular_component def: "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0005838 ! proteasome regulatory particle is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031597 ! cytosolic proteasome complex [Term] id: GO:0031601 name: nuclear proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0005839 ! proteasome core complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031595 ! nuclear proteasome complex [Term] id: GO:0031602 name: ER proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] is_a: GO:0005839 ! proteasome core complex is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0031596 ! ER proteasome complex [Term] id: GO:0031603 name: cytosolic proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu] is_a: GO:0005839 ! proteasome core complex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031597 ! cytosolic proteasome complex [Term] id: GO:0031604 name: nuclear proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031601 ! nuclear proteasome core complex [Term] id: GO:0031605 name: ER proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0031602 ! ER proteasome core complex [Term] id: GO:0031606 name: cytosolic proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031603 ! cytosolic proteasome core complex [Term] id: GO:0031607 name: nuclear proteasome core complex, beta-subunit complex namespace: cellular_component def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0019774 ! proteasome core complex, beta-subunit complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031601 ! nuclear proteasome core complex [Term] id: GO:0031608 name: ER proteasome core complex, beta-subunit complex namespace: cellular_component def: "The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] is_a: GO:0019774 ! proteasome core complex, beta-subunit complex is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0031602 ! ER proteasome core complex [Term] id: GO:0031609 name: cytosolic proteasome core complex, beta-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0019774 ! proteasome core complex, beta-subunit complex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031603 ! cytosolic proteasome core complex [Term] id: GO:0031610 name: nuclear proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle [Term] id: GO:0031611 name: ER proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0031599 ! ER proteasome regulatory particle [Term] id: GO:0031612 name: cytosolic proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell." [GOC:mah, GOC:mtg_sensu] is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle [Term] id: GO:0031613 name: nuclear proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle [Term] id: GO:0031614 name: ER proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0031599 ! ER proteasome regulatory particle [Term] id: GO:0031615 name: cytosolic proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle [Term] id: GO:0031616 name: spindle pole centrosome namespace: cellular_component def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah] is_a: GO:0005813 ! centrosome relationship: part_of GO:0000922 ! spindle pole [Term] id: GO:0031617 name: NMS complex namespace: cellular_component def: "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes." [PMID:16079914] synonym: "Ndc80-MIND-Spc7 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000776 ! kinetochore [Term] id: GO:0031618 name: nuclear centromeric heterochromatin namespace: cellular_component def: "A region of heterochromatin located near the centromere of a chromosome in the nucleus." [GOC:mah] synonym: "nuclear centric heterochromatin" EXACT [] is_a: GO:0005720 ! nuclear heterochromatin is_a: GO:0005721 ! centromeric heterochromatin [Term] id: GO:0031619 name: homologous chromosome orientation involved in meiotic metaphase I plate congression namespace: biological_process def: "The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096] synonym: "homologous chromosome orientation during meiosis" RELATED [GOC:dph, GOC:tb] synonym: "homologous chromosome orientation during meiosis I" RELATED [] is_a: GO:0051317 ! attachment of spindle microtubules to meiotic chromosome relationship: part_of GO:0043060 ! meiotic metaphase I plate congression [Term] id: GO:0031620 name: regulation of fever generation namespace: biological_process def: "Any process that modulates the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of pyrexia" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0031650 ! regulation of heat generation relationship: regulates GO:0001660 ! fever generation [Term] id: GO:0031621 name: negative regulation of fever generation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb] synonym: "down regulation of fever" EXACT [] synonym: "down-regulation of fever" EXACT [] synonym: "downregulation of fever" EXACT [] synonym: "inhibition of fever" NARROW [] synonym: "negative regulation of pyrexia" EXACT [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0031620 ! regulation of fever generation is_a: GO:0031651 ! negative regulation of heat generation relationship: negatively_regulates GO:0001660 ! fever generation [Term] id: GO:0031622 name: positive regulation of fever generation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of fever generation." [GOC:add] synonym: "activation of fever" NARROW [] synonym: "positive regulation of pyrexia" EXACT [] synonym: "stimulation of fever" NARROW [] synonym: "up regulation of fever" EXACT [] synonym: "up-regulation of fever" EXACT [] synonym: "upregulation of fever" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0031620 ! regulation of fever generation is_a: GO:0031652 ! positive regulation of heat generation relationship: positively_regulates GO:0001660 ! fever generation [Term] id: GO:0031623 name: receptor internalization namespace: biological_process def: "A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation; receptors are subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation. Receptor internalization serves as a mechanism to downregulate receptor signaling." [GOC:mah, PMID:15006537] is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0031624 name: ubiquitin conjugating enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0031625 name: ubiquitin protein ligase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] synonym: "ubiquitin ligase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0031626 name: beta-endorphin binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin." [GOC:nln, PMID:6267560] is_a: GO:0042165 ! neurotransmitter binding [Term] id: GO:0031627 name: telomeric loop formation namespace: biological_process def: "The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region." [GOC:vw, PMID:10338214] synonym: "t-loop biosynthesis" EXACT [] synonym: "t-loop formation" EXACT [] is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0031628 name: opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opioid receptor." [GOC:nln] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031629 name: synaptic vesicle fusion to presynaptic membrane namespace: biological_process def: "Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009] synonym: "synaptic vesicle fusion" BROAD [] synonym: "synaptic vesicle internalization" RELATED [] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0031630 name: regulation of synaptic vesicle fusion to presynaptic membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis relationship: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic membrane [Term] id: GO:0031631 name: negative regulation of synaptic vesicle fusion to presynaptic membrane namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] synonym: "down regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "down-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "downregulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "inhibition of synaptic vesicle fusion to presynaptic membrane" NARROW [] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic membrane relationship: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic membrane [Term] id: GO:0031632 name: positive regulation of synaptic vesicle fusion to presynaptic membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] synonym: "activation of synaptic vesicle fusion to presynaptic membrane" NARROW [] synonym: "stimulation of synaptic vesicle fusion to presynaptic membrane" NARROW [] synonym: "up regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "up-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "upregulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic membrane relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic membrane [Term] id: GO:0031633 name: xanthophore namespace: cellular_component def: "A chromatophore containing yellow pigment." [ISBN:0395825172] comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells. is_a: GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0031634 name: replication fork barrier binding namespace: molecular_function def: "Interacting selectively and non-covalently with replication fork barriers, sites that inhibit the progress of replication forks." [GOC:mah] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0031635 name: inhibition of adenylate cyclase activity by opioid receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "inhibition of adenylate cyclase activity by opioid receptor signalling pathway" EXACT [GOC:mah] synonym: "opioid receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0038003 ! opioid receptor signaling pathway [Term] id: GO:0031637 name: regulation of neuronal synaptic plasticity in response to neurotrophin namespace: biological_process def: "The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah, PMID:8703078] synonym: "neurotrophin-induced neuronal synaptic plasticity" EXACT [] is_a: GO:0048168 ! regulation of neuronal synaptic plasticity [Term] id: GO:0031638 name: zymogen activation namespace: biological_process def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] synonym: "zymogen activation by proteolytic cleavage" EXACT [] is_a: GO:0051605 ! protein maturation by peptide bond cleavage [Term] id: GO:0031639 name: plasminogen activation namespace: biological_process def: "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [PMID:9548733] synonym: "cleavage of plasminogen to plasmin" EXACT [] is_a: GO:0031638 ! zymogen activation [Term] id: GO:0031640 name: killing of cells of other organism namespace: biological_process alt_id: GO:0001908 def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir subset: gosubset_prok synonym: "killing of cells of another organism" EXACT [GOC:bf] synonym: "killing of cells of another, non-host, organism" NARROW [] is_a: GO:0001906 ! cell killing is_a: GO:0051704 ! multi-organism process [Term] id: GO:0031641 name: regulation of myelination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0051969 ! regulation of transmission of nerve impulse is_a: GO:2000021 ! regulation of ion homeostasis relationship: regulates GO:0042552 ! myelination [Term] id: GO:0031642 name: negative regulation of myelination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "down regulation of myelination" EXACT [] synonym: "down-regulation of myelination" EXACT [] synonym: "downregulation of myelination" EXACT [] synonym: "inhibition of myelination" NARROW [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031645 ! negative regulation of neurological system process is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0042552 ! myelination [Term] id: GO:0031643 name: positive regulation of myelination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "activation of myelination" NARROW [] synonym: "stimulation of myelination" NARROW [] synonym: "up regulation of myelination" EXACT [] synonym: "up-regulation of myelination" EXACT [] synonym: "upregulation of myelination" EXACT [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031646 ! positive regulation of neurological system process is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0042552 ! myelination [Term] id: GO:0031644 name: regulation of neurological system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurophysiological process" EXACT [] is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0050877 ! neurological system process [Term] id: GO:0031645 name: negative regulation of neurological system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of neurological process" EXACT [] synonym: "down-regulation of neurological process" EXACT [] synonym: "downregulation of neurological process" EXACT [] synonym: "inhibition of neurological process" NARROW [] synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of neurophysiological process" EXACT [] is_a: GO:0031644 ! regulation of neurological system process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0050877 ! neurological system process [Term] id: GO:0031646 name: positive regulation of neurological system process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of neurological process" NARROW [] synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of neurophysiological process" EXACT [] synonym: "stimulation of neurological process" NARROW [] synonym: "up regulation of neurological process" EXACT [] synonym: "up-regulation of neurological process" EXACT [] synonym: "upregulation of neurological process" EXACT [] is_a: GO:0031644 ! regulation of neurological system process is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0050877 ! neurological system process [Term] id: GO:0031647 name: regulation of protein stability namespace: biological_process def: "Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir subset: gosubset_prok is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0031648 name: protein destabilization namespace: biological_process def: "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah] synonym: "negative regulation of protein stability" EXACT [] is_a: GO:0031647 ! regulation of protein stability [Term] id: GO:0031649 name: heat generation namespace: biological_process def: "Any homeostatic process in which an organism produces heat, thereby raising its internal temperature." [GOC:mah] is_a: GO:0001659 ! temperature homeostasis [Term] id: GO:0031650 name: regulation of heat generation namespace: biological_process def: "Any process that modulates the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0031649 ! heat generation [Term] id: GO:0031651 name: negative regulation of heat generation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of heat generation" EXACT [] synonym: "down-regulation of heat generation" EXACT [] synonym: "downregulation of heat generation" EXACT [] synonym: "inhibition of heat generation" NARROW [] is_a: GO:0031650 ! regulation of heat generation is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0031649 ! heat generation [Term] id: GO:0031652 name: positive regulation of heat generation namespace: biological_process def: "Any process that activates or increases the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of heat generation" NARROW [] synonym: "stimulation of heat generation" NARROW [] synonym: "up regulation of heat generation" EXACT [] synonym: "up-regulation of heat generation" EXACT [] synonym: "upregulation of heat generation" EXACT [] is_a: GO:0031650 ! regulation of heat generation is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0031649 ! heat generation [Term] id: GO:0031653 name: heat dissipation namespace: biological_process def: "Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature." [GOC:mah] is_a: GO:0001659 ! temperature homeostasis [Term] id: GO:0031654 name: regulation of heat dissipation namespace: biological_process def: "Any process that modulates the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0031653 ! heat dissipation [Term] id: GO:0031655 name: negative regulation of heat dissipation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of heat dissipation" EXACT [] synonym: "down-regulation of heat dissipation" EXACT [] synonym: "downregulation of heat dissipation" EXACT [] synonym: "inhibition of heat dissipation" NARROW [] is_a: GO:0031654 ! regulation of heat dissipation is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0031653 ! heat dissipation [Term] id: GO:0031656 name: positive regulation of heat dissipation namespace: biological_process def: "Any process that activates or increases the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of heat dissipation" NARROW [] synonym: "stimulation of heat dissipation" NARROW [] synonym: "up regulation of heat dissipation" EXACT [] synonym: "up-regulation of heat dissipation" EXACT [] synonym: "upregulation of heat dissipation" EXACT [] is_a: GO:0031654 ! regulation of heat dissipation is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0031653 ! heat dissipation [Term] id: GO:0031657 name: regulation of cyclin-dependent protein kinase activity involved by G1/S namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CDK activity contributing to the G1/S transition of the cell cycle." [GOC:mah] synonym: "G1/S-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0031658 name: negative regulation of cyclin-dependent protein kinase activity involved in G1/S namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of CDK activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] is_a: GO:0031657 ! regulation of cyclin-dependent protein kinase activity involved by G1/S is_a: GO:0045736 ! negative regulation of cyclin-dependent protein kinase activity [Term] id: GO:0031659 name: positive regulation of cyclin-dependent protein kinase activity involved in G1/S namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CDK activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "positive regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] is_a: GO:0031657 ! regulation of cyclin-dependent protein kinase activity involved by G1/S is_a: GO:0045737 ! positive regulation of cyclin-dependent protein kinase activity [Term] id: GO:0031660 name: regulation of cyclin-dependent protein kinase activity involved in G2/M namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CDK activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G2/M-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb] is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0031661 name: negative regulation of cyclin-dependent protein kinase activity involved in G2/M namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of CDK activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] synonym: "G2/M-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb] is_a: GO:0031660 ! regulation of cyclin-dependent protein kinase activity involved in G2/M is_a: GO:0045736 ! negative regulation of cyclin-dependent protein kinase activity [Term] id: GO:0031662 name: positive regulation of cyclin-dependent protein kinase activity involved in G2/M namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CDK activity involved in the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G2/M-specific activation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G2/M-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "G2/M-specific stimulation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G2/M-specific up regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific up-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific upregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "positive regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb] is_a: GO:0031660 ! regulation of cyclin-dependent protein kinase activity involved in G2/M is_a: GO:0045737 ! positive regulation of cyclin-dependent protein kinase activity [Term] id: GO:0031663 name: lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated in response to detection of lipopolysaccharide. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [GOC:mah, PMID:15379975] synonym: "lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "LPS-mediated signaling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway is_a: GO:0071222 ! cellular response to lipopolysaccharide [Term] id: GO:0031664 name: regulation of lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] synonym: "regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "regulation of LPS-mediated signaling pathway" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0031665 name: negative regulation of lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] synonym: "down regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "down-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "downregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "inhibition of lipopolysaccharide-mediated signaling pathway" NARROW [] synonym: "negative regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "negative regulation of LPS-mediated signaling pathway" EXACT [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway relationship: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0031666 name: positive regulation of lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] synonym: "activation of lipopolysaccharide-mediated signaling pathway" NARROW [] synonym: "positive regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "positive regulation of LPS-mediated signaling pathway" EXACT [] synonym: "stimulation of lipopolysaccharide-mediated signaling pathway" NARROW [] synonym: "up regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "up-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "upregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway relationship: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0031667 name: response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] subset: gosubset_prok is_a: GO:0009991 ! response to extracellular stimulus [Term] id: GO:0031668 name: cellular response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0007154 ! cell communication is_a: GO:0009991 ! response to extracellular stimulus is_a: GO:0051716 ! cellular response to stimulus is_a: GO:0071496 ! cellular response to external stimulus [Term] id: GO:0031669 name: cellular response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] subset: gosubset_prok is_a: GO:0031667 ! response to nutrient levels is_a: GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0031670 name: cellular response to nutrient namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah] is_a: GO:0007584 ! response to nutrient is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0031671 name: primary cell septum biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division." [GOC:jl] is_a: GO:0032506 ! cytokinetic process is_a: GO:0071843 ! cellular component biogenesis at cellular level relationship: part_of GO:0000917 ! barrier septum formation [Term] id: GO:0031672 name: A band namespace: cellular_component def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131] synonym: "A disc" EXACT [] synonym: "anisotropic disc" EXACT [] synonym: "Q disc" EXACT [] synonym: "transverse disc" EXACT [] xref: Wikipedia:Sarcomere#bands is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0031673 name: H zone namespace: cellular_component def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131] synonym: "H band" EXACT [] synonym: "H disc" EXACT [] xref: Wikipedia:Sarcomere#bands is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0031672 ! A band [Term] id: GO:0031674 name: I band namespace: cellular_component def: "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] synonym: "I disc" EXACT [] synonym: "isotropic disc" EXACT [] synonym: "J disc" EXACT [] xref: Wikipedia:Sarcomere#bands is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0031676 name: plasma membrane-derived thylakoid membrane namespace: cellular_component def: "The pigmented membrane of a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane thylakoid membrane" EXACT [] is_a: GO:0042651 ! thylakoid membrane is_a: GO:0042717 ! plasma membrane-derived chromatophore membrane is_a: GO:0044422 ! organelle part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid [Term] id: GO:0031679 name: NADH dehydrogenase (plastoquinone) activity namespace: molecular_function alt_id: GO:0030024 def: "Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol." [EC:1.6.99.6, GOC:mah] synonym: "NADH:plastoquinone reductase activity" EXACT [] is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity [Term] id: GO:0031680 name: G-protein beta/gamma-subunit complex namespace: cellular_component def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah] comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. synonym: "G-beta/G-gamma complex" EXACT [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031681 name: G-protein beta-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein beta subunit." [GOC:mah] synonym: "G-beta protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0031682 name: G-protein gamma-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein gamma subunit." [GOC:mah] synonym: "G-gamma protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0031683 name: G-protein beta/gamma-subunit complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0031684 name: heterotrimeric G-protein complex cycle namespace: biological_process def: "The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits." [GOC:nln] is_a: GO:0043087 ! regulation of GTPase activity relationship: part_of GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0031685 name: adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenosine receptor." [GOC:mah, GOC:nln] synonym: "adenosine receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031686 name: A1 adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A1 adenosine receptor." [GOC:mah, GOC:nln] synonym: "A1 adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031687 name: A2A adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A2A adenosine receptor." [GOC:mah, GOC:nln] synonym: "A2A adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031688 name: A2B adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A2B adenosine receptor." [GOC:mah, GOC:nln] synonym: "A2B adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031689 name: A3 adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A3 adenosine receptor." [GOC:mah, GOC:nln] synonym: "A3 adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031690 name: adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adrenergic receptor." [GOC:mah, GOC:nln] synonym: "adrenergic receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031691 name: alpha-1A adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-1A adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1A adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031692 name: alpha-1B adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-1B adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1B adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031693 name: alpha-1D adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-1D adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1D adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031694 name: alpha-2A adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-2A adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2A adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031695 name: alpha-2B adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-2B adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2B adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031696 name: alpha-2C adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-2C adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2C adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031697 name: beta-1 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-1 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-1 adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031698 name: beta-2 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-2 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-2 adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031699 name: beta-3 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-3 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-3 adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031700 name: adrenomedullin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adrenomedullin receptor." [GOC:mah, GOC:nln] synonym: "adrenomedullin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031701 name: angiotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an angiotensin receptor." [GOC:mah, GOC:nln] synonym: "angiotensin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031702 name: type 1 angiotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 angiotensin receptor." [GOC:mah, GOC:nln] synonym: "AT1 receptor binding" EXACT [] synonym: "type 1 angiotensin receptor ligand" NARROW [] is_a: GO:0031701 ! angiotensin receptor binding [Term] id: GO:0031703 name: type 2 angiotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 angiotensin receptor." [GOC:mah, GOC:nln] synonym: "AT2 receptor binding" EXACT [] synonym: "type 2 angiotensin receptor ligand" NARROW [] is_a: GO:0031701 ! angiotensin receptor binding [Term] id: GO:0031704 name: apelin receptor binding namespace: molecular_function alt_id: GO:0042569 def: "Interacting selectively and non-covalently with an apelin receptor." [GOC:mah, GOC:nln, GOC:vp, PMID:12787050] synonym: "apelin receptor ligand" NARROW [] synonym: "APJ receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031705 name: bombesin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a bombesin receptor." [GOC:mah, GOC:nln] synonym: "bombesin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031706 name: subtype 3 bombesin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a subtype 3 bombesin receptor." [GOC:mah, GOC:nln] synonym: "subtype 3 bombesin receptor ligand" NARROW [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031707 name: endothelin A receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endothelin A receptor." [GOC:mah, GOC:nln] synonym: "endothelin A receptor ligand" NARROW [] synonym: "endothelin-1 receptor binding" EXACT [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031708 name: endothelin B receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endothelin B receptor." [GOC:mah, GOC:nln] synonym: "endothelin B receptor ligand" NARROW [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031709 name: gastrin-releasing peptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a gastrin-releasing peptide receptor." [GOC:mah, GOC:nln] synonym: "gastrin-releasing peptide receptor ligand" NARROW [] synonym: "GRP receptor binding" EXACT [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031710 name: neuromedin B receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuromedin B receptor." [GOC:mah, GOC:nln] synonym: "neuromedin B receptor ligand" NARROW [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031711 name: bradykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a bradykinin receptor." [GOC:mah, GOC:nln] synonym: "bradykinin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031712 name: B1 bradykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a B1 bradykinin receptor." [GOC:mah, GOC:nln] synonym: "B1 bradykinin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031713 name: B2 bradykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a B2 bradykinin receptor." [GOC:mah, GOC:nln] synonym: "B2 bradykinin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031714 name: C5a anaphylatoxin chemotactic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C5a anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] synonym: "C5a anaphylatoxin chemotactic receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031715 name: C5L2 anaphylatoxin chemotactic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] synonym: "C5L2 anaphylatoxin chemotactic receptor ligand" NARROW [] is_a: GO:0031714 ! C5a anaphylatoxin chemotactic receptor binding [Term] id: GO:0031716 name: calcitonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a calcitonin receptor." [GOC:mah, GOC:nln] synonym: "calcitonin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031717 name: cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "cannabinoid receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031718 name: type 1 cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "type 1 cannabinoid receptor ligand" NARROW [] is_a: GO:0031717 ! cannabinoid receptor binding [Term] id: GO:0031719 name: type 2 cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "type 2 cannabinoid receptor ligand" NARROW [] is_a: GO:0031717 ! cannabinoid receptor binding [Term] id: GO:0031720 name: haptoglobin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005515 ! protein binding [Term] id: GO:0031721 name: hemoglobin alpha binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hemoglobin alpha chain." [GOC:mah] is_a: GO:0030492 ! hemoglobin binding [Term] id: GO:0031722 name: hemoglobin beta binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hemoglobin beta chain." [GOC:mah] is_a: GO:0030492 ! hemoglobin binding [Term] id: GO:0031723 name: CXCR4 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CXCR4 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CXCR4 chemokine receptor ligand" NARROW [] synonym: "stromal cell-derived factor 1 receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0031724 name: CXCR5 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CXCR5 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CXCR5 chemokine receptor ligand" NARROW [] synonym: "type 1 Burkitt's lymphoma receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0031725 name: CXCR6 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CXCR6 chemokine receptor." [GOC:mah, GOC:nln] synonym: "bonzo receptor binding" EXACT [] synonym: "CXCR6 chemokine receptor ligand" NARROW [] synonym: "STRL33 receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0031726 name: CCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR1 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR1 chemokine receptor ligand" NARROW [] synonym: "macrophage inflammatory protein-1 alpha receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031727 name: CCR2 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR2 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR2 chemokine receptor ligand" NARROW [] synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031728 name: CCR3 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR3 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR3 chemokine receptor ligand" NARROW [] synonym: "eosinophil eotaxin receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031729 name: CCR4 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR4 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR4 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031730 name: CCR5 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR5 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR5 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031731 name: CCR6 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR6 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR6 chemokine receptor ligand" NARROW [] synonym: "LARC receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031732 name: CCR7 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR7 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR7 chemokine receptor ligand" NARROW [] synonym: "MIP-3 beta receptor binding" EXACT [] synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031733 name: CCR8 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR8 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR8 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031734 name: CCR9 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR9 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR9 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031735 name: CCR10 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR10 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR10 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031736 name: CCR11 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR11 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR11 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031737 name: CX3C chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CX3C chemokine receptor." [GOC:mah, GOC:nln] synonym: "CX3C chemokine receptor ligand" NARROW [] synonym: "fractalkine receptor binding" EXACT [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031738 name: XCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a XCR1 chemokine receptor." [GOC:mah, GOC:nln] synonym: "lymphotactin receptor binding" EXACT [] synonym: "XCR1 chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0031739 name: cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "cholecystokinin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031740 name: type A cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type A cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "type A cholecystokinin receptor ligand" NARROW [] is_a: GO:0031739 ! cholecystokinin receptor binding [Term] id: GO:0031741 name: type B gastrin/cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type B gastrin/cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "type B gastrin/cholecystokinin receptor ligand" NARROW [] is_a: GO:0031739 ! cholecystokinin receptor binding [Term] id: GO:0031745 name: cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "cysteinyl leukotriene receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031746 name: type 1 cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "type 1 cysteinyl leukotriene receptor ligand" NARROW [] is_a: GO:0031745 ! cysteinyl leukotriene receptor binding [Term] id: GO:0031747 name: type 2 cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "type 2 cysteinyl leukotriene receptor ligand" NARROW [] is_a: GO:0031745 ! cysteinyl leukotriene receptor binding [Term] id: GO:0031748 name: D1 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D1 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D1 dopamine receptor ligand" NARROW [] synonym: "D1A dopamine receptor binding" EXACT [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031749 name: D2 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D2 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D2 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031750 name: D3 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D3 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D3 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031751 name: D4 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D4 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D4 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031752 name: D5 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D5 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D1B dopamine receptor binding" EXACT [] synonym: "D5 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031753 name: endothelial differentiation G-protein coupled receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endothelial differentiation G-protein coupled receptor." [GOC:mah, GOC:nln] synonym: "endothelial differentiation G-protein coupled receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031754 name: Edg-1 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-1 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-1 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding [Term] id: GO:0031755 name: Edg-2 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-2 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA1 receptor binding" EXACT [] is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding [Term] id: GO:0031756 name: Edg-3 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-3 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-3 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding [Term] id: GO:0031757 name: Edg-4 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-4 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-4 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA2 receptor binding" EXACT [] is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding [Term] id: GO:0031758 name: Edg-5 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-5 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-5 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding [Term] id: GO:0031759 name: Edg-6 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-6 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-6 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding [Term] id: GO:0031760 name: Edg-7 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-7 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-7 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA3 receptor binding" EXACT [] is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding [Term] id: GO:0031761 name: fMet-Leu-Phe receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln] synonym: "fMet-Leu-Phe receptor ligand" NARROW [] synonym: "N-formyl peptide receptor binding" EXACT [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031762 name: follicle-stimulating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a follicle-stimulating hormone receptor." [GOC:mah, GOC:nln] synonym: "follicle stimulating hormone receptor binding" EXACT [] synonym: "follicle stimulating hormone receptor ligand" NARROW [] synonym: "FSH receptor binding" EXACT [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031763 name: galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a galanin receptor." [GOC:mah, GOC:nln] synonym: "galanin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031764 name: type 1 galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 1 galanin receptor ligand" NARROW [] is_a: GO:0031763 ! galanin receptor binding [Term] id: GO:0031765 name: type 2 galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 2 galanin receptor ligand" NARROW [] is_a: GO:0031763 ! galanin receptor binding [Term] id: GO:0031766 name: type 3 galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 3 galanin receptor ligand" NARROW [] is_a: GO:0031763 ! galanin receptor binding [Term] id: GO:0031767 name: gastric inhibitory polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a gastric inhibitory polypeptide receptor." [GOC:mah, GOC:nln] synonym: "gastric inhibitory polypeptide receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031768 name: ghrelin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ghrelin receptor." [GOC:mah, GOC:nln] synonym: "ghrelin receptor ligand" NARROW [] synonym: "type 1 growth hormone secretagogue GH-releasing peptide receptor binding" EXACT [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031769 name: glucagon receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glucagon receptor." [GOC:mah, GOC:nln] synonym: "glucagon receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031770 name: growth hormone-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor." [GOC:mah, GOC:nln] synonym: "growth hormone-releasing hormone receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031771 name: type 1 hypocretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 hypocretin receptor." [GOC:mah, GOC:nln] synonym: "type 1 hypocretin receptor ligand" NARROW [] synonym: "type 1 orexin receptor binding" EXACT [] is_a: GO:0042324 ! hypocretin receptor binding [Term] id: GO:0031772 name: type 2 hypocretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 hypocretin receptor." [GOC:mah, GOC:nln] synonym: "type 2 hypocretin receptor ligand" NARROW [] synonym: "type 2 orexin receptor binding" EXACT [] is_a: GO:0042324 ! hypocretin receptor binding [Term] id: GO:0031773 name: kisspeptin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kisspeptin receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled receptor 54 binding" EXACT [] synonym: "hOT7T175 receptor binding" EXACT [] synonym: "hypogonadotropin-1 receptor binding" EXACT [] synonym: "KiSS-1 receptor binding" EXACT [] synonym: "kisspeptin receptor ligand" NARROW [] synonym: "metastin receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031774 name: leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a leukotriene receptor." [GOC:mah, GOC:nln] synonym: "leukotriene receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031775 name: lutropin-choriogonadotropic hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lutropin-choriogonadotropic hormone receptor." [GOC:mah, GOC:nln] synonym: "lutropin-choriogonadotropic hormone receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031776 name: melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "melanin-concentrating hormone receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031777 name: type 1 melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "type 1 melanin-concentrating hormone receptor ligand" NARROW [] is_a: GO:0031776 ! melanin-concentrating hormone receptor binding [Term] id: GO:0031778 name: type 2 melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "type 2 melanin-concentrating hormone receptor ligand" NARROW [] is_a: GO:0031776 ! melanin-concentrating hormone receptor binding [Term] id: GO:0031779 name: melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a melanocortin receptor." [GOC:mah, GOC:nln] synonym: "melanocortin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031780 name: corticotropin hormone receptor binding namespace: molecular_function alt_id: GO:0071856 def: "Interacting selectively and non-covalently with a corticotropin hormone receptor." [GOC:dph, GOC:mah, GOC:nln] synonym: "ACTH receptor binding" EXACT [] synonym: "adrenocorticotropic hormone receptor ligand" NARROW [] synonym: "adrenocorticotropin hormone receptor binding" EXACT [GOC:dph, GOC:tb] synonym: "adrenocorticotropin receptor binding" EXACT [GOC:dph] synonym: "corticotropin receptor binding" EXACT [GOC:bf] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031781 name: type 3 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 3 melanocortin receptor ligand" NARROW [] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031782 name: type 4 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 4 melanocortin receptor ligand" NARROW [] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031783 name: type 5 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 5 melanocortin receptor ligand" NARROW [] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031784 name: melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a melatonin receptor." [GOC:mah, GOC:nln] synonym: "melatonin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031785 name: type 1A melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1A melatonin receptor." [GOC:mah, GOC:nln] synonym: "type 1A melatonin receptor ligand" NARROW [] is_a: GO:0031784 ! melatonin receptor binding [Term] id: GO:0031786 name: type 1B melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1B melatonin receptor." [GOC:mah, GOC:nln] synonym: "type 1B melatonin receptor ligand" NARROW [] is_a: GO:0031784 ! melatonin receptor binding [Term] id: GO:0031787 name: H9 melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H9 melatonin receptor." [GOC:mah, GOC:nln] synonym: "H9 melatonin receptor ligand" NARROW [] is_a: GO:0031784 ! melatonin receptor binding [Term] id: GO:0031788 name: motilin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a motilin receptor." [GOC:mah, GOC:nln] synonym: "motilin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031789 name: muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "muscarinic acetylcholine receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031790 name: M1 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a M1 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M1 muscarinic acetylcholine receptor ligand" NARROW [] is_a: GO:0031789 ! muscarinic acetylcholine receptor binding [Term] id: GO:0031791 name: M2 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a M2 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M2 muscarinic acetylcholine receptor ligand" NARROW [] is_a: GO:0031789 ! muscarinic acetylcholine receptor binding [Term] id: GO:0031792 name: M3 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a M3 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M3 muscarinic acetylcholine receptor ligand" NARROW [] is_a: GO:0031789 ! muscarinic acetylcholine receptor binding [Term] id: GO:0031793 name: M4 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a M4 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M4 muscarinic acetylcholine receptor ligand" NARROW [] is_a: GO:0031789 ! muscarinic acetylcholine receptor binding [Term] id: GO:0031794 name: M5 muscarinic acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a M5 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] synonym: "M5 muscarinic acetylcholine receptor ligand" NARROW [] is_a: GO:0031789 ! muscarinic acetylcholine receptor binding [Term] id: GO:0031795 name: metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "GABAB receptor binding" EXACT [] synonym: "metabotropic GABA receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031796 name: type 1 metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "type 1 metabotropic GABA receptor ligand" NARROW [] is_a: GO:0031795 ! metabotropic GABA receptor binding [Term] id: GO:0031797 name: type 2 metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "type 2 metabotropic GABA receptor ligand" NARROW [] is_a: GO:0031795 ! metabotropic GABA receptor binding [Term] id: GO:0031798 name: type 1 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 1 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! metabotropic glutamate receptor binding [Term] id: GO:0031799 name: type 2 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 2 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! metabotropic glutamate receptor binding [Term] id: GO:0031800 name: type 3 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 3 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! metabotropic glutamate receptor binding [Term] id: GO:0031801 name: type 4 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 4 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! metabotropic glutamate receptor binding [Term] id: GO:0031802 name: type 5 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 5 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! metabotropic glutamate receptor binding [Term] id: GO:0031803 name: type 6 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 6 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 6 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! metabotropic glutamate receptor binding [Term] id: GO:0031804 name: type 7 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 7 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 7 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! metabotropic glutamate receptor binding [Term] id: GO:0031805 name: type 8 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 8 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 8 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! metabotropic glutamate receptor binding [Term] id: GO:0031806 name: metabotropic histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a metabotropic histamine receptor." [GOC:mah, GOC:nln] synonym: "metabotropic histamine receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031807 name: H1 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H1 histamine receptor." [GOC:mah, GOC:nln] synonym: "H1 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! metabotropic histamine receptor binding [Term] id: GO:0031808 name: H2 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H2 histamine receptor." [GOC:mah, GOC:nln] synonym: "H2 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! metabotropic histamine receptor binding [Term] id: GO:0031809 name: H3 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H3 histamine receptor." [GOC:mah, GOC:nln] synonym: "H3 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! metabotropic histamine receptor binding [Term] id: GO:0031810 name: H4 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H4 histamine receptor." [GOC:mah, GOC:nln] synonym: "H4 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! metabotropic histamine receptor binding [Term] id: GO:0031811 name: metabotropic nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a metabotropic nucleotide receptor." [GOC:mah, GOC:nln] synonym: "metabotropic nucleotide receptor ligand" NARROW [] synonym: "P2Y receptor binding" EXACT [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031812 name: P2Y1 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y1 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y1 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! metabotropic nucleotide receptor binding [Term] id: GO:0031813 name: P2Y2 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y2 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y2 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! metabotropic nucleotide receptor binding [Term] id: GO:0031814 name: P2Y4 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y4 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y4 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! metabotropic nucleotide receptor binding [Term] id: GO:0031815 name: P2Y5 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y5 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y5 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! metabotropic nucleotide receptor binding [Term] id: GO:0031816 name: P2Y6 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y6 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y6 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! metabotropic nucleotide receptor binding [Term] id: GO:0031817 name: P2Y8 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y8 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y8 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! metabotropic nucleotide receptor binding [Term] id: GO:0031818 name: P2Y9 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y9 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y9 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! metabotropic nucleotide receptor binding [Term] id: GO:0031819 name: P2Y10 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y10 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y10 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! metabotropic nucleotide receptor binding [Term] id: GO:0031820 name: P2Y11 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y11 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y11 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! metabotropic nucleotide receptor binding [Term] id: GO:0031821 name: metabotropic serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a metabotropic serotonin receptor." [GOC:mah, GOC:nln] synonym: "metabotropic 5-hydroxytryptamine receptor binding" EXACT [] synonym: "metabotropic serotonin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031822 name: type 1B serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1B receptor binding" EXACT [] synonym: "type 1B serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031823 name: type 1D serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1D serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1D receptor binding" EXACT [] synonym: "type 1D serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031824 name: type 1E serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1E serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1E receptor binding" EXACT [] synonym: "type 1E serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031825 name: type 1F serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1F serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1F receptor binding" EXACT [] synonym: "type 1F serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031826 name: type 2A serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2A serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2A receptor binding" EXACT [] synonym: "type 2A serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031827 name: type 2B serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2B receptor binding" EXACT [] synonym: "type 2B serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031828 name: type 2C serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2C serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2C receptor binding" EXACT [] synonym: "type 2C serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031829 name: type 4 serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 4 receptor binding" EXACT [] synonym: "type 4 serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031830 name: type 5A serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5A serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 5A receptor binding" EXACT [] synonym: "type 5A serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031831 name: type 5B serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 5B receptor binding" EXACT [] synonym: "type 5B serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031832 name: type 6 serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 6 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 6 receptor binding" EXACT [] synonym: "type 6 serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031833 name: type 7 serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 7 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 7 receptor binding" EXACT [] synonym: "type 7 serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! metabotropic serotonin receptor binding [Term] id: GO:0031834 name: neurokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurokinin receptor." [GOC:mah, GOC:nln] synonym: "neurokinin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031835 name: substance P receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a substance P receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-1 receptor binding" EXACT [] synonym: "substance P receptor ligand" NARROW [] is_a: GO:0031834 ! neurokinin receptor binding [Term] id: GO:0031836 name: neuromedin K receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuromedin K receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-B receptor binding" EXACT [] synonym: "neuromedin K receptor ligand" NARROW [] is_a: GO:0031834 ! neurokinin receptor binding [Term] id: GO:0031837 name: substance K receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a substance K receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-A receptor binding" EXACT [] synonym: "substance K receptor ligand" NARROW [] is_a: GO:0031834 ! neurokinin receptor binding [Term] id: GO:0031838 name: haptoglobin-hemoglobin complex namespace: cellular_component def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah] is_a: GO:0043234 ! protein complex [Term] id: GO:0031839 name: type 1 neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 neuromedin U receptor." [GOC:mah, GOC:nln] synonym: "type 1 neuromedin U receptor ligand" NARROW [] is_a: GO:0042922 ! neuromedin U receptor binding [Term] id: GO:0031840 name: type 2 neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 neuromedin U receptor." [GOC:mah, GOC:nln] synonym: "type 2 neuromedin U receptor ligand" NARROW [] is_a: GO:0042922 ! neuromedin U receptor binding [Term] id: GO:0031841 name: neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "neuropeptide Y receptor ligand" NARROW [] synonym: "NPY receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031842 name: type 1 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 1 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031843 name: type 2 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 2 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031844 name: type 4 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "pancreatic polypeptide receptor binding" EXACT [] synonym: "type 4 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031845 name: type 5 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 5 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031846 name: neurotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotensin receptor." [GOC:mah, GOC:nln] synonym: "neurotensin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031847 name: type 1 neurotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 neurotensin receptor." [GOC:mah, GOC:nln] synonym: "type 1 neurotensin receptor ligand" NARROW [] is_a: GO:0031846 ! neurotensin receptor binding [Term] id: GO:0031848 name: protection from non-homologous end joining at telomere namespace: biological_process def: "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse." [GOC:mah] synonym: "protection from NHEJ-mediated telomere fusion" EXACT [] is_a: GO:0043247 ! telomere maintenance in response to DNA damage relationship: part_of GO:0016233 ! telomere capping [Term] id: GO:0031849 name: olfactory receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an olfactory receptor." [GOC:mah, GOC:nln] synonym: "olfactory receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031850 name: delta-type opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a delta-type opioid receptor." [GOC:mah, GOC:nln] synonym: "delta-type opioid receptor ligand" NARROW [] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031851 name: kappa-type opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kappa-type opioid receptor." [GOC:mah, GOC:nln] synonym: "kappa-type opioid receptor ligand" NARROW [] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031852 name: mu-type opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mu-type opioid receptor." [GOC:mah, GOC:nln] synonym: "mu-type opioid receptor ligand" NARROW [] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031853 name: nociceptin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nociceptin receptor." [GOC:mah, GOC:nln] synonym: "nociceptin receptor ligand" NARROW [] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031854 name: orexigenic neuropeptide QRFP receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an orexigenic neuropeptide QRFP receptor." [GOC:mah, GOC:nln] synonym: "orexigenic neuropeptide QRFP receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031855 name: oxytocin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an oxytocin receptor." [GOC:mah, GOC:nln] synonym: "oxytocin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031856 name: parathyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a parathyroid hormone receptor." [GOC:mah, GOC:nln] synonym: "parathyroid hormone receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031857 name: type 1 parathyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor." [GOC:mah, GOC:nln] synonym: "type 1 parathyroid hormone receptor ligand" NARROW [] is_a: GO:0031856 ! parathyroid hormone receptor binding [Term] id: GO:0031858 name: pituitary adenylate cyclase-activating polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pituitary adenylate cyclase-activating polypeptide receptor." [GOC:mah, GOC:nln] synonym: "PACAP receptor binding" EXACT [] synonym: "pituitary adenylate cyclase activating peptide receptor binding" EXACT [GOC:dph, GOC:tb] synonym: "pituitary adenylate cyclase-activating peptide receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031859 name: platelet activating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a platelet activating factor receptor." [GOC:mah, GOC:nln] synonym: "platelet activating factor receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031860 name: telomeric 3' overhang formation namespace: biological_process def: "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639] synonym: "telomere 3'-end processing" EXACT [GOC:mah, GOC:vw] synonym: "telomere end processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0022616 ! DNA strand elongation relationship: part_of GO:0016233 ! telomere capping [Term] id: GO:0031861 name: prolactin-releasing peptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prolactin-releasing peptide receptor." [GOC:mah, GOC:nln] synonym: "prolactin-releasing peptide receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031862 name: prostanoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostanoid receptor." [GOC:mah, GOC:nln] synonym: "prostanoid receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031863 name: prostaglandin D2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostaglandin D2 receptor." [GOC:mah, GOC:nln] synonym: "prostaglandin D2 receptor ligand" NARROW [] synonym: "prostanoid DP receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031864 name: EP1 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP1 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP1 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP1 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031865 name: EP2 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP2 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP2 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP2 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031866 name: EP3 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP3 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP3 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP3 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031867 name: EP4 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP4 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP4 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP4 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031868 name: prostaglandin F2-alpha receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostaglandin F2-alpha receptor." [GOC:mah, GOC:nln] synonym: "prostaglandin F2-alpha receptor ligand" NARROW [] synonym: "prostanoid FP receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031869 name: prostacyclin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostacyclin receptor." [GOC:mah, GOC:nln] synonym: "prostacyclin receptor ligand" NARROW [] synonym: "prostanoid IP receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031870 name: thromboxane A2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a thromboxane A2 receptor." [GOC:mah, GOC:nln] synonym: "prostanoid TP receptor binding" EXACT [] synonym: "thromboxane A2 receptor ligand" NARROW [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031871 name: proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "proteinase activated receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031872 name: type 1 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "thrombin receptor binding" EXACT [] synonym: "type 1 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031873 name: type 2 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 2 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031874 name: type 3 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 3 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031875 name: type 4 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 4 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031876 name: secretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a secretin receptor." [GOC:mah, GOC:nln] synonym: "secretin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031877 name: somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a somatostatin receptor." [GOC:mah, GOC:nln] synonym: "somatostatin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031878 name: type 1 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 1 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031879 name: type 2 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 2 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031880 name: type 3 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 3 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031881 name: type 4 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 4 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031882 name: type 5 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 5 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031883 name: taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a taste receptor." [GOC:mah, GOC:nln] synonym: "taste receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031884 name: type 1 member 1 taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 member 1 taste receptor." [GOC:mah, GOC:nln] synonym: "type 1 member 1 taste receptor ligand" NARROW [] is_a: GO:0031883 ! taste receptor binding [Term] id: GO:0031885 name: type 1 member 2 taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 member 2 taste receptor." [GOC:mah, GOC:nln] synonym: "type 1 member 2 taste receptor ligand" NARROW [] is_a: GO:0031883 ! taste receptor binding [Term] id: GO:0031886 name: type 1 member 3 taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 member 3 taste receptor." [GOC:mah, GOC:nln] synonym: "sweet taste receptor binding" EXACT [] synonym: "type 1 member 3 taste receptor ligand" NARROW [] is_a: GO:0031883 ! taste receptor binding [Term] id: GO:0031887 name: lipid particle transport along microtubule namespace: biological_process def: "The directed movement of a lipid particle along a microtubule, mediated by motor proteins." [PMID:9491895] is_a: GO:0010970 ! microtubule-based transport [Term] id: GO:0031889 name: urotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a urotensin receptor." [GOC:mah, GOC:nln] synonym: "urotensin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031890 name: vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "VIP receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031891 name: type 1 vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "type 1 vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "type 2 PACAP receptor binding" EXACT [] is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding [Term] id: GO:0031892 name: type 2 vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "type 2 vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "type 3 PACAP receptor binding" EXACT [] is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding [Term] id: GO:0031893 name: vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vasopressin receptor." [GOC:mah, GOC:nln] synonym: "vasopressin receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0031894 name: V1A vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a V1A vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V1A vasopressin receptor ligand" NARROW [] is_a: GO:0031893 ! vasopressin receptor binding [Term] id: GO:0031895 name: V1B vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a V1B vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V1B vasopressin receptor ligand" NARROW [] is_a: GO:0031893 ! vasopressin receptor binding [Term] id: GO:0031896 name: V2 vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a V2 vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V2 vasopressin receptor ligand" NARROW [] is_a: GO:0031893 ! vasopressin receptor binding [Term] id: GO:0031897 name: Tic complex namespace: cellular_component def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016] synonym: "chloroplast inner membrane translocase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009706 ! chloroplast inner membrane [Term] id: GO:0031898 name: chromoplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009509 ! chromoplast [Term] id: GO:0031899 name: chromoplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0046862 ! chromoplast membrane [Term] id: GO:0031900 name: chromoplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0046862 ! chromoplast membrane [Term] id: GO:0031901 name: early endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an early endosome." [GOC:pz] is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0005769 ! early endosome [Term] id: GO:0031902 name: late endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a late endosome." [GOC:pz] is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0005770 ! late endosome [Term] id: GO:0031903 name: microbody membrane namespace: cellular_component def: "The lipid bilayer surrounding a microbody." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0042579 ! microbody [Term] id: GO:0031904 name: endosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an endosome." [GOC:mah] xref: NIF_Subcellular:sao1547508851 is_a: GO:0044440 ! endosomal part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0031905 name: early endosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an early endosome." [GOC:mah] is_a: GO:0031904 ! endosome lumen relationship: part_of GO:0005769 ! early endosome [Term] id: GO:0031906 name: late endosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of a late endosome." [GOC:mah] is_a: GO:0031904 ! endosome lumen relationship: part_of GO:0005770 ! late endosome [Term] id: GO:0031907 name: microbody lumen namespace: cellular_component def: "The volume enclosed by the membranes of a microbody." [GOC:mah] is_a: GO:0044438 ! microbody part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0031908 name: glyoxysomal lumen namespace: cellular_component def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah] is_a: GO:0005782 ! peroxisomal matrix [Term] id: GO:0031910 name: cytostome namespace: cellular_component def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189] xref: Wikipedia:Cytostome is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0031911 name: cytoproct namespace: cellular_component def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0031912 name: oral apparatus namespace: cellular_component def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189] comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals. is_a: GO:0042995 ! cell projection [Term] id: GO:0031913 name: contractile vacuole pore namespace: cellular_component def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0044437 ! vacuolar part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005884 ! actin filament relationship: part_of GO:0031164 ! contractile vacuolar membrane [Term] id: GO:0031914 name: negative regulation of synaptic plasticity namespace: biological_process def: "A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] synonym: "down regulation of synaptic plasticity" EXACT [] synonym: "down-regulation of synaptic plasticity" EXACT [] synonym: "downregulation of synaptic plasticity" EXACT [] synonym: "inhibition of synaptic plasticity" NARROW [] is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0031915 name: positive regulation of synaptic plasticity namespace: biological_process def: "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] synonym: "activation of synaptic plasticity" NARROW [] synonym: "stimulation of synaptic plasticity" NARROW [] synonym: "up regulation of synaptic plasticity" EXACT [] synonym: "up-regulation of synaptic plasticity" EXACT [] synonym: "upregulation of synaptic plasticity" EXACT [] is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0031916 name: regulation of synaptic metaplasticity namespace: biological_process def: "A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0031917 name: negative regulation of synaptic metaplasticity namespace: biological_process def: "A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] synonym: "down regulation of synaptic metaplasticity" EXACT [] synonym: "down-regulation of synaptic metaplasticity" EXACT [] synonym: "downregulation of synaptic metaplasticity" EXACT [] synonym: "inhibition of synaptic metaplasticity" NARROW [] is_a: GO:0031914 ! negative regulation of synaptic plasticity is_a: GO:0031916 ! regulation of synaptic metaplasticity [Term] id: GO:0031918 name: positive regulation of synaptic metaplasticity namespace: biological_process def: "A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] synonym: "activation of synaptic metaplasticity" NARROW [] synonym: "stimulation of synaptic metaplasticity" NARROW [] synonym: "up regulation of synaptic metaplasticity" EXACT [] synonym: "up-regulation of synaptic metaplasticity" EXACT [] synonym: "upregulation of synaptic metaplasticity" EXACT [] is_a: GO:0031915 ! positive regulation of synaptic plasticity is_a: GO:0031916 ! regulation of synaptic metaplasticity [Term] id: GO:0031919 name: vitamin B6 transport namespace: biological_process def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0035461 ! vitamin transmembrane transport [Term] id: GO:0031920 name: pyridoxal transport namespace: biological_process def: "The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0031919 ! vitamin B6 transport [Term] id: GO:0031921 name: pyridoxal phosphate transport namespace: biological_process def: "The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] is_a: GO:0031919 ! vitamin B6 transport [Term] id: GO:0031922 name: pyridoxamine transport namespace: biological_process def: "The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0031919 ! vitamin B6 transport [Term] id: GO:0031923 name: pyridoxine transport namespace: biological_process def: "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0031919 ! vitamin B6 transport [Term] id: GO:0031924 name: vitamin B6 transporter activity namespace: molecular_function def: "Enables the directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells." [GOC:mah] is_a: GO:0051183 ! vitamin transporter activity [Term] id: GO:0031925 name: pyridoxal transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pyridoxal across a membrane into, out of or within a cell, or between cells. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxal transporter activity" BROAD [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transporter activity [Term] id: GO:0031926 name: pyridoxal phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pyridoxal phosphate into, out of or within a cell, or between cells; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transporter activity [Term] id: GO:0031927 name: pyridoxamine transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pyridoxamine into, out of or within a cell, or between cells. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transporter activity [Term] id: GO:0031928 name: pyridoxine transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pyridoxine across a membrane into, out of or within a cell, or between cells. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxine transporter activity" BROAD [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transporter activity [Term] id: GO:0031929 name: TOR signaling cascade namespace: biological_process def: "A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] comment: Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'. synonym: "target of rapamycin signaling pathway" EXACT [] synonym: "target of rapamycin signalling pathway" EXACT [] synonym: "TOR signaling pathway" EXACT [] synonym: "TOR signalling pathway" EXACT [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0031930 name: mitochondria-nucleus signaling pathway namespace: biological_process def: "A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function." [GOC:jh, PMID:15068799] synonym: "mitochondrial signaling pathway" EXACT [] synonym: "mitochondrial signalling pathway" EXACT [] synonym: "retrograde response" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0031931 name: TORC1 complex namespace: cellular_component def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p; in mammals the complex contains orthologs of the yeast proteins." [GOC:jh, PMID:15780592] synonym: "nutrient sensitive complex" EXACT [] synonym: "TOR complex 1" EXACT [] synonym: "TORC 1 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031932 name: TORC2 complex namespace: cellular_component def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates spatial control of cell growth via regulation of actin cytoskeleton polarization. In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p; in mammals the complex contains orthologs of the yeast proteins." [GOC:jh, PMID:14736892, PMID:15780592] synonym: "TOR complex 2" EXACT [] synonym: "TORC 2 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031933 name: telomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah] is_a: GO:0000792 ! heterochromatin relationship: part_of GO:0000781 ! chromosome, telomeric region [Term] id: GO:0031934 name: mating-type region heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah] is_a: GO:0000792 ! heterochromatin [Term] id: GO:0031935 name: regulation of chromatin silencing namespace: biological_process def: "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] synonym: "regulation of heterochromatic silencing" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0060968 ! regulation of gene silencing relationship: regulates GO:0006342 ! chromatin silencing [Term] id: GO:0031936 name: negative regulation of chromatin silencing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah] synonym: "down regulation of chromatin silencing" EXACT [] synonym: "down-regulation of chromatin silencing" EXACT [] synonym: "downregulation of chromatin silencing" EXACT [] synonym: "inhibition of chromatin silencing" NARROW [] synonym: "negative regulation of heterochromatic silencing" EXACT [] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:0045815 ! positive regulation of gene expression, epigenetic is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent is_a: GO:0060969 ! negative regulation of gene silencing relationship: negatively_regulates GO:0006342 ! chromatin silencing [Term] id: GO:0031937 name: positive regulation of chromatin silencing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing." [GOC:mah] synonym: "activation of chromatin silencing" NARROW [] synonym: "positive regulation of heterochromatic silencing" EXACT [] synonym: "stimulation of chromatin silencing" NARROW [] synonym: "up regulation of chromatin silencing" EXACT [] synonym: "up-regulation of chromatin silencing" EXACT [] synonym: "upregulation of chromatin silencing" EXACT [] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0006342 ! chromatin silencing [Term] id: GO:0031938 name: regulation of chromatin silencing at telomere namespace: biological_process def: "Any process that affects the rate, extent or location of chromatin silencing at telomeres." [GOC:mah] synonym: "regulation of heterochromatic silencing at telomere" EXACT [] is_a: GO:0031935 ! regulation of chromatin silencing relationship: regulates GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0031939 name: negative regulation of chromatin silencing at telomere namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] synonym: "down regulation of chromatin silencing at telomere" EXACT [] synonym: "down-regulation of chromatin silencing at telomere" EXACT [] synonym: "downregulation of chromatin silencing at telomere" EXACT [] synonym: "inhibition of chromatin silencing at telomere" NARROW [] synonym: "negative regulation of heterochromatic silencing at telomere" EXACT [] is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0031938 ! regulation of chromatin silencing at telomere relationship: negatively_regulates GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0031940 name: positive regulation of chromatin silencing at telomere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] synonym: "activation of chromatin silencing at telomere" NARROW [] synonym: "positive regulation of heterochromatic silencing at telomere" EXACT [] synonym: "stimulation of chromatin silencing at telomere" NARROW [] synonym: "up regulation of chromatin silencing at telomere" EXACT [] synonym: "up-regulation of chromatin silencing at telomere" EXACT [] synonym: "upregulation of chromatin silencing at telomere" EXACT [] is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0031938 ! regulation of chromatin silencing at telomere relationship: positively_regulates GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0031941 name: filamentous actin namespace: cellular_component def: "A two-stranded helical polymer of the protein actin." [GOC:mah] comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'. synonym: "F-actin" EXACT [] xref: Wikipedia:Actin is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005884 ! actin filament [Term] id: GO:0031942 name: i-AAA complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0031943 name: regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "regulation of glucocorticoid metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: regulates GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0031944 name: negative regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid metabolic process" EXACT [] synonym: "down-regulation of glucocorticoid metabolic process" EXACT [] synonym: "downregulation of glucocorticoid metabolic process" EXACT [] synonym: "inhibition of glucocorticoid metabolic process" NARROW [] synonym: "negative regulation of glucocorticoid metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process relationship: negatively_regulates GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0031945 name: positive regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid metabolic process" NARROW [] synonym: "positive regulation of glucocorticoid metabolism" EXACT [] synonym: "stimulation of glucocorticoid metabolic process" NARROW [] synonym: "up regulation of glucocorticoid metabolic process" EXACT [] synonym: "up-regulation of glucocorticoid metabolic process" EXACT [] synonym: "upregulation of glucocorticoid metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process relationship: positively_regulates GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0031946 name: regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process relationship: regulates GO:0006704 ! glucocorticoid biosynthetic process [Term] id: GO:0031947 name: negative regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "downregulation of glucocorticoid biosynthetic process" EXACT [] synonym: "inhibition of glucocorticoid biosynthetic process" NARROW [] is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process relationship: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process [Term] id: GO:0031948 name: positive regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid biosynthetic process" NARROW [] synonym: "stimulation of glucocorticoid biosynthetic process" NARROW [] synonym: "up regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "upregulation of glucocorticoid biosynthetic process" EXACT [] is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process relationship: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process [Term] id: GO:0031949 name: regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process relationship: regulates GO:0006713 ! glucocorticoid catabolic process [Term] id: GO:0031950 name: negative regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid catabolic process" EXACT [] synonym: "down-regulation of glucocorticoid catabolic process" EXACT [] synonym: "downregulation of glucocorticoid catabolic process" EXACT [] synonym: "inhibition of glucocorticoid catabolic process" NARROW [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process is_a: GO:0031949 ! regulation of glucocorticoid catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process relationship: negatively_regulates GO:0006713 ! glucocorticoid catabolic process [Term] id: GO:0031951 name: positive regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid catabolic process" NARROW [] synonym: "stimulation of glucocorticoid catabolic process" NARROW [] synonym: "up regulation of glucocorticoid catabolic process" EXACT [] synonym: "up-regulation of glucocorticoid catabolic process" EXACT [] synonym: "upregulation of glucocorticoid catabolic process" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process is_a: GO:0031949 ! regulation of glucocorticoid catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process relationship: positively_regulates GO:0006713 ! glucocorticoid catabolic process [Term] id: GO:0031952 name: regulation of protein autophosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation relationship: regulates GO:0046777 ! protein autophosphorylation [Term] id: GO:0031953 name: negative regulation of protein autophosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "down regulation of protein amino acid autophosphorylation" EXACT [] synonym: "down-regulation of protein amino acid autophosphorylation" EXACT [] synonym: "downregulation of protein amino acid autophosphorylation" EXACT [] synonym: "inhibition of protein amino acid autophosphorylation" NARROW [] synonym: "negative regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0031952 ! regulation of protein autophosphorylation relationship: negatively_regulates GO:0046777 ! protein autophosphorylation [Term] id: GO:0031954 name: positive regulation of protein autophosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "activation of protein amino acid autophosphorylation" NARROW [] synonym: "positive regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid autophosphorylation" NARROW [] synonym: "up regulation of protein amino acid autophosphorylation" EXACT [] synonym: "up-regulation of protein amino acid autophosphorylation" EXACT [] synonym: "upregulation of protein amino acid autophosphorylation" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0031952 ! regulation of protein autophosphorylation relationship: positively_regulates GO:0046777 ! protein autophosphorylation [Term] id: GO:0031955 name: short-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids have chain lengths of less than 8 carbons." [EC:6.2.1.3, GOC:mah] synonym: "short-chain fatty acid activation" RELATED [] synonym: "short-chain fatty acid-CoA ligase activity" EXACT [] synonym: "short-chain-fatty-acid-CoA ligase activity" EXACT [] is_a: GO:0015645 ! fatty acid ligase activity [Term] id: GO:0031956 name: medium-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; medium-chain fatty acids have chain lengths of C8-12." [EC:6.2.1.3, GOC:mah] synonym: "medium-chain fatty acid activation" RELATED [] synonym: "medium-chain fatty acid-CoA ligase activity" EXACT [] synonym: "medium-chain-fatty-acid-CoA ligase activity" EXACT [] is_a: GO:0015645 ! fatty acid ligase activity [Term] id: GO:0031957 name: very long-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18." [EC:6.2.1.3, GOC:mah] synonym: "very-long-chain fatty acid activation" RELATED [] synonym: "very-long-chain fatty acid-CoA ligase activity" EXACT [] synonym: "very-long-chain-fatty-acid-CoA ligase activity" EXACT [] is_a: GO:0015645 ! fatty acid ligase activity [Term] id: GO:0031958 name: corticosteroid receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] synonym: "corticosteroid receptor signalling pathway" EXACT [] is_a: GO:0030518 ! steroid hormone receptor signaling pathway [Term] id: GO:0031959 name: mineralocorticoid receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] synonym: "mineralocorticoid receptor signalling pathway" EXACT [] is_a: GO:0031958 ! corticosteroid receptor signaling pathway [Term] id: GO:0031960 name: response to corticosteroid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914] is_a: GO:0048545 ! response to steroid hormone stimulus [Term] id: GO:0031961 name: cortisol receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cortisol receptor." [GOC:mah, PMID:12511169] is_a: GO:0035259 ! glucocorticoid receptor binding [Term] id: GO:0031962 name: mineralocorticoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mineralocorticoid receptor." [GOC:mah, PMID:12511169] is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0031963 name: cortisol receptor activity namespace: molecular_function def: "Combining with cortisol to initiate a change in cell activity." [GOC:mah, PMID:12511169] is_a: GO:0004883 ! glucocorticoid receptor activity [Term] id: GO:0031964 name: beta-alanyl-histamine hydrolase activity namespace: molecular_function def: "Catalysis of the conversion of beta-alanyl-histamine to histamine." [GOC:rc, PMID:16299587] synonym: "carcinine hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0031965 name: nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] xref: NIF_Subcellular:sao1687101204 is_a: GO:0031090 ! organelle membrane is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0031966 name: mitochondrial membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0031967 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: gosubset_prok is_a: GO:0031975 ! envelope is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031968 name: organelle outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] is_a: GO:0019867 ! outer membrane is_a: GO:0031090 ! organelle membrane is_a: GO:0044424 ! intracellular part relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0031969 name: chloroplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz] xref: Wikipedia:Chloroplast_membrane is_a: GO:0042170 ! plastid membrane is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009941 ! chloroplast envelope [Term] id: GO:0031970 name: organelle envelope lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah] synonym: "organelle intermembrane space" EXACT [] is_a: GO:0031974 ! membrane-enclosed lumen is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0031972 name: chloroplast intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah] synonym: "chloroplast envelope lumen" EXACT [] is_a: GO:0009529 ! plastid intermembrane space is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009941 ! chloroplast envelope [Term] id: GO:0031973 name: chromoplast intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah] synonym: "chromoplast envelope lumen" EXACT [] is_a: GO:0009529 ! plastid intermembrane space relationship: part_of GO:0031898 ! chromoplast envelope [Term] id: GO:0031974 name: membrane-enclosed lumen namespace: cellular_component def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] is_a: GO:0005575 ! cellular_component [Term] id: GO:0031975 name: envelope namespace: cellular_component def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz] subset: gosubset_prok is_a: GO:0044464 ! cell part [Term] id: GO:0031976 name: plastid thylakoid namespace: cellular_component def: "Any thylakoid within a plastid." [GOC:pz] is_a: GO:0009579 ! thylakoid is_a: GO:0031984 ! organelle subcompartment is_a: GO:0044435 ! plastid part [Term] id: GO:0031977 name: thylakoid lumen namespace: cellular_component def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz] is_a: GO:0044436 ! thylakoid part [Term] id: GO:0031978 name: plastid thylakoid lumen namespace: cellular_component def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah] is_a: GO:0031977 ! thylakoid lumen is_a: GO:0044435 ! plastid part relationship: part_of GO:0031976 ! plastid thylakoid [Term] id: GO:0031979 name: plasma membrane-derived thylakoid lumen namespace: cellular_component def: "The volume enclosed by a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane thylakoid lumen" EXACT [] is_a: GO:0031977 ! thylakoid lumen is_a: GO:0044459 ! plasma membrane part is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid [Term] id: GO:0031981 name: nuclear lumen namespace: cellular_component def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] is_a: GO:0044428 ! nuclear part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0031982 name: vesicle namespace: cellular_component def: "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] subset: goslim_pir subset: gosubset_prok xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043226 ! organelle [Term] id: GO:0031983 name: vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah] xref: NIF_Subcellular:sao797538226 is_a: GO:0043233 ! organelle lumen relationship: part_of GO:0031988 ! membrane-bounded vesicle [Term] id: GO:0031984 name: organelle subcompartment namespace: cellular_component def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles. synonym: "suborganelle compartment" EXACT [] is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031985 name: Golgi cisterna namespace: cellular_component def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah] is_a: GO:0031984 ! organelle subcompartment is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0005795 ! Golgi stack [Term] id: GO:0031986 name: proteinoplast namespace: cellular_component def: "A leucoplast in which protein is stored." [GOC:pz] xref: Wikipedia:Proteinoplast is_a: GO:0009536 ! plastid [Term] id: GO:0031987 name: locomotion involved in locomotory behavior namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] synonym: "locomotion during locomotory behaviour" EXACT [] is_a: GO:0040011 ! locomotion relationship: part_of GO:0007626 ! locomotory behavior [Term] id: GO:0031988 name: membrane-bounded vesicle namespace: cellular_component def: "Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer." [GOC:mah] subset: gosubset_prok synonym: "membrane-enclosed vesicle" EXACT [] is_a: GO:0031982 ! vesicle [Term] id: GO:0031989 name: bombesin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "bombesin receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0031990 name: mRNA export from nucleus in response to heat stress namespace: biological_process def: "The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw] synonym: "mRNA export from cell nucleus during heat stress" EXACT [] synonym: "mRNA export from nucleus during heat stress" RELATED [GOC:dph, GOC:tb] is_a: GO:0006406 ! mRNA export from nucleus is_a: GO:0034605 ! cellular response to heat [Term] id: GO:0031991 name: regulation of contractile ring contraction involved in cell cycle cytokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of contractile ring contraction involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process is_a: GO:0032954 ! regulation of cytokinetic process is_a: GO:0071775 ! regulation of cell cycle cytokinesis relationship: regulates GO:0000916 ! contractile ring contraction involved in cell cycle cytokinesis [Term] id: GO:0031992 name: energy transducer activity namespace: molecular_function def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators] subset: goslim_pir synonym: "light harvesting activity" RELATED [] synonym: "photon capture" RELATED [] is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0031993 name: light transducer activity namespace: molecular_function def: "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell." [GOC:mah, GOC:mlg] is_a: GO:0031992 ! energy transducer activity [Term] id: GO:0031994 name: insulin-like growth factor I binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin-like growth factor I." [GOC:mah] synonym: "IGF-I binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0031995 name: insulin-like growth factor II binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin-like growth factor II." [GOC:mah] synonym: "IGF-II binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0031996 name: thioesterase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any thioesterase enzyme." [GOC:dl] synonym: "thiolesterase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0031997 name: N-terminal myristoylation domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." [GOC:dl, GOC:jsg, PMID:15632291] is_a: GO:0047485 ! protein N-terminus binding [Term] id: GO:0031998 name: regulation of fatty acid beta-oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation." [GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0046320 ! regulation of fatty acid oxidation is_a: GO:0050994 ! regulation of lipid catabolic process relationship: regulates GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0031999 name: negative regulation of fatty acid beta-oxidation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] synonym: "down regulation of fatty acid beta-oxidation" EXACT [] synonym: "down-regulation of fatty acid beta-oxidation" EXACT [] synonym: "downregulation of fatty acid beta-oxidation" EXACT [] synonym: "inhibition of fatty acid beta-oxidation" NARROW [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0031998 ! regulation of fatty acid beta-oxidation is_a: GO:0046322 ! negative regulation of fatty acid oxidation is_a: GO:0050995 ! negative regulation of lipid catabolic process relationship: negatively_regulates GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0032000 name: positive regulation of fatty acid beta-oxidation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] synonym: "activation of fatty acid beta-oxidation" NARROW [] synonym: "stimulation of fatty acid beta-oxidation" NARROW [] synonym: "up regulation of fatty acid beta-oxidation" EXACT [] synonym: "up-regulation of fatty acid beta-oxidation" EXACT [] synonym: "upregulation of fatty acid beta-oxidation" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0031998 ! regulation of fatty acid beta-oxidation is_a: GO:0046321 ! positive regulation of fatty acid oxidation is_a: GO:0050996 ! positive regulation of lipid catabolic process relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0032001 name: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer an alpha-D-glucosyl residue in a 1,4-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a 1,4-alpha-D-glucan." [EC:2.4.1.24] synonym: "1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity" EXACT [] synonym: "D-glucosyltransferase" BROAD [] synonym: "oligoglucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.24] synonym: "T-enzyme" NARROW [] xref: EC:2.4.1.24 xref: MetaCyc:2.4.1.24-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0032002 name: interleukin-28 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-28 and interleukin-29. Composed of two subunits, IL-28R alpha and IL-10R beta." [GOC:rph] synonym: "IL-28 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0032003 name: interleukin-28 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-28 receptor." [GOC:rph] synonym: "IL-28" NARROW [] synonym: "interleukin-28 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0032005 name: regulation of conjugation with cellular fusion by signal transduction namespace: biological_process def: "The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0031137 ! regulation of conjugation with cellular fusion is_a: GO:0048610 ! cellular process involved in reproduction [Term] id: GO:0032006 name: regulation of TOR signaling cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via the TOR signaling pathway." [GOC:mah] synonym: "regulation of target of rapamycin signaling pathway" EXACT [] synonym: "regulation of target of rapamycin signalling pathway" EXACT [] synonym: "regulation of TOR signaling pathway" EXACT [] synonym: "regulation of TOR signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0031929 ! TOR signaling cascade [Term] id: GO:0032007 name: negative regulation of TOR signaling cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the TOR signaling pathway." [GOC:mah] synonym: "down regulation of TOR signaling pathway" EXACT [] synonym: "down-regulation of TOR signaling pathway" EXACT [] synonym: "downregulation of TOR signaling pathway" EXACT [] synonym: "inhibition of TOR signaling pathway" NARROW [] synonym: "negative regulation of target of rapamycin signaling pathway" EXACT [] synonym: "negative regulation of target of rapamycin signalling pathway" EXACT [] synonym: "negative regulation of TOR signaling pathway" EXACT [] synonym: "negative regulation of TOR signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0032006 ! regulation of TOR signaling cascade relationship: negatively_regulates GO:0031929 ! TOR signaling cascade [Term] id: GO:0032008 name: positive regulation of TOR signaling cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the TOR signaling pathway." [GOC:mah] synonym: "activation of TOR signaling pathway" NARROW [] synonym: "positive regulation of target of rapamycin signaling pathway" EXACT [] synonym: "positive regulation of target of rapamycin signalling pathway" EXACT [] synonym: "positive regulation of TOR signaling pathway" EXACT [] synonym: "positive regulation of TOR signalling pathway" EXACT [] synonym: "stimulation of TOR signaling pathway" NARROW [] synonym: "up regulation of TOR signaling pathway" EXACT [] synonym: "up-regulation of TOR signaling pathway" EXACT [] synonym: "upregulation of TOR signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0032006 ! regulation of TOR signaling cascade relationship: positively_regulates GO:0031929 ! TOR signaling cascade [Term] id: GO:0032009 name: early phagosome namespace: cellular_component def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753] synonym: "early phagocytic vesicle" EXACT [] is_a: GO:0045335 ! phagocytic vesicle [Term] id: GO:0032010 name: phagolysosome namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753] synonym: "late phagocytic vesicle" RELATED [] synonym: "late phagosome" RELATED [] xref: Wikipedia:Phagolysosome is_a: GO:0005767 ! secondary lysosome is_a: GO:0045335 ! phagocytic vesicle [Term] id: GO:0032011 name: ARF protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032012 name: regulation of ARF protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0032011 ! ARF protein signal transduction [Term] id: GO:0032013 name: negative regulation of ARF protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] synonym: "down regulation of ARF protein signal transduction" EXACT [] synonym: "down-regulation of ARF protein signal transduction" EXACT [] synonym: "downregulation of ARF protein signal transduction" EXACT [] synonym: "inhibition of ARF protein signal transduction" NARROW [] is_a: GO:0032012 ! regulation of ARF protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction relationship: negatively_regulates GO:0032011 ! ARF protein signal transduction [Term] id: GO:0032014 name: positive regulation of ARF protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] synonym: "activation of ARF protein signal transduction" NARROW [] synonym: "stimulation of ARF protein signal transduction" NARROW [] synonym: "up regulation of ARF protein signal transduction" EXACT [] synonym: "up-regulation of ARF protein signal transduction" EXACT [] synonym: "upregulation of ARF protein signal transduction" EXACT [] is_a: GO:0032012 ! regulation of ARF protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction relationship: positively_regulates GO:0032011 ! ARF protein signal transduction [Term] id: GO:0032015 name: regulation of Ran protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0031291 ! Ran protein signal transduction [Term] id: GO:0032016 name: negative regulation of Ran protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] synonym: "down regulation of Ran protein signal transduction" EXACT [] synonym: "down-regulation of Ran protein signal transduction" EXACT [] synonym: "downregulation of Ran protein signal transduction" EXACT [] synonym: "inhibition of Ran protein signal transduction" NARROW [] is_a: GO:0032015 ! regulation of Ran protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction relationship: negatively_regulates GO:0031291 ! Ran protein signal transduction [Term] id: GO:0032017 name: positive regulation of Ran protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] synonym: "activation of Ran protein signal transduction" NARROW [] synonym: "stimulation of Ran protein signal transduction" NARROW [] synonym: "up regulation of Ran protein signal transduction" EXACT [] synonym: "up-regulation of Ran protein signal transduction" EXACT [] synonym: "upregulation of Ran protein signal transduction" EXACT [] is_a: GO:0032015 ! regulation of Ran protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction relationship: positively_regulates GO:0031291 ! Ran protein signal transduction [Term] id: GO:0032018 name: 2-methylbutanol:NADP oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+." [GOC:mah, PMID:12210903] synonym: "2-methylbutanal reductase (NADP) activity" EXACT [] synonym: "2-methylbutyraldehyde reductase (NADP) activity" EXACT [] is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] id: GO:0032019 name: mitochondrial cloud namespace: cellular_component def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166] synonym: "Balbiani body" EXACT [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032020 name: ISG15-protein conjugation namespace: biological_process def: "The covalent addition to a protein of ISG15, a ubiquitin-like protein." [GOC:mah] is_a: GO:0006464 ! protein modification process [Term] id: GO:0032021 name: NELF complex namespace: cellular_component def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062] synonym: "negative elongation factor complex" EXACT [] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0032022 name: multicellular pellicle formation namespace: biological_process def: "A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface." [GOC:ml] is_a: GO:0042710 ! biofilm formation [Term] id: GO:0032023 name: trypsinogen activation namespace: biological_process def: "The proteolytic processing of trypsinogen to the active form, trypsin." [GOC:mah] synonym: "cleavage of trypsinogen to trypsin" EXACT [] is_a: GO:0031638 ! zymogen activation [Term] id: GO:0032024 name: positive regulation of insulin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah] synonym: "activation of insulin secretion" NARROW [] synonym: "stimulation of insulin secretion" NARROW [] synonym: "up regulation of insulin secretion" EXACT [] synonym: "up-regulation of insulin secretion" EXACT [] synonym: "upregulation of insulin secretion" EXACT [] is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion relationship: positively_regulates GO:0030073 ! insulin secretion [Term] id: GO:0032025 name: response to cobalt ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0032026 name: response to magnesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0032027 name: myosin light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin complex." [GOC:mah] is_a: GO:0017022 ! myosin binding [Term] id: GO:0032028 name: myosin head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin heavy chain." [GOC:mah] is_a: GO:0032036 ! myosin heavy chain binding [Term] id: GO:0032029 name: myosin tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin heavy chain." [GOC:mah] is_a: GO:0032036 ! myosin heavy chain binding [Term] id: GO:0032030 name: myosin I light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin I complex." [GOC:mah] is_a: GO:0017024 ! myosin I binding is_a: GO:0032027 ! myosin light chain binding [Term] id: GO:0032031 name: myosin I head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin I heavy chain." [GOC:mah] is_a: GO:0032028 ! myosin head/neck binding is_a: GO:0032037 ! myosin I heavy chain binding [Term] id: GO:0032032 name: myosin I tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin I heavy chain." [GOC:mah] is_a: GO:0032029 ! myosin tail binding is_a: GO:0032037 ! myosin I heavy chain binding [Term] id: GO:0032033 name: myosin II light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah] is_a: GO:0032027 ! myosin light chain binding is_a: GO:0045159 ! myosin II binding [Term] id: GO:0032034 name: myosin II head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin II heavy chain." [GOC:mah] is_a: GO:0032028 ! myosin head/neck binding is_a: GO:0032038 ! myosin II heavy chain binding [Term] id: GO:0032035 name: myosin II tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin II heavy chain." [GOC:mah] is_a: GO:0032029 ! myosin tail binding is_a: GO:0032038 ! myosin II heavy chain binding [Term] id: GO:0032036 name: myosin heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin complex." [GOC:mah] is_a: GO:0017022 ! myosin binding [Term] id: GO:0032037 name: myosin I heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin I complex." [GOC:mah] is_a: GO:0017024 ! myosin I binding is_a: GO:0032036 ! myosin heavy chain binding [Term] id: GO:0032038 name: myosin II heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin II complex." [GOC:mah] is_a: GO:0032036 ! myosin heavy chain binding is_a: GO:0045159 ! myosin II binding [Term] id: GO:0032039 name: integrator complex namespace: cellular_component def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0032040 name: small-subunit processome namespace: cellular_component def: "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] synonym: "small subunit processome" EXACT [] synonym: "SSU processome" EXACT [] is_a: GO:0030684 ! preribosome [Term] id: GO:0032041 name: NAD-dependent histone deacetylase activity (H3-K14 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, EC:3.5.1.98, RHEA:24551] xref: EC:3.5.1.98 is_a: GO:0017136 ! NAD-dependent histone deacetylase activity is_a: GO:0031078 ! histone deacetylase activity (H3-K14 specific) [Term] id: GO:0032042 name: mitochondrial DNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA metabolism" EXACT [] synonym: "mtDNA metabolic process" EXACT [] synonym: "mtDNA metabolism" EXACT [] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0000002 ! mitochondrial genome maintenance [Term] id: GO:0032043 name: mitochondrial DNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA breakdown" EXACT [] synonym: "mitochondrial DNA catabolism" EXACT [] synonym: "mitochondrial DNA degradation" EXACT [] synonym: "mtDNA breakdown" EXACT [] synonym: "mtDNA catabolic process" EXACT [] synonym: "mtDNA catabolism" EXACT [] synonym: "mtDNA degradation" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0032042 ! mitochondrial DNA metabolic process [Term] id: GO:0032044 name: DSIF complex namespace: cellular_component def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865] synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT [] synonym: "DRB sensitivity inducing factor complex" EXACT [] synonym: "Spt4-Spt5 complex" EXACT [] synonym: "Spt5-Spt4 complex" EXACT [GOC:vw] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0032045 name: guanyl-nucleotide exchange factor complex namespace: cellular_component def: "A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032046 name: micropexophagy-specific membrane apparatus namespace: cellular_component def: "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611] synonym: "micropexophagic apparatus" EXACT [] synonym: "MIPA" EXACT [] is_a: GO:0031984 ! organelle subcompartment is_a: GO:0044437 ! vacuolar part [Term] id: GO:0032047 name: mitosome namespace: cellular_component def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria." [PMID:10361303, PMID:14614504] synonym: "crypton" EXACT [] xref: Wikipedia:Mitosome is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032048 name: cardiolipin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [CHEBI:28494, GOC:mah] synonym: "cardiolipin metabolism" EXACT [] synonym: "diphosphatidylglycerol metabolic process" RELATED [] synonym: "diphosphatidylglycerol metabolism" RELATED [] is_a: GO:0046471 ! phosphatidylglycerol metabolic process [Term] id: GO:0032049 name: cardiolipin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [CHEBI:28494, GOC:mah] synonym: "diphosphatidylglycerol biosynthesis" RELATED [] synonym: "diphosphatidylglycerol biosynthetic process" RELATED [] xref: MetaCyc:PWY-5269 is_a: GO:0006655 ! phosphatidylglycerol biosynthetic process is_a: GO:0032048 ! cardiolipin metabolic process [Term] id: GO:0032050 name: clathrin heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a clathrin heavy chain." [GOC:mah] is_a: GO:0030276 ! clathrin binding [Term] id: GO:0032051 name: clathrin light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a clathrin light chain." [GOC:mah] is_a: GO:0030276 ! clathrin binding [Term] id: GO:0032052 name: bile acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:rph] is_a: GO:0005496 ! steroid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0032053 name: microtubule basal body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum." [GOC:dph, GOC:jl, GOC:mah, PMID:9889124] synonym: "microtubule basal body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031023 ! microtubule organizing center organization [Term] id: GO:0032054 name: microtubule basal body duplication namespace: biological_process def: "Construction of a new microtubule basal body." [PMID:9889124] is_a: GO:0032053 ! microtubule basal body organization [Term] id: GO:0032055 name: negative regulation of translation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation in response to stress" EXACT [] synonym: "down-regulation of translation in response to stress" EXACT [] synonym: "downregulation of translation in response to stress" EXACT [] synonym: "inhibition of translation in response to stress" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0032056 name: positive regulation of translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation in response to stress" NARROW [] synonym: "stimulation of translation in response to stress" NARROW [] synonym: "up regulation of translation in response to stress" EXACT [] synonym: "up-regulation of translation in response to stress" EXACT [] synonym: "upregulation of translation in response to stress" EXACT [] is_a: GO:0043555 ! regulation of translation in response to stress is_a: GO:0045727 ! positive regulation of translation [Term] id: GO:0032057 name: negative regulation of translational initiation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation initiation in response to stress" EXACT [] synonym: "down-regulation of translation initiation in response to stress" EXACT [] synonym: "downregulation of translation initiation in response to stress" EXACT [] synonym: "inhibition of translation initiation in response to stress" NARROW [] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0043558 ! regulation of translational initiation in response to stress is_a: GO:0045947 ! negative regulation of translational initiation [Term] id: GO:0032058 name: positive regulation of translational initiation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation initiation in response to stress" NARROW [] synonym: "stimulation of translation initiation in response to stress" NARROW [] synonym: "up regulation of translation initiation in response to stress" EXACT [] synonym: "up-regulation of translation initiation in response to stress" EXACT [] synonym: "upregulation of translation initiation in response to stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0043558 ! regulation of translational initiation in response to stress is_a: GO:0045948 ! positive regulation of translational initiation [Term] id: GO:0032059 name: bleb namespace: cellular_component def: "A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions." [PMID:12083798, PMID:16624291] subset: goslim_pir xref: Wikipedia:Bleb_(cell_biology) is_a: GO:0042995 ! cell projection [Term] id: GO:0032060 name: bleb assembly namespace: biological_process def: "The assembly of a bleb, a cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions." [PMID:12083798, PMID:16624291] synonym: "bleb assembly" RELATED [GOC:mah] synonym: "cell blebbing" EXACT [] is_a: GO:0030031 ! cell projection assembly [Term] id: GO:0032061 name: negative regulation of translation in response to osmotic stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "down regulation of translation in response to osmotic stress" EXACT [] synonym: "down-regulation of translation in response to osmotic stress" EXACT [] synonym: "downregulation of translation in response to osmotic stress" EXACT [] synonym: "inhibition of translation in response to osmotic stress" NARROW [] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0043557 ! regulation of translation in response to osmotic stress [Term] id: GO:0032062 name: positive regulation of translation in response to osmotic stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "activation of translation in response to osmotic stress" NARROW [] synonym: "stimulation of translation in response to osmotic stress" NARROW [] synonym: "up regulation of translation in response to osmotic stress" EXACT [] synonym: "up-regulation of translation in response to osmotic stress" EXACT [] synonym: "upregulation of translation in response to osmotic stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0043557 ! regulation of translation in response to osmotic stress [Term] id: GO:0032063 name: negative regulation of translational initiation in response to osmotic stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "down regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "down-regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "downregulation of translation initiation in response to osmotic stress" EXACT [] synonym: "inhibition of translation initiation in response to osmotic stress" NARROW [] is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:0032061 ! negative regulation of translation in response to osmotic stress is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress [Term] id: GO:0032064 name: positive regulation of translational initiation in response to osmotic stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "activation of translation initiation in response to osmotic stress" NARROW [] synonym: "stimulation of translation initiation in response to osmotic stress" NARROW [] synonym: "up regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "up-regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "upregulation of translation initiation in response to osmotic stress" EXACT [] is_a: GO:0032058 ! positive regulation of translational initiation in response to stress is_a: GO:0032062 ! positive regulation of translation in response to osmotic stress is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress [Term] id: GO:0032065 name: cortical protein anchoring namespace: biological_process def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] synonym: "maintenance of protein location in cell cortex" EXACT [GOC:dph, GOC:tb] is_a: GO:0032507 ! maintenance of protein location in cell [Term] id: GO:0032066 name: nucleolus to nucleoplasm transport namespace: biological_process def: "The directed movement of substances from the nucleolus to the nucleoplasm." [GOC:mah] is_a: GO:0051169 ! nuclear transport [Term] id: GO:0032067 name: Type IV site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)." [PMID:12654995] synonym: "Type IV restriction enzyme activity" EXACT [] is_a: GO:0015666 ! restriction endodeoxyribonuclease activity [Term] id: GO:0032068 name: Type IV site-specific deoxyribonuclease complex namespace: cellular_component def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995] synonym: "Type IV restriction enzyme complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032069 name: regulation of nuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] synonym: "nuclease regulator activity" RELATED [] is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0032070 name: regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] synonym: "deoxyribonuclease regulator" RELATED [] synonym: "DNase regulator" RELATED [] is_a: GO:0032069 ! regulation of nuclease activity [Term] id: GO:0032071 name: regulation of endodeoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] synonym: "endodeoxyribonuclease regulator" RELATED [] is_a: GO:0032070 ! regulation of deoxyribonuclease activity [Term] id: GO:0032072 name: regulation of restriction endodeoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity [Term] id: GO:0032073 name: negative regulation of restriction endodeoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] synonym: "down regulation of restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of restriction endodeoxyribonuclease activity" NARROW [] synonym: "restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "restriction enzyme inhibitor" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity is_a: GO:0032078 ! negative regulation of endodeoxyribonuclease activity [Term] id: GO:0032074 name: negative regulation of nuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] synonym: "down regulation of nuclease activity" EXACT [] synonym: "down-regulation of nuclease activity" EXACT [] synonym: "downregulation of nuclease activity" EXACT [] synonym: "inhibition of nuclease activity" NARROW [] synonym: "nuclease inhibitor" RELATED [] is_a: GO:0032069 ! regulation of nuclease activity is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0032075 name: positive regulation of nuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] synonym: "activation of nuclease activity" NARROW [] synonym: "nuclease activator" RELATED [] synonym: "stimulation of nuclease activity" NARROW [] synonym: "up regulation of nuclease activity" EXACT [] synonym: "up-regulation of nuclease activity" EXACT [] synonym: "upregulation of nuclease activity" EXACT [] is_a: GO:0032069 ! regulation of nuclease activity is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0032076 name: negative regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] synonym: "deoxyribonuclease inhibitor" RELATED [] synonym: "DNase inhibitor" RELATED [] synonym: "down regulation of deoxyribonuclease activity" EXACT [] synonym: "down-regulation of deoxyribonuclease activity" EXACT [] synonym: "downregulation of deoxyribonuclease activity" EXACT [] synonym: "inhibition of deoxyribonuclease activity" NARROW [] is_a: GO:0032070 ! regulation of deoxyribonuclease activity is_a: GO:0032074 ! negative regulation of nuclease activity [Term] id: GO:0032077 name: positive regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] synonym: "activation of deoxyribonuclease activity" NARROW [] synonym: "deoxyribonuclease activator" RELATED [] synonym: "DNase activator" RELATED [] synonym: "stimulation of deoxyribonuclease activity" NARROW [] synonym: "up regulation of deoxyribonuclease activity" EXACT [] synonym: "up-regulation of deoxyribonuclease activity" EXACT [] synonym: "upregulation of deoxyribonuclease activity" EXACT [] is_a: GO:0032070 ! regulation of deoxyribonuclease activity is_a: GO:0032075 ! positive regulation of nuclease activity [Term] id: GO:0032078 name: negative regulation of endodeoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] synonym: "down regulation of endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of endodeoxyribonuclease activity" EXACT [] synonym: "endodeoxyribonuclease inhibitor" RELATED [] synonym: "inhibition of endodeoxyribonuclease activity" NARROW [] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity [Term] id: GO:0032079 name: positive regulation of endodeoxyribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] synonym: "activation of endodeoxyribonuclease activity" NARROW [] synonym: "endodeoxyribonuclease activator" RELATED [] synonym: "stimulation of endodeoxyribonuclease activity" NARROW [] synonym: "up regulation of endodeoxyribonuclease activity" EXACT [] synonym: "up-regulation of endodeoxyribonuclease activity" EXACT [] synonym: "upregulation of endodeoxyribonuclease activity" EXACT [] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity [Term] id: GO:0032080 name: negative regulation of Type I site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of Type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of Type I restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of Type I restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of Type I restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of Type I restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of Type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "Type I restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "Type I restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032084 ! regulation of Type I site-specific deoxyribonuclease activity [Term] id: GO:0032081 name: negative regulation of Type II site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of Type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of Type II restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of Type II restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of Type II restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of Type II restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of Type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "Type II restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "Type II restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032085 ! regulation of Type II site-specific deoxyribonuclease activity [Term] id: GO:0032082 name: negative regulation of Type III site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of Type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of Type III restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of Type III restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of Type III restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of Type III restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of Type III restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "Type III restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "Type III restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032086 ! regulation of Type III site-specific deoxyribonuclease activity [Term] id: GO:0032083 name: negative regulation of Type IV site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of Type IV restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of Type IV restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of Type IV restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "Type IV restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "Type IV restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032087 ! regulation of Type IV site-specific deoxyribonuclease activity [Term] id: GO:0032084 name: regulation of Type I site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a Type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] synonym: "regulation of Type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph] synonym: "Type I restriction endodeoxyribonuclease regulator" RELATED [] synonym: "Type I restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity [Term] id: GO:0032085 name: regulation of Type II site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a Type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] synonym: "regulation of Type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph] synonym: "Type II restriction endodeoxyribonuclease regulator" RELATED [] synonym: "Type II restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity [Term] id: GO:0032086 name: regulation of Type III site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a Type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] synonym: "regulation of Type III restriction endoribonuclease activity" EXACT [GOC:dph] synonym: "Type III restriction endodeoxyribonuclease regulator" RELATED [] synonym: "Type III restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity [Term] id: GO:0032087 name: regulation of Type IV site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a Type IV restriction endodeoxyribonuclease activity." [GOC:mah] synonym: "regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph] synonym: "Type IV restriction endodeoxyribonuclease regulator" RELATED [] synonym: "Type IV restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity [Term] id: GO:0032088 name: negative regulation of NF-kappaB transcription factor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "NF-kappaB inhibitor" RELATED [] is_a: GO:0043433 ! negative regulation of sequence-specific DNA binding transcription factor activity [Term] id: GO:0032089 name: NACHT domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs." [GOC:rl] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032090 name: Pyrin domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl] synonym: "DAPIN domain binding" EXACT [] synonym: "PAAD domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032091 name: negative regulation of protein binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah] subset: gosubset_prok synonym: "down regulation of protein binding" EXACT [] synonym: "down-regulation of protein binding" EXACT [] synonym: "downregulation of protein binding" EXACT [] synonym: "inhibition of protein binding" NARROW [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051100 ! negative regulation of binding [Term] id: GO:0032092 name: positive regulation of protein binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah] subset: gosubset_prok synonym: "activation of protein binding" NARROW [] synonym: "stimulation of protein binding" NARROW [] synonym: "up regulation of protein binding" EXACT [] synonym: "up-regulation of protein binding" EXACT [] synonym: "upregulation of protein binding" EXACT [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051099 ! positive regulation of binding [Term] id: GO:0032093 name: SAM domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230] synonym: "Sterile Alpha Motif domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032094 name: response to food namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:add, ISBN:0721601464] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0032095 name: regulation of response to food namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] is_a: GO:0032107 ! regulation of response to nutrient levels relationship: regulates GO:0032094 ! response to food [Term] id: GO:0032096 name: negative regulation of response to food namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus." [GOC:add] synonym: "down regulation of response to food" EXACT [] synonym: "down-regulation of response to food" EXACT [] synonym: "downregulation of response to food" EXACT [] synonym: "inhibition of response to food" NARROW [] is_a: GO:0032095 ! regulation of response to food is_a: GO:0032108 ! negative regulation of response to nutrient levels relationship: negatively_regulates GO:0032094 ! response to food [Term] id: GO:0032097 name: positive regulation of response to food namespace: biological_process def: "Any process that activates, maintains, or increases the rate of a response to a food stimulus." [GOC:add] synonym: "activation of response to food" NARROW [] synonym: "stimulation of response to food" NARROW [] synonym: "up regulation of response to food" EXACT [] synonym: "up-regulation of response to food" EXACT [] synonym: "upregulation of response to food" EXACT [] is_a: GO:0032095 ! regulation of response to food is_a: GO:0032109 ! positive regulation of response to nutrient levels relationship: positively_regulates GO:0032094 ! response to food [Term] id: GO:0032098 name: regulation of appetite namespace: biological_process def: "Any process which modulates appetite, the desire or physical craving for food." [GOC:add] synonym: "regulation of hunger" RELATED [] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0031667 ! response to nutrient levels [Term] id: GO:0032099 name: negative regulation of appetite namespace: biological_process def: "Any process that reduces appetite." [GOC:add] synonym: "appetite suppression" RELATED [] synonym: "down regulation of appetite" EXACT [] synonym: "down-regulation of appetite" EXACT [] synonym: "downregulation of appetite" EXACT [] synonym: "inhibition of appetite" NARROW [] synonym: "negative regulation of hunger" RELATED [] is_a: GO:0032096 ! negative regulation of response to food is_a: GO:0032098 ! regulation of appetite [Term] id: GO:0032100 name: positive regulation of appetite namespace: biological_process def: "Any process that increases appetite." [GOC:add] synonym: "activation of appetite" NARROW [] synonym: "appetite stimulation" RELATED [] synonym: "positive regulation of hunger" RELATED [] synonym: "stimulation of appetite" NARROW [] synonym: "up regulation of appetite" EXACT [] synonym: "up-regulation of appetite" EXACT [] synonym: "upregulation of appetite" EXACT [] is_a: GO:0032097 ! positive regulation of response to food is_a: GO:0032098 ! regulation of appetite [Term] id: GO:0032101 name: regulation of response to external stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] synonym: "down regulation of response to external stimulus" EXACT [] synonym: "down-regulation of response to external stimulus" EXACT [] synonym: "downregulation of response to external stimulus" EXACT [] synonym: "inhibition of response to external stimulus" NARROW [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] synonym: "activation of response to external stimulus" NARROW [] synonym: "stimulation of response to external stimulus" NARROW [] synonym: "up regulation of response to external stimulus" EXACT [] synonym: "up-regulation of response to external stimulus" EXACT [] synonym: "upregulation of response to external stimulus" EXACT [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032104 name: regulation of response to extracellular stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] is_a: GO:0032101 ! regulation of response to external stimulus relationship: regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032105 name: negative regulation of response to extracellular stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] synonym: "down regulation of response to extracellular stimulus" EXACT [] synonym: "down-regulation of response to extracellular stimulus" EXACT [] synonym: "downregulation of response to extracellular stimulus" EXACT [] synonym: "inhibition of response to extracellular stimulus" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0032104 ! regulation of response to extracellular stimulus relationship: negatively_regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032106 name: positive regulation of response to extracellular stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." [GOC:mah] synonym: "activation of response to extracellular stimulus" NARROW [] synonym: "stimulation of response to extracellular stimulus" NARROW [] synonym: "up regulation of response to extracellular stimulus" EXACT [] synonym: "up-regulation of response to extracellular stimulus" EXACT [] synonym: "upregulation of response to extracellular stimulus" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0032104 ! regulation of response to extracellular stimulus relationship: positively_regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032107 name: regulation of response to nutrient levels namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to nutrient levels." [GOC:mah] is_a: GO:0032104 ! regulation of response to extracellular stimulus relationship: regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032108 name: negative regulation of response to nutrient levels namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels." [GOC:mah] synonym: "down regulation of response to nutrient levels" EXACT [] synonym: "down-regulation of response to nutrient levels" EXACT [] synonym: "downregulation of response to nutrient levels" EXACT [] synonym: "inhibition of response to nutrient levels" NARROW [] is_a: GO:0032105 ! negative regulation of response to extracellular stimulus is_a: GO:0032107 ! regulation of response to nutrient levels relationship: negatively_regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032109 name: positive regulation of response to nutrient levels namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." [GOC:mah] synonym: "activation of response to nutrient levels" NARROW [] synonym: "stimulation of response to nutrient levels" NARROW [] synonym: "up regulation of response to nutrient levels" EXACT [] synonym: "up-regulation of response to nutrient levels" EXACT [] synonym: "upregulation of response to nutrient levels" EXACT [] is_a: GO:0032106 ! positive regulation of response to extracellular stimulus is_a: GO:0032107 ! regulation of response to nutrient levels relationship: positively_regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032110 name: regulation of protein histidine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] is_a: GO:0045859 ! regulation of protein kinase activity [Term] id: GO:0032111 name: activation of protein histidine kinase activity namespace: biological_process def: "Any process that initiates the activity of an inactive protein histidine kinase." [GOC:mah] synonym: "protein histidine kinase activator" RELATED [] is_a: GO:0010864 ! positive regulation of protein histidine kinase activity is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0032112 name: negative regulation of protein histidine kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] synonym: "down regulation of protein histidine kinase activity" EXACT [] synonym: "down-regulation of protein histidine kinase activity" EXACT [] synonym: "downregulation of protein histidine kinase activity" EXACT [] synonym: "inhibition of protein histidine kinase activity" NARROW [] synonym: "protein histidine kinase inhibitor" RELATED [] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0032110 ! regulation of protein histidine kinase activity [Term] id: GO:0032113 name: regulation of carbohydrate phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate." [GOC:mah] is_a: GO:0010921 ! regulation of phosphatase activity [Term] id: GO:0032114 name: regulation of glucose-6-phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [GOC:kp] is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity [Term] id: GO:0032115 name: sorbose reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction." [EC:1.1.1.289, RHEA:14612] synonym: "D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.289] synonym: "Sou1p" RELATED [EC:1.1.1.289] xref: EC:1.1.1.289 xref: KEGG:R07346 xref: MetaCyc:1.1.1.289-RXN xref: RHEA:14612 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0032116 name: SMC loading complex namespace: cellular_component def: "A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved." [GOC:curators, GOC:vw, PMID:10882066] synonym: "chromatin loading complex" RELATED [GOC:curators] synonym: "cohesin loading complex" NARROW [GOC:curators] synonym: "SCC2/SCC4 loading complex" NARROW [GOC:curators] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032117 name: horsetail-astral microtubule array namespace: cellular_component def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942] synonym: "HAA" EXACT [] is_a: GO:0005818 ! aster [Term] id: GO:0032118 name: horsetail-astral microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis." [GOC:mah] synonym: "horsetail-astral microtubule array organization" EXACT [] synonym: "horsetail-astral microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0032119 name: sequestering of zinc ion namespace: biological_process def: "The process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:mah] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0006882 ! cellular zinc ion homeostasis [Term] id: GO:0032120 name: ascospore-type prospore membrane assembly namespace: biological_process def: "The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GOC:clt] synonym: "forespore membrane biosynthesis" EXACT [] synonym: "forespore membrane formation" EXACT [] synonym: "FSM assembly" EXACT [] synonym: "FSM biosynthesis" EXACT [] synonym: "FSM formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0071709 ! membrane assembly relationship: part_of GO:0031321 ! ascospore-type prospore formation [Term] id: GO:0032121 name: attachment of telomeres to spindle pole body namespace: biological_process def: "The cell cycle process in which physical connections are formed between telomeres and the spindle pole body, facilitating bouquet formation." [PMID:16615890] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0045141 ! meiotic telomere clustering [Term] id: GO:0032122 name: oral apparatus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans." [PMID:10503189, PMID:6414830] synonym: "oral apparatus morphogenesis" RELATED [] synonym: "oral apparatus organization and biogenesis" RELATED [GOC:mah] synonym: "stomatogenesis" RELATED [] is_a: GO:0030030 ! cell projection organization [Term] id: GO:0032123 name: deep fiber namespace: cellular_component def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189] synonym: "deep fibre" EXACT [] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0031912 ! oral apparatus [Term] id: GO:0032124 name: macronucleus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] synonym: "macronuclear organization" EXACT [] synonym: "macronuclear organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0032125 name: micronucleus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] synonym: "micronuclear organization" EXACT [] synonym: "micronuclear organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0032126 name: eisosome namespace: cellular_component def: "Any of the large immobile protein assemblies at the plasma membrane that mark endocytic sites. In yeast, S. cerevisiae, these structures are primarily composed of Pil1p and Lsp1p." [PMID:16496001] xref: Wikipedia:Eisosome is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part [Term] id: GO:0032127 name: dense core granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] synonym: "dense core vesicle membrane" EXACT [GOC:kmv] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0031045 ! dense core granule [Term] id: GO:0032128 name: flocculation via extracellular polymer namespace: biological_process def: "Non-sexual aggregation of single-celled organisms mediated by polymers (polysaccharides, proteins, and/or nucleic acids) secreted into the extracellular environment." [DOI:10.1007/s002530051351, GOC:mah, PMID:14538073] subset: gosubset_prok synonym: "flocculation via EBF" EXACT [] synonym: "flocculation via extracellular biopolymeric flocculants" EXACT [] is_a: GO:0000128 ! flocculation [Term] id: GO:0032129 name: histone deacetylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, EC:3.5.1.98, RHEA:24551] xref: EC:3.5.1.98 is_a: GO:0004407 ! histone deacetylase activity [Term] id: GO:0032130 name: medial membrane band assembly namespace: biological_process def: "The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring." [PMID:15517003] synonym: "medial membrane band formation" RELATED [gOC:dph] is_a: GO:0032506 ! cytokinetic process is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0032131 name: alkylated DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with alkylated residues in DNA." [GOC:mah] is_a: GO:0003684 ! damaged DNA binding [Term] id: GO:0032132 name: O6-alkylguanine-DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with O6-alkylguanine adducts in DNA." [GOC:mah, PMID:16679453] is_a: GO:0032131 ! alkylated DNA binding [Term] id: GO:0032133 name: chromosome passenger complex namespace: cellular_component def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910] synonym: "chromosomal passenger complex" EXACT [GOC:mcc] synonym: "CPC" BROAD [GOC:mah] synonym: "CPC complex" EXACT [GOC:vw] is_a: GO:0005875 ! microtubule associated complex [Term] id: GO:0032135 name: DNA insertion or deletion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing insertions or deletions." [GOC:vk] synonym: "DNA insertion binding" NARROW [] synonym: "insertion binding" EXACT [] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0032136 name: adenine/cytosine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/C mispair." [GOC:vk] synonym: "A/C mispair binding" EXACT [GOC:bf] synonym: "C/A mispair binding" EXACT [GOC:bf] synonym: "cytosine/adenine mispair binding" RELATED [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0032137 name: guanine/thymine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair." [GOC:vk] synonym: "G/T mispair binding" EXACT [GOC:bf] synonym: "T/G mispair binding" EXACT [GOC:bf] synonym: "thymine/guanine mispair binding" EXACT [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0032138 name: single base insertion or deletion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion." [GOC:vk] synonym: "single base insertion binding" NARROW [] is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0032139 name: dinucleotide insertion or deletion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion." [GOC:vk] synonym: "dinucleotide insertion binding" NARROW [] is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0032140 name: single adenine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single adenine insertion or a deletion that results in an unpaired adenine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032141 name: single cytosine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single cytosine insertion or a deletion that results in an unpaired cytosine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032142 name: single guanine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032143 name: single thymine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032144 name: 4-aminobutyrate transaminase complex namespace: cellular_component def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998] synonym: "ABAT complex" EXACT [] synonym: "GABA transaminase complex" EXACT [] synonym: "GABA-T complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032145 name: succinate-semialdehyde dehydrogenase binding namespace: molecular_function def: "Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase." [GOC:mah] synonym: "succinic semialdehyde dehydrogenase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0032146 name: thiosulfate transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)." [GOC:mlg] is_a: GO:0015117 ! thiosulfate transmembrane transporter activity is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity [Term] id: GO:0032147 name: activation of protein kinase activity namespace: biological_process def: "Any process that initiates the activity of an inactive protein kinase." [GOC:mah] synonym: "protein kinase activation" RELATED [] is_a: GO:0045860 ! positive regulation of protein kinase activity [Term] id: GO:0032148 name: activation of protein kinase B activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme protein kinase B." [GOC:pg] synonym: "protein kinase B activation" EXACT [] is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0032149 name: response to rhamnose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mlg] synonym: "response to L-rhamnose stimulus" NARROW [] is_a: GO:0009746 ! response to hexose stimulus [Term] id: GO:0032150 name: ubiquinone biosynthetic process from chorismate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032151 name: mitotic septin complex namespace: cellular_component def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555] is_a: GO:0031105 ! septin complex [Term] id: GO:0032152 name: meiotic septin complex namespace: cellular_component def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555] is_a: GO:0031105 ! septin complex [Term] id: GO:0032153 name: cell division site namespace: cellular_component def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. The cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane. The mitotic, or meiotic, spindle is aligned perpendicular to the division plane." [GOC:krc, GOC:ns, PMID:12101122, PMID:15380095] comment: Note that this term refers to the future site of division in a cell that has not yet divided. subset: goslim_pir synonym: "cell division plane" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0032154 name: cleavage furrow namespace: cellular_component def: "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] xref: Wikipedia:Cleavage_furrow is_a: GO:0032155 ! cell division site part [Term] id: GO:0032155 name: cell division site part namespace: cellular_component def: "Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah] synonym: "cell division plane part" EXACT [] is_a: GO:0044464 ! cell part relationship: part_of GO:0032153 ! cell division site [Term] id: GO:0032156 name: septin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0032157 name: prospore contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555] synonym: "actomyosin ring" BROAD [] synonym: "cytokinetic ring" BROAD [] synonym: "meiotic contractile ring" RELATED [] is_a: GO:0005826 ! actomyosin contractile ring relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0032158 name: septin band namespace: cellular_component def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0032156 ! septin cytoskeleton [Term] id: GO:0032159 name: septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part [Term] id: GO:0032160 name: septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244] synonym: "septin bar" RELATED [] is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part [Term] id: GO:0032161 name: cleavage apparatus septin structure namespace: cellular_component def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555] is_a: GO:0032155 ! cell division site part is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0032156 ! septin cytoskeleton [Term] id: GO:0032162 name: mating projection septin band namespace: cellular_component def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0032158 ! septin band is_a: GO:0044463 ! cell projection part relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0032163 name: hyphal septin band namespace: cellular_component def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0032158 ! septin band [Term] id: GO:0032164 name: hyphal septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] is_a: GO:0032159 ! septin cap [Term] id: GO:0032165 name: prospore septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244] is_a: GO:0032160 ! septin filament array [Term] id: GO:0032166 name: chlamydospore septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244] is_a: GO:0032160 ! septin filament array [Term] id: GO:0032167 name: septin patch namespace: cellular_component def: "OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis." [PMID:16009555] comment: This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure. is_obsolete: true [Term] id: GO:0032168 name: hyphal septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring [Term] id: GO:0032169 name: prospore septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0032170 name: pseudohyphal septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring [Term] id: GO:0032171 name: germ tube septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] is_a: GO:0032159 ! septin cap relationship: part_of GO:0032179 ! germ tube [Term] id: GO:0032172 name: germ tube septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244] is_a: GO:0005940 ! septin ring relationship: part_of GO:0032179 ! germ tube [Term] id: GO:0032173 name: septin collar namespace: cellular_component def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244] is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part [Term] id: GO:0032174 name: cellular bud neck septin collar namespace: cellular_component def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0032161 ! cleavage apparatus septin structure is_a: GO:0032173 ! septin collar [Term] id: GO:0032175 name: mating projection septin ring namespace: cellular_component def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring is_a: GO:0044463 ! cell projection part relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0032176 name: split septin rings namespace: cellular_component def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244] is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part [Term] id: GO:0032177 name: cellular bud neck split septin rings namespace: cellular_component def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0032161 ! cleavage apparatus septin structure is_a: GO:0032176 ! split septin rings [Term] id: GO:0032178 name: medial membrane band namespace: cellular_component def: "A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003] synonym: "sterol-rich membrane band" RELATED [] is_a: GO:0032155 ! cell division site part is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0032179 name: germ tube namespace: cellular_component def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148] subset: goslim_pir xref: Wikipedia:Germ_tube is_a: GO:0044464 ! cell part [Term] id: GO:0032180 name: ubiquinone biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032181 name: dinucleotide repeat insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats." [GOC:mah, GOC:vk] is_a: GO:0032139 ! dinucleotide insertion or deletion binding [Term] id: GO:0032182 name: small conjugating protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0032183 name: SUMO binding namespace: molecular_function def: "Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO." [GOC:mah] synonym: "Smt3 binding" RELATED [] synonym: "Smt3 monomer binding" NARROW [] is_a: GO:0032182 ! small conjugating protein binding [Term] id: GO:0032184 name: SUMO polymer binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO." [GOC:mah] synonym: "Smt3 polymer binding" EXACT [] is_a: GO:0032183 ! SUMO binding [Term] id: GO:0032185 name: septin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: gosubset_prok synonym: "septin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization [Term] id: GO:0032186 name: cellular bud neck septin ring organization namespace: biological_process def: "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck." [GOC:mah] is_a: GO:0031106 ! septin ring organization is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0010687 ! site selection involved in cell cycle cytokinesis [Term] id: GO:0032187 name: contractile ring localization involved in cell cycle cytokinesis namespace: biological_process def: "The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah] synonym: "contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] is_a: GO:0032506 ! cytokinetic process is_a: GO:0051641 ! cellular localization relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0032188 name: establishment of contractile ring localization involved in cell cycle cytokinesis namespace: biological_process def: "The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis." [GOC:mah] synonym: "actomyosin ring positioning" RELATED [GOC:mah] synonym: "contractile ring positioning" BROAD [GOC:mah] synonym: "cytokinesis site selection by contractile ring positioning" EXACT [GOC:mah, GOC:vw] synonym: "establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032187 ! contractile ring localization involved in cell cycle cytokinesis relationship: part_of GO:0010687 ! site selection involved in cell cycle cytokinesis [Term] id: GO:0032189 name: maintenance of contractile ring localization involved in cell cycle cytokinesis namespace: biological_process def: "Any process in which a contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah] synonym: "cytokinetic ring anchoring" RELATED [] synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032187 ! contractile ring localization involved in cell cycle cytokinesis relationship: part_of GO:0031566 ! contractile ring maintenance involved in cell cycle cytokinesis [Term] id: GO:0032190 name: acrosin binding namespace: molecular_function def: "Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities." [GOC:mah, PMID:12398221] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0032191 name: acrosin heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the larger of the two covalently linked polypeptide chains of acrosin." [GOC:mah, PMID:12398221] is_a: GO:0032190 ! acrosin binding [Term] id: GO:0032192 name: acrosin light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the smaller of the two covalently linked polypeptide chains of acrosin." [GOC:mah, PMID:12398221] is_a: GO:0032190 ! acrosin binding [Term] id: GO:0032193 name: ubiquinone biosynthetic process via 2-polyprenylphenol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032194 name: ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032195 name: post-lysosomal vacuole namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:9276759, PMID:9394012] is_a: GO:0005773 ! vacuole is_a: GO:0030139 ! endocytic vesicle [Term] id: GO:0032196 name: transposition namespace: biological_process def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Transposon is_a: GO:0009987 ! cellular process [Term] id: GO:0032197 name: transposition, RNA-mediated namespace: biological_process alt_id: GO:0006319 alt_id: GO:0006320 alt_id: GO:0006321 alt_id: GO:0006322 def: "Any process involved in a type of transpositional recombination which occurs via an RNA intermediate." [GOC:jp, ISBN:1555812090] subset: gosubset_prok synonym: "Class I transposition" EXACT [] synonym: "retrotransposition" EXACT [] synonym: "retrotransposon transposition" EXACT [] synonym: "RNA-mediated transposition" EXACT [GOC:dph, GOC:tb] synonym: "Tf transposition" NARROW [] synonym: "Ty element transposition" NARROW [] synonym: "Ty1 element transposition" NARROW [] synonym: "Ty2 element transposition" NARROW [] synonym: "Ty3 element transposition" NARROW [] xref: Wikipedia:Transposon##Class_I\:_Retrotransposons is_a: GO:0032196 ! transposition [Term] id: GO:0032198 name: MITE transposition namespace: biological_process def: "Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs)." [GOC:jp, ISBN:1555812090] synonym: "Class III transposition" EXACT [] is_a: GO:0032196 ! transposition [Term] id: GO:0032199 name: reverse transcription involved in RNA-mediated transposition namespace: biological_process def: "The synthesis of DNA from an RNA transposon intermediate." [GOC:jp, GOC:txnOH, ISBN:1555812090] synonym: "reverse transcription during retrotransposition" EXACT [] is_a: GO:0001171 ! reverse transcription relationship: part_of GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0032200 name: telomere organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] synonym: "chromosome organization, telomeric" EXACT [] synonym: "organization of chromosome, telomeric region" EXACT [] synonym: "telomere organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0032201 name: telomere maintenance via semi-conservative replication namespace: biological_process def: "The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors." [GOC:vw, PMID:16598261] synonym: "equal telomere replication" RELATED [] synonym: "telomeric fork progression" NARROW [] synonym: "telomeric replication fork progression" NARROW [] xref: Reactome:1253407 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1280346 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1299186 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1326924 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1353016 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1373211 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1393226 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1417721 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1450821 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1471232 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1483221 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1496915 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1514304 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1521170 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1526914 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1532649 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:1536076 "Telomere C-strand (Lagging Strand) Synthesis" xref: Reactome:174417 "Telomere C-strand (Lagging Strand) Synthesis" is_a: GO:0006261 ! DNA-dependent DNA replication is_a: GO:0010833 ! telomere maintenance via telomere lengthening [Term] id: GO:0032202 name: telomere assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins." [GOC:mah, GOC:ns, PMID:11902675, PMID:8622671] synonym: "telomere formation" EXACT [] is_a: GO:0032200 ! telomere organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0032203 name: telomere formation via telomerase namespace: biological_process def: "The addition of telomeric repeats to a non-telomeric double-stranded DNA end by telomerase." [GOC:ns, PMID:11902675, PMID:8622671] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032202 ! telomere assembly [Term] id: GO:0032204 name: regulation of telomere maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051052 ! regulation of DNA metabolic process relationship: regulates GO:0000723 ! telomere maintenance [Term] id: GO:0032205 name: negative regulation of telomere maintenance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] synonym: "down regulation of telomere maintenance" EXACT [] synonym: "down-regulation of telomere maintenance" EXACT [] synonym: "downregulation of telomere maintenance" EXACT [] synonym: "inhibition of telomere maintenance" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0051053 ! negative regulation of DNA metabolic process relationship: negatively_regulates GO:0000723 ! telomere maintenance [Term] id: GO:0032206 name: positive regulation of telomere maintenance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] synonym: "activation of telomere maintenance" NARROW [] synonym: "stimulation of telomere maintenance" NARROW [] synonym: "up regulation of telomere maintenance" EXACT [] synonym: "up-regulation of telomere maintenance" EXACT [] synonym: "upregulation of telomere maintenance" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0051054 ! positive regulation of DNA metabolic process relationship: positively_regulates GO:0000723 ! telomere maintenance [Term] id: GO:0032207 name: regulation of telomere maintenance via recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] is_a: GO:0000019 ! regulation of mitotic recombination is_a: GO:0032204 ! regulation of telomere maintenance relationship: regulates GO:0000722 ! telomere maintenance via recombination [Term] id: GO:0032208 name: negative regulation of telomere maintenance via recombination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] synonym: "down regulation of telomere maintenance via recombination" EXACT [] synonym: "down-regulation of telomere maintenance via recombination" EXACT [] synonym: "downregulation of telomere maintenance via recombination" EXACT [] synonym: "inhibition of telomere maintenance via recombination" NARROW [] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:0032207 ! regulation of telomere maintenance via recombination is_a: GO:0045950 ! negative regulation of mitotic recombination relationship: negatively_regulates GO:0000722 ! telomere maintenance via recombination [Term] id: GO:0032209 name: positive regulation of telomere maintenance via recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] synonym: "activation of telomere maintenance via recombination" NARROW [] synonym: "stimulation of telomere maintenance via recombination" NARROW [] synonym: "up regulation of telomere maintenance via recombination" EXACT [] synonym: "up-regulation of telomere maintenance via recombination" EXACT [] synonym: "upregulation of telomere maintenance via recombination" EXACT [] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:0032207 ! regulation of telomere maintenance via recombination is_a: GO:0045951 ! positive regulation of mitotic recombination relationship: positively_regulates GO:0000722 ! telomere maintenance via recombination [Term] id: GO:0032210 name: regulation of telomere maintenance via telomerase namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] is_a: GO:0006275 ! regulation of DNA replication is_a: GO:0032204 ! regulation of telomere maintenance relationship: regulates GO:0007004 ! telomere maintenance via telomerase [Term] id: GO:0032211 name: negative regulation of telomere maintenance via telomerase namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] synonym: "down regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "down-regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "downregulation of telomere maintenance via telomerase activity" EXACT [] synonym: "inhibition of telomere maintenance via telomerase" NARROW [] is_a: GO:0008156 ! negative regulation of DNA replication is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:0032210 ! regulation of telomere maintenance via telomerase relationship: negatively_regulates GO:0007004 ! telomere maintenance via telomerase [Term] id: GO:0032212 name: positive regulation of telomere maintenance via telomerase namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] synonym: "activation of telomere maintenance via telomerase" NARROW [] synonym: "stimulation of telomere maintenance via telomerase" NARROW [] synonym: "up regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "up-regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "upregulation of telomere maintenance via telomerase activity" EXACT [] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:0032210 ! regulation of telomere maintenance via telomerase is_a: GO:0045740 ! positive regulation of DNA replication relationship: positively_regulates GO:0007004 ! telomere maintenance via telomerase [Term] id: GO:0032213 name: regulation of telomere maintenance via semi-conservative replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: regulates GO:0032201 ! telomere maintenance via semi-conservative replication [Term] id: GO:0032214 name: negative regulation of telomere maintenance via semi-conservative replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] synonym: "down regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "down-regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "downregulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "inhibition of telomere maintenance via semi-conservative replication" NARROW [] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication relationship: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication [Term] id: GO:0032215 name: positive regulation of telomere maintenance via semi-conservative replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] synonym: "activation of telomere maintenance via semi-conservative replication" NARROW [] synonym: "stimulation of telomere maintenance via semi-conservative replication" NARROW [] synonym: "up regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "up-regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "upregulation of telomere maintenance via semi-conservative replication" EXACT [] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication relationship: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication [Term] id: GO:0032216 name: glucosaminyl-phosphotidylinositol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucosaminyl-phosphotidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phosphotidylinositol + CoA." [Reactome:REACT_1049.1] synonym: "GPI-inositol acyltransferase" RELATED [] xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0032217 name: riboflavin transporter activity namespace: molecular_function def: "Facilitates the directed movement of riboflavin into, out of or within a cell, or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] is_a: GO:0051183 ! vitamin transporter activity [Term] id: GO:0032218 name: riboflavin transport namespace: biological_process def: "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] is_a: GO:0051180 ! vitamin transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0032219 name: cell wall macromolecule catabolic process involved in cytogamy namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy." [GOC:mah] synonym: "cell wall macromolecule catabolic process during cytogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0044039 ! cellular cell wall macromolecule catabolic process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000755 ! cytogamy [Term] id: GO:0032220 name: plasma membrane fusion involved in cytogamy namespace: biological_process def: "The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy." [GOC:mah] synonym: "plasma membrane fusion during cytogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0045026 ! plasma membrane fusion is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000755 ! cytogamy [Term] id: GO:0032221 name: Rpd3S complex namespace: cellular_component alt_id: GO:0000509 def: "A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151] synonym: "Clr6 histone deacetylase complex II'" EXACT [GOC:vw] synonym: "Clr6S complex" EXACT [PMID:19040720] synonym: "Rpd3C(S)" EXACT [] is_a: GO:0070822 ! Sin3-type complex [Term] id: GO:0032222 name: regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] is_a: GO:0050804 ! regulation of synaptic transmission relationship: regulates GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0032223 name: negative regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "down regulation of synaptic transmission, cholinergic" EXACT [] synonym: "down-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "downregulation of synaptic transmission, cholinergic" EXACT [] synonym: "inhibition of synaptic transmission, cholinergic" NARROW [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050805 ! negative regulation of synaptic transmission relationship: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0032224 name: positive regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "activation of synaptic transmission, cholinergic" NARROW [] synonym: "stimulation of synaptic transmission, cholinergic" NARROW [] synonym: "up regulation of synaptic transmission, cholinergic" EXACT [] synonym: "up-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "upregulation of synaptic transmission, cholinergic" EXACT [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050806 ! positive regulation of synaptic transmission relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0032225 name: regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] is_a: GO:0050804 ! regulation of synaptic transmission relationship: regulates GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0032226 name: positive regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] synonym: "activation of synaptic transmission, dopaminergic" NARROW [] synonym: "stimulation of synaptic transmission, dopaminergic" NARROW [] synonym: "up regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "upregulation of synaptic transmission, dopaminergic" EXACT [] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0050806 ! positive regulation of synaptic transmission relationship: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0032227 name: negative regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] synonym: "down regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "downregulation of synaptic transmission, dopaminergic" EXACT [] synonym: "inhibition of synaptic transmission, dopaminergic" NARROW [] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0050805 ! negative regulation of synaptic transmission relationship: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0032228 name: regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] is_a: GO:0050804 ! regulation of synaptic transmission relationship: regulates GO:0051932 ! synaptic transmission, GABAergic [Term] id: GO:0032229 name: negative regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "down regulation of synaptic transmission, GABAergic" EXACT [] synonym: "down-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "downregulation of synaptic transmission, GABAergic" EXACT [] synonym: "inhibition of synaptic transmission, GABAergic" NARROW [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050805 ! negative regulation of synaptic transmission relationship: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic [Term] id: GO:0032230 name: positive regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "activation of synaptic transmission, GABAergic" NARROW [] synonym: "stimulation of synaptic transmission, GABAergic" NARROW [] synonym: "up regulation of synaptic transmission, GABAergic" EXACT [] synonym: "up-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "upregulation of synaptic transmission, GABAergic" EXACT [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050806 ! positive regulation of synaptic transmission relationship: positively_regulates GO:0051932 ! synaptic transmission, GABAergic [Term] id: GO:0032231 name: regulation of actin filament bundle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb] synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:0044087 ! regulation of cellular component biogenesis relationship: regulates GO:0051017 ! actin filament bundle assembly [Term] id: GO:0032232 name: negative regulation of actin filament bundle assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "down regulation of actin filament bundle formation" EXACT [] synonym: "down-regulation of actin filament bundle formation" EXACT [] synonym: "downregulation of actin filament bundle formation" EXACT [] synonym: "inhibition of actin filament bundle formation" NARROW [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0051017 ! actin filament bundle assembly [Term] id: GO:0032233 name: positive regulation of actin filament bundle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "activation of actin filament bundle formation" NARROW [] synonym: "stimulation of actin filament bundle formation" NARROW [] synonym: "up regulation of actin filament bundle formation" EXACT [] synonym: "up-regulation of actin filament bundle formation" EXACT [] synonym: "upregulation of actin filament bundle formation" EXACT [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0051017 ! actin filament bundle assembly [Term] id: GO:0032234 name: regulation of calcium ion transport via store-operated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] synonym: "regulation of calcium transport via store-operated calcium channel" EXACT [] synonym: "regulation of store-operated calcium channel activity" EXACT [] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0051924 ! regulation of calcium ion transport [Term] id: GO:0032235 name: negative regulation of calcium ion transport via store-operated calcium channel activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] synonym: "down regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "down-regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "downregulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "inhibition of calcium ion transport via store-operated calcium channel" NARROW [] synonym: "negative regulation of calcium transport via store-operated calcium channel" EXACT [] synonym: "negative regulation of store-operated calcium channel activity" EXACT [] is_a: GO:0032234 ! regulation of calcium ion transport via store-operated calcium channel activity is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:0051926 ! negative regulation of calcium ion transport [Term] id: GO:0032236 name: positive regulation of calcium ion transport via store-operated calcium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] synonym: "activation of calcium ion transport via store-operated calcium channel" NARROW [] synonym: "positive regulation of calcium transport via store-operated calcium channel" EXACT [] synonym: "positive regulation of store-operated calcium channel activity" EXACT [] synonym: "stimulation of calcium ion transport via store-operated calcium channel" NARROW [] synonym: "up regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "up-regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "upregulation of calcium ion transport via store-operated calcium channel" EXACT [] is_a: GO:0032234 ! regulation of calcium ion transport via store-operated calcium channel activity is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:0051928 ! positive regulation of calcium ion transport [Term] id: GO:0032237 name: activation of store-operated calcium channel activity namespace: biological_process def: "A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah] is_a: GO:0032236 ! positive regulation of calcium ion transport via store-operated calcium channel activity [Term] id: GO:0032238 name: adenosine transport namespace: biological_process def: "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] subset: gosubset_prok is_a: GO:0015860 ! purine nucleoside transport [Term] id: GO:0032239 name: regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport [Term] id: GO:0032240 name: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport [Term] id: GO:0032241 name: positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport [Term] id: GO:0032242 name: regulation of nucleoside transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport relationship: regulates GO:0015858 ! nucleoside transport [Term] id: GO:0032243 name: negative regulation of nucleoside transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleoside transport" EXACT [] synonym: "down-regulation of nucleoside transport" EXACT [] synonym: "downregulation of nucleoside transport" EXACT [] synonym: "inhibition of nucleoside transport" NARROW [] is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0032242 ! regulation of nucleoside transport relationship: negatively_regulates GO:0015858 ! nucleoside transport [Term] id: GO:0032244 name: positive regulation of nucleoside transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleoside transport" NARROW [] synonym: "stimulation of nucleoside transport" NARROW [] synonym: "up regulation of nucleoside transport" EXACT [] synonym: "up-regulation of nucleoside transport" EXACT [] synonym: "upregulation of nucleoside transport" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0032242 ! regulation of nucleoside transport relationship: positively_regulates GO:0015858 ! nucleoside transport [Term] id: GO:0032245 name: regulation of purine nucleoside transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032242 ! regulation of nucleoside transport is_a: GO:0034762 ! regulation of transmembrane transport relationship: regulates GO:0015860 ! purine nucleoside transport [Term] id: GO:0032246 name: regulation of pyrimidine nucleoside transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032242 ! regulation of nucleoside transport is_a: GO:0034762 ! regulation of transmembrane transport relationship: regulates GO:0015864 ! pyrimidine nucleoside transport [Term] id: GO:0032247 name: negative regulation of purine nucleoside transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of purine nucleoside transport" EXACT [] synonym: "down-regulation of purine nucleoside transport" EXACT [] synonym: "downregulation of purine nucleoside transport" EXACT [] synonym: "inhibition of purine nucleoside transport" NARROW [] is_a: GO:0032243 ! negative regulation of nucleoside transport is_a: GO:0032245 ! regulation of purine nucleoside transport is_a: GO:0034763 ! negative regulation of transmembrane transport relationship: negatively_regulates GO:0015860 ! purine nucleoside transport [Term] id: GO:0032248 name: positive regulation of purine nucleoside transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of purine nucleoside transport" NARROW [] synonym: "stimulation of purine nucleoside transport" NARROW [] synonym: "up regulation of purine nucleoside transport" EXACT [] synonym: "up-regulation of purine nucleoside transport" EXACT [] synonym: "upregulation of purine nucleoside transport" EXACT [] is_a: GO:0032244 ! positive regulation of nucleoside transport is_a: GO:0032245 ! regulation of purine nucleoside transport is_a: GO:0034764 ! positive regulation of transmembrane transport relationship: positively_regulates GO:0015860 ! purine nucleoside transport [Term] id: GO:0032249 name: regulation of adenosine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032245 ! regulation of purine nucleoside transport relationship: regulates GO:0032238 ! adenosine transport [Term] id: GO:0032250 name: negative regulation of adenosine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of adenosine transport" EXACT [] synonym: "down-regulation of adenosine transport" EXACT [] synonym: "downregulation of adenosine transport" EXACT [] synonym: "inhibition of adenosine transport" NARROW [] is_a: GO:0032247 ! negative regulation of purine nucleoside transport is_a: GO:0032249 ! regulation of adenosine transport relationship: negatively_regulates GO:0032238 ! adenosine transport [Term] id: GO:0032251 name: positive regulation of adenosine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of adenosine transport" NARROW [] synonym: "stimulation of adenosine transport" NARROW [] synonym: "up regulation of adenosine transport" EXACT [] synonym: "up-regulation of adenosine transport" EXACT [] synonym: "upregulation of adenosine transport" EXACT [] is_a: GO:0032248 ! positive regulation of purine nucleoside transport is_a: GO:0032249 ! regulation of adenosine transport relationship: positively_regulates GO:0032238 ! adenosine transport [Term] id: GO:0032252 name: secretory granule localization namespace: biological_process def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "secretory granule clustering" RELATED [] synonym: "secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization [Term] id: GO:0032253 name: dense core granule localization namespace: biological_process def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "dense core granule clustering" RELATED [] synonym: "dense core granule localisation" EXACT [GOC:mah] synonym: "dense core vesicle localization" EXACT [GOC:kmv] is_a: GO:0032252 ! secretory granule localization [Term] id: GO:0032254 name: establishment of secretory granule localization namespace: biological_process def: "The directed movement of a secretory granule to a specific location." [GOC:mah] synonym: "establishment of secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051650 ! establishment of vesicle localization relationship: part_of GO:0032252 ! secretory granule localization [Term] id: GO:0032255 name: maintenance of secretory granule location namespace: biological_process def: "Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of secretory granule localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051655 ! maintenance of vesicle location relationship: part_of GO:0032252 ! secretory granule localization [Term] id: GO:0032256 name: establishment of dense core granule localization namespace: biological_process def: "The directed movement of a dense core granule to a specific location." [GOC:mah] synonym: "establishment of dense core granule localisation" EXACT [GOC:mah] synonym: "establishment of dense core vesicle localization" EXACT [GOC:kmv] is_a: GO:0032254 ! establishment of secretory granule localization relationship: part_of GO:0032253 ! dense core granule localization [Term] id: GO:0032257 name: maintenance of dense core granule location namespace: biological_process def: "Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of dense core granule localization" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of dense core vesicle location" EXACT [GOC:kmv] is_a: GO:0032255 ! maintenance of secretory granule location relationship: part_of GO:0032253 ! dense core granule localization [Term] id: GO:0032258 name: CVT pathway namespace: biological_process def: "A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643] synonym: "cytoplasm to vacuole targeting" EXACT [] synonym: "cytoplasm-to-vacuole targeting" EXACT [] is_a: GO:0006623 ! protein targeting to vacuole [Term] id: GO:0032259 name: methylation namespace: biological_process def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] xref: Reactome:1253085 "Methylation" xref: Reactome:1280020 "Methylation" xref: Reactome:1298906 "Methylation" xref: Reactome:1326590 "Methylation" xref: Reactome:1352702 "Methylation" xref: Reactome:1373113 "Methylation" xref: Reactome:1392934 "Methylation" xref: Reactome:1417410 "Methylation" xref: Reactome:1450711 "Methylation" xref: Reactome:1471230 "Methylation" xref: Reactome:1483217 "Methylation" xref: Reactome:1496911 "Methylation" xref: Reactome:1514300 "Methylation" xref: Reactome:1521166 "Methylation" xref: Reactome:1526910 "Methylation" xref: Reactome:1532647 "Methylation" xref: Reactome:1536070 "Methylation" xref: Reactome:1538043 "Methylation" xref: Reactome:1539327 "Methylation" xref: Reactome:1540337 "Methylation" xref: Reactome:156581 "Methylation" xref: Wikipedia:Methylation is_a: GO:0006730 ! one-carbon metabolic process [Term] id: GO:0032260 name: response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:mah] synonym: "response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb] is_a: GO:0009753 ! response to jasmonic acid stimulus relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0032261 name: purine nucleotide salvage namespace: biological_process def: "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis." [GOC:jp] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0032262 name: pyrimidine nucleotide salvage namespace: biological_process def: "Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0008655 ! pyrimidine-containing compound salvage is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0032263 name: GMP salvage namespace: biological_process def: "Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0006177 ! GMP biosynthetic process is_a: GO:0032261 ! purine nucleotide salvage [Term] id: GO:0032264 name: IMP salvage namespace: biological_process def: "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0006188 ! IMP biosynthetic process is_a: GO:0032261 ! purine nucleotide salvage [Term] id: GO:0032265 name: XMP salvage namespace: biological_process def: "Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0032261 ! purine nucleotide salvage [Term] id: GO:0032266 name: phosphatidylinositol-3-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775] synonym: "phosphatidylinositol 3-phosphate binding" EXACT [] synonym: "PtdIns-3-P binding" EXACT [] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0032267 name: tRNA(Ile)-lysidine synthase activity namespace: molecular_function def: "Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine." [PMID:14527414] synonym: "tRNA(Ile)-2-lysyl-cytidine synthase activity" EXACT [] synonym: "tRNA(Ile)-lysidine synthetase activity" EXACT [] xref: EC:6.3.4.- is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0032268 name: regulation of cellular protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] subset: gosubset_prok synonym: "regulation of cellular protein metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process relationship: regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032269 name: negative regulation of cellular protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032270 name: positive regulation of cellular protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process relationship: positively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032271 name: regulation of protein polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "regulation of protein polymerisation" EXACT [] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0051258 ! protein polymerization [Term] id: GO:0032272 name: negative regulation of protein polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "down regulation of protein polymerization" EXACT [] synonym: "down-regulation of protein polymerization" EXACT [] synonym: "downregulation of protein polymerization" EXACT [] synonym: "inhibition of protein polymerization" NARROW [] is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0051258 ! protein polymerization [Term] id: GO:0032273 name: positive regulation of protein polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "activation of protein polymerization" NARROW [] synonym: "stimulation of protein polymerization" NARROW [] synonym: "up regulation of protein polymerization" EXACT [] synonym: "up-regulation of protein polymerization" EXACT [] synonym: "upregulation of protein polymerization" EXACT [] is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0051258 ! protein polymerization [Term] id: GO:0032274 name: gonadotropin secretion namespace: biological_process def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "gonadotrophin secretion" EXACT [] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0032275 name: luteinizing hormone secretion namespace: biological_process def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0032274 ! gonadotropin secretion [Term] id: GO:0032276 name: regulation of gonadotropin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "regulation of gonadotrophin secretion" EXACT [] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0032274 ! gonadotropin secretion [Term] id: GO:0032277 name: negative regulation of gonadotropin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "down regulation of gonadotropin secretion" EXACT [] synonym: "down-regulation of gonadotropin secretion" EXACT [] synonym: "downregulation of gonadotropin secretion" EXACT [] synonym: "inhibition of gonadotropin secretion" NARROW [] synonym: "negative regulation of gonadotrophin secretion" EXACT [] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046888 ! negative regulation of hormone secretion relationship: negatively_regulates GO:0032274 ! gonadotropin secretion [Term] id: GO:0032278 name: positive regulation of gonadotropin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "activation of gonadotropin secretion" NARROW [] synonym: "positive regulation of gonadotrophin secretion" EXACT [] synonym: "stimulation of gonadotropin secretion" NARROW [] synonym: "up regulation of gonadotropin secretion" EXACT [] synonym: "up-regulation of gonadotropin secretion" EXACT [] synonym: "upregulation of gonadotropin secretion" EXACT [] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046887 ! positive regulation of hormone secretion relationship: positively_regulates GO:0032274 ! gonadotropin secretion [Term] id: GO:0032279 name: asymmetric synapse namespace: cellular_component def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density." [GOC:dgh, GOC:ef] is_a: GO:0045202 ! synapse [Term] id: GO:0032280 name: symmetric synapse namespace: cellular_component def: "A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density." [GOC:dgh, GOC:ef] is_a: GO:0045202 ! synapse [Term] id: GO:0032281 name: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef] synonym: "AMPA receptor " RELATED [] synonym: "AMPA-selective glutamate receptor complex" EXACT [] is_a: GO:0008328 ! ionotropic glutamate receptor complex [Term] id: GO:0032282 name: plastid acetyl-CoA carboxylase complex namespace: cellular_component def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah] synonym: "plastid ACCase complex" EXACT [] is_a: GO:0009317 ! acetyl-CoA carboxylase complex is_a: GO:0044435 ! plastid part relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0032283 name: plastid acetate CoA-transferase complex namespace: cellular_component def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah] is_a: GO:0009329 ! acetate CoA-transferase complex is_a: GO:0044435 ! plastid part relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex [Term] id: GO:0032284 name: plastid biotin carboxylase complex namespace: cellular_component def: "A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah] is_a: GO:0009343 ! biotin carboxylase complex is_a: GO:0044435 ! plastid part relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex [Term] id: GO:0032285 name: non-myelinated axon ensheathment namespace: biological_process def: "The process in which a non-myelinating glial cell membrane closes around an axon." [GOC:dgh] synonym: "ensheathment of non-myelinated axons" EXACT [GOC:curators] is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0032286 name: central nervous system myelin maintenance namespace: biological_process def: "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state." [GOC:dgh] synonym: "myelin maintenance in central nervous system" EXACT [GOC:curators] is_a: GO:0043217 ! myelin maintenance relationship: part_of GO:0022010 ! central nervous system myelination [Term] id: GO:0032287 name: peripheral nervous system myelin maintenance namespace: biological_process def: "The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state." [GOC:dgh] synonym: "myelin maintenance in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0043217 ! myelin maintenance relationship: part_of GO:0022011 ! myelination in peripheral nervous system [Term] id: GO:0032288 name: myelin assembly namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb] synonym: "myelin formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0042552 ! myelination [Term] id: GO:0032289 name: central nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh] synonym: "myelin formation in central nervous system" EXACT [GOC:curators] is_a: GO:0032288 ! myelin assembly relationship: part_of GO:0022010 ! central nervous system myelination [Term] id: GO:0032290 name: peripheral nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the peripheral nervous system." [GOC:dgh] synonym: "myelin formation in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0032288 ! myelin assembly relationship: part_of GO:0022011 ! myelination in peripheral nervous system [Term] id: GO:0032291 name: axon ensheathment in central nervous system namespace: biological_process def: "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in central nervous system" EXACT [GOC:curators] is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0032292 name: peripheral nervous system axon ensheathment namespace: biological_process def: "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0032293 name: non-myelinated axon ensheathment in central nervous system namespace: biological_process def: "The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system." [GOC:dgh] synonym: "ensheathment of non-myelinated axons in central nervous system" EXACT [GOC:curators] is_a: GO:0032285 ! non-myelinated axon ensheathment is_a: GO:0032291 ! axon ensheathment in central nervous system [Term] id: GO:0032294 name: peripheral nervous system non-myelinated axon ensheathment namespace: biological_process def: "The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons." [GOC:dgh] synonym: "ensheathment of non-myelinated axons in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0032285 ! non-myelinated axon ensheathment is_a: GO:0032292 ! peripheral nervous system axon ensheathment [Term] id: GO:0032295 name: ensheathment of neuronal cell bodies namespace: biological_process def: "The process in which satellite glial cells isolate neuronal cell bodies." [GOC:dgh] is_a: GO:0007272 ! ensheathment of neurons [Term] id: GO:0032296 name: double-stranded RNA-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules." [GOC:mah] synonym: "double-stranded RNA-specific RNase activity" EXACT [] synonym: "dsRNA-specific ribonuclease activity" EXACT [] synonym: "dsRNA-specific RNase activity" EXACT [] is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0032297 name: negative regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah] synonym: "down regulation of DNA replication initiation" EXACT [] synonym: "down-regulation of DNA replication initiation" EXACT [] synonym: "downregulation of DNA replication initiation" EXACT [] synonym: "inhibition of DNA replication initiation" NARROW [] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication relationship: negatively_regulates GO:0006270 ! DNA-dependent DNA replication initiation [Term] id: GO:0032298 name: positive regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah] synonym: "activation of DNA replication initiation" NARROW [] synonym: "stimulation of DNA replication initiation" NARROW [] synonym: "up regulation of DNA replication initiation" EXACT [] synonym: "up-regulation of DNA replication initiation" EXACT [] synonym: "upregulation of DNA replication initiation" EXACT [] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:0045740 ! positive regulation of DNA replication relationship: positively_regulates GO:0006270 ! DNA-dependent DNA replication initiation [Term] id: GO:0032299 name: ribonuclease H2 complex namespace: cellular_component def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815] synonym: "RNase H2 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032300 name: mismatch repair complex namespace: cellular_component def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032301 name: MutSalpha complex namespace: cellular_component def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803] synonym: "MMR complex" BROAD [] synonym: "MSH2/MSH6 complex" EXACT [] is_a: GO:0032300 ! mismatch repair complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032302 name: MutSbeta complex namespace: cellular_component def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803] synonym: "MMR complex" BROAD [] synonym: "MSH2/MSH3 complex" EXACT [] is_a: GO:0032300 ! mismatch repair complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032303 name: regulation of icosanoid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell or group of cells." [GOC:mah] synonym: "regulation of eicosanoid secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:2000191 ! regulation of fatty acid transport relationship: regulates GO:0032309 ! icosanoid secretion [Term] id: GO:0032304 name: negative regulation of icosanoid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell or group of cells." [GOC:mah] synonym: "down regulation of icosanoid secretion" EXACT [] synonym: "down-regulation of icosanoid secretion" EXACT [] synonym: "downregulation of icosanoid secretion" EXACT [] synonym: "inhibition of icosanoid secretion" NARROW [] synonym: "negative regulation of eicosanoid secretion" EXACT [] is_a: GO:0032303 ! regulation of icosanoid secretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:2000192 ! negative regulation of fatty acid transport relationship: negatively_regulates GO:0032309 ! icosanoid secretion [Term] id: GO:0032305 name: positive regulation of icosanoid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell or group of cells." [GOC:mah] synonym: "activation of icosanoid secretion" NARROW [] synonym: "positive regulation of eicosanoid secretion" EXACT [] synonym: "stimulation of icosanoid secretion" NARROW [] synonym: "up regulation of icosanoid secretion" EXACT [] synonym: "up-regulation of icosanoid secretion" EXACT [] synonym: "upregulation of icosanoid secretion" EXACT [] is_a: GO:0032303 ! regulation of icosanoid secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:2000193 ! positive regulation of fatty acid transport relationship: positively_regulates GO:0032309 ! icosanoid secretion [Term] id: GO:0032306 name: regulation of prostaglandin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:mah] synonym: "regulation of prostacyclin secretion" NARROW [] is_a: GO:0032303 ! regulation of icosanoid secretion relationship: regulates GO:0032310 ! prostaglandin secretion [Term] id: GO:0032307 name: negative regulation of prostaglandin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:mah] synonym: "down regulation of prostaglandin secretion" EXACT [] synonym: "down-regulation of prostaglandin secretion" EXACT [] synonym: "downregulation of prostaglandin secretion" EXACT [] synonym: "inhibition of prostaglandin secretion" NARROW [] synonym: "negative regulation of prostacyclin secretion" NARROW [] is_a: GO:0032304 ! negative regulation of icosanoid secretion is_a: GO:0032306 ! regulation of prostaglandin secretion relationship: negatively_regulates GO:0032310 ! prostaglandin secretion [Term] id: GO:0032308 name: positive regulation of prostaglandin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:mah] synonym: "activation of prostaglandin secretion" NARROW [] synonym: "positive regulation of prostacyclin secretion" NARROW [] synonym: "stimulation of prostaglandin secretion" NARROW [] synonym: "up regulation of prostaglandin secretion" EXACT [] synonym: "up-regulation of prostaglandin secretion" EXACT [] synonym: "upregulation of prostaglandin secretion" EXACT [] is_a: GO:0032305 ! positive regulation of icosanoid secretion is_a: GO:0032306 ! regulation of prostaglandin secretion relationship: positively_regulates GO:0032310 ! prostaglandin secretion [Term] id: GO:0032309 name: icosanoid secretion namespace: biological_process def: "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:mah] synonym: "eicosanoid secretion" EXACT [] is_a: GO:0046903 ! secretion is_a: GO:0071715 ! icosanoid transport [Term] id: GO:0032310 name: prostaglandin secretion namespace: biological_process def: "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:mah] synonym: "prostacyclin secretion" NARROW [] is_a: GO:0015732 ! prostaglandin transport is_a: GO:0032309 ! icosanoid secretion [Term] id: GO:0032311 name: angiogenin-PRI complex namespace: cellular_component def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787] synonym: "angiogenin-placental ribonuclease inhibitor complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part [Term] id: GO:0032312 name: regulation of ARF GTPase activity namespace: biological_process def: "Any process that modulates the activity of the GTPase ARF." [GOC:mah] is_a: GO:0032318 ! regulation of Ras GTPase activity relationship: part_of GO:0032012 ! regulation of ARF protein signal transduction [Term] id: GO:0032313 name: regulation of Rab GTPase activity namespace: biological_process def: "Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah] is_a: GO:0032318 ! regulation of Ras GTPase activity relationship: part_of GO:0032483 ! regulation of Rab protein signal transduction [Term] id: GO:0032314 name: regulation of Rac GTPase activity namespace: biological_process def: "Any process that modulates the activity of a GTPase of the Rac family." [GOC:mah] is_a: GO:0032319 ! regulation of Rho GTPase activity relationship: part_of GO:0035020 ! regulation of Rac protein signal transduction [Term] id: GO:0032315 name: regulation of Ral GTPase activity namespace: biological_process def: "Any process that modulates the activity of a GTPase of the Ral family." [GOC:mah] is_a: GO:0032318 ! regulation of Ras GTPase activity relationship: part_of GO:0032485 ! regulation of Ral protein signal transduction [Term] id: GO:0032316 name: regulation of Ran GTPase activity namespace: biological_process def: "Any process that modulates the activity of a GTPase of the Ran family." [GOC:mah] is_a: GO:0032318 ! regulation of Ras GTPase activity relationship: part_of GO:0032015 ! regulation of Ran protein signal transduction [Term] id: GO:0032317 name: regulation of Rap GTPase activity namespace: biological_process def: "Any process that modulates the activity of a GTPase of the Rap family." [GOC:mah] is_a: GO:0032318 ! regulation of Ras GTPase activity relationship: part_of GO:0032487 ! regulation of Rap protein signal transduction [Term] id: GO:0032318 name: regulation of Ras GTPase activity namespace: biological_process def: "Any process that modulates the activity of a GTPase of the Ras superfamily." [GOC:mah] is_a: GO:0043087 ! regulation of GTPase activity relationship: part_of GO:0046578 ! regulation of Ras protein signal transduction [Term] id: GO:0032319 name: regulation of Rho GTPase activity namespace: biological_process def: "Any process that modulates the activity of a GTPase of the Rho family." [GOC:mah] is_a: GO:0032318 ! regulation of Ras GTPase activity relationship: part_of GO:0035023 ! regulation of Rho protein signal transduction [Term] id: GO:0032320 name: positive regulation of Ras GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of a GTPase of the Ras superfamily." [GOC:mah] synonym: "stimulation of Ras GTPase activity" NARROW [] synonym: "up regulation of Ras GTPase activity" EXACT [] synonym: "up-regulation of Ras GTPase activity" EXACT [] synonym: "upregulation of Ras GTPase activity" EXACT [] is_a: GO:0032318 ! regulation of Ras GTPase activity is_a: GO:0043547 ! positive regulation of GTPase activity [Term] id: GO:0032321 name: positive regulation of Rho GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of a GTPase of the Rho family." [GOC:mah] synonym: "stimulation of Rho GTPase activity" NARROW [] synonym: "up regulation of Rho GTPase activity" EXACT [] synonym: "up-regulation of Rho GTPase activity" EXACT [] synonym: "upregulation of Rho GTPase activity" EXACT [] is_a: GO:0032319 ! regulation of Rho GTPase activity is_a: GO:0032320 ! positive regulation of Ras GTPase activity [Term] id: GO:0032322 name: ubiquinone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] synonym: "ubiquinone breakdown" EXACT [] synonym: "ubiquinone catabolism" EXACT [] synonym: "ubiquinone degradation" EXACT [] is_a: GO:0006743 ! ubiquinone metabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042378 ! quinone cofactor catabolic process [Term] id: GO:0032323 name: lipoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipoate." [GOC:mah] synonym: "lipoic acid breakdown" EXACT [] synonym: "lipoic acid catabolism" EXACT [] synonym: "lipoic acid degradation" EXACT [] is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0009106 ! lipoate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0032324 name: molybdopterin cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] synonym: "molybdopterin cofactor anabolism" EXACT [] synonym: "molybdopterin cofactor biosynthesis" RELATED [] synonym: "molybdopterin cofactor formation" RELATED [] synonym: "molybdopterin cofactor synthesis" EXACT [] xref: Reactome:947581 "Molybdenum cofactor biosynthesis" is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0043545 ! molybdopterin cofactor metabolic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0032325 name: molybdopterin cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] is_a: GO:0042560 ! pteridine-containing compound catabolic process is_a: GO:0043545 ! molybdopterin cofactor metabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0032326 name: Mo-molybdopterin cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [GOC:mah] subset: gosubset_prok synonym: "Mo-molybdopterin cofactor breakdown" EXACT [] synonym: "Mo-molybdopterin cofactor catabolism" EXACT [] synonym: "Mo-molybdopterin cofactor degradation" EXACT [] synonym: "Moco catabolic process" BROAD [] synonym: "Moco catabolism" BROAD [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process is_a: GO:0032325 ! molybdopterin cofactor catabolic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process [Term] id: GO:0032327 name: W-molybdopterin cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [GOC:mah] subset: gosubset_prok synonym: "Moco catabolic process" BROAD [] synonym: "Moco catabolism" BROAD [] synonym: "W-molybdopterin cofactor breakdown" EXACT [] synonym: "W-molybdopterin cofactor catabolism" EXACT [] synonym: "W-molybdopterin cofactor degradation" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0032325 ! molybdopterin cofactor catabolic process is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process [Term] id: GO:0032328 name: alanine transport namespace: biological_process def: "The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0032329 name: serine transport namespace: biological_process def: "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0032330 name: regulation of chondrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0061035 ! regulation of cartilage development relationship: regulates GO:0002062 ! chondrocyte differentiation [Term] id: GO:0032331 name: negative regulation of chondrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "down regulation of chondrocyte differentiation" EXACT [] synonym: "down-regulation of chondrocyte differentiation" EXACT [] synonym: "downregulation of chondrocyte differentiation" EXACT [] synonym: "inhibition of chondrocyte differentiation" NARROW [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045596 ! negative regulation of cell differentiation relationship: negatively_regulates GO:0002062 ! chondrocyte differentiation [Term] id: GO:0032332 name: positive regulation of chondrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "activation of chondrocyte differentiation" NARROW [] synonym: "stimulation of chondrocyte differentiation" NARROW [] synonym: "up regulation of chondrocyte differentiation" EXACT [] synonym: "up-regulation of chondrocyte differentiation" EXACT [] synonym: "upregulation of chondrocyte differentiation" EXACT [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045597 ! positive regulation of cell differentiation relationship: positively_regulates GO:0002062 ! chondrocyte differentiation [Term] id: GO:0032333 name: activin secretion namespace: biological_process def: "The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [GOC:mah] is_a: GO:0046879 ! hormone secretion [Term] id: GO:0032334 name: inhibin secretion namespace: biological_process def: "The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [GOC:mah] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0032335 name: regulation of activin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell or group of cells." [GOC:mah] is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0032333 ! activin secretion [Term] id: GO:0032336 name: negative regulation of activin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell or group of cells." [GOC:mah] synonym: "down regulation of activin secretion" EXACT [] synonym: "down-regulation of activin secretion" EXACT [] synonym: "downregulation of activin secretion" EXACT [] synonym: "inhibition of activin secretion" NARROW [] is_a: GO:0032335 ! regulation of activin secretion is_a: GO:0046888 ! negative regulation of hormone secretion relationship: negatively_regulates GO:0032333 ! activin secretion [Term] id: GO:0032337 name: positive regulation of activin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell or group of cells." [GOC:mah] synonym: "activation of activin secretion" NARROW [] synonym: "stimulation of activin secretion" NARROW [] synonym: "up regulation of activin secretion" EXACT [] synonym: "up-regulation of activin secretion" EXACT [] synonym: "upregulation of activin secretion" EXACT [] is_a: GO:0032335 ! regulation of activin secretion is_a: GO:0046887 ! positive regulation of hormone secretion relationship: positively_regulates GO:0032333 ! activin secretion [Term] id: GO:0032338 name: regulation of inhibin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells." [GOC:mah] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0032334 ! inhibin secretion [Term] id: GO:0032339 name: negative regulation of inhibin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells." [GOC:mah] synonym: "down regulation of inhibin secretion" EXACT [] synonym: "down-regulation of inhibin secretion" EXACT [] synonym: "downregulation of inhibin secretion" EXACT [] synonym: "inhibition of inhibin secretion" NARROW [] is_a: GO:0032338 ! regulation of inhibin secretion is_a: GO:0046888 ! negative regulation of hormone secretion relationship: negatively_regulates GO:0032334 ! inhibin secretion [Term] id: GO:0032340 name: positive regulation of inhibin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells." [GOC:mah] synonym: "activation of inhibin secretion" NARROW [] synonym: "stimulation of inhibin secretion" NARROW [] synonym: "up regulation of inhibin secretion" EXACT [] synonym: "up-regulation of inhibin secretion" EXACT [] synonym: "upregulation of inhibin secretion" EXACT [] is_a: GO:0032338 ! regulation of inhibin secretion is_a: GO:0046887 ! positive regulation of hormone secretion relationship: positively_regulates GO:0032334 ! inhibin secretion [Term] id: GO:0032341 name: aldosterone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] synonym: "aldosterone metabolism" EXACT [] is_a: GO:0008212 ! mineralocorticoid metabolic process [Term] id: GO:0032342 name: aldosterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] is_a: GO:0006705 ! mineralocorticoid biosynthetic process is_a: GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032343 name: aldosterone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] is_a: GO:0006712 ! mineralocorticoid catabolic process is_a: GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032344 name: regulation of aldosterone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "regulation of aldosterone metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: regulates GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032345 name: negative regulation of aldosterone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "down regulation of aldosterone metabolic process" EXACT [] synonym: "down-regulation of aldosterone metabolic process" EXACT [] synonym: "downregulation of aldosterone metabolic process" EXACT [] synonym: "inhibition of aldosterone metabolic process" NARROW [] synonym: "negative regulation of aldosterone metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process relationship: negatively_regulates GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032346 name: positive regulation of aldosterone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "activation of aldosterone metabolic process" NARROW [] synonym: "positive regulation of aldosterone metabolism" EXACT [] synonym: "stimulation of aldosterone metabolic process" NARROW [] synonym: "up regulation of aldosterone metabolic process" EXACT [] synonym: "up-regulation of aldosterone metabolic process" EXACT [] synonym: "upregulation of aldosterone metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process relationship: positively_regulates GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032347 name: regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process relationship: regulates GO:0032342 ! aldosterone biosynthetic process [Term] id: GO:0032348 name: negative regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] synonym: "down regulation of aldosterone biosynthetic process" EXACT [] synonym: "down-regulation of aldosterone biosynthetic process" EXACT [] synonym: "downregulation of aldosterone biosynthetic process" EXACT [] synonym: "inhibition of aldosterone biosynthetic process" NARROW [] is_a: GO:0032345 ! negative regulation of aldosterone metabolic process is_a: GO:0032347 ! regulation of aldosterone biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process relationship: negatively_regulates GO:0032342 ! aldosterone biosynthetic process [Term] id: GO:0032349 name: positive regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] synonym: "activation of aldosterone biosynthetic process" NARROW [] synonym: "stimulation of aldosterone biosynthetic process" NARROW [] synonym: "up regulation of aldosterone biosynthetic process" EXACT [] synonym: "up-regulation of aldosterone biosynthetic process" EXACT [] synonym: "upregulation of aldosterone biosynthetic process" EXACT [] is_a: GO:0032346 ! positive regulation of aldosterone metabolic process is_a: GO:0032347 ! regulation of aldosterone biosynthetic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process relationship: positively_regulates GO:0032342 ! aldosterone biosynthetic process [Term] id: GO:0032350 name: regulation of hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "regulation of hormone metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032351 name: negative regulation of hormone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "down regulation of hormone metabolic process" EXACT [] synonym: "down-regulation of hormone metabolic process" EXACT [] synonym: "downregulation of hormone metabolic process" EXACT [] synonym: "inhibition of hormone metabolic process" NARROW [] synonym: "negative regulation of hormone metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: negatively_regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032352 name: positive regulation of hormone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "activation of hormone metabolic process" NARROW [] synonym: "positive regulation of hormone metabolism" EXACT [] synonym: "stimulation of hormone metabolic process" NARROW [] synonym: "up regulation of hormone metabolic process" EXACT [] synonym: "up-regulation of hormone metabolic process" EXACT [] synonym: "upregulation of hormone metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: positively_regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032353 name: negative regulation of hormone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "down regulation of hormone biosynthetic process" EXACT [] synonym: "down-regulation of hormone biosynthetic process" EXACT [] synonym: "downregulation of hormone biosynthetic process" EXACT [] synonym: "inhibition of hormone biosynthetic process" NARROW [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process relationship: negatively_regulates GO:0042446 ! hormone biosynthetic process [Term] id: GO:0032354 name: response to follicle-stimulating hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah] synonym: "response to follicle stimulating hormone stimulus" EXACT [] synonym: "response to FSH stimulus" EXACT [] is_a: GO:0034698 ! response to gonadotropin stimulus [Term] id: GO:0032355 name: response to estradiol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123] synonym: "response to E2 stimulus" EXACT [] is_a: GO:0043627 ! response to estrogen stimulus [Term] id: GO:0032356 name: oxidized DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxidized residues in DNA." [GOC:vk] synonym: "oxidised DNA binding" EXACT [] is_a: GO:0003684 ! damaged DNA binding [Term] id: GO:0032357 name: oxidized purine DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxidized purine residues in DNA." [GOC:vk] synonym: "oxidised purine DNA binding" EXACT [] synonym: "oxidized purine base DNA binding" EXACT [CHEBI:26386] synonym: "oxidized purine nucleobase DNA binding" EXACT [CHEBI:26386] is_a: GO:0032356 ! oxidized DNA binding [Term] id: GO:0032358 name: oxidized pyrimidine DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxidized pyrimidine residues in DNA." [GOC:vk] synonym: "oxidised pyrimidine DNA binding" EXACT [] synonym: "oxidized pyrimidine base DNA binding" EXACT [CHEBI:26432] synonym: "oxidized pyrimidine nucleobase DNA binding" EXACT [CHEBI:26432] is_a: GO:0032356 ! oxidized DNA binding [Term] id: GO:0032359 name: provirus excision namespace: biological_process def: "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg] synonym: "prophage excision" EXACT [] is_a: GO:0022415 ! viral reproductive process [Term] id: GO:0032360 name: provirus maintenance namespace: biological_process def: "The molecular events that maintain a viral genome integrated into a host genome." [GOC:mlg] synonym: "prophage maintenance" EXACT [] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0030069 ! lysogeny [Term] id: GO:0032361 name: pyridoxal phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah] is_a: GO:0042820 ! vitamin B6 catabolic process is_a: GO:0042822 ! pyridoxal phosphate metabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0032362 name: FAD catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of FAD, the oxidized form of flavin-adenine dinucleotide." [CHEBI:16238, GOC:mah] synonym: "FAD breakdown" EXACT [GOC:mah] synonym: "FAD catabolism" EXACT [GOC:mah] synonym: "FAD degradation" EXACT [GOC:mah] synonym: "oxidized flavin adenine dinucleotide catabolic process" EXACT [GOC:mah] is_a: GO:0046443 ! FAD metabolic process is_a: GO:0072389 ! flavin adenine dinucleotide catabolic process [Term] id: GO:0032363 name: FMN catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process is_a: GO:0046444 ! FMN metabolic process [Term] id: GO:0032364 name: oxygen homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell." [GOC:rph] is_a: GO:0033483 ! gas homeostasis [Term] id: GO:0032365 name: intracellular lipid transport namespace: biological_process def: "The directed movement of lipids within cells." [GOC:mah] is_a: GO:0006869 ! lipid transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0032366 name: intracellular sterol transport namespace: biological_process def: "The directed movement of sterols within cells." [GOC:mah] is_a: GO:0015918 ! sterol transport is_a: GO:0032365 ! intracellular lipid transport [Term] id: GO:0032367 name: intracellular cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah] is_a: GO:0030301 ! cholesterol transport is_a: GO:0032366 ! intracellular sterol transport [Term] id: GO:0032368 name: regulation of lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0006869 ! lipid transport [Term] id: GO:0032369 name: negative regulation of lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of lipid transport" EXACT [] synonym: "down-regulation of lipid transport" EXACT [] synonym: "downregulation of lipid transport" EXACT [] synonym: "inhibition of lipid transport" NARROW [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0006869 ! lipid transport [Term] id: GO:0032370 name: positive regulation of lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of lipid transport" NARROW [] synonym: "stimulation of lipid transport" NARROW [] synonym: "up regulation of lipid transport" EXACT [] synonym: "up-regulation of lipid transport" EXACT [] synonym: "upregulation of lipid transport" EXACT [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0006869 ! lipid transport [Term] id: GO:0032371 name: regulation of sterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport relationship: regulates GO:0015918 ! sterol transport [Term] id: GO:0032372 name: negative regulation of sterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of sterol transport" EXACT [] synonym: "down-regulation of sterol transport" EXACT [] synonym: "downregulation of sterol transport" EXACT [] synonym: "inhibition of sterol transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032371 ! regulation of sterol transport relationship: negatively_regulates GO:0015918 ! sterol transport [Term] id: GO:0032373 name: positive regulation of sterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of sterol transport" NARROW [] synonym: "stimulation of sterol transport" NARROW [] synonym: "up regulation of sterol transport" EXACT [] synonym: "up-regulation of sterol transport" EXACT [] synonym: "upregulation of sterol transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032371 ! regulation of sterol transport relationship: positively_regulates GO:0015918 ! sterol transport [Term] id: GO:0032374 name: regulation of cholesterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032371 ! regulation of sterol transport relationship: regulates GO:0030301 ! cholesterol transport [Term] id: GO:0032375 name: negative regulation of cholesterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of cholesterol transport" EXACT [] synonym: "down-regulation of cholesterol transport" EXACT [] synonym: "downregulation of cholesterol transport" EXACT [] synonym: "inhibition of cholesterol transport" NARROW [] is_a: GO:0032372 ! negative regulation of sterol transport is_a: GO:0032374 ! regulation of cholesterol transport relationship: negatively_regulates GO:0030301 ! cholesterol transport [Term] id: GO:0032376 name: positive regulation of cholesterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of cholesterol transport" NARROW [] synonym: "stimulation of cholesterol transport" NARROW [] synonym: "up regulation of cholesterol transport" EXACT [] synonym: "up-regulation of cholesterol transport" EXACT [] synonym: "upregulation of cholesterol transport" EXACT [] is_a: GO:0032373 ! positive regulation of sterol transport is_a: GO:0032374 ! regulation of cholesterol transport relationship: positively_regulates GO:0030301 ! cholesterol transport [Term] id: GO:0032377 name: regulation of intracellular lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032386 ! regulation of intracellular transport relationship: regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032378 name: negative regulation of intracellular lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "down regulation of intracellular lipid transport" EXACT [] synonym: "down-regulation of intracellular lipid transport" EXACT [] synonym: "downregulation of intracellular lipid transport" EXACT [] synonym: "inhibition of intracellular lipid transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032387 ! negative regulation of intracellular transport relationship: negatively_regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032379 name: positive regulation of intracellular lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "activation of intracellular lipid transport" NARROW [] synonym: "stimulation of intracellular lipid transport" NARROW [] synonym: "up regulation of intracellular lipid transport" EXACT [] synonym: "up-regulation of intracellular lipid transport" EXACT [] synonym: "upregulation of intracellular lipid transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032388 ! positive regulation of intracellular transport relationship: positively_regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032380 name: regulation of intracellular sterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] is_a: GO:0032371 ! regulation of sterol transport is_a: GO:0032377 ! regulation of intracellular lipid transport relationship: regulates GO:0032366 ! intracellular sterol transport [Term] id: GO:0032381 name: negative regulation of intracellular sterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] synonym: "down regulation of intracellular sterol transport" EXACT [] synonym: "down-regulation of intracellular sterol transport" EXACT [] synonym: "downregulation of intracellular sterol transport" EXACT [] synonym: "inhibition of intracellular sterol transport" NARROW [] is_a: GO:0032372 ! negative regulation of sterol transport is_a: GO:0032378 ! negative regulation of intracellular lipid transport is_a: GO:0032380 ! regulation of intracellular sterol transport relationship: negatively_regulates GO:0032366 ! intracellular sterol transport [Term] id: GO:0032382 name: positive regulation of intracellular sterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] synonym: "activation of intracellular sterol transport" NARROW [] synonym: "stimulation of intracellular sterol transport" NARROW [] synonym: "up regulation of intracellular sterol transport" EXACT [] synonym: "up-regulation of intracellular sterol transport" EXACT [] synonym: "upregulation of intracellular sterol transport" EXACT [] is_a: GO:0032373 ! positive regulation of sterol transport is_a: GO:0032379 ! positive regulation of intracellular lipid transport is_a: GO:0032380 ! regulation of intracellular sterol transport relationship: positively_regulates GO:0032366 ! intracellular sterol transport [Term] id: GO:0032383 name: regulation of intracellular cholesterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] is_a: GO:0032374 ! regulation of cholesterol transport is_a: GO:0032380 ! regulation of intracellular sterol transport relationship: regulates GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0032384 name: negative regulation of intracellular cholesterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] synonym: "down regulation of intracellular cholesterol transport" EXACT [] synonym: "down-regulation of intracellular cholesterol transport" EXACT [] synonym: "downregulation of intracellular cholesterol transport" EXACT [] synonym: "inhibition of intracellular cholesterol transport" NARROW [] is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:0032381 ! negative regulation of intracellular sterol transport is_a: GO:0032383 ! regulation of intracellular cholesterol transport relationship: negatively_regulates GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0032385 name: positive regulation of intracellular cholesterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] synonym: "activation of intracellular cholesterol transport" NARROW [] synonym: "stimulation of intracellular cholesterol transport" NARROW [] synonym: "up regulation of intracellular cholesterol transport" EXACT [] synonym: "up-regulation of intracellular cholesterol transport" EXACT [] synonym: "upregulation of intracellular cholesterol transport" EXACT [] is_a: GO:0032376 ! positive regulation of cholesterol transport is_a: GO:0032382 ! positive regulation of intracellular sterol transport is_a: GO:0032383 ! regulation of intracellular cholesterol transport relationship: positively_regulates GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0032386 name: regulation of intracellular transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0046907 ! intracellular transport [Term] id: GO:0032387 name: negative regulation of intracellular transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "down regulation of intracellular transport" EXACT [] synonym: "down-regulation of intracellular transport" EXACT [] synonym: "downregulation of intracellular transport" EXACT [] synonym: "inhibition of intracellular transport" NARROW [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032388 name: positive regulation of intracellular transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "activation of intracellular transport" NARROW [] synonym: "stimulation of intracellular transport" NARROW [] synonym: "up regulation of intracellular transport" EXACT [] synonym: "up-regulation of intracellular transport" EXACT [] synonym: "upregulation of intracellular transport" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032389 name: MutLalpha complex namespace: cellular_component def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk] synonym: "MLH1/PMS2 complex" EXACT [] synonym: "MMR complex" BROAD [] synonym: "MutL-alpha complex" EXACT [CORUM:292] is_a: GO:0032300 ! mismatch repair complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032390 name: MutLbeta complex namespace: cellular_component def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk] synonym: "MLH1/PMS1 complex" EXACT [] synonym: "MMR complex" BROAD [] is_a: GO:0032300 ! mismatch repair complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032391 name: photoreceptor connecting cilium namespace: cellular_component def: "A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments." [PMID:15917207, PMID:8718680] synonym: "photoreceptor cilium" RELATED [] is_a: GO:0031513 ! nonmotile primary cilium [Term] id: GO:0032392 name: DNA geometric change namespace: biological_process def: "The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah] comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo. subset: goslim_pir is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0032393 name: MHC class I receptor activity namespace: molecular_function def: "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0032394 name: MHC class Ib receptor activity namespace: molecular_function def: "Combining with an MHC class Ib protein complex to initiate a change in cellular activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0032395 name: MHC class II receptor activity namespace: molecular_function def: "Combining with an MHC class II protein complex to initiate a change in cellular activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0032396 name: inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134] is_a: GO:0032393 ! MHC class I receptor activity [Term] id: GO:0032397 name: activating MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte." [GOC:add, PMID:11858820, PMID:9597134] is_a: GO:0032393 ! MHC class I receptor activity [Term] id: GO:0032398 name: MHC class Ib protein complex namespace: cellular_component def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15928678] is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0032399 name: HECT domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a HECT, 'Homologous to the E6-AP Carboxyl Terminus', domain of a protein." [GOC:mah, Pfam:PF00632] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032400 name: melanosome localization namespace: biological_process def: "Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ln] synonym: "melanosome localisation" EXACT [GOC:mah] is_a: GO:0051875 ! pigment granule localization [Term] id: GO:0032401 name: establishment of melanosome localization namespace: biological_process def: "The directed movement of a melanosome to a specific location." [GOC:mah] synonym: "establishment of melanosome localisation" EXACT [GOC:mah] is_a: GO:0051905 ! establishment of pigment granule localization relationship: part_of GO:0032400 ! melanosome localization [Term] id: GO:0032402 name: melanosome transport namespace: biological_process def: "The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ln] is_a: GO:0032401 ! establishment of melanosome localization is_a: GO:0051904 ! pigment granule transport [Term] id: GO:0032403 name: protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0032404 name: mismatch repair complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mismatch repair complex." [GOC:vk] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0032405 name: MutLalpha complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutLalpha." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032406 name: MutLbeta complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutLbeta." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032407 name: MutSalpha complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutSalpha." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032408 name: MutSbeta complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutSbeta." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032409 name: regulation of transporter activity namespace: biological_process def: "Any process that modulates the activity of a transporter." [GOC:mah] subset: gosubset_prok is_a: GO:0051049 ! regulation of transport is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0032410 name: negative regulation of transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] synonym: "down regulation of transporter activity" EXACT [] synonym: "down-regulation of transporter activity" EXACT [] synonym: "downregulation of transporter activity" EXACT [] synonym: "inhibition of transporter activity" NARROW [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051051 ! negative regulation of transport [Term] id: GO:0032411 name: positive regulation of transporter activity namespace: biological_process def: "Any process that activates or increases the activity of a transporter." [GOC:mah] synonym: "activation of transporter activity" NARROW [] synonym: "stimulation of transporter activity" NARROW [] synonym: "up regulation of transporter activity" EXACT [] synonym: "up-regulation of transporter activity" EXACT [] synonym: "upregulation of transporter activity" EXACT [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051050 ! positive regulation of transport [Term] id: GO:0032412 name: regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb] subset: gosubset_prok synonym: "regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0022898 ! regulation of transmembrane transporter activity is_a: GO:0034765 ! regulation of ion transmembrane transport [Term] id: GO:0032413 name: negative regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "down regulation of ion transporter activity" EXACT [] synonym: "down-regulation of ion transporter activity" EXACT [] synonym: "downregulation of ion transporter activity" EXACT [] synonym: "inhibition of ion transporter activity" NARROW [] synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0032412 ! regulation of ion transmembrane transporter activity [Term] id: GO:0032414 name: positive regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "activation of ion transporter activity" NARROW [] synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] synonym: "stimulation of ion transporter activity" NARROW [] synonym: "up regulation of ion transporter activity" EXACT [] synonym: "up-regulation of ion transporter activity" EXACT [] synonym: "upregulation of ion transporter activity" EXACT [] is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0032412 ! regulation of ion transmembrane transporter activity [Term] id: GO:0032415 name: regulation of sodium:hydrogen antiporter activity namespace: biological_process def: "Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah, GOC:mtg_transport] synonym: "regulation of sodium:proton antiporter activity" EXACT [GOC:mah] is_a: GO:0010155 ! regulation of proton transport is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity [Term] id: GO:0032416 name: negative regulation of sodium:hydrogen antiporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] synonym: "down regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "down-regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "downregulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "inhibition of sodium:hydrogen antiporter activity" NARROW [] synonym: "negative regulation of sodium:proton antiporter activity" EXACT [GOC:mah] is_a: GO:0032415 ! regulation of sodium:hydrogen antiporter activity is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity [Term] id: GO:0032417 name: positive regulation of sodium:hydrogen antiporter activity namespace: biological_process def: "Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] synonym: "activation of sodium:hydrogen antiporter activity" NARROW [] synonym: "positive regulation of sodium:proton antiporter activity" EXACT [GOC:mah] synonym: "stimulation of sodium:hydrogen antiporter activity" NARROW [] synonym: "up regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "up-regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "upregulation of sodium:hydrogen antiporter activity" EXACT [] is_a: GO:0032415 ! regulation of sodium:hydrogen antiporter activity is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity [Term] id: GO:0032418 name: lysosome localization namespace: biological_process def: "Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "lysosome localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0032419 name: extrinsic to lysosome membrane namespace: cellular_component def: "Loosely bound to one surface of the lysosome membrane, but not integrated into the hydrophobic region." [GOC:mah] synonym: "extrinsic to lysosomal membrane" EXACT [] is_a: GO:0000306 ! extrinsic to vacuolar membrane relationship: part_of GO:0005765 ! lysosomal membrane [Term] id: GO:0032420 name: stereocilium namespace: cellular_component def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137] is_a: GO:0005902 ! microvillus is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part relationship: part_of GO:0032421 ! stereocilium bundle [Term] id: GO:0032421 name: stereocilium bundle namespace: cellular_component def: "An actin-based, cross-linked cellular protrusion on the apical surface of auditory and vestibular hair cells. Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137] subset: goslim_pir synonym: "stereocilia bundle" EXACT [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0032422 name: purine-rich negative regulatory element binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411] synonym: "PNR element binding" BROAD [] is_a: GO:0043565 ! sequence-specific DNA binding is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0032423 name: regulation of mismatch repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mismatch repair." [GOC:vk] is_a: GO:0006282 ! regulation of DNA repair relationship: regulates GO:0006298 ! mismatch repair [Term] id: GO:0032424 name: negative regulation of mismatch repair namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair." [GOC:vk] synonym: "down regulation of mismatch repair" EXACT [] synonym: "down-regulation of mismatch repair" EXACT [] synonym: "downregulation of mismatch repair" EXACT [] synonym: "inhibition of mismatch repair" NARROW [] is_a: GO:0032423 ! regulation of mismatch repair is_a: GO:0045738 ! negative regulation of DNA repair relationship: negatively_regulates GO:0006298 ! mismatch repair [Term] id: GO:0032425 name: positive regulation of mismatch repair namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mismatch repair." [GOC:vk] synonym: "activation of mismatch repair" NARROW [] synonym: "stimulation of mismatch repair" NARROW [] synonym: "up regulation of mismatch repair" EXACT [] synonym: "up-regulation of mismatch repair" EXACT [] synonym: "upregulation of mismatch repair" EXACT [] is_a: GO:0032423 ! regulation of mismatch repair is_a: GO:0045739 ! positive regulation of DNA repair relationship: positively_regulates GO:0006298 ! mismatch repair [Term] id: GO:0032426 name: stereocilium bundle tip namespace: cellular_component def: "The end of a stereocilium bundle, distal to the site of the bundle's attachment to the apical cell surface." [GOC:ecd, PMID:17021180] synonym: "stereocilium tip" RELATED [] is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0032421 ! stereocilium bundle [Term] id: GO:0032427 name: GBD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac." [GOC:mah, GOC:pg, PMID:9119069] synonym: "Cdc42/Rac interactive binding motif binding" EXACT [PMID:9119069] synonym: "CRIB motif binding" EXACT [PMID:9119069] synonym: "P21-Rho-binding domain binding" EXACT [GOC:rl] synonym: "PMD binding" EXACT [GOC:rl] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032428 name: beta-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides." [EC:3.2.1.53] synonym: "beta-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53] synonym: "beta-D-N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53] synonym: "beta-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.53] synonym: "N-acetyl-beta-D-galactosaminidase activity" EXACT [EC:3.2.1.53] synonym: "N-acetyl-beta-galactosaminidase activity" EXACT [EC:3.2.1.53] synonym: "N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53] xref: EC:3.2.1.53 xref: MetaCyc:3.2.1.53-RXN is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity [Term] id: GO:0032429 name: regulation of phospholipase A2 activity namespace: biological_process def: "Any process that modulates the activity of the enzyme phospholipase A2." [GOC:mah] is_a: GO:0010517 ! regulation of phospholipase activity [Term] id: GO:0032430 name: positive regulation of phospholipase A2 activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme phospholipase A2." [GOC:mah] synonym: "activation of phospholipase A2 activity" NARROW [] synonym: "stimulation of phospholipase A2 activity" NARROW [] synonym: "up regulation of phospholipase A2 activity" EXACT [] synonym: "up-regulation of phospholipase A2 activity" EXACT [] synonym: "upregulation of phospholipase A2 activity" EXACT [] is_a: GO:0010518 ! positive regulation of phospholipase activity is_a: GO:0032429 ! regulation of phospholipase A2 activity [Term] id: GO:0032431 name: activation of phospholipase A2 activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme phospholipase A2." [GOC:mah] synonym: "phospholipase A2 activation" EXACT [] is_a: GO:0032430 ! positive regulation of phospholipase A2 activity [Term] id: GO:0032432 name: actin filament bundle namespace: cellular_component alt_id: GO:0000141 alt_id: GO:0030482 def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] synonym: "actin cable" RELATED [GOC:mah] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0032433 name: filopodium tip namespace: cellular_component def: "The end of a filopodium distal to the body of the cell." [GOC:mah] is_a: GO:0044463 ! cell projection part relationship: part_of GO:0030175 ! filopodium [Term] id: GO:0032434 name: regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] is_a: GO:0061136 ! regulation of proteasomal protein catabolic process relationship: regulates GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0032435 name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] synonym: "down regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "down-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "downregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "inhibition of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:0045861 ! negative regulation of proteolysis relationship: negatively_regulates GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0032436 name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] synonym: "activation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] synonym: "stimulation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] synonym: "up regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "up-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "upregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:0045862 ! positive regulation of proteolysis relationship: positively_regulates GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0032437 name: cuticular plate namespace: cellular_component def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0032438 name: melanosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk] synonym: "melanosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0032439 name: endosome localization namespace: biological_process def: "Any process in which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd] synonym: "endosome localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0032440 name: 2-alkenal reductase activity namespace: molecular_function def: "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] synonym: "n-alkanal:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.3.1.74] synonym: "NAD(P)H-dependent alkenal/one oxidoreductase activity" EXACT [EC:1.3.1.74] xref: EC:1.3.1.74 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0032441 name: pheophorbide a oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O." [PMID:14657372, PMID:16448336] xref: EC:1.8.-.- xref: MetaCyc:RXN-7740 is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0032442 name: phenylcoumaran benzylic ether reductase activity namespace: molecular_function def: "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP." [PMID:11030549, PMID:13129921] synonym: "PCBER activity" EXACT [] xref: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0032443 name: regulation of ergosterol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process relationship: regulates GO:0006696 ! ergosterol biosynthetic process [Term] id: GO:0032444 name: activin responsive factor complex namespace: cellular_component def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972] comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor). synonym: "ARF complex" EXACT [] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0032445 name: fructose import namespace: biological_process def: "The directed movement of the hexose monosaccharide fructose into a cell or organelle." [GOC:mah] subset: gosubset_prok synonym: "fructose uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015755 ! fructose transport [Term] id: GO:0032446 name: protein modification by small protein conjugation namespace: biological_process def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] is_a: GO:0070647 ! protein modification by small protein conjugation or removal [Term] id: GO:0032447 name: protein urmylation namespace: biological_process def: "Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw] is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0032448 name: DNA hairpin binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0032449 name: CBM complex namespace: cellular_component def: "A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation." [PMID:12909454] synonym: "CARMA1-BCL10-Malt1 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032450 name: maltose alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] synonym: "maltase activity" EXACT [] xref: EC:3.2.1.20 xref: MetaCyc:RXN-2141 is_a: GO:0004558 ! alpha-glucosidase activity [Term] id: GO:0032451 name: demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah] subset: goslim_pir is_a: GO:0003824 ! catalytic activity [Term] id: GO:0032452 name: histone demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from a histone." [GOC:mah] is_a: GO:0032451 ! demethylase activity [Term] id: GO:0032453 name: histone demethylase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein." [GOC:mah] is_a: GO:0032452 ! histone demethylase activity [Term] id: GO:0032454 name: histone demethylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein." [PMID:16362057] xref: Reactome:263737 "histone demethylase activity (H3-K9 specific)" is_a: GO:0032452 ! histone demethylase activity [Term] id: GO:0032455 name: nerve growth factor processing namespace: biological_process def: "The generation of a mature nerve growth factor by proteolysis of a precursor." [GOC:mah, PMID:8615794] xref: Reactome:1253358 "NGF processing" xref: Reactome:1280298 "NGF processing" xref: Reactome:1299149 "NGF processing" xref: Reactome:1326876 "NGF processing" xref: Reactome:1352967 "NGF processing" xref: Reactome:1373169 "NGF processing" xref: Reactome:1393180 "NGF processing" xref: Reactome:1417672 "NGF processing" xref: Reactome:1450774 "NGF processing" xref: Reactome:167060 "NGF processing" is_a: GO:0016486 ! peptide hormone processing [Term] id: GO:0032456 name: endocytic recycling namespace: biological_process def: "The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] synonym: "retrograde transport of endocytic vesicles" RELATED [] is_a: GO:0016197 ! endosome transport [Term] id: GO:0032457 name: fast endocytic recycling namespace: biological_process def: "The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] synonym: "direct endocytic recycling" EXACT [] is_a: GO:0032456 ! endocytic recycling [Term] id: GO:0032458 name: slow endocytic recycling namespace: biological_process def: "The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] is_a: GO:0032456 ! endocytic recycling [Term] id: GO:0032459 name: regulation of protein oligomerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein oligomerization." [GOC:mah] subset: gosubset_prok is_a: GO:0043254 ! regulation of protein complex assembly relationship: regulates GO:0051259 ! protein oligomerization [Term] id: GO:0032460 name: negative regulation of protein oligomerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization." [GOC:mah] subset: gosubset_prok synonym: "down regulation of protein oligomerization" EXACT [] synonym: "down-regulation of protein oligomerization" EXACT [] synonym: "downregulation of protein oligomerization" EXACT [] synonym: "inhibition of protein oligomerization" NARROW [] is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0032459 ! regulation of protein oligomerization relationship: negatively_regulates GO:0051259 ! protein oligomerization [Term] id: GO:0032461 name: positive regulation of protein oligomerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein oligomerization." [GOC:mah] subset: gosubset_prok synonym: "activation of protein oligomerization" NARROW [] synonym: "induction of protein oligomerization" RELATED [] synonym: "stimulation of protein oligomerization" NARROW [] synonym: "up regulation of protein oligomerization" EXACT [] synonym: "up-regulation of protein oligomerization" EXACT [] synonym: "upregulation of protein oligomerization" EXACT [] is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0032459 ! regulation of protein oligomerization relationship: positively_regulates GO:0051259 ! protein oligomerization [Term] id: GO:0032462 name: regulation of protein homooligomerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein homooligomerization." [GOC:mah] subset: gosubset_prok is_a: GO:0032459 ! regulation of protein oligomerization relationship: regulates GO:0051260 ! protein homooligomerization [Term] id: GO:0032463 name: negative regulation of protein homooligomerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization." [GOC:mah] subset: gosubset_prok synonym: "down regulation of protein homooligomerization" EXACT [] synonym: "down-regulation of protein homooligomerization" EXACT [] synonym: "downregulation of protein homooligomerization" EXACT [] synonym: "inhibition of protein homooligomerization" NARROW [] is_a: GO:0032460 ! negative regulation of protein oligomerization is_a: GO:0032462 ! regulation of protein homooligomerization relationship: negatively_regulates GO:0051260 ! protein homooligomerization [Term] id: GO:0032464 name: positive regulation of protein homooligomerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein homooligomerization." [GOC:mah] subset: gosubset_prok synonym: "activation of protein homooligomerization" NARROW [] synonym: "induction of protein homooligomerization" RELATED [] synonym: "stimulation of protein homooligomerization" NARROW [] synonym: "up regulation of protein homooligomerization" EXACT [] synonym: "up-regulation of protein homooligomerization" EXACT [] synonym: "upregulation of protein homooligomerization" EXACT [] is_a: GO:0032461 ! positive regulation of protein oligomerization is_a: GO:0032462 ! regulation of protein homooligomerization relationship: positively_regulates GO:0051260 ! protein homooligomerization [Term] id: GO:0032465 name: regulation of cytokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] is_a: GO:0051302 ! regulation of cell division relationship: regulates GO:0000910 ! cytokinesis [Term] id: GO:0032466 name: negative regulation of cytokinesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytokinesis." [GOC:mah] synonym: "down regulation of cytokinesis" EXACT [] synonym: "down-regulation of cytokinesis" EXACT [] synonym: "downregulation of cytokinesis" EXACT [] synonym: "inhibition of cytokinesis" NARROW [] is_a: GO:0032465 ! regulation of cytokinesis is_a: GO:0051782 ! negative regulation of cell division relationship: negatively_regulates GO:0000910 ! cytokinesis [Term] id: GO:0032467 name: positive regulation of cytokinesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytokinesis." [GOC:mah] synonym: "activation of cytokinesis" NARROW [] synonym: "stimulation of cytokinesis" NARROW [] synonym: "up regulation of cytokinesis" EXACT [] synonym: "up-regulation of cytokinesis" EXACT [] synonym: "upregulation of cytokinesis" EXACT [] is_a: GO:0032465 ! regulation of cytokinesis is_a: GO:0051781 ! positive regulation of cell division relationship: positively_regulates GO:0000910 ! cytokinesis [Term] id: GO:0032468 name: Golgi calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah] synonym: "calcium ion homeostasis in Golgi" EXACT [] synonym: "Golgi calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in Golgi" EXACT [] synonym: "regulation of Golgi calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0032469 name: endoplasmic reticulum calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah] synonym: "calcium ion homeostasis in endoplasmic reticulum" EXACT [] synonym: "calcium ion homeostasis in ER" EXACT [] synonym: "endoplasmic reticulum calcium ion concentration regulation" EXACT [] synonym: "ER calcium ion concentration regulation" EXACT [] synonym: "ER calcium ion homeostasis" EXACT [] synonym: "regulation of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "regulation of calcium ion concentration in ER" EXACT [] synonym: "regulation of endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "regulation of ER calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0032470 name: elevation of endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] synonym: "elevation of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "elevation of ER calcium ion concentration" EXACT [] synonym: "endoplasmic reticulum calcium ion concentration elevation" EXACT [] is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0032471 name: reduction of endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] synonym: "endoplasmic reticulum calcium ion concentration reduction" EXACT [] synonym: "ER calcium ion concentration reduction" EXACT [] synonym: "reduction of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "reduction of calcium ion concentration in ER" EXACT [] synonym: "reduction of ER calcium ion concentration" EXACT [] is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0032472 name: Golgi calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus." [GOC:mah] synonym: "Golgi calcium transport" EXACT [] is_a: GO:0006816 ! calcium ion transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0032473 name: external side of mitochondrial outer membrane namespace: cellular_component def: "The external (cytoplasmic face) of the mitochondrial outer membrane." [GOC:mah] synonym: "cytosolic side of mitochondrial outer membrane" EXACT [] synonym: "external side of mitochondrial envelope" RELATED [] is_a: GO:0044455 ! mitochondrial membrane part [Term] id: GO:0032474 name: otolith morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an otolith are generated and organized." [GOC:dgh] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0048840 ! otolith development [Term] id: GO:0032475 name: otolith formation namespace: biological_process def: "The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0032474 ! otolith morphogenesis [Term] id: GO:0032476 name: decaprenyl diphosphate synthase complex namespace: cellular_component def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123] subset: goslim_pir is_a: GO:0043234 ! protein complex [Term] id: GO:0032477 name: homodimeric decaprenyl diphosphate synthase complex namespace: cellular_component def: "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [PMID:14519123] is_a: GO:0032476 ! decaprenyl diphosphate synthase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032478 name: heterotetrameric decaprenyl diphosphate synthase complex namespace: cellular_component def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123] is_a: GO:0032476 ! decaprenyl diphosphate synthase complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0032479 name: regulation of type I interferon production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "regulation of type I IFN production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032606 ! type I interferon production [Term] id: GO:0032480 name: negative regulation of type I interferon production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "down regulation of type I interferon production" EXACT [] synonym: "down-regulation of type I interferon production" EXACT [] synonym: "downregulation of type I interferon production" EXACT [] synonym: "inhibition of type I interferon production" NARROW [] synonym: "negative regulation of type I IFN production" EXACT [] xref: Reactome:936440 "Negative regulators of RIG-I/MDA5 signaling" is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032479 ! regulation of type I interferon production relationship: negatively_regulates GO:0032606 ! type I interferon production [Term] id: GO:0032481 name: positive regulation of type I interferon production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "activation of type I interferon production" NARROW [] synonym: "positive regulation of type I IFN production" EXACT [] synonym: "stimulation of type I interferon production" NARROW [] synonym: "up regulation of type I interferon production" EXACT [] synonym: "up-regulation of type I interferon production" EXACT [] synonym: "upregulation of type I interferon production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032479 ! regulation of type I interferon production relationship: positively_regulates GO:0032606 ! type I interferon production [Term] id: GO:0032482 name: Rab protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032483 name: regulation of Rab protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0032482 ! Rab protein signal transduction [Term] id: GO:0032484 name: Ral protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032485 name: regulation of Ral protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Ral protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0032484 ! Ral protein signal transduction [Term] id: GO:0032486 name: Rap protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032487 name: regulation of Rap protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rap protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0032486 ! Rap protein signal transduction [Term] id: GO:0032488 name: Cdc42 protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007266 ! Rho protein signal transduction [Term] id: GO:0032489 name: regulation of Cdc42 protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction." [GOC:mah] is_a: GO:0035023 ! regulation of Rho protein signal transduction relationship: regulates GO:0032488 ! Cdc42 protein signal transduction [Term] id: GO:0032490 name: detection of molecule of bacterial origin namespace: biological_process def: "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal." [GOC:add, GOC:rl] synonym: "detection of bacteria associated molecule" EXACT [] synonym: "detection of bacterial associated molecule" EXACT [] synonym: "detection of bacterium associated molecule" EXACT [] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0032491 name: detection of molecule of fungal origin namespace: biological_process def: "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] synonym: "detection of fungal associated molecule" EXACT [] synonym: "detection of fungus associated molecule" EXACT [] is_a: GO:0002238 ! response to molecule of fungal origin is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0032492 name: detection of molecule of oomycetes origin namespace: biological_process def: "The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] synonym: "detection of oomycetes associated molecule" EXACT [] is_a: GO:0002240 ! response to molecule of oomycetes origin is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0032493 name: response to bacterial lipoprotein namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:add, PMID:12077222] is_a: GO:0002237 ! response to molecule of bacterial origin [Term] id: GO:0032494 name: response to peptidoglycan namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] is_a: GO:0002237 ! response to molecule of bacterial origin [Term] id: GO:0032495 name: response to muramyl dipeptide namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add] is_a: GO:0032494 ! response to peptidoglycan [Term] id: GO:0032496 name: response to lipopolysaccharide namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464] synonym: "response to endotoxin" BROAD [GOC:sl] synonym: "response to LPS" EXACT [] is_a: GO:0002237 ! response to molecule of bacterial origin [Term] id: GO:0032497 name: detection of lipopolysaccharide namespace: biological_process def: "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, PMID:15998797] synonym: "detection of LPS" EXACT [] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0032496 ! response to lipopolysaccharide [Term] id: GO:0032498 name: detection of muramyl dipeptide namespace: biological_process def: "The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan." [GOC:rl, PMID:15998797] is_a: GO:0032495 ! response to muramyl dipeptide is_a: GO:0032499 ! detection of peptidoglycan [Term] id: GO:0032499 name: detection of peptidoglycan namespace: biological_process def: "The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0032494 ! response to peptidoglycan [Term] id: GO:0032500 name: muramyl dipeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl] is_a: GO:0042834 ! peptidoglycan binding [Term] id: GO:0032501 name: multicellular organismal process namespace: biological_process alt_id: GO:0050874 def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] subset: goslim_pir synonym: "organismal physiological process" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0032502 name: developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_pir subset: gosubset_prok synonym: "development" NARROW [] is_a: GO:0008150 ! biological_process [Term] id: GO:0032504 name: multicellular organism reproduction namespace: biological_process def: "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] is_a: GO:0000003 ! reproduction is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032505 name: reproduction of a single-celled organism namespace: biological_process def: "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0000003 ! reproduction [Term] id: GO:0032506 name: cytokinetic process namespace: biological_process def: "A cellular process that is involved in the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:isa_complete, GOC:mah] subset: gosubset_prok is_a: GO:0009987 ! cellular process relationship: part_of GO:0000910 ! cytokinesis [Term] id: GO:0032507 name: maintenance of protein location in cell namespace: biological_process def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell [Term] id: GO:0032508 name: DNA duplex unwinding namespace: biological_process def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. synonym: "DNA unwinding" EXACT [] synonym: "duplex DNA melting" EXACT [] is_a: GO:0032392 ! DNA geometric change [Term] id: GO:0032509 name: endosome transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome transport via MVB sorting pathway" EXACT [] is_a: GO:0016197 ! endosome transport [Term] id: GO:0032510 name: endosome to lysosome transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome to lysosome transport via MVB sorting pathway" EXACT [] is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway is_a: GO:0045022 ! early endosome to late endosome transport [Term] id: GO:0032511 name: late endosome to vacuole transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome to vacuole transport via MVB sorting pathway" EXACT [] is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway is_a: GO:0045324 ! late endosome to vacuole transport [Term] id: GO:0032512 name: regulation of protein phosphatase type 2B activity namespace: biological_process def: "Any process that modulates the activity of the enzyme protein phosphatase type 2B." [GOC:mah] synonym: "regulation of calcineurin activity" EXACT [] is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity [Term] id: GO:0032513 name: negative regulation of protein phosphatase type 2B activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme protein phosphatase type 2B." [GOC:mah] subset: gosubset_prok synonym: "down regulation of protein phosphatase type 2B activity" EXACT [] synonym: "down-regulation of protein phosphatase type 2B activity" EXACT [] synonym: "downregulation of protein phosphatase type 2B activity" EXACT [] synonym: "inhibition of protein phosphatase type 2B activity" NARROW [] synonym: "negative regulation of calcineurin activity" EXACT [] is_a: GO:0032512 ! regulation of protein phosphatase type 2B activity is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity [Term] id: GO:0032514 name: positive regulation of protein phosphatase type 2B activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme protein phosphatase type 2B." [GOC:mah] subset: gosubset_prok synonym: "activation of protein phosphatase type 2B activity" NARROW [] synonym: "calcineurin activation" EXACT [] synonym: "positive regulation of calcineurin activity" EXACT [] synonym: "stimulation of protein phosphatase type 2B activity" NARROW [] synonym: "up regulation of protein phosphatase type 2B activity" EXACT [] synonym: "up-regulation of protein phosphatase type 2B activity" EXACT [] synonym: "upregulation of protein phosphatase type 2B activity" EXACT [] is_a: GO:0032512 ! regulation of protein phosphatase type 2B activity is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity [Term] id: GO:0032515 name: negative regulation of phosphoprotein phosphatase activity namespace: biological_process def: "Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah] subset: gosubset_prok synonym: "down regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "down-regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "downregulation of phosphoprotein phosphatase activity" EXACT [] synonym: "inhibition of phosphoprotein phosphatase activity" NARROW [] is_a: GO:0010923 ! negative regulation of phosphatase activity is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity is_a: GO:0051004 ! regulation of lipoprotein lipase activity [Term] id: GO:0032516 name: positive regulation of phosphoprotein phosphatase activity namespace: biological_process def: "Any process that activates or increases the activity of a phosphoprotein phosphatase." [GOC:mah] subset: gosubset_prok synonym: "activation of phosphoprotein phosphatase activity" NARROW [] synonym: "stimulation of phosphoprotein phosphatase activity" NARROW [] synonym: "up regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "up-regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "upregulation of phosphoprotein phosphatase activity" EXACT [] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity is_a: GO:0051004 ! regulation of lipoprotein lipase activity [Term] id: GO:0032517 name: SOD1-calcineurin complex namespace: cellular_component def: "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1." [GOC:mah, PMID:17324120] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032518 name: amino acid-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(in) = ADP + phosphate + amino acid(out)." [GOC:mah] is_a: GO:0015424 ! amino acid-transporting ATPase activity [Term] id: GO:0032519 name: cysteine-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(in) = ADP + phosphate + cysteine(out)." [GOC:mah] synonym: "cysteine exporter" RELATED [] is_a: GO:0032518 ! amino acid-exporting ATPase activity is_a: GO:0033230 ! cysteine-transporting ATPase activity [Term] id: GO:0032520 name: amino acid-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out) = ADP + phosphate + amino acid(in)." [GOC:mah] is_a: GO:0015424 ! amino acid-transporting ATPase activity [Term] id: GO:0032521 name: D-methionine-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(in) = ADP + phosphate + D-methionine(out)." [GOC:mah] synonym: "D-methionine exporter" RELATED [] is_a: GO:0032518 ! amino acid-exporting ATPase activity is_a: GO:0033232 ! D-methionine-transporting ATPase activity [Term] id: GO:0032522 name: D-methionine-importing ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out) = ADP + phosphate + D-methionine(in)." [GOC:mah] synonym: "D-methionine importer" RELATED [] is_a: GO:0032520 ! amino acid-importing ATPase activity is_a: GO:0033232 ! D-methionine-transporting ATPase activity [Term] id: GO:0032523 name: silicon efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of silicon from the inside of the cell to the outside of the cell across a membrane." [GOC:mah, PMID:17625566] synonym: "silicon efflux transporter activity" EXACT [] is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0032524 name: nutrient export namespace: biological_process def: "OBSOLETE. The directed movement of nutrients out of a cell or organelle." [GOC:mah] comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. subset: gosubset_prok is_obsolete: true consider: GO:0006810 [Term] id: GO:0032525 name: somite rostral/caudal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary." [GOC:bf, PMID:16326386, PMID:17360776] synonym: "somite rostrocaudal axis specification" EXACT [] synonym: "somite rostrocaudal polarity" RELATED [] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0032526 name: response to retinoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl] synonym: "response to vitamin A acid" EXACT [] is_a: GO:0033189 ! response to vitamin A [Term] id: GO:0032527 name: protein exit from endoplasmic reticulum namespace: biological_process def: "The directed movement of proteins from the endoplasmic reticulum." [GOC:rb] synonym: "protein exit from ER" EXACT [] synonym: "protein export from endoplasmic reticulum" EXACT [GOC:mah] synonym: "protein export from ER" EXACT [GOC:mah] is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0032528 name: microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah] synonym: "microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030030 ! cell projection organization [Term] id: GO:0032529 name: follicle cell microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588] synonym: "follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032528 ! microvillus organization [Term] id: GO:0032530 name: regulation of microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah] synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization relationship: regulates GO:0032528 ! microvillus organization [Term] id: GO:0032531 name: regulation of follicle cell microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell." [GOC:mah] synonym: "regulation of follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization relationship: regulates GO:0032529 ! follicle cell microvillus organization [Term] id: GO:0032532 name: regulation of microvillus length namespace: biological_process def: "A process that modulates the length of a microvillus." [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization is_a: GO:0032536 ! regulation of cell projection size [Term] id: GO:0032533 name: regulation of follicle cell microvillus length namespace: biological_process def: "A process that modulates the length of a microvillus on a follicle cell." [GOC:sart, PMID:16260500] is_a: GO:0032531 ! regulation of follicle cell microvillus organization is_a: GO:0032532 ! regulation of microvillus length [Term] id: GO:0032534 name: regulation of microvillus assembly namespace: biological_process def: "A process that modulates the formation of a microvillus." [GOC:mah] synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization is_a: GO:0060491 ! regulation of cell projection assembly relationship: regulates GO:0030033 ! microvillus assembly [Term] id: GO:0032535 name: regulation of cellular component size namespace: biological_process def: "A process that modulates the size of a cellular component." [GOC:mah] subset: gosubset_prok is_a: GO:0016043 ! cellular component organization is_a: GO:0090066 ! regulation of anatomical structure size [Term] id: GO:0032536 name: regulation of cell projection size namespace: biological_process def: "A process that modulates the size of a cell projection." [GOC:mah] is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0032537 name: host-seeking behavior namespace: biological_process def: "The specific actions or reactions of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host." [GOC:mah, PMID:11931033] synonym: "host-seeking behaviour" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0032538 name: regulation of host-seeking behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] synonym: "regulation of host-seeking behaviour" EXACT [] is_a: GO:0050795 ! regulation of behavior relationship: regulates GO:0032537 ! host-seeking behavior [Term] id: GO:0032539 name: negative regulation of host-seeking behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] synonym: "down regulation of host-seeking behavior" EXACT [] synonym: "down-regulation of host-seeking behavior" EXACT [] synonym: "downregulation of host-seeking behavior" EXACT [] synonym: "inhibition of host-seeking behavior" NARROW [] synonym: "negative regulation of host-seeking behaviour" EXACT [] is_a: GO:0032538 ! regulation of host-seeking behavior is_a: GO:0048521 ! negative regulation of behavior relationship: negatively_regulates GO:0032537 ! host-seeking behavior [Term] id: GO:0032540 name: positive regulation of host-seeking behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] synonym: "activation of host-seeking behavior" NARROW [] synonym: "positive regulation of host-seeking behaviour" EXACT [] synonym: "stimulation of host-seeking behavior" NARROW [] synonym: "up regulation of host-seeking behavior" EXACT [] synonym: "up-regulation of host-seeking behavior" EXACT [] synonym: "upregulation of host-seeking behavior" EXACT [] is_a: GO:0032538 ! regulation of host-seeking behavior is_a: GO:0048520 ! positive regulation of behavior relationship: positively_regulates GO:0032537 ! host-seeking behavior [Term] id: GO:0032541 name: cortical endoplasmic reticulum namespace: cellular_component def: "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements." [GOC:se, PMID:10931860, PMID:17686782] synonym: "cortical ER" EXACT [] synonym: "peripheral endoplasmic reticulum" EXACT [] synonym: "peripheral ER" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044448 ! cell cortex part [Term] id: GO:0032542 name: sulfiredoxin activity namespace: molecular_function def: "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2] synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity" EXACT [] synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]" RELATED [EC:1.8.98.2] synonym: "Srx1" RELATED [EC:1.8.98.2] synonym: "sulphiredoxin activity" EXACT [] xref: EC:1.8.98.2 xref: MetaCyc:1.8.98.2-RXN is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0032543 name: mitochondrial translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] synonym: "mitochondrial protein anabolism" EXACT [] synonym: "mitochondrial protein biosynthesis" EXACT [] synonym: "mitochondrial protein formation" EXACT [] synonym: "mitochondrial protein synthesis" EXACT [] synonym: "mitochondrial protein translation" EXACT [] is_a: GO:0006412 ! translation is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0032544 name: plastid translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] synonym: "plastid protein anabolism" EXACT [] synonym: "plastid protein biosynthesis" EXACT [] synonym: "plastid protein formation" EXACT [] synonym: "plastid protein synthesis" EXACT [] synonym: "plastid protein translation" EXACT [] is_a: GO:0006412 ! translation is_a: GO:0009657 ! plastid organization [Term] id: GO:0032545 name: CURI complex namespace: cellular_component def: "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p andIfh1p." [PMID:17452446] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032546 name: deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose." [GOC:mah] subset: gosubset_prok is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0032547 name: purine deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose." [GOC:mah] subset: gosubset_prok is_a: GO:0001883 ! purine nucleoside binding is_a: GO:0032546 ! deoxyribonucleoside binding [Term] id: GO:0032548 name: pyrimidine deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose." [GOC:mah] subset: gosubset_prok is_a: GO:0001884 ! pyrimidine nucleoside binding is_a: GO:0032546 ! deoxyribonucleoside binding [Term] id: GO:0032549 name: ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah] subset: gosubset_prok is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0032550 name: purine ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah] subset: gosubset_prok is_a: GO:0001883 ! purine nucleoside binding is_a: GO:0032549 ! ribonucleoside binding [Term] id: GO:0032551 name: pyrimidine ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose." [GOC:mah] subset: gosubset_prok is_a: GO:0001884 ! pyrimidine nucleoside binding is_a: GO:0032549 ! ribonucleoside binding [Term] id: GO:0032552 name: deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0032553 name: ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0032554 name: purine deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0017076 ! purine nucleotide binding is_a: GO:0032552 ! deoxyribonucleotide binding [Term] id: GO:0032555 name: purine ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0017076 ! purine nucleotide binding is_a: GO:0032553 ! ribonucleotide binding [Term] id: GO:0032556 name: pyrimidine deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0019103 ! pyrimidine nucleotide binding is_a: GO:0032552 ! deoxyribonucleotide binding [Term] id: GO:0032557 name: pyrimidine ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0019103 ! pyrimidine nucleotide binding is_a: GO:0032553 ! ribonucleotide binding [Term] id: GO:0032558 name: adenyl deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0032554 ! purine deoxyribonucleotide binding [Term] id: GO:0032559 name: adenyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0032555 ! purine ribonucleotide binding [Term] id: GO:0032560 name: guanyl deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0019001 ! guanyl nucleotide binding is_a: GO:0032554 ! purine deoxyribonucleotide binding [Term] id: GO:0032561 name: guanyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0019001 ! guanyl nucleotide binding is_a: GO:0032555 ! purine ribonucleotide binding [Term] id: GO:0032562 name: dAMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dAMP, deoxyadenosine monophosphate." [GOC:mah] is_a: GO:0032558 ! adenyl deoxyribonucleotide binding [Term] id: GO:0032563 name: dADP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dADP, deoxyadenosine diphosphate." [GOC:mah] is_a: GO:0032558 ! adenyl deoxyribonucleotide binding [Term] id: GO:0032564 name: dATP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate." [GOC:mah] is_a: GO:0032558 ! adenyl deoxyribonucleotide binding [Term] id: GO:0032565 name: dGMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dGMP, deoxyguanosine monophosphate." [GOC:mah] is_a: GO:0032560 ! guanyl deoxyribonucleotide binding [Term] id: GO:0032566 name: dGDP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dGDP, deoxyguanosine diphosphate." [GOC:mah] is_a: GO:0032560 ! guanyl deoxyribonucleotide binding [Term] id: GO:0032567 name: dGTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dGTP, deoxyguanosine triphosphate." [GOC:mah] is_a: GO:0032560 ! guanyl deoxyribonucleotide binding [Term] id: GO:0032570 name: response to progesterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl] is_a: GO:0048545 ! response to steroid hormone stimulus [Term] id: GO:0032571 name: response to vitamin K namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:sl] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0032572 name: response to menaquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:sl] synonym: "response to menatetrenone" EXACT [] synonym: "response to vitamin K2" EXACT [] is_a: GO:0032571 ! response to vitamin K [Term] id: GO:0032573 name: response to phylloquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl] synonym: "response to vitamin K1" EXACT [] is_a: GO:0032571 ! response to vitamin K [Term] id: GO:0032574 name: 5'-3' RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp] synonym: "5' to 3' RNA helicase activity" EXACT [] is_a: GO:0003724 ! RNA helicase activity [Term] id: GO:0032575 name: ATP-dependent 5'-3' RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp] synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT [] is_a: GO:0004004 ! ATP-dependent RNA helicase activity is_a: GO:0032574 ! 5'-3' RNA helicase activity [Term] id: GO:0032576 name: O-linoleoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule." [GOC:cb] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0032577 name: phosphatidylcholine:cardiolipin O-linoleoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah] synonym: "phosphatidylcholine:cardiolipin linoleoyltransferase" EXACT [] is_a: GO:0032576 ! O-linoleoyltransferase activity [Term] id: GO:0032578 name: aleurone grain membrane namespace: cellular_component def: "The lipid bilayer surrounding an aleurone grain." [GOC:ecd] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0033095 ! aleurone grain [Term] id: GO:0032579 name: apical lamina of hyaline layer namespace: cellular_component def: "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms." [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331] is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0033166 ! hyaline layer [Term] id: GO:0032580 name: Golgi cisterna membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah] synonym: "Golgi stack membrane" EXACT [] is_a: GO:0000139 ! Golgi membrane relationship: part_of GO:0031985 ! Golgi cisterna [Term] id: GO:0032581 name: ER-dependent peroxisome organization namespace: biological_process def: "A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum." [GOC:mah, PMID:16717127, PMID:17646399] synonym: "endoplasmic reticulum-dependent peroxisome organization" EXACT [GOC:mah] synonym: "ER-dependent peroxisome biogenesis" RELATED [GOC:mah] synonym: "ER-dependent peroxisome organisation" EXACT [GOC:mah] is_a: GO:0007031 ! peroxisome organization [Term] id: GO:0032584 name: growth cone membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a growth cone." [GOC:mah] is_a: GO:0044459 ! plasma membrane part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0030426 ! growth cone [Term] id: GO:0032585 name: multivesicular body membrane namespace: cellular_component def: "The lipid bilayer surrounding a multivesicular body." [GOC:mah] synonym: "multivesicular endosome membrane" EXACT [] synonym: "MVB membrane" EXACT [] synonym: "MVE membrane" EXACT [] is_a: GO:0031902 ! late endosome membrane relationship: part_of GO:0005771 ! multivesicular body [Term] id: GO:0032586 name: protein storage vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a protein storage vacuole." [GOC:mah] is_a: GO:0009705 ! plant-type vacuole membrane [Term] id: GO:0032587 name: ruffle membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a ruffle." [GOC:mah] synonym: "membrane ruffle" RELATED [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane relationship: part_of GO:0001726 ! ruffle [Term] id: GO:0032588 name: trans-Golgi network membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah] synonym: "Golgi trans face membrane" RELATED [] synonym: "trans Golgi network membrane" EXACT [] is_a: GO:0000139 ! Golgi membrane relationship: part_of GO:0005802 ! trans-Golgi network [Term] id: GO:0032589 name: neuron projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane relationship: part_of GO:0043005 ! neuron projection [Term] id: GO:0032590 name: dendrite membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah] is_a: GO:0032589 ! neuron projection membrane [Term] id: GO:0032591 name: dendritic spine membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendritic spine." [GOC:mah] is_a: GO:0032589 ! neuron projection membrane relationship: part_of GO:0043197 ! dendritic spine [Term] id: GO:0032592 name: integral to mitochondrial membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of a mitochondrial membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031301 ! integral to organelle membrane is_a: GO:0044455 ! mitochondrial membrane part [Term] id: GO:0032593 name: insulin-responsive compartment namespace: cellular_component def: "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2." [PMID:17644329] synonym: "GLUT4 storage compartment" EXACT [] synonym: "GSC" RELATED [] synonym: "IRC" RELATED [] is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0032594 name: protein transport within lipid bilayer namespace: biological_process def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] synonym: "protein translocation within membrane" EXACT [] synonym: "receptor translocation within membrane" NARROW [] synonym: "receptor transport within lipid bilayer" NARROW [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0032595 name: B cell receptor transport within lipid bilayer namespace: biological_process def: "The directed movement of a B cell receptor within a lipid bilayer." [GOC:mah] synonym: "B cell receptor translocation within membrane" EXACT [] synonym: "BCR translocation within membrane" EXACT [] synonym: "BCR transport within lipid bilayer" EXACT [] is_a: GO:0032594 ! protein transport within lipid bilayer [Term] id: GO:0032596 name: protein transport into membrane raft namespace: biological_process def: "The directed movement of a protein into a membrane raft." [GOC:mah] synonym: "protein translocation into membrane raft" EXACT [] synonym: "protein transport into lipid raft" EXACT [] synonym: "receptor translocation into membrane raft" NARROW [] synonym: "receptor transport into membrane raft" NARROW [] is_a: GO:0032594 ! protein transport within lipid bilayer [Term] id: GO:0032597 name: B cell receptor transport into membrane raft namespace: biological_process def: "The directed movement of a B cell receptor into a membrane raft." [GOC:mah] synonym: "B cell receptor translocation into membrane raft" EXACT [] synonym: "B cell receptor transport into lipid raft" EXACT [] synonym: "BCR translocation into membrane raft" EXACT [] synonym: "BCR transport into membrane raft" EXACT [] is_a: GO:0032595 ! B cell receptor transport within lipid bilayer is_a: GO:0032596 ! protein transport into membrane raft [Term] id: GO:0032598 name: B cell receptor transport into immunological synapse namespace: biological_process def: "The directed movement of a B cell receptor into an immunological synapse." [GOC:mah] synonym: "B cell receptor translocation into immunological synapse" EXACT [] synonym: "BCR translocation into immunological synapse" EXACT [] synonym: "BCR transport into immunological synapse" EXACT [] is_a: GO:0032597 ! B cell receptor transport into membrane raft [Term] id: GO:0032599 name: protein transport out of membrane raft namespace: biological_process def: "The directed movement of a protein out of a membrane raft." [GOC:mah] synonym: "protein translocation out of membrane raft" EXACT [] synonym: "protein transport out of lipid raft" EXACT [] synonym: "receptor translocation out of membrane raft" NARROW [] synonym: "receptor transport out of membrane raft" NARROW [] is_a: GO:0032594 ! protein transport within lipid bilayer [Term] id: GO:0032600 name: chemokine receptor transport out of membrane raft namespace: biological_process def: "The directed movement of a chemokine receptor out of a membrane raft." [GOC:mah] synonym: "chemokine receptor translocation out of membrane raft" EXACT [] synonym: "chemokine receptor transport out of lipid raft" EXACT [] is_a: GO:0032599 ! protein transport out of membrane raft is_a: GO:0033606 ! chemokine receptor transport within lipid bilayer [Term] id: GO:0032601 name: connective tissue growth factor production namespace: biological_process def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "CCN2 production" EXACT [] synonym: "CTGF production" EXACT [] synonym: "Fisp12 production" EXACT [] synonym: "Hcs24 production" EXACT [] synonym: "hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "IGFBP8 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032602 name: chemokine production namespace: biological_process def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032603 name: fractalkine production namespace: biological_process def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0032602 ! chemokine production [Term] id: GO:0032604 name: granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "granulocyte macrophage colony stimulating factor production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032605 name: hepatocyte growth factor production namespace: biological_process def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032606 name: type I interferon production namespace: biological_process def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon type I production" EXACT [] synonym: "type I IFN production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032607 name: interferon-alpha production namespace: biological_process def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IFN-alpha production" EXACT [GOC:mah] synonym: "IFNA production" EXACT [GOC:mah] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0032608 name: interferon-beta production namespace: biological_process def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IFN-beta production" EXACT [] synonym: "IFNB production" EXACT [GOC:mah] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0032609 name: interferon-gamma production namespace: biological_process def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "IFNG production" EXACT [GOC:mah] synonym: "type II IFN production" EXACT [GOC:mah] synonym: "type II interferon production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032610 name: interleukin-1 alpha production namespace: biological_process def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 alpha production" EXACT [] is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032611 name: interleukin-1 beta production namespace: biological_process def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 beta production" EXACT [] is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032612 name: interleukin-1 production namespace: biological_process def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032613 name: interleukin-10 production namespace: biological_process def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-10 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032614 name: interleukin-11 production namespace: biological_process def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-11 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032615 name: interleukin-12 production namespace: biological_process def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-12 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032616 name: interleukin-13 production namespace: biological_process def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-13 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032617 name: interleukin-14 production namespace: biological_process def: "The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-14 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032618 name: interleukin-15 production namespace: biological_process def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-15 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032619 name: interleukin-16 production namespace: biological_process def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-16 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032620 name: interleukin-17 production namespace: biological_process def: "The appearance of interleukin-17 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-17 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032621 name: interleukin-18 production namespace: biological_process def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-18 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032622 name: interleukin-19 production namespace: biological_process def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-19 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032623 name: interleukin-2 production namespace: biological_process def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-2 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032624 name: interleukin-20 production namespace: biological_process def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-20 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032625 name: interleukin-21 production namespace: biological_process def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-21 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032626 name: interleukin-22 production namespace: biological_process def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-22 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032627 name: interleukin-23 production namespace: biological_process def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-23 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032628 name: interleukin-24 production namespace: biological_process def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-24 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032629 name: interleukin-25 production namespace: biological_process def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-25 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032630 name: interleukin-26 production namespace: biological_process def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-26 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032631 name: interleukin-27 production namespace: biological_process def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-27 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032632 name: interleukin-3 production namespace: biological_process def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-3 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032633 name: interleukin-4 production namespace: biological_process def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-4 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032634 name: interleukin-5 production namespace: biological_process def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-5 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032635 name: interleukin-6 production namespace: biological_process def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-6 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032636 name: interleukin-7 production namespace: biological_process def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-7 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032637 name: interleukin-8 production namespace: biological_process def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-8 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032638 name: interleukin-9 production namespace: biological_process def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-9 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032639 name: TRAIL production namespace: biological_process def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032640 name: tumor necrosis factor production namespace: biological_process def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "TNF production" EXACT [] synonym: "TNF-alpha production" EXACT [] synonym: "tumor necrosis factor-alpha production" EXACT [] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032641 name: lymphotoxin A production namespace: biological_process def: "The appearance of lymphotoxin A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "LTA production" EXACT [] synonym: "lymphotoxin-alpha production" EXACT [] synonym: "TNF-beta production" EXACT [] synonym: "tumor necrosis factor-beta production" EXACT [] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032642 name: regulation of chemokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of chemokine production." [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032602 ! chemokine production [Term] id: GO:0032643 name: regulation of connective tissue growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "regulation of CCN2 production" EXACT [] synonym: "regulation of CTGF production" EXACT [] synonym: "regulation of Fisp12 production" EXACT [] synonym: "regulation of Hcs24 production" EXACT [] synonym: "regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "regulation of IGFBP8 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032601 ! connective tissue growth factor production [Term] id: GO:0032644 name: regulation of fractalkine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0032603 ! fractalkine production [Term] id: GO:0032645 name: regulation of granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] synonym: "regulation of granulocyte macrophage colony stimulating factor production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0032646 name: regulation of hepatocyte growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0032647 name: regulation of interferon-alpha production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah] is_a: GO:0032479 ! regulation of type I interferon production relationship: regulates GO:0032607 ! interferon-alpha production [Term] id: GO:0032648 name: regulation of interferon-beta production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah] synonym: "regulation of IFN-beta production" EXACT [] is_a: GO:0032479 ! regulation of type I interferon production relationship: regulates GO:0032608 ! interferon-beta production [Term] id: GO:0032649 name: regulation of interferon-gamma production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "regulation of type II interferon production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032609 ! interferon-gamma production [Term] id: GO:0032650 name: regulation of interleukin-1 alpha production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "regulation of IL-1 alpha production" EXACT [] is_a: GO:0032652 ! regulation of interleukin-1 production relationship: regulates GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0032651 name: regulation of interleukin-1 beta production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "regulation of IL-1 beta production" EXACT [] is_a: GO:0032652 ! regulation of interleukin-1 production relationship: regulates GO:0032611 ! interleukin-1 beta production [Term] id: GO:0032652 name: regulation of interleukin-1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "regulation of IL-1 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032612 ! interleukin-1 production [Term] id: GO:0032653 name: regulation of interleukin-10 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "regulation of IL-10 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032613 ! interleukin-10 production [Term] id: GO:0032654 name: regulation of interleukin-11 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "regulation of IL-11 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032614 ! interleukin-11 production [Term] id: GO:0032655 name: regulation of interleukin-12 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "regulation of IL-12 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032615 ! interleukin-12 production [Term] id: GO:0032656 name: regulation of interleukin-13 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "regulation of IL-13 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032616 ! interleukin-13 production [Term] id: GO:0032657 name: regulation of interleukin-14 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "regulation of IL-14 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032617 ! interleukin-14 production [Term] id: GO:0032658 name: regulation of interleukin-15 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "regulation of IL-15 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032618 ! interleukin-15 production [Term] id: GO:0032659 name: regulation of interleukin-16 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "regulation of IL-16 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032619 ! interleukin-16 production [Term] id: GO:0032660 name: regulation of interleukin-17 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-17 production." [GOC:mah] synonym: "regulation of IL-17 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032620 ! interleukin-17 production [Term] id: GO:0032661 name: regulation of interleukin-18 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "regulation of IL-18 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032621 ! interleukin-18 production [Term] id: GO:0032662 name: regulation of interleukin-19 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "regulation of IL-19 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032622 ! interleukin-19 production [Term] id: GO:0032663 name: regulation of interleukin-2 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "regulation of IL-2 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032623 ! interleukin-2 production [Term] id: GO:0032664 name: regulation of interleukin-20 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "regulation of IL-20 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032624 ! interleukin-20 production [Term] id: GO:0032665 name: regulation of interleukin-21 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "regulation of IL-21 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032625 ! interleukin-21 production [Term] id: GO:0032666 name: regulation of interleukin-22 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "regulation of IL-22 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032626 ! interleukin-22 production [Term] id: GO:0032667 name: regulation of interleukin-23 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "regulation of IL-23 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032627 ! interleukin-23 production [Term] id: GO:0032668 name: regulation of interleukin-24 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "regulation of IL-24 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032628 ! interleukin-24 production [Term] id: GO:0032669 name: regulation of interleukin-25 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "regulation of IL-25 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032629 ! interleukin-25 production [Term] id: GO:0032670 name: regulation of interleukin-26 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "regulation of IL-26 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032630 ! interleukin-26 production [Term] id: GO:0032671 name: regulation of interleukin-27 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "regulation of IL-27 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032631 ! interleukin-27 production [Term] id: GO:0032672 name: regulation of interleukin-3 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "regulation of IL-3 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032632 ! interleukin-3 production [Term] id: GO:0032673 name: regulation of interleukin-4 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "regulation of IL-4 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032633 ! interleukin-4 production [Term] id: GO:0032674 name: regulation of interleukin-5 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "regulation of IL-5 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032634 ! interleukin-5 production [Term] id: GO:0032675 name: regulation of interleukin-6 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "regulation of IL-6 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032635 ! interleukin-6 production [Term] id: GO:0032676 name: regulation of interleukin-7 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "regulation of IL-7 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032636 ! interleukin-7 production [Term] id: GO:0032677 name: regulation of interleukin-8 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "regulation of IL-8 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032637 ! interleukin-8 production [Term] id: GO:0032678 name: regulation of interleukin-9 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "regulation of IL-9 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032638 ! interleukin-9 production [Term] id: GO:0032679 name: regulation of TRAIL production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of TRAIL production." [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032639 ! TRAIL production [Term] id: GO:0032680 name: regulation of tumor necrosis factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "regulation of TNF production" EXACT [] synonym: "regulation of TNF-alpha production" EXACT [] synonym: "regulation of tumor necrosis factor-alpha production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032640 ! tumor necrosis factor production [Term] id: GO:0032681 name: regulation of lymphotoxin A production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] synonym: "regulation of LTA production" EXACT [] synonym: "regulation of lymphotoxin-alpha production" EXACT [] synonym: "regulation of TNF-beta production" EXACT [] synonym: "regulation of tumor necrosis factor-beta production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032641 ! lymphotoxin A production [Term] id: GO:0032682 name: negative regulation of chemokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." [GOC:mah] synonym: "down regulation of chemokine production" EXACT [] synonym: "down-regulation of chemokine production" EXACT [] synonym: "downregulation of chemokine production" EXACT [] synonym: "inhibition of chemokine production" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032642 ! regulation of chemokine production relationship: negatively_regulates GO:0032602 ! chemokine production [Term] id: GO:0032683 name: negative regulation of connective tissue growth factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "down regulation of connective tissue growth factor production" EXACT [] synonym: "down-regulation of connective tissue growth factor production" EXACT [] synonym: "downregulation of connective tissue growth factor production" EXACT [] synonym: "inhibition of connective tissue growth factor production" NARROW [] synonym: "negative regulation of CCN2 production" EXACT [] synonym: "negative regulation of CTGF production" EXACT [] synonym: "negative regulation of Fisp12 production" EXACT [] synonym: "negative regulation of Hcs24 production" EXACT [] synonym: "negative regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "negative regulation of IGFBP8 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032643 ! regulation of connective tissue growth factor production relationship: negatively_regulates GO:0032601 ! connective tissue growth factor production [Term] id: GO:0032684 name: negative regulation of fractalkine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah] synonym: "down regulation of fractalkine production" EXACT [] synonym: "down-regulation of fractalkine production" EXACT [] synonym: "downregulation of fractalkine production" EXACT [] synonym: "inhibition of fractalkine production" NARROW [] is_a: GO:0032644 ! regulation of fractalkine production is_a: GO:0032682 ! negative regulation of chemokine production relationship: negatively_regulates GO:0032603 ! fractalkine production [Term] id: GO:0032685 name: negative regulation of granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] synonym: "down regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "down-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "downregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "inhibition of granulocyte macrophage colony-stimulating factor production" NARROW [] synonym: "negative regulation of granulocyte macrophage colony stimulating factor production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production relationship: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0032686 name: negative regulation of hepatocyte growth factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] synonym: "down regulation of hepatocyte growth factor production" EXACT [] synonym: "down-regulation of hepatocyte growth factor production" EXACT [] synonym: "downregulation of hepatocyte growth factor production" EXACT [] synonym: "inhibition of hepatocyte growth factor production" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032646 ! regulation of hepatocyte growth factor production relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0032687 name: negative regulation of interferon-alpha production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah] synonym: "down regulation of interferon-alpha production" EXACT [] synonym: "down-regulation of interferon-alpha production" EXACT [] synonym: "downregulation of interferon-alpha production" EXACT [] synonym: "inhibition of interferon-alpha production" NARROW [] is_a: GO:0032480 ! negative regulation of type I interferon production is_a: GO:0032647 ! regulation of interferon-alpha production relationship: negatively_regulates GO:0032607 ! interferon-alpha production [Term] id: GO:0032688 name: negative regulation of interferon-beta production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah] synonym: "down regulation of interferon-beta production" EXACT [] synonym: "down-regulation of interferon-beta production" EXACT [] synonym: "downregulation of interferon-beta production" EXACT [] synonym: "inhibition of interferon-beta production" NARROW [] synonym: "negative regulation of IFN-beta production" EXACT [] is_a: GO:0032480 ! negative regulation of type I interferon production is_a: GO:0032648 ! regulation of interferon-beta production relationship: negatively_regulates GO:0032608 ! interferon-beta production [Term] id: GO:0032689 name: negative regulation of interferon-gamma production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "down regulation of interferon-gamma production" EXACT [] synonym: "down-regulation of interferon-gamma production" EXACT [] synonym: "downregulation of interferon-gamma production" EXACT [] synonym: "inhibition of interferon-gamma production" NARROW [] synonym: "negative regulation of type II interferon production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032649 ! regulation of interferon-gamma production relationship: negatively_regulates GO:0032609 ! interferon-gamma production [Term] id: GO:0032690 name: negative regulation of interleukin-1 alpha production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "down regulation of interleukin-1 alpha production" EXACT [] synonym: "down-regulation of interleukin-1 alpha production" EXACT [] synonym: "downregulation of interleukin-1 alpha production" EXACT [] synonym: "inhibition of interleukin-1 alpha production" NARROW [] synonym: "negative regulation of IL-1 alpha production" EXACT [] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0032692 ! negative regulation of interleukin-1 production relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0032691 name: negative regulation of interleukin-1 beta production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "down regulation of interleukin-1 beta production" EXACT [] synonym: "down-regulation of interleukin-1 beta production" EXACT [] synonym: "downregulation of interleukin-1 beta production" EXACT [] synonym: "inhibition of interleukin-1 beta production" NARROW [] synonym: "negative regulation of IL-1 beta production" EXACT [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0032692 ! negative regulation of interleukin-1 production relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production [Term] id: GO:0032692 name: negative regulation of interleukin-1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "down regulation of interleukin-1 production" EXACT [] synonym: "down-regulation of interleukin-1 production" EXACT [] synonym: "downregulation of interleukin-1 production" EXACT [] synonym: "inhibition of interleukin-1 production" NARROW [] synonym: "negative regulation of IL-1 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032652 ! regulation of interleukin-1 production relationship: negatively_regulates GO:0032612 ! interleukin-1 production [Term] id: GO:0032693 name: negative regulation of interleukin-10 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "down regulation of interleukin-10 production" EXACT [] synonym: "down-regulation of interleukin-10 production" EXACT [] synonym: "downregulation of interleukin-10 production" EXACT [] synonym: "inhibition of interleukin-10 production" NARROW [] synonym: "negative regulation of IL-10 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032653 ! regulation of interleukin-10 production relationship: negatively_regulates GO:0032613 ! interleukin-10 production [Term] id: GO:0032694 name: negative regulation of interleukin-11 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "down regulation of interleukin-11 production" EXACT [] synonym: "down-regulation of interleukin-11 production" EXACT [] synonym: "downregulation of interleukin-11 production" EXACT [] synonym: "inhibition of interleukin-11 production" NARROW [] synonym: "negative regulation of IL-11 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032654 ! regulation of interleukin-11 production relationship: negatively_regulates GO:0032614 ! interleukin-11 production [Term] id: GO:0032695 name: negative regulation of interleukin-12 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "down regulation of interleukin-12 production" EXACT [] synonym: "down-regulation of interleukin-12 production" EXACT [] synonym: "downregulation of interleukin-12 production" EXACT [] synonym: "inhibition of interleukin-12 production" NARROW [] synonym: "negative regulation of IL-12 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032655 ! regulation of interleukin-12 production relationship: negatively_regulates GO:0032615 ! interleukin-12 production [Term] id: GO:0032696 name: negative regulation of interleukin-13 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "down regulation of interleukin-13 production" EXACT [] synonym: "down-regulation of interleukin-13 production" EXACT [] synonym: "downregulation of interleukin-13 production" EXACT [] synonym: "inhibition of interleukin-13 production" NARROW [] synonym: "negative regulation of IL-13 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032656 ! regulation of interleukin-13 production relationship: negatively_regulates GO:0032616 ! interleukin-13 production [Term] id: GO:0032697 name: negative regulation of interleukin-14 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "down regulation of interleukin-14 production" EXACT [] synonym: "down-regulation of interleukin-14 production" EXACT [] synonym: "downregulation of interleukin-14 production" EXACT [] synonym: "inhibition of interleukin-14 production" NARROW [] synonym: "negative regulation of IL-14 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032657 ! regulation of interleukin-14 production relationship: negatively_regulates GO:0032617 ! interleukin-14 production [Term] id: GO:0032698 name: negative regulation of interleukin-15 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "down regulation of interleukin-15 production" EXACT [] synonym: "down-regulation of interleukin-15 production" EXACT [] synonym: "downregulation of interleukin-15 production" EXACT [] synonym: "inhibition of interleukin-15 production" NARROW [] synonym: "negative regulation of IL-15 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032658 ! regulation of interleukin-15 production relationship: negatively_regulates GO:0032618 ! interleukin-15 production [Term] id: GO:0032699 name: negative regulation of interleukin-16 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "down regulation of interleukin-16 production" EXACT [] synonym: "down-regulation of interleukin-16 production" EXACT [] synonym: "downregulation of interleukin-16 production" EXACT [] synonym: "inhibition of interleukin-16 production" NARROW [] synonym: "negative regulation of IL-16 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032659 ! regulation of interleukin-16 production relationship: negatively_regulates GO:0032619 ! interleukin-16 production [Term] id: GO:0032700 name: negative regulation of interleukin-17 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-17 production." [GOC:mah] synonym: "down regulation of interleukin-17 production" EXACT [] synonym: "down-regulation of interleukin-17 production" EXACT [] synonym: "downregulation of interleukin-17 production" EXACT [] synonym: "inhibition of interleukin-17 production" NARROW [] synonym: "negative regulation of IL-17 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032660 ! regulation of interleukin-17 production relationship: negatively_regulates GO:0032620 ! interleukin-17 production [Term] id: GO:0032701 name: negative regulation of interleukin-18 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "down regulation of interleukin-18 production" EXACT [] synonym: "down-regulation of interleukin-18 production" EXACT [] synonym: "downregulation of interleukin-18 production" EXACT [] synonym: "inhibition of interleukin-18 production" NARROW [] synonym: "negative regulation of IL-18 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032661 ! regulation of interleukin-18 production relationship: negatively_regulates GO:0032621 ! interleukin-18 production [Term] id: GO:0032702 name: negative regulation of interleukin-19 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "down regulation of interleukin-19 production" EXACT [] synonym: "down-regulation of interleukin-19 production" EXACT [] synonym: "downregulation of interleukin-19 production" EXACT [] synonym: "inhibition of interleukin-19 production" NARROW [] synonym: "negative regulation of IL-19 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032662 ! regulation of interleukin-19 production relationship: negatively_regulates GO:0032622 ! interleukin-19 production [Term] id: GO:0032703 name: negative regulation of interleukin-2 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "down regulation of interleukin-2 production" EXACT [] synonym: "down-regulation of interleukin-2 production" EXACT [] synonym: "downregulation of interleukin-2 production" EXACT [] synonym: "inhibition of interleukin-2 production" NARROW [] synonym: "negative regulation of IL-2 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032663 ! regulation of interleukin-2 production relationship: negatively_regulates GO:0032623 ! interleukin-2 production [Term] id: GO:0032704 name: negative regulation of interleukin-20 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "down regulation of interleukin-20 production" EXACT [] synonym: "down-regulation of interleukin-20 production" EXACT [] synonym: "downregulation of interleukin-20 production" EXACT [] synonym: "inhibition of interleukin-20 production" NARROW [] synonym: "negative regulation of IL-20 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032664 ! regulation of interleukin-20 production relationship: negatively_regulates GO:0032624 ! interleukin-20 production [Term] id: GO:0032705 name: negative regulation of interleukin-21 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "down regulation of interleukin-21 production" EXACT [] synonym: "down-regulation of interleukin-21 production" EXACT [] synonym: "downregulation of interleukin-21 production" EXACT [] synonym: "inhibition of interleukin-21 production" NARROW [] synonym: "negative regulation of IL-21 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032665 ! regulation of interleukin-21 production relationship: negatively_regulates GO:0032625 ! interleukin-21 production [Term] id: GO:0032706 name: negative regulation of interleukin-22 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "down regulation of interleukin-22 production" EXACT [] synonym: "down-regulation of interleukin-22 production" EXACT [] synonym: "downregulation of interleukin-22 production" EXACT [] synonym: "inhibition of interleukin-22 production" NARROW [] synonym: "negative regulation of IL-22 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032666 ! regulation of interleukin-22 production relationship: negatively_regulates GO:0032626 ! interleukin-22 production [Term] id: GO:0032707 name: negative regulation of interleukin-23 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "down regulation of interleukin-23 production" EXACT [] synonym: "down-regulation of interleukin-23 production" EXACT [] synonym: "downregulation of interleukin-23 production" EXACT [] synonym: "inhibition of interleukin-23 production" NARROW [] synonym: "negative regulation of IL-23 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032667 ! regulation of interleukin-23 production relationship: negatively_regulates GO:0032627 ! interleukin-23 production [Term] id: GO:0032708 name: negative regulation of interleukin-24 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "down regulation of interleukin-24 production" EXACT [] synonym: "down-regulation of interleukin-24 production" EXACT [] synonym: "downregulation of interleukin-24 production" EXACT [] synonym: "inhibition of interleukin-24 production" NARROW [] synonym: "negative regulation of IL-24 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032668 ! regulation of interleukin-24 production relationship: negatively_regulates GO:0032628 ! interleukin-24 production [Term] id: GO:0032709 name: negative regulation of interleukin-25 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "down regulation of interleukin-25 production" EXACT [] synonym: "down-regulation of interleukin-25 production" EXACT [] synonym: "downregulation of interleukin-25 production" EXACT [] synonym: "inhibition of interleukin-25 production" NARROW [] synonym: "negative regulation of IL-25 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032669 ! regulation of interleukin-25 production relationship: negatively_regulates GO:0032629 ! interleukin-25 production [Term] id: GO:0032710 name: negative regulation of interleukin-26 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "down regulation of interleukin-26 production" EXACT [] synonym: "down-regulation of interleukin-26 production" EXACT [] synonym: "downregulation of interleukin-26 production" EXACT [] synonym: "inhibition of interleukin-26 production" NARROW [] synonym: "negative regulation of IL-26 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032670 ! regulation of interleukin-26 production relationship: negatively_regulates GO:0032630 ! interleukin-26 production [Term] id: GO:0032711 name: negative regulation of interleukin-27 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "down regulation of interleukin-27 production" EXACT [] synonym: "down-regulation of interleukin-27 production" EXACT [] synonym: "downregulation of interleukin-27 production" EXACT [] synonym: "inhibition of interleukin-27 production" NARROW [] synonym: "negative regulation of IL-27 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032671 ! regulation of interleukin-27 production relationship: negatively_regulates GO:0032631 ! interleukin-27 production [Term] id: GO:0032712 name: negative regulation of interleukin-3 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "down regulation of interleukin-3 production" EXACT [] synonym: "down-regulation of interleukin-3 production" EXACT [] synonym: "downregulation of interleukin-3 production" EXACT [] synonym: "inhibition of interleukin-3 production" NARROW [] synonym: "negative regulation of IL-3 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032672 ! regulation of interleukin-3 production relationship: negatively_regulates GO:0032632 ! interleukin-3 production [Term] id: GO:0032713 name: negative regulation of interleukin-4 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "down regulation of interleukin-4 production" EXACT [] synonym: "down-regulation of interleukin-4 production" EXACT [] synonym: "downregulation of interleukin-4 production" EXACT [] synonym: "inhibition of interleukin-4 production" NARROW [] synonym: "negative regulation of IL-4 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032673 ! regulation of interleukin-4 production relationship: negatively_regulates GO:0032633 ! interleukin-4 production [Term] id: GO:0032714 name: negative regulation of interleukin-5 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "down regulation of interleukin-5 production" EXACT [] synonym: "down-regulation of interleukin-5 production" EXACT [] synonym: "downregulation of interleukin-5 production" EXACT [] synonym: "inhibition of interleukin-5 production" NARROW [] synonym: "negative regulation of IL-5 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032674 ! regulation of interleukin-5 production relationship: negatively_regulates GO:0032634 ! interleukin-5 production [Term] id: GO:0032715 name: negative regulation of interleukin-6 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "down regulation of interleukin-6 production" EXACT [] synonym: "down-regulation of interleukin-6 production" EXACT [] synonym: "downregulation of interleukin-6 production" EXACT [] synonym: "inhibition of interleukin-6 production" NARROW [] synonym: "negative regulation of IL-6 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032675 ! regulation of interleukin-6 production relationship: negatively_regulates GO:0032635 ! interleukin-6 production [Term] id: GO:0032716 name: negative regulation of interleukin-7 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "down regulation of interleukin-7 production" EXACT [] synonym: "down-regulation of interleukin-7 production" EXACT [] synonym: "downregulation of interleukin-7 production" EXACT [] synonym: "inhibition of interleukin-7 production" NARROW [] synonym: "negative regulation of IL-7 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032676 ! regulation of interleukin-7 production relationship: negatively_regulates GO:0032636 ! interleukin-7 production [Term] id: GO:0032717 name: negative regulation of interleukin-8 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "down regulation of interleukin-8 production" EXACT [] synonym: "down-regulation of interleukin-8 production" EXACT [] synonym: "downregulation of interleukin-8 production" EXACT [] synonym: "inhibition of interleukin-8 production" NARROW [] synonym: "negative regulation of IL-8 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032677 ! regulation of interleukin-8 production relationship: negatively_regulates GO:0032637 ! interleukin-8 production [Term] id: GO:0032718 name: negative regulation of interleukin-9 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "down regulation of interleukin-9 production" EXACT [] synonym: "down-regulation of interleukin-9 production" EXACT [] synonym: "downregulation of interleukin-9 production" EXACT [] synonym: "inhibition of interleukin-9 production" NARROW [] synonym: "negative regulation of IL-9 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032678 ! regulation of interleukin-9 production relationship: negatively_regulates GO:0032638 ! interleukin-9 production [Term] id: GO:0032719 name: negative regulation of TRAIL production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production." [GOC:mah] synonym: "down regulation of TRAIL production" EXACT [] synonym: "down-regulation of TRAIL production" EXACT [] synonym: "downregulation of TRAIL production" EXACT [] synonym: "inhibition of TRAIL production" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032679 ! regulation of TRAIL production relationship: negatively_regulates GO:0032639 ! TRAIL production [Term] id: GO:0032720 name: negative regulation of tumor necrosis factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "down regulation of tumor necrosis factor production" EXACT [] synonym: "down-regulation of tumor necrosis factor production" EXACT [] synonym: "downregulation of tumor necrosis factor production" EXACT [] synonym: "inhibition of tumor necrosis factor production" NARROW [] synonym: "negative regulation TNF production" EXACT [] synonym: "negative regulation TNF-alpha production" EXACT [] synonym: "negative regulation tumor necrosis factor-alpha production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032680 ! regulation of tumor necrosis factor production relationship: negatively_regulates GO:0032640 ! tumor necrosis factor production [Term] id: GO:0032721 name: negative regulation of lymphotoxin A production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] synonym: "down regulation of lymphotoxin A production" EXACT [] synonym: "down-regulation of lymphotoxin A production" EXACT [] synonym: "downregulation of lymphotoxin A production" EXACT [] synonym: "inhibition of lymphotoxin A production" NARROW [] synonym: "negative regulation of LTA production" EXACT [] synonym: "negative regulation of lymphotoxin-alpha production" EXACT [] synonym: "negative regulation of TNF-beta production" EXACT [] synonym: "negative regulation of tumor necrosis factor-beta production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032681 ! regulation of lymphotoxin A production relationship: negatively_regulates GO:0032641 ! lymphotoxin A production [Term] id: GO:0032722 name: positive regulation of chemokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of chemokine production." [GOC:mah] synonym: "activation of chemokine production" NARROW [] synonym: "stimulation of chemokine production" NARROW [] synonym: "up regulation of chemokine production" EXACT [] synonym: "up-regulation of chemokine production" EXACT [] synonym: "upregulation of chemokine production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032642 ! regulation of chemokine production relationship: positively_regulates GO:0032602 ! chemokine production [Term] id: GO:0032723 name: positive regulation of connective tissue growth factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "activation of connective tissue growth factor production" NARROW [] synonym: "positive regulation of CCN2 production" EXACT [] synonym: "positive regulation of CTGF production" EXACT [] synonym: "positive regulation of Fisp12 production" EXACT [] synonym: "positive regulation of Hcs24 production" EXACT [] synonym: "positive regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "positive regulation of IGFBP8 production" EXACT [] synonym: "stimulation of connective tissue growth factor production" NARROW [] synonym: "up regulation of connective tissue growth factor production" EXACT [] synonym: "up-regulation of connective tissue growth factor production" EXACT [] synonym: "upregulation of connective tissue growth factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032643 ! regulation of connective tissue growth factor production relationship: positively_regulates GO:0032601 ! connective tissue growth factor production [Term] id: GO:0032724 name: positive regulation of fractalkine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of fractalkine production." [GOC:mah] synonym: "activation of fractalkine production" NARROW [] synonym: "stimulation of fractalkine production" NARROW [] synonym: "up regulation of fractalkine production" EXACT [] synonym: "up-regulation of fractalkine production" EXACT [] synonym: "upregulation of fractalkine production" EXACT [] is_a: GO:0032644 ! regulation of fractalkine production is_a: GO:0032722 ! positive regulation of chemokine production relationship: positively_regulates GO:0032603 ! fractalkine production [Term] id: GO:0032725 name: positive regulation of granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] synonym: "activation of granulocyte macrophage colony-stimulating factor production" NARROW [] synonym: "positive regulation of granulocyte macrophage colony stimulating factor production" EXACT [] synonym: "stimulation of granulocyte macrophage colony-stimulating factor production" NARROW [] synonym: "up regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "up-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "upregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production relationship: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0032726 name: positive regulation of hepatocyte growth factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] synonym: "activation of hepatocyte growth factor production" NARROW [] synonym: "stimulation of hepatocyte growth factor production" NARROW [] synonym: "up regulation of hepatocyte growth factor production" EXACT [] synonym: "up-regulation of hepatocyte growth factor production" EXACT [] synonym: "upregulation of hepatocyte growth factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032646 ! regulation of hepatocyte growth factor production relationship: positively_regulates GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0032727 name: positive regulation of interferon-alpha production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah] synonym: "activation of interferon-alpha production" NARROW [] synonym: "stimulation of interferon-alpha production" NARROW [] synonym: "up regulation of interferon-alpha production" EXACT [] synonym: "up-regulation of interferon-alpha production" EXACT [] synonym: "upregulation of interferon-alpha production" EXACT [] is_a: GO:0032481 ! positive regulation of type I interferon production is_a: GO:0032647 ! regulation of interferon-alpha production relationship: positively_regulates GO:0032607 ! interferon-alpha production [Term] id: GO:0032728 name: positive regulation of interferon-beta production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah] synonym: "activation of interferon-beta production" NARROW [] synonym: "positive regulation of IFN-beta production" EXACT [] synonym: "stimulation of interferon-beta production" NARROW [] synonym: "up regulation of interferon-beta production" EXACT [] synonym: "up-regulation of interferon-beta production" EXACT [] synonym: "upregulation of interferon-beta production" EXACT [] is_a: GO:0032481 ! positive regulation of type I interferon production is_a: GO:0032648 ! regulation of interferon-beta production relationship: positively_regulates GO:0032608 ! interferon-beta production [Term] id: GO:0032729 name: positive regulation of interferon-gamma production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "activation of interferon-gamma production" NARROW [] synonym: "positive regulation of type II interferon production" EXACT [] synonym: "stimulation of interferon-gamma production" NARROW [] synonym: "up regulation of interferon-gamma production" EXACT [] synonym: "up-regulation of interferon-gamma production" EXACT [] synonym: "upregulation of interferon-gamma production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032649 ! regulation of interferon-gamma production relationship: positively_regulates GO:0032609 ! interferon-gamma production [Term] id: GO:0032730 name: positive regulation of interleukin-1 alpha production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "activation of interleukin-1 alpha production" NARROW [] synonym: "positive regulation of IL-1 alpha production" EXACT [] synonym: "stimulation of interleukin-1 alpha production" NARROW [] synonym: "up regulation of interleukin-1 alpha production" EXACT [] synonym: "up-regulation of interleukin-1 alpha production" EXACT [] synonym: "upregulation of interleukin-1 alpha production" EXACT [] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0032732 ! positive regulation of interleukin-1 production relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0032731 name: positive regulation of interleukin-1 beta production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "activation of interleukin-1 beta production" NARROW [] synonym: "positive regulation of IL-1 beta production" EXACT [] synonym: "stimulation of interleukin-1 beta production" NARROW [] synonym: "up regulation of interleukin-1 beta production" EXACT [] synonym: "up-regulation of interleukin-1 beta production" EXACT [] synonym: "upregulation of interleukin-1 beta production" EXACT [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0032732 ! positive regulation of interleukin-1 production relationship: positively_regulates GO:0032611 ! interleukin-1 beta production [Term] id: GO:0032732 name: positive regulation of interleukin-1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "activation of interleukin-1 production" NARROW [] synonym: "positive regulation of IL-1 production" EXACT [] synonym: "stimulation of interleukin-1 production" NARROW [] synonym: "up regulation of interleukin-1 production" EXACT [] synonym: "up-regulation of interleukin-1 production" EXACT [] synonym: "upregulation of interleukin-1 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032652 ! regulation of interleukin-1 production relationship: positively_regulates GO:0032612 ! interleukin-1 production [Term] id: GO:0032733 name: positive regulation of interleukin-10 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "activation of interleukin-10 production" NARROW [] synonym: "positive regulation of IL-10 production" EXACT [] synonym: "stimulation of interleukin-10 production" NARROW [] synonym: "up regulation of interleukin-10 production" EXACT [] synonym: "up-regulation of interleukin-10 production" EXACT [] synonym: "upregulation of interleukin-10 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032653 ! regulation of interleukin-10 production relationship: positively_regulates GO:0032613 ! interleukin-10 production [Term] id: GO:0032734 name: positive regulation of interleukin-11 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "activation of interleukin-11 production" NARROW [] synonym: "positive regulation of IL-11 production" EXACT [] synonym: "stimulation of interleukin-11 production" NARROW [] synonym: "up regulation of interleukin-11 production" EXACT [] synonym: "up-regulation of interleukin-11 production" EXACT [] synonym: "upregulation of interleukin-11 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032654 ! regulation of interleukin-11 production relationship: positively_regulates GO:0032614 ! interleukin-11 production [Term] id: GO:0032735 name: positive regulation of interleukin-12 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "activation of interleukin-12 production" NARROW [] synonym: "positive regulation of IL-12 production" EXACT [] synonym: "stimulation of interleukin-12 production" NARROW [] synonym: "up regulation of interleukin-12 production" EXACT [] synonym: "up-regulation of interleukin-12 production" EXACT [] synonym: "upregulation of interleukin-12 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032655 ! regulation of interleukin-12 production relationship: positively_regulates GO:0032615 ! interleukin-12 production [Term] id: GO:0032736 name: positive regulation of interleukin-13 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "activation of interleukin-13 production" NARROW [] synonym: "positive regulation of IL-13 production" EXACT [] synonym: "stimulation of interleukin-13 production" NARROW [] synonym: "up regulation of interleukin-13 production" EXACT [] synonym: "up-regulation of interleukin-13 production" EXACT [] synonym: "upregulation of interleukin-13 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032656 ! regulation of interleukin-13 production relationship: positively_regulates GO:0032616 ! interleukin-13 production [Term] id: GO:0032737 name: positive regulation of interleukin-14 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "activation of interleukin-14 production" NARROW [] synonym: "positive regulation of IL-14 production" EXACT [] synonym: "stimulation of interleukin-14 production" NARROW [] synonym: "up regulation of interleukin-14 production" EXACT [] synonym: "up-regulation of interleukin-14 production" EXACT [] synonym: "upregulation of interleukin-14 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032657 ! regulation of interleukin-14 production relationship: positively_regulates GO:0032617 ! interleukin-14 production [Term] id: GO:0032738 name: positive regulation of interleukin-15 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "activation of interleukin-15 production" NARROW [] synonym: "positive regulation of IL-15 production" EXACT [] synonym: "stimulation of interleukin-15 production" NARROW [] synonym: "up regulation of interleukin-15 production" EXACT [] synonym: "up-regulation of interleukin-15 production" EXACT [] synonym: "upregulation of interleukin-15 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032658 ! regulation of interleukin-15 production relationship: positively_regulates GO:0032618 ! interleukin-15 production [Term] id: GO:0032739 name: positive regulation of interleukin-16 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "activation of interleukin-16 production" NARROW [] synonym: "positive regulation of IL-16 production" EXACT [] synonym: "stimulation of interleukin-16 production" NARROW [] synonym: "up regulation of interleukin-16 production" EXACT [] synonym: "up-regulation of interleukin-16 production" EXACT [] synonym: "upregulation of interleukin-16 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032659 ! regulation of interleukin-16 production relationship: positively_regulates GO:0032619 ! interleukin-16 production [Term] id: GO:0032740 name: positive regulation of interleukin-17 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-17 production." [GOC:mah] synonym: "activation of interleukin-17 production" NARROW [] synonym: "positive regulation of IL-17 production" EXACT [] synonym: "stimulation of interleukin-17 production" NARROW [] synonym: "up regulation of interleukin-17 production" EXACT [] synonym: "up-regulation of interleukin-17 production" EXACT [] synonym: "upregulation of interleukin-17 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032660 ! regulation of interleukin-17 production relationship: positively_regulates GO:0032620 ! interleukin-17 production [Term] id: GO:0032741 name: positive regulation of interleukin-18 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "activation of interleukin-18 production" NARROW [] synonym: "positive regulation of IL-18 production" EXACT [] synonym: "stimulation of interleukin-18 production" NARROW [] synonym: "up regulation of interleukin-18 production" EXACT [] synonym: "up-regulation of interleukin-18 production" EXACT [] synonym: "upregulation of interleukin-18 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032661 ! regulation of interleukin-18 production relationship: positively_regulates GO:0032621 ! interleukin-18 production [Term] id: GO:0032742 name: positive regulation of interleukin-19 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "activation of interleukin-19 production" NARROW [] synonym: "positive regulation of IL-19 production" EXACT [] synonym: "stimulation of interleukin-19 production" NARROW [] synonym: "up regulation of interleukin-19 production" EXACT [] synonym: "up-regulation of interleukin-19 production" EXACT [] synonym: "upregulation of interleukin-19 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032662 ! regulation of interleukin-19 production relationship: positively_regulates GO:0032622 ! interleukin-19 production [Term] id: GO:0032743 name: positive regulation of interleukin-2 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "activation of interleukin-2 production" NARROW [] synonym: "positive regulation of IL-2 production" EXACT [] synonym: "stimulation of interleukin-2 production" NARROW [] synonym: "up regulation of interleukin-2 production" EXACT [] synonym: "up-regulation of interleukin-2 production" EXACT [] synonym: "upregulation of interleukin-2 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032663 ! regulation of interleukin-2 production relationship: positively_regulates GO:0032623 ! interleukin-2 production [Term] id: GO:0032744 name: positive regulation of interleukin-20 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "activation of interleukin-20 production" NARROW [] synonym: "positive regulation of IL-20 production" EXACT [] synonym: "stimulation of interleukin-20 production" NARROW [] synonym: "up regulation of interleukin-20 production" EXACT [] synonym: "up-regulation of interleukin-20 production" EXACT [] synonym: "upregulation of interleukin-20 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032664 ! regulation of interleukin-20 production relationship: positively_regulates GO:0032624 ! interleukin-20 production [Term] id: GO:0032745 name: positive regulation of interleukin-21 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "activation of interleukin-21 production" NARROW [] synonym: "positive regulation of IL-21 production" EXACT [] synonym: "stimulation of interleukin-21 production" NARROW [] synonym: "up regulation of interleukin-21 production" EXACT [] synonym: "up-regulation of interleukin-21 production" EXACT [] synonym: "upregulation of interleukin-21 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032665 ! regulation of interleukin-21 production relationship: positively_regulates GO:0032625 ! interleukin-21 production [Term] id: GO:0032746 name: positive regulation of interleukin-22 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "activation of interleukin-22 production" NARROW [] synonym: "positive regulation of IL-22 production" EXACT [] synonym: "stimulation of interleukin-22 production" NARROW [] synonym: "up regulation of interleukin-22 production" EXACT [] synonym: "up-regulation of interleukin-22 production" EXACT [] synonym: "upregulation of interleukin-22 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032666 ! regulation of interleukin-22 production relationship: positively_regulates GO:0032626 ! interleukin-22 production [Term] id: GO:0032747 name: positive regulation of interleukin-23 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "activation of interleukin-23 production" NARROW [] synonym: "positive regulation of IL-23 production" EXACT [] synonym: "stimulation of interleukin-23 production" NARROW [] synonym: "up regulation of interleukin-23 production" EXACT [] synonym: "up-regulation of interleukin-23 production" EXACT [] synonym: "upregulation of interleukin-23 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032667 ! regulation of interleukin-23 production relationship: positively_regulates GO:0032627 ! interleukin-23 production [Term] id: GO:0032748 name: positive regulation of interleukin-24 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "activation of interleukin-24 production" NARROW [] synonym: "positive regulation of IL-24 production" EXACT [] synonym: "stimulation of interleukin-24 production" NARROW [] synonym: "up regulation of interleukin-24 production" EXACT [] synonym: "up-regulation of interleukin-24 production" EXACT [] synonym: "upregulation of interleukin-24 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032668 ! regulation of interleukin-24 production relationship: positively_regulates GO:0032628 ! interleukin-24 production [Term] id: GO:0032749 name: positive regulation of interleukin-25 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "activation of interleukin-25 production" NARROW [] synonym: "positive regulation of IL-25 production" EXACT [] synonym: "stimulation of interleukin-25 production" NARROW [] synonym: "up regulation of interleukin-25 production" EXACT [] synonym: "up-regulation of interleukin-25 production" EXACT [] synonym: "upregulation of interleukin-25 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032669 ! regulation of interleukin-25 production relationship: positively_regulates GO:0032629 ! interleukin-25 production [Term] id: GO:0032750 name: positive regulation of interleukin-26 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "activation of interleukin-26 production" NARROW [] synonym: "positive regulation of IL-26 production" EXACT [] synonym: "stimulation of interleukin-26 production" NARROW [] synonym: "up regulation of interleukin-26 production" EXACT [] synonym: "up-regulation of interleukin-26 production" EXACT [] synonym: "upregulation of interleukin-26 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032670 ! regulation of interleukin-26 production relationship: positively_regulates GO:0032630 ! interleukin-26 production [Term] id: GO:0032751 name: positive regulation of interleukin-27 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "activation of interleukin-27 production" NARROW [] synonym: "positive regulation of IL-27 production" EXACT [] synonym: "stimulation of interleukin-27 production" NARROW [] synonym: "up regulation of interleukin-27 production" EXACT [] synonym: "up-regulation of interleukin-27 production" EXACT [] synonym: "upregulation of interleukin-27 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032671 ! regulation of interleukin-27 production relationship: positively_regulates GO:0032631 ! interleukin-27 production [Term] id: GO:0032752 name: positive regulation of interleukin-3 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "activation of interleukin-3 production" NARROW [] synonym: "positive regulation of IL-3 production" EXACT [] synonym: "stimulation of interleukin-3 production" NARROW [] synonym: "up regulation of interleukin-3 production" EXACT [] synonym: "up-regulation of interleukin-3 production" EXACT [] synonym: "upregulation of interleukin-3 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032672 ! regulation of interleukin-3 production relationship: positively_regulates GO:0032632 ! interleukin-3 production [Term] id: GO:0032753 name: positive regulation of interleukin-4 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "activation of interleukin-4 production" NARROW [] synonym: "positive regulation of IL-4 production" EXACT [] synonym: "stimulation of interleukin-4 production" NARROW [] synonym: "up regulation of interleukin-4 production" EXACT [] synonym: "up-regulation of interleukin-4 production" EXACT [] synonym: "upregulation of interleukin-4 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032673 ! regulation of interleukin-4 production relationship: positively_regulates GO:0032633 ! interleukin-4 production [Term] id: GO:0032754 name: positive regulation of interleukin-5 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "activation of interleukin-5 production" NARROW [] synonym: "positive regulation of IL-5 production" EXACT [] synonym: "stimulation of interleukin-5 production" NARROW [] synonym: "up regulation of interleukin-5 production" EXACT [] synonym: "up-regulation of interleukin-5 production" EXACT [] synonym: "upregulation of interleukin-5 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032674 ! regulation of interleukin-5 production relationship: positively_regulates GO:0032634 ! interleukin-5 production [Term] id: GO:0032755 name: positive regulation of interleukin-6 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "activation of interleukin-6 production" NARROW [] synonym: "positive regulation of IL-6 production" EXACT [] synonym: "stimulation of interleukin-6 production" NARROW [] synonym: "up regulation of interleukin-6 production" EXACT [] synonym: "up-regulation of interleukin-6 production" EXACT [] synonym: "upregulation of interleukin-6 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032675 ! regulation of interleukin-6 production relationship: positively_regulates GO:0032635 ! interleukin-6 production [Term] id: GO:0032756 name: positive regulation of interleukin-7 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "activation of interleukin-7 production" NARROW [] synonym: "positive regulation of IL-7 production" EXACT [] synonym: "stimulation of interleukin-7 production" NARROW [] synonym: "up regulation of interleukin-7 production" EXACT [] synonym: "up-regulation of interleukin-7 production" EXACT [] synonym: "upregulation of interleukin-7 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032676 ! regulation of interleukin-7 production relationship: positively_regulates GO:0032636 ! interleukin-7 production [Term] id: GO:0032757 name: positive regulation of interleukin-8 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "activation of interleukin-8 production" NARROW [] synonym: "positive regulation of IL-8 production" EXACT [] synonym: "stimulation of interleukin-8 production" NARROW [] synonym: "up regulation of interleukin-8 production" EXACT [] synonym: "up-regulation of interleukin-8 production" EXACT [] synonym: "upregulation of interleukin-8 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032677 ! regulation of interleukin-8 production relationship: positively_regulates GO:0032637 ! interleukin-8 production [Term] id: GO:0032758 name: positive regulation of interleukin-9 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "activation of interleukin-9 production" NARROW [] synonym: "positive regulation of IL-9 production" EXACT [] synonym: "stimulation of interleukin-9 production" NARROW [] synonym: "up regulation of interleukin-9 production" EXACT [] synonym: "up-regulation of interleukin-9 production" EXACT [] synonym: "upregulation of interleukin-9 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032678 ! regulation of interleukin-9 production relationship: positively_regulates GO:0032638 ! interleukin-9 production [Term] id: GO:0032759 name: positive regulation of TRAIL production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of TRAIL production." [GOC:mah] synonym: "activation of TRAIL production" NARROW [] synonym: "stimulation of TRAIL production" NARROW [] synonym: "up regulation of TRAIL production" EXACT [] synonym: "up-regulation of TRAIL production" EXACT [] synonym: "upregulation of TRAIL production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032679 ! regulation of TRAIL production relationship: positively_regulates GO:0032639 ! TRAIL production [Term] id: GO:0032760 name: positive regulation of tumor necrosis factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "activation of tumor necrosis factor production" NARROW [] synonym: "positive regulation of TNF production" EXACT [] synonym: "positive regulation of TNF-alpha production" EXACT [] synonym: "positive regulation of tumor necrosis factor-alpha production" EXACT [] synonym: "stimulation of tumor necrosis factor production" NARROW [] synonym: "up regulation of tumor necrosis factor production" EXACT [] synonym: "up-regulation of tumor necrosis factor production" EXACT [] synonym: "upregulation of tumor necrosis factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032680 ! regulation of tumor necrosis factor production relationship: positively_regulates GO:0032640 ! tumor necrosis factor production [Term] id: GO:0032761 name: positive regulation of lymphotoxin A production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] synonym: "activation of lymphotoxin A production" NARROW [] synonym: "positive regulation of LTA production" EXACT [] synonym: "positive regulation of lymphotoxin-alpha production" EXACT [] synonym: "positive regulation of TNF-beta production" EXACT [] synonym: "positive regulation of tumor necrosis factor-beta production" EXACT [] synonym: "stimulation of lymphotoxin A production" NARROW [] synonym: "up regulation of lymphotoxin A production" EXACT [] synonym: "up-regulation of lymphotoxin A production" EXACT [] synonym: "upregulation of lymphotoxin A production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032681 ! regulation of lymphotoxin A production relationship: positively_regulates GO:0032641 ! lymphotoxin A production [Term] id: GO:0032762 name: mast cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah] is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0032763 name: regulation of mast cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0032762 ! mast cell cytokine production [Term] id: GO:0032764 name: negative regulation of mast cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] synonym: "down regulation of mast cell cytokine production" EXACT [] synonym: "down-regulation of mast cell cytokine production" EXACT [] synonym: "downregulation of mast cell cytokine production" EXACT [] synonym: "inhibition of mast cell cytokine production" NARROW [] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0032763 ! regulation of mast cell cytokine production relationship: negatively_regulates GO:0032762 ! mast cell cytokine production [Term] id: GO:0032765 name: positive regulation of mast cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] synonym: "activation of mast cell cytokine production" NARROW [] synonym: "stimulation of mast cell cytokine production" NARROW [] synonym: "up regulation of mast cell cytokine production" EXACT [] synonym: "up-regulation of mast cell cytokine production" EXACT [] synonym: "upregulation of mast cell cytokine production" EXACT [] is_a: GO:0032763 ! regulation of mast cell cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response relationship: positively_regulates GO:0032762 ! mast cell cytokine production [Term] id: GO:0032766 name: NHE3/E3KARP/ACTN4 complex namespace: cellular_component def: "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments." [PMID:11948184] synonym: "NHE3/E3KARP/alpha-actinin complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0032767 name: copper-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper." [GOC:ecd, PMID:16884690] is_a: GO:0005515 ! protein binding [Term] id: GO:0032768 name: regulation of monooxygenase activity namespace: biological_process def: "Any process that modulates the activity of a monooxygenase." [GOC:mah] subset: gosubset_prok is_a: GO:0051341 ! regulation of oxidoreductase activity [Term] id: GO:0032769 name: negative regulation of monooxygenase activity namespace: biological_process def: "Any process that stops or reduces the activity of a monooxygenase." [GOC:mah] synonym: "down regulation of monooxygenase activity" EXACT [] synonym: "down-regulation of monooxygenase activity" EXACT [] synonym: "downregulation of monooxygenase activity" EXACT [] synonym: "inhibition of monooxygenase activity" NARROW [] is_a: GO:0032768 ! regulation of monooxygenase activity is_a: GO:0051354 ! negative regulation of oxidoreductase activity [Term] id: GO:0032770 name: positive regulation of monooxygenase activity namespace: biological_process def: "Any process that activates or increases the activity of a monooxygenase." [GOC:mah] synonym: "activation of monooxygenase activity" NARROW [] synonym: "stimulation of monooxygenase activity" NARROW [] synonym: "up regulation of monooxygenase activity" EXACT [] synonym: "up-regulation of monooxygenase activity" EXACT [] synonym: "upregulation of monooxygenase activity" EXACT [] is_a: GO:0032768 ! regulation of monooxygenase activity is_a: GO:0051353 ! positive regulation of oxidoreductase activity [Term] id: GO:0032771 name: regulation of monophenol monooxygenase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] synonym: "regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0032768 ! regulation of monooxygenase activity [Term] id: GO:0032772 name: negative regulation of monophenol monooxygenase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of monophenol oxygenase activity" EXACT [] synonym: "down-regulation of monophenol oxygenase activity" EXACT [] synonym: "downregulation of monophenol oxygenase activity" EXACT [] synonym: "inhibition of monophenol oxygenase activity" NARROW [] synonym: "negative regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:0032771 ! regulation of monophenol monooxygenase activity [Term] id: GO:0032773 name: positive regulation of monophenol monooxygenase activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme monophenol oxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] synonym: "activation of monophenol oxygenase activity" NARROW [] synonym: "positive regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] synonym: "stimulation of monophenol oxygenase activity" NARROW [] synonym: "up regulation of monophenol oxygenase activity" EXACT [] synonym: "up-regulation of monophenol oxygenase activity" EXACT [] synonym: "upregulation of monophenol oxygenase activity" EXACT [] is_a: GO:0032770 ! positive regulation of monooxygenase activity is_a: GO:0032771 ! regulation of monophenol monooxygenase activity [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers." [GOC:mah] synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0032775 name: DNA methylation on adenine namespace: biological_process def: "The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf] synonym: "adenine methylation" RELATED [] is_a: GO:0006306 ! DNA methylation [Term] id: GO:0032776 name: DNA methylation on cytosine namespace: biological_process def: "The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule." [GOC:pf] synonym: "cytosine methylation" BROAD [] is_a: GO:0006306 ! DNA methylation [Term] id: GO:0032777 name: Piccolo NuA4 histone acetyltransferase complex namespace: cellular_component def: "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [PMID:12782659, PMID:15964809] is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex [Term] id: GO:0032778 name: cobalt-transporting ATPase activity namespace: molecular_function alt_id: GO:0015632 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] synonym: "cobalt ABC transporter" RELATED [] synonym: "cobalt porter activity" RELATED [] synonym: "cobalt transporting ATPase activity" EXACT [] is_a: GO:0015087 ! cobalt ion transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0032779 name: copper-induced intracellular protein transport namespace: biological_process def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell, induced by an increase in copper ion concentration." [GOC:ecd, PMID:12572677] is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0032780 name: negative regulation of ATPase activity namespace: biological_process def: "Any process that stops or reduces the rate of ATP hydrolysis by an ATPase." [GOC:mah] synonym: "down regulation of ATPase activity" EXACT [] synonym: "down-regulation of ATPase activity" EXACT [] synonym: "downregulation of ATPase activity" EXACT [] synonym: "inhibition of ATPase activity" NARROW [] synonym: "negative regulation of adenosinetriphosphatase activity" EXACT [] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0032781 name: positive regulation of ATPase activity namespace: biological_process def: "Any process that activates or increases the rate of ATP hydrolysis by an ATPase." [GOC:mah] synonym: "activation of ATPase activity" NARROW [] synonym: "positive regulation of adenosinetriphosphatase activity" EXACT [] synonym: "stimulation of ATPase activity" NARROW [] synonym: "up regulation of ATPase activity" EXACT [] synonym: "up-regulation of ATPase activity" EXACT [] synonym: "upregulation of ATPase activity" EXACT [] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0032782 name: bile acid secretion namespace: biological_process def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or group of cells." [GOC:ecd] is_a: GO:0046717 ! acid secretion [Term] id: GO:0032783 name: ELL-EAF complex namespace: cellular_component def: "A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0032784 name: regulation of transcription elongation, DNA-dependent namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "regulation of RNA elongation" BROAD [] synonym: "regulation of transcriptional elongation" BROAD [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent relationship: regulates GO:0006354 ! transcription elongation, DNA-dependent [Term] id: GO:0032785 name: negative regulation of transcription elongation, DNA-dependent namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "down regulation of RNA elongation" BROAD [] synonym: "down-regulation of RNA elongation" BROAD [] synonym: "downregulation of RNA elongation" BROAD [] synonym: "inhibition of RNA elongation" BROAD [] synonym: "negative regulation of transcription elongation" BROAD [] synonym: "negative regulation of transcriptional elongation" BROAD [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0032784 ! regulation of transcription elongation, DNA-dependent is_a: GO:0051253 ! negative regulation of RNA metabolic process relationship: negatively_regulates GO:0006354 ! transcription elongation, DNA-dependent [Term] id: GO:0032786 name: positive regulation of transcription elongation, DNA-dependent namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "activation of RNA elongation" BROAD [] synonym: "positive regulation of transcription elongation" BROAD [] synonym: "positive regulation of transcriptional elongation" BROAD [] synonym: "stimulation of RNA elongation" BROAD [] synonym: "up regulation of RNA elongation" BROAD [] synonym: "up-regulation of RNA elongation" BROAD [] synonym: "upregulation of RNA elongation" BROAD [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032784 ! regulation of transcription elongation, DNA-dependent is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0006354 ! transcription elongation, DNA-dependent [Term] id: GO:0032787 name: monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] subset: gosubset_prok synonym: "monocarboxylate metabolic process" EXACT [] synonym: "monocarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0032788 name: saturated monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds." [GOC:mah, GOC:vk] synonym: "saturated monocarboxylate metabolic process" EXACT [] synonym: "saturated monocarboxylic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0032789 name: unsaturated monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds." [GOC:mah, GOC:vk] synonym: "unsaturated monocarboxylate metabolic process" EXACT [] synonym: "unsaturated monocarboxylic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0032790 name: ribosome disassembly namespace: biological_process def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] synonym: "ribosome dissociation factor" RELATED [] is_a: GO:0032988 ! ribonucleoprotein complex disassembly [Term] id: GO:0032791 name: lead ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with lead (Pb) ions." [GOC:mah] subset: gosubset_prok is_a: GO:0046872 ! metal ion binding [Term] id: GO:0032792 name: negative regulation of CREB transcription factor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] synonym: "CREB inhibitor" RELATED [] synonym: "inhibition of CREB transcription factor" EXACT [GOC:dph, GOC:tb] is_a: GO:0043433 ! negative regulation of sequence-specific DNA binding transcription factor activity [Term] id: GO:0032793 name: positive regulation of CREB transcription factor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] synonym: "activation of CREB" EXACT [] synonym: "activation of CREB transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "CREB activator" RELATED [] is_a: GO:0051091 ! positive regulation of sequence-specific DNA binding transcription factor activity [Term] id: GO:0032794 name: GTPase activating protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln] synonym: "GAP binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0032795 name: heterotrimeric G-protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heterotrimeric G-protein." [GOC:nln] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0032796 name: uropod organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12714569, PMID:12787750] synonym: "uropod organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030030 ! cell projection organization [Term] id: GO:0032797 name: SMN complex namespace: cellular_component def: "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'. synonym: "SMN core complex" EXACT [] synonym: "survival motor neuron complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032798 name: Swi5-Sfr1 complex namespace: cellular_component def: "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379] comment: Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p. synonym: "Sae3-Mei5 complex" EXACT [GOC:elh, GOC:vw] synonym: "Swi5 complex" BROAD [] is_a: GO:0033061 ! DNA recombinase mediator complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0032799 name: low-density lipoprotein receptor particle metabolic process namespace: biological_process def: "The chemical reactions and pathways involving low-density lipoprotein receptors." [GOC:vk] synonym: "LDL receptor metabolic process" EXACT [] synonym: "low-density lipoprotein receptor metabolism" EXACT [] synonym: "low-density lipoprotein receptor particle metabolic process" EXACT [GOC:dph] is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0032800 name: receptor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] synonym: "receptor anabolism" EXACT [] synonym: "receptor biosynthesis" EXACT [] synonym: "receptor formation" EXACT [] synonym: "receptor synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0032801 name: receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] synonym: "receptor breakdown" EXACT [] synonym: "receptor catabolism" EXACT [] synonym: "receptor degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0043112 ! receptor metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0032802 name: low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] synonym: "LDL receptor breakdown" EXACT [] synonym: "LDL receptor catabolic process" EXACT [] synonym: "LDL receptor catabolism" RELATED [] synonym: "LDL receptor degradation" EXACT [] synonym: "low-density lipoprotein receptor breakdown" EXACT [] synonym: "low-density lipoprotein receptor catabolic process" EXACT [GOC:dph] synonym: "low-density lipoprotein receptor catabolism" EXACT [] synonym: "low-density lipoprotein receptor degradation" EXACT [] is_a: GO:0032799 ! low-density lipoprotein receptor particle metabolic process is_a: GO:0032801 ! receptor catabolic process is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0032803 name: regulation of low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah] synonym: "regulation of LDLr catabolic process" EXACT [] synonym: "regulation of LDLr catabolism" EXACT [] synonym: "regulation of low-density lipoprotein particle receptor catabolic process" EXACT [GOC:dph] synonym: "regulation of low-density lipoprotein receptor breakdown" EXACT [] synonym: "regulation of low-density lipoprotein receptor catabolism" EXACT [] synonym: "regulation of low-density lipoprotein receptor degradation" EXACT [] is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:2000644 ! regulation of receptor catabolic process relationship: regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process [Term] id: GO:0032804 name: negative regulation of low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah] synonym: "down regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "down-regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "downregulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "inhibition of low-density lipoprotein receptor catabolic process" NARROW [] synonym: "negative regulation of low-density lipoprotein receptor breakdown" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:dph] synonym: "negative regulation of low-density lipoprotein receptor catabolism" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor degradation" EXACT [] is_a: GO:0032269 ! negative regulation of cellular protein metabolic process is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:2000645 ! negative regulation of receptor catabolic process relationship: negatively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process [Term] id: GO:0032805 name: positive regulation of low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah] synonym: "activation of low-density lipoprotein receptor catabolic process" NARROW [] synonym: "positive regulation of low-density lipoprotein particle receptor catabolic process" EXACT [GOC:dph] synonym: "positive regulation of low-density lipoprotein receptor breakdown" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor catabolism" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor degradation" EXACT [] synonym: "stimulation of low-density lipoprotein receptor catabolic process" NARROW [] synonym: "up regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "up-regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "upregulation of low-density lipoprotein receptor catabolic process" EXACT [] is_a: GO:0032270 ! positive regulation of cellular protein metabolic process is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:2000646 ! positive regulation of receptor catabolic process relationship: positively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process [Term] id: GO:0032806 name: carboxy-terminal domain protein kinase complex namespace: cellular_component def: "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] synonym: "CTDK complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032807 name: DNA ligase IV complex namespace: cellular_component def: "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p." [PMID:16314503] synonym: "DNA ligase IV-XRCC4 complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032808 name: lacrimal gland development namespace: biological_process def: "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye." [GOC:ln] is_a: GO:0048732 ! gland development relationship: part_of GO:0035272 ! exocrine system development [Term] id: GO:0032809 name: neuronal cell body membrane namespace: cellular_component def: "The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites." [GOC:jl] synonym: "neuron cell body membrane" EXACT [] synonym: "neuronal cell soma membrane" EXACT [] is_a: GO:0044298 ! cell body membrane relationship: part_of GO:0043025 ! neuronal cell body [Term] id: GO:0032810 name: sterol response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "SRE binding" EXACT [] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0032811 name: negative regulation of epinephrine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] synonym: "down regulation of epinephrine secretion" EXACT [] synonym: "down-regulation of epinephrine secretion" EXACT [] synonym: "downregulation of epinephrine secretion" EXACT [] synonym: "inhibition of epinephrine secretion" NARROW [] synonym: "negative regulation of adrenaline secretion" EXACT [] is_a: GO:0014060 ! regulation of epinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion relationship: negatively_regulates GO:0048242 ! epinephrine secretion [Term] id: GO:0032812 name: positive regulation of epinephrine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] synonym: "activation of epinephrine secretion" NARROW [] synonym: "positive regulation of adrenaline secretion" EXACT [] synonym: "stimulation of epinephrine secretion" NARROW [] synonym: "up regulation of epinephrine secretion" EXACT [] synonym: "up-regulation of epinephrine secretion" EXACT [] synonym: "upregulation of epinephrine secretion" EXACT [] is_a: GO:0014060 ! regulation of epinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion relationship: positively_regulates GO:0048242 ! epinephrine secretion [Term] id: GO:0032813 name: tumor necrosis factor receptor superfamily binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily." [GOC:add] synonym: "TNF receptor superfamily binding" EXACT [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0032814 name: regulation of natural killer cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "regulation of NK cell activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation relationship: regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032815 name: negative regulation of natural killer cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "down regulation of natural killer cell activation" EXACT [] synonym: "down-regulation of natural killer cell activation" EXACT [] synonym: "downregulation of natural killer cell activation" EXACT [] synonym: "inhibition of natural killer cell activation" NARROW [] synonym: "negative regulation of NK cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation relationship: negatively_regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032816 name: positive regulation of natural killer cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "activation of natural killer cell activation" NARROW [] synonym: "positive regulation of NK cell activation" EXACT [] synonym: "stimulation of natural killer cell activation" NARROW [] synonym: "up regulation of natural killer cell activation" EXACT [] synonym: "up-regulation of natural killer cell activation" EXACT [] synonym: "upregulation of natural killer cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation relationship: positively_regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032817 name: regulation of natural killer cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "regulation of NK cell proliferation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0050670 ! regulation of lymphocyte proliferation relationship: regulates GO:0001787 ! natural killer cell proliferation [Term] id: GO:0032818 name: negative regulation of natural killer cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "down regulation of natural killer cell proliferation" EXACT [] synonym: "down-regulation of natural killer cell proliferation" EXACT [] synonym: "downregulation of natural killer cell proliferation" EXACT [] synonym: "inhibition of natural killer cell proliferation" NARROW [] synonym: "negative regulation of NK cell proliferation" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation relationship: negatively_regulates GO:0001787 ! natural killer cell proliferation [Term] id: GO:0032819 name: positive regulation of natural killer cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "activation of natural killer cell proliferation" NARROW [] synonym: "positive regulation of NK cell proliferation" EXACT [] synonym: "stimulation of natural killer cell proliferation" NARROW [] synonym: "up regulation of natural killer cell proliferation" EXACT [] synonym: "up-regulation of natural killer cell proliferation" EXACT [] synonym: "upregulation of natural killer cell proliferation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation relationship: positively_regulates GO:0001787 ! natural killer cell proliferation [Term] id: GO:0032820 name: regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "regulation of NK cell proliferation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002324 ! natural killer cell proliferation involved in immune response [Term] id: GO:0032821 name: negative regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "down regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "down-regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "downregulation of natural killer cell proliferation during immune response" RELATED [] synonym: "inhibition of natural killer cell proliferation during immune response" NARROW [] synonym: "negative regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "negative regulation of NK cell proliferation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032818 ! negative regulation of natural killer cell proliferation is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response relationship: negatively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response [Term] id: GO:0032822 name: positive regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "activation of natural killer cell proliferation during immune response" NARROW [] synonym: "positive regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "positive regulation of NK cell proliferation during immune response" RELATED [] synonym: "stimulation of natural killer cell proliferation during immune response" NARROW [] synonym: "up regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "up-regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "upregulation of natural killer cell proliferation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032819 ! positive regulation of natural killer cell proliferation is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response relationship: positively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response [Term] id: GO:0032823 name: regulation of natural killer cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer cell development" RELATED [GOC:add] synonym: "regulation of NK cell differentiation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0045619 ! regulation of lymphocyte differentiation relationship: regulates GO:0001779 ! natural killer cell differentiation [Term] id: GO:0032824 name: negative regulation of natural killer cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of natural killer cell differentiation" EXACT [] synonym: "down-regulation of natural killer cell differentiation" EXACT [] synonym: "downregulation of natural killer cell differentiation" EXACT [] synonym: "inhibition of natural killer cell differentiation" NARROW [] synonym: "negative regulation of natural killer cell development" RELATED [GOC:add] synonym: "negative regulation of NK cell differentiation" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation relationship: negatively_regulates GO:0001779 ! natural killer cell differentiation [Term] id: GO:0032825 name: positive regulation of natural killer cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of natural killer cell differentiation" NARROW [] synonym: "positive regulation of natural killer cell development" RELATED [GOC:add] synonym: "positive regulation of NK cell differentiation" EXACT [] synonym: "stimulation of natural killer cell differentiation" NARROW [] synonym: "up regulation of natural killer cell differentiation" EXACT [] synonym: "up-regulation of natural killer cell differentiation" EXACT [] synonym: "upregulation of natural killer cell differentiation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation relationship: positively_regulates GO:0001779 ! natural killer cell differentiation [Term] id: GO:0032826 name: regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "regulation of NK cell differentiation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002325 ! natural killer cell differentiation involved in immune response [Term] id: GO:0032827 name: negative regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "down-regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "downregulation of natural killer cell differentiation during immune response" RELATED [] synonym: "inhibition of natural killer cell differentiation during immune response" NARROW [] synonym: "negative regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "negative regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "negative regulation of NK cell differentiation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032824 ! negative regulation of natural killer cell differentiation is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response relationship: negatively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response [Term] id: GO:0032828 name: positive regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of natural killer cell differentiation during immune response" NARROW [] synonym: "positive regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "positive regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "positive regulation of NK cell differentiation during immune response" RELATED [] synonym: "stimulation of natural killer cell differentiation during immune response" NARROW [] synonym: "up regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "up-regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "upregulation of natural killer cell differentiation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032825 ! positive regulation of natural killer cell differentiation is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response relationship: positively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response [Term] id: GO:0032829 name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation relationship: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032830 name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045590 ! negative regulation of regulatory T cell differentiation relationship: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032831 name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045591 ! positive regulation of regulatory T cell differentiation relationship: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032832 name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032833 name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032830 ! negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response relationship: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032834 name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response relationship: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032835 name: glomerulus development namespace: biological_process def: "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment." [GOC:mah, GOC:mtg_kidney_jan10] synonym: "glomerular development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072006 ! nephron development [Term] id: GO:0032836 name: glomerular basement membrane development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration." [GOC:sr] is_a: GO:0030198 ! extracellular matrix organization relationship: part_of GO:0032835 ! glomerulus development [Term] id: GO:0032837 name: distributive segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart] is_a: GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0032838 name: cell projection cytoplasm namespace: cellular_component def: "All of the contents of a cell projection, excluding the plasma membrane surrounding the projection." [GOC:mah] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044463 ! cell projection part [Term] id: GO:0032839 name: dendrite cytoplasm namespace: cellular_component def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah] synonym: "dendritic cytoplasm" EXACT [] is_a: GO:0032838 ! cell projection cytoplasm relationship: part_of GO:0030425 ! dendrite [Term] id: GO:0032840 name: intramolecular proline-rich ligand binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proline-rich region within the same polypeptide." [GOC:pf] synonym: "intramolecular proline-rich region binding" EXACT [] is_a: GO:0043621 ! protein self-association is_a: GO:0070064 ! proline-rich region binding [Term] id: GO:0032841 name: calcitonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd] is_a: GO:0017046 ! peptide hormone binding [Term] id: GO:0032843 name: hydroperoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol." [GOC:mlg, PMID:12540833] is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0032844 name: regulation of homeostatic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a homeostatic process." [GOC:mah] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0042592 ! homeostatic process [Term] id: GO:0032845 name: negative regulation of homeostatic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process." [GOC:mah] synonym: "down regulation of homeostatic process" EXACT [] synonym: "down-regulation of homeostatic process" EXACT [] synonym: "downregulation of homeostatic process" EXACT [] synonym: "inhibition of homeostatic process" NARROW [] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0042592 ! homeostatic process [Term] id: GO:0032846 name: positive regulation of homeostatic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a homeostatic process." [GOC:mah] synonym: "activation of homeostatic process" NARROW [] synonym: "stimulation of homeostatic process" NARROW [] synonym: "up regulation of homeostatic process" EXACT [] synonym: "up-regulation of homeostatic process" EXACT [] synonym: "upregulation of homeostatic process" EXACT [] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0042592 ! homeostatic process [Term] id: GO:0032847 name: regulation of cellular pH reduction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] synonym: "regulation of cell pH reduction" EXACT [] synonym: "regulation of cellular acidification" EXACT [] synonym: "regulation of intracellular acidification" RELATED [] synonym: "regulation of intracellular pH reduction" EXACT [] synonym: "regulation of reduction of cellular pH" EXACT [] synonym: "regulation of reduction of pH in cell" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:2000021 ! regulation of ion homeostasis relationship: regulates GO:0051452 ! intracellular pH reduction [Term] id: GO:0032848 name: negative regulation of cellular pH reduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] synonym: "down regulation of cellular pH reduction" EXACT [] synonym: "down-regulation of cellular pH reduction" EXACT [] synonym: "downregulation of cellular pH reduction" EXACT [] synonym: "inhibition of cellular pH reduction" NARROW [] synonym: "negative regulation of cell pH reduction" EXACT [] synonym: "negative regulation of cellular acidification" EXACT [] synonym: "negative regulation of intracellular acidification" RELATED [] synonym: "negative regulation of intracellular pH reduction" EXACT [] synonym: "negative regulation of reduction of cellular pH" EXACT [] synonym: "negative regulation of reduction of pH in cell" EXACT [] is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0032847 ! regulation of cellular pH reduction is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0051452 ! intracellular pH reduction [Term] id: GO:0032849 name: positive regulation of cellular pH reduction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] synonym: "activation of cellular pH reduction" NARROW [] synonym: "positive regulation of cell pH reduction" EXACT [] synonym: "positive regulation of cellular acidification" EXACT [] synonym: "positive regulation of intracellular acidification" RELATED [] synonym: "positive regulation of intracellular pH reduction" EXACT [] synonym: "positive regulation of reduction of cellular pH" EXACT [] synonym: "positive regulation of reduction of pH in cell" EXACT [] synonym: "stimulation of cellular pH reduction" NARROW [] synonym: "up regulation of cellular pH reduction" EXACT [] synonym: "up-regulation of cellular pH reduction" EXACT [] synonym: "upregulation of cellular pH reduction" EXACT [] is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0032847 ! regulation of cellular pH reduction is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0051452 ! intracellular pH reduction [Term] id: GO:0032850 name: positive regulation of ARF GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of the GTPase ARF." [GOC:mah] synonym: "stimulation of ARF GTPase activity" NARROW [] synonym: "up regulation of ARF GTPase activity" EXACT [] synonym: "up-regulation of ARF GTPase activity" EXACT [] synonym: "upregulation of ARF GTPase activity" EXACT [] is_a: GO:0032312 ! regulation of ARF GTPase activity is_a: GO:0032320 ! positive regulation of Ras GTPase activity [Term] id: GO:0032851 name: positive regulation of Rab GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of a GTPase of the Rab family." [GOC:mah] synonym: "stimulation of Rab GTPase activity" NARROW [] synonym: "up regulation of Rab GTPase activity" EXACT [] synonym: "up-regulation of Rab GTPase activity" EXACT [] synonym: "upregulation of Rab GTPase activity" EXACT [] is_a: GO:0032313 ! regulation of Rab GTPase activity is_a: GO:0032320 ! positive regulation of Ras GTPase activity [Term] id: GO:0032852 name: positive regulation of Ral GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of a GTPase of the Ral family." [GOC:mah] synonym: "stimulation of Ral GTPase activity" NARROW [] synonym: "up regulation of Ral GTPase activity" EXACT [] synonym: "up-regulation of Ral GTPase activity" EXACT [] synonym: "upregulation of Ral GTPase activity" EXACT [] is_a: GO:0032315 ! regulation of Ral GTPase activity is_a: GO:0032320 ! positive regulation of Ras GTPase activity [Term] id: GO:0032853 name: positive regulation of Ran GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of a GTPase of the Ran family." [GOC:mah] synonym: "stimulation of Ran GTPase activity" NARROW [] synonym: "up regulation of Ran GTPase activity" EXACT [] synonym: "up-regulation of Ran GTPase activity" EXACT [] synonym: "upregulation of Ran GTPase activity" EXACT [] is_a: GO:0032316 ! regulation of Ran GTPase activity is_a: GO:0032320 ! positive regulation of Ras GTPase activity [Term] id: GO:0032854 name: positive regulation of Rap GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of a GTPase of the Rap family." [GOC:mah] synonym: "stimulation of Rap GTPase activity" NARROW [] synonym: "up regulation of Rap GTPase activity" EXACT [] synonym: "up-regulation of Rap GTPase activity" EXACT [] synonym: "upregulation of Rap GTPase activity" EXACT [] is_a: GO:0032317 ! regulation of Rap GTPase activity is_a: GO:0032320 ! positive regulation of Ras GTPase activity [Term] id: GO:0032855 name: positive regulation of Rac GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of a GTPase of the Rac family." [GOC:mah] synonym: "stimulation of Rac GTPase activity" NARROW [] synonym: "up regulation of Rac GTPase activity" EXACT [] synonym: "up-regulation of Rac GTPase activity" EXACT [] synonym: "upregulation of Rac GTPase activity" EXACT [] is_a: GO:0032321 ! positive regulation of Rho GTPase activity [Term] id: GO:0032856 name: activation of Ras GTPase activity namespace: biological_process def: "Any process that initiates the activity of an inactive GTPase of the Ras superfamily through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] comment: Note that this term should not be confused with the molecular function term 'Ras GTPase activator activity ; GO:0005099', which refers specifically to the activity of Ras GAPs. synonym: "Ras GTPase activation" EXACT [] is_a: GO:0032320 ! positive regulation of Ras GTPase activity [Term] id: GO:0032857 name: activation of ARF GTPase activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme ARF GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] comment: Note that this term should not be confused with the molecular function term 'ARF GTPase activator activity ; GO:0008060', which refers specifically to the activity of ARF GAPs. synonym: "ARF GTPase activation" EXACT [] is_a: GO:0032850 ! positive regulation of ARF GTPase activity is_a: GO:0032856 ! activation of Ras GTPase activity [Term] id: GO:0032858 name: activation of Rab GTPase activity namespace: biological_process def: "Any process that initiates the activity of an inactive GTPase of the Rab family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] comment: Note that this term should not be confused with the molecular function term 'Rab GTPase activator activity ; GO:0005097', which refers specifically to the activity of Rab GAPs. synonym: "Rab GTPase activation" EXACT [] is_a: GO:0032851 ! positive regulation of Rab GTPase activity is_a: GO:0032856 ! activation of Ras GTPase activity [Term] id: GO:0032859 name: activation of Ral GTPase activity namespace: biological_process def: "Any process that initiates the activity of an inactive GTPase of the Ral family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] comment: Note that this term should not be confused with the molecular function term 'Ral GTPase activator activity ; GO:0017123', which refers specifically to the activity of Ral GAPs. synonym: "Ral GTPase activation" EXACT [] is_a: GO:0032852 ! positive regulation of Ral GTPase activity is_a: GO:0032856 ! activation of Ras GTPase activity [Term] id: GO:0032860 name: activation of Ran GTPase activity namespace: biological_process def: "Any process that initiates the activity of an inactive GTPase of the Ran family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] comment: Note that this term should not be confused with the molecular function term 'Ran GTPase activator activity ; GO:0005098', which refers specifically to the activity of Ran GAPs. synonym: "Ran GTPase activation" EXACT [] is_a: GO:0032853 ! positive regulation of Ran GTPase activity is_a: GO:0032856 ! activation of Ras GTPase activity [Term] id: GO:0032861 name: activation of Rap GTPase activity namespace: biological_process def: "Any process that initiates the activity of an inactive GTPase of the Rap family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] comment: Note that this term should not be confused with the molecular function term 'Rap GTPase activator activity ; GO:0046582', which refers specifically to the activity of Rap GAPs. synonym: "Rap GTPase activation" EXACT [] is_a: GO:0032854 ! positive regulation of Rap GTPase activity is_a: GO:0032856 ! activation of Ras GTPase activity [Term] id: GO:0032862 name: activation of Rho GTPase activity namespace: biological_process def: "Any process that initiates the activity of an inactive GTPase of the Rho family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] comment: Note that this term should not be confused with the molecular function term 'Rho GTPase activator activity ; GO:0005100', which refers specifically to the activity of Rho GAPs. synonym: "Rho GTPase activation" EXACT [] is_a: GO:0032321 ! positive regulation of Rho GTPase activity is_a: GO:0032856 ! activation of Ras GTPase activity [Term] id: GO:0032863 name: activation of Rac GTPase activity namespace: biological_process def: "Any process that initiates the activity of an inactive GTPase of the Rac family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] synonym: "Rac GTPase activation" EXACT [] is_a: GO:0032855 ! positive regulation of Rac GTPase activity is_a: GO:0032862 ! activation of Rho GTPase activity [Term] id: GO:0032864 name: activation of Cdc42 GTPase activity namespace: biological_process def: "Any process that initiates the activity of the inactive GTPase Cdc42 through the replacement of GDP by GTP." [GOC:mah] synonym: "Cdc42 GTPase activation" EXACT [] is_a: GO:0032862 ! activation of Rho GTPase activity is_a: GO:0043089 ! positive regulation of Cdc42 GTPase activity [Term] id: GO:0032865 name: ERMES complex namespace: cellular_component def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth." [GOC:mcc, PMID:19556461] synonym: "ER-mitochondria encounter structure" EXACT [] synonym: "Mdm10/Mdm12/Mmm1 complex" EXACT [] synonym: "mitochore" EXACT [GOC:mcc] synonym: "MMM1 complex" EXACT [GOC:mcc] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005741 ! mitochondrial outer membrane relationship: part_of GO:0044233 ! ER-mitochondrion membrane contact site [Term] id: GO:0032866 name: D-xylose:NADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+." [PMID:12724380, PMID:15184173] synonym: "D-xylose reductase activity" BROAD [] synonym: "xylose reductase activity" BROAD [] xref: EC:1.1.1.- xref: MetaCyc:RXN-8773 xref: RHEA:27448 is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity [Term] id: GO:0032867 name: L-arabinose:NADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+." [PMID:12724380, PMID:15184173] synonym: "arabinose reductase activity" BROAD [] synonym: "arabinose:NADP reductase activity" BROAD [] xref: EC:1.1.1.- xref: KEGG:R01759 xref: MetaCyc:RXN-8772 xref: SABIO-RK:1858 is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity [Term] id: GO:0032868 name: response to insulin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0043434 ! response to peptide hormone stimulus [Term] id: GO:0032869 name: cellular response to insulin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0032868 ! response to insulin stimulus is_a: GO:0071375 ! cellular response to peptide hormone stimulus [Term] id: GO:0032870 name: cellular response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone stimulus is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0032871 name: regulation of karyogamy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0000741 ! karyogamy [Term] id: GO:0032872 name: regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "regulation of p38 MAPK signaling" EXACT [] synonym: "regulation of p38 MAPK signalling" EXACT [] synonym: "regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "regulation of stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0043408 ! regulation of MAPKKK cascade is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade relationship: regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032873 name: negative regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "down regulation of stress-activated MAPK cascade" EXACT [] synonym: "down-regulation of stress-activated MAPK cascade" EXACT [] synonym: "downregulation of stress-activated MAPK cascade" EXACT [] synonym: "inhibition of stress-activated MAPK cascade" NARROW [] synonym: "negative regulation of p38 MAPK signaling" EXACT [] synonym: "negative regulation of p38 MAPK signalling" EXACT [] synonym: "negative regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "negative regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade is_a: GO:0043409 ! negative regulation of MAPKKK cascade is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling cascade relationship: negatively_regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032874 name: positive regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "activation of stress-activated MAPK cascade" NARROW [] synonym: "positive regulation of p38 MAPK signaling" EXACT [] synonym: "positive regulation of p38 MAPK signalling" EXACT [] synonym: "positive regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "positive regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPKKK signalling pathway" EXACT [] synonym: "stimulation of stress-activated MAPK cascade" NARROW [] synonym: "up regulation of stress-activated MAPK cascade" EXACT [] synonym: "up-regulation of stress-activated MAPK cascade" EXACT [] synonym: "upregulation of stress-activated MAPK cascade" EXACT [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade is_a: GO:0043410 ! positive regulation of MAPKKK cascade is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling cascade relationship: positively_regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032875 name: regulation of DNA endoreduplication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA endoreduplication." [GOC:mah] synonym: "regulation of DNA endoreplication" EXACT [] synonym: "regulation of DNA re-duplication" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: regulates GO:0042023 ! DNA endoreduplication [Term] id: GO:0032876 name: negative regulation of DNA endoreduplication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah] synonym: "down regulation of DNA endoreduplication" EXACT [] synonym: "down-regulation of DNA endoreduplication" EXACT [] synonym: "downregulation of DNA endoreduplication" EXACT [] synonym: "inhibition of DNA endoreduplication" NARROW [] synonym: "negative regulation of DNA endoreplication" EXACT [] synonym: "negative regulation of DNA re-duplication" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0032875 ! regulation of DNA endoreduplication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication relationship: negatively_regulates GO:0042023 ! DNA endoreduplication [Term] id: GO:0032877 name: positive regulation of DNA endoreduplication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah] synonym: "activation of DNA endoreduplication" NARROW [] synonym: "positive regulation of DNA endoreplication" EXACT [] synonym: "positive regulation of DNA re-duplication" EXACT [] synonym: "stimulation of DNA endoreduplication" NARROW [] synonym: "up regulation of DNA endoreduplication" EXACT [] synonym: "up-regulation of DNA endoreduplication" EXACT [] synonym: "upregulation of DNA endoreduplication" EXACT [] is_a: GO:0032875 ! regulation of DNA endoreduplication is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication relationship: positively_regulates GO:0042023 ! DNA endoreduplication [Term] id: GO:0032878 name: regulation of establishment or maintenance of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0032879 name: regulation of localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] subset: gosubset_prok synonym: "regulation of localisation" EXACT [GOC:mah] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0051179 ! localization [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: gosubset_prok synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization relationship: regulates GO:0008104 ! protein localization [Term] id: GO:0032881 name: regulation of polysaccharide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] subset: gosubset_prok is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0032882 name: regulation of chitin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah] synonym: "regulation of chitin metabolism" EXACT [] is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: regulates GO:0006030 ! chitin metabolic process [Term] id: GO:0032883 name: regulation of chitin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin." [GOC:mah] synonym: "regulation of chitin anabolism" EXACT [] synonym: "regulation of chitin biosynthesis" RELATED [] synonym: "regulation of chitin formation" EXACT [] synonym: "regulation of chitin synthesis" EXACT [] is_a: GO:0032882 ! regulation of chitin metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process relationship: regulates GO:0006031 ! chitin biosynthetic process [Term] id: GO:0032884 name: regulation of cell wall chitin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin." [GOC:mah] synonym: "regulation of cell wall chitin anabolism" EXACT [] synonym: "regulation of cell wall chitin biosynthesis" EXACT [] synonym: "regulation of cell wall chitin formation" EXACT [] synonym: "regulation of cell wall chitin synthesis" EXACT [] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032883 ! regulation of chitin biosynthetic process is_a: GO:0034222 ! regulation of cell wall chitin metabolic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0006038 ! cell wall chitin biosynthetic process [Term] id: GO:0032885 name: regulation of polysaccharide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] subset: gosubset_prok is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process relationship: regulates GO:0000271 ! polysaccharide biosynthetic process [Term] id: GO:0032886 name: regulation of microtubule-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007017 ! microtubule-based process [Term] id: GO:0032887 name: regulation of spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:mah] is_a: GO:0090224 ! regulation of spindle organization relationship: regulates GO:0051231 ! spindle elongation [Term] id: GO:0032888 name: regulation of mitotic spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle." [GOC:mah] is_a: GO:0032887 ! regulation of spindle elongation is_a: GO:0060236 ! regulation of mitotic spindle organization relationship: regulates GO:0000022 ! mitotic spindle elongation [Term] id: GO:0032889 name: regulation of vacuole fusion, non-autophagic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:mah] is_a: GO:0044088 ! regulation of vacuole organization relationship: regulates GO:0042144 ! vacuole fusion, non-autophagic [Term] id: GO:0032890 name: regulation of organic acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0015849 ! organic acid transport [Term] id: GO:0032891 name: negative regulation of organic acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of organic acid transport" EXACT [] synonym: "down-regulation of organic acid transport" EXACT [] synonym: "downregulation of organic acid transport" EXACT [] synonym: "inhibition of organic acid transport" NARROW [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032892 name: positive regulation of organic acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of organic acid transport" NARROW [] synonym: "stimulation of organic acid transport" NARROW [] synonym: "up regulation of organic acid transport" EXACT [] synonym: "up-regulation of organic acid transport" EXACT [] synonym: "upregulation of organic acid transport" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032893 name: regulation of gluconate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of gluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032890 ! regulation of organic acid transport relationship: regulates GO:0015725 ! gluconate transport [Term] id: GO:0032894 name: negative regulation of gluconate transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of gluconate transport" EXACT [] synonym: "down-regulation of gluconate transport" EXACT [] synonym: "downregulation of gluconate transport" EXACT [] synonym: "inhibition of gluconate transport" NARROW [] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0032893 ! regulation of gluconate transport relationship: negatively_regulates GO:0015725 ! gluconate transport [Term] id: GO:0032895 name: positive regulation of gluconate transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of gluconate transport" NARROW [] synonym: "induction of gluconate transport" NARROW [] synonym: "stimulation of gluconate transport" NARROW [] synonym: "up regulation of gluconate transport" EXACT [] synonym: "up-regulation of gluconate transport" EXACT [] synonym: "upregulation of gluconate transport" EXACT [] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0032893 ! regulation of gluconate transport relationship: positively_regulates GO:0015725 ! gluconate transport [Term] id: GO:0032896 name: palmitoyl-CoA 9-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kmv] synonym: "palmitoyl-CoA delta9-desaturase acitivity" EXACT [] is_a: GO:0016215 ! CoA desaturase activity [Term] id: GO:0032897 name: negative regulation of viral transcription namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:mah] synonym: "down regulation of viral transcription" EXACT [] synonym: "down-regulation of viral transcription" EXACT [] synonym: "downregulation of viral transcription" EXACT [] synonym: "inhibition of viral transcription" NARROW [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0046782 ! regulation of viral transcription is_a: GO:0048524 ! positive regulation of viral reproduction is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0019083 ! viral transcription [Term] id: GO:0032898 name: neurotrophin production namespace: biological_process def: "The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth." [GOC:ecd, GOC:mah, GOC:mtg_MIT_16mar07] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0043524 ! negative regulation of neuron apoptosis [Term] id: GO:0032899 name: regulation of neurotrophin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0032898 ! neurotrophin production [Term] id: GO:0032900 name: negative regulation of neurotrophin production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] synonym: "down regulation of neurotrophin production" EXACT [] synonym: "down-regulation of neurotrophin production" EXACT [] synonym: "downregulation of neurotrophin production" EXACT [] synonym: "inhibition of neurotrophin production" NARROW [] is_a: GO:0032899 ! regulation of neurotrophin production is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0032898 ! neurotrophin production [Term] id: GO:0032901 name: positive regulation of neurotrophin production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] synonym: "activation of neurotrophin production" NARROW [] synonym: "stimulation of neurotrophin production" NARROW [] synonym: "up regulation of neurotrophin production" EXACT [] synonym: "up-regulation of neurotrophin production" EXACT [] synonym: "upregulation of neurotrophin production" EXACT [] is_a: GO:0032899 ! regulation of neurotrophin production is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0032898 ! neurotrophin production [Term] id: GO:0032902 name: nerve growth factor production namespace: biological_process def: "The appearance of nerve growth factor due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels." [GOC:ecd, GOC:mah] synonym: "NGF production" EXACT [] is_a: GO:0032898 ! neurotrophin production [Term] id: GO:0032903 name: regulation of nerve growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of nerve growth factor." [GOC:mah] synonym: "regulation of NGF production" EXACT [] is_a: GO:0032899 ! regulation of neurotrophin production relationship: regulates GO:0032902 ! nerve growth factor production [Term] id: GO:0032904 name: negative regulation of nerve growth factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor." [GOC:mah] synonym: "down regulation of nerve growth factor production" EXACT [] synonym: "down-regulation of nerve growth factor production" EXACT [] synonym: "downregulation of nerve growth factor production" EXACT [] synonym: "inhibition of nerve growth factor production" NARROW [] synonym: "negative regulation of NGF production" EXACT [] is_a: GO:0032900 ! negative regulation of neurotrophin production is_a: GO:0032903 ! regulation of nerve growth factor production relationship: negatively_regulates GO:0032902 ! nerve growth factor production [Term] id: GO:0032905 name: transforming growth factor-beta1 production namespace: biological_process def: "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "TGF-B1 production" EXACT [] synonym: "TGFB1 production" EXACT [] is_a: GO:0071604 ! transforming growth factor-beta production [Term] id: GO:0032906 name: transforming growth factor-beta2 production namespace: biological_process def: "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "TGF-B2 production" EXACT [] synonym: "TGFB2 production" EXACT [] is_a: GO:0071604 ! transforming growth factor-beta production [Term] id: GO:0032907 name: transforming growth factor-beta3 production namespace: biological_process def: "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "TGF-B3 production" EXACT [] synonym: "TGFB3 production" EXACT [] is_a: GO:0071604 ! transforming growth factor-beta production [Term] id: GO:0032908 name: regulation of transforming growth factor-beta1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] synonym: "regulation of TGF-B1 production" EXACT [] synonym: "regulation of TGFB1 production" EXACT [] is_a: GO:0071634 ! regulation of transforming growth factor-beta production relationship: regulates GO:0032905 ! transforming growth factor-beta1 production [Term] id: GO:0032909 name: regulation of transforming growth factor-beta2 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] synonym: "regulation of TGF-B2 production" EXACT [] synonym: "regulation of TGFB2 production" EXACT [] is_a: GO:0071634 ! regulation of transforming growth factor-beta production relationship: regulates GO:0032906 ! transforming growth factor-beta2 production [Term] id: GO:0032910 name: regulation of transforming growth factor-beta3 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] synonym: "regulation of TGF-B3 production" EXACT [] synonym: "regulation of TGFB3 production" EXACT [] is_a: GO:0071634 ! regulation of transforming growth factor-beta production relationship: regulates GO:0032907 ! transforming growth factor-beta3 production [Term] id: GO:0032911 name: negative regulation of transforming growth factor-beta1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] synonym: "down regulation of transforming growth factor-beta1 production" EXACT [] synonym: "down-regulation of transforming growth factor-beta1 production" EXACT [] synonym: "downregulation of transforming growth factor-beta1 production" EXACT [] synonym: "inhibition of transforming growth factor-beta1 production" NARROW [] synonym: "negative regulation of TGF-B1 production" EXACT [] synonym: "negative regulation of TGFB1 production" EXACT [] is_a: GO:0032908 ! regulation of transforming growth factor-beta1 production is_a: GO:0071635 ! negative regulation of transforming growth factor-beta production relationship: negatively_regulates GO:0032905 ! transforming growth factor-beta1 production [Term] id: GO:0032912 name: negative regulation of transforming growth factor-beta2 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] synonym: "down regulation of transforming growth factor-beta2 production" EXACT [] synonym: "down-regulation of transforming growth factor-beta2 production" EXACT [] synonym: "downregulation of transforming growth factor-beta2 production" EXACT [] synonym: "inhibition of transforming growth factor-beta2 production" NARROW [] synonym: "negative regulation of TGF-B2 production" EXACT [] synonym: "negative regulation of TGFB2 production" EXACT [] is_a: GO:0032909 ! regulation of transforming growth factor-beta2 production is_a: GO:0071635 ! negative regulation of transforming growth factor-beta production relationship: negatively_regulates GO:0032906 ! transforming growth factor-beta2 production [Term] id: GO:0032913 name: negative regulation of transforming growth factor-beta3 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] synonym: "down regulation of transforming growth factor-beta3 production" EXACT [] synonym: "down-regulation of transforming growth factor-beta3 production" EXACT [] synonym: "downregulation of transforming growth factor-beta3 production" EXACT [] synonym: "inhibition of transforming growth factor-beta3 production" NARROW [] synonym: "negative regulation of TGF-B3 production" EXACT [] synonym: "negative regulation of TGFB3 production" EXACT [] is_a: GO:0032910 ! regulation of transforming growth factor-beta3 production is_a: GO:0071635 ! negative regulation of transforming growth factor-beta production relationship: negatively_regulates GO:0032907 ! transforming growth factor-beta3 production [Term] id: GO:0032914 name: positive regulation of transforming growth factor-beta1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] synonym: "activation of transforming growth factor-beta1 production" NARROW [] synonym: "positive regulation of TGF-B1 production" EXACT [] synonym: "positive regulation of TGFB1 production" EXACT [] synonym: "stimulation of transforming growth factor-beta1 production" NARROW [] synonym: "up regulation of transforming growth factor-beta1 production" EXACT [] synonym: "up-regulation of transforming growth factor-beta1 production" EXACT [] synonym: "upregulation of transforming growth factor-beta1 production" EXACT [] is_a: GO:0032908 ! regulation of transforming growth factor-beta1 production is_a: GO:0071636 ! positive regulation of transforming growth factor-beta production relationship: positively_regulates GO:0032905 ! transforming growth factor-beta1 production [Term] id: GO:0032915 name: positive regulation of transforming growth factor-beta2 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] synonym: "activation of transforming growth factor-beta2 production" NARROW [] synonym: "positive regulation of TGF-B2 production" EXACT [] synonym: "positive regulation of TGFB2 production" EXACT [] synonym: "stimulation of transforming growth factor-beta2 production" NARROW [] synonym: "up regulation of transforming growth factor-beta2 production" EXACT [] synonym: "up-regulation of transforming growth factor-beta2 production" EXACT [] synonym: "upregulation of transforming growth factor-beta2 production" EXACT [] is_a: GO:0032909 ! regulation of transforming growth factor-beta2 production is_a: GO:0071636 ! positive regulation of transforming growth factor-beta production relationship: positively_regulates GO:0032906 ! transforming growth factor-beta2 production [Term] id: GO:0032916 name: positive regulation of transforming growth factor-beta3 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] synonym: "activation of transforming growth factor-beta3 production" NARROW [] synonym: "positive regulation of TGF-B3 production" EXACT [] synonym: "positive regulation of TGFB3 production" EXACT [] synonym: "stimulation of transforming growth factor-beta3 production" NARROW [] synonym: "up regulation of transforming growth factor-beta3 production" EXACT [] synonym: "up-regulation of transforming growth factor-beta3 production" EXACT [] synonym: "upregulation of transforming growth factor-beta3 production" EXACT [] is_a: GO:0032910 ! regulation of transforming growth factor-beta3 production is_a: GO:0071636 ! positive regulation of transforming growth factor-beta production relationship: positively_regulates GO:0032907 ! transforming growth factor-beta3 production [Term] id: GO:0032917 name: polyamine acetylation namespace: biological_process def: "The modification of polyamines by addition of acetyl groups." [GOC:mlg] is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0032918 name: spermidine acetylation namespace: biological_process def: "The modification of spermidine by addition of acetyl groups." [GOC:mlg] is_a: GO:0008216 ! spermidine metabolic process is_a: GO:0032917 ! polyamine acetylation [Term] id: GO:0032919 name: spermine acetylation namespace: biological_process def: "The modification of spermine by addition of acetyl groups." [GOC:mlg] is_a: GO:0008215 ! spermine metabolic process is_a: GO:0032917 ! polyamine acetylation [Term] id: GO:0032920 name: putrescine acetylation namespace: biological_process def: "The modification of putrescine by addition of acetyl groups." [GOC:mlg] is_a: GO:0009445 ! putrescine metabolic process is_a: GO:0032917 ! polyamine acetylation [Term] id: GO:0032921 name: sarcosine oxidase complex namespace: cellular_component def: "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity." [GOC:mah, GOC:mlg] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032922 name: circadian regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] synonym: "circadian regulation of protein expression" RELATED [] synonym: "diurnal variation of gene expression" RELATED [] synonym: "diurnal variation of protein expression" RELATED [] is_a: GO:0007623 ! circadian rhythm is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0032923 name: phosphonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] is_a: GO:0019634 ! phosphonate metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0032924 name: activin receptor signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor." [GOC:rl] synonym: "activin receptor signalling pathway" EXACT [] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0032925 name: regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:rl] synonym: "regulation of activin receptor signalling pathway" EXACT [] synonym: "regulation of activin signaling pathway" RELATED [] synonym: "regulation of activin signalling pathway" RELATED [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032926 name: negative regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:rl] synonym: "down regulation of activin receptor signaling pathway" EXACT [] synonym: "down-regulation of activin receptor signaling pathway" EXACT [] synonym: "downregulation of activin receptor signaling pathway" EXACT [] synonym: "inhibition of activin receptor signaling pathway" NARROW [] synonym: "negative regulation of activin receptor signalling pathway" EXACT [] synonym: "negative regulation of activin signaling pathway" RELATED [] synonym: "negative regulation of activin signalling pathway" RELATED [] is_a: GO:0032925 ! regulation of activin receptor signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032927 name: positive regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:rl] synonym: "activation of activin receptor signaling pathway" NARROW [] synonym: "positive regulation of activin receptor signalling pathway" EXACT [] synonym: "positive regulation of activin signaling pathway" RELATED [] synonym: "positive regulation of activin signalling pathway" RELATED [] synonym: "stimulation of activin receptor signaling pathway" NARROW [] synonym: "up regulation of activin receptor signaling pathway" EXACT [] synonym: "up-regulation of activin receptor signaling pathway" EXACT [] synonym: "upregulation of activin receptor signaling pathway" EXACT [] is_a: GO:0032925 ! regulation of activin receptor signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032928 name: regulation of superoxide anion generation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "regulation of superoxide release" EXACT [GOC:dph, GOC:tb] is_a: GO:0090322 ! regulation of superoxide metabolic process relationship: regulates GO:0042554 ! superoxide anion generation [Term] id: GO:0032929 name: negative regulation of superoxide anion generation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "down regulation of superoxide release" EXACT [] synonym: "down-regulation of superoxide release" EXACT [] synonym: "downregulation of superoxide release" EXACT [] synonym: "inhibition of superoxide release" NARROW [] synonym: "negative regulation of superoxide release" EXACT [GOC:dph, GOC:tb] is_a: GO:0032928 ! regulation of superoxide anion generation is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process relationship: negatively_regulates GO:0042554 ! superoxide anion generation [Term] id: GO:0032930 name: positive regulation of superoxide anion generation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "activation of superoxide release" NARROW [] synonym: "positive regulation of superoxide release" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of superoxide release" NARROW [] synonym: "up regulation of superoxide release" EXACT [] synonym: "up-regulation of superoxide release" EXACT [] synonym: "upregulation of superoxide release" EXACT [] is_a: GO:0032928 ! regulation of superoxide anion generation is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process relationship: positively_regulates GO:0042554 ! superoxide anion generation [Term] id: GO:0032931 name: histone acetyltransferase activity (H3-K56 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K56 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0032932 name: negative regulation of spindle astral microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules." [GOC:mah] synonym: "astral microtubule stabilization" EXACT [] is_a: GO:0007026 ! negative regulation of microtubule depolymerization is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0090224 ! regulation of spindle organization relationship: negatively_regulates GO:0060172 ! spindle astral microtubule depolymerization [Term] id: GO:0032933 name: SREBP-mediated signaling pathway namespace: biological_process def: "A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP." [GOC:mah, PMID:12923525] synonym: "SREBP-mediated signalling pathway" EXACT [] is_a: GO:0006984 ! ER-nucleus signaling pathway [Term] id: GO:0032934 name: sterol binding namespace: molecular_function alt_id: GO:0005498 def: "Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah] subset: gosubset_prok synonym: "sterol carrier activity" RELATED [GOC:mah] is_a: GO:0005496 ! steroid binding [Term] id: GO:0032935 name: sterol sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of a sterol." [GOC:mah] synonym: "sterol-sensing domain" NARROW [] is_a: GO:0032934 ! sterol binding [Term] id: GO:0032936 name: SREBP-SCAP complex namespace: cellular_component def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed." [PMID:12923525] synonym: "Sre1-Scp1 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part [Term] id: GO:0032937 name: SREBP-SCAP-Insig complex namespace: cellular_component def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane." [PMID:12923525] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0030176 ! integral to endoplasmic reticulum membrane [Term] id: GO:0032938 name: negative regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0043556 ! regulation of translation in response to oxidative stress [Term] id: GO:0032939 name: positive regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "activation of translation in response to oxidative stress" NARROW [] synonym: "stimulation of translation in response to oxidative stress" NARROW [] synonym: "up regulation of translation in response to oxidative stress" EXACT [] synonym: "up-regulation of translation in response to oxidative stress" EXACT [] synonym: "upregulation of translation in response to oxidative stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0043556 ! regulation of translation in response to oxidative stress [Term] id: GO:0032940 name: secretion by cell namespace: biological_process def: "The controlled release of a substance by a cell." [GOC:mah] synonym: "cellular secretion" EXACT [] xref: Wikipedia:Secretion is_a: GO:0009987 ! cellular process is_a: GO:0046903 ! secretion is_a: GO:0051649 ! establishment of localization in cell [Term] id: GO:0032941 name: secretion by tissue namespace: biological_process def: "The controlled release of a substance by a tissue." [GOC:mah] synonym: "expulsion of gland contents" RELATED [GOC:mah] synonym: "tissue secretion" EXACT [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0046903 ! secretion [Term] id: GO:0032942 name: inositol tetrakisphosphate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP." [GOC:hf] synonym: "1D-myo-inositol-tetrakisphosphate 2-kinase activity" EXACT [] synonym: "inositol 1,3,4,6-tetrakisphosphate 2-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 2-kinase activity" EXACT [] xref: EC:2.7.1.- is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0032943 name: mononuclear cell proliferation namespace: biological_process def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] synonym: "PBMC proliferation" NARROW [] synonym: "peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070661 ! leukocyte proliferation [Term] id: GO:0032944 name: regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "regulation of PBMC proliferation" NARROW [] synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070663 ! regulation of leukocyte proliferation relationship: regulates GO:0032943 ! mononuclear cell proliferation [Term] id: GO:0032945 name: negative regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "negative regulation of PBMC proliferation" NARROW [] synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070664 ! negative regulation of leukocyte proliferation relationship: negatively_regulates GO:0032943 ! mononuclear cell proliferation [Term] id: GO:0032946 name: positive regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "activation of mononuclear cell proliferation" NARROW [] synonym: "positive regulation of PBMC proliferation" NARROW [] synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW [] synonym: "stimulation of mononuclear cell proliferation" NARROW [] synonym: "up regulation of mononuclear cell proliferation" EXACT [] synonym: "up-regulation of mononuclear cell proliferation" EXACT [] synonym: "upregulation of mononuclear cell proliferation" EXACT [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070665 ! positive regulation of leukocyte proliferation relationship: positively_regulates GO:0032943 ! mononuclear cell proliferation [Term] id: GO:0032947 name: protein complex scaffold namespace: molecular_function def: "Functions to provide a physical support for the assembly of a multiprotein complex." [GOC:mah] is_a: GO:0005198 ! structural molecule activity is_a: GO:0005515 ! protein binding [Term] id: GO:0032948 name: regulation of alpha-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans." [GOC:mah] subset: gosubset_prok synonym: "regulation of alpha-glucan metabolism" EXACT [] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process relationship: regulates GO:0030978 ! alpha-glucan metabolic process [Term] id: GO:0032949 name: regulation of alpha-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans." [GOC:mah] synonym: "regulation of alpha-glucan anabolism" EXACT [] synonym: "regulation of alpha-glucan biosynthesis" EXACT [] synonym: "regulation of alpha-glucan formation" EXACT [] synonym: "regulation of alpha-glucan synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0032948 ! regulation of alpha-glucan metabolic process relationship: regulates GO:0030979 ! alpha-glucan biosynthetic process [Term] id: GO:0032950 name: regulation of beta-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans." [GOC:mah] subset: gosubset_prok synonym: "regulation of beta-glucan metabolism" EXACT [] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process relationship: regulates GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0032951 name: regulation of beta-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans." [GOC:mah] synonym: "regulation of beta-glucan anabolism" EXACT [] synonym: "regulation of beta-glucan biosynthesis" EXACT [] synonym: "regulation of beta-glucan formation" EXACT [] synonym: "regulation of beta-glucan synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0032950 ! regulation of beta-glucan metabolic process relationship: regulates GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0032952 name: regulation of 1,3-beta-D-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-1,3 glucans." [GOC:mah] subset: gosubset_prok synonym: "regulation of 1,3-beta-glucan metabolic process" BROAD [] synonym: "regulation of 1,3-beta-glucan metabolism" EXACT [] is_a: GO:0032950 ! regulation of beta-glucan metabolic process relationship: regulates GO:0006074 ! 1,3-beta-D-glucan metabolic process [Term] id: GO:0032953 name: regulation of 1,3-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta-1,3 glucans." [GOC:mah] synonym: "regulation of 1,3-beta-glucan anabolism" EXACT [] synonym: "regulation of 1,3-beta-glucan biosynthesis" EXACT [] synonym: "regulation of 1,3-beta-glucan biosynthetic process" BROAD [] synonym: "regulation of 1,3-beta-glucan formation" EXACT [] synonym: "regulation of 1,3-beta-glucan synthesis" EXACT [] is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process is_a: GO:0032952 ! regulation of 1,3-beta-D-glucan metabolic process relationship: regulates GO:0006075 ! 1,3-beta-D-glucan biosynthetic process [Term] id: GO:0032954 name: regulation of cytokinetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cytokinetic process." [GOC:mah] subset: gosubset_prok is_a: GO:0032465 ! regulation of cytokinesis relationship: regulates GO:0032506 ! cytokinetic process [Term] id: GO:0032955 name: regulation of barrier septum formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of barrier septum formation. Barrier septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mah] is_a: GO:0032954 ! regulation of cytokinetic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0000917 ! barrier septum formation [Term] id: GO:0032956 name: regulation of actin cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032970 ! regulation of actin filament-based process is_a: GO:0051493 ! regulation of cytoskeleton organization relationship: regulates GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0032957 name: inositol trisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [CHEBI:24540, CHEBI:24848, GOC:mah] synonym: "inositol trisphosphate metabolism" EXACT [] synonym: "IP3 metabolic process" EXACT [] synonym: "IP3 metabolism" EXACT [] synonym: "myo-inositol trisphosphate metabolic process" NARROW [] is_a: GO:0043647 ! inositol phosphate metabolic process [Term] id: GO:0032958 name: inositol phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah] comment: See also the biological process term 'inositol or phosphatidylinositol phosphorylation ; GO:0046853'. synonym: "inositol phosphate anabolism" EXACT [] synonym: "inositol phosphate biosynthesis" EXACT [] synonym: "inositol phosphate formation" EXACT [] synonym: "inositol phosphate synthesis" EXACT [] synonym: "myo-inositol phosphate biosynthetic process" NARROW [] is_a: GO:0043647 ! inositol phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0032959 name: inositol trisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [CHEBI:24848, CHEBI:25450, GOC:mah] synonym: "inositol trisphosphate anabolism" EXACT [] synonym: "inositol trisphosphate biosynthesis" EXACT [] synonym: "inositol trisphosphate formation" EXACT [] synonym: "inositol trisphosphate synthesis" EXACT [] synonym: "IP3 biosynthesis" EXACT [] synonym: "IP3 biosynthetic process" EXACT [] synonym: "myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0032957 ! inositol trisphosphate metabolic process is_a: GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0032960 name: regulation of inositol trisphosphate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] synonym: "regulation of inositol trisphosphate anabolism" EXACT [] synonym: "regulation of inositol trisphosphate biosynthesis" EXACT [] synonym: "regulation of inositol trisphosphate formation" EXACT [] synonym: "regulation of inositol trisphosphate synthesis" EXACT [] synonym: "regulation of IP3 biosynthesis" EXACT [] synonym: "regulation of IP3 biosynthetic process" EXACT [] synonym: "regulation of myo-inositol trisphosphate biosynthesis" NARROW [] synonym: "regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process relationship: regulates GO:0032959 ! inositol trisphosphate biosynthetic process [Term] id: GO:0032961 name: negative regulation of inositol trisphosphate biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] synonym: "negative regulation of inositol trisphosphate anabolism" EXACT [] synonym: "negative regulation of inositol trisphosphate biosynthesis" EXACT [] synonym: "negative regulation of inositol trisphosphate formation" EXACT [] synonym: "negative regulation of inositol trisphosphate synthesis" EXACT [] synonym: "negative regulation of IP3 biosynthesis" EXACT [] synonym: "negative regulation of IP3 biosynthetic process" EXACT [] synonym: "negative regulation of myo-inositol trisphosphate biosynthesis" NARROW [] synonym: "negative regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0010920 ! negative regulation of inositol phosphate biosynthetic process is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process relationship: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process [Term] id: GO:0032962 name: positive regulation of inositol trisphosphate biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] synonym: "positive regulation of inositol trisphosphate anabolism" EXACT [] synonym: "positive regulation of inositol trisphosphate biosynthesis" EXACT [] synonym: "positive regulation of inositol trisphosphate formation" EXACT [] synonym: "positive regulation of inositol trisphosphate synthesis" EXACT [] synonym: "positive regulation of IP3 biosynthesis" EXACT [] synonym: "positive regulation of IP3 biosynthetic process" EXACT [] synonym: "positive regulation of myo-inositol trisphosphate biosynthesis" NARROW [] synonym: "positive regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process is_a: GO:0060732 ! positive regulation of inositol phosphate biosynthetic process relationship: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process [Term] id: GO:0032963 name: collagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "collagen metabolism" EXACT [] is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process [Term] id: GO:0032964 name: collagen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "collagen anabolism" EXACT [] synonym: "collagen biosynthesis" EXACT [] synonym: "collagen formation" EXACT [] synonym: "collagen synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0032963 ! collagen metabolic process [Term] id: GO:0032965 name: regulation of collagen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "regulation of collagen anabolism" EXACT [] synonym: "regulation of collagen biosynthesis" EXACT [] synonym: "regulation of collagen formation" EXACT [] synonym: "regulation of collagen synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010712 ! regulation of collagen metabolic process relationship: regulates GO:0032964 ! collagen biosynthetic process [Term] id: GO:0032966 name: negative regulation of collagen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "negative regulation of collagen anabolism" EXACT [] synonym: "negative regulation of collagen biosynthesis" EXACT [] synonym: "negative regulation of collagen formation" EXACT [] synonym: "negative regulation of collagen synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010713 ! negative regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process relationship: negatively_regulates GO:0032964 ! collagen biosynthetic process [Term] id: GO:0032967 name: positive regulation of collagen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "positive regulation of collagen anabolism" EXACT [] synonym: "positive regulation of collagen biosynthesis" EXACT [] synonym: "positive regulation of collagen formation" EXACT [] synonym: "positive regulation of collagen synthesis" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010714 ! positive regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process relationship: positively_regulates GO:0032964 ! collagen biosynthetic process [Term] id: GO:0032968 name: positive regulation of transcription elongation from RNA polymerase II promoter namespace: biological_process alt_id: GO:0090040 def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "positive regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] synonym: "positive regulation of RNA elongation from RNA polymerase II promoter" EXACT [] is_a: GO:0032786 ! positive regulation of transcription elongation, DNA-dependent is_a: GO:0034243 ! regulation of transcription elongation from RNA polymerase II promoter relationship: positively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter [Term] id: GO:0032969 name: endosomal scaffold complex namespace: cellular_component def: "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling." [PMID:15263099, PMID:16227978, PMID:17496910] synonym: "endosomal adaptor complex" EXACT [GOC:hjd] synonym: "MP1-p14 scaffolding complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0031902 ! late endosome membrane [Term] id: GO:0032970 name: regulation of actin filament-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0030029 ! actin filament-based process [Term] id: GO:0032971 name: regulation of muscle filament sliding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle filament sliding." [GOC:ecd] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0032970 ! regulation of actin filament-based process relationship: regulates GO:0030049 ! muscle filament sliding [Term] id: GO:0032972 name: regulation of muscle filament sliding speed namespace: biological_process def: "Any process that modulates the velocity of muscle filament sliding." [GOC:dph, GOC:ecd, GOC:tb] is_a: GO:0032971 ! regulation of muscle filament sliding is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0032973 name: amino acid export namespace: biological_process def: "The directed movement of amino acids out of a cell or organelle." [GOC:mah] synonym: "amino acid efflux" EXACT [] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0032974 name: amino acid export from vacuole namespace: biological_process def: "The directed movement of amino acids out of the vacuole." [GOC:mah] synonym: "amino acid efflux from vacuole" EXACT [] synonym: "vacuolar amino acid export" EXACT [] is_a: GO:0032973 ! amino acid export is_a: GO:0034487 ! vacuolar amino acid transmembrane transport [Term] id: GO:0032975 name: amino acid import into vacuole namespace: biological_process def: "The directed movement of amino acids into the vacuole." [GOC:mah] synonym: "vacuolar amino acid import" EXACT [] is_a: GO:0034487 ! vacuolar amino acid transmembrane transport is_a: GO:0043090 ! amino acid import [Term] id: GO:0032976 name: release of matrix enzymes from mitochondria namespace: biological_process def: "The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol." [GOC:mah, PMID:9843949] synonym: "mAST release from mitochondria" NARROW [] synonym: "release of aspartate aminotransferase from mitochondria" NARROW [] is_a: GO:0008637 ! apoptotic mitochondrial changes [Term] id: GO:0032977 name: membrane insertase activity namespace: molecular_function def: "Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family." [PMID:14739936] subset: gosubset_prok is_a: GO:0008565 ! protein transporter activity [Term] id: GO:0032978 name: protein insertion into membrane from inner side namespace: biological_process def: "The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side." [PMID:14739936, PMID:15473843] synonym: "insertion of proteins into membrane from the inner side" EXACT [] is_a: GO:0051205 ! protein insertion into membrane [Term] id: GO:0032979 name: protein insertion into mitochondrial membrane from inner side namespace: biological_process def: "The process in which a protein is incorporated into the mitochondrial membrane from the inner side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [PMID:12880202, PMID:15473843] synonym: "insertion of proteins into the mitochondrial membrane from the inner side" EXACT [] is_a: GO:0032978 ! protein insertion into membrane from inner side is_a: GO:0051204 ! protein insertion into mitochondrial membrane [Term] id: GO:0032980 name: keratinocyte activation namespace: biological_process def: "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines." [GOC:mah, PMID:15737202] is_a: GO:0001775 ! cell activation [Term] id: GO:0032981 name: mitochondrial respiratory chain complex I assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph] synonym: "mitochondrial complex I assembly" EXACT [] synonym: "mitochondrial NADH dehydrogenase complex (ubiquinone) assembly" EXACT [] is_a: GO:0010257 ! NADH dehydrogenase complex assembly is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly is_a: GO:0097031 ! mitochondrial respiratory chain complex I biogenesis [Term] id: GO:0032982 name: myosin filament namespace: cellular_component def: "A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah] synonym: "myosin thick filament" RELATED [] synonym: "thick filament" RELATED [] is_a: GO:0016459 ! myosin complex [Term] id: GO:0032983 name: kainate selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluR5-7 and KA-1/2 subunits." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] is_a: GO:0008328 ! ionotropic glutamate receptor complex [Term] id: GO:0032984 name: macromolecular complex disassembly namespace: biological_process def: "The disaggregation of a macromolecular complex into its constituent components." [GOC:mah] subset: gosubset_prok synonym: "macromolecule complex disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0032985 name: protein-carbohydrate complex disassembly namespace: biological_process def: "The disaggregation of a protein-carbohydrate complex into its constituent components." [GOC:mah] is_a: GO:0032984 ! macromolecular complex disassembly is_a: GO:0071823 ! protein-carbohydrate complex subunit organization [Term] id: GO:0032986 name: protein-DNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah] synonym: "DNA-protein complex disassembly" EXACT [GOC:mah] is_a: GO:0034623 ! cellular macromolecular complex disassembly is_a: GO:0071824 ! protein-DNA complex subunit organization [Term] id: GO:0032987 name: protein-lipid complex disassembly namespace: biological_process def: "The disaggregation of a protein-lipid complex into its constituent components." [GOC:mah] is_a: GO:0032984 ! macromolecular complex disassembly is_a: GO:0071825 ! protein-lipid complex subunit organization [Term] id: GO:0032988 name: ribonucleoprotein complex disassembly namespace: biological_process def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] synonym: "protein-RNA complex disassembly" EXACT [] synonym: "RNA-protein complex disassembly" EXACT [] synonym: "RNP complex disassembly" EXACT [] is_a: GO:0034623 ! cellular macromolecular complex disassembly is_a: GO:0071826 ! ribonucleoprotein complex subunit organization [Term] id: GO:0032989 name: cellular component morphogenesis namespace: biological_process def: "The process in which cellular structures, including whole cells or cell parts, are generated and organized." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0016043 ! cellular component organization is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0032990 name: cell part morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell part are generated and organized." [GOC:mah] is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0032991 name: macromolecular complex namespace: cellular_component def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "macromolecule complex" EXACT [] is_a: GO:0005575 ! cellular_component [Term] id: GO:0032992 name: protein-carbohydrate complex namespace: cellular_component def: "A macromolecular complex containing both protein and carbohydrate molecules." [GOC:mah] subset: gosubset_prok is_a: GO:0032991 ! macromolecular complex [Term] id: GO:0032993 name: protein-DNA complex namespace: cellular_component def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] subset: gosubset_prok synonym: "DNA-protein complex" EXACT [GOC:mah] is_a: GO:0032991 ! macromolecular complex [Term] id: GO:0032994 name: protein-lipid complex namespace: cellular_component def: "A macromolecular complex containing both protein and lipid molecules." [GOC:mah] subset: gosubset_prok is_a: GO:0032991 ! macromolecular complex [Term] id: GO:0032995 name: regulation of fungal-type cell wall biogenesis namespace: biological_process def: "Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis" RELATED [GOC:mah] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0009272 ! fungal-type cell wall biogenesis [Term] id: GO:0032996 name: Bcl3-Bcl10 complex namespace: cellular_component def: "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032997 name: Fc receptor complex namespace: cellular_component def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] subset: goslim_pir synonym: "Fc-receptor complex" EXACT [] synonym: "FcR complex" EXACT [] synonym: "immunoglobulin receptor complex" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0032998 name: Fc-epsilon receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "FceRI complex" EXACT [] synonym: "IgE receptor complex" BROAD [] synonym: "immunoglobulin E receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0032999 name: Fc-alpha receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12524384] synonym: "FcaRI complex" EXACT [] synonym: "IgA receptor complex" BROAD [] synonym: "immunoglobulin A receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033000 name: Fc-gamma receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11244038, PMID:12413532] synonym: "FcgRI complex" EXACT [] synonym: "IgG receptor complex" BROAD [] synonym: "immunoglobulin G receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033001 name: Fc-gamma receptor III complex namespace: cellular_component def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11244038, PMID:12413532] synonym: "FcgRIII complex" EXACT [] synonym: "IgG receptor complex" BROAD [] synonym: "immunoglobulin G receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033002 name: muscle cell proliferation namespace: biological_process def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] synonym: "myocyte proliferation" EXACT [] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0033003 name: regulation of mast cell activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002694 ! regulation of leukocyte activation relationship: regulates GO:0045576 ! mast cell activation [Term] id: GO:0033004 name: negative regulation of mast cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0033003 ! regulation of mast cell activation relationship: negatively_regulates GO:0045576 ! mast cell activation [Term] id: GO:0033005 name: positive regulation of mast cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0033003 ! regulation of mast cell activation relationship: positively_regulates GO:0045576 ! mast cell activation [Term] id: GO:0033006 name: regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0033003 ! regulation of mast cell activation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002279 ! mast cell activation involved in immune response [Term] id: GO:0033007 name: negative regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "negative regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0033004 ! negative regulation of mast cell activation is_a: GO:0033006 ! regulation of mast cell activation involved in immune response relationship: negatively_regulates GO:0002279 ! mast cell activation involved in immune response [Term] id: GO:0033008 name: positive regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "positive regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0033005 ! positive regulation of mast cell activation is_a: GO:0033006 ! regulation of mast cell activation involved in immune response relationship: positively_regulates GO:0002279 ! mast cell activation involved in immune response [Term] id: GO:0033009 name: nucleomorph namespace: cellular_component def: "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively." [PMID:16760254] xref: Wikipedia:Nucleomorph is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044435 ! plastid part [Term] id: GO:0033010 name: paranodal junction namespace: cellular_component def: "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [PMID:11395001, PMID:14630217] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0033011 name: perinuclear theca namespace: cellular_component def: "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins." [PMID:17289678, PMID:8025156] is_a: GO:0005856 ! cytoskeleton is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0048471 ! perinuclear region of cytoplasm [Term] id: GO:0033012 name: porosome namespace: cellular_component def: "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles." [PMID:15090256, PMID:16563225] xref: Wikipedia:Porosome is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0033013 name: tetrapyrrole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah] synonym: "tetrapyrrole metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0033014 name: tetrapyrrole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah] synonym: "tetrapyrrole anabolism" EXACT [] synonym: "tetrapyrrole biosynthesis" EXACT [] synonym: "tetrapyrrole formation" EXACT [] synonym: "tetrapyrrole synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0033015 name: tetrapyrrole catabolic process namespace: biological_process def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah] synonym: "tetrapyrrole breakdown" EXACT [] synonym: "tetrapyrrole catabolism" EXACT [] synonym: "tetrapyrrole degradation" EXACT [] is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0033016 name: rhoptry membrane namespace: cellular_component def: "The lipid bilayer surrounding a rhoptry." [GOC:mah] is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0020008 ! rhoptry [Term] id: GO:0033017 name: sarcoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph] is_a: GO:0005789 ! endoplasmic reticulum membrane relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0033018 name: sarcoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph] is_a: GO:0005788 ! endoplasmic reticulum lumen relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0033019 name: 5-hydroxyvalerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH." [GOC:mlg, PMID:12406764] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033020 name: cyclopentanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclopentanol." [GOC:mlg, PMID:12406764] subset: gosubset_prok synonym: "cyclopentanol metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0033021 name: cyclopentanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyclopentanol." [GOC:mah, PMID:12406764] subset: gosubset_prok synonym: "cyclopentanol anabolism" EXACT [] synonym: "cyclopentanol biosynthesis" EXACT [] synonym: "cyclopentanol formation" EXACT [] synonym: "cyclopentanol synthesis" EXACT [] is_a: GO:0033020 ! cyclopentanol metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0033022 name: cyclopentanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclopentanol." [GOC:mah, PMID:12406764] subset: gosubset_prok synonym: "cyclopentanol breakdown" EXACT [] synonym: "cyclopentanol catabolism" EXACT [] synonym: "cyclopentanol degradation" EXACT [] is_a: GO:0033020 ! cyclopentanol metabolic process is_a: GO:0034310 ! primary alcohol catabolic process [Term] id: GO:0033023 name: mast cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:11292031] comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0033024 name: mast cell apoptosis namespace: biological_process def: "The process of apoptosis in mast cells." [GOC:add, PMID:11292031, PMID:12360215, PMID:16605130] synonym: "apoptosis of mast cells" EXACT [] is_a: GO:0033028 ! myeloid cell apoptosis relationship: part_of GO:0033023 ! mast cell homeostasis [Term] id: GO:0033025 name: regulation of mast cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell apoptosis." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0033032 ! regulation of myeloid cell apoptosis relationship: regulates GO:0033024 ! mast cell apoptosis [Term] id: GO:0033026 name: negative regulation of mast cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a mast cell apoptosis." [GOC:add] synonym: "down regulation of mast cell apoptosis" EXACT [] synonym: "down-regulation of mast cell apoptosis" EXACT [] synonym: "downregulation of mast cell apoptosis" EXACT [] synonym: "inhibition of mast cell apoptosis" NARROW [] is_a: GO:0033025 ! regulation of mast cell apoptosis is_a: GO:0033033 ! negative regulation of myeloid cell apoptosis relationship: negatively_regulates GO:0033024 ! mast cell apoptosis [Term] id: GO:0033027 name: positive regulation of mast cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell apoptosis." [GOC:add] synonym: "activation of mast cell apoptosis" NARROW [] synonym: "stimulation of mast cell apoptosis" NARROW [] synonym: "up regulation of mast cell apoptosis" EXACT [] synonym: "up-regulation of mast cell apoptosis" EXACT [] synonym: "upregulation of mast cell apoptosis" EXACT [] is_a: GO:0033025 ! regulation of mast cell apoptosis is_a: GO:0033034 ! positive regulation of myeloid cell apoptosis relationship: positively_regulates GO:0033024 ! mast cell apoptosis [Term] id: GO:0033028 name: myeloid cell apoptosis namespace: biological_process def: "The process of apoptosis in myeloid cells." [GOC:add, PMID:11292031, PMID:15330259, PMID:17133093] synonym: "apoptosis of myeloid cells" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0033029 name: regulation of neutrophil apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil apoptosis." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0033032 ! regulation of myeloid cell apoptosis relationship: regulates GO:0001781 ! neutrophil apoptosis [Term] id: GO:0033030 name: negative regulation of neutrophil apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a neutrophil apoptosis." [GOC:add] synonym: "down regulation of neutrophil apoptosis" EXACT [] synonym: "down-regulation of neutrophil apoptosis" EXACT [] synonym: "downregulation of neutrophil apoptosis" EXACT [] synonym: "inhibition of neutrophil apoptosis" NARROW [] is_a: GO:0033029 ! regulation of neutrophil apoptosis is_a: GO:0033033 ! negative regulation of myeloid cell apoptosis relationship: negatively_regulates GO:0001781 ! neutrophil apoptosis [Term] id: GO:0033031 name: positive regulation of neutrophil apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptosis." [GOC:add] synonym: "activation of neutrophil apoptosis" NARROW [] synonym: "stimulation of neutrophil apoptosis" NARROW [] synonym: "up regulation of neutrophil apoptosis" EXACT [] synonym: "up-regulation of neutrophil apoptosis" EXACT [] synonym: "upregulation of neutrophil apoptosis" EXACT [] is_a: GO:0033029 ! regulation of neutrophil apoptosis is_a: GO:0033034 ! positive regulation of myeloid cell apoptosis relationship: positively_regulates GO:0001781 ! neutrophil apoptosis [Term] id: GO:0033032 name: regulation of myeloid cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptosis." [GOC:add] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0033028 ! myeloid cell apoptosis [Term] id: GO:0033033 name: negative regulation of myeloid cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptosis." [GOC:add] synonym: "down regulation of myeloid cell apoptosis" EXACT [] synonym: "down-regulation of myeloid cell apoptosis" EXACT [] synonym: "downregulation of myeloid cell apoptosis" EXACT [] synonym: "inhibition of myeloid cell apoptosis" NARROW [] is_a: GO:0033032 ! regulation of myeloid cell apoptosis is_a: GO:0043066 ! negative regulation of apoptosis relationship: negatively_regulates GO:0033028 ! myeloid cell apoptosis [Term] id: GO:0033034 name: positive regulation of myeloid cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptosis." [GOC:add] synonym: "activation of myeloid cell apoptosis" NARROW [] synonym: "stimulation of myeloid cell apoptosis" NARROW [] synonym: "up regulation of myeloid cell apoptosis" EXACT [] synonym: "up-regulation of myeloid cell apoptosis" EXACT [] synonym: "upregulation of myeloid cell apoptosis" EXACT [] is_a: GO:0033032 ! regulation of myeloid cell apoptosis is_a: GO:0043065 ! positive regulation of apoptosis relationship: positively_regulates GO:0033028 ! myeloid cell apoptosis [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: gosubset_prok synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0033037 name: polysaccharide localization namespace: biological_process def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah] subset: gosubset_prok synonym: "polysaccharide localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0033038 name: bitter taste receptor activity namespace: molecular_function def: "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity [Term] id: GO:0033039 name: salty taste receptor activity namespace: molecular_function def: "Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity [Term] id: GO:0033040 name: sour taste receptor activity namespace: molecular_function def: "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity [Term] id: GO:0033041 name: sweet taste receptor activity namespace: molecular_function def: "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity [Term] id: GO:0033042 name: umami taste receptor activity namespace: molecular_function def: "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates." [GOC:mah] is_a: GO:0008527 ! taste receptor activity [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0006996 ! organelle organization [Term] id: GO:0033044 name: regulation of chromosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0051276 ! chromosome organization [Term] id: GO:0033045 name: regulation of sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation relationship: regulates GO:0000819 ! sister chromatid segregation [Term] id: GO:0033046 name: negative regulation of sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:0051985 ! negative regulation of chromosome segregation relationship: negatively_regulates GO:0000819 ! sister chromatid segregation [Term] id: GO:0033047 name: regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0007088 ! regulation of mitosis is_a: GO:0033045 ! regulation of sister chromatid segregation relationship: regulates GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0033048 name: negative regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033046 ! negative regulation of sister chromatid segregation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0033049 name: clavulanic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [CHEBI:3736, GOC:mah] synonym: "clavulanic acid metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0033050 name: clavulanic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [CHEBI:3736, GOC:mah] synonym: "clavulanic acid anabolism" EXACT [] synonym: "clavulanic acid biosynthesis" EXACT [] synonym: "clavulanic acid formation" EXACT [] synonym: "clavulanic acid synthesis" EXACT [] xref: Wikipedia:Clavulanic_acid is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0033049 ! clavulanic acid metabolic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0033051 name: aminophosphonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah, http://pages.unibas.ch/mdpi/ecsoc/a0045/a0045.htm, KEGG_PATHWAY:map00440] synonym: "aminophosphonate metabolism" EXACT [] is_a: GO:0019634 ! phosphonate metabolic process [Term] id: GO:0033052 name: cyanoamino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group." [GOC:mah, PMID:11575729] synonym: "cyanoamino acid metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0033053 name: D-glutamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid." [CHEBI:17061, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-glutamine metabolism" EXACT [] is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033054 name: D-glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid." [CHEBI:15966, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-glutamate metabolism" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033055 name: D-arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:15816, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-arginine metabolism" EXACT [] is_a: GO:0006525 ! arginine metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033056 name: D-ornithine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid." [CHEBI:16176, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-ornithine metabolism" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033057 name: multicellular organismal reproductive behavior namespace: biological_process def: "The specific actions or reactions of an organism that are associated with reproduction in a multicellular organism." [GOC:mtg_MIT_16mar07] synonym: "reproductive behavior in a multicellular organism" EXACT [GOC:curators] is_a: GO:0019098 ! reproductive behavior is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0033058 name: directional locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another along an axis." [GOC:mtg_MIT_16mar07] is_a: GO:0040011 ! locomotion [Term] id: GO:0033059 name: cellular pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] subset: gosubset_prok is_a: GO:0009987 ! cellular process is_a: GO:0043473 ! pigmentation [Term] id: GO:0033060 name: ocellus pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates." [GOC:mtg_MIT_16mar07] is_a: GO:0043473 ! pigmentation [Term] id: GO:0033061 name: DNA recombinase mediator complex namespace: cellular_component def: "A protein complex that promotes nucleoprotein filament formation during homologous recombination; most known examples contain two or more RecA family proteins (often Rad51 paralogs)." [GOC:elh, GOC:mah, GOC:vw] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0033062 name: Rhp55-Rhp57 complex namespace: cellular_component def: "A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces)." [GOC:mah, GOC:vw] synonym: "Rad55-Rad57 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex [Term] id: GO:0033063 name: Rad51B-Rad51C-Rad51D-XRCC2 complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "BCDX2 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex [Term] id: GO:0033064 name: XRCC2-RAD51D complex namespace: cellular_component def: "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast." [GOC:mah, GOC:vw, PMID:16093548] synonym: "DX2 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex [Term] id: GO:0033065 name: Rad51C-XRCC3 complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "CX3 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex [Term] id: GO:0033066 name: Rad51B-Rad51C complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "BC complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex [Term] id: GO:0033067 name: macrolide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:17298179] subset: gosubset_prok synonym: "macrolide metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0033068 name: macrolide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:17298179] subset: gosubset_prok synonym: "macrolide anabolism" EXACT [] synonym: "macrolide biosynthesis" EXACT [] synonym: "macrolide formation" EXACT [] synonym: "macrolide synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0033067 ! macrolide metabolic process [Term] id: GO:0033069 name: ansamycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] subset: gosubset_prok synonym: "ansamycin metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0034311 ! diol metabolic process [Term] id: GO:0033070 name: ansamycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] subset: gosubset_prok synonym: "ansamycin anabolism" EXACT [] synonym: "ansamycin biosynthesis" EXACT [] synonym: "ansamycin formation" EXACT [] synonym: "ansamycin synthesis" EXACT [] is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0033069 ! ansamycin metabolic process [Term] id: GO:0033071 name: vancomycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [CHEBI:28001, GOC:mah] subset: gosubset_prok synonym: "vancomycin metabolism" EXACT [] is_a: GO:0030650 ! peptide antibiotic metabolic process [Term] id: GO:0033072 name: vancomycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [CHEBI:28001, GOC:mah] subset: gosubset_prok synonym: "vancomycin anabolism" EXACT [] synonym: "vancomycin biosynthesis" EXACT [] synonym: "vancomycin formation" EXACT [] synonym: "vancomycin synthesis" EXACT [] is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0030651 ! peptide antibiotic biosynthetic process is_a: GO:0033071 ! vancomycin metabolic process [Term] id: GO:0033073 name: pinene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html] subset: gosubset_prok synonym: "pinene metabolism" EXACT [] is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0043692 ! monoterpene metabolic process [Term] id: GO:0033074 name: pinene catabolic process namespace: biological_process def: "The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html] synonym: "pinene breakdown" EXACT [] synonym: "pinene catabolism" EXACT [] synonym: "pinene degradation" EXACT [] is_a: GO:0016100 ! monoterpenoid catabolic process is_a: GO:0033073 ! pinene metabolic process [Term] id: GO:0033075 name: isoquinoline alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] subset: gosubset_prok synonym: "ipecac alkaloid biosynthesis" RELATED [] synonym: "isoquinoline alkaloid anabolism" EXACT [] synonym: "isoquinoline alkaloid biosynthesis" EXACT [] synonym: "isoquinoline alkaloid formation" EXACT [] synonym: "isoquinoline alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0033076 ! isoquinoline alkaloid metabolic process [Term] id: GO:0033076 name: isoquinoline alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] subset: gosubset_prok synonym: "ipecac alkaloid metabolism" RELATED [] synonym: "isoquinoline alkaloid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0033077 name: T cell differentiation in thymus namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development in thymus" RELATED [GOC:add] synonym: "thymic T cell differentiation" EXACT [] synonym: "thymocyte cell differentiation" EXACT [] synonym: "thymocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0033078 name: extrathymic T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "extrathymic T cell development" RELATED [GOC:add] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0033079 name: immature T cell proliferation namespace: biological_process def: "The expansion of an immature T cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0042098 ! T cell proliferation [Term] id: GO:0033080 name: immature T cell proliferation in thymus namespace: biological_process def: "The expansion of an immature T cell population by cell division in the thymus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "thymic T cell proliferation" EXACT [] synonym: "thymocyte cell proliferation" EXACT [] synonym: "thymocyte proliferation" EXACT [] is_a: GO:0033079 ! immature T cell proliferation relationship: part_of GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033081 name: regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T cell development in thymus" RELATED [GOC:add] synonym: "regulation of thymic T cell differentiation" EXACT [] synonym: "regulation of thymocyte cell differentiation" EXACT [] synonym: "regulation of thymocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation relationship: regulates GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033082 name: regulation of extrathymic T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of extrathymic T cell development" RELATED [GOC:add] is_a: GO:0045580 ! regulation of T cell differentiation relationship: regulates GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0033083 name: regulation of immature T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0042129 ! regulation of T cell proliferation relationship: regulates GO:0033079 ! immature T cell proliferation [Term] id: GO:0033084 name: regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of thymic T cell proliferation" EXACT [] synonym: "regulation of thymocyte cell proliferation" EXACT [] synonym: "regulation of thymocyte proliferation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0033083 ! regulation of immature T cell proliferation relationship: regulates GO:0033080 ! immature T cell proliferation in thymus [Term] id: GO:0033085 name: negative regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "negative regulation of T cell development in thymus" RELATED [GOC:add] synonym: "negative regulation of thymic T cell differentiation" EXACT [] synonym: "negative regulation of thymocyte cell differentiation" EXACT [] synonym: "negative regulation of thymocyte differentiation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0045581 ! negative regulation of T cell differentiation relationship: negatively_regulates GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033086 name: negative regulation of extrathymic T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "negative regulation of extrathymic T cell development" RELATED [GOC:add] is_a: GO:0033082 ! regulation of extrathymic T cell differentiation is_a: GO:0045581 ! negative regulation of T cell differentiation relationship: negatively_regulates GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0033087 name: negative regulation of immature T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0033083 ! regulation of immature T cell proliferation is_a: GO:0042130 ! negative regulation of T cell proliferation relationship: negatively_regulates GO:0033079 ! immature T cell proliferation [Term] id: GO:0033088 name: negative regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] synonym: "negative regulation of thymic T cell proliferation" EXACT [] synonym: "negative regulation of thymocyte cell proliferation" EXACT [] synonym: "negative regulation of thymocyte proliferation" EXACT [] is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus is_a: GO:0033087 ! negative regulation of immature T cell proliferation relationship: negatively_regulates GO:0033080 ! immature T cell proliferation in thymus [Term] id: GO:0033089 name: positive regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "positive regulation of T cell development in thymus" RELATED [GOC:add] synonym: "positive regulation of thymic T cell differentiation" EXACT [] synonym: "positive regulation of thymocyte cell differentiation" EXACT [] synonym: "positive regulation of thymocyte differentiation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0045582 ! positive regulation of T cell differentiation relationship: positively_regulates GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033090 name: positive regulation of extrathymic T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "positive regulation of extrathymic T cell development" RELATED [GOC:add] is_a: GO:0033082 ! regulation of extrathymic T cell differentiation is_a: GO:0045582 ! positive regulation of T cell differentiation relationship: positively_regulates GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0033091 name: positive regulation of immature T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0033083 ! regulation of immature T cell proliferation is_a: GO:0042102 ! positive regulation of T cell proliferation relationship: positively_regulates GO:0033079 ! immature T cell proliferation [Term] id: GO:0033092 name: positive regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] synonym: "positive regulation of thymic T cell proliferation" EXACT [] synonym: "positive regulation of thymocyte cell proliferation" EXACT [] synonym: "positive regulation of thymocyte proliferation" EXACT [] is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus is_a: GO:0033091 ! positive regulation of immature T cell proliferation relationship: positively_regulates GO:0033080 ! immature T cell proliferation in thymus [Term] id: GO:0033093 name: Weibel-Palade body namespace: cellular_component def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708] xref: Wikipedia:Weibel-Palade_body is_a: GO:0030136 ! clathrin-coated vesicle is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0033094 name: butane-1,4-diamine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O." [EC:2.6.1.82, GOC:mlg] synonym: "PAT activity" RELATED [] synonym: "putrescine aminotransferase activity" BROAD [EC:2.6.1.82] synonym: "putrescine transaminase activity" BROAD [] synonym: "putrescine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.82] synonym: "putrescine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] synonym: "YgjG" RELATED [EC:2.6.1.82] xref: EC:2.6.1.82 xref: MetaCyc:2.6.1.82-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033095 name: aleurone grain namespace: cellular_component def: "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes." [http://ejournal.sinica.edu.tw/bbas/content/2004/1/bot451-08.pdf, http://www.springerlink.com/content/q7183h5vr7358278/] synonym: "aleurone body" EXACT [] is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0033096 name: amyloplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0033097 name: amyloplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope." [GOC:ecd] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0033096 ! amyloplast envelope [Term] id: GO:0033098 name: amyloplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma." [GOC:ecd] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0033097 ! amyloplast membrane [Term] id: GO:0033099 name: attachment organelle namespace: cellular_component def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [http://authors.library.caltech.edu/3529/, PMID:11325545, PMID:12003948] subset: goslim_pir is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0033100 name: NuA3 histone acetyltransferase complex namespace: cellular_component def: "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p." [PMID:10817755, PMID:17157260] is_a: GO:0070775 ! H3 histone acetyltransferase complex [Term] id: GO:0033101 name: cellular bud membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cellular bud." [GOC:mah] synonym: "cellular bud plasma membrane" EXACT [] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0033102 name: acidocalcisome membrane namespace: cellular_component def: "The lipid bilayer surrounding an acidocalcisome." [GOC:ecd, PMID:11378195] is_a: GO:0031090 ! organelle membrane is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0020022 ! acidocalcisome [Term] id: GO:0033103 name: protein secretion by the type VI secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'. synonym: "protein secretion by the T6SS" EXACT [] synonym: "protein secretion by the type VI protein secretion system" EXACT [] synonym: "type VI protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0033104 name: type VI protein secretion system complex namespace: cellular_component def: "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] subset: gosubset_prok synonym: "T6SS complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0033105 name: chlorosome envelope namespace: cellular_component def: "The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome." [PMID:14507718, PMID:14729689, PMID:17303128] comment: Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'. synonym: "chlorosome membrane" EXACT [] is_a: GO:0034646 ! organelle-enclosing lipid monolayer relationship: part_of GO:0046858 ! chlorosome [Term] id: GO:0033106 name: cis-Golgi network membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." [GOC:mah] synonym: "cis Golgi network membrane" EXACT [] synonym: "Golgi cis face membrane" RELATED [] is_a: GO:0000139 ! Golgi membrane relationship: part_of GO:0005801 ! cis-Golgi network [Term] id: GO:0033107 name: CVT vesicle namespace: cellular_component def: "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p)." [GOC:rb, PMID:15138258] is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0033108 name: mitochondrial respiratory chain complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007005 ! mitochondrion organization [Term] id: GO:0033109 name: cortical actin cytoskeleton stabilization namespace: biological_process def: "The process in which the assembly and arrangement of cytoskeletal structures in the actin cortex with respect to the plasma membrane is maintained." [GOC:mah, GOC:pf] synonym: "actin cortex stabilization" EXACT [] synonym: "cortical resistance" RELATED [] is_a: GO:0030866 ! cortical actin cytoskeleton organization [Term] id: GO:0033110 name: CVT vesicle membrane namespace: cellular_component def: "The double lipid bilayer surrounding a CVT vesicle." [GOC:ecd] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0033107 ! CVT vesicle [Term] id: GO:0033111 name: attachment organelle membrane namespace: cellular_component def: "The lipid bilayer surrounding an attachment organelle." [GOC:ecd] is_a: GO:0031090 ! organelle membrane is_a: GO:0044424 ! intracellular part relationship: part_of GO:0033099 ! attachment organelle [Term] id: GO:0033112 name: cyanelle envelope namespace: cellular_component def: "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0033113 name: cyanelle membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope." [GOC:ecd] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0033112 ! cyanelle envelope [Term] id: GO:0033114 name: cyanelle thylakoid lumen namespace: cellular_component def: "The volume enclosed by a cyanelle thylakoid membrane." [GOC:mah] is_a: GO:0031978 ! plastid thylakoid lumen relationship: part_of GO:0009843 ! cyanelle thylakoid [Term] id: GO:0033115 name: cyanelle thylakoid membrane namespace: cellular_component def: "The lipid bilayer membrane of any thylakoid within a cyanelle." [GOC:mah] is_a: GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0009843 ! cyanelle thylakoid [Term] id: GO:0033116 name: ER-Golgi intermediate compartment membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the ER-Golgi intermediate compartment system." [GOC:mah, PMID:16723730] is_a: GO:0031090 ! organelle membrane is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0005793 ! ER-Golgi intermediate compartment [Term] id: GO:0033117 name: esterosome namespace: cellular_component def: "A vesicle filled with crystalline protein that shows sequence similarities with various esterases." [GOC:ecd, PMID:2307702] is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0033118 name: esterosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes." [GOC:ecd, PMID:2307702] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0033117 ! esterosome [Term] id: GO:0033119 name: negative regulation of RNA splicing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah] is_a: GO:0043484 ! regulation of RNA splicing is_a: GO:0051253 ! negative regulation of RNA metabolic process relationship: negatively_regulates GO:0008380 ! RNA splicing [Term] id: GO:0033120 name: positive regulation of RNA splicing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah] is_a: GO:0043484 ! regulation of RNA splicing is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0008380 ! RNA splicing [Term] id: GO:0033121 name: regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "regulation of purine nucleotide breakdown" EXACT [] synonym: "regulation of purine nucleotide catabolism" EXACT [] synonym: "regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process relationship: regulates GO:0006195 ! purine nucleotide catabolic process [Term] id: GO:0033122 name: negative regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "negative regulation of purine nucleotide breakdown" EXACT [] synonym: "negative regulation of purine nucleotide catabolism" EXACT [] synonym: "negative regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030812 ! negative regulation of nucleotide catabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process relationship: negatively_regulates GO:0006195 ! purine nucleotide catabolic process [Term] id: GO:0033123 name: positive regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "positive regulation of purine nucleotide breakdown" EXACT [] synonym: "positive regulation of purine nucleotide catabolism" EXACT [] synonym: "positive regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030813 ! positive regulation of nucleotide catabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process relationship: positively_regulates GO:0006195 ! purine nucleotide catabolic process [Term] id: GO:0033124 name: regulation of GTP catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] synonym: "regulation of GTP breakdown" EXACT [] synonym: "regulation of GTP catabolism" EXACT [] synonym: "regulation of GTP degradation" EXACT [] is_a: GO:0033121 ! regulation of purine nucleotide catabolic process relationship: regulates GO:0006184 ! GTP catabolic process [Term] id: GO:0033125 name: negative regulation of GTP catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] synonym: "negative regulation of GTP breakdown" EXACT [] synonym: "negative regulation of GTP catabolism" EXACT [] synonym: "negative regulation of GTP degradation" EXACT [] is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process is_a: GO:0033124 ! regulation of GTP catabolic process relationship: negatively_regulates GO:0006184 ! GTP catabolic process [Term] id: GO:0033126 name: positive regulation of GTP catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] synonym: "positive regulation of GTP breakdown" EXACT [] synonym: "positive regulation of GTP catabolism" EXACT [] synonym: "positive regulation of GTP degradation" EXACT [] is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process is_a: GO:0033124 ! regulation of GTP catabolic process relationship: positively_regulates GO:0006184 ! GTP catabolic process [Term] id: GO:0033127 name: regulation of histone phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031056 ! regulation of histone modification relationship: regulates GO:0016572 ! histone phosphorylation [Term] id: GO:0033128 name: negative regulation of histone phosphorylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0033127 ! regulation of histone phosphorylation relationship: negatively_regulates GO:0016572 ! histone phosphorylation [Term] id: GO:0033129 name: positive regulation of histone phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0033127 ! regulation of histone phosphorylation relationship: positively_regulates GO:0016572 ! histone phosphorylation [Term] id: GO:0033130 name: acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an acetylcholine receptor." [GOC:mah] is_a: GO:0005102 ! receptor binding [Term] id: GO:0033131 name: regulation of glucokinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] synonym: "glucokinase regulator" NARROW [] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0043549 ! regulation of kinase activity [Term] id: GO:0033132 name: negative regulation of glucokinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] synonym: "down regulation of glucokinase activity" EXACT [] synonym: "down-regulation of glucokinase activity" EXACT [] synonym: "downregulation of glucokinase activity" EXACT [] synonym: "glucokinase inhibitor" NARROW [] synonym: "inhibition of glucokinase activity" NARROW [] is_a: GO:0033131 ! regulation of glucokinase activity is_a: GO:0033673 ! negative regulation of kinase activity [Term] id: GO:0033133 name: positive regulation of glucokinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] synonym: "glucokinase activator" NARROW [] synonym: "stimulation of glucokinase activity" NARROW [] synonym: "up regulation of glucokinase activity" EXACT [] synonym: "up-regulation of glucokinase activity" EXACT [] synonym: "upregulation of glucokinase activity" EXACT [] is_a: GO:0033131 ! regulation of glucokinase activity is_a: GO:0033674 ! positive regulation of kinase activity [Term] id: GO:0033134 name: ubiquitin activating enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin activating enzyme, any of the E1 proteins." [GOC:mah] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0033135 name: regulation of peptidyl-serine phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] subset: gosubset_prok is_a: GO:0001932 ! regulation of protein phosphorylation relationship: regulates GO:0018105 ! peptidyl-serine phosphorylation [Term] id: GO:0033136 name: serine phosphorylation of STAT3 protein namespace: biological_process def: "The process of introducing a phosphate group to a serine residue of the STAT3 protein." [GOC:jl, GOC:mah] is_a: GO:0042501 ! serine phosphorylation of STAT protein [Term] id: GO:0033137 name: negative regulation of peptidyl-serine phosphorylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation relationship: negatively_regulates GO:0018105 ! peptidyl-serine phosphorylation [Term] id: GO:0033138 name: positive regulation of peptidyl-serine phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation relationship: positively_regulates GO:0018105 ! peptidyl-serine phosphorylation [Term] id: GO:0033139 name: regulation of peptidyl-serine phosphorylation of STAT protein namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation relationship: part_of GO:0042501 ! serine phosphorylation of STAT protein [Term] id: GO:0033140 name: negative regulation of peptidyl-serine phosphorylation of STAT protein namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] is_a: GO:0033137 ! negative regulation of peptidyl-serine phosphorylation is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein [Term] id: GO:0033141 name: positive regulation of peptidyl-serine phosphorylation of STAT protein namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] is_a: GO:0033138 ! positive regulation of peptidyl-serine phosphorylation is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein [Term] id: GO:0033142 name: progesterone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a progesterone receptor." [GOC:mah] is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0033143 name: regulation of steroid hormone receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of any steroid hormone receptor signaling pathway." [GOC:mah] synonym: "regulation of steroid hormone receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0030518 ! steroid hormone receptor signaling pathway [Term] id: GO:0033144 name: negative regulation of steroid hormone receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any steroid hormone receptor signaling pathway." [GOC:mah] synonym: "negative regulation of steroid hormone receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway relationship: negatively_regulates GO:0030518 ! steroid hormone receptor signaling pathway [Term] id: GO:0033145 name: positive regulation of steroid hormone receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of any steroid hormone receptor signaling pathway." [GOC:mah] synonym: "positive regulation of steroid hormone receptor signalling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway relationship: positively_regulates GO:0030518 ! steroid hormone receptor signaling pathway [Term] id: GO:0033146 name: regulation of estrogen receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GOC:mah] synonym: "regulation of estrogen receptor signalling pathway" EXACT [] is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway relationship: regulates GO:0030520 ! estrogen receptor signaling pathway [Term] id: GO:0033147 name: negative regulation of estrogen receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GOC:mah] synonym: "negative regulation of estrogen receptor signalling pathway" EXACT [] is_a: GO:0033144 ! negative regulation of steroid hormone receptor signaling pathway is_a: GO:0033146 ! regulation of estrogen receptor signaling pathway relationship: negatively_regulates GO:0030520 ! estrogen receptor signaling pathway [Term] id: GO:0033148 name: positive regulation of estrogen receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GOC:mah] synonym: "positive regulation of estrogen receptor signalling pathway" EXACT [] is_a: GO:0033145 ! positive regulation of steroid hormone receptor signaling pathway is_a: GO:0033146 ! regulation of estrogen receptor signaling pathway relationship: positively_regulates GO:0030520 ! estrogen receptor signaling pathway [Term] id: GO:0033149 name: FFAT motif binding namespace: molecular_function def: "Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family." [PMID:12727870, PMID:15455074, PMID:16004875] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0033150 name: cytoskeletal calyx namespace: cellular_component def: "A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins." [PMID:12243744, PMID:9184090] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0033011 ! perinuclear theca [Term] id: GO:0033151 name: V(D)J recombination namespace: biological_process def: "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221, ISBN:0781735149 "Fundamental Immunology"] synonym: "V(D)J joining" EXACT [] synonym: "V-D-J joining" EXACT [] synonym: "V-D-J recombination" EXACT [] synonym: "V-J joining" EXACT [] synonym: "V-J recombination" EXACT [] xref: Wikipedia:V(D)J_recombination is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus [Term] id: GO:0033152 name: immunoglobulin V(D)J recombination namespace: biological_process def: "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "immunoglobulin V(D)J joining" EXACT [GOC:add] synonym: "immunoglobulin V-D-J joining" NARROW [GOC:add] synonym: "immunoglobulin V-D-J recombination" NARROW [GOC:add] synonym: "immunoglobulin V-J joining" NARROW [GOC:add] synonym: "immunoglobulin V-J recombination" NARROW [GOC:add] is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments is_a: GO:0033151 ! V(D)J recombination [Term] id: GO:0033153 name: T cell receptor V(D)J recombination namespace: biological_process def: "The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221] synonym: "T cell receptor V(D)J joining" EXACT [GOC:add] synonym: "T cell receptor V-D-J joining" NARROW [GOC:add] synonym: "T cell receptor V-D-J recombination" NARROW [GOC:add] synonym: "T cell receptor V-J joining" NARROW [GOC:add] synonym: "T cell receptor V-J recombination" NARROW [GOC:add] synonym: "T-cell receptor V(D)J recombination" EXACT [GOC:add] synonym: "TCR V(D)J recombination" EXACT [GOC:add] is_a: GO:0002681 ! somatic recombination of T cell receptor gene segments is_a: GO:0033151 ! V(D)J recombination [Term] id: GO:0033154 name: oligogalacturonide transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)." [GOC:mlg] is_a: GO:0015422 ! oligosaccharide-transporting ATPase activity is_a: GO:0015478 ! oligosaccharide transporting porin activity is_a: GO:0033155 ! oligogalacturonide transmembrane transporter activity [Term] id: GO:0033155 name: oligogalacturonide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oligogalacturonide from one side of the membrane to the other." [GOC:mlg] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity [Term] id: GO:0033156 name: oligogalacturonide transport namespace: biological_process def: "The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] is_a: GO:0015772 ! oligosaccharide transport [Term] id: GO:0033157 name: regulation of intracellular protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051223 ! regulation of protein transport relationship: regulates GO:0006886 ! intracellular protein transport [Term] id: GO:0033158 name: regulation of protein import into nucleus, translocation namespace: biological_process def: "Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] synonym: "regulation of protein import into cell nucleus, translocation" EXACT [] is_a: GO:0042306 ! regulation of protein import into nucleus relationship: regulates GO:0000060 ! protein import into nucleus, translocation [Term] id: GO:0033159 name: negative regulation of protein import into nucleus, translocation namespace: biological_process def: "Any process that stops, prevents or reduces the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] synonym: "negative regulation of protein import into cell nucleus, translocation" EXACT [] is_a: GO:0033158 ! regulation of protein import into nucleus, translocation is_a: GO:0090317 ! negative regulation of intracellular protein transport relationship: negatively_regulates GO:0000060 ! protein import into nucleus, translocation [Term] id: GO:0033160 name: positive regulation of protein import into nucleus, translocation namespace: biological_process def: "Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] synonym: "positive regulation of protein import into cell nucleus, translocation" EXACT [] is_a: GO:0033158 ! regulation of protein import into nucleus, translocation is_a: GO:0090316 ! positive regulation of intracellular protein transport relationship: positively_regulates GO:0000060 ! protein import into nucleus, translocation [Term] id: GO:0033161 name: mitogen-activated protein kinase kinase kinase kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase kinase." [GOC:mah] synonym: "MAPKKKK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0033162 name: melanosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a melanosome." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0042470 ! melanosome relationship: part_of GO:0045009 ! chitosome [Term] id: GO:0033163 name: microneme membrane namespace: cellular_component def: "The lipid bilayer surrounding a microneme." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044424 ! intracellular part relationship: part_of GO:0020009 ! microneme [Term] id: GO:0033164 name: glycolipid 6-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,6-D-mannosyl-D-mannose linkage." [EC:2.4.1.232, GOC:mcc, PMID:16878994] synonym: "GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232] synonym: "GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232] synonym: "initiation-specific alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.232] xref: EC:2.4.1.232 xref: MetaCyc:2.4.1.232-RXN is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0033165 name: interphotoreceptor matrix namespace: cellular_component def: "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance." [http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html, PMID:1862095, PMID:2194288] is_a: GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0033166 name: hyaline layer namespace: cellular_component def: "A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms." [http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html, PMID:1721506, PMID:9473317] is_a: GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0033167 name: ARC complex namespace: cellular_component def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA." [GOC:vw, PMID:17310250] synonym: "argonaute siRNA chaperone complex" EXACT [] is_a: GO:0031332 ! RNAi effector complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0033168 name: conversion of ds siRNA to ss siRNA involved in RNA interference namespace: biological_process def: "The process in which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference." [GOC:mah, PMID:17310250] synonym: "RNA interference, conversion of ds siRNA to ss siRNA" EXACT [GOC:mah] is_a: GO:0006396 ! RNA processing relationship: part_of GO:0030422 ! production of siRNA involved in RNA interference [Term] id: GO:0033169 name: histone H3-K9 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone." [GOC:mah] is_a: GO:0070076 ! histone lysine demethylation [Term] id: GO:0033170 name: protein-DNA loading ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the assembly of a protein or protein complex onto a DNA molecule." [GOC:mah, GOC:vw] synonym: "DNA-protein loading ATPase activity" EXACT [GOC:mah] is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0033171 name: nucleoprotein filament-forming ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of proteins such as Rad51p onto single-stranded (ss) DNA to form a helical nucleoprotein filament." [GOC:mah, GOC:vw] comment: This term was made obsolete because nucleoprotein filament formation does not require ATP hydrolysis, so the term is misleading. is_obsolete: true [Term] id: GO:0033172 name: gas vesicle shell namespace: cellular_component def: "The proteinaceous structure surrounding a gas vesicle." [GOC:ecd] synonym: "gas vesicle membrane" RELATED [] synonym: "gas vesicle wall" EXACT [] is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0031411 ! gas vesicle [Term] id: GO:0033173 name: calcineurin-NFAT signaling pathway namespace: biological_process def: "A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin." [GOC:lm, GOC:mah, PMID:15928679] synonym: "calcineurin-NFAT signalling pathway" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0048016 ! inositol phosphate-mediated signaling [Term] id: GO:0033174 name: chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits." [GOC:mah, GOC:pj, PMID:11032839] synonym: "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)" EXACT [] is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex [Term] id: GO:0033175 name: chloroplast proton-transporting ATP synthase complex, coupling factor CF(o) namespace: cellular_component def: "All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins." [GOC:mah] synonym: "chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)" EXACT [] synonym: "chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)" EXACT [] is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex [Term] id: GO:0033176 name: proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553] synonym: "hydrogen-translocating V-type ATPase complex" EXACT [] is_a: GO:0016469 ! proton-transporting two-sector ATPase complex [Term] id: GO:0033177 name: proton-transporting two-sector ATPase complex, proton-transporting domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex [Term] id: GO:0033178 name: proton-transporting two-sector ATPase complex, catalytic domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex [Term] id: GO:0033179 name: proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex [Term] id: GO:0033180 name: proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553] is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex [Term] id: GO:0033181 name: plasma membrane proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase" EXACT [] is_a: GO:0033176 ! proton-transporting V-type ATPase complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0033182 name: regulation of histone ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031396 ! regulation of protein ubiquitination relationship: regulates GO:0016574 ! histone ubiquitination [Term] id: GO:0033183 name: negative regulation of histone ubiquitination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0031397 ! negative regulation of protein ubiquitination is_a: GO:0033182 ! regulation of histone ubiquitination relationship: negatively_regulates GO:0016574 ! histone ubiquitination [Term] id: GO:0033184 name: positive regulation of histone ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0031398 ! positive regulation of protein ubiquitination is_a: GO:0033182 ! regulation of histone ubiquitination relationship: positively_regulates GO:0016574 ! histone ubiquitination [Term] id: GO:0033185 name: dolichol-phosphate-mannose synthase complex namespace: cellular_component def: "A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346] synonym: "dolichyl-phosphate beta-D-mannosyltransferase complex" EXACT [] synonym: "DPM synthase complex" EXACT [] is_a: GO:0031501 ! mannosyltransferase complex [Term] id: GO:0033186 name: CAF-1 complex namespace: cellular_component def: "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276] synonym: "chromatin assembly factor 1 complex" EXACT [] is_a: GO:0005678 ! chromatin assembly complex [Term] id: GO:0033187 name: inositol hexakisphosphate 4-kinase or 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [PMID:17412958, PMID:17412959] is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0033188 name: sphingomyelin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin." [EC:2.7.8.27, RHEA:18768] synonym: "ceramide:phosphatidylcholine cholinephosphotransferase activity" EXACT [EC:2.7.8.27] synonym: "phosphatidylcholine:ceramide cholinephosphotransferase activity" EXACT [EC:2.7.8.27] synonym: "SM synthase activity" EXACT [EC:2.7.8.27] synonym: "SMS1" RELATED [EC:2.7.8.27] synonym: "SMS2" RELATED [EC:2.7.8.27] xref: EC:2.7.8.27 xref: KEGG:R08969 xref: MetaCyc:2.7.8.27-RXN xref: Reactome:260950 "sphingomyelin synthase activity" xref: RHEA:18768 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0033189 name: response to vitamin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:sl] synonym: "response to retinol" NARROW [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0033190 name: solanapyrone synthase activity namespace: molecular_function def: "Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A." [GOC:cb, PMID:9659400] is_a: GO:0009975 ! cyclase activity [Term] id: GO:0033191 name: macrophomate synthase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate." [CHEBI:38228, GOC:cb, PMID:10984474] is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0033192 name: calmodulin-dependent protein phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118] synonym: "Ca2+/CaM-dependent protein phosphatase activity" RELATED [] synonym: "calcineurin activity" NARROW [] synonym: "calcium- and calmodulin-dependent protein phosphatase activity" EXACT [] synonym: "calcium/calmodulin-dependent protein phosphatase activity" EXACT [] is_a: GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity [Term] id: GO:0033193 name: Lsd1/2 complex namespace: cellular_component def: "A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast." [GOC:vw, PMID:17371846, PMID:17434129, PMID:17440621] synonym: "SAPHIRE complex" EXACT [PMID:17371846] synonym: "Swm complex" EXACT [PMID:17440621] synonym: "Swm1/2 complex" RELATED [PMID:17440621] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0033194 name: response to hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [CHEBI:35923, GOC:mah] subset: gosubset_prok is_a: GO:0006979 ! response to oxidative stress [Term] id: GO:0033195 name: response to alkyl hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [CHEBI:35923, GOC:mah] is_a: GO:0033194 ! response to hydroperoxide [Term] id: GO:0033196 name: tryparedoxin peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O." [GOC:mah] synonym: "TXNPx activity" EXACT [] xref: MetaCyc:1.11.1.15-RXN is_a: GO:0004601 ! peroxidase activity is_a: GO:0051920 ! peroxiredoxin activity [Term] id: GO:0033197 name: response to vitamin E namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:sl] synonym: "response to DL-alpha-tocopherol acetate" NARROW [] synonym: "response to DL-alpha-tocopheryl acetate" NARROW [] synonym: "response to O-Acetyl-alpha-tocopherol" NARROW [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0033198 name: response to ATP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl] synonym: "response to adenosine 5'-triphosphate" EXACT [] synonym: "response to adenosine triphosphate" EXACT [] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0033199 name: inositol heptakisphosphate 4-kinase or 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] is_a: GO:0000829 ! inositol heptakisphosphate kinase activity [Term] id: GO:0033200 name: inositol heptakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] synonym: "diphosphoinositol-pentakisphosphate 5-kinase activity" EXACT [] synonym: "IP7 5-kinase activity" EXACT [] is_a: GO:0000829 ! inositol heptakisphosphate kinase activity [Term] id: GO:0033201 name: alpha-1,4-glucan synthase activity namespace: molecular_function def: "Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP." [PMID:17472966] synonym: "1,4-alpha-glucan synthase activity" EXACT [] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0033202 name: DNA helicase complex namespace: cellular_component def: "A protein complex that possesses DNA helicase activity." [GOC:mah] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0033203 name: DNA helicase A complex namespace: cellular_component def: "A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction." [PMID:9341218] is_a: GO:0033202 ! DNA helicase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0033204 name: ribonuclease P RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963] synonym: "RNase P RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0033205 name: cell cycle cytokinesis namespace: biological_process def: "Cytokinesis that occurs in the context of cell cycle progression and results in the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0000910 ! cytokinesis is_a: GO:0022402 ! cell cycle process [Term] id: GO:0033206 name: cytokinesis after meiosis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mah] is_a: GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0033207 name: beta-1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage." [GOC:mah] synonym: "beta-1,4-GalNAc transferase activity" EXACT [] is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0033208 name: UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide." [GOC:mah, PMID:12678917, PMID:16024623] synonym: "Sda beta 1,4GalNAc transferase" RELATED [] synonym: "UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] is_a: GO:0033207 ! beta-1,4-N-acetylgalactosaminyltransferase activity [Term] id: GO:0033209 name: tumor necrosis factor-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:mah] synonym: "adipocytokine signaling pathway" RELATED [] synonym: "TNF-alpha-mediated signaling pathway" EXACT [] synonym: "tumor necrosis factor alpha-mediated signaling pathway" EXACT [] synonym: "tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway is_a: GO:0071356 ! cellular response to tumor necrosis factor [Term] id: GO:0033210 name: leptin-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor." [GOC:mah] synonym: "adipocytokine signaling pathway" RELATED [] synonym: "leptin-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0033211 name: adiponectin-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of adiponectin binding to a cell surface receptor." [GOC:mah] synonym: "adipocytokine signaling pathway" RELATED [] synonym: "adiponectin-mediated signalling pathway" EXACT [] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0033212 name: iron assimilation namespace: biological_process def: "A process in which iron is solubilized and transported into a cell." [GOC:mah] is_a: GO:0006879 ! cellular iron ion homeostasis [Term] id: GO:0033213 name: iron assimilation by capture and transport namespace: biological_process def: "A process in which iron (Fe3+) is solubilized by binding to a receptor or transport protein and transported into a cell." [GOC:mah] is_a: GO:0033212 ! iron assimilation [Term] id: GO:0033214 name: iron assimilation by chelation and transport namespace: biological_process def: "A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors." [GOC:mah, PMID:16963626] is_a: GO:0033212 ! iron assimilation [Term] id: GO:0033215 name: iron assimilation by reduction and transport namespace: biological_process def: "A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins." [GOC:mah, PMID:16963626] is_a: GO:0033212 ! iron assimilation [Term] id: GO:0033216 name: ferric iron import namespace: biological_process def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into a cell or organelle." [GOC:mah] synonym: "ferric ion import" EXACT [] synonym: "ferric iron uptake" EXACT [] is_a: GO:0015682 ! ferric iron transport [Term] id: GO:0033217 name: regulation of transcription from RNA polymerase II promoter in response to iron ion starvation namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of iron ions." [GOC:mah] synonym: "regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [] is_a: GO:0010106 ! cellular response to iron ion starvation is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress [Term] id: GO:0033218 name: amide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988, GOC:mah] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0033219 name: urea binding namespace: molecular_function def: "Interacting selectively and non-covalently with urea, a water-soluble carboxamide with the structure H2N-CO-NH2." [CHEBI:16199, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0033218 ! amide binding [Term] id: GO:0033220 name: amide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in)." [GOC:mah] subset: gosubset_prok is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances is_a: GO:0042887 ! amide transmembrane transporter activity [Term] id: GO:0033221 name: urea-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)." [GOC:mlg] subset: gosubset_prok synonym: "carbamide-transporting ATPase activity" EXACT [] is_a: GO:0015204 ! urea transmembrane transporter activity is_a: GO:0033220 ! amide-transporting ATPase activity [Term] id: GO:0033222 name: xylose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of xylose." [CHEBI:18222, GOC:mah] subset: gosubset_prok is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0033223 name: 2-aminoethylphosphonate transport namespace: biological_process def: "The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] synonym: "2-phosphonoethylamine transport" EXACT [] synonym: "ciliatine transport" EXACT [] is_a: GO:0015716 ! phosphonate transport is_a: GO:0015837 ! amine transport [Term] id: GO:0033224 name: 2-aminoethylphosphonate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of 2-aminoethylphosphonate into, out of or within a cell, or between cells." [GOC:mlg] synonym: "2-phosphonoethylamine transmembrane transporter activity" EXACT [] synonym: "ciliatine transporter activity" EXACT [] is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0033225 name: 2-aminoethylphosphonate transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)." [GOC:mlg] synonym: "2-phosphonoethylamine transporting ATPase activity" EXACT [] synonym: "ciliatine transportingATPase activity" EXACT [] is_a: GO:0031263 ! amine-transporting ATPase activity is_a: GO:0033224 ! 2-aminoethylphosphonate transmembrane transporter activity [Term] id: GO:0033226 name: 2-aminoethylphosphonate binding namespace: molecular_function def: "Interacting selectively and non-covalently with 2-aminoethylphosphonate." [GOC:mlg] synonym: "2-phosphonoethylamine binding" EXACT [] synonym: "ciliatine binding" EXACT [] is_a: GO:0043176 ! amine binding [Term] id: GO:0033227 name: dsRNA transport namespace: biological_process def: "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0050658 ! RNA transport [Term] id: GO:0033228 name: cysteine export namespace: biological_process def: "The directed movement of cysteine out of a cell or organelle." [GOC:mlg] is_a: GO:0032973 ! amino acid export is_a: GO:0042883 ! cysteine transport [Term] id: GO:0033229 name: cysteine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cysteine from one side of the membrane to the other." [GOC:mah] is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0033230 name: cysteine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)." [GOC:mlg] is_a: GO:0015424 ! amino acid-transporting ATPase activity is_a: GO:0033229 ! cysteine transmembrane transporter activity [Term] id: GO:0033231 name: carbohydrate export namespace: biological_process def: "The directed movement of carbohydrates out of a cell or organelle." [GOC:mlg] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0033232 name: D-methionine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)." [GOC:mlg] is_a: GO:0015424 ! amino acid-transporting ATPase activity is_a: GO:0048474 ! D-methionine transmembrane transporter activity [Term] id: GO:0033233 name: regulation of protein sumoylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah] synonym: "regulation of sumoylation" EXACT [] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0016925 ! protein sumoylation [Term] id: GO:0033234 name: negative regulation of protein sumoylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah] synonym: "negative regulation of sumoylation" EXACT [] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0033233 ! regulation of protein sumoylation relationship: negatively_regulates GO:0016925 ! protein sumoylation [Term] id: GO:0033235 name: positive regulation of protein sumoylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah] synonym: "positive regulation of sumoylation" EXACT [] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0033233 ! regulation of protein sumoylation relationship: positively_regulates GO:0016925 ! protein sumoylation [Term] id: GO:0033236 name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036] is_obsolete: true replaced_by: GO:0070523 [Term] id: GO:0033237 name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146] synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146] xref: EC:1.1.1.146 xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN is_obsolete: true replaced_by: GO:0070524 [Term] id: GO:0033238 name: regulation of cellular amine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah] subset: gosubset_prok synonym: "regulation of amine metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: regulates GO:0044106 ! cellular amine metabolic process [Term] id: GO:0033239 name: negative regulation of cellular amine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "negative regulation of amine metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process relationship: negatively_regulates GO:0044106 ! cellular amine metabolic process [Term] id: GO:0033240 name: positive regulation of cellular amine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "positive regulation of amine metabolism" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process relationship: positively_regulates GO:0044106 ! cellular amine metabolic process [Term] id: GO:0033241 name: regulation of cellular amine catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "regulation of amine breakdown" EXACT [] synonym: "regulation of amine catabolism" EXACT [] synonym: "regulation of amine degradation" EXACT [] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process relationship: regulates GO:0009310 ! amine catabolic process [Term] id: GO:0033242 name: negative regulation of cellular amine catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "negative regulation of amine breakdown" EXACT [] synonym: "negative regulation of amine catabolism" EXACT [] synonym: "negative regulation of amine degradation" EXACT [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0033241 ! regulation of cellular amine catabolic process relationship: negatively_regulates GO:0009310 ! amine catabolic process [Term] id: GO:0033243 name: positive regulation of cellular amine catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "positive regulation of amine breakdown" EXACT [] synonym: "positive regulation of amine catabolism" EXACT [] synonym: "positive regulation of amine degradation" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0033241 ! regulation of cellular amine catabolic process relationship: positively_regulates GO:0009310 ! amine catabolic process [Term] id: GO:0033244 name: regulation of penicillin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "regulation of penicillin metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process relationship: regulates GO:0042316 ! penicillin metabolic process [Term] id: GO:0033245 name: negative regulation of penicillin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "negative regulation of penicillin metabolism" EXACT [] is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0033244 ! regulation of penicillin metabolic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process relationship: negatively_regulates GO:0042316 ! penicillin metabolic process [Term] id: GO:0033246 name: positive regulation of penicillin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "positive regulation of penicillin metabolism" EXACT [] is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0033244 ! regulation of penicillin metabolic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process relationship: positively_regulates GO:0042316 ! penicillin metabolic process [Term] id: GO:0033247 name: regulation of penicillin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "regulation of penicillin breakdown" EXACT [] synonym: "regulation of penicillin catabolism" EXACT [] synonym: "regulation of penicillin degradation" EXACT [] is_a: GO:0033244 ! regulation of penicillin metabolic process is_a: GO:0034251 ! regulation of cellular amide catabolic process relationship: regulates GO:0042317 ! penicillin catabolic process [Term] id: GO:0033248 name: negative regulation of penicillin catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "negative regulation of penicillin breakdown" EXACT [] synonym: "negative regulation of penicillin catabolism" EXACT [] synonym: "negative regulation of penicillin degradation" EXACT [] is_a: GO:0033245 ! negative regulation of penicillin metabolic process is_a: GO:0033247 ! regulation of penicillin catabolic process is_a: GO:0034252 ! negative regulation of cellular amide catabolic process relationship: negatively_regulates GO:0042317 ! penicillin catabolic process [Term] id: GO:0033249 name: positive regulation of penicillin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "positive regulation of penicillin breakdown" EXACT [] synonym: "positive regulation of penicillin catabolism" EXACT [] synonym: "positive regulation of penicillin degradation" EXACT [] is_a: GO:0033246 ! positive regulation of penicillin metabolic process is_a: GO:0033247 ! regulation of penicillin catabolic process is_a: GO:0034253 ! positive regulation of cellular amide catabolic process relationship: positively_regulates GO:0042317 ! penicillin catabolic process [Term] id: GO:0033250 name: penicillinase activity namespace: molecular_function def: "Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin." [GOC:mlg] xref: MetaCyc:BETA-LACTAMASE-RXN is_a: GO:0008800 ! beta-lactamase activity [Term] id: GO:0033251 name: cephalosporinase activity namespace: molecular_function def: "Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin." [GOC:mlg] xref: MetaCyc:BETA-LACTAMASE-RXN is_a: GO:0008800 ! beta-lactamase activity [Term] id: GO:0033252 name: regulation of beta-lactamase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid." [GOC:mah] is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0033253 name: regulation of penicillinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of a penicillin to yield a substituted beta-amino acid derivative." [GOC:mah] is_a: GO:0033252 ! regulation of beta-lactamase activity [Term] id: GO:0033254 name: vacuolar transporter chaperone complex namespace: cellular_component def: "A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p." [PMID:11823419, PMID:17079729] synonym: "VTC complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0033255 name: SAS acetyltransferase complex namespace: cellular_component def: "A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p." [PMID:11731480, PMID:12626510, PMID:15788653] synonym: "SAS-I complex" EXACT [] is_a: GO:0032777 ! Piccolo NuA4 histone acetyltransferase complex [Term] id: GO:0033256 name: I-kappaB/NF-kappaB complex namespace: cellular_component def: "A protein complex containing an I-kappaB protein and one or more copies of an NF-kappaB protein; mediates regulation of NF-kappaB activity by I-kappaB." [GOC:mah, PMID:9407099] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0033257 name: Bcl3/NF-kappaB2 complex namespace: cellular_component def: "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] synonym: "Bcl3-NFKB2 complex" RELATED [] synonym: "Bcl3-p52 complex" EXACT [] is_a: GO:0033256 ! I-kappaB/NF-kappaB complex [Term] id: GO:0033258 name: plastid DNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving plastid DNA." [GOC:mah] synonym: "plastid DNA metabolism" EXACT [] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0009657 ! plastid organization [Term] id: GO:0033259 name: plastid DNA replication namespace: biological_process def: "The process in which new strands of DNA are synthesized in a plastid." [GOC:mah] synonym: "plastid DNA synthesis" RELATED [] synonym: "replication of plastid DNA" EXACT [] is_a: GO:0006261 ! DNA-dependent DNA replication is_a: GO:0033258 ! plastid DNA metabolic process [Term] id: GO:0033260 name: DNA replication involved in S phase namespace: biological_process def: "The process in which new strands of genomic DNA are synthesized, using parental DNA as a template for DNA-dependent DNA polymerases, contributing to progression through S phase of the cell cycle." [GOC:mah] synonym: "DNA replication during S phase" RELATED [GOC:dph, GOC:tb] synonym: "DNA replication involved in S-phase" EXACT [] is_a: GO:0006261 ! DNA-dependent DNA replication relationship: part_of GO:0051320 ! S phase [Term] id: GO:0033261 name: regulation of S phase namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of progression through S phase" EXACT [GOC:dph, GOC:tb] synonym: "regulation of S-phase" EXACT [] xref: MetaCyc:PWY-5043 xref: MetaCyc:SALVADEHYPOX-PWY xref: MetaCyc:SALVPURINE2-PWY is_a: GO:0010564 ! regulation of cell cycle process relationship: regulates GO:0051320 ! S phase [Term] id: GO:0033262 name: regulation of DNA replication involved in S phase namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication that contributes to the progression through S phase of the cell cycle." [GOC:mah] synonym: "regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb] synonym: "regulation of DNA replication involved in S-phase" EXACT [] is_a: GO:0033261 ! regulation of S phase is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: regulates GO:0033260 ! DNA replication involved in S phase [Term] id: GO:0033263 name: CORVET complex namespace: cellular_component def: "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625] is_a: GO:0043234 ! protein complex is_a: GO:0044440 ! endosomal part [Term] id: GO:0033264 name: bontoxilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." [EC:3.4.24.69] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "BoNT" RELATED [EC:3.4.24.69] synonym: "botulinum neurotoxin activity" EXACT [] xref: EC:3.4.24.69 xref: MetaCyc:3.4.24.69-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0033265 name: choline binding namespace: molecular_function def: "Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [CHEBI:15354, GOC:mlg] is_a: GO:0043169 ! cation binding is_a: GO:0043176 ! amine binding is_a: GO:0043178 ! alcohol binding is_a: GO:0050997 ! quaternary ammonium group binding [Term] id: GO:0033266 name: choline-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane." [GOC:mlg] is_a: GO:0015220 ! choline transmembrane transporter activity is_a: GO:0031263 ! amine-transporting ATPase activity [Term] id: GO:0033267 name: axon part namespace: cellular_component def: "A part of an axon, a cell projection of a neuron." [GOC:jl] xref: NIF_Subcellular:sao280355188 is_a: GO:0044463 ! cell projection part relationship: part_of GO:0030424 ! axon [Term] id: GO:0033268 name: node of Ranvier namespace: cellular_component def: "An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed." [GOC:mh] xref: NIF_Subcellular:birnlex_1152_2 xref: Wikipedia:Nodes_of_Ranvier is_a: GO:0033267 ! axon part relationship: part_of GO:0044304 ! main axon [Term] id: GO:0033269 name: internode region of axon namespace: cellular_component def: "An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath." [GOC:mah, GOC:mh] synonym: "internode" EXACT [] xref: NIF_Subcellular:sao206157942 is_a: GO:0033267 ! axon part relationship: part_of GO:0044304 ! main axon [Term] id: GO:0033270 name: paranode region of axon namespace: cellular_component def: "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath." [GOC:mah, GOC:mh] synonym: "paranode" EXACT [] xref: NIF_Subcellular:sao234066064 is_a: GO:0033267 ! axon part relationship: part_of GO:0044304 ! main axon [Term] id: GO:0033271 name: myo-inositol phosphate transport namespace: biological_process def: "The directed movement of any phosphorylated myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015798 ! myo-inositol transport [Term] id: GO:0033272 name: myo-inositol hexakisphosphate transport namespace: biological_process def: "The directed movement of myo-inositol hexakisphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17401, GOC:mah] synonym: "phytate transport" EXACT [] is_a: GO:0033271 ! myo-inositol phosphate transport [Term] id: GO:0033273 name: response to vitamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:sl] is_a: GO:0007584 ! response to nutrient [Term] id: GO:0033274 name: response to vitamin B2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:sl] synonym: "response to riboflavin" EXACT [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0033275 name: actin-myosin filament sliding namespace: biological_process def: "The sliding movement of actin thin filaments and myosin thick filaments past each other." [GOC:pf] synonym: "actin filament sliding" RELATED [] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0070252 ! actin-mediated cell contraction [Term] id: GO:0033276 name: transcription factor TFTC complex namespace: cellular_component def: "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity." [PMID:10373431, PMID:9603525] is_a: GO:0005667 ! transcription factor complex is_a: GO:0070461 ! SAGA-type complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0033277 name: abortive mitotic cell cycle namespace: biological_process def: "A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy." [GOC:mah, PMID:9573008] comment: Note that this term should be used only for abortive mitotic events that occur normally, e.g. during megakaryocyte differentiation; it should not be used for incomplete mitosis resulting from mutation or other abnormal occurrences. Note that this term should not be confused with 'endomitotic cell cycle ; GO:0007113', which describes a process in which no mitotic spindle forms. synonym: "abortive mitosis" RELATED [] is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0033278 name: cell proliferation in midbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf] comment: This term was added by GO_REF:0000021. synonym: "cell proliferation in mesencephalon" EXACT [] synonym: "mesencepahalic cell proliferation" RELATED [] is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0030901 ! midbrain development [Term] id: GO:0033280 name: response to vitamin D namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:sl] synonym: "response to calciferol" EXACT [] synonym: "response to cholecalciferol" NARROW [] synonym: "response to ergocalciferol" NARROW [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0033281 name: TAT protein transport complex namespace: cellular_component def: "A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins." [GOC:pamgo_curators] subset: gosubset_prok synonym: "TAT protein secretion complex" NARROW [] synonym: "TAT protein translocation system complex" NARROW [] synonym: "Twin-arginine translocation complex " NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0033282 name: protein C inhibitor-acrosin complex namespace: cellular_component def: "A heterodimeric protein complex of protein C inhibitor and acrosin; complex formation inhibits the protease activity of acrosin." [PMID:11120760, PMID:7521127] synonym: "PCI-ACR complex" EXACT [] synonym: "PCI-acrosin complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0033283 name: organic acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)." [GOC:mlg] is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0033284 name: carboxylic acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)." [GOC:mlg] is_a: GO:0033283 ! organic acid-transporting ATPase activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0033285 name: monocarboxylic acid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)." [GOC:mlg] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0033284 ! carboxylic acid-transporting ATPase activity [Term] id: GO:0033286 name: ectoine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)." [GOC:mlg] is_a: GO:0033285 ! monocarboxylic acid-transporting ATPase activity is_a: GO:0051471 ! ectoine transmembrane transporter activity [Term] id: GO:0033287 name: hydroxyectoine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of hydroxyectoine from one side of the membrane to the other." [GOC:mlg] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0033288 name: hydroxyectoine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)." [GOC:mlg] is_a: GO:0033285 ! monocarboxylic acid-transporting ATPase activity is_a: GO:0033287 ! hydroxyectoine transmembrane transporter activity [Term] id: GO:0033289 name: intraconoid microtubule namespace: cellular_component def: "A microtubule located such that it threads through the conoid and projects through the polar ring." [GOC:mah, PMID:11901169, PMID:16518471] is_a: GO:0005874 ! microtubule relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0033290 name: eukaryotic 48S preinitiation complex namespace: cellular_component alt_id: GO:0016283 def: "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049] synonym: "eukaryotic 48S initiation complex" RELATED [] synonym: "eukaryotic 48S pre-initiation complex" EXACT [] is_a: GO:0070993 ! translation preinitiation complex [Term] id: GO:0033291 name: eukaryotic 80S initiation complex namespace: cellular_component def: "A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region." [GOC:hjd, PMID:15145049] is_a: GO:0070992 ! translation initiation complex [Term] id: GO:0033292 name: T-tubule organization namespace: biological_process def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:dph, GOC:jl, GOC:mah] synonym: "T-tubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0007009 ! plasma membrane organization relationship: part_of GO:0055001 ! muscle cell development [Term] id: GO:0033293 name: monocarboxylic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah] subset: gosubset_prok is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0033294 name: ectoine binding namespace: molecular_function def: "Interacting selectively and non-covalently with ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid." [GOC:mah] is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0033295 name: hydroxyectoine binding namespace: molecular_function def: "Interacting selectively and non-covalently with hydroxyectoine." [GOC:mlg] is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0033296 name: rhamnose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of rhamnose." [CHEBI:26546, GOC:mah] subset: gosubset_prok is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0033297 name: rhamnose-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + rhamnose(out/in) = ADP + phosphate + rhamnose(in/out)." [GOC:mlg] is_a: GO:0015153 ! rhamnose transmembrane transporter activity is_a: GO:0015407 ! monosaccharide-transporting ATPase activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0033298 name: contractile vacuole organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores." [GOC:mah] synonym: "contractile vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007033 ! vacuole organization is_a: GO:0016050 ! vesicle organization [Term] id: GO:0033299 name: secretion of lysosomal enzymes namespace: biological_process def: "The controlled release of lysosomal enzymes by a cell or group of cells." [GOC:mah] is_a: GO:0009306 ! protein secretion [Term] id: GO:0033300 name: dehydroascorbic acid transporter activity namespace: molecular_function def: "Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17242] synonym: "dehydroascorbate transporter activity" EXACT [] xref: Reactome:198811 "dehydroascorbic acid transporter activity" is_a: GO:0051183 ! vitamin transporter activity [Term] id: GO:0033301 name: cell cycle comprising mitosis without cytokinesis namespace: biological_process def: "A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N)." [GOC:expert_vm, GOC:mah] comment: Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers. is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0033302 name: quercetin O-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [CHEBI:28299, CHEBI:28529, GOC:mah, MetaCyc:PWY-5321] synonym: "quercetin O-glucoside metabolism" EXACT [] is_a: GO:0016140 ! O-glycoside metabolic process [Term] id: GO:0033303 name: quercetin O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin." [CHEBI:28299, CHEBI:28529, GOC:mah, MetaCyc:PWY-5321] synonym: "quercetin O-glucoside anabolism" EXACT [] synonym: "quercetin O-glucoside biosynthesis" EXACT [] synonym: "quercetin O-glucoside formation" EXACT [] synonym: "quercetin O-glucoside synthesit" EXACT [] xref: MetaCyc:PWY-5321 is_a: GO:0016141 ! O-glycoside biosynthetic process is_a: GO:0033302 ! quercetin O-glucoside metabolic process [Term] id: GO:0033304 name: chlorophyll a metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorophyll a." [CHEBI:18230, GOC:mah] subset: gosubset_prok synonym: "chlorophyll a metabolism" EXACT [] is_a: GO:0015994 ! chlorophyll metabolic process [Term] id: GO:0033305 name: chlorophyll a biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of chlorophyll a." [CHEBI:18230, GOC:mah] subset: gosubset_prok synonym: "chlorophyll a anabolism" EXACT [] synonym: "chlorophyll a biosynthesis" EXACT [] synonym: "chlorophyll a formation" EXACT [] synonym: "chlorophyll a synthesis" EXACT [] is_a: GO:0015995 ! chlorophyll biosynthetic process is_a: GO:0033304 ! chlorophyll a metabolic process [Term] id: GO:0033306 name: phytol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [CHEBI:17327, GOC:mah] synonym: "phytol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0033307 name: phytol salvage namespace: biological_process def: "A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis." [GOC:mah, MetaCyc:PWY-5107] synonym: "phytol salvage pathway" EXACT [] xref: MetaCyc:PWY-5107 is_a: GO:0033520 ! phytol biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0033308 name: hydroxyectoine transport namespace: biological_process def: "The directed movement of hydroxyectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] subset: gosubset_prok is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0033309 name: SBF transcription complex namespace: cellular_component def: "A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi6p and the activator Swi4p, and is associated with additional proteins known as Whi5p and Msa1p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:7917338] synonym: "SBF complex" EXACT [GOC:mah] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0033310 name: chlorophyll a catabolic process namespace: biological_process def: "The chemical reactions and pathways leading to the breakdown of chlorophyll a." [CHEBI:18230, GOC:mah] subset: gosubset_prok synonym: "chlorophyll a breakdown" EXACT [] synonym: "chlorophyll a catabolism" EXACT [] synonym: "chlorophyll a degradation" EXACT [] xref: MetaCyc:PWY-5086 xref: MetaCyc:PWY-5098 is_a: GO:0015996 ! chlorophyll catabolic process is_a: GO:0033304 ! chlorophyll a metabolic process [Term] id: GO:0033311 name: chlorophyll a biosynthetic process via phytyl diphosphate namespace: biological_process def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate phytyl diphosphate." [CHEBI:18230, GOC:mah, MetaCyc:PWY-5086] subset: gosubset_prok synonym: "chlorophyll a anabolism via phytyl diphosphate" EXACT [] synonym: "chlorophyll a biosynthesis via phytyl diphosphate" EXACT [] synonym: "chlorophyll a biosynthetic process via phytyl-PP" EXACT [] synonym: "chlorophyll a formation via phytyl chlorophyll a formation via phytyl-PP" EXACT [] synonym: "chlorophyll a synthesis via phytyl diphosphate" EXACT [] xref: MetaCyc:PWY-5086 is_a: GO:0033305 ! chlorophyll a biosynthetic process [Term] id: GO:0033312 name: chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a namespace: biological_process def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate geranylgeranyl-chlorophyll a." [CHEBI:18230, GOC:mah, MetaCyc:PWY-5064] subset: gosubset_prok synonym: "chlorophyll a anabolism via geranylgeranyl-chlorophyll a" EXACT [] synonym: "chlorophyll a biosynthesis via geranylgeranyl-chlorophyll a" EXACT [] synonym: "chlorophyll a formation via geranylgeranyl-chlorophyll a" EXACT [] synonym: "chlorophyll a synthesis via geranylgeranyl-chlorophyll a" EXACT [] xref: MetaCyc:PWY-5064 is_a: GO:0033305 ! chlorophyll a biosynthetic process [Term] id: GO:0033313 name: meiotic cell cycle checkpoint namespace: biological_process def: "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mah] is_a: GO:0000075 ! cell cycle checkpoint is_a: GO:0051445 ! regulation of meiotic cell cycle [Term] id: GO:0033314 name: mitotic cell cycle DNA replication checkpoint namespace: biological_process alt_id: GO:0031574 def: "A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mah] synonym: "S-M checkpoint" EXACT [] synonym: "S-M DNA replication checkpoint" EXACT [GOC:vw] is_a: GO:0000076 ! DNA replication checkpoint is_a: GO:0007093 ! mitotic cell cycle checkpoint [Term] id: GO:0033315 name: meiotic cell cycle DNA replication checkpoint namespace: biological_process def: "A cell cycle checkpoint that acts during a meiotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the haploid genome." [GOC:mah] is_a: GO:0000076 ! DNA replication checkpoint is_a: GO:0033313 ! meiotic cell cycle checkpoint [Term] id: GO:0033316 name: meiotic spindle assembly checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah] is_a: GO:0033313 ! meiotic cell cycle checkpoint is_a: GO:0071173 ! spindle assembly checkpoint [Term] id: GO:0033317 name: pantothenate biosynthetic process from valine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid, from other compounds, including valine." [GOC:mah, MetaCyc:PANTO-PWY, MetaCyc:PWY-3921] synonym: "pantothenate anabolism from valine" EXACT [] synonym: "pantothenate biosynthesis from valine" EXACT [] synonym: "pantothenate formation from valine" EXACT [] synonym: "pantothenate synthesis from valine" EXACT [] xref: MetaCyc:PANTO-PWY is_a: GO:0015940 ! pantothenate biosynthetic process [Term] id: GO:0033318 name: pantothenate biosynthetic process from 2-oxypantoyl lactone namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid, from other compounds, including 2-oxypantoyl lactone." [GOC:mah, MetaCyc:PWY-3961] synonym: "pantothenate anabolism from 2-oxypantoyl lactone" EXACT [] synonym: "pantothenate biosynthesis from 2-oxypantoyl lactone" EXACT [] synonym: "pantothenate formation from 2-oxypantoyl lactone" EXACT [] synonym: "pantothenate synthesis from 2-oxypantoyl lactone" EXACT [] xref: MetaCyc:PWY-3961 is_a: GO:0015940 ! pantothenate biosynthetic process [Term] id: GO:0033319 name: UDP-D-xylose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-D-xylose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0042732 ! D-xylose metabolic process [Term] id: GO:0033320 name: UDP-D-xylose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-4821] synonym: "UDP-D-xylose anabolism" EXACT [] synonym: "UDP-D-xylose biosynthesis" EXACT [] synonym: "UDP-D-xylose formation" EXACT [] synonym: "UDP-D-xylose synthesis" EXACT [] xref: MetaCyc:PWY-4821 is_a: GO:0033319 ! UDP-D-xylose metabolic process is_a: GO:0042842 ! D-xylose biosynthetic process [Term] id: GO:0033321 name: homomethionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] synonym: "homomethionine metabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0033322 name: homomethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] synonym: "homomethionine anabolism" EXACT [] synonym: "homomethionine biosynthesis" EXACT [] synonym: "homomethionine formation" EXACT [] synonym: "homomethionine synthesis" EXACT [] xref: MetaCyc:PWY-1186 is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0033321 ! homomethionine metabolic process [Term] id: GO:0033323 name: choline biosynthetic process via CDP-choline namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate CDP-choline." [GOC:mah, MetaCyc:PWY-3561] subset: gosubset_prok synonym: "choline anabolism via CDP-choline" EXACT [] synonym: "choline biosynthesis via CDP-choline" EXACT [] synonym: "choline formation via CDP-choline" EXACT [] synonym: "choline synthesis via CDP-choline" EXACT [] xref: MetaCyc:PWY-3561 xref: MetaCyc:PWY-4762 is_a: GO:0042425 ! choline biosynthetic process [Term] id: GO:0033324 name: choline biosynthetic process via N-monomethylethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine." [GOC:mah, MetaCyc:PWY-3542] subset: gosubset_prok synonym: "choline anabolism via N-monomethylethanolamine" EXACT [] synonym: "choline biosynthesis via N-monomethylethanolamine" EXACT [] synonym: "choline formation via N-monomethylethanolamine" EXACT [] synonym: "choline synthesis via N-monomethylethanolamine" EXACT [] xref: MetaCyc:PWY-3542 xref: MetaCyc:PWY-4762 is_a: GO:0042425 ! choline biosynthetic process [Term] id: GO:0033325 name: choline biosynthetic process via phosphoryl-ethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate phosphoryl-ethanolamine." [GOC:mah, MetaCyc:PWY-3385] subset: gosubset_prok synonym: "choline anabolism via phosphoryl-ethanolamine" EXACT [] synonym: "choline biosynthesis via phosphoryl-ethanolamine" EXACT [] synonym: "choline formation via phosphoryl-ethanolamine" EXACT [] synonym: "choline synthesis via phosphoryl-ethanolamine" EXACT [] xref: MetaCyc:PWY-3385 xref: MetaCyc:PWY-4762 is_a: GO:0042425 ! choline biosynthetic process [Term] id: GO:0033326 name: cerebrospinal fluid secretion namespace: biological_process def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, http://users.ahsc.arizona.edu/davis/csf.htm, PMID:10716451] synonym: "CSF secretion" EXACT [] is_a: GO:0007589 ! body fluid secretion [Term] id: GO:0033327 name: Leydig cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:ln, PMID:12050120] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0008584 ! male gonad development [Term] id: GO:0033328 name: peroxisome membrane targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane." [GOC:rb, PMID:15133130] synonym: "mPTS binding" EXACT [] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0033329 name: kaempferol O-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [CHEBI:30200, GOC:mah, MetaCyc:PWY-5320] synonym: "kaempferol O-glucoside metabolism" EXACT [] is_a: GO:0016140 ! O-glycoside metabolic process [Term] id: GO:0033330 name: kaempferol O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol." [CHEBI:30200, GOC:mah, MetaCyc:PWY-5320] synonym: "kaempferol O-glucoside anabolism" EXACT [] synonym: "kaempferol O-glucoside biosynthesis" EXACT [] synonym: "kaempferol O-glucoside formation" EXACT [] synonym: "kaempferol O-glucoside synthesit" EXACT [] xref: MetaCyc:PWY-5320 is_a: GO:0016141 ! O-glycoside biosynthetic process is_a: GO:0033329 ! kaempferol O-glucoside metabolic process [Term] id: GO:0033331 name: ent-kaurene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] subset: gosubset_prok synonym: "ent-kaurene metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process [Term] id: GO:0033332 name: ent-kaurene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ent-kaurene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] subset: gosubset_prok synonym: "ent-kaurene anabolism" EXACT [] synonym: "ent-kaurene biosynthesis" EXACT [] synonym: "ent-kaurene formation" EXACT [] synonym: "ent-kaurene synthesis" EXACT [] xref: MetaCyc:PWY-5032 xref: MetaCyc:PWY-5035 is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0033331 ! ent-kaurene metabolic process [Term] id: GO:0033333 name: fin development namespace: biological_process def: "The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0048736 ! appendage development [Term] id: GO:0033334 name: fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a fin are generated and organized." [GOC:dgh] is_a: GO:0035107 ! appendage morphogenesis relationship: part_of GO:0033333 ! fin development [Term] id: GO:0033335 name: anal fin development namespace: biological_process def: "The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033338 ! medial fin development [Term] id: GO:0033336 name: caudal fin development namespace: biological_process def: "The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033338 ! medial fin development [Term] id: GO:0033337 name: dorsal fin development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033338 ! medial fin development [Term] id: GO:0033338 name: medial fin development namespace: biological_process def: "The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033333 ! fin development [Term] id: GO:0033339 name: pectoral fin development namespace: biological_process def: "The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033333 ! fin development [Term] id: GO:0033340 name: pelvic fin development namespace: biological_process def: "The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033333 ! fin development [Term] id: GO:0033341 name: regulation of collagen binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collagen binding." [GOC:mah] is_a: GO:0043393 ! regulation of protein binding [Term] id: GO:0033342 name: negative regulation of collagen binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding." [GOC:mah] synonym: "down regulation of collagen binding" EXACT [] synonym: "down-regulation of collagen binding" EXACT [] synonym: "downregulation of collagen binding" EXACT [] synonym: "inhibition of collagen binding" NARROW [] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:0033341 ! regulation of collagen binding [Term] id: GO:0033343 name: positive regulation of collagen binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen binding." [GOC:mah] synonym: "activation of collagen binding" NARROW [] synonym: "stimulation of collagen binding" NARROW [] synonym: "up regulation of collagen binding" EXACT [] synonym: "up-regulation of collagen binding" EXACT [] synonym: "upregulation of collagen binding" EXACT [] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:0033341 ! regulation of collagen binding [Term] id: GO:0033344 name: cholesterol efflux namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:sart] synonym: "cholesterol export" EXACT [] is_a: GO:0030301 ! cholesterol transport [Term] id: GO:0033345 name: asparagine catabolic process via L-aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah] xref: MetaCyc:ASPARAGINE-DEG1-PWY is_a: GO:0006530 ! asparagine catabolic process [Term] id: GO:0033346 name: asparagine catabolic process via 2-oxosuccinamate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate." [GOC:mah, MetaCyc:PWY-4002] xref: MetaCyc:PWY-4002 is_a: GO:0006530 ! asparagine catabolic process [Term] id: GO:0033347 name: tetrose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah] subset: gosubset_prok synonym: "tetrose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0033348 name: tetrose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah] synonym: "tetrose anabolism" EXACT [] synonym: "tetrose biosynthesis" EXACT [] synonym: "tetrose formation" EXACT [] synonym: "tetrose synthesis" EXACT [] is_a: GO:0033347 ! tetrose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process [Term] id: GO:0033349 name: apiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [CHEBI:16689, GOC:mah] synonym: "apiose metabolism" EXACT [] is_a: GO:0033347 ! tetrose metabolic process [Term] id: GO:0033350 name: apiose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [CHEBI:16689, GOC:mah] synonym: "apiose anabolism" EXACT [] synonym: "apiose biosynthesis" EXACT [] synonym: "apiose formation" EXACT [] synonym: "apiose synthesis" EXACT [] is_a: GO:0033348 ! tetrose biosynthetic process is_a: GO:0033349 ! apiose metabolic process [Term] id: GO:0033351 name: UDP-D-apiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-D-apiose, uridinediphosphoapiose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-D-apiose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0033349 ! apiose metabolic process [Term] id: GO:0033352 name: UDP-D-apiose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-5113] synonym: "UDP-D-apiose anabolism" EXACT [] synonym: "UDP-D-apiose biosynthesis" EXACT [] synonym: "UDP-D-apiose formation" EXACT [] synonym: "UDP-D-apiose synthesis" EXACT [] xref: MetaCyc:PWY-4821 xref: MetaCyc:PWY-5113 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033350 ! apiose biosynthetic process is_a: GO:0033351 ! UDP-D-apiose metabolic process [Term] id: GO:0033353 name: S-adenosylmethionine cycle namespace: biological_process def: "A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041] synonym: "SAM cycle" EXACT [] xref: MetaCyc:PWY-5041 is_a: GO:0046500 ! S-adenosylmethionine metabolic process [Term] id: GO:0033354 name: chlorophyll cycle namespace: biological_process def: "A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates." [GOC:mah, MetaCyc:PWY-5068] xref: MetaCyc:PWY-5068 is_a: GO:0015994 ! chlorophyll metabolic process [Term] id: GO:0033355 name: ascorbate glutathione cycle namespace: biological_process def: "A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH." [GOC:mah, MetaCyc:PWY-2261] synonym: "hydrogen peroxide detoxification" RELATED [] xref: MetaCyc:PWY-2261 is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042744 ! hydrogen peroxide catabolic process [Term] id: GO:0033356 name: UDP-L-arabinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-L-arabinose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0046373 ! L-arabinose metabolic process [Term] id: GO:0033357 name: L-arabinose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose." [CHEBI:22599, GOC:mah] synonym: "L-arabinose anabolism" EXACT [] synonym: "L-arabinose biosynthesis" EXACT [] synonym: "L-arabinose formation" EXACT [] synonym: "L-arabinose synthesis" EXACT [] is_a: GO:0019567 ! arabinose biosynthetic process [Term] id: GO:0033358 name: UDP-L-arabinose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-82] synonym: "UDP-L-arabinose anabolism" EXACT [] synonym: "UDP-L-arabinose biosynthesis" EXACT [] synonym: "UDP-L-arabinose formation" EXACT [] synonym: "UDP-L-arabinose synthesis" EXACT [] xref: MetaCyc:PWY-63 xref: MetaCyc:PWY-82 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033357 ! L-arabinose biosynthetic process [Term] id: GO:0033359 name: lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-] subset: gosubset_prok synonym: "lysine anabolism via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT [] synonym: "lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT [] synonym: "lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] synonym: "lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] xref: MetaCyc:DAPLYSINESYN-PWY is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate [Term] id: GO:0033360 name: lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:PWY-2941] subset: gosubset_prok synonym: "lysine anabolism via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT [] synonym: "lysine biosynthetic process via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT [] synonym: "lysine formation via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] synonym: "lysine synthesis via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] xref: MetaCyc:PWY-2941 is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate [Term] id: GO:0033361 name: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step." [GOC:mah, MetaCyc:PWY-2942] subset: gosubset_prok synonym: "lysine anabolism via diaminopimelate, dehydrogenase pathway" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway" EXACT [] synonym: "lysine formation via diaminopimelate, dehydrogenase pathway" EXACT [] synonym: "lysine synthesis via diaminopimelate, dehydrogenase pathway" EXACT [] xref: MetaCyc:PWY-2942 is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate [Term] id: GO:0033362 name: lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps." [GOC:mah, MetaCyc:PWY-5097] subset: gosubset_prok synonym: "lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] synonym: "lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] synonym: "lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] synonym: "lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] xref: MetaCyc:PWY-5097 is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate [Term] id: GO:0033363 name: secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization [Term] id: GO:0033364 name: mast cell secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "mast cell secretory granule maturation" RELATED [] synonym: "mast cell secretory granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0033365 name: protein localization to organelle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] synonym: "protein localisation to organelle" EXACT [GOC:mah] synonym: "protein localization in organelle" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0033366 name: protein localization in secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah] synonym: "protein localisation in secretory granule" EXACT [GOC:mah] synonym: "protein localization to secretory granule" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0033367 name: protein localization in mast cell secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah] synonym: "protein localisation in mast cell secretory granule" EXACT [GOC:mah] is_a: GO:0033366 ! protein localization in secretory granule relationship: part_of GO:0033364 ! mast cell secretory granule organization [Term] id: GO:0033368 name: protease localization in mast cell secretory granule namespace: biological_process def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah] synonym: "protease localisation in mast cell secretory granule" EXACT [GOC:mah] is_a: GO:0033367 ! protein localization in mast cell secretory granule [Term] id: GO:0033369 name: establishment of protein localization in mast cell secretory granule namespace: biological_process def: "The directed movement of a protein to a location within a secretory granule in a mast cell." [GOC:mah] synonym: "establishment of protein localisation in mast cell secretory granule" EXACT [GOC:mah] is_a: GO:0006886 ! intracellular protein transport relationship: part_of GO:0033367 ! protein localization in mast cell secretory granule [Term] id: GO:0033370 name: maintenance of protein location in mast cell secretory granule namespace: biological_process def: "A process in which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of protein localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "mast cell protein retention" EXACT [] is_a: GO:0045185 ! maintenance of protein location relationship: part_of GO:0033367 ! protein localization in mast cell secretory granule [Term] id: GO:0033371 name: T cell secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah] synonym: "T lymphocyte secretory granule organization" EXACT [] synonym: "T-cell secretory granule organization" EXACT [] synonym: "T-lymphocyte secretory granule maturation" RELATED [] synonym: "T-lymphocyte secretory granule organization" EXACT [] is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0033372 name: establishment of protease localization in mast cell secretory granule namespace: biological_process def: "The directed movement of a protease to a location within a secretory granule in a mast cell." [GOC:mah] synonym: "establishment of protease localisation in mast cell secretory granule" EXACT [GOC:mah] is_a: GO:0033369 ! establishment of protein localization in mast cell secretory granule relationship: part_of GO:0033368 ! protease localization in mast cell secretory granule [Term] id: GO:0033373 name: maintenance of protease location in mast cell secretory granule namespace: biological_process def: "A process in which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of protease localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "mast cell protease retention" EXACT [] is_a: GO:0033370 ! maintenance of protein location in mast cell secretory granule relationship: part_of GO:0033368 ! protease localization in mast cell secretory granule [Term] id: GO:0033374 name: protein localization in T cell secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] synonym: "protein localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "protein localization in T lymphocyte secretory granule" EXACT [] synonym: "protein localization in T-cell secretory granule" EXACT [] synonym: "protein localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033366 ! protein localization in secretory granule relationship: part_of GO:0033371 ! T cell secretory granule organization [Term] id: GO:0033375 name: protease localization in T cell secretory granule namespace: biological_process def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] synonym: "protease localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "protease localization in T lymphocyte secretory granule" EXACT [] synonym: "protease localization in T-cell secretory granule" EXACT [] synonym: "protease localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033374 ! protein localization in T cell secretory granule [Term] id: GO:0033376 name: establishment of protein localization in T cell secretory granule namespace: biological_process def: "The directed movement of a protein to a location within a secretory granule in a T cell." [GOC:mah] synonym: "establishment of protein localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "establishment of protein localization in T lymphocyte secretory granule" EXACT [] synonym: "establishment of protein localization in T-cell secretory granule" EXACT [] synonym: "establishment of protein localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0006886 ! intracellular protein transport relationship: part_of GO:0033374 ! protein localization in T cell secretory granule [Term] id: GO:0033377 name: maintenance of protein location in T cell secretory granule namespace: biological_process def: "A process in which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of protein localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of protein localization in T lymphocyte secretory granule" EXACT [] synonym: "maintenance of protein localization in T-cell secretory granule" EXACT [] synonym: "maintenance of protein localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0045185 ! maintenance of protein location relationship: part_of GO:0033374 ! protein localization in T cell secretory granule [Term] id: GO:0033378 name: establishment of protease localization in T cell secretory granule namespace: biological_process def: "The directed movement of a protease to a location within a secretory granule in a T cell." [GOC:mah] synonym: "establishment of protease localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "establishment of protease localization in T lymphocyte secretory granule" EXACT [] synonym: "establishment of protease localization in T-cell secretory granule" EXACT [] synonym: "establishment of protease localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033376 ! establishment of protein localization in T cell secretory granule relationship: part_of GO:0033375 ! protease localization in T cell secretory granule [Term] id: GO:0033379 name: maintenance of protease location in T cell secretory granule namespace: biological_process def: "A process in which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of protease localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of protease localization in T lymphocyte secretory granule" EXACT [] synonym: "maintenance of protease localization in T-cell secretory granule" EXACT [] synonym: "maintenance of protease localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033377 ! maintenance of protein location in T cell secretory granule relationship: part_of GO:0033375 ! protease localization in T cell secretory granule [Term] id: GO:0033380 name: granzyme B localization in T cell secretory granule namespace: biological_process def: "Any process in which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] synonym: "granzyme B localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "granzyme B localization in T lymphocyte secretory granule" EXACT [] synonym: "granzyme B localization in T-cell secretory granule" EXACT [] synonym: "granzyme B localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033375 ! protease localization in T cell secretory granule [Term] id: GO:0033381 name: establishment of granzyme B localization in T cell secretory granule namespace: biological_process def: "The directed movement of the protease granzyme B to a location within a secretory granule in a T cell." [GOC:mah] synonym: "establishment of granzyme B localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "establishment of granzyme B localization in T lymphocyte secretory granule" EXACT [] synonym: "establishment of granzyme B localization in T-cell secretory granule" EXACT [] synonym: "establishment of granzyme B localization in T-lymphocyte secretory granule" EXACT [] synonym: "T-lymphocyte secretory granule storage of granzyme B" RELATED [] is_a: GO:0033378 ! establishment of protease localization in T cell secretory granule relationship: part_of GO:0033380 ! granzyme B localization in T cell secretory granule [Term] id: GO:0033382 name: maintenance of granzyme B location in T cell secretory granule namespace: biological_process def: "A process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:mah] synonym: "maintenance of granzyme B localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of granzyme B localization in T lymphocyte secretory granule" EXACT [] synonym: "maintenance of granzyme B localization in T-cell secretory granule" EXACT [] synonym: "maintenance of granzyme B localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033379 ! maintenance of protease location in T cell secretory granule relationship: part_of GO:0033380 ! granzyme B localization in T cell secretory granule [Term] id: GO:0033383 name: geranyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah, MetaCyc:PWY-5122] synonym: "geranyl diphosphate metabolism" EXACT [] synonym: "geranyldiphosphate metabolic process" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0016090 ! prenol metabolic process [Term] id: GO:0033384 name: geranyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of geranyl diphosphate." [GOC:mah, MetaCyc:PWY-5122] synonym: "geranyl diphosphate anabolism" EXACT [] synonym: "geranyl diphosphate biosynthesis" EXACT [] synonym: "geranyl diphosphate formation" EXACT [] synonym: "geranyl diphosphate synthesis" EXACT [] synonym: "geranyldiphosphate biosynthetic process" EXACT [] xref: MetaCyc:PWY-5122 is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016091 ! prenol biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0033383 ! geranyl diphosphate metabolic process [Term] id: GO:0033385 name: geranylgeranyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah, MetaCyc:PWY-5120] synonym: "geranylgeranyl diphosphate metabolism" EXACT [] synonym: "geranylgeranyldiphosphate metabolic process" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0016090 ! prenol metabolic process [Term] id: GO:0033386 name: geranylgeranyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate." [GOC:mah, MetaCyc:PWY-5120] synonym: "geranylgeranyl diphosphate anabolism" EXACT [] synonym: "geranylgeranyl diphosphate biosynthesis" EXACT [] synonym: "geranylgeranyl diphosphate formation" EXACT [] synonym: "geranylgeranyl diphosphate synthesis" EXACT [] xref: MetaCyc:PWY-5120 xref: MetaCyc:PWY-5121 is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016091 ! prenol biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process [Term] id: GO:0033387 name: putrescine biosynthetic process from ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46] synonym: "putrescine anabolism from ornithine" EXACT [] synonym: "putrescine biosynthesis from ornithine" EXACT [] synonym: "putrescine formation from ornithine" EXACT [] synonym: "putrescine synthesis from ornithine" EXACT [] is_a: GO:0009446 ! putrescine biosynthetic process [Term] id: GO:0033388 name: putrescine biosynthetic process from arginine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine." [GOC:mah, MetaCyc:PWY-46] subset: gosubset_prok synonym: "putrescine anabolism from arginine" EXACT [] synonym: "putrescine biosynthesis from arginine" EXACT [] synonym: "putrescine formation from arginine" EXACT [] synonym: "putrescine synthesis from arginine" EXACT [] is_a: GO:0009446 ! putrescine biosynthetic process [Term] id: GO:0033389 name: putrescine biosynthetic process from arginine, using agmatinase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step." [GOC:mah, MetaCyc:PWY-40] subset: gosubset_prok synonym: "putrescine anabolism from arginine, using agmatinase" EXACT [] synonym: "putrescine biosynthesis from arginine, using agmatinase" EXACT [] synonym: "putrescine formation from arginine, using agmatinase" EXACT [] synonym: "putrescine synthesis from arginine, using agmatinase" EXACT [] is_a: GO:0033388 ! putrescine biosynthetic process from arginine [Term] id: GO:0033390 name: putrescine biosynthetic process from arginine via N-carbamoylputrescine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps." [GOC:mah, MetaCyc:PWY-43] subset: gosubset_prok synonym: "putrescine anabolism from arginine via N-carbamoylputrescine" EXACT [] synonym: "putrescine biosynthesis from arginine via N-carbamoylputrescine" EXACT [] synonym: "putrescine formation from arginine via N-carbamoylputrescine" EXACT [] synonym: "putrescine synthesis from arginine via N-carbamoylputrescine" EXACT [] is_a: GO:0033388 ! putrescine biosynthetic process from arginine [Term] id: GO:0033391 name: chromatoid body namespace: cellular_component def: "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182)." [PMID:17183363] is_a: GO:0035770 ! RNA granule [Term] id: GO:0033392 name: actin homodimerization activity namespace: molecular_function def: "Interacting selectively and non-covalently with an identical actin monomer to form a homodimer." [GOC:mah] subset: gosubset_prok synonym: "actin dimerization activity" BROAD [] synonym: "actin polymerizing activity" RELATED [] is_a: GO:0042803 ! protein homodimerization activity [Term] id: GO:0033393 name: homogalacturonan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of homogalacturonan, a pectidic polymer, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:mah] subset: gosubset_prok synonym: "homogalacturonan breakdown" EXACT [] synonym: "homogalacturonan catabolism" EXACT [] synonym: "homogalacturonan degradation" EXACT [] xref: MetaCyc:PWY-1081 is_a: GO:0045490 ! pectin catabolic process [Term] id: GO:0033394 name: beta-alanine biosynthetic process via 1,3 diaminopropane namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane." [GOC:mah, MetaCyc:PWY-3981] synonym: "beta-alanine anabolism via 1,3 diaminopropane" EXACT [] synonym: "beta-alanine biosynthesis via 1,3 diaminopropane" EXACT [] synonym: "beta-alanine formation via 1,3 diaminopropane" EXACT [] synonym: "beta-alanine synthesis via 1,3 diaminopropane" EXACT [] xref: MetaCyc:PWY-3981 is_a: GO:0019483 ! beta-alanine biosynthetic process [Term] id: GO:0033395 name: beta-alanine biosynthetic process via 3-hydroxypropionate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate." [GOC:mah, MetaCyc:PWY-3941] synonym: "beta-alanine anabolism via 3-hydroxypropionate" EXACT [] synonym: "beta-alanine biosynthesis via 3-hydroxypropionate" EXACT [] synonym: "beta-alanine formation via 3-hydroxypropionate" EXACT [] synonym: "beta-alanine synthesis via 3-hydroxypropionate" EXACT [] xref: MetaCyc:PWY-3941 is_a: GO:0019483 ! beta-alanine biosynthetic process [Term] id: GO:0033396 name: beta-alanine biosynthetic process via 3-ureidopropionate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate." [GOC:mah, MetaCyc:PWY-3982] synonym: "beta-alanine anabolism via 3-ureidopropionate" EXACT [] synonym: "beta-alanine formation via 3-ureidopropionate" EXACT [] synonym: "beta-alanine synthesis via 3-ureidopropionate" EXACT [] xref: MetaCyc:PWY-3982 is_a: GO:0019483 ! beta-alanine biosynthetic process [Term] id: GO:0033397 name: zeatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:15333, GOC:mah] synonym: "zeatin metabolism" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process [Term] id: GO:0033398 name: zeatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:15333, GOC:mah] subset: gosubset_prok synonym: "zeatin anabolism" EXACT [] synonym: "zeatin biosynthesis" EXACT [] synonym: "zeatin formation" EXACT [] synonym: "zeatin synthesis" EXACT [] is_a: GO:0009691 ! cytokinin biosynthetic process is_a: GO:0033397 ! zeatin metabolic process [Term] id: GO:0033399 name: cis-zeatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:12800, GOC:mah] synonym: "cis-zeatin metabolism" EXACT [] is_a: GO:0033397 ! zeatin metabolic process [Term] id: GO:0033400 name: trans-zeatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:16522, GOC:mah] synonym: "trans-zeatin metabolism" EXACT [] is_a: GO:0033397 ! zeatin metabolic process [Term] id: GO:0033401 name: UUU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UUU codon." [GOC:mah] comment: Note that in the standard genetic code, TTT codes for phenylalanine. synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TTT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033402 name: UUC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UUC codon." [GOC:mah] comment: Note that in the standard genetic code, TTC codes for phenylalanine. synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TTC codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033403 name: UUA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UUA codon." [GOC:mah] comment: Note that in the standard genetic code, TTA codes for leucine. synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TTA codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033404 name: UUG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UUG codon." [GOC:mah] comment: Note that in the standard genetic code, TTG codes for leucine. synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TTG codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033405 name: UCU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UCU codon." [GOC:mah] comment: Note that in the standard genetic code, TCT codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TCT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033406 name: UCC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UCC codon." [GOC:mah] comment: Note that in the standard genetic code, TCC codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TCC codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033407 name: UCA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UCA codon." [GOC:mah] comment: Note that in the standard genetic code, TCA codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TCA codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033408 name: UCG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UCG codon." [GOC:mah] comment: Note that in the standard genetic code, TCG codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TCG codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033409 name: UAU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UAU codon." [GOC:mah] comment: Note that in the standard genetic code, TAT codes for tyrosine. synonym: "TAT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033410 name: UAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UAC codon." [GOC:mah] comment: Note that in the standard genetic code, TAC codes for tyrosine. synonym: "TAC codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033411 name: UAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UAA codon." [GOC:mah] comment: Note that in the standard genetic code, TAA is a stop codon (ochre) and is not normally read by a tRNA. synonym: "TAA codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033412 name: UAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UAG codon." [GOC:mah] comment: Note that in the standard genetic code, TAG is a stop codon (amber) and is not normally read by a tRNA. synonym: "TAG codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033413 name: UGU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UGU codon." [GOC:mah] comment: Note that in the standard genetic code, TGT codes for cysteine. synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TGT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033414 name: UGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UGC codon." [GOC:mah] comment: Note that in the standard genetic code, TGC codes for cysteine. synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TGC codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033415 name: UGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UGA codon." [GOC:mah] comment: Note that in the standard genetic code, TGA is a stop codon (opal) and is not normally read by a tRNA. synonym: "TGA codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033416 name: UGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UGG codon." [GOC:mah] comment: Note that in the standard genetic code, TGG codes for tryptophan. synonym: "TGG codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "tryptophan tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033417 name: CUU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CUU codon." [GOC:mah] comment: Note that in the standard genetic code, CTT codes for leucine. synonym: "CTT codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033418 name: CUC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CUC codon." [GOC:mah] comment: Note that in the standard genetic code, CTC codes for leucine. synonym: "CTC codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033419 name: CUA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CUA codon." [GOC:mah] comment: Note that in the standard genetic code, CTA codes for leucine. synonym: "CTA codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033420 name: CUG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CUG codon." [GOC:mah] comment: Note that in the standard genetic code, CTG codes for leucine. synonym: "CTG codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033421 name: CCU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCU codon." [GOC:mah] comment: Note that in the standard genetic code, CCT codes for proline. synonym: "CCT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033422 name: CCC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCC codon." [GOC:mah] comment: Note that in the standard genetic code, CCC codes for proline. synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033423 name: CCA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCA codon." [GOC:mah] comment: Note that in the standard genetic code, CCA codes for proline. synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033424 name: CCG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCG codon." [GOC:mah] comment: Note that in the standard genetic code, CCG codes for proline. synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033425 name: CAU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAU codon." [GOC:mah] comment: Note that in the standard genetic code, CAT codes for histidine. synonym: "CAT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033426 name: CAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAC codon." [GOC:mah] comment: Note that in the standard genetic code, CAC codes for histidine. synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033427 name: CAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAA codon." [GOC:mah] comment: Note that in the standard genetic code, CAA codes for glutamine. synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033428 name: CAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAG codon." [GOC:mah] comment: Note that in the standard genetic code, CAG codes for glutamine. synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033429 name: CGU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGU codon." [GOC:mah] comment: Note that in the standard genetic code, CGT codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "CGT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033430 name: CGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGC codon." [GOC:mah] comment: Note that in the standard genetic code, CGC codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033431 name: CGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGA codon." [GOC:mah] comment: Note that in the standard genetic code, CGA codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033432 name: CGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGG codon." [GOC:mah] comment: Note that in the standard genetic code, CGG codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033433 name: AUU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AUU codon." [GOC:mah] comment: Note that in the standard genetic code, ATT codes for isoleucine. synonym: "ATT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033434 name: AUC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AUC codon." [GOC:mah] comment: Note that in the standard genetic code, ATC codes for isoleucine. synonym: "ATC codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033435 name: AUA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AUA codon." [GOC:mah] comment: Note that in the standard genetic code, ATA codes for isoleucine. synonym: "ATA codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033436 name: AUG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AUG codon." [GOC:mah] comment: Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon. synonym: "ATG codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "initiator methionine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "methionine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033437 name: ACU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACU codon." [GOC:mah] comment: Note that in the standard genetic code, ACT codes for threonine. synonym: "ACT codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033438 name: ACC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACC codon." [GOC:mah] comment: Note that in the standard genetic code, ACC codes for threonine. synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033439 name: ACA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACA codon." [GOC:mah] comment: Note that in the standard genetic code, ACA codes for threonine. synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033440 name: ACG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACG codon." [GOC:mah] comment: Note that in the standard genetic code, ACG codes for threonine. synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033441 name: AAU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAU codon." [GOC:mah] comment: Note that in the standard genetic code, AAT codes for asparagine. synonym: "AAT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033442 name: AAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAC codon." [GOC:mah] comment: Note that in the standard genetic code, AAC codes for asparagine. synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033443 name: AAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAA codon." [GOC:mah] comment: Note that in the standard genetic code, AAA codes for lysine. synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033444 name: AAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAG codon." [GOC:mah] comment: Note that in the standard genetic code, AAG codes for lysine. synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033445 name: AGU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGU codon." [GOC:mah] comment: Note that in the standard genetic code, AGT codes for serine. synonym: "AGT codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033446 name: AGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGC codon." [GOC:mah] comment: Note that in the standard genetic code, AGC codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033447 name: AGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGA codon." [GOC:mah] comment: Note that in the standard genetic code, AGA codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033448 name: AGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGG codon." [GOC:mah] comment: Note that in the standard genetic code, AGG codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033449 name: GUU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GUU codon." [GOC:mah] comment: Note that in the standard genetic code, GTT codes for valine. synonym: "GTT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033450 name: GUC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GUC codon." [GOC:mah] comment: Note that in the standard genetic code, GTC codes for valine. synonym: "GTC codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033451 name: GUA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GUA codon." [GOC:mah] comment: Note that in the standard genetic code, GTA codes for valine. synonym: "GTA codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033452 name: GUG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GUG codon." [GOC:mah] comment: Note that in the standard genetic code, GTG codes for valine. synonym: "GTG codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033453 name: GCU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCU codon." [GOC:mah] comment: Note that in the standard genetic code, GCT codes for alanine. synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "GCT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033454 name: GCC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCC codon." [GOC:mah] comment: Note that in the standard genetic code, GCC codes for alanine. synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033455 name: GCA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCA codon." [GOC:mah] comment: Note that in the standard genetic code, GCA codes for alanine. synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033456 name: GCG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCG codon." [GOC:mah] comment: Note that in the standard genetic code, GCG codes for alanine. synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033457 name: GAU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAU codon." [GOC:mah] comment: Note that in the standard genetic code, GAT codes for aspartic acid. synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "GAT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033458 name: GAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAC codon." [GOC:mah] comment: Note that in the standard genetic code, GAC codes for aspartic acid. synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033459 name: GAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAA codon." [GOC:mah] comment: Note that in the standard genetic code, GAA codes for glutamic acid. synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033460 name: GAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAG codon." [GOC:mah] comment: Note that in the standard genetic code, GAG codes for glutamic acid. synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033461 name: GGU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGU codon." [GOC:mah] comment: Note that in the standard genetic code, GGT codes for glycine. synonym: "GGT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033462 name: GGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGC codon." [GOC:mah] comment: Note that in the standard genetic code, GGC codes for glycine. synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033463 name: GGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGA codon." [GOC:mah] comment: Note that in the standard genetic code, GGA codes for glycine. synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033464 name: GGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGG codon." [GOC:mah] comment: Note that in the standard genetic code, GGG codes for glycine. synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033465 name: cis-zeatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:12800, GOC:mah] subset: gosubset_prok synonym: "cis-zeatin anabolism" EXACT [] synonym: "cis-zeatin biosynthesis" EXACT [] synonym: "cis-zeatin formation" EXACT [] synonym: "cis-zeatin synthesis" EXACT [] xref: MetaCyc:PWY-2781 is_a: GO:0033398 ! zeatin biosynthetic process is_a: GO:0033399 ! cis-zeatin metabolic process [Term] id: GO:0033466 name: trans-zeatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:16522, GOC:mah] subset: gosubset_prok synonym: "trans-zeatin anabolism" EXACT [] synonym: "trans-zeatin biosynthesis" EXACT [] synonym: "trans-zeatin formation" EXACT [] synonym: "trans-zeatin synthesis" EXACT [] xref: MetaCyc:PWY-2681 is_a: GO:0033398 ! zeatin biosynthetic process is_a: GO:0033400 ! trans-zeatin metabolic process [Term] id: GO:0033467 name: CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111] synonym: "CMP-KDO metabolic process" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT [] synonym: "CMP-ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0046400 ! keto-3-deoxy-D-manno-octulosonic acid metabolic process [Term] id: GO:0033468 name: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111] subset: gosubset_prok synonym: "CMP-KDO biosynthesis" EXACT [] synonym: "CMP-KDO biosynthetic process" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid formation" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT [] synonym: "CMP-ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732] xref: MetaCyc:KDOSYN-PWY xref: MetaCyc:PWY-1269 xref: MetaCyc:PWY-5111 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0019294 ! keto-3-deoxy-D-manno-octulosonic acid biosynthetic process is_a: GO:0033467 ! CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process [Term] id: GO:0033469 name: gibberellin 12 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [CHEBI:30088, GOC:mah] synonym: "GA12 metabolic process" EXACT [] synonym: "gibberellin 12 metabolism" EXACT [] synonym: "gibberellin A12 metabolic process" EXACT [] is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0033470 name: gibberellin 12 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [CHEBI:30088, GOC:mah] synonym: "GA12 biosynthetic process" EXACT [] synonym: "gibberellin 12 anabolism" EXACT [] synonym: "gibberellin 12 biosynthesis" EXACT [] synonym: "gibberellin 12 formation" EXACT [] synonym: "gibberellin 12 synthesis" EXACT [] synonym: "gibberellin A12 biosynthetic process" EXACT [] xref: MetaCyc:PWY-5034 is_a: GO:0009686 ! gibberellin biosynthetic process is_a: GO:0033469 ! gibberellin 12 metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0033471 name: GDP-L-galactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah] synonym: "GDP-L-galactose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0033472 name: GDP-L-galactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah] synonym: "GDP-L-galactose anabolism" EXACT [] synonym: "GDP-L-galactose biosynthesis" EXACT [] synonym: "GDP-L-galactose formation" EXACT [] synonym: "GDP-L-galactose synthesis" EXACT [] xref: MetaCyc:PWY-5115 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033471 ! GDP-L-galactose metabolic process [Term] id: GO:0033473 name: indoleacetic acid conjugate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah] synonym: "IAA conjugate metabolic process" EXACT [] synonym: "indole acetic acid conjugate metabolic process" EXACT [] synonym: "indole acetic acid conjugate metabolism" EXACT [] synonym: "indoleacetic acid conjugate metabolism" EXACT [] is_a: GO:0009683 ! indoleacetic acid metabolic process [Term] id: GO:0033474 name: indoleacetic acid conjugate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah] synonym: "IAA conjugate biosynthetic process" EXACT [] synonym: "indole acetic acid conjugate biosynthesis" EXACT [] synonym: "indole acetic acid conjugate biosynthetic process" EXACT [] synonym: "indoleacetic acid conjugate anabolism" EXACT [] synonym: "indoleacetic acid conjugate biosynthesis" EXACT [] synonym: "indoleacetic acid conjugate formation" EXACT [] synonym: "indoleacetic acid conjugate synthesis" EXACT [] is_a: GO:0009851 ! auxin biosynthetic process is_a: GO:0033473 ! indoleacetic acid conjugate metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process [Term] id: GO:0033475 name: indoleacetic acid amide conjugate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond." [GOC:mah, MetaCyc:PWY-1782] synonym: "IAA amide conjugate biosynthetic process" EXACT [] synonym: "indole acetic acid amide conjugate biosynthesis" EXACT [] synonym: "indole acetic acid amide conjugate biosynthetic process" EXACT [] synonym: "indoleacetic acid amide conjugate anabolism" EXACT [] synonym: "indoleacetic acid amide conjugate biosynthesis" EXACT [] synonym: "indoleacetic acid amide conjugate formation" EXACT [] synonym: "indoleacetic acid amide conjugate synthesis" EXACT [] xref: MetaCyc:PWY-1782 is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process [Term] id: GO:0033476 name: indoleacetic acid ester conjugate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond." [GOC:mah, MetaCyc:PWY-1741] synonym: "IAA ester conjugate biosynthetic process" EXACT [] synonym: "indole acetic acid ester conjugate biosynthesis" EXACT [] synonym: "indole acetic acid ester conjugate biosynthetic process" EXACT [] synonym: "indoleacetic acid ester conjugate anabolism" EXACT [] synonym: "indoleacetic acid ester conjugate biosynthesis" EXACT [] synonym: "indoleacetic acid ester conjugate formation" EXACT [] synonym: "indoleacetic acid ester conjugate synthesis" EXACT [] xref: MetaCyc:PWY-1741 is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process [Term] id: GO:0033477 name: S-methylmethionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [GOC:mah, PMID:12692340] synonym: "S-methylmethionine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0033478 name: UDP-rhamnose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [GOC:mah, PMID:15134748] synonym: "UDP-rhamnose metabolism" EXACT [] xref: MetaCyc:PWY-3261 is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0033479 name: UDP-D-galacturonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-D-galacturonate metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0046396 ! D-galacturonate metabolic process [Term] id: GO:0033480 name: UDP-D-galacturonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-D-galacturonate anabolism" EXACT [] synonym: "UDP-D-galacturonate biosynthesis" EXACT [] synonym: "UDP-D-galacturonate formation" EXACT [] synonym: "UDP-D-galacturonate synthesis" EXACT [] xref: MetaCyc:PWY-4 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033479 ! UDP-D-galacturonate metabolic process is_a: GO:0033482 ! D-galacturonate biosynthetic process [Term] id: GO:0033481 name: galacturonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid." [GOC:mah] synonym: "galacturonate anabolism" EXACT [] synonym: "galacturonate biosynthesis" EXACT [] synonym: "galacturonate formation" EXACT [] synonym: "galacturonate synthesis" EXACT [] is_a: GO:0019586 ! galacturonate metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0033482 name: D-galacturonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:jsg, GOC:mah] synonym: "D-galacturonate anabolism" EXACT [] synonym: "D-galacturonate biosynthesis" EXACT [] synonym: "D-galacturonate formation" EXACT [] synonym: "D-galacturonate synthesis" EXACT [] is_a: GO:0033481 ! galacturonate biosynthetic process is_a: GO:0046396 ! D-galacturonate metabolic process [Term] id: GO:0033483 name: gas homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of a gas within an organism or cell." [GOC:mah] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0033484 name: nitric oxide homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of nitric oxide within an organism or cell." [GOC:mah] synonym: "NO homeostasis" EXACT [] is_a: GO:0033483 ! gas homeostasis [Term] id: GO:0033485 name: cyanidin 3-O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125] synonym: "cyanidin 3-O-glucoside anabolism" EXACT [] synonym: "cyanidin 3-O-glucoside biosynthesis" EXACT [] synonym: "cyanidin 3-O-glucoside formation" EXACT [] synonym: "cyanidin 3-O-glucoside synthesis" EXACT [] xref: MetaCyc:PWY-5125 is_a: GO:0009718 ! anthocyanin biosynthetic process is_a: GO:0016140 ! O-glycoside metabolic process [Term] id: GO:0033486 name: delphinidin 3-O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5153] synonym: "delphinidin 3-O-glucoside anabolism" EXACT [] synonym: "delphinidin 3-O-glucoside biosynthesis" EXACT [] synonym: "delphinidin 3-O-glucoside formation" EXACT [] synonym: "delphinidin 3-O-glucoside synthesis" EXACT [] xref: MetaCyc:PWY-5153 is_a: GO:0009718 ! anthocyanin biosynthetic process is_a: GO:0016140 ! O-glycoside metabolic process [Term] id: GO:0033487 name: pelargonidin 3-O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pelargonidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125] synonym: "pelargonidin 3-O-glucoside anabolism" EXACT [] synonym: "pelargonidin 3-O-glucoside biosynthesis" EXACT [] synonym: "pelargonidin 3-O-glucoside formation" EXACT [] synonym: "pelargonidin 3-O-glucoside synthesis" EXACT [] xref: MetaCyc:PWY-5125 is_a: GO:0009718 ! anthocyanin biosynthetic process is_a: GO:0016140 ! O-glycoside metabolic process [Term] id: GO:0033488 name: cholesterol biosynthetic process via 24,25-dihydrolanosterol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol." [GOC:mah, MetaCyc:PWY66-3] synonym: "cholesterol anabolism via 24,25-dihydrolanosterol" EXACT [] synonym: "cholesterol biosynthesis via 24,25-dihydrolanosterol" EXACT [] synonym: "cholesterol formation via 24,25-dihydrolanosterol" EXACT [] synonym: "cholesterol synthesis via 24,25-dihydrolanosterol" EXACT [] xref: MetaCyc:PWY66-3 is_a: GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0033489 name: cholesterol biosynthetic process via desmosterol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol." [GOC:mah, MetaCyc:PWY66-4] synonym: "cholesterol anabolism via desmosterol" EXACT [] synonym: "cholesterol biosynthesis via desmosterol" EXACT [] synonym: "cholesterol formation via desmosterol" EXACT [] synonym: "cholesterol synthesis via desmosterol" EXACT [] xref: MetaCyc:PWY66-4 is_a: GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0033490 name: cholesterol biosynthetic process via lathosterol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341] synonym: "cholesterol anabolism via lathosterol" EXACT [] synonym: "cholesterol biosynthesis via lathosterol" EXACT [] synonym: "cholesterol formation via lathosterol" EXACT [] synonym: "cholesterol synthesis via lathosterol" EXACT [] xref: MetaCyc:PWY66-341 is_a: GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0033491 name: coniferin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coniferin, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside." [CHEBI:16220, GOC:mah, MetaCyc:PWY-116] synonym: "coniferin metabolism" EXACT [] xref: MetaCyc:PWY-116 is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0033492 name: esculetin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving esculetin, 6,7-dihydroxycoumarin." [GOC:mah] synonym: "esculetin metabolism" EXACT [] is_a: GO:0009804 ! coumarin metabolic process [Term] id: GO:0033493 name: esculetin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of esculetin, 6,7-dihydroxycoumarin." [GOC:mah] synonym: "esculetin anabolism" EXACT [] synonym: "esculetin biosynthesis" EXACT [] synonym: "esculetin formation" EXACT [] synonym: "esculetin synthesis" EXACT [] xref: MetaCyc:PWY-5349 is_a: GO:0009805 ! coumarin biosynthetic process is_a: GO:0033492 ! esculetin metabolic process [Term] id: GO:0033494 name: ferulate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [CHEBI:29749, GOC:mah] synonym: "ferulate metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0033495 name: ferulate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [CHEBI:29749, GOC:mah] synonym: "ferulate anabolism" EXACT [] synonym: "ferulate biosynthesis" EXACT [] synonym: "ferulate formation" EXACT [] synonym: "ferulate synthesis" EXACT [] xref: MetaCyc:PWY-5168 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0033494 ! ferulate metabolic process [Term] id: GO:0033496 name: sinapate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [CHEBI:30023, GOC:mah] synonym: "sinapate metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0033497 name: sinapate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [CHEBI:30023, GOC:mah] synonym: "sinapate anabolism" EXACT [] synonym: "sinapate biosynthesis" EXACT [] synonym: "sinapate formation" EXACT [] synonym: "sinapate synthesis" EXACT [] xref: MetaCyc:PWY-5168 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0033496 ! sinapate metabolic process [Term] id: GO:0033498 name: galactose catabolic process via D-galactonate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate." [GOC:mah, MetaCyc:GALDEG-PWY] subset: gosubset_prok synonym: "galactose breakdown via D-galactonate" EXACT [] synonym: "galactose catabolism via D-galactonate" EXACT [] synonym: "galactose degradation via D-galactonate" EXACT [] xref: MetaCyc:GALDEG-PWY is_a: GO:0019388 ! galactose catabolic process [Term] id: GO:0033499 name: galactose catabolic process via UDP-galactose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821] synonym: "galactose breakdown via UDP-galactose" EXACT [] synonym: "galactose catabolism via UDP-galactose" EXACT [] synonym: "galactose degradation via UDP-galactose" EXACT [] xref: MetaCyc:PWY-3821 is_a: GO:0019388 ! galactose catabolic process [Term] id: GO:0033500 name: carbohydrate homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] subset: gosubset_prok is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0033501 name: galactose homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of galactose within an organism or cell." [GOC:mah] is_a: GO:0033500 ! carbohydrate homeostasis [Term] id: GO:0033502 name: cellular galactose homeostasis namespace: biological_process def: "A cellular homeostatic process involved in the maintenance of an internal steady state of galactose within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] subset: gosubset_prok synonym: "cell galactose homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0033501 ! galactose homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0033503 name: HULC complex namespace: cellular_component def: "A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2." [GOC:mah, PMID:17363370, PMID:17374714] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0031371 ! ubiquitin conjugating enzyme complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000792 ! heterochromatin [Term] id: GO:0033504 name: floor plate development namespace: biological_process def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0033505 name: floor plate morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the floor plate is generated and organized." [GOC:dh] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0033504 ! floor plate development [Term] id: GO:0033506 name: glucosinolate biosynthetic process from homomethionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including homomethionine." [GOC:mah, MetaCyc:PWY-1187] subset: gosubset_prok synonym: "glucosinolate anabolism from homomethionine" EXACT [] synonym: "glucosinolate biosynthesis from homomethionine" EXACT [] synonym: "glucosinolate formation from homomethionine" EXACT [] synonym: "glucosinolate synthesis from homomethionine" EXACT [] xref: MetaCyc:PWY-1187 is_a: GO:0019761 ! glucosinolate biosynthetic process [Term] id: GO:0033507 name: glucosinolate biosynthetic process from phenylalanine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including phenylalanine." [GOC:mah, MetaCyc:PWY-2821] subset: gosubset_prok synonym: "glucosinolate anabolism from phenylalanine" EXACT [] synonym: "glucosinolate biosynthesis from phenylalanine" EXACT [] synonym: "glucosinolate formation from phenylalanine" EXACT [] synonym: "glucosinolate synthesis from phenylalanine" EXACT [] xref: MetaCyc:PWY-2821 is_a: GO:0019761 ! glucosinolate biosynthetic process [Term] id: GO:0033508 name: glutamate catabolic process to butyrate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate." [GOC:mah, MetaCyc:PWY-5087] subset: gosubset_prok synonym: "glutamate breakdown to butyrate" EXACT [] synonym: "glutamate degradation to butyrate" EXACT [] xref: MetaCyc:PWY-5087 is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0019605 ! butyrate metabolic process [Term] id: GO:0033509 name: glutamate catabolic process to propionate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including propionate." [GOC:mah, MetaCyc:PWY-5088] subset: gosubset_prok synonym: "glutamate breakdown to propionate" EXACT [] synonym: "glutamate degradation to propionate" EXACT [] xref: MetaCyc:PWY-5088 is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0019541 ! propionate metabolic process [Term] id: GO:0033510 name: luteolin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [CHEBI:15864, GOC:mah] synonym: "luteolin metabolism" EXACT [] is_a: GO:0051552 ! flavone metabolic process [Term] id: GO:0033511 name: luteolin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [CHEBI:15864, GOC:mah] synonym: "luteolin anabolism" EXACT [] synonym: "luteolin biosynthesis" EXACT [] synonym: "luteolin formation" EXACT [] synonym: "luteolin synthesis" EXACT [] xref: MetaCyc:PWY-5060 is_a: GO:0033510 ! luteolin metabolic process is_a: GO:0051553 ! flavone biosynthetic process [Term] id: GO:0033512 name: L-lysine catabolic process to acetyl-CoA via saccharopine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine." [GOC:mah, MetaCyc:LYSINE-DEG1-PWY] subset: gosubset_prok synonym: "L-lysine breakdown to acetyl-CoA via saccharopine" EXACT [] synonym: "L-lysine degradation to acetyl-CoA via saccharopine" EXACT [] xref: MetaCyc:LYSINE-DEG1-PWY is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA [Term] id: GO:0033513 name: L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide." [GOC:mah, MetaCyc:PWY-5280] subset: gosubset_prok synonym: "L-lysine breakdown to acetyl-CoA via 5-aminopentanamide" EXACT [] synonym: "L-lysine degradation to acetyl-CoA via 5-aminopentanamide" EXACT [] xref: MetaCyc:PWY-5280 is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA [Term] id: GO:0033514 name: L-lysine catabolic process to acetyl-CoA via L-pipecolate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate." [GOC:mah, MetaCyc:PWY-5283] subset: gosubset_prok synonym: "L-lysine breakdown to acetyl-CoA via L-pipecolate" EXACT [] synonym: "L-lysine degradation to acetyl-CoA via L-pipecolate" EXACT [] xref: MetaCyc:PWY-5283 is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA [Term] id: GO:0033515 name: L-lysine catabolic process using lysine 6-aminotransferase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase." [GOC:mah, MetaCyc:PWY-5298] subset: gosubset_prok synonym: "L-lysine breakdown using lysine 6-aminotransferase" EXACT [GOC:mah] synonym: "L-lysine degradation using lysine 6-aminotransferase" EXACT [GOC:mah] xref: MetaCyc:PWY-5298 is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA [Term] id: GO:0033516 name: L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine." [GOC:mah, MetaCyc:PWY-702] subset: gosubset_prok synonym: "L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] xref: MetaCyc:PWY-702 is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine [Term] id: GO:0033517 name: myo-inositol hexakisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [CHEBI:17401, PMID:16107538] synonym: "myo-inositol hexakisphosphate metabolism" EXACT [] synonym: "phytate metabolic process" EXACT [] synonym: "phytate metabolism" EXACT [] is_a: GO:0043647 ! inositol phosphate metabolic process [Term] id: GO:0033518 name: myo-inositol hexakisphosphate dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate group from myo-inositol hexakisphosphate." [GOC:mah] synonym: "phytate dephosphorylation" EXACT [] xref: MetaCyc:PWY-4702 xref: MetaCyc:PWY-4781 is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process is_a: GO:0046855 ! inositol phosphate dephosphorylation [Term] id: GO:0033519 name: phytyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [CHEBI:18187, GOC:mah] synonym: "phytyl diphosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0033520 name: phytol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [CHEBI:17327, GOC:mah] synonym: "phytol anabolism" EXACT [] synonym: "phytol biosynthesis" EXACT [] synonym: "phytol formation" EXACT [] synonym: "phytol synthesis" EXACT [] is_a: GO:0033306 ! phytol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0033521 name: phytyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [CHEBI:18187, GOC:mah] synonym: "phytyl diphosphate anabolism" EXACT [] synonym: "phytyl diphosphate biosynthesis" EXACT [] synonym: "phytyl diphosphate formation" EXACT [] synonym: "phytyl diphosphate synthesis" EXACT [] xref: MetaCyc:PWY-5063 is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0033519 ! phytyl diphosphate metabolic process [Term] id: GO:0033522 name: histone H2A ubiquitination namespace: biological_process def: "The modification of histone H2A by addition of one or more ubiquitin groups." [GOC:bf, GOC:mah, PMID:15509584, PMID:16473935, PMID:18430235] is_a: GO:0016574 ! histone ubiquitination [Term] id: GO:0033523 name: histone H2B ubiquitination namespace: biological_process def: "The modification of histone H2B by addition of ubiquitin groups." [GOC:mah] is_a: GO:0016574 ! histone ubiquitination [Term] id: GO:0033524 name: sinapate ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ester derivatives of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [CHEBI:30023, GOC:mah] synonym: "sinapate ester metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0033525 name: sinapate ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [CHEBI:30023, GOC:mah] synonym: "sinapate ester anabolism" EXACT [] synonym: "sinapate ester biosynthesis" EXACT [] synonym: "sinapate ester formation" EXACT [] synonym: "sinapate ester synthesis" EXACT [] xref: MetaCyc:PWY-3301 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0033524 ! sinapate ester metabolic process [Term] id: GO:0033526 name: tetrapyrrole biosynthetic process from glutamate namespace: biological_process def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate." [CHEBI:26932, GOC:mah, MetaCyc:PWY-5188] synonym: "tetrapyrrole anabolism from glutamate" EXACT [] synonym: "tetrapyrrole biosynthesis from glutamate" EXACT [] synonym: "tetrapyrrole formation from glutamate" EXACT [] synonym: "tetrapyrrole synthesis from glutamate" EXACT [] xref: MetaCyc:PWY-5188 is_a: GO:0033014 ! tetrapyrrole biosynthetic process [Term] id: GO:0033527 name: tetrapyrrole biosynthetic process from glycine and succinyl-CoA namespace: biological_process def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA." [CHEBI:26932, GOC:mah, MetaCyc:PWY-5189] synonym: "tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [] synonym: "tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [] synonym: "tetrapyrrole formation from glycine and succinyl-CoA" EXACT [] synonym: "tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [] xref: MetaCyc:PWY-5189 is_a: GO:0033014 ! tetrapyrrole biosynthetic process [Term] id: GO:0033528 name: S-methylmethionine cycle namespace: biological_process def: "A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441] xref: MetaCyc:PWY-5441 is_a: GO:0033477 ! S-methylmethionine metabolic process [Term] id: GO:0033529 name: raffinose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:16634, GOC:mah] synonym: "raffinose anabolism" EXACT [] synonym: "raffinose biosynthesis" EXACT [] synonym: "raffinose formation" EXACT [] synonym: "raffinose synthesis" EXACT [] is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process is_a: GO:0033530 ! raffinose metabolic process [Term] id: GO:0033530 name: raffinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:16634, GOC:mah] synonym: "raffinose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process [Term] id: GO:0033531 name: stachyose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:17164, GOC:mah] synonym: "stachyose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process [Term] id: GO:0033532 name: stachyose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:17164, GOC:mah] synonym: "stachyose anabolism" EXACT [] synonym: "stachyose biosynthesis" EXACT [] synonym: "stachyose formation" EXACT [] synonym: "stachyose synthesis" EXACT [] xref: MetaCyc:PWY-5337 is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process is_a: GO:0033531 ! stachyose metabolic process [Term] id: GO:0033533 name: verbascose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065] synonym: "verbascose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process [Term] id: GO:0033534 name: verbascose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065] synonym: "verbascose anabolism" EXACT [] synonym: "verbascose biosynthesis" EXACT [] synonym: "verbascose formation" EXACT [] synonym: "verbascose synthesis" EXACT [] is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process is_a: GO:0033533 ! verbascose metabolic process [Term] id: GO:0033535 name: ajugose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066] synonym: "ajugose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process [Term] id: GO:0033536 name: ajugose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066] synonym: "ajugose anabolism" EXACT [] synonym: "ajugose biosynthesis" EXACT [] synonym: "ajugose formation" EXACT [] synonym: "ajugose synthesis" EXACT [] is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process is_a: GO:0033535 ! ajugose metabolic process [Term] id: GO:0033537 name: ajugose biosynthetic process using galactinol:raffinose galactosyltransferase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide." [GOC:mah, MetaCyc:PWY-5342] synonym: "ajugose anabolism using galactinol:raffinose galactosyltransferase" EXACT [] synonym: "ajugose biosynthesis using galactinol:raffinose galactosyltransferase" EXACT [] synonym: "ajugose formation using galactinol:raffinose galactosyltransferase" EXACT [] synonym: "ajugose synthesis using galactinol:raffinose galactosyltransferase" EXACT [] xref: MetaCyc:PWY-5342 is_a: GO:0033536 ! ajugose biosynthetic process [Term] id: GO:0033538 name: ajugose biosynthetic process using galactan:galactan galactosyltransferase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another." [GOC:mah, MetaCyc:PWY-5343] synonym: "ajugose anabolism using galactan:galactan galactosyltransferase" EXACT [] synonym: "ajugose biosynthesis using galactan:galactan galactosyltransferase" EXACT [] synonym: "ajugose formation using galactan:galactan galactosyltransferase" EXACT [] synonym: "ajugose synthesis using galactan:galactan galactosyltransferase" EXACT [] xref: MetaCyc:PWY-5343 is_a: GO:0033536 ! ajugose biosynthetic process [Term] id: GO:0033539 name: fatty acid beta-oxidation using acyl-CoA dehydrogenase namespace: biological_process def: "A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136] xref: MetaCyc:FAO-PWY is_a: GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0033540 name: fatty acid beta-oxidation using acyl-CoA oxidase namespace: biological_process def: "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136] xref: MetaCyc:PWY-5136 xref: Reactome:1253675 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1253682 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1280607 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1280614 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1299438 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1299445 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1327192 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1327199 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1353287 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1353294 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1373464 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1373470 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1393485 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1393491 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1417985 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1417992 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1451072 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1451079 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1471430 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1471437 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1483381 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1483387 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1497045 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1497051 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1514432 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1514438 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1521295 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1521301 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1527010 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1527011 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1538091 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1538092 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1539363 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:1539364 "Beta-oxidation of very long chain fatty acids" xref: Reactome:1540371 "Beta-oxidation of very long chain fatty acids" xref: Reactome:389887 "Beta-oxidation of pristanoyl-CoA" xref: Reactome:390247 "Beta-oxidation of very long chain fatty acids" is_a: GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0033541 name: fatty acid beta-oxidation, unsaturated, odd number namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5137] xref: MetaCyc:PWY-5137 is_a: GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0033542 name: fatty acid beta-oxidation, unsaturated, even number namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] xref: MetaCyc:PWY-5138 is_a: GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0033543 name: fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number [Term] id: GO:0033544 name: fatty acid beta-oxidation, unsaturated, even number, epimerase pathway namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number [Term] id: GO:0033545 name: myo-inositol hexakisphosphate biosynthetic process, lipid-dependent namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C." [GOC:mah, MetaCyc:PWY-6555] synonym: "myo-inositol hexakisphosphate anabolism, lipid-dependent" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-dependent" EXACT [] synonym: "myo-inositol hexakisphosphate formation, lipid-dependent" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis, lipid-dependent" EXACT [] synonym: "phytate biosynthesis, lipid-dependent" EXACT [] synonym: "phytate biosynthetic process, lipid-dependent" EXACT [] xref: MetaCyc:PWY-6555 is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process [Term] id: GO:0033546 name: myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further." [GOC:mah, MetaCyc:PWY-6554] synonym: "myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "phytate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "phytate biosynthetic process, via inositol 1,3,4-trisphosphate" EXACT [] xref: MetaCyc:PWY-6554 is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent [Term] id: GO:0033547 name: myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1D myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is successively phosphorylated to yield inositol hexakisphosphate." [GOC:mah, MetaCyc:PWY-4541] synonym: "myo-inositol hexakisphosphate anabolism, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate formation, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "phytate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "phytate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] xref: MetaCyc:PWY-4541 is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent [Term] id: GO:0033548 name: myo-inositol hexakisphosphate biosynthetic process, lipid-independent namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate." [GOC:mah, MetaCyc:PWY-4661] synonym: "myo-inositol hexakisphosphate anabolism, lipid-independent" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-independent" EXACT [] synonym: "myo-inositol hexakisphosphate formation, lipid-independent" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis, lipid-independent" EXACT [] synonym: "phytate biosynthesis, lipid-independent" EXACT [] synonym: "phytate biosynthetic process, lipid-independent" EXACT [] xref: MetaCyc:PWY-4661 is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process [Term] id: GO:0033549 name: MAP kinase phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah] is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0033550 name: MAP kinase tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate." [GOC:mah] synonym: "tyrosine-specific MAP kinase phosphatase activity" EXACT [] is_a: GO:0004725 ! protein tyrosine phosphatase activity is_a: GO:0033549 ! MAP kinase phosphatase activity [Term] id: GO:0033551 name: monopolin complex namespace: cellular_component def: "A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits." [GOC:mah, GOC:rb, PMID:17627824] synonym: "monopolin subcomplex Csm1/Lrs4" NARROW [] synonym: "Pcs1/Mde4 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0033552 name: response to vitamin B3 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:sl] synonym: "response to niacin" NARROW [] synonym: "response to nicotinamide" NARROW [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0033553 name: rDNA heterochromatin namespace: cellular_component def: "A region of heterochromatin located at the rDNA repeats in a chromosome." [GOC:mah] synonym: "ribosomal DNA heterochromatin" EXACT [] is_a: GO:0000792 ! heterochromatin [Term] id: GO:0033554 name: cellular response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] subset: goslim_pombe is_a: GO:0006950 ! response to stress is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0033555 name: multicellular organismal response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] is_a: GO:0006950 ! response to stress is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0033556 name: dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol." [GOC:mah, PMID:10336995] synonym: "dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: EC:2.4.1.- is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033557 name: Slx1-Slx4 complex namespace: cellular_component def: "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0033558 name: protein deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate." [GOC:mah] is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0033559 name: unsaturated fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah] subset: gosubset_prok synonym: "unsaturated fatty acid metabolism" EXACT [] xref: MetaCyc:PWY-762 xref: MetaCyc:PWY-782 is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0033560 name: folate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pde] subset: gosubset_prok xref: Reactome:201093 "folate reductase activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0033561 name: regulation of water loss via skin namespace: biological_process def: "A process that modulates the rate or extent of water loss from an organism via the skin." [GOC:mah] synonym: "skin barrier function" RELATED [] is_a: GO:0050891 ! multicellular organismal water homeostasis [Term] id: GO:0033562 name: cotranscriptional gene silencing by small RNA namespace: biological_process def: "A process in which the targeting of nascent transcripts by the RITS complex mediates chromatin modifications and promotes the degradation of nascent transcripts synthesized in heterochromatic regions." [GOC:mah, PMID:17512405] synonym: "small RNA-mediated cotranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0031047 ! gene silencing by RNA [Term] id: GO:0033563 name: dorsal/ventral axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:kmv, GOC:tb] synonym: "dorsal-ventral axon guidance" EXACT [GOC:mah] synonym: "dorsal/ventral axon pathfinding" EXACT [GOC:mah] synonym: "dorsoventral axon guidance" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance [Term] id: GO:0033564 name: anterior/posterior axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:kmv, GOC:tb] synonym: "anterior-posterior axon guidance" EXACT [] synonym: "anterior/posterior axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance [Term] id: GO:0033565 name: ESCRT-0 complex namespace: cellular_component def: "A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals." [GOC:rb, PMID:12055639, PMID:17543868] synonym: "Hrs/STAM complex" EXACT [] synonym: "Vps27p-Hse1p complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044440 ! endosomal part [Term] id: GO:0033566 name: gamma-tubulin complex localization namespace: biological_process def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of gamma-tubulin complex localization" EXACT [] synonym: "gamma-tubulin complex localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization [Term] id: GO:0033567 name: DNA replication, Okazaki fragment processing namespace: biological_process def: "The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand." [GOC:mah, ISBN:0716720094] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006273 ! lagging strand elongation [Term] id: GO:0033568 name: lactoferrin receptor activity namespace: molecular_function def: "Combining with lactoferrin to initiate a change in cell activity." [GOC:mlg] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0033569 name: lactoferrin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg] is_a: GO:0015091 ! ferric iron transmembrane transporter activity is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: GO:0033570 name: transferrin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of transferrin from one side of a membrane to the other." [GOC:mlg] is_a: GO:0015091 ! ferric iron transmembrane transporter activity is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: GO:0033571 name: lactoferrin transport namespace: biological_process def: "The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] is_a: GO:0015031 ! protein transport is_a: GO:0015682 ! ferric iron transport [Term] id: GO:0033572 name: transferrin transport namespace: biological_process def: "The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] synonym: "melanotransferrin transport" EXACT [PRO:000001887] xref: Reactome:917977 "Transferrin endocytosis and recycling" is_a: GO:0015031 ! protein transport is_a: GO:0015682 ! ferric iron transport [Term] id: GO:0033573 name: high affinity iron permease complex namespace: cellular_component def: "A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell." [GOC:jp, PMID:16522632, PMID:8599111] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0033574 name: response to testosterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl] is_a: GO:0048545 ! response to steroid hormone stimulus [Term] id: GO:0033575 name: protein glycosylation at cell surface namespace: biological_process def: "The addition of a sugar unit to a protein amino acid at the surface of a cell." [GOC:mah, PMID:12042244] synonym: "protein amino acid glycosylation at cell surface" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0033576 name: protein glycosylation in cytosol namespace: biological_process def: "The addition of a sugar unit to a protein amino acid in the cytosol." [GOC:mah, PMID:12042244] synonym: "protein amino acid glycosylation in cytosol" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0033577 name: protein glycosylation in endoplasmic reticulum namespace: biological_process def: "The addition of a sugar unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah, PMID:12042244] synonym: "core glycosylation" RELATED [PMID:6345657] synonym: "protein amino acid glycosylation in endoplasmic reticulum" EXACT [GOC:bf] synonym: "protein amino acid glycosylation in ER" EXACT [] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0033578 name: protein glycosylation in Golgi namespace: biological_process def: "The addition of a sugar unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah, PMID:12042244] synonym: "protein amino acid glycosylation in Golgi" EXACT [GOC:bf] synonym: "terminal glycosylation" NARROW [PMID:6345657] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0033579 name: protein galactosylation in endoplasmic reticulum namespace: biological_process def: "The addition of a galactose unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah] synonym: "protein amino acid galactosylation in endoplasmic reticulum" EXACT [GOC:bf] synonym: "protein amino acid galactosylation in ER" EXACT [] is_a: GO:0033577 ! protein glycosylation in endoplasmic reticulum is_a: GO:0042125 ! protein galactosylation [Term] id: GO:0033580 name: protein galactosylation at cell surface namespace: biological_process def: "The addition of a galactose unit to a protein amino acid at the surface of a cell." [GOC:mah] synonym: "protein amino acid galactosylation at cell surface" EXACT [GOC:bf] is_a: GO:0033575 ! protein glycosylation at cell surface is_a: GO:0042125 ! protein galactosylation [Term] id: GO:0033581 name: protein galactosylation in Golgi namespace: biological_process def: "The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah] synonym: "protein amino acid galactosylation in Golgi" EXACT [GOC:bf] is_a: GO:0033578 ! protein glycosylation in Golgi is_a: GO:0042125 ! protein galactosylation [Term] id: GO:0033582 name: protein galactosylation in cytosol namespace: biological_process def: "The addition of a galactose unit to a protein amino acid in the cytosol." [GOC:mah] synonym: "protein amino acid galactosylation in cytosol" EXACT [GOC:bf] is_a: GO:0033576 ! protein glycosylation in cytosol is_a: GO:0042125 ! protein galactosylation [Term] id: GO:0033583 name: rhabdomere membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the rhabdomere." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0016028 ! rhabdomere [Term] id: GO:0033584 name: tyrosine biosynthetic process from chorismate via L-arogenate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:mah, MetaCyc:PWY-3461] subset: gosubset_prok synonym: "tyrosine anabolism from chorismate via L-arogenate" EXACT [] synonym: "tyrosine formation from chorismate via L-arogenate" EXACT [] synonym: "tyrosine synthesis from chorismate via L-arogenate" EXACT [] xref: MetaCyc:PWY-3461 is_a: GO:0006571 ! tyrosine biosynthetic process [Term] id: GO:0033585 name: L-phenylalanine biosynthetic process from chorismate via phenylpyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate." [GOC:go_curators] subset: gosubset_prok synonym: "L-phenylalanine anabolism from chorismate via phenylpyruvate" EXACT [] synonym: "L-phenylalanine biosynthesis from chorismate via phenylpyruvate" EXACT [] synonym: "L-phenylalanine formation from chorismate via phenylpyruvate" EXACT [] synonym: "L-phenylalanine synthesis from chorismate via phenylpyruvate" EXACT [] xref: MetaCyc:PHESYN is_a: GO:0009094 ! L-phenylalanine biosynthetic process [Term] id: GO:0033586 name: L-phenylalanine biosynthetic process from chorismate via L-arogenate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:go_curators] subset: gosubset_prok synonym: "L-phenylalanine anabolism from chorismate via L-arogenate" EXACT [] synonym: "L-phenylalanine biosynthesis from chorismate via L-arogenate" EXACT [] synonym: "L-phenylalanine formation from chorismate via L-arogenate" EXACT [] synonym: "L-phenylalanine synthesis from chorismate via L-arogenate" EXACT [] xref: MetaCyc:PWY-3462 is_a: GO:0009094 ! L-phenylalanine biosynthetic process [Term] id: GO:0033587 name: shikimate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [CHEBI:36208, GOC:mah] synonym: "shikimate anabolism" EXACT [] synonym: "shikimate biosynthesis" EXACT [] synonym: "shikimate formation" EXACT [] synonym: "shikimate synthesis" EXACT [] is_a: GO:0019632 ! shikimate metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0033588 name: Elongator holoenzyme complex namespace: cellular_component alt_id: GO:0033589 def: "A heterohexameric protein complex that is involved in tRNA modification, and exerts indirect effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes." [GOC:mah, PMID:11689709, PMID:17018299] synonym: "Elongator core complex" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0033590 name: response to cobalamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:sl] synonym: "response to vitamin B12" EXACT [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0033591 name: response to L-ascorbic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:sl] synonym: "response to ascorbic acid" BROAD [] synonym: "response to L-ascorbate" EXACT [] synonym: "response to vitamin C" EXACT [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0033592 name: RNA strand annealing activity namespace: molecular_function def: "Facilitates the base-pairing of complementary single-stranded RNA." [GOC:mah] is_a: GO:0003725 ! double-stranded RNA binding is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0033593 name: BRCA2-MAGE-D1 complex namespace: cellular_component def: "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0033594 name: response to hydroxyisoflavone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [CHEBI:38755, GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0033595 name: response to genistein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [CHEBI:28088, GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0033596 name: TSC1-TSC2 complex namespace: cellular_component def: "A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671] synonym: "tuberin-hamartin complex " EXACT [] synonym: "tuberous sclerosis complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0033597 name: mitotic checkpoint complex namespace: cellular_component def: "A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20." [PMID:10704439, PMID:11535616, PMID:11726501, PMID:17650307] synonym: "MCC" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0033598 name: mammary gland epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah] is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0061180 ! mammary gland epithelium development [Term] id: GO:0033599 name: regulation of mammary gland epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] is_a: GO:0050678 ! regulation of epithelial cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0033598 ! mammary gland epithelial cell proliferation [Term] id: GO:0033600 name: negative regulation of mammary gland epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] synonym: "down regulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "down-regulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "downregulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "inhibition of mammary gland epithelial cell proliferation" NARROW [] is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation relationship: negatively_regulates GO:0033598 ! mammary gland epithelial cell proliferation [Term] id: GO:0033601 name: positive regulation of mammary gland epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] synonym: "activation of mammary gland epithelial cell proliferation" NARROW [] synonym: "stimulation of mammary gland epithelial cell proliferation" NARROW [] synonym: "up regulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "up-regulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "upregulation of mammary gland epithelial cell proliferation" EXACT [] is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation relationship: positively_regulates GO:0033598 ! mammary gland epithelial cell proliferation [Term] id: GO:0033602 name: negative regulation of dopamine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] synonym: "down regulation of dopamine secretion" EXACT [] synonym: "down-regulation of dopamine secretion" EXACT [] synonym: "downregulation of dopamine secretion" EXACT [] synonym: "inhibition of dopamine secretion" NARROW [] is_a: GO:0014059 ! regulation of dopamine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion relationship: negatively_regulates GO:0014046 ! dopamine secretion [Term] id: GO:0033603 name: positive regulation of dopamine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] synonym: "activation of dopamine secretion" NARROW [] synonym: "stimulation of dopamine secretion" NARROW [] synonym: "up regulation of dopamine secretion" EXACT [] synonym: "up-regulation of dopamine secretion" EXACT [] synonym: "upregulation of dopamine secretion" EXACT [] is_a: GO:0014059 ! regulation of dopamine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion relationship: positively_regulates GO:0014046 ! dopamine secretion [Term] id: GO:0033604 name: negative regulation of catecholamine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "down regulation of catecholamine secretion" EXACT [] synonym: "down-regulation of catecholamine secretion" EXACT [] synonym: "downregulation of catecholamine secretion" EXACT [] synonym: "inhibition of catecholamine secretion" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051953 ! negative regulation of amine transport relationship: negatively_regulates GO:0050432 ! catecholamine secretion [Term] id: GO:0033605 name: positive regulation of catecholamine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "activation of catecholamine secretion" NARROW [] synonym: "stimulation of catecholamine secretion" NARROW [] synonym: "up regulation of catecholamine secretion" EXACT [] synonym: "up-regulation of catecholamine secretion" EXACT [] synonym: "upregulation of catecholamine secretion" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051954 ! positive regulation of amine transport relationship: positively_regulates GO:0050432 ! catecholamine secretion [Term] id: GO:0033606 name: chemokine receptor transport within lipid bilayer namespace: biological_process def: "The directed movement of a chemokine receptor within a lipid bilayer." [GOC:mah] synonym: "chemokine receptor translocation within membrane" EXACT [] is_a: GO:0032594 ! protein transport within lipid bilayer [Term] id: GO:0033607 name: SOD1-Bcl-2 complex namespace: cellular_component def: "A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway." [PMID:15233914, PMID:16790527] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0033608 name: formyl-CoA transferase activity namespace: molecular_function def: "Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA." [EC:2.8.3.16, RHEA:16548] synonym: "formyl-CoA oxalate CoA-transferase activity" EXACT [EC:2.8.3.16] synonym: "formyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.16] synonym: "formyl-coenzyme A transferase activity" EXACT [EC:2.8.3.16] xref: EC:2.8.3.16 xref: KEGG:R07290 xref: MetaCyc:RXN0-1382 xref: RHEA:16548 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0033609 name: oxalate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxalate, the organic acid ethanedioate." [CHEBI:30623, GOC:mlg] synonym: "ethanedioate metabolic process" EXACT [] synonym: "ethanedioic acid metabolic process" EXACT [] synonym: "oxalate metabolism" EXACT [] synonym: "oxalic acid metabolic process" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0033610 name: oxalate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oxalate, the organic acid ethanedioate." [CHEBI:30623, GOC:mlg] synonym: "ethanedioate biosynthetic process" EXACT [] synonym: "ethanedioic acid biosynthetic process" EXACT [] synonym: "oxalate anabolism" EXACT [] synonym: "oxalate biosynthesis" EXACT [] synonym: "oxalate formation" EXACT [] synonym: "oxalate synthesis" EXACT [] synonym: "oxalic acid biosynthetic process" EXACT [] is_a: GO:0033609 ! oxalate metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0033611 name: oxalate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate." [CHEBI:30623, GOC:mlg] synonym: "ethanedioate catabolic process" EXACT [] synonym: "ethanedioic acid catabolic process" EXACT [] synonym: "oxalate breakdown" EXACT [] synonym: "oxalate catabolism" EXACT [] synonym: "oxalate degradation" EXACT [] synonym: "oxalic acid catabolic process" EXACT [] is_a: GO:0033609 ! oxalate metabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0033612 name: receptor serine/threonine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity." [GOC:mah] synonym: "transmembrane receptor protein serine/threonine kinase ligand binding" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0033613 name: activating transcription factor binding namespace: molecular_function alt_id: GO:0001107 def: "Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription." [GOC:mah, GOC:txnOH] synonym: "transcription activator binding" EXACT [] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0033614 name: chloroplast proton-transporting ATP synthase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane." [GOC:mah] is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly relationship: part_of GO:0009658 ! chloroplast organization [Term] id: GO:0033615 name: mitochondrial proton-transporting ATP synthase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane." [GOC:mah] is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly relationship: part_of GO:0007005 ! mitochondrion organization [Term] id: GO:0033616 name: plasma membrane proton-transporting ATP synthase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane." [GOC:mah] is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly relationship: part_of GO:0007009 ! plasma membrane organization [Term] id: GO:0033617 name: mitochondrial respiratory chain complex IV assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah] subset: gosubset_prok synonym: "mitochondrial cytochrome c oxidase biogenesis" BROAD [] synonym: "mitochondrial cytochrome c oxidase complex assembly" EXACT [] is_a: GO:0008535 ! respiratory chain complex IV assembly is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly is_a: GO:0097034 ! mitochondrial respiratory chain complex IV biogenesis [Term] id: GO:0033618 name: plasma membrane respiratory chain complex IV assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane." [GOC:mah] subset: gosubset_prok synonym: "plasma membrane cytochrome c oxidase biogenesis" BROAD [] synonym: "plasma membrane cytochrome c oxidase complex assembly" EXACT [] is_a: GO:0008535 ! respiratory chain complex IV assembly relationship: part_of GO:0007009 ! plasma membrane organization [Term] id: GO:0033619 name: membrane protein proteolysis namespace: biological_process def: "The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains." [GOC:pde] subset: gosubset_prok is_a: GO:0006508 ! proteolysis [Term] id: GO:0033620 name: Mei2 nuclear dot namespace: cellular_component def: "A nuclear body that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I." [PMID:12808043] synonym: "Mei2 dot" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0033621 name: nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts namespace: biological_process def: "The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [PMID:16823445] comment: Note that it is speculated that higher eukaryotic YTH-family protein may be involved in similar mechanisms to supress gene regulation during gametogenesis or general silencing. synonym: "degradation of meiosis-specific transcripts" EXACT [] synonym: "mRNA breakdown, meiosis-specific transcripts" EXACT [] synonym: "mRNA catabolism, meiosis-specific transcripts" EXACT [] synonym: "mRNA degradation, meiosis-specific transcripts" EXACT [] synonym: "nuclear mRNA catabolic process, meiosis-specific transcripts" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0033622 name: integrin activation namespace: biological_process def: "The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902] synonym: "integrin complex activation" EXACT [] synonym: "integrin complex assembly" EXACT [] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0033623 name: regulation of integrin activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of integrin activation." [GOC:add] synonym: "regulation of integrin complex activation" EXACT [] is_a: GO:0043254 ! regulation of protein complex assembly relationship: regulates GO:0033622 ! integrin activation [Term] id: GO:0033624 name: negative regulation of integrin activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation." [GOC:add] synonym: "negative regulation of integrin complex activation" EXACT [] is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0033623 ! regulation of integrin activation relationship: negatively_regulates GO:0033622 ! integrin activation [Term] id: GO:0033625 name: positive regulation of integrin activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of integrin activation." [GOC:add] synonym: "positive regulation of integrin complex activation" EXACT [] is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0033623 ! regulation of integrin activation relationship: positively_regulates GO:0033622 ! integrin activation [Term] id: GO:0033626 name: cell surface receptor linked signal transduction leading to integrin activation namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell that lead to the increased affinity of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902] synonym: "cell surface receptor linked signal transduction leading to integrin complex activation" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0033627 name: cell adhesion mediated by integrin namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] synonym: "cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0007155 ! cell adhesion [Term] id: GO:0033628 name: regulation of cell adhesion mediated by integrin namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] synonym: "regulation of cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0030155 ! regulation of cell adhesion relationship: regulates GO:0033627 ! cell adhesion mediated by integrin [Term] id: GO:0033629 name: negative regulation of cell adhesion mediated by integrin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] synonym: "negative regulation of cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin relationship: negatively_regulates GO:0033627 ! cell adhesion mediated by integrin [Term] id: GO:0033630 name: positive regulation of cell adhesion mediated by integrin namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] synonym: "positive regulation of cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin is_a: GO:0045785 ! positive regulation of cell adhesion relationship: positively_regulates GO:0033627 ! cell adhesion mediated by integrin [Term] id: GO:0033631 name: cell-cell adhesion mediated by integrin namespace: biological_process def: "The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] synonym: "cell-cell adhesion mediated by integrin complex " EXACT [] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0033627 ! cell adhesion mediated by integrin [Term] id: GO:0033632 name: regulation of cell-cell adhesion mediated by integrin namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] synonym: "regulation of cell-cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin relationship: regulates GO:0033631 ! cell-cell adhesion mediated by integrin [Term] id: GO:0033633 name: negative regulation of cell-cell adhesion mediated by integrin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] synonym: "negative regulation of cell-cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0033629 ! negative regulation of cell adhesion mediated by integrin is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin relationship: negatively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin [Term] id: GO:0033634 name: positive regulation of cell-cell adhesion mediated by integrin namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] synonym: "positive regulation of cell-cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0033630 ! positive regulation of cell adhesion mediated by integrin is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin relationship: positively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin [Term] id: GO:0033635 name: modulation by symbiont of host response to abiotic stimulus namespace: biological_process def: "Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology [Term] id: GO:0033636 name: modulation by symbiont of host response to temperature stimulus namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "modulation by symbiont of host response to thermal stimulus" EXACT [] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus [Term] id: GO:0033637 name: modulation by symbiont of host response to cold namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "freezing tolerance" RELATED [] is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus [Term] id: GO:0033638 name: modulation by symbiont of host response to heat namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "response to heat shock" RELATED [] is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus [Term] id: GO:0033639 name: modulation by symbiont of host response to water namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus [Term] id: GO:0033640 name: modulation by symbiont of host response to osmotic stress namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus [Term] id: GO:0033641 name: modulation by symbiont of host response to pH namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus [Term] id: GO:0033642 name: modulation by symbiont of host response to gravitational stimulus namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "response to gravitational stimulus" BROAD [] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus [Term] id: GO:0033643 name: host cell part namespace: cellular_component def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0044217 ! other organism part relationship: part_of GO:0043657 ! host cell [Term] id: GO:0033644 name: host cell membrane namespace: cellular_component def: "Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0033643 ! host cell part is_a: GO:0044218 ! other organism cell membrane [Term] id: GO:0033645 name: host cell endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033644 ! host cell membrane [Term] id: GO:0033646 name: host intracellular part namespace: cellular_component def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok synonym: "host cell intracellular part" EXACT [] is_a: GO:0033643 ! host cell part relationship: part_of GO:0043656 ! intracellular region of host [Term] id: GO:0033647 name: host intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0033646 ! host intracellular part [Term] id: GO:0033648 name: host intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok synonym: "host intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0033647 ! host intracellular organelle [Term] id: GO:0033650 name: host cell mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "host mitochondria" EXACT [] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0033651 name: host cell plastid namespace: cellular_component def: "Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0033652 name: host cell chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033651 ! host cell plastid [Term] id: GO:0033653 name: host cell chloroplast part namespace: cellular_component def: "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "host chloroplast component" EXACT [] is_a: GO:0033652 ! host cell chloroplast [Term] id: GO:0033654 name: host cell chloroplast thylakoid membrane namespace: cellular_component def: "Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033653 ! host cell chloroplast part is_a: GO:0044160 ! host thylakoid membrane [Term] id: GO:0033655 name: host cell cytoplasm part namespace: cellular_component def: "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok synonym: "cytoplasm component" BROAD [] is_a: GO:0033646 ! host intracellular part relationship: part_of GO:0030430 ! host cell cytoplasm [Term] id: GO:0033656 name: modification by symbiont of host chloroplast namespace: biological_process def: "The process in which an organism effects a change in the structure or function of host cell chloroplasts. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052043 ! modification by symbiont of host cellular component [Term] id: GO:0033657 name: modification by symbiont of host chloroplast part namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033656 ! modification by symbiont of host chloroplast [Term] id: GO:0033658 name: modification by symbiont of host chloroplast thylakoid namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033657 ! modification by symbiont of host chloroplast part [Term] id: GO:0033659 name: modification by symbiont of host mitochondrion namespace: biological_process def: "The process in which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052043 ! modification by symbiont of host cellular component [Term] id: GO:0033660 name: negative regulation by symbiont of host resistance gene-dependent defense response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "down regulation by symbiont of defense response in host by specific elicitors" EXACT [] synonym: "down-regulation by symbiont of host gene-for-gene resistance" EXACT [] synonym: "downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] synonym: "inhibition by symbiont of host resistance gene-dependent defense response" NARROW [] synonym: "suppression by symbiont of host resistance gene-dependent defense response" EXACT [] is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response [Term] id: GO:0033661 name: negative regulation by symbiont of defense-related host reactive oxygen species production namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "down regulation by organism of defense-related host metabolic burst" EXACT [] synonym: "down-regulation by organism of defense-related host oxidative burst" EXACT [] synonym: "downregulation by organism of defense-related host AOS production" EXACT [] synonym: "inhibition by organism of defense-related host active oxygen species production" NARROW [] synonym: "negative regulation by organism of defense-related host reactive oxidative species production" EXACT [] synonym: "negative regulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] synonym: "negative regulation by organism of defense-related host respiratory burst" EXACT [] synonym: "negative regulation by organism of defense-related host ROI production" EXACT [] synonym: "negative regulation by organism of defense-related host ROS production" EXACT [] is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052164 ! modulation by symbiont of defense-related host reactive oxygen species production [Term] id: GO:0033662 name: modulation by symbiont of host defense-related protein level namespace: biological_process def: "The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0075344 ! modulation by symbiont of host protein levels [Term] id: GO:0033663 name: negative regulation by symbiont of host defense-related protein level namespace: biological_process def: "Any process in which the symbiont stops or reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level is_a: GO:0052037 ! negative regulation by symbiont of host defense response [Term] id: GO:0033664 name: positive regulation by symbiont of host defense-related protein level namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level is_a: GO:0052509 ! positive regulation by symbiont of host defense response [Term] id: GO:0033665 name: regulation of growth or development of symbiont in host namespace: biological_process def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:dph, GOC:pamgo_curators, GOC:tb] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'regulation of development of symbiont in host ; GO:0044127' and 'regulation of growth of symbiont in host ; GO:0044126'. synonym: "modulation of growth or development of organism within host" EXACT [] synonym: "modulation of growth or development of symbiont within host" EXACT [GOC:dph, GOC:tb] synonym: "modulation of invasive growth" BROAD [] synonym: "regulation of growth or development of symbiont within host" EXACT [] is_obsolete: true replaced_by: GO:0044126 replaced_by: GO:0044127 [Term] id: GO:0033666 name: positive regulation of growth or development of symbiont in host namespace: biological_process def: "OBSOLETE. Any process by which the symbiont activates, maintains or increases its size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont in host ; GO:0044129' and 'positive regulation of growth of symbiont in host ; GO:0044128'. synonym: "positive regulation of growth or development of symbiont within host" EXACT [] synonym: "positive regulation of invasive growth" BROAD [] synonym: "up regulation of growth or development of organism within host" EXACT [] synonym: "up-regulation of growth or development of organism within host" EXACT [] synonym: "upregulation of growth or development of organism within host" EXACT [] is_obsolete: true replaced_by: GO:0044128 replaced_by: GO:0044129 [Term] id: GO:0033667 name: negative regulation of growth or development of symbiont in host namespace: biological_process def: "OBSOLETE. Any process by which the symbiont stops, prevents or reduces its increase in size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont in host ; GO:0044131' and 'negative regulation of growth of symbiont in host ; GO:0044130'. synonym: "down regulation of growth or development of organism within host" EXACT [] synonym: "down-regulation of growth or development of organism within host" EXACT [] synonym: "downregulation of growth or development of organism within host" EXACT [] synonym: "inhibition of growth of development of organism within host" NARROW [] synonym: "negative regulation of growth or development of symbiont within host" EXACT [] synonym: "negative regulation of invasive growth" BROAD [] is_obsolete: true replaced_by: GO:0044130 replaced_by: GO:0044131 [Term] id: GO:0033668 name: negative regulation by symbiont of host apoptosis namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'. synonym: "down regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "down-regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "downregulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "inhibition by organism of host apoptotic programmed cell death" NARROW [] is_a: GO:0043066 ! negative regulation of apoptosis is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death is_a: GO:0052150 ! modulation by symbiont of host apoptosis [Term] id: GO:0033670 name: regulation of NAD+ kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] synonym: "NAD kinase regulator" NARROW [] synonym: "regulation of NAD kinase activity" EXACT [] is_a: GO:0043549 ! regulation of kinase activity [Term] id: GO:0033671 name: negative regulation of NAD+ kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] synonym: "down regulation of NAD+ kinase activity" EXACT [] synonym: "down-regulation of NAD+ kinase activity" EXACT [] synonym: "downregulation of NAD+ kinase activity" EXACT [] synonym: "inhibition of NAD+ kinase activity" NARROW [] synonym: "NAD+ kinase inhibitor" NARROW [] is_a: GO:0033670 ! regulation of NAD+ kinase activity is_a: GO:0033673 ! negative regulation of kinase activity [Term] id: GO:0033672 name: positive regulation of NAD+ kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] synonym: "NAD+ kinase activator" NARROW [] synonym: "stimulation of NAD+ kinase activity" NARROW [] synonym: "up regulation of NAD+ kinase activity" EXACT [] synonym: "up-regulation of NAD+ kinase activity" EXACT [] synonym: "upregulation of NAD+ kinase activity" EXACT [] is_a: GO:0033670 ! regulation of NAD+ kinase activity is_a: GO:0033674 ! positive regulation of kinase activity [Term] id: GO:0033673 name: negative regulation of kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] synonym: "down regulation of kinase activity" EXACT [] synonym: "down-regulation of kinase activity" EXACT [] synonym: "downregulation of kinase activity" EXACT [] synonym: "inhibition of kinase activity" NARROW [] synonym: "kinase inhibitor" NARROW [] is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051348 ! negative regulation of transferase activity [Term] id: GO:0033674 name: positive regulation of kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] synonym: "kinase activator" NARROW [] synonym: "stimulation of kinase activity" NARROW [] synonym: "up regulation of kinase activity" EXACT [] synonym: "up-regulation of kinase activity" EXACT [] synonym: "upregulation of kinase activity" EXACT [] is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051347 ! positive regulation of transferase activity [Term] id: GO:0033675 name: pericanalicular vesicle namespace: cellular_component def: "A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes." [PMID:15763347, PMID:9790571] is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0033676 name: double-stranded DNA-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of double-stranded DNA, and it drives another reaction." [GOC:mah] synonym: "dsDNA-dependent ATPase activity" EXACT [] is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0033677 name: DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA." [GOC:mah] subset: gosubset_prok xref: EC:2.7.7.- is_a: GO:0004386 ! helicase activity [Term] id: GO:0033678 name: 5'-3' DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah] synonym: "5' to 3' DNA/RNA helicase activity" EXACT [] is_a: GO:0033677 ! DNA/RNA helicase activity [Term] id: GO:0033679 name: 3'-5' DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah] synonym: "3' to 5' DNA/RNA helicase activity" EXACT [] is_a: GO:0033677 ! DNA/RNA helicase activity [Term] id: GO:0033680 name: ATP-dependent DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex." [GOC:mah] subset: gosubset_prok is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008094 ! DNA-dependent ATPase activity is_a: GO:0033677 ! DNA/RNA helicase activity [Term] id: GO:0033681 name: ATP-dependent 3'-5' DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah] synonym: "ATP-dependent 3' to 5' DNA/RNA helicase activity" EXACT [] is_a: GO:0033679 ! 3'-5' DNA/RNA helicase activity is_a: GO:0033680 ! ATP-dependent DNA/RNA helicase activity [Term] id: GO:0033682 name: ATP-dependent 5'-3' DNA/RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah] synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT [] is_a: GO:0033678 ! 5'-3' DNA/RNA helicase activity is_a: GO:0033680 ! ATP-dependent DNA/RNA helicase activity [Term] id: GO:0033683 name: nucleotide-excision repair, DNA incision namespace: biological_process def: "A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound." [GOC:elh, PMID:8631896] subset: gosubset_prok synonym: "DNA incision involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb] synonym: "nucleic acid cleavage involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0033684 name: regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] is_a: GO:0032276 ! regulation of gonadotropin secretion relationship: regulates GO:0032275 ! luteinizing hormone secretion [Term] id: GO:0033685 name: negative regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] synonym: "down regulation of luteinizing hormone secretion" EXACT [] synonym: "down-regulation of luteinizing hormone secretion" EXACT [] synonym: "downregulation of luteinizing hormone secretion" EXACT [] synonym: "inhibition of luteinizing hormone secretion" NARROW [] is_a: GO:0032277 ! negative regulation of gonadotropin secretion is_a: GO:0033684 ! regulation of luteinizing hormone secretion relationship: negatively_regulates GO:0032275 ! luteinizing hormone secretion [Term] id: GO:0033686 name: positive regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] synonym: "activation of luteinizing hormone secretion" NARROW [] synonym: "stimulation of luteinizing hormone secretion" NARROW [] synonym: "up regulation of luteinizing hormone secretion" EXACT [] synonym: "up-regulation of luteinizing hormone secretion" EXACT [] synonym: "upregulation of luteinizing hormone secretion" EXACT [] is_a: GO:0032278 ! positive regulation of gonadotropin secretion is_a: GO:0033684 ! regulation of luteinizing hormone secretion relationship: positively_regulates GO:0032275 ! luteinizing hormone secretion [Term] id: GO:0033687 name: osteoblast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:mah] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0033688 name: regulation of osteoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0033687 ! osteoblast proliferation [Term] id: GO:0033689 name: negative regulation of osteoblast proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation." [GOC:mah] synonym: "down regulation of osteoblast proliferation" EXACT [] synonym: "down-regulation of osteoblast proliferation" EXACT [] synonym: "downregulation of osteoblast proliferation" EXACT [] synonym: "inhibition of osteoblast proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0033688 ! regulation of osteoblast proliferation relationship: negatively_regulates GO:0033687 ! osteoblast proliferation [Term] id: GO:0033690 name: positive regulation of osteoblast proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of osteoblast proliferation." [GOC:mah] synonym: "activation of osteoblast proliferation" NARROW [] synonym: "stimulation of osteoblast proliferation" NARROW [] synonym: "up regulation of osteoblast proliferation" EXACT [] synonym: "up-regulation of osteoblast proliferation" EXACT [] synonym: "upregulation of osteoblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0033688 ! regulation of osteoblast proliferation relationship: positively_regulates GO:0033687 ! osteoblast proliferation [Term] id: GO:0033691 name: sialic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria." [CHEBI:26667, GOC:add, http://www.biology-online.org, ISBN:0721601465] synonym: "N-acetylneuraminic acid binding" NARROW [] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0033692 name: cellular polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, occurring at the level of an individual cell." [GOC:go_curators] subset: gosubset_prok synonym: "cellular glycan biosynthesis" EXACT [] synonym: "cellular glycan biosynthetic process" EXACT [] synonym: "cellular polysaccharide anabolism" EXACT [] synonym: "cellular polysaccharide biosynthesis" EXACT [] synonym: "cellular polysaccharide formation" EXACT [] synonym: "cellular polysaccharide synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0033693 name: neurofilament bundle assembly namespace: biological_process def: "The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules." [PMID:11034913, PMID:11264295] synonym: "NF bundle assembly" EXACT [] is_a: GO:0045110 ! intermediate filament bundle assembly is_a: GO:0060052 ! neurofilament cytoskeleton organization [Term] id: GO:0033694 name: oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] subset: gosubset_prok xref: EC:1.5.7 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0033695 name: oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule." [EC:1.17.5, GOC:mah] subset: gosubset_prok xref: EC:1.17.5 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0033696 name: negative regulation of extent of heterochromatin formation namespace: biological_process def: "Any process that reduces the extent of heterochromatin formation; reduces the size of a chromosomal region converted to heterochromatin." [GOC:mah] synonym: "maintenance of heterochromatin boundaries" RELATED [] synonym: "negative regulation of heterochromatin spreading" RELATED [] is_a: GO:0031452 ! negative regulation of heterochromatin formation is_a: GO:0031454 ! regulation of extent of heterochromatin formation [Term] id: GO:0033697 name: positive regulation of extent of heterochromatin formation namespace: biological_process def: "Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." [GOC:mah] synonym: "positive regulation of heterochromatin spreading" RELATED [] is_a: GO:0031453 ! positive regulation of heterochromatin formation is_a: GO:0031454 ! regulation of extent of heterochromatin formation [Term] id: GO:0033698 name: Rpd3L complex namespace: cellular_component alt_id: GO:0000508 def: "A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae)." [GOC:vw, PMID:17450151] synonym: "Clr6 histone deacetylase complex I/I'" EXACT [GOC:rb, GOC:vw] synonym: "Clr6L complex" EXACT [PMID:19040720] synonym: "Rpd3C(L)" EXACT [] is_a: GO:0070822 ! Sin3-type complex [Term] id: GO:0033699 name: DNA 5'-adenosine monophosphate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." [GOC:mah, PMID:16547001, PMID:17276982] synonym: "AMP-removal activity" RELATED [] synonym: "DNA 5'-adenylate hydrolase activity" EXACT [] synonym: "DNA adenylate hydrolysis activity" BROAD [] synonym: "DNA de-adenylation" RELATED [] synonym: "DNA deadenylation" RELATED [] is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity [Term] id: GO:0033700 name: phospholipid efflux namespace: biological_process def: "The directed movement of a phospholipid out of a cell or organelle." [GOC:mah] synonym: "phospholipid export" EXACT [] is_a: GO:0015914 ! phospholipid transport [Term] id: GO:0033701 name: dTDP-galactose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+." [EC:1.1.1.186] synonym: "dTDP-D-galactose:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.186] synonym: "dTDPgalactose 6-dehydrogenase activity" EXACT [EC:1.1.1.186] synonym: "thymidine-diphosphate-galactose dehydrogenase activity" EXACT [EC:1.1.1.186] xref: EC:1.1.1.186 xref: MetaCyc:DTDP-GALACTOSE-6-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033702 name: (+)-trans-carveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH." [EC:1.1.1.275, RHEA:14828] synonym: "(+)-trans-carveol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.275] xref: EC:1.1.1.275 xref: KEGG:R06117 xref: MetaCyc:RXN-9397 xref: RHEA:14828 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033703 name: 3beta-hydroxy-5beta-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH." [EC:1.1.1.277, RHEA:22947] synonym: "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.277] synonym: "3beta-hydroxysteroid 5beta-oxidoreductase activity" EXACT [EC:1.1.1.277] synonym: "3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity" EXACT [EC:1.1.1.277] xref: EC:1.1.1.277 xref: KEGG:R06166 xref: MetaCyc:1.1.1.277-RXN xref: RHEA:22947 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033704 name: 3beta-hydroxy-5alpha-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH." [EC:1.1.1.278, RHEA:18140] synonym: "3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.278] xref: EC:1.1.1.278 xref: KEGG:R07138 xref: MetaCyc:1.1.1.278-RXN xref: RHEA:18140 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033705 name: GDP-4-dehydro-6-deoxy-D-mannose reductase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+." [EC:1.1.1.281] comment: Note that this enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose). synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" BROAD [EC:1.1.1.281] synonym: "GDP-6-deoxy-D-lyxo-4-hexulose reductase activity" EXACT [EC:1.1.1.281] synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity" EXACT [EC:1.1.1.281] synonym: "Rmd" RELATED [EC:1.1.1.281] xref: EC:1.1.1.281 xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033706 name: quinate/shikimate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+, and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+." [EC:1.1.1.282] synonym: "L-quinate:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.1.1.282] synonym: "YdiB" RELATED [EC:1.1.1.282] xref: EC:1.1.1.282 xref: MetaCyc:RXN-7967 xref: MetaCyc:RXN-7968 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033707 name: 3''-deamino-3''-oxonicotianamine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+." [EC:1.1.1.285] synonym: "2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity" EXACT [EC:1.1.1.285] xref: EC:1.1.1.285 xref: MetaCyc:1.1.1.285-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033708 name: isocitrate-homoisocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+." [EC:1.1.1.286] synonym: "homoisocitrate-isocitrate dehydrogenase activity" EXACT [EC:1.1.1.286] synonym: "isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.286] synonym: "PH1722" RELATED [EC:1.1.1.286] xref: EC:1.1.1.286 xref: MetaCyc:RXN-7969 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033709 name: D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity namespace: molecular_function def: "Catalysis of the reactions: D-arabinitol + NADP+ = D-ribulose + NADPH + H+." [EC:1.1.1.287] synonym: "ARD1p" RELATED [EC:1.1.1.287] synonym: "D-arabinitol dehydrogenase 1 activity" BROAD [EC:1.1.1.287] synonym: "D-arabinitol:NADP+ dehydrogenase activity" BROAD [EC:1.1.1.287] synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" BROAD [EC:1.1.1.287] xref: EC:1.1.1.- xref: KEGG:R07144 xref: MetaCyc:RXN-7972 xref: RHEA:11871 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033711 name: 4-phosphoerythronate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH." [EC:1.1.1.290, RHEA:18832] synonym: "4-O-phosphoerythronate dehydrogenase activity" EXACT [EC:1.1.1.290] synonym: "4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.290] synonym: "4PE dehydrogenase activity" EXACT [EC:1.1.1.290] synonym: "erythronate-4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.290] synonym: "PdxB" RELATED [EC:1.1.1.290] synonym: "PdxB 4PE dehydrogenase activity" EXACT [EC:1.1.1.290] xref: EC:1.1.1.290 xref: KEGG:R04210 xref: MetaCyc:ERYTHRON4PDEHYDROG-RXN xref: RHEA:18832 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033712 name: 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH." [EC:1.1.1.292, RHEA:24211] synonym: "1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.292] synonym: "AFR" RELATED [EC:1.1.1.292] xref: EC:1.1.1.292 xref: KEGG:R08194 xref: MetaCyc:1.1.1.292-RXN xref: RHEA:24211 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033713 name: choline:oxygen 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide." [EC:1.1.3.17] synonym: "choline oxidase activity" BROAD [EC:1.1.3.17] xref: EC:1.1.3.17 xref: MetaCyc:CHOLINE-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0033714 name: secondary-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + secondary alcohol = H(2)O(2) + ketone." [EC:1.1.3.18, RHEA:23183] synonym: "polyvinyl alcohol oxidase activity" EXACT [EC:1.1.3.18] synonym: "secondary alcohol oxidase activity" EXACT [EC:1.1.3.18] synonym: "secondary-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.18] xref: EC:1.1.3.18 xref: KEGG:R02277 xref: MetaCyc:SECONDARY-ALCOHOL-OXIDASE-RXN xref: RHEA:23183 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0033715 name: nucleoside oxidase activity namespace: molecular_function def: "Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O." [EC:1.1.3.28] synonym: "nucleoside:oxygen 5'-oxidoreductase activity" EXACT [EC:1.1.3.28] xref: EC:1.1.3.28 xref: MetaCyc:NUCLEOSIDE-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0033716 name: nucleoside oxidase (hydrogen peroxide-forming) activity namespace: molecular_function def: "Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide; (1a) adenosine + O2 = 5'-dehydroadenosine + hydrogen peroxide, and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + hydrogen peroxide." [EC:1.1.3.39] synonym: "nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity" EXACT [EC:1.1.3.39] xref: EC:1.1.3.39 xref: MetaCyc:1.1.3.39-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0033717 name: gluconate 2-dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor." [EC:1.1.99.3] synonym: "2-ketogluconate reductase activity" BROAD [EC:1.1.99.3] synonym: "D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.3] synonym: "D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity" EXACT [EC:1.1.99.3] synonym: "D-gluconate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.3] synonym: "D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.3] synonym: "gluconate oxidase activity" EXACT [EC:1.1.99.3] synonym: "gluconic acid dehydrogenase activity" EXACT [EC:1.1.99.3] synonym: "gluconic dehydrogenase activity" EXACT [EC:1.1.99.3] xref: EC:1.1.99.3 xref: MetaCyc:GLUCONATE-2-DEHYDROGENASE-RXN is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0033718 name: pyranose dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor." [EC:1.1.99.29] synonym: "PDH" RELATED [EC:1.1.99.29] synonym: "pyranose dehydrogenase activity" EXACT [EC:1.1.99.29] synonym: "pyranose-quinone oxidoreductase activity" EXACT [EC:1.1.99.29] synonym: "pyranose:acceptor oxidoreductase activity" EXACT [EC:1.1.99.29] synonym: "quinone-dependent pyranose dehydrogenase activity" EXACT [EC:1.1.99.29] xref: EC:1.1.99.29 xref: MetaCyc:RXN-7961 xref: MetaCyc:RXN-7962 xref: MetaCyc:RXN-7963 xref: MetaCyc:RXN-7965 xref: MetaCyc:RXN-7966 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0033719 name: 2-oxo-acid reductase activity namespace: molecular_function def: "Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor." [EC:1.1.99.30] synonym: "(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.30] synonym: "(2R)-hydroxycarboxylate-viologen-oxidoreductase activity" EXACT [EC:1.1.99.30] synonym: "2-oxoacid reductase activity" EXACT [EC:1.1.99.30] synonym: "HVOR" RELATED [EC:1.1.99.30] xref: EC:1.1.99.30 xref: MetaCyc:1.1.99.30-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0033720 name: (S)-mandelate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor." [EC:1.1.99.31] synonym: "(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.31] synonym: "L(+)-mandelate dehydrogenase activity" EXACT [EC:1.1.99.31] synonym: "MDH" RELATED [EC:1.1.99.31] xref: EC:1.1.99.31 xref: MetaCyc:MANDELATE-DEHYDROGENASE-RXN xref: MetaCyc:MANDELATE-OXY-RXN xref: UM-BBD_reactionID:r1048 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0033721 name: aldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+." [EC:1.2.1.4] synonym: "aldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.4] synonym: "NADP-acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.4] synonym: "NADP-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.4] xref: EC:1.2.1.4 xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0033722 name: malonate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+." [EC:1.2.1.15] synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.15] synonym: "malonic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.15] xref: EC:1.2.1.15 xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0033723 name: fluoroacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+." [EC:1.2.1.69] synonym: "fluoroacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.69] xref: EC:1.2.1.69 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0033726 name: aldehyde ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.5] synonym: "aldehyde:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5] synonym: "AOR" RELATED [EC:1.2.7.5] synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5] xref: EC:1.2.7.5 xref: MetaCyc:1.2.7.5-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0033727 name: aldehyde dehydrogenase (FAD-independent) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor." [EC:1.2.99.7] synonym: "aldehyde oxidoreductase activity" EXACT [EC:1.2.99.7] synonym: "aldehyde:acceptor oxidoreductase (FAD-independent) activity" EXACT [EC:1.2.99.7] synonym: "AORDd" RELATED [EC:1.2.99.7] synonym: "Mop" RELATED [EC:1.2.99.7] xref: EC:1.2.99.7 xref: MetaCyc:1.2.99.3-RXN xref: MetaCyc:1.2.99.7-RXN xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0033728 name: divinyl chlorophyllide a 8-vinyl-reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+." [EC:1.3.1.75] synonym: "4VCR" RELATED [EC:1.3.1.75] synonym: "[4-vinyl]chlorophyllide a reductase activity" EXACT [EC:1.3.1.75] synonym: "chlorophyllide-a:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.75] xref: EC:1.3.1.75 xref: MetaCyc:RXN-5286 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0033729 name: anthocyanidin reductase activity namespace: molecular_function def: "Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+." [EC:1.3.1.77] synonym: "ANR" RELATED [EC:1.3.1.77] synonym: "AtANR" RELATED [EC:1.3.1.77] synonym: "flavan-3-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.77] synonym: "MtANR" RELATED [EC:1.3.1.77] xref: EC:1.3.1.77 xref: MetaCyc:1.3.1.77-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0033730 name: arogenate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2." [EC:1.3.1.78] synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.78] synonym: "L-arogenate:NADP+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.78] synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.78] synonym: "TyrAa" RELATED [EC:1.3.1.78] synonym: "TyrAAT1" RELATED [EC:1.3.1.78] synonym: "TyrAAT2" RELATED [EC:1.3.1.78] xref: EC:1.3.1.78 xref: MetaCyc:1.3.1.78-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0033731 name: arogenate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2." [EC:1.3.1.79] synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.79] synonym: "L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.79] synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.79] xref: EC:1.3.1.79 xref: MetaCyc:1.3.1.79-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0033732 name: pyrroloquinoline-quinone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 2 H(2)O + 2 H(2)O(2) + H(+) + pyrroloquinoline quinone." [EC:1.3.3.11, RHEA:10695] synonym: "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.3.3.11] synonym: "PqqC" RELATED [EC:1.3.3.11] xref: EC:1.3.3.11 xref: KEGG:R07353 xref: MetaCyc:1.3.3.11-RXN xref: RHEA:10695 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0033734 name: (R)-benzylsuccinyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein." [EC:1.3.99.21] synonym: "(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.21] synonym: "(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.21] synonym: "BbsG" RELATED [EC:1.3.99.21] xref: EC:1.3.99.21 xref: UM-BBD_reactionID:r0330 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0033735 name: aspartate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+." [EC:1.4.1.21] synonym: "L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.21] synonym: "NAD-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] synonym: "NADH2-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] synonym: "NADP+-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] xref: EC:1.4.1.21 xref: MetaCyc:1.4.1.21-RXN is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0033736 name: L-lysine 6-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + H(2)O + O(2) = allysine + H(2)O(2) + NH(4)(+)." [EC:1.4.3.20, RHEA:22551] synonym: "L-lysine-epsilon-oxidase activity" EXACT [EC:1.4.3.20] synonym: "L-lysine:oxygen 6-oxidoreductase (deaminating) activity" EXACT [EC:1.4.3.20] synonym: "Lod" RELATED [EC:1.4.3.20] synonym: "LodA" RELATED [EC:1.4.3.20] synonym: "marinocine" RELATED [EC:1.4.3.20] xref: EC:1.4.3.20 xref: KEGG:R07598 xref: MetaCyc:1.4.3.20-RXN xref: RHEA:22551 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0033737 name: 1-pyrroline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.5.1.35] synonym: "1-pyrroline:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.35] synonym: "ABALDH" RELATED [EC:1.5.1.35] synonym: "gamma-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.5.1.35] synonym: "YdcW" RELATED [EC:1.5.1.35] xref: EC:1.5.1.35 xref: MetaCyc:1.5.1.35-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0033738 name: methylenetetrahydrofolate reductase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin." [EC:1.5.7.1] synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1] synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" EXACT [EC:1.5.7.1] xref: EC:1.5.7.1 xref: MetaCyc:RXN-5061 is_a: GO:0033694 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0033739 name: preQ1 synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH." [EC:1.7.1.13, RHEA:13412] synonym: "7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity" EXACT systematic_synonym [EC:1.7.1.13] synonym: "7-cyano-7-deazaguanine reductase activity" EXACT [EC:1.7.1.13] synonym: "preQ0 oxidoreductase activity" EXACT [EC:1.7.1.13] synonym: "preQ0 reductase activity" EXACT [EC:1.7.1.13] synonym: "QueF" RELATED [EC:1.7.1.13] synonym: "queuine synthase activity" RELATED [] synonym: "queuine:NADP+ oxidoreductase activity" RELATED [] synonym: "YkvM" RELATED [EC:1.7.1.13] xref: EC:1.7.1.13 xref: KEGG:R07605 xref: MetaCyc:RXN0-4022 xref: RHEA:13412 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0033740 name: hydroxylamine oxidoreductase activity namespace: molecular_function def: "Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor." [EC:1.7.99.8] synonym: "hydroxylamine:acceptor oxidoreductase activity" EXACT [EC:1.7.99.8] xref: EC:1.7.99.8 xref: MetaCyc:1.7.99.8-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0033741 name: adenylyl-sulfate reductase (glutathione) activity namespace: molecular_function def: "Catalysis of the reaction: AMP + glutathione disulfide + H(+) + sulfite = 5'-adenylyl sulfate + 2 glutathione." [EC:1.8.4.9, RHEA:14144] synonym: "5'-adenylylsulfate reductase activity" EXACT [EC:1.8.4.9] synonym: "AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9] synonym: "AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9] synonym: "plant-type 5'-adenylylsulfate reductase activity" NARROW [EC:1.8.4.9] xref: EC:1.8.4.9 xref: KEGG:R05717 xref: MetaCyc:1.8.4.9-RXN xref: RHEA:14144 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0033743 name: peptide-methionine (R)-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine residue + H(2)O + thioredoxin disulfide = L-methionine (R)-S-oxide residue + thioredoxin." [EC:1.8.4.12, RHEA:24167] synonym: "methionine S-oxide reductase (R-form oxidizing) activity" EXACT [EC:1.8.4.12] synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.12] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.12] synonym: "methionine sulfoxide reductase B activity" NARROW [EC:1.8.4.12] synonym: "MsrB" RELATED [EC:1.8.4.12] synonym: "peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.12] synonym: "PilB" RELATED [EC:1.8.4.12] synonym: "pMRsr" RELATED [EC:1.8.4.12] synonym: "pMSR" RELATED [EC:1.8.4.12] synonym: "selenoprotein R" RELATED [EC:1.8.4.12] synonym: "SelR" RELATED [EC:1.8.4.12] synonym: "SelX" RELATED [EC:1.8.4.12] xref: EC:1.8.4.12 xref: KEGG:R07607 xref: MetaCyc:1.8.4.12-RXN xref: RHEA:24167 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0033744 name: L-methionine-(S)-S-oxide reductase activity namespace: molecular_function alt_id: GO:0000317 def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.13] synonym: "acetylmethionine sulfoxide reductase activity" EXACT [EC:1.8.4.13] synonym: "free-methionine (S)-S-oxide reductase activity" EXACT [EC:1.8.4.13] synonym: "fSMsr" RELATED [EC:1.8.4.13] synonym: "L-methionine:oxidized-thioredoxin S-oxidoreductase activity" EXACT [EC:1.8.4.13] synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.13] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.13] synonym: "methionine-S-oxide reductase activity" EXACT [PMID:11169920] synonym: "methyl sulfoxide reductase I and II activity" EXACT [EC:1.8.4.13] xref: EC:1.8.4.13 xref: MetaCyc:1.8.4.13-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0033745 name: L-methionine-(R)-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.14] synonym: "free met-R-(o) reductase activity" EXACT [EC:1.8.4.14] synonym: "free-methionine (R)-S-oxide reductase activity" EXACT [EC:1.8.4.14] synonym: "fRMsr" RELATED [EC:1.8.4.14] synonym: "FRMsr" RELATED [EC:1.8.4.14] synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.14] xref: EC:1.8.4.14 xref: MetaCyc:1.8.4.14-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0033746 name: histone demethylase activity (H3-R2 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein." [GOC:mah] is_a: GO:0032452 ! histone demethylase activity [Term] id: GO:0033747 name: versatile peroxidase activity namespace: molecular_function def: "Catalysis of the reactions: Reactive Black 5 + hydrogen peroxide = oxidized Reactive Black 5 + 2 H2O, and donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.16] synonym: "hybrid peroxidase activity" EXACT [EC:1.11.1.16] synonym: "polyvalent peroxidase activity" EXACT [EC:1.11.1.16] synonym: "reactive-black-5:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.16] synonym: "VP" RELATED [EC:1.11.1.16] xref: EC:1.11.1.16 xref: MetaCyc:RXN-8666 xref: MetaCyc:RXN-8667 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0033748 name: hydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: H2 + A = AH2." [EC:1.12.99.6] synonym: "H2 producing hydrogenase activity" BROAD [EC:1.12.99.6] synonym: "hydrogen-lyase activity" BROAD [EC:1.12.99.6] synonym: "hydrogen:(acceptor) oxidoreductase activity" EXACT [EC:1.12.99.6] synonym: "hydrogen:acceptor oxidoreductase activity" EXACT [EC:1.12.99.6] synonym: "hydrogenlyase activity" BROAD [EC:1.12.99.6] synonym: "uptake hydrogenase activity" BROAD [EC:1.12.99.6] xref: EC:1.12.99.6 xref: MetaCyc:RXN0-4141 xref: MetaCyc:RXN0-5256 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0033749 name: histone demethylase activity (H4-R3 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein." [GOC:mah] is_a: GO:0032452 ! histone demethylase activity [Term] id: GO:0033750 name: ribosome localization namespace: biological_process def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "ribosome localisation" EXACT [] is_a: GO:0051640 ! organelle localization [Term] id: GO:0033751 name: linoleate diol synthase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate." [EC:1.13.11.44] synonym: "linoleate (8R)-dioxygenase activity" EXACT [EC:1.13.11.44] synonym: "linoleate 8-dioxygenase activity" EXACT [EC:1.13.11.44] synonym: "linoleate:oxygen 7S,8S-oxidoreductase activity" EXACT [EC:1.13.11.44] xref: EC:1.13.11.44 xref: MetaCyc:1.13.11.44-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0033752 name: acetylacetone-cleaving enzyme activity namespace: molecular_function def: "Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal." [EC:1.13.11.50] synonym: "acetylacetone dioxygenase activity" EXACT [EC:1.13.11.50] synonym: "acetylacetone-cleaving enzyme" RELATED [EC:1.13.11.50] synonym: "acetylacetone:oxygen oxidoreductase activity" EXACT [EC:1.13.11.50] synonym: "diketone cleaving dioxygenase activity" EXACT [EC:1.13.11.50] synonym: "diketone cleaving enzyme" RELATED [EC:1.13.11.50] synonym: "Dke1" RELATED [EC:1.13.11.50] xref: EC:1.13.11.50 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0033753 name: establishment of ribosome localization namespace: biological_process def: "The directed movement of the ribosome to a specific location." [GOC:mah] synonym: "establishment of ribosome localisation" EXACT [] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0033750 ! ribosome localization [Term] id: GO:0033754 name: indoleamine 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reactions: tryptophan + O2 = N-formylkynurenine; D-tryptophan + O2 = N-formyl-D-kynurenine; and L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.52] synonym: "D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity" NARROW [EC:1.13.11.52] synonym: "IDO" RELATED [EC:1.13.11.52] synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52] xref: EC:1.13.11.52 xref: MetaCyc:RXN-8664 xref: MetaCyc:RXN-8665 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0033755 name: sulfur oxygenase/reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+." [EC:1.13.11.55] synonym: "SOR" RELATED [EC:1.13.11.55] synonym: "sulfur oxygenase activity" BROAD [EC:1.13.11.55] synonym: "sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity" EXACT [EC:1.13.11.55] synonym: "sulphur oxygenase/reductase activity" EXACT [] xref: EC:1.13.11.55 xref: MetaCyc:1.13.11.55-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0033756 name: Oplophorus-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu." [EC:1.13.12.13] synonym: "Oplophorus luciferase activity" EXACT [EC:1.13.12.13] synonym: "Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity" EXACT [EC:1.13.12.13] xref: EC:1.13.12.13 xref: MetaCyc:RXN-3361 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0033757 name: glucoside 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor." [EC:1.1.99.13] synonym: "D-aldohexopyranoside dehydrogenase" EXACT [EC:1.1.99.13] synonym: "D-aldohexoside:(acceptor) 3-oxidoreductase" EXACT [EC:1.1.99.13] synonym: "D-aldohexoside:acceptor 3-oxidoreductase" EXACT [EC:1.1.99.13] synonym: "D-aldohexoside:cytochrome c oxidoreductase" EXACT [EC:1.1.99.13] synonym: "hexopyranoside-cytochrome c oxidoreductase" EXACT [EC:1.1.99.13] xref: EC:1.1.99.13 xref: MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN xref: Wikipedia:Glucoside_3-dehydrogenase is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0033758 name: clavaminate synthase activity namespace: molecular_function def: "Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O." [EC:1.14.11.21] synonym: "clavaminate synthase 2 activity" NARROW [EC:1.14.11.21] synonym: "clavaminic acid synthase activity" EXACT [EC:1.14.11.21] synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.21] xref: EC:1.14.11.21 xref: MetaCyc:1.14.11.21-RXN is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0033759 name: flavone synthase activity namespace: molecular_function def: "Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O." [EC:1.14.11.22] synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity" EXACT [EC:1.14.11.22] synonym: "flavone synthase I activity" EXACT [EC:1.14.11.22] synonym: "FNS I" RELATED [EC:1.14.11.22] xref: EC:1.14.11.22 xref: MetaCyc:RXN-8000 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0033760 name: 2'-deoxymugineic-acid 2'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O(2) = CO(2) + H(+) + mugineate + succinate." [EC:1.14.11.24, RHEA:12203] synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity" EXACT [EC:1.14.11.24] synonym: "IDS3" RELATED [EC:1.14.11.24] xref: EC:1.14.11.24 xref: KEGG:R07185 xref: MetaCyc:1.14.11.24-RXN xref: RHEA:12203 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0033761 name: mugineic-acid 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2, and 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2." [EC:1.14.11.25] synonym: "IDS2" RELATED [EC:1.14.11.25] synonym: "mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.25] xref: EC:1.14.11.25 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0033762 name: response to glucagon stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl] is_a: GO:0043434 ! response to peptide hormone stimulus [Term] id: GO:0033763 name: proline 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.28] synonym: "L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.28] synonym: "P-3-H" RELATED [EC:1.14.11.28] xref: EC:1.14.11.28 xref: MetaCyc:1.14.11.28-RXN is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0033764 name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative." [GOC:mah] subset: gosubset_prok xref: EC:1.1.1.- is_a: GO:0016229 ! steroid dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033765 name: steroid dehydrogenase activity, acting on the CH-CH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative." [GOC:mah] subset: gosubset_prok xref: EC:1.1.1.- is_a: GO:0016229 ! steroid dehydrogenase activity is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0033766 name: 2-hydroxyquinoline 8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-2-ol = H(2)O + NAD(+) + quinoline-2,8-diol." [EC:1.14.13.61, RHEA:22083] synonym: "2-oxo-1,2-dihydroquinoline 8-monooxygenase activity" EXACT [EC:1.14.13.61] synonym: "quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity" EXACT [EC:1.14.13.61] xref: EC:1.14.13.61 xref: KEGG:R05158 xref: MetaCyc:1.14.13.61-RXN xref: RHEA:22083 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033767 name: 4-hydroxyacetophenone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4'-hydroxyacetophenone + H(+) + NADPH + O(2) = 4-hydroxyphenyl acetate + H(2)O + NADP(+)." [EC:1.14.13.84, RHEA:22919] synonym: "(+)-limonene 6-monooxygenase activity" EXACT [EC:1.14.13.80] synonym: "(+)-limonene-6-hydroxylase activity" EXACT [EC:1.14.13.80] synonym: "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity" EXACT [EC:1.14.13.84] synonym: "(R)-limonene 6-monooxygenase activity" EXACT [EC:1.14.13.80] synonym: "(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.80] synonym: "HAPMO" RELATED [EC:1.14.13.84] xref: EC:1.14.13.80 xref: EC:1.14.13.84 xref: KEGG:R06119 xref: KEGG:R06892 xref: MetaCyc:1.14.13.84-RXN xref: MetaCyc:RXN-10746 xref: RHEA:18960 xref: RHEA:22919 xref: UM-BBD_reactionID:r0756 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033768 name: SUMO-targeted ubiquitin ligase complex namespace: cellular_component def: "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865] is_a: GO:0000152 ! nuclear ubiquitin ligase complex [Term] id: GO:0033769 name: glyceollin synthase activity namespace: molecular_function def: "Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O." [EC:1.14.13.85] synonym: "2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.14.13.85] synonym: "dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity" EXACT [EC:1.14.13.85] xref: EC:1.14.13.85 xref: MetaCyc:2.5.1.36-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033770 name: 2-hydroxyisoflavanone synthase activity namespace: molecular_function def: "Catalysis of the reaction: apigenin + 2 NADPH + 2 H+ + O2 = 2-hydroxy-2,3-dihydrogenistein + 2 NADP+ + H2O." [EC:1.14.13.86] synonym: "2-HIS" RELATED [EC:1.14.13.86] synonym: "apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming) activity" EXACT [EC:1.14.13.86] xref: EC:1.14.13.86 xref: MetaCyc:RXN-7750 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033771 name: licodione synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + liquiritigenin + NADPH + O(2) = H(2)O + licodione + NADP(+)." [EC:1.14.13.87, RHEA:15700] synonym: "(2S)-flavanone 2-hydroxylase activity" EXACT [EC:1.14.13.87] synonym: "liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity" EXACT [EC:1.14.13.87] xref: EC:1.14.13.87 xref: KEGG:R07198 xref: MetaCyc:1.14.13.87-RXN xref: RHEA:15700 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033772 name: flavonoid 3',5'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O." [EC:1.14.13.88] synonym: "F3',5'H" RELATED [EC:1.14.13.88] synonym: "F3'5'H" RELATED [EC:1.14.13.88] synonym: "flavanone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.88] xref: EC:1.14.13.88 xref: MetaCyc:RXN-7783 xref: MetaCyc:RXN-8671 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033773 name: isoflavone 2'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: an isoflavone + NADPH + H+ + O2 = a 2'-hydroxyisoflavone + NADP+ + H2O." [EC:1.14.13.89] synonym: "CYP Ge-3" RELATED [EC:1.14.13.89] synonym: "CYP81E1" RELATED [EC:1.14.13.89] synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.89] synonym: "isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating) activity" EXACT [EC:1.14.13.89] xref: EC:1.14.13.89 xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033774 name: basal labyrinth namespace: cellular_component def: "A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane." [GOC:mah, GOC:sart, PMID:11640882] is_a: GO:0044464 ! cell part relationship: part_of GO:0045178 ! basal part of cell [Term] id: GO:0033775 name: deoxysarpagine hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deoxysarpagine + H(+) + NADPH + O(2) = H(2)O + NADP(+) + sarpagine." [EC:1.14.13.91, RHEA:14240] synonym: "10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity" EXACT [EC:1.14.13.91] synonym: "DOSH" RELATED [EC:1.14.13.91] xref: EC:1.14.13.91 xref: KEGG:R05828 xref: MetaCyc:1.14.13.91-RXN xref: RHEA:14240 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033776 name: phenylacetone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + phenylacetone = benzyl acetate + H(2)O + NADP(+)." [EC:1.14.13.92, RHEA:10127] synonym: "PAMO" RELATED [EC:1.14.13.92] synonym: "phenylacetone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.92] xref: EC:1.14.13.92 xref: KEGG:R07201 xref: MetaCyc:1.14.13.92-RXN xref: RHEA:10127 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033777 name: lithocholate 6beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860] synonym: "6beta-hydroxylase activity" BROAD [EC:1.14.13.94] synonym: "CYP3A10" RELATED [EC:1.14.13.94] synonym: "cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity" EXACT [EC:1.14.13.94] synonym: "lithocholate 6beta-monooxygenase activity" EXACT [EC:1.14.13.94] synonym: "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity" EXACT [EC:1.14.13.94] xref: EC:1.14.13.94 xref: KEGG:R07203 xref: MetaCyc:1.14.13.94-RXN xref: RHEA:18860 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033778 name: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+)." [EC:1.14.13.95, RHEA:10507] synonym: "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity" EXACT [EC:1.14.13.95] synonym: "7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.95] synonym: "CYP12" RELATED [EC:1.14.13.95] synonym: "HCO 12alpha-hydroxylase activity" EXACT [EC:1.14.13.95] synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.95] xref: EC:1.14.13.95 xref: KEGG:R04826 xref: MetaCyc:1.14.13.95-RXN xref: Reactome:262350 "7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity" xref: RHEA:10507 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033779 name: 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H(+) + NADPH + O(2) = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(2)O + NADP(+)." [EC:1.14.13.96, RHEA:15264] synonym: "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity" EXACT [EC:1.14.13.96] synonym: "5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.96] synonym: "CYP8B1" RELATED [EC:1.14.13.96] synonym: "cytochrome P450 8B1" RELATED [EC:1.14.13.96] synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.96] xref: EC:1.14.13.96 xref: KEGG:R07204 xref: MetaCyc:1.14.13.96-RXN xref: RHEA:15264 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033780 name: taurochenodeoxycholate 6alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97] synonym: "CYP3A4" RELATED [EC:1.14.13.97] synonym: "CYP4A21" RELATED [EC:1.14.13.97] synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" EXACT [EC:1.14.13.97] synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" EXACT [EC:1.14.13.97] xref: EC:1.14.13.97 xref: MetaCyc:RXN-7977 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033781 name: cholesterol 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+)." [EC:1.14.13.98, RHEA:22719] synonym: "cholesterol 24-monooxygenase activity" EXACT [EC:1.14.13.98] synonym: "cholesterol 24S-hydroxylase activity" EXACT [EC:1.14.13.98] synonym: "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity" EXACT [EC:1.14.13.98] synonym: "CYP46" RELATED [EC:1.14.13.98] synonym: "CYP46A1" RELATED [EC:1.14.13.98] synonym: "cytochrome P450 46A1" RELATED [EC:1.14.13.98] xref: EC:1.14.13.98 xref: KEGG:R07207 xref: MetaCyc:1.14.13.98-RXN xref: Reactome:262395 "cholesterol 24-hydroxylase activity" xref: RHEA:22719 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033782 name: 24-hydroxycholesterol 7alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (24R)-cholest-5-ene-3beta,24-diol + H(+) + NADPH + O(2) = (24R)-7alpha,24-dihydroxycholesterol + H(2)O + NADP(+)." [EC:1.14.13.99, RHEA:16096] synonym: "(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.99] synonym: "24-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.99] synonym: "CYP39A1" RELATED [EC:1.14.13.99] synonym: "CYP39A1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.99] xref: EC:1.14.13.99 xref: KEGG:R07208 xref: MetaCyc:1.14.13.99-RXN xref: RHEA:16096 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033783 name: 25-hydroxycholesterol 7alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O." [EC:1.14.13.100] synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.100] synonym: "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.100] synonym: "CYP7B1" RELATED [EC:1.14.13.100] synonym: "CYP7B1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.100] xref: EC:1.14.13.100 xref: MetaCyc:RXN-7980 xref: MetaCyc:RXN-7981 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033784 name: senecionine N-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + senecionine = H(2)O + NADP(+) + senecionine N-oxide." [EC:1.14.13.101, RHEA:11423] synonym: "senecionine monooxygenase (N-oxide-forming) activity" EXACT [EC:1.14.13.101] synonym: "senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity" EXACT [EC:1.14.13.101] synonym: "SNO" RELATED [EC:1.14.13.101] xref: EC:1.14.13.101 xref: KEGG:R07373 xref: MetaCyc:1.14.13.101-RXN xref: RHEA:11423 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033785 name: heptose 7-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP." [MetaCyc:RXN0-4341] subset: gosubset_prok synonym: "D-alpha,beta-D-heptose 7-phosphate 1-kinase activity" EXACT [] xref: EC:2.7.1.- xref: IMG:02784 xref: MetaCyc:RXN0-4341 is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0033786 name: heptose 1-phosphate adenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose." [MetaCyc:RXN0-4342] subset: gosubset_prok synonym: "D-beta-D-heptose 1-phosphate adenylyltransferase activity" EXACT [] xref: IMG:02786 xref: MetaCyc:RXN0-4342 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0033787 name: cyanocobalamin reductase (cyanide-eliminating) activity namespace: molecular_function def: "Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP(+) = cyanocob(III)alamin + H(+) + NADPH." [EC:1.16.1.6, RHEA:16116] synonym: "cob(I)alamin, cyanide:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.6] synonym: "cyanocobalamin reductase (NADPH, cyanide-eliminating) activity" EXACT [EC:1.16.1.6] synonym: "cyanocobalamin reductase (NADPH; CN-eliminating) activity" EXACT [EC:1.16.1.6] synonym: "cyanocobalamin reductase activity" EXACT [EC:1.16.1.6] synonym: "NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6] synonym: "NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6] xref: EC:1.16.1.6 xref: KEGG:R02999 xref: MetaCyc:1.6.99.12-RXN xref: RHEA:16116 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0033788 name: leucoanthocyanidin reductase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+." [EC:1.17.1.3] synonym: "(2R,3S)-catechin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.17.1.3] synonym: "leucocyanidin reductase activity" EXACT [EC:1.17.1.3] xref: EC:1.17.1.3 xref: MetaCyc:RXN-1484 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0033789 name: phenylacetyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 1,4-benzoquinone + H(2)O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA." [EC:1.17.5.1, RHEA:15708] synonym: "phenylacetyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.17.5.1] synonym: "phenylacetyl-CoA:quinone oxidoreductase activity" EXACT [EC:1.17.5.1] xref: EC:1.17.5.1 xref: KEGG:R07222 xref: MetaCyc:1.17.5.1-RXN xref: RHEA:15708 is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [Term] id: GO:0033790 name: hydroxymethylfurfural reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033791 name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor." [EC:1.17.99.3] synonym: "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity" EXACT [EC:1.17.99.3] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity" EXACT [EC:1.17.99.3] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3] synonym: "THC-CoA oxidase activity" EXACT [EC:1.17.99.3] synonym: "THCA-CoA oxidase activity" EXACT [EC:1.17.99.3] synonym: "trihydroxycoprostanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3] xref: EC:1.17.99.3 xref: MetaCyc:1.17.99.3-RXN is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0033792 name: bile-acid 7alpha-dehydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: deoxycholate + FAD + H2O = cholate + FADH2, and lithocholate + FAD + H2O = chenodeoxycholate + FADH2." [EC:1.17.99.5] synonym: "7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5] synonym: "bile acid 7-dehydroxylase activity" EXACT [EC:1.17.99.5] synonym: "cholate 7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5] synonym: "deoxycholate:FAD oxidoreductase (7alpha-dehydroxylating) activity" EXACT [EC:1.17.99.5] synonym: "deoxycholate:NAD+ oxidoreductase activity" EXACT [EC:1.17.99.5] xref: EC:1.17.99.5 xref: MetaCyc:RXN-8658 xref: MetaCyc:RXN-8659 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0033793 name: aureusidin synthase activity namespace: molecular_function def: "Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O." [EC:1.21.3.6] synonym: "2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity" EXACT [EC:1.21.3.6] xref: EC:1.21.3.6 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0033794 name: sarcosine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin." [EC:1.21.4.3] synonym: "acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity" EXACT [EC:1.21.4.3] xref: EC:1.21.4.3 is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: GO:0033795 name: betaine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin." [EC:1.21.4.4] synonym: "acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity" EXACT [EC:1.21.4.4] xref: EC:1.21.4.4 is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: GO:0033796 name: sulfur reductase activity namespace: molecular_function def: "Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide." [EC:1.97.1.3] synonym: "(donor):sulfur oxidoreductase activity" EXACT [EC:1.97.1.3] synonym: "sulphur reductase activity" EXACT [] xref: EC:1.97.1.3 xref: MetaCyc:1.97.1.3-RXN xref: MetaCyc:RXN-8269 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0033797 name: selenate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 e(-) + 2 H(+) + selenate = H(2)O + selenite." [EC:1.97.1.9, RHEA:14031] synonym: "selenite:reduced acceptor oxidoreductase activity" EXACT [EC:1.97.1.9] xref: EC:1.97.1.9 xref: KEGG:R07229 xref: MetaCyc:RXN0-2101 xref: RHEA:14031 xref: UM-BBD_reactionID:r0828 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0033798 name: thyroxine 5-deiodinase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2." [EC:1.97.1.11] synonym: "acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity" EXACT [EC:1.97.1.11] synonym: "diiodothyronine 5'-deiodinase activity" BROAD [EC:1.97.1.11] synonym: "inner ring-deiodinating pathway" EXACT [PMID:20403357] synonym: "iodothyronine 5-deiodinase activity" EXACT [EC:1.97.1.11] synonym: "iodothyronine inner ring monodeiodinase activity" EXACT [EC:1.97.1.11] synonym: "type III iodothyronine deiodinase activity" NARROW [EC:1.97.1.11] xref: EC:1.97.1.11 xref: MetaCyc:1.97.1.11-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0033799 name: myricetin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [MetaCyc:RXN-8451] comment: Note that this term represents one of two reactions that are grouped together in EC 2.1.1.149. synonym: "CrCOMT2" RELATED [EC:2.1.1.149] synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [EC:2.1.1.149] synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [EC:2.1.1.149] xref: EC:2.1.1.149 xref: MetaCyc:RXN-8451 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033800 name: isoflavone 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone." [EC:2.1.1.150] synonym: "S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.150] xref: EC:2.1.1.150 xref: MetaCyc:RXN-6241 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033801 name: vitexin 2''-O-rhamnoside 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside." [EC:2.1.1.153] synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" EXACT [EC:2.1.1.153] xref: EC:2.1.1.153 xref: MetaCyc:RXN-4981 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033802 name: isoliquiritigenin 2'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.154, RHEA:21611] synonym: "chalcone OMT" RELATED [EC:2.1.1.154] synonym: "CHMT" RELATED [EC:2.1.1.154] synonym: "S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity" EXACT [EC:2.1.1.154] xref: EC:2.1.1.154 xref: KEGG:R07242 xref: MetaCyc:RXN-3501 xref: RHEA:21611 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033803 name: kaempferol 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H(+) + kaempferide." [EC:2.1.1.155, RHEA:15108] synonym: "F 4'-OMT" RELATED [EC:2.1.1.155] synonym: "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155] synonym: "S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155] xref: EC:2.1.1.155 xref: KEGG:R06807 xref: MetaCyc:2.1.1.155-RXN xref: RHEA:15108 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033804 name: glycine/sarcosine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reactions: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine, and S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.156] synonym: "ApGSMT" RELATED [EC:2.1.1.156] synonym: "glycine sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156] synonym: "glycine-sarcosine methyltransferase activity" EXACT [EC:2.1.1.156] synonym: "GMT" RELATED [EC:2.1.1.156] synonym: "GSMT" RELATED [EC:2.1.1.156] synonym: "S-adenosyl-L-methionine:sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156] xref: EC:2.1.1.156 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033805 name: sarcosine/dimethylglycine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reactions: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine, and S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157] synonym: "ApDMT" RELATED [EC:2.1.1.157] synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157] synonym: "sarcosine dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157] synonym: "sarcosine-dimethylglycine methyltransferase activity" EXACT [EC:2.1.1.157] synonym: "SDMT" RELATED [EC:2.1.1.157] xref: EC:2.1.1.157 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033806 name: fluorothreonine transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine." [EC:2.2.1.8] synonym: "fluoroacetaldehyde:L-threonine aldehydetransferase activity" EXACT [EC:2.2.1.8] xref: EC:2.2.1.8 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0033807 name: icosanoyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+." [EC:2.3.1.119] synonym: "acyl-CoA elongase activity" EXACT [EC:2.3.1.119] synonym: "C18-CoA elongase activity" EXACT [EC:2.3.1.119] synonym: "stearoyl-CoA elongase activity" EXACT [EC:2.3.1.119] synonym: "stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity" EXACT [EC:2.3.1.119] xref: EC:2.3.1.119 xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033808 name: 6'-deoxychalcone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O." [EC:2.3.1.170] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity" EXACT [EC:2.3.1.170] xref: EC:2.3.1.170 xref: MetaCyc:RXN-3142 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033809 name: anthocyanin 6''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)." [EC:2.3.1.171] synonym: "3MaT" RELATED [EC:2.3.1.171] synonym: "Dv3MaT" RELATED [EC:2.3.1.171] synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171] synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171] xref: EC:2.3.1.171 xref: MetaCyc:2.3.1.171-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033810 name: anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin." [EC:2.3.1.172] synonym: "malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity" EXACT [EC:2.3.1.172] synonym: "Ss5MaT1" RELATED [EC:2.3.1.172] xref: EC:2.3.1.172 xref: MetaCyc:2.3.1.172-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033811 name: flavonol-3-O-triglucoside O-coumaroyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]." [EC:2.3.1.173] synonym: "4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity" EXACT [EC:2.3.1.173] xref: EC:2.3.1.173 xref: MetaCyc:2.3.1.173-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033812 name: 3-oxoadipyl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA." [EC:2.3.1.174] synonym: "succinyl-CoA:acetyl-CoA C-succinyltransferase activity" EXACT [EC:2.3.1.174] xref: EC:2.3.1.174 xref: MetaCyc:RXN-3641 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033813 name: deacetylcephalosporin-C acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA." [EC:2.3.1.175, RHEA:23863] synonym: "acetyl coenzyme A:DAC acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:DAC acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:DAC O-acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "cefG" RELATED [EC:2.3.1.175] synonym: "CPC acetylhydrolase activity" EXACT [EC:2.3.1.175] synonym: "DAC acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "DAC-AT" RELATED [EC:2.3.1.175] synonym: "deacetylcephalosporin C acetyltransferase activity" EXACT [EC:2.3.1.175] xref: EC:2.3.1.175 xref: KEGG:R03064 xref: MetaCyc:2.3.1.175-RXN xref: RHEA:23863 is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0033814 name: propanoyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA." [EC:2.3.1.176] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.176] synonym: "peroxisomal thiolase 2 activity" NARROW [EC:2.3.1.176] synonym: "PTE-2" RELATED [EC:2.3.1.176] synonym: "SCP-X" RELATED [EC:2.3.1.176] synonym: "SCPchi" RELATED [EC:2.3.1.176] synonym: "sterol carrier protein-chi" RELATED [EC:2.3.1.176] synonym: "sterol carrier protein-X" RELATED [EC:2.3.1.176] xref: EC:2.3.1.176 xref: MetaCyc:2.3.1.176-RXN is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0033815 name: biphenyl synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2." [EC:2.3.1.177] synonym: "BIS" RELATED [EC:2.3.1.177] synonym: "malonyl-CoA:benzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.177] xref: EC:2.3.1.177 xref: MetaCyc:2.3.1.177-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033816 name: diaminobutyrate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H(+)." [EC:2.3.1.178, RHEA:16904] synonym: "2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "DAB acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "DABA acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "DABAcT" RELATED [EC:2.3.1.178] synonym: "diaminobutyric acid acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "EctA" RELATED [EC:2.3.1.178] synonym: "L-2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "L-2,4-diaminobutyrate acetyltransferase activity" EXACT [EC:2.3.1.178] xref: EC:2.3.1.178 xref: KEGG:R06978 xref: MetaCyc:R102-RXN xref: RHEA:16904 is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0033817 name: beta-ketoacyl-acyl-carrier-protein synthase II activity namespace: molecular_function def: "Catalysis of the reaction: (Z)-hexadec-11-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.179] synonym: "(Z)-hexadec-11-enoyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.179] synonym: "3-oxoacyl-acyl carrier protein synthase I activity" EXACT [EC:2.3.1.179] synonym: "beta-ketoacyl-ACP synthase II activity" EXACT [EC:2.3.1.179] synonym: "FabF" RELATED [EC:2.3.1.179] synonym: "KAS II" RELATED [EC:2.3.1.179] synonym: "KASII" RELATED [EC:2.3.1.179] xref: EC:2.3.1.179 xref: MetaCyc:2.3.1.179-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033818 name: beta-ketoacyl-acyl-carrier-protein synthase III activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2." [EC:2.3.1.180] synonym: "3-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180] synonym: "3-oxoacyl:ACP synthase III activity" EXACT [EC:2.3.1.180] synonym: "acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity" EXACT [EC:2.3.1.180] synonym: "beta-ketoacyl (acyl carrier protein) synthase III activity" EXACT [EC:2.3.1.180] synonym: "beta-ketoacyl-ACP synthase III activity" EXACT [EC:2.3.1.180] synonym: "beta-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180] synonym: "FabH" RELATED [EC:2.3.1.180] synonym: "KAS III" RELATED [EC:2.3.1.180] synonym: "KASIII" RELATED [EC:2.3.1.180] xref: EC:2.3.1.180 xref: MetaCyc:2.3.1.180-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033819 name: lipoyl(octanoyl) transferase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-[acyl-carrier protein] + protein = protein N6-(octanoyl)lysine + acyl-carrier protein." [EC:2.3.1.181] synonym: "LipB" RELATED [EC:2.3.1.181] synonym: "lipoate/octanoate transferase activity" EXACT [EC:2.3.1.181] synonym: "lipoyl (octanoyl)-acyl carrier protein:protein transferase activity" EXACT [EC:2.3.1.181] synonym: "lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity" EXACT [EC:2.3.1.181] synonym: "octanoyl-acyl carrier protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] synonym: "octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] synonym: "octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] xref: EC:2.3.1.181 xref: MetaCyc:RXN0-947 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033820 name: DNA alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.26] synonym: "T2-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] synonym: "T4-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] synonym: "T6-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] synonym: "UDP-glucose:DNA alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.26] synonym: "UDPglucose-DNA alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26] synonym: "uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26] xref: EC:2.4.1.26 xref: MetaCyc:2.4.1.26-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033821 name: DNA beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.27] synonym: "T4 phage beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "T4-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27] synonym: "T4-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27] synonym: "UDP glucose-DNA beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "UDP-glucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "UDPglucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] xref: EC:2.4.1.27 xref: MetaCyc:2.4.1.27-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033822 name: glucosyl-DNA beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA." [EC:2.4.1.28] synonym: "T6-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28] synonym: "T6-glucosyl-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28] synonym: "UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28] synonym: "UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28] synonym: "uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.28] xref: EC:2.4.1.28 xref: MetaCyc:2.4.1.28-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033823 name: procollagen glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen." [EC:2.4.1.66] synonym: "collagen glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "collagen hydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "galactosylhydroxylysine glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "galactosylhydroxylysine-glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "galactosylhydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "UDP-glucose-collagenglucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" EXACT [EC:2.4.1.66] xref: EC:2.4.1.66 xref: MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033824 name: alternansucrase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages." [EC:2.4.1.140] synonym: "sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.140] synonym: "sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.140] synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity" BROAD [EC:2.4.1.140] xref: EC:2.4.1.140 xref: MetaCyc:2.4.1.140-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033825 name: oligosaccharide 4-alpha-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides." [EC:2.4.1.161] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.161] synonym: "1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.161] synonym: "amylase III activity" EXACT [EC:2.4.1.161] xref: EC:2.4.1.161 xref: MetaCyc:2.4.1.161-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033826 name: xyloglucan 4-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage." [EC:2.4.1.168] synonym: "UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "xyloglucan 4beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "xyloglucan glucosyltransferase activity" EXACT [EC:2.4.1.168] xref: EC:2.4.1.168 xref: MetaCyc:2.4.1.168-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033827 name: high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum." [EC:2.4.1.197] synonym: "acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] synonym: "UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] synonym: "UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] synonym: "uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] xref: EC:2.4.1.197 xref: MetaCyc:2.4.1.197-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0033828 name: glucosylglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H(+)." [EC:2.4.1.213, RHEA:12884] synonym: "ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213] synonym: "ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213] synonym: "GG-phosphate synthase activity" EXACT [EC:2.4.1.213] synonym: "GGPS" RELATED [EC:2.4.1.213] synonym: "glucosyl-glycerol-phosphate synthase activity" EXACT [EC:2.4.1.213] xref: EC:2.4.1.213 xref: KEGG:R05328 xref: MetaCyc:2.4.1.213-RXN xref: RHEA:12884 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033829 name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222] synonym: "O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.222] synonym: "UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.222] xref: EC:2.4.1.222 xref: MetaCyc:2.4.1.222-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0033830 name: Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline." [EC:2.4.1.229] synonym: "Skp1-HyPro GlcNAc-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229] xref: EC:2.4.1.229 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0033831 name: kojibiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.230, RHEA:11179] synonym: "2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.230] xref: EC:2.4.1.230 xref: KEGG:R07264 xref: MetaCyc:2.4.1.230-RXN xref: RHEA:11179 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033832 name: alpha,alpha-trehalose phosphorylase (configuration-retaining) activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.231] synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.231] synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231] xref: MetaCyc:RXN-4441 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033833 name: hydroxymethylfurfural reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] xref: MetaCyc:RXN-10738 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033834 name: kaempferol 3-O-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside." [EC:2.4.1.234] synonym: "F3GalTase activity" EXACT [EC:2.4.1.234] synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.234] xref: EC:2.4.1.234 xref: MetaCyc:2.4.1.234-RXN is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0033835 name: flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]." [EC:2.4.1.236] synonym: "1->2 UDP-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] synonym: "UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] synonym: "UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] xref: EC:2.4.1.236 xref: MetaCyc:RXN-5001 xref: MetaCyc:RXN-5002 xref: MetaCyc:RXN-5004 xref: MetaCyc:RXN-7759 xref: MetaCyc:RXN-9699 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0033836 name: flavonol 7-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside." [EC:2.4.1.237] synonym: "UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.237] synonym: "UDP-glucose:flavonol 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.237] xref: EC:2.4.1.237 xref: MetaCyc:2.4.1.237-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033837 name: anthocyanin 3'-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside." [EC:2.4.1.238] synonym: "3'GT" RELATED [EC:2.4.1.238] synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.238] synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" EXACT [EC:2.4.1.238] xref: EC:2.4.1.238 xref: MetaCyc:2.4.1.238-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033838 name: flavonol-3-O-glucoside glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.239] synonym: "UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.239] xref: EC:2.4.1.239 xref: MetaCyc:2.4.1.239-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033839 name: flavonol-3-O-glycoside glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.240] synonym: "UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.240] xref: EC:2.4.1.240 xref: MetaCyc:2.4.1.240-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033840 name: NDP-glucose-starch glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1." [EC:2.4.1.242] synonym: "GBSS" RELATED [EC:2.4.1.242] synonym: "GBSSI" RELATED [EC:2.4.1.242] synonym: "GBSSII" RELATED [EC:2.4.1.242] synonym: "granule-bound starch synthase activity" EXACT [EC:2.4.1.242] synonym: "granule-bound starch synthase I activity" EXACT [EC:2.4.1.242] synonym: "granule-bound starch synthase II activity" EXACT [EC:2.4.1.242] synonym: "NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.242] synonym: "NDPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242] synonym: "starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242] synonym: "starch synthase II activity" EXACT [EC:2.4.1.242] synonym: "waxy protein" RELATED [EC:2.4.1.242] xref: EC:2.4.1.242 xref: MetaCyc:2.4.1.242-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033841 name: 6G-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)." [EC:2.4.1.243] synonym: "1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity" EXACT [EC:2.4.1.243] synonym: "6G-FFT" RELATED [EC:2.4.1.243] synonym: "6G-fructotransferase activity" EXACT [EC:2.4.1.243] synonym: "6G-FT" RELATED [EC:2.4.1.243] synonym: "fructan:fructan 6G-fructosyltransferase activity" EXACT [EC:2.4.1.243] xref: EC:2.4.1.243 xref: MetaCyc:2.4.1.243-RXN is_a: GO:0050738 ! fructosyltransferase activity [Term] id: GO:0033842 name: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244] synonym: "beta1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244] synonym: "beta1,4-N-acetylgalactosaminyltransferase III activity" EXACT [EC:2.4.1.244] synonym: "beta1,4-N-acetylgalactosaminyltransferase IV activity" EXACT [EC:2.4.1.244] synonym: "beta4GalNAc-T3" RELATED [EC:2.4.1.244] synonym: "beta4GalNAc-T4" RELATED [EC:2.4.1.244] synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244] xref: EC:2.4.1.244 xref: MetaCyc:2.4.1.244-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0033843 name: xyloglucan 6-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage." [EC:2.4.2.39] synonym: "UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39] synonym: "uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity" EXACT [EC:2.4.2.39] synonym: "xyloglucan 6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39] xref: EC:2.4.2.39 xref: MetaCyc:2.4.2.39-RXN is_a: GO:0042285 ! xylosyltransferase activity [Term] id: GO:0033844 name: galactose-6-sulfurylase activity namespace: molecular_function def: "Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues." [EC:2.5.1.5] synonym: "D-galactose-6-sulfate:alkyltransferase (cyclizing) activity" EXACT [EC:2.5.1.5] synonym: "galactose 6-sulfatase activity" EXACT [EC:2.5.1.5] synonym: "galactose-6-sulfatase activity" EXACT [EC:2.5.1.5] synonym: "porphyran sulfatase activity" EXACT [EC:2.5.1.5] xref: EC:2.5.1.5 xref: MetaCyc:2.5.1.5-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033845 name: hydroxymethylfurfural reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033846 name: adenosyl-fluoride synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine." [EC:2.5.1.63] synonym: "fluorinase activity" EXACT [EC:2.5.1.63] synonym: "S-adenosyl-L-methionine:fluoride adenosyltransferase activity" EXACT [EC:2.5.1.63] xref: EC:2.5.1.63 xref: MetaCyc:2.5.1.63-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033847 name: O-phosphoserine sulfhydrylase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate." [EC:2.5.1.65] synonym: "O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.65] synonym: "O-phosphoserine(thiol)-lyase activity" EXACT [EC:2.5.1.65] xref: EC:2.5.1.65 xref: MetaCyc:2.5.1.65-RXN xref: Reactome:261734 "O-phosphoserine sulfhydrylase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033848 name: N2-(2-carboxyethyl)arginine synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H(+) + phosphate." [EC:2.5.1.66, RHEA:10559] synonym: "CEA synthetase activity" EXACT [EC:2.5.1.66] synonym: "CEAS" RELATED [EC:2.5.1.66] synonym: "glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66] synonym: "glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66] synonym: "N2-(2-carboxyethyl)arginine synthetase activity" EXACT [EC:2.5.1.66] xref: EC:2.5.1.66 xref: KEGG:R05465 xref: MetaCyc:2.5.1.66-RXN xref: RHEA:10559 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033849 name: chrysanthemyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate." [EC:2.5.1.67, RHEA:14012] synonym: "CPPase activity" EXACT [EC:2.5.1.67] synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity" EXACT [EC:2.5.1.67] xref: EC:2.5.1.67 xref: KEGG:R08948 xref: MetaCyc:2.5.1.67-RXN xref: RHEA:14012 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033850 name: Z-farnesyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.68, RHEA:23303] synonym: "(Z)-farnesyl diphosphate synthase activity" EXACT [EC:2.5.1.68] synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity" EXACT [EC:2.5.1.68] xref: EC:2.5.1.68 xref: KEGG:R08528 xref: MetaCyc:2.5.1.68-RXN xref: RHEA:23303 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033851 name: lavandulyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate." [EC:2.5.1.69, RHEA:21679] synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity" EXACT [EC:2.5.1.69] synonym: "FDS-5" RELATED [EC:2.5.1.69] xref: EC:2.5.1.69 xref: KEGG:R08950 xref: MetaCyc:2.5.1.69-RXN xref: RHEA:21679 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033852 name: thyroid-hormone transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate." [EC:2.6.1.26, RHEA:19136] synonym: "3,5-dinitrotyrosine aminotransferase activity" EXACT [EC:2.6.1.26] synonym: "3,5-dinitrotyrosine transaminase activity" EXACT [EC:2.6.1.26] synonym: "L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.26] synonym: "thyroid hormone aminotransferase activity" EXACT [EC:2.6.1.26] synonym: "thyroid-hormone aminotransferase activity" EXACT [EC:2.6.1.26] xref: EC:2.6.1.26 xref: KEGG:R03952 xref: MetaCyc:THYROID-HORMONE-AMINOTRANSFERASE-RXN xref: RHEA:19136 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033853 name: aspartate-prephenate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate." [EC:2.6.1.78] synonym: "L-arogenate:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.78] synonym: "L-aspartate:prephenate aminotransferase activity" EXACT [EC:2.6.1.78] synonym: "PAT" RELATED [EC:2.6.1.78] synonym: "prephenate aspartate aminotransferase activity" EXACT [EC:2.6.1.78] synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.78] xref: EC:2.6.1.78 xref: MetaCyc:PREPHENATE-ASP-TRANSAMINE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033854 name: glutamate-prephenate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate." [EC:2.6.1.79, RHEA:22883] synonym: "L-arogenate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.79] synonym: "L-glutamate:prephenate aminotransferase activity" EXACT [EC:2.6.1.79] synonym: "PAT" RELATED [EC:2.6.1.79] synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.79] xref: EC:2.6.1.79 xref: KEGG:R07276 xref: MetaCyc:PREPHENATE-TRANSAMINE-RXN xref: RHEA:22883 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033855 name: nicotianamine aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate." [EC:2.6.1.80, RHEA:22107] synonym: "NAAT" RELATED [EC:2.6.1.80] synonym: "NAAT-I" RELATED [EC:2.6.1.80] synonym: "NAAT-II" RELATED [EC:2.6.1.80] synonym: "NAAT-III" RELATED [EC:2.6.1.80] synonym: "nicotianamine transaminase activity" EXACT [EC:2.6.1.80] synonym: "nicotianamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.80] xref: EC:2.6.1.80 xref: KEGG:R07277 xref: MetaCyc:2.6.1.80-RXN xref: RHEA:22107 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033856 name: pyridoxine 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H(2)O + H(+) + phosphate + pyridoxine 5'-phosphate." [EC:2.6.99.2, RHEA:15268] synonym: "1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity" EXACT [EC:2.6.99.2] synonym: "PdxJ" RELATED [EC:2.6.99.2] synonym: "PNP synthase activity" EXACT [EC:2.6.99.2] synonym: "pyridoxine 5-phosphate phospho lyase activity" EXACT [EC:2.6.99.2] xref: EC:2.6.99.2 xref: KEGG:R05838 xref: MetaCyc:PDXJ-RXN xref: RHEA:15268 is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0033857 name: diphosphoinositol-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate." [EC:2.7.4.24] synonym: "ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.24] synonym: "PP-InsP5 kinase activity" EXACT [EC:2.7.4.24] synonym: "PP-IP5 kinase activity" EXACT [EC:2.7.4.24] synonym: "PPIP5K" RELATED [EC:2.7.4.24] synonym: "PPIP5K1" RELATED [EC:2.7.4.24] synonym: "PPIP5K2" RELATED [EC:2.7.4.24] synonym: "VIP1" NARROW [EC:2.7.4.24] synonym: "VIP2" NARROW [EC:2.7.4.24] xref: EC:2.7.4.24 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0033858 name: N-acetylgalactosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157] synonym: "ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity" EXACT [EC:2.7.1.157] synonym: "GALK2" RELATED [EC:2.7.1.157] synonym: "GalNAc kinase activity" EXACT [EC:2.7.1.157] synonym: "GK2" RELATED [EC:2.7.1.157] synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" EXACT [EC:2.7.1.157] xref: EC:2.7.1.157 xref: MetaCyc:2.7.1.157-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0033859 name: furaldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass." [GOC:jp, PMID:15338422, PMID:16652391] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0033860 name: regulation of NAD(P)H oxidase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme NAD(P)H oxidase." [GOC:mah] is_a: GO:0051341 ! regulation of oxidoreductase activity [Term] id: GO:0033861 name: negative regulation of NAD(P)H oxidase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme NAD(P)H oxidase." [GOC:mah] subset: gosubset_prok synonym: "down regulation of NAD(P)H oxidase activity" EXACT [] synonym: "down-regulation of NAD(P)H oxidase activity" EXACT [] synonym: "downregulation of NAD(P)H oxidase activity" EXACT [] synonym: "inhibition of NAD(P)H oxidase activity" NARROW [] is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity is_a: GO:0051354 ! negative regulation of oxidoreductase activity [Term] id: GO:0033862 name: UMP kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UMP = ADP + UDP." [EC:2.7.4.22] synonym: "ATP:UMP phosphotransferase activity" EXACT [EC:2.7.4.22] synonym: "PyrH" RELATED [EC:2.7.4.22] synonym: "SmbA" RELATED [EC:2.7.4.22] synonym: "UMP-kinase activity" EXACT [EC:2.7.4.22] synonym: "UMPK" RELATED [EC:2.7.4.22] synonym: "uridine monophosphate kinase activity" EXACT [EC:2.7.4.22] xref: EC:2.7.4.22 xref: MetaCyc:2.7.4.22-RXN is_a: GO:0009041 ! uridylate kinase activity [Term] id: GO:0033863 name: ribose 1,5-bisphosphate phosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H(+)." [EC:2.7.4.23, RHEA:20112] synonym: "ATP:ribose-1,5-bisphosphate phosphotransferase activity" EXACT [EC:2.7.4.23] synonym: "PhnN" RELATED [EC:2.7.4.23] synonym: "ribose 1,5-bisphosphokinase activity" EXACT [EC:2.7.4.23] xref: EC:2.7.4.23 xref: KEGG:R06836 xref: MetaCyc:2.7.4.23-RXN xref: RHEA:20112 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0033864 name: positive regulation of NAD(P)H oxidase activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme NAD(P)H oxidase." [GOC:mah] subset: gosubset_prok synonym: "activation of NAD(P)H oxidase activity" NARROW [] synonym: "stimulation of NAD(P)H oxidase activity" NARROW [] synonym: "up regulation of NAD(P)H oxidase activity" EXACT [] synonym: "up-regulation of NAD(P)H oxidase activity" EXACT [] synonym: "upregulation of NAD(P)H oxidase activity" EXACT [] is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity is_a: GO:0051353 ! positive regulation of oxidoreductase activity [Term] id: GO:0033865 name: nucleoside bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "nucleoside bisphosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0033866 name: nucleoside bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "nucleoside bisphosphate anabolism" EXACT [] synonym: "nucleoside bisphosphate biosynthesis" EXACT [] synonym: "nucleoside bisphosphate formation" EXACT [] synonym: "nucleoside bisphosphatehate synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0033865 ! nucleoside bisphosphate metabolic process [Term] id: GO:0033867 name: Fas-activated serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8] synonym: "ATP:Fas-activated serine/threonine protein phosphotransferase activity" EXACT [EC:2.7.11.8] synonym: "FAST" RELATED [EC:2.7.11.8] synonym: "FASTK" RELATED [EC:2.7.11.8] synonym: "STK10" RELATED [EC:2.7.11.8] xref: EC:2.7.11.8 xref: MetaCyc:2.7.11.8-RXN is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0033868 name: Goodpasture-antigen-binding protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9] synonym: "ATP:Goodpasture antigen-binding protein phosphotransferase activity" EXACT [EC:2.7.11.9] synonym: "Goodpasture antigen-binding protein kinase activity" EXACT [EC:2.7.11.9] synonym: "GPBP kinase activity" EXACT [EC:2.7.11.9] synonym: "GPBPK" RELATED [EC:2.7.11.9] synonym: "STK11" RELATED [EC:2.7.11.9] xref: EC:2.7.11.9 xref: MetaCyc:2.7.11.9-RXN is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0033869 name: nucleoside bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "nucleoside bisphosphate breakdown" EXACT [] synonym: "nucleoside bisphosphate catabolism" EXACT [] synonym: "nucleoside bisphosphate degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0033865 ! nucleoside bisphosphate metabolic process [Term] id: GO:0033870 name: thiol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate." [EC:2.8.2.16] synonym: "3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity" EXACT [EC:2.8.2.16] synonym: "adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity" EXACT [EC:2.8.2.16] synonym: "PAPS sulfotransferase activity" BROAD [EC:2.8.2.16] xref: EC:2.8.2.16 xref: MetaCyc:THIOL-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0033871 name: [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "3-OST-2" RELATED [EC:2.8.2.29] synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29] synonym: "glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "heparin-glucosamine 3-sulfotransferase 2 activity" RELATED [] synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29] xref: EC:2.8.2.29 xref: MetaCyc:2.8.2.29-RXN is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0033872 name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate." [EC:2.8.2.30] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30] synonym: "3-OST-3" RELATED [EC:2.8.2.30] synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30] synonym: "glucosaminyl 3-O-sulfotransferase 3a, 3b activity" EXACT [EC:2.8.2.30] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity" EXACT [EC:2.8.2.30] synonym: "heparin-glucosamine 3-sulfotransferase 3 activity" RELATED [] synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30] xref: EC:2.8.2.30 xref: MetaCyc:2.8.2.30-RXN is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0033873 name: petromyzonol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.31, RHEA:17000] synonym: "3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity" EXACT [EC:2.8.2.31] synonym: "PZ-SULT" RELATED [EC:2.8.2.31] xref: EC:2.8.2.31 xref: KEGG:R07797 xref: MetaCyc:2.8.2.31-RXN xref: RHEA:17000 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0033874 name: scymnol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.32, RHEA:15480] xref: EC:2.8.2.32 xref: KEGG:R07798 xref: MetaCyc:2.8.2.32-RXN xref: RHEA:15480 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0033875 name: ribonucleoside bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "ribonucleoside bisphosphate metabolism" EXACT [] is_a: GO:0033865 ! nucleoside bisphosphate metabolic process [Term] id: GO:0033876 name: glycochenodeoxycholate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H(+)." [EC:2.8.2.34, RHEA:17692] synonym: "3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity" EXACT [EC:2.8.2.34] synonym: "BAST" RELATED [EC:2.8.2.34] synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" BROAD [EC:2.8.2.34] synonym: "bile acid:PAPS:sulfotransferase activity" EXACT [EC:2.8.2.34] xref: EC:2.8.2.34 xref: KEGG:R07289 xref: MetaCyc:2.8.2.34-RXN xref: RHEA:17692 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0033877 name: succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity namespace: molecular_function alt_id: GO:0018728 def: "Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate." [EC:2.8.3.15, RHEA:16472] synonym: "benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15] synonym: "succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15] synonym: "succinyl-CoA:benzylsuccinate CoA-transferase activity" EXACT [] xref: EC:2.8.3.15 xref: KEGG:R05588 xref: MetaCyc:RXN-864 xref: RHEA:16472 xref: UM-BBD_reactionID:r0329 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0033878 name: hormone-sensitive lipase activity namespace: molecular_function def: "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79] synonym: "diacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.79] synonym: "HSL" RELATED [EC:3.1.1.79] xref: EC:3.1.1.79 xref: MetaCyc:STEROL-ESTERASE-RXN xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0033879 name: acetylajmaline esterase activity namespace: molecular_function def: "Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate." [EC:3.1.1.80] synonym: "17-O-acetylajmaline O-acetylhydrolase activity" EXACT [EC:3.1.1.80] synonym: "2beta(R)-17-O-acetylajmalan:acetylesterase activity" EXACT [EC:3.1.1.80] synonym: "AAE" RELATED [EC:3.1.1.80] synonym: "acetylajmalan esterase activity" EXACT [EC:3.1.1.80] xref: EC:3.1.1.80 xref: MetaCyc:RXN-8652 xref: MetaCyc:RXN-8653 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0033880 name: phenylacetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate." [EC:3.1.2.25, RHEA:15340] synonym: "phenylglyoxylyl-CoA hydrolase activity" EXACT [EC:3.1.2.25] xref: EC:3.1.2.25 xref: KEGG:R07294 xref: MetaCyc:3.1.2.25-RXN xref: RHEA:15340 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0033881 name: bile-acid-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deoxycholoyl-CoA + H(2)O = CoA + deoxycholate + H(+)." [EC:3.1.2.26, RHEA:17696] synonym: "bile acid-coenzyme A hydrolase activity" EXACT [EC:3.1.2.26] synonym: "deoxycholoyl-CoA hydrolase activity" EXACT [EC:3.1.2.26] xref: EC:3.1.2.26 xref: KEGG:R07295 xref: MetaCyc:BACOAHYDRO-RXN xref: RHEA:17696 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0033882 name: choloyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA." [EC:3.1.2.27] synonym: "chenodeoxycholoyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27] synonym: "choloyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27] synonym: "peroxisomal acyl-CoA thioesterase 2 activity" NARROW [EC:3.1.2.27] synonym: "PTE-2" RELATED [EC:3.1.2.27] xref: EC:3.1.2.27 xref: MetaCyc:3.1.2.27-RXN is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0033883 name: pyridoxal phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74] synonym: "PLP phosphatase activity" EXACT [EC:3.1.3.74] synonym: "PNP phosphatase activity" EXACT [EC:3.1.3.74] synonym: "pyridoxal-5'-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.74] synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74] synonym: "vitamine B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74] xref: EC:3.1.3.74 xref: MetaCyc:3.1.3.74-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0033884 name: phosphoethanolamine/phosphocholine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate, and phosphocholine + H2O = choline + phosphate." [EC:3.1.3.75] synonym: "3X11A" RELATED [EC:3.1.3.75] synonym: "PHOSPHO1" RELATED [EC:3.1.3.75] synonym: "phosphoethanolamine phosphohydrolase activity" EXACT [EC:3.1.3.75] xref: EC:3.1.3.75 xref: MetaCyc:RXN-5647 xref: MetaCyc:RXN-7948 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0033885 name: lipid-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate." [EC:3.1.3.76, RHEA:16540] synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity" EXACT [EC:3.1.3.76] synonym: "dihydroxy fatty acid phosphatase activity" EXACT [EC:3.1.3.76] synonym: "hydroxy fatty acid phosphatase activity" EXACT [EC:3.1.3.76] synonym: "hydroxy lipid phosphatase activity" EXACT [EC:3.1.3.76] synonym: "sEH" RELATED [EC:3.1.3.76] synonym: "soluble epoxide hydrolase activity" RELATED [EC:3.1.3.76] xref: EC:3.1.3.76 xref: KEGG:R07582 xref: MetaCyc:3.1.3.76-RXN xref: RHEA:16540 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0033886 name: cellulose-polysulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin." [EC:3.1.6.7] synonym: "cellulose-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.7] xref: EC:3.1.6.7 xref: MetaCyc:3.1.6.7-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0033887 name: chondro-4-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate." [EC:3.1.6.9, RHEA:11447] synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.9] xref: EC:3.1.6.9 xref: KEGG:R03517 xref: MetaCyc:CHONDRO-4-SULFATASE-RXN xref: RHEA:11447 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0033888 name: chondro-6-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate." [EC:3.1.6.10, RHEA:10539] synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.10] xref: EC:3.1.6.10 xref: KEGG:R03518 xref: MetaCyc:CHONDRO-6-SULFATASE-RXN xref: RHEA:10539 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0033889 name: N-sulfoglucosamine-3-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin." [EC:3.1.6.15] synonym: "chondroitinsulfatase activity" BROAD [EC:3.1.6.15] synonym: "N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity" EXACT [EC:3.1.6.15] xref: EC:3.1.6.15 xref: MetaCyc:3.1.6.15-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0033890 name: ribonuclease D activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides." [EC:3.1.13.5] synonym: "RNase D activity" EXACT [EC:3.1.13.5] xref: EC:3.1.13.5 xref: MetaCyc:3.1.13.5-RXN is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033891 name: CC-preferring endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC." [EC:3.1.21.6] synonym: "5'-CC-3'-preferring endodeoxyribonuclease activity" EXACT [EC:3.1.21.6] synonym: "Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity" EXACT [EC:3.1.21.6] synonym: "Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity" EXACT [EC:3.1.21.6] synonym: "Streptomyces glaucescens exocytoplasmic endonuclease activity" EXACT [EC:3.1.21.6] xref: EC:3.1.21.6 xref: MetaCyc:3.1.21.6-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033892 name: deoxyribonuclease (pyrimidine dimer) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.1] synonym: "bacteriophage T4 endodeoxyribonuclease V activity" EXACT [EC:3.1.25.1] synonym: "endodeoxyribonuclease (pyrimidine dimer) activity" EXACT [EC:3.1.25.1] synonym: "T4 endonuclease V activity" EXACT [EC:3.1.25.1] xref: EC:3.1.25.1 xref: MetaCyc:3.1.25.1-RXN is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base [Term] id: GO:0033893 name: ribonuclease IV activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.6] synonym: "endoribonuclease IV activity" EXACT [EC:3.1.26.6] xref: EC:3.1.26.6 xref: MetaCyc:3.1.26.6-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033894 name: ribonuclease P4 activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor." [EC:3.1.26.7] xref: EC:3.1.26.7 xref: MetaCyc:3.1.26.7-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033895 name: ribonuclease [poly-(U)-specific] activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.9] synonym: "ribonuclease (uracil-specific) activity" EXACT [EC:3.1.26.9] synonym: "uracil-specific endoribonuclease activity" EXACT [EC:3.1.26.9] synonym: "uracil-specific RNase activity" EXACT [EC:3.1.26.9] xref: EC:3.1.26.9 is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033896 name: ribonuclease IX activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.10] synonym: "poly(U)- and poly(C)-specific endoribonuclease activity" EXACT [EC:3.1.26.10] xref: EC:3.1.26.10 xref: MetaCyc:3.1.26.10-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033897 name: ribonuclease T2 activity namespace: molecular_function def: "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.1] synonym: "acid ribonuclease activity" EXACT [EC:3.1.27.1] synonym: "acid RNase activity" EXACT [EC:3.1.27.1] synonym: "base-non-specific ribonuclease activity" EXACT [EC:3.1.27.1] synonym: "Escherichia coli ribonuclease I' ribonuclease PP2 activity" EXACT [EC:3.1.27.1] synonym: "Escherichia coli ribonuclease II activity" EXACT [EC:3.1.27.1] synonym: "non-base specific ribonuclease activity" EXACT [EC:3.1.27.1] synonym: "nonbase-specific RNase activity" EXACT [EC:3.1.27.1] synonym: "nonspecific RNase activity" EXACT [EC:3.1.27.1] synonym: "ribonnuclease (non-base specific) activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease (non-base specific) activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease II activity" BROAD [EC:3.1.27.1] synonym: "ribonuclease M activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease N2 activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease PP3 activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease U4 activity" EXACT [EC:3.1.27.1] synonym: "ribonucleate 3'-oligonucleotide hydrolase activity" EXACT [EC:3.1.27.1] synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.1] synonym: "RNAase CL activity" EXACT [EC:3.1.27.1] synonym: "RNase (non-base specific) activity" EXACT [EC:3.1.27.1] synonym: "RNase II activity" BROAD [EC:3.1.27.1] synonym: "RNase M activity" EXACT [EC:3.1.27.1] synonym: "RNase Ms activity" EXACT [EC:3.1.27.1] synonym: "RNase T2 activity" EXACT [EC:3.1.27.1] xref: EC:3.1.27.1 xref: MetaCyc:3.1.27.1-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033898 name: Bacillus subtilis ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides." [EC:3.1.27.2] synonym: "proteus mirabilis RNase activity" EXACT [EC:3.1.27.2] synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.2] xref: EC:3.1.27.2 xref: MetaCyc:3.1.27.2-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033899 name: ribonuclease U2 activity namespace: molecular_function def: "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.4] synonym: "pleospora RNase activity" EXACT [EC:3.1.27.4] synonym: "purine specific endoribonuclease activity" EXACT [EC:3.1.27.4] synonym: "purine-specific ribonuclease activity" EXACT [EC:3.1.27.4] synonym: "purine-specific RNase activity" EXACT [EC:3.1.27.4] synonym: "ribonuclease (purine) activity" EXACT [EC:3.1.27.4] synonym: "ribonuclease U3 activity" EXACT [EC:3.1.27.4] synonym: "RNase U3 activity" EXACT [EC:3.1.27.4] synonym: "trichoderma koningi RNase III activity" EXACT [EC:3.1.27.4] xref: EC:3.1.27.4 xref: MetaCyc:3.1.27.4-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033900 name: ribonuclease F activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups." [EC:3.1.27.7] synonym: "ribonuclease F (E. coli) activity" EXACT [EC:3.1.27.7] synonym: "RNase F activity" EXACT [EC:3.1.27.7] xref: EC:3.1.27.7 xref: MetaCyc:3.1.27.7-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033901 name: ribonuclease V activity namespace: molecular_function def: "Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP." [EC:3.1.27.8] synonym: "endoribonuclease V activity" EXACT [EC:3.1.27.8] xref: EC:3.1.27.8 xref: MetaCyc:3.1.27.8-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033902 name: rRNA endonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes." [EC:3.1.27.10] synonym: "alpha-sarcin" RELATED [EC:3.1.27.10] xref: EC:3.1.27.10 xref: MetaCyc:3.1.27.10-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033903 name: endo-1,3(4)-beta-glucanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6] synonym: "1,3-(1,3;1,4)-beta-D-glucan 3(4)-glucanohydrolase activity" EXACT [EC:3.2.1.6] synonym: "beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6] synonym: "beta-1,3-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-1,3-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.6] synonym: "endo-1,3-beta-D-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-1,3-beta-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-beta-(1-3)-D-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-beta-(1->3)-D-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-beta-1,3(4)-glucanase activity" EXACT [EC:3.2.1.6] synonym: "endo-beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6] synonym: "endo-beta-1,3-glucanase IV activity" EXACT [EC:3.2.1.6] synonym: "laminaranase activity" BROAD [EC:3.2.1.6] synonym: "laminarinase activity" BROAD [EC:3.2.1.6] xref: EC:3.2.1.6 xref: MetaCyc:3.2.1.6-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033904 name: dextranase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran." [EC:3.2.1.11] synonym: "1,6-alpha-D-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.11] synonym: "alpha-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11] synonym: "alpha-D-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11] synonym: "dextran hydrolase activity" EXACT [EC:3.2.1.11] synonym: "dextranase DL 2 activity" NARROW [EC:3.2.1.11] synonym: "DL 2" RELATED [EC:3.2.1.11] synonym: "endo-dextranase activity" EXACT [EC:3.2.1.11] synonym: "endodextranase activity" EXACT [EC:3.2.1.11] xref: EC:3.2.1.11 xref: MetaCyc:3.2.1.11-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033905 name: xylan endo-1,3-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,3-beta-D-glycosidic linkages in 1,3-beta-D-xylans." [EC:3.2.1.32] synonym: "1,3-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.32] synonym: "1,3-beta-xylanase activity" EXACT [EC:3.2.1.32] synonym: "1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "beta-1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "endo-1,3-beta-xylanase activity" EXACT [EC:3.2.1.32] synonym: "endo-1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "endo-beta-1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "xylanase activity" BROAD [EC:3.2.1.32] xref: EC:3.2.1.32 xref: MetaCyc:3.2.1.32-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033906 name: hyaluronoglucuronidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate." [EC:3.2.1.36] synonym: "glucuronoglucosaminoglycan hyaluronate lyase activity" EXACT [EC:3.2.1.36] synonym: "hyaluronate 3-glycanohydrolase activity" EXACT [EC:3.2.1.36] synonym: "hyaluronidase activity" BROAD [EC:3.2.1.36] synonym: "orgelase activity" EXACT [EC:3.2.1.36] xref: EC:3.2.1.36 xref: MetaCyc:3.2.1.36-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033907 name: beta-D-fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides." [EC:3.2.1.38] synonym: "beta-D-fucoside fucohydrolase activity" EXACT [EC:3.2.1.38] synonym: "beta-fucosidase activity" EXACT [EC:3.2.1.38] xref: EC:3.2.1.38 xref: MetaCyc:3.2.1.38-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033908 name: beta-L-rhamnosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides." [EC:3.2.1.43] synonym: "beta-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.43] xref: EC:3.2.1.43 xref: MetaCyc:3.2.1.43-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033909 name: fucoidanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate." [EC:3.2.1.44] synonym: "poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity" EXACT [EC:3.2.1.44] xref: EC:3.2.1.44 xref: MetaCyc:3.2.1.44-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033910 name: glucan 1,4-alpha-maltotetraohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends." [EC:3.2.1.60] synonym: "1,4-alpha-D-glucan maltotetraohydrolase activity" EXACT [EC:3.2.1.60] synonym: "exo-maltotetraohydrolase activity" EXACT [EC:3.2.1.60] synonym: "G4-amylase activity" EXACT [EC:3.2.1.60] synonym: "glucan 1,4-alpha-maltotetrahydrolase activity" EXACT [EC:3.2.1.60] synonym: "maltotetraose-forming amylase activity" EXACT [EC:3.2.1.60] xref: EC:3.2.1.60 xref: MetaCyc:3.2.1.60-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033911 name: mycodextranase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds." [EC:3.2.1.61] synonym: "1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.61] xref: EC:3.2.1.61 xref: MetaCyc:3.2.1.61-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033912 name: 2,6-beta-fructan 6-levanbiohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 2,6-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain." [EC:3.2.1.64] synonym: "2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity" EXACT [EC:3.2.1.64] synonym: "2,6-beta-D-fructan 6-levanbiohydrolase activity" EXACT [EC:3.2.1.64] synonym: "2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity" EXACT [EC:3.2.1.64] synonym: "beta-2,6-fructan-6-levanbiohydrolase activity" EXACT [EC:3.2.1.64] synonym: "levanbiose-producing levanase activity" EXACT [EC:3.2.1.64] xref: EC:3.2.1.64 xref: MetaCyc:3.2.1.64-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033913 name: glucan endo-1,2-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,2-glucosidic linkages in 1,2-beta-D-glucans." [EC:3.2.1.71] synonym: "1,2-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.71] synonym: "beta-D-1,2-glucanase activity" EXACT [EC:3.2.1.71] synonym: "endo-(1->2)-beta-D-glucanase activity" EXACT [EC:3.2.1.71] synonym: "endo-1,2-beta-glucanase activity" EXACT [EC:3.2.1.71] xref: EC:3.2.1.71 xref: MetaCyc:3.2.1.71-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0033914 name: xylan 1,3-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of 1,3-beta-D-xylans." [EC:3.2.1.72] synonym: "1,3-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.72] synonym: "1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72] synonym: "beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72] synonym: "exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72] synonym: "exo-beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72] xref: EC:3.2.1.72 xref: MetaCyc:3.2.1.72-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033915 name: mannan 1,2-(1,3)-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,2- and 1,3-linkages in yeast mannan, releasing mannose." [EC:3.2.1.77] synonym: "1,2-1,3-alpha-D-mannan mannohydrolase activity" EXACT [EC:3.2.1.77] synonym: "exo-1,2-1,3-alpha-mannosidase activity" EXACT [EC:3.2.1.77] xref: EC:3.2.1.77 xref: MetaCyc:3.2.1.77-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0033916 name: beta-agarase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product." [EC:3.2.1.81] synonym: "AgaA" RELATED [EC:3.2.1.81] synonym: "AgaB" RELATED [EC:3.2.1.81] synonym: "agarase activity" BROAD [EC:3.2.1.81] synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.81] synonym: "agarose 4-glycanohydrolase activity" EXACT [EC:3.2.1.81] xref: EC:3.2.1.81 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033917 name: exo-poly-alpha-galacturonosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate." [EC:3.2.1.82] synonym: "exopolygalacturanosidase activity" EXACT [EC:3.2.1.82] synonym: "exopolygalacturonosidase activity" EXACT [EC:3.2.1.82] xref: EC:3.2.1.82 xref: MetaCyc:3.2.1.82-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033918 name: kappa-carrageenase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans." [EC:3.2.1.83] synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity" EXACT [EC:3.2.1.83] synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase activity" EXACT [EC:3.2.1.83] xref: EC:3.2.1.83 xref: MetaCyc:3.2.1.83-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033919 name: glucan 1,3-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal 1,3-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84] synonym: "1,3-alpha-D-glucan 3-glucohydrolase activity" EXACT [EC:3.2.1.84] synonym: "exo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.84] synonym: "glucosidase II activity" EXACT [EC:3.2.1.84] xref: EC:3.2.1.84 xref: MetaCyc:3.2.1.84-RXN xref: Reactome:259489 "glucan 1,3-alpha-glucosidase activity" is_a: GO:0004558 ! alpha-glucosidase activity [Term] id: GO:0033920 name: 6-phospho-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol." [EC:3.2.1.85] synonym: "6-phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85] synonym: "6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity" EXACT [EC:3.2.1.85] synonym: "beta-D-phosphogalactoside galactohydrolase activity" EXACT [EC:3.2.1.85] synonym: "phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85] synonym: "phospho-beta-galactosidase activity" EXACT [EC:3.2.1.85] xref: EC:3.2.1.85 xref: MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033921 name: capsular-polysaccharide endo-1,3-alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,3-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide." [EC:3.2.1.87] synonym: "aerobacter-capsular-polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87] synonym: "capsular polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87] synonym: "polysaccharide depolymerase activity" EXACT [EC:3.2.1.87] xref: EC:3.2.1.87 xref: MetaCyc:3.2.1.87-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033922 name: peptidoglycan beta-N-acetylmuramidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues." [EC:3.2.1.92] synonym: "beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity" EXACT [EC:3.2.1.92] synonym: "exo-beta-acetylmuramidase activity" EXACT [EC:3.2.1.92] synonym: "exo-beta-N-acetylmuramidase activity" EXACT [EC:3.2.1.92] synonym: "peptidoglycan beta-N-acetylmuramoylexohydrolase activity" EXACT [EC:3.2.1.92] xref: EC:3.2.1.92 xref: MetaCyc:3.2.1.92-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033923 name: glucan 1,6-alpha-isomaltosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains." [EC:3.2.1.94] synonym: "1,6-alpha-D-glucan isomaltohydrolase activity" EXACT [EC:3.2.1.94] synonym: "exo-isomaltohydrolase activity" EXACT [EC:3.2.1.94] synonym: "G2-dextranase activity" EXACT [EC:3.2.1.94] synonym: "isomalto-dextranase activity" EXACT [EC:3.2.1.94] synonym: "isomaltodextranase activity" EXACT [EC:3.2.1.94] xref: EC:3.2.1.94 xref: MetaCyc:3.2.1.94-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033924 name: dextran 1,6-alpha-isomaltotriosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains." [EC:3.2.1.95] synonym: "1,6-alpha-D-glucan isomaltotriohydrolase activity" EXACT [EC:3.2.1.95] synonym: "exo-isomaltotriohydrolase activity" EXACT [EC:3.2.1.95] xref: EC:3.2.1.95 xref: MetaCyc:3.2.1.95-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033925 name: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96] synonym: "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-(1->4)-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase D activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase F activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase H activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase L activity" EXACT [EC:3.2.1.96] synonym: "endo-N-acetyl-beta-D-glucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endoglycosidase H activity" EXACT [EC:3.2.1.96] synonym: "endoglycosidase S activity" EXACT [EC:3.2.1.96] synonym: "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96] synonym: "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96] synonym: "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity" EXACT [EC:3.2.1.96] synonym: "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity" EXACT [EC:3.2.1.96] synonym: "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] xref: EC:3.2.1.96 xref: MetaCyc:3.2.1.96-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033926 name: glycopeptide alpha-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine." [EC:3.2.1.97, MetaCyc:3.2.1.97-RXN] synonym: "D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity" EXACT [EC:3.2.1.97] synonym: "endo-alpha-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97] synonym: "endo-alpha-N-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97] xref: EC:3.2.1.97 xref: MetaCyc:3.2.1.97-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033927 name: glucan 1,4-alpha-maltohexaosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends." [EC:3.2.1.98] synonym: "1,4-alpha-D-glucan maltohexaohydrolase activity" EXACT [EC:3.2.1.98] synonym: "exo-maltohexaohydrolase activity" EXACT [EC:3.2.1.98] synonym: "G6-amylase activity" EXACT [EC:3.2.1.98] synonym: "maltohexaose-producing amylase activity" EXACT [EC:3.2.1.98] xref: EC:3.2.1.98 xref: MetaCyc:3.2.1.98-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033928 name: mannan 1,4-mannobiosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-mannosidic linkages in 1,4-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends." [EC:3.2.1.100] synonym: "1,4-beta-D-mannan mannobiohydrolase activity" BROAD [EC:3.2.1.100] synonym: "exo-1,4-beta-mannobiohydrolase activity" EXACT [EC:3.2.1.100] synonym: "exo-beta-mannanase activity" EXACT [EC:3.2.1.100] synonym: "mannan 1,4-beta-mannobiosidase activity" EXACT [EC:3.2.1.100] xref: EC:3.2.1.100 xref: MetaCyc:3.2.1.100-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033929 name: blood-group-substance endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-galactosidic linkages in blood group A and B substances." [EC:3.2.1.102] synonym: "blood-group-substance 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.102] synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.102] xref: EC:3.2.1.102 xref: MetaCyc:3.2.1.102-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033930 name: keratan-sulfate endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-galactosidic linkages in keratan sulfate." [EC:3.2.1.103] synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.103] synonym: "keratan sulfate endogalactosidase activity" EXACT [EC:3.2.1.103] synonym: "keratan-sulfate 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.103] synonym: "keratanase activity" EXACT [EC:3.2.1.103] xref: EC:3.2.1.103 xref: MetaCyc:3.2.1.103-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033931 name: endogalactosaminidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-alpha-D-galactosaminidic linkages in poly(D-galactosamine)." [EC:3.2.1.109] synonym: "galactosaminoglycan glycanohydrolase activity" EXACT [EC:3.2.1.109] xref: EC:3.2.1.109 xref: MetaCyc:3.2.1.109-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033932 name: 1,3-alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,3-linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111] synonym: "3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity" EXACT [EC:3.2.1.111] synonym: "almond emulsin fucosidase I activity" EXACT [EC:3.2.1.111] xref: EC:3.2.1.111 xref: MetaCyc:3.2.1.111-RXN is_a: GO:0004560 ! alpha-L-fucosidase activity [Term] id: GO:0033933 name: branched-dextran exo-1,2-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,2-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose." [EC:3.2.1.115] synonym: "1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity" EXACT [EC:3.2.1.115] synonym: "dextran 1,2-alpha-glucosidase activity" EXACT [EC:3.2.1.115] synonym: "dextran alpha-1,2 debranching enzyme" RELATED [EC:3.2.1.115] xref: EC:3.2.1.115 xref: MetaCyc:3.2.1.115-RXN is_a: GO:0004558 ! alpha-glucosidase activity [Term] id: GO:0033934 name: glucan 1,4-alpha-maltotriohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends." [EC:3.2.1.116] synonym: "1,4-alpha-D-glucan maltotriohydrolase activity" EXACT [EC:3.2.1.116] synonym: "exo-maltotriohydrolase activity" EXACT [EC:3.2.1.116] synonym: "maltotriohydrolase activity" EXACT [EC:3.2.1.116] xref: EC:3.2.1.116 xref: MetaCyc:3.2.1.116-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033935 name: oligoxyloglucan beta-glycosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends." [EC:3.2.1.120] synonym: "isoprimeverose-producing oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120] synonym: "oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120] synonym: "oligoxyloglucan xyloglucohydrolase activity" EXACT [EC:3.2.1.120] xref: EC:3.2.1.120 xref: MetaCyc:3.2.1.120-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0033936 name: polymannuronate hydrolase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate." [EC:3.2.1.121] synonym: "poly(mannuronide) mannuronohydrolase activity" EXACT [EC:3.2.1.121] synonym: "polymannuronic acid polymerase activity" EXACT [EC:3.2.1.121] xref: EC:3.2.1.121 xref: MetaCyc:3.2.1.121-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033937 name: 3-deoxy-2-octulosonidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides." [EC:3.2.1.124] synonym: "2-keto-3-deoxyoctonate hydrolase activity" EXACT [EC:3.2.1.124] synonym: "capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity" EXACT [EC:3.2.1.124] synonym: "octulofuranosylono hydrolase activity" EXACT [EC:3.2.1.124] synonym: "octulopyranosylonohydrolase activity" EXACT [EC:3.2.1.124] synonym: "octulosylono hydrolase activity" EXACT [EC:3.2.1.124] xref: EC:3.2.1.124 xref: MetaCyc:3.2.1.124-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033938 name: 1,6-alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,6-linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin." [EC:3.2.1.127] synonym: "1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity" EXACT [EC:3.2.1.127] xref: EC:3.2.1.127 xref: MetaCyc:3.2.1.127-RXN is_a: GO:0004560 ! alpha-L-fucosidase activity [Term] id: GO:0033939 name: xylan alpha-1,2-glucuronosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-D-1,2-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans." [EC:3.2.1.131] synonym: "1,2-alpha-glucuronidase activity" EXACT [EC:3.2.1.131] synonym: "alpha-(1->2)-glucuronidase activity" EXACT [EC:3.2.1.131] synonym: "xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity" EXACT [EC:3.2.1.131] xref: EC:3.2.1.131 xref: MetaCyc:3.2.1.131-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033940 name: glucuronoarabinoxylan endo-1,4-beta-xylanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-xylosyl links in some glucuronoarabinoxylans." [EC:3.2.1.136] synonym: "endoarabinoxylanase activity" EXACT [EC:3.2.1.136] synonym: "feraxan endoxylanase activity" EXACT [EC:3.2.1.136] synonym: "feraxanase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoxylan xylanohydrolase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoxylan xylohydrolase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoxylanase activity" EXACT [EC:3.2.1.136] xref: EC:3.2.1.136 xref: MetaCyc:3.2.1.136-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033941 name: mannan exo-1,2-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,2-alpha-D- and 1,6-alpha-D- linkages in yeast mannan, releasing D-mannose." [EC:3.2.1.137] synonym: "1,2-1,6-alpha-D-mannan D-mannohydrolase activity" EXACT [EC:3.2.1.137] synonym: "exo-1,2-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.137] xref: EC:3.2.1.137 xref: MetaCyc:3.2.1.137-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0033942 name: 4-alpha-D-\{(1->4)-alpha-D-glucano}trehalose trehalohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan." [EC:3.2.1.141] synonym: "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" EXACT [EC:3.2.1.141] synonym: "malto-oligosyltrehalose trehalohydrolase activity" EXACT [EC:3.2.1.141] synonym: "maltooligosyl trehalose trehalohydrolase activity" EXACT [EC:3.2.1.141] xref: EC:3.2.1.141 xref: MetaCyc:3.2.1.141-RXN xref: Reactome:263435 "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase activity" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033943 name: galactan 1,3-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans." [EC:3.2.1.145] synonym: "galactan (1->3)-beta-D-galactosidase activity" EXACT [EC:3.2.1.145] xref: EC:3.2.1.145 xref: MetaCyc:3.2.1.145-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033944 name: beta-galactofuranosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose." [EC:3.2.1.146] synonym: "beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146] synonym: "beta-D-galactofuranoside hydrolase activity" EXACT [EC:3.2.1.146] synonym: "exo-beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146] synonym: "exo-beta-galactofuranosidase activity" EXACT [EC:3.2.1.146] xref: EC:3.2.1.146 xref: MetaCyc:3.2.1.146-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033945 name: oligoxyloglucan reducing-end-specific cellobiohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-1,4-linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted." [EC:3.2.1.150] synonym: "oligoxyloglucan reducing end-specific cellobiohydrolase activity" EXACT [EC:3.2.1.150] synonym: "oligoxyloglucan reducing-end cellobiohydrolase activity" EXACT [EC:3.2.1.150] xref: EC:3.2.1.150 xref: MetaCyc:3.2.1.150-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033946 name: xyloglucan-specific endo-beta-1,4-glucanase activity namespace: molecular_function def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.151] synonym: "1,4-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151] synonym: "[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151] synonym: "XEG" RELATED [EC:3.2.1.151] synonym: "XH" RELATED [EC:3.2.1.151] synonym: "xyloglucan endo-beta-1,4-glucanase activity" EXACT [EC:3.2.1.151] synonym: "xyloglucanase activity" EXACT [EC:3.2.1.151] synonym: "xyloglucanendohydrolase activity" EXACT [EC:3.2.1.151] xref: EC:3.2.1.151 xref: MetaCyc:3.2.1.151-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033947 name: mannosylglycoprotein endo-beta-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences." [EC:3.2.1.152] synonym: "endo-beta-mannosidase activity" EXACT [EC:3.2.1.152] xref: EC:3.2.1.152 xref: MetaCyc:3.2.1.152-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0033948 name: fructan beta-(2,1)-fructosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing 2,1-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.153] synonym: "1-FEH II" RELATED [EC:3.2.1.153] synonym: "1-FEH w1" RELATED [EC:3.2.1.153] synonym: "1-FEH w2" RELATED [EC:3.2.1.153] synonym: "1-fructan exohydrolase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2,1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2-1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2-1)-linkage-specific fructan-beta-fructosidase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2-1)fructan exohydrolase activity" EXACT [EC:3.2.1.153] xref: EC:3.2.1.153 xref: MetaCyc:3.2.1.153-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033949 name: fructan beta-(2,6)-fructosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.154] synonym: "6-FEH" RELATED [EC:3.2.1.154] synonym: "beta-(2,6)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.154] synonym: "beta-(2-6)-fructan exohydrolase activity" EXACT [EC:3.2.1.154] xref: EC:3.2.1.154 xref: MetaCyc:3.2.1.154-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033950 name: xyloglucan-specific exo-beta-1,4-glucanase activity namespace: molecular_function def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.155] synonym: "[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity" EXACT [EC:3.2.1.155] synonym: "Cel74A" RELATED [EC:3.2.1.155] xref: EC:3.2.1.155 xref: MetaCyc:3.2.1.155-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033951 name: oligosaccharide reducing-end xylanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides." [EC:3.2.1.156] synonym: "beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity" EXACT [EC:3.2.1.156] synonym: "reducing end xylose-releasing exo-oligoxylanase activity" EXACT [EC:3.2.1.156] synonym: "Rex" RELATED [EC:3.2.1.156] xref: EC:3.2.1.156 xref: MetaCyc:3.2.1.156-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033952 name: iota-carrageenase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans." [EC:3.2.1.157] synonym: "iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity" EXACT [EC:3.2.1.157] xref: EC:3.2.1.157 xref: MetaCyc:3.2.1.157-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033953 name: alpha-agarase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product." [EC:3.2.1.158] synonym: "agarase A33 activity" NARROW [EC:3.2.1.158] synonym: "agarase activity" BROAD [EC:3.2.1.158] synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.158] xref: EC:3.2.1.158 xref: MetaCyc:3.2.1.158-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033954 name: alpha-neoagaro-oligosaccharide hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose." [EC:3.2.1.159] synonym: "alpha-NAOS hydrolase activity" EXACT [EC:3.2.1.159] synonym: "alpha-neoagaro-oligosaccharide 3-glycohydrolase activity" EXACT [EC:3.2.1.159] synonym: "alpha-neoagarooligosaccharide hydrolase activity" EXACT [EC:3.2.1.159] xref: EC:3.2.1.159 xref: MetaCyc:3.2.1.159-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033955 name: mitochondrial DNA inheritance namespace: biological_process def: "The process in which copies of the mitochondrial genome are segregated or distributed into daughter mitochondria upon mitochondrial fission." [GOC:mah] synonym: "mitochondrial chromosome segregation" RELATED [] synonym: "mitochondrial DNA segregation" RELATED [] is_a: GO:0000002 ! mitochondrial genome maintenance relationship: part_of GO:0000001 ! mitochondrion inheritance [Term] id: GO:0033956 name: beta-apiosyl-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose." [EC:3.2.1.161] synonym: "7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity" EXACT [EC:3.2.1.161] synonym: "furcatin hydrolase activity" EXACT [EC:3.2.1.161] synonym: "isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity" EXACT [EC:3.2.1.161] synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity" EXACT [EC:3.2.1.161] xref: EC:3.2.1.161 xref: MetaCyc:3.2.1.161-RXN xref: MetaCyc:RXN-9156 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0033957 name: lambda-carrageenase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S." [EC:3.2.1.162] synonym: "endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity" EXACT [EC:3.2.1.162] xref: EC:3.2.1.162 xref: MetaCyc:3.2.1.162-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033958 name: DNA-deoxyinosine glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine." [EC:3.2.2.15] synonym: "deoxyribonucleic acid glycosylase activity" EXACT [EC:3.2.2.15] synonym: "DNA(hypoxanthine) glycohydrolase activity" EXACT [EC:3.2.2.15] synonym: "DNA-deoxyinosine deoxyribohydrolase activity" EXACT [EC:3.2.2.15] synonym: "DNA-deoxyinosine glycosidase activity" EXACT [EC:3.2.2.15] synonym: "hypoxanthine-DNA glycosylase activity" EXACT [EC:3.2.2.15] xref: EC:3.2.2.15 xref: MetaCyc:3.2.2.15-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0033959 name: deoxyribodipyrimidine endonucleosidase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue." [EC:3.2.2.17] synonym: "deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity" EXACT [EC:3.2.2.17] synonym: "deoxyribonucleate pyrimidine dimer glycosidase activity" EXACT [EC:3.2.2.17] synonym: "endonuclease V activity" BROAD [EC:3.2.2.17] synonym: "PD-DNA glycosylase activity" EXACT [EC:3.2.2.17] synonym: "pyrimidine dimer DNA glycosylase activity" EXACT [EC:3.2.2.17] synonym: "pyrimidine dimer DNA-glycosylase activity" EXACT [EC:3.2.2.17] synonym: "T4-induced UV endonuclease activity" EXACT [EC:3.2.2.17] xref: EC:3.2.2.17 xref: MetaCyc:3.2.2.17-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0033960 name: N-methyl nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylxanthosine + H(2)O = 7-methylxanthine + H(+) + ribofuranose." [EC:3.2.2.25, RHEA:10883] synonym: "7-methylxanthosine nucleosidase activity" EXACT [EC:3.2.2.25] synonym: "7-methylxanthosine ribohydrolase activity" EXACT [EC:3.2.2.25] synonym: "methylpurine nucleosidase activity" EXACT [EC:3.2.2.25] synonym: "N-MeNase activity" EXACT [EC:3.2.2.25] synonym: "N-methyl nucleoside hydrolase activity" EXACT [EC:3.2.2.25] xref: EC:3.2.2.25 xref: KEGG:R07918 xref: MetaCyc:RXN-7597 xref: RHEA:10883 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0033961 name: cis-stilbene-oxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "cis-epoxide hydrolase activity" EXACT [EC:3.3.2.9] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "mEH" RELATED [EC:3.3.2.9] synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9] xref: EC:3.3.2.9 xref: MetaCyc:3.3.2.9-RXN is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0033962 name: cytoplasmic mRNA processing body assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074] synonym: "P body assembly" EXACT [] synonym: "P body biogenesis" RELATED [] synonym: "P-body assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly [Term] id: GO:0033963 name: cholesterol-5,6-oxide hydrolase activity namespace: molecular_function def: "Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol." [EC:3.3.2.11] synonym: "5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity" EXACT [EC:3.3.2.11] synonym: "ChEH" RELATED [EC:3.3.2.11] synonym: "cholesterol-epoxide hydrolase activity" EXACT [EC:3.3.2.11] xref: EC:3.3.2.11 xref: MetaCyc:RXN-8650 xref: MetaCyc:RXN-8651 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0033964 name: glycosphingolipid deacylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives." [EC:3.5.1.69] synonym: "glycosphingolipid amidohydrolase activity" EXACT [EC:3.5.1.69] synonym: "glycosphingolipid ceramide deacylase activity" BROAD [EC:3.5.1.69] xref: EC:3.5.1.69 xref: MetaCyc:3.5.1.69-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033965 name: aculeacin-A deacylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain." [EC:3.5.1.70] synonym: "aculeacin A acylase activity" EXACT [EC:3.5.1.70] synonym: "aculeacin-A amidohydrolase activity" EXACT [EC:3.5.1.70] xref: EC:3.5.1.70 xref: MetaCyc:3.5.1.70-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033966 name: N-substituted formamide deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine." [EC:3.5.1.91] synonym: "N-benzylformamide amidohydrolase activity" EXACT [EC:3.5.1.91] synonym: "NfdA" RELATED [EC:3.5.1.91] xref: MetaCyc:3.5.1.91-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033967 name: box C/D snoRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving box C/D type small nucleolar RNA." [GOC:mah] is_a: GO:0016074 ! snoRNA metabolic process [Term] id: GO:0033968 name: glutaryl-7-aminocephalosporanic-acid acylase activity namespace: molecular_function def: "Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate." [EC:3.5.1.93] synonym: "(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity" EXACT [EC:3.5.1.93] synonym: "7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity" EXACT [EC:3.5.1.93] synonym: "CA" RELATED [EC:3.5.1.93] synonym: "cephalosporin acylase activity" EXACT [EC:3.5.1.93] synonym: "cephalosporin C acylase activity" EXACT [EC:3.5.1.93] synonym: "GA" RELATED [EC:3.5.1.93] synonym: "GCA" RELATED [EC:3.5.1.93] synonym: "GL-7-ACA acylase activity" EXACT [EC:3.5.1.93] synonym: "glutaryl-7-ACA acylase activity" EXACT [EC:3.5.1.93] synonym: "glutaryl-7-aminocephalosporanic acid acylase activity" EXACT [EC:3.5.1.93] xref: EC:3.5.1.93 xref: MetaCyc:3.5.1.93-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033969 name: gamma-glutamyl-gamma-aminobutyrate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H(2)O = 4-aminobutanoate + L-glutamate." [EC:3.5.1.94, RHEA:19740] synonym: "4-(glutamylamino)butanoate amidohydrolase activity" EXACT [EC:3.5.1.94] synonym: "gamma-glutamyl-GABA hydrolase activity" EXACT [EC:3.5.1.94] synonym: "PuuD" RELATED [EC:3.5.1.94] synonym: "YcjL" RELATED [EC:3.5.1.94] xref: EC:3.5.1.94 xref: KEGG:R07419 xref: MetaCyc:RXN0-3942 xref: RHEA:19740 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033970 name: N-malonylurea hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H(2)O = H(+) + malonate + urea." [EC:3.5.1.95, RHEA:17364] synonym: "3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity" EXACT [EC:3.5.1.95] synonym: "ureidomalonase activity" EXACT [EC:3.5.1.95] xref: EC:3.5.1.95 xref: KEGG:R07629 xref: MetaCyc:3.5.1.95-RXN xref: RHEA:17364 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033971 name: hydroxyisourate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)." [EC:3.5.2.17, RHEA:23739] synonym: "5-hydroxyisourate amidohydrolase activity" EXACT [EC:3.5.2.17] synonym: "5-hydroxyisourate hydrolase activity" EXACT [EC:3.5.2.17] synonym: "HIUHase activity" EXACT [EC:3.5.2.17] xref: EC:3.5.2.17 xref: KEGG:R06601 xref: MetaCyc:3.5.2.17-RXN xref: RHEA:23739 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0033972 name: proclavaminate amidinohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: amidinoproclavaminate + H(2)O = proclavaminate + urea." [EC:3.5.3.22, RHEA:17004] synonym: "PAH" RELATED [EC:3.5.3.22] synonym: "proclavaminate amidino hydrolase activity" EXACT [EC:3.5.3.22] synonym: "proclavaminic acid amidino hydrolase activity" EXACT [EC:3.5.3.22] xref: EC:3.5.3.22 xref: KEGG:R05357 xref: MetaCyc:3.5.3.22-RXN xref: RHEA:17004 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0033973 name: dCTP deaminase (dUMP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + 2 H(2)O = diphosphate + dUMP + H(+) + NH(4)(+)." [EC:3.5.4.30, RHEA:19208] synonym: "dCTP aminohydrolase (dUMP-forming) activity" EXACT [EC:3.5.4.30] xref: EC:3.5.4.30 xref: KEGG:R07307 xref: MetaCyc:3.5.4.30-RXN xref: RHEA:19208 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0033974 name: nucleoside phosphoacylhydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of mixed phospho-anhydride bonds." [EC:3.6.1.24] synonym: "nucleoside-5'-phosphoacylate acylhydrolase activity" EXACT [EC:3.6.1.24] xref: EC:3.6.1.24 xref: MetaCyc:3.6.1.24-RXN is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0033975 name: (R)-2-haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.9] synonym: "(R)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.9] synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.9] synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.9] synonym: "D-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.9] synonym: "D-DEX" RELATED [EC:3.8.1.9] xref: EC:3.8.1.9 xref: MetaCyc:3.8.1.9-RXN is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0033976 name: 2-haloacid dehalogenase (configuration-inverting) activity namespace: molecular_function def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.10] synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.10] synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.10] synonym: "DL-2-haloacid dehalogenase (inversion of configuration) activity" EXACT [EC:3.8.1.10] synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.10] synonym: "DL-2-haloacid halidohydrolase (inversion of configuration) activity" EXACT [EC:3.8.1.10] synonym: "DL-DEXi" RELATED [EC:3.8.1.10] xref: EC:3.8.1.10 xref: MetaCyc:3.8.1.10-RXN is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0033977 name: 2-haloacid dehalogenase (configuration-retaining) activity namespace: molecular_function def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.11] synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.11] synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.11] synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.11] synonym: "DL-DEXr" RELATED [EC:3.8.1.11] xref: EC:3.8.1.11 xref: MetaCyc:3.8.1.11-RXN is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0033978 name: phosphonopyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphonopyruvate + H(2)O = phosphate + pyruvate." [EC:3.11.1.3, RHEA:16676] synonym: "PPH" RELATED [EC:3.11.1.3] xref: EC:3.11.1.3 xref: KEGG:R08200 xref: MetaCyc:3.11.1.3-RXN xref: RHEA:16676 is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds [Term] id: GO:0033979 name: box H/ACA snoRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving box H/ACA type small nucleolar RNA." [GOC:mah] is_a: GO:0016074 ! snoRNA metabolic process [Term] id: GO:0033980 name: phosphonopyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphonopyruvate + 2 H(+) = CO(2) + phosphonoacetaldehyde." [EC:4.1.1.82, RHEA:20771] synonym: "3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity" EXACT [EC:4.1.1.82] synonym: "3-phosphonopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.82] xref: EC:4.1.1.82 xref: KEGG:R04053 xref: MetaCyc:4.1.1.82-RXN xref: RHEA:20771 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0033981 name: D-dopachrome decarboxylase activity namespace: molecular_function alt_id: GO:0030928 def: "Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2)." [EC:4.1.1.84, RHEA:18444] synonym: "D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity" EXACT [EC:4.1.1.84] synonym: "D-dopachrome carboxy-lyase activity" EXACT [EC:4.1.1.84] synonym: "D-dopachrome tautomerase activity" EXACT [EC:4.1.1.84] synonym: "D-tautomerase activity" EXACT [EC:4.1.1.84] synonym: "dopachrome conversion activity" BROAD [] synonym: "dopachrome decarboxylase activity" EXACT [] synonym: "phenylpyruvate tautomerase II activity" EXACT [EC:4.1.1.84] xref: EC:4.1.1.84 xref: KEGG:R07313 xref: MetaCyc:4.1.1.84-RXN xref: RHEA:18444 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0033982 name: 3-dehydro-L-gulonate-6-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H(+) = L-xylulose 5-phosphate + CO(2)." [EC:4.1.1.85, RHEA:14356] synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity" EXACT [EC:4.1.1.85] synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.85] synonym: "3-keto-L-gulonate 6-phosphate decarboxylase activity" EXACT [EC:4.1.1.85] synonym: "KGPDC" RELATED [EC:4.1.1.85] synonym: "SgaH" RELATED [EC:4.1.1.85] synonym: "SgbH" RELATED [EC:4.1.1.85] synonym: "UlaD" RELATED [EC:4.1.1.85] xref: EC:4.1.1.85 xref: KEGG:R07125 xref: MetaCyc:RXN0-705 xref: RHEA:14356 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0033983 name: diaminobutyrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,4-diaminobutyrate + H(+) = 1,3-diaminopropane + CO(2)." [EC:4.1.1.86, RHEA:15692] synonym: "DABA DC" RELATED [EC:4.1.1.86] synonym: "L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity" EXACT [EC:4.1.1.86] synonym: "L-2,4-diaminobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.86] synonym: "L-2,4-diaminobutyrate decarboxylase activity" EXACT [EC:4.1.1.86] xref: EC:4.1.1.86 xref: KEGG:R07650 xref: MetaCyc:4.1.1.86-RXN xref: RHEA:15692 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0033984 name: indole-3-glycerol-phosphate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate." [EC:4.1.2.8] synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity" EXACT [EC:4.1.2.8] synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8] synonym: "BX1" RELATED [EC:4.1.2.8] synonym: "IGL" RELATED [EC:4.1.2.8] synonym: "indole glycerol phosphate hydrolase activity" EXACT [EC:4.1.2.8] synonym: "indole synthase activity" EXACT [EC:4.1.2.8] synonym: "indole-3-glycerol phosphate lyase activity" EXACT [EC:4.1.2.8] synonym: "indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8] synonym: "indoleglycerolphosphate aldolase activity" EXACT [EC:4.1.2.8] synonym: "tryptophan synthase alpha activity" NARROW [EC:4.1.2.8] synonym: "tryptophan synthase alpha subunit activity" NARROW [EC:4.1.2.8] synonym: "TSA" RELATED [EC:4.1.2.8] xref: EC:4.1.2.8 xref: KEGG:R02340 xref: MetaCyc:4.1.2.8-RXN xref: MetaCyc:RXN0-2381 xref: RHEA:14084 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0033985 name: acidocalcisome lumen namespace: cellular_component def: "The volume enclosed by the membranes of an acidocalcisome." [GOC:mah] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0020022 ! acidocalcisome [Term] id: GO:0033986 name: response to methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:sl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0033987 name: 2-hydroxyisoflavanone dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O." [EC:4.2.1.105] synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity" EXACT [EC:4.2.1.105] synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase activity" EXACT [EC:4.2.1.105] xref: EC:4.2.1.105 xref: MetaCyc:RXN-3284 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033988 name: bile-acid 7alpha-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(2)O." [EC:4.2.1.106, RHEA:10439] synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity" EXACT [EC:4.2.1.106] synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity" EXACT [EC:4.2.1.106] synonym: "BA7 alpha dehydratase activity" EXACT [EC:4.2.1.106] xref: EC:4.2.1.106 xref: KEGG:R07318 xref: MetaCyc:4.2.1.106-RXN xref: RHEA:10439 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033989 name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107] synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity" EXACT [EC:4.2.1.107] synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.107] synonym: "46 kDa hydratase 2 activity" EXACT [EC:4.2.1.107] synonym: "D-3-hydroxyacyl-CoA dehydratase activity" BROAD [EC:4.2.1.107] xref: EC:4.2.1.107 xref: MetaCyc:4.2.1.107-RXN xref: Reactome:261000 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033990 name: ectoine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H(2)O." [EC:4.2.1.108, RHEA:17284] synonym: "4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108] synonym: "EctC" RELATED [EC:4.2.1.108] synonym: "L-ectoine synthase activity" EXACT [EC:4.2.1.108] synonym: "N-acetyldiaminobutanoate dehydratase activity" EXACT [EC:4.2.1.108] synonym: "N-acetyldiaminobutyrate dehydratase activity" EXACT [EC:4.2.1.108] synonym: "N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108] xref: EC:4.2.1.108 xref: KEGG:R06979 xref: MetaCyc:R103-RXN xref: RHEA:17284 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033991 name: aldos-2-ulose dehydratase activity namespace: molecular_function def: "Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one." [EC:4.2.1.110] synonym: "1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity" EXACT [EC:4.2.1.110] synonym: "1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity" EXACT [EC:4.2.1.110] synonym: "AUDH" RELATED [EC:4.2.1.110] synonym: "pyranosone dehydratase activity" EXACT [EC:4.2.1.110] xref: EC:4.2.1.110 xref: MetaCyc:4.2.1.110-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033992 name: 1,5-anhydro-D-fructose dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O." [EC:4.2.1.111] synonym: "1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose 4-dehydratase activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose hydro-lyase activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose hydrolyase activity" EXACT [EC:4.2.1.111] synonym: "AF dehydratase activity" EXACT [EC:4.2.1.111] synonym: "AFDH" RELATED [EC:4.2.1.111] xref: EC:4.2.1.111 xref: MetaCyc:4.2.1.111-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033993 name: response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0033994 name: glucuronan lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides." [EC:4.2.2.14] synonym: "(1,4)-beta-D-glucuronan lyase activity" EXACT [EC:4.2.2.14] xref: EC:4.2.2.14 xref: MetaCyc:4.2.2.14-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033995 name: anhydrosialidase activity namespace: molecular_function def: "Catalysis of the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate." [EC:4.2.2.15] synonym: "anhydroneuraminidase activity" EXACT [EC:4.2.2.15] synonym: "glycoconjugate sialyl-lyase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15] synonym: "sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15] synonym: "sialidase L activity" EXACT [EC:4.2.2.15] xref: EC:4.2.2.15 xref: MetaCyc:4.2.2.15-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033996 name: levan fructotransferase (DFA-IV-forming) activity namespace: molecular_function def: "Catalysis of the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.16] synonym: "2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity" EXACT [EC:4.2.2.16] synonym: "2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity" EXACT [EC:4.2.2.16] synonym: "levan fructotransferase activity" EXACT [EC:4.2.2.16] xref: EC:4.2.2.16 xref: MetaCyc:4.2.2.16-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033997 name: inulin fructotransferase (DFA-I-forming) activity namespace: molecular_function def: "Catalysis of the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.17] synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity" EXACT [EC:4.2.2.17] synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity" EXACT [EC:4.2.2.17] synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity" EXACT [EC:4.2.2.17] synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity" EXACT [EC:4.2.2.17] synonym: "inulin fructotransferase (DFA-I-producing) activity" EXACT [EC:4.2.2.17] xref: EC:4.2.2.17 xref: MetaCyc:4.2.2.17-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033998 name: inulin fructotransferase (DFA-III-forming) activity namespace: molecular_function def: "Catalysis of the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.18] synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] synonym: "inulase II activity" EXACT [EC:4.2.2.18] synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity" EXACT [EC:4.2.2.18] synonym: "inulin fructotransferase (depolymerizing) activity" EXACT [EC:4.2.2.18] synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] synonym: "inulin fructotransferase (DFA-III-producing) activity" EXACT [EC:4.2.2.18] synonym: "inulinase II activity" EXACT [EC:4.2.2.18] xref: EC:4.2.2.18 xref: MetaCyc:4.2.2.18-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033999 name: chondroitin B lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S)." [EC:4.2.2.19] synonym: "ChnB" RELATED [EC:4.2.2.19] synonym: "chonB" RELATED [EC:4.2.2.19] synonym: "chondroitinase B activity" EXACT [EC:4.2.2.19] xref: EC:4.2.2.19 xref: MetaCyc:4.2.2.19-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0034000 name: chondroitin-sulfate-ABC endolyase activity namespace: molecular_function def: "Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides." [EC:4.2.2.20] synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.20] synonym: "chondroitin sulfate ABC endoeliminase activity" EXACT [EC:4.2.2.20] synonym: "chondroitin sulfate ABC endolyase activity" EXACT [EC:4.2.2.20] synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.20] synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.20] synonym: "chondroitinase activity" BROAD [EC:4.2.2.20] synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.20] synonym: "ChS ABC lyase I activity" EXACT [EC:4.2.2.20] xref: EC:4.2.2.20 xref: MetaCyc:4.2.2.20-RXN is_a: GO:0047486 ! chondroitin ABC lyase activity [Term] id: GO:0034001 name: chondroitin-sulfate-ABC exolyase activity namespace: molecular_function def: "Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments." [EC:4.2.2.21] synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.21] synonym: "chondroitin sulfate ABC exoeliminase activity" EXACT [EC:4.2.2.21] synonym: "chondroitin sulfate ABC exolyase activity" EXACT [EC:4.2.2.21] synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.21] synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.21] synonym: "chondroitinase activity" BROAD [EC:4.2.2.21] synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.21] synonym: "ChS ABC lyase II activity" EXACT [EC:4.2.2.21] xref: EC:4.2.2.21 xref: MetaCyc:4.2.2.21-RXN is_a: GO:0047486 ! chondroitin ABC lyase activity [Term] id: GO:0034002 name: (R)-limonene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate." [EC:4.2.3.20, RHEA:10943] synonym: "(+)-limonene synthase activity" EXACT [EC:4.2.3.20] synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity" EXACT [EC:4.2.3.20] synonym: "geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity" EXACT [EC:4.2.3.20] xref: EC:4.2.3.20 xref: KEGG:R06120 xref: MetaCyc:4.2.3.20-RXN xref: RHEA:10943 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0034003 name: vetispiradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene." [EC:4.2.3.21, RHEA:10343] synonym: "HVS" RELATED [EC:4.2.3.21] synonym: "pemnaspirodiene synthase activity" EXACT [EC:4.2.3.21] synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity" EXACT [EC:4.2.3.21] synonym: "vetispiradiene cyclase activity" EXACT [EC:4.2.3.21] synonym: "vetispiradiene-forming farnesyl pyrophosphate cyclase activity" EXACT [EC:4.2.3.21] xref: EC:4.2.3.21 xref: KEGG:R06523 xref: MetaCyc:RXN-4823 xref: RHEA:10343 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0034004 name: germacradienol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate." [EC:4.2.3.22] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity" EXACT [EC:4.2.3.22] xref: EC:4.2.3.22 xref: KEGG:R07647 xref: MetaCyc:RXN-8648 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034005 name: germacrene-A synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate." [EC:4.2.3.23, RHEA:12519] synonym: "(+)-(10R)-germacrene A synthase activity" EXACT [EC:4.2.3.23] synonym: "(+)-germacrene A synthase activity" EXACT [EC:4.2.3.23] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity" EXACT [EC:4.2.3.23] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity" EXACT [EC:4.2.3.23] synonym: "GAS" RELATED [EC:4.2.3.23] synonym: "germacrene A synthase activity" EXACT [EC:4.2.3.23] xref: EC:4.2.3.23 xref: KEGG:R07649 xref: MetaCyc:4.2.3.23-RXN xref: RHEA:12519 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0034006 name: amorpha-4,11-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate." [EC:4.2.3.24, RHEA:18328] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity" EXACT [EC:4.2.3.24] synonym: "amorphadiene synthase activity" EXACT [EC:4.2.3.24] xref: EC:4.2.3.24 xref: KEGG:R07630 xref: MetaCyc:4.2.3.24-RXN xref: MetaCyc:RXN-8046 xref: RHEA:18328 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0034007 name: S-linalool synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (S)-linalool + diphosphate." [EC:4.2.3.25, RHEA:24119] synonym: "3S-linalool synthase activity" EXACT [EC:4.2.3.25] synonym: "geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity" EXACT [EC:4.2.3.25] synonym: "LIS" RELATED [EC:4.2.3.25] synonym: "Lis" RELATED [EC:4.2.3.25] xref: EC:4.2.3.25 xref: KEGG:R07631 xref: MetaCyc:4.2.3.25-RXN xref: RHEA:24119 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034008 name: R-linalool synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (R)-linalool + diphosphate." [EC:4.2.3.26, RHEA:15812] synonym: "(-)-3R-linalool synthase activity" EXACT [EC:4.2.3.26] synonym: "(3R)-linalool synthase activity" EXACT [EC:4.2.3.26] synonym: "geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity" EXACT [EC:4.2.3.26] xref: EC:4.2.3.26 xref: KEGG:R07632 xref: MetaCyc:4.2.3.26-RXN xref: RHEA:15812 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034009 name: isoprene synthase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene." [EC:4.2.3.27, RHEA:13372] synonym: "dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity" EXACT [EC:4.2.3.27] synonym: "ISPC" RELATED [EC:4.2.3.27] synonym: "ISPS" RELATED [EC:4.2.3.27] xref: EC:4.2.3.27 xref: KEGG:R08199 xref: MetaCyc:4.2.3.27-RXN xref: RHEA:13372 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0034010 name: sulfolactate sulfo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite." [EC:4.4.1.24, RHEA:21431] synonym: "3-sulfolactate bisulfite-lyase (pyruvate-forming) activity" EXACT [EC:4.4.1.24] synonym: "3-sulfolactate bisulfite-lyase activity" EXACT [EC:4.4.1.24] synonym: "Suy" RELATED [EC:4.4.1.24] synonym: "SuyAB" RELATED [EC:4.4.1.24] xref: EC:4.4.1.24 xref: KEGG:R07633 xref: MetaCyc:4.4.1.24-RXN xref: RHEA:21431 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0034011 name: L-cysteate sulfo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteate + H(2)O = NH(4)(+) + pyruvate + sulfite." [EC:4.4.1.25, RHEA:13444] synonym: "CuyA" RELATED [EC:4.4.1.25] synonym: "L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity" EXACT [EC:4.4.1.25] synonym: "L-cysteate sulfo-lyase (deaminating) activity" EXACT [EC:4.4.1.25] xref: EC:4.4.1.25 xref: KEGG:R07634 xref: MetaCyc:4.4.1.25-RXN xref: RHEA:13444 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0034012 name: FAD-AMP lyase (cyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate." [EC:4.6.1.15] synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" EXACT [EC:4.6.1.15] synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" EXACT [EC:4.6.1.15] synonym: "FMN cyclase activity" EXACT [EC:4.6.1.15] xref: EC:4.6.1.15 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0034013 name: aliphatic aldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O." [EC:4.99.1.5] synonym: "aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity" EXACT [EC:4.99.1.5] synonym: "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.99.1.5] synonym: "OxdA" RELATED [EC:4.99.1.5] xref: EC:4.99.1.5 xref: MetaCyc:4.99.1.5-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0034014 name: response to triglyceride namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:sl] synonym: "response to triacylglyceride" EXACT [] synonym: "response to triacylglycerol" EXACT [] is_a: GO:0033993 ! response to lipid [Term] id: GO:0034015 name: L-ribulose-5-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate." [EC:5.1.3.22] synonym: "L-xylulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.22] synonym: "SgaU" RELATED [EC:5.1.3.22] synonym: "UlaE" RELATED [EC:5.1.3.22] xref: EC:5.1.3.22 xref: MetaCyc:LXULRU5P-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0034016 name: polyenoic fatty acid isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate." [EC:5.3.3.13, RHEA:14892] synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity" EXACT [EC:5.3.3.13] synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13] synonym: "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13] synonym: "eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity" EXACT [EC:5.3.3.13] synonym: "PFI" RELATED [EC:5.3.3.13] xref: EC:5.3.3.13 xref: KEGG:R06502 xref: MetaCyc:5.3.3.13-RXN xref: RHEA:14892 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0034017 name: trans-2-decenoyl-acyl-carrier-protein isomerase activity namespace: molecular_function alt_id: GO:0043832 def: "Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]." [EC:5.3.3.14, IMG:02508] synonym: "beta-hydroxydecanoyl thioester dehydrase activity" BROAD [EC:5.3.3.14] synonym: "decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity" EXACT [EC:5.3.3.14] synonym: "FabM" RELATED [EC:5.3.3.14] synonym: "trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity" EXACT [] synonym: "trans-2, cis-3 decenoyl-ACP isomerase activity" EXACT [] synonym: "trans-2,cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] synonym: "trans-2-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] xref: EC:5.3.3.14 xref: MetaCyc:5.3.3.14-RXN is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0034018 name: ascopyrone tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose." [EC:5.3.3.15] synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity" EXACT [EC:5.3.3.15] synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity" EXACT [EC:5.3.3.15] synonym: "APM tautomerase activity" EXACT [EC:5.3.3.15] synonym: "APTM" RELATED [EC:5.3.3.15] synonym: "ascopyrone intramolecular oxidoreductase activity" EXACT [EC:5.3.3.15] synonym: "ascopyrone isomerase activity" EXACT [EC:5.3.3.15] synonym: "ascopyrone P tautomerase activity" EXACT [EC:5.3.3.15] xref: EC:5.3.3.15 xref: MetaCyc:5.3.3.15-RXN is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0034019 name: capsanthin/capsorubin synthase activity namespace: molecular_function def: "Catalysis of the reactions: violaxanthin = capsorubin, and antheraxanthin = capsanthin." [EC:5.3.99.8] synonym: "capsanthin-capsorubin synthase activity" EXACT [EC:5.3.99.8] synonym: "CCS" RELATED [EC:5.3.99.8] synonym: "ketoxanthophyll synthase activity" EXACT [EC:5.3.99.8] synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" EXACT [EC:5.3.99.8] xref: EC:5.3.99.8 xref: MetaCyc:RXN-7946 xref: MetaCyc:RXN-7947 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0034020 name: neoxanthin synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin." [EC:5.3.99.9, RHEA:10131] synonym: "NSY" RELATED [EC:5.3.99.9] synonym: "violaxanthin-neoxanthin isomerase (epoxide-opening) activity" EXACT [EC:5.3.99.9] xref: EC:5.3.99.9 xref: KEGG:R06948 xref: MetaCyc:RXN1F-155 xref: RHEA:10131 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0034021 name: response to silicon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:sl] synonym: "response to silica" EXACT [] synonym: "response to silox" EXACT [] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0034022 name: 3-(hydroxyamino)phenol mutase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone." [EC:5.4.4.3, RHEA:20580] synonym: "3-(hydroxyamino)phenol hydroxymutase activity" EXACT [EC:5.4.4.3] synonym: "3-hydroxylaminophenol mutase activity" EXACT [EC:5.4.4.3] synonym: "3HAP mutase activity" EXACT [EC:5.4.4.3] xref: EC:5.4.4.3 xref: KEGG:R06988 xref: MetaCyc:5.4.4.3-RXN xref: RHEA:20580 xref: UM-BBD_enzymeID:e0953 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0034023 name: 5-(carboxyamino)imidazole ribonucleotide mutase activity namespace: molecular_function def: "Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [EC:5.4.99.18] synonym: "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity" EXACT [EC:5.4.99.18] synonym: "class I PurE" RELATED [EC:5.4.99.18] synonym: "N5-CAIR mutase activity" EXACT [EC:5.4.99.18] synonym: "N5-carboxyaminoimidazole ribonucleotide mutase activity" EXACT [EC:5.4.99.18] synonym: "PurE" RELATED [EC:5.4.99.18] xref: EC:5.4.99.18 xref: MetaCyc:5.4.99.18-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0034024 name: glutamate-putrescine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H(+) + phosphate." [EC:6.3.1.11, RHEA:13636] synonym: "gamma-glutamylputrescine synthetase activity" EXACT [EC:6.3.1.11] synonym: "L-glutamate:putrescine ligase (ADP-forming) activity" EXACT [EC:6.3.1.11] synonym: "YcjK" RELATED [EC:6.3.1.11] xref: EC:6.3.1.11 xref: KEGG:R07414 xref: MetaCyc:RXN0-3901 xref: RHEA:13636 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0034025 name: D-aspartate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate." [EC:6.3.1.12] synonym: "aslfm" RELATED [EC:6.3.1.12] synonym: "D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity" EXACT [EC:6.3.1.12] synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12] synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" EXACT [EC:6.3.1.12] xref: EC:6.3.1.12 xref: MetaCyc:6.3.1.12-RXN is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0034026 name: L-amino-acid alpha-ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid." [EC:6.3.2.28] synonym: "bacilysin synthetase activity" EXACT [EC:6.3.2.28] synonym: "L-amino acid alpha-ligase activity" EXACT [EC:6.3.2.28] synonym: "L-amino acid ligase activity" EXACT [EC:6.3.2.28] synonym: "YwfE" RELATED [EC:6.3.2.28] xref: EC:6.3.2.28 xref: MetaCyc:6.3.2.28-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0034027 name: (carboxyethyl)arginine beta-lactam-synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H(+)." [EC:6.3.3.4, RHEA:23623] synonym: "beta-lactam synthetase activity" EXACT [EC:6.3.3.4] synonym: "L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4] synonym: "L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4] xref: EC:6.3.3.4 xref: KEGG:R05467 xref: MetaCyc:6.3.3.4-RXN xref: RHEA:23623 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0034028 name: 5-(carboxyamino)imidazole ribonucleotide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate." [EC:6.3.4.18, RHEA:19320] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.18] synonym: "N5-CAIR synthetase activity" EXACT [EC:6.3.4.18] synonym: "N5-carboxyaminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.4.18] synonym: "PurK" RELATED [EC:6.3.4.18] xref: EC:6.3.4.18 xref: KEGG:R07404 xref: MetaCyc:RXN0-742 xref: RHEA:19320 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0034029 name: 2-oxoglutarate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H(+) + oxalosuccinate + phosphate." [EC:6.4.1.7, RHEA:20428] synonym: "carboxylating factor for ICDH" RELATED [EC:6.4.1.7] synonym: "CFI" RELATED [EC:6.4.1.7] synonym: "OGC" RELATED [EC:6.4.1.7] synonym: "oxalosuccinate synthetase activity" EXACT [EC:6.4.1.7] xref: EC:6.4.1.7 xref: KEGG:R08201 xref: MetaCyc:RXN-8457 xref: RHEA:20428 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0034030 name: ribonucleoside bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "ribonucleoside bisphosphate anabolism" EXACT [] synonym: "ribonucleoside bisphosphate biosynthesis" EXACT [] synonym: "ribonucleoside bisphosphate formation" EXACT [] synonym: "ribonucleoside bisphosphate synthesis" EXACT [] is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process [Term] id: GO:0034031 name: ribonucleoside bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "ribonucleoside bisphosphate breakdown" EXACT [] synonym: "ribonucleoside bisphosphate catabolism" EXACT [] synonym: "ribonucleoside bisphosphate degradation" EXACT [] is_a: GO:0033869 ! nucleoside bisphosphate catabolic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process [Term] id: GO:0034032 name: purine nucleoside bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "purine nucleoside bisphosphate metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0033865 ! nucleoside bisphosphate metabolic process [Term] id: GO:0034033 name: purine nucleoside bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "purine nucleoside bisphosphate anabolism" EXACT [] synonym: "purine nucleoside bisphosphate biosynthesis" EXACT [] synonym: "purine nucleoside bisphosphate formation" EXACT [] synonym: "purine nucleoside bisphosphate synthesis" EXACT [] is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process [Term] id: GO:0034034 name: purine nucleoside bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "purine nucleoside bisphosphate breakdown" EXACT [] synonym: "purine nucleoside bisphosphate catabolism" EXACT [] synonym: "purine nucleoside bisphosphate degradation" EXACT [] is_a: GO:0033869 ! nucleoside bisphosphate catabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process [Term] id: GO:0034035 name: purine ribonucleoside bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "purine ribonucleoside bisphosphate metabolism" EXACT [] is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process [Term] id: GO:0034036 name: purine ribonucleoside bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "purine ribonucleoside bisphosphate anabolism" EXACT [] synonym: "purine ribonucleoside bisphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside bisphosphate formation" EXACT [] synonym: "purine ribonucleoside bisphosphate synthesis" EXACT [] is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process [Term] id: GO:0034037 name: purine ribonucleoside bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "purine ribonucleoside bisphosphate breakdown" EXACT [] synonym: "purine ribonucleoside bisphosphate catabolism" EXACT [] synonym: "purine ribonucleoside bisphosphate degradation" EXACT [] is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process [Term] id: GO:0034038 name: deoxyhypusine synthase activity namespace: molecular_function def: "Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [EC:2.5.1.46, GOC:pde, MetaCyc:2.5.1.46-RXN] comment: Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase ; GO:0050983'. synonym: "eIF-5A-deoxyhypusine synthase activity" EXACT [EC:2.5.1.46] synonym: "eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46] synonym: "spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46] xref: EC:2.5.1.46 xref: MetaCyc:2.5.1.46-RXN xref: Reactome:210313 "deoxyhypusine synthase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0034039 name: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar." [GOC:mah, PMID:17641464] synonym: "8-oxoG DNA N-glycosylase activity" EXACT [] is_a: GO:0008534 ! oxidized purine base lesion DNA N-glycosylase activity [Term] id: GO:0034040 name: lipid-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)." [GOC:BHF, GOC:rl] is_a: GO:0005319 ! lipid transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0034041 name: sterol-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)." [GOC:BHF, GOC:rl] is_a: GO:0015248 ! sterol transporter activity is_a: GO:0034040 ! lipid-transporting ATPase activity [Term] id: GO:0034042 name: 5-formyluracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] synonym: "5-foU DNA N-glycosylase activity" EXACT [] is_a: GO:0000703 ! oxidized pyrimidine base lesion DNA N-glycosylase activity [Term] id: GO:0034043 name: 5-hydroxymethyluracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] synonym: "5-hmU DNA N-glycosylase activity" EXACT [] is_a: GO:0000703 ! oxidized pyrimidine base lesion DNA N-glycosylase activity [Term] id: GO:0034044 name: exomer complex namespace: cellular_component def: "A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues." [PMID:16498409, PMID:17000877] is_a: GO:0043234 ! protein complex is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle [Term] id: GO:0034045 name: pre-autophagosomal structure membrane namespace: cellular_component def: "A cellular membrane associated with the pre-autophagosomal structure." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324] synonym: "isolation membrane" RELATED [] synonym: "PAS membrane" EXACT [] synonym: "phagophore" RELATED [PMID:20811355] is_a: GO:0016020 ! membrane is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000407 ! pre-autophagosomal structure [Term] id: GO:0034046 name: poly(G) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule." [GOC:mah] synonym: "poly(G) binding" BROAD [] synonym: "poly(rG) binding" EXACT [GOC:mah] is_a: GO:0070717 ! poly-purine tract binding [Term] id: GO:0034047 name: regulation of protein phosphatase type 2A activity namespace: biological_process def: "Any process that modulates the activity of the enzyme protein phosphatase type 2A." [GOC:mah] is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity [Term] id: GO:0034048 name: negative regulation of protein phosphatase type 2A activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme protein phosphatase type 2A." [GOC:mah] subset: gosubset_prok synonym: "down regulation of protein phosphatase type 2A activity" EXACT [] synonym: "down-regulation of protein phosphatase type 2A activity" EXACT [] synonym: "downregulation of protein phosphatase type 2A activity" EXACT [] synonym: "inhibition of protein phosphatase type 2A activity" NARROW [] is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity is_a: GO:0034047 ! regulation of protein phosphatase type 2A activity [Term] id: GO:0034049 name: positive regulation of protein phosphatase type 2A activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme protein phosphatase type 2A." [GOC:mah] subset: gosubset_prok synonym: "activation of protein phosphatase type 2A activity" NARROW [] synonym: "stimulation of protein phosphatase type 2A activity" NARROW [] synonym: "up regulation of protein phosphatase type 2A activity" EXACT [] synonym: "up-regulation of protein phosphatase type 2A activity" EXACT [] synonym: "upregulation of protein phosphatase type 2A activity" EXACT [] is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity is_a: GO:0034047 ! regulation of protein phosphatase type 2A activity [Term] id: GO:0034050 name: host programmed cell death induced by symbiont namespace: biological_process def: "Cell death in a host resulting from activation of host endogenous cellular processes after direct or indirect interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). An example of direct interaction is contact with penetrating hyphae of a fungus; an example of indirect interaction is encountering symbiont-secreted molecules." [GOC:pamgo_curators] comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'induction by symbiont of host programmed cell death ; GO:0052044'. is_a: GO:0012501 ! programmed cell death [Term] id: GO:0034051 name: negative regulation of plant-type hypersensitive response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators] synonym: "down regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "down-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "downregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "inhibition of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "negative regulation of HR" EXACT [GOC:pamgo_curators] synonym: "negative regulation of HR-PCD" EXACT [GOC:pamgo_curators] synonym: "negative regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators] is_a: GO:0010363 ! regulation of plant-type hypersensitive response is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0045824 ! negative regulation of innate immune response relationship: negatively_regulates GO:0009626 ! plant-type hypersensitive response [Term] id: GO:0034052 name: positive regulation of plant-type hypersensitive response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators] synonym: "activation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "positive regulation of HR" EXACT [GOC:pamgo_curators] synonym: "positive regulation of HR-PCD" RELATED [GOC:pamgo_curators] synonym: "positive regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "stimulation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "up regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "up-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "upregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] is_a: GO:0010363 ! regulation of plant-type hypersensitive response is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0045089 ! positive regulation of innate immune response relationship: positively_regulates GO:0009626 ! plant-type hypersensitive response [Term] id: GO:0034053 name: modulation by symbiont of host defense-related programmed cell death namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'plant-type hypersensitive response ; GO:0009626'. synonym: "modulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] synonym: "modulation by symbiont of host HR" NARROW [GOC:pamgo_curators] synonym: "modulation by symbiont of host hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "modulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] synonym: "modulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052040 ! modulation by symbiont of host programmed cell death [Term] id: GO:0034054 name: negative regulation by symbiont of host defense-related programmed cell death namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of plant-type hypersensitive response ; GO:0034051'. synonym: "down regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "down-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "downregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "inhibition by symbiont of host defense-related PCD" NARROW [GOC:pamgo_curators] synonym: "inhibition by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] synonym: "inhibition of host defense-related PCD" NARROW [GOC:pamgo_curators] synonym: "inhibition of HR" NARROW [GOC:pamgo_curators] synonym: "inhibition of hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "negative regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] synonym: "negative regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] synonym: "negative regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "suppression by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] synonym: "suppression of HR" NARROW [GOC:pamgo_curators] is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death [Term] id: GO:0034055 name: positive regulation by symbiont of host defense-related programmed cell death namespace: biological_process def: "Any process in which an organism activates or increases the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of plant-type hypersensitive response ; GO:0034052'. synonym: "activation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] synonym: "activation of HR" NARROW [GOC:pamgo_curators] synonym: "activation of hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "enhancement by symbiont of host defense-related PCDprogrammed cell death" NARROW [GOC:pamgo_curators] synonym: "positive regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] synonym: "positive regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] synonym: "positive regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "stimulation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] synonym: "up regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "up-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "upregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death is_a: GO:0052509 ! positive regulation by symbiont of host defense response [Term] id: GO:0034056 name: estrogen response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "ERE binding" EXACT [] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0034057 name: RNA strand-exchange activity namespace: molecular_function def: "Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity." [GOC:mcc, PMID:9769100] is_a: GO:0003725 ! double-stranded RNA binding is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0034058 name: endosomal vesicle fusion namespace: biological_process def: "The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733] synonym: "endosome vesicle fusion" EXACT [] is_a: GO:0006906 ! vesicle fusion [Term] id: GO:0034059 name: response to anoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv] comment: Note that this term should not be confused with 'response to hypoxia ; GO:0001666'. synonym: "response to anoxic stress" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0034060 name: cyanelle stroma namespace: cellular_component def: "The space enclosed by the double membrane of a cyanelle." [GOC:rph] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0034061 name: DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer." [EC:2.7.7.7, GOC:mah] subset: gosubset_prok synonym: "deoxynucleate polymerase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid polymerase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase activity" EXACT [EC:2.7.7.7] is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0034062 name: RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [EC:2.7.7.6, GOC:mah] subset: gosubset_prok synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleate polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6] synonym: "ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic acid transcriptase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic transcriptase activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "RNA transcriptase activity" EXACT [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0034063 name: stress granule assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] synonym: "SG assembly" EXACT [PMID:19825938] is_a: GO:0022618 ! ribonucleoprotein complex assembly [Term] id: GO:0034064 name: Tor2-Mei2-Ste11 complex namespace: cellular_component def: "A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast." [GOC:vw, PMID:17046992] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0034065 name: replication fork processing at rDNA locus namespace: biological_process def: "The process in which a DNA replication fork that has stalled at the rDNA replication fork barrier (RFB) is repaired and replication is restarted." [GOC:vw] synonym: "recovery from replication fork arrest at rDNA locus" EXACT [] synonym: "recovery from replication fork stalling at rDNA locus" EXACT [] synonym: "replication fork processing at ribosomal DNA locus" EXACT [] is_a: GO:0031297 ! replication fork processing is_a: GO:0043007 ! maintenance of rDNA [Term] id: GO:0034066 name: Ric1p-Rgp1p complex namespace: cellular_component def: "A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi." [GOC:jh, GOC:mah, PMID:10990452] is_a: GO:0043234 ! protein complex is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0034067 name: protein localization in Golgi apparatus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah] synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah] synonym: "protein localization to Golgi apparatus" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0034068 name: aminoglycoside nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside." [GOC:cb] subset: gosubset_prok synonym: "aminoglycoside adenylyltransferase activity" NARROW [] synonym: "streptomycin adenylate synthetase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin adenyltransferase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin adenylylase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin-spectinomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0034069 name: aminoglycoside N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside." [GOC:cb] subset: gosubset_prok synonym: "kanamycin acetyltransferase activity" NARROW [] is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0034070 name: aminoglycoside 1-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring." [GOC:cb] is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity [Term] id: GO:0034071 name: aminoglycoside phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside." [GOC:cb, GOC:mah] subset: gosubset_prok synonym: "aminoglycoside kinase activity" EXACT [] xref: EC:2.7.1.- is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0034072 name: squalene cyclase activity namespace: molecular_function def: "Catalysis of the reaction: squalene = triterpene." [GOC:cb, PMID:18033581] is_a: GO:0009975 ! cyclase activity [Term] id: GO:0034073 name: tetrahymanol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: squalene = tetrahymanol." [CHEBI:9493, GOC:cb, PMID:18033581] is_a: GO:0034072 ! squalene cyclase activity [Term] id: GO:0034074 name: marneral synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581] xref: MetaCyc:RXN-9664 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0034075 name: arabidiol synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)." [GOC:cb, PMID:16774269, PMID:17474751] is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0034076 name: cucurbitadienol synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene = cucurbitadienol." [GOC:cb, PMID:18033581] is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0034077 name: butanediol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY] subset: gosubset_prok synonym: "butanediol metabolism" EXACT [] synonym: "butylene glycol metabolic process" EXACT [] synonym: "butylene glycol metabolism" EXACT [] is_a: GO:0034311 ! diol metabolic process [Term] id: GO:0034078 name: butanediol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL] subset: gosubset_prok synonym: "butanediol breakdown" EXACT [] synonym: "butanediol catabolism" EXACT [] synonym: "butanediol degradation" EXACT [] synonym: "butanediol utilization" RELATED [] synonym: "butylene glycol catabolic process" EXACT [] synonym: "butylene glycol catabolism" EXACT [] is_a: GO:0034077 ! butanediol metabolic process is_a: GO:0034313 ! diol catabolic process [Term] id: GO:0034079 name: butanediol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL] subset: gosubset_prok synonym: "butanediol anabolism" EXACT [] synonym: "butanediol biosynthesis" EXACT [] synonym: "butanediol formation" EXACT [] synonym: "butanediol synthesis" EXACT [] synonym: "butylene glycol biosynthesis" EXACT [] synonym: "butylene glycol biosynthetic process" EXACT [] xref: MetaCyc:P125-PWY is_a: GO:0034077 ! butanediol metabolic process is_a: GO:0034312 ! diol biosynthetic process [Term] id: GO:0034080 name: CenH3-containing nucleosome assembly at centromere namespace: biological_process def: "The formation of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A) to form centromeric chromatin; occurs outside the context of DNA replication." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403] synonym: "centromere specific nucleosome exchange" RELATED [GOC:mah] synonym: "centromere-specific histone exchange" EXACT [GOC:mah, GOC:vw] synonym: "centromere-specific nucleosome assembly" EXACT [GOC:vw] synonym: "centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:mah] synonym: "DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:mah] xref: Reactome:606279 "Deposition of New CENPA-containing Nucleosomes at the Centromere" is_a: GO:0006336 ! DNA replication-independent nucleosome assembly is_a: GO:0031055 ! chromatin remodeling at centromere is_a: GO:0043486 ! histone exchange [Term] id: GO:0034081 name: polyketide synthase complex namespace: cellular_component def: "A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones." [GOC:mah, PMID:12636085] synonym: "PKS" RELATED [] synonym: "PKS complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034082 name: type II polyketide synthase complex namespace: cellular_component def: "A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction." [GOC:cb, GOC:mah, PMID:12636085] synonym: "type II PKS" EXACT [] synonym: "type II PKS complex" EXACT [] synonym: "type II polyketide synthase" EXACT [] is_a: GO:0034081 ! polyketide synthase complex [Term] id: GO:0034083 name: type III polyketide synthase complex namespace: cellular_component def: "A polyketide synthase complex that consists of two identical ketosynthase polypeptides." [GOC:cb, PMID:12636085] synonym: "type III PKS" EXACT [] synonym: "type III PKS complex" EXACT [] synonym: "type III polyketide synthase" EXACT [] is_a: GO:0034081 ! polyketide synthase complex [Term] id: GO:0034084 name: steryl deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol." [GOC:rb, PMID:18034159] synonym: "sterol deacetylase activity" EXACT [] is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0034085 name: establishment of sister chromatid cohesion namespace: biological_process def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase." [GOC:mah, PMID:14623866] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007062 ! sister chromatid cohesion [Term] id: GO:0034086 name: maintenance of sister chromatid cohesion namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate." [GOC:mah, PMID:14623866] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007062 ! sister chromatid cohesion [Term] id: GO:0034087 name: establishment of mitotic sister chromatid cohesion namespace: biological_process def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle." [GOC:mah] is_a: GO:0034085 ! establishment of sister chromatid cohesion relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion [Term] id: GO:0034088 name: maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah] synonym: "mitotic cohesion stability" RELATED [] is_a: GO:0034086 ! maintenance of sister chromatid cohesion relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion [Term] id: GO:0034089 name: establishment of meiotic sister chromatid cohesion namespace: biological_process def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle." [GOC:mah] is_a: GO:0034085 ! establishment of sister chromatid cohesion relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion [Term] id: GO:0034090 name: maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:mah] is_a: GO:0034086 ! maintenance of sister chromatid cohesion relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion [Term] id: GO:0034091 name: regulation of maintenance of sister chromatid cohesion namespace: biological_process def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] is_a: GO:0007063 ! regulation of sister chromatid cohesion relationship: regulates GO:0034086 ! maintenance of sister chromatid cohesion [Term] id: GO:0034092 name: negative regulation of maintenance of sister chromatid cohesion namespace: biological_process def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion is_a: GO:0045875 ! negative regulation of sister chromatid cohesion relationship: negatively_regulates GO:0034086 ! maintenance of sister chromatid cohesion [Term] id: GO:0034093 name: positive regulation of maintenance of sister chromatid cohesion namespace: biological_process def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion is_a: GO:0045876 ! positive regulation of sister chromatid cohesion relationship: positively_regulates GO:0034086 ! maintenance of sister chromatid cohesion [Term] id: GO:0034094 name: regulation of maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion is_a: GO:0040020 ! regulation of meiosis relationship: regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion [Term] id: GO:0034095 name: negative regulation of maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion relationship: negatively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion [Term] id: GO:0034096 name: positive regulation of maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion relationship: positively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion [Term] id: GO:0034097 name: response to cytokine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0034098 name: Cdc48p-Npl4p-Ufd1p AAA ATPase complex namespace: cellular_component def: "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins." [PMID:11813000, PMID:16179952] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0034099 name: luminal surveillance complex namespace: cellular_component def: "A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins." [PMID:16873065] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005788 ! endoplasmic reticulum lumen [Term] id: GO:0034101 name: erythrocyte homeostasis namespace: biological_process def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] synonym: "RBC homeostasis" EXACT [CL:0000232] synonym: "red blood cell homeostasis" EXACT [CL:0000232] is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0034102 name: erythrocyte clearance namespace: biological_process def: "The selective elimination of erythrocytes from the body by autoregulatory mechanisms." [GOC:add, PMID:12905029, PMID:14754397] comment: Note that this term is intended for annotation of self-gene products that lead to elimination of erythrocytes without the involvement of a symbiont. synonym: "neocytolysis" NARROW [PMID:14754397] synonym: "RBC clearance" EXACT [CL:0000232] synonym: "red blood cell clearance" EXACT [CL:0000232] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0034101 ! erythrocyte homeostasis [Term] id: GO:0034103 name: regulation of tissue remodeling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0048771 ! tissue remodeling [Term] id: GO:0034104 name: negative regulation of tissue remodeling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add] is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0048771 ! tissue remodeling [Term] id: GO:0034105 name: positive regulation of tissue remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add] is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0048771 ! tissue remodeling [Term] id: GO:0034106 name: regulation of erythrocyte clearance namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] synonym: "regulation of neocytolysis" NARROW [PMID:14754397] synonym: "regulation of RBC clearance" EXACT [CL:0000232] synonym: "regulation of red blood cell clearance" EXACT [CL:0000232] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0034103 ! regulation of tissue remodeling relationship: regulates GO:0034102 ! erythrocyte clearance [Term] id: GO:0034107 name: negative regulation of erythrocyte clearance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] synonym: "negative regulation of neocytolysis" NARROW [PMID:14754397] synonym: "negative regulation of RBC clearance" EXACT [CL:0000232] synonym: "negative regulation of red blood cell clearance" EXACT [CL:0000232] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0034106 ! regulation of erythrocyte clearance relationship: negatively_regulates GO:0034102 ! erythrocyte clearance [Term] id: GO:0034108 name: positive regulation of erythrocyte clearance namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] synonym: "positive regulation of neocytolysis" NARROW [PMID:14754397] synonym: "positive regulation of RBC clearance" EXACT [CL:0000232] synonym: "positive regulation of red blood cell clearance" EXACT [CL:0000232] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0034106 ! regulation of erythrocyte clearance relationship: positively_regulates GO:0034102 ! erythrocyte clearance [Term] id: GO:0034109 name: homotypic cell-cell adhesion namespace: biological_process def: "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add] comment: Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms. is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0034110 name: regulation of homotypic cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] is_a: GO:0022407 ! regulation of cell-cell adhesion relationship: regulates GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034111 name: negative regulation of homotypic cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion relationship: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034112 name: positive regulation of homotypic cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion relationship: positively_regulates GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034113 name: heterotypic cell-cell adhesion namespace: biological_process def: "The attachment of a cell to a cell of a different type via adhesion molecules." [GOC:add] comment: Note that this term is not synonymous with 'heterophilic cell adhesion ; GO:0007157'; the process may occur by homophilic or heterophilic mechanisms. is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0034114 name: regulation of heterotypic cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] is_a: GO:0022407 ! regulation of cell-cell adhesion relationship: regulates GO:0034113 ! heterotypic cell-cell adhesion [Term] id: GO:0034115 name: negative regulation of heterotypic cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion is_a: GO:0070587 ! regulation of cell-cell adhesion involved in gastrulation relationship: negatively_regulates GO:0034113 ! heterotypic cell-cell adhesion [Term] id: GO:0034116 name: positive regulation of heterotypic cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion is_a: GO:0070587 ! regulation of cell-cell adhesion involved in gastrulation relationship: positively_regulates GO:0034113 ! heterotypic cell-cell adhesion [Term] id: GO:0034117 name: erythrocyte aggregation namespace: biological_process def: "The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules." [GOC:add, PMID:14631543] synonym: "RBC aggregation" EXACT [CL:0000232] synonym: "red blood cell aggregation" EXACT [CL:0000232] is_a: GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034118 name: regulation of erythrocyte aggregation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] synonym: "regulation of RBC aggregation" EXACT [CL:0000232] synonym: "regulation of red blood cell aggregation" EXACT [CL:0000232] is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion relationship: regulates GO:0034117 ! erythrocyte aggregation [Term] id: GO:0034119 name: negative regulation of erythrocyte aggregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] synonym: "negative regulation of RBC aggregation" EXACT [CL:0000232] synonym: "negative regulation of red blood cell aggregation" EXACT [CL:0000232] is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion is_a: GO:0034118 ! regulation of erythrocyte aggregation relationship: negatively_regulates GO:0034117 ! erythrocyte aggregation [Term] id: GO:0034120 name: positive regulation of erythrocyte aggregation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] synonym: "positive regulation of RBC aggregation" EXACT [CL:0000232] synonym: "positive regulation of red blood cell aggregation" EXACT [CL:0000232] is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion is_a: GO:0034118 ! regulation of erythrocyte aggregation relationship: positively_regulates GO:0034117 ! erythrocyte aggregation [Term] id: GO:0034121 name: regulation of toll-like receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR signaling pathway" EXACT [] synonym: "regulation of toll-like receptor signalling pathway" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034122 name: negative regulation of toll-like receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor signalling pathway" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: negatively_regulates GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034123 name: positive regulation of toll-like receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor signalling pathway" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: positively_regulates GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034124 name: regulation of MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation ofMyD88-dependent TLR signaling pathway" EXACT [] synonym: "regulation ofMyD88-dependent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway [Term] id: GO:0034125 name: negative regulation of MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of MyD88-dependent TLR signaling pathway" EXACT [] synonym: "negative regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway relationship: negatively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway [Term] id: GO:0034126 name: positive regulation of MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of MyD88-dependent TLR signaling pathway" EXACT [] synonym: "positive regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway relationship: positively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway [Term] id: GO:0034127 name: regulation of MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation ofMyD88-independent TLR signaling pathway" EXACT [] synonym: "regulation ofMyD88-independent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway [Term] id: GO:0034128 name: negative regulation of MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of MyD88-independent TLR signaling pathway" EXACT [] synonym: "negative regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway relationship: negatively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway [Term] id: GO:0034129 name: positive regulation of MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of MyD88-independent TLR signaling pathway" EXACT [] synonym: "positive regulation of MyD88-independent toll-like receptor" EXACT [] synonym: "positive regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway relationship: positively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway [Term] id: GO:0034130 name: toll-like receptor 1 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 1." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR1 signaling pathway" EXACT [] synonym: "toll-like receptor 1 signalling pathway" EXACT [] xref: Reactome:1253147 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1280081 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1298963 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1326652 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1352764 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1372975 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1392991 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1417471 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1450564 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1471071 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1483087 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1496962 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1514349 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1521221 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1526810 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:1532536 "Toll Like Receptor TLR1:TLR2 Cascade" xref: Reactome:168179 "Toll Like Receptor TLR1:TLR2 Cascade" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034131 name: regulation of toll-like receptor 1 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR1 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 1 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034130 ! toll-like receptor 1 signaling pathway [Term] id: GO:0034132 name: negative regulation of toll-like receptor 1 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR1 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 1 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway relationship: negatively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway [Term] id: GO:0034133 name: positive regulation of toll-like receptor 1 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR1 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 1 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway relationship: positively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway [Term] id: GO:0034134 name: toll-like receptor 2 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 2." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR2 signaling pathway" EXACT [] synonym: "toll-like receptor 2 signalling pathway" EXACT [] xref: Reactome:1253148 "Toll Like Receptor 2 Cascade" xref: Reactome:1280082 "Toll Like Receptor 2 Cascade" xref: Reactome:1298964 "Toll Like Receptor 2 Cascade" xref: Reactome:1326653 "Toll Like Receptor 2 Cascade" xref: Reactome:1352765 "Toll Like Receptor 2 Cascade" xref: Reactome:1372976 "Toll Like Receptor 2 Cascade" xref: Reactome:1392992 "Toll Like Receptor 2 Cascade" xref: Reactome:1417472 "Toll Like Receptor 2 Cascade" xref: Reactome:1450565 "Toll Like Receptor 2 Cascade" xref: Reactome:1471072 "Toll Like Receptor 2 Cascade" xref: Reactome:1483088 "Toll Like Receptor 2 Cascade" xref: Reactome:1496963 "Toll Like Receptor 2 Cascade" xref: Reactome:1514350 "Toll Like Receptor 2 Cascade" xref: Reactome:1521222 "Toll Like Receptor 2 Cascade" xref: Reactome:1526811 "Toll Like Receptor 2 Cascade" xref: Reactome:1532537 "Toll Like Receptor 2 Cascade" xref: Reactome:181438 "Toll Like Receptor 2 Cascade" xref: Reactome:517856 "TLR2 subfamily cascade" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034135 name: regulation of toll-like receptor 2 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR2 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 2 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034134 ! toll-like receptor 2 signaling pathway [Term] id: GO:0034136 name: negative regulation of toll-like receptor 2 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR2 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 2 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway relationship: negatively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway [Term] id: GO:0034137 name: positive regulation of toll-like receptor 2 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR2 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 2 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway relationship: positively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway [Term] id: GO:0034138 name: toll-like receptor 3 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 3." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR3 signaling pathway" EXACT [] synonym: "toll-like receptor 3 signalling pathway" EXACT [] xref: Reactome:1253151 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1280085 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1298967 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1326656 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1352768 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1372979 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1392995 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1417475 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1450568 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1471075 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1483091 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1496966 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1514353 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1521225 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1526814 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:1532540 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:168164 "Toll Like Receptor 3 (TLR3) Cascade" xref: Reactome:434048 "TLR3 cascade" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034139 name: regulation of toll-like receptor 3 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR3 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 3 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034138 ! toll-like receptor 3 signaling pathway [Term] id: GO:0034140 name: negative regulation of toll-like receptor 3 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR3 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 3 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway relationship: negatively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway [Term] id: GO:0034141 name: positive regulation of toll-like receptor 3 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR3 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 3 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway relationship: positively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway [Term] id: GO:0034142 name: toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 4." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR4 signaling pathway" EXACT [] synonym: "toll-like receptor 4 signalling pathway" EXACT [] xref: Reactome:1253143 "Activated TLR4 signalling" xref: Reactome:1280077 "Activated TLR4 signalling" xref: Reactome:1298958 "Activated TLR4 signalling" xref: Reactome:1326648 "Activated TLR4 signalling" xref: Reactome:1352760 "Activated TLR4 signalling" xref: Reactome:1372971 "Activated TLR4 signalling" xref: Reactome:1392987 "Activated TLR4 signalling" xref: Reactome:1417467 "Activated TLR4 signalling" xref: Reactome:1450560 "Activated TLR4 signalling" xref: Reactome:1471066 "Activated TLR4 signalling" xref: Reactome:1483082 "Activated TLR4 signalling" xref: Reactome:1496957 "Activated TLR4 signalling" xref: Reactome:1514344 "Activated TLR4 signalling" xref: Reactome:1521217 "Activated TLR4 signalling" xref: Reactome:1526805 "Activated TLR4 signalling" xref: Reactome:1532531 "Activated TLR4 signalling" xref: Reactome:166054 "Activated TLR4 signalling" xref: Reactome:433794 "TLR4 cascade" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034143 name: regulation of toll-like receptor 4 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR4 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 4 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034142 ! toll-like receptor 4 signaling pathway [Term] id: GO:0034144 name: negative regulation of toll-like receptor 4 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR4 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 4 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway relationship: negatively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway [Term] id: GO:0034145 name: positive regulation of toll-like receptor 4 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR4 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 4 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway relationship: positively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway [Term] id: GO:0034146 name: toll-like receptor 5 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 5." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR5 signaling pathway" EXACT [] synonym: "toll-like receptor 5 signalling pathway" EXACT [] xref: Reactome:451534 "TLR5 cascade" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034147 name: regulation of toll-like receptor 5 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR5 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 5 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034146 ! toll-like receptor 5 signaling pathway [Term] id: GO:0034148 name: negative regulation of toll-like receptor 5 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR5 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 5 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway relationship: negatively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway [Term] id: GO:0034149 name: positive regulation of toll-like receptor 5 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR5 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 5 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway relationship: positively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway [Term] id: GO:0034150 name: toll-like receptor 6 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 6." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR6 signaling pathway" EXACT [] synonym: "toll-like receptor 6 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034151 name: regulation of toll-like receptor 6 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR6 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 6 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034150 ! toll-like receptor 6 signaling pathway [Term] id: GO:0034152 name: negative regulation of toll-like receptor 6 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR6 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 6 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway relationship: negatively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway [Term] id: GO:0034153 name: positive regulation of toll-like receptor 6 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR6 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 6 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway relationship: positively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway [Term] id: GO:0034154 name: toll-like receptor 7 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 7." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR7 signaling pathway" EXACT [] synonym: "toll-like receptor 7 signalling pathway" EXACT [] xref: Reactome:451498 "TLR7 cascade" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034155 name: regulation of toll-like receptor 7 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR7 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 7 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034154 ! toll-like receptor 7 signaling pathway [Term] id: GO:0034156 name: negative regulation of toll-like receptor 7 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR7 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 7 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway relationship: negatively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway [Term] id: GO:0034157 name: positive regulation of toll-like receptor 7 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR7 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 7 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway relationship: positively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway [Term] id: GO:0034158 name: toll-like receptor 8 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 8." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR8 signaling pathway" EXACT [] synonym: "toll-like receptor 8 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034159 name: regulation of toll-like receptor 8 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR8 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 8 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034158 ! toll-like receptor 8 signaling pathway [Term] id: GO:0034160 name: negative regulation of toll-like receptor 8 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR8 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 8 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway relationship: negatively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway [Term] id: GO:0034161 name: positive regulation of toll-like receptor 8 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR8 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 8 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway relationship: positively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway [Term] id: GO:0034162 name: toll-like receptor 9 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 9." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR9 signaling pathway" EXACT [] synonym: "toll-like receptor 9 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034163 name: regulation of toll-like receptor 9 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR9 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 9 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034162 ! toll-like receptor 9 signaling pathway [Term] id: GO:0034164 name: negative regulation of toll-like receptor 9 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR9 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 9 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway relationship: negatively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway [Term] id: GO:0034165 name: positive regulation of toll-like receptor 9 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR9 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 9 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway relationship: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway [Term] id: GO:0034166 name: toll-like receptor 10 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 10." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR10 signaling pathway" EXACT [] synonym: "toll-like receptor 10 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034167 name: regulation of toll-like receptor 10 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR10 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 10 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034166 ! toll-like receptor 10 signaling pathway [Term] id: GO:0034168 name: negative regulation of toll-like receptor 10 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR10 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 10 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway relationship: negatively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway [Term] id: GO:0034169 name: positive regulation of toll-like receptor 10 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR10 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 10 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway relationship: positively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway [Term] id: GO:0034170 name: toll-like receptor 11 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 11." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR11 signaling pathway" EXACT [] synonym: "toll-like receptor 11 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034171 name: regulation of toll-like receptor 11 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR11 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 11 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034170 ! toll-like receptor 11 signaling pathway [Term] id: GO:0034172 name: negative regulation of toll-like receptor 11 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR11 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 11 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway relationship: negatively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway [Term] id: GO:0034173 name: positive regulation of toll-like receptor 11 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR11 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 11 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway relationship: positively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway [Term] id: GO:0034174 name: toll-like receptor 12 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 12." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR12 signaling pathway" EXACT [] synonym: "toll-like receptor 12 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034175 name: regulation of toll-like receptor 12 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR12 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 12 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034174 ! toll-like receptor 12 signaling pathway [Term] id: GO:0034176 name: negative regulation of toll-like receptor 12 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR12 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 12 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway relationship: negatively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway [Term] id: GO:0034177 name: positive regulation of toll-like receptor 12 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR12 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 12 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway relationship: positively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway [Term] id: GO:0034178 name: toll-like receptor 13 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 13." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR13 signaling pathway" EXACT [] synonym: "toll-like receptor 13 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034179 name: regulation of toll-like receptor 13 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR13 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 13 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0034178 ! toll-like receptor 13 signaling pathway [Term] id: GO:0034180 name: negative regulation of toll-like receptor 13 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR13 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 13 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway relationship: negatively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway [Term] id: GO:0034181 name: positive regulation of toll-like receptor 13 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR13 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 13 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway relationship: positively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway [Term] id: GO:0034182 name: regulation of maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion relationship: regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion [Term] id: GO:0034183 name: negative regulation of maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion relationship: negatively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion [Term] id: GO:0034184 name: positive regulation of maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion relationship: positively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion [Term] id: GO:0034185 name: apolipoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex." [GOC:BHF, GOC:rl] is_a: GO:0005515 ! protein binding [Term] id: GO:0034186 name: apolipoprotein A-I binding namespace: molecular_function def: "Interacting selectively and non-covalently with apolipoprotein A-I." [GOC:BHF, GOC:rl] is_a: GO:0034185 ! apolipoprotein binding [Term] id: GO:0034187 name: apolipoprotein E binding namespace: molecular_function def: "Interacting selectively and non-covalently with apolipoprotein E." [GOC:BHF, GOC:rl] is_a: GO:0034185 ! apolipoprotein binding [Term] id: GO:0034188 name: apolipoprotein A-I receptor activity namespace: molecular_function def: "Combining with apolipoprotein A-I to initiate a change in cell activity." [GOC:BHF, GOC:rl] is_a: GO:0030226 ! apolipoprotein receptor activity is_a: GO:0034186 ! apolipoprotein A-I binding [Term] id: GO:0034189 name: very-low-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm." [GOC:BHF, GOC:mah] synonym: "very-low-density lipoprotein particle binding" EXACT [GOC:dph] synonym: "VLDL binding" EXACT [] is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0034190 name: apolipoprotein receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an apolipoprotein receptor." [GOC:BHF, GOC:rl] is_a: GO:0005102 ! receptor binding [Term] id: GO:0034191 name: apolipoprotein A-I receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an apolipoprotein A-I receptor." [GOC:BHF, GOC:rl] comment: Note that this term is to be used only to annotate gene products that bind to lipid-free APOA1. For receptors that bind lipid-associated apolipoproteins (plasma lipoprotein particles), consider annotating to 'lipoprotein receptor activity ; GO:0030228' or its child terms. is_a: GO:0034190 ! apolipoprotein receptor binding [Term] id: GO:0034192 name: D-galactonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid." [GOC:mah] subset: gosubset_prok synonym: "D-galactonate metabolism" EXACT [] is_a: GO:0019583 ! galactonate metabolic process [Term] id: GO:0034193 name: L-galactonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid." [GOC:mah] subset: gosubset_prok synonym: "L-galactonate metabolism" EXACT [] is_a: GO:0019583 ! galactonate metabolic process [Term] id: GO:0034194 name: D-galactonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid." [GOC:ai, GOC:mah] subset: gosubset_prok synonym: "D-galactonate breakdown" EXACT [] synonym: "D-galactonate catabolism" EXACT [] synonym: "D-galactonate degradation" EXACT [] xref: MetaCyc:GALACTCAT-PWY is_a: GO:0019584 ! galactonate catabolic process is_a: GO:0034192 ! D-galactonate metabolic process [Term] id: GO:0034195 name: L-galactonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid." [GOC:ai, GOC:mah] subset: gosubset_prok synonym: "L-galactonate breakdown" EXACT [] synonym: "L-galactonate catabolism" EXACT [] synonym: "L-galactonate degradation" EXACT [] xref: MetaCyc:GALACTCAT-PWY is_a: GO:0019584 ! galactonate catabolic process is_a: GO:0034193 ! L-galactonate metabolic process [Term] id: GO:0034196 name: acylglycerol transport namespace: biological_process def: "The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl] synonym: "glyceride transport" EXACT [] is_a: GO:0006869 ! lipid transport [Term] id: GO:0034197 name: triglyceride transport namespace: biological_process def: "The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [GOC:BHF, GOC:rl] synonym: "triacylglycerol transport" EXACT [] is_a: GO:0034196 ! acylglycerol transport [Term] id: GO:0034198 name: cellular response to amino acid starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0034199 name: activation of protein kinase A activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme protein kinase A." [GOC:pde] synonym: "protein kinase A activation" EXACT [] xref: Reactome:1253199 "PKA activation" xref: Reactome:1280133 "PKA activation" xref: Reactome:1299013 "PKA activation" xref: Reactome:1326705 "PKA activation" xref: Reactome:1352817 "PKA activation" xref: Reactome:1373026 "PKA activation" xref: Reactome:1393043 "PKA activation" xref: Reactome:1417519 "PKA activation" xref: Reactome:1450615 "PKA activation" xref: Reactome:1471117 "PKA activation" xref: Reactome:1483125 "PKA activation" xref: Reactome:1521077 "PKA activation" xref: Reactome:1526855 "PKA activation" xref: Reactome:1532582 "PKA activation" xref: Reactome:1539293 "PKA activation" xref: Reactome:163615 "PKA activation" is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0034200 name: D,D-heptose 1,7-bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate." [MetaCyc:RXN0-4361, PMID:11279237] xref: MetaCyc:RXN0-4361 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0034201 name: response to oleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [CHEBI:16196, GOC:lp] synonym: "response to oleate" EXACT [GOC:mah] is_a: GO:0070542 ! response to fatty acid [Term] id: GO:0034202 name: glycolipid-translocating activity namespace: molecular_function def: "Catalysis of the movement of glycolipids from one membrane face to the other (glycolipid 'flippase' activity)." [GOC:krc, PMID:11807558] synonym: "flippase activity" BROAD [] xref: Reactome:261950 "glycolipid-translocating activity" is_a: GO:0017089 ! glycolipid transporter activity [Term] id: GO:0034203 name: glycolipid translocation namespace: biological_process def: "The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, PMID:11807558] subset: gosubset_prok synonym: "flippase" RELATED [] synonym: "scramblase" RELATED [] is_a: GO:0034204 ! lipid translocation is_a: GO:0046836 ! glycolipid transport [Term] id: GO:0034204 name: lipid translocation namespace: biological_process def: "The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:mah] is_a: GO:0006869 ! lipid transport is_a: GO:0097035 ! regulation of membrane lipid distribution [Term] id: GO:0034205 name: beta-amyloid formation namespace: biological_process def: "The generation of beta-amyloid by cleavage of the amyloid precursor protein (APP)." [GOC:mah] comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because beta-amyloid can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. is_a: GO:0042987 ! amyloid precursor protein catabolic process is_a: GO:0050435 ! beta-amyloid metabolic process [Term] id: GO:0034206 name: enhanceosome namespace: cellular_component def: "A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation." [PMID:11250145, PMID:17574024] xref: Wikipedia:Enhanceosome is_a: GO:0032993 ! protein-DNA complex [Term] id: GO:0034207 name: steroid acetylation namespace: biological_process def: "The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0030258 ! lipid modification [Term] id: GO:0034208 name: steroid deacetylation namespace: biological_process def: "The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0030258 ! lipid modification [Term] id: GO:0034209 name: sterol acetylation namespace: biological_process def: "The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0034207 ! steroid acetylation [Term] id: GO:0034210 name: sterol deacetylation namespace: biological_process def: "The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0034208 ! steroid deacetylation [Term] id: GO:0034211 name: GTP-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of GTP." [GOC:ecd, PMID:17200152] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0034212 name: peptide N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide." [GOC:mah] subset: gosubset_prok is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0034213 name: quinolinate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:mah] synonym: "quinolinate breakdown" EXACT [] synonym: "quinolinate catabolism" EXACT [] synonym: "quinolinate degradation" EXACT [] is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0046874 ! quinolinate metabolic process [Term] id: GO:0034214 name: protein hexamerization namespace: biological_process def: "The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits." [GOC:ecd] subset: gosubset_prok synonym: "protein hexamer assembly" EXACT [] synonym: "protein hexamer biosynthesis" EXACT [] synonym: "protein hexamer biosynthetic process" EXACT [] synonym: "protein hexamer formation" EXACT [] is_a: GO:0051259 ! protein oligomerization [Term] id: GO:0034215 name: thiamine:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in)." [GOC:mah] synonym: "thiamin:hydrogen symporter activity" EXACT [GOC:curators] synonym: "thiamin:proton symporter activity" EXACT [] synonym: "thiamine:proton symporter activity" EXACT [] is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015403 ! thiamine uptake transmembrane transporter activity [Term] id: GO:0034216 name: high-affinity thiamine:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] synonym: "high affinity thiamin:hydrogen symporter activity" EXACT [] synonym: "high-affinity thiamin:hydrogen symporter activity" EXACT [GOC:curators] synonym: "high-affinity thiamin:proton symporter activity" EXACT [] synonym: "high-affinity thiamine:proton symporter activity" EXACT [] is_a: GO:0034215 ! thiamine:hydrogen symporter activity [Term] id: GO:0034217 name: ascospore wall chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw] synonym: "ascospore wall chitin anabolism" EXACT [] synonym: "ascospore wall chitin biosynthesis" EXACT [] synonym: "ascospore wall chitin formation" EXACT [] synonym: "ascospore wall chitin synthesis" EXACT [] is_a: GO:0034218 ! ascospore wall chitin metabolic process is_a: GO:0034221 ! fungal-type cell wall chitin biosynthetic process is_a: GO:0044106 ! cellular amine metabolic process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0070591 ! ascospore wall biogenesis [Term] id: GO:0034218 name: ascospore wall chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw] synonym: "ascospore wall chitin metabolism" EXACT [] is_a: GO:0006037 ! cell wall chitin metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process [Term] id: GO:0034219 name: carbohydrate transmembrane transport namespace: biological_process def: "The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0034220 name: ion transmembrane transport namespace: biological_process def: "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb] xref: Reactome:1253724 "Ion transport by P-type ATPases" xref: Reactome:1253725 "Ion channel transport" xref: Reactome:1280655 "Ion transport by P-type ATPases" xref: Reactome:1280656 "Ion channel transport" xref: Reactome:1299481 "Ion transport by P-type ATPases" xref: Reactome:1299482 "Ion channel transport" xref: Reactome:1327241 "Ion transport by P-type ATPases" xref: Reactome:1327242 "Ion channel transport" xref: Reactome:1353336 "Ion transport by P-type ATPases" xref: Reactome:1353337 "Ion channel transport" xref: Reactome:1373509 "Ion transport by P-type ATPases" xref: Reactome:1373510 "Ion channel transport" xref: Reactome:1393531 "Ion transport by P-type ATPases" xref: Reactome:1393532 "Ion channel transport" xref: Reactome:1418032 "Ion transport by P-type ATPases" xref: Reactome:1418033 "Ion channel transport" xref: Reactome:1451121 "Ion transport by P-type ATPases" xref: Reactome:1451122 "Ion channel transport" xref: Reactome:1471474 "Ion transport by P-type ATPases" xref: Reactome:1471475 "Ion channel transport" xref: Reactome:1483411 "Ion transport by P-type ATPases" xref: Reactome:1483412 "Ion channel transport" xref: Reactome:1497064 "Ion transport by P-type ATPases" xref: Reactome:1497065 "Ion channel transport" xref: Reactome:1514451 "Ion transport by P-type ATPases" xref: Reactome:1514452 "Ion channel transport" xref: Reactome:1521321 "Ion transport by P-type ATPases" xref: Reactome:1521322 "Ion channel transport" xref: Reactome:1527023 "Ion transport by P-type ATPases" xref: Reactome:1527024 "Ion channel transport" xref: Reactome:1532757 "Ion transport by P-type ATPases" xref: Reactome:1532758 "Ion channel transport" xref: Reactome:1536135 "Ion transport by P-type ATPases" xref: Reactome:1536136 "Ion channel transport" xref: Reactome:1539376 "Ion transport by P-type ATPases" xref: Reactome:1539377 "Ion channel transport" xref: Reactome:936837 "Ion transport by P-type ATPases" xref: Reactome:975298 "Ligand-gated ion channel transport" xref: Reactome:983712 "Ion channel transport" is_a: GO:0006811 ! ion transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0034221 name: fungal-type cell wall chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells." [GOC:mah] synonym: "fungal-type cell wall chitin anabolism" EXACT [] synonym: "fungal-type cell wall chitin biosynthesis" EXACT [] synonym: "fungal-type cell wall chitin formation" EXACT [] synonym: "fungal-type cell wall chitin synthesis" EXACT [] is_a: GO:0006038 ! cell wall chitin biosynthetic process is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process [Term] id: GO:0034222 name: regulation of cell wall chitin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall." [GOC:mah] synonym: "regulation of cell wall chitin metabolism" EXACT [] is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0032882 ! regulation of chitin metabolic process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0006037 ! cell wall chitin metabolic process [Term] id: GO:0034223 name: regulation of ascospore wall chitin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin." [GOC:mah] synonym: "regulation of ascospore wall chitin anabolism" EXACT [] synonym: "regulation of ascospore wall chitin biosynthesis" EXACT [] synonym: "regulation of ascospore wall chitin formation" EXACT [] synonym: "regulation of ascospore wall chitin synthesis" EXACT [] is_a: GO:0032884 ! regulation of cell wall chitin biosynthetic process is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0034307 ! regulation of ascospore formation relationship: regulates GO:0034217 ! ascospore wall chitin biosynthetic process [Term] id: GO:0034224 name: cellular response to zinc ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions." [GOC:mah] synonym: "ellular response to zinc ion limitation" EXACT [] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0034225 name: regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of zinc ions." [GOC:mah] synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc deficiency" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc ion limitation" EXACT [] is_a: GO:0034224 ! cellular response to zinc ion starvation is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress [Term] id: GO:0034226 name: lysine import namespace: biological_process def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:jl, GOC:mah] synonym: "L-lysine import" NARROW [] synonym: "lysine uptake" EXACT [] is_a: GO:0015819 ! lysine transport is_a: GO:0043090 ! amino acid import [Term] id: GO:0034227 name: tRNA thio-modification namespace: biological_process def: "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066] subset: gosubset_prok synonym: "tRNA sulfurtransferase activity" RELATED [GOC:mah] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0034228 name: ethanolamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ethanolamine from one side of the membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579] subset: gosubset_prok synonym: "2-aminoethanol transmembrane transporter activity" EXACT [] synonym: "ethanolamine permease activity" EXACT [] synonym: "monoethanolamine transmembrane transporter activity" EXACT [] is_a: GO:0005275 ! amine transmembrane transporter activity [Term] id: GO:0034229 name: ethanolamine transport namespace: biological_process def: "The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579] synonym: "2-aminoethanol transport" EXACT [] synonym: "monoethanolamine transport" EXACT [] is_a: GO:0015837 ! amine transport is_a: GO:0015850 ! organic alcohol transport [Term] id: GO:0034230 name: enkephalin processing namespace: biological_process def: "The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide." [GOC:BHF, GOC:mah, GOC:rl, PMID:8262946] synonym: "enkephalin formation" EXACT [] synonym: "peptide enkephalin formation" EXACT [] synonym: "peptide enkephalin processing" EXACT [] is_a: GO:0016486 ! peptide hormone processing [Term] id: GO:0034231 name: islet amyloid polypeptide processing namespace: biological_process def: "The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP)." [GOC:BHF, GOC:rl, PMID:15983213, PMID:8262946] synonym: "IAPP formation" EXACT [] synonym: "IAPP processing" EXACT [] synonym: "islet amyloid peptide formation" EXACT [] synonym: "islet amyloid peptide processing" EXACT [] synonym: "islet amyloid polypeptide formation" RELATED [] is_a: GO:0016486 ! peptide hormone processing [Term] id: GO:0034232 name: ascospore wall chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall chitin breakdown" EXACT [] synonym: "ascospore wall chitin catabolism" EXACT [] synonym: "ascospore wall chitin degradation" EXACT [] is_a: GO:0006039 ! cell wall chitin catabolic process is_a: GO:0034218 ! ascospore wall chitin metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0071854 ! cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly [Term] id: GO:0034233 name: regulation of cell wall chitin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin." [GOC:mah] synonym: "regulation of cell wall chitin breakdown" EXACT [] synonym: "regulation of cell wall chitin catabolism" EXACT [] synonym: "regulation of cell wall chitin degradation" EXACT [] is_a: GO:0034222 ! regulation of cell wall chitin metabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process relationship: regulates GO:0006039 ! cell wall chitin catabolic process [Term] id: GO:0034234 name: regulation of ascospore wall chitin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of ascospore wall chitin." [GOC:mah] synonym: "regulation of ascospore wall chitin breakdown" EXACT [] synonym: "regulation of ascospore wall chitin catabolism" EXACT [] synonym: "regulation of ascospore wall chitin degradation" EXACT [] is_a: GO:0034233 ! regulation of cell wall chitin catabolic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0060237 ! regulation of fungal-type cell wall organization relationship: regulates GO:0034232 ! ascospore wall chitin catabolic process [Term] id: GO:0034235 name: GPI anchor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw] comment: Note that this term should be used to annotate gene products that interact non-covalently with GPI anchors, and not proteins that have GPI anchors covalently attached. synonym: "glycosylphosphatidylinositol binding" EXACT [] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0034236 name: protein kinase A catalytic subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A." [GOC:mah] synonym: "PKA catalytic subunit binding" EXACT [] is_a: GO:0019901 ! protein kinase binding is_a: GO:0051018 ! protein kinase A binding [Term] id: GO:0034237 name: protein kinase A regulatory subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A." [GOC:mah] synonym: "PKA regulatory subunit binding" EXACT [] synonym: "protein kinase A anchoring activity" RELATED [] is_a: GO:0051018 ! protein kinase A binding [Term] id: GO:0034238 name: macrophage fusion namespace: biological_process def: "The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell." [GOC:sl] is_a: GO:0000768 ! syncytium formation by plasma membrane fusion [Term] id: GO:0034239 name: regulation of macrophage fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage fusion." [GOC:mah] is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion relationship: regulates GO:0034238 ! macrophage fusion [Term] id: GO:0034240 name: negative regulation of macrophage fusion namespace: biological_process def: "Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion." [GOC:mah] is_a: GO:0034239 ! regulation of macrophage fusion is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion relationship: negatively_regulates GO:0034238 ! macrophage fusion [Term] id: GO:0034241 name: positive regulation of macrophage fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage fusion." [GOC:mah] is_a: GO:0034239 ! regulation of macrophage fusion is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion relationship: positively_regulates GO:0034238 ! macrophage fusion [Term] id: GO:0034242 name: negative regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion relationship: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion [Term] id: GO:0034243 name: regulation of transcription elongation from RNA polymerase II promoter namespace: biological_process alt_id: GO:0090039 def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] synonym: "regulation of RNA elongation from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0032784 ! regulation of transcription elongation, DNA-dependent relationship: regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter [Term] id: GO:0034244 name: negative regulation of transcription elongation from RNA polymerase II promoter namespace: biological_process alt_id: GO:0090041 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "negative regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] synonym: "negative regulation of RNA elongation from RNA polymerase II promoter" EXACT [] is_a: GO:0032785 ! negative regulation of transcription elongation, DNA-dependent is_a: GO:0034243 ! regulation of transcription elongation from RNA polymerase II promoter relationship: negatively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter [Term] id: GO:0034245 name: mitochondrial DNA-directed RNA polymerase complex namespace: cellular_component def: "A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form." [GOC:krc, GOC:mah, PMID:7929382] synonym: "mitochondrial RNA polymerase complex" BROAD [] synonym: "mitochondrial RNA polymerase holoenzyme complex" EXACT [] is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0034246 name: mitochondrial RNA polymerase binding promoter specificity activity namespace: molecular_function alt_id: GO:0000998 def: "An activity that binds to mitochondrial RNA polymerase and which while present in a complex with the mitochondrial RNA polymerase confers sequence specific recognition of mitochondrial promoter DNA sequence motifs." [GOC:txnOH] synonym: "mitochondrial polymerase transcription factor activity" EXACT [] synonym: "mitochondrial transcription factor activity" RELATED [] synonym: "mitochondrial transcription initiation factor activity" EXACT [] is_a: GO:0000996 ! core RNA polymerase binding promoter specificity activity [Term] id: GO:0034247 name: snoRNA splicing namespace: biological_process def: "The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA." [GOC:mah] is_a: GO:0008380 ! RNA splicing is_a: GO:0043144 ! snoRNA processing [Term] id: GO:0034248 name: regulation of cellular amide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "regulation of amide metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: regulates GO:0043603 ! cellular amide metabolic process [Term] id: GO:0034249 name: negative regulation of cellular amide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "negative regulation of amide metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process relationship: negatively_regulates GO:0043603 ! cellular amide metabolic process [Term] id: GO:0034250 name: positive regulation of cellular amide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "positive regulation of amide metabolism" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process relationship: positively_regulates GO:0043603 ! cellular amide metabolic process [Term] id: GO:0034251 name: regulation of cellular amide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "regulation of amide breakdown" EXACT [] synonym: "regulation of amide catabolism" EXACT [] synonym: "regulation of amide degradation" EXACT [] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process relationship: regulates GO:0043605 ! cellular amide catabolic process [Term] id: GO:0034252 name: negative regulation of cellular amide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "negative regulation of amide breakdown" EXACT [] synonym: "negative regulation of amide catabolism" EXACT [] synonym: "negative regulation of amide degradation" RELATED [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0034251 ! regulation of cellular amide catabolic process relationship: negatively_regulates GO:0043605 ! cellular amide catabolic process [Term] id: GO:0034253 name: positive regulation of cellular amide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "positive regulation of amide breakdown" EXACT [] synonym: "positive regulation of amide catabolism" EXACT [] synonym: "positive regulation of amide degradation" RELATED [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0034251 ! regulation of cellular amide catabolic process relationship: positively_regulates GO:0043605 ! cellular amide catabolic process [Term] id: GO:0034254 name: regulation of urea catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea." [GOC:mah] synonym: "regulation of urea breakdown" EXACT [] synonym: "regulation of urea catabolism" EXACT [] synonym: "regulation of urea degradation" EXACT [] is_a: GO:0034251 ! regulation of cellular amide catabolic process is_a: GO:0034255 ! regulation of urea metabolic process relationship: regulates GO:0043419 ! urea catabolic process [Term] id: GO:0034255 name: regulation of urea metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea." [GOC:mah] synonym: "regulation of urea metabolism" EXACT [] is_a: GO:0034248 ! regulation of cellular amide metabolic process relationship: regulates GO:0019627 ! urea metabolic process [Term] id: GO:0034256 name: chlorophyll(ide) b reductase activity namespace: molecular_function def: "Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+." [EC:1.1.1.294, MetaCyc:RXN-7678] synonym: "Chl b reductase activity" EXACT [] synonym: "chlorophyll b reductase activity" EXACT [] synonym: "chlorophyllide b reductase activity" EXACT [] xref: EC:1.1.1.294 xref: MetaCyc:RXN-7678 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0034257 name: nicotinamide riboside transporter activity namespace: molecular_function def: "Catalysis of the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other." [GOC:se] is_a: GO:0005337 ! nucleoside transmembrane transporter activity [Term] id: GO:0034258 name: nicotinamide riboside transport namespace: biological_process def: "The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:se] is_a: GO:0015858 ! nucleoside transport [Term] id: GO:0034259 name: negative regulation of Rho GTPase activity namespace: biological_process def: "Any process that stops or reduces the rate of activity of a GTPase of the Rho family." [GOC:mah] synonym: "down regulation of Rho GTPase activity" EXACT [] synonym: "down-regulation of Rho GTPase activity" EXACT [] synonym: "downregulation of Rho GTPase activity" EXACT [] synonym: "inhibition of Rho GTPase activity" NARROW [] is_a: GO:0032319 ! regulation of Rho GTPase activity is_a: GO:0034261 ! negative regulation of Ras GTPase activity [Term] id: GO:0034260 name: negative regulation of GTPase activity namespace: biological_process def: "Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GOC:mah] synonym: "down regulation of GTPase activity" EXACT [] synonym: "down-regulation of GTPase activity" EXACT [] synonym: "downregulation of GTPase activity" EXACT [] synonym: "inhibition of GTPase activity" NARROW [] synonym: "negative regulation of guanosinetriphosphatase activity" EXACT [] is_a: GO:0043087 ! regulation of GTPase activity is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0034261 name: negative regulation of Ras GTPase activity namespace: biological_process def: "Any process that stops or reduces the rate of activity of a GTPase of the Ras superfamily." [GOC:mah] synonym: "down regulation of Ras GTPase activity" EXACT [] synonym: "down-regulation of Ras GTPase activity" EXACT [] synonym: "downregulation of Ras GTPase activity" EXACT [] synonym: "inhibition of Ras GTPase activity" NARROW [] is_a: GO:0032318 ! regulation of Ras GTPase activity is_a: GO:0034260 ! negative regulation of GTPase activity [Term] id: GO:0034263 name: autophagy in response to ER overload namespace: biological_process def: "The process in which cells digest parts of their own cytoplasm in response to the accumulation of misfolded proteins in the endoplasmic reticulum." [GOC:mah] synonym: "autophagy in response to endoplasmic reticulum overload" EXACT [] synonym: "autophagy in response to ER stress" EXACT [] is_a: GO:0006914 ! autophagy is_a: GO:0006983 ! ER overload response [Term] id: GO:0034264 name: isopentenyl adenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] synonym: "isopentenyl adenine metabolism" EXACT [] synonym: "isopentenyladenine metabolic process" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process [Term] id: GO:0034265 name: isopentenyl adenine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] subset: gosubset_prok synonym: "isopentenyl adenine anabolism" EXACT [] synonym: "isopentenyl adenine biosynthesis" EXACT [] synonym: "isopentenyl adenine formation" EXACT [] synonym: "isopentenyl adenine synthesis" EXACT [] synonym: "isopentenyladenine biosynthetic process" EXACT [] is_a: GO:0009691 ! cytokinin biosynthetic process is_a: GO:0034264 ! isopentenyl adenine metabolic process [Term] id: GO:0034266 name: isopentenyl adenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] subset: gosubset_prok synonym: "isopentenyl adenine breakdown" EXACT [] synonym: "isopentenyl adenine catabolism" EXACT [] synonym: "isopentenyl adenine degradation" EXACT [] synonym: "isopentenyladenine catabolic process" EXACT [] is_a: GO:0009823 ! cytokinin catabolic process is_a: GO:0034264 ! isopentenyl adenine metabolic process [Term] id: GO:0034267 name: discadenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [CHEBI:15955, GOC:mah] synonym: "discadenine metabolism" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process [Term] id: GO:0034268 name: discadenine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [CHEBI:15955, GOC:mah] synonym: "discadenine anabolism" EXACT [] synonym: "discadenine biosynthesis" EXACT [] synonym: "discadenine formation" EXACT [] synonym: "discadenine synthesis" EXACT [] is_a: GO:0009691 ! cytokinin biosynthetic process is_a: GO:0034267 ! discadenine metabolic process [Term] id: GO:0034269 name: discadenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [CHEBI:15955, GOC:mah] synonym: "discadenine breakdown" EXACT [] synonym: "discadenine catabolism" EXACT [] synonym: "discadenine degradation" EXACT [] is_a: GO:0009823 ! cytokinin catabolic process is_a: GO:0034267 ! discadenine metabolic process [Term] id: GO:0034270 name: CVT complex namespace: cellular_component def: "A protein complex that is involved in the CVT pathway. In budding yeast, the CVT complex consists of multimers of preApe1p." [GOC:rb, PMID:15659643] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034271 name: phosphatidylinositol 3-kinase complex I namespace: cellular_component def: "A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Atg14p and Vps15p." [GOC:rb, PMID:11157979, PMID:16421251] comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. synonym: "PtdIns-3-kinase complex I" EXACT [] is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex [Term] id: GO:0034272 name: phosphatidylinositol 3-kinase complex II namespace: cellular_component def: "A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, VPS38 and Vps15p." [GOC:rb, PMID:11157979, PMID:16421251] comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. synonym: "PtdIns-3-kinase complex II" EXACT [] is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex [Term] id: GO:0034273 name: Atg1p signaling complex namespace: cellular_component def: "A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p, Atg13p and Atg17p." [GOC:rb, PMID:15743910] synonym: "Atg1p signalling complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034274 name: Atg12-Atg5-Atg16 complex namespace: cellular_component def: "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p." [GOC:rb, PMID:17986448] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034275 name: kynurenic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [CHEBI:18344, GOC:mah] synonym: "4-hydroxyquinoline-2-carboxylic acid metabolic process" EXACT [] synonym: "kynurenic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0034276 name: kynurenic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [CHEBI:18344, GOC:mah] synonym: "4-hydroxyquinoline-2-carboxylic acid biosynthetic process" EXACT [] synonym: "kynurenic acid anabolism" EXACT [] synonym: "kynurenic acid biosynthesis" EXACT [] synonym: "kynurenic acid formation" RELATED [] synonym: "kynurenic acid synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0034275 ! kynurenic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0034277 name: ent-cassa-12,15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate." [EC:4.2.3.28, RHEA:25535] synonym: "ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity" EXACT systematic_synonym [EC:4.2.3.28, KEGG:R09119] xref: EC:4.2.3.28 xref: KEGG:R09119 xref: MetaCyc:RXN-4881 xref: RHEA:25535 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034278 name: stemar-13-ene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." [MetaCyc:RXN-4882, RHEA:25555] synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity" EXACT systematic_synonym [KEGG:R09115] xref: EC:4.2.3.33 xref: KEGG:R09115 xref: MetaCyc:RXN-4882 xref: RHEA:25555 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034279 name: syn-pimara-7,15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate." [MetaCyc:RXN-4883, RHEA:25563] synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity" EXACT systematic_synonym [KEGG:R09117] xref: EC:4.2.3.35 xref: KEGG:R09117 xref: MetaCyc:RXN-4883 xref: RHEA:25563 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034280 name: ent-sandaracopimaradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate." [MetaCyc:RXN-4884, RHEA:25539] synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG:R09120] synonym: "ent-pimaradiene synthase activity" BROAD [] xref: EC:4.2.3.29 xref: KEGG:R09120 xref: MetaCyc:RXN-4884 xref: RHEA:25539 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034281 name: ent-isokaurene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate." [PMID:17141283] is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0034282 name: ent-pimara-8(14),15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate." [RHEA:25543] synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG:R09121] synonym: "ent-pimaradiene synthase activity" BROAD [] xref: EC:4.2.3.30 xref: KEGG:R09121 xref: MetaCyc:RXN-7788 xref: RHEA:25543 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034283 name: syn-stemod-13(17)-ene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate." [RHEA:25559] synonym: "9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] activity" EXACT systematic_synonym [KEGG:R09116] synonym: "exo-stemodene synthase activity" EXACT [] synonym: "stemod-13(17)-ene synthase activity" EXACT [] synonym: "stemodene synthase activity" EXACT [] synonym: "syn-stemodene synthase activity" EXACT [] xref: EC:4.2.3.34 xref: KEGG:R09116 xref: MetaCyc:RXN-9291 xref: RHEA:25559 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034284 name: response to monosaccharide stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] is_a: GO:0009743 ! response to carbohydrate stimulus [Term] id: GO:0034285 name: response to disaccharide stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:sart] is_a: GO:0009743 ! response to carbohydrate stimulus [Term] id: GO:0034286 name: response to maltose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:sart] is_a: GO:0034285 ! response to disaccharide stimulus [Term] id: GO:0034287 name: detection of monosaccharide stimulus namespace: biological_process def: "The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal." [GOC:mah] synonym: "perception of monosaccharide stimulus" RELATED [] is_a: GO:0009730 ! detection of carbohydrate stimulus is_a: GO:0034284 ! response to monosaccharide stimulus [Term] id: GO:0034288 name: detection of disaccharide stimulus namespace: biological_process def: "The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal." [GOC:sart] synonym: "perception of disaccharide stimulus" RELATED [] is_a: GO:0009730 ! detection of carbohydrate stimulus is_a: GO:0034285 ! response to disaccharide stimulus [Term] id: GO:0034289 name: detection of maltose stimulus namespace: biological_process def: "The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal." [GOC:sart] synonym: "perception of maltose stimulus" RELATED [] is_a: GO:0034286 ! response to maltose stimulus is_a: GO:0034288 ! detection of disaccharide stimulus [Term] id: GO:0034290 name: holin activity namespace: molecular_function def: "Catalysis of the temporally-regulated formation of a transmembrane protein hole that directly or indirectly allows murein hydrolyases to access their cell wall substrate." [GOC:jh2, PMID:1406491] is_a: GO:0015267 ! channel activity [Term] id: GO:0034291 name: canonical holin activity namespace: molecular_function def: "Catalysis of the temporally-regulated formation of a non-specific transmembrane protein hole that allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell." [GOC:jh2, GOC:mah, PMID:1406491] is_a: GO:0034290 ! holin activity [Term] id: GO:0034292 name: pinholin activity namespace: molecular_function def: "Catalysis of the temporally-regulated formation of a transmembrane protein hole that allows the passage of ions, causing a lethal, irreversible depolarization of the cell membrane." [GOC:jh2, GOC:mah, PMID:1406491] is_a: GO:0034290 ! holin activity [Term] id: GO:0034293 name: sexual sporulation namespace: biological_process def: "The formation of spores derived from the products of meiosis." [GOC:mah] synonym: "meiotic spore formation" EXACT [] synonym: "meiotic sporulation" EXACT [] synonym: "sexual spore formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0019953 ! sexual reproduction is_a: GO:0043934 ! sporulation is_a: GO:0048610 ! cellular process involved in reproduction [Term] id: GO:0034294 name: sexual spore wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:mah] synonym: "sexual spore wall formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0042244 ! spore wall assembly is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0034293 ! sexual sporulation [Term] id: GO:0034295 name: basidiospore formation namespace: biological_process def: "The process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium." [GOC:ds, GOC:mah, http://www.gsbs.utmb.edu/microbook/ch073.htm, http://www.ilmyco.gen.chicago.il.us/Terms/basid133.html] is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034296 name: zygospore formation namespace: biological_process def: "The process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away." [GOC:ds, GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/zygos581.html] is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034297 name: oidium formation namespace: biological_process def: "The process in which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus." [GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/oidiu163.html] is_a: GO:0030436 ! asexual sporulation [Term] id: GO:0034298 name: arthrospore formation namespace: biological_process def: "The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#arthrospore, http://www.ilmyco.gen.chicago.il.us/Terms/arthr620.html] synonym: "arthroconidium formation" EXACT [http://medical.merriam-webster.com/medical/medical?book=Medical&va=arthroconidium] is_a: GO:0048315 ! conidium formation [Term] id: GO:0034299 name: reproductive blastospore formation namespace: biological_process def: "The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#blastospore, http://bugs.bio.usyd.edu.au/Mycology/Taxonomy/glomeromycota.shtml] comment: Note that this term should not be confused with the usage of 'blastospore' to mean any yeast-form fungal cell, as in Candida species. synonym: "blastoconidium formation" EXACT [http://cancerweb.ncl.ac.uk/cgi-bin/omd?Blastoconidium] is_a: GO:0048315 ! conidium formation [Term] id: GO:0034300 name: sporangiospore formation namespace: biological_process def: "The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:ds, GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_n_z.shtml] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034301 name: endospore formation namespace: biological_process def: "The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, ISBN:0470090278] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034302 name: akinete formation namespace: biological_process def: "The process in which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria." [GOC:ds, GOC:mah, http://www.msu.edu/course/bot/423/algalglossary.htm#Reproductive, PMID:11948167] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034303 name: myxospore formation namespace: biological_process def: "The process in which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, dessication, and UV than vegetative myxobacteria." [GOC:ds, ISBN:0122268008] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034304 name: actinomycete-type spore formation namespace: biological_process def: "The process in which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales." [GOC:ds, ISBN:0122268008] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022413 ! reproductive process in single-celled organism is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034305 name: regulation of asexual sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis." [GOC:mah] synonym: "regulation of asexual spore formation" EXACT [] synonym: "regulation of mitotic spore formation" EXACT [] synonym: "regulation of mitotic sporulation" EXACT [] is_a: GO:0043937 ! regulation of sporulation relationship: regulates GO:0030436 ! asexual sporulation [Term] id: GO:0034306 name: regulation of sexual sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae." [GOC:mah] synonym: "MAPKKK cascade during sporulation" RELATED [] synonym: "regulation of meiotic spore formation" EXACT [] synonym: "regulation of meiotic sporulation" EXACT [] synonym: "regulation of sexual spore formation" EXACT [] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0050794 ! regulation of cellular process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0034293 ! sexual sporulation [Term] id: GO:0034307 name: regulation of ascospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ascospore formation. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] synonym: "MAPKKK cascade during sporulation" RELATED [] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0030437 ! ascospore formation [Term] id: GO:0034308 name: primary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [CHEBI:15734, GOC:mah] subset: gosubset_prok synonym: "monohydric alcohol metabolic process" EXACT [GOC:curators] synonym: "primary alcohol metabolism" EXACT [GOC:mah] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0034309 name: primary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [CHEBI:15734, GOC:mah] subset: gosubset_prok synonym: "monohydric alcohol biosynthetic process" EXACT [GOC:curators] synonym: "primary alcohol anabolism" EXACT [GOC:mah] synonym: "primary alcohol biosynthesis" EXACT [GOC:mah] synonym: "primary alcohol formation" EXACT [GOC:mah] synonym: "primary alcohol synthesis" EXACT [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0034310 name: primary alcohol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [CHEBI:15734, GOC:mah] subset: gosubset_prok synonym: "monohydric alcohol catabolic process" EXACT [GOC:curators] synonym: "primary alcohol breakdown" EXACT [GOC:mah] synonym: "primary alcohol catabolism" EXACT [GOC:mah] synonym: "primary alcohol degradation" EXACT [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0034311 name: diol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [CHEBI:23824, GOC:mah] subset: gosubset_prok synonym: "dihydric alcohol metabolic process" EXACT [] synonym: "diol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0034312 name: diol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [CHEBI:23824, GOC:mah] synonym: "dihydric alcohol biosynthetic process" EXACT [] synonym: "diol anabolism" EXACT [] synonym: "diol biosynthesis" EXACT [] synonym: "diol formation" EXACT [] synonym: "diol synthesis" EXACT [] is_a: GO:0034311 ! diol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0034313 name: diol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [CHEBI:23824, GOC:mah] synonym: "dihydric alcohol catabolic process" EXACT [] synonym: "diol breakdown" EXACT [] synonym: "diol catabolism" EXACT [] synonym: "diol degradation" EXACT [] is_a: GO:0034311 ! diol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0034314 name: Arp2/3 complex-mediated actin nucleation namespace: biological_process def: "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983] synonym: "actin filament branch nucleation" EXACT [] synonym: "branched actin filament nucleation" EXACT [] is_a: GO:0045010 ! actin nucleation [Term] id: GO:0034315 name: regulation of Arp2/3 complex-mediated actin nucleation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah] is_a: GO:0051125 ! regulation of actin nucleation relationship: regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation [Term] id: GO:0034316 name: negative regulation of Arp2/3 complex-mediated actin nucleation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah, PMID:16959963] is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation is_a: GO:0051126 ! negative regulation of actin nucleation relationship: negatively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation [Term] id: GO:0034317 name: nicotinic acid riboside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide." [PMID:17914902] xref: MetaCyc:RXN-8443 is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0034318 name: alcohol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule." [GOC:mah] synonym: "acyl-CoA:alcohol O-acyltransferase activity" EXACT [] synonym: "acyl-CoA:ethanol O-acyltransferase" NARROW [] synonym: "acyl-coenzymeA:alcohol O-acyltransferase activity" EXACT [] synonym: "acyl-coenzymeA:ethanol O-acyltransferase activity" NARROW [] synonym: "AEATase activity" NARROW [] synonym: "alcohol acyltransferase activity" EXACT [] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0034319 name: alcohol O-butanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester." [GOC:mah, PMID:16361250] is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity is_a: GO:0034323 ! O-butanoyltransferase activity [Term] id: GO:0034320 name: alcohol O-hexanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester." [GOC:mah, PMID:16361250] is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity is_a: GO:0034324 ! O-hexanoyltransferase activity [Term] id: GO:0034321 name: alcohol O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester." [GOC:mah, PMID:16361250] is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0016414 ! O-octanoyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity [Term] id: GO:0034322 name: alcohol O-decanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester." [GOC:mah, PMID:16361250] is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity is_a: GO:0034325 ! O-decanoyltransferase activity [Term] id: GO:0034323 name: O-butanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule." [GOC:mah] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0034326 ! butanoyltransferase activity [Term] id: GO:0034324 name: O-hexanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule." [GOC:mah] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0034327 ! hexanoyltransferase activity [Term] id: GO:0034325 name: O-decanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule." [GOC:mah] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0034328 ! decanoyltransferase activity [Term] id: GO:0034326 name: butanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule." [GOC:mah] is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0034327 name: hexanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule." [GOC:mah] is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0034328 name: decanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule." [GOC:mah] is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0034329 name: cell junction assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] xref: Reactome:1253570 "Cell junction organization" xref: Reactome:1280663 "Cell junction organization" xref: Reactome:1299488 "Cell junction organization" xref: Reactome:1327087 "Cell junction organization" xref: Reactome:1353181 "Cell junction organization" xref: Reactome:1373517 "Cell junction organization" xref: Reactome:1393539 "Cell junction organization" xref: Reactome:1418039 "Cell junction organization" xref: Reactome:1451129 "Cell junction organization" xref: Reactome:1471506 "Cell junction organization" xref: Reactome:1483443 "Cell junction organization" xref: Reactome:1521345 "Cell junction organization" xref: Reactome:446728 "Cell junction organization" is_a: GO:0034330 ! cell junction organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0034330 name: cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_generic synonym: "cell junction assembly and maintenance" EXACT [] synonym: "cell junction biogenesis" RELATED [] is_a: GO:0009987 ! cellular process is_a: GO:0016043 ! cellular component organization [Term] id: GO:0034331 name: cell junction maintenance namespace: biological_process def: "The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0034330 ! cell junction organization is_a: GO:0071956 ! cellular component maintenance at cellular level [Term] id: GO:0034332 name: adherens junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah] synonym: "adherens junction assembly and maintenance" EXACT [] synonym: "adherens junction organisation" EXACT [GOC:curators] xref: Reactome:1253730 "Adherens junctions interactions" xref: Reactome:1280661 "Adherens junctions interactions" xref: Reactome:1299486 "Adherens junctions interactions" xref: Reactome:1327247 "Adherens junctions interactions" xref: Reactome:1353342 "Adherens junctions interactions" xref: Reactome:1373515 "Adherens junctions interactions" xref: Reactome:1393537 "Adherens junctions interactions" xref: Reactome:1418037 "Adherens junctions interactions" xref: Reactome:1451127 "Adherens junctions interactions" xref: Reactome:418990 "Adherens junctions interactions" is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0034333 name: adherens junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] synonym: "adherens junction formation" EXACT [] is_a: GO:0034329 ! cell junction assembly is_a: GO:0034332 ! adherens junction organization [Term] id: GO:0034334 name: adherens junction maintenance namespace: biological_process def: "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] is_a: GO:0034331 ! cell junction maintenance is_a: GO:0034332 ! adherens junction organization [Term] id: GO:0034335 name: DNA supercoiling activity namespace: molecular_function def: "OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule." [GOC:mah] comment: This term was made obsolete because, although it was requested, it is not needed after all; it was not defined clearly, and does not necessarily correspond to a catalytic activity. is_obsolete: true consider: GO:0015616 consider: GO:0032392 [Term] id: GO:0034336 name: misfolded RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule that has assumed an incorrect conformation." [GOC:mah, PMID:10393192] synonym: "RNA chaperone" RELATED [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0034337 name: RNA folding namespace: biological_process def: "The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure." [GOC:mah, PMID:10393192] synonym: "RNA chaperone" RELATED [] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0034338 name: short-chain carboxylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp] subset: gosubset_prok synonym: "butyrate esterase activity" NARROW [] synonym: "butyryl esterase activity" NARROW [] synonym: "methylbutyrase activity" NARROW [] synonym: "methylbutyrate esterase activity" NARROW [] synonym: "monobutyrase activity" NARROW [] synonym: "propionyl esterase activity" NARROW [] synonym: "short-chain esterase activity" BROAD [] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0034339 name: regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor namespace: biological_process def: "Any process in which a ligand-bound hormone receptor acts in the nucleus to modulate the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GO_REF:0000021, GOC:mah, GOC:mh] comment: This term was added by GO_REF:0000021. xref: Reactome:1253641 "Nuclear Receptor transcription pathway" xref: Reactome:1280573 "Nuclear Receptor transcription pathway" xref: Reactome:1299403 "Nuclear Receptor transcription pathway" xref: Reactome:1327158 "Nuclear Receptor transcription pathway" xref: Reactome:1353253 "Nuclear Receptor transcription pathway" xref: Reactome:1373427 "Nuclear Receptor transcription pathway" xref: Reactome:1393452 "Nuclear Receptor transcription pathway" xref: Reactome:1417953 "Nuclear Receptor transcription pathway" xref: Reactome:1451038 "Nuclear Receptor transcription pathway" xref: Reactome:1471411 "Nuclear Receptor transcription pathway" xref: Reactome:383280 "Nuclear Receptor transcription pathway" is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter [Term] id: GO:0034340 name: response to type I interferon namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "response to type I IFN" EXACT [] is_a: GO:0034097 ! response to cytokine stimulus relationship: part_of GO:0045087 ! innate immune response [Term] id: GO:0034341 name: response to interferon-gamma namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon." [GOC:add, ISBN:0126896631, PMID:15546383] synonym: "response to gamma-interferon" RELATED [] synonym: "response to immune interferon" EXACT [] synonym: "response to type II IFN" EXACT [] synonym: "response to type II interferon" EXACT [] is_a: GO:0034097 ! response to cytokine stimulus relationship: part_of GO:0045087 ! innate immune response [Term] id: GO:0034342 name: response to type III interferon namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] synonym: "response to interferon-lambda" EXACT [] synonym: "response to type III IFN" EXACT [] is_a: GO:0034097 ! response to cytokine stimulus relationship: part_of GO:0045087 ! innate immune response [Term] id: GO:0034343 name: type III interferon production namespace: biological_process def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "type III IFN production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0034344 name: regulation of type III interferon production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type III interferon production. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "regulation of type III IFN production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0034343 ! type III interferon production [Term] id: GO:0034345 name: negative regulation of type III interferon production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "down regulation of type III interferon production" EXACT [] synonym: "down-regulation of type III interferon production" EXACT [] synonym: "downregulation of type III interferon production" EXACT [] synonym: "inhibition of type III interferon production" NARROW [] synonym: "negative regulation of type III IFN production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0034344 ! regulation of type III interferon production relationship: negatively_regulates GO:0034343 ! type III interferon production [Term] id: GO:0034346 name: positive regulation of type III interferon production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type III interferon production. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "activation of type III interferon production" NARROW [] synonym: "positive regulation of type III IFN production" EXACT [] synonym: "stimulation of type III interferon production" NARROW [] synonym: "up regulation of type III interferon production" EXACT [] synonym: "up-regulation of type III interferon production" EXACT [] synonym: "upregulation of type III interferon production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0034344 ! regulation of type III interferon production relationship: positively_regulates GO:0034343 ! type III interferon production [Term] id: GO:0034347 name: type III interferon binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type III interferon. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "interferon-lambda binding" EXACT [] is_a: GO:0019961 ! interferon binding [Term] id: GO:0034348 name: type III interferon receptor activity namespace: molecular_function def: "Combining with a type III interferon to initiate a change in cell activity. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "interferon-lambda receptor activity" EXACT [] is_a: GO:0004904 ! interferon receptor activity is_a: GO:0034347 ! type III interferon binding [Term] id: GO:0034349 name: glial cell apoptosis namespace: biological_process def: "The process of apoptosis in glial cells." [GOC:sart] synonym: "apoptosis of glia" EXACT [] synonym: "apoptosis of glial cells" EXACT [] synonym: "glia apoptosis" EXACT [] synonym: "glia programmed cell death by apoptosis" EXACT [] synonym: "glial cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of glia by apoptosis" EXACT [] synonym: "programmed cell death of glial cells by apoptosis" EXACT [] synonym: "programmed cell death, glia" EXACT [] synonym: "programmed cell death, glial cells" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0034350 name: regulation of glial cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of glial cell apoptosis." [GOC:mah] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0034349 ! glial cell apoptosis [Term] id: GO:0034351 name: negative regulation of glial cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptosis." [GOC:mah] synonym: "down regulation of glial cell apoptosis" EXACT [] synonym: "down-regulation of glial cell apoptosis" EXACT [] synonym: "downregulation of glial cell apoptosis" EXACT [] synonym: "inhibition of glial cell apoptosis" NARROW [] is_a: GO:0034350 ! regulation of glial cell apoptosis is_a: GO:0043066 ! negative regulation of apoptosis relationship: negatively_regulates GO:0034349 ! glial cell apoptosis [Term] id: GO:0034352 name: positive regulation of glial cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptosis." [GOC:mah] synonym: "activation of glial cell apoptosis" NARROW [] synonym: "stimulation of glial cell apoptosis" NARROW [] synonym: "up regulation of glial cell apoptosis" EXACT [] synonym: "up-regulation of glial cell apoptosis" EXACT [] synonym: "upregulation of glial cell apoptosis" EXACT [] is_a: GO:0034350 ! regulation of glial cell apoptosis is_a: GO:0043065 ! positive regulation of apoptosis relationship: positively_regulates GO:0034349 ! glial cell apoptosis [Term] id: GO:0034353 name: RNA pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end." [GOC:jh2, PMID:17612492, PMID:18202662] is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0034354 name: de novo NAD biosynthetic process from tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [PMID:17161604] is_a: GO:0034627 ! de novo NAD biosynthetic process [Term] id: GO:0034355 name: NAD salvage namespace: biological_process def: "Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam)." [GOC:mah, PMID:12648681] synonym: "NAD salvage pathway" EXACT [] is_a: GO:0009435 ! NAD biosynthetic process [Term] id: GO:0034356 name: NAD biosynthesis via nicotinamide riboside salvage pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside." [PMID:17482543] synonym: "nicotinamide riboside salvage pathway" EXACT [] synonym: "NR salvage pathway" EXACT [] is_a: GO:0009435 ! NAD biosynthetic process [Term] id: GO:0034357 name: photosynthetic membrane namespace: cellular_component def: "A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place." [GOC:ds, GOC:mah] subset: gosubset_prok is_a: GO:0016020 ! membrane is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009579 ! thylakoid [Term] id: GO:0034358 name: plasma lipoprotein particle namespace: cellular_component def: "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." [GOC:BHF, GOC:expert_pt, GOC:rl] is_a: GO:0032994 ! protein-lipid complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0034359 name: mature chylomicron namespace: cellular_component def: "A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] is_a: GO:0042627 ! chylomicron [Term] id: GO:0034360 name: chylomicron remnant namespace: cellular_component def: "A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] is_a: GO:0042627 ! chylomicron [Term] id: GO:0034361 name: very-low-density lipoprotein particle namespace: cellular_component def: "A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "very-low-density lipoprotein complex" EXACT [] synonym: "VLDL complex" EXACT [] synonym: "VLDL particle" EXACT [] is_a: GO:0034385 ! triglyceride-rich lipoprotein particle [Term] id: GO:0034362 name: low-density lipoprotein particle namespace: cellular_component def: "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "LDL complex" EXACT [] synonym: "LDL particle" EXACT [] synonym: "low-density lipoprotein complex" EXACT [] is_a: GO:0034358 ! plasma lipoprotein particle [Term] id: GO:0034363 name: intermediate-density lipoprotein particle namespace: cellular_component def: "A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "IDL complex" EXACT [] synonym: "IDL particle" EXACT [] synonym: "intermediate-density lipoprotein complex" EXACT [] is_a: GO:0034385 ! triglyceride-rich lipoprotein particle [Term] id: GO:0034364 name: high-density lipoprotein particle namespace: cellular_component def: "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pde, GOC:rl] synonym: "HDL complex" EXACT [] synonym: "HDL particle" EXACT [] synonym: "HDL2" RELATED [] synonym: "HDL3" RELATED [] synonym: "high-density lipoprotein class complex" EXACT [] is_a: GO:0034358 ! plasma lipoprotein particle [Term] id: GO:0034365 name: discoidal high-density lipoprotein particle namespace: cellular_component def: "A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "discoidal HDL" EXACT [] synonym: "nascent HDL" EXACT [] synonym: "nascent high-density lipoprotein particle" EXACT [] is_a: GO:0034364 ! high-density lipoprotein particle [Term] id: GO:0034366 name: spherical high-density lipoprotein particle namespace: cellular_component def: "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "mature HDL" EXACT [] synonym: "mature high-density lipoprotein particle" EXACT [] synonym: "spherical HDL" EXACT [] is_a: GO:0034364 ! high-density lipoprotein particle [Term] id: GO:0034367 name: macromolecular complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:BHF, GOC:mah, GOC:mtg_mpo, GOC:rl] is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0034368 name: protein-lipid complex remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a protein-lipid complex." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0034367 ! macromolecular complex remodeling is_a: GO:0071825 ! protein-lipid complex subunit organization [Term] id: GO:0034369 name: plasma lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] is_a: GO:0034368 ! protein-lipid complex remodeling is_a: GO:0071827 ! plasma lipoprotein particle organization relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels [Term] id: GO:0034370 name: triglyceride-rich lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "triacylglycerol-rich lipoprotein particle remodeling" EXACT [GOC:mah] is_a: GO:0034369 ! plasma lipoprotein particle remodeling [Term] id: GO:0034371 name: chylomicron remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "chylomicron remnant formation" RELATED [] is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling [Term] id: GO:0034372 name: very-low-density lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "IDL formation" RELATED [] synonym: "intermediate-density lipoprotein particle formation" RELATED [] synonym: "VLDL remodeling" EXACT [] is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling [Term] id: GO:0034373 name: intermediate-density lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "IDL remodeling" EXACT [] synonym: "LDL formation" RELATED [] synonym: "low-density lipoprotein particle formation" RELATED [] is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling [Term] id: GO:0034374 name: low-density lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "LDL remodeling" EXACT [] synonym: "small dense LDL formation" RELATED [GOC:BHF] synonym: "small dense low-density lipoprotein particle formation" RELATED [GOC:BHF] is_a: GO:0034369 ! plasma lipoprotein particle remodeling [Term] id: GO:0034375 name: high-density lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "HDL remodeling" EXACT [] is_a: GO:0034369 ! plasma lipoprotein particle remodeling [Term] id: GO:0034376 name: conversion of discoidal high-density lipoprotein particle to spherical high-density lipoprotein particle namespace: biological_process def: "The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle." [GOC:BHF, GOC:mah, GOC:pde] synonym: "conversion of discoidal HDL to spherical HDL" EXACT [] synonym: "discoidal HDL remodeling" RELATED [] synonym: "discoidal high-density lipoprotein remodeling" RELATED [] is_a: GO:0034375 ! high-density lipoprotein particle remodeling [Term] id: GO:0034377 name: plasma lipoprotein particle assembly namespace: biological_process def: "The aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle." [GOC:BHF, GOC:mah] is_a: GO:0065005 ! protein-lipid complex assembly is_a: GO:0071827 ! plasma lipoprotein particle organization relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels [Term] id: GO:0034378 name: chylomicron assembly namespace: biological_process def: "The aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron." [GOC:BHF, GOC:mah] is_a: GO:0034377 ! plasma lipoprotein particle assembly [Term] id: GO:0034379 name: very-low-density lipoprotein particle assembly namespace: biological_process def: "The aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle." [GOC:BHF, GOC:mah] synonym: "VLDL assembly" EXACT [] is_a: GO:0034377 ! plasma lipoprotein particle assembly [Term] id: GO:0034380 name: high-density lipoprotein particle assembly namespace: biological_process def: "The aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:mah] synonym: "HDL assembly" EXACT [] is_a: GO:0034377 ! plasma lipoprotein particle assembly [Term] id: GO:0034381 name: plasma lipoprotein particle clearance namespace: biological_process def: "The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:mah, GOC:tb] synonym: "lipoprotein particle clearance" EXACT [GOC:mah] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels [Term] id: GO:0034382 name: chylomicron remnant clearance namespace: biological_process def: "The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF, GOC:mah, GOC:pde] is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance [Term] id: GO:0034383 name: low-density lipoprotein particle clearance namespace: biological_process def: "The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah] synonym: "LDL clearance" EXACT [] is_a: GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0034384 name: high-density lipoprotein particle clearance namespace: biological_process def: "The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah] synonym: "HDL clearance" EXACT [] is_a: GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0034385 name: triglyceride-rich lipoprotein particle namespace: cellular_component def: "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood." [GOC:BHF, GOC:mah, GOC:rl] synonym: "triacylglycerol-rich lipoprotein particle" EXACT [GOC:mah] is_a: GO:0034358 ! plasma lipoprotein particle [Term] id: GO:0034386 name: 4-aminobutyrate:2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate." [EC:2.6.1.19, GOC:mah] synonym: "4-aminobutanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyrate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyrate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyrate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-ketoglutaric acid transaminase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19] xref: MetaCyc:GABATRANSAM-RXN is_a: GO:0003867 ! 4-aminobutyrate transaminase activity [Term] id: GO:0034387 name: 4-aminobutyrate:pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine." [EC:2.6.1.19, GOC:mah] synonym: "gamma-aminobutyric acid pyruvate transaminase activity" EXACT [EC:2.6.1.19] xref: MetaCyc:RXN-6902 is_a: GO:0003867 ! 4-aminobutyrate transaminase activity [Term] id: GO:0034388 name: Pwp2p-containing subcomplex of 90S preribosome namespace: cellular_component def: "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "25-30 S subcomplex of 90S preribosome" EXACT [] synonym: "UTP-B complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044452 ! nucleolar part relationship: part_of GO:0030686 ! 90S preribosome [Term] id: GO:0034389 name: lipid particle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] synonym: "adiposome organization" EXACT [] synonym: "lipid body organization" EXACT [] synonym: "lipid droplet organization" EXACT [] synonym: "lipid particle organisation" EXACT [GOC:curators] synonym: "lipid particle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0034390 name: smooth muscle cell apoptosis namespace: biological_process def: "The process of apoptosis in smooth muscle cells. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:rl] synonym: "apoptosis of smooth muscle cells" EXACT [] synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT [] synonym: "programmed cell death, smooth muscle cells" EXACT [] synonym: "SMC apoptosis" EXACT [] synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT [] is_a: GO:0010657 ! muscle cell apoptosis [Term] id: GO:0034391 name: regulation of smooth muscle cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptosis." [GOC:BHF, GOC:rl] synonym: "regulation of SMC apoptosis" EXACT [] is_a: GO:0010660 ! regulation of muscle cell apoptosis relationship: regulates GO:0034390 ! smooth muscle cell apoptosis [Term] id: GO:0034392 name: negative regulation of smooth muscle cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptosis." [GOC:BHF, GOC:rl] synonym: "down regulation of smooth muscle cell apoptosis" EXACT [] synonym: "down-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "downregulation of smooth muscle cell apoptosis" EXACT [] synonym: "inhibition of smooth muscle cell apoptosis" NARROW [] synonym: "negative regulation of SMC apoptosis" EXACT [] is_a: GO:0010656 ! negative regulation of muscle cell apoptosis is_a: GO:0034391 ! regulation of smooth muscle cell apoptosis relationship: negatively_regulates GO:0034390 ! smooth muscle cell apoptosis [Term] id: GO:0034393 name: positive regulation of smooth muscle cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptosis." [GOC:BHF, GOC:rl] synonym: "activation of smooth muscle cell apoptosis" NARROW [] synonym: "positive regulation of SMC apoptosis" EXACT [] synonym: "stimulation of smooth muscle cell apoptosis" NARROW [] synonym: "up regulation of smooth muscle cell apoptosis" EXACT [] synonym: "up-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "upregulation of smooth muscle cell apoptosis" EXACT [] is_a: GO:0010661 ! positive regulation of muscle cell apoptosis is_a: GO:0034391 ! regulation of smooth muscle cell apoptosis relationship: positively_regulates GO:0034390 ! smooth muscle cell apoptosis [Term] id: GO:0034394 name: protein localization at cell surface namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah] synonym: "protein localisation at cell surface" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0034395 name: regulation of transcription from RNA polymerase II promoter in response to iron namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GO_REF:0000021, GOC:mah] comment: This term was added by GO_REF:0000021. synonym: "regulation of specific transcription from RNA polymerase II promoter in response to iron" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0071281 ! cellular response to iron ion [Term] id: GO:0034396 name: negative regulation of transcription from RNA polymerase II promoter in response to iron namespace: biological_process def: "Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:mah] synonym: "down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [] synonym: "negative regulation of transcription from Pol II promoter in response to iron" EXACT [] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron [Term] id: GO:0034397 name: telomere localization namespace: biological_process def: "Any process in which a telomere is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "telomere localisation" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization is_a: GO:0051641 ! cellular localization [Term] id: GO:0034398 name: telomere tethering at nuclear periphery namespace: biological_process def: "The process in which a telomere is maintained in a specific location at the nuclear periphery." [GOC:mah] is_a: GO:0034397 ! telomere localization [Term] id: GO:0034399 name: nuclear periphery namespace: cellular_component def: "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0034400 name: gerontoplast namespace: cellular_component def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:16151876] is_a: GO:0009536 ! plastid [Term] id: GO:0034401 name: regulation of transcription by chromatin organization namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators] synonym: "establishment or maintenance of chromatin architecture during transcription" EXACT [GOC:mah] is_a: GO:0006325 ! chromatin organization is_a: GO:0006355 ! regulation of transcription, DNA-dependent [Term] id: GO:0034402 name: recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex namespace: biological_process def: "The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript." [PMID:18195044] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0034403 name: alignment of 3' and 5' splice sites of nuclear mRNA namespace: biological_process def: "Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur." [GOC:krc, PMID:9430647] is_a: GO:0000389 ! nuclear mRNA 3'-splice site recognition is_a: GO:0000395 ! nuclear mRNA 5'-splice site recognition relationship: part_of GO:0000350 ! generation of catalytic spliceosome for second transesterification step [Term] id: GO:0034404 name: nucleobase, nucleoside and nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides." [GOC:mah] synonym: "nucleobase, nucleoside and nucleotide anabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide biosynthesis" EXACT [] synonym: "nucleobase, nucleoside and nucleotide formation" EXACT [] synonym: "nucleobase, nucleoside and nucleotide synthesis" EXACT [] is_a: GO:0034654 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process [Term] id: GO:0034405 name: response to fluid shear stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:sl] is_a: GO:0006950 ! response to stress [Term] id: GO:0034406 name: cell wall beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] subset: gosubset_prok synonym: "cell wall beta-glucan metabolism" EXACT [] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0034407 name: cell wall 1,3-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] subset: gosubset_prok synonym: "cell wall 1,3-beta-glucan metabolic process" BROAD [] synonym: "cell wall 1,3-beta-glucan metabolism" EXACT [] synonym: "cell wall beta-1,3 glucan metabolic process" EXACT [] synonym: "cell wall beta-1,3 glucan metabolism" EXACT [] is_a: GO:0006074 ! 1,3-beta-D-glucan metabolic process is_a: GO:0034406 ! cell wall beta-glucan metabolic process [Term] id: GO:0034408 name: ascospore wall beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall beta-glucan metabolism" EXACT [] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process relationship: part_of GO:0070591 ! ascospore wall biogenesis [Term] id: GO:0034409 name: ascospore wall 1,3-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall 1,3-beta-glucan metabolic process" BROAD [] synonym: "ascospore wall 1,3-beta-glucan metabolism" EXACT [GOC:mah] synonym: "ascospore wall beta-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "ascospore wall beta-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process is_a: GO:0071969 ! fungal-type cell wall 1,3-beta-D-glucan metabolic process [Term] id: GO:0034410 name: cell wall beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] subset: gosubset_prok synonym: "cell wall beta-glucan anabolism" EXACT [] synonym: "cell wall beta-glucan biosynthesis" EXACT [] synonym: "cell wall beta-glucan formation" EXACT [] synonym: "cell wall beta-glucan synthesis" EXACT [] is_a: GO:0034406 ! cell wall beta-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process [Term] id: GO:0034411 name: cell wall 1,3-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "cell wall 1,3-beta-glucan anabolism" EXACT [] synonym: "cell wall 1,3-beta-glucan biosynthesis" EXACT [] synonym: "cell wall 1,3-beta-glucan biosynthetic process" BROAD [] synonym: "cell wall 1,3-beta-glucan formation" EXACT [] synonym: "cell wall 1,3-beta-glucan synthesis" EXACT [] synonym: "cell wall beta-1,3-glucan anabolism" EXACT [] synonym: "cell wall beta-1,3-glucan biosynthesis" EXACT [] synonym: "cell wall beta-1,3-glucan biosynthetic process" EXACT [] synonym: "cell wall beta-1,3-glucan formation" EXACT [] synonym: "cell wall beta-1,3-glucan synthesis" EXACT [] is_a: GO:0006075 ! 1,3-beta-D-glucan biosynthetic process is_a: GO:0034407 ! cell wall 1,3-beta-D-glucan metabolic process is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process [Term] id: GO:0034412 name: ascospore wall beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall beta-glucan anabolism" EXACT [] synonym: "ascospore wall beta-glucan biosynthesis" EXACT [] synonym: "ascospore wall beta-glucan formation" EXACT [] synonym: "ascospore wall beta-glucan synthesis" EXACT [] is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process [Term] id: GO:0034413 name: ascospore wall 1,3-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall 1,3-beta-glucan anabolism" EXACT [] synonym: "ascospore wall 1,3-beta-glucan biosynthesis" EXACT [] synonym: "ascospore wall 1,3-beta-glucan biosynthetic process" BROAD [] synonym: "ascospore wall 1,3-beta-glucan formation" EXACT [] synonym: "ascospore wall 1,3-beta-glucan synthesis" EXACT [] synonym: "ascospore wall beta-1,3-glucan anabolism" EXACT [] synonym: "ascospore wall beta-1,3-glucan biosynthesis" EXACT [] synonym: "ascospore wall beta-1,3-glucan biosynthetic process" EXACT [] synonym: "ascospore wall beta-1,3-glucan formation" EXACT [] synonym: "ascospore wall beta-1,3-glucan synthesis" EXACT [] is_a: GO:0034409 ! ascospore wall 1,3-beta-D-glucan metabolic process is_a: GO:0034412 ! ascospore wall beta-glucan biosynthetic process is_a: GO:0071970 ! fungal-type cell wall 1,3-beta-D-glucan biosynthetic process [Term] id: GO:0034414 name: tRNA 3'-trailer cleavage, endonucleolytic namespace: biological_process def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah] synonym: "endonucleolytic tRNA 3'-end cleavage" EXACT [] synonym: "endonucleolytic tRNA 3'-trailer cleavage" RELATED [] synonym: "tRNA 3'-end cleavage, endonucleolytic" EXACT [] is_a: GO:0042779 ! tRNA 3'-trailer cleavage [Term] id: GO:0034415 name: tRNA 3'-trailer cleavage, exonucleolytic namespace: biological_process def: "Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah] synonym: "exonucleolytic tRNA 3'-end cleavage" EXACT [] synonym: "exonucleolytic tRNA 3'-trailer cleavage" EXACT [] synonym: "tRNA 3'-end cleavage, exonucleolytic" EXACT [] is_a: GO:0042779 ! tRNA 3'-trailer cleavage [Term] id: GO:0034416 name: bisphosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate." [EC:3.1.3.13, GOC:mah, PMID:18413611] synonym: "2,3-bisphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13] synonym: "2,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13] synonym: "2,3-diphosphoglyceric acid phosphatase activity" EXACT [EC:3.1.3.13] synonym: "diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13] synonym: "glycerate-2,3-diphosphate phosphatase activity" EXACT [EC:3.1.3.13] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0034417 name: bisphosphoglycerate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phosphoglycerate + phosphate." [EC:3.1.3.13, GOC:mah, PMID:18413611] synonym: "2,3-bisphospho-D-glycerate 3-phosphohydrolase activity" EXACT [EC:3.1.3.13] is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity [Term] id: GO:0034418 name: urate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine." [GOC:mah] synonym: "urate anabolism" RELATED [] synonym: "urate biosynthesis" EXACT [] synonym: "urate formation" EXACT [] synonym: "urate synthesis" EXACT [] synonym: "uric acid biosynthetic process" EXACT [] is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0046415 ! urate metabolic process [Term] id: GO:0034419 name: L-2-hydroxyglutarate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-hydroxyglutarate + O2 = 2-oxoglutarate + hydrogen peroxide." [PMID:18390652] is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity [Term] id: GO:0034420 name: co-translational protein acetylation namespace: biological_process def: "The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome." [GOC:mah] synonym: "co-translational protein amino acid acetylation" EXACT [GOC:bf] synonym: "cotranslational protein amino acid acetylation" EXACT [] is_a: GO:0006473 ! protein acetylation is_a: GO:0043686 ! co-translational protein modification [Term] id: GO:0034421 name: post-translational protein acetylation namespace: biological_process def: "The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome." [GOC:mah] synonym: "post-translational protein amino acid acetylation" EXACT [GOC:bf] synonym: "posttranslational protein amino acid acetylation" EXACT [] is_a: GO:0006473 ! protein acetylation is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0034422 name: aleurone grain lumen namespace: cellular_component def: "The volume enclosed by the membrane of an aleurone grain." [GOC:rph] is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0033095 ! aleurone grain [Term] id: GO:0034423 name: autophagic vacuole lumen namespace: cellular_component def: "The volume enclosed within the autophagic vacuole membrane." [GOC:rph] comment: Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation. is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0005776 ! autophagic vacuole [Term] id: GO:0034424 name: Vps55/Vps68 complex namespace: cellular_component def: "A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins." [PMID:18216282] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0034425 name: etioplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0034426 name: etioplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a etioplast and form the etioplast envelope." [GOC:rph] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0034425 ! etioplast envelope [Term] id: GO:0034427 name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:krc, GOC:mah] synonym: "3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic [Term] id: GO:0034428 name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [GOC:krc, GOC:mah] synonym: "5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic [Term] id: GO:0034429 name: tectobulbar tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain." [GOC:dsf, PMID:15065115, PMID:17507550, PMID:8038988] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0034430 name: monolayer-surrounded lipid storage body outer lipid monolayer namespace: cellular_component def: "The single layer of phopholipids surrounding a lipid storage body." [GOC:rph] synonym: "lipid droplet outer lipid monolayer" RELATED [] synonym: "lipid storage body surface lipid monolayer" EXACT [] synonym: "oil body outer lipid monolayer" EXACT [] synonym: "oleosome outer lipid monolayer" EXACT [] synonym: "spherosome outer lipid monolayer" EXACT [] is_a: GO:0034646 ! organelle-enclosing lipid monolayer is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0012511 ! monolayer-surrounded lipid storage body [Term] id: GO:0034431 name: bis(5'-adenosyl)-hexaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008] synonym: "AP(6)A hydrolase activity" EXACT [] synonym: "AP-6-A hydrolase activity" EXACT [] synonym: "AP6A hydrolase activity" EXACT [] synonym: "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity" EXACT [] is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0034432 name: bis(5'-adenosyl)-pentaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate." [PMID:10085096, PMID:9450008] synonym: "AP(5)A hydrolase activity" EXACT [] synonym: "AP-5-A hydrolase activity" EXACT [] synonym: "AP5A hydrolase activity" EXACT [] synonym: "Ap5a pyrophosphohydrolase activity" EXACT [GOC:tb] synonym: "diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity" EXACT [] is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0034433 name: steroid esterification namespace: biological_process def: "A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0030258 ! lipid modification [Term] id: GO:0034434 name: sterol esterification namespace: biological_process def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl] is_a: GO:0034433 ! steroid esterification [Term] id: GO:0034435 name: cholesterol esterification namespace: biological_process def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl] is_a: GO:0034434 ! sterol esterification [Term] id: GO:0034436 name: glycoprotein transport namespace: biological_process def: "The directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0015031 ! protein transport [Term] id: GO:0034437 name: glycoprotein transporter activity namespace: molecular_function def: "Enables the directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0008565 ! protein transporter activity [Term] id: GO:0034438 name: lipoprotein amino acid oxidation namespace: biological_process def: "The modification of a lipoprotein by oxidation of one or more amino acids in the protein." [GOC:BHF, GOC:mah] subset: gosubset_prok is_a: GO:0018158 ! protein oxidation is_a: GO:0042161 ! lipoprotein oxidation [Term] id: GO:0034439 name: lipoprotein lipid oxidation namespace: biological_process def: "The modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:mah] subset: gosubset_prok is_a: GO:0034440 ! lipid oxidation is_a: GO:0042161 ! lipoprotein oxidation [Term] id: GO:0034440 name: lipid oxidation namespace: biological_process def: "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GOC:BHF, GOC:mah] is_a: GO:0030258 ! lipid modification is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0034441 name: plasma lipoprotein particle oxidation namespace: biological_process def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group, occurring in the blood plasma." [GOC:BHF, GOC:mah] synonym: "plasma lipoprotein oxidation" EXACT [GOC:dph] is_a: GO:0042161 ! lipoprotein oxidation [Term] id: GO:0034442 name: regulation of lipoprotein oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah] is_a: GO:0050746 ! regulation of lipoprotein metabolic process relationship: regulates GO:0042161 ! lipoprotein oxidation [Term] id: GO:0034443 name: negative regulation of lipoprotein oxidation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah] synonym: "inhibition of lipoprotein oxidation" NARROW [] is_a: GO:0034442 ! regulation of lipoprotein oxidation is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process relationship: negatively_regulates GO:0042161 ! lipoprotein oxidation [Term] id: GO:0034444 name: regulation of plasma lipoprotein particle oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah] synonym: "regulation of plasma lipoprotein particle oxidation" EXACT [GOC:dph] is_a: GO:0034442 ! regulation of lipoprotein oxidation relationship: regulates GO:0034441 ! plasma lipoprotein particle oxidation [Term] id: GO:0034445 name: negative regulation of plasma lipoprotein particle oxidation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah] synonym: "inhibition of plasma lipoprotein oxidation" NARROW [] synonym: "negative regulation of plasma lipoprotein oxidation" EXACT [GOC:dph] is_a: GO:0034443 ! negative regulation of lipoprotein oxidation is_a: GO:0034444 ! regulation of plasma lipoprotein particle oxidation relationship: negatively_regulates GO:0034441 ! plasma lipoprotein particle oxidation [Term] id: GO:0034446 name: substrate adhesion-dependent cell spreading namespace: biological_process def: "The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732] synonym: "cell spreading during cell substrate adhesion" EXACT [] synonym: "substrate adhesion dependent cell spreading" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0031589 ! cell-substrate adhesion [Term] id: GO:0034447 name: very-low-density lipoprotein particle clearance namespace: biological_process def: "The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:rl] synonym: "VLDL clearance" EXACT [] is_a: GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0034448 name: EGO complex namespace: cellular_component def: "A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Meh1p, Gtr2p and Slm4p." [GOC:rb, PMID:15989961] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0034449 name: GSE complex namespace: cellular_component def: "A conserved protein complex required for protein sorting from endosome to the plasma membrane. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Slm4p, Meh1p and Ltv1p and it sorts Gap1p." [GOC:rb, PMID:15989961] synonym: "GTPase-containing complex for Gap1p sorting in the endosome" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044440 ! endosomal part [Term] id: GO:0034450 name: ubiquitin-ubiquitin ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine. This reaction is the ligation of ubiquitin groups, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603] synonym: "E4" EXACT [] xref: Reactome:357881 "ubiquitin-ubiquitin ligase activity" is_a: GO:0004842 ! ubiquitin-protein ligase activity [Term] id: GO:0034451 name: centriolar satellite namespace: cellular_component def: "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0034452 name: dynactin binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0034453 name: microtubule anchoring namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0032507 ! maintenance of protein location in cell [Term] id: GO:0034454 name: microtubule anchoring at centrosome namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah] is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center [Term] id: GO:0034455 name: t-UTP complex namespace: cellular_component def: "A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p." [GOC:mah, PMID:17515605] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "Nan1p-containing subcomplex of 90S preribosome" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044452 ! nucleolar part relationship: part_of GO:0030686 ! 90S preribosome [Term] id: GO:0034456 name: UTP-C complex namespace: cellular_component def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p." [GOC:mah, PMID:17515605] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "Rrp7p-containing subcomplex of 90S preribosome" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044452 ! nucleolar part relationship: part_of GO:0030686 ! 90S preribosome [Term] id: GO:0034457 name: Mpp10 complex namespace: cellular_component def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p." [GOC:mah, PMID:17515605] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. is_a: GO:0043234 ! protein complex is_a: GO:0044452 ! nucleolar part relationship: part_of GO:0030686 ! 90S preribosome [Term] id: GO:0034458 name: 3'-5' RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of an RNA helix in the direction 3' to 5'." [GOC:mah] synonym: "3' to 5' RNA helicase activity" EXACT [] is_a: GO:0003724 ! RNA helicase activity [Term] id: GO:0034459 name: ATP-dependent 3'-5' RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'." [GOC:jp] synonym: "ATP-dependent 3' to 5' RNA helicase activity" EXACT [] is_a: GO:0004004 ! ATP-dependent RNA helicase activity is_a: GO:0034458 ! 3'-5' RNA helicase activity [Term] id: GO:0034460 name: uropod assembly namespace: biological_process def: "The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane." [GOC:mah] synonym: "uropod formation" EXACT [GOC:mah] is_a: GO:0030031 ! cell projection assembly is_a: GO:0032796 ! uropod organization [Term] id: GO:0034461 name: uropod retraction namespace: biological_process def: "The process in which a uropod detaches from the cell substrate and retracts the rear of a migrating cell." [GOC:mah, PMID:10704379] is_a: GO:0032796 ! uropod organization [Term] id: GO:0034462 name: small-subunit processome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome." [GOC:mah] synonym: "small subunit processome assembly" EXACT [] synonym: "SSU processome assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000028 ! ribosomal small subunit assembly [Term] id: GO:0034463 name: 90S preribosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome." [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000027 ! ribosomal large subunit assembly relationship: part_of GO:0000028 ! ribosomal small subunit assembly [Term] id: GO:0034464 name: BBSome namespace: cellular_component def: "A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030] synonym: "Bardet-Biedl syndrome complex" EXACT [] is_a: GO:0043234 ! protein complex [Term] id: GO:0034465 name: response to carbon monoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:ecd] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0034466 name: chromaffin granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of a chromaffin granule." [GOC:rph] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0042583 ! chromaffin granule [Term] id: GO:0034467 name: esterosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an esterosome." [GOC:rph] is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0033117 ! esterosome [Term] id: GO:0034468 name: glycosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of a glycosome." [GOC:rph] is_a: GO:0005782 ! peroxisomal matrix relationship: part_of GO:0020015 ! glycosome [Term] id: GO:0034469 name: Golgi stack lumen namespace: cellular_component def: "The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex." [GOC:mah] is_a: GO:0005796 ! Golgi lumen relationship: part_of GO:0005795 ! Golgi stack [Term] id: GO:0034470 name: ncRNA processing namespace: biological_process def: "Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah] is_a: GO:0006396 ! RNA processing is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0034471 name: ncRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of a non-coding RNA molecule." [GOC:mah] synonym: "ncRNA 5' end processing" EXACT [] is_a: GO:0000966 ! RNA 5'-end processing is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0034472 name: snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah] synonym: "snRNA 3' end processing" EXACT [] is_a: GO:0016180 ! snRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0034473 name: U1 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U1 snRNA molecule." [GOC:mah] synonym: "U1 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034474 name: U2 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U2 snRNA molecule." [GOC:mah] synonym: "U2 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034475 name: U4 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U4 snRNA molecule." [GOC:mah] synonym: "U4 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034476 name: U5 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U5 snRNA molecule." [GOC:mah] synonym: "U5 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034477 name: U6 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U6 snRNA molecule." [GOC:mah] synonym: "U6 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034478 name: phosphatidylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [GOC:mah] subset: gosubset_prok synonym: "phosphatidylglycerol breakdown" EXACT [] synonym: "phosphatidylglycerol catabolism" EXACT [] synonym: "phosphatidylglycerol degradation" EXACT [] is_a: GO:0046471 ! phosphatidylglycerol metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0034479 name: phosphatidylglycerol phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate." [GOC:mah, PMID:18434318] is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0034480 name: phosphatidylcholine phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1,2-diacylglycerol + a choline phosphate." [EC:3.1.4.3, GOC:mah] subset: gosubset_prok synonym: "alpha-toxin" NARROW [EC:3.1.4.3] synonym: "Clostridium oedematiens beta- and gamma-toxins activity" NARROW [EC:3.1.4.3] synonym: "Clostridium welchii alpha-toxin activity" NARROW [EC:3.1.4.3] synonym: "heat-labile hemolysin" NARROW [EC:3.1.4.3] synonym: "lipophosphodiesterase I activity" EXACT [EC:3.1.4.3] synonym: "phosphatidylcholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.3] synonym: "phospholipase C, acting on phosphatidylcholine" EXACT [] xref: EC:3.1.4.3 xref: MetaCyc:PHOSPHOLIPASE-C-RXN is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0034481 name: chondroitin sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate." [EC:2.8.2.17, EC:2.8.2.5, GOC:mah] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0034482 name: chondroitin 2-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues." [PMID:17227754] synonym: "chondroitin 2-O-sulphotransferase activity" EXACT [] synonym: "chondroitin 2-sulfotransferase activity" EXACT [] is_a: GO:0034481 ! chondroitin sulfotransferase activity [Term] id: GO:0034483 name: heparan sulfate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate." [GOC:mah] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0034484 name: raffinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:16634, GOC:mah] synonym: "raffinose breakdown" EXACT [] synonym: "raffinose catabolism" EXACT [] synonym: "raffinose degradation" EXACT [] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:0033530 ! raffinose metabolic process [Term] id: GO:0034485 name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate." [GOC:pf] xref: MetaCyc:RXN-10036 is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity [Term] id: GO:0034486 name: vacuolar transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah] is_a: GO:0007034 ! vacuolar transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0034487 name: vacuolar amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah] synonym: "vacuolar amino acid transmembrane transport" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0034486 ! vacuolar transmembrane transport [Term] id: GO:0034488 name: basic amino acid export from vacuole namespace: biological_process def: "The directed movement of basic amino acids out of the vacuole." [GOC:mah] is_a: GO:0015802 ! basic amino acid transport is_a: GO:0032974 ! amino acid export from vacuole [Term] id: GO:0034489 name: neutral amino acid export from vacuole namespace: biological_process def: "The directed movement of neutral amino acids out of the vacuole." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0032974 ! amino acid export from vacuole [Term] id: GO:0034490 name: basic amino acid import into vacuole namespace: biological_process def: "The directed movement of basic amino acids into the vacuole." [GOC:mah] is_a: GO:0015802 ! basic amino acid transport is_a: GO:0032975 ! amino acid import into vacuole [Term] id: GO:0034491 name: neutral amino acid import into vacuole namespace: biological_process def: "The directed movement of neutral amino acids into the vacuole." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0032975 ! amino acid import into vacuole [Term] id: GO:0034492 name: hydrogenosome lumen namespace: cellular_component def: "The volume enclosed by the hydrogenosome membrane." [GOC:rph] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0042566 ! hydrogenosome [Term] id: GO:0034493 name: melanosome lumen namespace: cellular_component def: "The volume enclosed by the melanosome membrane." [GOC:rph] is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0042470 ! melanosome [Term] id: GO:0034494 name: microneme lumen namespace: cellular_component def: "The volume enclosed by the microneme membrane." [GOC:rph] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0020009 ! microneme [Term] id: GO:0034495 name: protein storage vacuole lumen namespace: cellular_component def: "The volume enclosed by the protein storage vacuole membrane." [GOC:rph] is_a: GO:0000330 ! plant-type vacuole lumen relationship: part_of GO:0000326 ! protein storage vacuole [Term] id: GO:0034496 name: multivesicular body membrane disassembly namespace: biological_process def: "The controlled breakdown of the membranes of multivesicular bodies." [GOC:rb] synonym: "MVB membrane disassembly" EXACT [] is_a: GO:0030397 ! membrane disassembly [Term] id: GO:0034497 name: protein localization to pre-autophagosomal structure namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS)." [GOC:rb] synonym: "protein localisation to pre-autophagosomal structure" EXACT [GOC:mah] synonym: "protein localization to PAS" EXACT [] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0034498 name: early endosome to Golgi transport namespace: biological_process def: "The directed movement of substances from early endosomes to the Golgi." [GOC:rb] synonym: "PGE to Golgi transport" EXACT [] synonym: "post-Golgi endosome to Golgi transport" EXACT [] is_a: GO:0042147 ! retrograde transport, endosome to Golgi is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0034499 name: late endosome to Golgi transport namespace: biological_process def: "The directed movement of substances from late endosomes to the Golgi." [GOC:rb] synonym: "prevacuolar endosome to Golgi transport" EXACT [] synonym: "PVE to Golgi transport" EXACT [] is_a: GO:0042147 ! retrograde transport, endosome to Golgi is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0034500 name: rDNA separation namespace: biological_process def: "The cell cycle process in which rDNA repeat regions are physically detached from each other during chromosome separation." [GOC:mah] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051304 ! chromosome separation [Term] id: GO:0034501 name: protein localization to kinetochore namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah] synonym: "condensin localization to kinetochore" NARROW [] synonym: "protein localisation to kinetochore" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome [Term] id: GO:0034502 name: protein localization to chromosome namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] synonym: "condensin localization to chromosome" NARROW [] synonym: "protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0034503 name: protein localization to nucleolar rDNA repeats namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus." [GOC:mah] synonym: "condensin localization to nucleolar rDNA repeats" NARROW [] synonym: "protein localisation to nucleolar rDNA repeats" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome [Term] id: GO:0034504 name: protein localization to nucleus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the nucleus." [GOC:ecd] synonym: "protein localisation to nucleus" EXACT [GOC:mah] synonym: "protein localization in cell nucleus" EXACT [] synonym: "protein localization in nucleus" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0034505 name: tooth mineralization namespace: biological_process def: "The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentine and cementum." [GOC:mah, MESH:tooth+calcification, MP:0002817] synonym: "tooth calcification" EXACT [] is_a: GO:0031214 ! biomineral tissue development relationship: part_of GO:0042476 ! odontogenesis [Term] id: GO:0034506 name: chromosome, centromeric core region namespace: cellular_component def: "The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw] synonym: "chromosome, centric core region" RELATED [] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0034507 name: chromosome, centromeric outer repeat region namespace: cellular_component def: "The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw] synonym: "chromosome, centric outer repeat region" RELATED [] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0034508 name: centromere complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw] synonym: "centromere assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051276 ! chromosome organization is_a: GO:0065004 ! protein-DNA complex assembly [Term] id: GO:0034509 name: centromeric core chromatin assembly namespace: biological_process def: "The assembly of chromatin into the specialized structure characteristic of the centromeric core region, defined by the presence of the variant histone CENP-A." [GOC:mah, GOC:vw] synonym: "centric core chromatin formation" RELATED [] synonym: "centromere loading" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "centromeric core chromatin assembly" EXACT [] is_a: GO:0031497 ! chromatin assembly relationship: part_of GO:0034508 ! centromere complex assembly [Term] id: GO:0034510 name: centromere separation namespace: biological_process def: "The cell cycle process in which centromeres are physically detached from each other during chromosome separation." [GOC:mah] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051304 ! chromosome separation [Term] id: GO:0034511 name: U3 snoRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with U3 small nucleolar RNA." [GOC:mah] is_a: GO:0030515 ! snoRNA binding [Term] id: GO:0034512 name: box C/D snoRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with box C/D small nucleolar RNA." [GOC:mah] is_a: GO:0030515 ! snoRNA binding [Term] id: GO:0034513 name: box H/ACA snoRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with box H/ACA small nucleolar RNA." [GOC:mah] is_a: GO:0030515 ! snoRNA binding [Term] id: GO:0034514 name: mitochondrial unfolded protein response namespace: biological_process def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins." [GOC:mah, PMID:17849004] synonym: "mtUPR" EXACT [] is_a: GO:0034620 ! cellular response to unfolded protein [Term] id: GO:0034515 name: proteasome storage granule namespace: cellular_component def: "A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:rb, PMID:18504300] synonym: "PSG" EXACT [] is_a: GO:0031597 ! cytosolic proteasome complex [Term] id: GO:0034516 name: response to vitamin B6 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah, GOC:rph] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0034517 name: ribophagy namespace: biological_process def: "The process in which cells degrade mature ribosomes under conditions of starvation." [PMID:18391941] is_a: GO:0006914 ! autophagy [Term] id: GO:0034518 name: RNA cap binding complex namespace: cellular_component def: "Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA." [GOC:mah] is_a: GO:0043234 ! protein complex [Term] id: GO:0034519 name: cytoplasmic RNA cap binding complex namespace: cellular_component def: "A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA." [PMID:16405910] is_a: GO:0034518 ! RNA cap binding complex [Term] id: GO:0034520 name: 2-naphthaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+." [UM-BBD_reactionID:r0772] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r0772 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034521 name: 1-naphthoic acid dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+." [UM-BBD_reactionID:r0773] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0773 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034522 name: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0774] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r0774 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034523 name: 3-formylsalicylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide." [UM-BBD_reactionID:r0777] xref: EC:1.2.3.- xref: UM-BBD_reactionID:r0777 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0034524 name: 2-hydroxyisophthalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2." [UM-BBD_reactionID:r0776] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0776 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034525 name: 1-naphthaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+." [UM-BBD_reactionID:r0787] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r0787 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034526 name: 2-methylnaphthalene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0788] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0788 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034527 name: 1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene." [UM-BBD_reactionID:r0790] xref: EC:1.13.-.- xref: UM-BBD_reactionID:r0790 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0034528 name: 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate." [UM-BBD_reactionID:r0791] xref: EC:5.3.99.- xref: UM-BBD_reactionID:r0791 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0034529 name: 2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate." [UM-BBD_reactionID:r0792] xref: EC:4.1.2.- xref: UM-BBD_reactionID:r0792 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0034530 name: 4-hydroxymethylsalicyaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+." [UM-BBD_reactionID:r0767] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r0767 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034531 name: 2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde." [UM-BBD_reactionID:r0766] xref: EC:4.1.2.- xref: UM-BBD_reactionID:r0766 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0034532 name: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate." [UM-BBD_reactionID:r0765] xref: EC:5.3.99.- xref: UM-BBD_reactionID:r0765 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0034533 name: 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate." [UM-BBD_reactionID:r0764] xref: EC:1.13.-.- xref: UM-BBD_reactionID:r0764 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0034534 name: 1-methylnaphthalene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0795] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0795 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034535 name: 1,2-dihydroxy-8-methylnaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+." [UM-BBD_reactionID:r0781] xref: EC:1.13.-.- xref: UM-BBD_reactionID:r0781 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0034536 name: 2-hydroxy-8-methylchromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate." [UM-BBD_reactionID:r0782] xref: EC:5.3.99.- xref: UM-BBD_reactionID:r0782 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0034537 name: 2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde." [UM-BBD_reactionID:r0783] xref: EC:4.1.2.- xref: UM-BBD_reactionID:r0783 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0034538 name: 3-methylsalicylaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+." [UM-BBD_reactionID:r0784] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r0784 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034539 name: 3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr." [UM-BBD_reactionID:r0821] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0821 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034540 name: 3-monobromobisphenol A reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr." [UM-BBD_reactionID:r0824] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0824 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034541 name: dimethylarsinite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH." [UM-BBD_reactionID:r0806] xref: EC:2.1.1.- xref: UM-BBD_reactionID:r0806 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0034542 name: trimethylarsine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O." [UM-BBD_reactionID:r0807] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0807 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034543 name: 5-aminosalicylate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate." [UM-BBD_reactionID:r0809] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0809 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034544 name: trans-ACOHDA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3." [UM-BBD_reactionID:r0810] xref: EC:3.5.99.- xref: UM-BBD_reactionID:r0810 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034545 name: fumarylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+." [UM-BBD_reactionID:r0811] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r0811 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034546 name: 2,4-dichloroaniline reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl." [UM-BBD_reactionID:r0819] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0819 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034547 name: N-cyclopropylmelamine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3." [UM-BBD_reactionID:r0825] xref: EC:3.5.4.- xref: MetaCyc:RXN-8018 xref: UM-BBD_reactionID:r0825 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0034548 name: N-cyclopropylammeline deaminase activity namespace: molecular_function def: "Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3." [UM-BBD_reactionID:r0826] xref: EC:3.5.4.- xref: MetaCyc:RXN-8019 xref: UM-BBD_reactionID:r0826 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0034549 name: N-cyclopropylammelide alkylamino hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid." [UM-BBD_reactionID:r0827] xref: EC:3.5.4.- xref: MetaCyc:RXN-8020 xref: UM-BBD_reactionID:r0827 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0034550 name: dimethylarsinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O." [UM-BBD_reactionID:r0838] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0838 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034551 name: mitochondrial respiratory chain complex III assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc] synonym: "mitochondrial cytochrome bc(1) complex assembly" EXACT [GOC:mcc] is_a: GO:0017062 ! respiratory chain complex III assembly is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly is_a: GO:0097033 ! mitochondrial respiratory chain complex III biogenesis [Term] id: GO:0034552 name: respiratory chain complex II assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II." [GOC:dgf] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0034553 name: mitochondrial respiratory chain complex II assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf] is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly is_a: GO:0034552 ! respiratory chain complex II assembly is_a: GO:0097032 ! mitochondrial respiratory chain complex II biogenesis [Term] id: GO:0034554 name: 3,3',5-tribromobisphenol A reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr." [UM-BBD_reactionID:r0842] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0842 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034555 name: 3,3'-dibromobisphenol A reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr." [UM-BBD_reactionID:r0844] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0844 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034556 name: nitrobenzoate nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+." [UM-BBD_reactionID:r0849] xref: EC:1.7.1.- xref: UM-BBD_reactionID:r0849 is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0034557 name: 2-hydroxylaminobenzoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O." [MetaCyc:RXN-8848] synonym: "o-hydroxylaminobenzoate nitroreductase activity" RELATED [UM-BBD_reactionID:r0850] xref: EC:1.4.-.- xref: MetaCyc:RXN-8848 xref: UM-BBD_reactionID:r0850 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0034558 name: technetium (VII) reductase activity namespace: molecular_function def: "Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-." [UM-BBD_reactionID:r0859] xref: EC:1.12.-.- xref: UM-BBD_reactionID:r0859 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0034559 name: bisphenol A hydroxylase B activity namespace: molecular_function def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0860] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0860 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034560 name: bisphenol A hydroxylase A activity namespace: molecular_function def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0861] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r0861 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034561 name: 1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O." [UM-BBD_reactionID:r0862] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r0862 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034562 name: 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O." [UM-BBD_reactionID:r0864] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0864 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034563 name: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0867] xref: EC:1.13.-.- xref: UM-BBD_reactionID:r0867 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034564 name: 4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0866] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r0866 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034565 name: 1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol." [UM-BBD_reactionID:r0872] xref: EC:3.5.99.- xref: UM-BBD_reactionID:r0872 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034567 name: chromate reductase activity namespace: molecular_function def: "Catalysis of the reaction: chromate = chromium (III)." [UM-BBD_reactionID:r0884] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0884 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034568 name: isoproturon dimethylaminedehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0892] xref: EC:1.5.99.- xref: UM-BBD_reactionID:r0892 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034569 name: monodemethylisoproturon dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0893] xref: EC:1.17.99.- xref: UM-BBD_reactionID:r0893 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0034570 name: hydroxymonomethylisoproturon dimethylaminedehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0894] xref: EC:1.5.99.- xref: UM-BBD_reactionID:r0894 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034571 name: 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid." [UM-BBD_reactionID:r0895] xref: EC:3.5.1.- xref: UM-BBD_reactionID:r0895 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034572 name: monodemethylisoproturon dimethylaminedehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-." [UM-BBD_reactionID:r0897] xref: EC:1.5.99.- xref: UM-BBD_reactionID:r0897 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034573 name: didemethylisoproturon amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline." [UM-BBD_reactionID:r0898] xref: EC:3.5.1.- xref: UM-BBD_reactionID:r0898 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034574 name: didemethylisoproturon dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0899] xref: EC:1.17.99.- xref: UM-BBD_reactionID:r0899 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0034575 name: 4-isopropylaniline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-." [UM-BBD_reactionID:r0901] xref: EC:1.17.99.- xref: UM-BBD_reactionID:r0901 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0034576 name: N-isopropylacetanilide amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate." [UM-BBD_reactionID:r0913] xref: EC:3.5.1.- xref: UM-BBD_reactionID:r0913 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034577 name: N-isopropylacetaniline monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone." [UM-BBD_reactionID:r0914] xref: EC:1.14.15.- xref: UM-BBD_reactionID:r0914 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034578 name: limonene 8-hydratase activity namespace: molecular_function def: "Catalysis of the reaction: limonene + H2O = alpha-terpineol." [UM-BBD_reactionID:r0916] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r0916 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034579 name: (1-methylpentyl)succinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate." [UM-BBD_reactionID:r0920] xref: EC:4.1.99.- xref: UM-BBD_reactionID:r0920 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0034580 name: 4-methyloctanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0924] xref: EC:1.3.99.- xref: UM-BBD_reactionID:r0924 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034581 name: 4-methyloct-2-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA." [UM-BBD_reactionID:r0925] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r0925 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034582 name: 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0926] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r0926 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034583 name: 21U-RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] is_a: GO:0003723 ! RNA binding [Term] id: GO:0034584 name: piRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] synonym: "Piwi-associated RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0034585 name: 21U-RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] synonym: "21U-RNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0034586 name: 21U-RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] synonym: "21U-RNA breakdown" EXACT [] synonym: "21U-RNA catabolism" EXACT [] synonym: "21U-RNA degradation" EXACT [] is_a: GO:0034585 ! 21U-RNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0034587 name: piRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] synonym: "piRNA metabolism" EXACT [] synonym: "Piwi-associated RNA metabolic process" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0034588 name: piRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] synonym: "piRNA breakdown" EXACT [] synonym: "piRNA catabolism" EXACT [] synonym: "piRNA degradation" EXACT [] synonym: "Piwi-associated RNA catabolic process" EXACT [] is_a: GO:0034587 ! piRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0034589 name: hydroxyproline transport namespace: biological_process def: "The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, PMID:14502423] synonym: "4-hydroxyproline transport" EXACT [] synonym: "L-hydroxyproline transport" NARROW [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0034590 name: L-hydroxyproline transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-hydroxyproline from one side of a membrane to the other." [GOC:mah, PMID:14502423] synonym: "4-hydroxyproline transmembrane transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0034591 name: rhoptry lumen namespace: cellular_component def: "The volume enclosed by the rhoptry membrane." [GOC:rph, PMID:17997128] is_a: GO:0043233 ! organelle lumen is_a: GO:0044464 ! cell part relationship: part_of GO:0020008 ! rhoptry [Term] id: GO:0034592 name: synaptic vesicle lumen namespace: cellular_component def: "The volume enclosed by the synaptic vesicle membrane." [GOC:rph] is_a: GO:0044456 ! synapse part is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0008021 ! synaptic vesicle [Term] id: GO:0034593 name: phosphatidylinositol bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the removal of one of the two phosphate groups of a phosphatidylinositol bisphosphate." [GOC:mah] synonym: "diphosphoinositide phosphatase activity" RELATED [] synonym: "phosphatidyl-inositol-bisphosphate phosphatase activity" EXACT [] synonym: "phosphatidylinositol-bisphosphatase activity" RELATED [] synonym: "triphosphoinositide phosphatase activity" RELATED [] synonym: "triphosphoinositide phosphomonoesterase activity" RELATED [] is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0034594 name: phosphatidylinositol trisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the removal of one of the three phosphate groups of a phosphatidylinositol trisphosphate." [GOC:mah] is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0034595 name: phosphatidylinositol phosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the removal the of the 5-phosphate group of a phosphatidylinositol phosphate." [GOC:elh] subset: gosubset_prok synonym: "phosphoinositide 5-phosphatase activity" EXACT [GOC:curators] synonym: "polyphosphoinositol lipid 5-phosphatase activity" EXACT [] is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0034596 name: phosphatidylinositol phosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the removal the of the 4-phosphate group of a phosphatidylinositol phosphate." [GOC:mah] synonym: "phosphoinositide 4-phosphatase activity" EXACT [GOC:curators] is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0034597 name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:mah] synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] synonym: "D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] xref: EC:3.1.3.66 xref: MetaCyc:3.1.3.66-RXN is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity is_a: GO:0042577 ! lipid phosphatase activity [Term] id: GO:0034598 name: phosphothreonine lyase activity namespace: molecular_function def: "Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product." [PMID:17303758, PMID:18084305] is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034599 name: cellular response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk] is_a: GO:0006979 ! response to oxidative stress is_a: GO:0033554 ! cellular response to stress is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0034601 name: oxoglutarate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H." [GOC:mah] xref: EC:1.2.1.- is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034602 name: oxoglutarate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH." [GOC:mah] xref: EC:1.2.1.- xref: KEGG:R08549 xref: MetaCyc:2OXOGLUTARATEDEH-RXN xref: Reactome:373878 "oxoglutarate dehydrogenase (NAD+) activity" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034603 name: pyruvate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [GOC:mah] xref: EC:1.2.1.- is_a: GO:0004738 ! pyruvate dehydrogenase activity is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034604 name: pyruvate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH." [GOC:mah] xref: EC:1.2.1.- xref: KEGG:R00209 xref: MetaCyc:PYRUVDEH-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034605 name: cellular response to heat namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] synonym: "cellular response to heat stress" EXACT [] is_a: GO:0009408 ! response to heat is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0034606 name: response to hermaphrodite contact namespace: biological_process def: "The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [PMID:18050467, WB_REF:WBPaper00002109] is_a: GO:0060179 ! male mating behavior [Term] id: GO:0034607 name: turning behavior involved in mating namespace: biological_process def: "The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [PMID:18050467, WB_REF:WBPaper00002109] synonym: "turning behavior during mating" EXACT [] is_a: GO:0035178 ! turning behavior is_a: GO:0060179 ! male mating behavior [Term] id: GO:0034608 name: vulval location namespace: biological_process def: "Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [PMID:18050467] is_a: GO:0060179 ! male mating behavior [Term] id: GO:0034609 name: spicule insertion namespace: biological_process def: "Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [PMID:18050467] is_a: GO:0060179 ! male mating behavior [Term] id: GO:0034610 name: oligodeoxyribonucleotidase activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates." [GOC:mah] synonym: "DNA oligonucleotidase activity" EXACT [] is_a: GO:0004536 ! deoxyribonuclease activity is_a: GO:0008946 ! oligonucleotidase activity [Term] id: GO:0034611 name: oligoribonucleotidase activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates." [GOC:mah] synonym: "RNA oligonucleotidase activity" EXACT [] is_a: GO:0004540 ! ribonuclease activity is_a: GO:0008946 ! oligonucleotidase activity [Term] id: GO:0034612 name: response to tumor necrosis factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] synonym: "response to TNF" EXACT [] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0034613 name: cellular protein localization namespace: biological_process alt_id: GO:0016249 def: "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular protein localisation" EXACT [GOC:mah] synonym: "channel localizer activity" NARROW [GOC:mah] is_a: GO:0008104 ! protein localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0034614 name: cellular response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] subset: gosubset_prok synonym: "cellular response to active oxygen species" EXACT [] synonym: "cellular response to AOS" EXACT [] synonym: "cellular response to reactive oxidative species" EXACT [] synonym: "cellular response to reactive oxygen intermediate" EXACT [] synonym: "cellular response to ROI" EXACT [] synonym: "cellular response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0034599 ! cellular response to oxidative stress [Term] id: GO:0034615 name: GCH1 complex namespace: cellular_component def: "A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive." [PMID:16696853] synonym: "GTP cyclohydrolase I complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0034616 name: response to laminar fluid shear stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls." [GOC:ecd] is_a: GO:0034405 ! response to fluid shear stress [Term] id: GO:0034617 name: tetrahydrobiopterin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions." [CHEBI:15372, GOC:BHF, GOC:mah, GOC:rl] synonym: "BH4 binding" EXACT [] synonym: "H4biopterin binding" EXACT [] synonym: "sapropterin binding" EXACT [] is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0034618 name: arginine binding namespace: molecular_function def: "Interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:BHF, GOC:rl] synonym: "aminopentanoic acid binding" RELATED [] synonym: "Arg binding" EXACT [] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0034619 name: cellular chaperone-mediated protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell, mediated by chaperone molecules that do not form part of the finished complex." [GOC:mah] subset: gosubset_prok synonym: "chaperone activity" RELATED [] is_a: GO:0051131 ! chaperone-mediated protein complex assembly [Term] id: GO:0034620 name: cellular response to unfolded protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER. subset: gosubset_prok synonym: "heat shock protein activity" RELATED [] is_a: GO:0006986 ! response to unfolded protein is_a: GO:0033554 ! cellular response to stress is_a: GO:0071216 ! cellular response to biotic stimulus is_a: GO:0071445 ! cellular response to protein stimulus [Term] id: GO:0034621 name: cellular macromolecular complex subunit organization namespace: biological_process def: "Any process carried out at the cellular level by which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex." [GOC:mah, GOC:mtg_mpo] subset: gosubset_prok synonym: "cellular macromolecular complex organization" EXACT [] synonym: "cellular macromolecular complex subunit organisation" EXACT [GOC:curators] is_a: GO:0043933 ! macromolecular complex subunit organization is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0034622 name: cellular macromolecular complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "cellular macromolecule complex assembly" EXACT [] is_a: GO:0034621 ! cellular macromolecular complex subunit organization is_a: GO:0065003 ! macromolecular complex assembly is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0034623 name: cellular macromolecular complex disassembly namespace: biological_process def: "The disaggregation of a macromolecular complex into its constituent components, carried out at the cellular level." [GOC:mah] subset: gosubset_prok synonym: "cellular macromolecule complex disassembly" EXACT [] is_a: GO:0032984 ! macromolecular complex disassembly is_a: GO:0034621 ! cellular macromolecular complex subunit organization is_a: GO:0071845 ! cellular component disassembly at cellular level [Term] id: GO:0034624 name: DNA recombinase assembly involved in gene conversion at mating-type locus namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA, involved in the conversion of the mating-type locus from one allele to another." [GOC:mah] is_a: GO:0000730 ! DNA recombinase assembly is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0034625 name: fatty acid elongation, monounsaturated fatty acid namespace: biological_process def: "Elongation of a fatty acid chain into which one C-C double bond has been introduced." [GOC:mah] subset: gosubset_prok is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid [Term] id: GO:0034626 name: fatty acid elongation, polyunsaturated fatty acid namespace: biological_process def: "Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced." [GOC:mah] subset: gosubset_prok is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid [Term] id: GO:0034627 name: de novo NAD biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk, PMID:17161604] is_a: GO:0009435 ! NAD biosynthetic process [Term] id: GO:0034628 name: de novo NAD biosynthetic process from aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk] is_a: GO:0019355 ! nicotinamide nucleotide biosynthetic process from aspartate is_a: GO:0034627 ! de novo NAD biosynthetic process [Term] id: GO:0034629 name: cellular protein complex localization namespace: biological_process def: "A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah] synonym: "cellular protein complex localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular protein complex localization" EXACT [] is_a: GO:0031503 ! protein complex localization is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0034630 name: RITS complex localization namespace: biological_process def: "Any process in which a RITS complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of RITS complex localization" EXACT [] synonym: "RITS complex localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization [Term] id: GO:0034631 name: microtubule anchoring at spindle pole body namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [GOC:mah, PMID:17486116] synonym: "attachment of spindle microtubules to SPB" EXACT [] synonym: "attachment of spindle microtubules to spindle pole body" EXACT [] synonym: "microtubule anchoring at SPB" EXACT [] is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center relationship: part_of GO:0007051 ! spindle organization [Term] id: GO:0034632 name: retinol transporter activity namespace: molecular_function def: "Enables the directed movement of retinol into, out of or within a cell, or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk] synonym: "vitamin A1 transporter activity" EXACT [] is_a: GO:0051183 ! vitamin transporter activity [Term] id: GO:0034633 name: retinol transport namespace: biological_process def: "The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk] synonym: "vitamin A1 transport" EXACT [] is_a: GO:0071938 ! vitamin A transport [Term] id: GO:0034634 name: glutathione transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of glutathione, the tripeptide glutamylcysteinylglycine, across a membrane into, out of or within a cell, or between cells." [GOC:mah] is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0034635 name: glutathione transport namespace: biological_process def: "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0042939 ! tripeptide transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0034636 name: strand invasion involved in gene conversion at mating-type locus namespace: biological_process def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA at the mating-type locus. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This process occurs as part of gene conversion at the mating-type locus." [GOC:mah] is_a: GO:0042148 ! strand invasion is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0034637 name: cellular carbohydrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah] is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0034638 name: phosphatidylcholine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:jp] subset: gosubset_prok synonym: "phosphatidylcholine breakdown" EXACT [] synonym: "phosphatidylcholine catabolism" EXACT [] synonym: "phosphatidylcholine degradation" EXACT [] is_a: GO:0046470 ! phosphatidylcholine metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0034639 name: L-amino acid efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane." [GOC:mah] synonym: "L-amino acid efflux permease activity" EXACT [] synonym: "L-amino acid export transporter activity" EXACT [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0034640 name: establishment of mitochondrion localization by microtubule attachment namespace: biological_process def: "The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization." [GOC:mah, PMID:12972644] synonym: "establishment of mitochondrion localisation by microtubule attachment" EXACT [GOC:mah] synonym: "mitochondrial localization by microtubule attachment" EXACT [] synonym: "mitochondrial migration by microtubule attachment" EXACT [] synonym: "mitochondrion migration by microtubule attachment" EXACT [] is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "cellular nitrogen compound metabolism" EXACT [] xref: Reactome:1252932 "Metabolism of amino acids and derivatives" xref: Reactome:1279866 "Metabolism of amino acids and derivatives" xref: Reactome:1298780 "Metabolism of amino acids and derivatives" xref: Reactome:1326435 "Metabolism of amino acids and derivatives" xref: Reactome:1352551 "Metabolism of amino acids and derivatives" xref: Reactome:1372778 "Metabolism of amino acids and derivatives" xref: Reactome:1392788 "Metabolism of amino acids and derivatives" xref: Reactome:1417265 "Metabolism of amino acids and derivatives" xref: Reactome:1450354 "Metabolism of amino acids and derivatives" xref: Reactome:1470893 "Metabolism of amino acids and derivatives" xref: Reactome:1482925 "Metabolism of amino acids and derivatives" xref: Reactome:1496721 "Metabolism of amino acids and derivatives" xref: Reactome:1514112 "Metabolism of amino acids and derivatives" xref: Reactome:1520932 "Metabolism of amino acids and derivatives" xref: Reactome:1526682 "Metabolism of amino acids and derivatives" xref: Reactome:1532411 "Metabolism of amino acids and derivatives" xref: Reactome:1535971 "Metabolism of amino acids and derivatives" xref: Reactome:1537976 "Metabolism of amino acids and derivatives" xref: Reactome:1539229 "Metabolism of amino acids and derivatives" xref: Reactome:1540288 "Metabolism of amino acids and derivatives" xref: Reactome:71291 "Metabolism of amino acids and derivatives" is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0034642 name: mitochondrion migration along actin filament namespace: biological_process def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220] synonym: "mitochondrial migration along actin filament" EXACT [GOC:dph, GOC:tb] synonym: "mitochondrial migration along microfilament" EXACT [] synonym: "mitochondrial migration, actin-mediated" EXACT [] synonym: "mitochondrion migration along microfilament" EXACT [] synonym: "mitochondrion transport along actin filament" EXACT [] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0051654 ! establishment of mitochondrion localization [Term] id: GO:0034643 name: establishment of mitochondrion localization, microtubule-mediated namespace: biological_process def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220] synonym: "establishment of mitochondrion localisation, microtubule-mediated" EXACT [GOC:mah] synonym: "microtubule-mediated mitochondrion localization" EXACT [] synonym: "mitochondrial localization, microtubule-mediated" EXACT [] is_a: GO:0007017 ! microtubule-based process is_a: GO:0051654 ! establishment of mitochondrion localization [Term] id: GO:0034644 name: cellular response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] subset: gosubset_prok synonym: "cellular response to ultraviolet light stimulus" EXACT [] synonym: "cellular response to ultraviolet radiation stimulus" EXACT [] synonym: "cellular response to UV light stimulus" EXACT [] synonym: "cellular response to UV radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV is_a: GO:0071482 ! cellular response to light stimulus [Term] id: GO:0034645 name: cellular macromolecule biosynthetic process namespace: biological_process alt_id: GO:0034961 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [CHEBI:33694, GOC:mah] synonym: "cellular biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule anabolism" EXACT [GOC:mah] synonym: "cellular macromolecule biosynthesis" EXACT [GOC:mah] synonym: "cellular macromolecule formation" EXACT [GOC:mah] synonym: "cellular macromolecule synthesis" EXACT [GOC:mah] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0034646 name: organelle-enclosing lipid monolayer namespace: cellular_component def: "A lipid monolayer that surrounds and encloses an organelle." [GOC:mah] is_a: GO:0044446 ! intracellular organelle part [Term] id: GO:0034647 name: histone demethylase activity (H3-trimethyl-K4 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896] synonym: "histone demethylase activity (H3-K4-me3 specific)" EXACT [] is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific) [Term] id: GO:0034648 name: histone demethylase activity (H3-dimethyl-K4 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896] synonym: "histone demethylase activity (H3-K4-me2 specific)" EXACT [] is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific) [Term] id: GO:0034649 name: histone demethylase activity (H3-monomethyl-K4 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 4) + O2 + FAD + H2O = histone H3 L-lysine (position 4) + H2O2 + formaldehyde + FADH2. This reaction is the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:16223729] synonym: "histone demethylase activity (H3-K4-me1 specific)" EXACT [] is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific) [Term] id: GO:0034650 name: cortisol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [CHEBI:17650, GOC:BHF, GOC:mah, GOC:rl] synonym: "cortisol metabolism" EXACT [] is_a: GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0034651 name: cortisol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [CHEBI:17650, GOC:BHF, GOC:mah, GOC:rl] synonym: "cortisol anabolism" NARROW [] synonym: "cortisol biosynthesis" EXACT [] synonym: "cortisol formation" EXACT [] synonym: "cortisol synthesis" EXACT [] is_a: GO:0006704 ! glucocorticoid biosynthetic process is_a: GO:0034650 ! cortisol metabolic process [Term] id: GO:0034652 name: extrachromosomal circular DNA localization involved in cell aging namespace: biological_process def: "A process in which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells contributing to their aging." [GOC:dph, GOC:jp, GOC:tb, PMID:18660802] comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. synonym: "extrachromosomal circular DNA localisation involved in cell aging" EXACT [GOC:mah] synonym: "extrachromosomal circular DNA localization during cell ageing" EXACT [] synonym: "extrachromosomal circular DNA localization during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging [Term] id: GO:0034653 name: retinoic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah] synonym: "retinoic acid breakdown" EXACT [] synonym: "retinoic acid catabolism" EXACT [] synonym: "retinoic acid degradation" EXACT [] synonym: "vitamin A1 acid catabolic process" EXACT [] is_a: GO:0042363 ! fat-soluble vitamin catabolic process is_a: GO:0042573 ! retinoic acid metabolic process [Term] id: GO:0034654 name: nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: gosubset_prok synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" EXACT [] is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0034655 name: nucleobase, nucleoside, nucleotide and nucleic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0034656 name: nucleobase, nucleoside and nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides." [GOC:mah] synonym: "nucleobase, nucleoside and nucleotide breakdown" EXACT [] synonym: "nucleobase, nucleoside and nucleotide catabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide degradation" EXACT [] is_a: GO:0034655 ! nucleobase, nucleoside, nucleotide and nucleic acid catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process [Term] id: GO:0034657 name: GID complex namespace: cellular_component def: "A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p." [PMID:12686616, PMID:18508925] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0034658 name: isopropylmalate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of isopropylmalate from one side of the membrane to the other." [GOC:mah] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0034659 name: isopropylmalate transport namespace: biological_process def: "The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0034660 name: ncRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs)." [GOC:mah] subset: gosubset_prok synonym: "ncRNA metabolism" EXACT [] xref: Reactome:1253461 "Metabolism of non-coding RNA" xref: Reactome:1280399 "Metabolism of non-coding RNA" xref: Reactome:1299236 "Metabolism of non-coding RNA" xref: Reactome:1326977 "Metabolism of non-coding RNA" xref: Reactome:1353072 "Metabolism of non-coding RNA" xref: Reactome:1373262 "Metabolism of non-coding RNA" xref: Reactome:1393281 "Metabolism of non-coding RNA" xref: Reactome:1417773 "Metabolism of non-coding RNA" xref: Reactome:1450873 "Metabolism of non-coding RNA" xref: Reactome:1471264 "Metabolism of non-coding RNA" xref: Reactome:194441 "Metabolism of non-coding RNA" is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0034661 name: ncRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:rb, PMID:18591258] synonym: "ncRNA breakdown" EXACT [] synonym: "ncRNA catabolism" EXACT [] synonym: "ncRNA degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0034662 name: CFTR-NHERF-ezrin complex namespace: cellular_component def: "A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity." [PMID:16129695, PMID:16798722, PMID:16926444] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0034663 name: endoplasmic reticulum chaperone complex namespace: cellular_component def: "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] synonym: "endoplasmic reticulum network complex" RELATED [] synonym: "ER chaperone complex" EXACT [] synonym: "ER network complex" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0034664 name: Ig heavy chain-bound endoplasmic reticulum chaperone complex namespace: cellular_component def: "A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] synonym: "Ig heavy chain-bound ER chaperone complex" EXACT [] synonym: "immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0034665 name: alpha1-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha1 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA1-ITGB1 complex" NARROW [] synonym: "VLA-1 complex" EXACT [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034666 name: alpha2-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha2 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA2-ITGB1 complex" NARROW [CORUM:2432] synonym: "VLA-2 complex" EXACT [PMID:3546305] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034667 name: alpha3-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha3 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA3-ITGB1 complex" NARROW [CORUM:2406] synonym: "VLA-3 complex" EXACT [PMID:3546305] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034668 name: alpha4-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha4 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA4-ITGB1 complex" NARROW [] synonym: "VLA-4 complex" EXACT [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034669 name: alpha4-beta7 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha4 subunit and one beta7 subunit." [PMID:12297042] synonym: "ITGA4-ITGB7 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034670 name: chemotaxis to arachidonic acid namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of arachidonic acid." [GOC:go_curators, PMID:18202452] is_a: GO:0006935 ! chemotaxis [Term] id: GO:0034671 name: retinoic acid receptor signaling pathway involved in pronephros anterior/posterior pattern specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros." [GOC:mh] synonym: "retinoic acid receptor signaling pathway involved in pronephric kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10] synonym: "retinoic acid receptor signalling pathway involved in pronephros anterior-posterior patterning" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway relationship: part_of GO:0034672 ! anterior/posterior pattern specification involved in pronephros development [Term] id: GO:0034672 name: anterior/posterior pattern specification involved in pronephros development namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mah] synonym: "anterior/posterior pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0009952 ! anterior/posterior pattern formation is_a: GO:0039017 ! pattern specification involved in pronephros development is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development [Term] id: GO:0034673 name: inhibin-betaglycan-ActRII complex namespace: cellular_component def: "A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B." [GOC:BHF, PMID:10746731] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0034674 name: alpha5-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha5 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA5-ITGB1 complex" NARROW [] synonym: "VLA-5 complex" EXACT [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034675 name: alpha6-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA6-ITGB1 complex" NARROW [CORUM:2413] synonym: "VLA-6 complex" EXACT [PMID:2649503] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034676 name: alpha6-beta4 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA6-ITGB4 complex" NARROW [CORUM:2323] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034677 name: alpha7-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha7 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA7-ITGB1 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034678 name: alpha8-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha8 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA8-ITGB1 complex" NARROW [CORUM:2439] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034679 name: alpha9-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha9 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA9-ITGB1 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034680 name: alpha10-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha10 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA10-ITGB1 complex" NARROW [CORUM:3057] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034681 name: alpha11-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alpha11 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA11-ITGB1 complex" NARROW [CORUM:3058] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034682 name: alphav-beta1 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGAV-ITGB1 complex" NARROW [CORUM:2436] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034683 name: alphav-beta3 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta3 subunit." [PMID:12297042] synonym: "ITGAV-ITGB3 complex" NARROW [CORUM:2816] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034684 name: alphav-beta5 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta5 subunit." [PMID:12297042] synonym: "ITGAV-ITGB5 complex" NARROW [CORUM:2350] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034685 name: alphav-beta6 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta6 subunit." [PMID:12297042] synonym: "ITGAV-ITGB6 complex" NARROW [CORUM:2354] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034686 name: alphav-beta8 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta8 subunit." [PMID:12297042] synonym: "ITGAV-ITGB8 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034687 name: alphaL-beta2 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphaL subunit and one beta2 subunit." [PMID:12297042] synonym: "Itgal-Itgb2 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034688 name: alphaM-beta2 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphaM subunit and one beta2 subunit." [PMID:12297042] synonym: "Itgam-Itgb2 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034689 name: alphaX-beta2 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphaX subunit and one beta2 subunit." [PMID:12297042] synonym: "Itgax-Itgb2 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034690 name: alphaD-beta2 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphaD subunit and one beta2 subunit." [PMID:12297042] synonym: "Itgad-Itgb2 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034691 name: alphaE-beta7 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphaE subunit and one beta7 subunit." [PMID:12297042] synonym: "Itgae-Itgb7 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034692 name: E.F.G complex namespace: cellular_component def: "A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex." [PMID:8641291] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0034693 name: U11/U12 snRNP namespace: cellular_component def: "A ribonucleoprotein complex formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077] synonym: "18S U11/U12 snRNP" NARROW [] synonym: "snRNP U11/U12" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0034694 name: response to prostaglandin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:BHF, GOC:vk] is_a: GO:0009725 ! response to hormone stimulus is_a: GO:0033993 ! response to lipid [Term] id: GO:0034695 name: response to prostaglandin E stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:BHF, GOC:vk] is_a: GO:0034694 ! response to prostaglandin stimulus [Term] id: GO:0034696 name: response to prostaglandin F stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:BHF, GOC:vk] is_a: GO:0034694 ! response to prostaglandin stimulus [Term] id: GO:0034697 name: response to prostaglandin I stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:BHF, GOC:vk] is_a: GO:0034694 ! response to prostaglandin stimulus [Term] id: GO:0034698 name: response to gonadotropin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:BHF, GOC:vk] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0034699 name: response to luteinizing hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:BHF, GOC:vk] is_a: GO:0034698 ! response to gonadotropin stimulus [Term] id: GO:0034700 name: allulose 6-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate." [GOC:imk] xref: MetaCyc:RXN0-304 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0034701 name: tripeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a tripeptide." [GOC:mah] xref: EC:3.4.13 xref: MetaCyc:3.4.11.4-RXN is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0034702 name: ion channel complex namespace: cellular_component def: "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:mah, ISBN:071673706X] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0016021 ! integral to membrane [Term] id: GO:0034703 name: cation channel complex namespace: cellular_component def: "An ion channel complex through which cations pass." [GOC:mah] is_a: GO:0034702 ! ion channel complex [Term] id: GO:0034704 name: calcium channel complex namespace: cellular_component def: "An ion channel complex through which calcium ions pass." [GOC:mah] is_a: GO:0034703 ! cation channel complex [Term] id: GO:0034705 name: potassium channel complex namespace: cellular_component def: "An ion channel complex through which potassium ions pass." [GOC:mah] is_a: GO:0034703 ! cation channel complex [Term] id: GO:0034706 name: sodium channel complex namespace: cellular_component def: "An ion channel complex through which sodium ions pass." [GOC:mah] is_a: GO:0034703 ! cation channel complex [Term] id: GO:0034707 name: chloride channel complex namespace: cellular_component def: "An ion channel complex through which chloride ions pass." [GOC:mah] is_a: GO:0034702 ! ion channel complex [Term] id: GO:0034708 name: methyltransferase complex namespace: cellular_component def: "A protein complex that possesses methyltransferase activity." [GOC:mah] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0034709 name: methylosome namespace: cellular_component def: "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452] synonym: "20S methylosome" EXACT [] synonym: "20S methyltransferase complex" EXACT [] is_a: GO:0034708 ! methyltransferase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034710 name: inhibin complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit." [GOC:BHF, GOC:mah] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0034711 name: inhibin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers." [GOC:BHF, GOC:mah] synonym: "inhibin monomer binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0034712 name: inhibin alpha binding namespace: molecular_function def: "Interacting selectively and non-covalently with inhibin alpha." [GOC:BHF, GOC:mah] is_a: GO:0034711 ! inhibin binding [Term] id: GO:0034713 name: type I transforming growth factor beta receptor binding namespace: molecular_function alt_id: GO:0005103 alt_id: GO:0005116 alt_id: GO:0005120 def: "Interacting selectively and non-covalently with a type I transforming growth factor beta receptor." [GOC:BHF, GOC:mah] synonym: "babo binding" NARROW [] synonym: "babo ligand" NARROW [] synonym: "baboon binding" NARROW [] synonym: "baboon ligand" NARROW [] synonym: "baboon receptor ligand" NARROW [] synonym: "sax binding" NARROW [] synonym: "sax ligand" NARROW [] synonym: "saxophone binding" NARROW [] synonym: "saxophone ligand" NARROW [] synonym: "TGF-beta type I binding" EXACT [] synonym: "thickveins binding" NARROW [] synonym: "thickveins ligand" NARROW [] synonym: "tkv binding" NARROW [] synonym: "tkv ligand" NARROW [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta receptor type I binding" EXACT [] synonym: "type I TGF-beta binding" EXACT [] is_a: GO:0005160 ! transforming growth factor beta receptor binding [Term] id: GO:0034714 name: type III transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type III transforming growth factor beta receptor." [GOC:BHF, GOC:mah] synonym: "betaglycan binding" RELATED [] synonym: "TGF-beta type III binding" EXACT [] synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED [] synonym: "transforming growth factor beta receptor type III binding" EXACT [] synonym: "type IIII TGF-beta binding" EXACT [] is_a: GO:0005160 ! transforming growth factor beta receptor binding [Term] id: GO:0034715 name: pICln-Sm protein complex namespace: cellular_component def: "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266] synonym: "6S pICln complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034716 name: Gemin3-Gemin4-Gemin5 complex namespace: cellular_component def: "A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly." [GOC:mah, PMID:17640873] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0034717 name: Gemin6-Gemin7-unrip complex namespace: cellular_component def: "A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly." [GOC:mah, PMID:17640873] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0034718 name: SMN-Gemin2 complex namespace: cellular_component def: "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0034719 name: SMN-Sm protein complex namespace: cellular_component def: "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [PMID:11522829, PMID:17401408] comment: Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797. synonym: "SMN-containing protein complex" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034720 name: histone H3-K4 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone." [GOC:mah] synonym: "H3K4 demethylation (me1 me2 and me3)" RELATED [] is_a: GO:0070076 ! histone lysine demethylation [Term] id: GO:0034721 name: histone H3-K4 demethylation, trimethyl-H3-K4-specific namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone." [GOC:mah] synonym: "H3K4 demethylation (me3)" EXACT [] synonym: "histone H3-K4 tridemethylation" RELATED [] is_a: GO:0034720 ! histone H3-K4 demethylation [Term] id: GO:0034722 name: gamma-glutamyl-peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26] subset: gosubset_prok synonym: "gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] xref: EC:3.4.19.9 xref: MetaCyc:3.4.19.9-RXN is_a: GO:0008242 ! omega peptidase activity [Term] id: GO:0034723 name: DNA replication-dependent nucleosome organization namespace: biological_process def: "The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629] synonym: "DNA replication-dependent nucleosome organisation" EXACT [GOC:curators] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0034724 name: DNA replication-independent nucleosome organization namespace: biological_process def: "The formation or destruction of chromatin structures, occurring outside the context of DNA replication." [GOC:mah, PMID:17510629] synonym: "DNA replication-independent nucleosome organisation" EXACT [GOC:curators] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0034725 name: DNA replication-dependent nucleosome disassembly namespace: biological_process def: "The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629] is_a: GO:0006337 ! nucleosome disassembly is_a: GO:0034723 ! DNA replication-dependent nucleosome organization [Term] id: GO:0034726 name: DNA replication-independent nucleosome disassembly namespace: biological_process def: "The controlled breakdown of nucleosomes outside the context of DNA replication." [GOC:mah, PMID:17510629] is_a: GO:0006337 ! nucleosome disassembly is_a: GO:0034724 ! DNA replication-independent nucleosome organization [Term] id: GO:0034727 name: piecemeal microautophagy of nucleus namespace: biological_process def: "Degradation of a cell nucleus by microautophagy." [GOC:jp, PMID:18701704] synonym: "PMN" EXACT [] is_a: GO:0016237 ! microautophagy [Term] id: GO:0034728 name: nucleosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes." [GOC:mah] synonym: "nucleosome organisation" EXACT [GOC:curators] is_a: GO:0006325 ! chromatin organization is_a: GO:0034621 ! cellular macromolecular complex subunit organization [Term] id: GO:0034729 name: histone H3-K79 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone." [GOC:se] synonym: "histone H3 K79 methylation" EXACT [] synonym: "histone H3K79me" EXACT [] synonym: "histone lysine H3 K79 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0034730 name: SmD-containing SMN-Sm protein complex namespace: cellular_component def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408] synonym: "SMN-containing protein complex" BROAD [] is_a: GO:0034719 ! SMN-Sm protein complex [Term] id: GO:0034731 name: Lsm-containing SMN-Sm protein complex namespace: cellular_component def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA." [PMID:12975319, PMID:17401408] synonym: "SMN-containing protein complex" BROAD [] is_a: GO:0034719 ! SMN-Sm protein complex [Term] id: GO:0034732 name: transcription factor TFIIIB-alpha complex namespace: cellular_component def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters." [PMID:11433012] is_a: GO:0000126 ! transcription factor TFIIIB complex [Term] id: GO:0034733 name: transcription factor TFIIIB-beta complex namespace: cellular_component def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters." [PMID:11433012] comment: Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans. is_a: GO:0000126 ! transcription factor TFIIIB complex [Term] id: GO:0034734 name: transcription factor TFIIIC1 complex namespace: cellular_component def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity." [GOC:mah, PMID:11433012, PMID:15096501] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0000127 ! transcription factor TFIIIC complex [Term] id: GO:0034735 name: transcription factor TFIIIC2 complex namespace: cellular_component def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter." [GOC:mah, PMID:11433012] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0000127 ! transcription factor TFIIIC complex [Term] id: GO:0034736 name: cholesterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA." [EC:2.3.1.26, RHEA:17732] synonym: "ACAT activity" BROAD [EC:2.3.1.26] synonym: "acyl coenzyme A-cholesterol-O-acyltransferase activity" EXACT [EC:2.3.1.26] synonym: "acyl-CoA:cholesterol acyltransferase activity" EXACT [EC:2.3.1.26] synonym: "acyl-CoA:cholesterol O-acyltransferase activity" EXACT [EC:2.3.1.26] synonym: "acylcoenzyme A:cholesterol O-acyltransferase activity" EXACT [] synonym: "cholesterol acyltransferase activity" BROAD [EC:2.3.1.26] synonym: "cholesterol ester synthetase activity" EXACT [EC:2.3.1.26] synonym: "cholesteryl ester synthetase activity" EXACT [EC:2.3.1.26] xref: EC:2.3.1.26 xref: KEGG:R01461 xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN xref: RHEA:17732 is_a: GO:0004772 ! sterol O-acyltransferase activity [Term] id: GO:0034737 name: ergosterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester." [GOC:mah] xref: EC:2.3.1.- is_a: GO:0004772 ! sterol O-acyltransferase activity [Term] id: GO:0034738 name: lanosterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester." [GOC:mah] xref: EC:2.3.1.- is_a: GO:0004772 ! sterol O-acyltransferase activity [Term] id: GO:0034739 name: histone deacetylase activity (H3-K16 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 16) + H2O = histone H3 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H3 protein." [EC:3.5.1.17, EC:3.5.1.98, RHEA:24551] xref: EC:3.5.1.98 is_a: GO:0004407 ! histone deacetylase activity [Term] id: GO:0034740 name: TFIIIC-TOP1-SUB1 complex namespace: cellular_component def: "A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III." [PMID:9660958] synonym: "TFIIIC-Topoisomerase 1-PC4 complex" EXACT [] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0034741 name: APC-tubulin-IQGAP1 complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization." [PMID:17126424] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "60S APC complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034742 name: APC-Axin-1-beta-catenin complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), Axin-1, and beta-catenin." [PMID:16188939] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "23S APC complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034743 name: APC-IQGAP complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0034744 name: APC-IQGAP1-Cdc42 complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0034745 name: APC-IQGAP1-Rac1 complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0034746 name: APC-IQGAP1-CLIP-170 complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0034747 name: Axin-APC-beta-catenin-GSK3B complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), Axin-1, beta-catenin, and glycogen synthase kinase 3 beta. Formation of this complex leads to phosphorylation of beta-catenin and down-regulation of beta-catenin activity." [PMID:9601641] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034748 name: Par3-APC-KIF3A complex namespace: cellular_component def: "A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity." [PMID:15556865] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034749 name: Scrib-APC complex namespace: cellular_component def: "A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation." [PMID:16611247] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "hScrib-APC complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034750 name: Scrib-APC-beta-catenin complex namespace: cellular_component def: "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "hScrib-APC-beta-catenin complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034751 name: aryl hydrocarbon receptor complex namespace: cellular_component def: "A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497] synonym: "AhR complex" EXACT [] synonym: "AHRC" EXACT [] is_a: GO:0043235 ! receptor complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0034752 name: cytosolic aryl hydrocarbon receptor complex namespace: cellular_component def: "An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP." [PMID:7598497, PMID:8937476, PMID:9447995] synonym: "9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex" RELATED [] synonym: "cytosolic AhR complex" EXACT [] synonym: "cytosolic AHRC" EXACT [] is_a: GO:0034751 ! aryl hydrocarbon receptor complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0034753 name: nuclear aryl hydrocarbon receptor complex namespace: cellular_component def: "An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT)." [PMID:7598497] synonym: "6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex" RELATED [] synonym: "nuclear AhR complex" EXACT [] synonym: "nuclear AHRC" EXACT [] is_a: GO:0034751 ! aryl hydrocarbon receptor complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0034754 name: cellular hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells." [GOC:mah] is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0034755 name: iron ion transmembrane transport namespace: biological_process def: "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] subset: gosubset_prok synonym: "transmembrane iron transport" EXACT [] is_a: GO:0006826 ! iron ion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0034756 name: regulation of iron ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of Fe transport" EXACT [] synonym: "regulation of iron transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport relationship: regulates GO:0006826 ! iron ion transport [Term] id: GO:0034757 name: negative regulation of iron ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of iron ion transport" EXACT [] synonym: "down-regulation of iron ion transport" EXACT [] synonym: "downregulation of iron ion transport" EXACT [] synonym: "inhibition of iron ion transport" NARROW [] synonym: "negative regulation of iron transport" EXACT [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:0043271 ! negative regulation of ion transport relationship: negatively_regulates GO:0006826 ! iron ion transport [Term] id: GO:0034758 name: positive regulation of iron ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of iron ion transport" NARROW [] synonym: "positive regulation of iron transport" EXACT [] synonym: "stimulation of iron ion transport" NARROW [] synonym: "up regulation of iron ion transport" EXACT [] synonym: "up-regulation of iron ion transport" EXACT [] synonym: "upregulation of iron ion transport" EXACT [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:0043270 ! positive regulation of ion transport relationship: positively_regulates GO:0006826 ! iron ion transport [Term] id: GO:0034759 name: regulation of iron ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of transmembrane Fe transport" EXACT [] synonym: "regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] synonym: "regulation of transmembrane iron transport" EXACT [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:0034765 ! regulation of ion transmembrane transport relationship: regulates GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0034760 name: negative regulation of iron ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of transmembrane iron ion transport" EXACT [] synonym: "down-regulation of transmembrane iron ion transport" EXACT [] synonym: "downregulation of transmembrane iron ion transport" EXACT [] synonym: "inhibition of transmembrane iron ion transport" NARROW [] synonym: "negative regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of transmembrane iron transport" EXACT [] is_a: GO:0034757 ! negative regulation of iron ion transport is_a: GO:0034759 ! regulation of iron ion transmembrane transport is_a: GO:0034766 ! negative regulation of ion transmembrane transport relationship: negatively_regulates GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0034761 name: positive regulation of iron ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of transmembrane iron ion transport" NARROW [] synonym: "positive regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of transmembrane iron transport" EXACT [] synonym: "stimulation of transmembrane iron ion transport" NARROW [] synonym: "up regulation of transmembrane iron ion transport" EXACT [] synonym: "up-regulation of transmembrane iron ion transport" EXACT [] synonym: "upregulation of transmembrane iron ion transport" EXACT [] is_a: GO:0034758 ! positive regulation of iron ion transport is_a: GO:0034759 ! regulation of iron ion transmembrane transport is_a: GO:0034767 ! positive regulation of ion transmembrane transport relationship: positively_regulates GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0034762 name: regulation of transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0055085 ! transmembrane transport [Term] id: GO:0034763 name: negative regulation of transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane transport" EXACT [] synonym: "down-regulation of transmembrane transport" EXACT [] synonym: "downregulation of transmembrane transport" EXACT [] synonym: "inhibition of transmembrane transport" NARROW [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0055085 ! transmembrane transport [Term] id: GO:0034764 name: positive regulation of transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane transport" NARROW [] synonym: "stimulation of transmembrane transport" NARROW [] synonym: "up regulation of transmembrane transport" EXACT [] synonym: "up-regulation of transmembrane transport" EXACT [] synonym: "upregulation of transmembrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0055085 ! transmembrane transport [Term] id: GO:0034765 name: regulation of ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0043269 ! regulation of ion transport relationship: regulates GO:0034220 ! ion transmembrane transport [Term] id: GO:0034766 name: negative regulation of ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane ion transport" EXACT [] synonym: "down-regulation of transmembrane ion transport" EXACT [] synonym: "downregulation of transmembrane ion transport" EXACT [] synonym: "inhibition of transmembrane ion transport" NARROW [] synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0043271 ! negative regulation of ion transport relationship: negatively_regulates GO:0034220 ! ion transmembrane transport [Term] id: GO:0034767 name: positive regulation of ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane ion transport" NARROW [] synonym: "positive regulation of transmembrane ion transport" EXACT [] synonym: "stimulation of transmembrane ion transport" NARROW [] synonym: "up regulation of transmembrane ion transport" EXACT [] synonym: "up-regulation of transmembrane ion transport" EXACT [] synonym: "upregulation of transmembrane ion transport" EXACT [] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0043270 ! positive regulation of ion transport relationship: positively_regulates GO:0034220 ! ion transmembrane transport [Term] id: GO:0034768 name: (E)-beta-ocimene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate." [PMID:12624761] xref: EC:4.2.3.- xref: MetaCyc:RXN-5109 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034769 name: basement membrane disassembly namespace: biological_process def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221] comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. is_a: GO:0022617 ! extracellular matrix disassembly is_a: GO:0071711 ! basement membrane organization [Term] id: GO:0034770 name: histone H4-K20 methylation namespace: biological_process def: "The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 methylation" EXACT [] synonym: "histone H4K20me" EXACT [] synonym: "histone lysine H4 K20 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0034771 name: histone H4-K20 monomethylation namespace: biological_process def: "The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 monomethylation" EXACT [] synonym: "histone lysine H4 K20 monomethylation" EXACT [] is_a: GO:0018026 ! peptidyl-lysine monomethylation is_a: GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0034772 name: histone H4-K20 dimethylation namespace: biological_process def: "The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 dimethylation" EXACT [] synonym: "histone lysine H4 K20 dimethylation" EXACT [] is_a: GO:0018027 ! peptidyl-lysine dimethylation is_a: GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0034773 name: histone H4-K20 trimethylation namespace: biological_process def: "The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 trimethylation" EXACT [] synonym: "histone lysine H4 K20 trimethylation" EXACT [] is_a: GO:0018023 ! peptidyl-lysine trimethylation is_a: GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0034774 name: secretory granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of a secretory granule." [GOC:rph] is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0030141 ! stored secretory granule [Term] id: GO:0034775 name: glutathione transmembrane transport namespace: biological_process def: "A process in which glutathione is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "transmembrane glutathione transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034635 ! glutathione transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0034776 name: response to histamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [CHEBI:18295, GOC:BHF, GOC:mah, GOC:vk] synonym: "response to histamine stimulus" EXACT [] is_a: GO:0014075 ! response to amine stimulus [Term] id: GO:0034777 name: recycling endosome lumen namespace: cellular_component def: "The volume enclosed by the membranes of a recycling endosome." [GOC:rph] is_a: GO:0031904 ! endosome lumen relationship: part_of GO:0055037 ! recycling endosome [Term] id: GO:0034778 name: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1003] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r1003 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034779 name: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA." [UM-BBD_reactionID:r1004] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r1004 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034780 name: glyphosate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-." [UM-BBD_reactionID:r0073] xref: EC:1.5.-.- xref: UM-BBD_reactionID:r0073 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034781 name: N-cyclohexylformamide amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate." [UM-BBD_reactionID:r1030] xref: EC:3.5.1.- xref: UM-BBD_reactionID:r1030 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034782 name: dimethylmalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2." [UM-BBD_reactionID:r1031] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r1031 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034783 name: pivalate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP." [UM-BBD_reactionID:r1032] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r1032 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034784 name: pivalyl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA." [UM-BBD_reactionID:r1033] xref: EC:5.4.99.- xref: UM-BBD_reactionID:r1033 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0034785 name: salicylate 5-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+." [UM-BBD_reactionID:r1034] xref: EC:1.14.13.- xref: MetaCyc:RXN-10446 xref: UM-BBD_reactionID:r1034 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034786 name: 9-fluorenone-3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone." [UM-BBD_reactionID:r1039] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1039 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034787 name: 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-." [UM-BBD_reactionID:r1040] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r1040 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034788 name: 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+." [UM-BBD_reactionID:r1041] xref: EC:1.13.-.- xref: UM-BBD_reactionID:r1041 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0034789 name: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+." [UM-BBD_reactionID:r1042] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r1042 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034790 name: 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1043] xref: EC:1.3.1.- xref: UM-BBD_reactionID:r1043 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034791 name: isobutylamine N-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine+ NADP+ + H2O." [UM-BBD_reactionID:r1053] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r1053 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034792 name: hypophosphite dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2." [UM-BBD_reactionID:r1058] xref: EC:1.14.11.- xref: UM-BBD_reactionID:r1058 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0034793 name: cyclopropanecarboxylate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-." [UM-BBD_reactionID:r1056] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r1056 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034794 name: cyclopropanecarboxyl-CoA decyclase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA." [UM-BBD_reactionID:r1057] xref: EC:5.5.1.- xref: UM-BBD_reactionID:r1057 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0034795 name: butane monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O." [UM-BBD_reactionID:r1059] xref: EC:1.14.15.- xref: UM-BBD_reactionID:r1059 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034796 name: adipate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-." [UM-BBD_reactionID:r1060] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r1060 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034797 name: fosfomycin 2-glutathione ligase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1073] xref: EC:6.2.-.- xref: UM-BBD_reactionID:r1073 is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0034798 name: fosfomycin 2-L-cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1- L-cysteine-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1074] xref: EC:6.2.-.- xref: UM-BBD_reactionID:r1074 is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0034799 name: dihydride TNP tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)." [UM-BBD_reactionID:r1070] xref: EC:5.3.2.- xref: UM-BBD_reactionID:r1070 is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0034800 name: TNP dihydride denitratase activity namespace: molecular_function def: "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = 2,4-DNP hydride Meisenheimer complex + NO2." [UM-BBD_reactionID:r1067] xref: EC:1.7.99.- xref: UM-BBD_reactionID:r1067 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0034801 name: 2,4-dinitrocyclohexanone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate." [UM-BBD_reactionID:r1069] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r1069 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034802 name: branched-chain dodecylbenzene sulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite." [UM-BBD_reactionID:r1079] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r1079 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034803 name: 3-hydroxy-2-naphthoate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate." [UM-BBD_reactionID:r1104] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1104 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034804 name: benzo(a)pyrene 11,12-epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide." [UM-BBD_reactionID:r1119] xref: EC:1.14.99.- xref: UM-BBD_reactionID:r1119 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034805 name: benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1121] xref: EC:1.3.1.- xref: UM-BBD_reactionID:r1121 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034806 name: benzo(a)pyrene 11,12-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol." [UM-BBD_reactionID:r1124] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1124 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034807 name: 4,5-dihydroxybenzo(a)pyrene methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene." [UM-BBD_reactionID:r1131] xref: EC:2.1.1.- xref: UM-BBD_reactionID:r1131 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0034808 name: benzo(a)pyrene 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol." [UM-BBD_reactionID:r1126] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1126 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034809 name: benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2." [UM-BBD_reactionID:r1127] xref: EC:1.3.1.- xref: UM-BBD_reactionID:r1127 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034810 name: 4,5-dihydroxybenzo(a)pyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate." [UM-BBD_reactionID:r1128] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1128 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034811 name: benzo(a)pyrene 9,10-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol." [UM-BBD_reactionID:r1132] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1132 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034812 name: 9,10-dihydroxybenzo(a)pyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1134] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1134 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034813 name: benzo(a)pyrene 7,8-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol." [UM-BBD_reactionID:1137] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1137 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034814 name: 7,8-dihydroxy benzo(a)pyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1138] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1138 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034815 name: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+." [UM-BBD_reactionID:r1135] xref: EC:4.1.3.- xref: UM-BBD_reactionID:r1135 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0034816 name: anthracene 9,10-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol." [UM-BBD_reactionID:r1141] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1141 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034817 name: cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-." [UM-BBD_reactionID:r1144] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r1144 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034818 name: ADD 9alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin." [UM-BBD_reactionID:r1149] xref: EC:1.14.15.- xref: UM-BBD_reactionID:r1149 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034819 name: 3-HSA hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O." [UM-BBD_reactionID:r1150] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r1150 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034820 name: 4,9-DSHA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+." [UM-BBD_reactionID:r1152] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r1152 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034821 name: citronellol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+." [UM-BBD_reactionID:r1155] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r1155 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034822 name: citronellal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+." [UM-BBD_reactionID:r1156] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r1156 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034823 name: citronellyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1157] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r1157 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034824 name: citronellyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: citronellyl-CoA + NAH+ = cis-geranyl-CoA + NADH + H+." [UM-BBD_reactionID:r1159] xref: EC:1.3.1.- xref: UM-BBD_reactionID:r1159 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034825 name: tetralin ring-hydroxylating dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+." [UM-BBD_reactionID:r1169] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r1169 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034826 name: 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+." [UM-BBD_reactionID:r1170] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r1170 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034827 name: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+." [UM-BBD_reactionID:r1171] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1171 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034828 name: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+." [UM-BBD_reactionID:r1172] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r1172 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034829 name: 2-hydroxydec-2,4-diene-1,10-dioate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate." [UM-BBD_reactionID:r1172] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r1172 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034830 name: (2Z)-2,4-dihydroxydec-2-enedioate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate." [UM-BBD_reactionID:r1174] xref: EC:4.1.3.- xref: UM-BBD_reactionID:r1174 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0034831 name: (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1176] xref: EC:1.1.1.- xref: UM-BBD_reactionID:r1176 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0034832 name: geranial dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+." [UM-BBD_reactionID:r1164] xref: EC:1.2.1.- xref: UM-BBD_reactionID:r1164 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034833 name: geranylate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-." [UM-BBD_reactionID:r1165] xref: EC:2.8.3.- xref: UM-BBD_reactionID:r1165 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0034834 name: 2-mercaptobenzothiazole dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol." [UM-BBD_reactionID:r1177] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1177 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034835 name: 2-mercaptobenzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1178] xref: EC:1.13.12.- xref: UM-BBD_reactionID:r1178 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0034836 name: 6-hydroxy-2-mercaptobenzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1181] xref: EC:1.13.12.- xref: UM-BBD_reactionID:r1181 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0034837 name: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-." [UM-BBD_reactionID:r1179] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r1179 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034838 name: menthone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+." [UM-BBD_reactionID:r1183] xref: EC:1.3.1.- xref: UM-BBD_reactionID:r1183 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034839 name: menth-2-enone hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone." [UM-BBD_reactionID:r1184] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r1184 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034840 name: 3-hydroxymenthone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+." [UM-BBD_reactionID:r1185] xref: EC:1.1.1.- xref: UM-BBD_reactionID:r1185 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0034841 name: mentha-1,3-dione-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA." [UM-BBD_reactionID:r1186] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r1186 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034842 name: thiophene-2-carboxylate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1234] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r1234 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034843 name: 2-oxoglutaryl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH." [UM-BBD_reactionID:r1238] xref: EC:3.1.2.- xref: UM-BBD_reactionID:r1238 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0034844 name: naphthyl-2-methyl-succinate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate." [UM-BBD_reactionID:r1256] xref: EC:2.8.3.- xref: UM-BBD_reactionID:r1256 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0034845 name: naphthyl-2-methyl-succinyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1258] xref: EC:1.3.99.- xref: UM-BBD_reactionID:r1258 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034846 name: naphthyl-2-methylene-succinyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA." [UM-BBD_reactionID:r1259] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r1259 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034847 name: naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1260] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r1260 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034848 name: naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA." [UM-BBD_reactionID:r1261] xref: EC:2.3.1.- xref: UM-BBD_reactionID:r1261 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034849 name: 2-naphthoate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH." [UM-BBD_reactionID:r1262] xref: EC:2.8.3.- xref: UM-BBD_reactionID:r1262 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0034850 name: isooctane monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol." [UM-BBD_reactionID:r1269] xref: EC:1.13.12.- xref: UM-BBD_reactionID:r1269 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0034851 name: 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r1274] xref: EC:2.3.1.- xref: UM-BBD_reactionID:r1274 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034852 name: 4,4-dimethyl-3-oxopentanal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1309] xref: EC:1.2.-.- xref: UM-BBD_reactionID:r1309 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0034853 name: 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2." [UM-BBD_reactionID:r1278] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r1278 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034854 name: 4,4-dimethyl-3-oxopentanoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2." [UM-BBD_reactionID:r1280] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r1280 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034855 name: 4-AD 9alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O." [UM-BBD_reactionID:r1153] xref: EC:1.14.15.- xref: UM-BBD_reactionID:r1153 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034856 name: 2-hydroxyhexa-2,4-dienoate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate." [UM-BBD_reactionID:r1281] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r1281 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034857 name: 2-(methylthio)benzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole." [UM-BBD_reactionID:r1287] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1287 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034858 name: 2-hydroxybenzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole." [UM-BBD_reactionID:r1291] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1291 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034859 name: benzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole." [UM-BBD_reactionID:r1292] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1292 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034860 name: 2-mercaptobenzothiazole desulfurase activity namespace: molecular_function def: "Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor." [UM-BBD_reactionID:r1288] xref: EC:4.4.1.- xref: UM-BBD_reactionID:r1288 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0034861 name: benzothiazole-2-sulfonate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-." [UM-BBD_reactionID:r1290] xref: EC:3.13.1.- xref: UM-BBD_reactionID:r1290 is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds [Term] id: GO:0034862 name: 2,6-dihydroxybenzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole." [UM-BBD_reactionID:r1294] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1294 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034863 name: 2,4,4-trimethyl-1-pentanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1270] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r1270 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034864 name: 2,4,4-trimethylpentanal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1275] xref: EC:1.2.-.- xref: UM-BBD_reactionID:r1275 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0034865 name: 2,4,4-trimethylpentanoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-." [UM-BBD_reactionID:r1271] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r1271 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034866 name: 2,4,4-trimethylpentanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1276] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r1276 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034867 name: 2,4,4-trimethylpent-2-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA." [UM-BBD_reactionID:r1277] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r1277 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034868 name: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1273] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r1273 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034869 name: 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH." [UM-BBD_reactionID:r1307] xref: EC:3.1.2.- xref: UM-BBD_reactionID:r1307 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0034870 name: pinacolone 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one." [UM-BBD_reactionID:r12979] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r12979 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034871 name: 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1308] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r1308 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034872 name: trans-geranyl-CoA isomerase activity namespace: molecular_function def: "Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA." [UM-BBD_reactionID:r1310] xref: EC:5.2.1.- xref: UM-BBD_reactionID:r1310 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0034873 name: thioacetamide S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O." [UM-BBD_reactionID:r1312] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1312 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034874 name: thioacetamide S-oxide S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O." [UM-BBD_reactionID:r1313] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1313 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034875 name: caffeine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O." [UM-BBD_reactionID:r1321] xref: EC:1.17.5.- xref: UM-BBD_reactionID:r1321 is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [Term] id: GO:0034876 name: isonicotinic acid hydrazide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine." [UM-BBD_reactionID:r1336] xref: EC:3.5.1.- xref: UM-BBD_reactionID:r1336 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034877 name: isonicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor." [UM-BBD_reactionID:r1337] xref: EC:1.15.-.- xref: UM-BBD_reactionID:r1337 is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0034878 name: 2-hydroxyisonicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor." [UM-BBD_reactionID:r1338] xref: EC:1.15.-.- xref: UM-BBD_reactionID:r1338 is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0034879 name: 2,3,6-trihydroxyisonicotinate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2." [UM-BBD_reactionID:r1340] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r1340 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034880 name: citrazinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1339] xref: EC:1.15.-.- xref: UM-BBD_reactionID:r1339 is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0034881 name: citrazinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: citrazinate + H2O = cis-aconitamide." [UM-BBD_reactionID:r1343] xref: EC:3.5.2.- xref: UM-BBD_reactionID:r1343 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0034882 name: cis-aconitamide amidase activity namespace: molecular_function def: "Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3." [UM-BBD_reactionID:r1344] xref: EC:3.5.1.- xref: UM-BBD_reactionID:r1344 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034883 name: isonicotinate reductase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: isonicotinate + 2 H+ + 2 e- = 1,4-dihydroisonicotinate." [UM-BBD_reactionID:r1347] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. xref: EC:1.3.-.- xref: UM-BBD_enzymeID:e0841 is_obsolete: true consider: GO:0016627 [Term] id: GO:0034884 name: gamma-N-formylaminovinylacetaldehyde dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: gamma-N-formylaminovinylacetaldehyde + H2O = gamma-N-formylaminovinylacetate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1349] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. xref: EC:1.2.99.- xref: UM-BBD_enzymeID:e0842 is_obsolete: true consider: GO:0016903 [Term] id: GO:0034885 name: gamma-N-formylaminovinylacetate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH." [UM-BBD_reactionID:r1350] xref: EC:3.5.1.- xref: UM-BBD_reactionID:r1350 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034886 name: gamma-aminovinylacetate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3." [UM-BBD_reactionID:r1351] xref: EC:3.5.99.- xref: UM-BBD_reactionID:r1351 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034887 name: 1,4-dihydroisonicotinate 2,3-dioxygenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 1,4-dihydroisonicotinate + O2 = gamma-N-formylaminovinylacetaldehyde + CO2." [UM-BBD_reactionID:r1348] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. xref: EC:1.13.11.- xref: UM-BBD_enzymeID:e0845 is_obsolete: true consider: GO:0016702 [Term] id: GO:0034888 name: endosulfan monooxygenase I activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O." [UM-BBD_reactionID:r1382] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1382 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034889 name: endosulfan hemisulfate sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate." [UM-BBD_reactionID:r1384] xref: EC:3.1.6.- xref: UM-BBD_reactionID:r1384 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0034890 name: endosulfan diol hydrolyase (cyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O." [UM-BBD_reactionID:r1386] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r1386 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034891 name: endosulfan diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-." [UM-BBD_reactionID:r1388] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r1388 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034892 name: endosulfan lactone lactonase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+." [UM-BBD_reactionID:r1389] xref: EC:3.1.1.- xref: UM-BBD_reactionID:r1389 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0034893 name: N-nitrodimethylamine hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O." [UM-BBD_reactionID:r1395] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1395 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034894 name: 4-hydroxypyridine-3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+." [UM-BBD_reactionID:r1397] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r1397 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034895 name: pyridine-3,4-diol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate." [UM-BBD_reactionID:r1398] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1398 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034896 name: 3-formiminopyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3." [UM-BBD_reactionID:r1400] xref: EC:3.5.99.- xref: UM-BBD_reactionID:r1400 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034897 name: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol." [UM-BBD_reactionID:r1358] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1358 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034898 name: hexadecyltrimethylammonium chloride monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O." [UM-BBD_reactionID:r1373] xref: EC:1.13.12.- xref: UM-BBD_reactionID:r1373 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0034899 name: trimethylamine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + NADH + H+ + O2 = trimethylamine N-oxide + NAD+ + H2O." [UM-BBD_reactionID:r1407] xref: EC:1.14.13.- xref: UM-BBD_reactionID:r1407 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034900 name: 3-(N-formyl)-formiminopyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate." [UM-BBD_reactionID:r1399] xref: EC:3.5.99.- xref: UM-BBD_reactionID:r1399 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034901 name: endosulfan hydroxyether dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1411] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r1411 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034902 name: endosulfan sulfate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite." [UM-BBD_reactionID:r1387] xref: EC:3.1.6.- xref: UM-BBD_reactionID:r1387 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0034903 name: endosulfan ether monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O." [UM-BBD_reactionID:r1413] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1413 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034904 name: 5-chloro-2-oxopent-4-enoate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate." [UM-BBD_reactionID:r1436] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r1436 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034905 name: 5-chloro-4-hydroxy-2-oxopentanate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde." [UM-BBD_reactionID:r1437] xref: EC:4.1.3.- xref: UM-BBD_reactionID:r1437 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0034906 name: N-isopropylaniline 1,2-dixoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine." [UM-BBD_reactionID:r0721] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0721 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034907 name: acetanilide 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide." [UM-BBD_reactionID:r0723] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0723 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034908 name: 2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+." [UM-BBD_reactionID:r0724] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r0724 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034909 name: 6-hydroxypseudooxynicotine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine." [UM-BBD_reactionID:r1441] xref: EC:1.5.-.- xref: UM-BBD_reactionID:r1441 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034910 name: 6-hydroxy-3-succinoylpyridine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine." [UM-BBD_reactionID:r1442] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r1442 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034911 name: phthalate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+." [UM-BBD_reactionID:r1444] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r1444 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034912 name: phthalate 3,4-cis-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+." [UM-BBD_reactionID:r1445] xref: EC:1.3.1.- xref: MetaCyc:RXN5F9-56 xref: UM-BBD_reactionID:r1445 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034914 name: TNP hydride denitratase activity namespace: molecular_function def: "Catalysis of the reaction: TNP hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite." [UM-BBD_reactionID:r1448] xref: EC:1.7.99.- xref: UM-BBD_reactionID:r1448 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0034915 name: 2-methylhexanoyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0927] xref: EC:2.3.1.- xref: UM-BBD_reactionID:r0927 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034916 name: 2-methylhexanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-." [UM-BBD_reactionID:r0928] xref: EC:1.3.99.- xref: UM-BBD_reactionID:r0928 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034917 name: 2-methylhex-2-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0929] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r0929 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034918 name: 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0930] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r0930 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034919 name: butyryl-CoA 2-C-propionyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA." [UM-BBD_reactionID:r0931] xref: EC:2.3.1.- xref: UM-BBD_reactionID:r0931 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034920 name: pyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0934] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0934 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034921 name: cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0935] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r0935 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034922 name: 4,5-dihydroxypyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+." [UM-BBD_reactionID:r0936] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0936 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034923 name: phenanthrene-4,5-dicarboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2." [UM-BBD_reactionID:r0937] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0937 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034924 name: cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2." [UM-BBD_reactionID:r0940] xref: EC:1.3.-.- xref: UM-BBD_reactionID:r0940 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034925 name: pyrene 4,5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O." [UM-BBD_reactionID:r0941] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0941 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034926 name: pyrene-4,5-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0942] xref: EC:3.3.2.- xref: UM-BBD_reactionID:r0942 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0034927 name: pyrene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O." [UM-BBD_reactionID:r0943] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0943 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034928 name: 1-hydroxypyrene 6,7-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0946] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0946 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034929 name: 1-hydroxypyrene 7,8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O." [UM-BBD_reactionID:r0949] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r0949 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034930 name: 1-hydroxypyrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX." [UM-BBD_reactionID:r0952] xref: EC:2.8.2.- xref: UM-BBD_reactionID:r0952 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0034931 name: 1-hydroxypyrene methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX." [UM-BBD_reactionID:r0953] xref: EC:2.1.1.- xref: UM-BBD_reactionID:r0953 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0034932 name: 1-methoxypyrene 6,7-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0954] xref: EC:1.4.-.- xref: UM-BBD_reactionID:r0954 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0034933 name: 1-hydroxy-6-methoxypyrene methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX." [UM-BBD_reactionID:r0956] xref: EC:2.1.1.- xref: UM-BBD_reactionID:r0956 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0034934 name: phenanthrene-4-carboxylate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate." [UM-BBD_reactionID:r0939] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0939 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034935 name: tetrachlorobenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+." [UM-BBD_reactionID:r0957] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0957 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034936 name: 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+." [UM-BBD_reactionID:r0959] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r0959 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034937 name: perchlorate reductase activity namespace: molecular_function def: "Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O." [UM-BBD_reactionID:r0980] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r0980 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034938 name: pyrrole-2-carboxylate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O." [UM-BBD_reactionID:r0968] xref: EC:1.14.14.- xref: UM-BBD_reactionID:r0968 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034939 name: 5-hydroxypyrrole-2-carboxylate tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate." [UM-BBD_reactionID:r0969] xref: EC:5.3.2.- xref: UM-BBD_reactionID:r0969 is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0034940 name: 5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3." [UM-BBD_reactionID:r0984] xref: EC:3.5.2.- xref: UM-BBD_reactionID:r0984 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0034941 name: pyrrole-2-carboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2." [UM-BBD_reactionID:r0970] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0970 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034942 name: cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0988] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r0988 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034943 name: trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0989] xref: EC:6.2.1.- xref: UM-BBD_reactionID:r0989 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034944 name: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+." [UM-BBD_reactionID:r0986] xref: EC:1.1.-.- xref: UM-BBD_reactionID:r0986 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034945 name: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r0987] xref: EC:2.3.1.- xref: UM-BBD_reactionID:r0987 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034946 name: 3-isopropylbut-3-enoyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH." [UM-BBD_reactionID:r0994] xref: EC:3.1.2.- xref: UM-BBD_reactionID:r0994 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0034947 name: terephthalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-." [UM-BBD_reactionID:r0321] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0321 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034948 name: 2,6-dihydroxypseudooxynicotine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate." [UM-BBD_reactionID:r0482] xref: EC:3.7.1.- xref: UM-BBD_reactionID:r0482 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034949 name: 1,1-dichloroethane reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl." [UM-BBD_reactionID:r1008] xref: EC:1.97.1.- xref: UM-BBD_reactionID:r1008 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034950 name: phenylboronic acid monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3." [UM-BBD_reactionID:r1020] xref: EC:1.14.-.- xref: UM-BBD_reactionID:r1020 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034951 name: o-hydroxylaminobenzoate mutase activity namespace: molecular_function def: "Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate." [UM-BBD_reactionID:r1026] xref: EC:5.4.99.- xref: MetaCyc:RXN-8846 xref: UM-BBD_reactionID:r1026 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0034952 name: malonate semialdehyde decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2." [UM-BBD_reactionID:r0266] xref: EC:4.1.1.- xref: UM-BBD_reactionID:r0266 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034953 name: perillyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r1002] xref: EC:4.2.1.- xref: UM-BBD_reactionID:r1002 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034954 name: diphenyl ether 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether." [UM-BBD_reactionID:r1450] xref: EC:1.14.12.- xref: UM-BBD_reactionID:r1450 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034955 name: 2,3-dihydroxydiphenyl ether dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol." [UM-BBD_reactionID:r1451] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1451 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034956 name: diphenyl ether 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+." [UM-BBD_reactionID:r1453] xref: EC:1.13.11.- xref: UM-BBD_reactionID:r1453 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034957 name: 3-nitrophenol nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O." [UM-BBD_reactionID:r1495] xref: EC:1.7.1.- xref: UM-BBD_reactionID:r1495 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0034958 name: aminohydroquinone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3." [UM-BBD_reactionID:r1497] xref: EC:3.5.99.- xref: UM-BBD_reactionID:r1497 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034959 name: endothelin maturation namespace: biological_process def: "The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin." [GOC:BHF, GOC:rl] is_a: GO:0016486 ! peptide hormone processing relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood [Term] id: GO:0034963 name: box C/D snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript into a mature box C/D snoRNA." [GOC:mah] is_a: GO:0033967 ! box C/D snoRNA metabolic process is_a: GO:0043144 ! snoRNA processing [Term] id: GO:0034964 name: box H/ACA snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript into a mature box H/ACA snoRNA." [GOC:mah] is_a: GO:0033979 ! box H/ACA snoRNA metabolic process is_a: GO:0043144 ! snoRNA processing [Term] id: GO:0034965 name: intronic box C/D snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA." [GOC:mah] is_a: GO:0031070 ! intronic snoRNA processing is_a: GO:0034963 ! box C/D snoRNA processing [Term] id: GO:0034966 name: intronic box H/ACA snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA." [GOC:mah] is_a: GO:0031070 ! intronic snoRNA processing is_a: GO:0034964 ! box H/ACA snoRNA processing [Term] id: GO:0034967 name: Set3 complex namespace: cellular_component def: "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p." [GOC:ds, PMID:11711434] synonym: "HDAC3 complex" EXACT [] synonym: "SET3C" EXACT [] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0034968 name: histone lysine methylation namespace: biological_process def: "The modification of a histone by addition of a methyl group to a lysine residue." [GOC:mah] is_a: GO:0016571 ! histone methylation [Term] id: GO:0034969 name: histone arginine methylation namespace: biological_process def: "The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah] is_a: GO:0016571 ! histone methylation [Term] id: GO:0034970 name: histone H3-R2 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone." [GOC:mah] synonym: "histone H3 R2 methylation" EXACT [] synonym: "histone H3R2me" EXACT [] synonym: "histone lysine H3 R2 methylation" EXACT [] is_a: GO:0034969 ! histone arginine methylation [Term] id: GO:0034971 name: histone H3-R17 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone." [GOC:mah] synonym: "histone H3 R17 methylation" EXACT [] synonym: "histone H3R17me" EXACT [] synonym: "histone lysine H3 R17 methylation" EXACT [] is_a: GO:0034969 ! histone arginine methylation [Term] id: GO:0034972 name: histone H3-R26 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah] synonym: "histone H3 R26 methylation" EXACT [] synonym: "histone H3R26me" EXACT [] synonym: "histone lysine H3 R26 methylation" EXACT [] is_a: GO:0034969 ! histone arginine methylation [Term] id: GO:0034973 name: Sid2-Mob1 complex namespace: cellular_component def: "A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex." [GOC:vw, PMID:10837231, PMID:15060149] synonym: "Dbf2p-Mob1p complex" EXACT [] synonym: "Sid2-Mob1 kinase complex" EXACT [] synonym: "Sid2p-Mob1p complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034974 name: Swi5-Swi2 complex namespace: cellular_component def: "A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching." [PMID:14663140] comment: Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p. synonym: "Swi5 complex" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0034975 name: protein folding in endoplasmic reticulum namespace: biological_process def: "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] synonym: "protein folding in ER" EXACT [] is_a: GO:0006457 ! protein folding [Term] id: GO:0034976 name: response to endoplasmic reticulum stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah] synonym: "ER stress response" EXACT [] synonym: "response to ER stress" EXACT [] is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0034977 name: ABIN2-NFKB1-MAP3K8 complex namespace: cellular_component def: "A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages." [PMID:15169888] synonym: "ABIN2-NFKB1-TPL-1 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0034978 name: PDX1-PBX1b-MRG1 complex namespace: cellular_component def: "A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes." [PMID:11279116, PMID:9710595] synonym: "acinar cell-specific C complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0034979 name: NAD-dependent protein deacetylase activity namespace: molecular_function def: "Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD." [GOC:BHF, GOC:mah] is_a: GO:0033558 ! protein deacetylase activity [Term] id: GO:0034980 name: FHL2-CREB complex namespace: cellular_component def: "A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation." [PMID:11046156] is_a: GO:0033202 ! DNA helicase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0034981 name: FHL3-CREB complex namespace: cellular_component def: "A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation." [PMID:11046156] is_a: GO:0033202 ! DNA helicase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0034982 name: mitochondrial protein processing namespace: biological_process def: "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators] synonym: "mitochondrial protein modification" RELATED [] is_a: GO:0016485 ! protein processing is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0034983 name: peptidyl-lysine deacetylation namespace: biological_process def: "The removal of an acetyl group from an acetylated lysine residue in a peptide or protein." [GOC:BHF, GOC:mah] synonym: "protein lysine acetylation" RELATED [] is_a: GO:0006476 ! protein deacetylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0034985 name: Ecsit-NDUFAF1 complex namespace: cellular_component def: "Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed." [PMID:17344420] is_a: GO:0043234 ! protein complex is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0034986 name: iron chaperone activity namespace: molecular_function def: "Assists in the delivery of iron ions to target proteins or compartments." [GOC:vk] is_a: GO:0005506 ! iron ion binding is_a: GO:0016530 ! metallochaperone activity [Term] id: GO:0034987 name: immunoglobulin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule." [GOC:BHF, GOC:vk] synonym: "Fc receptor binding" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0034988 name: Fc-gamma receptor I complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG." [GOC:BHF, GOC:vk] is_a: GO:0034987 ! immunoglobulin receptor binding [Term] id: GO:0034989 name: GTP-Ral binding namespace: molecular_function def: "Interacting selectively and non-covalently with the GTP-bound form of the Ral protein." [GOC:vk] is_a: GO:0017160 ! Ral GTPase binding [Term] id: GO:0034990 name: nuclear mitotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah] comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. is_a: GO:0000798 ! nuclear cohesin complex is_a: GO:0030892 ! mitotic cohesin complex [Term] id: GO:0034991 name: nuclear meiotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah] comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. is_a: GO:0000798 ! nuclear cohesin complex is_a: GO:0030893 ! meiotic cohesin complex [Term] id: GO:0034992 name: microtubule organizing center attachment site namespace: cellular_component def: "A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope." [GOC:mah, PMID:18692466] comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. synonym: "MAS" EXACT [] synonym: "microtubule organising centre attachment site" EXACT [] synonym: "MTOC attachment site" EXACT [] is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0034993 name: SUN-KASH complex namespace: cellular_component def: "A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains." [GOC:mah, PMID:18692466] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0034992 ! microtubule organizing center attachment site [Term] id: GO:0034994 name: microtubule organizing center attachment site organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches." [GOC:mah, PMID:18692466] synonym: "MAS organization" EXACT [] synonym: "microtubule organising centre attachment site organisation" RELATED [] synonym: "MTOC attachment site organization" EXACT [] is_a: GO:0071842 ! cellular component organization at cellular level relationship: part_of GO:0006998 ! nuclear envelope organization [Term] id: GO:0034995 name: SC5b-7 complex namespace: cellular_component def: "A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly." [PMID:10090939] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0034996 name: RasGAP-Fyn-Lyn-Yes complex namespace: cellular_component def: "A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation." [PMID:1544885] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0034997 name: alphav-beta5 integrin-vitronectin complex namespace: cellular_component def: "A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin." [PMID:1694173, Reactome:REACT_14045.1] synonym: "ITGAV-ITGB5-VTN complex" NARROW [CORUM:3117] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0034998 name: oligosaccharyltransferase I complex namespace: cellular_component def: "An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes." [PMID:15835887] synonym: "OSTCI" EXACT [] is_a: GO:0008250 ! oligosaccharyltransferase complex [Term] id: GO:0034999 name: oligosaccharyltransferase II complex namespace: cellular_component def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes." [GOC:BHF, PMID:15835887] synonym: "OSTCII" EXACT [] is_a: GO:0008250 ! oligosaccharyltransferase complex [Term] id: GO:0035000 name: oligosaccharyltransferase III complex namespace: cellular_component def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes." [PMID:15835887] synonym: "OSTCIII" EXACT [] is_a: GO:0008250 ! oligosaccharyltransferase complex [Term] id: GO:0035001 name: dorsal trunk growth, open tracheal system namespace: biological_process def: "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238] synonym: "dorsal trunk growth" RELATED [] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035002 name: liquid clearance, open tracheal system namespace: biological_process def: "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352] synonym: "tracheal liquid clearance" EXACT [] is_a: GO:0042045 ! epithelial fluid transport relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035003 name: subapical complex namespace: cellular_component def: "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938] synonym: "SAC" BROAD [] is_a: GO:0032991 ! macromolecular complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0035004 name: phosphatidylinositol 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3]." [GOC:bf, PMID:10209156, PMID:9255069] synonym: "phosphoinositide 3-kinase activity" EXACT [GOC:curators] xref: EC:2.7.1.- xref: Wikipedia:Phosphoinositide_3-kinase is_a: GO:0001727 ! lipid kinase activity is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0035005 name: phosphatidylinositol-4-phosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.154] synonym: "C2-domain-containing phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.154] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "type II phosphoinositide 3-kinase activity" RELATED [EC:2.7.1.154] xref: EC:2.7.1.154 xref: KEGG:R05795 xref: MetaCyc:2.7.1.154-RXN xref: RHEA:18376 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity [Term] id: GO:0035006 name: melanization defense response namespace: biological_process def: "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] synonym: "melanization defence response" EXACT [] is_a: GO:0006582 ! melanin metabolic process is_a: GO:0045087 ! innate immune response [Term] id: GO:0035007 name: regulation of melanization defense response namespace: biological_process def: "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf] synonym: "regulation of melanization defence response" EXACT [] is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0035006 ! melanization defense response [Term] id: GO:0035008 name: positive regulation of melanization defense response namespace: biological_process def: "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf] synonym: "activation of melanization defense response" NARROW [] synonym: "positive regulation of melanization defence response" EXACT [] synonym: "stimulation of melanization defense response" NARROW [] synonym: "up regulation of melanization defense response" EXACT [] synonym: "up-regulation of melanization defense response" EXACT [] synonym: "upregulation of melanization defense response" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0035007 ! regulation of melanization defense response is_a: GO:0045089 ! positive regulation of innate immune response relationship: positively_regulates GO:0035006 ! melanization defense response [Term] id: GO:0035009 name: negative regulation of melanization defense response namespace: biological_process def: "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809] synonym: "down regulation of melanization defense response" EXACT [] synonym: "down-regulation of melanization defense response" EXACT [] synonym: "downregulation of melanization defense response" EXACT [] synonym: "inhibition of melanization defense response" NARROW [] synonym: "negative regulation of melanization defence response" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0035007 ! regulation of melanization defense response is_a: GO:0045824 ! negative regulation of innate immune response relationship: negatively_regulates GO:0035006 ! melanization defense response [Term] id: GO:0035010 name: encapsulation of foreign target namespace: biological_process def: "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920] comment: This term was improved by GO_REF:0000022. It was moved. is_a: GO:0002252 ! immune effector process [Term] id: GO:0035011 name: melanotic encapsulation of foreign target namespace: biological_process def: "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] is_a: GO:0035006 ! melanization defense response is_a: GO:0035010 ! encapsulation of foreign target [Term] id: GO:0035012 name: polytene chromosome, telomeric region namespace: cellular_component def: "The terminal region of a polytene chromosome." [GOC:bf] is_a: GO:0000781 ! chromosome, telomeric region relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0035013 name: myosuppressin receptor activity namespace: molecular_function def: "Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0035014 name: phosphatidylinositol 3-kinase regulator activity namespace: molecular_function def: "Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069] comment: See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'. synonym: "phosphoinositide 3-kinase regulator activity" EXACT [GOC:curators] synonym: "PI3K regulator activity" EXACT [] is_a: GO:0019207 ! kinase regulator activity [Term] id: GO:0035015 name: elongation of arista core namespace: biological_process def: "The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0048800 ! antennal morphogenesis [Term] id: GO:0035016 name: elongation of arista lateral namespace: biological_process def: "The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0048800 ! antennal morphogenesis [Term] id: GO:0035017 name: cuticle pattern formation namespace: biological_process def: "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] is_a: GO:0003002 ! regionalization relationship: part_of GO:0042335 ! cuticle development [Term] id: GO:0035018 name: adult chitin-based cuticle pattern formation namespace: biological_process def: "The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "adult cuticle pattern formation" BROAD [] is_a: GO:0035017 ! cuticle pattern formation relationship: part_of GO:0008365 ! adult chitin-based cuticle development [Term] id: GO:0035019 name: somatic stem cell maintenance namespace: biological_process def: "The process in which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] is_a: GO:0019827 ! stem cell maintenance [Term] id: GO:0035020 name: regulation of Rac protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0016601 ! Rac protein signal transduction [Term] id: GO:0035021 name: negative regulation of Rac protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] synonym: "down regulation of Rac protein signal transduction" EXACT [] synonym: "down-regulation of Rac protein signal transduction" EXACT [] synonym: "downregulation of Rac protein signal transduction" EXACT [] synonym: "inhibition of Rac protein signal transduction" NARROW [] is_a: GO:0035020 ! regulation of Rac protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction relationship: negatively_regulates GO:0016601 ! Rac protein signal transduction [Term] id: GO:0035022 name: positive regulation of Rac protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] synonym: "activation of Rac protein signal transduction" NARROW [] synonym: "stimulation of Rac protein signal transduction" NARROW [] synonym: "up regulation of Rac protein signal transduction" EXACT [] synonym: "up-regulation of Rac protein signal transduction" EXACT [] synonym: "upregulation of Rac protein signal transduction" EXACT [] is_a: GO:0035020 ! regulation of Rac protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction relationship: positively_regulates GO:0016601 ! Rac protein signal transduction [Term] id: GO:0035023 name: regulation of Rho protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0007266 ! Rho protein signal transduction [Term] id: GO:0035024 name: negative regulation of Rho protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] synonym: "down regulation of Rho protein signal transduction" EXACT [] synonym: "down-regulation of Rho protein signal transduction" EXACT [] synonym: "downregulation of Rho protein signal transduction" EXACT [] synonym: "inhibition of Rho protein signal transduction" NARROW [] is_a: GO:0035023 ! regulation of Rho protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction relationship: negatively_regulates GO:0007266 ! Rho protein signal transduction [Term] id: GO:0035025 name: positive regulation of Rho protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] synonym: "activation of Rho protein signal transduction" NARROW [] synonym: "stimulation of Rho protein signal transduction" NARROW [] synonym: "up regulation of Rho protein signal transduction" EXACT [] synonym: "up-regulation of Rho protein signal transduction" EXACT [] synonym: "upregulation of Rho protein signal transduction" EXACT [] is_a: GO:0035023 ! regulation of Rho protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction relationship: positively_regulates GO:0007266 ! Rho protein signal transduction [Term] id: GO:0035026 name: leading edge cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet." [GOC:bf] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0035027 name: leading edge cell fate commitment namespace: biological_process def: "The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet." [GOC:bf] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0035026 ! leading edge cell differentiation [Term] id: GO:0035028 name: leading edge cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0035027 ! leading edge cell fate commitment [Term] id: GO:0035029 name: dorsal closure, leading edge cell fate commitment namespace: biological_process def: "The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis." [GOC:bf] is_a: GO:0035027 ! leading edge cell fate commitment relationship: part_of GO:0046663 ! dorsal closure, leading edge cell differentiation [Term] id: GO:0035032 name: phosphatidylinositol 3-kinase complex, class III namespace: cellular_component def: "A complex containing a heterodimer of a catalytic Class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069] synonym: "class III PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class III" EXACT [GOC:curators] is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex [Term] id: GO:0035033 name: histone deacetylase regulator activity namespace: molecular_function def: "Modulates the activity of histone deacetylase." [GOC:bf] comment: See also the molecular function term 'histone deacetylase activity ; GO:0004407'. is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0035034 name: histone acetyltransferase regulator activity namespace: molecular_function def: "Modulates the activity of histone acetyltransferase." [GOC:bf] comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "histone acetylase regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0035035 name: histone acetyltransferase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme histone acetyltransferase." [GOC:bf] synonym: "histone acetylase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0035036 name: sperm-egg recognition namespace: biological_process def: "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] is_a: GO:0009988 ! cell-cell recognition is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035037 name: sperm entry namespace: biological_process def: "An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur." [GOC:bf, PMID:9630751] is_a: GO:0006897 ! endocytosis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035038 name: female pronucleus assembly namespace: biological_process def: "Assembly of the haploid nucleus of the unfertilized egg." [GOC:bf, ISBN:0582227089] synonym: "female pronucleus assembly" RELATED [GOC:dph] is_a: GO:0006997 ! nucleus organization is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035039 name: male pronucleus assembly namespace: biological_process def: "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division." [GOC:bf, PMID:11735001] synonym: "male pronucleus formation" RELATED [GOC:dph] is_a: GO:0006997 ! nucleus organization is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035040 name: sperm nuclear envelope removal namespace: biological_process def: "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus." [GOC:bf, PMID:11735001] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051081 ! nuclear envelope disassembly relationship: part_of GO:0035039 ! male pronucleus assembly [Term] id: GO:0035041 name: sperm chromatin decondensation namespace: biological_process def: "Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001] is_a: GO:0006325 ! chromatin organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0035039 ! male pronucleus assembly [Term] id: GO:0035042 name: fertilization, exchange of chromosomal proteins namespace: biological_process def: "Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001] synonym: "sperm-specific histone exchange" EXACT [] synonym: "sperm-specific histone replacement" EXACT [] is_a: GO:0043486 ! histone exchange is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0035041 ! sperm chromatin decondensation [Term] id: GO:0035043 name: male pronuclear envelope synthesis namespace: biological_process def: "Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation." [GOC:bf, PMID:11735001] is_a: GO:0018985 ! pronuclear envelope synthesis relationship: part_of GO:0035039 ! male pronucleus assembly [Term] id: GO:0035044 name: sperm aster formation namespace: biological_process def: "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035045 name: sperm plasma membrane disassembly namespace: biological_process def: "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238] synonym: "sperm plasma membrane breakdown" EXACT [] synonym: "sperm plasma membrane catabolism" EXACT [] synonym: "sperm plasma membrane degradation" EXACT [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030397 ! membrane disassembly relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035046 name: pronuclear migration namespace: biological_process def: "The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035047 name: centrosomal and pronuclear rotation namespace: biological_process def: "The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion." [GOC:bf, ISBN:087969307X, PMID:10085292] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035048 name: splicing factor protein import into nucleus namespace: biological_process def: "The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:bf] synonym: "splicing factor protein transport from cytoplasm to nucleus" EXACT [] synonym: "splicing factor protein-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0035049 name: juvenile hormone acid methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0035050 name: embryonic heart tube development namespace: biological_process def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] is_a: GO:0035295 ! tube development relationship: part_of GO:0007507 ! heart development relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0035051 name: cardiac cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf] synonym: "heart cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007507 ! heart development [Term] id: GO:0035052 name: dorsal vessel aortic cell fate commitment namespace: biological_process def: "The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern formation [Term] id: GO:0035053 name: dorsal vessel heart proper cell fate commitment namespace: biological_process def: "The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern formation [Term] id: GO:0035054 name: embryonic heart tube anterior/posterior pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta." [GOC:bf, PMID:12435360] is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0035050 ! embryonic heart tube development [Term] id: GO:0035058 name: nonmotile primary cilium assembly namespace: biological_process def: "The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834] synonym: "immotile primary cilium assembly" EXACT [GOC:bf] synonym: "nonmotile primary cilia assembly" RELATED [GOC:bf] synonym: "sensory cilium assembly" EXACT [GOC:kmv] synonym: "sensory cilium biogenesis" RELATED [GOC:mah] is_a: GO:0042384 ! cilium assembly [Term] id: GO:0035059 name: RCAF complex namespace: cellular_component def: "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4." [GOC:bf, PMID:10591219] synonym: "replication-coupling assembly factor complex" EXACT [] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0035060 name: brahma complex namespace: cellular_component def: "A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982] synonym: "BRM complex" EXACT [] is_a: GO:0070603 ! SWI/SNF-type complex [Term] id: GO:0035061 name: interchromatin granule namespace: cellular_component def: "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] synonym: "ICG" EXACT [] xref: NIF_Subcellular:sao1049471211 is_a: GO:0016604 ! nuclear body [Term] id: GO:0035062 name: omega speckle namespace: cellular_component def: "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] is_a: GO:0016607 ! nuclear speck [Term] id: GO:0035063 name: nuclear speck organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized." [GOC:bf, GOC:curators] comment: See also the cellular component term 'nuclear speck ; GO:0016607'. synonym: "nuclear speck organisation" EXACT [GOC:curators] synonym: "nuclear speck organization and biogenesis" RELATED [GOC:mah] synonym: "nuclear speckle assembly" NARROW [GOC:mah] synonym: "nuclear speckle organization" EXACT [] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0035064 name: methylated histone residue binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated residue on a histone protein. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615] is_a: GO:0042393 ! histone binding [Term] id: GO:0035065 name: regulation of histone acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] is_a: GO:0031056 ! regulation of histone modification relationship: regulates GO:0016573 ! histone acetylation [Term] id: GO:0035066 name: positive regulation of histone acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] synonym: "activation of histone acetylation" NARROW [] synonym: "stimulation of histone acetylation" NARROW [] synonym: "up regulation of histone acetylation" EXACT [] synonym: "up-regulation of histone acetylation" EXACT [] synonym: "upregulation of histone acetylation" EXACT [] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0035065 ! regulation of histone acetylation relationship: positively_regulates GO:0016573 ! histone acetylation [Term] id: GO:0035067 name: negative regulation of histone acetylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] synonym: "down regulation of histone acetylation" EXACT [] synonym: "down-regulation of histone acetylation" EXACT [] synonym: "downregulation of histone acetylation" EXACT [] synonym: "inhibition of histone acetylation" NARROW [] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0035065 ! regulation of histone acetylation relationship: negatively_regulates GO:0016573 ! histone acetylation [Term] id: GO:0035068 name: micro-ribonucleoprotein complex namespace: cellular_component def: "A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA." [GOC:bf, PMID:14559182] synonym: "miRNP complex" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0035069 name: larval midgut histolysis namespace: biological_process def: "The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] is_a: GO:0007559 ! histolysis relationship: part_of GO:0007552 ! metamorphosis relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis [Term] id: GO:0035070 name: salivary gland histolysis namespace: biological_process def: "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] is_a: GO:0007435 ! salivary gland morphogenesis is_a: GO:0007559 ! histolysis is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007552 ! metamorphosis relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis [Term] id: GO:0035071 name: salivary gland cell autophagic cell death namespace: biological_process def: "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, PMID:10882130] synonym: "autophagic cell death of salivary gland cells" EXACT [] synonym: "programmed cell death of salivary gland cells by autophagy" EXACT [] synonym: "salivary gland cell death" EXACT [] synonym: "salivary gland cell programmed cell death by autophagy" EXACT [] is_a: GO:0048102 ! autophagic cell death relationship: part_of GO:0035070 ! salivary gland histolysis [Term] id: GO:0035072 name: ecdysone-mediated induction of salivary gland cell autophagic cell death namespace: biological_process def: "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf] synonym: "ecdysone-mediated induction of autophagic cell death of salivary gland cells" EXACT [] synonym: "ecdysone-mediated induction of programmed cell death of salivary gland cells by autophagy" EXACT [] synonym: "ecdysone-mediated induction of salivary gland cell programmed cell death by autophagy" EXACT [] is_a: GO:0035078 ! induction of programmed cell death by ecdysone relationship: part_of GO:0035071 ! salivary gland cell autophagic cell death [Term] id: GO:0035073 name: pupariation namespace: biological_process def: "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] synonym: "puparium biosynthesis" EXACT [] synonym: "puparium formation" EXACT [] is_a: GO:0032502 ! developmental process relationship: part_of GO:0035210 ! prepupal development [Term] id: GO:0035074 name: pupation namespace: biological_process def: "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238] synonym: "head eversion" EXACT [] synonym: "prepupal-pupal transition" EXACT [] xref: Wikipedia:Pupa is_a: GO:0032502 ! developmental process relationship: part_of GO:0035209 ! pupal development [Term] id: GO:0035075 name: response to ecdysone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] is_a: GO:0048545 ! response to steroid hormone stimulus relationship: part_of GO:0002165 ! instar larval or pupal development [Term] id: GO:0035076 name: ecdysone receptor-mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf] synonym: "ecdysone receptor-mediated signalling pathway" EXACT [] is_a: GO:0030518 ! steroid hormone receptor signaling pathway is_a: GO:0071390 ! cellular response to ecdysone [Term] id: GO:0035077 name: ecdysone-mediated polytene chromosome puffing namespace: biological_process def: "The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation." [GOC:bf, PMID:12543962] is_a: GO:0035079 ! polytene chromosome puffing is_a: GO:0071390 ! cellular response to ecdysone [Term] id: GO:0035078 name: induction of programmed cell death by ecdysone namespace: biological_process def: "Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf] is_a: GO:0035075 ! response to ecdysone is_a: GO:0035081 ! induction of programmed cell death by hormones [Term] id: GO:0035079 name: polytene chromosome puffing namespace: biological_process def: "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals." [GOC:bf, PMID:12543962] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0035080 name: heat shock-mediated polytene chromosome puffing namespace: biological_process def: "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962] is_a: GO:0034605 ! cellular response to heat is_a: GO:0035079 ! polytene chromosome puffing [Term] id: GO:0035081 name: induction of programmed cell death by hormones namespace: biological_process def: "Any process induced by hormones that directly activates any of the steps required for programmed cell death." [GOC:bf] is_a: GO:0012502 ! induction of programmed cell death [Term] id: GO:0035082 name: axoneme assembly namespace: biological_process def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0815316194] synonym: "axoneme biogenesis" RELATED [GOC:mah] is_a: GO:0001578 ! microtubule bundle formation is_a: GO:0030031 ! cell projection assembly [Term] id: GO:0035083 name: cilium axoneme assembly namespace: biological_process def: "The assembly of a the bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0815316194] synonym: "cilium axoneme biogenesis" RELATED [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0035082 ! axoneme assembly relationship: part_of GO:0042384 ! cilium assembly [Term] id: GO:0035084 name: flagellar axoneme assembly namespace: biological_process def: "The assembly of the bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0815316194] synonym: "flagella axoneme assembly" EXACT [GOC:mah] synonym: "flagella axoneme biogenesis" RELATED [] synonym: "flagellar axoneme biogenesis" RELATED [] synonym: "flagellum axoneme assembly" EXACT [GOC:mah] synonym: "flagellum axoneme biogenesis" RELATED [] is_a: GO:0035082 ! axoneme assembly relationship: part_of GO:0009296 ! flagellum assembly [Term] id: GO:0035085 name: cilium axoneme namespace: cellular_component def: "The bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684] is_a: GO:0005930 ! axoneme is_a: GO:0044441 ! cilium part [Term] id: GO:0035086 name: flagellar axoneme namespace: cellular_component def: "The bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684] synonym: "flagellum axoneme" EXACT [] is_a: GO:0005930 ! axoneme is_a: GO:0044442 ! microtubule-based flagellum part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0097014 ! microtubule-based flagellar cytoplasm [Term] id: GO:0035087 name: siRNA loading onto RISC involved in RNA interference namespace: biological_process def: "The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631] synonym: "RNA interference, siRNA loading onto RISC" EXACT [GOC:mah] is_a: GO:0070922 ! small RNA loading onto RISC relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0035088 name: establishment or maintenance of apical/basal cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity [Term] id: GO:0035089 name: establishment of apical/basal cell polarity namespace: biological_process def: "The specification and formation of the polarity of a cell along its apical/basal axis." [GOC:bf] is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity is_a: GO:0061162 ! establishment of monopolar cell polarity [Term] id: GO:0035090 name: maintenance of apical/basal cell polarity namespace: biological_process def: "Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf] is_a: GO:0030011 ! maintenance of cell polarity is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity [Term] id: GO:0035091 name: phosphatidylinositol binding namespace: molecular_function def: "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11395417] synonym: "phosphoinositide binding" EXACT [GOC:curators] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0035092 name: sperm chromatin condensation namespace: biological_process def: "The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication." [GOC:bf, PMID:11735001] is_a: GO:0006323 ! DNA packaging is_a: GO:0006325 ! chromatin organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0035093 name: spermatogenesis, exchange of chromosomal proteins namespace: biological_process def: "The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin." [GOC:bf, PMID:11735001] synonym: "somatic histone exchange" EXACT [] synonym: "somatic histone replacement" RELATED [] is_a: GO:0043486 ! histone exchange is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0035092 ! sperm chromatin condensation [Term] id: GO:0035094 name: response to nicotine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0582227089] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0035095 name: behavioral response to nicotine namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "behavioural response to nicotine" EXACT [] is_a: GO:0030534 ! adult behavior is_a: GO:0035094 ! response to nicotine [Term] id: GO:0035096 name: larval midgut cell programmed cell death namespace: biological_process def: "The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ." [GOC:bf] synonym: "larval midgut cell death" EXACT [] synonym: "programmed cell death of larval midgut cells" EXACT [] is_a: GO:0010623 ! developmental programmed cell death relationship: part_of GO:0035069 ! larval midgut histolysis [Term] id: GO:0035097 name: histone methyltransferase complex namespace: cellular_component def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf] subset: goslim_pir is_a: GO:0034708 ! methyltransferase complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0035098 name: ESC/E(Z) complex namespace: cellular_component def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375] synonym: "Extra Sex Combs/Enhancer of Zeste complex" EXACT [] synonym: "PRC2 complex" EXACT [GOC:sp, PMID:20064375] is_a: GO:0031519 ! PcG protein complex is_a: GO:0035097 ! histone methyltransferase complex [Term] id: GO:0035099 name: hemocyte migration namespace: biological_process def: "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] synonym: "arthropod blood cell migration" EXACT [] synonym: "hemocyte cell migration" EXACT [] is_a: GO:0016477 ! cell migration relationship: part_of GO:0035162 ! embryonic hemopoiesis [Term] id: GO:0035100 name: ecdysone binding namespace: molecular_function def: "Interacting selectively and non-covalently with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0582227089] is_a: GO:0005496 ! steroid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0035101 name: FACT complex namespace: cellular_component def: "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108] synonym: "Facilitates chromatin transcription complex" EXACT [] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0035102 name: PRC1 complex namespace: cellular_component def: "An insect multiprotein complex containing the products of many of the Polycomb Group genes including Polycomb, Posterior sex combs, polyhomeotic and Sex comb on midleg. The Polycomb Group proteins are required for stable long-term maintenance of transcriptionally repressed states and the PRC1 complex directly antagonizes ATP-dependent remodeling of nucleosomal arrays." [GOC:bf, PMID:10412979] synonym: "Polycomb repressive complex 1" EXACT [] is_a: GO:0031519 ! PcG protein complex [Term] id: GO:0035103 name: sterol regulatory element binding protein cleavage namespace: biological_process def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, PMID:12923525] synonym: "SREBP cleavage" EXACT [] is_a: GO:0044267 ! cellular protein metabolic process is_a: GO:0051605 ! protein maturation by peptide bond cleavage relationship: part_of GO:0032933 ! SREBP-mediated signaling pathway [Term] id: GO:0035104 name: positive regulation of transcription via sterol regulatory element binding namespace: biological_process def: "The process in which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs in the promoters of target genes." [GOC:bf, GOC:mah, PMID:12923525] synonym: "activation of sterol regulatory element binding protein target gene transcription" NARROW [] synonym: "positive regulation of sterol regulatory element binding protein target gene transcription" EXACT [GOC:dph, GOC:tb] synonym: "SREBP target gene transcriptional activation" EXACT [] synonym: "sterol regulatory element binding protein target gene transcriptional activation" BROAD [] synonym: "stimulation of sterol regulatory element binding protein target gene transcription" NARROW [] synonym: "up regulation of sterol regulatory element binding protein target gene transcription" EXACT [] synonym: "up-regulation of sterol regulatory element binding protein target gene transcription" EXACT [] synonym: "upregulation of sterol regulatory element binding protein target gene transcription" EXACT [] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0032933 ! SREBP-mediated signaling pathway [Term] id: GO:0035105 name: sterol regulatory element binding protein import into nucleus namespace: biological_process def: "The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "SREBP import into nucleus" EXACT [GOC:mah] synonym: "SREBP nuclear translocation" NARROW [GOC:mah] synonym: "sterol regulatory element binding protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0006606 ! protein import into nucleus relationship: part_of GO:0032933 ! SREBP-mediated signaling pathway [Term] id: GO:0035106 name: operant conditioning namespace: biological_process def: "Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373] synonym: "instrumental conditioning" EXACT [] xref: Wikipedia:Operant_conditioning is_a: GO:0007612 ! learning [Term] id: GO:0035107 name: appendage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048736 ! appendage development [Term] id: GO:0035108 name: limb morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [ISBN:0395825172] synonym: "limb bud morphogenesis" NARROW [GOC:dph] is_a: GO:0035107 ! appendage morphogenesis relationship: part_of GO:0060173 ! limb development [Term] id: GO:0035109 name: imaginal disc-derived limb morphogenesis namespace: biological_process def: "The process in which the anatomical structures of limbs that are derived from an imaginal disc are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0035108 ! limb morphogenesis is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis [Term] id: GO:0035110 name: leg morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf, ISBN:0198612001] is_a: GO:0035108 ! limb morphogenesis [Term] id: GO:0035111 name: leg joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. One example is the knee, which separates the leg tibia and femur." [GOC:bf, ISBN:0582227089, PMID:12051824] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0035286 ! leg segmentation [Term] id: GO:0035112 name: genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf] synonym: "genital morphogenesis" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0048806 ! genitalia development [Term] id: GO:0035113 name: embryonic appendage morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] is_a: GO:0035107 ! appendage morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0035114 name: imaginal disc-derived appendage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:mtg_sensu, ISBN:0582227089] is_a: GO:0035107 ! appendage morphogenesis relationship: part_of GO:0048737 ! imaginal disc-derived appendage development [Term] id: GO:0035115 name: embryonic forelimb morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal." [ISBN:0198612001] is_a: GO:0030326 ! embryonic limb morphogenesis is_a: GO:0035136 ! forelimb morphogenesis [Term] id: GO:0035116 name: embryonic hindlimb morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal." [ISBN:0198612001] is_a: GO:0030326 ! embryonic limb morphogenesis is_a: GO:0035137 ! hindlimb morphogenesis [Term] id: GO:0035117 name: embryonic arm morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the arm are generated and organized. In humans, the arms are the two upper limbs of the body from the shoulder to the hand." [ISBN:0198612001] is_a: GO:0035115 ! embryonic forelimb morphogenesis is_a: GO:0035140 ! arm morphogenesis [Term] id: GO:0035118 name: embryonic pectoral fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0035115 ! embryonic forelimb morphogenesis is_a: GO:0035138 ! pectoral fin morphogenesis [Term] id: GO:0035119 name: embryonic pelvic fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0035116 ! embryonic hindlimb morphogenesis is_a: GO:0035139 ! pelvic fin morphogenesis [Term] id: GO:0035120 name: post-embryonic appendage morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0035107 ! appendage morphogenesis [Term] id: GO:0035121 name: tail morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tail are generated and organized. The tail is the hindmost part of some animals." [ISBN:0198612001] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0035122 name: embryonic medial fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] synonym: "embryonic unpaired fin morphogenesis" EXACT [] is_a: GO:0035113 ! embryonic appendage morphogenesis is_a: GO:0035141 ! medial fin morphogenesis [Term] id: GO:0035123 name: embryonic dorsal fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] is_a: GO:0035122 ! embryonic medial fin morphogenesis is_a: GO:0035142 ! dorsal fin morphogenesis [Term] id: GO:0035124 name: embryonic caudal fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh] is_a: GO:0035122 ! embryonic medial fin morphogenesis is_a: GO:0035143 ! caudal fin morphogenesis [Term] id: GO:0035125 name: embryonic anal fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] is_a: GO:0035122 ! embryonic medial fin morphogenesis is_a: GO:0035144 ! anal fin morphogenesis [Term] id: GO:0035126 name: post-embryonic genitalia morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf] synonym: "post-embryonic genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis is_a: GO:0048563 ! post-embryonic organ morphogenesis [Term] id: GO:0035127 name: post-embryonic limb morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [ISBN:0395825172] is_a: GO:0035108 ! limb morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis [Term] id: GO:0035128 name: post-embryonic forelimb morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism." [GOC:bf] is_a: GO:0035127 ! post-embryonic limb morphogenesis is_a: GO:0035136 ! forelimb morphogenesis [Term] id: GO:0035129 name: post-embryonic hindlimb morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized." [GOC:bf] is_a: GO:0035127 ! post-embryonic limb morphogenesis is_a: GO:0035137 ! hindlimb morphogenesis [Term] id: GO:0035130 name: post-embryonic pectoral fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0035128 ! post-embryonic forelimb morphogenesis is_a: GO:0035138 ! pectoral fin morphogenesis [Term] id: GO:0035131 name: post-embryonic pelvic fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0035129 ! post-embryonic hindlimb morphogenesis is_a: GO:0035139 ! pelvic fin morphogenesis [Term] id: GO:0035132 name: post-embryonic medial fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] synonym: "post-embryonic unpaired fin morphogenesis" EXACT [] is_a: GO:0035120 ! post-embryonic appendage morphogenesis is_a: GO:0035141 ! medial fin morphogenesis [Term] id: GO:0035133 name: post-embryonic caudal fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh] is_a: GO:0035132 ! post-embryonic medial fin morphogenesis is_a: GO:0035143 ! caudal fin morphogenesis [Term] id: GO:0035134 name: post-embryonic dorsal fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] is_a: GO:0035132 ! post-embryonic medial fin morphogenesis is_a: GO:0035142 ! dorsal fin morphogenesis [Term] id: GO:0035135 name: post-embryonic anal fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] is_a: GO:0035132 ! post-embryonic medial fin morphogenesis is_a: GO:0035144 ! anal fin morphogenesis [Term] id: GO:0035136 name: forelimb morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the forelimb are generated and organized." [GOC:go_curators] is_a: GO:0035108 ! limb morphogenesis [Term] id: GO:0035137 name: hindlimb morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindlimb are generated and organized." [GOC:go_curators] is_a: GO:0035108 ! limb morphogenesis [Term] id: GO:0035138 name: pectoral fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0033334 ! fin morphogenesis is_a: GO:0035136 ! forelimb morphogenesis relationship: part_of GO:0033339 ! pectoral fin development [Term] id: GO:0035139 name: pelvic fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pelvic fin are generated and organized. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0033334 ! fin morphogenesis is_a: GO:0035137 ! hindlimb morphogenesis relationship: part_of GO:0033340 ! pelvic fin development [Term] id: GO:0035140 name: arm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the arm are generated and organized. In humans, the arms are the two upper limbs of the body from the shoulder to the hand." [ISBN:0198612001] is_a: GO:0035136 ! forelimb morphogenesis [Term] id: GO:0035141 name: medial fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] synonym: "unpaired fin morphogenesis" EXACT [] is_a: GO:0033334 ! fin morphogenesis relationship: part_of GO:0033338 ! medial fin development [Term] id: GO:0035142 name: dorsal fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] is_a: GO:0035141 ! medial fin morphogenesis relationship: part_of GO:0033337 ! dorsal fin development [Term] id: GO:0035143 name: caudal fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion." [GOC:dgh] is_a: GO:0035141 ! medial fin morphogenesis relationship: part_of GO:0033336 ! caudal fin development [Term] id: GO:0035144 name: anal fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] is_a: GO:0035141 ! medial fin morphogenesis relationship: part_of GO:0033335 ! anal fin development [Term] id: GO:0035145 name: exon-exon junction complex namespace: cellular_component def: "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] synonym: "EJC" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0035146 name: tube fusion namespace: biological_process def: "The joining of specific branches of a tubular system to form a continuous network." [GOC:bf] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0048754 ! branching morphogenesis of a tube [Term] id: GO:0035147 name: branch fusion, open tracheal system namespace: biological_process def: "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] synonym: "tracheal branch fusion" EXACT [] is_a: GO:0035146 ! tube fusion relationship: part_of GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0035148 name: tube formation namespace: biological_process def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah] synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035239 ! tube morphogenesis [Term] id: GO:0035149 name: lumen formation, open tracheal system namespace: biological_process def: "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] synonym: "tracheal lumen formation" EXACT [] is_a: GO:0035148 ! tube formation is_a: GO:0035152 ! regulation of tube architecture, open tracheal system [Term] id: GO:0035150 name: regulation of tube size namespace: biological_process def: "Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes." [PMID:10887083] is_a: GO:0090066 ! regulation of anatomical structure size [Term] id: GO:0035151 name: regulation of tube size, open tracheal system namespace: biological_process def: "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360] synonym: "regulation of tracheal tube size" EXACT [] is_a: GO:0035150 ! regulation of tube size is_a: GO:0035152 ! regulation of tube architecture, open tracheal system [Term] id: GO:0035152 name: regulation of tube architecture, open tracheal system namespace: biological_process def: "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584] synonym: "regulation of tracheal tube architecture" EXACT [] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035153 name: epithelial cell type specification, open tracheal system namespace: biological_process def: "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] synonym: "tracheal cell type specification" BROAD [] synonym: "tracheal epithelial cell type specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035154 name: terminal cell fate specification, open tracheal system namespace: biological_process def: "The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] synonym: "terminal cell fate specification" EXACT [] is_a: GO:0035153 ! epithelial cell type specification, open tracheal system [Term] id: GO:0035155 name: negative regulation of terminal cell fate specification, open tracheal system namespace: biological_process def: "Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581] synonym: "down regulation of terminal cell fate specification" EXACT [] synonym: "down-regulation of terminal cell fate specification" EXACT [] synonym: "downregulation of terminal cell fate specification" EXACT [] synonym: "inhibition of terminal cell fate specification" NARROW [] synonym: "negative regulation of terminal cell fate specification" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:2000026 ! regulation of multicellular organismal development relationship: negatively_regulates GO:0035154 ! terminal cell fate specification, open tracheal system [Term] id: GO:0035156 name: fusion cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion." [PMID:11063940] is_a: GO:0035153 ! epithelial cell type specification, open tracheal system [Term] id: GO:0035157 name: negative regulation of fusion cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [PMID:10684581] synonym: "down regulation of fusion cell fate specification" EXACT [] synonym: "down-regulation of fusion cell fate specification" EXACT [] synonym: "downregulation of fusion cell fate specification" EXACT [] synonym: "inhibition of fusion cell fate specification" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:2000026 ! regulation of multicellular organismal development relationship: negatively_regulates GO:0035156 ! fusion cell fate specification [Term] id: GO:0035158 name: regulation of tube diameter, open tracheal system namespace: biological_process def: "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584] synonym: "regulation of tracheal tube diameter" EXACT [] synonym: "tracheal tube dilation" NARROW [] synonym: "tracheal tube expansion" NARROW [] is_a: GO:0035296 ! regulation of tube diameter relationship: part_of GO:0035151 ! regulation of tube size, open tracheal system [Term] id: GO:0035159 name: regulation of tube length, open tracheal system namespace: biological_process def: "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] synonym: "regulation of tracheal tube length" EXACT [] synonym: "tracheal tube elongation" NARROW [] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0035151 ! regulation of tube size, open tracheal system [Term] id: GO:0035160 name: maintenance of epithelial integrity, open tracheal system namespace: biological_process def: "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183] synonym: "maintenance of tracheal epithelial integrity" EXACT [] is_a: GO:0010669 ! epithelial structure maintenance is_a: GO:0035152 ! regulation of tube architecture, open tracheal system [Term] id: GO:0035161 name: imaginal disc lineage restriction namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0007447 ! imaginal disc pattern formation [Term] id: GO:0035162 name: embryonic hemopoiesis namespace: biological_process def: "The stages of blood cell formation that take place within the embryo." [GOC:bf] synonym: "embryonic haematopoiesis" EXACT [] synonym: "embryonic haemopoiesis" EXACT [] synonym: "embryonic hematopoiesis" EXACT [] is_a: GO:0030097 ! hemopoiesis is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0035163 name: embryonic hemocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069] synonym: "embryonic arthropod blood cell differentiation" EXACT [] synonym: "embryonic hemocyte cell differentiation" EXACT [] is_a: GO:0042386 ! hemocyte differentiation relationship: part_of GO:0035162 ! embryonic hemopoiesis [Term] id: GO:0035164 name: embryonic plasmatocyte differentiation namespace: biological_process def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791] synonym: "embryonic plasmatocyte cell differentiation" EXACT [] is_a: GO:0035163 ! embryonic hemocyte differentiation is_a: GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0035165 name: embryonic crystal cell differentiation namespace: biological_process def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] is_a: GO:0035163 ! embryonic hemocyte differentiation is_a: GO:0042688 ! crystal cell differentiation [Term] id: GO:0035166 name: post-embryonic hemopoiesis namespace: biological_process def: "The stages of blood cell formation that take place after completion of embryonic development." [GOC:bf] synonym: "post-embryonic haemopoiesis" EXACT [] is_a: GO:0030097 ! hemopoiesis is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0009791 ! post-embryonic development [Term] id: GO:0035167 name: larval lymph gland hemopoiesis namespace: biological_process def: "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385] synonym: "larval lymph gland haematopoiesis" EXACT [] synonym: "larval lymph gland haemopoiesis" EXACT [] synonym: "larval lymph gland hematopoiesis" EXACT [] is_a: GO:0035166 ! post-embryonic hemopoiesis relationship: part_of GO:0002164 ! larval development relationship: part_of GO:0048542 ! lymph gland development [Term] id: GO:0035168 name: larval lymph gland hemocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069] synonym: "larval lymph gland arthropod blood cell differentiation" EXACT [] is_a: GO:0042386 ! hemocyte differentiation relationship: part_of GO:0035167 ! larval lymph gland hemopoiesis [Term] id: GO:0035169 name: lymph gland plasmatocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791] synonym: "lymph gland plasmatocyte cell differentiation" EXACT [] is_a: GO:0035168 ! larval lymph gland hemocyte differentiation is_a: GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0035170 name: lymph gland crystal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] is_a: GO:0035168 ! larval lymph gland hemocyte differentiation is_a: GO:0042688 ! crystal cell differentiation [Term] id: GO:0035171 name: lamellocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104] synonym: "lamellocyte cell differentiation" EXACT [] is_a: GO:0035168 ! larval lymph gland hemocyte differentiation [Term] id: GO:0035172 name: hemocyte proliferation namespace: biological_process def: "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] synonym: "arthropod blood cell proliferation" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0008283 ! cell proliferation [Term] id: GO:0035173 name: histone kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0035174 name: histone serine kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] synonym: "histone-serine kinase activity" EXACT [] is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0035173 ! histone kinase activity [Term] id: GO:0035175 name: histone kinase activity (H3-S10 specific) namespace: molecular_function alt_id: GO:0044021 def: "Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176] synonym: "histone kinase activity (H3-S3 specific)" EXACT [] synonym: "histone serine kinase activity (H3-S10 specific)" EXACT [] synonym: "histone-serine kinase activity (H3-S10 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity [Term] id: GO:0035176 name: social behavior namespace: biological_process def: "Behavior that occurs predominantly, or only, in individuals that are part of a group." [PMID:12848939] synonym: "cooperative behavior" RELATED [] synonym: "social behaviour" EXACT [] xref: Wikipedia:Social_behavior is_a: GO:0051705 ! behavioral interaction between organisms [Term] id: GO:0035177 name: larval foraging behavior namespace: biological_process def: "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927] synonym: "larval foraging behaviour" EXACT [] is_a: GO:0030537 ! larval behavior is_a: GO:0060756 ! foraging behavior [Term] id: GO:0035178 name: turning behavior namespace: biological_process def: "Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source." [PMID:10880478] synonym: "turning behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior [Term] id: GO:0035179 name: larval turning behavior namespace: biological_process def: "Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source." [PMID:10880478] synonym: "larval turning behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior is_a: GO:0035178 ! turning behavior [Term] id: GO:0035180 name: larval wandering behavior namespace: biological_process def: "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960] synonym: "larval wandering behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior [Term] id: GO:0035181 name: larval burrowing behavior namespace: biological_process def: "Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation." [PMID:12848927, PMID:12848939] synonym: "larval burrowing behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior [Term] id: GO:0035182 name: female germline ring canal outer rim namespace: cellular_component def: "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues." [PMID:12435357, PMID:7925006] comment: See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'. synonym: "germline ring canal outer rim" BROAD [] synonym: "nurse cell ring canal outer rim" NARROW [] synonym: "ovarian ring canal outer rim" NARROW [] is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0035324 ! female germline ring canal [Term] id: GO:0035183 name: female germline ring canal inner rim namespace: cellular_component def: "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858] comment: See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'. synonym: "germline ring canal inner rim" BROAD [] synonym: "nurse cell ring canal inner rim" NARROW [] synonym: "ovarian ring canal inner rim" NARROW [] is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0035324 ! female germline ring canal [Term] id: GO:0035184 name: histone threonine kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] synonym: "histone-threonine kinase activity" EXACT [] is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0035173 ! histone kinase activity [Term] id: GO:0035185 name: preblastoderm mitotic cell cycle namespace: biological_process def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238] is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis is_a: GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0035186 name: syncytial blastoderm mitotic cell cycle namespace: biological_process def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis is_a: GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0035187 name: hatching behavior namespace: biological_process def: "The specific actions or reactions of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [PMID:10436051] synonym: "hatching behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0035188 ! hatching [Term] id: GO:0035188 name: hatching namespace: biological_process def: "The emergence of an immature organism from a protective structure." [GOC:dgh, GOC:isa_complete, ISBN:0198612001] is_a: GO:0071684 ! organism emergence from protective structure relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0035189 name: Rb-E2F complex namespace: cellular_component def: "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] synonym: "retinoblastoma-E2F complex" EXACT [] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0035190 name: syncytial nuclear migration namespace: biological_process def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0035191 name: nuclear axial expansion namespace: biological_process def: "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839] synonym: "nuclear distribution along anterior-posterior axis" EXACT [] synonym: "nucleus distribution along anterior-posterior axis" EXACT [] is_a: GO:0035190 ! syncytial nuclear migration [Term] id: GO:0035192 name: nuclear cortical migration namespace: biological_process def: "The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo." [PMID:8314839] is_a: GO:0035190 ! syncytial nuclear migration [Term] id: GO:0035193 name: larval central nervous system remodeling namespace: biological_process def: "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692] synonym: "central nervous system metamorphosis" EXACT [] synonym: "CNS metamorphosis" EXACT [] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0002165 ! instar larval or pupal development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0035194 name: posttranscriptional gene silencing by RNA namespace: biological_process def: "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283] synonym: "RNA-mediated posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] synonym: "sense-PTGS" RELATED [] is_a: GO:0016441 ! posttranscriptional gene silencing is_a: GO:0031047 ! gene silencing by RNA [Term] id: GO:0035195 name: gene silencing by miRNA namespace: biological_process def: "Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [PMID:14744438, PMID:15066275, PMID:15066283] synonym: "microRNA-mediated gene silencing" EXACT [] synonym: "miRNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0035194 ! posttranscriptional gene silencing by RNA [Term] id: GO:0035196 name: production of miRNAs involved in gene silencing by miRNA namespace: biological_process alt_id: GO:0030918 def: "Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283] synonym: "gene silencing by miRNA, production of miRNAs" EXACT [GOC:mah] synonym: "microRNA biogenesis" RELATED [GOC:tb] synonym: "microRNA biosynthesis" RELATED [] synonym: "microRNA biosynthetic process" RELATED [] synonym: "microRNA metabolic process" RELATED [] synonym: "microRNA metabolism" RELATED [] synonym: "microRNA processing" BROAD [] synonym: "microRNA-mediated gene silencing, production of microRNAs" EXACT [] synonym: "miRNA biogenesis" RELATED [GOC:tb] synonym: "miRNA processing" EXACT [] synonym: "miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:dph, GOC:tb] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035197 name: siRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283] synonym: "small interfering RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0035198 name: miRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283] synonym: "microRNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0035199 name: salt aversion namespace: biological_process def: "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf] synonym: "behavioral response to salt" BROAD [] is_a: GO:0007631 ! feeding behavior is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0035200 name: leg disc anterior/posterior pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc." [GOC:bf] is_a: GO:0007448 ! anterior/posterior pattern formation, imaginal disc is_a: GO:0035223 ! leg disc pattern formation [Term] id: GO:0035201 name: leg disc anterior/posterior lineage restriction namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf] is_a: GO:0048099 ! anterior/posterior lineage restriction, imaginal disc relationship: part_of GO:0035200 ! leg disc anterior/posterior pattern formation [Term] id: GO:0035202 name: tracheal pit formation in open tracheal system namespace: biological_process def: "Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584] synonym: "tracheal placode invagination" RELATED [] synonym: "tracheal sac formation" BROAD [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035203 name: regulation of lamellocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] is_a: GO:0045610 ! regulation of hemocyte differentiation is_a: GO:0048580 ! regulation of post-embryonic development relationship: regulates GO:0035171 ! lamellocyte differentiation [Term] id: GO:0035204 name: negative regulation of lamellocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] synonym: "down regulation of lamellocyte differentiation" EXACT [] synonym: "down-regulation of lamellocyte differentiation" EXACT [] synonym: "downregulation of lamellocyte differentiation" EXACT [] synonym: "inhibition of lamellocyte differentiation" NARROW [] is_a: GO:0035203 ! regulation of lamellocyte differentiation is_a: GO:0045611 ! negative regulation of hemocyte differentiation relationship: negatively_regulates GO:0035171 ! lamellocyte differentiation [Term] id: GO:0035205 name: positive regulation of lamellocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] synonym: "activation of lamellocyte differentiation" NARROW [] synonym: "stimulation of lamellocyte differentiation" NARROW [] synonym: "up regulation of lamellocyte differentiation" EXACT [] synonym: "up-regulation of lamellocyte differentiation" EXACT [] synonym: "upregulation of lamellocyte differentiation" EXACT [] is_a: GO:0035203 ! regulation of lamellocyte differentiation is_a: GO:0045612 ! positive regulation of hemocyte differentiation relationship: positively_regulates GO:0035171 ! lamellocyte differentiation [Term] id: GO:0035206 name: regulation of hemocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "regulation of arthropod blood cell proliferation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0035172 ! hemocyte proliferation [Term] id: GO:0035207 name: negative regulation of hemocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "down regulation of hemocyte proliferation" EXACT [] synonym: "down-regulation of hemocyte proliferation" EXACT [] synonym: "downregulation of hemocyte proliferation" EXACT [] synonym: "inhibition of hemocyte proliferation" NARROW [] synonym: "negative regulation of arthropod blood cell proliferation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0035206 ! regulation of hemocyte proliferation relationship: negatively_regulates GO:0035172 ! hemocyte proliferation [Term] id: GO:0035208 name: positive regulation of hemocyte proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "activation of hemocyte proliferation" NARROW [] synonym: "positive regulation of arthropod blood cell proliferation" EXACT [] synonym: "stimulation of hemocyte proliferation" NARROW [] synonym: "up regulation of hemocyte proliferation" EXACT [] synonym: "up-regulation of hemocyte proliferation" EXACT [] synonym: "upregulation of hemocyte proliferation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0035206 ! regulation of hemocyte proliferation relationship: positively_regulates GO:0035172 ! hemocyte proliferation [Term] id: GO:0035209 name: pupal development namespace: biological_process def: "The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu] is_a: GO:0002165 ! instar larval or pupal development [Term] id: GO:0035210 name: prepupal development namespace: biological_process def: "The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm] comment: See also the fly_anatomy.ontology term 'prepupa ; FBbt:00002952'. is_a: GO:0002165 ! instar larval or pupal development [Term] id: GO:0035211 name: spermathecum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097] comment: See also the fly_anatomy.ontology term 'spermathecum ; FBbt:00004921'. is_a: GO:0009887 ! organ morphogenesis [Term] id: GO:0035212 name: cell competition in a multicellular organism namespace: biological_process def: "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286] is_a: GO:0009987 ! cellular process is_a: GO:0040008 ! regulation of growth relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0035213 name: clypeo-labral disc development namespace: biological_process def: "The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite." [GOC:bf, ISBN:0879694238] synonym: "development of structures derived from the clypeo-labral disc" EXACT [] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035214 name: eye-antennal disc development namespace: biological_process def: "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035215 name: genital disc development namespace: biological_process def: "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035216 name: haltere disc development namespace: biological_process def: "Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035217 name: labial disc development namespace: biological_process def: "Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035218 name: leg disc development namespace: biological_process def: "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035219 name: prothoracic disc development namespace: biological_process def: "Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035220 name: wing disc development namespace: biological_process def: "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035221 name: genital disc pattern formation namespace: biological_process def: "The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc." [GOC:bf] is_a: GO:0007447 ! imaginal disc pattern formation relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0035222 name: wing disc pattern formation namespace: biological_process def: "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf] is_a: GO:0007447 ! imaginal disc pattern formation relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0035223 name: leg disc pattern formation namespace: biological_process def: "The process that gives rise to the patterns of cell differentiation in the leg imaginal disc." [GOC:bf] is_a: GO:0007447 ! imaginal disc pattern formation relationship: part_of GO:0035218 ! leg disc development [Term] id: GO:0035224 name: genital disc anterior/posterior pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318] is_a: GO:0007448 ! anterior/posterior pattern formation, imaginal disc is_a: GO:0035221 ! genital disc pattern formation [Term] id: GO:0035225 name: determination of genital disc primordium namespace: biological_process def: "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318] is_a: GO:0007445 ! determination of imaginal disc primordium relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0035226 name: glutamate-cysteine ligase catalytic subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase." [PMID:12954617] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0035227 name: regulation of glutamate-cysteine ligase activity namespace: biological_process def: "Any process that modulates the activity of glutamate-cysteine ligase." [GOC:bf] subset: gosubset_prok is_a: GO:0051340 ! regulation of ligase activity [Term] id: GO:0035228 name: negative regulation of glutamate-cysteine ligase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase." [GOC:bf] subset: gosubset_prok synonym: "down regulation of glutamate-cysteine ligase activity" EXACT [] synonym: "down-regulation of glutamate-cysteine ligase activity" EXACT [] synonym: "downregulation of glutamate-cysteine ligase activity" EXACT [] synonym: "inhibition of glutamate-cysteine ligase activity" NARROW [] is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity is_a: GO:0051352 ! negative regulation of ligase activity [Term] id: GO:0035229 name: positive regulation of glutamate-cysteine ligase activity namespace: biological_process def: "Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate." [PMID:12954617] subset: gosubset_prok synonym: "activation of glutamate-cysteine ligase activity" NARROW [] synonym: "stimulation of glutamate-cysteine ligase activity" NARROW [] synonym: "up regulation of glutamate-cysteine ligase activity" EXACT [] synonym: "up-regulation of glutamate-cysteine ligase activity" EXACT [] synonym: "upregulation of glutamate-cysteine ligase activity" EXACT [] is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity is_a: GO:0051351 ! positive regulation of ligase activity [Term] id: GO:0035230 name: cytoneme namespace: cellular_component def: "A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901] subset: goslim_pir synonym: "membrane nanotube" EXACT [Wikipedia:Membrane_nanotube] xref: Wikipedia:Membrane_nanotube is_a: GO:0042995 ! cell projection [Term] id: GO:0035231 name: cytoneme assembly namespace: biological_process def: "Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [PMID:10367889, PMID:10675901] synonym: "cytoneme biogenesis" RELATED [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0030031 ! cell projection assembly relationship: part_of GO:0003399 ! cytoneme morphogenesis [Term] id: GO:0035232 name: germ cell attraction namespace: biological_process def: "The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target." [PMID:12885551] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0050918 ! positive chemotaxis is_a: GO:0060326 ! cell chemotaxis relationship: part_of GO:0008354 ! germ cell migration [Term] id: GO:0035233 name: germ cell repulsion namespace: biological_process def: "The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue." [PMID:12885551] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0050919 ! negative chemotaxis is_a: GO:0060326 ! cell chemotaxis relationship: part_of GO:0008354 ! germ cell migration [Term] id: GO:0035234 name: germ cell programmed cell death namespace: biological_process def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] synonym: "programmed cell death of germ cells" EXACT [] synonym: "programmed cell death, germ cells" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! developmental programmed cell death is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0008354 ! germ cell migration [Term] id: GO:0035235 name: ionotropic glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor, followed by the movement of ions through a channel in the receptor complex." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ionotropic glutamate receptor signalling pathway" EXACT [] is_a: GO:0007215 ! glutamate signaling pathway [Term] id: GO:0035236 name: proctolin receptor activity namespace: molecular_function def: "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0035237 name: corazonin receptor activity namespace: molecular_function def: "Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0035238 name: vitamin A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606] subset: gosubset_prok synonym: "vitamin A anabolism" EXACT [] synonym: "vitamin A biosynthesis" EXACT [] synonym: "vitamin A formation" EXACT [] synonym: "vitamin A synthesis" EXACT [] is_a: GO:0006776 ! vitamin A metabolic process is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process [Term] id: GO:0035239 name: tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0035295 ! tube development [Term] id: GO:0035240 name: dopamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0043176 ! amine binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0035241 name: protein-arginine omega-N monomethyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue." [PMID:14705965, RESID:AA0069] xref: RESID:AA0069 is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0035242 name: protein-arginine omega-N asymmetric methyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965, RESID:AA0068, RESID:AA0069] comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'. synonym: "type I PRMT activity" RELATED [] synonym: "type I protein arginine methyltransferase activity" RELATED [] xref: RESID:AA0068 xref: RESID:AA0069 is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0035243 name: protein-arginine omega-N symmetric methyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [PMID:14705965, RESID:AA0067, RESID:AA0069] comment: Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'. synonym: "type II PRMT activity" RELATED [] synonym: "type II protein arginine methyltransferase activity" RELATED [] xref: RESID:AA0067 xref: RESID:AA0069 is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0035244 name: peptidyl-arginine C-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein." [GOC:bf] is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0035245 name: peptidyl-arginine C-methylation namespace: biological_process def: "The addition of a methyl group onto a carbon atom of an arginine residue in a protein." [GOC:bf] subset: gosubset_prok is_a: GO:0018216 ! peptidyl-arginine methylation [Term] id: GO:0035246 name: peptidyl-arginine N-methylation namespace: biological_process def: "The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein." [GOC:bf] subset: gosubset_prok is_a: GO:0018216 ! peptidyl-arginine methylation [Term] id: GO:0035247 name: peptidyl-arginine omega-N-methylation namespace: biological_process def: "The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein." [PMID:14705965, RESID:AA0067, RESID:AA0068, RESID:AA0069] subset: gosubset_prok xref: RESID:AA0067 xref: RESID:AA0068 xref: RESID:AA0069 is_a: GO:0035246 ! peptidyl-arginine N-methylation [Term] id: GO:0035248 name: alpha-1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086] synonym: "alpha-1,4-GalNAc transferase activity" EXACT [] is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0035249 name: synaptic transmission, glutamatergic namespace: biological_process def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv] is_a: GO:0007270 ! neuron-neuron synaptic transmission [Term] id: GO:0035250 name: UDP-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] subset: gosubset_prok is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0035251 name: UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] subset: gosubset_prok xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0035252 name: UDP-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0042285 ! xylosyltransferase activity [Term] id: GO:0035253 name: ciliary rootlet namespace: cellular_component def: "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [PMID:12427867] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044441 ! cilium part [Term] id: GO:0035254 name: glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glutamate receptor." [GOC:bf] is_a: GO:0005102 ! receptor binding [Term] id: GO:0035255 name: ionotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0035254 ! glutamate receptor binding [Term] id: GO:0035256 name: metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a metabotropic glutamate receptor. Metabotropic glutamate receptors are G-protein coupled receptors that bind glutamate and exert an effect through the regulation of enzyme activity." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:9069287] is_a: GO:0001664 ! G-protein-coupled receptor binding is_a: GO:0035254 ! glutamate receptor binding [Term] id: GO:0035257 name: nuclear hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell." [GOC:bf] is_a: GO:0051427 ! hormone receptor binding [Term] id: GO:0035258 name: steroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a steroid hormone receptor." [GOC:bf] is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0035259 name: glucocorticoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glucocorticoid receptor." [GOC:bf] is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0035260 name: internal genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [http://www.ndif.org/Terms/genitalia.html] is_a: GO:0035112 ! genitalia morphogenesis [Term] id: GO:0035261 name: external genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [http://www.ndif.org/Terms/genitalia.html] is_a: GO:0035112 ! genitalia morphogenesis [Term] id: GO:0035262 name: gonad morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0008406 ! gonad development [Term] id: GO:0035263 name: genital disc sexually dimorphic development namespace: biological_process def: "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007548 ! sex differentiation relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0035264 name: multicellular organism growth namespace: biological_process def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] synonym: "body growth" RELATED [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0040007 ! growth [Term] id: GO:0035265 name: organ growth namespace: biological_process def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0040007 ! growth [Term] id: GO:0035266 name: meristem growth namespace: biological_process def: "The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:bf, ISBN:0198547684] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0035267 name: NuA4 histone acetyltransferase complex namespace: cellular_component def: "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] synonym: "TIP60 histone acetylase complex" EXACT [] synonym: "TIP60 histone acetyltransferase complex" EXACT [] is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex [Term] id: GO:0035268 name: protein mannosylation namespace: biological_process def: "The addition of a mannose residue to a protein acceptor molecule." [GOC:bf] subset: gosubset_prok synonym: "protein amino acid mannosylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0035269 name: protein O-linked mannosylation namespace: biological_process def: "The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797] subset: gosubset_prok synonym: "protein amino acid O-linked mannosylation" EXACT [GOC:bf] is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0035268 ! protein mannosylation [Term] id: GO:0035270 name: endocrine system development namespace: biological_process def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, http://encyclopedia.thefreedictionary.com/Endocrine+sytem, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048731 ! system development [Term] id: GO:0035271 name: ring gland development namespace: biological_process def: "Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098] comment: See also the fly_anatomy.ontology terms 'ring gland ; FBbt:00001722, 'prothoracic gland ; FBbt:00001724', 'corpus allatum ; FBbt:00005800' and 'corpus cardiacum ; FBbt:00005799. is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0035272 name: exocrine system development namespace: biological_process def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, http://encyclopedia.thefreedictionary.com/Exocrine+gland, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048731 ! system development [Term] id: GO:0035273 name: phthalate binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phthalate, any ester or salt of phthalic acid." [http://umbbd.ahc.umn.edu/pth/pth_map.html] subset: goslim_pir subset: gosubset_prok is_a: GO:0043168 ! anion binding [Term] id: GO:0035274 name: diphenyl phthalate binding namespace: molecular_function def: "Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com] synonym: "DPP binding" EXACT [] is_a: GO:0035273 ! phthalate binding [Term] id: GO:0035275 name: dibutyl phthalate binding namespace: molecular_function def: "Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com] synonym: "DBP binding" EXACT [] synonym: "phthalic acid dibutyl ester binding" EXACT [] is_a: GO:0035273 ! phthalate binding [Term] id: GO:0035276 name: ethanol binding namespace: molecular_function def: "Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0043178 ! alcohol binding [Term] id: GO:0035277 name: spiracle morphogenesis, open tracheal system namespace: biological_process def: "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] synonym: "spiracle morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035278 name: negative regulation of translation involved in gene silencing by miRNA namespace: biological_process def: "The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically repress translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs." [PMID:14744438, PMID:15196554] synonym: "down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah] synonym: "down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah] synonym: "downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah] synonym: "gene silencing by miRNA, negative regulation of translation" EXACT [GOC:mah] synonym: "inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:mah] synonym: "miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:dph, GOC:tb] is_a: GO:0040033 ! negative regulation of translation, ncRNA-mediated relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035279 name: mRNA cleavage involved in gene silencing by miRNA namespace: biological_process def: "The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically direct cleavage by base pairing with near-perfect complementarity to the target mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554] synonym: "gene silencing by miRNA, mRNA cleavage" EXACT [GOC:mah] synonym: "miRNA-mediated gene silencing, mRNA cleavage" EXACT [GOC:dph, GOC:tb] is_a: GO:0006379 ! mRNA cleavage relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035280 name: miRNA loading onto RISC involved in gene silencing by miRNA namespace: biological_process def: "The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC)." [PMID:14744438] synonym: "gene silencing by miRNA, miRNA loading onto RISC" EXACT [GOC:mah] synonym: "miRISC assembly" BROAD [] synonym: "miRNA-mediated gene silencing, miRNA loading onto RISC" EXACT [GOC:dph, GOC:tb] is_a: GO:0070922 ! small RNA loading onto RISC relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035281 name: pre-microRNA export from nucleus namespace: biological_process def: "Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product." [PMID:14744438] synonym: "pre-microRNA export from cell nucleus" EXACT [] synonym: "pre-microRNA export out of nucleus" EXACT [] synonym: "pre-microRNA transport from nucleus to cytoplasm" EXACT [] synonym: "pre-microRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035282 name: segmentation namespace: biological_process def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] xref: Wikipedia:Segmentation_(biology) is_a: GO:0003002 ! regionalization [Term] id: GO:0035283 name: central nervous system segmentation namespace: biological_process def: "Division of the central nervous system into a series of semi-repetitive parts or segments." [GOC:bf] is_a: GO:0035282 ! segmentation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0035284 name: brain segmentation namespace: biological_process def: "Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf] is_a: GO:0035282 ! segmentation relationship: part_of GO:0007420 ! brain development relationship: part_of GO:0035283 ! central nervous system segmentation [Term] id: GO:0035285 name: appendage segmentation namespace: biological_process def: "Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented." [PMID:10357895] is_a: GO:0035282 ! segmentation relationship: part_of GO:0035107 ! appendage morphogenesis [Term] id: GO:0035286 name: leg segmentation namespace: biological_process def: "Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint." [PMID:10357895] is_a: GO:0035285 ! appendage segmentation relationship: part_of GO:0035110 ! leg morphogenesis [Term] id: GO:0035287 name: head segmentation namespace: biological_process def: "Partitioning the head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial)." [PMID:10477305, PMID:7915837] comment: See also the fly_anatomy.ontology term 'head segment ; FBbt:00000006' and its children. is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0035288 name: anterior head segmentation namespace: biological_process def: "Partitioning the head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136] comment: See also the fly_anatomy.ontology term 'procephalic segment ; FBbt:00000007' and its children. synonym: "procephalic segmentation" RELATED [] is_a: GO:0035287 ! head segmentation [Term] id: GO:0035289 name: posterior head segmentation namespace: biological_process def: "Partitioning the posterior region of the head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136] comment: See also the fly_anatomy.ontology term 'gnathal segment ; FBbt:00000011' and its children. synonym: "gnathal segmentation" RELATED [] is_a: GO:0035287 ! head segmentation [Term] id: GO:0035290 name: trunk segmentation namespace: biological_process def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402] is_a: GO:0035282 ! segmentation relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0035291 name: specification of segmental identity, intercalary segment namespace: biological_process def: "The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437, PMID:10477305] comment: See also the fly_anatomy.ontology term 'intercalary segment ; FBbt:00000010'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035288 ! anterior head segmentation [Term] id: GO:0035292 name: specification of segmental identity, trunk namespace: biological_process def: "The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [PMID:1360402] is_a: GO:0007379 ! segment specification relationship: part_of GO:0035290 ! trunk segmentation [Term] id: GO:0035293 name: chitin-based larval cuticle pattern formation namespace: biological_process def: "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0035017 ! cuticle pattern formation relationship: part_of GO:0008363 ! larval chitin-based cuticle development [Term] id: GO:0035294 name: determination of wing disc primordium namespace: biological_process def: "Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc." [ISBN:0879694238] is_a: GO:0007445 ! determination of imaginal disc primordium is_a: GO:0035220 ! wing disc development [Term] id: GO:0035295 name: tube development namespace: biological_process def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0035296 name: regulation of tube diameter namespace: biological_process def: "Ensuring that a tube is the correct width." [GOC:bf] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0035150 ! regulation of tube size [Term] id: GO:0035297 name: regulation of Malpighian tubule diameter namespace: biological_process def: "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684] is_a: GO:0035296 ! regulation of tube diameter relationship: part_of GO:0035298 ! regulation of Malpighian tubule size [Term] id: GO:0035298 name: regulation of Malpighian tubule size namespace: biological_process def: "Ensuring that a Malpighian tubule is the correct length and diameter." [GOC:bf] is_a: GO:0035150 ! regulation of tube size relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis [Term] id: GO:0035299 name: inositol pentakisphosphate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [EC:2.7.1.158, RHEA:20316] synonym: "ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.158] synonym: "Gsl1p" RELATED [EC:2.7.1.158] synonym: "inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "inositol polyphosphate kinase activity" EXACT [EC:2.7.1.158] synonym: "inositol-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "Ins(1,3,4,5,6)P5 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "IP5 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "Ipk1p" RELATED [EC:2.7.1.158] xref: EC:2.7.1.158 xref: KEGG:R05202 xref: MetaCyc:RXN-7163 xref: RHEA:20316 is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0035300 name: inositol-1,3,4-trisphosphate 5/6-kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate, and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate." [EC:2.7.1.159, PMID:9126335] synonym: "ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.159] synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" NARROW [] synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" NARROW [] synonym: "inositol trisphosphate 5/6-kinase activity" EXACT [EC:2.7.1.159] synonym: "Ins(1,3,4)P3 5/6-kinase activity" EXACT [EC:2.7.1.159] synonym: "IP56K" RELATED [EC:2.7.1.159] xref: EC:2.7.1.159 xref: MetaCyc:2.7.1.133-RXN xref: Reactome:161149 "inositol-1,3,4-trisphosphate 5/6-kinase activity" is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0035301 name: Hedgehog signaling complex namespace: cellular_component def: "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936] synonym: "Hedgehog signalling complex" EXACT [] synonym: "HSC" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0035302 name: ecdysteroid 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:15350618] comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol). is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0035303 name: regulation of dephosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] subset: gosubset_prok is_a: GO:0019220 ! regulation of phosphate metabolic process relationship: regulates GO:0016311 ! dephosphorylation [Term] id: GO:0035304 name: regulation of protein dephosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] subset: gosubset_prok synonym: "regulation of protein amino acid dephosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0035303 ! regulation of dephosphorylation relationship: regulates GO:0006470 ! protein dephosphorylation [Term] id: GO:0035305 name: negative regulation of dephosphorylation namespace: biological_process def: "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] subset: gosubset_prok synonym: "down regulation of dephosphorylation" EXACT [] synonym: "down-regulation of dephosphorylation" EXACT [] synonym: "downregulation of dephosphorylation" EXACT [] synonym: "inhibition of dephosphorylation" NARROW [] is_a: GO:0035303 ! regulation of dephosphorylation is_a: GO:0045936 ! negative regulation of phosphate metabolic process relationship: negatively_regulates GO:0016311 ! dephosphorylation [Term] id: GO:0035306 name: positive regulation of dephosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] subset: gosubset_prok synonym: "activation of dephosphorylation" NARROW [] synonym: "stimulation of dephosphorylation" NARROW [] synonym: "up regulation of dephosphorylation" EXACT [] synonym: "up-regulation of dephosphorylation" EXACT [] synonym: "upregulation of dephosphorylation" EXACT [] is_a: GO:0035303 ! regulation of dephosphorylation is_a: GO:0045937 ! positive regulation of phosphate metabolic process relationship: positively_regulates GO:0016311 ! dephosphorylation [Term] id: GO:0035307 name: positive regulation of protein dephosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] subset: gosubset_prok synonym: "activation of protein amino acid dephosphorylation" NARROW [] synonym: "positive regulation of protein amino acid dephosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid dephosphorylation" NARROW [] synonym: "up regulation of protein amino acid dephosphorylation" EXACT [] synonym: "up-regulation of protein amino acid dephosphorylation" EXACT [] synonym: "upregulation of protein amino acid dephosphorylation" EXACT [] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0035304 ! regulation of protein dephosphorylation is_a: GO:0035306 ! positive regulation of dephosphorylation relationship: positively_regulates GO:0006470 ! protein dephosphorylation [Term] id: GO:0035308 name: negative regulation of protein dephosphorylation namespace: biological_process def: "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] subset: gosubset_prok synonym: "down regulation of protein amino acid dephosphorylation" EXACT [] synonym: "down-regulation of protein amino acid dephosphorylation" EXACT [] synonym: "downregulation of protein amino acid dephosphorylation" EXACT [] synonym: "inhibition of protein amino acid dephosphorylation" NARROW [] synonym: "negative regulation of protein amino acid dephosphorylation" EXACT [GOC:bf] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0035304 ! regulation of protein dephosphorylation is_a: GO:0035305 ! negative regulation of dephosphorylation relationship: negatively_regulates GO:0006470 ! protein dephosphorylation [Term] id: GO:0035309 name: wing and notum subfield formation namespace: biological_process def: "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999] is_a: GO:0003002 ! regionalization relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0035310 name: notum cell fate specification namespace: biological_process def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0035309 ! wing and notum subfield formation [Term] id: GO:0035311 name: wing cell fate specification namespace: biological_process def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0035309 ! wing and notum subfield formation [Term] id: GO:0035312 name: 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684] is_a: GO:0008409 ! 5'-3' exonuclease activity is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0035313 name: wound healing, spreading of epidermal cells namespace: biological_process def: "The migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis." [GOC:bf, PMID:15269788] is_a: GO:0044319 ! wound healing, spreading of cells [Term] id: GO:0035314 name: scab formation namespace: biological_process def: "Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0035315 name: hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf] is_a: GO:0009913 ! epidermal cell differentiation [Term] id: GO:0035316 name: non-sensory hair organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425] comment: See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'. synonym: "non-sensory hair organization and biogenesis" RELATED [GOC:mah] synonym: "trichome organisation" BROAD [] synonym: "trichome organization and biogenesis" BROAD [] is_a: GO:0030030 ! cell projection organization relationship: part_of GO:0035315 ! hair cell differentiation [Term] id: GO:0035317 name: imaginal disc-derived wing hair organization namespace: biological_process def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] comment: See also the fly_anatomy.ontology term 'wing hair ; FBbt:00004340'. synonym: "imaginal disc-derived wing hair organization and biogenesis" RELATED [GOC:mah] synonym: "wing hair organisation" EXACT [GOC:curators] synonym: "wing hair organization and biogenesis" RELATED [GOC:mah] synonym: "wing trichome organization and biogenesis" EXACT [] is_a: GO:0035316 ! non-sensory hair organization relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0035318 name: imaginal disc-derived wing hair outgrowth namespace: biological_process def: "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551] synonym: "wing hair outgrowth" EXACT [] synonym: "wing prehair outgrowth" RELATED [] is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0048858 ! cell projection morphogenesis relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0035319 name: imaginal disc-derived wing hair elongation namespace: biological_process def: "Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles." [GOC:mtg_sensu, PMID:11832234] synonym: "wing hair elongation" EXACT [] synonym: "wing prehair extension" RELATED [] is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0048858 ! cell projection morphogenesis relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0035320 name: imaginal disc-derived wing hair site selection namespace: biological_process def: "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551] synonym: "prehair localization" RELATED [] synonym: "wing hair site selection" EXACT [] is_a: GO:0022606 ! establishment of proximal/distal cell polarity relationship: part_of GO:0001737 ! establishment of imaginal disc-derived wing hair orientation [Term] id: GO:0035321 name: maintenance of imaginal disc-derived wing hair orientation namespace: biological_process def: "Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity." [GOC:mtg_sensu, PMID:15501220] synonym: "maintenance of wing hair orientation" EXACT [] is_a: GO:0009954 ! proximal/distal pattern formation relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0035322 name: mesenchymal cell migration involved in limb bud formation namespace: biological_process def: "The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud." [GOC:dgh] is_a: GO:0090131 ! mesenchyme migration relationship: part_of GO:0060174 ! limb bud formation [Term] id: GO:0035323 name: male germline ring canal namespace: cellular_component def: "An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420] synonym: "spermatocyte ring canal" NARROW [] synonym: "testicular ring canal" NARROW [] is_a: GO:0045172 ! germline ring canal [Term] id: GO:0035324 name: female germline ring canal namespace: cellular_component def: "An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420] synonym: "nurse cell ring canal" NARROW [] synonym: "ovarian ring canal" NARROW [] is_a: GO:0045172 ! germline ring canal [Term] id: GO:0035325 name: Toll-like receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response." [PMID:19076341] synonym: "TLR binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0035326 name: enhancer binding namespace: molecular_function def: "Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:sart, GOC:txnOH, SO:0000165] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0035327 name: transcriptionally active chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] is_a: GO:0000785 ! chromatin [Term] id: GO:0035328 name: transcriptionally silent chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are not being actively transcribed." [GOC:sart, PMID:17965872] synonym: "transcriptionally inactive chromatin" EXACT [] is_a: GO:0000785 ! chromatin [Term] id: GO:0035329 name: hippo signaling cascade namespace: biological_process def: "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423] synonym: "hippo signaling pathway" EXACT [] synonym: "hippo signalling cascade" EXACT [GOC:mah] synonym: "Salvador-Warts-Hippo signaling pathway" NARROW [] synonym: "SWH pathway" NARROW [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0035330 name: regulation of hippo signaling cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf] synonym: "regulation of hippo signaling pathway" EXACT [] synonym: "regulation of hippo signalling cascade" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0035329 ! hippo signaling cascade [Term] id: GO:0035331 name: negative regulation of hippo signaling cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf] synonym: "negative regulation of hippo signaling pathway" EXACT [] synonym: "negative regulation of hippo signalling cascade" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0035330 ! regulation of hippo signaling cascade relationship: negatively_regulates GO:0035329 ! hippo signaling cascade [Term] id: GO:0035332 name: positive regulation of hippo signaling cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf] synonym: "positive regulation of hippo signaling pathway" EXACT [] synonym: "positive regulation of hippo signalling cascade" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0035330 ! regulation of hippo signaling cascade relationship: positively_regulates GO:0035329 ! hippo signaling cascade [Term] id: GO:0035333 name: Notch receptor processing, ligand-dependent namespace: biological_process def: "The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD)." [GOC:bf, PMID:12651094] synonym: "Notch S2 cleavage" NARROW [PMID:12651094] synonym: "Notch S3 cleavage" NARROW [PMID:12651094] is_a: GO:0031293 ! membrane protein intracellular domain proteolysis relationship: part_of GO:0007219 ! Notch signaling pathway relationship: part_of GO:0007220 ! Notch receptor processing [Term] id: GO:0035334 name: Notch receptor processing, ligand-independent namespace: biological_process def: "The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface." [GOC:bf, PMID:12651094] synonym: "Notch S1 cleavage" NARROW [PMID:12651094] is_a: GO:0051605 ! protein maturation by peptide bond cleavage relationship: part_of GO:0007220 ! Notch receptor processing [Term] id: GO:0035335 name: peptidyl-tyrosine dephosphorylation namespace: biological_process def: "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] is_a: GO:0006470 ! protein dephosphorylation [Term] id: GO:0035336 name: long-chain fatty-acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths ranging from C12-18." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "long-chain fatty acyl CoA metabolic process" EXACT [GOC:curators] synonym: "long-chain fatty acyl-CoA metabolism" EXACT [] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process [Term] id: GO:0035337 name: fatty-acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "fatty acyl CoA metabolic process" EXACT [GOC:curators] synonym: "fatty-acyl-CoA metabolism" EXACT [] is_a: GO:0006637 ! acyl-CoA metabolic process [Term] id: GO:0035338 name: long-chain fatty-acyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths ranging from C12-18." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "long-chain fatty acyl CoA biosynthetic process" EXACT [GOC:curators] synonym: "long-chain fatty-acyl-CoA anabolism" EXACT [] synonym: "long-chain fatty-acyl-CoA biosynthesis" EXACT [] synonym: "long-chain fatty-acyl-CoA formation" EXACT [] synonym: "long-chain fatty-acyl-CoA synthesis" EXACT [] xref: Reactome:1253062 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1253072 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1279998 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1280007 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1298891 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1298897 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1326568 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1326577 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1352680 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1352689 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1372896 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1372906 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1392914 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1392921 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1417389 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1417659 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1450487 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1450496 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1471000 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1471009 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1483025 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1483035 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1496793 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1496802 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1514183 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1514192 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1521019 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1526757 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1526765 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1532488 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1532496 "Synthesis of very long-chain fatty acyl-CoAs" xref: Reactome:1536100 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:1539268 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:75105 "Fatty Acyl-CoA Biosynthesis" xref: Reactome:75876 "Synthesis of very long-chain fatty acyl-CoAs" is_a: GO:0035336 ! long-chain fatty-acyl-CoA metabolic process is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process [Term] id: GO:0035339 name: SPOTS complex namespace: cellular_component def: "A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis." [PMID:20182505] synonym: "serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex" NARROW [] is_a: GO:0017059 ! serine C-palmitoyltransferase complex [Term] id: GO:0035340 name: inosine transport namespace: biological_process def: "The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17596, PMID:19135251] synonym: "hypoxanthine riboside transport" EXACT [] is_a: GO:0015860 ! purine nucleoside transport [Term] id: GO:0035341 name: regulation of inosine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "regulation of hypoxanthine riboside transport" EXACT [] is_a: GO:0032245 ! regulation of purine nucleoside transport relationship: regulates GO:0035340 ! inosine transport [Term] id: GO:0035342 name: positive regulation of inosine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "positive regulation of hypoxanthine riboside transport" EXACT [] is_a: GO:0032248 ! positive regulation of purine nucleoside transport is_a: GO:0035341 ! regulation of inosine transport relationship: positively_regulates GO:0035340 ! inosine transport [Term] id: GO:0035343 name: negative regulation of inosine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "negative regulation of hypoxanthine riboside transport" EXACT [] is_a: GO:0032247 ! negative regulation of purine nucleoside transport is_a: GO:0035341 ! regulation of inosine transport relationship: negatively_regulates GO:0035340 ! inosine transport [Term] id: GO:0035344 name: hypoxanthine transport namespace: biological_process def: "The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17368, GOC:sl] synonym: "6-hydroxypurine transport" EXACT [] synonym: "hypoxanthine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine base transport [Term] id: GO:0035345 name: regulation of hypoxanthine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "regulation of 6-hydroxypurine transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0034762 ! regulation of transmembrane transport relationship: regulates GO:0035344 ! hypoxanthine transport [Term] id: GO:0035346 name: positive regulation of hypoxanthine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "positive regulation of 6-hydroxypurine transport" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0035345 ! regulation of hypoxanthine transport relationship: positively_regulates GO:0035344 ! hypoxanthine transport [Term] id: GO:0035347 name: negative regulation of hypoxanthine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "negative regulation of 6-hydroxypurine transport" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0035345 ! regulation of hypoxanthine transport relationship: negatively_regulates GO:0035344 ! hypoxanthine transport [Term] id: GO:0035348 name: acetyl-CoA transmembrane transport namespace: biological_process def: "The process in which acetyl-CoA is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GO:bf] is_a: GO:0015876 ! acetyl-CoA transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035349 name: coenzyme A transmembrane transport namespace: biological_process def: "The process in which coenzyme A is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:bf] is_a: GO:0015880 ! coenzyme A transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035350 name: FAD transmembrane transport namespace: biological_process def: "The process in which flavin-adenine dinucleotide (FAD) is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015883 ! FAD transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035351 name: heme transmembrane transport namespace: biological_process def: "The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:bf] is_a: GO:0015886 ! heme transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035352 name: NAD transmembrane transport namespace: biological_process def: "The process in which nicotinamide adenine dinucleotide is transported from one side of a membrane to the other by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:bf] is_a: GO:0043132 ! NAD transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035353 name: nicotinamide mononucleotide transmembrane transport namespace: biological_process def: "The process in which nicotinamide mononucleotide is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [GOC:bf, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0015890 ! nicotinamide mononucleotide transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035354 name: Toll-like receptor 1-Toll-like receptor 2 protein complex namespace: cellular_component def: "A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2)." [GOC:add, PMID:17889651] synonym: "TLR1-TLR2 protein complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0035355 name: Toll-like receptor 2-Toll-like receptor 6 protein complex namespace: cellular_component def: "A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6)." [GOC:add, PMID:19931471] synonym: "TLR2-TLR6 protein complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0035356 name: cellular triglyceride homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment." [GOC:BHF] is_a: GO:0055082 ! cellular chemical homeostasis is_a: GO:0070328 ! triglyceride homeostasis [Term] id: GO:0035357 name: peroxisome proliferator activated receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes." [GOC:BHF, PMID:18221086] synonym: "peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] synonym: "peroxisome proliferator-activated receptor signaling pathway" EXACT [] synonym: "PPAR signaling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0035358 name: regulation of peroxisome proliferator activated receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf] synonym: "regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT [] synonym: "regulation of PPAR signaling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway [Term] id: GO:0035359 name: negative regulation of peroxisome proliferator activated receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf] synonym: "negative regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT [] synonym: "negative regulation of PPAR signaling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway relationship: negatively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway [Term] id: GO:0035360 name: positive regulation of peroxisome proliferator activated receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf] synonym: "positive regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT [] synonym: "positive regulation of PPAR signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway relationship: positively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway [Term] id: GO:0035361 name: Cul8-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins." [GOC:krc, PMID:20139071] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0035362 name: protein-DNA ISRE complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA." [GOC:amm, PMID:11747630] synonym: "protein-DNA interferon-stimulated response element complex assembly" EXACT [] is_a: GO:0065004 ! protein-DNA complex assembly [Term] id: GO:0035363 name: histone locus body namespace: cellular_component def: "A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235] synonym: "HLB" EXACT [PMID:16533947, PMID:18927579, PMID:19620235] is_a: GO:0016604 ! nuclear body [Term] id: GO:0035364 name: thymine transport namespace: biological_process def: "The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO:sl] synonym: "5-methyluracil transport" EXACT [CHEBI:17821] synonym: "thymine transmembrane transport" EXACT [GOC:mah] is_a: GO:0015855 ! pyrimidine base transport [Term] id: GO:0035365 name: regulation of thymine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl] synonym: "regulation of 5-methyluracil transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0034762 ! regulation of transmembrane transport relationship: regulates GO:0035364 ! thymine transport [Term] id: GO:0035366 name: negative regulation of thymine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl] synonym: "negative regulation of 5-methyluracil transport" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0035365 ! regulation of thymine transport relationship: negatively_regulates GO:0035364 ! thymine transport [Term] id: GO:0035367 name: positive regulation of thymine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl] synonym: "positive regulation of 5-methyluracil transport" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0035365 ! regulation of thymine transport relationship: positively_regulates GO:0035364 ! thymine transport [Term] id: GO:0035368 name: selenocysteine insertion sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation." [GOC:imk, PMID:10760958] synonym: "SECIS binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0035369 name: pre-B cell receptor complex namespace: cellular_component def: "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16464608, PMID:17306522] comment: Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome. synonym: "pre-BCR" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part [Term] id: GO:0035370 name: UBC13-UEV1A complex namespace: cellular_component def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A)." [GOC:amm, PMID:16129784] is_a: GO:0031371 ! ubiquitin conjugating enzyme complex [Term] id: GO:0035371 name: microtubule plus end namespace: cellular_component def: "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273] synonym: "growing microtubule plus end" EXACT [] synonym: "microtubule plus-end" EXACT [] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005874 ! microtubule [Term] id: GO:0035372 name: protein localization to microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb] synonym: "protein localisation to microtubule" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0035373 name: chondroitin sulfate proteoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit." [GOC:kmv, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0043394 ! proteoglycan binding [Term] id: GO:0035374 name: chondroitin sulfate binding namespace: molecular_function def: "Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)." [GOC:kmv, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005539 ! glycosaminoglycan binding [Term] id: GO:0035375 name: zymogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "proenzyme binding" NARROW [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0035376 name: sterol import namespace: biological_process def: "The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, PMID:19793923] is_a: GO:0035382 ! sterol transmembrane transport [Term] id: GO:0035377 name: transepithelial water transport namespace: biological_process def: "The directed movement of water (H2O) from one side of an epithelium to the other." [GOC:yaf] is_a: GO:0006833 ! water transport is_a: GO:0042045 ! epithelial fluid transport is_a: GO:0070633 ! transepithelial transport [Term] id: GO:0035378 name: carbon dioxide transmembrane transport namespace: biological_process def: "A process in which carbon dioxide (CO2) is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:yaf] is_a: GO:0015670 ! carbon dioxide transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035379 name: carbon dioxide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other." [GOC:yaf] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0035380 name: very long-chain-3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. Very-long-chain fatty acids have a chain length of greater than 18 carbons." [GOC:pde] synonym: "very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [] xref: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0035381 name: ATP-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf] is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0035382 name: sterol transmembrane transport namespace: biological_process def: "The directed movement of a sterol across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:vw] is_a: GO:0015918 ! sterol transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035383 name: thioester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [CHEBI:51277, GOC:bf, http://encyclopedia.thefreedictionary.com/Thioester] synonym: "thioester metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0035384 name: thioester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [CHEBI:51277, GOC:bf, http://encyclopedia.thefreedictionary.com/Thioester] synonym: "thioester anabolism" EXACT [] synonym: "thioester biosynthesis" EXACT [] synonym: "thioester formation" EXACT [] synonym: "thioester synthesis" EXACT [] is_a: GO:0035383 ! thioester metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0035385 name: Roundabout signaling pathway namespace: biological_process def: "The series of molecular signals generated by binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of the target cell." [GOC:BHF] synonym: "ROBO signaling pathway" EXACT [] synonym: "ROBO/SLIT signaling pathway" EXACT [] synonym: "Roundabout signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0035386 name: regulation of Roundabout signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF] synonym: "regulation of Roundabout signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0035385 ! Roundabout signaling pathway [Term] id: GO:0035387 name: negative regulation of Roundabout signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF] synonym: "negative regulation of Roundabout signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0035386 ! regulation of Roundabout signaling pathway relationship: negatively_regulates GO:0035385 ! Roundabout signaling pathway [Term] id: GO:0035388 name: positive regulation of Roundabout signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF] synonym: "positive regulation of Roundabout signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0035386 ! regulation of Roundabout signaling pathway relationship: positively_regulates GO:0035385 ! Roundabout signaling pathway [Term] id: GO:0035389 name: establishment of chromatin silencing at silent mating-type cassette namespace: biological_process def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at silent mating-type loci." [GOC:vw] is_a: GO:0006343 ! establishment of chromatin silencing relationship: part_of GO:0030466 ! chromatin silencing at silent mating-type cassette [Term] id: GO:0035390 name: establishment of chromatin silencing at telomere namespace: biological_process def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at the telomere." [GOC:vw] is_a: GO:0006343 ! establishment of chromatin silencing relationship: part_of GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0035391 name: maintenance of chromatin silencing at silent mating-type cassette namespace: biological_process def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at silent mating-type loci." [GOC:vw] is_a: GO:0006344 ! maintenance of chromatin silencing relationship: part_of GO:0030466 ! chromatin silencing at silent mating-type cassette [Term] id: GO:0035392 name: maintenance of chromatin silencing at telomere namespace: biological_process def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at the telomere." [GOC:vw] is_a: GO:0006344 ! maintenance of chromatin silencing relationship: part_of GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0035393 name: chemokine (C-X-C motif) ligand 9 production namespace: biological_process def: "The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add] synonym: "CXCL9 production" EXACT [] synonym: "MIG production" EXACT [] synonym: "Monokine induced by gamma interferon production" EXACT [] is_a: GO:0032602 ! chemokine production [Term] id: GO:0035394 name: regulation of chemokine (C-X-C motif) ligand 9 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf] synonym: "regulation of CXCL9 production" EXACT [] synonym: "regulation of MIG production" EXACT [] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production [Term] id: GO:0035395 name: negative regulation of chemokine (C-X-C motif) ligand 9 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf] synonym: "negative regulation of CXCL9 production" EXACT [] synonym: "negative regulation of MIG production" EXACT [] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production relationship: negatively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production [Term] id: GO:0035396 name: positive regulation of chemokine (C-X-C motif) ligand 9 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf] synonym: "positive regulation of CXCL9 production" EXACT [] synonym: "positive regulation of MIG production" EXACT [] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production relationship: positively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production [Term] id: GO:0035397 name: helper T cell enhancement of adaptive immune response namespace: biological_process def: "Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell." [GOC:add] synonym: "provision of T cell help" EXACT [] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0035398 name: helper T cell enhancement of T cell mediated immune response namespace: biological_process def: "Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add] synonym: "helper T cell enhancement of T cell mediated immunity" EXACT [] synonym: "provision of T cell help to T cell" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response [Term] id: GO:0035399 name: helper T cell enhancement of B cell mediated immune response namespace: biological_process def: "Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add] synonym: "helper T cell enhancement of B cell mediated immunity" EXACT [] synonym: "provision of T cell help to B cell" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response [Term] id: GO:0035400 name: histone tyrosine kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] synonym: "histone-tyrosine kinase activity" EXACT [] is_a: GO:0004713 ! protein tyrosine kinase activity is_a: GO:0035173 ! histone kinase activity [Term] id: GO:0035401 name: histone kinase activity (H3-Y41 specific) namespace: molecular_function def: "The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone." [GOC:bf] synonym: "histone tyrosine kinase activity (H3-Y41 specific)" EXACT [] synonym: "histone-tyrosine kinase activity (H3-Y41 specific)" EXACT [] is_a: GO:0035400 ! histone tyrosine kinase activity [Term] id: GO:0035402 name: histone kinase activity (H3-T11 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3." [GOC:bf] synonym: "histone threonine kinase activity (H3-T11 specific)" EXACT [] synonym: "histone-threonine kinase activity (H3-T11 specific)" EXACT [] is_a: GO:0035184 ! histone threonine kinase activity [Term] id: GO:0035403 name: histone kinase activity (H3-T6 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3." [GOC:bf] synonym: "histone threonine kinase activity (H3-T6 specific)" EXACT [] synonym: "histone-threonine kinase activity (H3-T6 specific)" EXACT [] is_a: GO:0035184 ! histone threonine kinase activity [Term] id: GO:0035404 name: histone-serine phosphorylation namespace: biological_process def: "The modification of histones by addition of a phosphate group to a serine residue." [GOC:bf] synonym: "histone serine phosphorylation" EXACT [] is_a: GO:0016572 ! histone phosphorylation is_a: GO:0018105 ! peptidyl-serine phosphorylation [Term] id: GO:0035405 name: histone-threonine phosphorylation namespace: biological_process def: "The modification of histones by addition of a phosphate group to a threonine residue." [GOC:bf] synonym: "histone threonine phosphorylation" EXACT [] is_a: GO:0016572 ! histone phosphorylation is_a: GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0035406 name: histone-tyrosine phosphorylation namespace: biological_process def: "The modification of histones by addition of a phosphate group to a tyrosine residue." [GOC:bf] synonym: "histone tyrosine phosphorylation" EXACT [] is_a: GO:0016572 ! histone phosphorylation is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation [Term] id: GO:0035407 name: histone H3-T11 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone." [GOC:bf] is_a: GO:0035405 ! histone-threonine phosphorylation [Term] id: GO:0035408 name: histone H3-T6 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone." [GOC:bf] is_a: GO:0035405 ! histone-threonine phosphorylation [Term] id: GO:0035409 name: histone H3-Y41 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone." [GOC:bf] is_a: GO:0035406 ! histone-tyrosine phosphorylation [Term] id: GO:0035410 name: dihydrotestosterone 17-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH." [GOC:ecd, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.1.1.63, PMID:4152755] xref: EC:1.1.1.- is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0035411 name: catenin import into nucleus namespace: biological_process def: "The directed movement of a catenin protein from the cytoplasm into the nucleus." [GOC:BHF] comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "catenin protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0035412 name: regulation of catenin import into nucleus namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus." [GOC:BHF] synonym: "regulation of catenin protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0042306 ! regulation of protein import into nucleus relationship: regulates GO:0035411 ! catenin import into nucleus [Term] id: GO:0035413 name: positive regulation of catenin import into nucleus namespace: biological_process def: "Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus." [GOC:BHF] synonym: "positive regulation of catenin protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0035412 ! regulation of catenin import into nucleus is_a: GO:0042307 ! positive regulation of protein import into nucleus relationship: positively_regulates GO:0035411 ! catenin import into nucleus [Term] id: GO:0035414 name: negative regulation of catenin import into nucleus namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus." [GOC:BHF] synonym: "negative regulation of catenin protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0035412 ! regulation of catenin import into nucleus is_a: GO:0042308 ! negative regulation of protein import into nucleus relationship: negatively_regulates GO:0035411 ! catenin import into nucleus [Term] id: GO:0035415 name: regulation of mitotic prometaphase namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf] is_a: GO:0007088 ! regulation of mitosis relationship: regulates GO:0000236 ! mitotic prometaphase [Term] id: GO:0035416 name: positive regulation of mitotic prometaphase namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf] is_a: GO:0035415 ! regulation of mitotic prometaphase is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0000236 ! mitotic prometaphase [Term] id: GO:0035417 name: negative regulation of mitotic prometaphase namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0035415 ! regulation of mitotic prometaphase relationship: negatively_regulates GO:0000236 ! mitotic prometaphase [Term] id: GO:0035418 name: protein localization to synapse namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf] synonym: "protein localisation to synapse" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization [Term] id: GO:0035419 name: activation of MAPK activity involved in innate immune response namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] xref: Reactome:433822 "NFkB and MAPK activation mediated by TRAF6" xref: Reactome:573298 "NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation" is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0002758 ! innate immune response-activating signal transduction relationship: part_of GO:0035420 ! MAPKKK cascade involved in innate immune response [Term] id: GO:0035420 name: MAPKKK cascade involved in innate immune response namespace: biological_process def: "A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] is_a: GO:0000165 ! MAPKKK cascade relationship: part_of GO:0045087 ! innate immune response [Term] id: GO:0035421 name: activation of MAPKK activity involved in innate immune response namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] is_a: GO:0000186 ! activation of MAPKK activity is_a: GO:0002758 ! innate immune response-activating signal transduction relationship: part_of GO:0035420 ! MAPKKK cascade involved in innate immune response [Term] id: GO:0035422 name: activation of MAPKKK activity involved in innate immune response namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] is_a: GO:0000185 ! activation of MAPKKK activity is_a: GO:0002758 ! innate immune response-activating signal transduction relationship: part_of GO:0035420 ! MAPKKK cascade involved in innate immune response [Term] id: GO:0035423 name: inactivation of MAPK activity involved in innate immune response namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] is_a: GO:0000188 ! inactivation of MAPK activity is_a: GO:0002766 ! innate immune response-inhibiting signal transduction relationship: part_of GO:0035420 ! MAPKKK cascade involved in innate immune response [Term] id: GO:0035424 name: MAPK import into nucleus involved in innate immune response namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] synonym: "nuclear translocation of MAPK involved in innate immune response" NARROW [GOC:mah] is_a: GO:0000189 ! MAPK import into nucleus is_a: GO:0002758 ! innate immune response-activating signal transduction relationship: part_of GO:0035420 ! MAPKKK cascade involved in innate immune response [Term] id: GO:0035425 name: autocrine signaling namespace: biological_process def: "Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type." [GOC:bf, ISBN:3527303782 "Biochemisty of Signal Transduction and Regulation"] synonym: "autocrine signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0035426 name: extracellular matrix-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information between the extracellular matrix and a cell." [GOC:bf] synonym: "cell-extracellular matrix signalling" EXACT [] synonym: "extracellular matrix-cell signaling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0035427 name: purine nucleoside transmembrane transport namespace: biological_process def: "The directed movement of a purine nucleoside across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0015860 ! purine nucleoside transport [Term] id: GO:0035428 name: hexose transmembrane transport namespace: biological_process def: "The directed movement of hexose across a membrane by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:vw] is_a: GO:0008645 ! hexose transport is_a: GO:0034219 ! carbohydrate transmembrane transport [Term] id: GO:0035429 name: gluconate transmembrane transport namespace: biological_process def: "The directed movement of gluconate across a membrane by means of some agent such as a transporter or pore. Gluconate is the aldonic acid derived from glucose." [GOC:vw, ISBN:0198506732] is_a: GO:0015725 ! gluconate transport is_a: GO:0035428 ! hexose transmembrane transport [Term] id: GO:0035430 name: regulation of gluconate transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0032893 ! regulation of gluconate transport is_a: GO:0034762 ! regulation of transmembrane transport relationship: regulates GO:0035429 ! gluconate transmembrane transport [Term] id: GO:0035431 name: negative regulation of gluconate transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0032894 ! negative regulation of gluconate transport is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0035430 ! regulation of gluconate transmembrane transport relationship: negatively_regulates GO:0035429 ! gluconate transmembrane transport [Term] id: GO:0035432 name: positive regulation of gluconate transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0032895 ! positive regulation of gluconate transport is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0035430 ! regulation of gluconate transmembrane transport relationship: positively_regulates GO:0035429 ! gluconate transmembrane transport [Term] id: GO:0035433 name: acetate transmembrane transport namespace: biological_process def: "The directed movement of acetate across a membrane by means of some agent such as a transporter or pore. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:vw] is_a: GO:0006846 ! acetate transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0035434 name: copper ion transmembrane transport namespace: biological_process def: "The directed movement of copper (Cu) ions across a membrane by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0006825 ! copper ion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0035435 name: phosphate transmembrane transport namespace: biological_process def: "The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0006817 ! phosphate transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0035436 name: triose phosphate transmembrane transport namespace: biological_process def: "The directed movement of triose phosphate across a membrane by means of some agent such as a transporter or pore. Triose phosphate is any organic three carbon compound phosphate ester." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015717 ! triose phosphate transport is_a: GO:0034219 ! carbohydrate transmembrane transport [Term] id: GO:0035437 name: maintenance of protein localization in endoplasmic reticulum namespace: biological_process def: "Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum." [GOC:bf, GOC:vw] synonym: "maintenance of protein localisation in endoplasmic reticulum" EXACT [GOC:mah] synonym: "maintenance of protein localization in ER" EXACT [] synonym: "maintenance of protein location in endoplasmic reticulum" EXACT [] synonym: "maintenance of protein location in ER" EXACT [] synonym: "protein-endoplasmic reticulum retention" EXACT [] synonym: "protein-ER retention" EXACT [] synonym: "retention of protein in endoplasmic reticulum" EXACT [] synonym: "retention of protein in ER" EXACT [] is_a: GO:0072595 ! maintenance of protein localization to organelle relationship: part_of GO:0070972 ! protein localization in endoplasmic reticulum [Term] id: GO:0035438 name: cyclic-di-GMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate." [CHEBI:49537, GOC:bf] synonym: "3',5'-cyclic di-GMP binding" EXACT [CHEBI:49537] synonym: "c-di-GMP binding" EXACT [CHEBI:49537] synonym: "cyclic dinucleotide di-GMP binding" EXACT [CHEBI:49537] is_a: GO:0030551 ! cyclic nucleotide binding is_a: GO:0032561 ! guanyl ribonucleotide binding [Term] id: GO:0035439 name: halimadienyl-diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate." [EC:5.5.1.16] synonym: "halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)" EXACT [EC:5.5.1.16] synonym: "halimadienyl diphosphate synthase activity" EXACT [EC:5.5.1.16] xref: EC:5.5.1.16 is_a: GO:0009975 ! cyclase activity is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0035440 name: tuberculosinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tuberculosinol (halima-5,6,dien-15-ol), a secondary metabolite in Mycobacteria." [CHEBI:50387, MetaCyc:PWY-5935] synonym: "halima-5,6,dien-15-ol biosynthesis" EXACT [CHEBI:50387] synonym: "halima-5,6,dien-15-ol biosynthetic process" EXACT [CHEBI:50387] synonym: "tuberculosinol biosynthesis" EXACT [] xref: MetaCyc:PWY-5935 is_a: GO:0016102 ! diterpenoid biosynthetic process [Term] id: GO:0035441 name: cell migration involved in vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh] is_a: GO:0016477 ! cell migration relationship: part_of GO:0001570 ! vasculogenesis [Term] id: GO:0035442 name: dipeptide transmembrane transport namespace: biological_process def: "The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:vw] is_a: GO:0035672 ! oligopeptide transmembrane transport is_a: GO:0042938 ! dipeptide transport [Term] id: GO:0035443 name: tripeptide transmembrane transport namespace: biological_process def: "The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds." [GOC:vw] is_a: GO:0035672 ! oligopeptide transmembrane transport is_a: GO:0042939 ! tripeptide transport [Term] id: GO:0035444 name: nickel ion transmembrane transport namespace: biological_process def: "The directed movement of nickel (Ni) ions across a membrane by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0015675 ! nickel ion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0035445 name: borate transmembrane transport namespace: biological_process def: "The directed movement of borate across a membrane by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [CHEBI:22908, GOC:curators] synonym: "boron transmembrane transport" RELATED [GOC:curators] is_a: GO:0034220 ! ion transmembrane transport is_a: GO:0046713 ! borate transport [Term] id: GO:0035446 name: cysteine-glucosaminylinositol ligase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins." [EC:6.3.1.13, MetaCyc:CPLX-5721, PMID:12033919] synonym: "desacetylmycothiol synthase" RELATED [PMID:12033919] synonym: "L-cysteine : 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase" EXACT [EC:6.3.1.13] synonym: "MshC ligase" EXACT [EC:6.3.1.13] xref: EC:6.3.1.13 xref: MetaCyc:RXN1G-4 xref: Reactome:870314 "cysteine-glucosaminylinositol ligase activity" is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0035447 name: mycothiol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol." [MetaCyc:MONOMER-9684, PMID:12033919] synonym: "acetyl-CoA:Cys-GlcN-Ins acetyltransferase" EXACT [] xref: MetaCyc:MONOMER-9684 xref: Reactome:870388 "mycothiol synthase activity" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0035448 name: extrinsic to thylakoid membrane namespace: cellular_component def: "Loosely bound to one surface of a thylakoid membrane, but not integrated into the hydrophobic region." [GOC:bf] synonym: "peripheral to thylakoid membrane" EXACT [] is_a: GO:0019898 ! extrinsic to membrane is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0035449 name: extrinsic to plastid thylakoid membrane namespace: cellular_component def: "Loosely bound to one surface of a plastid thylakoid membrane, but not integrated into the hydrophobic region." [GOC:bf] synonym: "peripheral to plastid thylakoid membrane" EXACT [] is_a: GO:0035448 ! extrinsic to thylakoid membrane is_a: GO:0044435 ! plastid part relationship: part_of GO:0055035 ! plastid thylakoid membrane [Term] id: GO:0035450 name: extrinsic to lumenal side of plastid thylakoid membrane namespace: cellular_component def: "Loosely bound to the surface of a plastid thylakoid membrane that faces the lumen but not integrated into the hydrophobic region." [GOC:bf] synonym: "peripheral to lumenal side of plastid thylakoid membrane" EXACT [] is_a: GO:0035449 ! extrinsic to plastid thylakoid membrane [Term] id: GO:0035451 name: extrinsic to stromal side of plastid thylakoid membrane namespace: cellular_component def: "Loosely bound to the surface of a plastid thylakoid membrane that faces the stroma but not integrated into the hydrophobic region." [GOC:bf] synonym: "peripheral to stromal side of plastid thylakoid membrane" EXACT [] is_a: GO:0035449 ! extrinsic to plastid thylakoid membrane [Term] id: GO:0035452 name: extrinsic to plastid membrane namespace: cellular_component def: "Loosely bound to one surface of a plastid membrane, but not integrated into the hydrophobic region." [GOC:bf] synonym: "peripheral to plastid membrane" EXACT [] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044435 ! plastid part relationship: part_of GO:0042170 ! plastid membrane [Term] id: GO:0035453 name: extrinsic to plastid inner membrane namespace: cellular_component def: "Loosely bound to one surface of a plastid inner membrane, but not integrated into the hydrophobic region." [GOC:bf] synonym: "peripheral to plastid inner membrane" EXACT [] is_a: GO:0035452 ! extrinsic to plastid membrane relationship: part_of GO:0009528 ! plastid inner membrane [Term] id: GO:0035454 name: extrinsic to stromal side of plastid inner membrane namespace: cellular_component def: "Loosely bound to the surface of a plastid inner membrane that faces the stroma, but not integrated into the hydrophobic region." [GOC:bf] synonym: "peripheral to stromal side of plastid inner membrane" EXACT [] is_a: GO:0035453 ! extrinsic to plastid inner membrane [Term] id: GO:0035455 name: response to interferon-alpha namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl, PMID:11356686] synonym: "response to interferon alfa-n1" RELATED [GOC:sl] synonym: "response to interferon alfa-n3" RELATED [GOC:sl] synonym: "response to leukocyte interferon" EXACT [GOC:sl] synonym: "response to lymphoblast interferon" EXACT [GOC:sl] synonym: "response to lymphoblastoid interferon" EXACT [GOC:sl] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0035456 name: response to interferon-beta namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374] synonym: "response to beta-1 interferon" RELATED [GOC:sl] synonym: "response to fiblaferon" EXACT [GOC:sl] synonym: "response to fibroblast interferon" EXACT [GOC:sl] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0035457 name: cellular response to interferon-alpha namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl] synonym: "cellular response to interferon alfa-n1" RELATED [GOC:sl] synonym: "cellular response to interferon alfa-n3" RELATED [GOC:sl] synonym: "cellular response to leukocyte interferon" EXACT [GOC:sl] synonym: "cellular response to lymphoblast interferon" EXACT [GOC:sl] synonym: "cellular response to lymphoblastoid interferon" EXACT [GOC:sl] is_a: GO:0035455 ! response to interferon-alpha is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0035458 name: cellular response to interferon-beta namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl] synonym: "cellular response to beta-1 interferon" RELATED [GOC:sl] synonym: "cellular response to fiblaferon" EXACT [GOC:sl] synonym: "cellular response to fibroblast interferon" EXACT [GOC:sl] is_a: GO:0035456 ! response to interferon-beta is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0035459 name: cargo loading into vesicle namespace: biological_process def: "The formation of a protein complex between the coat proteins and proteins that are going to be transported by a vesicle." [GOC:bf] synonym: "cargo selection" EXACT [GOC:vw] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0035460 name: L-ascorbate 6-phosphate lactonase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate." [PMID:18097099, PMID:20359483] xref: EC:3.1.1.- is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0035461 name: vitamin transmembrane transport namespace: biological_process def: "The process in which a vitamin is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:bf] is_a: GO:0051180 ! vitamin transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035462 name: determination of left/right asymmetry in diencephalon namespace: biological_process def: "The establishment of the diencephalon with respect to the left and right halves." [GOC:dgh, PMID:15084459] is_a: GO:0035545 ! determination of left/right asymmetry in nervous system relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0035463 name: transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to determination of organismal asymmetry with respect to the left and right halves." [GOC:dgh] synonym: "TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: part_of GO:0007368 ! determination of left/right symmetry [Term] id: GO:0035464 name: regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of organismal asymmetry with regard to its left and right halves." [GOC:dgh] synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry [Term] id: GO:0035465 name: regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of the lateral plate mesoderm with respect to its left and right halves." [GOC:dgh, PMID:15084459] synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] is_a: GO:0035464 ! regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry is_a: GO:2000380 ! regulation of mesoderm development relationship: regulates GO:0003141 ! transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry [Term] id: GO:0035469 name: determination of pancreatic left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism." [GOC:dgh, PMID:12702646] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0031016 ! pancreas development [Term] id: GO:0035470 name: positive regulation of vascular wound healing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:rph] is_a: GO:0045766 ! positive regulation of angiogenesis is_a: GO:0061043 ! regulation of vascular wound healing is_a: GO:0090303 ! positive regulation of wound healing relationship: positively_regulates GO:0061042 ! vascular wound healing [Term] id: GO:0035471 name: luteinizing hormone signaling pathway involved in ovarian follicle development namespace: biological_process def: "The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:bf] synonym: "luteinizing hormone signalling pathway involved in ovarian follicle development" EXACT [GOC:mah] is_a: GO:0042700 ! luteinizing hormone signaling pathway is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0035472 name: choriogonadotropin hormone receptor activity namespace: molecular_function def: "Combining with the choriogonadotropin hormone to initiate a change in cell activity." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:1922095] synonym: "CG receptor activity" EXACT [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "chorio-gonadotrophin receptor activity" EXACT [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "chorionic gonadotropin hormone receptor" EXACT [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0035473 name: lipase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any lipase." [GOC:BHF] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0035474 name: selective angioblast sprouting namespace: biological_process def: "The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel." [GOC:dgh, PMID:19815777] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0035475 name: angioblast cell migration involved in selective angioblast sprouting namespace: biological_process def: "The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations." [GOC:dgh, PMID:19815777] is_a: GO:0035476 ! angioblast cell migration relationship: part_of GO:0035474 ! selective angioblast sprouting [Term] id: GO:0035476 name: angioblast cell migration namespace: biological_process def: "The orderly movement of angioblasts, cells involved in blood vessel morphogenesis." [GOC:dgh, PMID:19815777] is_a: GO:0016477 ! cell migration relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0035477 name: regulation of angioblast cell migration involved in selective angioblast sprouting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting." [GOC:dgh, PMID:19815777] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0035475 ! angioblast cell migration involved in selective angioblast sprouting [Term] id: GO:0035478 name: chylomicron binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE." [GOC:BHF, http://www.britannica.com/EBchecked/topic/117461/chylomicron] is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0035479 name: angioblast cell migration from lateral mesoderm to midline namespace: biological_process def: "The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature." [GOC:dgh, PMID:11861480] is_a: GO:0035476 ! angioblast cell migration [Term] id: GO:0035480 name: regulation of Notch signaling pathway involved in heart induction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF] synonym: "regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0008593 ! regulation of Notch signaling pathway is_a: GO:0090381 ! regulation of heart induction is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0003137 ! Notch signaling pathway involved in heart induction [Term] id: GO:0035481 name: positive regulation of Notch signaling pathway involved in heart induction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF] synonym: "positive regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0035480 ! regulation of Notch signaling pathway involved in heart induction is_a: GO:0045747 ! positive regulation of Notch signaling pathway relationship: positively_regulates GO:0003137 ! Notch signaling pathway involved in heart induction [Term] id: GO:0035482 name: gastric motility namespace: biological_process def: "The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum." [GOC:cy, ISBN:9781416032458, PMID:16139031] is_a: GO:0022600 ! digestive system process [Term] id: GO:0035483 name: gastric emptying namespace: biological_process def: "The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:cy, ISBN:9781416032458] is_a: GO:0035482 ! gastric motility [Term] id: GO:0035484 name: adenine/adenine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/A mispair." [GOC:bf, GOC:jh] synonym: "A/A mispair binding" EXACT [GOC:jh] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0035485 name: adenine/guanine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/G mispair." [GOC:bf, GOC:jh] synonym: "A/G mispair binding" EXACT [GOC:jh] synonym: "G/A mispair binding" RELATED [GOC:bf] synonym: "guanine-adenine mispair binding" EXACT [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0035486 name: cytosine/cytosine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a C/C mispair." [GOC:bf, GOC:jh] synonym: "C/C mispair binding" EXACT [GOC:jh] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0035487 name: thymine/thymine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a T/T mispair." [GOC:bf, GOC:jh] synonym: "T/T mispair binding" EXACT [] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0035488 name: cytosine/thymine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a C/T mispair." [GOC:bf, GOC:jh] synonym: "C/T mispair binding" EXACT [GOC:jh] synonym: "T/C mispair binding" EXACT [GOC:bf] synonym: "thymine/cytosine mispair binding" EXACT [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0035489 name: guanine/guanine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a G/G mispair." [GOC:bf, GOC:jh] synonym: "G/G mispair binding" EXACT [GOC:jh] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0035490 name: regulation of leukotriene production involved in inflammatory response namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0002540 ! leukotriene production involved in inflammatory response [Term] id: GO:0035491 name: positive regulation of leukotriene production involved in inflammatory response namespace: biological_process def: "Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0002540 ! leukotriene production involved in inflammatory response [Term] id: GO:0035492 name: negative regulation of leukotriene production involved in inflammatory response namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0002540 ! leukotriene production involved in inflammatory response [Term] id: GO:0035493 name: SNARE complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006906 ! vesicle fusion [Term] id: GO:0035494 name: SNARE complex disassembly namespace: biological_process def: "The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:11697877] is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0035495 name: regulation of SNARE complex disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0043244 ! regulation of protein complex disassembly is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0035494 ! SNARE complex disassembly [Term] id: GO:0035496 name: lipopolysaccharide-1,5-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.-, PMID:11304545] synonym: "LPS-1,5-galactosyltransferase activity" EXACT [PMID:11304545] synonym: "UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase" EXACT [PMID:11304545] xref: EC:2.4.1.- is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0035497 name: cAMP response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "cAMP-responsive element binding" EXACT [PMID:2875459] synonym: "CRE binding" EXACT [PMID:2900470] synonym: "cyclic AMP response element binding" EXACT [PMID:2900470] synonym: "cyclic-AMP response element binding" EXACT [PMID:2900470] synonym: "cyclic-AMP-responsive element binding" EXACT [PMID:2875459] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0035498 name: carnosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine)." [PMID:20097752] synonym: "carnosine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0035499 name: carnosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine)." [EC:6.3.2.11, PMID:20097752] synonym: "carnosine anabolism" EXACT [] synonym: "carnosine biosynthesis" EXACT [] synonym: "carnosine formation" EXACT [] synonym: "carnosine synthesis" EXACT [] is_a: GO:0035498 ! carnosine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0035500 name: MH2 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers." [Pfam:PF03166] synonym: "MAD homology 2 domain binding" EXACT [Pfam:PF03166] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0035501 name: MH1 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the MH1 (MAD homology 1) domain of a protein. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors." [Pfam:PF03165] synonym: "MAD homology 1 domain binding" EXACT [Pfam:PF03165] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0035502 name: metanephric ureteric bud development namespace: biological_process def: "The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0001657 ! ureteric bud development relationship: part_of GO:0003338 ! metanephros morphogenesis [Term] id: GO:0035503 name: ureter ureteric bud development namespace: biological_process def: "The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0001657 ! ureteric bud development relationship: part_of GO:0072197 ! ureter morphogenesis [Term] id: GO:0035504 name: regulation of myosin light chain kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity [Term] id: GO:0035505 name: positive regulation of myosin light chain kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators] is_a: GO:0035504 ! regulation of myosin light chain kinase activity is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity [Term] id: GO:0035506 name: negative regulation of myosin light chain kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators] is_a: GO:0035504 ! regulation of myosin light chain kinase activity is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity [Term] id: GO:0035507 name: regulation of myosin-light-chain-phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators] is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity [Term] id: GO:0035508 name: positive regulation of myosin-light-chain-phosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators] is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity is_a: GO:0035507 ! regulation of myosin-light-chain-phosphatase activity [Term] id: GO:0035509 name: negative regulation of myosin-light-chain-phosphatase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators] is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity is_a: GO:0035507 ! regulation of myosin-light-chain-phosphatase activity [Term] id: GO:0035510 name: DNA dealkylation namespace: biological_process def: "The removal of an alkyl group from one or more nucleotides within an DNA molecule." [GOC:bf] is_a: GO:0006304 ! DNA modification [Term] id: GO:0035511 name: oxidative DNA demethylation namespace: biological_process def: "Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] is_a: GO:0070989 ! oxidative demethylation is_a: GO:0080111 ! DNA demethylation [Term] id: GO:0035512 name: hydrolytic DNA demethylation namespace: biological_process def: "The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule." [GOC:bf] is_a: GO:0080111 ! DNA demethylation [Term] id: GO:0035513 name: oxidative RNA demethylation namespace: biological_process def: "The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] is_a: GO:0009451 ! RNA modification is_a: GO:0070989 ! oxidative demethylation [Term] id: GO:0035514 name: DNA demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule." [GOC:bf] is_a: GO:0032451 ! demethylase activity [Term] id: GO:0035515 name: oxidative RNA demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] synonym: "2-oxoglutarate-dependent RNA demethylase" EXACT [PMID:17991826] is_a: GO:0016491 ! oxidoreductase activity is_a: GO:0032451 ! demethylase activity [Term] id: GO:0035516 name: oxidative DNA demethylase activity namespace: molecular_function def: "Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] synonym: "2-oxoglutarate-dependent DNA demethylase" EXACT [PMID:17991826] is_a: GO:0016491 ! oxidoreductase activity is_a: GO:0035514 ! DNA demethylase activity [Term] id: GO:0035517 name: PR-DUB complex namespace: cellular_component def: "A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively." [PMID:20436459] synonym: "Polycomb repressive deubiquitinase complex" EXACT [PMID:20436459] is_a: GO:0031519 ! PcG protein complex [Term] id: GO:0035518 name: histone H2A monoubiquitination namespace: biological_process def: "The modification of histone H2A by addition of a single ubiquitin group. Steady-state modification of histone H2A occurs at lysine 119 (H2A-K119) in metazoans, and at the equivalent residue in other organisms." [PMID:18206970] is_a: GO:0010390 ! histone monoubiquitination is_a: GO:0033522 ! histone H2A ubiquitination [Term] id: GO:0035519 name: protein K29-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation." [PMID:17028573] synonym: "protein K29-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination [Term] id: GO:0035520 name: monoubiquitinated protein deubiquitination namespace: biological_process def: "The removal of the ubiquitin group from a monoubiquitinated protein." [GOC:bf] synonym: "monoubiquitinated protein deubiquitinylation" EXACT [] synonym: "monoubiquitinated protein deubiquitylation" EXACT [] is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0035521 name: monoubiquitinated histone deubiquitination namespace: biological_process def: "The removal of the ubiquitin group from a monoubiquitinated histone protein." [GOC:bf, PMID:20436459] synonym: "monoubiquitinated histone deubiquitinylation" EXACT [] synonym: "monoubiquitinated histone deubiquitylation" EXACT [] is_a: GO:0016578 ! histone deubiquitination is_a: GO:0035520 ! monoubiquitinated protein deubiquitination [Term] id: GO:0035522 name: monoubiquitinated histone H2A deubiquitination namespace: biological_process def: "The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459] synonym: "monoubiquitinated histone H2A deubiquitinylation" EXACT [] synonym: "monoubiquitinated histone H2A deubiquitylation" EXACT [] is_a: GO:0035521 ! monoubiquitinated histone deubiquitination [Term] id: GO:0035523 name: protein K29-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein." [GOC:bf] synonym: "protein K29-linked deubiquitinylation" EXACT [] synonym: "protein K29-linked deubiquitylation" EXACT [] is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0035524 name: proline transmembrane transport namespace: biological_process def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015824 ! proline transport [Term] id: GO:0035525 name: NF-kappaB p50/p65 complex namespace: cellular_component def: "A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584] comment: Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications. synonym: "NF-kappa B1/p65 complex" EXACT [PMID:9299584] synonym: "NF-kappa B1/RelA complex" EXACT [PMID:9299584] synonym: "NF-kappa p105/p65 complex" RELATED [PMID:9299584] synonym: "NF-kappa p105/RelA complex" RELATED [PMID:9299584] synonym: "NF-kappa p50/RelA complex" EXACT [PMID:9299584] is_a: GO:0071159 ! NF-kappaB complex [Term] id: GO:0035526 name: retrograde transport, plasma membrane to Golgi namespace: biological_process def: "The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles." [GOC:lb, PMID:17488291] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0035527 name: 3-hydroxypropionate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropionate + NADP+ = malonate semialdehyde + NADPH + H+." [EC:1.1.1.298] synonym: "3-hydroxypropionate:NADP+ oxidoreductase" EXACT [EC:1.1.1.298] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0035528 name: UDP-N-acetylglucosamine biosynthesis involved in chitin biosynthesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine in glycosidic linkage with uridine diphosphate, that contribute to the biosynthesis of chitin." [GOC:bf] synonym: "UDP-GlcNAc biosynthesis involved in chitin biosynthesis" EXACT [] synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthesis" EXACT [] synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthetic process" EXACT [] synonym: "UDP-N-acetylglucosamine anabolism involved in chitin biosynthesis" EXACT [] synonym: "UDP-N-acetylglucosamine biosynthetic process involved in chitin biosynthetic process" EXACT [] synonym: "UDP-N-acetylglucosamine formation involved in chitin biosynthesis" EXACT [] synonym: "UDP-N-acetylglucosamine synthesis involved in chitin biosynthesis" EXACT [] is_a: GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process relationship: part_of GO:0006031 ! chitin biosynthetic process [Term] id: GO:0035529 name: NADH pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+." [MetaCyc:RXN0-4401, PMID:12399474, PMID:20181750] synonym: "NADH diphosphatase activity" EXACT [] synonym: "NADH pyrophosphohydrolase activity" EXACT [] is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0035530 name: chemokine (C-C motif) ligand 6 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, PMID:19812544] synonym: "CCL6 production" EXACT [] is_a: GO:0032602 ! chemokine production [Term] id: GO:0035531 name: regulation of chemokine (C-C motif) ligand 6 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] synonym: "regulation of CCL6 production" EXACT [] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production [Term] id: GO:0035532 name: negative regulation of chemokine (C-C motif) ligand 6 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] synonym: "negative regulation of CCL6 production" EXACT [] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production relationship: negatively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production [Term] id: GO:0035533 name: positive regulation of chemokine (C-C motif) ligand 6 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] synonym: "positive regulation of CCL6 production" EXACT [] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production relationship: positively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production [Term] id: GO:0035534 name: chemokine (C-C motif) ligand 6 secretion namespace: biological_process def: "The regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell or group of cells." [GOC:add, GOC:amm] synonym: "CCL6 secretion" EXACT [] is_a: GO:0090195 ! chemokine secretion relationship: part_of GO:0035530 ! chemokine (C-C motif) ligand 6 production [Term] id: GO:0035535 name: regulation of chemokine (C-C motif) ligand 6 secretion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell or group of cells." [GOC:add, GOC:bf] synonym: "regulation of CCL6 secretion" EXACT [] is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production is_a: GO:0090196 ! regulation of chemokine secretion relationship: regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion [Term] id: GO:0035536 name: negative regulation of chemokine (C-C motif) ligand 6 secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell or group of cells." [GOC:add, GOC:bf] synonym: "negative regulation of CCL6 secretion" EXACT [] is_a: GO:0035532 ! negative regulation of chemokine (C-C motif) ligand 6 production is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion is_a: GO:0090198 ! negative regulation of chemokine secretion relationship: negatively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion [Term] id: GO:0035537 name: positive regulation of chemokine (C-C motif) ligand 6 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell or group of cells." [GOC:add, GOC:bf] synonym: "positive regulation of CCL6 secretion" EXACT [] is_a: GO:0035533 ! positive regulation of chemokine (C-C motif) ligand 6 production is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion is_a: GO:0090197 ! positive regulation of chemokine secretion relationship: positively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion [Term] id: GO:0035538 name: carbohydrate response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes." [GOC:BHF, PMID:20001964] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "ChoRE binding" EXACT [PMID:20001964] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0035539 name: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA." [PMID:17804481, PMID:7782328, PMID:7859359] synonym: "8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity" EXACT [PMID:17804481] synonym: "8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity" EXACT [PMID:17804481] synonym: "8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity" EXACT [PMID:7782328] synonym: "8-oxo-dGTP pyrophosphohydrolase activity" EXACT [PMID:17804481] synonym: "8-oxo-dGTPase activity" EXACT [PMID:7782328] is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0035540 name: positive regulation of SNARE complex disassembly namespace: biological_process def: "Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0035495 ! regulation of SNARE complex disassembly is_a: GO:0043243 ! positive regulation of protein complex disassembly is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0035494 ! SNARE complex disassembly [Term] id: GO:0035541 name: negative regulation of SNARE complex disassembly namespace: biological_process def: "Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0035495 ! regulation of SNARE complex disassembly is_a: GO:0043242 ! negative regulation of protein complex disassembly is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0035494 ! SNARE complex disassembly [Term] id: GO:0035542 name: regulation of SNARE complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0043254 ! regulation of protein complex assembly relationship: regulates GO:0035493 ! SNARE complex assembly [Term] id: GO:0035543 name: positive regulation of SNARE complex assembly namespace: biological_process def: "Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0035542 ! regulation of SNARE complex assembly relationship: positively_regulates GO:0035493 ! SNARE complex assembly [Term] id: GO:0035544 name: negative regulation of SNARE complex assembly namespace: biological_process def: "Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0035542 ! regulation of SNARE complex assembly relationship: negatively_regulates GO:0035493 ! SNARE complex assembly [Term] id: GO:0035545 name: determination of left/right asymmetry in nervous system namespace: biological_process def: "The establishment of the nervous system with respect to the left and right halves." [GOC:kmv, PMID:17717195, PMID:19641012] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0035546 name: interferon-beta secretion namespace: biological_process def: "The regulated release of interferon-beta from a cell or group of cells." [GOC:add, GOC:bf] synonym: "IFN-beta secretion" EXACT [] synonym: "IFNB secretion" EXACT [GOC:mah] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0032608 ! interferon-beta production [Term] id: GO:0035547 name: regulation of interferon-beta secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf] synonym: "regulation of IFN-beta secretion" EXACT [] is_a: GO:0032648 ! regulation of interferon-beta production is_a: GO:0050707 ! regulation of cytokine secretion relationship: regulates GO:0035546 ! interferon-beta secretion [Term] id: GO:0035548 name: negative regulation of interferon-beta secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf] synonym: "down regulation of interferon-beta secretion" EXACT [] synonym: "down-regulation of interferon-beta secretion" EXACT [] synonym: "downregulation of interferon-beta secretion" EXACT [] synonym: "inhibition of interferon-beta secretion" NARROW [] synonym: "negative regulation of IFN-beta secretion" EXACT [] is_a: GO:0032688 ! negative regulation of interferon-beta production is_a: GO:0035547 ! regulation of interferon-beta secretion is_a: GO:0050710 ! negative regulation of cytokine secretion relationship: negatively_regulates GO:0035546 ! interferon-beta secretion [Term] id: GO:0035549 name: positive regulation of interferon-beta secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf] synonym: "activation of interferon-beta secretion" NARROW [] synonym: "positive regulation of IFN-beta secretion" EXACT [] synonym: "stimulation of interferon-beta secretion" NARROW [] synonym: "up regulation of interferon-beta secretion" EXACT [] synonym: "up-regulation of interferon-beta secretion" EXACT [] synonym: "upregulation of interferon-beta secretion" EXACT [] is_a: GO:0032728 ! positive regulation of interferon-beta production is_a: GO:0035547 ! regulation of interferon-beta secretion is_a: GO:0050715 ! positive regulation of cytokine secretion relationship: positively_regulates GO:0035546 ! interferon-beta secretion [Term] id: GO:0035550 name: urease complex namespace: cellular_component def: "A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide)." [InterPro:IPR008221, PMID:2651866] comment: Eukaryotic microorganisms, plants, and probably Gram-positive bacteria, possess a homopolymeric urease. In contrast, urease complexes from gram-negative bacteria studied thus far clearly possess three distinct subunits (alpha, beta and gamma). Tightly bound nickel is present in all urease complexes. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0035551 name: protein initiator methionine removal involved in protein maturation namespace: biological_process def: "Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein." [GOC:bf, GOC:hjd, GOC:vw] is_a: GO:0051605 ! protein maturation by peptide bond cleavage is_a: GO:0070084 ! protein initiator methionine removal [Term] id: GO:0035552 name: oxidative single-stranded DNA demethylation namespace: biological_process def: "Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:rl, PMID:18775698] synonym: "oxidative ssDNA demethylation" EXACT [] is_a: GO:0035511 ! oxidative DNA demethylation [Term] id: GO:0035553 name: oxidative single-stranded RNA demethylation namespace: biological_process def: "Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:rl, PMID:18775698] synonym: "oxidative ssRNA demethylation" EXACT [] is_a: GO:0035513 ! oxidative RNA demethylation [Term] id: GO:0035554 name: termination of Roundabout signal transduction namespace: biological_process def: "The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated." [GOC:vk] is_a: GO:0023021 ! termination of signal transduction is_a: GO:0035387 ! negative regulation of Roundabout signaling pathway relationship: part_of GO:0035385 ! Roundabout signaling pathway [Term] id: GO:0035555 name: initiation of Roundabout signal transduction namespace: biological_process def: "OBSOLETE. The process in which a SLIT protein causes activation of the receptor, Roundabout (ROBO)." [GOC:vk] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0004872 consider: GO:0035385 consider: GO:0048018 consider: GO:0048495 [Term] id: GO:0035556 name: intracellular signal transduction namespace: biological_process alt_id: GO:0007242 alt_id: GO:0023013 alt_id: GO:0023034 def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782 "Biochemistry of Signal Transduction and Regulation"] synonym: "intracellular signal transduction pathway" NARROW [] synonym: "intracellular signaling cascade" EXACT [] synonym: "intracellular signaling chain" EXACT [ISBN:3527303782 "Biochemistry of Signal Transduction and Regulation"] synonym: "intracellular signaling pathway" RELATED [] synonym: "signal transduction via intracellular signaling cascade" RELATED [] synonym: "signal transmission via intracellular cascade" NARROW [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0035557 name: intracellular signal transduction involved in cell surface receptor linked signaling namespace: biological_process def: "The process in which a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782 "Biochemistry of Signal Transduction and Regulation"] synonym: "intracellular signal transduction involved in cell surface receptor linked signalling" EXACT [GOC:mah] synonym: "intracellular signaling cascade involved in cell surface receptor linked signaling" EXACT [] synonym: "intracellular signaling chain involved in cell surface receptor signaling" EXACT [ISBN:3527303782 "Biochemistry of Signal Transduction and Regulation"] is_a: GO:0035556 ! intracellular signal transduction relationship: part_of GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0035558 name: phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling namespace: biological_process def: "The process in which a signal is passed from the insulin receptor to components of the phosphatidylinositol 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:signaling] synonym: "phosphatidylinositol 3-kinase cascade involved in insulin receptor signalling" EXACT [GOC:curators] synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signaling" EXACT [GOC:curators] synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signalling" EXACT [GOC:mah] synonym: "PI3K cascade involved in signaling from the insulin receptor" EXACT [] is_a: GO:0014065 ! phosphatidylinositol 3-kinase cascade is_a: GO:0035557 ! intracellular signal transduction involved in cell surface receptor linked signaling relationship: part_of GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0035559 name: MAPKKK cascade involved in epidermal growth factor receptor signaling namespace: biological_process def: "The process in which a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling] synonym: "MAPKKK cascade involved in epidermal growth factor receptor signalling" EXACT [GOC:mah] synonym: "MAPKKK cascade involved in signaling from the EGFR" EXACT [] is_a: GO:0000165 ! MAPKKK cascade is_a: GO:0035557 ! intracellular signal transduction involved in cell surface receptor linked signaling relationship: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0035560 name: pheophoridase activity namespace: molecular_function def: "Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a." [EC:3.1.1.82, PMID:16228561] synonym: "phedase activity" EXACT [EC:3.1.1.82] synonym: "PPD activity" EXACT [EC:3.1.1.82] xref: EC:3.1.1.82 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0035561 name: regulation of chromatin binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf] is_a: GO:0051098 ! regulation of binding [Term] id: GO:0035562 name: negative regulation of chromatin binding namespace: biological_process def: "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf] is_a: GO:0035561 ! regulation of chromatin binding is_a: GO:0051100 ! negative regulation of binding [Term] id: GO:0035563 name: positive regulation of chromatin binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf] is_a: GO:0035561 ! regulation of chromatin binding is_a: GO:0051099 ! positive regulation of binding [Term] id: GO:0035564 name: regulation of kidney size namespace: biological_process def: "Any process that modulates the size of a kidney." [GOC:bf] is_a: GO:0090066 ! regulation of anatomical structure size relationship: part_of GO:0060993 ! kidney morphogenesis [Term] id: GO:0035565 name: regulation of pronephros size namespace: biological_process def: "Any process that modulates the size of a pronephric kidney." [GOC:bf] synonym: "regulation of pronephric kidney size" EXACT [GOC:bf] is_a: GO:0035564 ! regulation of kidney size relationship: part_of GO:0072114 ! pronephros morphogenesis [Term] id: GO:0035566 name: regulation of metanephros size namespace: biological_process def: "Any process that modulates the size of a metanephric kidney." [GOC:bf] synonym: "regulation of metanephric kidney size" EXACT [GOC:bf] is_a: GO:0035564 ! regulation of kidney size relationship: part_of GO:0003338 ! metanephros morphogenesis [Term] id: GO:0035567 name: non-canonical Wnt receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin." [GOC:signaling] comment: This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term. synonym: "beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:signaling] synonym: "non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway [Term] id: GO:0035568 name: N-terminal peptidyl-proline methylation namespace: biological_process def: "The methylation of the N-terminal proline of proteins." [PMID:20668449, RESID:AA0419] xref: RESID:AA0419 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0035569 name: N-terminal peptidyl-proline trimethylation namespace: biological_process def: "The trimethylation of the N-terminal proline of proteins to form the derivative N,N,N-trimethylproline." [PMID:20668449] comment: This term was made obsolete because N-terminal proline residues can not be trimethylated. is_obsolete: true [Term] id: GO:0035570 name: N-terminal peptidyl-serine methylation namespace: biological_process def: "The methylation of the N-terminal serine of proteins." [PMID:20668449] is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0035571 name: N-terminal peptidyl-serine monomethylation namespace: biological_process def: "The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine." [PMID:20668449] is_a: GO:0035570 ! N-terminal peptidyl-serine methylation [Term] id: GO:0035572 name: N-terminal peptidyl-serine dimethylation namespace: biological_process def: "The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine." [PMID:20668449] is_a: GO:0035570 ! N-terminal peptidyl-serine methylation [Term] id: GO:0035573 name: N-terminal peptidyl-serine trimethylation namespace: biological_process def: "The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine." [PMID:20668449] is_a: GO:0035570 ! N-terminal peptidyl-serine methylation [Term] id: GO:0035574 name: histone H4-K20 demethylation namespace: biological_process def: "The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone." [GOC:sp, PMID:20622853] is_a: GO:0070076 ! histone lysine demethylation [Term] id: GO:0035575 name: histone demethylase activity (H4-K20 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein." [EC:1.14.11.27, PMID:20622853] is_a: GO:0032452 ! histone demethylase activity [Term] id: GO:0035576 name: retinoic acid receptor signaling pathway involved in pronephric field specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in regions of the embryo being delineated into the area in which the pronephric kidney will develop." [GOC:bf, PMID:16979153, PMID:19909807] synonym: "retinoic acid receptor signalling pathway involved in pronephric field specification" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway relationship: part_of GO:0039003 ! pronephric field specification [Term] id: GO:0035577 name: azurophil granule membrane namespace: cellular_component def: "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] synonym: "primary granule membrane" EXACT [] is_a: GO:0005774 ! vacuolar membrane is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042582 ! azurophil granule [Term] id: GO:0035578 name: azurophil granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] synonym: "primary granule lumen" EXACT [] is_a: GO:0005775 ! vacuolar lumen is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0042582 ! azurophil granule [Term] id: GO:0035579 name: specific granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549] synonym: "secondary granule membrane" EXACT [] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042581 ! specific granule [Term] id: GO:0035580 name: specific granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549] synonym: "secondary granule lumen" EXACT [] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0042581 ! specific granule [Term] id: GO:0035581 name: extracellular sequestering of receptor ligand namespace: biological_process def: "The process of binding or confining a ligand for a receptor within the extracellular region, such that it is separated from other components of the signaling pathway." [GOC:BHF, PMID:20855508] synonym: "negative regulation of protein bioavailability" RELATED [GOC:BHF] is_a: GO:0071694 ! maintenance of protein location in extracellular region [Term] id: GO:0035582 name: negative regulation of BMP signaling pathway by extracellular sequestering of BMP namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by binding or confining BMP within the extracellular region, such that it is separated from other components of the signaling pathway." [GOC:BHF, PMID:20855508] synonym: "negative regulation of BMP signalling pathway by extracellular sequestering of BMP" EXACT [GOC:mah] synonym: "negative regulation of bone morphogenetic protein signaling pathway by extracellular sequestering of bone morphogenetic protein" EXACT [] is_a: GO:0030514 ! negative regulation of BMP signaling pathway is_a: GO:0035581 ! extracellular sequestering of receptor ligand [Term] id: GO:0035583 name: negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGFbeta receptor signaling pathway by binding or confining a TGFbeta protein within the extracellular region such that it is separated from other components of the signaling pathway." [GOC:BHF, PMID:20855508] synonym: "negative regulation of TGF-beta receptor signaling pathway by extracellular sequestering of TGF-beta protein" EXACT [] synonym: "negative regulation of transforming growth factor beta receptor signalling pathway by extracellular sequestering of TGFbeta" EXACT [GOC:mah] is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0035581 ! extracellular sequestering of receptor ligand [Term] id: GO:0035584 name: calcium-mediated signaling using intracellular calcium source namespace: biological_process def: "A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754] synonym: "calcium signaling using intracellular calcium source" EXACT [] synonym: "calcium signalling using intracellular calcium source" EXACT [] synonym: "calcium-mediated signalling using intracellular calcium source" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling [Term] id: GO:0035585 name: calcium-mediated signaling using extracellular calcium source namespace: biological_process def: "A series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754] synonym: "calcium signaling using extracellular calcium source" EXACT [] synonym: "calcium signalling using extracellular calcium source" EXACT [] synonym: "calcium-mediated signalling using extracellular calcium source" EXACT [] synonym: "extracellular calcium influx" NARROW [GOC:BHF] is_a: GO:0019722 ! calcium-mediated signaling [Term] id: GO:0035586 name: purinergic receptor activity namespace: molecular_function def: "Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) to initiate a change in cell activity." [GOC:bf, GOC:BHF, PMID:9755289] synonym: "purinoceptor" EXACT [PMID:9755289] synonym: "purinoreceptor" EXACT [PMID:9755289] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0035587 name: purinergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity." [GOC:BHF, PMID:9755289] synonym: "purinergic receptor signalling pathway" EXACT [GOC:mah] synonym: "purinoceptor signaling pathway" EXACT [PMID:9755289] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0035588 name: G-protein coupled purinergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:BHF, PMID:9755289] synonym: "G-protein coupled purinergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0035587 ! purinergic receptor signaling pathway [Term] id: GO:0035589 name: G-protein coupled purinergic nucleotide receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:BHF, PMID:9755289] synonym: "G-protein coupled purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah] synonym: "P2Y receptor signaling pathway" EXACT [PMID:9755289] is_a: GO:0035588 ! G-protein coupled purinergic receptor signaling pathway is_a: GO:0035590 ! purinergic nucleotide receptor signaling pathway [Term] id: GO:0035590 name: purinergic nucleotide receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity." [GOC:BHF, PMID:9755289] synonym: "P2 receptor signaling pathway" RELATED [PMID:9755289] synonym: "purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0035587 ! purinergic receptor signaling pathway [Term] id: GO:0035591 name: signaling adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf] comment: A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. synonym: "signalling adaptor activity" EXACT [GOC:mah] is_a: GO:0060090 ! binding, bridging [Term] id: GO:0035592 name: establishment of protein localization in extracellular region namespace: biological_process def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah] is_a: GO:0045184 ! establishment of protein localization relationship: part_of GO:0071692 ! protein localization in extracellular region [Term] id: GO:0035593 name: positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization in extracellular region namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the Wnt receptor signaling pathway by the directed movement of a Wnt protein within the extracellular region." [GOC:BHF, PMID:19906850] synonym: "positive regulation of Wnt diffusion" NARROW [PMID:19906850] synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localisation in extracellular region" EXACT [GOC:mah] synonym: "positive regulation of Wnt receptor signalling pathway by establishment of Wnt protein localization in extracellular region" EXACT [GOC:mah] synonym: "positive regulation of Wnt signaling range" RELATED [PMID:19906850] is_a: GO:0030177 ! positive regulation of Wnt receptor signaling pathway is_a: GO:0035592 ! establishment of protein localization in extracellular region [Term] id: GO:0035594 name: ganglioside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues." [GOC:yaf] is_a: GO:0043208 ! glycosphingolipid binding [Term] id: GO:0035595 name: N-acetylglucosaminylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol." [EC:3.5.1.103, GOC:rs] synonym: "GlcNAc-Ins deacetylase activity" EXACT [GOC:rs] synonym: "N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity" EXACT [EC:3.5.1.103] xref: EC:3.5.1.103 xref: MetaCyc:RXN1G-2 xref: RHEA:26183 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0035596 name: methylthiotransferase activity namespace: molecular_function def: "Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor." [GOC:jh2, PMID:20472640] synonym: "MTTase" EXACT [PMID:20472640] is_a: GO:0050497 ! transferase activity, transferring alkylthio groups [Term] id: GO:0035597 name: N6-isopentenyladenosine methylthiotransferase activity namespace: molecular_function def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A)." [PMID:20472640] synonym: "i6A methylthiotransferase activity" EXACT [PMID:20472640] is_a: GO:0035596 ! methylthiotransferase activity [Term] id: GO:0035598 name: N6-threonylcarbomyladenosine methylthiotransferase activity namespace: molecular_function def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)." [PMID:20472640, PMID:20584901] synonym: "t6A methylthiotransferase activity" EXACT [PMID:20472640] is_a: GO:0035596 ! methylthiotransferase activity [Term] id: GO:0035599 name: aspartic acid methylthiotransferase activity namespace: molecular_function def: "Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid." [PMID:18252828, PMID:8844851, RESID:AA0232] comment: Note that peptidyl-L-beta-methylthioaspartic acid is typical of bacterial ribosomal protein S12. xref: RESID:AA0232 is_a: GO:0035596 ! methylthiotransferase activity [Term] id: GO:0035600 name: tRNA methylthiolation namespace: biological_process def: "The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule." [PMID:20472640] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0035601 name: protein deacylation namespace: biological_process def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046] synonym: "protein amino acid deacylation" EXACT [GOC:se] is_a: GO:0006464 ! protein modification process [Term] id: GO:0035602 name: fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptosis in the bone marrow." [GOC:yaf] synonym: "FGF receptor signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf] synonym: "FGFR signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0071866 ! negative regulation of apoptosis in bone marrow [Term] id: GO:0035603 name: fibroblast growth factor receptor signaling pathway involved in hemopoiesis namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis." [GOC:yaf] synonym: "FGF receptor signaling pathway involved in hematopoiesis" EXACT [GOC:bf] synonym: "FGFR signaling pathway involved in hematopoiesis" EXACT [GOC:bf] synonym: "fibroblast growth factor receptor signaling pathway involved in hematopoiesis" EXACT [GOC:yaf] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0035604 name: fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:yaf] synonym: "FGF receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf] synonym: "FGFR signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0071864 ! positive regulation of cell proliferation in bone marrow [Term] id: GO:0035605 name: peptidyl-cysteine S-nitrosylase activity namespace: molecular_function def: "Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein." [EC:2.6.99.-, GOC:sp, PMID:20972425, PMID:20972426] comment: This term should not be used to annotate the nitrosylating action of nitric oxide synthase (NOS) if the nitroso group is synthesized directly on the substrate. synonym: "protein nitrosylase activity" RELATED [GOC:sp] synonym: "S-nitrosylase activity" EXACT [PMID:20972426] is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0035606 name: peptidyl-cysteine S-trans-nitrosylation namespace: biological_process def: "Transfer of a nitric oxide (NO) group from one cysteine residue to another." [PMID:19854201, PMID:20972425, PMID:20972426] synonym: "cysteine to cysteine nitrosylation" EXACT [PMID:20972426] synonym: "cysteine-to-cysteine transnitrosylation" EXACT [PMID:20972426] synonym: "protein-to-protein transnitrosylation" BROAD [PMID:20972426] synonym: "S-transnitrosylation" EXACT [PMID:20972426] is_a: GO:0018119 ! peptidyl-cysteine S-nitrosylation [Term] id: GO:0035607 name: fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state." [GOC:yaf] synonym: "FGF receptor signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf] synonym: "FGFR signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf] synonym: "fibroblast growth factor receptor signalling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0021769 ! orbitofrontal cortex development [Term] id: GO:0035608 name: protein deglutamylation namespace: biological_process def: "The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation." [GOC:sp, PMID:21074048] synonym: "protein amino acid deglutamylation" EXACT [GOC:bf] is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0035609 name: C-terminal protein deglutamylation namespace: biological_process def: "The removal of a C-terminal, gene-encoded glutamate residue from a protein." [GOC:sp, PMID:21074048] synonym: "protein primary sequence deglutamylation" EXACT [PMID:21074048] is_a: GO:0018410 ! C-terminal protein amino acid modification is_a: GO:0035608 ! protein deglutamylation [Term] id: GO:0035610 name: protein side chain deglutamylation namespace: biological_process def: "The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation." [GOC:sp, PMID:21074048] synonym: "removal of posttranslational polyglutamylation" EXACT [PMID:21074048] synonym: "shortening of glutamate side chain" RELATED [PMID:21074048] is_a: GO:0035608 ! protein deglutamylation [Term] id: GO:0035611 name: protein branching point deglutamylation namespace: biological_process def: "The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue." [GOC:sp, PMID:21074048] is_a: GO:0035608 ! protein deglutamylation [Term] id: GO:0035612 name: AP-2 adaptor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499] synonym: "AP-2 clathrin adaptor complex binding" RELATED [GOC:bf] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0035613 name: RNA stem-loop binding namespace: molecular_function def: "Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] synonym: "RNA hairpin binding" EXACT [PMID:16568238] synonym: "RNA hairpin loop binding" EXACT [PMID:16568238] is_a: GO:0003723 ! RNA binding [Term] id: GO:0035614 name: snRNA stem-loop binding namespace: molecular_function def: "Interacting selectively and non-covalently with a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] synonym: "small nuclear RNA stem-loop binding" EXACT [] synonym: "snRNA hairpin binding" EXACT [PMID:16568238] synonym: "snRNA hairpin loop binding" EXACT [PMID:16568238] is_a: GO:0017069 ! snRNA binding is_a: GO:0035613 ! RNA stem-loop binding [Term] id: GO:0035615 name: clathrin adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way." [GOC:BHF, PMID:15728179] synonym: "clathrin-associated adaptor activity" EXACT [PMID:15728179] is_a: GO:0030276 ! clathrin binding is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0035616 name: histone H2B conserved C-terminal lysine deubiquitination namespace: biological_process def: "A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:bf, GOC:vw, PMID:15657442] synonym: "budding yeast H2B K123 deubiquitination" NARROW [GOC:vw] synonym: "fission yeast H2B K119 deubiquitination" NARROW [GOC:vw] synonym: "mammalian H2B K120 deubiquitination" NARROW [GOC:vw] is_a: GO:0016578 ! histone deubiquitination [Term] id: GO:0035617 name: stress granule disassembly namespace: biological_process def: "The disaggregation of a stress granule into its constituent protein and RNA parts." [GOC:BHF, PMID:19825938] synonym: "SG disassembly" EXACT [PMID:19825938] is_a: GO:0032988 ! ribonucleoprotein complex disassembly [Term] id: GO:0035618 name: root hair namespace: cellular_component def: "A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall." [http://www.jstor.org/stable/4354264, PO:0000256] comment: This term is a child of 'cell projection' and not 'cell hair' to distinguish it from animal cell hairs, which are morphologically distinct. is_a: GO:0042995 ! cell projection [Term] id: GO:0035619 name: root hair tip namespace: cellular_component def: "The tip portion of an outgrowth of a root epidermal cell." [PO:0000029] synonym: "root hair cell tip" EXACT [] is_a: GO:0044463 ! cell projection part relationship: part_of GO:0035618 ! root hair [Term] id: GO:0035620 name: ceramide transporter activity namespace: molecular_function def: "Enables the directed movement of ceramides into, out of or within a cell, or between cells. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229] is_a: GO:0046624 ! sphingolipid transporter activity [Term] id: GO:0035621 name: ER to Golgi ceramide transport namespace: biological_process def: "The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229] synonym: "endoplasmic reticulum to Golgi ceramide transport" EXACT [GOC:bf] synonym: "ER to Golgi ceramide translocation" EXACT [PMID:14685229] synonym: "non-vesicular ceramide trafficking" EXACT [PMID:14685229] is_a: GO:0032365 ! intracellular lipid transport is_a: GO:0035627 ! ceramide transport [Term] id: GO:0035622 name: intrahepatic bile duct development namespace: biological_process def: "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver)." [GOC:bf, PMID:20614624] synonym: "IHBD development" EXACT [PMID:20614624] synonym: "intrahepatic biliary duct development" EXACT [PMID:20614624] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001889 ! liver development [Term] id: GO:0035623 name: renal glucose absorption namespace: biological_process def: "A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron." [GOC:yaf, PMID:11269503] synonym: "glucose reabsorption" EXACT [GOC:yaf] synonym: "nephron glucose absorption" EXACT [GOC:yaf] is_a: GO:0015758 ! glucose transport is_a: GO:0070293 ! renal absorption [Term] id: GO:0035624 name: receptor transactivation namespace: biological_process def: "The process in which a receptor is activated via signaling events from a receptor for a different ligand. Receptor transactivation is an example of cross-talk between signaling pathways and can occur through several different mechanisms." [GOC:bf, GOC:BHF, PMID:16870826] is_a: GO:2000273 ! positive regulation of receptor activity [Term] id: GO:0035625 name: epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway namespace: biological_process def: "The process in which an epidermal growth factor receptor is activated via signaling events from a G-protein coupled receptor. This is an example of cross-talk between the EGFR and GPCR signaling pathways." [GOC:bf, GOC:BHF, PMID:10622253, PMID:17655843] synonym: "EGFR transactivation by GPCR" EXACT [GOC:bf] synonym: "EGFR transactivation upon GPCR stimulation" EXACT [PMID:10622253] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0035624 ! receptor transactivation is_a: GO:0045741 ! positive regulation of epidermal growth factor receptor activity [Term] id: GO:0035626 name: juvenile hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart] synonym: "juvenile hormone mediated signalling pathway" EXACT [GOC:bf] synonym: "juvenile hormone-mediated signaling pathway" EXACT [GOC:bf] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0035627 name: ceramide transport namespace: biological_process def: "The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:bf, GOC:sart] is_a: GO:0006869 ! lipid transport [Term] id: GO:0035628 name: cystic duct development namespace: biological_process def: "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gall bladder to the common bile duct." [PMID:20614624] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061008 ! hepaticobiliary system development [Term] id: GO:0035629 name: N-terminal protein amino acid N-linked glycosylation namespace: biological_process def: "Addition of a sugar unit via a nitrogen (N) atom of the N-terminal amino acid of a protein." [GOC:bf] comment: Note that the only known alpha amino glycosylation is on an asparagine; see UniProtKB:P58522. However, this feature is not differentiated from normal N-glycosylation of asparagine. is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0035630 name: bone mineralization involved in bone maturation namespace: biological_process def: "The deposition of calcium phosphate in bone tissue, involved in the progression of the skeleton from its formation to its mature state." [GOC:bf, GOC:BHF] comment: Bone mineralization can also occur after a fracture and as a response to stress; in these cases, consider using the term 'bone mineralization ; GO:0030282'. is_a: GO:0030282 ! bone mineralization relationship: part_of GO:0043931 ! ossification involved in bone maturation [Term] id: GO:0035631 name: CD40 receptor complex namespace: cellular_component def: "A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules." [GOC:BHF, PMID:20614026, PMID:9221764] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0035632 name: mitochondrial prohibitin complex namespace: cellular_component def: "A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death." [GOC:kmv, PMID:12237468, PMID:21164222] synonym: "mitochondrial inner membrane prohibitin complex" EXACT [GOC:bf] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0035633 name: maintenance of blood-brain barrier namespace: biological_process def: "Preserving the permeability barrier between the blood and the brain in a stable functional or structural state. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:bf, GOC:sl, PMID:20080302] synonym: "maintenance of BBB" EXACT [PMID:20080302] is_a: GO:0009987 ! cellular process [Term] id: GO:0035634 name: response to stilbenoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones." [CHEBI:26776, GOC:yaf, http://en.wikipedia.org/wiki/Stilbenoid] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0035635 name: entry of bacterium into host cell namespace: biological_process def: "The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:21187937] synonym: "bacterial entry into host cell" EXACT [GOC:bf] synonym: "invasion of bacteria into host cell" EXACT [GOC:bf] is_a: GO:0030260 ! entry into host cell [Term] id: GO:0035636 name: multi-organism signaling namespace: biological_process def: "The transfer of information between living organisms." [GOC:go_curators] synonym: "multi-organism signalling" EXACT [GOC:bf] synonym: "pheromone signaling" NARROW [GOC:bf] synonym: "signaling between organisms" EXACT [GOC:bf] synonym: "signaling with other organism" EXACT [GOC:bf] is_a: GO:0023052 ! signaling is_a: GO:0051704 ! multi-organism process [Term] id: GO:0035637 name: multicellular organismal signaling namespace: biological_process def: "The transfer of information occurring at the level of a multicellular organism." [GOC:go_curators] synonym: "multicellular organismal signalling" EXACT [GOC:bf] is_a: GO:0023052 ! signaling is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0035638 name: signal maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a signal. A signal is a physical entity or change in state that is used to transfer information to trigger a response, and is functional when it can activate a receptor." [GOC:bf, GOC:pde, GOC:signaling] synonym: "ligand maturation" NARROW [GOC:bf] is_a: GO:0009987 ! cellular process relationship: part_of GO:0023056 ! positive regulation of signaling [Term] id: GO:0035639 name: purine ribonucleoside triphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [CHEBI:26398, GOC:BHF, GOC:ebc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "purine NTP binding" BROAD [GOC:ebc] is_a: GO:0032555 ! purine ribonucleotide binding [Term] id: GO:0035640 name: exploration behavior namespace: biological_process def: "The specific actions or reactions of an organism in response to a novel environment or stimulus." [GOC:BHF, PMID:11682103, PMID:9767169] comment: For changes in locomotory behavior upon introduction to a novel environment, consider instead the child term: locomotory exploration behavior ; GO:0035641. synonym: "exploration behaviour" EXACT [GOC:bf] synonym: "exploratory behavior" EXACT [PMID:20869398] synonym: "exploratory behaviour" EXACT [PMID:11682103] synonym: "open-field behavior" NARROW [PMID:11682103] is_a: GO:0007610 ! behavior [Term] id: GO:0035641 name: locomotory exploration behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to a novel environment." [GOC:sart, PMID:17151232] is_a: GO:0007626 ! locomotory behavior is_a: GO:0035640 ! exploration behavior [Term] id: GO:0035642 name: histone methyltransferase activity (H3-R17 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3." [GOC:sp, PMID:11341840] synonym: "histone methylase activity (H3-R17 specific)" EXACT [GOC:bf] synonym: "histone-arginine N-methyltransferase activity (H3-R17 specific)" EXACT [GOC:bf] is_a: GO:0008469 ! histone-arginine N-methyltransferase activity [Term] id: GO:0035643 name: L-DOPA receptor activity namespace: molecular_function def: "Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine." [CHEBI:15765, http://en.wikipedia.org/wiki/L-DOPA, PMID:18828673] synonym: "L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity" EXACT [CHEBI:15765] synonym: "L-dopa receptor activity" EXACT [CHEBI:15765] is_a: GO:0008188 ! neuropeptide receptor activity is_a: GO:0072544 ! L-DOPA binding [Term] id: GO:0035644 name: phosphoanandamide dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from a phosphorylated anandamide." [CHEBI:2700, GOC:BHF, PMID:16938887] is_a: GO:0016311 ! dephosphorylation [Term] id: GO:0035645 name: enteric smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine." [CL:0002504, GOC:BHF] synonym: "intestinal smooth muscle cell differentiation" EXACT [CL:0002504] is_a: GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0035646 name: endosome to melanosome transport namespace: biological_process def: "The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle." [PMID:16162817] is_a: GO:0016197 ! endosome transport [Term] id: GO:0035647 name: 3-oxo-delta(4,5)-steroid 5-beta-reductase activity namespace: molecular_function def: "Definition: Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H(+) = a 5-beta-3-oxo-steroid + NADP(+)." [GOC:kad, MetaCyc:RXN-9726, PMID:19166903] synonym: "3-oxo-Delta4,5-steroid 5beta-reductase" EXACT [GOC:kad] is_a: GO:0035671 ! enone reductase activity [Term] id: GO:0035648 name: circadian mating behavior namespace: biological_process def: "The fluctuation in mating behavior that occurs over an approximately 24 hour cycle." [GOC:bf, GOC:dos, PMID:11470898, PMID:17276917] synonym: "circadian mating behaviour" EXACT [GOC:bf] synonym: "circadian mating rhythm" EXACT [GOC:dos] is_a: GO:0007617 ! mating behavior is_a: GO:0048512 ! circadian behavior [Term] id: GO:0035649 name: Nrd1 complex namespace: cellular_component def: "A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p." [GOC:jh, PMID:10655211, PMID:16427013, PMID:21084293] is_a: GO:0043234 ! protein complex [Term] id: GO:0035650 name: AP-1 adaptor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [PMID:21097499] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0035651 name: AP-3 adaptor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [PMID:21097499] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0035652 name: cargo loading into clathrin-coated vesicle namespace: biological_process def: "Formation of a protein complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins that are going to be transported by a vesicle." [PMID:16162817] is_a: GO:0035459 ! cargo loading into vesicle [Term] id: GO:0035653 name: cargo loading into clathrin-coated vesicle, AP-1-mediated namespace: biological_process def: "Formation of a protein complex between proteins of the AP-1 adaptor complex and proteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking." [PMID:12802059, PMID:16162817] is_a: GO:0035652 ! cargo loading into clathrin-coated vesicle [Term] id: GO:0035654 name: cargo loading into clathrin-coated vesicle, AP-3-mediated namespace: biological_process def: "Formation of a protein complex between proteins of the AP-3 adaptor complex and proteins that are going to be transported by a clathrin-coated vesicle. In some cases, The AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle." [PMID:12802059, PMID:16162817] is_a: GO:0035652 ! cargo loading into clathrin-coated vesicle [Term] id: GO:0035655 name: interleukin-18-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor." [GOC:bf, GOC:BHF] synonym: "interleukin-18-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway is_a: GO:0071351 ! cellular response to interleukin-18 [Term] id: GO:0035656 name: kinesin-associated melanosomal adaptor activity namespace: molecular_function def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to melanosomes." [PMID:19841138] synonym: "kinesin-melanosome adaptor activity" EXACT [GOC:bf] is_a: GO:0019894 ! kinesin binding is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0035657 name: eRF1 methyltransferase complex namespace: cellular_component def: "A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p." [GOC:rb, PMID:17008308, PMID:20400505] synonym: "eRF1 MTase complex" EXACT [PMID:17008308] is_a: GO:0034708 ! methyltransferase complex [Term] id: GO:0035658 name: Mon1-Ccz1 complex namespace: cellular_component def: "A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862] is_a: GO:0043234 ! protein complex is_a: GO:0044440 ! endosomal part relationship: part_of GO:0005770 ! late endosome [Term] id: GO:0035659 name: Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis." [GOC:BHF] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0035313 ! wound healing, spreading of epidermal cells [Term] id: GO:0035660 name: MyD88-dependent toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834, PMID:20385024] synonym: "MyD88-dependent TLR4 signaling pathway" EXACT [GOC:bf] synonym: "MyD88-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway is_a: GO:0034142 ! toll-like receptor 4 signaling pathway [Term] id: GO:0035661 name: MyD88-dependent toll-like receptor 2 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response." [GOC:BHF, PMID:20385024] synonym: "MyD88-dependent TLR2 signaling pathway" EXACT [GOC:bf] synonym: "MyD88-dependent toll-like receptor 2 signalling pathway" EXACT [GOC:bf] is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway is_a: GO:0034134 ! toll-like receptor 2 signaling pathway [Term] id: GO:0035662 name: Toll-like receptor 4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834] synonym: "TLR4 binding" EXACT [GOC:bf] is_a: GO:0035325 ! Toll-like receptor binding [Term] id: GO:0035663 name: Toll-like receptor 2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response." [GOC:BHF] synonym: "TLR2 binding" EXACT [GOC:bf] is_a: GO:0035325 ! Toll-like receptor binding [Term] id: GO:0035664 name: TIRAP-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:11526399, PMID:11544529, PMID:12447442] synonym: "MAL-dependent toll-like receptor signaling pathway" EXACT [PMID:11544529] synonym: "MyD88 adapter-like dependent toll-like receptor signaling pathway" EXACT [PMID:11544529] synonym: "TIRAP-dependent TLR signaling pathway" EXACT [GOC:bf] synonym: "TIRAP-dependent toll-like receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0035665 name: TIRAP-dependent toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:12447441] synonym: "MAL-dependent toll-like receptor 4 signaling pathway" EXACT [PMID:11544529] synonym: "MyD88 adapter-like dependent toll-like receptor 4 signaling pathway" EXACT [GOC:11544529] synonym: "TIRAP-dependent TLR4 signaling pathway" EXACT [GOC:bf] synonym: "TIRAP-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] is_a: GO:0034142 ! toll-like receptor 4 signaling pathway is_a: GO:0035664 ! TIRAP-dependent toll-like receptor signaling pathway [Term] id: GO:0035666 name: TRIF-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:12855817] synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway" EXACT [PMID:12855817] synonym: "TRIF-dependent TLR signaling pathway" EXACT [GOC:bf] synonym: "TRIF-dependent toll-like receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway [Term] id: GO:0035667 name: TRIF-dependent toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18641322, PMID:20511708] synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR4 signaling pathway" EXACT [PMID:12855817] synonym: "TRIF-dependent TLR4 signaling pathway" EXACT [GOC:bf] synonym: "TRIF-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] is_a: GO:0034142 ! toll-like receptor 4 signaling pathway is_a: GO:0035666 ! TRIF-dependent toll-like receptor signaling pathway [Term] id: GO:0035668 name: TRAM-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:14556004] synonym: "TRAM-dependent TLR signaling pathway" EXACT [GOC:bf] synonym: "TRAM-dependent toll-like receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway [Term] id: GO:0035669 name: TRAM-dependent toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:14556004, PMID:18297073] synonym: "TRAM-dependent TLR4 signaling pathway" EXACT [GOC:bf] synonym: "TRAM-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] is_a: GO:0034142 ! toll-like receptor 4 signaling pathway is_a: GO:0035668 ! TRAM-dependent toll-like receptor signaling pathway [Term] id: GO:0035670 name: ovule-producing ovary development namespace: biological_process def: "The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed." [GOC:bf, GOC:tb, ISBN:0879015322] is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0048440 ! carpel development [Term] id: GO:0035671 name: enone reductase activity namespace: molecular_function def: "Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+." [GOC:kad, PMID:17945329, PMID:19166903] is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0035672 name: oligopeptide transmembrane transport namespace: biological_process def: "The directed movement of an oligopeptide across a membrane by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0006857 ! oligopeptide transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035673 name: oligopeptide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oligopeptides from one side of the membrane to the other." [GOC:vw] is_a: GO:0015198 ! oligopeptide transporter activity is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0035674 name: tricarboxylic acid transmembrane transport namespace: biological_process def: "The process in which tricarboxylic acids are transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0006842 ! tricarboxylic acid transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0035675 name: neuromast hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0000856] is_a: GO:0048666 ! neuron development relationship: part_of GO:0048886 ! neuromast hair cell differentiation [Term] id: GO:0035676 name: anterior lateral line neuromast hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509, ISBN:0387968377] is_a: GO:0035675 ! neuromast hair cell development relationship: part_of GO:0048903 ! anterior lateral line neuromast hair cell differentiation [Term] id: GO:0035677 name: posterior lateral line neuromast hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509] is_a: GO:0035675 ! neuromast hair cell development relationship: part_of GO:0048923 ! posterior lateral line neuromast hair cell differentiation [Term] id: GO:0035678 name: neuromast hair cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [CL:0000856] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0035675 ! neuromast hair cell development [Term] id: GO:0035679 name: anterior lateral line neuromast hair cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509, ISBN:0387968377] is_a: GO:0035678 ! neuromast hair cell morphogenesis relationship: part_of GO:0035676 ! anterior lateral line neuromast hair cell development [Term] id: GO:0035680 name: posterior lateral line neuromast hair cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509] is_a: GO:0035678 ! neuromast hair cell morphogenesis relationship: part_of GO:0035677 ! posterior lateral line neuromast hair cell development [Term] id: GO:0035681 name: toll-like receptor 15 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 15." [GOC:pde] synonym: "TLR15 signaling pathway" EXACT [GOC:bf] xref: Reactome:451529 "TLR15 cascade" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0035682 name: toll-like receptor 21 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 21." [GOC:pde] synonym: "TLR21 signaling pathway" EXACT [GOC:bf] xref: Reactome:451531 "TLR21 cascade" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0035683 name: memory T cell extravasation namespace: biological_process def: "The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [CL:0000813, GOC:BHF] synonym: "memory T-cell extravasation" EXACT [GOC:ebc] is_a: GO:0072683 ! T cell extravasation [Term] id: GO:0035684 name: helper T cell extravasation namespace: biological_process def: "The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells." [CL:0000912, GOC:BHF] synonym: "helper T-cell extravasation" EXACT [GOC:ebc] synonym: "T-helper cell extravasation" EXACT [CL:0000912] is_a: GO:0072683 ! T cell extravasation [Term] id: GO:0035685 name: helper T cell diapedesis namespace: biological_process def: "The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [CL:0000912, GOC:BHF] synonym: "helper T-cell diapedesis" EXACT [CL:0000912] synonym: "T-helper cell diapedesis" EXACT [CL:0000912] is_a: GO:0050904 ! diapedesis relationship: part_of GO:0035684 ! helper T cell extravasation [Term] id: GO:0035686 name: flagellar fibrous sheath namespace: cellular_component def: "A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat." [GOC:BHF, PMID:20731842, PMID:3282552] synonym: "flagellum fibrous sheath" EXACT [GOC:bf] is_a: GO:0044442 ! microtubule-based flagellum part [Term] id: GO:0035687 name: T-helper 1 cell extravasation namespace: biological_process def: "The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF] synonym: "Th1 cell extravasation" EXACT [CL:0000545] is_a: GO:0035684 ! helper T cell extravasation [Term] id: GO:0035688 name: T-helper 1 cell diapedesis namespace: biological_process def: "The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF, PMID:10477596] synonym: "Th1 cell diapedesis" EXACT [CL:0000545] is_a: GO:0035685 ! helper T cell diapedesis relationship: part_of GO:0035687 ! T-helper 1 cell extravasation [Term] id: GO:0035689 name: chemokine (C-C motif) ligand 5 signaling pathway namespace: biological_process def: "A series of molecular events generated as a consequence of the chemokine CCL5 binding to a cell surface receptor." [GOC:BHF, PMID:18337562] synonym: "CCL5-mediated signaling pathway" EXACT [PMID:18337562] synonym: "RANTES-mediated signaling pathway" EXACT [PMID:19122644] is_a: GO:0070098 ! chemokine-mediated signaling pathway [Term] id: GO:0035690 name: cellular response to drug namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:sl] is_a: GO:0042493 ! response to drug is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0035691 name: macrophage migration inhibitory factor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of macrophage migration inhibitory factor binding to a cell surface receptor." [GOC:BHF, PMID:12782713, PMID:19413900] synonym: "MIF signaling pathway" EXACT [GOC:ebc] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0035692 name: macrophage migration inhibitory factor receptor complex namespace: cellular_component def: "A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins." [GOC:BHF, PMID:12782713, PMID:17045821] is_a: GO:0043235 ! receptor complex [Term] id: GO:0035693 name: NOS2-CD74 complex namespace: cellular_component def: "A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases." [GOC:BHF, PMID:18003616] is_a: GO:0043234 ! protein complex [Term] id: GO:0035694 name: mitochondrial protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure." [GOC:sp, PMID:21264221, PMID:21264228] synonym: "catabolism of mitochondrial protein" EXACT [GOC:bf] synonym: "degradation of damaged mitochondrial protein" EXACT [GOC:bf] is_a: GO:0044257 ! cellular protein catabolic process relationship: part_of GO:0007005 ! mitochondrion organization [Term] id: GO:0035695 name: mitochondrion degradation by induced vacuole formation namespace: biological_process def: "The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes." [GOC:bf, GOC:sp, PMID:21264228] comment: In this mechanism of mitochondrion degradation, the mitochondrion is directly engulfed by a lysosome-like vacuole. It is therefore distinct from canonical autophagy, which is mediated by a double-membrane autophagosome. synonym: "MIV-mediated mitophagy" NARROW [PMID:21264228] is_a: GO:0000422 ! mitochondrion degradation [Term] id: GO:0035696 name: monocyte extravasation namespace: biological_process def: "The migration of a monocyte from the blood vessels into the surrounding tissue." [CL:0000576, GOC:BHF, PMID:10657654] is_a: GO:0045123 ! cellular extravasation [Term] id: GO:0035697 name: CD8-positive, alpha-beta T cell extravasation namespace: biological_process def: "The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue." [CL:0000625, GOC:BHF] is_a: GO:0072683 ! T cell extravasation [Term] id: GO:0035698 name: CD8-positive, alpha-beta cytotoxic T cell extravasation namespace: biological_process def: "The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue." [CL:0000794, GOC:BHF] is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation [Term] id: GO:0035699 name: T-helper 17 cell extravasation namespace: biological_process def: "The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue." [CL:0000899, GOC:BHF] is_a: GO:0035684 ! helper T cell extravasation [Term] id: GO:0035700 name: astrocyte chemotaxis namespace: biological_process def: "The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000127, GOC:BHF, PMID:12271471] is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0035701 name: hematopoietic stem cell migration namespace: biological_process def: "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:BHF, PMID:20234092] synonym: "hemopoietic stem cell migration" EXACT [CL:0000037] is_a: GO:0016477 ! cell migration [Term] id: GO:0035702 name: monocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000576, GOC:BHF, PMID:18832716] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0035703 name: monocyte migration into blood stream namespace: biological_process def: "The movement of a monocyte from the bone marrow to the blood stream." [CL:0000576, GOC:BHF] synonym: "release of monocytes into circulation" EXACT [GOC:bf] is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0035704 name: helper T cell chemotaxis namespace: biological_process def: "The directed movement of a helper T cell in response to an external stimulus." [CL:0000912, GOC:BHF] synonym: "T-helper cell chemotaxis" EXACT [CL:0000912] is_a: GO:0010818 ! T cell chemotaxis [Term] id: GO:0035705 name: T-helper 17 cell chemotaxis namespace: biological_process def: "The directed movement of a T-helper 17 cell in response to an external stimulus." [CL:0000899, GOC:BHF] synonym: "Th17 cell chemotaxis" EXACT [CL:0000899] is_a: GO:0035704 ! helper T cell chemotaxis [Term] id: GO:0035706 name: T-helper 1 cell chemotaxis namespace: biological_process def: "The directed movement of a T-helper 1 cell in response to an external stimulus." [CL:0000545, GOC:BHF] synonym: "Th1 cell chemotaxis" EXACT [CL:0000545] is_a: GO:0035704 ! helper T cell chemotaxis [Term] id: GO:0035707 name: T-helper 2 cell chemotaxis namespace: biological_process def: "The directed movement of a T-helper 2 cell in response to an external stimulus." [CL:0000546, GOC:BHF] synonym: "Th2 cell chemotaxis" EXACT [CL:0000546] is_a: GO:0035704 ! helper T cell chemotaxis [Term] id: GO:0035708 name: interleukin-4-dependent isotype switching to IgE isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4)." [GOC:BHF, PMID:12496423] synonym: "IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:add, GOC:bf] is_a: GO:0048289 ! isotype switching to IgE isotypes [Term] id: GO:0035709 name: memory T cell activation namespace: biological_process def: "The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000813, GOC:BHF] is_a: GO:0042110 ! T cell activation [Term] id: GO:0035710 name: CD4-positive, alpha-beta T cell activation namespace: biological_process def: "The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000624, GOC:BHF] is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0035711 name: T-helper 1 cell activation namespace: biological_process def: "The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000545, GOC:BHF] synonym: "Th1 cell activation" EXACT [CL:0000545] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation [Term] id: GO:0035712 name: T-helper 2 cell activation namespace: biological_process def: "The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000546, GOC:BHF] synonym: "Th2 cell activation" EXACT [CL:0000546] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation [Term] id: GO:0035713 name: response to nitrogen dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [CHEBI:33101, GOC:BHF] synonym: "response to NO2" EXACT [CHEBI:33101] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0035714 name: cellular response to nitrogen dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [CHEBI:33101, GOC:BHF] synonym: "cellular response to NO2" EXACT [CHEBI:33101] is_a: GO:0035713 ! response to nitrogen dioxide is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0035715 name: chemokine (C-C motif) ligand 2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 2." [GOC:BHF] synonym: "CCL2 binding" EXACT [GOC:ebc] is_a: GO:0019957 ! C-C chemokine binding [Term] id: GO:0035716 name: chemokine (C-C motif) ligand 12 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 12." [GOC:BHF] synonym: "CCL12 binding" EXACT [GOC:ebc] is_a: GO:0019957 ! C-C chemokine binding [Term] id: GO:0035717 name: chemokine (C-C motif) ligand 7 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 7." [GOC:BHF] synonym: "CCL7 binding" EXACT [GOC:ebc] is_a: GO:0019957 ! C-C chemokine binding [Term] id: GO:0035718 name: macrophage migration inhibitory factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor." [GOC:BHF, PMID:19601712] synonym: "MIF binding" EXACT [PMID:19601712] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0035719 name: tRNA import into nucleus namespace: biological_process def: "The directed movement of tRNA from the cytoplasm to the nucleus." [GOC:vw, PMID:20032305] synonym: "retrograde tRNA transport into nucleus" EXACT [GOC:vw, PMID:20032305] synonym: "tRNA nuclear import" EXACT [GOC:vw] is_a: GO:0006404 ! RNA import into nucleus is_a: GO:0051031 ! tRNA transport [Term] id: GO:0035720 name: intraflagellar anterograde transport namespace: biological_process def: "The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium or flagellum, mediated by motor proteins." [GOC:BHF, PMID:17895364] is_a: GO:0042073 ! intraflagellar transport [Term] id: GO:0035721 name: intraflagellar retrograde transport namespace: biological_process def: "The directed movement of large protein complexes along microtubules from the tip of a cilium or flagellum toward the cell body, mediated by motor proteins." [GOC:BHF] is_a: GO:0042073 ! intraflagellar transport [Term] id: GO:0035722 name: interleukin-12-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of interleukin-12 binding to a cell surface receptor." [GOC:BHF] synonym: "IL-12-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-12-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway is_a: GO:0071349 ! cellular response to interleukin-12 [Term] id: GO:0035723 name: interleukin-15-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of interleukin-15 binding to a cell surface receptor." [GOC:BHF] synonym: "IL-15-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-15-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway is_a: GO:0071350 ! cellular response to interleukin-15 [Term] id: GO:0035724 name: CD24 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation." [GOC:BHF] synonym: "CD24 anabolism" EXACT [GOC:bf] synonym: "CD24 biosynthesis" EXACT [GOC:bf] synonym: "CD24 formation" EXACT [GOC:bf] synonym: "CD24 synthesis" EXACT [GOC:bf] is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0035725 name: sodium ion transmembrane transport namespace: biological_process def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] is_a: GO:0006814 ! sodium ion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0035726 name: common myeloid progenitor cell proliferation namespace: biological_process def: "The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage." [CL:0000049, GOC:BHF] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0035727 name: lysophosphatidic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G-protein-coupled receptors." [CHEBI:52288] synonym: "LPA binding" EXACT [CHEBI:52288] is_a: GO:0005504 ! fatty acid binding [Term] id: GO:0035728 name: response to hepatocyte growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf] synonym: "response to HGF stimulus" EXACT [GOC:bf] is_a: GO:0070848 ! response to growth factor stimulus [Term] id: GO:0035729 name: cellular response to hepatocyte growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf] synonym: "cellular response to HGF stimulus" EXACT [GOC:bf] is_a: GO:0035728 ! response to hepatocyte growth factor stimulus is_a: GO:0071363 ! cellular response to growth factor stimulus [Term] id: GO:0035730 name: S-nitrosoglutathione binding namespace: molecular_function def: "Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems." [CHEBI:50091, GOC:BHF] synonym: "GSNO binding" EXACT [CHEBI:50091] is_a: GO:0005488 ! binding [Term] id: GO:0035731 name: dinitrosyl-iron complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions." [GOC:BHF, PMID:10534443] synonym: "dinitrosyl-diglutathionyl-iron complex binding" EXACT [PMID:12871931] synonym: "DNDGIC binding" EXACT [PMID:12871931] synonym: "DNIC binding" EXACT [PMID:10534443] is_a: GO:0005488 ! binding [Term] id: GO:0035732 name: nitric oxide storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins." [GOC:BHF, PMID:12871945] synonym: "NO storage" EXACT [GOC:bf] is_a: GO:0051179 ! localization relationship: part_of GO:0033484 ! nitric oxide homeostasis [Term] id: GO:0035733 name: hepatic stellate cell activation namespace: biological_process def: "A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor." [CL:0000632, GOC:bf] is_a: GO:0072537 ! fibroblast activation [Term] id: GO:0035734 name: intraflagellar transport involved in flagellum organisation namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a flagellum that contributes to flagellum organisation." [GOC:bf] is_a: GO:0042073 ! intraflagellar transport relationship: part_of GO:0043064 ! flagellum organization [Term] id: GO:0035735 name: intraflagellar transport involved in cilium morphogenesis namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium morphogenesis." [GOC:bf] is_a: GO:0042073 ! intraflagellar transport relationship: part_of GO:0060271 ! cilium morphogenesis [Term] id: GO:0035736 name: cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0035737 name: injection of substance in to other organism namespace: biological_process def: "The process of forcing a substance into another organism, either by penetrating the skin of the other organism or by applying the substance externally to a sensitive tissue such as those that surround the eyes." [GOC:pamgo_curators] is_a: GO:0051705 ! behavioral interaction between organisms [Term] id: GO:0035738 name: envenomation namespace: biological_process def: "The process by which venom is forced into an organism by the bite or sting of another organism." [GOC:pamgo_curators] is_a: GO:0035737 ! injection of substance in to other organism [Term] id: GO:0035739 name: CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of a CD4-positive, alpha-beta T cell population by cell division." [CL:0000624, GOC:BHF] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation is_a: GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0035740 name: CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of a CD8-positive, alpha-beta T cell population by cell division." [CL:0000625, GOC:BHF] is_a: GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0035741 name: activated CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of an activated CD4-positive, alpha-beta T cell population by cell division." [CL:0000896, GOC:BHF] is_a: GO:0035739 ! CD4-positive, alpha-beta T cell proliferation [Term] id: GO:0035742 name: activated CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of an activated CD8-positive, alpha-beta T cell population by cell division." [CL:0000906, GOC:BHF] is_a: GO:0035740 ! CD8-positive, alpha-beta T cell proliferation [Term] id: GO:0035743 name: CD4-positive, alpha-beta T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell." [CL:0000624, GOC:BHF] is_a: GO:0002369 ! T cell cytokine production [Term] id: GO:0035744 name: T-helper 1 cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T-helper 1 cell." [CL:0000545, GOC:BHF] synonym: "Th1 cell cytokine production" EXACT [CL:0000545] is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production relationship: part_of GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0035745 name: T-helper 2 cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T-helper 2 cell." [CL:0000546, GOC:BHF] synonym: "Th2 cell cytokine production" EXACT [CL:0000546] is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production relationship: part_of GO:0042092 ! type 2 immune response [Term] id: GO:0035746 name: granzyme A production namespace: biological_process def: "The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0035747 name: natural killer cell chemotaxis namespace: biological_process def: "The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000623, GOC:BHF] is_a: GO:0048247 ! lymphocyte chemotaxis [Term] id: GO:0035748 name: myelin sheath abaxonal region namespace: cellular_component def: "The region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282] is_a: GO:0044464 ! cell part relationship: part_of GO:0043209 ! myelin sheath [Term] id: GO:0035749 name: myelin sheath adaxonal region namespace: cellular_component def: "The region of the myelin sheath nearest to the axon." [GOC:BHF, PMID:20237282] is_a: GO:0044464 ! cell part relationship: part_of GO:0043209 ! myelin sheath [Term] id: GO:0035750 name: protein localization to myelin sheath abaxonal region namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282] is_a: GO:0008105 ! asymmetric protein localization is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0035751 name: regulation of lysosomal lumen pH namespace: biological_process def: "Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:rph] is_a: GO:0051453 ! regulation of intracellular pH relationship: part_of GO:0007040 ! lysosome organization [Term] id: GO:0035752 name: lysosomal lumen pH elevation namespace: biological_process def: "Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:bf, GOC:rph] synonym: "lysosome pH elevation" EXACT [GOC:bf, GOC:rph] is_a: GO:0035751 ! regulation of lysosomal lumen pH is_a: GO:0051454 ! intracellular pH elevation [Term] id: GO:0035753 name: maintenance of DNA trinucleotide repeats namespace: biological_process def: "Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs." [GOC:rb, PMID:21347277, SO:0000291] is_a: GO:0043570 ! maintenance of DNA repeat elements [Term] id: GO:0035754 name: B cell chemotaxis namespace: biological_process def: "The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000236, GOC:BHF] is_a: GO:0048247 ! lymphocyte chemotaxis [Term] id: GO:0035755 name: cardiolipin hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol) to form phosphatidic acid (PA)." [CHEBI:28494, GOC:sp, PMID:17028579, PMID:21397848] is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0035756 name: transepithelial migration of symbiont in host namespace: biological_process def: "The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:10639460] synonym: "migration in host through an epithelial cell layer" EXACT [GOC:bf] synonym: "migration of symbiont within host by transepithelial trafficking" EXACT [GOC:bf] is_a: GO:0044001 ! migration in host [Term] id: GO:0035757 name: chemokine (C-C motif) ligand 19 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 19." [GOC:BHF] synonym: "CCL19 binding" EXACT [GOC:bf] is_a: GO:0019957 ! C-C chemokine binding [Term] id: GO:0035758 name: chemokine (C-C motif) ligand 21 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 21." [GOC:BHF] synonym: "CCL21 binding" EXACT [GOC:bf] is_a: GO:0019957 ! C-C chemokine binding [Term] id: GO:0035759 name: mesangial cell-matrix adhesion namespace: biological_process def: "The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney." [CL:0000650, GOC:BHF, PMID:15569314] is_a: GO:0007160 ! cell-matrix adhesion [Term] id: GO:0035760 name: cytoplasmic polyadenylation-dependent rRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate." [PMID:20368444] is_a: GO:0016075 ! rRNA catabolic process is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process [Term] id: GO:0035761 name: dorsal motor nucleus of vagus nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state." [GOC:dgh] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development [Term] id: GO:0035762 name: dorsal motor nucleus of vagus nerve morphogenesis namespace: biological_process def: "The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development [Term] id: GO:0035763 name: dorsal motor nucleus of vagus nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis [Term] id: GO:0035764 name: dorsal motor nucleus of vagus nerve formation namespace: biological_process def: "The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis [Term] id: GO:0035765 name: motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation namespace: biological_process def: "The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve." [GOC:dgh, PMID:21262462] is_a: GO:0021535 ! cell migration in hindbrain relationship: part_of GO:0035764 ! dorsal motor nucleus of vagus nerve formation [Term] id: GO:0035766 name: cell chemotaxis to fibroblast growth factor namespace: biological_process def: "The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF)." [GOC:BHF] is_a: GO:0044344 ! cellular response to fibroblast growth factor stimulus is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0035767 name: endothelial cell chemotaxis namespace: biological_process def: "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000115, GOC:BHF] is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0035768 name: endothelial cell chemotaxis to fibroblast growth factor namespace: biological_process def: "The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF)." [CL:0000115, GOC:BHF] is_a: GO:0035766 ! cell chemotaxis to fibroblast growth factor is_a: GO:0035767 ! endothelial cell chemotaxis [Term] id: GO:0035769 name: B cell chemotaxis across high endothelial venule namespace: biological_process def: "The movement of a B cell to cross a high endothelial venule in response to an external stimulus." [CL:0000236, GOC:BHF] synonym: "B-cell chemotaxis across high endothelial venule" EXACT [GOC:ebc] is_a: GO:0002518 ! lymphocyte chemotaxis across high endothelial venule is_a: GO:0035754 ! B cell chemotaxis [Term] id: GO:0035770 name: RNA granule namespace: cellular_component def: "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:sp, PMID:16520386, PMID:21436445] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0035771 name: interleukin-4-mediated signaling pathway namespace: biological_process def: "A series of molecular events generated as a consequence of interleukin-4 binding to a cell surface receptor." [GOC:BHF] synonym: "IL-4-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-4-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway is_a: GO:0071353 ! cellular response to interleukin-4 [Term] id: GO:0035772 name: interleukin-13-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of interleukin-13 binding to a cell surface receptor." [GOC:BHF] synonym: "IL-13-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-13-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0035773 name: insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus." [GOC:bf, GOC:yaf, PMID:8492079] synonym: "insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] is_a: GO:0030073 ! insulin secretion relationship: part_of GO:0071333 ! cellular response to glucose stimulus [Term] id: GO:0035774 name: positive regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:bf, GOC:yaf] synonym: "positive regulation of insulin secretion in response to glucose" EXACT [GOC:bf] is_a: GO:0032024 ! positive regulation of insulin secretion is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus relationship: positively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus [Term] id: GO:0035775 name: pronephric glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:yaf, PMID:18787069] comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. is_a: GO:0072102 ! glomerulus morphogenesis relationship: part_of GO:0039021 ! pronephric glomerulus development [Term] id: GO:0035776 name: pronephric proximal tubule development namespace: biological_process def: "The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:yaf, PMID:18787069] is_a: GO:0039020 ! pronephric nephron tubule development is_a: GO:0072014 ! proximal tubule development [Term] id: GO:0035777 name: pronephric distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:yaf, PMID:18787069] is_a: GO:0039020 ! pronephric nephron tubule development is_a: GO:0072017 ! distal tubule development [Term] id: GO:0035778 name: pronephric nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state." [GOC:yaf, PMID:18787069] is_a: GO:0039014 ! cell differentiation involved in pronephros development is_a: GO:0072160 ! nephron tubule epithelial cell differentiation relationship: part_of GO:0039020 ! pronephric nephron tubule development [Term] id: GO:0035779 name: angioblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf] synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0035780 name: CD80 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival." [GOC:BHF, GOC:ebc] synonym: "CD80 anabolism" EXACT [GOC:bf] synonym: "CD80 biosynthesis" EXACT [GOC:bf] synonym: "CD80 formation" EXACT [GOC:bf] synonym: "CD80 synthesis" EXACT [GOC:bf] is_a: GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0035781 name: CD86 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival." [GOC:BHF, GOC:ebc] synonym: "CD86 anabolism" EXACT [GOC:bf] synonym: "CD86 biosynthesis" EXACT [GOC:bf] synonym: "CD86 formation" EXACT [GOC:bf] synonym: "CD86 synthesis" EXACT [GOC:bf] is_a: GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0035782 name: mature natural killer cell chemotaxis namespace: biological_process def: "The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules." [CL:0000824, GOC:BHF] synonym: "activated natural killer cell chemotaxis" EXACT [GOC:ebc] is_a: GO:0035747 ! natural killer cell chemotaxis [Term] id: GO:0035783 name: CD4-positive, alpha beta T cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha beta T cell activation." [CL:0000624, GOC:BHF] is_a: GO:0031295 ! T cell costimulation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation [Term] id: GO:0035784 name: nickel ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of nickel ions within an organism or cell." [GOC:kmv] synonym: "nickel homeostasis" EXACT [GOC:bf] is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0035785 name: cellular nickel ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of nickel ions at the level of a cell." [GOC:kmv] synonym: "cellular nickel homeostasis" EXACT [GOC:bf] is_a: GO:0035784 ! nickel ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0035786 name: protein complex oligomerization namespace: biological_process def: "The association of two or more multisubunit protein complexes to form dimers or other multimers of a protein complex." [GOC:bf, GOC:mcc, PMID:18293929] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0035787 name: cell migration involved in kidney development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ." [GOC:bf, GOC:yaf] is_a: GO:0016477 ! cell migration relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0035788 name: cell migration involved in metanephros development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ." [GOC:bf, GOC:yaf] synonym: "cell migration involved in metanephric kidney development" EXACT [GOC:bf] is_a: GO:0035787 ! cell migration involved in kidney development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0035789 name: metanephric mesenchymal cell migration namespace: biological_process def: "The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros." [GOC:bf, GOC:yaf, PMID:10734101, PMID:19019919] synonym: "metanephric mesenchyme chemotaxis" NARROW [PMID:19019919] is_a: GO:0035788 ! cell migration involved in metanephros development [Term] id: GO:0035790 name: platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-alpha binding to one of its physiological ligands." [GOC:bf, PMID:10372961] synonym: "alphaPDGF receptor signaling pathway" EXACT [PMID:10372961] synonym: "PDGF receptor-alpha signaling pathway" EXACT [GOC:bf] synonym: "PDGFR-alpha signaling pathway" RELATED [GOC:bf] is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0035791 name: platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands." [GOC:bf, PMID:10372961] synonym: "betaPDGF receptor signaling pathway" EXACT [PMID:10372961] synonym: "PDGF receptor-beta signaling pathway" EXACT [GOC:bf] synonym: "PDGFR-beta signaling pathway" EXACT [GOC:bf] is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0035792 name: other organism postsynaptic membrane namespace: cellular_component def: "A postsynaptic membrane that is part of another organism, i.e. a secondary organism with which the first organism is interacting. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane." [GOC:ecd] is_a: GO:0044218 ! other organism cell membrane [Term] id: GO:0035793 name: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration as a result of the series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands." [GOC:bf, GOC:yaf, PMID:10734101] synonym: "positive regulation of metanephric mesenchymal cell migration by betaPDGF receptor signaling pathway" EXACT [PMID:10734101] synonym: "positive regulation of metanephric mesenchymal cell migration by PDGF receptor-beta signaling pathway" EXACT [GOC:bf] synonym: "positive regulation of metanephric mesenchymal cell migration by PDGFR-beta signaling pathway" EXACT [GOC:bf] is_a: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway is_a: GO:2000591 ! positive regulation of metanephric mesenchymal cell migration [Term] id: GO:0035794 name: positive regulation of mitochondrial membrane permeability namespace: biological_process def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf, PMID:12546810] synonym: "mitochondrial membrane permeability transition" NARROW [PMID:17136322] synonym: "mitochondrial membrane permeabilization" NARROW [PMID:12546810] synonym: "mitochondrial permeability transition" NARROW [PMID:21424245] synonym: "positive regulation of transport across mitochondrial membrane" EXACT [GOC:bf] is_a: GO:0046902 ! regulation of mitochondrial membrane permeability [Term] id: GO:0035795 name: negative regulation of mitochondrial membrane permeability namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [PMID:10781072] synonym: "mitochondrial membrane impermeability" RELATED [PMID:10781072] synonym: "mitochondrial membrane impermeabilization" NARROW [GOC:bf] synonym: "negative regulation of transport across mitochondrial membrane" EXACT [GOC:bf] is_a: GO:0046902 ! regulation of mitochondrial membrane permeability [Term] id: GO:0035796 name: ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing namespace: cellular_component def: "A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [PMID:18931129, PMID:20972419, PMID:21135102] comment: The ECF-type transporters differs from other types of ABC transporters because the substrate-binding subunit lies integral to the membrane. synonym: "ATP-binding cassette (ABC) transporter complex, ECF-type" EXACT [GOC:bf] synonym: "energy coupling factor (ECF)-type ABC transporter" EXACT [PMID:21135102] synonym: "energy-coupling factor transporter" EXACT [PMID:18931129] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex [Term] id: GO:0035797 name: tellurite methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride)." [CHEBI:30477, GOC:bf, GOC:kad, PMID:11053398, PMID:21244361] synonym: "S-adenosyl-L-methionine-dependent tellurite methyltransferase activity" EXACT [GOC:bf] synonym: "SAM-dependent tellurite methyltransferase activity" EXACT [GOC:bf] synonym: "tellurite methylase activity" BROAD [GOC:bf] is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0035798 name: 2-alkenal reductase activity (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+." [GOC:bf, GOC:kad, PMID:16299173] synonym: "NADPH:2-alkenal alpha,beta-hydrogenase activity" EXACT [GOC:bf, GOC:kad] is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0035799 name: ureter maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:bf, GOC:yaf, PMID:17881463] is_a: GO:0048799 ! organ maturation relationship: part_of GO:0072189 ! ureter development [Term] id: GO:0035800 name: ubiquitin-specific protease activator activity namespace: molecular_function def: "Increases the activity of a ubiquitin-specific protease, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences." [GOC:sart, ISBN:0120793709] is_a: GO:0016504 ! peptidase activator activity [Term] id: GO:0035801 name: adrenal cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens)." [http://en.wikipedia.org/wiki/Adrenal_cortex, PMID:12185666, PMID:21115154] synonym: "adrenal gland cortex development" EXACT [MA:0000118] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030325 ! adrenal gland development [Term] id: GO:0035802 name: adrenal cortex formation namespace: biological_process def: "The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate)." [PMID:12185666, PMID:21115154] synonym: "adrenal gland cortex formation" EXACT [MA:0000118] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035801 ! adrenal cortex development [Term] id: GO:0035803 name: egg coat formation namespace: biological_process def: "Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [GOC:bf, GOC:sart, PMID:16944418, PMID:17163408] synonym: "VE formation" NARROW [PMID:16944418, PMID:17163408] synonym: "vitelline envelope formation" NARROW [PMID:16944418] synonym: "zona pellucida assembly" NARROW [GOC:yaf, PMID:18420282] synonym: "ZP assembly" NARROW [PMID:18420282] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0035804 name: structural constituent of egg coat namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408] synonym: "structural constituent of vitelline envelope" NARROW [PMID:16944418, PMID:17163408] synonym: "structural constituent of zona pellucida" NARROW [PMID:16944418, PMID:17163408] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0035805 name: egg coat namespace: cellular_component def: "A specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408] synonym: "vitelline membrane" NARROW [PMID:16944418, PMID:17163408] synonym: "zona pellucida" NARROW [PMID:16944418, PMID:17163408] is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0035806 name: modulation by organism of blood coagulation in other organism namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf] synonym: "modulation by organism of blood clotting in other organism" EXACT [GOC:bf] synonym: "modulation of blood coagulation in other organism" EXACT [GOC:bf] synonym: "regulation by organism of blood clotting in other organism" EXACT [GOC:bf] synonym: "regulation of blood clotting in other organism" EXACT [GOC:bf] synonym: "regulation of blood coagulation in other organism" EXACT [GOC:bf] is_a: GO:0035821 ! modification of morphology or physiology of other organism [Term] id: GO:0035807 name: positive regulation by organism of blood coagulation in other organism namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf, PMID:12362232] synonym: "positive regulation by organism of blood clotting in other organism" EXACT [GOC:bf] synonym: "positive regulation of blood clotting in other organism" EXACT [GOC:bf] synonym: "positive regulation of blood coagulation in other organism" EXACT [GOC:bf] is_a: GO:0035806 ! modulation by organism of blood coagulation in other organism [Term] id: GO:0035808 name: meiotic recombination initiation complex namespace: cellular_component def: "A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins." [GOC:vw, PMID:12897161, PMID:20364342, PMID:21429938] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0035809 name: regulation of urine volume namespace: biological_process def: "Any process that modulates the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11] synonym: "regulation of urinary volume" EXACT [] synonym: "regulation of urine flow" EXACT [] is_a: GO:0003014 ! renal system process is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0035810 name: positive regulation of urine volume namespace: biological_process def: "Any process that increases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11] synonym: "diuresis" BROAD [GOC:mtg_25march11] synonym: "elevation of urinary volume" EXACT [GOC:mtg_25march11] synonym: "increase in urine flow" EXACT [GOC:mtg_25march11] is_a: GO:0035809 ! regulation of urine volume [Term] id: GO:0035811 name: negative regulation of urine volume namespace: biological_process def: "Any process that decreases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11] synonym: "antidiuresis" BROAD [GOC:mtg_25march11] synonym: "decrease in urine flow" EXACT [GOC:mtg_25march11] synonym: "reduction of urinary volume" EXACT [GOC:mtg_25march11] is_a: GO:0035809 ! regulation of urine volume [Term] id: GO:0035812 name: renal sodium excretion namespace: biological_process def: "The elimination by an organism of sodium in the urine." [GOC:mtg_25march11] is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion relationship: part_of GO:0055078 ! sodium ion homeostasis [Term] id: GO:0035813 name: regulation of renal sodium excretion namespace: biological_process def: "Any process that modulates the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11] is_a: GO:0044062 ! regulation of excretion is_a: GO:2000021 ! regulation of ion homeostasis relationship: regulates GO:0035812 ! renal sodium excretion [Term] id: GO:0035814 name: negative regulation of renal sodium excretion namespace: biological_process def: "Any process that decreases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11] comment: The amount of sodium excreted in urine over a unit of time can be decreased by decreasing the volume of urine produced (antidiuresis) and/or by decreasing the concentration of sodium in the urine. is_a: GO:0035813 ! regulation of renal sodium excretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0035812 ! renal sodium excretion [Term] id: GO:0035815 name: positive regulation of renal sodium excretion namespace: biological_process def: "Any process that increases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11] comment: The amount of sodium excreted in urine over a unit of time can be increased by increasing the volume of urine produced (diuresis) and/or by increasing the concentration of sodium in the urine. synonym: "natriuresis" BROAD [GOC:mtg_25march11] is_a: GO:0035813 ! regulation of renal sodium excretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0035812 ! renal sodium excretion [Term] id: GO:0035816 name: renal water absorption involved in negative regulation of urine volume namespace: biological_process def: "Any process where water is taken up from the collecting ducts and proximal and distal loops of the nephron, which acts to decrease the amount of urine that is excreted from the body per unit time." [GOC:mtg_25march11] is_a: GO:0070295 ! renal water absorption relationship: part_of GO:0035811 ! negative regulation of urine volume [Term] id: GO:0035817 name: renal sodium ion absorption involved in negative regulation of renal sodium excretion namespace: biological_process def: "Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time." [GOC:mtg_25march11] is_a: GO:0070294 ! renal sodium ion absorption relationship: part_of GO:0035814 ! negative regulation of renal sodium excretion [Term] id: GO:0035818 name: positive regulation of urine volume by pressure natriuresis namespace: biological_process def: "An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11] synonym: "diuresis resulting from pressure natriuresis" RELATED [GOC:mtg_25march11] is_a: GO:0003095 ! pressure natriuresis is_a: GO:0035810 ! positive regulation of urine volume [Term] id: GO:0035819 name: positive regulation of renal sodium excretion by pressure natriuresis namespace: biological_process def: "An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11] synonym: "natriuresis resulting from pressure natriuresis" RELATED [] is_a: GO:0003095 ! pressure natriuresis is_a: GO:0035815 ! positive regulation of renal sodium excretion [Term] id: GO:0035820 name: negative regulation of renal sodium excretion by angiotensin namespace: biological_process def: "The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time." [GOC:mtg_25march11] is_a: GO:0003083 ! negative regulation of renal output by angiotensin is_a: GO:0035814 ! negative regulation of renal sodium excretion [Term] id: GO:0035821 name: modification of morphology or physiology of other organism namespace: biological_process def: "The process in which an organism effects a change in the structure or processes of a second organism." [GOC:bf] synonym: "regulation of morphology of other organism " NARROW [GOC:bf] synonym: "regulation of morphology or physiology of other organism" RELATED [GOC:bf] synonym: "regulation of physiological process of other organism " NARROW [GOC:bf] synonym: "regulation of physiology of other organism" NARROW [GOC:bf] is_a: GO:0044419 ! interspecies interaction between organisms is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0035822 name: gene conversion namespace: biological_process def: "A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor." [GOC:mah, PMID:17846636] is_a: GO:0006310 ! DNA recombination [Term] id: GO:0035823 name: short tract gene conversion namespace: biological_process def: "A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385] is_a: GO:0035822 ! gene conversion [Term] id: GO:0035824 name: long tract gene conversion namespace: biological_process def: "A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385] is_a: GO:0035822 ! gene conversion [Term] id: GO:0035825 name: reciprocal DNA recombination namespace: biological_process def: "A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215] synonym: "chromosomal crossover" EXACT [GOC:mah, Wikipedia:Chromosomal_crossover] xref: Wikipedia:Chromosomal_crossover is_a: GO:0006310 ! DNA recombination [Term] id: GO:0035826 name: rubidium ion transport namespace: biological_process def: "The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:49847, GOC:yaf] synonym: "Rb+ transport" EXACT [CHEBI:49847] synonym: "rubidium cation transport" EXACT [CHEBI:49847] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0035827 name: rubidium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of rubidium ions (Rb+) from one side of a membrane to the other." [CHEBI:49847, GOC:yaf] synonym: "Rb+ transmembrane transporter activity" EXACT [CHEBI:49847] synonym: "rubidium cation transmembrane transporter activity" EXACT [CHEBI:49847] synonym: "rubidium transmembrane transporter activity" RELATED [GOC:bf] is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0035828 name: renal rubidium ion transport namespace: biological_process def: "The directed movement of rubidium ions (Rb+) by the kidney." [CHEBI:49847, GOC:yaf] synonym: "renal Rb+ transport" EXACT [CHEBI:49847] synonym: "renal rubidium cation transport" EXACT [CHEBI:49847] is_a: GO:0003014 ! renal system process is_a: GO:0035826 ! rubidium ion transport [Term] id: GO:0035829 name: renal rubidium ion absorption namespace: biological_process def: "A renal system process in which rubidium ions are taken up from the collecting ducts and proximal and distal loops of the nephron." [CHEBI:49847, GOC:yaf] synonym: "renal Rb+ absorption" EXACT [CHEBI:49847] synonym: "renal rubidium cation absorption" EXACT [CHEBI:49847] is_a: GO:0035828 ! renal rubidium ion transport is_a: GO:0070293 ! renal absorption [Term] id: GO:0035830 name: palmatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving palmatine, a berberine alkaloid found in many plants." [CHEBI:16096, GOC:yaf] synonym: "palmatine metabolism" EXACT [GOC:bf] is_a: GO:0033076 ! isoquinoline alkaloid metabolic process [Term] id: GO:0035831 name: palmatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of palmatine, a berberine alkaloid found in many plants." [CHEBI:16096, GOC:yaf] synonym: "palmatine anabolism" EXACT [GOC:bf] synonym: "palmatine biosynthesis" EXACT [GOC:bf] synonym: "palmatine formation" EXACT [GOC:bf] synonym: "palmatine synthesis" EXACT [GOC:bf] is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process is_a: GO:0035830 ! palmatine metabolic process [Term] id: GO:0035832 name: berbamunine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving berbamunine, an isoquinoline alkaloid." [CHEBI:16777, GOC:yaf] synonym: "berbamunine metabolism" EXACT [GOC:bf] is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process [Term] id: GO:0035833 name: berbamunine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid." [CHEBI:16777, GOC:yaf] synonym: "berbamunine anabolism" EXACT [GOC:bf] synonym: "berbamunine biosynthesis" EXACT [GOC:bf] synonym: "berbamunine formation" EXACT [GOC:bf] synonym: "berbamunine synthesis" EXACT [GOC:bf] is_a: GO:0009708 ! benzyl isoquinoline alkaloid biosynthetic process is_a: GO:0035832 ! berbamunine metabolic process [Term] id: GO:0035834 name: indole alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton." [CHEBI:38958, GOC:yaf] synonym: "indole alkaloid metabolism" EXACT [GOC:bf] is_a: GO:0009820 ! alkaloid metabolic process [Term] id: GO:0035835 name: indole alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton." [CHEBI:38958, GOC:yaf] synonym: "indole alkaloid anabolism" EXACT [GOC:bf] synonym: "indole alkaloid biosynthesis" EXACT [GOC:bf] synonym: "indole alkaloid formation" EXACT [GOC:bf] synonym: "indole alkaloid synthesis" EXACT [GOC:bf] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0035834 ! indole alkaloid metabolic process [Term] id: GO:0035836 name: ergot alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an ergot alkaloid, an indole alkaloid." [CHEBI:23943, GOC:yaf] synonym: "ergot alkaloid metabolism" EXACT [GOC:bf] is_a: GO:0035834 ! indole alkaloid metabolic process [Term] id: GO:0035837 name: ergot alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an ergot alkaloid." [CHEBI:23943, GOC:yaf] synonym: "ergot alkaloid anabolism" EXACT [GOC:bf] synonym: "ergot alkaloid biosynthesis" EXACT [GOC:bf] synonym: "ergot alkaloid formation" EXACT [GOC:bf] synonym: "ergot alkaloid synthesis" EXACT [GOC:bf] is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:0035836 ! ergot alkaloid metabolic process [Term] id: GO:0035838 name: growing cell tip namespace: cellular_component def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs." [GOC:mah] synonym: "growing cell end" EXACT [GOC:mah] is_a: GO:0030427 ! site of polarized growth is_a: GO:0051286 ! cell tip [Term] id: GO:0035839 name: non-growing cell tip namespace: cellular_component def: "A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures." [GOC:expert_jd, GOC:mah] synonym: "new cell end" RELATED [GOC:mah] synonym: "non-growing cell end" EXACT [GOC:mah] is_a: GO:0051286 ! cell tip [Term] id: GO:0035840 name: old growing cell tip namespace: cellular_component def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah] synonym: "old growing cell end" EXACT [GOC:mah] is_a: GO:0035838 ! growing cell tip [Term] id: GO:0035841 name: new growing cell tip namespace: cellular_component def: "A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth." [GOC:expert_jd, GOC:mah, PMID:19431238] synonym: "new cell tip after activation of bipolar cell growth" EXACT [GOC:bf] synonym: "post-NETO new cell end" EXACT [GOC:mah] synonym: "post-NETO new cell tip" EXACT [GOC:mah] synonym: "post-new end take-off new cell tip" EXACT [GOC:mah] is_a: GO:0035838 ! growing cell tip [Term] id: GO:0035842 name: old cell tip after activation of bipolar cell growth namespace: cellular_component def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah] synonym: "post-NETO old cell end" EXACT [GOC:mah] synonym: "post-NETO old cell tip" EXACT [GOC:mah] synonym: "post-new end take-off old cell tip" EXACT [GOC:mah] is_a: GO:0035840 ! old growing cell tip [Term] id: GO:0035843 name: endonuclear canal namespace: cellular_component def: "A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope." [GOC:bf, PMID:18359585] is_a: GO:0044428 ! nuclear part relationship: part_of GO:0001673 ! male germ cell nucleus [Term] id: GO:0035844 name: cloaca development namespace: biological_process def: "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates." [GOC:dgh, ISBN:0582227089] synonym: "cloacal development" EXACT [GOC:bf] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001655 ! urogenital system development relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0035845 name: photoreceptor cell outer segment organization namespace: biological_process def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials." [ISBN:0824072820, PMID:14507858] synonym: "photoreceptor outer segment organization" EXACT [GOC:bf] is_a: GO:0071842 ! cellular component organization at cellular level relationship: part_of GO:0042461 ! photoreceptor cell development [Term] id: GO:0035846 name: oviduct epithelium development namespace: biological_process def: "The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct." [GOC:yaf, http://www.thefreedictionary.com/oviduct] synonym: "fallopian tube epithelium development" NARROW [GOC:yaf] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060429 ! epithelium development relationship: part_of GO:0060066 ! oviduct development [Term] id: GO:0035847 name: uterine epithelium development namespace: biological_process def: "The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:bf, GOC:yaf] synonym: "uterus epithelial development" EXACT [GOC:yaf] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060429 ! epithelium development relationship: part_of GO:0060065 ! uterus development [Term] id: GO:0035848 name: oviduct morphogenesis namespace: biological_process def: "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, http://www.thefreedictionary.com/oviduct] synonym: "fallopian tube morphogenesis" NARROW [GOC:yaf] is_a: GO:0009887 ! organ morphogenesis is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0060066 ! oviduct development [Term] id: GO:0035849 name: nephric duct elongation namespace: biological_process def: "The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney." [GOC:yaf, PMID:16216236] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0072178 ! nephric duct morphogenesis [Term] id: GO:0035850 name: epithelial cell differentiation involved in kidney development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:yaf, PMID:16216236] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0035851 name: Krueppel-associated box domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors." [InterPro:IPR001909] synonym: "KRAB domain binding" EXACT [InterPro:IPR001909] synonym: "Krueppel-associated box binding" EXACT [InterPro:IPR001909] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0035852 name: horizontal cell localization namespace: biological_process def: "Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina." [CL:0000745, GOC:bf, GOC:yaf, PMID:18094249] synonym: "horizontal cell positioning" EXACT [PMID:18094249] synonym: "laminar positioning of retinal horizontal cell" EXACT [PMID:18094249] synonym: "retinal horizontal cell positioning" EXACT [PMID:18094249] is_a: GO:0051674 ! localization of cell relationship: part_of GO:0010842 ! retina layer formation [Term] id: GO:0035853 name: chromosome passenger complex localization to spindle midzone namespace: biological_process def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:mah, GOC:vw, PMID:15296749] synonym: "chromosomal passenger complex localization to spindle midzone" EXACT [GOC:bf] synonym: "chromosome passenger complex localisation to spindle midzone" EXACT [GOC:bf] synonym: "chromosome passenger complex localization to central spindle" EXACT [PMID:14528012] synonym: "chromosome passenger complex localization to spindle equator" EXACT [GOC:bf] synonym: "CPC complex localization to spindle midzone" EXACT [GOC:bf] synonym: "CPC localization to spindle midzone" EXACT [GOC:bf] is_a: GO:0033365 ! protein localization to organelle is_a: GO:0034629 ! cellular protein complex localization [Term] id: GO:0035854 name: eosinophil fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin." [CL:0000771, GOC:BHF, GOC:vk] synonym: "eosinophil cell fate commitment" EXACT [GOC:bf] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030222 ! eosinophil differentiation [Term] id: GO:0035855 name: megakaryocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk] synonym: "megakaryocyte cell development" EXACT [GOC:bf] is_a: GO:0048468 ! cell development relationship: part_of GO:0030219 ! megakaryocyte differentiation [Term] id: GO:0035856 name: eosinophil development namespace: biological_process def: "The process whose specific outcome is the progression of an eosinophil cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a eosinophil cell fate." [CL:0000771, GOC:BHF, GOC:vk] synonym: "eosinophil cell development" EXACT [GOC:bf] is_a: GO:0048468 ! cell development relationship: part_of GO:0030222 ! eosinophil differentiation [Term] id: GO:0035857 name: eosinophil fate specification namespace: biological_process def: "The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [CL:0000771, GOC:BHF, GOC:vk] synonym: "eosinophil cell fate specification" EXACT [GOC:bf] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0035854 ! eosinophil fate commitment [Term] id: GO:0035858 name: eosinophil fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000771, GOC:BHF, GOC:vk] synonym: "eosinophil cell fate determination" EXACT [GOC:bf] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0035854 ! eosinophil fate commitment [Term] id: GO:0035859 name: Seh1-associated complex namespace: cellular_component def: "A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883] synonym: "SEA complex" EXACT [GOC:jh, PMID:21454883] is_a: GO:0043234 ! protein complex [Term] id: GO:0035860 name: glial cell-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:yaf, PMID:12953054] synonym: "GDNF receptor signaling pathway" EXACT [GOC:yaf] synonym: "glial cell derived neurotrophic factor receptor signaling pathway" EXACT [GOC:bf] synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:yaf] synonym: "glial cell-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0035861 name: site of double-strand break namespace: cellular_component def: "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] synonym: "DNA damage foci" RELATED [GOC:vw] synonym: "DNA damage focus" RELATED [GOC:mah, PMID:20096808, PMID:21035408] synonym: "ionizing radiation-induced foci" RELATED [PMID:20096808, PMID:21035408] synonym: "IRIF" RELATED [PMID:20096808, PMID:21035408] synonym: "site of DSB" EXACT [PMID:21035408] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0035862 name: dITP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [CHEBI:28807, GOC:bf] synonym: "2'-Deoxyinosine 5'-triphosphate metabolic process" EXACT [CHEBI:28807] synonym: "2'-Deoxyinosine-5'-triphosphate metabolic process" EXACT [CHEBI:28807] synonym: "deoxyinosine 5'-triphosphate metabolic process" EXACT [CHEBI:28807] synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) metabolic process" EXACT [GOC:dgf] synonym: "dITP metabolism" EXACT [GOC:bf] is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0035863 name: dITP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [CHEBI:28807, GOC:dgf] synonym: "2'-Deoxyinosine 5'-triphosphate catabolic process" EXACT [CHEBI:28807] synonym: "2'-Deoxyinosine-5'-triphosphate catabolic process" EXACT [CHEBI:28807] synonym: "deoxyinosine 5'-triphosphate catabolic process" EXACT [CHEBI:28807] synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) catabolic process" EXACT [GOC:dgf] synonym: "dITP breakdown" EXACT [GOC:bf] synonym: "dITP catabolism" EXACT [GOC:bf] synonym: "dITP degradation" EXACT [GOC:bf] is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process is_a: GO:0035862 ! dITP metabolic process [Term] id: GO:0035864 name: response to potassium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf] synonym: "response to K+ ion" EXACT [GOC:bf] synonym: "response to potassium" EXACT [GOC:bf] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0035865 name: cellular response to potassium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf] synonym: "cellular response to K+ ion" EXACT [GOC:bf] synonym: "cellular response to potassium" EXACT [GOC:bf] is_a: GO:0035864 ! response to potassium ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0035866 name: alphav-beta3 integrin-PKCalpha complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha." [GOC:BHF, GOC:ebc, PMID:16014375] synonym: "alphav-beta3 integrin-PKCa complex" EXACT [GOC:ebc] synonym: "alphav-beta3 integrin-protein kinase C alpha complex" EXACT [GOC:bf] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0035867 name: alphav-beta3 integrin-IGF-1-IGF1R complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits." [GOC:BHF, GOC:ebc, PMID:19578119] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0035868 name: alphav-beta3 integrin-HMGB1 complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein." [GOC:BHF, GOC:ebc, PMID:20826760] synonym: "alphav-beta3 integrin-high mobility group box 1 complex" EXACT [GOC:bf] synonym: "alphaV-beta3 integrin-HMGB1 complex" EXACT [GOC:ebc] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0035869 name: ciliary transition zone namespace: cellular_component def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition." [GOC:kmv, PMID:21422230] is_a: GO:0044441 ! cilium part relationship: part_of GO:0031513 ! nonmotile primary cilium [Term] id: GO:0035870 name: dITP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dITP + H2O = dIMP + diphosphate." [EC:3.6.1.-, GOC:dgf, PMID:21548881, RHEA:28342] synonym: "2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase activity" EXACT [KEGG:R03531] synonym: "deoxyinosine triphosphate pyrophosphatase activity" EXACT [GOC:bf] synonym: "dITP pyrophosphatase activity" EXACT [GOC:bf] xref: EC:3.6.1.- xref: KEGG:R03531 xref: MetaCyc:RXN0-1602 xref: RHEA:28342 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0035871 name: protein K11-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein." [GOC:sp, PMID:21596315] synonym: "protein K11-linked deubiquitinylation" EXACT [GOC:bf] synonym: "protein K11-linked deubiquitylation" EXACT [GOC:bf] is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0035872 name: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process." [GOC:sj, PMID:18280719, Reactome:168643] synonym: "NLR signaling pathway" EXACT [PMID:18280719] synonym: "NOD-like receptor signaling pathway" RELATED [Wikipedia:NOD-like_receptor] synonym: "nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway" EXACT [PMID:18280719] synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction" EXACT [GOC:bf] synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway" EXACT [GOC:bf] synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0035873 name: lactate transmembrane transport namespace: biological_process def: "The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:mcc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015727 ! lactate transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0035874 name: cellular response to copper ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions." [GOC:vw, PMID:16467469] synonym: "cellular response to copper starvation" EXACT [GOC:bf] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0035875 name: maintenance of meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436] synonym: "maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf] synonym: "maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:bf] synonym: "maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:bf] is_a: GO:0034090 ! maintenance of meiotic sister chromatid cohesion relationship: part_of GO:0051754 ! meiotic sister chromatid cohesion, centromeric [Term] id: GO:0035876 name: maintenance of meiotic sister chromatid cohesion, arms namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436] synonym: "maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:bf] synonym: "maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:bf] is_a: GO:0034090 ! maintenance of meiotic sister chromatid cohesion relationship: part_of GO:0051760 ! meiotic sister chromatid cohesion, arms [Term] id: GO:0035877 name: death effector domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD)." [GOC:ecd, InterPro:IPR001875] comment: For binding to the death domain, consider instead the term 'death domain binding ; GO:0070513'. synonym: "DED binding" EXACT [InterPro:IPR001875] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0035878 name: nail development namespace: biological_process def: "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it." [GOC:bf, http://en.wikipedia.org/wiki/Nail_(anatomy), ISBN:0323025781, UBERON:0001705] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060173 ! limb development [Term] id: GO:0035879 name: plasma membrane lactate transport namespace: biological_process def: "The directed movement of lactate across a plasma membrane." [GOC:mcc] synonym: "lactate plasma membrane transport" EXACT [GOC:bf] is_a: GO:0035873 ! lactate transmembrane transport [Term] id: GO:0035880 name: embryonic nail plate morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits." [GOC:BHF, GOC:vk, http://en.wikipedia.org/wiki/Nail_(anatomy), ISBN:0323025781, PMID:11369996, UBERON:0008198] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0035878 ! nail development relationship: part_of GO:0042733 ! embryonic digit morphogenesis [Term] id: GO:0035881 name: amacrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons." [CL:0000561, GOC:bf] synonym: "amacrine neuron differentiation" EXACT [CL:0000561] is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0003407 ! neural retina development [Term] id: GO:0035882 name: defecation rhythm namespace: biological_process def: "The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated." [GOC:bf, GOC:kmv, PMID:7479775, PMID:8158250, PMID:9066270] synonym: "defecation behavior" RELATED [PMID:7479775, PMID:9066270] synonym: "defecation cycle" EXACT [PMID:8158250] synonym: "defecation motor program" EXACT [GOC:kmv, PMID:9066270] synonym: "DMP" EXACT [PMID:9066270] is_a: GO:0007624 ! ultradian rhythm relationship: part_of GO:0030421 ! defecation [Term] id: GO:0035883 name: enteroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0035884 name: arabinan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arabinan, a branched homopolymer of L-arabinose." [CHEBI:22590, GOC:rs, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0031221 ! arabinan metabolic process [Term] id: GO:0035885 name: exochitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293, PMID:16298970, PMID:21390509] is_a: GO:0004568 ! chitinase activity [Term] id: GO:0035886 name: vascular smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954] synonym: "vascular associated smooth muscle cell differentiation" EXACT [CL:0000359] synonym: "VSMC differentiation" EXACT [PMID:16151017] is_a: GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0035887 name: aortic smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl] is_a: GO:0035886 ! vascular smooth muscle cell differentiation [Term] id: GO:0038001 name: paracrine signaling namespace: biological_process def: "The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other." [GOC:mtg_signaling_feb11, ISBN:3527303782] comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from endocrine signaling. synonym: "paracrine signalling" EXACT [GOC:bf] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0038002 name: endocrine signaling namespace: biological_process def: "The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other." [GOC:mtg_signaling_feb11, ISBN:0199264678, ISBN:3527303782] comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from paracrine signaling. synonym: "endocrine signalling" EXACT [GOC:bf] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0050886 ! endocrine process [Term] id: GO:0038003 name: opioid receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an opioid receptor binding to one of its physiological ligands." [GOC:bf, PMID:20494127] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0038004 name: epidermal growth factor receptor ligand maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor." [GOC:signaling, PMID:11672524] synonym: "EGFR ligand maturation" EXACT [GOC:bf] is_a: GO:0035638 ! signal maturation is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway is_a: GO:0051604 ! protein maturation [Term] id: GO:0038005 name: peptide bond cleavage involved in epidermal growth factor receptor ligand maturation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a ligand for the epidermal growth factor receptor, as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. In Drosophila for example, in the Golgi apparatus of the signal producing cell, Spitz is cleaved within its transmembrane domain to release a functional soluble extracellular fragment." [GOC:signaling, PMID:11672524, PMID:11672525] synonym: "EGFR ligand maturation by peptide bond cleavage" EXACT [GOC:bf] synonym: "EGFR ligand processing" EXACT [GOC:bf] synonym: "epidermal growth factor receptor ligand processing" EXACT [GOC:bf] synonym: "peptide bond cleavage involved in EGFR ligand maturation" EXACT [GOC:bf] is_a: GO:0051605 ! protein maturation by peptide bond cleavage relationship: part_of GO:0038004 ! epidermal growth factor receptor ligand maturation [Term] id: GO:0039003 name: pronephric field specification namespace: biological_process def: "The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney field specification" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072004 ! kidney field specification relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039004 name: specification of pronephric proximal tubule identity namespace: biological_process def: "The process in which the proximal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0039005 ! specification of pronephric tubule identity is_a: GO:0072082 ! specification of proximal tubule identity is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development relationship: part_of GO:0039011 ! pronephric proximal tubule morphogenesis [Term] id: GO:0039005 name: specification of pronephric tubule identity namespace: biological_process def: "The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0039017 ! pattern specification involved in pronephros development is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis [Term] id: GO:0039006 name: pronephric nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros." [GOC:mtg_kidney_jan10] synonym: "pronephric tubule formation" EXACT [GOC:mtg_kidney_jan10] synonym: "pronephros tubule formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072079 ! nephron tubule formation relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis relationship: part_of GO:0072116 ! pronephros formation [Term] id: GO:0039007 name: pronephric nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10] is_a: GO:0072028 ! nephron morphogenesis relationship: part_of GO:0039019 ! pronephric nephron development relationship: part_of GO:0072114 ! pronephros morphogenesis [Term] id: GO:0039008 name: pronephric nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron." [GOC:mtg_kidney_jan10, ZFA:00001558] is_a: GO:0072078 ! nephron tubule morphogenesis relationship: part_of GO:0039007 ! pronephric nephron morphogenesis relationship: part_of GO:0039020 ! pronephric nephron tubule development [Term] id: GO:0039009 name: rectal diverticulum development namespace: biological_process def: "The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior." [GOC:mtg_kidney_jan10, PMID:10535314, PMID:18226983, XAO:0001015] synonym: "pronephric rectal diverticulum development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039010 name: specification of pronephric distal tubule identity namespace: biological_process def: "The process in which the distal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0039005 ! specification of pronephric tubule identity is_a: GO:0072084 ! specification of distal tubule identity is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development relationship: part_of GO:0039013 ! pronephric distal tubule morphogenesis [Term] id: GO:0039011 name: pronephric proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10] synonym: "pronephros proximal tubule morphogenesis" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0039008 ! pronephric nephron tubule morphogenesis is_a: GO:0072158 ! proximal tubule morphogenesis relationship: part_of GO:0035776 ! pronephric proximal tubule development [Term] id: GO:0039012 name: pronephric sinus development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules." [GOC:mtg_kidney_jan10, PMID:10535314, XAO:0000385] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039013 name: pronephric distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10] is_a: GO:0039008 ! pronephric nephron tubule morphogenesis is_a: GO:0072156 ! distal tubule morphogenesis relationship: part_of GO:0035777 ! pronephric distal tubule development [Term] id: GO:0039014 name: cell differentiation involved in pronephros development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "cell differentiation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039015 name: cell proliferation involved in pronephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros." [GOC:mtg_kidney_jan10] synonym: "cell proliferation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039016 name: cell-cell signaling involved in pronephros development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] synonym: "cell-cell signaling involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in pronephros development" EXACT [GOC:mah] is_a: GO:0060995 ! cell-cell signaling involved in kidney development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039017 name: pattern specification involved in pronephros development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039018 name: nephrostome development namespace: biological_process def: "The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity." [GOC:mtg_kidney_jan10, PMID:14686690, PMID:15647339, XAO:0000062] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039019 name: pronephric nephron development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10, XAO:00002785] is_a: GO:0072006 ! nephron development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039020 name: pronephric nephron tubule development namespace: biological_process def: "The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct." [GOC:mtg_kidney_jan10, PMID:19909807, PMID:9268568] is_a: GO:0072080 ! nephron tubule development relationship: part_of GO:0039019 ! pronephric nephron development [Term] id: GO:0039021 name: pronephric glomerulus development namespace: biological_process def: "The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:dgh, GOC:mtg_kidney_jan10, ZFA:00001557] comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. is_a: GO:0032835 ! glomerulus development relationship: part_of GO:0039019 ! pronephric nephron development [Term] id: GO:0039022 name: pronephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney." [GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150] is_a: GO:0072176 ! nephric duct development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0039023 name: pronephric duct morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney." [GOC:mtg_kidney_jan10, XAO:0000063, ZFA:0000150] is_a: GO:0072178 ! nephric duct morphogenesis relationship: part_of GO:0039022 ! pronephric duct development relationship: part_of GO:0072114 ! pronephros morphogenesis [Term] id: GO:0039501 name: suppression by virus of host type I interferon production namespace: biological_process def: "Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp] synonym: "negative regulation by virus of host type I interferon production" EXACT [GOC:bf] synonym: "suppression by virus of host interferon type I production" EXACT [GOC:bf] synonym: "suppression by virus of host type I IFN production" EXACT [GOC:bf] is_a: GO:0046775 ! suppression by virus of host cytokine production [Term] id: GO:0039502 name: suppression by virus of host type I interferon-mediated signaling pathway namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp] synonym: "negative regulation by virus of host type I interferon-mediated signaling pathway" EXACT [GOC:bf] synonym: "suppression by virus of host type I IFN-mediated signaling pathway" EXACT [GOC:bf] synonym: "suppression by virus of host type I interferon-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0039503 ! suppression by virus of host innate immunity is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction [Term] id: GO:0039503 name: suppression by virus of host innate immunity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense." [GOC:add, GOC:bf, GOC:sp] synonym: "negative regulation by virus of host innate immune response" EXACT [GOC:bf] synonym: "negative regulation by virus of host innate immunity " EXACT [GOC:bf] is_a: GO:0030683 ! evasion by virus of host immune response is_a: GO:0052170 ! negative regulation by symbiont of host innate immunity [Term] id: GO:0039504 name: suppression by virus of host adaptive immune response namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GOC:add, GOC:bf, GOC:sp] synonym: "negative regulation by virus of host adaptive immune response" EXACT [GOC:bf] synonym: "negative regulation by virus of host adaptive immunity" EXACT [GOC:bf] synonym: "suppression by virus of host acquired immune response" EXACT [ISBN:068340007X "Stedman's Medical Dictionary"] is_a: GO:0030683 ! evasion by virus of host immune response is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0039505 name: suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, GOC:bf] is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response [Term] id: GO:0039506 name: modulation by virus of host molecular function namespace: biological_process def: "The process in which a virus effects a change in the function of a host protein via a direct interaction." [GOC:bf, GOC:sp] synonym: "modification by virus of host protein function" EXACT [GOC:bf] is_a: GO:0019048 ! virus-host interaction is_a: GO:0052055 ! modulation by symbiont of host molecular function [Term] id: GO:0039507 name: suppression by virus of host molecular function namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein." [GOC:bf, GOC:sp] synonym: "down regulation by virus of host protein function" EXACT [GOC:bf] synonym: "down-regulation by virus of host protein function" EXACT [GOC:bf] synonym: "inhibition by virus of host protein function" EXACT [GOC:bf] synonym: "inhibition of host protein function" BROAD [GOC:bf] synonym: "negative regulation by virus of host molecular function" EXACT [GOC:bf] synonym: "negative regulation by virus of host protein function" EXACT [GOC:bf] is_a: GO:0039506 ! modulation by virus of host molecular function is_a: GO:0052056 ! negative regulation by symbiont of host molecular function [Term] id: GO:0039508 name: suppression by virus of host receptor activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor." [GOC:bf, GOC:sp] synonym: "down-regulation by virus of host receptor activity" EXACT [GOC:bf] synonym: "downregulation by virus of host receptor activity" EXACT [GOC:bf] synonym: "inhibition by virus of host receptor activity" EXACT [GOC:bf] synonym: "negative regulation by virus of host receptor activity" EXACT [GOC:bf] synonym: "suppression by virus of host receptor function" EXACT [GOC:bf] synonym: "viral inhibition of host receptor" EXACT [GOC:bf] is_a: GO:0039507 ! suppression by virus of host molecular function [Term] id: GO:0039509 name: suppression by virus of host pattern recognition receptor activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity." [GOC:bf, GOC:sp] synonym: "down regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf] synonym: "down-regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf] synonym: "inhibition by virus of host pattern recognition receptor activity" EXACT [GOC:rf] synonym: "negative regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf] synonym: "suppression by virus of host pattern recognition receptor function" EXACT [GOC:bf] synonym: "viral inhibition of host pattern recognition receptor activity" EXACT [GOC:bf] is_a: GO:0039508 ! suppression by virus of host receptor activity [Term] id: GO:0040001 name: establishment of mitotic spindle localization namespace: biological_process alt_id: GO:0018986 alt_id: GO:0030605 alt_id: GO:0030606 alt_id: GO:0030608 alt_id: GO:0030610 def: "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai] synonym: "establishment of mitotic spindle localisation" EXACT [GOC:mah] synonym: "mitotic spindle positioning" EXACT [] synonym: "mitotic spindle positioning and orientation" NARROW [] synonym: "mitotic spindle positioning or orientation" EXACT [] synonym: "spindle positioning during mitosis" RELATED [] synonym: "spindle positioning involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process is_a: GO:0051293 ! establishment of spindle localization relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0040002 name: collagen and cuticulin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu] synonym: "collagen and cuticulin-based cuticle anabolism" EXACT [] synonym: "collagen and cuticulin-based cuticle biosynthetic process" EXACT [] synonym: "collagen and cuticulin-based cuticle formation" EXACT [] synonym: "collagen and cuticulin-based cuticle synthesis" EXACT [] is_a: GO:0007592 ! protein-based cuticle development [Term] id: GO:0040003 name: chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] synonym: "chitin-based cuticle anabolism" EXACT [] synonym: "chitin-based cuticle biosynthetic process" EXACT [] synonym: "chitin-based cuticle formation" EXACT [] synonym: "chitin-based cuticle synthesis" EXACT [] is_a: GO:0042335 ! cuticle development [Term] id: GO:0040004 name: collagen and cuticulin-based cuticle attachment to epithelium namespace: biological_process def: "Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu] synonym: "cuticular attachment to epithelium" BROAD [] is_a: GO:0040006 ! protein-based cuticle attachment to epithelium relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle [Term] id: GO:0040005 name: chitin-based cuticle attachment to epithelium namespace: biological_process def: "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "cuticular attachment to epithelium" BROAD [] is_a: GO:0040006 ! protein-based cuticle attachment to epithelium relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0040006 name: protein-based cuticle attachment to epithelium namespace: biological_process def: "Attaching of a protein-based cuticle to the epithelium underlying it." [GOC:jl, GOC:mtg_sensu] synonym: "cuticular attachment to epithelium" BROAD [] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0018988 ! molting cycle, protein-based cuticle [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0040008 name: regulation of growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0040007 ! growth [Term] id: GO:0040009 name: regulation of growth rate namespace: biological_process def: "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah] comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. is_a: GO:0040008 ! regulation of growth [Term] id: GO:0040010 name: positive regulation of growth rate namespace: biological_process def: "Any process that increases the rate of growth of all or part of an organism." [GOC:mah] comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. synonym: "activation of growth rate" NARROW [] synonym: "stimulation of growth rate" NARROW [] synonym: "up regulation of growth rate" EXACT [] synonym: "up-regulation of growth rate" EXACT [] synonym: "upregulation of growth rate" EXACT [] is_a: GO:0040009 ! regulation of growth rate is_a: GO:0045927 ! positive regulation of growth [Term] id: GO:0040011 name: locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] subset: goslim_generic subset: goslim_pir subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0040012 name: regulation of locomotion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0040011 ! locomotion [Term] id: GO:0040013 name: negative regulation of locomotion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "down regulation of locomotion" EXACT [] synonym: "down-regulation of locomotion" EXACT [] synonym: "downregulation of locomotion" EXACT [] synonym: "inhibition of locomotion" NARROW [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0040011 ! locomotion [Term] id: GO:0040014 name: regulation of multicellular organism growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040008 ! regulation of growth is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0035264 ! multicellular organism growth [Term] id: GO:0040015 name: negative regulation of multicellular organism growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0045926 ! negative regulation of growth is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0035264 ! multicellular organism growth [Term] id: GO:0040016 name: embryonic cleavage namespace: biological_process def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] is_a: GO:0051301 ! cell division relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0040017 name: positive regulation of locomotion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "activation of locomotion" NARROW [] synonym: "stimulation of locomotion" NARROW [] synonym: "up regulation of locomotion" EXACT [] synonym: "up-regulation of locomotion" EXACT [] synonym: "upregulation of locomotion" EXACT [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0040011 ! locomotion [Term] id: GO:0040018 name: positive regulation of multicellular organism growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0035264 ! multicellular organism growth [Term] id: GO:0040019 name: positive regulation of embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "activation of embryonic development" NARROW [] synonym: "stimulation of embryonic development" NARROW [] synonym: "up regulation of embryonic development" EXACT [] synonym: "up-regulation of embryonic development" EXACT [] synonym: "upregulation of embryonic development" EXACT [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0009790 ! embryo development [Term] id: GO:0040020 name: regulation of meiosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle relationship: regulates GO:0007126 ! meiosis [Term] id: GO:0040021 name: hermaphrodite germ-line sex determination namespace: biological_process alt_id: GO:0042005 def: "The determination of sex and sexual phenotype in the germ line of a hermaphrodite." [GOC:ems] is_a: GO:0018992 ! germ-line sex determination [Term] id: GO:0040022 name: feminization of hermaphroditic germ-line namespace: biological_process def: "The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite." [GOC:ems] is_a: GO:0040021 ! hermaphrodite germ-line sex determination [Term] id: GO:0040023 name: establishment of nucleus localization namespace: biological_process def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] synonym: "establishment of cell nucleus localization" EXACT [] synonym: "establishment of localization of nucleus" EXACT [] synonym: "establishment of nucleus localisation" EXACT [GOC:mah] synonym: "establishment of position of nucleus" EXACT [] synonym: "nuclear positioning" EXACT [] synonym: "nucleus positioning" EXACT [] synonym: "positioning of nucleus" EXACT [] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0051647 ! nucleus localization [Term] id: GO:0040024 name: dauer larval development namespace: biological_process def: "The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:ems, ISBN:087969307X] is_a: GO:0002119 ! nematode larval development [Term] id: GO:0040025 name: vulval development namespace: biological_process def: "The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv, ISBN:087969307X] is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0002119 ! nematode larval development [Term] id: GO:0040026 name: positive regulation of vulval development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv] synonym: "activation of vulval development" RELATED [] synonym: "stimulation of vulval development" RELATED [] synonym: "up regulation of vulval development" RELATED [] synonym: "up-regulation of vulval development" RELATED [] synonym: "upregulation of vulval development" RELATED [] is_a: GO:0040028 ! regulation of vulval development is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0040025 ! vulval development [Term] id: GO:0040027 name: negative regulation of vulval development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv] synonym: "down regulation of vulval development" EXACT [] synonym: "down-regulation of vulval development" EXACT [] synonym: "downregulation of vulval development" EXACT [] synonym: "inhibition of vulval development" NARROW [] synonym: "negative regulation of vulval development" EXACT [] is_a: GO:0040028 ! regulation of vulval development is_a: GO:0061064 ! negative regulation of nematode larval development relationship: negatively_regulates GO:0040025 ! vulval development [Term] id: GO:0040028 name: regulation of vulval development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:kmv, GOC:ma] is_a: GO:0061062 ! regulation of nematode larval development relationship: regulates GO:0040025 ! vulval development [Term] id: GO:0040029 name: regulation of gene expression, epigenetic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582] subset: goslim_plant subset: gosubset_prok is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0040030 name: regulation of molecular function, epigenetic namespace: biological_process def: "Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551] synonym: "regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0040031 name: snRNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl] is_a: GO:0009451 ! RNA modification is_a: GO:0016073 ! snRNA metabolic process [Term] id: GO:0040032 name: post-embryonic body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the post-embryonic soma are generated and organized." [GOC:ems, ISBN:0140512888] comment: Note that this term was 'body morphogenesis (sensu Nematoda)'. is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0010171 ! body morphogenesis [Term] id: GO:0040033 name: negative regulation of translation, ncRNA-mediated namespace: biological_process def: "Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:ems, GOC:tb] synonym: "down regulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "down-regulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "downregulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "inhibition of mRNA translation, ncRNA-mediated" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0045974 ! regulation of translation, ncRNA-mediated [Term] id: GO:0040034 name: regulation of development, heterochronic namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the progression an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition at a consistent predetermined time point during its development." [PMID:9442909] synonym: "developmental timing" RELATED [] synonym: "heterochronic regulation of development" EXACT [] synonym: "temporal regulation of development" EXACT [] is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0040035 name: hermaphrodite genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures." [GOC:ems, ISBN:0140512888] is_a: GO:0048806 ! genitalia development [Term] id: GO:0040036 name: regulation of fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "regulation of FGF receptor signaling pathway" EXACT [] synonym: "regulation of FGF receptor signalling pathway" EXACT [] synonym: "regulation of FGFR signaling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0040037 name: negative regulation of fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "down regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of fibroblast growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of FGF receptor signaling pathway" EXACT [] synonym: "negative regulation of FGF receptor signalling pathway" EXACT [] synonym: "negative regulation of FGFR signaling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway relationship: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0040038 name: polar body extrusion after meiotic divisions namespace: biological_process def: "The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0033206 ! cytokinesis after meiosis relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0040039 name: inductive cell migration namespace: biological_process def: "Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans." [ISBN:087969307X, ISBN:0879694882] is_a: GO:0016477 ! cell migration [Term] id: GO:0040040 name: thermosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of temperature." [GOC:ems] synonym: "behavioral response to temperature stimulus" EXACT [] synonym: "behavioural response to temperature stimulus" EXACT [] synonym: "thermosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0042000 name: translocation of peptides or proteins into host namespace: biological_process def: "The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "transport of peptides or proteins into host" EXACT [] is_a: GO:0044417 ! translocation of molecules into host is_a: GO:0051808 ! translocation of peptides or proteins into other organism involved in symbiotic interaction [Term] id: GO:0042001 name: hermaphrodite somatic sex determination namespace: biological_process alt_id: GO:0042002 def: "The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans." [GOC:ems] is_a: GO:0018993 ! somatic sex determination [Term] id: GO:0042003 name: masculinization of hermaphrodite soma namespace: biological_process def: "Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans." [GOC:ems] is_a: GO:0042001 ! hermaphrodite somatic sex determination [Term] id: GO:0042004 name: feminization of hermaphrodite soma namespace: biological_process def: "Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans." [GOC:ems] is_a: GO:0042001 ! hermaphrodite somatic sex determination [Term] id: GO:0042006 name: masculinization of hermaphroditic germ-line namespace: biological_process def: "The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans." [GOC:ems] is_a: GO:0040021 ! hermaphrodite germ-line sex determination [Term] id: GO:0042007 name: interleukin-18 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-18." [GOC:jl] synonym: "IL-18 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042008 name: interleukin-18 receptor activity namespace: molecular_function def: "Combining with interleukin-18 to initiate a change in cell activity." [GOC:jl] synonym: "IL-18 receptor activity" EXACT [GOC:mah] synonym: "IL-18R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0042007 ! interleukin-18 binding [Term] id: GO:0042009 name: interleukin-15 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-15." [GOC:jl] synonym: "IL-15 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042010 name: interleukin-15 receptor activity namespace: molecular_function def: "Combining with interleukin-15 to initiate a change in cell activity." [GOC:jl] synonym: "IL-15 receptor activity" EXACT [GOC:mah] synonym: "IL-15R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0042009 ! interleukin-15 binding [Term] id: GO:0042011 name: interleukin-16 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-16." [GOC:jl] synonym: "IL-16 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042012 name: interleukin-16 receptor activity namespace: molecular_function def: "Combining with interleukin-16 to initiate a change in cell activity." [GOC:jl] synonym: "IL-16 receptor activity" EXACT [GOC:mah] synonym: "IL-16R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0042011 ! interleukin-16 binding [Term] id: GO:0042013 name: interleukin-19 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-19." [GOC:jl] synonym: "IL-19 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042014 name: interleukin-19 receptor activity namespace: molecular_function def: "Combining with interleukin-19 to initiate a change in cell activity." [GOC:jl] synonym: "IL-19 receptor activity" EXACT [GOC:mah] synonym: "IL-19R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0042013 ! interleukin-19 binding [Term] id: GO:0042015 name: interleukin-20 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-20." [GOC:jl] synonym: "IL-20 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042016 name: interleukin-20 receptor activity namespace: molecular_function def: "Combining with interleukin-20 to initiate a change in cell activity." [GOC:jl] synonym: "IL-20 receptor activity" EXACT [GOC:mah] synonym: "IL-20R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0042015 ! interleukin-20 binding [Term] id: GO:0042017 name: interleukin-22 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-22." [GOC:jl] synonym: "IL-22 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042018 name: interleukin-22 receptor activity namespace: molecular_function def: "Combining with interleukin-22 to initiate a change in cell activity." [GOC:jl] synonym: "IL-22 receptor activity" EXACT [GOC:mah] synonym: "IL-22R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0042017 ! interleukin-22 binding [Term] id: GO:0042019 name: interleukin-23 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-23." [GOC:jl] synonym: "IL-23 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042020 name: interleukin-23 receptor activity namespace: molecular_function def: "Combining with interleukin-23 to initiate a change in cell activity." [GOC:jl] synonym: "IL-23 receptor activity" EXACT [GOC:mah] synonym: "IL-23R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0042019 ! interleukin-23 binding [Term] id: GO:0042021 name: granulocyte macrophage colony-stimulating factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor complex." [GOC:ai] synonym: "GM-CSF complex binding" EXACT [] synonym: "GMC-SF complex binding" EXACT [] synonym: "granulocyte macrophage colony stimulating factor complex binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042022 name: interleukin-12 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-12; comprises a beta1 and a beta2 subunit." [GOC:ebc, GOC:mah, PMID:10971505] synonym: "IL-12 receptor complex" EXACT [GOC:add] synonym: "IL12RB1-IL12RB2 complex" NARROW [CORUM:2026] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0042023 name: DNA endoreduplication namespace: biological_process def: "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl] comment: Note that this term is only to be used in situations were this process occurs normally. Not to be used to describe mutant or diseased states. subset: gosubset_prok synonym: "DNA endoreplication" EXACT [] synonym: "DNA re-duplication" EXACT [] is_a: GO:0006261 ! DNA-dependent DNA replication is_a: GO:0022402 ! cell cycle process [Term] id: GO:0042025 name: host cell nucleus namespace: cellular_component alt_id: GO:0033649 def: "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0033648 ! host intracellular membrane-bounded organelle [Term] id: GO:0042026 name: protein refolding namespace: biological_process def: "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] subset: gosubset_prok synonym: "heat shock protein activity" RELATED [] is_a: GO:0006457 ! protein folding [Term] id: GO:0042027 name: cyclophilin-type peptidyl-prolyl cis-trans isomerase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0)." [EC:5.2.1.8] comment: This term was made obsolete because it is contains gene product specific characteristics. is_obsolete: true consider: GO:0003755 [Term] id: GO:0042029 name: fibrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [EC:3.4.24.72, PMID:7725320] comment: This term was made obsolete because it represents a gene product. synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [EC:3.4.24.72] synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [EC:3.4.24.72] synonym: "fibrinolytic proteinase activity" EXACT [EC:3.4.24.72] xref: EC:3.4.24.72 xref: MetaCyc:3.4.24.72-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0042030 name: ATPase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate." [GOC:jl] synonym: "adenosinetriphosphatase inhibitor" EXACT [] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0060590 ! ATPase regulator activity [Term] id: GO:0042031 name: angiotensin-converting enzyme inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I." [GOC:jl] comment: This term was made obsolete because it represents a regulator of a non-existent molecular function term. synonym: "ACE inhibitor" EXACT [] synonym: "peptidyl dipeptidase A inhibitor" EXACT [] xref: Wikipedia:ACE_inhibitor is_obsolete: true replaced_by: GO:0060422 [Term] id: GO:0042033 name: chemokine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "chemokine anabolism" EXACT [] synonym: "chemokine biosynthesis" EXACT [] synonym: "chemokine formation" EXACT [] synonym: "chemokine synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:0050755 ! chemokine metabolic process relationship: part_of GO:0032602 ! chemokine production [Term] id: GO:0042034 name: peptidyl-lysine esterification namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-L-lysine methyl ester." [RESID:AA0318] subset: gosubset_prok xref: RESID:AA0318 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0042035 name: regulation of cytokine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators] synonym: "regulation of cytokine anabolism" EXACT [] synonym: "regulation of cytokine biosynthesis" EXACT [] synonym: "regulation of cytokine formation" EXACT [] synonym: "regulation of cytokine synthesis" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051246 ! regulation of protein metabolic process relationship: regulates GO:0042089 ! cytokine biosynthetic process [Term] id: GO:0042036 name: negative regulation of cytokine biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators] synonym: "down regulation of cytokine biosynthetic process" EXACT [] synonym: "down-regulation of cytokine biosynthetic process" EXACT [] synonym: "downregulation of cytokine biosynthetic process" EXACT [] synonym: "inhibition of cytokine biosynthetic process" NARROW [] synonym: "negative regulation of cytokine anabolism" EXACT [] synonym: "negative regulation of cytokine biosynthesis" EXACT [] synonym: "negative regulation of cytokine formation" EXACT [] synonym: "negative regulation of cytokine synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0042035 ! regulation of cytokine biosynthetic process is_a: GO:0051248 ! negative regulation of protein metabolic process relationship: negatively_regulates GO:0042089 ! cytokine biosynthetic process [Term] id: GO:0042037 name: peptidyl-histidine methylation, to form pros-methylhistidine namespace: biological_process alt_id: GO:0042260 def: "The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073] subset: gosubset_prok synonym: "peptidyl-histidine pros-methylation" EXACT [] xref: RESID:AA0073 is_a: GO:0018021 ! peptidyl-histidine methylation [Term] id: GO:0042038 name: peptidyl-histidine methylation, to form tele-methylhistidine namespace: biological_process alt_id: GO:0042261 def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine)." [RESID:AA0317] subset: gosubset_prok synonym: "peptidyl-histidine tele-methylation" EXACT [] xref: RESID:AA0317 is_a: GO:0018021 ! peptidyl-histidine methylation [Term] id: GO:0042039 name: vanadium incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n)." [PMID:11053414] subset: gosubset_prok synonym: "vanadium incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0042040 name: metal incorporation into metallo-molybdopterin complex namespace: biological_process def: "The incorporation of a metal into a metallo-molybdopterin complex." [GOC:ai] subset: gosubset_prok is_a: GO:0006464 ! protein modification process [Term] id: GO:0042042 name: tungsten incorporation into tungsten-molybdopterin complex namespace: biological_process def: "The incorporation of tungsten into a tungsten-molybdopterin complex." [GOC:ai] subset: gosubset_prok is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex [Term] id: GO:0042043 name: neurexin binding namespace: molecular_function alt_id: GO:0019963 def: "Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, PMID:18923512] synonym: "neuroligin" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042044 name: fluid transport namespace: biological_process def: "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0042045 name: epithelial fluid transport namespace: biological_process def: "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830] is_a: GO:0042044 ! fluid transport [Term] id: GO:0042046 name: W-molybdopterin cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257] subset: gosubset_prok synonym: "Moco metabolic process" BROAD [] synonym: "Moco metabolism" BROAD [] synonym: "W-molybdopterin cofactor metabolism" EXACT [] is_a: GO:0043545 ! molybdopterin cofactor metabolic process [Term] id: GO:0042047 name: W-molybdopterin cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257] subset: gosubset_prok synonym: "Moco biosynthesis" BROAD [] synonym: "Moco biosynthetic process" BROAD [] synonym: "W-molybdopterin cofactor anabolism" EXACT [] synonym: "W-molybdopterin cofactor biosynthesis" EXACT [] synonym: "W-molybdopterin cofactor formation" EXACT [] synonym: "W-molybdopterin cofactor synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process [Term] id: GO:0042048 name: olfactory behavior namespace: biological_process def: "The actions or reactions of an organism in response to an odor." [GOC:jid] synonym: "behavioral response to scent" EXACT [] synonym: "behavioral response to smell" EXACT [] synonym: "behavioural response to odour" EXACT [] synonym: "behavioural response to scent" EXACT [] synonym: "behavioural response to smell" EXACT [] synonym: "olfactory behaviour" EXACT [] is_a: GO:0007635 ! chemosensory behavior [Term] id: GO:0042049 name: cellular acyl-CoA homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "cell acyl-CoA homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0042051 name: compound eye photoreceptor development namespace: biological_process def: "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] synonym: "adult eye photoreceptor development" NARROW [] is_a: GO:0042462 ! eye photoreceptor cell development relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0042052 name: rhabdomere development namespace: biological_process def: "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] synonym: "rhabdomere organization" EXACT [GOC:mah] is_a: GO:0006996 ! organelle organization relationship: part_of GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0042053 name: regulation of dopamine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] synonym: "regulation of dopamine metabolism" EXACT [] is_a: GO:0042069 ! regulation of catecholamine metabolic process relationship: regulates GO:0042417 ! dopamine metabolic process [Term] id: GO:0042054 name: histone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [EC:2.1.1.43] synonym: "histone methylase activity" EXACT [GOC:mah] is_a: GO:0008276 ! protein methyltransferase activity [Term] id: GO:0042056 name: chemoattractant activity namespace: molecular_function def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "attractant" BROAD [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0042057 name: transforming growth factor beta receptor anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location." [GOC:ai] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "TGF-beta receptor anchoring activity" EXACT [] synonym: "TGFbeta receptor anchoring activity" EXACT [] synonym: "transforming growth factor beta receptor anchor activity" EXACT [] is_obsolete: true replaced_by: GO:0005160 replaced_by: GO:0008104 [Term] id: GO:0042058 name: regulation of epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "regulation of EGF receptor signaling pathway" EXACT [] synonym: "regulation of EGF receptor signalling pathway" EXACT [] synonym: "regulation of EGFR signaling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0042059 name: negative regulation of epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "down regulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of epidermal growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of EGF receptor signaling pathway" EXACT [] synonym: "negative regulation of EGF receptor signalling pathway" EXACT [] synonym: "negative regulation of EGFR signaling pathway" EXACT [] xref: Reactome:1253417 "EGFR downregulation" xref: Reactome:1280357 "EGFR downregulation" xref: Reactome:1299196 "EGFR downregulation" xref: Reactome:1326935 "EGFR downregulation" xref: Reactome:1353030 "EGFR downregulation" xref: Reactome:1373222 "EGFR downregulation" xref: Reactome:1393239 "EGFR downregulation" xref: Reactome:1417732 "EGFR downregulation" xref: Reactome:1450831 "EGFR downregulation" xref: Reactome:1471239 "EGFR downregulation" xref: Reactome:1483228 "EGFR downregulation" xref: Reactome:182971 "EGFR downregulation" is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway relationship: negatively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0042060 name: wound healing namespace: biological_process def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] xref: Wikipedia:Wound_healing is_a: GO:0009611 ! response to wounding [Term] id: GO:0042062 name: long-term strengthening of neuromuscular junction namespace: biological_process def: "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GO_REF:0000021, GOC:mtg_15jun06_goc\:pd] comment: This term was added by GO_REF:0000021. is_a: GO:0050806 ! positive regulation of synaptic transmission relationship: part_of GO:0008582 ! regulation of synaptic growth at neuromuscular junction [Term] id: GO:0042063 name: gliogenesis namespace: biological_process def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid] synonym: "glial cell generation" EXACT systematic_synonym [] is_a: GO:0022008 ! neurogenesis [Term] id: GO:0042064 name: cell adhesion receptor regulator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0005102 consider: GO:0030155 [Term] id: GO:0042065 name: glial cell growth namespace: biological_process def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0042066 name: perineurial glial growth namespace: biological_process def: "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560] is_a: GO:0042065 ! glial cell growth [Term] id: GO:0042067 name: establishment of ommatidial planar polarity namespace: biological_process def: "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] synonym: "establishment of ommatidial polarity" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0042068 name: regulation of pteridine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of pteridine metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: regulates GO:0019889 ! pteridine metabolic process [Term] id: GO:0042069 name: regulation of catecholamine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of catecholamine metabolism" EXACT [] is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0006584 ! catecholamine metabolic process [Term] id: GO:0042070 name: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0048127 def: "Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] synonym: "maintenance of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb] synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] synonym: "maintenance of oocyte nucleus location involved in oocyte dorsoventral axis specification" EXACT [GOC:mah] synonym: "maintenance of oocyte nucleus position during oocyte axis determination" BROAD [] synonym: "oocyte axis determination, maintenance of oocyte nucleus localization" BROAD [] synonym: "oocyte axis determination, maintenance of oocyte nucleus position" BROAD [] synonym: "oocyte axis determination, oocyte nucleus anchoring" BROAD [] synonym: "oocyte nucleus anchoring during oocyte axis determination" BROAD [] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051658 ! maintenance of nucleus location relationship: part_of GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [Term] id: GO:0042071 name: leucokinin receptor activity namespace: molecular_function def: "Combining with a leucokinin, any of several octapeptide hormones found in insects, to initiate a change in cell activity." [GOC:mah, PMID:2716741] is_a: GO:0004872 ! receptor activity [Term] id: GO:0042072 name: cell adhesion receptor inhibitor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0005102 consider: GO:0007162 [Term] id: GO:0042073 name: intraflagellar transport namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium or flagellum, mediated by motor proteins." [GOC:kmv, PMID:17981739, PMID:18180368] xref: Wikipedia:Intraflagellar_transport is_a: GO:0010970 ! microtubule-based transport relationship: part_of GO:0030030 ! cell projection organization [Term] id: GO:0042074 name: cell migration involved in gastrulation namespace: biological_process def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437] is_a: GO:0001667 ! ameboidal cell migration relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0042075 name: nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide namespace: biological_process def: "The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310] subset: gosubset_prok synonym: "nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT [] xref: RESID:AA0310 is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster [Term] id: GO:0042076 name: protein phosphate-linked glycosylation namespace: biological_process def: "The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [PMID:7499424] subset: gosubset_prok synonym: "phosphoglycosylation" EXACT [] synonym: "protein amino acid phosphate-linked glycosylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0042077 name: protein phosphate-linked glycosylation via serine namespace: biological_process def: "The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [GOC:mah] subset: gosubset_prok synonym: "protein amino acid phosphate-linked glycosylation via serine" EXACT [GOC:bf] is_a: GO:0042076 ! protein phosphate-linked glycosylation [Term] id: GO:0042078 name: germ-line stem cell division namespace: biological_process alt_id: GO:0048131 def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] synonym: "germ-line stem cell renewal" EXACT [] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0017145 ! stem cell division is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007281 ! germ cell development [Term] id: GO:0042079 name: GPI/GSI anchor metabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a composite term that represents two individual processes. is_obsolete: true consider: GO:0006505 consider: GO:0042081 [Term] id: GO:0042080 name: GPI/GSI anchor biosynthetic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a composite term that represents two individual processes. synonym: "GPI/GSI anchor anabolism" EXACT [] synonym: "GPI/GSI anchor biosynthesis" EXACT [] synonym: "GPI/GSI anchor formation" EXACT [] synonym: "GPI/GSI anchor synthesis" EXACT [] is_obsolete: true consider: GO:0006506 consider: GO:0042082 [Term] id: GO:0042081 name: GSI anchor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane." [GOC:go_curators] subset: gosubset_prok synonym: "GPI/GSI anchor metabolic process" BROAD [] synonym: "GPI/GSI anchor metabolism" BROAD [] synonym: "GSI anchor metabolism" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0042082 name: GSI anchor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage." [GOC:go_curators, GOC:jsg] subset: gosubset_prok synonym: "GPI/GSI anchor biosynthesis" BROAD [] synonym: "GPI/GSI anchor biosynthetic process" BROAD [] synonym: "GSI anchor anabolism" EXACT [] synonym: "GSI anchor biosynthesis" EXACT [] synonym: "GSI anchor formation" EXACT [] synonym: "GSI anchor synthesis" EXACT [] is_a: GO:0006497 ! protein lipidation is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0042081 ! GSI anchor metabolic process [Term] id: GO:0042083 name: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate." [GOC:ai] subset: gosubset_prok is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0042084 name: 5-methyltetrahydrofolate-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate." [GOC:ai] subset: gosubset_prok is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0042085 name: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate." [GOC:ai] subset: gosubset_prok is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0042086 name: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin." [GOC:ai] subset: gosubset_prok is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0042088 name: T-helper 1 type immune response namespace: biological_process def: "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "Th1 immune response" EXACT [] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0042089 name: cytokine biosynthetic process namespace: biological_process alt_id: GO:0042032 def: "The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0198599471] synonym: "cytokine anabolism" EXACT [] synonym: "cytokine biosynthesis" EXACT [] synonym: "cytokine formation" EXACT [] synonym: "cytokine synthesis" EXACT [] synonym: "induction of cytokines" NARROW [] is_a: GO:0042107 ! cytokine metabolic process relationship: part_of GO:0001816 ! cytokine production [Term] id: GO:0042090 name: interleukin-12 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] synonym: "IL-12 biosynthesis" EXACT [] synonym: "IL-12 biosynthetic process" EXACT [] synonym: "interleukin-12 anabolism" EXACT [] synonym: "interleukin-12 biosynthesis" EXACT [] synonym: "interleukin-12 formation" EXACT [] synonym: "interleukin-12 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032615 ! interleukin-12 production [Term] id: GO:0042091 name: interleukin-10 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] synonym: "IL-10 biosynthesis" EXACT [] synonym: "IL-10 biosynthetic process" EXACT [] synonym: "interleukin-10 anabolism" EXACT [] synonym: "interleukin-10 biosynthesis" EXACT [] synonym: "interleukin-10 formation" EXACT [] synonym: "interleukin-10 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032613 ! interleukin-10 production [Term] id: GO:0042092 name: type 2 immune response namespace: biological_process def: "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:18000958, PMID:18007680, PMID:20065995, PMID:20200518] synonym: "T-helper 2 type immune response" NARROW [GOC:add] synonym: "Th2 immune response" NARROW [GOC:add] is_a: GO:0006955 ! immune response [Term] id: GO:0042093 name: T-helper cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc] synonym: "helper T cell differentiation" EXACT [CL:0000912] synonym: "T-helper cell development" RELATED [GOC:add] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response [Term] id: GO:0042094 name: interleukin-2 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] synonym: "IL-2 biosynthesis" EXACT [] synonym: "IL-2 biosynthetic process" EXACT [] synonym: "interleukin-2 anabolism" EXACT [] synonym: "interleukin-2 biosynthesis" EXACT [] synonym: "interleukin-2 formation" EXACT [] synonym: "interleukin-2 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032623 ! interleukin-2 production [Term] id: GO:0042095 name: interferon-gamma biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] synonym: "IFN-gamma biosynthesis" EXACT [] synonym: "IFN-gamma biosynthetic process" EXACT [] synonym: "interferon type II biosynthesis" EXACT [] synonym: "interferon type II biosynthetic process" EXACT [] synonym: "interferon-gamma anabolism" EXACT [] synonym: "interferon-gamma biosynthesis" EXACT [] synonym: "interferon-gamma formation" EXACT [] synonym: "interferon-gamma synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032609 ! interferon-gamma production [Term] id: GO:0042096 name: alpha-beta T cell receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes a receptor type, and not an activity. is_obsolete: true consider: GO:0032394 consider: GO:0032395 consider: GO:0042605 [Term] id: GO:0042097 name: interleukin-4 biosynthetic process namespace: biological_process alt_id: GO:0042224 def: "The chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] synonym: "IL-4 biosynthesis" EXACT [] synonym: "IL-4 biosynthetic process" EXACT [] synonym: "interleukin-4 anabolism" EXACT [] synonym: "interleukin-4 biosynthesis" EXACT [] synonym: "interleukin-4 formation" EXACT [] synonym: "interleukin-4 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032633 ! interleukin-4 production [Term] id: GO:0042098 name: T cell proliferation namespace: biological_process alt_id: GO:0042111 def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl] synonym: "T lymphocyte proliferation" EXACT [] synonym: "T-cell proliferation" EXACT [] synonym: "T-lymphocyte proliferation" EXACT [] is_a: GO:0042110 ! T cell activation is_a: GO:0046651 ! lymphocyte proliferation [Term] id: GO:0042099 name: gamma-delta T cell receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes a receptor type, and not an activity. is_obsolete: true consider: GO:0032394 consider: GO:0032395 consider: GO:0042605 [Term] id: GO:0042100 name: B cell proliferation namespace: biological_process alt_id: GO:0042114 def: "The expansion of a B cell population by cell division. Follows B cell activation." [GOC:jl] synonym: "B lymphocyte proliferation" EXACT [] synonym: "B-cell proliferation" EXACT [] synonym: "B-lymphocyte proliferation" EXACT [] is_a: GO:0042113 ! B cell activation is_a: GO:0046651 ! lymphocyte proliferation [Term] id: GO:0042101 name: T cell receptor complex namespace: cellular_component def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte receptor complex" EXACT [] synonym: "T-cell receptor complex" EXACT [] synonym: "T-lymphocyte receptor complex" EXACT [] synonym: "TCR" RELATED [] xref: Wikipedia:T_cell_receptor is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0042102 name: positive regulation of T cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai] synonym: "activation of T cell proliferation" NARROW [] synonym: "positive regulation of T lymphocyte proliferation" EXACT [] synonym: "positive regulation of T-lymphocyte proliferation" EXACT [] synonym: "stimulation of T cell proliferation" NARROW [] synonym: "up regulation of T cell proliferation" EXACT [] synonym: "up-regulation of T cell proliferation" EXACT [] synonym: "upregulation of T cell proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation is_a: GO:0050870 ! positive regulation of T cell activation relationship: positively_regulates GO:0042098 ! T cell proliferation [Term] id: GO:0042103 name: positive regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl] synonym: "activation of T cell homeostatic proliferation" NARROW [] synonym: "positive regulation of resting T cell proliferation" EXACT [] synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "positive regulation of T-cell homeostatic proliferation" EXACT [] synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT [] synonym: "stimulation of T cell homeostatic proliferation" NARROW [] synonym: "up regulation of T cell homeostatic proliferation" EXACT [] synonym: "up-regulation of T cell homeostatic proliferation" EXACT [] synonym: "upregulation of T cell homeostatic proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046013 ! regulation of T cell homeostatic proliferation relationship: positively_regulates GO:0001777 ! T cell homeostatic proliferation [Term] id: GO:0042104 name: positive regulation of activated T cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of activated T cell proliferation." [GOC:jl] synonym: "activation of activated T cell proliferation" NARROW [] synonym: "positive regulation of activated T lymphocyte proliferation" EXACT [] synonym: "positive regulation of activated T-cell proliferation" EXACT [] synonym: "positive regulation of activated T-lymphocyte proliferation" EXACT [] synonym: "stimulation of activated T cell proliferation" NARROW [] synonym: "up regulation of activated T cell proliferation" EXACT [] synonym: "up-regulation of activated T cell proliferation" EXACT [] synonym: "upregulation of activated T cell proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046006 ! regulation of activated T cell proliferation relationship: positively_regulates GO:0050798 ! activated T cell proliferation [Term] id: GO:0042105 name: alpha-beta T cell receptor complex namespace: cellular_component def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta T lymphocyte receptor complex" EXACT [] synonym: "alpha-beta T-cell receptor complex" EXACT [] synonym: "alpha-beta T-lymphocyte receptor complex" EXACT [] synonym: "alpha-beta TCR complex" EXACT [] is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042106 name: gamma-delta T cell receptor complex namespace: cellular_component def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"] synonym: "gamma-delta T lymphocyte receptor complex" EXACT [] synonym: "gamma-delta T-cell receptor complex" EXACT [] synonym: "gamma-delta T-lymphocyte receptor complex" EXACT [] synonym: "gamma-delta TCR complex" EXACT [] is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042107 name: cytokine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GO_REF:0000022, GOC:bf, GOC:BHF, GOC:go_curators, GOC:mtg_15nov05, ISBN:0198599471] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "cytokine metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0042108 name: positive regulation of cytokine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators] synonym: "activation of cytokine biosynthetic process" NARROW [] synonym: "positive regulation of cytokine anabolism" EXACT [] synonym: "positive regulation of cytokine biosynthesis" EXACT [] synonym: "positive regulation of cytokine formation" EXACT [] synonym: "positive regulation of cytokine synthesis" EXACT [] synonym: "stimulation of cytokine biosynthetic process" NARROW [] synonym: "up regulation of cytokine biosynthetic process" EXACT [] synonym: "up-regulation of cytokine biosynthetic process" EXACT [] synonym: "upregulation of cytokine biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0042035 ! regulation of cytokine biosynthetic process is_a: GO:0051247 ! positive regulation of protein metabolic process relationship: positively_regulates GO:0042089 ! cytokine biosynthetic process [Term] id: GO:0042109 name: lymphotoxin A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] synonym: "LTA biosynthesis" BROAD [] synonym: "LTA biosynthetic process" BROAD [] synonym: "lymphotoxin A anabolism" EXACT [] synonym: "lymphotoxin A biosynthesis" EXACT [] synonym: "lymphotoxin A formation" EXACT [] synonym: "lymphotoxin A synthesis" EXACT [] synonym: "lymphotoxin-alpha biosynthesis" EXACT [] synonym: "lymphotoxin-alpha biosynthetic process" EXACT [] synonym: "TNF-B biosynthesis" EXACT [] synonym: "TNF-B biosynthetic process" EXACT [] synonym: "TNF-beta biosynthesis" EXACT [] synonym: "TNF-beta biosynthetic process" EXACT [] synonym: "tumor necrosis factor-beta biosynthesis" EXACT [] synonym: "tumor necrosis factor-beta biosynthetic process" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032641 ! lymphotoxin A production [Term] id: GO:0042110 name: T cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140] synonym: "T lymphocyte activation" EXACT [] synonym: "T-cell activation" EXACT [] synonym: "T-lymphocyte activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0042113 name: B cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140] synonym: "B lymphocyte activation" EXACT [] synonym: "B-cell activation" EXACT [] synonym: "B-lymphocyte activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0042116 name: macrophage activation namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology", PMID:14506301] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0042117 name: monocyte activation namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0042118 name: endothelial cell activation namespace: biological_process def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology", PMID:12851652, PMID:14581484] is_a: GO:0001775 ! cell activation [Term] id: GO:0042119 name: neutrophil activation namespace: biological_process def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0042120 name: alginic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alginate metabolic process" EXACT [] synonym: "alginate metabolism" EXACT [] synonym: "alginic acid metabolism" EXACT [] is_a: GO:0010412 ! mannan metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0042121 name: alginic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alginate biosynthesis" EXACT [] synonym: "alginate biosynthetic process" EXACT [] synonym: "alginic acid anabolism" EXACT [] synonym: "alginic acid biosynthesis" EXACT [] synonym: "alginic acid formation" EXACT [] synonym: "alginic acid synthesis" EXACT [] is_a: GO:0042120 ! alginic acid metabolic process is_a: GO:0046354 ! mannan biosynthetic process [Term] id: GO:0042122 name: alginic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alginate catabolic process" EXACT [] synonym: "alginate catabolism" EXACT [] synonym: "alginic acid breakdown" EXACT [] synonym: "alginic acid catabolism" EXACT [] synonym: "alginic acid degradation" EXACT [] is_a: GO:0042120 ! alginic acid metabolic process is_a: GO:0046355 ! mannan catabolic process [Term] id: GO:0042123 name: glucanosyltransferase activity namespace: molecular_function def: "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0042124 name: 1,3-beta-glucanosyltransferase activity namespace: molecular_function def: "Catalysis of the splitting and linkage of 1,3-beta-glucan molecules, resulting in 1,3-beta-glucan chain elongation." [GOC:jl, PMID:10809732] is_a: GO:0042123 ! glucanosyltransferase activity [Term] id: GO:0042125 name: protein galactosylation namespace: biological_process def: "The addition of a galactose molecule to a protein amino acid." [GOC:jl] subset: gosubset_prok synonym: "protein amino acid galactosylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0042126 name: nitrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl] subset: gosubset_prok synonym: "nitrate metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0042127 name: regulation of cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] subset: gosubset_prok is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0008283 ! cell proliferation [Term] id: GO:0042128 name: nitrate assimilation namespace: biological_process def: "The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances." [GOC:das, GOC:mah, PMID:10542156, PMID:8122899] subset: gosubset_prok synonym: "assimilatory nitrate reduction" EXACT [] xref: MetaCyc:PWY-381 is_a: GO:0042126 ! nitrate metabolic process is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0042129 name: regulation of T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl] synonym: "regulation of T lymphocyte proliferation" EXACT [] synonym: "regulation of T-cell proliferation" EXACT [] synonym: "regulation of T-lymphocyte proliferation" EXACT [] is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050863 ! regulation of T cell activation relationship: regulates GO:0042098 ! T cell proliferation [Term] id: GO:0042130 name: negative regulation of T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl] synonym: "down regulation of T cell proliferation" EXACT [] synonym: "down-regulation of T cell proliferation" EXACT [] synonym: "downregulation of T cell proliferation" EXACT [] synonym: "inhibition of T cell proliferation" NARROW [] synonym: "negative regulation of T lymphocyte proliferation" EXACT [] synonym: "negative regulation of T-cell proliferation" EXACT [] synonym: "negative regulation of T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050868 ! negative regulation of T cell activation relationship: negatively_regulates GO:0042098 ! T cell proliferation [Term] id: GO:0042131 name: thiamine phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of thiamine phosphate." [PMID:197075] synonym: "thiamin phosphate phosphatase activity" EXACT [GOC:curators] is_a: GO:0003993 ! acid phosphatase activity [Term] id: GO:0042132 name: fructose 1,6-bisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11] subset: gosubset_prok synonym: "D-fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "D-fructose-1,6-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.11] synonym: "D-fructose-1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "FBPase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-bisphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-diphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose diphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose-1,6-bisphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose-bisphosphatase activity" BROAD [EC:3.1.3.00] synonym: "hexose bisphosphatase activity" EXACT [EC:3.1.3.11] synonym: "hexose diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "hexosediphosphatase activity" BROAD [EC:3.1.3.11] xref: EC:3.1.3.11 xref: MetaCyc:F16BDEPHOS-RXN xref: Reactome:9272 "fructose 1,6-bisphosphate 1-phosphatase activity" is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0042133 name: neurotransmitter metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl] subset: goslim_pir synonym: "neurotransmitter metabolism" EXACT [] xref: Reactome:1243617 "Metabolism of Noradrenaline" xref: Reactome:1270368 "Metabolism of Noradrenaline" xref: Reactome:1293248 "Metabolism of Noradrenaline" xref: Reactome:1316679 "Metabolism of Noradrenaline" xref: Reactome:1343817 "Metabolism of Noradrenaline" xref: Reactome:1366802 "Metabolism of Noradrenaline" xref: Reactome:1386717 "Metabolism of Noradrenaline" xref: Reactome:1409474 "Metabolism of Noradrenaline" xref: Reactome:1439855 "Metabolism of Noradrenaline" xref: Reactome:1539017 "Metabolism of Noradrenaline" xref: Reactome:374909 "Metabolism of Noradrenaline" is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0042134 name: rRNA primary transcript binding namespace: molecular_function def: "Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript." [GOC:jl] is_a: GO:0019843 ! rRNA binding [Term] id: GO:0042135 name: neurotransmitter catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl] synonym: "neurotransmitter breakdown" EXACT [] synonym: "neurotransmitter catabolism" EXACT [] synonym: "neurotransmitter degradation" EXACT [] is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0042136 name: neurotransmitter biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl] synonym: "neurotransmitter anabolism" EXACT [] synonym: "neurotransmitter biosynthesis" EXACT [] synonym: "neurotransmitter biosynthesis and storage" BROAD [] synonym: "neurotransmitter biosynthetic process and storage" BROAD [] synonym: "neurotransmitter formation" EXACT [] synonym: "neurotransmitter synthesis" EXACT [] xref: Reactome:112311 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1253263 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1280201 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1299071 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1326775 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1352879 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1373085 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1393100 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1417586 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1450677 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1471392 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1483347 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1497036 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1514423 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1526990 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1532725 "Neurotransmitter Clearance In The Synaptic Cleft" xref: Reactome:1539312 "Neurotransmitter Clearance In The Synaptic Cleft" is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0042137 name: sequestering of neurotransmitter namespace: biological_process def: "The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system." [GOC:ai] synonym: "neurotransmitter biosynthesis and storage" RELATED [] synonym: "neurotransmitter biosynthetic process and storage" RELATED [] synonym: "neurotransmitter retention" EXACT [] synonym: "neurotransmitter sequestration" EXACT [] synonym: "neurotransmitter storage" EXACT [] synonym: "retention of neurotransmitter" EXACT [] synonym: "sequestration of neurotransmitter" EXACT [] synonym: "storage of neurotransmitter" EXACT [] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0051235 ! maintenance of location [Term] id: GO:0042138 name: meiotic DNA double-strand break formation namespace: biological_process def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427] is_a: GO:0022402 ! cell cycle process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0042139 name: early meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324] is_a: GO:0007146 ! meiotic recombination nodule assembly [Term] id: GO:0042140 name: late meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324] is_a: GO:0007146 ! meiotic recombination nodule assembly [Term] id: GO:0042141 name: mating pheromone exporter namespace: molecular_function def: "OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating." [GOC:jl] comment: This term was made obsolete because it is too gene product specific. is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0042142 name: heavy metal chelation namespace: biological_process def: "OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein." [GOC:jl, ISBN:0124325653] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0046911 [Term] id: GO:0042144 name: vacuole fusion, non-autophagic namespace: biological_process alt_id: GO:0042145 def: "The fusion of two vacuole membranes to form a single vacuole." [GOC:jl] synonym: "homotypic vacuole fusion" EXACT [] synonym: "homotypic vacuole fusion (non-autophagic)" EXACT [] synonym: "homotypic vacuole fusion, non-autophagic" EXACT [] synonym: "vacuole fusion (non-autophagic)" EXACT [] is_a: GO:0006944 ! cellular membrane fusion is_a: GO:0007033 ! vacuole organization [Term] id: GO:0042147 name: retrograde transport, endosome to Golgi namespace: biological_process def: "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697] synonym: "retrograde (endosome to Golgi) transport" EXACT [] is_a: GO:0016197 ! endosome transport [Term] id: GO:0042148 name: strand invasion namespace: biological_process def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855] synonym: "D-loop biosynthesis" RELATED [] synonym: "D-loop formation" RELATED [] synonym: "displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop formation" RELATED [GOC:mah, GOC:vw] synonym: "Rad51-mediated strand invasion" EXACT [GOC:elh] xref: Reactome:76004 "Strand invasion" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0042149 name: cellular response to glucose starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0042150 name: plasmid recombination namespace: biological_process def: "A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules." [GOC:mlg] subset: gosubset_prok is_a: GO:0006310 ! DNA recombination [Term] id: GO:0042151 name: nematocyst namespace: cellular_component def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [DOI:10.1139/z02-135, GOC:jl] synonym: "cnidocyst" EXACT [] xref: Wikipedia:Cnidocyte is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044448 ! cell cortex part [Term] id: GO:0042152 name: RNA-mediated DNA recombination namespace: biological_process def: "The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele." [GOC:jl, PMID:8380627] subset: gosubset_prok is_a: GO:0006310 ! DNA recombination [Term] id: GO:0042153 name: RPTP-like protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with proteins with similar structure/function to receptor protein tyrosine phosphatases." [GOC:jl] synonym: "receptor protein tyrosine phosphatase-like protein binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042156 name: zinc-mediated transcriptional activator activity namespace: molecular_function def: "OBSOLETE. Initiates or upregulates transcription in the presence of zinc." [GOC:jl] comment: This term was obsoleted because it is defined as a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true [Term] id: GO:0042157 name: lipoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipoprotein metabolism" EXACT [] xref: Reactome:1253385 "Lipoprotein metabolism" xref: Reactome:1253411 "Chylomicron-mediated lipid transport" xref: Reactome:1253590 "HDL-mediated lipid transport" xref: Reactome:1263258 "apolipoprotein(a) + LDL => Lp(a)" xref: Reactome:1280325 "Lipoprotein metabolism" xref: Reactome:1280350 "Chylomicron-mediated lipid transport" xref: Reactome:1280521 "HDL-mediated lipid transport" xref: Reactome:1287795 "apolipoprotein(a) + LDL => Lp(a)" xref: Reactome:1299174 "Lipoprotein metabolism" xref: Reactome:1299190 "Chylomicron-mediated lipid transport" xref: Reactome:1299353 "HDL-mediated lipid transport" xref: Reactome:1326903 "Lipoprotein metabolism" xref: Reactome:1326928 "Chylomicron-mediated lipid transport" xref: Reactome:1327108 "HDL-mediated lipid transport" xref: Reactome:1352995 "Lipoprotein metabolism" xref: Reactome:1353023 "Chylomicron-mediated lipid transport" xref: Reactome:1353204 "HDL-mediated lipid transport" xref: Reactome:1373212 "Chylomicron-mediated lipid transport" xref: Reactome:1373213 "Lipoprotein metabolism" xref: Reactome:1373378 "HDL-mediated lipid transport" xref: Reactome:1393230 "Chylomicron-mediated lipid transport" xref: Reactome:1393231 "Lipoprotein metabolism" xref: Reactome:1393406 "HDL-mediated lipid transport" xref: Reactome:1417699 "Lipoprotein metabolism" xref: Reactome:1417728 "Chylomicron-mediated lipid transport" xref: Reactome:1417899 "HDL-mediated lipid transport" xref: Reactome:1450801 "Lipoprotein metabolism" xref: Reactome:1450825 "Chylomicron-mediated lipid transport" xref: Reactome:1450989 "HDL-mediated lipid transport" xref: Reactome:1471373 "HDL-mediated lipid transport" xref: Reactome:1471374 "Lipoprotein metabolism" xref: Reactome:1483331 "HDL-mediated lipid transport" xref: Reactome:1483332 "Lipoprotein metabolism" xref: Reactome:1497012 "HDL-mediated lipid transport" xref: Reactome:1497013 "Lipoprotein metabolism" xref: Reactome:1514399 "HDL-mediated lipid transport" xref: Reactome:1514400 "Lipoprotein metabolism" xref: Reactome:1536112 "HDL-mediated lipid transport" xref: Reactome:1536113 "Lipoprotein metabolism" xref: Reactome:174800 "Chylomicron-mediated lipid transport" xref: Reactome:174824 "Lipoprotein metabolism" xref: Reactome:176879 "apolipoprotein(a) + LDL => Lp(a)" xref: Reactome:194223 "HDL-mediated lipid transport" is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0042158 name: lipoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipoprotein anabolism" EXACT [] synonym: "lipoprotein biosynthesis" EXACT [] synonym: "lipoprotein formation" EXACT [] synonym: "lipoprotein synthesis" EXACT [] xref: Reactome:1235642 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]" xref: Reactome:1235710 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron" xref: Reactome:1235733 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:1262941 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]" xref: Reactome:1263001 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron" xref: Reactome:1263026 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:1287569 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]" xref: Reactome:1309240 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]" xref: Reactome:1309320 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron" xref: Reactome:1309350 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:1336333 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:1360303 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]" xref: Reactome:1360316 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:1381117 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:1402251 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]" xref: Reactome:1402333 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:1430373 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:174587 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]" xref: Reactome:174741 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron" xref: Reactome:174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0042159 name: lipoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipoprotein breakdown" EXACT [] synonym: "lipoprotein catabolism" EXACT [] synonym: "lipoprotein degradation" EXACT [] xref: Reactome:1235702 "chylomicron remnant + apoE => chylomicron remnant:apoE complex" xref: Reactome:1262993 "chylomicron remnant + apoE => chylomicron remnant:apoE complex" xref: Reactome:1287637 "chylomicron remnant + apoE => chylomicron remnant:apoE complex" xref: Reactome:1309312 "chylomicron remnant + apoE => chylomicron remnant:apoE complex" xref: Reactome:1336321 "chylomicron remnant + apoE => chylomicron remnant:apoE complex" xref: Reactome:1402312 "chylomicron remnant + apoE => chylomicron remnant:apoE complex" xref: Reactome:1430344 "chylomicron remnant + apoE => chylomicron remnant:apoE complex" xref: Reactome:174739 "chylomicron remnant + apoE => chylomicron remnant:apoE complex" is_a: GO:0042157 ! lipoprotein metabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0042160 name: lipoprotein modification namespace: biological_process def: "The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:mah] subset: gosubset_prok is_a: GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0042161 name: lipoprotein oxidation namespace: biological_process def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group." [GOC:mah] subset: gosubset_prok is_a: GO:0042160 ! lipoprotein modification is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0042162 name: telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624] synonym: "telomere binding" EXACT [] synonym: "telomeric repeat binding" EXACT [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0042163 name: interleukin-12 beta subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with the beta subunit of interleukin-12." [GOC:mah] synonym: "CLMFp40 binding" EXACT [] synonym: "IL-12B binding" EXACT [] synonym: "IL-12p40 binding" EXACT [] synonym: "NKSFp40 binding" EXACT [] is_a: GO:0019972 ! interleukin-12 binding [Term] id: GO:0042164 name: interleukin-12 alpha subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with the alpha subunit of interleukin-12." [GOC:mah] synonym: "CLMFp35 binding" EXACT [] synonym: "IL-12A binding" EXACT [] synonym: "IL-12p35 binding" EXACT [] synonym: "NKSFp35 binding" EXACT [] is_a: GO:0019972 ! interleukin-12 binding [Term] id: GO:0042165 name: neurotransmitter binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0042166 name: acetylcholine binding namespace: molecular_function def: "Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043176 ! amine binding [Term] id: GO:0042167 name: heme catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl] subset: gosubset_prok synonym: "haem catabolic process" EXACT [] synonym: "haem catabolism" EXACT [] synonym: "heme breakdown" EXACT [] synonym: "heme catabolism" EXACT [] synonym: "heme degradation" EXACT [] xref: Reactome:1253429 "Heme degradation" xref: Reactome:1280233 "Heme degradation" xref: Reactome:1299093 "Heme degradation" xref: Reactome:1326809 "Heme degradation" xref: Reactome:1352910 "Heme degradation" xref: Reactome:1373116 "Heme degradation" xref: Reactome:1393132 "Heme degradation" xref: Reactome:1417619 "Heme degradation" xref: Reactome:1450715 "Heme degradation" xref: Reactome:1471175 "Heme degradation" xref: Reactome:189483 "Heme degradation" is_a: GO:0006787 ! porphyrin catabolic process is_a: GO:0042168 ! heme metabolic process is_a: GO:0046149 ! pigment catabolic process [Term] id: GO:0042168 name: heme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653] subset: gosubset_prok synonym: "haem metabolic process" EXACT [] synonym: "haem metabolism" EXACT [] synonym: "heme metabolism" EXACT [] is_a: GO:0006778 ! porphyrin metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0042169 name: SH2 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0042170 name: plastid membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044435 ! plastid part relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0042171 name: lysophosphatidic acid acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [PMID:16369050] is_a: GO:0071617 ! lysophospholipid acyltransferase activity [Term] id: GO:0042173 name: regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl] subset: gosubset_prok is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0043937 ! regulation of sporulation is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0030435 ! sporulation resulting in formation of a cellular spore [Term] id: GO:0042174 name: negative regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of sporulation" EXACT [] synonym: "down-regulation of sporulation" EXACT [] synonym: "downregulation of sporulation" EXACT [] synonym: "inhibition of sporulation" NARROW [] is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043939 ! negative regulation of sporulation is_a: GO:0045596 ! negative regulation of cell differentiation relationship: negatively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore [Term] id: GO:0042175 name: nuclear outer membrane-endoplasmic reticulum membrane network namespace: cellular_component def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] synonym: "NE-ER continuum" RELATED [] synonym: "NE-ER network" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah] synonym: "nuclear envelope-ER network" RELATED [] synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah] synonym: "nuclear membrane-ER network" EXACT [GOC:mah] is_a: GO:0016020 ! membrane is_a: GO:0044425 ! membrane part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0042176 name: regulation of protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] subset: gosubset_prok synonym: "regulation of protein breakdown" EXACT [] synonym: "regulation of protein catabolism" EXACT [] synonym: "regulation of protein degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051246 ! regulation of protein metabolic process relationship: regulates GO:0030163 ! protein catabolic process [Term] id: GO:0042177 name: negative regulation of protein catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl, PMID:10207076] subset: gosubset_prok synonym: "down regulation of protein catabolic process" EXACT [] synonym: "down-regulation of protein catabolic process" EXACT [] synonym: "downregulation of protein catabolic process" EXACT [] synonym: "inhibition of protein catabolic process" NARROW [] synonym: "negative regulation of protein breakdown" EXACT [] synonym: "negative regulation of protein catabolism" EXACT [] synonym: "negative regulation of protein degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process relationship: negatively_regulates GO:0030163 ! protein catabolic process [Term] id: GO:0042178 name: xenobiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:jl] subset: gosubset_prok synonym: "xenobiotic breakdown" EXACT [] synonym: "xenobiotic catabolism" EXACT [] synonym: "xenobiotic degradation" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0042179 name: nicotine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] subset: gosubset_prok synonym: "nicotine anabolism" EXACT [] synonym: "nicotine biosynthesis" EXACT [] synonym: "nicotine formation" EXACT [] synonym: "nicotine synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0018933 ! nicotine metabolic process [Term] id: GO:0042180 name: cellular ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153] subset: goslim_pir subset: gosubset_prok synonym: "ketone metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0042181 name: ketone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] subset: gosubset_prok synonym: "ketone anabolism" EXACT [] synonym: "ketone biosynthesis" EXACT [] synonym: "ketone formation" EXACT [] synonym: "ketone synthesis" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0042182 name: ketone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] subset: gosubset_prok synonym: "ketone breakdown" EXACT [] synonym: "ketone catabolism" EXACT [] synonym: "ketone degradation" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0042183 name: formate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "formate breakdown" EXACT [] synonym: "formate catabolism" EXACT [] synonym: "formate degradation" EXACT [] synonym: "formic acid catabolic process" EXACT [] synonym: "formic acid catabolism" EXACT [] is_a: GO:0015942 ! formate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0042184 name: xylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:go_curators] subset: gosubset_prok synonym: "xylene breakdown" EXACT [] synonym: "xylene catabolism" EXACT [] synonym: "xylene degradation" EXACT [] is_a: GO:0018948 ! xylene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0042185 name: m-xylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:go_curators, GOC:jl] subset: gosubset_prok synonym: "m-xylene breakdown" EXACT [] synonym: "m-xylene catabolism" EXACT [] synonym: "m-xylene degradation" EXACT [] synonym: "meta-xylene catabolic process" EXACT [] synonym: "meta-xylene catabolism" EXACT [] xref: MetaCyc:PWY-142 is_a: GO:0018949 ! m-xylene metabolic process is_a: GO:0042184 ! xylene catabolic process [Term] id: GO:0042186 name: o-xylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] subset: gosubset_prok synonym: "o-xylene breakdown" EXACT [] synonym: "o-xylene catabolism" EXACT [] synonym: "o-xylene degradation" EXACT [] synonym: "ortho-xylene catabolic process" EXACT [] synonym: "ortho-xylene catabolism" EXACT [] is_a: GO:0018950 ! o-xylene metabolic process is_a: GO:0042184 ! xylene catabolic process [Term] id: GO:0042187 name: p-xylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:jl] subset: gosubset_prok synonym: "p-xylene breakdown" EXACT [] synonym: "p-xylene catabolism" EXACT [] synonym: "p-xylene degradation" EXACT [] synonym: "para-xylene catabolic process" EXACT [] synonym: "para-xylene catabolism" EXACT [] is_a: GO:0018951 ! p-xylene metabolic process is_a: GO:0042184 ! xylene catabolic process [Term] id: GO:0042188 name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl] subset: gosubset_prok synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown" EXACT [] synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism" EXACT [] synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation" EXACT [] synonym: "DDT catabolic process" EXACT [] synonym: "DDT catabolism" EXACT [] is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process is_a: GO:0046701 ! insecticide catabolic process [Term] id: GO:0042189 name: vanillin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl] subset: gosubset_prok synonym: "vanillic aldehyde biosynthesis" EXACT [] synonym: "vanillic aldehyde biosynthetic process" EXACT [] synonym: "vanillin anabolism" EXACT [] synonym: "vanillin biosynthesis" EXACT [] synonym: "vanillin formation" EXACT [] synonym: "vanillin synthesis" EXACT [] is_a: GO:0018982 ! vanillin metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process [Term] id: GO:0042190 name: vanillin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl] subset: gosubset_prok synonym: "vanillic aldehyde catabolic process" EXACT [] synonym: "vanillic aldehyde catabolism" EXACT [] synonym: "vanillin breakdown" EXACT [] synonym: "vanillin catabolism" EXACT [] synonym: "vanillin degradation" EXACT [] is_a: GO:0018982 ! vanillin metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046185 ! aldehyde catabolic process [Term] id: GO:0042191 name: methylmercury metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species." [GOC:ai] subset: gosubset_prok synonym: "methylmercury metabolism" EXACT [] is_a: GO:0018941 ! organomercury metabolic process [Term] id: GO:0042192 name: methylmercury biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai] subset: gosubset_prok synonym: "methylmercury anabolism" EXACT [] synonym: "methylmercury biosynthesis" EXACT [] synonym: "methylmercury formation" EXACT [] synonym: "methylmercury synthesis" EXACT [] is_a: GO:0042191 ! methylmercury metabolic process is_a: GO:0046414 ! organomercury biosynthetic process [Term] id: GO:0042193 name: methylmercury catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai] subset: gosubset_prok synonym: "methylmercury breakdown" EXACT [] synonym: "methylmercury catabolism" EXACT [] synonym: "methylmercury degradation" EXACT [] is_a: GO:0042191 ! methylmercury metabolic process is_a: GO:0046413 ! organomercury catabolic process [Term] id: GO:0042194 name: quinate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid." [GOC:go_curators] subset: gosubset_prok synonym: "quinate anabolism" EXACT [] synonym: "quinate biosynthesis" EXACT [] synonym: "quinate formation" EXACT [] synonym: "quinate synthesis" EXACT [] synonym: "quinic acid biosynthesis" EXACT [] synonym: "quinic acid biosynthetic process" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019630 ! quinate metabolic process [Term] id: GO:0042195 name: aerobic gallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen." [GOC:jl] subset: gosubset_prok synonym: "aerobic gallate breakdown" EXACT [] synonym: "aerobic gallate catabolism" EXACT [] synonym: "aerobic gallate degradation" EXACT [] synonym: "aerobic gallic acid catabolic process" EXACT [] synonym: "aerobic gallic acid catabolism" EXACT [] is_a: GO:0019396 ! gallate catabolic process [Term] id: GO:0042196 name: chlorinated hydrocarbon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai] subset: gosubset_prok synonym: "chlorinated hydrocarbon metabolism" EXACT [] is_a: GO:0042197 ! halogenated hydrocarbon metabolic process [Term] id: GO:0042197 name: halogenated hydrocarbon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine." [GOC:ai] subset: gosubset_prok synonym: "halogenated hydrocarbon metabolism" EXACT [] xref: Reactome:1230016 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:1257793 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:1283421 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:1303848 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:1331308 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:1356226 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:1377227 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:1397459 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:1423463 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0042198 name: nylon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [SP_KW:KW-0549] subset: gosubset_prok synonym: "nylon metabolism" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0042199 name: cyanuric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [http://umbbd.ahc.umn.edu/cya/cya_map.html, UM-BBD_pathwayID:cya] subset: gosubset_prok synonym: "cyanuric acid metabolism" EXACT [] is_a: GO:0018965 ! s-triazine compound metabolic process [Term] id: GO:0042200 name: cyanuric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides." [http://umbbd.ahc.umn.edu/cya/cya_map.html, UM-BBD_pathwayID:cya] subset: gosubset_prok synonym: "cyanuric acid breakdown" EXACT [] synonym: "cyanuric acid catabolism" EXACT [] synonym: "cyanuric acid degradation" EXACT [] xref: UM-BBD_pathwayID:cya is_a: GO:0042199 ! cyanuric acid metabolic process is_a: GO:0042204 ! s-triazine compound catabolic process [Term] id: GO:0042201 name: N-cyclopropylmelamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [http://umbbd.ahc.umn.edu/cpm/cpm_map.html, UM-BBD_pathwayID:cpm] subset: gosubset_prok synonym: "cyromazine metabolic process" EXACT [] synonym: "cyromazine metabolism" EXACT [] synonym: "N-cyclopropylmelamine metabolism" EXACT [] is_a: GO:0018965 ! s-triazine compound metabolic process [Term] id: GO:0042202 name: N-cyclopropylmelamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide." [http://umbbd.ahc.umn.edu/cpm/cpm_map.html, UM-BBD_pathwayID:cpm] subset: gosubset_prok synonym: "cyromazine catabolic process" EXACT [] synonym: "cyromazine catabolism" EXACT [] synonym: "N-cyclopropylmelamine breakdown" EXACT [] synonym: "N-cyclopropylmelamine catabolism" EXACT [] synonym: "N-cyclopropylmelamine degradation" EXACT [] xref: UM-BBD_pathwayID:cpm is_a: GO:0042201 ! N-cyclopropylmelamine metabolic process is_a: GO:0042204 ! s-triazine compound catabolic process [Term] id: GO:0042203 name: toluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:go_curators] subset: gosubset_prok synonym: "toluene breakdown" EXACT [] synonym: "toluene catabolism" EXACT [] synonym: "toluene degradation" EXACT [] is_a: GO:0018970 ! toluene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0042204 name: s-triazine compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [http://umbbd.ahc.umn.edu/tria/tria_map.html, UM-BBD_pathwayID:tria] subset: gosubset_prok synonym: "s-triazine compound breakdown" EXACT [] synonym: "s-triazine compound catabolism" EXACT [] synonym: "s-triazine compound degradation" EXACT [] xref: UM-BBD_pathwayID:tria is_a: GO:0018965 ! s-triazine compound metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0042205 name: chlorinated hydrocarbon catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai] subset: gosubset_prok synonym: "chlorinated hydrocarbon breakdown" EXACT [] synonym: "chlorinated hydrocarbon catabolism" EXACT [] synonym: "chlorinated hydrocarbon degradation" EXACT [] is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042206 ! halogenated hydrocarbon catabolic process [Term] id: GO:0042206 name: halogenated hydrocarbon catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it." [GOC:ai] subset: gosubset_prok synonym: "halogenated hydrocarbon breakdown" EXACT [] synonym: "halogenated hydrocarbon catabolism" EXACT [] synonym: "halogenated hydrocarbon degradation" EXACT [] is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042197 ! halogenated hydrocarbon metabolic process [Term] id: GO:0042207 name: styrene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:jl] subset: gosubset_prok synonym: "styrene breakdown" EXACT [] synonym: "styrene catabolism" EXACT [] synonym: "styrene degradation" EXACT [] xref: UM-BBD_pathwayID:sty is_a: GO:0018966 ! styrene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043451 ! alkene catabolic process [Term] id: GO:0042208 name: propylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining." [GOC:jl] subset: gosubset_prok synonym: "propylene breakdown" EXACT [] synonym: "propylene catabolism" EXACT [] synonym: "propylene degradation" EXACT [] xref: UM-BBD_pathwayID:pro is_a: GO:0018964 ! propylene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043451 ! alkene catabolic process [Term] id: GO:0042209 name: orcinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:jl] subset: gosubset_prok synonym: "orcin catabolic process" EXACT [] synonym: "orcin catabolism" EXACT [] synonym: "orcinol breakdown" EXACT [] synonym: "orcinol catabolism" EXACT [] synonym: "orcinol degradation" EXACT [] xref: UM-BBD_pathwayID:orc is_a: GO:0018940 ! orcinol metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0034313 ! diol catabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0042210 name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter." [GOC:jl] subset: gosubset_prok synonym: "catabolic process of octamethylcyclotetrasiloxane to DMSD" EXACT [] synonym: "catabolism of octamethylcyclotetrasiloxane to DMSD" EXACT [] synonym: "octamethylcyclotetrasiloxane breakdown to dimethylsilanediol" EXACT [] synonym: "octamethylcyclotetrasiloxane degradation to dimethylsilanediol" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0018947 ! anaerobic organosilicon metabolic process is_a: GO:0046454 ! dimethylsilanediol metabolic process is_a: GO:0046517 ! octamethylcyclotetrasiloxane catabolic process [Term] id: GO:0042211 name: dimethylsilanediol catabolic process namespace: biological_process def: "The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:jl] subset: gosubset_prok synonym: "catabolic process of DMSD" EXACT [] synonym: "catabolism of DMSD" EXACT [] synonym: "degradation of dimethylsilanediol" EXACT [] synonym: "dimethylsilanediol breakdown" EXACT [] synonym: "dimethylsilanediol catabolism" EXACT [] synonym: "dimethylsilanediol degradation" EXACT [] is_a: GO:0018946 ! aerobic organosilicon metabolic process is_a: GO:0046454 ! dimethylsilanediol metabolic process is_a: GO:0046455 ! organosilicon catabolic process [Term] id: GO:0042212 name: cresol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [http://umbbd.ahc.umn.edu/mcr/mcr_map.html, UM-BBD_pathwayID:mcr] subset: gosubset_prok synonym: "cresol metabolism" EXACT [] synonym: "hydroxytoluene metabolic process" EXACT [] synonym: "hydroxytoluene metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0042213 name: m-cresol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:jl] subset: gosubset_prok synonym: "3-hydroxytoluene catabolic process" EXACT [] synonym: "3-hydroxytoluene catabolism" EXACT [] synonym: "m-cresol breakdown" EXACT [] synonym: "m-cresol catabolism" EXACT [] synonym: "m-cresol degradation" EXACT [] synonym: "meta-cresol catabolic process" EXACT [] synonym: "meta-cresol catabolism" EXACT [] xref: MetaCyc:M-CRESOL-DEGRADATION-PWY xref: UM-BBD_pathwayID:mcr is_a: GO:0018925 ! m-cresol metabolic process is_a: GO:0046199 ! cresol catabolic process [Term] id: GO:0042214 name: terpene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups." [CHEBI:35186, GOC:curators] subset: gosubset_prok synonym: "terpene metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0042215 name: anaerobic phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [CHEBI:33853, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "anaerobic phenol-containing compound metabolism" EXACT [GOC:curators] xref: UM-BBD_pathwayID:phe is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0042216 name: phenanthrene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:jl] subset: gosubset_prok synonym: "phenanthrene breakdown" EXACT [] synonym: "phenanthrene catabolism" EXACT [] synonym: "phenanthrene degradation" EXACT [] xref: UM-BBD_pathwayID:phe is_a: GO:0018955 ! phenanthrene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0042217 name: 1-aminocyclopropane-1-carboxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators] subset: gosubset_prok synonym: "1-aminocyclopropane-1-carboxylate breakdown" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate catabolism" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0042218 name: 1-aminocyclopropane-1-carboxylate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators] subset: gosubset_prok synonym: "1-aminocyclopropane-1-carboxylate anabolism" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate biosynthesis" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate formation" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0042219 name: cellular modified amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] subset: gosubset_prok synonym: "amino acid derivative catabolic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative breakdown" EXACT [] synonym: "cellular amino acid derivative catabolic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative catabolism" EXACT [] synonym: "cellular amino acid derivative degradation" EXACT [] synonym: "cellular modified amino acid breakdown" EXACT [GOC:mah] synonym: "cellular modified amino acid catabolism" EXACT [GOC:mah] synonym: "cellular modified amino acid degradation" EXACT [GOC:mah] synonym: "modified amino acid catabolic process" EXACT [GOC:mah] synonym: "modified amino acid catabolism" EXACT [GOC:mah] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0009063 ! cellular amino acid catabolic process [Term] id: GO:0042220 name: response to cocaine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [CHEBI:27958, GOC:ef, GOC:jl] is_a: GO:0014073 ! response to tropane is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0042221 name: response to chemical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: goslim_candida subset: goslim_yeast subset: gosubset_prok subset: high_level_annotation_qc synonym: "response to chemical substance" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0042222 name: interleukin-1 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "IL-1 biosynthesis" EXACT [] synonym: "IL-1 biosynthetic process" EXACT [] synonym: "interleukin-1 anabolism" EXACT [] synonym: "interleukin-1 biosynthesis" EXACT [] synonym: "interleukin-1 formation" EXACT [] synonym: "interleukin-1 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032612 ! interleukin-1 production [Term] id: GO:0042223 name: interleukin-3 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] synonym: "IL-3 biosynthesis" EXACT [] synonym: "IL-3 biosynthetic process" EXACT [] synonym: "interleukin-3 anabolism" EXACT [] synonym: "interleukin-3 biosynthesis" EXACT [] synonym: "interleukin-3 formation" EXACT [] synonym: "interleukin-3 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032632 ! interleukin-3 production [Term] id: GO:0042225 name: interleukin-5 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] synonym: "IL-5 biosynthesis" EXACT [] synonym: "IL-5 biosynthetic process" EXACT [] synonym: "interleukin-5 anabolism" EXACT [] synonym: "interleukin-5 biosynthesis" EXACT [] synonym: "interleukin-5 formation" EXACT [] synonym: "interleukin-5 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032634 ! interleukin-5 production [Term] id: GO:0042226 name: interleukin-6 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] synonym: "IL-6 biosynthesis" EXACT [] synonym: "IL-6 biosynthetic process" EXACT [] synonym: "interleukin-6 anabolism" EXACT [] synonym: "interleukin-6 biosynthesis" EXACT [] synonym: "interleukin-6 formation" EXACT [] synonym: "interleukin-6 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032635 ! interleukin-6 production [Term] id: GO:0042227 name: interleukin-7 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] synonym: "IL-7 biosynthesis" EXACT [] synonym: "IL-7 biosynthetic process" EXACT [] synonym: "interleukin-7 anabolism" EXACT [] synonym: "interleukin-7 biosynthesis" EXACT [] synonym: "interleukin-7 formation" EXACT [] synonym: "interleukin-7 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032636 ! interleukin-7 production [Term] id: GO:0042228 name: interleukin-8 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] synonym: "IL-8 biosynthesis" EXACT [] synonym: "IL-8 biosynthetic process" EXACT [] synonym: "interleukin-8 anabolism" EXACT [] synonym: "interleukin-8 biosynthesis" EXACT [] synonym: "interleukin-8 formation" EXACT [] synonym: "interleukin-8 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032637 ! interleukin-8 production [Term] id: GO:0042229 name: interleukin-9 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] synonym: "IL-9 biosynthesis" EXACT [] synonym: "IL-9 biosynthetic process" EXACT [] synonym: "interleukin-9 anabolism" EXACT [] synonym: "interleukin-9 biosynthesis" EXACT [] synonym: "interleukin-9 formation" EXACT [] synonym: "interleukin-9 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032638 ! interleukin-9 production [Term] id: GO:0042230 name: interleukin-11 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] synonym: "IL-11 biosynthesis" EXACT [] synonym: "IL-11 biosynthetic process" EXACT [] synonym: "interleukin-11 anabolism" EXACT [] synonym: "interleukin-11 biosynthesis" EXACT [] synonym: "interleukin-11 formation" EXACT [] synonym: "interleukin-11 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032614 ! interleukin-11 production [Term] id: GO:0042231 name: interleukin-13 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] synonym: "IL-13 biosynthesis" EXACT [] synonym: "IL-13 biosynthetic process" EXACT [] synonym: "interleukin-13 anabolism" EXACT [] synonym: "interleukin-13 biosynthesis" EXACT [] synonym: "interleukin-13 formation" EXACT [] synonym: "interleukin-13 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032616 ! interleukin-13 production [Term] id: GO:0042232 name: interleukin-14 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] synonym: "IL-14 biosynthesis" EXACT [] synonym: "IL-14 biosynthetic process" EXACT [] synonym: "interleukin-14 anabolism" EXACT [] synonym: "interleukin-14 biosynthesis" EXACT [] synonym: "interleukin-14 formation" EXACT [] synonym: "interleukin-14 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032617 ! interleukin-14 production [Term] id: GO:0042233 name: interleukin-15 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] synonym: "IL-15 biosynthesis" EXACT [] synonym: "IL-15 biosynthetic process" EXACT [] synonym: "interleukin-15 anabolism" EXACT [] synonym: "interleukin-15 biosynthesis" EXACT [] synonym: "interleukin-15 formation" EXACT [] synonym: "interleukin-15 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032618 ! interleukin-15 production [Term] id: GO:0042234 name: interleukin-16 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] synonym: "IL-16 biosynthesis" EXACT [] synonym: "IL-16 biosynthetic process" EXACT [] synonym: "interleukin-16 anabolism" EXACT [] synonym: "interleukin-16 biosynthesis" EXACT [] synonym: "interleukin-16 formation" EXACT [] synonym: "interleukin-16 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032619 ! interleukin-16 production [Term] id: GO:0042235 name: interleukin-17 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators] synonym: "IL-17 biosynthesis" EXACT [] synonym: "IL-17 biosynthetic process" EXACT [] synonym: "interleukin-17 anabolism" EXACT [] synonym: "interleukin-17 biosynthesis" EXACT [] synonym: "interleukin-17 formation" EXACT [] synonym: "interleukin-17 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032620 ! interleukin-17 production [Term] id: GO:0042236 name: interleukin-19 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] synonym: "IL-19 biosynthesis" EXACT [] synonym: "IL-19 biosynthetic process" EXACT [] synonym: "interleukin-19 anabolism" EXACT [] synonym: "interleukin-19 biosynthesis" EXACT [] synonym: "interleukin-19 formation" EXACT [] synonym: "interleukin-19 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032622 ! interleukin-19 production [Term] id: GO:0042237 name: interleukin-20 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] synonym: "IL-20 biosynthesis" EXACT [] synonym: "IL-20 biosynthetic process" EXACT [] synonym: "interleukin-20 anabolism" EXACT [] synonym: "interleukin-20 biosynthesis" EXACT [] synonym: "interleukin-20 formation" EXACT [] synonym: "interleukin-20 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032624 ! interleukin-20 production [Term] id: GO:0042238 name: interleukin-21 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] synonym: "IL-21 biosynthesis" EXACT [] synonym: "IL-21 biosynthetic process" EXACT [] synonym: "interleukin-21 anabolism" EXACT [] synonym: "interleukin-21 biosynthesis" EXACT [] synonym: "interleukin-21 formation" EXACT [] synonym: "interleukin-21 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032625 ! interleukin-21 production [Term] id: GO:0042239 name: interleukin-22 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] synonym: "IL-22 biosynthesis" EXACT [] synonym: "IL-22 biosynthetic process" EXACT [] synonym: "interleukin-22 anabolism" EXACT [] synonym: "interleukin-22 biosynthesis" EXACT [] synonym: "interleukin-22 formation" EXACT [] synonym: "interleukin-22 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032626 ! interleukin-22 production [Term] id: GO:0042240 name: interleukin-23 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] synonym: "IL-23 biosynthesis" EXACT [] synonym: "IL-23 biosynthetic process" EXACT [] synonym: "interleukin-23 anabolism" EXACT [] synonym: "interleukin-23 biosynthesis" EXACT [] synonym: "interleukin-23 formation" EXACT [] synonym: "interleukin-23 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032627 ! interleukin-23 production [Term] id: GO:0042241 name: interleukin-18 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] synonym: "IL-18 biosynthesis" EXACT [] synonym: "IL-18 biosynthetic process" EXACT [] synonym: "interleukin-18 anabolism" EXACT [] synonym: "interleukin-18 biosynthesis" EXACT [] synonym: "interleukin-18 formation" EXACT [] synonym: "interleukin-18 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032621 ! interleukin-18 production [Term] id: GO:0042242 name: cobyrinic acid a,c-diamide synthase activity namespace: molecular_function def: "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide." [PMID:2172209] comment: Note that this enzyme does not have an EC number yet, as its activity has not been proven experimentally. May need to be moved in the future. subset: gosubset_prok synonym: "CobB" NARROW [] is_a: GO:0004359 ! glutaminase activity [Term] id: GO:0042243 name: asexual spore wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of mitosis. Examples of this process are found in Bacterial species." [GOC:mah] subset: gosubset_prok synonym: "asexual spore wall formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0042244 ! spore wall assembly is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030436 ! asexual sporulation [Term] id: GO:0042244 name: spore wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] subset: gosubset_prok synonym: "spore coat biosynthesis" EXACT [] synonym: "spore coat biosynthetic process" EXACT [] synonym: "spore wall formation" EXACT [] is_a: GO:0007047 ! cellular cell wall organization is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0070726 ! cell wall assembly relationship: part_of GO:0070590 ! spore wall biogenesis [Term] id: GO:0042245 name: RNA repair namespace: biological_process def: "Any process that results in the repair of damaged RNA." [PMID:11000254, PMID:11070075, SP_KW:KW-0692] subset: gosubset_prok is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0042246 name: tissue regeneration namespace: biological_process def: "The regrowth of lost or destroyed tissues." [GOC:curators] is_a: GO:0009888 ! tissue development is_a: GO:0031099 ! regeneration is_a: GO:0048589 ! developmental growth relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0042247 name: establishment of planar polarity of follicular epithelium namespace: biological_process def: "Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium [Term] id: GO:0042248 name: maintenance of polarity of follicular epithelium namespace: biological_process def: "The maintenance of an established polarized follicular epithelial sheet." [GOC:bf] is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium [Term] id: GO:0042249 name: establishment of planar polarity of embryonic epithelium namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity [Term] id: GO:0042250 name: maintenance of polarity of embryonic epithelium namespace: biological_process def: "The maintenance of an established polarized embryonic epithelial sheet." [GOC:jl] is_a: GO:0016332 ! establishment or maintenance of polarity of embryonic epithelium [Term] id: GO:0042251 name: maintenance of polarity of larval imaginal disc epithelium namespace: biological_process def: "The maintenance of an established polarized larval imaginal disc epithelium." [GOC:jl] is_a: GO:0016336 ! establishment or maintenance of polarity of larval imaginal disc epithelium [Term] id: GO:0042252 name: establishment of planar polarity of larval imaginal disc epithelium namespace: biological_process def: "Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates." [GOC:jl] is_a: GO:0001736 ! establishment of planar polarity [Term] id: GO:0042253 name: granulocyte macrophage colony-stimulating factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "GM-CSF biosynthesis" EXACT [] synonym: "GM-CSF biosynthetic process" EXACT [] synonym: "GMC-SF biosynthesis" EXACT [] synonym: "GMC-SF biosynthetic process" EXACT [] synonym: "granulocyte macrophage colony stimulating factor biosynthetic process" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor anabolism" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor formation" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process alt_id: GO:0007046 def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "ribosomal chaperone activity" RELATED [] synonym: "ribosome biogenesis and assembly" EXACT [] xref: Wikipedia:Ribosome_biogenesis is_a: GO:0022613 ! ribonucleoprotein complex biogenesis [Term] id: GO:0042255 name: ribosome assembly namespace: biological_process alt_id: GO:0042257 def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma] subset: gosubset_prok synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw] is_a: GO:0022618 ! ribonucleoprotein complex assembly is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0042256 name: mature ribosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma] subset: gosubset_prok is_a: GO:0042255 ! ribosome assembly [Term] id: GO:0042258 name: molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide namespace: biological_process def: "The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide." [PDB:1EU1, PMID:8658132, RESID:AA0319] subset: gosubset_prok xref: RESID:AA0319 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0042259 name: peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine namespace: biological_process def: "The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12." [GOC:jsg, RESID:AA0320] subset: gosubset_prok synonym: "peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine" EXACT [] synonym: "peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine" EXACT [] synonym: "peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine" EXACT [] xref: RESID:AA0320 is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0042262 name: DNA protection namespace: biological_process def: "Any process in which DNA is protected from damage by, for example, oxidative stress." [GOC:jl] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process is_a: GO:0031668 ! cellular response to extracellular stimulus is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0042263 name: neuropeptide F receptor activity namespace: molecular_function def: "Combining with neuropeptide F, an invertebrate neuropeptide thought to play a role in neuroregulation, to initiate a change in cell activity. In many species, neuropeptide F is between 36 and 39 amino acid residues terminating in a phenylalaninamide residue." [GOC:ma] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0042264 name: peptidyl-aspartic acid hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid." [GOC:mah] subset: gosubset_prok synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD [] is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0042265 name: peptidyl-asparagine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine." [GOC:mah] subset: gosubset_prok synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD [] is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0042267 name: natural killer cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "killer activity" RELATED [] synonym: "natural killer cell mediated cell death" EXACT [] synonym: "natural killer cell mediated cell killing" EXACT [] synonym: "natural killer cell mediated cytolysis" RELATED [] synonym: "natural killer-cell mediated cytolysis" RELATED [] synonym: "NK cell mediated cell death" EXACT [] synonym: "NK cell mediated cell killing" EXACT [] synonym: "NK cell mediated cytolysis" RELATED [] synonym: "NK cell mediated cytotoxicity" EXACT [] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0006917 ! induction of apoptosis [Term] id: GO:0042268 name: regulation of cytolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl] subset: gosubset_prok is_a: GO:0010941 ! regulation of cell death relationship: regulates GO:0019835 ! cytolysis [Term] id: GO:0042269 name: regulation of natural killer cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of natural killer cell mediated cell death" EXACT [] synonym: "regulation of natural killer cell mediated cell killing" EXACT [] synonym: "regulation of natural killer cell mediated cytolysis" RELATED [] synonym: "regulation of natural killer-cell mediated cytolysis" RELATED [] synonym: "regulation of NK cell mediated cell death" EXACT [] synonym: "regulation of NK cell mediated cell killing" EXACT [] synonym: "regulation of NK cell mediated cytolysis" RELATED [] synonym: "regulation of NK cell mediated cytotoxicity" RELATED [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity relationship: regulates GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0042270 name: protection from natural killer cell mediated cytotoxicity namespace: biological_process def: "The process of protecting a cell from natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "protection from natural killer cell mediated cell death" EXACT [] synonym: "protection from natural killer cell mediated cell killing" EXACT [] synonym: "protection from natural killer cell mediated cytolysis" RELATED [] synonym: "protection from NK cell mediated cell death" EXACT [] synonym: "protection from NK cell mediated cell killing" EXACT [] synonym: "protection from NK cell mediated cytolysis" RELATED [] synonym: "protection from NK cell mediated cytotoxicity" EXACT [] is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity [Term] id: GO:0042271 name: susceptibility to natural killer cell mediated cytotoxicity namespace: biological_process def: "The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity. synonym: "susceptibility to natural killer cell mediated cell death" EXACT [] synonym: "susceptibility to natural killer cell mediated cell killing" EXACT [] synonym: "susceptibility to natural killer cell mediated cytolysis" RELATED [] synonym: "susceptibility to NK cell mediated cell death" EXACT [] synonym: "susceptibility to NK cell mediated cell killing" EXACT [] synonym: "susceptibility to NK cell mediated cytolysis" EXACT [] synonym: "susceptibility to NK cell mediated cytotoxicity" EXACT [] is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity [Term] id: GO:0042272 name: nuclear RNA export factor complex namespace: cellular_component def: "A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [PMID:11780633] synonym: "Mex67-Mtr2 complex" EXACT [] synonym: "NXF1-NXT1 complex" EXACT [] synonym: "TAP-p15 complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0042273 name: ribosomal large subunit biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] synonym: "ribosomal large subunit biogenesis and assembly" EXACT [] is_a: GO:0022613 ! ribonucleoprotein complex biogenesis relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0042274 name: ribosomal small subunit biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] synonym: "ribosomal small subunit biogenesis and assembly" EXACT [] is_a: GO:0022613 ! ribonucleoprotein complex biogenesis relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0042275 name: error-free postreplication DNA repair namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions and but does not increase the endogenous mutation rate." [GOC:elh, GOC:jl, PMID:11459630] comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication. subset: gosubset_prok synonym: "error-free PRR" EXACT [] synonym: "error-free replication restart" RELATED [] is_a: GO:0006301 ! postreplication repair [Term] id: GO:0042276 name: error-prone translesion synthesis namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998] subset: gosubset_prok synonym: "error-prone postreplication DNA repair" RELATED [GOC:elh] synonym: "mutagenic postreplication DNA repair" RELATED [GOC:elh] synonym: "mutagenic PRR" EXACT [] is_a: GO:0019985 ! translesion synthesis [Term] id: GO:0042277 name: peptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0042278 name: purine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "purine metabolic process" BROAD [] synonym: "purine metabolism" BROAD [] synonym: "purine nucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0042279 name: nitrite reductase (cytochrome, ammonia-forming) activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+." [EC:1.7.2.2] subset: gosubset_prok synonym: "ammonia:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.2] synonym: "cytochrome c nitrite reductase activity" EXACT [] synonym: "cytochrome c552 activity" NARROW [EC:1.7.2.2] synonym: "multiheme nitrite reductase activity" EXACT [] synonym: "nitrite reductase (cytochrome; ammonia-forming)" EXACT [EC:1.7.2.2] xref: EC:1.7.2.2 xref: MetaCyc:1.7.2.2-RXN xref: Wikipedia:Nitrite_reductase_(cytochrome;_ammonia-forming) is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: GO:0042280 name: cell surface antigen activity, host-interacting namespace: molecular_function def: "OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition." [GOC:mb] comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true consider: GO:0044403 consider: GO:0046789 [Term] id: GO:0042281 name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5470] synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: EC:2.4.1.- xref: MetaCyc:RXN-5470 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0042282 name: hydroxymethylglutaryl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH." [EC:1.1.1.88, RHEA:14836] subset: gosubset_prok synonym: "(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.1.1.88] synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase activity" EXACT [EC:1.1.1.88] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.88] synonym: "beta-hydroxy-beta-methylglutaryl CoA-reductase activity" BROAD [EC:1.1.1.88] synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.88] synonym: "hydroxymethylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] synonym: "hydroxymethylglutaryl-CoA reductase (NADH) activity" EXACT [EC:1.1.1.88] xref: EC:1.1.1.88 xref: KEGG:R02081 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN xref: RHEA:14836 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0042283 name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5471, PMID:12480927] synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: EC:2.4.1.- xref: MetaCyc:RXN-5471 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0042284 name: sphingolipid delta-4 desaturase activity namespace: molecular_function def: "Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid." [PMID:12417141] synonym: "delta-4 sphingolipid desaturase activity" EXACT [] xref: Reactome:10375 "sphingolipid delta-4 desaturase activity" is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0042285 name: xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0042286 name: glutamate-1-semialdehyde 2,1-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate." [EC:5.4.3.8, RHEA:14268] subset: gosubset_prok synonym: "(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity" EXACT [EC:5.4.3.8] synonym: "glutamate-1-semialdehyde aminotransferase activity" EXACT [EC:5.4.3.8] xref: EC:5.4.3.8 xref: KEGG:R02272 xref: MetaCyc:GSAAMINOTRANS-RXN xref: RHEA:14268 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0042287 name: MHC protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "major histocompatibility complex binding" EXACT [] synonym: "major histocompatibility complex ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0042288 name: MHC class I protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "major histocompatibility complex class I binding" EXACT [] synonym: "major histocompatibility complex class I ligand" NARROW [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0042287 ! MHC protein binding [Term] id: GO:0042289 name: MHC class II protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "major histocompatibility complex class II binding" EXACT [] synonym: "major histocompatibility complex class II ligand" NARROW [] is_a: GO:0042287 ! MHC protein binding [Term] id: GO:0042290 name: URM1 hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. is_obsolete: true consider: GO:0019783 [Term] id: GO:0042291 name: Hub1 hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. is_obsolete: true consider: GO:0019783 [Term] id: GO:0042292 name: URM1 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0042293 name: Hub1 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0042294 name: URM1 conjugating enzyme activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein URM1 to other proteins or other substrate molecules." [GOC:mah, PMID:12826404] is_a: GO:0019787 ! small conjugating protein ligase activity [Term] id: GO:0042296 name: ISG15 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins." [GOC:mah, PMID:12826404] synonym: "ISG15 conjugating enzyme activity" EXACT [] is_a: GO:0019787 ! small conjugating protein ligase activity [Term] id: GO:0042297 name: vocal learning namespace: biological_process def: "A behavioral process whose outcome is a relatively long-lasting adaptive behavioral change whereby an organism modifies innate vocalizations to imitate or create new sounds." [PMID:16418265, PMID:17035521] xref: Wikipedia:Vocal_learning is_a: GO:0007612 ! learning is_a: GO:0031223 ! auditory behavior [Term] id: GO:0042299 name: lupeol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol." [MetaCyc:RXN-111, PMID:9883589] synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99.- xref: MetaCyc:RXN-111 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0042300 name: beta-amyrin synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin." [PMID:9746369] synonym: "oxidosqualene:beta-amyrin cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99.- xref: MetaCyc:RXN-7570 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0042301 name: phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphate." [GOC:jl] subset: gosubset_prok is_a: GO:0043168 ! anion binding [Term] id: GO:0042302 name: structural constituent of cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0042303 name: molting cycle namespace: biological_process def: "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0042304 name: regulation of fatty acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl] subset: gosubset_prok synonym: "regulation of fatty acid anabolism" EXACT [] synonym: "regulation of fatty acid biosynthesis" EXACT [] synonym: "regulation of fatty acid formation" EXACT [] synonym: "regulation of fatty acid synthesis" EXACT [] xref: Reactome:1253338 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1280276 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1299130 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1326854 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1352946 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1373150 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1393166 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1417655 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1471193 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1483189 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1496881 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1514274 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1521140 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1526895 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:1532624 "AMPK inhibits chREBP transcriptional activation activity" xref: Reactome:163680 "AMPK inhibits chREBP transcriptional activation activity" is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0042305 name: specification of segmental identity, mandibular segment namespace: biological_process def: "The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'mandibular segment ; FBbt:00000012'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0042306 name: regulation of protein import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] synonym: "regulation of protein import into cell nucleus" EXACT [] synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of protein-nucleus import" EXACT [] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport relationship: regulates GO:0006606 ! protein import into nucleus [Term] id: GO:0042307 name: positive regulation of protein import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl] synonym: "activation of protein import into nucleus" NARROW [] synonym: "positive regulation of protein import into cell nucleus" EXACT [] synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of protein-nucleus import" EXACT [] synonym: "stimulation of protein import into nucleus" NARROW [] synonym: "up regulation of protein import into nucleus" EXACT [] synonym: "up-regulation of protein import into nucleus" EXACT [] synonym: "upregulation of protein import into nucleus" EXACT [] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0090316 ! positive regulation of intracellular protein transport relationship: positively_regulates GO:0006606 ! protein import into nucleus [Term] id: GO:0042308 name: negative regulation of protein import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl] synonym: "down regulation of protein import into nucleus" EXACT [] synonym: "down-regulation of protein import into nucleus" EXACT [] synonym: "downregulation of protein import into nucleus" EXACT [] synonym: "inhibition of protein import into nucleus" NARROW [] synonym: "negative regulation of protein import into cell nucleus" EXACT [] synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of protein-nucleus import" EXACT [] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0090317 ! negative regulation of intracellular protein transport relationship: negatively_regulates GO:0006606 ! protein import into nucleus [Term] id: GO:0042309 name: homoiothermy namespace: biological_process def: "Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment." [ISBN:0192801023] synonym: "antifreeze activity" RELATED [] synonym: "ice nucleation activity" RELATED [] synonym: "ice nucleation inhibitor activity" RELATED [] is_a: GO:0001659 ! temperature homeostasis [Term] id: GO:0042310 name: vasoconstriction namespace: biological_process def: "A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure." [ISBN:0192800752] synonym: "negative regulation of blood vessel size" EXACT [] xref: Wikipedia:Vasoconstriction is_a: GO:0050880 ! regulation of blood vessel size [Term] id: GO:0042311 name: vasodilation namespace: biological_process def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure." [ISBN:0192800981] synonym: "positive regulation of blood vessel size" EXACT [] synonym: "vasodilatation" EXACT [] xref: Wikipedia:Vasodilation is_a: GO:0050880 ! regulation of blood vessel size [Term] id: GO:0042312 name: regulation of vasodilation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels." [GOC:jl] synonym: "regulation of vasodilatation" EXACT [] is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0042311 ! vasodilation [Term] id: GO:0042313 name: protein kinase C deactivation namespace: biological_process def: "Any process resulting in the inhibition or termination of the activity of protein kinase C." [GOC:bf] synonym: "PKC deactivation" EXACT [] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway [Term] id: GO:0042314 name: bacteriochlorophyll binding namespace: molecular_function def: "Interacting selectively and non-covalently with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants." [ISBN:0192800981] subset: gosubset_prok is_a: GO:0016168 ! chlorophyll binding [Term] id: GO:0042315 name: cytosol nonspecific dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [EC:3.4.13.18] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "cytosol non-specific dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "diglycinase activity" EXACT [EC:3.4.13.18] synonym: "Gly-Leu hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-glycine dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "glycyl-L-leucine dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-L-leucine hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-L-leucine peptidase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-leucine dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "glycylleucine dipeptide hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycylleucine hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycylleucine peptidase activity" EXACT [EC:3.4.13.18] synonym: "human cytosolic non-specific dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "iminodipeptidase activity" EXACT [EC:3.4.13.18] synonym: "L-amino-acyl-L-amino-acid hydrolase activity" EXACT [EC:3.4.13.18] synonym: "L-prolylglycine dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "N(2)-beta-alanylarginine dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "N2-beta-alanylarginine dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "non-specific dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "peptidase A activity" BROAD [EC:3.4.13.18] synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "prolinase activity" NARROW [EC:3.4.13.18] synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18] xref: EC:3.4.13.18 xref: MetaCyc:3.4.13.18-RXN is_obsolete: true replaced_by: GO:0016805 [Term] id: GO:0042316 name: penicillin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "penicillin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process [Term] id: GO:0042317 name: penicillin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "penicillin breakdown" EXACT [] synonym: "penicillin catabolism" EXACT [] synonym: "penicillin degradation" EXACT [] is_a: GO:0030655 ! beta-lactam antibiotic catabolic process is_a: GO:0042316 ! penicillin metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0042318 name: penicillin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "penicillin anabolism" EXACT [] synonym: "penicillin biosynthesis" EXACT [] synonym: "penicillin formation" EXACT [] synonym: "penicillin synthesis" EXACT [] is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process is_a: GO:0042316 ! penicillin metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0042320 name: regulation of circadian sleep/wake cycle, REM sleep namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." [GOC:jl, PMID:11506998] synonym: "regulation of REM sleep" EXACT [] is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep relationship: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep [Term] id: GO:0042321 name: negative regulation of circadian sleep/wake cycle, sleep namespace: biological_process def: "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators, GOC:jl, ISBN:0192800981] synonym: "down regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "down-regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "downregulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "inhibition of circadian sleep/wake cycle, sleep" NARROW [] synonym: "negative regulation of sleep" EXACT [] is_a: GO:0042754 ! negative regulation of circadian rhythm is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0042322 name: negative regulation of circadian sleep/wake cycle, REM sleep namespace: biological_process def: "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators, GOC:jl] synonym: "down regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "down-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "downregulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "inhibition of circadian sleep/wake cycle, REM sleep" NARROW [] synonym: "negative regulation of REM sleep" EXACT [] is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep relationship: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep [Term] id: GO:0042323 name: negative regulation of circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:jl] synonym: "down regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "down-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "downregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "inhibition of circadian sleep/wake cycle, non-REM sleep" NARROW [] synonym: "negative regulation of non-REM sleep" EXACT [] is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep relationship: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0042324 name: hypocretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the hypocretin receptor." [GOC:ceb, PMID:11988773] synonym: "hypocretin receptor ligand" NARROW [] synonym: "orexin receptor binding" EXACT [] synonym: "orexin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0042325 name: regulation of phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] subset: gosubset_prok is_a: GO:0019220 ! regulation of phosphate metabolic process relationship: regulates GO:0016310 ! phosphorylation [Term] id: GO:0042326 name: negative regulation of phosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] subset: gosubset_prok synonym: "down regulation of phosphorylation" EXACT [] synonym: "down-regulation of phosphorylation" EXACT [] synonym: "downregulation of phosphorylation" EXACT [] synonym: "inhibition of phosphorylation" NARROW [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045936 ! negative regulation of phosphate metabolic process relationship: negatively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042327 name: positive regulation of phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] subset: gosubset_prok synonym: "activation of phosphorylation" NARROW [] synonym: "stimulation of phosphorylation" NARROW [] synonym: "up regulation of phosphorylation" EXACT [] synonym: "up-regulation of phosphorylation" EXACT [] synonym: "upregulation of phosphorylation" EXACT [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045937 ! positive regulation of phosphate metabolic process relationship: positively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042328 name: heparan sulfate N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate." [GOC:ma] synonym: "heparan sulphate N-acetylglucosaminyltransferase activity" EXACT [] synonym: "heparin N-acetylglucosaminyltransferase activity" RELATED [] is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0042329 name: structural constituent of collagen and cuticulin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu] synonym: "structural constituent of cuticle" BROAD [] is_a: GO:0042302 ! structural constituent of cuticle [Term] id: GO:0042330 name: taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "directed movement in response to stimulus" EXACT [] xref: Wikipedia:Taxis is_a: GO:0009605 ! response to external stimulus is_a: GO:0040011 ! locomotion [Term] id: GO:0042331 name: phototaxis namespace: biological_process alt_id: GO:0046953 def: "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] synonym: "phototactic behavior" EXACT [] synonym: "phototactic behaviour" EXACT [] synonym: "taxis in response to light" EXACT [] xref: Wikipedia:Phototaxis is_a: GO:0009416 ! response to light stimulus is_a: GO:0009453 ! energy taxis [Term] id: GO:0042332 name: gravitaxis namespace: biological_process alt_id: GO:0048062 def: "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] synonym: "geotactic behavior" EXACT [] synonym: "geotactic behaviour" EXACT [] synonym: "geotaxis" EXACT [] synonym: "gravitactic behavior" EXACT [] synonym: "gravitactic behaviour" EXACT [] synonym: "taxis in response to gravitational stimulus" EXACT [] synonym: "taxis in response to gravity" EXACT [] is_a: GO:0009629 ! response to gravity is_a: GO:0042330 ! taxis [Term] id: GO:0042333 name: chemotaxis to oxidizable substrate namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose." [GOC:jl, PMID:11029423] synonym: "taxis in response to oxidizable substrate" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis [Term] id: GO:0042334 name: taxis to electron acceptor namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate." [GOC:jl, PMID:11029423] synonym: "taxis in response to electron acceptor" EXACT [] is_a: GO:0009453 ! energy taxis [Term] id: GO:0042335 name: cuticle development namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825] synonym: "cuticle anabolism" EXACT [] synonym: "cuticle biosynthesis" EXACT [] synonym: "cuticle biosynthetic process" EXACT [] synonym: "cuticle formation" EXACT [] synonym: "cuticle synthesis" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0042336 name: cuticle development involved in protein-based cuticle molting cycle namespace: biological_process def: "Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species." [GOC:dph, GOC:mtg_sensu, GOC:tb] synonym: "cuticle anabolism during molting" BROAD [] synonym: "cuticle biosynthetic process during molting" BROAD [] synonym: "cuticle formation during molting" BROAD [] synonym: "cuticle synthesis during molting" BROAD [] is_a: GO:0007592 ! protein-based cuticle development is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0018988 ! molting cycle, protein-based cuticle [Term] id: GO:0042337 name: cuticle development involved in chitin-based cuticle molting cycle namespace: biological_process def: "The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:jl, GOC:mtg_sensu, GOC:tb] synonym: "chitin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb] synonym: "cuticle anabolism during molting" BROAD [] synonym: "cuticle biosynthetic process during molting" BROAD [] synonym: "cuticle formation during molting" BROAD [] synonym: "cuticle synthesis during molting" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development is_a: GO:0042336 ! cuticle development involved in protein-based cuticle molting cycle relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0042338 name: cuticle development involved in collagen and cuticulin-based cuticle molting cycle namespace: biological_process def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu] synonym: "collagen and cuticulin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb] synonym: "cuticle anabolism during molting" BROAD [] synonym: "cuticle biosynthetic process during molting" BROAD [] synonym: "cuticle formation during molting" BROAD [] synonym: "cuticle synthesis during molting" BROAD [] is_a: GO:0040002 ! collagen and cuticulin-based cuticle development is_a: GO:0042336 ! cuticle development involved in protein-based cuticle molting cycle relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle [Term] id: GO:0042339 name: keratan sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators] subset: gosubset_prok synonym: "keratan sulfate metabolism" EXACT [] synonym: "keratan sulphate metabolic process" EXACT [] synonym: "keratan sulphate metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0042340 name: keratan sulfate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators] subset: gosubset_prok synonym: "keratan sulfate breakdown" EXACT [] synonym: "keratan sulfate catabolism" EXACT [] synonym: "keratan sulfate degradation" EXACT [] synonym: "keratan sulphate catabolic process" EXACT [] synonym: "keratan sulphate catabolism" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0042339 ! keratan sulfate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0042341 name: cyanogenic glycoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyanogenic glycoside metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0042342 name: cyanogenic glycoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyanogenic glycoside breakdown" EXACT [] synonym: "cyanogenic glycoside catabolism" EXACT [] synonym: "cyanogenic glycoside degradation" EXACT [] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0042341 ! cyanogenic glycoside metabolic process [Term] id: GO:0042343 name: indole glucosinolate metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan." [http://www.onelook.com/] subset: gosubset_prok synonym: "indole glucosinolate metabolism" EXACT [] is_a: GO:0019760 ! glucosinolate metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0042344 name: indole glucosinolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [http://www.onelook.com] subset: gosubset_prok synonym: "indole glucosinolate breakdown" EXACT [] synonym: "indole glucosinolate catabolism" EXACT [] synonym: "indole glucosinolate degradation" EXACT [] is_a: GO:0019762 ! glucosinolate catabolic process is_a: GO:0042343 ! indole glucosinolate metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process [Term] id: GO:0042345 name: regulation of NF-kappaB import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "regulation of NF-kappaB import into cell nucleus" EXACT [] synonym: "regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of NF-kappaB-nucleus import" EXACT [] is_a: GO:0042990 ! regulation of transcription factor import into nucleus relationship: regulates GO:0042348 ! NF-kappaB import into nucleus [Term] id: GO:0042346 name: positive regulation of NF-kappaB import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "activation of NF-kappaB import into nucleus" NARROW [] synonym: "positive regulation of NF-kappaB import into cell nucleus" EXACT [] synonym: "positive regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of NF-kappaB-nucleus import" EXACT [] synonym: "stimulation of NF-kappaB import into nucleus" NARROW [] synonym: "up regulation of NF-kappaB import into nucleus" EXACT [] synonym: "up-regulation of NF-kappaB import into nucleus" EXACT [] synonym: "upregulation of NF-kappaB import into nucleus" EXACT [] is_a: GO:0042345 ! regulation of NF-kappaB import into nucleus is_a: GO:0042993 ! positive regulation of transcription factor import into nucleus relationship: positively_regulates GO:0042348 ! NF-kappaB import into nucleus [Term] id: GO:0042347 name: negative regulation of NF-kappaB import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "down regulation of NF-kappaB import into nucleus" EXACT [] synonym: "down-regulation of NF-kappaB import into nucleus" EXACT [] synonym: "downregulation of NF-kappaB import into nucleus" EXACT [] synonym: "inhibition of NF-kappaB import into nucleus" NARROW [] synonym: "negative regulation of NF-kappaB import into cell nucleus" EXACT [] synonym: "negative regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of NF-kappaB-nucleus import" EXACT [] is_a: GO:0042345 ! regulation of NF-kappaB import into nucleus is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus relationship: negatively_regulates GO:0042348 ! NF-kappaB import into nucleus [Term] id: GO:0042348 name: NF-kappaB import into nucleus namespace: biological_process def: "The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "NF-kappaB import into cell nucleus" EXACT [] synonym: "NF-kappaB protein-nucleus import" EXACT [] synonym: "NF-kappaB transport from cytoplasm to nucleus" EXACT [] synonym: "NF-kappaB-nucleus import" EXACT [] is_a: GO:0042991 ! transcription factor import into nucleus [Term] id: GO:0042349 name: guiding stereospecific synthesis activity namespace: molecular_function def: "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis." [GOC:ma] synonym: "dirigent protein" NARROW [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0042350 name: GDP-L-fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:jl] subset: gosubset_prok synonym: "GDP-L-fucose anabolism" EXACT [] synonym: "GDP-L-fucose biosynthesis" EXACT [] synonym: "GDP-L-fucose formation" EXACT [] synonym: "GDP-L-fucose synthesis" EXACT [] is_a: GO:0006005 ! L-fucose biosynthetic process is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046368 ! GDP-L-fucose metabolic process [Term] id: GO:0042351 name: 'de novo' GDP-L-fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [EC:1.1.1.271, PMID:11030750] subset: gosubset_prok synonym: "'de novo' GDP-L-fucose anabolism" EXACT [] synonym: "'de novo' GDP-L-fucose biosynthesis" EXACT [] synonym: "'de novo' GDP-L-fucose formation" EXACT [] synonym: "'de novo' GDP-L-fucose synthesis" EXACT [] synonym: "GDP-L-fucose biosynthesis, de novo pathway" EXACT [] synonym: "GDP-L-fucose biosynthetic process, de novo pathway" EXACT [] xref: MetaCyc:PWY-66 is_a: GO:0042350 ! GDP-L-fucose biosynthetic process [Term] id: GO:0042352 name: GDP-L-fucose salvage namespace: biological_process def: "The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)." [GOC:ma] subset: gosubset_prok synonym: "GDP-L-fucose biosynthesis, salvage pathway" EXACT [] synonym: "GDP-L-fucose biosynthetic process, salvage pathway" EXACT [] xref: MetaCyc:PWY-6 is_a: GO:0042350 ! GDP-L-fucose biosynthetic process is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0042353 name: fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose)." [GOC:jl] subset: gosubset_prok synonym: "fucose anabolism" EXACT [] synonym: "fucose biosynthesis" EXACT [] synonym: "fucose formation" EXACT [] synonym: "fucose synthesis" EXACT [] is_a: GO:0006004 ! fucose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0042354 name: L-fucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-fucose metabolism" EXACT [] is_a: GO:0006004 ! fucose metabolic process [Term] id: GO:0042355 name: L-fucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose)." [GOC:jl] subset: gosubset_prok synonym: "L-fucose breakdown" EXACT [] synonym: "L-fucose catabolism" EXACT [] synonym: "L-fucose degradation" EXACT [] is_a: GO:0019317 ! fucose catabolic process is_a: GO:0042354 ! L-fucose metabolic process [Term] id: GO:0042356 name: GDP-4-dehydro-D-rhamnose reductase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed." [BRENDA:1.1.1.187, EC:1.1.1.187] subset: gosubset_prok synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" EXACT [EC:1.1.1.187] synonym: "GDP-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187] synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.187] synonym: "guanosine diphosphate-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187] xref: EC:1.1.1.187 xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0042357 name: thiamine diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [CHEBI:45931, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "thiamin diphosphate metabolic process" EXACT [GOC:curators] synonym: "thiamin diphosphate metabolism" EXACT [] synonym: "thiamin pyrophosphate metabolic process" EXACT [] synonym: "thiamin pyrophosphate metabolism" EXACT [] synonym: "thiamine diphosphate metabolism" EXACT [] synonym: "thiamine pyrophosphate metabolic process" EXACT [] synonym: "thiamine pyrophosphate metabolism" EXACT [] synonym: "TPP metabolic process" EXACT [] synonym: "TPP metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0042723 ! thiamine-containing compound metabolic process [Term] id: GO:0042358 name: thiamin diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "thiamin diphosphate breakdown" EXACT [] synonym: "thiamin diphosphate catabolism" EXACT [] synonym: "thiamin diphosphate degradation" EXACT [] synonym: "thiamin pyrophosphate catabolic process" EXACT [] synonym: "thiamin pyrophosphate catabolism" EXACT [] synonym: "thiamine diphosphate catabolic process" EXACT [] synonym: "thiamine diphosphate catabolism" EXACT [] synonym: "thiamine pyrophosphate catabolic process" EXACT [] synonym: "thiamine pyrophosphate catabolism" EXACT [] synonym: "TPP catabolic process" EXACT [] synonym: "TPP catabolism" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042357 ! thiamine diphosphate metabolic process is_a: GO:0042725 ! thiamine-containing compound catabolic process [Term] id: GO:0042359 name: vitamin D metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309] subset: gosubset_prok synonym: "calciferol metabolic process" NARROW [] synonym: "calciferol metabolism" NARROW [] synonym: "cholecalciferol metabolic process" NARROW [] synonym: "cholecalciferol metabolism" NARROW [] synonym: "ergocalciferol metabolic process" NARROW [] synonym: "ergocalciferol metabolism" NARROW [] synonym: "vitamin D metabolism" EXACT [] xref: Reactome:1253560 "Vitamin D (calciferol) metabolism" xref: Reactome:1280498 "Vitamin D (calciferol) metabolism" xref: Reactome:1299326 "Vitamin D (calciferol) metabolism" xref: Reactome:1327077 "Vitamin D (calciferol) metabolism" xref: Reactome:1353171 "Vitamin D (calciferol) metabolism" xref: Reactome:1373352 "Vitamin D (calciferol) metabolism" xref: Reactome:1393375 "Vitamin D (calciferol) metabolism" xref: Reactome:1417872 "Vitamin D (calciferol) metabolism" xref: Reactome:1450961 "Vitamin D (calciferol) metabolism" xref: Reactome:1471347 "Vitamin D (calciferol) metabolism" xref: Reactome:1483307 "Vitamin D (calciferol) metabolism" xref: Reactome:196791 "Vitamin D (calciferol) metabolism" is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0008202 ! steroid metabolic process [Term] id: GO:0042360 name: vitamin E metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alpha-tocopherol metabolic process" NARROW [] synonym: "alpha-tocopherol metabolism" NARROW [] synonym: "tocopherol metabolic process" EXACT [] synonym: "tocopherol metabolism" EXACT [] synonym: "vitamin E metabolism" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0042361 name: menaquinone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "menaquinone breakdown" EXACT [] synonym: "menaquinone catabolism" EXACT [] synonym: "menaquinone degradation" EXACT [] synonym: "menatetrenone catabolic process" EXACT [] synonym: "menatetrenone catabolism" EXACT [] synonym: "multiprenylmenaquinone catabolic process" EXACT [] synonym: "multiprenylmenaquinone catabolism" EXACT [] synonym: "vitamin K2 catabolic process" EXACT [] synonym: "vitamin K2 catabolism" EXACT [] is_a: GO:0009233 ! menaquinone metabolic process is_a: GO:0042377 ! vitamin K catabolic process [Term] id: GO:0042362 name: fat-soluble vitamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fat-soluble vitamin anabolism" EXACT [] synonym: "fat-soluble vitamin biosynthesis" EXACT [] synonym: "fat-soluble vitamin formation" EXACT [] synonym: "fat-soluble vitamin synthesis" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0009110 ! vitamin biosynthetic process [Term] id: GO:0042363 name: fat-soluble vitamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fat-soluble vitamin breakdown" EXACT [] synonym: "fat-soluble vitamin catabolism" EXACT [] synonym: "fat-soluble vitamin degradation" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0009111 ! vitamin catabolic process [Term] id: GO:0042364 name: water-soluble vitamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl] subset: gosubset_prok synonym: "water-soluble vitamin anabolism" EXACT [] synonym: "water-soluble vitamin biosynthesis" EXACT [] synonym: "water-soluble vitamin formation" EXACT [] synonym: "water-soluble vitamin synthesis" EXACT [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009110 ! vitamin biosynthetic process [Term] id: GO:0042365 name: water-soluble vitamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "water-soluble vitamin breakdown" EXACT [] synonym: "water-soluble vitamin catabolism" EXACT [] synonym: "water-soluble vitamin degradation" EXACT [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009111 ! vitamin catabolic process [Term] id: GO:0042366 name: cobalamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] subset: gosubset_prok synonym: "cobalamin breakdown" EXACT [] synonym: "cobalamin catabolism" EXACT [] synonym: "cobalamin degradation" EXACT [] synonym: "vitamin B12 catabolic process" EXACT [] synonym: "vitamin B12 catabolism" EXACT [] is_a: GO:0006787 ! porphyrin catabolic process is_a: GO:0009235 ! cobalamin metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process [Term] id: GO:0042367 name: biotin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "biotin breakdown" EXACT [] synonym: "biotin catabolism" EXACT [] synonym: "biotin degradation" EXACT [] synonym: "vitamin B7 catabolic process" EXACT [] synonym: "vitamin B7 catabolism" EXACT [] synonym: "vitamin H catabolic process" EXACT [] synonym: "vitamin H catabolism" EXACT [] is_a: GO:0006768 ! biotin metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0042368 name: vitamin D biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309] subset: gosubset_prok synonym: "calciferol biosynthesis" NARROW [] synonym: "calciferol biosynthetic process" NARROW [] synonym: "cholecalciferol biosynthesis" NARROW [] synonym: "cholecalciferol biosynthetic process" NARROW [] synonym: "ergocalciferol biosynthesis" NARROW [] synonym: "ergocalciferol biosynthetic process" NARROW [] synonym: "vitamin D anabolism" EXACT [] synonym: "vitamin D biosynthesis" EXACT [] synonym: "vitamin D formation" EXACT [] synonym: "vitamin D synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042359 ! vitamin D metabolic process is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process [Term] id: GO:0042369 name: vitamin D catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309] subset: gosubset_prok synonym: "calciferol catabolic process" NARROW [] synonym: "calciferol catabolism" NARROW [] synonym: "cholecalciferol biosynthesis" NARROW [] synonym: "cholecalciferol biosynthetic process" NARROW [] synonym: "ergocalciferol biosynthesis" NARROW [] synonym: "ergocalciferol biosynthetic process" NARROW [] synonym: "vitamin D breakdown" EXACT [] synonym: "vitamin D catabolism" EXACT [] synonym: "vitamin D degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0042359 ! vitamin D metabolic process is_a: GO:0042363 ! fat-soluble vitamin catabolic process [Term] id: GO:0042370 name: thiamine diphosphate dephosphorylation namespace: biological_process def: "The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "thiamin diphosphate dephosphorylation" EXACT [GOC:curators] synonym: "TPP dephosphorylation" EXACT [] is_a: GO:0042357 ! thiamine diphosphate metabolic process [Term] id: GO:0042371 name: vitamin K biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "naphthoquinone metabolic process" BROAD [] synonym: "naphthoquinone metabolism" BROAD [] synonym: "vitamin K anabolism" EXACT [] synonym: "vitamin K biosynthesis" EXACT [] synonym: "vitamin K formation" EXACT [] synonym: "vitamin K synthesis" EXACT [] is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process is_a: GO:0042373 ! vitamin K metabolic process is_a: GO:0045426 ! quinone cofactor biosynthetic process [Term] id: GO:0042372 name: phylloquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "phylloquinone anabolism" EXACT [] synonym: "phylloquinone biosynthesis" EXACT [] synonym: "phylloquinone formation" EXACT [] synonym: "phylloquinone synthesis" EXACT [] synonym: "phytomenadione biosynthesis" EXACT [] synonym: "phytomenadione biosynthetic process" EXACT [] synonym: "phytonadione biosynthesis" EXACT [] synonym: "phytonadione biosynthetic process" EXACT [] synonym: "phytylmenaquinone biosynthesis" EXACT [] synonym: "phytylmenaquinone biosynthetic process" EXACT [] synonym: "vitamin K1 biosynthesis" EXACT [] synonym: "vitamin K1 biosynthetic process" EXACT [] xref: MetaCyc:PWY-5027 is_a: GO:0042371 ! vitamin K biosynthetic process is_a: GO:0042374 ! phylloquinone metabolic process [Term] id: GO:0042373 name: vitamin K metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "naphthoquinone metabolic process" BROAD [] synonym: "naphthoquinone metabolism" BROAD [] synonym: "vitamin K metabolism" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042375 ! quinone cofactor metabolic process [Term] id: GO:0042374 name: phylloquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "phylloquinone metabolism" EXACT [] synonym: "phytomenadione metabolic process" EXACT [] synonym: "phytomenadione metabolism" EXACT [] synonym: "phytonadione metabolic process" EXACT [] synonym: "phytonadione metabolism" EXACT [] synonym: "phytylmenaquinone metabolic process" EXACT [] synonym: "phytylmenaquinone metabolism" EXACT [] synonym: "vitamin K1 metabolic process" EXACT [] synonym: "vitamin K1 metabolism" EXACT [] is_a: GO:0042373 ! vitamin K metabolic process [Term] id: GO:0042375 name: quinone cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving quinone cofactors." [GOC:go_curators] subset: gosubset_prok synonym: "quinone cofactor metabolism" EXACT [] is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0042376 name: phylloquinone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "phylloquinone breakdown" EXACT [] synonym: "phylloquinone catabolism" EXACT [] synonym: "phylloquinone degradation" EXACT [] synonym: "phytomenadione catabolic process" EXACT [] synonym: "phytomenadione catabolism" EXACT [] synonym: "phytonadione catabolic process" EXACT [] synonym: "phytonadione catabolism" EXACT [] synonym: "phytylmenaquinone catabolic process" EXACT [] synonym: "phytylmenaquinone catabolism" EXACT [] synonym: "vitamin K1 catabolic process" EXACT [] synonym: "vitamin K1 catabolism" EXACT [] is_a: GO:0042374 ! phylloquinone metabolic process is_a: GO:0042377 ! vitamin K catabolic process [Term] id: GO:0042377 name: vitamin K catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "naphthoquinone catabolic process" EXACT [] synonym: "naphthoquinone catabolism" EXACT [] synonym: "vitamin K breakdown" EXACT [] synonym: "vitamin K catabolism" EXACT [] synonym: "vitamin K degradation" EXACT [] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042363 ! fat-soluble vitamin catabolic process is_a: GO:0042373 ! vitamin K metabolic process is_a: GO:0042378 ! quinone cofactor catabolic process [Term] id: GO:0042378 name: quinone cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of quinone cofactors." [GOC:go_curators] subset: gosubset_prok synonym: "quinone cofactor breakdown" EXACT [] synonym: "quinone cofactor catabolism" EXACT [] synonym: "quinone cofactor degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042375 ! quinone cofactor metabolic process [Term] id: GO:0042379 name: chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any chemokine receptor." [GOC:ai] synonym: "chemokine receptor ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0042380 name: hydroxymethylbutenyl pyrophosphate reductase activity namespace: molecular_function def: "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate." [GOC:js] comment: Note that the enzyme performing this function has only recently been characterized, and not completely (see PMID:11818558). The common and systematic names have been suggested by TIGR, who have recently compiled an HMM model for this gene (TIGR00216). The enzyme appears to catalyze the final step in the non-mevalonate terpene biosynthesis pathway. Its two products, isopentenyl pyrophosphate and dimethylallyl pyrophosphate, are apparently generated from a common intermediate formed by the enzyme. The mechanism and identity of the reductant have not yet been determined. subset: gosubset_prok synonym: "(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0042381 name: hemolymph coagulation namespace: biological_process def: "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10561606, PMID:11915949] synonym: "hemolymph clotting" EXACT [] is_a: GO:0006959 ! humoral immune response is_a: GO:0007599 ! hemostasis is_a: GO:0045087 ! innate immune response is_a: GO:0050817 ! coagulation relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0042382 name: paraspeckles namespace: cellular_component def: "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] xref: Wikipedia:Paraspeckle is_a: GO:0016604 ! nuclear body [Term] id: GO:0042383 name: sarcolemma namespace: cellular_component def: "The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Sarcolemma is_a: GO:0005886 ! plasma membrane [Term] id: GO:0042384 name: cilium assembly namespace: biological_process def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ciliogenesis" EXACT [] synonym: "cilium biogenesis" RELATED [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0030031 ! cell projection assembly relationship: part_of GO:0060271 ! cilium morphogenesis [Term] id: GO:0042385 name: myosin III complex namespace: cellular_component def: "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0042386 name: hemocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723] synonym: "arthropod blood cell differentiation" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0030154 ! cell differentiation [Term] id: GO:0042387 name: plasmatocyte differentiation namespace: biological_process def: "The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791] is_a: GO:0042386 ! hemocyte differentiation [Term] id: GO:0042388 name: gibberellic acid mediated signaling pathway, G-alpha-dependent namespace: biological_process def: "A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362] synonym: "gibberellic acid mediated signalling, G-alpha-dependent" EXACT [] is_a: GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0042389 name: omega-3 fatty acid desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain." [GOC:jl, PMID:9037020] xref: EC:1.14.99.- is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0042390 name: gibberellic acid mediated signaling pathway, G-alpha-independent namespace: biological_process def: "A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362] synonym: "gibberellic acid mediated signalling, G-alpha-independent" EXACT [] is_a: GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0042391 name: regulation of membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006873 ! cellular ion homeostasis [Term] id: GO:0042392 name: sphingosine-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:11331102] synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT [] synonym: "SPP phosphatase activity" EXACT [] synonym: "SPPase activity" EXACT [] xref: MetaCyc:RXN3DJ-25 xref: Reactome:11442 "sphingosine-1-phosphate phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0042393 name: histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] synonym: "histone-specific chaperone activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042394 name: ecdysis, protein-based cuticle namespace: biological_process def: "The shedding of the old protein-based cuticular fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0018988 ! molting cycle, protein-based cuticle [Term] id: GO:0042395 name: ecdysis, collagen and cuticulin-based cuticle namespace: biological_process def: "The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu] is_a: GO:0042394 ! ecdysis, protein-based cuticle relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle [Term] id: GO:0042396 name: phosphagen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphagen anabolism" EXACT [] synonym: "phosphagen biosynthesis" EXACT [] synonym: "phosphagen formation" EXACT [] synonym: "phosphagen synthesis" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0042397 name: phosphagen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphagen breakdown" EXACT [] synonym: "phosphagen catabolism" EXACT [] synonym: "phosphagen degradation" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process [Term] id: GO:0042398 name: cellular modified amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [CHEBI:25359, GOC:ai] subset: gosubset_prok synonym: "amino acid derivative biosynthetic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative anabolism" EXACT [] synonym: "cellular amino acid derivative biosynthesis" EXACT [] synonym: "cellular amino acid derivative biosynthetic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative formation" EXACT [] synonym: "cellular amino acid derivative synthesis" EXACT [] synonym: "cellular modified amino acid anabolism" EXACT [GOC:mah] synonym: "cellular modified amino acid biosynthesis" EXACT [GOC:mah] synonym: "cellular modified amino acid formation" EXACT [GOC:mah] synonym: "cellular modified amino acid synthesis" EXACT [GOC:mah] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0008652 ! cellular amino acid biosynthetic process [Term] id: GO:0042399 name: ectoine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] subset: gosubset_prok synonym: "ectoine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0042400 name: ectoine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] subset: gosubset_prok synonym: "ectoine breakdown" EXACT [] synonym: "ectoine catabolism" EXACT [] synonym: "ectoine degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042399 ! ectoine metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0042401 name: cellular biogenic amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] subset: gosubset_prok synonym: "biogenic amine anabolism" EXACT [] synonym: "biogenic amine biosynthesis" EXACT [] synonym: "biogenic amine formation" EXACT [] synonym: "biogenic amine synthesis" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0009309 ! amine biosynthetic process [Term] id: GO:0042402 name: cellular biogenic amine catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "biogenic amine breakdown" EXACT [] synonym: "biogenic amine catabolism" EXACT [] synonym: "biogenic amine degradation" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0009310 ! amine catabolic process [Term] id: GO:0042403 name: thyroid hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "thyroid hormone metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042404 name: thyroid hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "thyroid hormone breakdown" EXACT [] synonym: "thyroid hormone catabolism" EXACT [] synonym: "thyroid hormone degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042403 ! thyroid hormone metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0042405 name: nuclear inclusion body namespace: cellular_component def: "An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl] is_a: GO:0016234 ! inclusion body is_a: GO:0044428 ! nuclear part [Term] id: GO:0042406 name: extrinsic to endoplasmic reticulum membrane namespace: cellular_component def: "Loosely bound to one surface of the endoplasmic reticulum membrane, but not integrated into the hydrophobic region." [GOC:curators] synonym: "extrinsic to ER membrane" EXACT [] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0042407 name: cristae formation namespace: biological_process def: "The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0007007 ! inner mitochondrial membrane organization [Term] id: GO:0042408 name: myrcene/(E)-beta-ocimene synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes." [GOC:cr, PMID:10700382] comment: This term was made obsolete because it represents two activities. synonym: "myrcene/ocimene synthase activity" EXACT [] xref: EC:4.6.-.- is_obsolete: true [Term] id: GO:0042409 name: caffeoyl-CoA O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104] subset: gosubset_prok synonym: "caffeoyl coenzyme A methyltransferase activity" EXACT [] synonym: "caffeoyl-CoA 3-O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104] synonym: "trans-caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104] xref: EC:2.1.1.104 xref: MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0042410 name: 6-carboxyhexanoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H(+) + pimelyl-CoA." [EC:6.2.1.14, RHEA:14784] subset: gosubset_prok synonym: "6-carboxyhexanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.14] synonym: "6-carboxyhexanoyl-CoA synthetase activity" EXACT [EC:6.2.1.14] synonym: "pimeloyl-CoA synthetase activity" EXACT [EC:6.2.1.14] synonym: "pimelyl-CoA synthetase activity" EXACT [EC:6.2.1.14] xref: EC:6.2.1.14 xref: KEGG:R03209 xref: MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN xref: RHEA:14784 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0042412 name: taurine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] subset: gosubset_prok synonym: "taurine anabolism" EXACT [] synonym: "taurine biosynthesis" EXACT [] synonym: "taurine formation" EXACT [] synonym: "taurine synthesis" EXACT [] is_a: GO:0009309 ! amine biosynthetic process is_a: GO:0019530 ! taurine metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0042413 name: carnitine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "carnitine breakdown" EXACT [] synonym: "carnitine catabolism" EXACT [] synonym: "carnitine degradation" EXACT [] synonym: "vitamin Bt catabolic process" EXACT [] synonym: "vitamin Bt catabolism" EXACT [] is_a: GO:0006579 ! betaine catabolic process is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009437 ! carnitine metabolic process [Term] id: GO:0042414 name: epinephrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "adrenaline metabolic process" EXACT [] synonym: "adrenaline metabolism" EXACT [] synonym: "epinephrine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process [Term] id: GO:0042415 name: norepinephrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "levarterenol metabolic process" EXACT [] synonym: "levarterenol metabolism" EXACT [] synonym: "noradrenaline metabolic process" EXACT [] synonym: "noradrenaline metabolism" EXACT [] synonym: "norepinephrine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process [Term] id: GO:0042416 name: dopamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "dopamine anabolism" EXACT [] synonym: "dopamine biosynthesis" EXACT [] synonym: "dopamine formation" EXACT [] synonym: "dopamine synthesis" EXACT [] is_a: GO:0042417 ! dopamine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process [Term] id: GO:0042417 name: dopamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "dopamine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process [Term] id: GO:0042418 name: epinephrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "adrenaline biosynthesis" EXACT [] synonym: "adrenaline biosynthetic process" EXACT [] synonym: "epinephrine anabolism" EXACT [] synonym: "epinephrine biosynthesis" EXACT [] synonym: "epinephrine formation" EXACT [] synonym: "epinephrine synthesis" EXACT [] is_a: GO:0042414 ! epinephrine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process [Term] id: GO:0042419 name: epinephrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "adrenaline catabolic process" EXACT [] synonym: "adrenaline catabolism" EXACT [] synonym: "epinephrine breakdown" EXACT [] synonym: "epinephrine catabolism" EXACT [] synonym: "epinephrine degradation" EXACT [] is_a: GO:0042414 ! epinephrine metabolic process is_a: GO:0042424 ! catecholamine catabolic process [Term] id: GO:0042420 name: dopamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "dopamine breakdown" EXACT [] synonym: "dopamine catabolism" EXACT [] synonym: "dopamine degradation" EXACT [] is_a: GO:0042417 ! dopamine metabolic process is_a: GO:0042424 ! catecholamine catabolic process [Term] id: GO:0042421 name: norepinephrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "levarterenol biosynthesis" EXACT [] synonym: "levarterenol biosynthetic process" EXACT [] synonym: "noradrenaline biosynthesis" EXACT [] synonym: "noradrenaline biosynthetic process" EXACT [] synonym: "norepinephrine anabolism" EXACT [] synonym: "norepinephrine biosynthesis" EXACT [] synonym: "norepinephrine formation" EXACT [] synonym: "norepinephrine synthesis" EXACT [] is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process [Term] id: GO:0042422 name: norepinephrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "levarterenol catabolic process" EXACT [] synonym: "levarterenol catabolism" EXACT [] synonym: "noradrenaline catabolic process" EXACT [] synonym: "noradrenaline catabolism" EXACT [] synonym: "norepinephrine breakdown" EXACT [] synonym: "norepinephrine catabolism" EXACT [] synonym: "norepinephrine degradation" EXACT [] xref: Wikipedia:Norepinephrine#Degradation is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042424 ! catecholamine catabolic process [Term] id: GO:0042423 name: catecholamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "catecholamine anabolism" EXACT [] synonym: "catecholamine biosynthesis" EXACT [] synonym: "catecholamine formation" EXACT [] synonym: "catecholamine synthesis" EXACT [] xref: Wikipedia:Catecholamines is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0009713 ! catechol biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0042424 name: catecholamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "catecholamine breakdown" EXACT [] synonym: "catecholamine catabolism" EXACT [] synonym: "catecholamine degradation" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0019614 ! catechol catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] id: GO:0042425 name: choline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "choline anabolism" EXACT [] synonym: "choline biosynthesis" EXACT [] synonym: "choline formation" EXACT [] synonym: "choline synthesis" EXACT [] xref: MetaCyc:PWY-4762 is_a: GO:0019695 ! choline metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0042426 name: choline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "choline breakdown" EXACT [] synonym: "choline catabolism" EXACT [] synonym: "choline degradation" EXACT [] is_a: GO:0019695 ! choline metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0042427 name: serotonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "serotonin anabolism" EXACT [] synonym: "serotonin biosynthesis" EXACT [] synonym: "serotonin formation" EXACT [] synonym: "serotonin synthesis" EXACT [] xref: Wikipedia:Serotonin is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0046219 ! indolalkylamine biosynthetic process [Term] id: GO:0042428 name: serotonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "serotonin metabolism" EXACT [] is_a: GO:0006586 ! indolalkylamine metabolic process [Term] id: GO:0042429 name: serotonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "serotonin breakdown" EXACT [] synonym: "serotonin catabolism" EXACT [] synonym: "serotonin degradation" EXACT [] is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0046218 ! indolalkylamine catabolic process [Term] id: GO:0042430 name: indole-containing compound metabolic process namespace: biological_process alt_id: GO:0042434 def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl, GOC:mah] subset: gosubset_prok synonym: "indole and derivative metabolic process" EXACT [GOC:curators] synonym: "indole and derivative metabolism" EXACT [] synonym: "indole derivative metabolic process" NARROW [GOC:curators] synonym: "indole derivative metabolism" NARROW [GOC:curators] synonym: "indole-containing compound metabolism" EXACT [GOC:curators] synonym: "ketole metabolic process" EXACT [] synonym: "ketole metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0042431 name: indole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [CHEBI:35581, GOC:jl] subset: gosubset_prok synonym: "indole metabolism" EXACT [] is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0042432 name: indole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [CHEBI:35581, GOC:jl] subset: gosubset_prok synonym: "indole anabolism" EXACT [] synonym: "indole biosynthesis" EXACT [] synonym: "indole formation" EXACT [] synonym: "indole synthesis" EXACT [] is_a: GO:0042431 ! indole metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process [Term] id: GO:0042433 name: indole catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [CHEBI:35581, GOC:jl] subset: gosubset_prok synonym: "indole breakdown" EXACT [] synonym: "indole catabolism" EXACT [] synonym: "indole degradation" EXACT [] is_a: GO:0042431 ! indole metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process [Term] id: GO:0042435 name: indole-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl] subset: gosubset_prok synonym: "indole derivative biosynthesis" EXACT [] synonym: "indole derivative biosynthetic process" EXACT [GOC:curators] synonym: "indole-containing compound anabolism" EXACT [GOC:curators] synonym: "indole-containing compound biosynthesis" EXACT [GOC:curators] synonym: "indole-containing compound formation" EXACT [GOC:curators] synonym: "indole-containing compound synthesis" EXACT [GOC:curators] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0042436 name: indole-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl] subset: gosubset_prok synonym: "indole derivative catabolic process" EXACT [GOC:curators] synonym: "indole derivative catabolism" EXACT [] synonym: "indole-containing compound breakdown" EXACT [GOC:curators] synonym: "indole-containing compound catabolism" EXACT [GOC:curators] synonym: "indole-containing compound degradation" EXACT [GOC:curators] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0042437 name: indoleacetic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:jl] subset: gosubset_prok synonym: "IAA catabolic process" EXACT [] synonym: "indole acetic acid catabolic process" EXACT [] synonym: "indole acetic acid catabolism" EXACT [] synonym: "indoleacetic acid breakdown" EXACT [] synonym: "indoleacetic acid catabolism" EXACT [] synonym: "indoleacetic acid degradation" EXACT [] is_a: GO:0009683 ! indoleacetic acid metabolic process is_a: GO:0009852 ! auxin catabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0042438 name: melanin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators] subset: gosubset_prok synonym: "melanin anabolism" EXACT [] synonym: "melanin biosynthesis" EXACT [] synonym: "melanin formation" EXACT [] synonym: "melanin synthesis" EXACT [] is_a: GO:0006582 ! melanin metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0042439 name: ethanolamine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it." [CHEBI:16000, GOC:mah] subset: gosubset_prok synonym: "ethanolamine and derivative metabolic process" EXACT [GOC:curators] synonym: "ethanolamine and derivative metabolism" EXACT [] synonym: "ethanolamine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006576 ! cellular biogenic amine metabolic process [Term] id: GO:0042440 name: pigment metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "pigment metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0042441 name: eye pigment metabolic process namespace: biological_process def: "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] synonym: "eye pigment metabolism" EXACT [] is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation relationship: part_of GO:0048069 ! eye pigmentation [Term] id: GO:0042442 name: melatonin catabolic process namespace: biological_process alt_id: GO:0042449 def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl] subset: gosubset_prok synonym: "melatonin breakdown" EXACT [] synonym: "melatonin catabolism" EXACT [] synonym: "melatonin degradation" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0046218 ! indolalkylamine catabolic process [Term] id: GO:0042443 name: phenylethylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] synonym: "phenylethylamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0042444 name: phenylethylamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] synonym: "phenylethylamine anabolism" EXACT [] synonym: "phenylethylamine biosynthesis" EXACT [] synonym: "phenylethylamine formation" EXACT [] synonym: "phenylethylamine synthesis" EXACT [] is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0042443 ! phenylethylamine metabolic process [Term] id: GO:0042445 name: hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "hormone metabolism" EXACT [] is_a: GO:0008152 ! metabolic process is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0042446 name: hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl] subset: gosubset_prok synonym: "hormone anabolism" EXACT [] synonym: "hormone biosynthesis" EXACT [] synonym: "hormone formation" EXACT [] synonym: "hormone synthesis" EXACT [] xref: Reactome:1253088 "Hormone biosynthesis" xref: Reactome:1280023 "Hormone biosynthesis" xref: Reactome:1298909 "Hormone biosynthesis" xref: Reactome:1326593 "Hormone biosynthesis" xref: Reactome:1352704 "Hormone biosynthesis" xref: Reactome:1372920 "Hormone biosynthesis" xref: Reactome:1392936 "Hormone biosynthesis" xref: Reactome:1417413 "Hormone biosynthesis" xref: Reactome:1450510 "Hormone biosynthesis" xref: Reactome:1471276 "Hormone biosynthesis" xref: Reactome:1483247 "Hormone biosynthesis" xref: Reactome:1496933 "Hormone biosynthesis" xref: Reactome:1514318 "Hormone biosynthesis" xref: Reactome:1521186 "Hormone biosynthesis" xref: Reactome:1526929 "Hormone biosynthesis" xref: Reactome:1532665 "Hormone biosynthesis" xref: Reactome:1536087 "Hormone biosynthesis" xref: Reactome:1538058 "Hormone biosynthesis" xref: Reactome:1539339 "Hormone biosynthesis" xref: Reactome:1540355 "Hormone biosynthesis" xref: Reactome:209945 "Hormone biosynthesis" is_a: GO:0009058 ! biosynthetic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042447 name: hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl] subset: gosubset_prok synonym: "hormone breakdown" EXACT [] synonym: "hormone catabolism" EXACT [] synonym: "hormone degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042448 name: progesterone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone metabolism" EXACT [] is_a: GO:0008207 ! C21-steroid hormone metabolic process [Term] id: GO:0042450 name: arginine biosynthetic process via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl] subset: gosubset_prok synonym: "arginine anabolism via ornithine" EXACT [] synonym: "arginine formation via ornithine" EXACT [] synonym: "arginine synthesis via ornithine" EXACT [] is_a: GO:0006526 ! arginine biosynthetic process is_a: GO:0006591 ! ornithine metabolic process [Term] id: GO:0042451 name: purine nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] subset: gosubset_prok synonym: "purine nucleoside anabolism" EXACT [] synonym: "purine nucleoside biosynthesis" EXACT [] synonym: "purine nucleoside formation" EXACT [] synonym: "purine nucleoside synthesis" EXACT [] is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0042278 ! purine nucleoside metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0042452 name: deoxyguanosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [CHEBI:17172, GOC:jl] subset: gosubset_prok synonym: "deoxyguanosine anabolism" EXACT [] synonym: "deoxyguanosine biosynthesis" EXACT [] synonym: "deoxyguanosine formation" EXACT [] synonym: "deoxyguanosine synthesis" EXACT [] is_a: GO:0042453 ! deoxyguanosine metabolic process is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process [Term] id: GO:0042453 name: deoxyguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [CHEBI:17172, GOC:jl] subset: gosubset_prok synonym: "deoxyguanosine metabolism" EXACT [] is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0042454 name: ribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl] subset: gosubset_prok synonym: "ribonucleoside breakdown" EXACT [] synonym: "ribonucleoside catabolism" EXACT [] synonym: "ribonucleoside degradation" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0009164 ! nucleoside catabolic process [Term] id: GO:0042455 name: ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl] subset: gosubset_prok synonym: "ribonucleoside anabolism" EXACT [] synonym: "ribonucleoside biosynthesis" EXACT [] synonym: "ribonucleoside formation" EXACT [] synonym: "ribonucleoside synthesis" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0009163 ! nucleoside biosynthetic process [Term] id: GO:0042457 name: ethylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:jl, ISBN:0387969845] subset: gosubset_prok synonym: "ethene catabolic process" EXACT [] synonym: "ethene catabolism" EXACT [] synonym: "ethylene breakdown" EXACT [] synonym: "ethylene catabolism" EXACT [] synonym: "ethylene degradation" EXACT [] is_a: GO:0009692 ! ethylene metabolic process is_a: GO:0043451 ! alkene catabolic process [Term] id: GO:0042458 name: nopaline catabolic process to proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline." [GOC:go_curators] subset: gosubset_prok synonym: "nopaline breakdown to proline" EXACT [] synonym: "nopaline degradation to proline" EXACT [] xref: MetaCyc:NOPALINEDEG-PWY is_a: GO:0006560 ! proline metabolic process is_a: GO:0019468 ! nopaline catabolic process [Term] id: GO:0042459 name: octopine catabolic process to proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline." [GOC:go_curators] subset: gosubset_prok synonym: "octopine breakdown to proline" EXACT [] synonym: "octopine degradation to proline" EXACT [] xref: MetaCyc:OCTOPINEDEG-PWY is_a: GO:0006560 ! proline metabolic process is_a: GO:0019469 ! octopine catabolic process [Term] id: GO:0042461 name: photoreceptor cell development namespace: biological_process alt_id: GO:0046531 def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] synonym: "photoreceptor morphogenesis" EXACT [] is_a: GO:0048666 ! neuron development relationship: part_of GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0042462 name: eye photoreceptor cell development namespace: biological_process def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981] is_a: GO:0042461 ! photoreceptor cell development relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation [Term] id: GO:0042463 name: ocellus photoreceptor cell development namespace: biological_process alt_id: GO:0001749 def: "Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." [GOC:jl, ISBN:0192800981, PMID:11542766] synonym: "non-eye photoreceptor development" BROAD [] is_a: GO:0042461 ! photoreceptor cell development relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation [Term] id: GO:0042464 name: dosage compensation, by hypoactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361] is_a: GO:0007549 ! dosage compensation [Term] id: GO:0042465 name: kinesis namespace: biological_process def: "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." [GOC:jl, ISBN:0192801023] xref: Wikipedia:Kinesis is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0042466 name: chemokinesis namespace: biological_process def: "A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis)." [GOC:jl, PMID:2073411] xref: Wikipedia:Chemokinesis is_a: GO:0042465 ! kinesis [Term] id: GO:0042467 name: orthokinesis namespace: biological_process def: "The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased." [GOC:jl, PMID:8207088] is_a: GO:0042465 ! kinesis [Term] id: GO:0042468 name: klinokinesis namespace: biological_process def: "The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered." [GOC:jl, PMID:2790068] is_a: GO:0042465 ! kinesis [Term] id: GO:0042469 name: versicolorin reductase activity namespace: molecular_function def: "Catalysis of the reduction of versicolorin A to sterigmatocystin." [PMID:1339261] xref: EC:1.1.-.- is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0042470 name: melanosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] xref: Wikipedia:Melanosome is_a: GO:0048770 ! pigment granule [Term] id: GO:0042471 name: ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] synonym: "hearing organ morphogenesis" EXACT [] is_a: GO:0048562 ! embryonic organ morphogenesis relationship: part_of GO:0043583 ! ear development [Term] id: GO:0042472 name: inner ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042471 ! ear morphogenesis relationship: part_of GO:0048839 ! inner ear development [Term] id: GO:0042473 name: outer ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull." [GOC:jl, ISBN:0192801023] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042471 ! ear morphogenesis [Term] id: GO:0042474 name: middle ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)." [GOC:jl, ISBN:0192801023] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042471 ! ear morphogenesis [Term] id: GO:0042475 name: odontogenesis of dentine-containing tooth namespace: biological_process def: "The process whose specific outcome is the progression of a dentine-containing tooth over time, from its formation to the mature structure. A dentine-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and are composed mainly of dentine, a dense calcified substance, covered by a layer of enamel." [GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794] synonym: "odontogenesis of dentin-containing tooth" EXACT [GOC:mah] synonym: "odontogenesis of dentine-containing teeth" EXACT [] synonym: "odontogeny" BROAD [] synonym: "odontosis" BROAD [] synonym: "tooth development" BROAD [] is_a: GO:0042476 ! odontogenesis [Term] id: GO:0042476 name: odontogenesis namespace: biological_process alt_id: GO:0042477 def: "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah] synonym: "odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "odontogeny" EXACT [] synonym: "odontosis" EXACT [] synonym: "tooth development" EXACT [] xref: Wikipedia:Odontogenesis is_a: GO:0009887 ! organ morphogenesis [Term] id: GO:0042478 name: regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "regulation of eye photoreceptor development" EXACT [] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0042462 ! eye photoreceptor cell development [Term] id: GO:0042479 name: positive regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "activation of eye photoreceptor cell development" NARROW [] synonym: "positive regulation of eye photoreceptor development" EXACT [] synonym: "stimulation of eye photoreceptor cell development" NARROW [] synonym: "up regulation of eye photoreceptor cell development" EXACT [] synonym: "up-regulation of eye photoreceptor cell development" EXACT [] synonym: "upregulation of eye photoreceptor cell development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0042478 ! regulation of eye photoreceptor cell development relationship: positively_regulates GO:0042462 ! eye photoreceptor cell development [Term] id: GO:0042480 name: negative regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "down regulation of eye photoreceptor cell development" EXACT [] synonym: "down-regulation of eye photoreceptor cell development" EXACT [] synonym: "downregulation of eye photoreceptor cell development" EXACT [] synonym: "inhibition of eye photoreceptor cell development" NARROW [] synonym: "negative regulation of eye photoreceptor development" EXACT [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0042478 ! regulation of eye photoreceptor cell development relationship: negatively_regulates GO:0042462 ! eye photoreceptor cell development [Term] id: GO:0042481 name: regulation of odontogenesis namespace: biological_process alt_id: GO:0042484 def: "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "regulation of tooth development" EXACT [] is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0042476 ! odontogenesis [Term] id: GO:0042482 name: positive regulation of odontogenesis namespace: biological_process alt_id: GO:0042485 def: "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "activation of odontogenesis" NARROW [] synonym: "positive regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "positive regulation of tooth development" EXACT [] synonym: "stimulation of odontogenesis" NARROW [] synonym: "up regulation of odontogenesis" EXACT [] synonym: "up-regulation of odontogenesis" EXACT [] synonym: "upregulation of odontogenesis" EXACT [] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0042476 ! odontogenesis [Term] id: GO:0042483 name: negative regulation of odontogenesis namespace: biological_process alt_id: GO:0042486 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "down regulation of odontogenesis" EXACT [] synonym: "down-regulation of odontogenesis" EXACT [] synonym: "downregulation of odontogenesis" EXACT [] synonym: "inhibition of odontogenesis" NARROW [] synonym: "negative regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "negative regulation of tooth development" EXACT [] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0042476 ! odontogenesis [Term] id: GO:0042487 name: regulation of odontogenesis of dentine-containing tooth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, GOC:mtg_sensu, PMID:15355794] synonym: "regulation of odontogenesis of dentin-containing tooth" EXACT [GOC:mah] synonym: "regulation of odontogenesis of dentine-containing teeth" EXACT [] is_a: GO:0042481 ! regulation of odontogenesis relationship: regulates GO:0042475 ! odontogenesis of dentine-containing tooth [Term] id: GO:0042488 name: positive regulation of odontogenesis of dentine-containing tooth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [dictyBase_REF:2530 "DictyBase paper repository", GOC:jl, PMID:15355794] synonym: "activation of odontogenesis" BROAD [] synonym: "positive regulation of odontogenesis of dentin-containing tooth" EXACT [GOC:mah] synonym: "positive regulation of odontogenesis of dentine-containing teeth" EXACT [] synonym: "stimulation of odontogenesis" BROAD [] synonym: "up regulation of odontogenesis" BROAD [] synonym: "up-regulation of odontogenesis" BROAD [] synonym: "upregulation of odontogenesis" BROAD [] is_a: GO:0042482 ! positive regulation of odontogenesis is_a: GO:0042487 ! regulation of odontogenesis of dentine-containing tooth relationship: positively_regulates GO:0042475 ! odontogenesis of dentine-containing tooth [Term] id: GO:0042489 name: negative regulation of odontogenesis of dentine-containing tooth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." [GOC:jl, GOC:mtg_sensu, PMID:15355794] synonym: "down regulation of odontogenesis" BROAD [] synonym: "down-regulation of odontogenesis" BROAD [] synonym: "downregulation of odontogenesis" BROAD [] synonym: "inhibition of odontogenesis" BROAD [] synonym: "negative regulation of odontogenesis" BROAD [] synonym: "negative regulation of odontogenesis of dentin-containing tooth" EXACT [GOC:mah] synonym: "negative regulation of odontogenesis of dentine-containing teeth" EXACT [] is_a: GO:0042483 ! negative regulation of odontogenesis is_a: GO:0042487 ! regulation of odontogenesis of dentine-containing tooth relationship: negatively_regulates GO:0042475 ! odontogenesis of dentine-containing tooth [Term] id: GO:0042490 name: mechanoreceptor differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [CL:0000199, GOC:jl] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0042491 name: auditory receptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell." [CL:0000201, GOC:jl] comment: Note that this term refers to the mechanosensory hair cells of the inner ear. synonym: "auditory hair cell differentiation" EXACT [] is_a: GO:0060113 ! inner ear receptor cell differentiation [Term] id: GO:0042492 name: gamma-delta T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex." [CL:0000798, GOC:jl] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta T cell development" RELATED [GOC:add] synonym: "gamma-delta T lymphocyte differentiation" EXACT [] synonym: "gamma-delta T-cell differentiation" EXACT [] synonym: "gamma-delta T-lymphocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0042493 name: response to drug namespace: biological_process alt_id: GO:0017035 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl] subset: goslim_candida subset: gosubset_prok synonym: "drug resistance" RELATED [] synonym: "drug susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0042494 name: detection of bacterial lipoprotein namespace: biological_process def: "The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222] synonym: "detection of BLP" RELATED [] synonym: "detection of Lpp" RELATED [] synonym: "perception of bacterial lipoprotein" RELATED [] synonym: "perception of BLP" RELATED [] synonym: "perception of Lpp" RELATED [] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0032493 ! response to bacterial lipoprotein relationship: part_of GO:0016045 ! detection of bacterium [Term] id: GO:0042495 name: detection of triacyl bacterial lipopeptide namespace: biological_process def: "The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "detection of triacylated bacterial lipoprotein" EXACT [GOC:add] synonym: "perception of triacylated bacterial lipopeptide" RELATED [GOC:add] synonym: "perception of triacylated bacterial lipoprotein" RELATED [GOC:curators] is_a: GO:0070340 ! detection of bacterial lipopeptide is_a: GO:0071725 ! response to triacyl bacterial lipopeptide [Term] id: GO:0042496 name: detection of diacyl bacterial lipopeptide namespace: biological_process def: "The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "detection of diacylated bacterial lipoprotein" EXACT [GOC:add] synonym: "perception of diacylated bacterial lipopeptide" RELATED [GOC:add] synonym: "perception of diacylated bacterial lipoprotein" RELATED [GOC:curators] is_a: GO:0070340 ! detection of bacterial lipopeptide is_a: GO:0071724 ! response to diacyl bacterial lipopeptide [Term] id: GO:0042497 name: triacyl lipopeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "bacterial triacyl lipopeptide binding" NARROW [GOC:add] synonym: "bacterial triacyl lipoprotein binding" RELATED [GOC:add] synonym: "triacylated lipopeptide binding" EXACT [] is_a: GO:0071723 ! lipopeptide binding [Term] id: GO:0042498 name: diacyl lipopeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "bacterial diacyl lipopeptide binding" NARROW [GOC:add] synonym: "bacterial diacyl lipoprotein binding" RELATED [GOC:add] synonym: "diacylated lipopeptide binding" EXACT [] is_a: GO:0071723 ! lipopeptide binding [Term] id: GO:0042499 name: signal peptide peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416] comment: This term was made obsolete because it represents a gene product. synonym: "SPP" EXACT [] xref: EC:3.4.23.- is_obsolete: true replaced_by: GO:0042500 [Term] id: GO:0042500 name: aspartic endopeptidase activity, intramembrane cleaving namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases. xref: EC:3.4.23.- is_a: GO:0004190 ! aspartic-type endopeptidase activity [Term] id: GO:0042501 name: serine phosphorylation of STAT protein namespace: biological_process def: "The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] is_a: GO:0018105 ! peptidyl-serine phosphorylation relationship: part_of GO:0046425 ! regulation of JAK-STAT cascade [Term] id: GO:0042502 name: tyrosine phosphorylation of Stat2 protein namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594] is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042503 name: tyrosine phosphorylation of Stat3 protein namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647] is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042504 name: tyrosine phosphorylation of Stat4 protein namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647] is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042505 name: tyrosine phosphorylation of Stat6 protein namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647] is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042506 name: tyrosine phosphorylation of Stat5 protein namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647] is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042507 name: tyrosine phosphorylation of Stat7 protein namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647] is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042508 name: tyrosine phosphorylation of Stat1 protein namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594] is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042509 name: regulation of tyrosine phosphorylation of STAT protein namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] is_a: GO:0046425 ! regulation of JAK-STAT cascade is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation relationship: regulates GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042510 name: regulation of tyrosine phosphorylation of Stat1 protein namespace: biological_process def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein relationship: regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein [Term] id: GO:0042511 name: positive regulation of tyrosine phosphorylation of Stat1 protein namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594] synonym: "activation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat1 protein" EXACT [] synonym: "up-regulation of tyrosine phosphorylation of Stat1 protein" EXACT [] synonym: "upregulation of tyrosine phosphorylation of Stat1 protein" EXACT [] is_a: GO:0042510 ! regulation of tyrosine phosphorylation of Stat1 protein is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein relationship: positively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein [Term] id: GO:0042512 name: negative regulation of tyrosine phosphorylation of Stat1 protein namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594] synonym: "down regulation of tyrosine phosphorylation of Stat1 protein" EXACT [] synonym: "down-regulation of tyrosine phosphorylation of Stat1 protein" EXACT [] synonym: "downregulation of tyrosine phosphorylation of Stat1 protein" EXACT [] synonym: "inhibition of tyrosine phosphorylation of Stat1 protein" NARROW [] is_a: GO:0042510 ! regulation of tyrosine phosphorylation of Stat1 protein is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein relationship: negatively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein [Term] id: GO:0042513 name: regulation of tyrosine phosphorylation of Stat2 protein namespace: biological_process def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein relationship: regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein [Term] id: GO:0042514 name: negative regulation of tyrosine phosphorylation of Stat2 protein namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594] synonym: "down regulation of tyrosine phosphorylation of Stat2 protein" EXACT [] synonym: "down-regulation of tyrosine phosphorylation of Stat2 protein" EXACT [] synonym: "downregulation of tyrosine phosphorylation of Stat2 protein" EXACT [] synonym: "inhibition of tyrosine phosphorylation of Stat2 protein" NARROW [] is_a: GO:0042513 ! regulation of tyrosine phosphorylation of Stat2 protein is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein relationship: negatively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein [Term] id: GO:0042515 name: positive regulation of tyrosine phosphorylation of Stat2 protein namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594] synonym: "activation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat2 protein" EXACT [] synonym: "up-regulation of tyrosine phosphorylation of Stat2 protein" EXACT [] synonym: "upregulation of tyrosine phosphorylation of Stat2 protein" EXACT [] is_a: GO:0042513 ! regulation of tyrosine phosphorylation of Stat2 protein is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein relationship: positively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein [Term] id: GO:0042516 name: regulation of tyrosine phosphorylation of Stat3 protein namespace: biological_process def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein relationship: regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein [Term] id: GO:0042517 name: positive regulation of tyrosine phosphorylation of Stat3 protein namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647] synonym: "activation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat3 protein" EXACT [] synonym: "up-regulation of tyrosine phosphorylation of Stat3 protein" EXACT [] synonym: "upregulation of tyrosine phosphorylation of Stat3 protein" EXACT [] is_a: GO:0042516 ! regulation of tyrosine phosphorylation of Stat3 protein is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein relationship: positively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein [Term] id: GO:0042518 name: negative regulation of tyrosine phosphorylation of Stat3 protein namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647] synonym: "down regulation of tyrosine phosphorylation of Stat3 protein" EXACT [] synonym: "down-regulation of tyrosine phosphorylation of Stat3 protein" EXACT [] synonym: "downregulation of tyrosine phosphorylation of Stat3 protein" EXACT [] synonym: "inhibition of tyrosine phosphorylation of Stat3 protein" NARROW [] is_a: GO:0042516 ! regulation of tyrosine phosphorylation of Stat3 protein is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein relationship: negatively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein [Term] id: GO:0042519 name: regulation of tyrosine phosphorylation of Stat4 protein namespace: biological_process def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein relationship: regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein [Term] id: GO:0042520 name: positive regulation of tyrosine phosphorylation of Stat4 protein namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647] synonym: "activation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat4 protein" EXACT [] synonym: "up-regulation of tyrosine phosphorylation of Stat4 protein" EXACT [] synonym: "upregulation of tyrosine phosphorylation of Stat4 protein" EXACT [] is_a: GO:0042519 ! regulation of tyrosine phosphorylation of Stat4 protein is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein relationship: positively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein [Term] id: GO:0042521 name: negative regulation of tyrosine phosphorylation of Stat4 protein namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647] synonym: "down regulation of tyrosine phosphorylation of Stat4 protein" EXACT [] synonym: "down-regulation of tyrosine phosphorylation of Stat4 protein" EXACT [] synonym: "downregulation of tyrosine phosphorylation of Stat4 protein" EXACT [] synonym: "inhibition of tyrosine phosphorylation of Stat4 protein" NARROW [] is_a: GO:0042519 ! regulation of tyrosine phosphorylation of Stat4 protein is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein relationship: negatively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein [Term] id: GO:0042522 name: regulation of tyrosine phosphorylation of Stat5 protein namespace: biological_process def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein relationship: regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein [Term] id: GO:0042523 name: positive regulation of tyrosine phosphorylation of Stat5 protein namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647] synonym: "activation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat5 protein" EXACT [] synonym: "up-regulation of tyrosine phosphorylation of Stat5 protein" EXACT [] synonym: "upregulation of tyrosine phosphorylation of Stat5 protein" EXACT [] is_a: GO:0042522 ! regulation of tyrosine phosphorylation of Stat5 protein is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein relationship: positively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein [Term] id: GO:0042524 name: negative regulation of tyrosine phosphorylation of Stat5 protein namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647] synonym: "down regulation of tyrosine phosphorylation of Stat5 protein" EXACT [] synonym: "down-regulation of tyrosine phosphorylation of Stat5 protein" EXACT [] synonym: "downregulation of tyrosine phosphorylation of Stat5 protein" EXACT [] synonym: "inhibition of tyrosine phosphorylation of Stat5 protein" NARROW [] is_a: GO:0042522 ! regulation of tyrosine phosphorylation of Stat5 protein is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein relationship: negatively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein [Term] id: GO:0042525 name: regulation of tyrosine phosphorylation of Stat6 protein namespace: biological_process def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein relationship: regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein [Term] id: GO:0042526 name: positive regulation of tyrosine phosphorylation of Stat6 protein namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647] synonym: "activation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat6 protein" EXACT [] synonym: "up-regulation of tyrosine phosphorylation of Stat6 protein" EXACT [] synonym: "upregulation of tyrosine phosphorylation of Stat6 protein" EXACT [] is_a: GO:0042525 ! regulation of tyrosine phosphorylation of Stat6 protein is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein relationship: positively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein [Term] id: GO:0042527 name: negative regulation of tyrosine phosphorylation of Stat6 protein namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647] synonym: "down regulation of tyrosine phosphorylation of Stat6 protein" EXACT [] synonym: "down-regulation of tyrosine phosphorylation of Stat6 protein" EXACT [] synonym: "downregulation of tyrosine phosphorylation of Stat6 protein" EXACT [] synonym: "inhibition of tyrosine phosphorylation of Stat6 protein" NARROW [] is_a: GO:0042525 ! regulation of tyrosine phosphorylation of Stat6 protein is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein relationship: negatively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein [Term] id: GO:0042528 name: regulation of tyrosine phosphorylation of Stat7 protein namespace: biological_process def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein relationship: regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein [Term] id: GO:0042529 name: positive regulation of tyrosine phosphorylation of Stat7 protein namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647] synonym: "activation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat7 protein" EXACT [] synonym: "up-regulation of tyrosine phosphorylation of Stat7 protein" EXACT [] synonym: "upregulation of tyrosine phosphorylation of Stat7 protein" EXACT [] is_a: GO:0042528 ! regulation of tyrosine phosphorylation of Stat7 protein is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein relationship: positively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein [Term] id: GO:0042530 name: negative regulation of tyrosine phosphorylation of Stat7 protein namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647] synonym: "down regulation of tyrosine phosphorylation of Stat7 protein" EXACT [] synonym: "down-regulation of tyrosine phosphorylation of Stat7 protein" EXACT [] synonym: "downregulation of tyrosine phosphorylation of Stat7 protein" EXACT [] synonym: "inhibition of tyrosine phosphorylation of Stat7 protein" NARROW [] is_a: GO:0042528 ! regulation of tyrosine phosphorylation of Stat7 protein is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein relationship: negatively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein [Term] id: GO:0042531 name: positive regulation of tyrosine phosphorylation of STAT protein namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] synonym: "activation of tyrosine phosphorylation of STAT protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of STAT protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "up-regulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "upregulation of tyrosine phosphorylation of STAT protein" EXACT [] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein is_a: GO:0046427 ! positive regulation of JAK-STAT cascade is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation relationship: positively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042532 name: negative regulation of tyrosine phosphorylation of STAT protein namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] synonym: "down regulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "down-regulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "downregulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "inhibition of tyrosine phosphorylation of STAT protein" NARROW [] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein is_a: GO:0046426 ! negative regulation of JAK-STAT cascade is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation relationship: negatively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042533 name: tumor necrosis factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "TNF alpha biosynthesis" EXACT [] synonym: "TNF alpha biosynthetic process" EXACT [] synonym: "TNF biosynthesis" EXACT [] synonym: "TNF biosynthetic process" EXACT [] synonym: "TNF-alpha biosynthesis" EXACT [] synonym: "TNF-alpha biosynthetic process" EXACT [] synonym: "Tumor Necrosis Factor alpha biosynthesis" EXACT [] synonym: "Tumor Necrosis Factor alpha biosynthetic process" EXACT [] synonym: "tumor necrosis factor anabolism" EXACT [] synonym: "tumor necrosis factor biosynthesis" EXACT [] synonym: "tumor necrosis factor formation" EXACT [] synonym: "tumor necrosis factor synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032640 ! tumor necrosis factor production [Term] id: GO:0042534 name: regulation of tumor necrosis factor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "regulation of TNF alpha biosynthesis" EXACT [] synonym: "regulation of TNF alpha biosynthetic process" EXACT [] synonym: "regulation of TNF biosynthesis" EXACT [] synonym: "regulation of TNF biosynthetic process" EXACT [] synonym: "regulation of TNF-alpha biosynthesis" EXACT [] synonym: "regulation of TNF-alpha biosynthetic process" EXACT [] synonym: "regulation of tumor necrosis factor anabolism" EXACT [] synonym: "regulation of tumor necrosis factor biosynthesis" EXACT [] synonym: "regulation of tumor necrosis factor formation" EXACT [] synonym: "regulation of tumor necrosis factor synthesis" EXACT [] synonym: "regulation of tumor necrosis factor-alpha biosynthesis" EXACT [] synonym: "regulation of tumor necrosis factor-alpha biosynthetic process" EXACT [] is_a: GO:0032680 ! regulation of tumor necrosis factor production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042533 ! tumor necrosis factor biosynthetic process [Term] id: GO:0042535 name: positive regulation of tumor necrosis factor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "activation of tumor necrosis factor biosynthetic process" NARROW [] synonym: "positive regulation of TNF alpha biosynthesis" EXACT [] synonym: "positive regulation of TNF alpha biosynthetic process" EXACT [] synonym: "positive regulation of TNF biosynthesis" EXACT [] synonym: "positive regulation of TNF biosynthetic process" EXACT [] synonym: "positive regulation of TNF-alpha biosynthesis" EXACT [] synonym: "positive regulation of TNF-alpha biosynthetic process" EXACT [] synonym: "positive regulation of tumor necrosis factor anabolism" EXACT [] synonym: "positive regulation of tumor necrosis factor biosynthesis" EXACT [] synonym: "positive regulation of tumor necrosis factor formation" EXACT [] synonym: "positive regulation of tumor necrosis factor synthesis" EXACT [] synonym: "positive regulation of tumor necrosis factor-alpha biosynthesis" EXACT [] synonym: "positive regulation of tumor necrosis factor-alpha biosynthetic process" EXACT [] synonym: "stimulation of tumor necrosis factor biosynthetic process" NARROW [] synonym: "up regulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "up-regulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "upregulation of tumor necrosis factor biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process relationship: positively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process [Term] id: GO:0042536 name: negative regulation of tumor necrosis factor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "down regulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "down-regulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "downregulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "inhibition of tumor necrosis factor biosynthetic process" NARROW [] synonym: "negative regulation of TNF alpha biosynthesis" EXACT [] synonym: "negative regulation of TNF alpha biosynthetic process" EXACT [] synonym: "negative regulation of TNF biosynthesis" EXACT [] synonym: "negative regulation of TNF biosynthetic process" EXACT [] synonym: "negative regulation of TNF-alpha biosynthesis" EXACT [] synonym: "negative regulation of TNF-alpha biosynthetic process" EXACT [] synonym: "negative regulation of tumor necrosis factor anabolism" EXACT [] synonym: "negative regulation of tumor necrosis factor biosynthesis" EXACT [] synonym: "negative regulation of tumor necrosis factor formation" EXACT [] synonym: "negative regulation of tumor necrosis factor synthesis" EXACT [] synonym: "negative regulation of tumor necrosis factor-alpha biosynthesis" EXACT [] synonym: "negative regulation of tumor necrosis factor-alpha biosynthetic process" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process relationship: negatively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process [Term] id: GO:0042537 name: benzene-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives." [CHEBI:22712, GOC:jl] subset: gosubset_prok synonym: "benzene and derivative metabolic process" EXACT [GOC:curators] synonym: "benzene and derivative metabolism" EXACT [] synonym: "benzene-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0006725 ! cellular aromatic compound metabolic process [Term] id: GO:0042538 name: hyperosmotic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] synonym: "response to hyperosmotic salt stress" EXACT [] synonym: "salt tolerance" RELATED [] is_a: GO:0006972 ! hyperosmotic response is_a: GO:0009651 ! response to salt stress [Term] id: GO:0042539 name: hypotonic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] synonym: "response to hypotonic salt stress" EXACT [] is_a: GO:0006971 ! hypotonic response is_a: GO:0009651 ! response to salt stress [Term] id: GO:0042540 name: hemoglobin catabolic process namespace: biological_process alt_id: GO:0020029 def: "The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids." [CHEBI:35143, GOC:jl, GOC:mb] comment: Note that 'hydrolysis' is actually a reaction rather than a process. The synonym 'hemoglobin hydrolysis' was the text string associated with the secondary ID GO:0020029, which was retained because its definition did describe a process. synonym: "haemoglobin catabolic process" EXACT [] synonym: "haemoglobin catabolism" EXACT [] synonym: "haemoglobin hydrolysis" NARROW [] synonym: "hemoglobin breakdown" EXACT [] synonym: "hemoglobin catabolism" EXACT [] synonym: "hemoglobin degradation" EXACT [] synonym: "hemoglobin hydrolysis" NARROW [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0020027 ! hemoglobin metabolic process [Term] id: GO:0042541 name: hemoglobin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [CHEBI:35143, GOC:jl] synonym: "haemoglobin biosynthesis" EXACT [] synonym: "haemoglobin biosynthetic process" EXACT [] synonym: "hemoglobin anabolism" EXACT [] synonym: "hemoglobin biosynthesis" EXACT [] synonym: "hemoglobin formation" EXACT [] synonym: "hemoglobin synthesis" EXACT [] is_a: GO:0020027 ! hemoglobin metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:0042542 name: response to hydrogen peroxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species [Term] id: GO:0042543 name: protein N-linked glycosylation via arginine namespace: biological_process def: "The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine." [RESID:AA0327] subset: gosubset_prok synonym: "protein amino acid N-linked glycosylation via arginine" EXACT [GOC:bf] xref: RESID:AA0327 is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0042544 name: melibiose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "melibiose anabolism" EXACT [] synonym: "melibiose biosynthesis" EXACT [] synonym: "melibiose formation" EXACT [] synonym: "melibiose synthesis" EXACT [] is_a: GO:0005994 ! melibiose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0042545 name: cell wall modification namespace: biological_process def: "The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly." [GOC:jl] subset: gosubset_prok is_a: GO:0071555 ! cell wall organization [Term] id: GO:0042546 name: cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah, GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cell wall assembly" NARROW [] is_a: GO:0070882 ! cellular cell wall organization or biogenesis is_a: GO:0071843 ! cellular component biogenesis at cellular level [Term] id: GO:0042547 name: cell wall modification involved in multidimensional cell growth namespace: biological_process def: "The series of events resulting in chemical or structural changes to existing cell walls and contribute to multidimensional cell growth." [GOC:dph, GOC:jl, GOC:tb] subset: gosubset_prok synonym: "cell wall modification during cell expansion" EXACT [] synonym: "cell wall modification during multidimensional cell growth" RELATED [GOC:dph, GOC:tb] is_a: GO:0042545 ! cell wall modification relationship: part_of GO:0009825 ! multidimensional cell growth [Term] id: GO:0042548 name: regulation of photosynthesis, light reaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl] is_a: GO:0010109 ! regulation of photosynthesis is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy relationship: regulates GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0042549 name: photosystem II stabilization namespace: biological_process def: "The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators] is_a: GO:0042548 ! regulation of photosynthesis, light reaction [Term] id: GO:0042550 name: photosystem I stabilization namespace: biological_process def: "The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators] is_a: GO:0042548 ! regulation of photosynthesis, light reaction [Term] id: GO:0042551 name: neuron maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl] is_a: GO:0048469 ! cell maturation relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0042552 name: myelination namespace: biological_process def: "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah] xref: Wikipedia:Myelin is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0042554 name: superoxide anion generation namespace: biological_process def: "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750] subset: gosubset_prok synonym: "superoxide release" EXACT [GOC:hjd, GOC:mah] is_a: GO:0006801 ! superoxide metabolic process [Term] id: GO:0042555 name: MCM complex namespace: cellular_component def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] synonym: "mini-chromosome maintenance complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0042556 name: eukaryotic elongation factor-2 kinase regulator activity namespace: molecular_function def: "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] synonym: "eEF-2 kinase regulator" EXACT [] xref: EC:2.7.1.- is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0042557 name: eukaryotic elongation factor-2 kinase activator activity namespace: molecular_function def: "Increases the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] synonym: "eEF-2 kinase activator" EXACT [] xref: EC:2.7.1.- is_a: GO:0030295 ! protein kinase activator activity is_a: GO:0042556 ! eukaryotic elongation factor-2 kinase regulator activity [Term] id: GO:0042558 name: pteridine-containing compound metabolic process namespace: biological_process alt_id: GO:0019721 def: "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pteridine and derivative metabolic process" EXACT [GOC:curators] synonym: "pteridine and derivative metabolism" EXACT [GOC:curators] synonym: "pteridine-containing compound metabolism" EXACT [GOC:curators] synonym: "pterin metabolic process" NARROW [CHEBI:26375, GOC:curators] synonym: "pterin metabolism" NARROW [CHEBI:26375, GOC:curators] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0042559 name: pteridine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pteridine and derivative biosynthesis" EXACT [GOC:curators] synonym: "pteridine and derivative biosynthetic process" EXACT [GOC:curators] synonym: "pteridine-containing compound anabolism" EXACT [GOC:curators] synonym: "pteridine-containing compound biosynthesis" EXACT [GOC:curators] synonym: "pteridine-containing compound formation" EXACT [GOC:curators] synonym: "pteridine-containing compound synthesis" EXACT [GOC:curators] synonym: "pterin biosynthesis" NARROW [CHEBI:26375, GOC:curatos] synonym: "pterin biosynthetic process" NARROW [CHEBI:26375, GOC:curators] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042558 ! pteridine-containing compound metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0042560 name: pteridine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pteridine and derivative catabolic process" EXACT [GOC:curators] synonym: "pteridine and derivative catabolism" EXACT [GOC:curators] synonym: "pteridine-containing compound breakdown" EXACT [GOc:curators] synonym: "pteridine-containing compound catabolism" EXACT [GOC:curators] synonym: "pteridine-containing compound degradation" EXACT [GOC:curators] synonym: "pterin catabolic process" NARROW [CHEBI:26375, GOC:curators] synonym: "pterin catabolism" NARROW [CHEBI:26375, GOC:curators] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0042561 name: alpha-amyrin synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin." [GOC:jl, MetaCyc:RXN-8434, PMID:10848960] xref: MetaCyc:RXN-8434 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0042562 name: hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0042563 name: importin alpha-subunit nuclear export complex namespace: cellular_component def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134] is_a: GO:0031074 ! nucleocytoplasmic shuttling complex [Term] id: GO:0042564 name: NLS-dependent protein nuclear import complex namespace: cellular_component def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134] is_a: GO:0031074 ! nucleocytoplasmic shuttling complex [Term] id: GO:0042565 name: RNA nuclear export complex namespace: cellular_component def: "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123] is_a: GO:0031074 ! nucleocytoplasmic shuttling complex [Term] id: GO:0042566 name: hydrogenosome namespace: cellular_component def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569] subset: goslim_pir xref: Wikipedia:Hydrogenosome is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0042567 name: insulin-like growth factor ternary complex namespace: cellular_component def: "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] synonym: "IGF ternary complex" EXACT [] is_a: GO:0016942 ! insulin-like growth factor binding protein complex [Term] id: GO:0042568 name: insulin-like growth factor binary complex namespace: cellular_component def: "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] synonym: "IGF binary complex" EXACT [] is_a: GO:0016942 ! insulin-like growth factor binding protein complex [Term] id: GO:0042571 name: immunoglobulin complex, circulating namespace: cellular_component def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "antibody" EXACT [GOC:add] xref: Wikipedia:Antibody is_a: GO:0019814 ! immunoglobulin complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0042572 name: retinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] subset: gosubset_prok synonym: "retinol metabolism" EXACT [] synonym: "vitamin A1 alcohol metabolic process" EXACT [] synonym: "vitamin A1 alcohol metabolism" EXACT [] synonym: "vitamin A1 metabolic process" EXACT [] synonym: "vitamin A1 metabolism" EXACT [] xref: Wikipedia:Retinol is_a: GO:0001523 ! retinoid metabolic process is_a: GO:0006776 ! vitamin A metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0042573 name: retinoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "retinoic acid metabolism" EXACT [] synonym: "vitamin A1 acid metabolic process" EXACT [] synonym: "vitamin A1 acid metabolism" EXACT [] is_a: GO:0001523 ! retinoid metabolic process is_a: GO:0006776 ! vitamin A metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0042574 name: retinal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [CHEBI:15035, GOC:curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "retinal metabolism" EXACT [] synonym: "retinaldehyde metabolic process" EXACT [] synonym: "retinaldehyde metabolism" EXACT [] is_a: GO:0001523 ! retinoid metabolic process is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006776 ! vitamin A metabolic process is_a: GO:0043288 ! apocarotenoid metabolic process [Term] id: GO:0042575 name: DNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0042576 name: aspartyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok xref: EC:3.4.11.21 xref: MetaCyc:3.4.11.21-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0042577 name: lipid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0042578 name: phosphoric ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] subset: gosubset_prok xref: EC:3.1.-.- is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0042579 name: microbody namespace: cellular_component def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir xref: Wikipedia:Microbody is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0042580 name: mannosome namespace: cellular_component def: "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531] is_a: GO:0005777 ! peroxisome [Term] id: GO:0042581 name: specific granule namespace: cellular_component def: "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:7334549] synonym: "secondary granule" EXACT [] xref: Wikipedia:Specific_granule is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0042582 name: azurophil granule namespace: cellular_component def: "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:jl, PMID:17152095] synonym: "primary granule" EXACT [] is_a: GO:0005766 ! primary lysosome is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0042583 name: chromaffin granule namespace: cellular_component def: "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, PMID:19158310, PMID:1961743] is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0042584 name: chromaffin granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042583 ! chromaffin granule [Term] id: GO:0042585 name: germinal vesicle namespace: cellular_component def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837] synonym: "primary oocyte nucleus" EXACT [] is_a: GO:0001674 ! female germ cell nucleus [Term] id: GO:0042586 name: peptide deformylase activity namespace: molecular_function def: "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl] subset: gosubset_prok synonym: "formyl-L-methionyl peptide amidohydrolase activity" EXACT [EC:3.5.1.88] synonym: "PDF activity" EXACT [EC:3.5.1.88] synonym: "polypeptide deformylase activity" EXACT [EC:3.5.1.88] xref: EC:3.5.1.88 xref: MetaCyc:3.5.1.88-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0042587 name: glycogen granule namespace: cellular_component def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, http://148.216.10.83/cellbio/the_mi19.gif, PMID:12179957] synonym: "glycogen particle" EXACT [] xref: NIF_Subcellular:sao1081228141 is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0042588 name: zymogen granule namespace: cellular_component def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0042589 name: zymogen granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042588 ! zymogen granule [Term] id: GO:0042590 name: antigen processing and presentation of exogenous peptide antigen via MHC class I namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "antigen presentation, exogenous antigen via major histocompatibility complex class I" EXACT [] synonym: "antigen presentation, exogenous antigen via MHC class I" EXACT [] synonym: "cross presentation" BROAD [] synonym: "cross priming" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "cross-priming" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen [Term] id: GO:0042592 name: homeostatic process namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] subset: goslim_generic subset: gosubset_prok synonym: "homeostasis" RELATED [] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0042593 name: glucose homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] subset: gosubset_prok is_a: GO:0033500 ! carbohydrate homeostasis [Term] id: GO:0042594 name: response to starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006950 ! response to stress is_a: GO:0031667 ! response to nutrient levels [Term] id: GO:0042595 name: behavioral response to starvation namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] synonym: "behavioural response to starvation" EXACT [] is_a: GO:0042594 ! response to starvation [Term] id: GO:0042596 name: fear response namespace: biological_process alt_id: GO:0001663 def: "The response of an organism to a perceived external threat." [GOC:go_curators] synonym: "physiological fear response" EXACT [] is_a: GO:0033555 ! multicellular organismal response to stress [Term] id: GO:0042597 name: periplasmic space namespace: cellular_component alt_id: GO:0005620 def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi)." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "periplasm" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0042598 name: vesicular fraction namespace: cellular_component def: "Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: gosubset_prok is_a: GO:0005624 ! membrane fraction [Term] id: GO:0042599 name: lamellar body namespace: cellular_component def: "A membrane-bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:jl, PMID:12243725] synonym: "keratinosome" EXACT [] synonym: "lamellar granule" EXACT [] synonym: "membrane-coating granule" EXACT [] synonym: "Odland body" EXACT [] xref: NIF_Subcellular:sao1379604862 is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0042600 name: chorion namespace: cellular_component def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO. subset: goslim_pir is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0042601 name: endospore-forming forespore namespace: cellular_component def: "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions." [GOC:jl, GOC:mtg_sensu, ISBN:0697286029] subset: gosubset_prok is_a: GO:0042763 ! intracellular immature spore [Term] id: GO:0042602 name: flavin reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + H+." [EC:1.5.1.30] subset: gosubset_prok synonym: "FMN reductase (NADPH) activity" EXACT [EC:1.5.1.30] synonym: "NADPH dehydrogenase (flavin) activity" EXACT [EC:1.5.1.30] synonym: "NADPH-dependent FMN reductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH-flavin oxidoreductase activity" EXACT [] synonym: "NADPH-flavin reductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH-FMN reductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH-specific FMN reductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH2 dehydrogenase (flavin)" EXACT [EC:1.5.1.30] synonym: "NADPH2:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH:flavin oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "reduced-riboflavin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.30] synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.30] synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.30] xref: EC:1.5.1.30 xref: MetaCyc:NADPH-DEHYDROGENASE-FLAVIN-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0042603 name: capsule namespace: cellular_component alt_id: GO:0030113 alt_id: GO:0042604 def: "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and can not be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication." [GOC:mlg] subset: gosubset_prok xref: Wikipedia:Capsule_(microbiology) is_a: GO:0030112 ! glycocalyx [Term] id: GO:0042605 name: peptide antigen binding namespace: molecular_function alt_id: GO:0042606 alt_id: GO:0042607 def: "Interacting selectively and non-covalently with an antigen peptide." [GOC:add, GOC:jl, GOC:rv] comment: Note that this term can be used to describe the binding of a peptide to an MHC molecule. synonym: "endogenous peptide antigen binding" NARROW [] synonym: "exogenous peptide antigen binding" NARROW [] is_a: GO:0003823 ! antigen binding is_a: GO:0042277 ! peptide binding [Term] id: GO:0042608 name: T cell receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl] synonym: "T lymphocyte receptor binding" EXACT [] synonym: "T-cell receptor binding" EXACT [] synonym: "T-lymphocyte receptor binding" EXACT [] synonym: "TCR binding" EXACT [] is_a: GO:0005102 ! receptor binding is_a: GO:0032403 ! protein complex binding [Term] id: GO:0042609 name: CD4 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages." [GOC:jl, MeSH:D015704] is_a: GO:0005102 ! receptor binding [Term] id: GO:0042610 name: CD8 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes." [GOC:jl, MeSH:D016827] is_a: GO:0005102 ! receptor binding [Term] id: GO:0042611 name: MHC protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149 "Fundamental Immunology", PMID:15928678, PMID:16153240] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0042612 name: MHC class I protein complex namespace: cellular_component def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149 "Fundamental Immunology"] comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'. is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0042613 name: MHC class II protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678] is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0042614 name: CD70 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD70, a receptor found on the surface of most activated B cells and some activated T cells." [GOC:jl, ISBN:0120781859] synonym: "CD27 receptor activity" RELATED [] synonym: "CD27L binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0042615 name: CD154 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with CD154, a receptor found on the surface of some activated lymphocytes." [GOC:jl, ISBN:0120781859] synonym: "CD40 receptor activity" RELATED [] synonym: "CD40L binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0042616 name: paclitaxel metabolic process namespace: biological_process def: "The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment." [CHEBI:45863, GOC:jl] subset: gosubset_prok synonym: "paclitaxel metabolism" EXACT [] synonym: "taxol metabolic process" NARROW [] synonym: "taxol metabolism" NARROW [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0042617 name: paclitaxel biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of paclitaxel, an alkaloid compound used as an anticancer treatment." [CHEBI:45863, GOC:jl] subset: gosubset_prok synonym: "paclitaxel anabolism" EXACT [] synonym: "paclitaxel biosynthesis" EXACT [] synonym: "paclitaxel formation" EXACT [] synonym: "paclitaxel synthesis" EXACT [] synonym: "taxol biosynthesis" NARROW [] synonym: "taxol biosynthetic process" NARROW [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042616 ! paclitaxel metabolic process [Term] id: GO:0042618 name: poly-hydroxybutyrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html] subset: gosubset_prok synonym: "PHB metabolic process" EXACT [] synonym: "PHB metabolism" EXACT [] synonym: "poly-hydroxybutyrate metabolism" EXACT [] is_a: GO:0019605 ! butyrate metabolic process [Term] id: GO:0042619 name: poly-hydroxybutyrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html] subset: gosubset_prok synonym: "PHB biosynthesis" EXACT [] synonym: "PHB biosynthetic process" EXACT [] synonym: "poly-hydroxybutyrate anabolism" EXACT [] synonym: "poly-hydroxybutyrate biosynthesis" EXACT [] synonym: "poly-hydroxybutyrate formation" EXACT [] synonym: "poly-hydroxybutyrate synthesis" EXACT [] is_a: GO:0042618 ! poly-hydroxybutyrate metabolic process is_a: GO:0046358 ! butyrate biosynthetic process [Term] id: GO:0042620 name: poly(3-hydroxyalkanoate) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580] subset: goslim_pir subset: gosubset_prok synonym: "PHA metabolic process" BROAD [] synonym: "PHA metabolism" BROAD [] synonym: "poly(3-hydroxyalkanoate) metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0042621 name: poly(3-hydroxyalkanoate) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580] subset: gosubset_prok synonym: "PHA biosynthesis" BROAD [] synonym: "PHA biosynthetic process" BROAD [] synonym: "poly(3-hydroxyalkanoate) anabolism" EXACT [] synonym: "poly(3-hydroxyalkanoate) biosynthesis" EXACT [] synonym: "poly(3-hydroxyalkanoate) formation" EXACT [] synonym: "poly(3-hydroxyalkanoate) synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0042620 ! poly(3-hydroxyalkanoate) metabolic process [Term] id: GO:0042622 name: photoreceptor outer segment membrane namespace: cellular_component def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." [GOC:jl] is_a: GO:0016020 ! membrane is_a: GO:0044441 ! cilium part relationship: part_of GO:0001750 ! photoreceptor outer segment [Term] id: GO:0042623 name: ATPase activity, coupled namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "ATP phosphohydrolase (polypeptide-unfolding)" NARROW [EC:3.6.4.9] synonym: "chaperonin" RELATED [EC:3.6.4.9] synonym: "chaperonin ATPase activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "nucleoplasmin ATPase activity" RELATED [] synonym: "peroxisome-assembly ATPase activity" RELATED [] is_a: GO:0016887 ! ATPase activity [Term] id: GO:0042624 name: ATPase activity, uncoupled namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction." [EC:3.6.1.3] subset: gosubset_prok synonym: "adenylpyrophosphatase activity" RELATED [EC:3.6.1.3] is_a: GO:0016887 ! ATPase activity [Term] id: GO:0042625 name: ATPase activity, coupled to transmembrane movement of ions namespace: molecular_function def: "Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [EC:3.6.1.3, GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0042626 name: ATPase activity, coupled to transmembrane movement of substances namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "ABC transporter" NARROW [] synonym: "ABC-type efflux permease activity" NARROW [] synonym: "ABC-type efflux porter activity" NARROW [] synonym: "ABC-type uptake permease activity" NARROW [] synonym: "ATP binding cassette transporter" NARROW [] synonym: "ATP-binding cassette (ABC) transporter activity" NARROW [] synonym: "ATP-binding cassette transporter" NARROW [] synonym: "mating pheromone exporter" NARROW [] xref: Reactome:78033 "ATPase activity, coupled to transmembrane movement of substances" is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity is_a: GO:0016820 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances is_a: GO:0043492 ! ATPase activity, coupled to movement of substances [Term] id: GO:0042627 name: chylomicron namespace: cellular_component def: "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, GOC:rl, http://biotech.icmb.utexas.edu/search/dict-search.html, PMID:10580165] xref: Wikipedia:Chylomicron is_a: GO:0034358 ! plasma lipoprotein particle [Term] id: GO:0042628 name: mating plug formation namespace: biological_process def: "The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males." [GOC:jl, http://www.wildcru.org/glossary/glossary.htm, http://www.wormatlas.org/glossaries/cglossary.htm, PMID:11267893] synonym: "copulatory plug biosynthesis" EXACT [] synonym: "copulatory plug deposition" EXACT [] synonym: "copulatory plug formation" EXACT [] synonym: "mating plug deposition" EXACT [] is_a: GO:0045297 ! post-mating behavior relationship: part_of GO:0007320 ! insemination [Term] id: GO:0042629 name: mast cell granule namespace: cellular_component def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215] is_a: GO:0005764 ! lysosome [Term] id: GO:0042630 name: behavioral response to water deprivation namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of deprivation of water." [GOC:jl] synonym: "behavioral response to drought" EXACT [] synonym: "behavioral response to thirst" EXACT [] synonym: "behavioural response to water deprivation" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009414 ! response to water deprivation [Term] id: GO:0042631 name: cellular response to water deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water." [GOC:go_curators] synonym: "cellular response to drought" EXACT [] is_a: GO:0009414 ! response to water deprivation is_a: GO:0031668 ! cellular response to extracellular stimulus is_a: GO:0033554 ! cellular response to stress is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0042632 name: cholesterol homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators] is_a: GO:0055092 ! sterol homeostasis [Term] id: GO:0042633 name: hair cycle namespace: biological_process def: "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507] is_a: GO:0042303 ! molting cycle [Term] id: GO:0042634 name: regulation of hair cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0042633 ! hair cycle [Term] id: GO:0042635 name: positive regulation of hair cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] synonym: "activation of hair cycle" NARROW [] synonym: "stimulation of hair cycle" NARROW [] synonym: "up regulation of hair cycle" EXACT [] synonym: "up-regulation of hair cycle" EXACT [] synonym: "upregulation of hair cycle" EXACT [] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0042633 ! hair cycle [Term] id: GO:0042636 name: negative regulation of hair cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] synonym: "down regulation of hair cycle" EXACT [] synonym: "down-regulation of hair cycle" EXACT [] synonym: "downregulation of hair cycle" EXACT [] synonym: "inhibition of hair cycle" NARROW [] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0042633 ! hair cycle [Term] id: GO:0042637 name: catagen namespace: biological_process def: "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced." [PMID:12535193] synonym: "hair regression" NARROW [] is_a: GO:0022405 ! hair cycle process relationship: part_of GO:0048820 ! hair follicle maturation [Term] id: GO:0042638 name: exogen namespace: biological_process def: "The shedding phase of the hair cycle." [PMID:12230507] synonym: "hair shedding" NARROW [] is_a: GO:0022405 ! hair cycle process relationship: part_of GO:0048820 ! hair follicle maturation [Term] id: GO:0042639 name: telogen namespace: biological_process def: "The resting phase of hair cycle." [PMID:12230507] synonym: "hair resting phase" NARROW [] is_a: GO:0022405 ! hair cycle process [Term] id: GO:0042640 name: anagen namespace: biological_process def: "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair." [PMID:12230507] synonym: "hair growth" NARROW [] is_a: GO:0022405 ! hair cycle process is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048820 ! hair follicle maturation [Term] id: GO:0042641 name: actomyosin namespace: cellular_component def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] synonym: "actomyosin complex" EXACT [] synonym: "actomyosin structure" EXACT [] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0042642 name: actomyosin, myosin complex part namespace: cellular_component def: "The myosin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] is_a: GO:0016459 ! myosin complex relationship: part_of GO:0042641 ! actomyosin [Term] id: GO:0042643 name: actomyosin, actin part namespace: cellular_component def: "The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] is_a: GO:0005884 ! actin filament relationship: part_of GO:0042641 ! actomyosin [Term] id: GO:0042644 name: chloroplast nucleoid namespace: cellular_component def: "The region of a chloroplast to which the DNA is confined." [GOC:jl] is_a: GO:0042646 ! plastid nucleoid is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0042645 name: mitochondrial nucleoid namespace: cellular_component def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0042646 name: plastid nucleoid namespace: cellular_component def: "The region of a plastid to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0044435 ! plastid part relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0042647 name: proplastid nucleoid namespace: cellular_component def: "The region of a proplastid to which the DNA is confined." [GOC:jl] is_a: GO:0042646 ! plastid nucleoid relationship: part_of GO:0009571 ! proplastid stroma [Term] id: GO:0042648 name: chloroplast chromosome namespace: cellular_component def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl] is_a: GO:0009508 ! plastid chromosome is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0042644 ! chloroplast nucleoid [Term] id: GO:0042649 name: prothylakoid namespace: cellular_component def: "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175] is_a: GO:0031976 ! plastid thylakoid relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0042650 name: prothylakoid membrane namespace: cellular_component def: "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175] is_a: GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0042649 ! prothylakoid [Term] id: GO:0042651 name: thylakoid membrane namespace: cellular_component def: "The pigmented membrane of any thylakoid." [GOC:jl] subset: gosubset_prok is_a: GO:0034357 ! photosynthetic membrane [Term] id: GO:0042652 name: mitochondrial respiratory chain complex I, peripheral segment namespace: cellular_component def: "The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556] synonym: "NADH dehydrogenase (ubiquinone) complex, peripheral segment" BROAD [] synonym: "NADH-Q oxidoreductase complex, peripheral segment" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I [Term] id: GO:0042653 name: mitochondrial respiratory chain complex I, membrane segment namespace: cellular_component def: "The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556] synonym: "NADH-Q oxidoreductase complex, membrane segment" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I [Term] id: GO:0042654 name: ecdysis-triggering hormone receptor activity namespace: molecular_function def: "Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma] synonym: "ecdysis-triggering hormone binding" NARROW [] synonym: "ETH receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0042562 ! hormone binding [Term] id: GO:0042655 name: activation of JNKKK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase kinase kinase activity in response to phosphorylation by a member of the MAP kinase kinase kinase kinase (MAPKKKK) family or another upstream kinase." [GOC:bf] synonym: "activation of JUN kinase kinase kinase activity" EXACT [] synonym: "positive regulation of JUNKKK activity" BROAD [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0042656 name: JUN kinase kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)." [GOC:bf] synonym: "JUNKKKK activity" EXACT [] is_a: GO:0008349 ! MAP kinase kinase kinase kinase activity [Term] id: GO:0042657 name: MHC class II protein binding, via lateral surface namespace: molecular_function def: "Interacting selectively and non-covalently with the lateral surface of major histocompatibility complex class II molecules." [GOC:jl] synonym: "major histocompatibility complex class II protein binding, via lateral surface" EXACT [] is_a: GO:0042289 ! MHC class II protein binding [Term] id: GO:0042658 name: MHC class II protein binding, via antigen binding groove namespace: molecular_function def: "Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules." [GOC:jl] synonym: "major histocompatibility complex class II protein binding, via antigen binding groove" EXACT [] is_a: GO:0042289 ! MHC class II protein binding relationship: part_of GO:0023026 ! MHC class II protein complex binding [Term] id: GO:0042659 name: regulation of cell fate specification namespace: biological_process def: "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators] is_a: GO:0010453 ! regulation of cell fate commitment relationship: regulates GO:0001708 ! cell fate specification [Term] id: GO:0042660 name: positive regulation of cell fate specification namespace: biological_process def: "Any process that activates or enables a cell to adopt a specific fate." [GOC:go_curators] synonym: "activation of cell fate specification" NARROW [] synonym: "stimulation of cell fate specification" NARROW [] synonym: "up regulation of cell fate specification" EXACT [] synonym: "up-regulation of cell fate specification" EXACT [] synonym: "upregulation of cell fate specification" EXACT [] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0045597 ! positive regulation of cell differentiation relationship: positively_regulates GO:0001708 ! cell fate specification [Term] id: GO:0042661 name: regulation of mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:2000027 ! regulation of organ morphogenesis is_a: GO:2000380 ! regulation of mesoderm development relationship: regulates GO:0007501 ! mesodermal cell fate specification [Term] id: GO:0042662 name: negative regulation of mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators] synonym: "down regulation of mesodermal cell fate specification" EXACT [] synonym: "down-regulation of mesodermal cell fate specification" EXACT [] synonym: "downregulation of mesodermal cell fate specification" EXACT [] synonym: "inhibition of mesodermal cell fate specification" NARROW [] synonym: "suppression of mesodermal cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042661 ! regulation of mesodermal cell fate specification relationship: negatively_regulates GO:0007501 ! mesodermal cell fate specification [Term] id: GO:0042663 name: regulation of endodermal cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into an endoderm cell." [GOC:go_curators] synonym: "regulation of endoderm cell fate specification" EXACT [] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0042659 ! regulation of cell fate specification relationship: regulates GO:0001714 ! endodermal cell fate specification [Term] id: GO:0042664 name: negative regulation of endodermal cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into an endoderm cell." [GOC:go_curators] synonym: "down regulation of endodermal cell fate specification" EXACT [] synonym: "down-regulation of endodermal cell fate specification" EXACT [] synonym: "downregulation of endodermal cell fate specification" EXACT [] synonym: "inhibition of endodermal cell fate specification" NARROW [] synonym: "negative regulation of endoderm cell fate specification" EXACT [] synonym: "suppression of endoderm cell fate" EXACT [] synonym: "suppression of endodermal cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042663 ! regulation of endodermal cell fate specification relationship: negatively_regulates GO:0001714 ! endodermal cell fate specification [Term] id: GO:0042665 name: regulation of ectodermal cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into an ectoderm cell." [GOC:go_curators] synonym: "regulation of ectoderm cell fate specification" EXACT [] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:2000383 ! regulation of ectoderm development relationship: regulates GO:0001715 ! ectodermal cell fate specification [Term] id: GO:0042666 name: negative regulation of ectodermal cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell." [GOC:go_curators] synonym: "down regulation of ectodermal cell fate specification" EXACT [] synonym: "down-regulation of ectodermal cell fate specification" EXACT [] synonym: "downregulation of ectodermal cell fate specification" EXACT [] synonym: "inhibition of ectodermal cell fate specification" NARROW [] synonym: "negative regulation of ectoderm cell fate specification" EXACT [] synonym: "suppression of ectoderm cell fate" EXACT [] synonym: "suppression of ectodermal cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042665 ! regulation of ectodermal cell fate specification relationship: negatively_regulates GO:0001715 ! ectodermal cell fate specification [Term] id: GO:0042667 name: auditory receptor cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "auditory hair cell fate specification" EXACT [] is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0009912 ! auditory receptor cell fate commitment [Term] id: GO:0042668 name: auditory receptor cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] synonym: "auditory hair cell fate determination" EXACT [] is_a: GO:0048664 ! neuron fate determination relationship: part_of GO:0009912 ! auditory receptor cell fate commitment [Term] id: GO:0042669 name: regulation of auditory receptor cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into an auditory hair cell." [GOC:go_curators] synonym: "regulation of auditory hair cell fate specification" EXACT [] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0045607 ! regulation of auditory receptor cell differentiation relationship: regulates GO:0042667 ! auditory receptor cell fate specification [Term] id: GO:0042670 name: retinal cone cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation [Term] id: GO:0042671 name: retinal cone cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0043703 ! photoreceptor cell fate determination relationship: part_of GO:0046551 ! retinal cone cell fate commitment [Term] id: GO:0042672 name: retinal cone cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] is_a: GO:0043704 ! photoreceptor cell fate specification relationship: part_of GO:0046551 ! retinal cone cell fate commitment [Term] id: GO:0042673 name: regulation of retinal cone cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0060222 ! regulation of retinal cone cell fate commitment relationship: regulates GO:0042672 ! retinal cone cell fate specification [Term] id: GO:0042675 name: compound eye cone cell differentiation namespace: biological_process alt_id: GO:0042674 def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0042676 name: compound eye cone cell fate commitment namespace: biological_process alt_id: GO:0007466 def: "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0042675 ! compound eye cone cell differentiation [Term] id: GO:0042679 name: compound eye cone cell fate specification namespace: biological_process alt_id: GO:0042678 def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0042676 ! compound eye cone cell fate commitment [Term] id: GO:0042680 name: compound eye cone cell fate determination namespace: biological_process alt_id: GO:0042677 def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0042676 ! compound eye cone cell fate commitment [Term] id: GO:0042682 name: regulation of compound eye cone cell fate specification namespace: biological_process alt_id: GO:0042681 def: "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0042679 ! compound eye cone cell fate specification [Term] id: GO:0042683 name: negative regulation of compound eye cone cell fate specification namespace: biological_process alt_id: GO:0010000 def: "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu] synonym: "down regulation of cone cell fate specification" BROAD [] synonym: "down-regulation of cone cell fate specification" BROAD [] synonym: "downregulation of cone cell fate specification" BROAD [] synonym: "inhibition of cone cell fate specification" BROAD [] synonym: "suppression of cone cell fate" BROAD [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042682 ! regulation of compound eye cone cell fate specification relationship: negatively_regulates GO:0042679 ! compound eye cone cell fate specification [Term] id: GO:0042684 name: cardioblast cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0010002 ! cardioblast differentiation [Term] id: GO:0042685 name: cardioblast cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0060912 ! cardiac cell fate specification relationship: part_of GO:0042684 ! cardioblast cell fate commitment [Term] id: GO:0042686 name: regulation of cardioblast cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:2000043 ! regulation of cardiac cell fate specification relationship: regulates GO:0042685 ! cardioblast cell fate specification [Term] id: GO:0042688 name: crystal cell differentiation namespace: biological_process def: "The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] is_a: GO:0042386 ! hemocyte differentiation [Term] id: GO:0042689 name: regulation of crystal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] is_a: GO:0045610 ! regulation of hemocyte differentiation relationship: regulates GO:0042688 ! crystal cell differentiation [Term] id: GO:0042690 name: negative regulation of crystal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] synonym: "down regulation of crystal cell differentiation" EXACT [] synonym: "down-regulation of crystal cell differentiation" EXACT [] synonym: "downregulation of crystal cell differentiation" EXACT [] synonym: "inhibition of crystal cell differentiation" NARROW [] is_a: GO:0042689 ! regulation of crystal cell differentiation is_a: GO:0045611 ! negative regulation of hemocyte differentiation relationship: negatively_regulates GO:0042688 ! crystal cell differentiation [Term] id: GO:0042691 name: positive regulation of crystal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] synonym: "activation of crystal cell differentiation" NARROW [] synonym: "stimulation of crystal cell differentiation" NARROW [] synonym: "up regulation of crystal cell differentiation" EXACT [] synonym: "up-regulation of crystal cell differentiation" EXACT [] synonym: "upregulation of crystal cell differentiation" EXACT [] is_a: GO:0042689 ! regulation of crystal cell differentiation is_a: GO:0045612 ! positive regulation of hemocyte differentiation relationship: positively_regulates GO:0042688 ! crystal cell differentiation [Term] id: GO:0042692 name: muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] xref: Reactome:1253632 "Myogenesis" xref: Reactome:1280564 "Myogenesis" xref: Reactome:1299396 "Myogenesis" xref: Reactome:1327149 "Myogenesis" xref: Reactome:1353244 "Myogenesis" xref: Reactome:1373417 "Myogenesis" xref: Reactome:1393442 "Myogenesis" xref: Reactome:1417944 "Myogenesis" xref: Reactome:1451029 "Myogenesis" xref: Reactome:1471405 "Myogenesis" xref: Reactome:525793 "Myogenesis" is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0061061 ! muscle structure development [Term] id: GO:0042693 name: muscle cell fate commitment namespace: biological_process def: "The process in which the cellular identity of muscle cells is acquired and determined." [CL:0000187, GOC:go_curators] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0042692 ! muscle cell differentiation [Term] id: GO:0042694 name: muscle cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0042693 ! muscle cell fate commitment [Term] id: GO:0042695 name: thelarche namespace: biological_process def: "The beginning of development of the breasts in the female." [GOC:curators, PMID:19117864] xref: Wikipedia:Thelarche is_a: GO:0046543 ! development of secondary female sexual characteristics relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0042696 name: menarche namespace: biological_process def: "The beginning of the menstrual cycle; the first menstrual cycle in an individual." [GOC:curators, PMID:16311040] xref: Wikipedia:Menarche is_a: GO:0022601 ! menstrual cycle phase is_a: GO:0046543 ! development of secondary female sexual characteristics [Term] id: GO:0042697 name: menopause namespace: biological_process def: "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50." [GOC:curators, PMID:18495681] xref: Wikipedia:Menopause is_a: GO:0022601 ! menstrual cycle phase is_a: GO:0046543 ! development of secondary female sexual characteristics relationship: part_of GO:0010259 ! multicellular organismal aging [Term] id: GO:0042698 name: ovulation cycle namespace: biological_process def: "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "estrous cycle" RELATED [] synonym: "menstrual cycle" RELATED [] is_a: GO:0048511 ! rhythmic process is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0042699 name: follicle-stimulating hormone signaling pathway namespace: biological_process def: "The series of molecular signals mediated by follicle-stimulating hormone." [GOC:dph] synonym: "follicle stimulating hormone signaling pathway" EXACT [] synonym: "follicle stimulating hormone signalling pathway" EXACT [] synonym: "follicle-stimulating hormone signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0042700 name: luteinizing hormone signaling pathway namespace: biological_process def: "The series of molecular signals mediated by luteinizing hormone." [GOC:dph] synonym: "luteinizing hormone signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0042701 name: progesterone secretion namespace: biological_process def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172] is_a: GO:0006869 ! lipid transport is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0060986 ! endocrine hormone secretion relationship: part_of GO:0001553 ! luteinization [Term] id: GO:0042702 name: uterine wall growth namespace: biological_process def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001553 ! luteinization [Term] id: GO:0042703 name: menstruation namespace: biological_process def: "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." [GOC:curators, PMID:8693059] xref: Wikipedia:Menstruation is_a: GO:0022601 ! menstrual cycle phase [Term] id: GO:0042704 name: uterine wall breakdown namespace: biological_process def: "The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels." [GOC:dph] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0042703 ! menstruation [Term] id: GO:0042705 name: ocellus photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0042706 name: eye photoreceptor cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0046552 ! photoreceptor cell fate commitment relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation [Term] id: GO:0042707 name: ocellus photoreceptor cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0046552 ! photoreceptor cell fate commitment relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation [Term] id: GO:0042708 name: elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of elastin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0042709 name: succinate-CoA ligase complex namespace: cellular_component def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [EC:6.2.1.4, EC:6.2.1.5, GOC:jl] subset: gosubset_prok is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex [Term] id: GO:0042710 name: biofilm formation namespace: biological_process def: "A process in which microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [PMID:11932229] subset: goslim_candida subset: goslim_pir subset: gosubset_prok is_a: GO:0051704 ! multi-organism process [Term] id: GO:0042711 name: maternal behavior namespace: biological_process def: "Female behaviors associated with the care and rearing of offspring." [GOC:curators] synonym: "maternal behaviour" EXACT [] is_a: GO:0060746 ! parental behavior [Term] id: GO:0042712 name: paternal behavior namespace: biological_process def: "Male behaviors associated with the care and rearing offspring." [GOC:go_curators] synonym: "paternal behaviour" EXACT [] is_a: GO:0060746 ! parental behavior [Term] id: GO:0042713 name: sperm ejaculation namespace: biological_process def: "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007320 ! insemination [Term] id: GO:0042714 name: dosage compensation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493] is_a: GO:0034622 ! cellular macromolecular complex assembly relationship: part_of GO:0007549 ! dosage compensation [Term] id: GO:0042715 name: dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361, PMID:12672493] synonym: "dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome" RELATED [GOC:dph, GOC:tb] is_a: GO:0042714 ! dosage compensation complex assembly is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0042464 ! dosage compensation, by hypoactivation of X chromosome [Term] id: GO:0042716 name: plasma membrane-derived chromatophore namespace: cellular_component def: "A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria." [GOC:jl, ISBN:0395825172, PMID:11867431] comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin. subset: gosubset_prok synonym: "chromatophore vesicle" RELATED [] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0042717 name: plasma membrane-derived chromatophore membrane namespace: cellular_component def: "The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles." [GOC:jl, GOC:mah, ISBN:0395825172, PMID:11867431] subset: gosubset_prok is_a: GO:0034357 ! photosynthetic membrane is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0042718 name: yolk granule namespace: cellular_component def: "Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, http://148.216.10.83/cellbio/eggs.htm, PMID:18046696] is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0060417 ! yolk [Term] id: GO:0042719 name: mitochondrial intermembrane space protein transporter complex namespace: cellular_component def: "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629] synonym: "Tim9-Tim10 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005758 ! mitochondrial intermembrane space [Term] id: GO:0042720 name: mitochondrial inner membrane peptidase complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769] synonym: "IMP" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0042721 name: mitochondrial inner membrane protein insertion complex namespace: cellular_component def: "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane." [PMID:12191765] synonym: "Tim22 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0042722 name: alpha-beta T cell activation by superantigen namespace: biological_process def: "The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region." [GOC:jl] synonym: "alpha-beta T lymphocyte activation by superantigen" EXACT [] synonym: "alpha-beta T-cell activation by superantigen" EXACT [] synonym: "alpha-beta T-lymphocyte activation by superantigen" EXACT [] is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0042723 name: thiamine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it." [CHEBI:26948, GOC:jl] subset: gosubset_prok synonym: "thiamin and derivative metabolic process" EXACT [GOC:curators] synonym: "thiamin and derivative metabolism" EXACT [] synonym: "thiamin-containing compound metabolic process" EXACT [GOC:curators] synonym: "thiamine and derivative metabolic process" EXACT [] synonym: "thiamine and derivative metabolism" EXACT [] synonym: "thiamine-containing compound metabolism" EXACT [GOC:curators] synonym: "vitamin B1 and derivative metabolic process" EXACT [] synonym: "vitamin B1 and derivative metabolism" EXACT [] xref: Reactome:1253506 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1280445 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1299279 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1327023 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1353117 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1373306 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1393319 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1417817 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1450915 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1471295 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1483268 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1496937 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1514324 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1521196 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1526942 "Vitamin B1 (thiamin) metabolism" xref: Reactome:1536092 "Vitamin B1 (thiamin) metabolism" xref: Reactome:196819 "Vitamin B1 (thiamin) metabolism" is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0042724 name: thiamine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds." [CHEBI:26948, GOC:jl] subset: gosubset_prok synonym: "thiamin and derivative biosynthesis" EXACT [] synonym: "thiamin and derivative biosynthetic process" EXACT [GOC:curators] synonym: "thiamin-containing compound biosynthetic process" EXACT [GOC:curators] synonym: "thiamine and derivative biosynthesis" EXACT [] synonym: "thiamine and derivative biosynthetic process" EXACT [] synonym: "thiamine-containing compound anabolism" EXACT [GOC:curators] synonym: "thiamine-containing compound biosynthesis" EXACT [GOC:curators] synonym: "thiamine-containing compound formation" EXACT [GOC:curators] synonym: "thiamine-containing compound synthesis" EXACT [GOC:curators] synonym: "vitamin B1 and derivative biosynthesis" EXACT [] synonym: "vitamin B1 and derivative biosynthetic process" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042723 ! thiamine-containing compound metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0042725 name: thiamine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it." [CHEBI:26948, GOC:jl] subset: gosubset_prok synonym: "thiamin and derivative catabolic process" EXACT [GOC:curators] synonym: "thiamin and derivative catabolism" EXACT [] synonym: "thiamin-containing compound catabolic process" EXACT [GOC:curators] synonym: "thiamine and derivative catabolic process" EXACT [] synonym: "thiamine and derivative catabolism" EXACT [] synonym: "thiamine-containing compound breakdown" EXACT [GOC:curators] synonym: "thiamine-containing compound catabolism" EXACT [GOC:curators] synonym: "thiamine-containing compound degradation" EXACT [GOC:curators] synonym: "vitamin B1 and derivative catabolic process" EXACT [] synonym: "vitamin B1 and derivative catabolism" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042723 ! thiamine-containing compound metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0042726 name: flavin-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [CHEBI:30527, GOC:jl, GOC:mah] subset: gosubset_prok synonym: "flavin-containing compound metabolism" EXACT [GOc:curators] synonym: "riboflavin and derivative metabolic process" RELATED [GOC:curators] synonym: "riboflavin and derivative metabolism" RELATED [GOC:curators] synonym: "vitamin B2 and derivative metabolic process" RELATED [GOC:curators] synonym: "vitamin B2 and derivative metabolism" RELATED [GOC:curators] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0042727 name: flavin-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [CHEBI:30527, GOC:jl, GOC:mah] subset: gosubset_prok synonym: "flavin-containing compound anabolism" EXACT [GOC:curators] synonym: "flavin-containing compound biosynthesis" EXACT [GOC:curators] synonym: "flavin-containing compound formation" EXACT [GOC:curators] synonym: "flavin-containing compound synthesis" EXACT [GOC:curators] synonym: "riboflavin and derivative biosynthesis" RELATED [GOC:curators] synonym: "riboflavin and derivative biosynthetic process" RELATED [GOC:curators] synonym: "vitamin B2 and derivative biosynthesis" RELATED [GOC:curators] synonym: "vitamin B2 and derivative biosynthetic process" RELATED [GOC:curators] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042726 ! flavin-containing compound metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0042728 name: flavin-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [CHEBI:30527, GOC:jl, GOC:mah] subset: gosubset_prok synonym: "flavin-containing compound catabolic process breakdown" EXACT [GOC:curators] synonym: "flavin-containing compound catabolic process degradation" EXACT [GOC:curators] synonym: "flavin-containing compound catabolism" EXACT [GOC:curators] synonym: "riboflavin and derivative catabolic process" RELATED [GOc:curators] synonym: "riboflavin and derivative catabolism" RELATED [GOC:curators] synonym: "vitamin B2 and derivative catabolic process" RELATED [GOC:curators] synonym: "vitamin B2 and derivative catabolism" RELATED [GOC:curators] is_a: GO:0042726 ! flavin-containing compound metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0042729 name: DASH complex namespace: cellular_component alt_id: GO:0043925 alt_id: GO:0043926 def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability." [GOC:jl, PMID:11782438, PMID:11799062] comment: Note that this complex is conserved in fungi but has not been observed in metazoans. synonym: "condensed nuclear chromosome kinetochore-associated DASH complex" EXACT [] synonym: "Dam1 complex" EXACT [] synonym: "DDD complex" EXACT [] synonym: "Duo1p-Dam1p-Dad1p complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0042730 name: fibrinolysis namespace: biological_process def: "An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots." [GOC:jl, PMID:15842654] xref: Reactome:1253294 "Dissolution of Fibrin Clot" xref: Reactome:1280231 "Dissolution of Fibrin Clot" xref: Reactome:1299091 "Dissolution of Fibrin Clot" xref: Reactome:1326807 "Dissolution of Fibrin Clot" xref: Reactome:1352908 "Dissolution of Fibrin Clot" xref: Reactome:1373114 "Dissolution of Fibrin Clot" xref: Reactome:1393130 "Dissolution of Fibrin Clot" xref: Reactome:1417618 "Dissolution of Fibrin Clot" xref: Reactome:1450712 "Dissolution of Fibrin Clot" xref: Reactome:1483162 "Dissolution of Fibrin Clot" xref: Reactome:75205 "Dissolution of Fibrin Clot" xref: Wikipedia:Fibrinolysis is_a: GO:0030195 ! negative regulation of blood coagulation [Term] id: GO:0042731 name: PH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton." [GOC:jl, Pfam:PF00169] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0042732 name: D-xylose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-xylose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0042733 name: embryonic digit morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe." [GOC:bf, GOC:jl, UBERON:0002544] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0030326 ! embryonic limb morphogenesis [Term] id: GO:0042734 name: presynaptic membrane namespace: cellular_component def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194] is_a: GO:0097060 ! synaptic membrane [Term] id: GO:0042735 name: protein body namespace: cellular_component def: "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047] is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0042736 name: NADH kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH." [EC:2.7.1.86, RHEA:12263] synonym: "ATP:NADH 2'-phosphotransferase activity" EXACT [EC:2.7.1.86] synonym: "DPNH kinase activity" EXACT [EC:2.7.1.86] synonym: "reduced diphosphopyridine nucleotide kinase activity" EXACT [EC:2.7.1.86] synonym: "reduced nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.86] xref: EC:2.7.1.86 xref: KEGG:R00105 xref: MetaCyc:NADH-KINASE-RXN xref: RHEA:12263 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0042737 name: drug catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease." [GOC:go_curators] subset: gosubset_prok synonym: "drug breakdown" EXACT [] synonym: "drug catabolism" EXACT [] synonym: "drug degradation" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0042738 name: exogenous drug catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism." [GOC:jl] subset: gosubset_prok synonym: "exogenous drug breakdown" EXACT [] synonym: "exogenous drug catabolism" EXACT [] synonym: "exogenous drug degradation" EXACT [] is_a: GO:0042737 ! drug catabolic process relationship: part_of GO:0042493 ! response to drug [Term] id: GO:0042739 name: endogenous drug catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism." [GOC:jl] subset: gosubset_prok synonym: "endogenous drug breakdown" EXACT [] synonym: "endogenous drug catabolism" EXACT [] synonym: "endogenous drug degradation" EXACT [] is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0042740 name: exogenous antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism." [GOC:jl] subset: gosubset_prok synonym: "exogenous antibiotic breakdown" EXACT [] synonym: "exogenous antibiotic catabolism" EXACT [] synonym: "exogenous antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042738 ! exogenous drug catabolic process relationship: part_of GO:0046677 ! response to antibiotic [Term] id: GO:0042741 name: endogenous antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism." [GOC:jl] subset: gosubset_prok synonym: "endogenous antibiotic breakdown" EXACT [] synonym: "endogenous antibiotic catabolism" EXACT [] synonym: "endogenous antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042739 ! endogenous drug catabolic process [Term] id: GO:0042742 name: defense response to bacterium namespace: biological_process alt_id: GO:0042830 def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] subset: gosubset_prok synonym: "antibacterial peptide activity" RELATED [] synonym: "defence response to bacteria" EXACT [] synonym: "defence response to bacterium" EXACT [] synonym: "defense response to bacteria" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0009617 ! response to bacterium [Term] id: GO:0042743 name: hydrogen peroxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, http://biotech.icmb.utexas.edu/] subset: gosubset_prok synonym: "H2O2 metabolic process" EXACT [GOC:mah] synonym: "hydrogen peroxide metabolism" EXACT [] is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:0042744 name: hydrogen peroxide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl] subset: gosubset_prok synonym: "detoxification of H2O2" RELATED [GOC:vw] synonym: "detoxification of hydrogen peroxide" RELATED [GOC:vw] synonym: "H2O2 catabolic process" EXACT [GOC:mah] synonym: "H2O2 scavenging" RELATED [GOC:vw] synonym: "hydrogen peroxide breakdown" EXACT [] synonym: "hydrogen peroxide catabolism" EXACT [] synonym: "hydrogen peroxide degradation" EXACT [] synonym: "hydrogen peroxide removal" RELATED [] synonym: "hydrogen peroxide scavenging" RELATED [GOC:vw] is_a: GO:0042743 ! hydrogen peroxide metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0070301 ! cellular response to hydrogen peroxide [Term] id: GO:0042745 name: circadian sleep/wake cycle namespace: biological_process def: "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com] is_a: GO:0048512 ! circadian behavior [Term] id: GO:0042746 name: circadian sleep/wake cycle, wakefulness namespace: biological_process def: "The part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:jl, PMID:12575468] is_a: GO:0022410 ! circadian sleep/wake cycle process [Term] id: GO:0042747 name: circadian sleep/wake cycle, REM sleep namespace: biological_process def: "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [GOC:jl, ISBN:0395825172] is_a: GO:0022410 ! circadian sleep/wake cycle process relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0042748 name: circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, http://www.sleepquest.com] is_a: GO:0022410 ! circadian sleep/wake cycle process relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0042749 name: regulation of circadian sleep/wake cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl] is_a: GO:0022410 ! circadian sleep/wake cycle process is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0050795 ! regulation of behavior is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0042745 ! circadian sleep/wake cycle [Term] id: GO:0042750 name: hibernation namespace: biological_process def: "Any process in which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs." [GOC:jl, PMID:1945046] xref: Wikipedia:Hibernation is_a: GO:0022611 ! dormancy process is_a: GO:0030431 ! sleep [Term] id: GO:0042751 name: estivation namespace: biological_process def: "Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season." [GOC:jl, http://www.wikipedia.org/Estivation, PMID:12443930] xref: Wikipedia:Estivation is_a: GO:0022611 ! dormancy process is_a: GO:0030431 ! sleep [Term] id: GO:0042752 name: regulation of circadian rhythm namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0007623 ! circadian rhythm [Term] id: GO:0042753 name: positive regulation of circadian rhythm namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] synonym: "activation of circadian rhythm" NARROW [] synonym: "stimulation of circadian rhythm" NARROW [] synonym: "up regulation of circadian rhythm" EXACT [] synonym: "up-regulation of circadian rhythm" EXACT [] synonym: "upregulation of circadian rhythm" EXACT [] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0007623 ! circadian rhythm [Term] id: GO:0042754 name: negative regulation of circadian rhythm namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] synonym: "down regulation of circadian rhythm" EXACT [] synonym: "down-regulation of circadian rhythm" EXACT [] synonym: "downregulation of circadian rhythm" EXACT [] synonym: "inhibition of circadian rhythm" NARROW [] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0007623 ! circadian rhythm [Term] id: GO:0042755 name: eating behavior namespace: biological_process def: "The specific actions or reactions of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, ISBN:01928006X] synonym: "eating behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior [Term] id: GO:0042756 name: drinking behavior namespace: biological_process def: "The specific actions or reactions of an organism relating to the intake of liquids, especially water." [GOC:curators] synonym: "drinking behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior [Term] id: GO:0042757 name: giant axon namespace: cellular_component def: "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, PMID:9705477] is_a: GO:0030424 ! axon [Term] id: GO:0042758 name: long-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:go_curators] subset: gosubset_prok synonym: "long-chain fatty acid breakdown" EXACT [] synonym: "long-chain fatty acid catabolism" EXACT [] synonym: "long-chain fatty acid degradation" EXACT [] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0009062 ! fatty acid catabolic process [Term] id: GO:0042759 name: long-chain fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:go_curators] subset: gosubset_prok synonym: "long-chain fatty acid anabolism" EXACT [] synonym: "long-chain fatty acid biosynthesis" EXACT [] synonym: "long-chain fatty acid formation" EXACT [] synonym: "long-chain fatty acid synthesis" EXACT [] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0042760 name: very long-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of C18 or greater." [GOC:go_curators] subset: gosubset_prok synonym: "very-long-chain fatty acid breakdown" EXACT [] synonym: "very-long-chain fatty acid catabolic process" EXACT [] synonym: "very-long-chain fatty acid catabolism" EXACT [] synonym: "very-long-chain fatty acid degradation" EXACT [] is_a: GO:0000038 ! very long-chain fatty acid metabolic process is_a: GO:0009062 ! fatty acid catabolic process [Term] id: GO:0042761 name: very long-chain fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of C18 or greater." [GOC:go_curators] subset: gosubset_prok synonym: "very-long-chain fatty acid anabolism" EXACT [] synonym: "very-long-chain fatty acid biosynthesis" EXACT [] synonym: "very-long-chain fatty acid biosynthetic process" EXACT [] synonym: "very-long-chain fatty acid formation" EXACT [] synonym: "very-long-chain fatty acid synthesis" EXACT [] xref: MetaCyc:PWY-5080 is_a: GO:0000038 ! very long-chain fatty acid metabolic process is_a: GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0042762 name: regulation of sulfur metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of sulfur metabolism" EXACT [] synonym: "regulation of sulphur metabolic process" EXACT [] synonym: "regulation of sulphur metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0042763 name: intracellular immature spore namespace: cellular_component def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172] subset: gosubset_prok synonym: "forespore" RELATED [] is_a: GO:0044464 ! cell part [Term] id: GO:0042764 name: ascospore-type prospore namespace: cellular_component def: "An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascopore-forming fungi." [GOC:go_curators] is_a: GO:0042763 ! intracellular immature spore [Term] id: GO:0042765 name: GPI-anchor transamidase complex namespace: cellular_component def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054] comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity. synonym: "GPIT complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0030176 ! integral to endoplasmic reticulum membrane [Term] id: GO:0042766 name: nucleosome mobilization namespace: biological_process def: "The movement of nucleosomes along a DNA fragment." [PMID:12006495] is_a: GO:0006338 ! chromatin remodeling is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0042767 name: ecdysteroid 22-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427] comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone. is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0042768 name: ecdysteroid 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427] comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone. is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0042769 name: DNA damage response, detection of DNA damage namespace: biological_process def: "The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal." [GOC:go_curators] synonym: "detection of DNA damage during DNA damage response" EXACT [] synonym: "DNA damage response, perception of DNA damage" RELATED [] is_a: GO:0006974 ! response to DNA damage stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0042770 name: signal transduction in response to DNA damage namespace: biological_process def: "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] synonym: "DNA damage response, signal transduction" EXACT [GOC:curators] synonym: "response to DNA damage stimulus by intracellular signaling cascade" EXACT [GOC:dph, GOC:tb] is_a: GO:0006974 ! response to DNA damage stimulus is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0042771 name: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death)." [GOC:go_curators] is_a: GO:0008630 ! DNA damage response, signal transduction resulting in induction of apoptosis is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator is_a: GO:0072332 ! signal transduction by p53 class mediator resulting in induction of apoptosis [Term] id: GO:0042772 name: DNA damage response, signal transduction resulting in transcription namespace: biological_process def: "A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription." [GOC:go_curators] is_a: GO:0042770 ! signal transduction in response to DNA damage [Term] id: GO:0042773 name: ATP synthesis coupled electron transport namespace: biological_process def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] subset: gosubset_prok is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0006119 ! oxidative phosphorylation [Term] id: GO:0042774 name: plasma membrane ATP synthesis coupled electron transport namespace: biological_process def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane." [GOC:mtg_sensu, ISBN:0716731363] subset: gosubset_prok is_a: GO:0042773 ! ATP synthesis coupled electron transport [Term] id: GO:0042775 name: mitochondrial ATP synthesis coupled electron transport namespace: biological_process def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363] synonym: "mitochondrial electron transport" BROAD [] synonym: "organelle ATP synthesis coupled electron transport" BROAD [] is_a: GO:0042773 ! ATP synthesis coupled electron transport [Term] id: GO:0042776 name: mitochondrial ATP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363] synonym: "mitochondrial proton transport" BROAD [] xref: Reactome:1233687 "Enzyme-bound ATP is released" xref: Reactome:1253343 "Formation of ATP by chemiosmotic coupling" xref: Reactome:1261393 "Enzyme-bound ATP is released" xref: Reactome:1280281 "Formation of ATP by chemiosmotic coupling" xref: Reactome:1286276 "Enzyme-bound ATP is released" xref: Reactome:1299134 "Formation of ATP by chemiosmotic coupling" xref: Reactome:1307338 "Enzyme-bound ATP is released" xref: Reactome:1326859 "Formation of ATP by chemiosmotic coupling" xref: Reactome:1334723 "Enzyme-bound ATP is released" xref: Reactome:1352951 "Formation of ATP by chemiosmotic coupling" xref: Reactome:1359064 "Enzyme-bound ATP is released" xref: Reactome:1373154 "Formation of ATP by chemiosmotic coupling" xref: Reactome:1379972 "Enzyme-bound ATP is released" xref: Reactome:1393171 "Formation of ATP by chemiosmotic coupling" xref: Reactome:1428299 "Enzyme-bound ATP is released" xref: Reactome:1450759 "Formation of ATP by chemiosmotic coupling" xref: Reactome:163210 "Formation of ATP by chemiosmotic coupling" xref: Reactome:164834 "Enzyme-bound ATP is released" is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015986 ! ATP synthesis coupled proton transport [Term] id: GO:0042777 name: plasma membrane ATP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363] subset: gosubset_prok synonym: "ATP synthesis coupled proton transport" BROAD [] is_a: GO:0015986 ! ATP synthesis coupled proton transport [Term] id: GO:0042778 name: tRNA end turnover namespace: biological_process def: "The process in which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006399 ! tRNA metabolic process [Term] id: GO:0042779 name: tRNA 3'-trailer cleavage namespace: biological_process def: "Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators] subset: gosubset_prok synonym: "removal of tRNA 3'-trailer sequence" EXACT [] synonym: "tRNA 3'-end cleavage" EXACT [] is_a: GO:0042780 ! tRNA 3'-end processing is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0042780 name: tRNA 3'-end processing namespace: biological_process def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators] subset: gosubset_prok synonym: "tRNA 3' processing" EXACT [] is_a: GO:0008033 ! tRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0042781 name: 3'-tRNA processing endoribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [EC:3.1.26.11] subset: gosubset_prok synonym: "3 tRNase activity" EXACT [EC:3.1.26.11] synonym: "3' tRNA processing endoribonuclease activity" EXACT [] synonym: "3' tRNase activity" BROAD [] synonym: "ribonuclease Z activity" BROAD [] synonym: "RNase Z activity" BROAD [] synonym: "tRNA 3 endonuclease activity" EXACT [EC:3.1.26.11] synonym: "tRNA 3' endonuclease activity" EXACT [] synonym: "tRNase Z" RELATED [EC:3.1.26.11] synonym: "tRNAse Z" RELATED [EC:3.1.26.11] xref: MetaCyc:3.1.26.11-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0042782 name: passive evasion of host immune response namespace: biological_process def: "Any mechanism of immune avoidance that does not directly interfere with the host immune system; for example, some viruses enter a state of latency where their protein production is drastically downregulated, meaning that they are not detected by the host immune system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615] subset: gosubset_prok synonym: "passive immune evasion" BROAD [] is_a: GO:0020012 ! evasion or tolerance of host immune response is_a: GO:0051809 ! passive evasion of immune response of other organism involved in symbiotic interaction [Term] id: GO:0042783 name: active evasion of host immune response namespace: biological_process def: "Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615] subset: gosubset_prok synonym: "active immune evasion" BROAD [] is_a: GO:0020012 ! evasion or tolerance of host immune response is_a: GO:0051810 ! active evasion of immune response of other organism involved in symbiotic interaction [Term] id: GO:0042784 name: active evasion of host immune response via regulation of host complement system namespace: biological_process def: "Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] synonym: "active immune evasion via modulation of host complement system" EXACT [] synonym: "active immune evasion via regulation of host complement system" EXACT [] is_a: GO:0042783 ! active evasion of host immune response is_a: GO:0051811 ! active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction [Term] id: GO:0042785 name: active evasion of host immune response via regulation of host cytokine network namespace: biological_process def: "Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] synonym: "active immune evasion via modulation of host cytokine network" EXACT [] synonym: "active immune evasion via regulation of host cytokine network" EXACT [] is_a: GO:0042783 ! active evasion of host immune response is_a: GO:0051812 ! active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction [Term] id: GO:0042786 name: active evasion of host immune response via regulation of host antigen processing and presentation namespace: biological_process def: "Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615] synonym: "active evasion of host immune response via regulation of host antigen processing and presentation pathway" EXACT [] synonym: "active immune evasion via modulation of antigen processing and presentation" EXACT [] synonym: "active immune evasion via modulation of antigen processing/presentation" EXACT [] synonym: "active immune evasion via regulation of antigen processing and presentation" EXACT [] is_a: GO:0042783 ! active evasion of host immune response [Term] id: GO:0042787 name: protein ubiquitination involved in ubiquitin-dependent protein catabolic process namespace: biological_process alt_id: GO:0043432 def: "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW [] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [] synonym: "protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [] synonym: "protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [] synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [] synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [] synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [] synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [] xref: Reactome:1235326 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1235427 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1235465 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1235499 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1235504 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:1262670 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1262757 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1262792 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1262823 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1262828 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:1308945 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1309025 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1309060 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1309090 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1309095 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:1336008 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1336099 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1336134 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1336165 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1336170 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:1360114 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1360146 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1360170 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1360203 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1360206 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:1380839 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1380942 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1380965 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1381004 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1381009 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:1401948 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1402045 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1402080 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1402111 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1402116 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:1429928 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1430065 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1430111 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1430145 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1430148 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:1458688 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1458798 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1458823 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1458891 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1458894 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:1489813 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1489977 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:1489990 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:1489992 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1504877 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:1505150 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:1518056 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:174057 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" is_a: GO:0016567 ! protein ubiquitination relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process [Term] id: GO:0042788 name: polysomal ribosome namespace: cellular_component def: "A ribosome bound to mRNA that forms part of a polysome." [GOC:jl] synonym: "active ribosome" BROAD [] is_a: GO:0005840 ! ribosome relationship: part_of GO:0005844 ! polysome [Term] id: GO:0042789 name: mRNA transcription from RNA polymerase II promoter namespace: biological_process def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:jl, ISBN:0321000382] synonym: "mRNA transcription from Pol II promoter" EXACT [] is_a: GO:0006366 ! transcription from RNA polymerase II promoter is_a: GO:0009299 ! mRNA transcription [Term] id: GO:0042790 name: transcription of nuclear rRNA large RNA polymerase I transcript namespace: biological_process def: "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template." [GOC:jl, ISBN:0321000382] synonym: "transcription of nuclear rRNA large Pol I transcript" EXACT [] is_a: GO:0006360 ! transcription from RNA polymerase I promoter is_a: GO:0009303 ! rRNA transcription [Term] id: GO:0042791 name: 5S class rRNA transcription from RNA polymerase III type 1 promoter namespace: biological_process def: "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter." [GOC:jl, GOC:txnOH, ISBN:0321000382, PMID:12381659] subset: gosubset_prok synonym: "5S rRNA transcription" EXACT [] is_a: GO:0006383 ! transcription from RNA polymerase III promoter is_a: GO:0009303 ! rRNA transcription [Term] id: GO:0042792 name: rRNA transcription from mitochondrial promoter namespace: biological_process def: "The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template." [GOC:jl, ISBN:0321000382] is_a: GO:0006390 ! transcription from mitochondrial promoter is_a: GO:0009303 ! rRNA transcription [Term] id: GO:0042793 name: transcription from plastid promoter namespace: biological_process def: "The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382] synonym: "plastid transcription" EXACT [] is_a: GO:0006351 ! transcription, DNA-dependent is_a: GO:0009657 ! plastid organization [Term] id: GO:0042794 name: rRNA transcription from plastid promoter namespace: biological_process def: "The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382] is_a: GO:0009303 ! rRNA transcription is_a: GO:0042793 ! transcription from plastid promoter [Term] id: GO:0042795 name: snRNA transcription from RNA polymerase II promoter namespace: biological_process def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382] synonym: "snRNA transcription from Pol II promoter" EXACT [] is_a: GO:0006366 ! transcription from RNA polymerase II promoter is_a: GO:0009301 ! snRNA transcription [Term] id: GO:0042796 name: snRNA transcription from RNA polymerase III promoter namespace: biological_process def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] synonym: "snRNA transcription from Pol III promoter" EXACT [] is_a: GO:0006383 ! transcription from RNA polymerase III promoter is_a: GO:0009301 ! snRNA transcription [Term] id: GO:0042797 name: tRNA transcription from RNA polymerase III promoter namespace: biological_process def: "The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] synonym: "tRNA transcription from Pol III promoter" EXACT [] is_a: GO:0006383 ! transcription from RNA polymerase III promoter is_a: GO:0009304 ! tRNA transcription [Term] id: GO:0042798 name: protein neddylation during NEDD8 class-dependent protein catabolic process namespace: biological_process def: "OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism." [GOC:jl] comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction. synonym: "protein neddylation during NEDD8 class-dependent protein breakdown" EXACT [] synonym: "protein neddylation during NEDD8 class-dependent protein catabolism" EXACT [] synonym: "protein neddylation during NEDD8 class-dependent protein degradation" EXACT [] synonym: "protein neddylation during RUB1-dependent protein catabolic process" EXACT [] synonym: "protein neddylation during RUB1-dependent protein catabolism" EXACT [] is_obsolete: true consider: GO:0045116 [Term] id: GO:0042799 name: histone methyltransferase activity (H4-K20 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618] comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies. synonym: "histone H4 lysine 20-specific methyltransferase activity" EXACT [] synonym: "histone lysine N-methyltransferase activity (H4-K20 specific)" EXACT [] synonym: "histone methylase activity (H4-K20 specific)" EXACT [GOC:mah] is_a: GO:0018024 ! histone-lysine N-methyltransferase activity [Term] id: GO:0042800 name: histone methyltransferase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12086618] comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies. synonym: "histone H3 lysine 4-specific methyltransferase activity" EXACT [] synonym: "histone lysine N-methyltransferase activity (H3-K4 specific)" EXACT [] synonym: "histone methylase activity (H3-K4 specific)" EXACT [GOC:mah] xref: Reactome:81583 "histone methyltransferase activity (H3-K4 specific)" is_a: GO:0018024 ! histone-lysine N-methyltransferase activity [Term] id: GO:0042801 name: polo kinase kinase activity namespace: molecular_function def: "Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins." [GOC:ma] is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity [Term] id: GO:0042802 name: identical protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] subset: gosubset_prok synonym: "isoform-specific homophilic binding" EXACT [PMID:17889655] synonym: "protein homopolymerization" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042803 name: protein homodimerization activity namespace: molecular_function def: "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] subset: gosubset_prok synonym: "dimerization activity" BROAD [] is_a: GO:0042802 ! identical protein binding is_a: GO:0046983 ! protein dimerization activity [Term] id: GO:0042804 name: protein homooligomerization activity namespace: molecular_function def: "OBSOLETE. Interacting selectively with identical proteins to form a homooligomer." [GOC:jl] comment: This term was made obsolete because it represents a biological process. synonym: "oligomerization activity" BROAD [] is_obsolete: true replaced_by: GO:0051260 [Term] id: GO:0042805 name: actinin binding namespace: molecular_function def: "Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0042806 name: fucose binding namespace: molecular_function def: "Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose." [CHEBI:33984, ISBN:0582227089] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0042807 name: central vacuole namespace: cellular_component def: "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [http://www.wikipedia.org/Vacuole, ISBN:9780815341116] is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0042808 name: neuronal Cdc2-like kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics." [GOC:jl, PMID:10721722] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0042809 name: vitamin D receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes." [GOC:jl, PMID:12637589] synonym: "calciferol receptor binding" NARROW [] synonym: "VDR binding" EXACT [] is_a: GO:0008134 ! transcription factor binding is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0042810 name: pheromone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "pheromone metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0042811 name: pheromone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pheromone anabolism" EXACT [] synonym: "pheromone biosynthesis" EXACT [] synonym: "pheromone formation" EXACT [] synonym: "pheromone synthesis" EXACT [] is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0042810 ! pheromone metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0042812 name: pheromone catabolic process namespace: biological_process alt_id: GO:0007327 alt_id: GO:0046614 def: "The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pheromone breakdown" EXACT [] synonym: "pheromone catabolism" EXACT [] synonym: "pheromone degradation" EXACT [] is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042810 ! pheromone metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0042813 name: Wnt receptor activity namespace: molecular_function def: "Combining with a member of the Wnt family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] synonym: "frizzled receptor activity" RELATED [] synonym: "frizzled-2 receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0042814 name: monopolar cell growth namespace: biological_process def: "Polarized growth from one end of a cell." [GOC:vw] synonym: "monopolar cell elongation" NARROW [] synonym: "monopolar growth" BROAD [] synonym: "polar cell elongation" NARROW [] is_a: GO:0009826 ! unidimensional cell growth [Term] id: GO:0042815 name: bipolar cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell." [GOC:vw] comment: Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term 'establishment or maintenance of bipolar cell polarity resulting in cell shape ; GO:0061246' and its children. synonym: "bipolar cell elongation" NARROW [] synonym: "bipolar growth" BROAD [] synonym: "polar cell elongation" RELATED [] is_a: GO:0009826 ! unidimensional cell growth [Term] id: GO:0042816 name: vitamin B6 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "vitamin B6 metabolism" EXACT [] xref: Reactome:964975 "Vitamins B6 activation to pyridoxal phosphate" is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0042817 name: pyridoxal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, http://www.mblab.gla.ac.uk/] subset: gosubset_prok synonym: "pyridoxal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0042816 ! vitamin B6 metabolic process [Term] id: GO:0042818 name: pyridoxamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [CHEBI:16410, GOC:jl] subset: gosubset_prok synonym: "pyridoxamine metabolism" EXACT [] is_a: GO:0042816 ! vitamin B6 metabolic process [Term] id: GO:0042819 name: vitamin B6 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "vitamin B6 anabolism" EXACT [] synonym: "vitamin B6 biosynthesis" EXACT [] synonym: "vitamin B6 formation" EXACT [] synonym: "vitamin B6 synthesis" EXACT [] is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042816 ! vitamin B6 metabolic process [Term] id: GO:0042820 name: vitamin B6 catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "vitamin B6 breakdown" EXACT [] synonym: "vitamin B6 catabolism" EXACT [] synonym: "vitamin B6 degradation" EXACT [] is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0042821 name: pyridoxal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds." [GOC:jl, http://www.mblab.gla.ac.uk/] subset: gosubset_prok synonym: "pyridoxal anabolism" EXACT [] synonym: "pyridoxal biosynthesis" EXACT [] synonym: "pyridoxal formation" EXACT [] synonym: "pyridoxal synthesis" EXACT [] is_a: GO:0042817 ! pyridoxal metabolic process is_a: GO:0042819 ! vitamin B6 biosynthetic process [Term] id: GO:0042822 name: pyridoxal phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] subset: gosubset_prok synonym: "active vitamin B6 metabolic process" EXACT [] synonym: "active vitamin B6 metabolism" EXACT [] synonym: "pyridoxal phosphate metabolism" EXACT [] is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0042823 name: pyridoxal phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] subset: gosubset_prok synonym: "active vitamin B6 biosynthesis" EXACT [] synonym: "active vitamin B6 biosynthetic process" EXACT [] synonym: "pyridoxal phosphate anabolism" EXACT [] synonym: "pyridoxal phosphate biosynthesis" EXACT [] synonym: "pyridoxal phosphate formation" EXACT [] synonym: "pyridoxal phosphate synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042819 ! vitamin B6 biosynthetic process is_a: GO:0042822 ! pyridoxal phosphate metabolic process [Term] id: GO:0042824 name: MHC class I peptide loading complex namespace: cellular_component def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934] comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi. subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0030176 ! integral to endoplasmic reticulum membrane [Term] id: GO:0042825 name: TAP complex namespace: cellular_component def: "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934] synonym: "transporter associated with antigen presentation" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0042824 ! MHC class I peptide loading complex [Term] id: GO:0042826 name: histone deacetylase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0042827 name: platelet dense granule namespace: cellular_component def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682, PMID:11487378] synonym: "bull's eye body" EXACT [] synonym: "platelet dense body" EXACT [] is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0042832 name: defense response to protozoan namespace: biological_process def: "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl] synonym: "defence response to pathogenic protozoa" EXACT [] synonym: "defence response to protozoa" EXACT [] synonym: "defence response to protozoon" EXACT [] synonym: "defense response to pathogenic protozoa" EXACT [] synonym: "defense response to protozoa" EXACT [] synonym: "defense response to protozoon" EXACT [] is_a: GO:0001562 ! response to protozoan is_a: GO:0006952 ! defense response [Term] id: GO:0042834 name: peptidoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] subset: gosubset_prok is_a: GO:0005539 ! glycosaminoglycan binding [Term] id: GO:0042835 name: BRE binding namespace: molecular_function def: "Interacting selectively and non-covalently with the RNA element BRE (Bruno response element)." [PMID:10893231] is_a: GO:0003723 ! RNA binding [Term] id: GO:0042836 name: D-glucarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-glucarate metabolism" EXACT [] synonym: "saccharate metabolic process" EXACT [] synonym: "saccharate metabolism" EXACT [] is_a: GO:0019392 ! glucarate metabolic process [Term] id: GO:0042837 name: D-glucarate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-glucarate anabolism" EXACT [] synonym: "D-glucarate biosynthesis" EXACT [] synonym: "D-glucarate formation" EXACT [] synonym: "D-glucarate synthesis" EXACT [] synonym: "saccharate biosynthesis" EXACT [] synonym: "saccharate biosynthetic process" EXACT [] is_a: GO:0019393 ! glucarate biosynthetic process is_a: GO:0042836 ! D-glucarate metabolic process [Term] id: GO:0042838 name: D-glucarate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-glucarate breakdown" EXACT [] synonym: "D-glucarate catabolism" EXACT [] synonym: "D-glucarate degradation" EXACT [] synonym: "saccharate catabolic process" EXACT [] synonym: "saccharate catabolism" EXACT [] is_a: GO:0019394 ! glucarate catabolic process is_a: GO:0042836 ! D-glucarate metabolic process [Term] id: GO:0042839 name: D-glucuronate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-glucuronate metabolism" EXACT [] is_a: GO:0019585 ! glucuronate metabolic process [Term] id: GO:0042840 name: D-glucuronate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-glucuronate breakdown" EXACT [] synonym: "D-glucuronate catabolism" EXACT [] synonym: "D-glucuronate degradation" EXACT [] is_a: GO:0006064 ! glucuronate catabolic process is_a: GO:0042839 ! D-glucuronate metabolic process [Term] id: GO:0042841 name: D-glucuronate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-glucuronate anabolism" EXACT [] synonym: "D-glucuronate biosynthesis" EXACT [] synonym: "D-glucuronate formation" EXACT [] synonym: "D-glucuronate synthesis" EXACT [] is_a: GO:0042839 ! D-glucuronate metabolic process is_a: GO:0046399 ! glucuronate biosynthetic process [Term] id: GO:0042842 name: D-xylose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-xylose anabolism" EXACT [] synonym: "D-xylose biosynthesis" EXACT [] synonym: "D-xylose formation" EXACT [] synonym: "D-xylose synthesis" EXACT [] is_a: GO:0019322 ! pentose biosynthetic process is_a: GO:0042732 ! D-xylose metabolic process [Term] id: GO:0042843 name: D-xylose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-xylose breakdown" EXACT [] synonym: "D-xylose catabolism" EXACT [] synonym: "D-xylose degradation" EXACT [] is_a: GO:0019323 ! pentose catabolic process is_a: GO:0042732 ! D-xylose metabolic process [Term] id: GO:0042844 name: glycol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule." [http://www.cogsci.princeton.edu/~wn/] subset: gosubset_prok synonym: "dihydric alcohol metabolic process" BROAD [] synonym: "dihydric alcohol metabolism" BROAD [] synonym: "glycol metabolism" EXACT [] is_a: GO:0034311 ! diol metabolic process [Term] id: GO:0042845 name: glycol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule." [http://www.cogsci.princeton.edu/~wn/] subset: gosubset_prok synonym: "dihydric alcohol biosynthesis" BROAD [] synonym: "dihydric alcohol biosynthetic process" BROAD [] synonym: "glycol anabolism" EXACT [] synonym: "glycol biosynthesis" EXACT [] synonym: "glycol formation" EXACT [] synonym: "glycol synthesis" EXACT [] is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0042844 ! glycol metabolic process [Term] id: GO:0042846 name: glycol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule." [http://www.cogsci.princeton.edu/~wn/] subset: gosubset_prok synonym: "dihydric alcohol catabolic process" BROAD [] synonym: "dihydric alcohol catabolism" BROAD [] synonym: "glycol breakdown" EXACT [] synonym: "glycol catabolism" EXACT [] synonym: "glycol degradation" EXACT [] is_a: GO:0034313 ! diol catabolic process is_a: GO:0042844 ! glycol metabolic process [Term] id: GO:0042847 name: sorbose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sorbose anabolism" EXACT [] synonym: "sorbose biosynthesis" EXACT [] synonym: "sorbose formation" EXACT [] synonym: "sorbose synthesis" EXACT [] is_a: GO:0019311 ! sorbose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0042848 name: sorbose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sorbose breakdown" EXACT [] synonym: "sorbose catabolism" EXACT [] synonym: "sorbose degradation" EXACT [] is_a: GO:0019311 ! sorbose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0042849 name: L-sorbose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [CHEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-sorbose anabolism" EXACT [] synonym: "L-sorbose biosynthesis" EXACT [] synonym: "L-sorbose formation" EXACT [] synonym: "L-sorbose synthesis" EXACT [] is_a: GO:0019312 ! L-sorbose metabolic process is_a: GO:0042847 ! sorbose biosynthetic process [Term] id: GO:0042850 name: L-sorbose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose." [CHEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-sorbose breakdown" EXACT [] synonym: "L-sorbose catabolism" EXACT [] synonym: "L-sorbose degradation" EXACT [] is_a: GO:0019312 ! L-sorbose metabolic process is_a: GO:0042848 ! sorbose catabolic process [Term] id: GO:0042851 name: L-alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [CHEBI:16977, GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-alanine metabolism" EXACT [] is_a: GO:0006522 ! alanine metabolic process [Term] id: GO:0042852 name: L-alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [CHEBI:16977, GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-alanine anabolism" EXACT [] synonym: "L-alanine biosynthesis" EXACT [] synonym: "L-alanine formation" EXACT [] synonym: "L-alanine synthesis" EXACT [] is_a: GO:0006523 ! alanine biosynthetic process is_a: GO:0042851 ! L-alanine metabolic process [Term] id: GO:0042853 name: L-alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [CHEBI:16977, GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-alanine breakdown" EXACT [] synonym: "L-alanine catabolism" EXACT [] synonym: "L-alanine degradation" EXACT [] is_a: GO:0006524 ! alanine catabolic process is_a: GO:0042851 ! L-alanine metabolic process [Term] id: GO:0042854 name: eugenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [CHEBI:4917, GOC:jl] subset: gosubset_prok synonym: "4-allyl-2-methoxyphenol metabolic process" EXACT [] synonym: "4-allyl-2-methoxyphenol metabolism" EXACT [] synonym: "eugenic acid metabolic process" EXACT [] synonym: "eugenic acid metabolism" EXACT [] synonym: "eugenol metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0042855 name: eugenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [CHEBI:4917, GOC:jl] subset: gosubset_prok synonym: "4-allyl-2-methoxyphenol biosynthesis" EXACT [] synonym: "4-allyl-2-methoxyphenol biosynthetic process" EXACT [] synonym: "eugenic acid biosynthesis" EXACT [] synonym: "eugenic acid biosynthetic process" EXACT [] synonym: "eugenol anabolism" EXACT [] synonym: "eugenol biosynthesis" EXACT [] synonym: "eugenol formation" EXACT [] synonym: "eugenol synthesis" EXACT [] is_a: GO:0042854 ! eugenol metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0042856 name: eugenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [CHEBI:4917, GOC:jl] subset: gosubset_prok synonym: "4-allyl-2-methoxyphenol catabolic process" EXACT [] synonym: "4-allyl-2-methoxyphenol catabolism" EXACT [] synonym: "eugenic acid catabolic process" EXACT [] synonym: "eugenic acid catabolism" EXACT [] synonym: "eugenol breakdown" EXACT [] synonym: "eugenol catabolism" EXACT [] synonym: "eugenol degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042854 ! eugenol metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0042857 name: chrysobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] subset: gosubset_prok synonym: "chrysobactin metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0042858 name: chrysobactin biosynthetic process namespace: biological_process alt_id: GO:0031183 alt_id: GO:0031184 def: "The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] subset: gosubset_prok synonym: "chrysobactin anabolism" EXACT [] synonym: "chrysobactin biosynthesis" EXACT [] synonym: "chrysobactin biosynthetic process, peptide formation" NARROW [] synonym: "chrysobactin biosynthetic process, peptide modification" NARROW [] synonym: "chrysobactin formation" EXACT [] synonym: "chrysobactin synthesis" EXACT [] is_a: GO:0019290 ! siderophore biosynthetic process is_a: GO:0042857 ! chrysobactin metabolic process [Term] id: GO:0042859 name: chrysobactin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] subset: gosubset_prok synonym: "chrysobactin breakdown" EXACT [] synonym: "chrysobactin catabolism" EXACT [] synonym: "chrysobactin degradation" EXACT [] is_a: GO:0042857 ! chrysobactin metabolic process is_a: GO:0046215 ! siderophore catabolic process [Term] id: GO:0042860 name: achromobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] subset: gosubset_prok synonym: "achromobactin metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0042861 name: achromobactin biosynthetic process namespace: biological_process alt_id: GO:0031181 alt_id: GO:0031182 def: "The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] subset: gosubset_prok synonym: "achromobactin anabolism" EXACT [] synonym: "achromobactin biosynthesis" EXACT [] synonym: "achromobactin biosynthetic process, peptide formation" NARROW [] synonym: "achromobactin biosynthetic process, peptide modification" NARROW [] synonym: "achromobactin formation" EXACT [] synonym: "achromobactin synthesis" EXACT [] is_a: GO:0019290 ! siderophore biosynthetic process is_a: GO:0042860 ! achromobactin metabolic process [Term] id: GO:0042862 name: achromobactin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] subset: gosubset_prok synonym: "achromobactin breakdown" EXACT [] synonym: "achromobactin catabolism" EXACT [] synonym: "achromobactin degradation" EXACT [] is_a: GO:0042860 ! achromobactin metabolic process is_a: GO:0046215 ! siderophore catabolic process [Term] id: GO:0042863 name: pyochelin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] subset: gosubset_prok synonym: "pyochelin metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0042864 name: pyochelin biosynthetic process namespace: biological_process alt_id: GO:0031187 alt_id: GO:0031188 def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] subset: gosubset_prok synonym: "pyochelin anabolism" EXACT [] synonym: "pyochelin biosynthesis" EXACT [] synonym: "pyochelin biosynthetic process, peptide formation" NARROW [] synonym: "pyochelin biosynthetic process, peptide modification" NARROW [] synonym: "pyochelin formation" EXACT [] synonym: "pyochelin synthesis" EXACT [] is_a: GO:0019290 ! siderophore biosynthetic process is_a: GO:0042863 ! pyochelin metabolic process [Term] id: GO:0042865 name: pyochelin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] subset: gosubset_prok synonym: "pyochelin breakdown" EXACT [] synonym: "pyochelin catabolism" EXACT [] synonym: "pyochelin degradation" EXACT [] is_a: GO:0042863 ! pyochelin metabolic process is_a: GO:0046215 ! siderophore catabolic process [Term] id: GO:0042866 name: pyruvate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate." [GOC:go_curators] subset: gosubset_prok synonym: "pyruvate anabolism" EXACT [] synonym: "pyruvate biosynthesis" EXACT [] synonym: "pyruvate formation" EXACT [] synonym: "pyruvate synthesis" EXACT [] is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0042867 name: pyruvate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate." [GOC:go_curators] subset: gosubset_prok synonym: "pyruvate breakdown" EXACT [] synonym: "pyruvate catabolism" EXACT [] synonym: "pyruvate degradation" EXACT [] is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0042868 name: antisense RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis." [GOC:jl] subset: gosubset_prok synonym: "antisense RNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0042869 name: aldarate transport namespace: biological_process def: "The directed movement of aldarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0042870 name: D-glucarate transport namespace: biological_process def: "The directed movement of D-glucarate, the D-enantiomer of glucarate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042869 ! aldarate transport [Term] id: GO:0042871 name: D-galactarate transport namespace: biological_process def: "The directed movement of D-galactarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. D-galactarate is the D-enantiomer of galactarate, the anion of galactaric acid." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0042869 ! aldarate transport [Term] id: GO:0042872 name: D-galactarate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-galactarate, the D-enantiomer of the anion of galactaric acid." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-galactarate anabolism" EXACT [] synonym: "D-galactarate biosynthesis" EXACT [] synonym: "D-galactarate formation" EXACT [] synonym: "D-galactarate synthesis" EXACT [] is_a: GO:0046357 ! galactarate biosynthetic process is_a: GO:0046393 ! D-galactarate metabolic process [Term] id: GO:0042873 name: aldonate transport namespace: biological_process def: "The directed movement of aldonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] subset: gosubset_prok is_a: GO:0008645 ! hexose transport [Term] id: GO:0042874 name: D-glucuronate transport namespace: biological_process def: "The directed movement of D-glucuronate, the D-enantiomer of glucuronate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] is_a: GO:0042873 ! aldonate transport [Term] id: GO:0042875 name: D-galactonate transport namespace: biological_process def: "The directed movement of D-galactonate, the D-enantiomer of galactonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok is_a: GO:0042873 ! aldonate transport [Term] id: GO:0042876 name: aldarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of aldarate from one side of the membrane to the other." [GOC:go_curators, PMID:15034926] subset: gosubset_prok is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0042877 name: D-galactarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-galactarate, the D-enantiomer of the anion of galactaric acid, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok is_a: GO:0042876 ! aldarate transmembrane transporter activity [Term] id: GO:0042878 name: D-glucarate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok is_a: GO:0042876 ! aldarate transmembrane transporter activity [Term] id: GO:0042879 name: aldonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of aldonate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0042880 name: D-glucuronate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok is_a: GO:0042879 ! aldonate transmembrane transporter activity [Term] id: GO:0042881 name: D-galactonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] is_a: GO:0042879 ! aldonate transmembrane transporter activity [Term] id: GO:0042882 name: L-arabinose transport namespace: biological_process def: "The directed movement of L-arabinose, the L-enantiomer of arabinose, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015751 ! arabinose transport [Term] id: GO:0042883 name: cysteine transport namespace: biological_process def: "The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-cysteine transport" NARROW [] is_a: GO:0000101 ! sulfur amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0042884 name: microcin transport namespace: biological_process def: "The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11292337] subset: gosubset_prok is_a: GO:0015833 ! peptide transport is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0042885 name: microcin B17 transport namespace: biological_process def: "The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:11292337] subset: gosubset_prok is_a: GO:0042884 ! microcin transport [Term] id: GO:0042886 name: amide transport namespace: biological_process def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0042887 name: amide transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amine/amide/polyamine channel activity" NARROW [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0042888 name: molybdenum ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of molybdenum (Mo) ions from one side of a membrane to the other." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0042889 name: 3-phenylpropionic acid transport namespace: biological_process def: "The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] subset: gosubset_prok synonym: "3-phenylpropionate transport" EXACT [] synonym: "HCA transport" EXACT [] synonym: "hydrocinnamic acid transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0042890 name: 3-phenylpropionic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of 3-phenylpropionic acid from one side of the membrane to the other." [GOC:jl] synonym: "3-phenylpropionate acid transporter activity" EXACT [] synonym: "HCA transporter activity" EXACT [] synonym: "hydrocinnamic acid transporter activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0042891 name: antibiotic transport namespace: biological_process def: "The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] subset: gosubset_prok is_a: GO:0015893 ! drug transport [Term] id: GO:0042892 name: chloramphenicol transport namespace: biological_process def: "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17698, GOC:jl] subset: gosubset_prok is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0042893 name: polymyxin transport namespace: biological_process def: "The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0042894 name: fosmidomycin transport namespace: biological_process def: "The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:12543685] subset: gosubset_prok is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0042895 name: antibiotic transporter activity namespace: molecular_function def: "Enables the directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells." [GOC:jl] subset: gosubset_prok is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0042896 name: chloramphenicol transporter activity namespace: molecular_function def: "Enables the directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of or within a cell, or between cells." [CHEBI:17698, GOC:jl] subset: gosubset_prok is_a: GO:0042895 ! antibiotic transporter activity [Term] id: GO:0042897 name: polymyxin transporter activity namespace: molecular_function def: "Enables the directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0042895 ! antibiotic transporter activity [Term] id: GO:0042898 name: fosmidomycin transporter activity namespace: molecular_function def: "Enables the directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells." [GOC:jl, PMID:12543685] subset: gosubset_prok is_a: GO:0042895 ! antibiotic transporter activity [Term] id: GO:0042899 name: arabinose polymer transport namespace: biological_process def: "The directed movement of an arabinose polymer, a repeating chain of arabinose monomers, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] subset: gosubset_prok is_a: GO:0015751 ! arabinose transport [Term] id: GO:0042900 name: arabinose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of the membrane to the other." [CHEBI:22599, GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015146 ! pentose transmembrane transporter activity [Term] id: GO:0042901 name: arabinose polymer transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an arabinose polymer, a repeating chain of arabinose monomers, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0042900 ! arabinose transmembrane transporter activity [Term] id: GO:0042902 name: peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein namespace: biological_process def: "The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [RESID:AA0345] subset: gosubset_prok xref: RESID:AA0345 is_a: GO:0018104 ! peptidoglycan-protein cross-linking is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0042903 name: tubulin deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate." [PMID:12024216, PMID:12486003] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0033558 ! protein deacetylase activity [Term] id: GO:0042904 name: 9-cis-retinoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029] subset: gosubset_prok synonym: "9-cis-retinoic acid anabolism" EXACT [] synonym: "9-cis-retinoic acid biosynthesis" EXACT [] synonym: "9-cis-retinoic acid formation" EXACT [] synonym: "9-cis-retinoic acid synthesis" EXACT [] is_a: GO:0035238 ! vitamin A biosynthetic process is_a: GO:0042905 ! 9-cis-retinoic acid metabolic process [Term] id: GO:0042905 name: 9-cis-retinoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029] subset: gosubset_prok synonym: "9-cis-retinoic acid metabolism" EXACT [] is_a: GO:0042573 ! retinoic acid metabolic process [Term] id: GO:0042906 name: xanthine transport namespace: biological_process def: "The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl] synonym: "xanthine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine base transport [Term] id: GO:0042907 name: xanthine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl] is_a: GO:0005345 ! purine base transmembrane transporter activity [Term] id: GO:0042908 name: xenobiotic transport namespace: biological_process def: "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0042909 name: acridine transport namespace: biological_process def: "The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:36420, GOC:jl, http://www.wikipedia.org/Acridine] subset: gosubset_prok is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0042910 name: xenobiotic transporter activity namespace: molecular_function def: "Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells." [GOC:go_curators] subset: gosubset_prok is_a: GO:0005215 ! transporter activity [Term] id: GO:0042911 name: acridine transporter activity namespace: molecular_function def: "Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells." [CHEBI:36420, GOC:jl] subset: gosubset_prok is_a: GO:0042910 ! xenobiotic transporter activity [Term] id: GO:0042912 name: colicin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:17347522] subset: gosubset_prok is_a: GO:0022885 ! bacteriocin transmembrane transporter activity [Term] id: GO:0042913 name: group A colicin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417] subset: gosubset_prok is_a: GO:0042912 ! colicin transmembrane transporter activity [Term] id: GO:0042914 name: colicin transport namespace: biological_process def: "The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, PMID:17347522] subset: gosubset_prok is_a: GO:0043213 ! bacteriocin transport [Term] id: GO:0042915 name: group A colicin transport namespace: biological_process def: "The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:9171417] subset: gosubset_prok is_a: GO:0042914 ! colicin transport [Term] id: GO:0042916 name: alkylphosphonate transport namespace: biological_process def: "The directed movement of an alkylphosphonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] subset: gosubset_prok is_a: GO:0015716 ! phosphonate transport [Term] id: GO:0042917 name: alkylphosphonate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of an alkylphosphonate from one side of a membrane to the other." [GOC:go_curators] subset: gosubset_prok is_a: GO:0015604 ! phosphonate transmembrane transporter activity [Term] id: GO:0042918 name: alkanesulfonate transport namespace: biological_process def: "The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical." [CHEBI:22318, GOC:jl] subset: gosubset_prok synonym: "alkanesulphonate transport" EXACT [] is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0042919 name: benzoate transport namespace: biological_process def: "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0042920 name: 3-hydroxyphenylpropionic acid transport namespace: biological_process def: "The directed movement of 3-hydroxyphenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] subset: gosubset_prok synonym: "3-(3-hydroxyphenyl)propionic acid transport" EXACT [] synonym: "m-hydroxyphenylpropionic acid transport" EXACT [] is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0042921 name: glucocorticoid receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor." [GOC:mah] synonym: "glucocorticoid receptor signalling pathway" EXACT [] is_a: GO:0031958 ! corticosteroid receptor signaling pathway [Term] id: GO:0042922 name: neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor." [GOC:jl, PMID:10899166] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0042923 name: neuropeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html] is_a: GO:0042277 ! peptide binding [Term] id: GO:0042924 name: neuromedin U binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses." [GOC:jl, PMID:12584108] synonym: "NMU binding" EXACT [] is_a: GO:0042923 ! neuropeptide binding [Term] id: GO:0042925 name: benzoate transporter activity namespace: molecular_function def: "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok is_a: GO:0042910 ! xenobiotic transporter activity [Term] id: GO:0042926 name: 3-hydroxyphenylpropionic acid transporter activity namespace: molecular_function def: "Enables the directed movement of 3-hydroxyphenylpropionic acid into, out of or within a cell, or between cells." [GOC:jl] subset: gosubset_prok synonym: "3-(3-hydroxyphenyl)propionic acid transporter activity" EXACT [] synonym: "m-hydroxyphenylpropionic acid transporter activity" EXACT [] is_a: GO:0042910 ! xenobiotic transporter activity [Term] id: GO:0042927 name: siderophore transporter activity namespace: molecular_function def: "Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells." [GOC:go_curators] subset: gosubset_prok synonym: "siderochrome transporter activity" NARROW [] synonym: "siderophore-iron transporter activity" RELATED [] is_a: GO:0005215 ! transporter activity [Term] id: GO:0042928 name: ferrichrome transport namespace: biological_process def: "The directed movement of a ferrichrome into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015891 ! siderophore transport [Term] id: GO:0042929 name: ferrichrome transporter activity namespace: molecular_function def: "Enables the directed movement of a ferrichrome into, out of or within a cell, or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0042927 ! siderophore transporter activity [Term] id: GO:0042930 name: enterobactin transport namespace: biological_process def: "The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:28855, GOC:jl] subset: gosubset_prok synonym: "enterochelin transport" EXACT [] is_a: GO:0015891 ! siderophore transport [Term] id: GO:0042931 name: enterobactin transporter activity namespace: molecular_function def: "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells." [CHEBI:28855, GOC:jl] subset: gosubset_prok synonym: "enterochelin transporter activity" EXACT [] is_a: GO:0042927 ! siderophore transporter activity [Term] id: GO:0042932 name: chrysobactin transport namespace: biological_process def: "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:8837459] subset: gosubset_prok is_a: GO:0015891 ! siderophore transport [Term] id: GO:0042933 name: chrysobactin transporter activity namespace: molecular_function def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells." [GOC:jl, PMID:8837459] subset: gosubset_prok is_a: GO:0042927 ! siderophore transporter activity [Term] id: GO:0042934 name: achromobactin transporter activity namespace: molecular_function def: "Enables the directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells." [GOC:jl] subset: gosubset_prok is_a: GO:0042927 ! siderophore transporter activity is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0042935 name: achromobactin transport namespace: biological_process def: "The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:10928541] subset: gosubset_prok is_a: GO:0015891 ! siderophore transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0042936 name: dipeptide transporter activity namespace: molecular_function def: "Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells." [CHEBI:46761, GOC:jl] subset: gosubset_prok is_a: GO:0015198 ! oligopeptide transporter activity [Term] id: GO:0042937 name: tripeptide transporter activity namespace: molecular_function def: "Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells." [CHEBI:47923, GOC:jl] subset: gosubset_prok is_a: GO:0015198 ! oligopeptide transporter activity [Term] id: GO:0042938 name: dipeptide transport namespace: biological_process def: "The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:46761, GOC:jl] subset: gosubset_prok is_a: GO:0006857 ! oligopeptide transport [Term] id: GO:0042939 name: tripeptide transport namespace: biological_process def: "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:47923, GOC:jl] subset: gosubset_prok is_a: GO:0006857 ! oligopeptide transport [Term] id: GO:0042940 name: D-amino acid transport namespace: biological_process def: "The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport [Term] id: GO:0042941 name: D-alanine transport namespace: biological_process def: "The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:15570, GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok is_a: GO:0032328 ! alanine transport is_a: GO:0042940 ! D-amino acid transport [Term] id: GO:0042942 name: D-serine transport namespace: biological_process def: "The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok is_a: GO:0032329 ! serine transport is_a: GO:0042940 ! D-amino acid transport [Term] id: GO:0042943 name: D-amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0042944 name: D-alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid." [CHEBI:15570, GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-alanine transporter activity" BROAD [] is_a: GO:0022858 ! alanine transmembrane transporter activity is_a: GO:0042943 ! D-amino acid transmembrane transporter activity [Term] id: GO:0042945 name: D-serine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-serine permease activity" EXACT [] synonym: "D-serine transporter activity" BROAD [] is_a: GO:0022889 ! serine transmembrane transporter activity is_a: GO:0042943 ! D-amino acid transmembrane transporter activity [Term] id: GO:0042946 name: glucoside transport namespace: biological_process def: "The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0042947 name: glucoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0051119 ! sugar transmembrane transporter activity [Term] id: GO:0042948 name: salicin transport namespace: biological_process def: "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17814, GOC:jl] subset: gosubset_prok is_a: GO:0015759 ! beta-glucoside transport [Term] id: GO:0042949 name: arbutin transport namespace: biological_process def: "The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://biotech.icmb.utexas.edu/] is_a: GO:0015759 ! beta-glucoside transport [Term] id: GO:0042950 name: salicin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of the membrane to the other." [CHEBI:17814, GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity [Term] id: GO:0042951 name: arbutin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://biotech.icmb.utexas.edu/, ISBN:0815340729] is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity [Term] id: GO:0042952 name: beta-ketoadipate pathway namespace: biological_process def: "A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates." [GOC:jl, PMID:8905091] subset: gosubset_prok synonym: "ortho-cleavage pathway" BROAD [] is_a: GO:0019439 ! aromatic compound catabolic process [Term] id: GO:0042953 name: lipoprotein transport namespace: biological_process def: "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015031 ! protein transport [Term] id: GO:0042954 name: lipoprotein transporter activity namespace: molecular_function def: "Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008565 ! protein transporter activity [Term] id: GO:0042955 name: dextrin transport namespace: biological_process def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/] subset: gosubset_prok is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0042956 name: maltodextrin transport namespace: biological_process def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/] subset: gosubset_prok is_a: GO:0042955 ! dextrin transport [Term] id: GO:0042957 name: dextrin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of the membrane to the other." [GOC:jl, GOC:vk, http://www.mercksource.com/] subset: gosubset_prok is_a: GO:0015159 ! polysaccharide transmembrane transporter activity [Term] id: GO:0042958 name: maltodextrin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of the membrane to the other." [GOC:jl, http://www.mercksource.com/, PMID:15034926] subset: gosubset_prok is_a: GO:0042957 ! dextrin transmembrane transporter activity [Term] id: GO:0042959 name: alkanesulfonate transporter activity namespace: molecular_function def: "Enables the directed movement of alkanesulfonate into, out of or within a cell, or between cells." [GOC:jl] subset: gosubset_prok synonym: "alkanesulphonate transporter activity" EXACT [] is_a: GO:0042910 ! xenobiotic transporter activity [Term] id: GO:0042960 name: antimonite secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl] subset: gosubset_prok synonym: "antimonite porter activity" RELATED [] is_a: GO:0015104 ! antimonite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0042961 name: antimonite-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:3.6.3.16] subset: gosubset_prok synonym: "antimonite ABC transporter" NARROW [] is_a: GO:0042960 ! antimonite secondary active transmembrane transporter activity is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity [Term] id: GO:0042962 name: acridine:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)." [PMID:10735876] subset: gosubset_prok synonym: "acridine efflux pump activity" RELATED [] synonym: "acridine:proton antiporter activity" EXACT [] is_a: GO:0015299 ! solute:hydrogen antiporter activity is_a: GO:0042911 ! acridine transporter activity [Term] id: GO:0042963 name: phage assembly namespace: biological_process def: "A late phase of bacteriophage replication during which all the components necessary for the formation of a mature virion collect at a particular site in the bacterial cell and the basic structure of the virus particle is formed." [GOC:go_curators] synonym: "bacteriophage assembly" EXACT [] is_a: GO:0019068 ! virion assembly [Term] id: GO:0042964 name: thioredoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase." [GOC:go_curators] subset: gosubset_prok synonym: "thioredoxin anabolism" EXACT [] synonym: "thioredoxin biosynthesis" EXACT [] synonym: "thioredoxin formation" EXACT [] synonym: "thioredoxin synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0042965 name: glutaredoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:go_curators] subset: gosubset_prok synonym: "glutaredoxin anabolism" EXACT [] synonym: "glutaredoxin biosynthesis" EXACT [] synonym: "glutaredoxin formation" EXACT [] synonym: "glutaredoxin synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0042966 name: biotin carboxyl carrier protein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase." [GOC:go_curators, PMID:8102363] subset: gosubset_prok synonym: "BCCP biosynthesis" EXACT [] synonym: "BCCP biosynthetic process" EXACT [] synonym: "biotin carboxyl carrier protein anabolism" EXACT [] synonym: "biotin carboxyl carrier protein biosynthesis" EXACT [] synonym: "biotin carboxyl carrier protein formation" EXACT [] synonym: "biotin carboxyl carrier protein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0042967 name: acyl-carrier-protein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acyl-carrier protein." [GOC:go_curators] subset: gosubset_prok synonym: "ACP biosynthesis" EXACT [] synonym: "ACP biosynthetic process" EXACT [] synonym: "acyl carrier protein biosynthesis" EXACT [] synonym: "acyl carrier protein biosynthetic process" EXACT [] synonym: "acyl-carrier protein biosynthesis" EXACT [] synonym: "acyl-carrier-protein anabolism" EXACT [] synonym: "acyl-carrier-protein biosynthesis" EXACT [] synonym: "acyl-carrier-protein formation" EXACT [] synonym: "acyl-carrier-protein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0042968 name: homoserine transport namespace: biological_process def: "The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0042969 name: lactone transport namespace: biological_process def: "The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:25000, GOC:go_curators] subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0042970 name: homoserine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "homoserine transporter activity" BROAD [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0042971 name: lactone transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:25000, GOC:go_curators] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0042972 name: licheninase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in beta-D-glucans containing 1,3- and 1,4-bonds." [EC:3.2.1.73] subset: gosubset_prok synonym: "1,3-1,4-beta-D-glucan 4-glucanohydrolase activity" EXACT [] synonym: "1,3-1,4-beta-glucan 4-glucanohydrolase activity" EXACT [] synonym: "1,3;1,4-beta-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73] synonym: "1,3;1,4-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.73] synonym: "beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73] synonym: "beta-glucanase activity" BROAD [EC:3.2.1.73] synonym: "endo-beta-1,3-1,4 glucanase activity" EXACT [EC:3.2.1.73] synonym: "lichenase activity" EXACT [] synonym: "mixed linkage beta-glucanase activity" RELATED [EC:3.2.1.73] xref: EC:3.2.1.73 xref: MetaCyc:3.2.1.73-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0042973 name: glucan endo-1,3-beta-D-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans." [EC:3.2.1.39] subset: gosubset_prok synonym: "(1->3)-beta-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39] synonym: "(1->3)-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.39] synonym: "1,3-beta-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39] synonym: "1,3-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.39] synonym: "beta-1,3-glucanase" BROAD [EC:3.2.1.39] synonym: "callase activity" EXACT [EC:3.2.1.39] synonym: "endo-(1,3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] synonym: "endo-(1->3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] synonym: "endo-1,3-beta-D-glucanase" BROAD [EC:3.2.1.39] synonym: "endo-1,3-beta-glucanase activity" BROAD [] synonym: "endo-1,3-beta-glucosidase activity" BROAD [EC:3.2.1.39] synonym: "kitalase activity" EXACT [EC:3.2.1.39] synonym: "laminaranase activity" BROAD [] synonym: "laminarinase activity" BROAD [] synonym: "oligo-1,3-glucosidase activity" RELATED [EC:3.2.1.39] xref: EC:3.2.1.39 xref: MetaCyc:3.2.1.39-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0042974 name: retinoic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily." [GOC:jl, PMID:12476796] synonym: "RAR binding" EXACT [] is_a: GO:0008134 ! transcription factor binding is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0042975 name: peroxisome proliferator activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma." [GOC:jl, PMID:12769781] synonym: "PPAR binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0042976 name: activation of Janus kinase activity namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:jl, PMID:12479803] synonym: "activation of JAK protein" EXACT [GOC:dph, GOC:tb] synonym: "activation of JAK protein by tyrosine phosphorylation" EXACT [] synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" BROAD [] synonym: "tyrosine phosphorylation of JAK protein" RELATED [] is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation is_a: GO:0032147 ! activation of protein kinase activity relationship: part_of GO:0046427 ! positive regulation of JAK-STAT cascade [Term] id: GO:0042977 name: activation of JAK2 kinase activity namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:jl, PMID:12479803] synonym: "activation of JAK2 protein" EXACT [GOC:dph, GOC:tb] synonym: "tyrosine phosphorylation of JAK2 protein" RELATED [] is_a: GO:0042976 ! activation of Janus kinase activity [Term] id: GO:0042978 name: ornithine decarboxylase activator activity namespace: molecular_function def: "Upregulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl] synonym: "L-ornithine carboxy-lyase activator activity" NARROW [] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0042979 ! ornithine decarboxylase regulator activity [Term] id: GO:0042979 name: ornithine decarboxylase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0042980 name: cystic fibrosis transmembrane conductance regulator binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein." [GOC:jl] synonym: "CFTR binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042981 name: regulation of apoptosis namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptosis." [GOC:jl] synonym: "apoptosis regulator activity" RELATED [] xref: Reactome:1253584 "Regulation of Apoptosis" xref: Reactome:1280552 "Regulation of Apoptosis" xref: Reactome:1299349 "Regulation of Apoptosis" xref: Reactome:1327102 "Regulation of Apoptosis" xref: Reactome:1353195 "Regulation of Apoptosis" xref: Reactome:1373373 "Regulation of Apoptosis" xref: Reactome:1393397 "Regulation of Apoptosis" xref: Reactome:1417893 "Regulation of Apoptosis" xref: Reactome:1450983 "Regulation of Apoptosis" xref: Reactome:1471367 "Regulation of Apoptosis" xref: Reactome:1483325 "Regulation of Apoptosis" xref: Reactome:1521266 "Regulation of Apoptosis" xref: Reactome:1526975 "Regulation of Apoptosis" xref: Reactome:1532711 "Regulation of Apoptosis" xref: Reactome:169911 "Regulation of Apoptosis" is_a: GO:0043067 ! regulation of programmed cell death relationship: regulates GO:0006915 ! apoptosis [Term] id: GO:0042982 name: amyloid precursor protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] subset: gosubset_prok synonym: "amyloid precursor protein metabolism" EXACT [] synonym: "APP metabolic process" EXACT [] synonym: "APP metabolism" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0042983 name: amyloid precursor protein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] subset: gosubset_prok synonym: "amyloid precursor protein anabolism" EXACT [] synonym: "amyloid precursor protein biosynthesis" EXACT [] synonym: "amyloid precursor protein formation" EXACT [] synonym: "amyloid precursor protein synthesis" EXACT [] synonym: "APP biosynthesis" EXACT [] synonym: "APP biosynthetic process" EXACT [] is_a: GO:0009101 ! glycoprotein biosynthetic process is_a: GO:0042982 ! amyloid precursor protein metabolic process [Term] id: GO:0042984 name: regulation of amyloid precursor protein biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of amyloid precursor protein anabolism" EXACT [] synonym: "regulation of amyloid precursor protein biosynthesis" EXACT [] synonym: "regulation of amyloid precursor protein formation" EXACT [] synonym: "regulation of amyloid precursor protein synthesis" EXACT [] synonym: "regulation of APP biosynthesis" EXACT [] synonym: "regulation of APP biosynthetic process" EXACT [] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process relationship: regulates GO:0042983 ! amyloid precursor protein biosynthetic process [Term] id: GO:0042985 name: negative regulation of amyloid precursor protein biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "down-regulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "downregulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "inhibition of amyloid precursor protein biosynthetic process" NARROW [] synonym: "negative regulation of amyloid precursor protein anabolism" EXACT [] synonym: "negative regulation of amyloid precursor protein biosynthesis" EXACT [] synonym: "negative regulation of amyloid precursor protein formation" EXACT [] synonym: "negative regulation of amyloid precursor protein synthesis" EXACT [] synonym: "negative regulation of APP biosynthesis" EXACT [] synonym: "negative regulation of APP biosynthetic process" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process relationship: negatively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process [Term] id: GO:0042986 name: positive regulation of amyloid precursor protein biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators] subset: gosubset_prok synonym: "activation of amyloid precursor protein biosynthetic process" NARROW [] synonym: "positive regulation of amyloid precursor protein anabolism" EXACT [] synonym: "positive regulation of amyloid precursor protein biosynthesis" EXACT [] synonym: "positive regulation of amyloid precursor protein formation" EXACT [] synonym: "positive regulation of amyloid precursor protein synthesis" EXACT [] synonym: "positive regulation of APP biosynthesis" EXACT [] synonym: "positive regulation of APP biosynthetic process" EXACT [] synonym: "stimulation of amyloid precursor protein biosynthetic process" NARROW [] synonym: "up regulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "up-regulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "upregulation of amyloid precursor protein biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process relationship: positively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process [Term] id: GO:0042987 name: amyloid precursor protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] synonym: "amyloid precursor protein breakdown" EXACT [] synonym: "amyloid precursor protein catabolism" EXACT [] synonym: "amyloid precursor protein degradation" EXACT [] synonym: "APP catabolic process" EXACT [] synonym: "APP catabolism" EXACT [] is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0042982 ! amyloid precursor protein metabolic process [Term] id: GO:0042988 name: X11-like protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein." [GOC:jl, PMID:12780348] synonym: "X11L binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042989 name: sequestering of actin monomers namespace: biological_process def: "The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators] synonym: "actin monomer retention" EXACT [] synonym: "actin monomer sequestering" EXACT [] synonym: "actin monomer sequestering activity" RELATED [] synonym: "actin monomer sequestration" EXACT [] synonym: "actin monomer storage" EXACT [] synonym: "retention of actin monomers" EXACT [] synonym: "sequestration of actin monomers" EXACT [] synonym: "storage of actin monomers" EXACT [] is_a: GO:0030837 ! negative regulation of actin filament polymerization is_a: GO:0045185 ! maintenance of protein location [Term] id: GO:0042990 name: regulation of transcription factor import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] synonym: "regulation of transcription factor import into cell nucleus" EXACT [] synonym: "regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of transcription factor-nucleus import" EXACT [] is_a: GO:0042306 ! regulation of protein import into nucleus relationship: regulates GO:0042991 ! transcription factor import into nucleus [Term] id: GO:0042991 name: transcription factor import into nucleus namespace: biological_process def: "The directed movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] synonym: "transcription factor import into cell nucleus" EXACT [] synonym: "transcription factor transport from cytoplasm to nucleus" EXACT [] synonym: "transcription factor-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0042992 name: negative regulation of transcription factor import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] synonym: "down regulation of transcription factor import into nucleus" EXACT [] synonym: "down-regulation of transcription factor import into nucleus" EXACT [] synonym: "downregulation of transcription factor import into nucleus" EXACT [] synonym: "inhibition of transcription factor import into nucleus" NARROW [] synonym: "negative regulation of transcription factor import into cell nucleus" EXACT [] synonym: "negative regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of transcription factor-nucleus import" EXACT [] is_a: GO:0042308 ! negative regulation of protein import into nucleus is_a: GO:0042990 ! regulation of transcription factor import into nucleus relationship: negatively_regulates GO:0042991 ! transcription factor import into nucleus [Term] id: GO:0042993 name: positive regulation of transcription factor import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] synonym: "activation of transcription factor import into nucleus" NARROW [] synonym: "positive regulation of transcription factor import into cell nucleus" EXACT [] synonym: "positive regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of transcription factor-nucleus import" EXACT [] synonym: "stimulation of transcription factor import into nucleus" NARROW [] synonym: "up regulation of transcription factor import into nucleus" EXACT [] synonym: "up-regulation of transcription factor import into nucleus" EXACT [] synonym: "upregulation of transcription factor import into nucleus" EXACT [] is_a: GO:0042307 ! positive regulation of protein import into nucleus is_a: GO:0042990 ! regulation of transcription factor import into nucleus relationship: positively_regulates GO:0042991 ! transcription factor import into nucleus [Term] id: GO:0042994 name: cytoplasmic sequestering of transcription factor namespace: biological_process def: "The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] synonym: "cytoplasmic retention of transcription factor" EXACT [] synonym: "cytoplasmic sequestration of transcription factor" EXACT [] synonym: "cytoplasmic storage of transcription factor" EXACT [] synonym: "maintenance of transcription factor protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] synonym: "retention of transcription factor in cytoplasm" EXACT [] synonym: "sequestering of transcription factor in cytoplasm" EXACT [] synonym: "sequestration of transcription factor in cytoplasm" EXACT [] synonym: "storage of transcription factor in cytoplasm" EXACT [] synonym: "transcription factor binding, cytoplasmic sequestering" EXACT [] is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus is_a: GO:0051220 ! cytoplasmic sequestering of protein [Term] id: GO:0042995 name: cell projection namespace: cellular_component def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_pir subset: gosubset_prok synonym: "cell process" BROAD [] synonym: "cellular process" BROAD [] synonym: "cellular projection" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0042996 name: regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0043001 ! Golgi to plasma membrane protein transport [Term] id: GO:0042997 name: negative regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0090317 ! negative regulation of intracellular protein transport relationship: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport [Term] id: GO:0042998 name: positive regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "activation of Golgi to plasma membrane protein transport" NARROW [] synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW [] synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0090316 ! positive regulation of intracellular protein transport relationship: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport [Term] id: GO:0042999 name: regulation of Golgi to plasma membrane CFTR protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport relationship: regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport [Term] id: GO:0043000 name: Golgi to plasma membrane CFTR protein transport namespace: biological_process def: "The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] synonym: "Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport" EXACT [] is_a: GO:0043001 ! Golgi to plasma membrane protein transport [Term] id: GO:0043001 name: Golgi to plasma membrane protein transport namespace: biological_process def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0006893 ! Golgi to plasma membrane transport [Term] id: GO:0043002 name: negative regulation of Golgi to plasma membrane CFTR protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] synonym: "down regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "down-regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "downregulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "inhibition of Golgi to plasma membrane CFTR protein transport" NARROW [] is_a: GO:0042997 ! negative regulation of Golgi to plasma membrane protein transport is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport relationship: negatively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport [Term] id: GO:0043003 name: positive regulation of Golgi to plasma membrane CFTR protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] synonym: "activation of Golgi to plasma membrane CFTR protein transport" NARROW [] synonym: "stimulation of Golgi to plasma membrane CFTR protein transport" NARROW [] synonym: "up regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "up-regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "upregulation of Golgi to plasma membrane CFTR protein transport" EXACT [] is_a: GO:0042998 ! positive regulation of Golgi to plasma membrane protein transport is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport relationship: positively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport [Term] id: GO:0043004 name: cytoplasmic sequestering of CFTR protein namespace: biological_process def: "The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane." [GOC:jl] synonym: "cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT [] synonym: "cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein" EXACT [] synonym: "cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)" EXACT [] synonym: "cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT [] synonym: "maintenance of CFTR protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] synonym: "retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT [] synonym: "sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT [] synonym: "sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT [] synonym: "storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT [] is_a: GO:0043002 ! negative regulation of Golgi to plasma membrane CFTR protein transport is_a: GO:0051220 ! cytoplasmic sequestering of protein [Term] id: GO:0043005 name: neuron projection namespace: cellular_component def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_pir synonym: "neurite" NARROW [] synonym: "neuron process" EXACT [] synonym: "neuron protrusion" EXACT [] synonym: "neuronal cell projection" EXACT [] xref: NIF_Subcellular:sao-867568886 is_a: GO:0042995 ! cell projection [Term] id: GO:0043006 name: activation of phospholipase A2 activity by calcium-mediated signaling namespace: biological_process def: "A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal." [GOC:dph, GOC:jl, GOC:tb] synonym: "activation of phospholipase A2 activity by calcium-mediated signalling" EXACT [GOC:mah] synonym: "calcium-dependent activation of phospholipase A2" EXACT [GOC:dph, GOC:tb] synonym: "calcium-dependent phospholipase A2 activation" EXACT [GOC:dph, GOC:tb] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0032431 ! activation of phospholipase A2 activity [Term] id: GO:0043007 name: maintenance of rDNA namespace: biological_process def: "Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010] synonym: "rDNA maintenance" EXACT [] synonym: "ribosomal DNA maintenance" EXACT [] is_a: GO:0043570 ! maintenance of DNA repeat elements [Term] id: GO:0043008 name: ATP-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP." [GOC:jl] is_a: GO:0005515 ! protein binding [Term] id: GO:0043009 name: chordate embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0043010 name: camera-type eye development namespace: biological_process alt_id: GO:0001747 alt_id: GO:0031075 def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001654 ! eye development [Term] id: GO:0043011 name: myeloid dendritic cell differentiation namespace: biological_process def: "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [CL:0000782, GOC:jl] synonym: "Langerhans cell differentiation" EXACT [] xref: Wikipedia:Dendritic_cell is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0043012 name: regulation of fusion of sperm to egg plasma membrane namespace: biological_process def: "Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] synonym: "regulation of sperm-oocyte fusion" NARROW [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0007342 ! fusion of sperm to egg plasma membrane [Term] id: GO:0043013 name: negative regulation of fusion of sperm to egg plasma membrane namespace: biological_process def: "Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] synonym: "down regulation of fusion of sperm to egg plasma membrane" EXACT [] synonym: "down-regulation of fusion of sperm to egg plasma membrane" EXACT [] synonym: "downregulation of fusion of sperm to egg plasma membrane" EXACT [] synonym: "inhibition of fusion of sperm to egg plasma membrane" NARROW [] synonym: "inhibition of sperm-oocyte fusion" NARROW [] synonym: "negative regulation of sperm-oocyte fusion" NARROW [] is_a: GO:0043012 ! regulation of fusion of sperm to egg plasma membrane is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0007342 ! fusion of sperm to egg plasma membrane [Term] id: GO:0043014 name: alpha-tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin." [GOC:jl] synonym: "alpha tubulin binding" EXACT [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0043015 name: gamma-tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin." [GOC:jl] synonym: "gamma tubulin binding" EXACT [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0043016 name: regulation of lymphotoxin A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] synonym: "regulation of LTA biosynthesis" EXACT [] synonym: "regulation of LTA biosynthetic process" EXACT [] synonym: "regulation of lymphotoxin A anabolism" EXACT [] synonym: "regulation of lymphotoxin A biosynthesis" EXACT [] synonym: "regulation of lymphotoxin A formation" EXACT [] synonym: "regulation of lymphotoxin A synthesis" EXACT [] synonym: "regulation of lymphotoxin-alpha biosynthesis" EXACT [] synonym: "regulation of lymphotoxin-alpha biosynthetic process" EXACT [] synonym: "regulation of TNF-B biosynthesis" EXACT [] synonym: "regulation of TNF-B biosynthetic process" EXACT [] synonym: "regulation of TNF-beta biosynthesis" EXACT [] synonym: "regulation of TNF-beta biosynthetic process" EXACT [] synonym: "regulation of tumor necrosis factor-beta biosynthesis" EXACT [] synonym: "regulation of tumor necrosis factor-beta biosynthetic process" EXACT [] is_a: GO:0032681 ! regulation of lymphotoxin A production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042109 ! lymphotoxin A biosynthetic process [Term] id: GO:0043017 name: positive regulation of lymphotoxin A biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] synonym: "activation of lymphotoxin A biosynthetic process" NARROW [] synonym: "positive regulation of LTA biosynthesis" EXACT [] synonym: "positive regulation of LTA biosynthetic process" EXACT [] synonym: "positive regulation of lymphotoxin A anabolism" EXACT [] synonym: "positive regulation of lymphotoxin A biosynthesis" EXACT [] synonym: "positive regulation of lymphotoxin A formation" EXACT [] synonym: "positive regulation of lymphotoxin A synthesis" EXACT [] synonym: "positive regulation of lymphotoxin-alpha biosynthesis" EXACT [] synonym: "positive regulation of lymphotoxin-alpha biosynthetic process" EXACT [] synonym: "positive regulation of TNF-B biosynthesis" EXACT [] synonym: "positive regulation of TNF-B biosynthetic process" EXACT [] synonym: "positive regulation of TNF-beta biosynthesis" EXACT [] synonym: "positive regulation of TNF-beta biosynthetic process" EXACT [] synonym: "positive regulation of tumor necrosis factor-beta biosynthesis" EXACT [] synonym: "positive regulation of tumor necrosis factor-beta biosynthetic process" EXACT [] synonym: "stimulation of lymphotoxin A biosynthetic process" NARROW [] synonym: "up regulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "up-regulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "upregulation of lymphotoxin A biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process relationship: positively_regulates GO:0042109 ! lymphotoxin A biosynthetic process [Term] id: GO:0043018 name: negative regulation of lymphotoxin A biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] synonym: "down regulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "down-regulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "downregulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "inhibition of lymphotoxin A biosynthetic process" NARROW [] synonym: "negative regulation of LTA biosynthesis" EXACT [] synonym: "negative regulation of LTA biosynthetic process" EXACT [] synonym: "negative regulation of lymphotoxin A anabolism" EXACT [] synonym: "negative regulation of lymphotoxin A biosynthesis" EXACT [] synonym: "negative regulation of lymphotoxin A formation" EXACT [] synonym: "negative regulation of lymphotoxin A synthesis" EXACT [] synonym: "negative regulation of lymphotoxin-alpha biosynthesis" EXACT [] synonym: "negative regulation of lymphotoxin-alpha biosynthetic process" EXACT [] synonym: "negative regulation of TNF-B biosynthesis" EXACT [] synonym: "negative regulation of TNF-B biosynthetic process" EXACT [] synonym: "negative regulation of TNF-beta biosynthesis" EXACT [] synonym: "negative regulation of TNF-beta biosynthetic process" EXACT [] synonym: "negative regulation of tumor necrosis factor-beta biosynthesis" EXACT [] synonym: "negative regulation of tumor necrosis factor-beta biosynthetic process" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process relationship: negatively_regulates GO:0042109 ! lymphotoxin A biosynthetic process [Term] id: GO:0043020 name: NADPH oxidase complex namespace: cellular_component def: "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767] synonym: "flavocytochrome b558" NARROW [] synonym: "respiratory-burst oxidase" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0043021 name: ribonucleoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any complex of RNA and protein." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "RNP binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0043022 name: ribosome binding namespace: molecular_function alt_id: GO:0030376 def: "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] subset: gosubset_prok synonym: "ribosome receptor activity" NARROW [] is_a: GO:0043021 ! ribonucleoprotein binding [Term] id: GO:0043023 name: ribosomal large subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of the larger ribosomal subunit." [GOC:go_curators] subset: gosubset_prok is_a: GO:0043021 ! ribonucleoprotein binding [Term] id: GO:0043024 name: ribosomal small subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of the small ribosomal subunit." [GOC:go_curators] subset: gosubset_prok is_a: GO:0043021 ! ribonucleoprotein binding [Term] id: GO:0043025 name: neuronal cell body namespace: cellular_component def: "The portion of a neuron that includes the nucleus, but excludes all cell projections such as axons and dendrites." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. subset: goslim_pir synonym: "neuron cell body" EXACT [] synonym: "neuronal cell soma" EXACT [] xref: NIF_Subcellular:sao1044911821 xref: Wikipedia:Soma_(biology) is_a: GO:0044297 ! cell body [Term] id: GO:0043027 name: caspase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl, PMID:14744432, Wikipedia:Caspase] is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity is_a: GO:0043028 ! caspase regulator activity [Term] id: GO:0043028 name: caspase regulator activity namespace: molecular_function def: "Modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl, PMID:14744432, Wikipedia:Caspase] xref: Reactome:139818 "caspase regulator activity" is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0043029 name: T cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "T lymphocyte homeostasis" EXACT [] synonym: "T-cell homeostasis" EXACT [] synonym: "T-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0043030 name: regulation of macrophage activation namespace: biological_process def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl] is_a: GO:0002694 ! regulation of leukocyte activation relationship: regulates GO:0042116 ! macrophage activation [Term] id: GO:0043031 name: negative regulation of macrophage activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl] synonym: "down regulation of macrophage activation" EXACT [] synonym: "down-regulation of macrophage activation" EXACT [] synonym: "downregulation of macrophage activation" EXACT [] synonym: "inhibition of macrophage activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation relationship: negatively_regulates GO:0042116 ! macrophage activation [Term] id: GO:0043032 name: positive regulation of macrophage activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl] synonym: "activation of macrophage activation" NARROW [] synonym: "stimulation of macrophage activation" NARROW [] synonym: "up regulation of macrophage activation" EXACT [] synonym: "up-regulation of macrophage activation" EXACT [] synonym: "upregulation of macrophage activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation relationship: positively_regulates GO:0042116 ! macrophage activation [Term] id: GO:0043033 name: isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591] subset: goslim_pir subset: gosubset_prok synonym: "debranching enzyme complex" BROAD [] is_a: GO:0043234 ! protein complex [Term] id: GO:0043034 name: costamere namespace: cellular_component def: "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:6405378] xref: Wikipedia:Costamere is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030016 ! myofibril [Term] id: GO:0043035 name: chromatin insulator sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795] is_a: GO:0031490 ! chromatin DNA binding [Term] id: GO:0043036 name: starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] synonym: "starch granule" EXACT [] is_a: GO:0044435 ! plastid part [Term] id: GO:0043038 name: amino acid activation namespace: biological_process def: "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl] subset: gosubset_prok is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0043039 name: tRNA aminoacylation namespace: biological_process def: "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs] subset: gosubset_prok synonym: "aminoacyl-tRNA biosynthesis" EXACT [GOC:mah] synonym: "aminoacyl-tRNA biosynthetic process" EXACT [GOC:mah] synonym: "tRNA charging" EXACT [] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0043038 ! amino acid activation [Term] id: GO:0043040 name: tRNA aminoacylation for nonribosomal peptide biosynthetic process namespace: biological_process def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis." [GOC:jl] subset: gosubset_prok synonym: "tRNA aminoacylation for nonribosomal peptide anabolism" EXACT [] synonym: "tRNA aminoacylation for nonribosomal peptide biosynthesis" EXACT [] synonym: "tRNA aminoacylation for nonribosomal peptide formation" EXACT [] synonym: "tRNA aminoacylation for nonribosomal peptide synthesis" EXACT [] is_a: GO:0043039 ! tRNA aminoacylation is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process [Term] id: GO:0043041 name: amino acid activation for nonribosomal peptide biosynthetic process namespace: biological_process def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl] subset: gosubset_prok synonym: "nonribosomal amino acid activation" RELATED [] is_a: GO:0043038 ! amino acid activation relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process [Term] id: GO:0043042 name: amino acid adenylylation by nonribosomal peptide synthase namespace: biological_process def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910] subset: gosubset_prok synonym: "amino acid adenylation by nonribosomal peptide synthase" EXACT [] synonym: "amino acid adenylation by NRPS" EXACT [] is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process [Term] id: GO:0043043 name: peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [CHEBI:16670, GOC:dph, GOC:jl] subset: gosubset_prok synonym: "peptide anabolism" EXACT [] synonym: "peptide biosynthesis" EXACT [] synonym: "peptide formation" EXACT [] synonym: "peptide synthesis" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0043044 name: ATP-dependent chromatin remodeling namespace: biological_process def: "Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764] synonym: "ATP-dependent chromatin remodelling" EXACT [] is_a: GO:0006338 ! chromatin remodeling [Term] id: GO:0043045 name: DNA methylation involved in embryo development namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression." [GOC:go_curators, PMID:12138111] synonym: "de novo DNA methylation" RELATED [] is_a: GO:0006306 ! DNA methylation relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0043046 name: DNA methylation involved in gamete generation namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete." [GOC:go_curators, PMID:12138111] synonym: "de novo DNA methylation" RELATED [] is_a: GO:0006306 ! DNA methylation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0043047 name: single-stranded telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] synonym: "telomeric ssDNA binding" EXACT [GOC:mah] is_a: GO:0003697 ! single-stranded DNA binding is_a: GO:0042162 ! telomeric DNA binding [Term] id: GO:0043048 name: dolichyl monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative." [GOC:jl] subset: gosubset_prok synonym: "dolichyl monophosphate anabolism" EXACT [] synonym: "dolichyl monophosphate biosynthesis" EXACT [] synonym: "dolichyl monophosphate formation" EXACT [] synonym: "dolichyl monophosphate synthesis" EXACT [] is_a: GO:0019408 ! dolichol biosynthetic process [Term] id: GO:0043049 name: otic placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." [GOC:go_curators, PMID:12668634] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0030916 ! otic vesicle formation [Term] id: GO:0043050 name: pharyngeal pumping namespace: biological_process def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes." [GOC:cab1, PMID:2181052] synonym: "pumping behavior" RELATED [] is_a: GO:0042755 ! eating behavior [Term] id: GO:0043051 name: regulation of pharyngeal pumping namespace: biological_process def: "Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes." [GOC:cab1, PMID:2181052] is_a: GO:0060259 ! regulation of feeding behavior relationship: regulates GO:0043050 ! pharyngeal pumping [Term] id: GO:0043052 name: thermotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] synonym: "taxis in response to temperature stimulus" EXACT [] xref: Wikipedia:Thermotaxis is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0042330 ! taxis [Term] id: GO:0043053 name: dauer entry namespace: biological_process def: "Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:10077613] synonym: "nematode entry into dormancy" EXACT [] is_a: GO:0055115 ! entry into diapause relationship: part_of GO:0040024 ! dauer larval development [Term] id: GO:0043054 name: dauer exit namespace: biological_process def: "Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:12620986] synonym: "exit from nematode dormancy" EXACT [] is_a: GO:0071981 ! exit from diapause relationship: part_of GO:0040024 ! dauer larval development [Term] id: GO:0043055 name: maintenance of dauer namespace: biological_process def: "Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, WB_REF:wm2003ab740] synonym: "maintenance of dormancy in the nematode" EXACT [] is_a: GO:0071982 ! maintenance of diapause relationship: part_of GO:0040024 ! dauer larval development [Term] id: GO:0043056 name: forward locomotion namespace: biological_process def: "Anterior movement of an organism, following the direction of the head of the animal." [GOC:go_curators] is_a: GO:0033058 ! directional locomotion [Term] id: GO:0043057 name: backward locomotion namespace: biological_process def: "Posterior movement of an organism, e.g. following the direction of the tail of an animal." [GOC:go_curators] is_a: GO:0033058 ! directional locomotion [Term] id: GO:0043058 name: regulation of backward locomotion namespace: biological_process def: "Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism." [GOC:go_curators] is_a: GO:0040012 ! regulation of locomotion relationship: regulates GO:0043057 ! backward locomotion [Term] id: GO:0043059 name: regulation of forward locomotion namespace: biological_process def: "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators] is_a: GO:0040012 ! regulation of locomotion relationship: regulates GO:0043056 ! forward locomotion [Term] id: GO:0043060 name: meiotic metaphase I plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666] is_a: GO:0051311 ! meiotic metaphase plate congression relationship: part_of GO:0045143 ! homologous chromosome segregation [Term] id: GO:0043061 name: meiotic metaphase II plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666] is_a: GO:0051311 ! meiotic metaphase plate congression relationship: part_of GO:0045144 ! meiotic sister chromatid segregation [Term] id: GO:0043062 name: extracellular structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "extracellular structure organisation" EXACT [GOC:curators] synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0043063 name: intercellular bridge organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid] synonym: "intercellular bridge organisation" EXACT [GOC:curators] synonym: "intercellular bridge organization and biogenesis" RELATED [GOC:mah] is_a: GO:0043062 ! extracellular structure organization [Term] id: GO:0043064 name: flagellum organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement." [GOC:curators, ISBN:0815316194] subset: gosubset_prok synonym: "flagellum organisation" EXACT [GOC:curators] synonym: "flagellum organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030030 ! cell projection organization [Term] id: GO:0043065 name: positive regulation of apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptosis." [GOC:jl] synonym: "activation of apoptosis" NARROW [] synonym: "stimulation of apoptosis" NARROW [] synonym: "up regulation of apoptosis" EXACT [] synonym: "up-regulation of apoptosis" EXACT [] synonym: "upregulation of apoptosis" EXACT [] is_a: GO:0042981 ! regulation of apoptosis is_a: GO:0043068 ! positive regulation of programmed cell death relationship: positively_regulates GO:0006915 ! apoptosis [Term] id: GO:0043066 name: negative regulation of apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptosis." [GOC:jl] synonym: "down regulation of apoptosis" EXACT [] synonym: "down-regulation of apoptosis" EXACT [] synonym: "downregulation of apoptosis" EXACT [] synonym: "inhibition of apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptosis is_a: GO:0043069 ! negative regulation of programmed cell death relationship: negatively_regulates GO:0006915 ! apoptosis [Term] id: GO:0043067 name: regulation of programmed cell death namespace: biological_process alt_id: GO:0043070 def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0010941 ! regulation of cell death relationship: regulates GO:0012501 ! programmed cell death [Term] id: GO:0043068 name: positive regulation of programmed cell death namespace: biological_process alt_id: GO:0043071 def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "activation of programmed cell death" NARROW [] synonym: "positive regulation of non-apoptotic programmed cell death" NARROW [] synonym: "stimulation of programmed cell death" NARROW [] synonym: "up regulation of programmed cell death" EXACT [] synonym: "up-regulation of programmed cell death" EXACT [] synonym: "upregulation of programmed cell death" EXACT [] is_a: GO:0010942 ! positive regulation of cell death is_a: GO:0043067 ! regulation of programmed cell death relationship: positively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0043069 name: negative regulation of programmed cell death namespace: biological_process alt_id: GO:0043072 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "down regulation of programmed cell death" EXACT [] synonym: "down-regulation of programmed cell death" EXACT [] synonym: "downregulation of programmed cell death" EXACT [] synonym: "inhibition of programmed cell death" NARROW [] synonym: "negative regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0060548 ! negative regulation of cell death relationship: negatively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0043073 name: germ cell nucleus namespace: cellular_component def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators] synonym: "germ-cell nucleus" EXACT [] is_a: GO:0005634 ! nucleus [Term] id: GO:0043075 name: sperm cell nucleus (sensu Magnoliophyta) namespace: cellular_component def: "OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents." [GOC:jl] comment: This term was made obsolete because the definition was incorrect. synonym: "pollen germ cell nucleus" EXACT [] synonym: "pollen germ-cell nucleus" EXACT [] is_obsolete: true consider: GO:0048555 [Term] id: GO:0043076 name: megasporocyte nucleus namespace: cellular_component def: "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153] synonym: "megaspore mother cell nucleus" EXACT [] is_a: GO:0005634 ! nucleus [Term] id: GO:0043077 name: initiation of acetate catabolic process namespace: biological_process def: "The activation of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:jl] subset: gosubset_prok synonym: "initiation of acetate breakdown" EXACT [] synonym: "initiation of acetate catabolism" EXACT [] synonym: "initiation of acetate degradation" EXACT [] is_a: GO:0045754 ! positive regulation of acetate catabolic process [Term] id: GO:0043078 name: polar nucleus namespace: cellular_component def: "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153] is_a: GO:0043076 ! megasporocyte nucleus [Term] id: GO:0043079 name: antipodal cell nucleus namespace: cellular_component def: "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [CL:0000537, GOC:jl] is_a: GO:0043076 ! megasporocyte nucleus [Term] id: GO:0043082 name: megagametophyte egg cell nucleus namespace: cellular_component def: "The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo." [GOC:jl, GOC:mtg_sensu] is_a: GO:0043076 ! megasporocyte nucleus [Term] id: GO:0043083 name: synaptic cleft namespace: cellular_component def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm] xref: NIF_Subcellular:sao243541954 is_a: GO:0044420 ! extracellular matrix part is_a: GO:0044456 ! synapse part [Term] id: GO:0043084 name: penile erection namespace: biological_process def: "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:jl, Wikipedia:Penile_erection] xref: Wikipedia:Erection#Penile_erection is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007620 ! copulation [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process def: "Any process that activates or increases the activity of an enzyme." [GOC:jl, GOC:tb] subset: gosubset_prok synonym: "activation of enzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "stimulation of enzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "upregulation of enzyme activity" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0043086 name: negative regulation of catalytic activity namespace: biological_process def: "Any process that stops or reduces the activity of an enzyme." [GOC:jl, GOC:tb] subset: gosubset_prok synonym: "down regulation of enzyme activity" EXACT [] synonym: "down-regulation of enzyme activity" EXACT [] synonym: "downregulation of enzyme activity" EXACT [] synonym: "inhibition of enzyme activity" NARROW [] synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0043087 name: regulation of GTPase activity namespace: biological_process def: "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl] subset: gosubset_prok is_a: GO:0033124 ! regulation of GTP catabolic process is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0043088 name: regulation of Cdc42 GTPase activity namespace: biological_process def: "Any process that modulates the activity of the GTPase Cdc42." [GOC:jl] is_a: GO:0032319 ! regulation of Rho GTPase activity relationship: part_of GO:0032489 ! regulation of Cdc42 protein signal transduction [Term] id: GO:0043089 name: positive regulation of Cdc42 GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of the GTPase Cdc42." [GOC:jl] synonym: "stimulation of Cdc42 GTPase activity" NARROW [] synonym: "up regulation of Cdc42 GTPase activity" EXACT [] synonym: "up-regulation of Cdc42 GTPase activity" EXACT [] synonym: "upregulation of Cdc42 GTPase activity" EXACT [] is_a: GO:0032321 ! positive regulation of Rho GTPase activity is_a: GO:0043088 ! regulation of Cdc42 GTPase activity [Term] id: GO:0043090 name: amino acid import namespace: biological_process def: "The directed movement of amino acids into a cell or organelle." [GOC:jl] subset: gosubset_prok synonym: "amino acid uptake" EXACT [] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0043091 name: L-arginine import namespace: biological_process def: "The directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah] synonym: "L-arginine uptake" EXACT [] is_a: GO:0015809 ! arginine transport is_a: GO:0043092 ! L-amino acid import [Term] id: GO:0043092 name: L-amino acid import namespace: biological_process def: "The directed movement of L-enantiomer amino acids into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-amino acid uptake" EXACT [] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0043090 ! amino acid import [Term] id: GO:0043093 name: cytokinesis by binary fission namespace: biological_process def: "A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells; the process in which prokaryotic cells divide." [GOC:mah, ISBN:0815108893, PMID:12626683] comment: Note that this term is intended for the annotation of prokaryotic gene products. subset: gosubset_prok synonym: "prokaryote-type cytokinesis" EXACT [GOC:mah] synonym: "prokaryotic fission" EXACT [Wikipedia:Binary_fission] xref: Wikipedia:Binary_fission is_a: GO:0000910 ! cytokinesis is_a: GO:0019954 ! asexual reproduction is_a: GO:0032505 ! reproduction of a single-celled organism [Term] id: GO:0043094 name: cellular metabolic compound salvage namespace: biological_process def: "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells." [GOC:mlg] subset: goslim_pir subset: gosubset_prok is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0043095 name: regulation of GTP cyclohydrolase I activity namespace: biological_process def: "Any process that modulates the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] subset: gosubset_prok is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0043096 name: purine base salvage namespace: biological_process def: "Any process that generates purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "purine nucleobase salvage" EXACT [CHEBI:26386] is_a: GO:0009113 ! purine base biosynthetic process is_a: GO:0043101 ! purine-containing compound salvage [Term] id: GO:0043097 name: pyrimidine nucleoside salvage namespace: biological_process def: "Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok xref: Reactome:1252993 "Pyrimidine salvage reactions" xref: Reactome:1279923 "Pyrimidine salvage reactions" xref: Reactome:1298818 "Pyrimidine salvage reactions" xref: Reactome:1326497 "Pyrimidine salvage reactions" xref: Reactome:1352604 "Pyrimidine salvage reactions" xref: Reactome:1372836 "Pyrimidine salvage reactions" xref: Reactome:1392848 "Pyrimidine salvage reactions" xref: Reactome:1417323 "Pyrimidine salvage reactions" xref: Reactome:1450410 "Pyrimidine salvage reactions" xref: Reactome:1470941 "Pyrimidine salvage reactions" xref: Reactome:1482981 "Pyrimidine salvage reactions" xref: Reactome:1496753 "Pyrimidine salvage reactions" xref: Reactome:1514143 "Pyrimidine salvage reactions" xref: Reactome:1520969 "Pyrimidine salvage reactions" xref: Reactome:1526720 "Pyrimidine salvage reactions" xref: Reactome:1532444 "Pyrimidine salvage reactions" xref: Reactome:1538027 "Pyrimidine salvage reactions" xref: Reactome:1539249 "Pyrimidine salvage reactions" xref: Reactome:1540300 "Pyrimidine salvage reactions" xref: Reactome:73614 "Pyrimidine salvage reactions" is_a: GO:0008655 ! pyrimidine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process [Term] id: GO:0043098 name: purine deoxyribonucleoside salvage namespace: biological_process def: "Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process [Term] id: GO:0043099 name: pyrimidine deoxyribonucleoside salvage namespace: biological_process def: "Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043097 ! pyrimidine nucleoside salvage is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process [Term] id: GO:0043100 name: pyrimidine base salvage namespace: biological_process def: "Any process that generates pyrimidine bases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "pyrimidine nucleobase salvage" EXACT [CHEBI:26432] is_a: GO:0008655 ! pyrimidine-containing compound salvage [Term] id: GO:0043101 name: purine-containing compound salvage namespace: biological_process def: "Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis." [CHEBI:26401, GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "purine salvage" RELATED [GOC:curators] xref: Reactome:1253016 "Purine salvage" xref: Reactome:1279945 "Purine salvage" xref: Reactome:1298837 "Purine salvage" xref: Reactome:1326521 "Purine salvage" xref: Reactome:1352629 "Purine salvage" xref: Reactome:1372855 "Purine salvage" xref: Reactome:1392868 "Purine salvage" xref: Reactome:1417345 "Purine salvage" xref: Reactome:1450437 "Purine salvage" xref: Reactome:1470962 "Purine salvage" xref: Reactome:1482998 "Purine salvage" xref: Reactome:1496772 "Purine salvage" xref: Reactome:1514162 "Purine salvage" xref: Reactome:1520986 "Purine salvage" xref: Reactome:1526740 "Purine salvage" xref: Reactome:1532464 "Purine salvage" xref: Reactome:1536004 "Purine salvage" xref: Reactome:1538004 "Purine salvage" xref: Reactome:1539258 "Purine salvage" xref: Reactome:1540310 "Purine salvage" xref: Reactome:74217 "Purine salvage" is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0043102 name: amino acid salvage namespace: biological_process def: "Any process which produces an amino acid from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0043103 name: hypoxanthine salvage namespace: biological_process def: "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "adenine, hypoxanthine and their nucleoside salvage" NARROW [] synonym: "guanine, xanthine and their nucleoside salvage" NARROW [] is_a: GO:0043096 ! purine base salvage is_a: GO:0046101 ! hypoxanthine biosynthetic process [Term] id: GO:0043104 name: positive regulation of GTP cyclohydrolase I activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] subset: gosubset_prok synonym: "activation of GTP cyclohydrolase I activity" NARROW [] synonym: "stimulation of GTP cyclohydrolase I activity" NARROW [] synonym: "up regulation of GTP cyclohydrolase I activity" EXACT [] synonym: "up-regulation of GTP cyclohydrolase I activity" EXACT [] synonym: "upregulation of GTP cyclohydrolase I activity" EXACT [] is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0043105 name: negative regulation of GTP cyclohydrolase I activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] subset: gosubset_prok synonym: "down regulation of GTP cyclohydrolase I activity" EXACT [] synonym: "down-regulation of GTP cyclohydrolase I activity" EXACT [] synonym: "downregulation of GTP cyclohydrolase I activity" EXACT [] synonym: "inhibition of GTP cyclohydrolase I activity" NARROW [] is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0043106 name: GTP cyclohydrolase I binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme GTP cyclohydrolase I." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0043107 name: type IV pilus-dependent motility namespace: biological_process def: "Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility." [GOC:go_curators, PMID:12704238] subset: gosubset_prok synonym: "social gliding motility" NARROW [] synonym: "TFP-dependent motility" EXACT [] synonym: "TFP-dependent movement" EXACT [] synonym: "twitching motility" NARROW [] synonym: "type 4 pilus-dependent motility" EXACT [] synonym: "type four pilus-dependent motility" EXACT [] is_a: GO:0048870 ! cell motility [Term] id: GO:0043108 name: pilus retraction namespace: biological_process def: "The process of withdrawing a pilus back into a cell." [GOC:go_curators] subset: gosubset_prok is_a: GO:0043711 ! pilus organization [Term] id: GO:0043110 name: rDNA spacer replication fork barrier binding namespace: molecular_function def: "Interacting selectively and non-covalently with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [GOC:jl, GOC:mah, PMID:14645529] synonym: "RFB binding" EXACT [] synonym: "RTS1 barrier binding" EXACT [] synonym: "RTS1 element binding" EXACT [] is_a: GO:0000182 ! rDNA binding is_a: GO:0031634 ! replication fork barrier binding [Term] id: GO:0043111 name: replication fork arrest namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork." [GOC:jl, PMID:14645529] comment: See also the biological process term 'site-specific replication termination ; GO:0071170' and its children. subset: gosubset_prok synonym: "negative regulation of DNA replication at replication fork barrier" EXACT [GOC:dph, GOC:tb] synonym: "replication fork blocking" EXACT [] synonym: "replication fork stalling" EXACT [] is_a: GO:0045005 ! maintenance of fidelity involved in DNA-dependent DNA replication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication [Term] id: GO:0043112 name: receptor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:jl] subset: gosubset_prok synonym: "receptor metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0043113 name: receptor clustering namespace: biological_process def: "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf] is_a: GO:0043112 ! receptor metabolic process relationship: part_of GO:0007172 ! signal complex assembly [Term] id: GO:0043114 name: regulation of vascular permeability namespace: biological_process def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid." [GOC:jl] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0043115 name: precorrin-2 dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin." [EC:1.3.1.76, RHEA:15616] subset: gosubset_prok synonym: "1,3-dimethyluroporphyrinogen III dehydrogenase activity" EXACT [] synonym: "CysG" RELATED [EC:1.3.1.76] synonym: "dihydrosirohydrochlorin dehydrogenase activity" EXACT [] synonym: "Met8p" RELATED [EC:1.3.1.76] synonym: "precorrin-2 oxidase activity" EXACT [EC:1.3.1.76] synonym: "precorrin-2:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.76] synonym: "SirC" RELATED [EC:1.3.1.76] synonym: "siroheme synthase activity" BROAD [] xref: EC:1.3.1.76 xref: KEGG:R03947 xref: MetaCyc:DIMETHUROPORDEHYDROG-RXN xref: RHEA:15616 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0043116 name: negative regulation of vascular permeability namespace: biological_process def: "Any process that reduces the extent to which blood vessels can be pervaded by fluid." [GOC:jl] synonym: "down regulation of vascular permeability" EXACT [] synonym: "down-regulation of vascular permeability" EXACT [] synonym: "downregulation of vascular permeability" EXACT [] synonym: "inhibition of vascular permeability" NARROW [] is_a: GO:0043114 ! regulation of vascular permeability [Term] id: GO:0043117 name: positive regulation of vascular permeability namespace: biological_process def: "Any process that increases the extent to which blood vessels can be pervaded by fluid." [GOC:jl] synonym: "activation of vascular permeability" NARROW [] synonym: "stimulation of vascular permeability" NARROW [] synonym: "up regulation of vascular permeability" EXACT [] synonym: "up-regulation of vascular permeability" EXACT [] synonym: "upregulation of vascular permeability" EXACT [] is_a: GO:0043114 ! regulation of vascular permeability [Term] id: GO:0043120 name: tumor necrosis factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages." [GOC:jl, http://lookwayup.com/] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0043121 name: neurotrophin binding namespace: molecular_function def: "Interacting selectively and non-covalently with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth." [GOC:jl, http://www.mercksource.com/] synonym: "neurotrophin TRK receptor activity" RELATED [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0043122 name: regulation of I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade." [GOC:jl, PMID:12773372] is_a: GO:0010627 ! regulation of intracellular protein kinase cascade relationship: regulates GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0043123 name: positive regulation of I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GOC:jl] synonym: "activation of I-kappaB kinase/NF-kappaB cascade" NARROW [] synonym: "stimulation of I-kappaB kinase/NF-kappaB cascade" NARROW [] synonym: "up regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "up-regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "upregulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] xref: Reactome:937039 "IRAK1 recruits IKK comlex" is_a: GO:0010740 ! positive regulation of intracellular protein kinase cascade is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB cascade relationship: positively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0043124 name: negative regulation of I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GOC:jl] synonym: "down regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "down-regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "downregulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "inhibition of I-kappaB kinase/NF-kappaB cascade" NARROW [] is_a: GO:0010741 ! negative regulation of intracellular protein kinase cascade is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB cascade relationship: negatively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0043125 name: ErbB-3 class receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3." [GOC:jl] synonym: "HER3 receptor binding" EXACT [] synonym: "Neu/ErbB-2 receptor activity" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0043126 name: regulation of 1-phosphatidylinositol 4-kinase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl] subset: gosubset_prok synonym: "regulation of PI4K activity" EXACT [] is_a: GO:0043550 ! regulation of lipid kinase activity [Term] id: GO:0043127 name: negative regulation of 1-phosphatidylinositol 4-kinase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl] subset: gosubset_prok synonym: "down regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "down-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "downregulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "inhibition of 1-phosphatidylinositol 4-kinase activity" NARROW [] synonym: "negative regulation of PI4K activity" EXACT [] is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity is_a: GO:0090219 ! negative regulation of lipid kinase activity [Term] id: GO:0043128 name: positive regulation of 1-phosphatidylinositol 4-kinase activity namespace: biological_process def: "Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase." [GOC:jl] subset: gosubset_prok synonym: "activation of 1-phosphatidylinositol 4-kinase activity" NARROW [] synonym: "positive regulation of PI4K activity" EXACT [] synonym: "stimulation of 1-phosphatidylinositol 4-kinase activity" NARROW [] synonym: "up regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "up-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "upregulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity is_a: GO:0090218 ! positive regulation of lipid kinase activity [Term] id: GO:0043129 name: surfactant homeostasis namespace: biological_process def: "Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli." [PMID:9751757] is_a: GO:0048875 ! chemical homeostasis within a tissue [Term] id: GO:0043130 name: ubiquitin binding namespace: molecular_function def: "Interacting selectively and non-covalently and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] xref: Reactome:160991 "ubiquitin binding" is_a: GO:0032182 ! small conjugating protein binding [Term] id: GO:0043131 name: enucleation namespace: biological_process def: "The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation." [GOC:hgd] is_a: GO:0071845 ! cellular component disassembly at cellular level relationship: part_of GO:0043354 ! enucleate erythrocyte maturation [Term] id: GO:0043132 name: NAD transport namespace: biological_process def: "The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl] synonym: "NAD (oxidized) transport" EXACT [] synonym: "NAD (reduced) transport" EXACT [] synonym: "NADH transport" EXACT [] synonym: "nicotinamide adenine dinucleotide transport" EXACT [] synonym: "oxidized NAD transport" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide transport" EXACT [] synonym: "reduced NAD transport" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide transport" EXACT [] is_a: GO:0051181 ! cofactor transport [Term] id: GO:0043133 name: hindgut contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046] is_a: GO:0006939 ! smooth muscle contraction is_a: GO:0022600 ! digestive system process [Term] id: GO:0043134 name: regulation of hindgut contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0044058 ! regulation of digestive system process relationship: regulates GO:0043133 ! hindgut contraction [Term] id: GO:0043135 name: 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+." [MetaCyc:RXN-10969, PMID:12370170] synonym: "PRPP pyrophosphatase activity" EXACT [] xref: MetaCyc:RXN-10969 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0043136 name: glycerol-3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate." [GOC:jl] xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043137 name: DNA replication, removal of RNA primer namespace: biological_process def: "Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease." [GOC:jl, PMID:12424238] subset: gosubset_prok synonym: "Okazaki initiator RNA removal" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0006401 ! RNA catabolic process relationship: part_of GO:0033567 ! DNA replication, Okazaki fragment processing [Term] id: GO:0043138 name: 3'-5' DNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] synonym: "3' to 5' DNA helicase activity" EXACT [] is_a: GO:0003678 ! DNA helicase activity [Term] id: GO:0043139 name: 5'-3' DNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] synonym: "5' to 3' DNA helicase activity" EXACT [] is_a: GO:0003678 ! DNA helicase activity [Term] id: GO:0043140 name: ATP-dependent 3'-5' DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT [] is_a: GO:0004003 ! ATP-dependent DNA helicase activity is_a: GO:0043138 ! 3'-5' DNA helicase activity [Term] id: GO:0043141 name: ATP-dependent 5'-3' DNA helicase activity namespace: molecular_function alt_id: GO:0008722 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT [] synonym: "DNA helicase IV activity" NARROW [] xref: EC:3.6.1.- is_a: GO:0004003 ! ATP-dependent DNA helicase activity is_a: GO:0043139 ! 5'-3' DNA helicase activity [Term] id: GO:0043142 name: single-stranded DNA-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:go_curators] synonym: "ssDNA-dependent ATPase activity" EXACT [] is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0043143 name: regulation of translation by machinery localization namespace: biological_process def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl] subset: gosubset_prok synonym: "establishment and maintenance of translational machinery localization" EXACT [] synonym: "establishment and maintenance of translational protein localization" EXACT [] synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah] synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb] synonym: "translational protein localization" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0043144 name: snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA." [GOC:go_curators, PMID:12773397] is_a: GO:0016074 ! snoRNA metabolic process is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0043145 name: snoRNA 3'-end cleavage namespace: biological_process def: "The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional." [GOC:go_curators, PMID:12773397] synonym: "snoRNA 3' end cleavage" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0043146 name: spindle stabilization namespace: biological_process def: "Any process involved in maintaining the structure and integrity of the spindle." [GOC:go_curators] is_a: GO:0007026 ! negative regulation of microtubule depolymerization is_a: GO:0090224 ! regulation of spindle organization [Term] id: GO:0043147 name: meiotic spindle stabilization namespace: biological_process def: "The cell cycle process in which spindle integrity is maintained during M phase of meiosis." [GOC:go_curators] is_a: GO:0022402 ! cell cycle process is_a: GO:0043146 ! spindle stabilization relationship: part_of GO:0000212 ! meiotic spindle organization [Term] id: GO:0043148 name: mitotic spindle stabilization namespace: biological_process def: "The cell cycle process in which spindle integrity is maintained during M phase of mitosis." [GOC:go_curators] is_a: GO:0022402 ! cell cycle process is_a: GO:0043146 ! spindle stabilization is_a: GO:0060236 ! regulation of mitotic spindle organization [Term] id: GO:0043149 name: stress fiber assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity." [GOC:go_curators, GOC:mah, PMID:16651381] synonym: "actin cable assembly" RELATED [GOC:mah] synonym: "actin cable formation" RELATED [GOC:mah] synonym: "stress fibre biosynthesis" RELATED [] synonym: "stress fibre formation" RELATED [] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0043150 name: DNA synthesis involved in double-strand break repair via homologous recombination namespace: biological_process def: "The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination." [GOC:go_curators] subset: gosubset_prok synonym: "DNA synthesis during double-strand break repair via homologous recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0000731 ! DNA synthesis involved in DNA repair relationship: part_of GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0043151 name: DNA synthesis involved in double-strand break repair via single-strand annealing namespace: biological_process def: "The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing." [GOC:go_curators] subset: gosubset_prok synonym: "DNA synthesis during double-strand break repair via single-strand annealing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000731 ! DNA synthesis involved in DNA repair relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0043152 name: induction of bacterial agglutination namespace: biological_process def: "Any process in which infecting bacteria are clumped together by a host organism." [GOC:jl] is_a: GO:0019731 ! antibacterial humoral response [Term] id: GO:0043153 name: entrainment of circadian clock by photoperiod namespace: biological_process def: "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl] is_a: GO:0009648 ! photoperiodism is_a: GO:0009649 ! entrainment of circadian clock [Term] id: GO:0043154 name: negative regulation of caspase activity namespace: biological_process alt_id: GO:0001719 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of caspase activity." [GOC:jl] synonym: "down regulation of caspase activity" EXACT [] synonym: "down-regulation of caspase activity" EXACT [] synonym: "downregulation of caspase activity" EXACT [] synonym: "inhibition of caspase activation" NARROW [] synonym: "inhibition of caspase activity" NARROW [] synonym: "negative regulation of caspase activation" EXACT [] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:0043281 ! regulation of caspase activity [Term] id: GO:0043155 name: negative regulation of photosynthesis, light reaction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl] synonym: "down regulation of photosynthesis, light reaction" EXACT [] synonym: "down-regulation of photosynthesis, light reaction" EXACT [] synonym: "downregulation of photosynthesis, light reaction" EXACT [] synonym: "inhibition of photosynthesis, light reaction" NARROW [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0042548 ! regulation of photosynthesis, light reaction relationship: negatively_regulates GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0043156 name: chromatin remodeling in response to cation stress namespace: biological_process def: "Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, GOC:vw, PMID:14762213] is_a: GO:0006338 ! chromatin remodeling is_a: GO:0071473 ! cellular response to cation stress [Term] id: GO:0043157 name: response to cation stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, PMID:14762213] subset: gosubset_prok is_a: GO:0009651 ! response to salt stress [Term] id: GO:0043158 name: heterocyst differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen." [GOC:jl] subset: gosubset_prok synonym: "heterocyst biosynthesis" EXACT [] synonym: "heterocyst cell differentiation" EXACT [] synonym: "heterocyst formation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0043159 name: acrosomal matrix namespace: cellular_component def: "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729] is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0001669 ! acrosomal vesicle [Term] id: GO:0043160 name: acrosomal lumen namespace: cellular_component def: "The volume enclosed within the acrosome membrane." [GOC:go_curators] is_a: GO:0034774 ! secretory granule lumen is_a: GO:0043202 ! lysosomal lumen relationship: part_of GO:0001669 ! acrosomal vesicle [Term] id: GO:0043161 name: proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] synonym: "proteasomal pathway" EXACT [] synonym: "proteasomal processing" RELATED [] synonym: "proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "proteasomal ubiquitin-dependent protein degradation" EXACT [] synonym: "proteasome pathway" RELATED [] xref: Reactome:1235510 "Degradation multiubiquitinated Cyclin A" xref: Reactome:1262832 "Degradation multiubiquitinated Cyclin A" xref: Reactome:1309101 "Degradation multiubiquitinated Cyclin A" xref: Reactome:1336176 "Degradation multiubiquitinated Cyclin A" xref: Reactome:1381014 "Degradation multiubiquitinated Cyclin A" xref: Reactome:1402122 "Degradation multiubiquitinated Cyclin A" xref: Reactome:1430154 "Degradation multiubiquitinated Cyclin A" xref: Reactome:1458898 "Degradation multiubiquitinated Cyclin A" xref: Reactome:174255 "Degradation multiubiquitinated Cyclin A" is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process is_a: GO:0010498 ! proteasomal protein catabolic process [Term] id: GO:0043162 name: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343] synonym: "ubiquitin-dependent protein breakdown via the multivesicular body pathway" EXACT [] synonym: "ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "ubiquitin-dependent protein degradation via the multivesicular body pathway" EXACT [] is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process [Term] id: GO:0043163 name: cell envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "cell envelope organisation" EXACT [GOC:curators] synonym: "cell envelope organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045229 ! external encapsulating structure organization [Term] id: GO:0043164 name: Gram-negative-bacterium-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane." [GOC:jl, GOC:mtg_sensu, ISBN:0815108893] subset: gosubset_prok synonym: "1-2nm peptidoglycan-based cell wall biogenesis" EXACT [] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0043165 name: Gram-negative-bacterium-type cell outer membrane assembly namespace: biological_process def: "The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:jl, ISBN:0135712254] subset: gosubset_prok synonym: "cell outer membrane biogenesis" RELATED [GOC:mah] is_a: GO:0071709 ! membrane assembly relationship: part_of GO:0043163 ! cell envelope organization [Term] id: GO:0043167 name: ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with ions, charged atoms or groups of atoms." [GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "atom binding" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0043168 name: anion binding namespace: molecular_function def: "Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge." [GOC:jl] subset: gosubset_prok is_a: GO:0043167 ! ion binding [Term] id: GO:0043169 name: cation binding namespace: molecular_function def: "Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl] subset: gosubset_prok is_a: GO:0043167 ! ion binding [Term] id: GO:0043170 name: macromolecule metabolic process namespace: biological_process alt_id: GO:0043283 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0043171 name: peptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl] subset: gosubset_prok synonym: "peptide breakdown" EXACT [] synonym: "peptide catabolism" EXACT [] synonym: "peptide degradation" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0043172 name: ferredoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ferredoxin anabolism" EXACT [] synonym: "ferredoxin biosynthesis" EXACT [] synonym: "ferredoxin formation" EXACT [] synonym: "ferredoxin synthesis" EXACT [] is_a: GO:0006124 ! ferredoxin metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:0043173 name: nucleotide salvage namespace: biological_process def: "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok xref: Wikipedia:Nucleotide_salvage is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0043174 name: nucleoside salvage namespace: biological_process def: "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0043175 name: RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme." [GOC:jl, GOC:txnOH] subset: gosubset_prok is_a: GO:0070063 ! RNA polymerase binding [Term] id: GO:0043176 name: amine binding namespace: molecular_function def: "Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0043177 name: organic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0043178 name: alcohol binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0043179 name: rhythmic excitation namespace: biological_process def: "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433] is_a: GO:0060024 ! rhythmic synaptic transmission [Term] id: GO:0043180 name: rhythmic inhibition namespace: biological_process def: "Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit." [GOC:go_curators] is_a: GO:0060024 ! rhythmic synaptic transmission [Term] id: GO:0043181 name: vacuolar sequestering namespace: biological_process def: "The process of transporting a substance into, and confining within, a vacuole." [GOC:jl] synonym: "retention in vacuole" EXACT [] synonym: "sequestering in vacuole" EXACT [] synonym: "sequestration in vacuole" EXACT [] synonym: "storage in vacuole" EXACT [] synonym: "vacuolar retention" EXACT [] synonym: "vacuolar sequestration" EXACT [] synonym: "vacuolar storage" EXACT [] is_a: GO:0051651 ! maintenance of location in cell [Term] id: GO:0043182 name: vacuolar sequestering of sodium ion namespace: biological_process def: "The process of transporting sodium ions into, and confining within, a vacuole." [GOC:jl] synonym: "sequestering of sodium ion (Na+) in vacuole" EXACT [] synonym: "sequestration of sodium ion (Na+) in vacuole" EXACT [] synonym: "sodium ion (Na+) retention in vacuole" EXACT [] synonym: "sodium ion (Na+) storage in vacuole" EXACT [] synonym: "vacuolar sequestering of sodium ion (Na+)" EXACT [] synonym: "vacuolar sequestration of sodium ion (Na+)" EXACT [] synonym: "vacuolar sodium ion (Na+) retention" EXACT [] synonym: "vacuolar sodium ion (Na+) storage" EXACT [] is_a: GO:0043181 ! vacuolar sequestering relationship: part_of GO:0006883 ! cellular sodium ion homeostasis [Term] id: GO:0043183 name: vascular endothelial growth factor receptor 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1." [GOC:st] synonym: "Flt-1 binding" EXACT [] synonym: "VEGF receptor 1 binding" EXACT [] synonym: "VEGFR 1 binding" EXACT [] is_a: GO:0005172 ! vascular endothelial growth factor receptor binding [Term] id: GO:0043184 name: vascular endothelial growth factor receptor 2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2." [GOC:st] synonym: "Flk-1 binding" EXACT [] synonym: "KDR binding" BROAD [] synonym: "kinase domain region binding" EXACT [] synonym: "VEGF receptor 2 binding" EXACT [] synonym: "VEGFR 2 binding" EXACT [] is_a: GO:0005172 ! vascular endothelial growth factor receptor binding [Term] id: GO:0043185 name: vascular endothelial growth factor receptor 3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3." [GOC:st] synonym: "fms-like-tyrosine kinase (Flt)-4 binding" EXACT [] synonym: "VEGF receptor 3 binding" EXACT [] synonym: "VEGFR 3 binding" EXACT [] is_a: GO:0005172 ! vascular endothelial growth factor receptor binding [Term] id: GO:0043186 name: P granule namespace: cellular_component alt_id: GO:0018994 def: "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] synonym: "germline granule" EXACT [] synonym: "nuage" BROAD [] synonym: "polar granule" EXACT [] is_a: GO:0035770 ! RNA granule relationship: part_of GO:0060293 ! germ plasm [Term] id: GO:0043187 name: cell septum surface namespace: cellular_component def: "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators] synonym: "septum surface" BROAD [] is_a: GO:0044457 ! cell septum part [Term] id: GO:0043188 name: cell septum edging namespace: cellular_component def: "The cell wall material that surrounds the septum in fungal cells." [GOC:vw] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009277 ! fungal-type cell wall [Term] id: GO:0043189 name: H4/H2A histone acetyltransferase complex namespace: cellular_component def: "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah] synonym: "H4/H2A HAT complex" EXACT [] is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0043190 name: ATP-binding cassette (ABC) transporter complex namespace: cellular_component alt_id: GO:0043191 alt_id: GO:0043192 def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107] subset: goslim_pir subset: gosubset_prok synonym: "ABC-type efflux permease complex" NARROW [] synonym: "ABC-type efflux porter complex" NARROW [] synonym: "ABC-type uptake permease complex" NARROW [] synonym: "ATP-binding cassette (ABC) transporter complex" RELATED [] synonym: "mating pheromone exporter" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part [Term] id: GO:0043194 name: initial segment namespace: cellular_component def: "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln] xref: NIF_Subcellular:sao256000789 is_a: GO:0033267 ! axon part relationship: part_of GO:0044304 ! main axon [Term] id: GO:0043195 name: terminal button namespace: cellular_component def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:nln] synonym: "bouton" EXACT [] synonym: "presynaptic bouton" EXACT [] synonym: "synaptic bouton" EXACT [] synonym: "terminal bouton" EXACT [] is_a: GO:0033267 ! axon part is_a: GO:0044456 ! synapse part relationship: part_of GO:0043679 ! axon terminus [Term] id: GO:0043196 name: varicosity namespace: cellular_component def: "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln] is_a: GO:0033267 ! axon part relationship: part_of GO:0044304 ! main axon [Term] id: GO:0043197 name: dendritic spine namespace: cellular_component def: "Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln] synonym: "dendrite spine" EXACT [] xref: NIF_Subcellular:sao1799103720 xref: Wikipedia:Dendritic_spine is_a: GO:0044309 ! neuron spine is_a: GO:0044463 ! cell projection part relationship: part_of GO:0030425 ! dendrite [Term] id: GO:0043198 name: dendritic shaft namespace: cellular_component def: "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln] xref: NIF_Subcellular:sao2034472720 is_a: GO:0044463 ! cell projection part relationship: part_of GO:0030425 ! dendrite [Term] id: GO:0043199 name: sulfate binding namespace: molecular_function def: "Interacting selectively and non-covalently with sulfate, SO4(2-), a negatively charged small molecule." [GOC:mlg] subset: gosubset_prok is_a: GO:0043168 ! anion binding [Term] id: GO:0043200 name: response to amino acid stimulus namespace: biological_process alt_id: GO:0010237 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:ef, GOC:mlg] synonym: "response to amino acid" EXACT [] is_a: GO:0001101 ! response to acid is_a: GO:0014075 ! response to amine stimulus [Term] id: GO:0043201 name: response to leucine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mlg] is_a: GO:0043200 ! response to amino acid stimulus [Term] id: GO:0043202 name: lysosomal lumen namespace: cellular_component def: "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0043203 name: axon hillock namespace: cellular_component def: "Portion of the neuronal cell soma from which the axon originates." [GOC:nln] xref: NIF_Subcellular:sao627227260 xref: Wikipedia:Axon_hillock is_a: GO:0033267 ! axon part relationship: part_of GO:0043025 ! neuronal cell body [Term] id: GO:0043204 name: perikaryon namespace: cellular_component def: "The portion of the cell soma (cell body) that excludes the nucleus." [GOC:jl] synonym: "cell soma cytoplasm" RELATED [] is_a: GO:0044464 ! cell part relationship: part_of GO:0043025 ! neuronal cell body [Term] id: GO:0043205 name: fibril namespace: cellular_component def: "Extracellular matrix material consisting of polysaccharides and protein." [PMID:12704238] is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0043206 name: fibril organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, extracellular matrix material consisting of polysaccharides and protein." [GOC:mlg] synonym: "fibril organisation" EXACT [GOC:curators] synonym: "fibril organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization [Term] id: GO:0043207 name: response to external biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] subset: gosubset_prok is_a: GO:0009605 ! response to external stimulus is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0043208 name: glycosphingolipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl] is_a: GO:0046625 ! sphingolipid binding is_a: GO:0051861 ! glycolipid binding [Term] id: GO:0043209 name: myelin sheath namespace: cellular_component def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:jl, NIF_Subcellular:sao-593830697, Wikipedia:Myelin] synonym: "Schwann Cell Myelin Sheath" EXACT [] xref: NIF_Subcellular:sao-593830697 xref: Wikipedia:Myelin is_a: GO:0044464 ! cell part [Term] id: GO:0043210 name: alkanesulfonate binding namespace: molecular_function def: "Interacting selectively and non-covalently with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:mlg] subset: gosubset_prok is_a: GO:0043168 ! anion binding [Term] id: GO:0043211 name: carbohydrate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane." [GOC:mlg] subset: gosubset_prok synonym: "carbohydrate ABC transporter" NARROW [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0043212 name: carbohydrate-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) = ADP + phosphate + carbohydrate(out)." [GOC:mlg] subset: gosubset_prok is_a: GO:0043211 ! carbohydrate-transporting ATPase activity [Term] id: GO:0043213 name: bacteriocin transport namespace: biological_process def: "The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain." [GOC:mlg] subset: gosubset_prok is_a: GO:0015031 ! protein transport [Term] id: GO:0043214 name: bacteriocin-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of bacteriocins across a membrane." [GOC:mlg] synonym: "bacteriocin ABC transporter" NARROW [] is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity is_a: GO:0022885 ! bacteriocin transmembrane transporter activity [Term] id: GO:0043215 name: daunorubicin transport namespace: biological_process def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg, http://www.mercksource.com/] is_a: GO:0015893 ! drug transport [Term] id: GO:0043216 name: daunorubicin-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out)." [GOC:mlg] synonym: "daunorubicin ABC transporter" NARROW [] is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0043217 name: myelin maintenance namespace: biological_process def: "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." [GOC:dgh] is_a: GO:0007009 ! plasma membrane organization relationship: part_of GO:0042552 ! myelination [Term] id: GO:0043218 name: compact myelin namespace: cellular_component def: "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh, NIF_Subcellular:sao-1123256993] synonym: "Schwann Cell Compact Myelin" EXACT [] xref: NIF_Subcellular:sao-1123256993 is_a: GO:0044464 ! cell part relationship: part_of GO:0043209 ! myelin sheath [Term] id: GO:0043219 name: lateral loop namespace: cellular_component def: "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh] is_a: GO:0044464 ! cell part relationship: part_of GO:0043209 ! myelin sheath [Term] id: GO:0043220 name: Schmidt-Lanterman incisure namespace: cellular_component alt_id: GO:0044287 def: "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh] synonym: "Schmidt-Lanterman cleft" EXACT [] xref: NIF_Subcellular:sao254777664 is_a: GO:0044464 ! cell part relationship: part_of GO:0043218 ! compact myelin [Term] id: GO:0043221 name: SMC protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization." [GOC:jl, PMID:9640531] is_a: GO:0005515 ! protein binding [Term] id: GO:0043223 name: cytoplasmic SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "cytoplasmic cullin complex" EXACT [] synonym: "cytoplasmic SCF complex" EXACT [] synonym: "cytoplasmic Skp1/Cul1/F-box protein complex" EXACT [] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex is_a: GO:0019005 ! SCF ubiquitin ligase complex [Term] id: GO:0043224 name: nuclear SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "nuclear cullin complex" EXACT [] synonym: "nuclear SCF complex" EXACT [] synonym: "nuclear Skp1/Cul1/F-box protein complex" EXACT [] is_a: GO:0000152 ! nuclear ubiquitin ligase complex is_a: GO:0019005 ! SCF ubiquitin ligase complex [Term] id: GO:0043225 name: anion transmembrane-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in)." [GOC:mlg] subset: gosubset_prok synonym: "anion ABC transporter" NARROW [] synonym: "anion-transporting ATPase activity" EXACT [] is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_generic subset: goslim_pir subset: gosubset_prok xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0005575 ! cellular_component [Term] id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: gosubset_prok synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle [Term] id: GO:0043228 name: non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: gosubset_prok synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 is_a: GO:0043226 ! organelle [Term] id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok is_a: GO:0043226 ! organelle is_a: GO:0044424 ! intracellular part [Term] id: GO:0043230 name: extracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] subset: goslim_pir subset: gosubset_prok is_a: GO:0043226 ! organelle is_a: GO:0044421 ! extracellular region part [Term] id: GO:0043231 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0043232 name: intracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0043233 name: organelle lumen namespace: cellular_component def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] is_a: GO:0031974 ! membrane-enclosed lumen is_a: GO:0044422 ! organelle part [Term] id: GO:0043234 name: protein complex namespace: cellular_component def: "Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators] subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "protein-protein complex" EXACT [] xref: Wikipedia:Protein_complex is_a: GO:0032991 ! macromolecular complex [Term] id: GO:0043235 name: receptor complex namespace: cellular_component def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex [Term] id: GO:0043236 name: laminin binding namespace: molecular_function def: "Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells." [GOC:ecd] is_a: GO:0005515 ! protein binding is_a: GO:0050840 ! extracellular matrix binding [Term] id: GO:0043237 name: laminin-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1." [GOC:go_curators] is_a: GO:0043236 ! laminin binding [Term] id: GO:0043238 name: laminin-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with laminin-2, a glycoprotein trimer with the subunit composition alpha2, beta1, gamma 1." [GOC:go_curators] is_a: GO:0043236 ! laminin binding [Term] id: GO:0043239 name: laminin-4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with laminin-4, a glycoprotein trimer with the subunit composition alpha2, beta2, gamma 1." [GOC:go_curators] is_a: GO:0043236 ! laminin binding [Term] id: GO:0043240 name: Fanconi anaemia nuclear complex namespace: cellular_component def: "A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742] synonym: "FA complex" EXACT [] synonym: "FA core complex" EXACT [] synonym: "FA nuclear complex" EXACT [] synonym: "Fanconi anaemia complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0043241 name: protein complex disassembly namespace: biological_process def: "The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl] subset: gosubset_prok is_a: GO:0032984 ! macromolecular complex disassembly is_a: GO:0071822 ! protein complex subunit organization [Term] id: GO:0043242 name: negative regulation of protein complex disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "down regulation of protein complex disassembly" EXACT [] synonym: "down-regulation of protein complex disassembly" EXACT [] synonym: "downregulation of protein complex disassembly" EXACT [] synonym: "inhibition of protein complex disassembly" NARROW [] is_a: GO:0043244 ! regulation of protein complex disassembly is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0043241 ! protein complex disassembly [Term] id: GO:0043243 name: positive regulation of protein complex disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "activation of protein complex disassembly" NARROW [] synonym: "stimulation of protein complex disassembly" NARROW [] synonym: "up regulation of protein complex disassembly" EXACT [] synonym: "up-regulation of protein complex disassembly" EXACT [] synonym: "upregulation of protein complex disassembly" EXACT [] is_a: GO:0043244 ! regulation of protein complex disassembly is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0043241 ! protein complex disassembly [Term] id: GO:0043244 name: regulation of protein complex disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] subset: gosubset_prok is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0043241 ! protein complex disassembly [Term] id: GO:0043245 name: extraorganismal space namespace: cellular_component def: "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl] subset: gosubset_prok is_a: GO:0044421 ! extracellular region part [Term] id: GO:0043246 name: megasome namespace: cellular_component def: "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [PMID:11206117, PMID:1999020] is_a: GO:0005764 ! lysosome [Term] id: GO:0043247 name: telomere maintenance in response to DNA damage namespace: biological_process def: "Any process that occur in response to the presence of critically short telomeres." [PMID:15279784] synonym: "DNA damage response, telomere maintenance" EXACT [GOC:curators] is_a: GO:0000723 ! telomere maintenance is_a: GO:0006974 ! response to DNA damage stimulus [Term] id: GO:0043248 name: proteasome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471] subset: gosubset_prok synonym: "26S proteasome assembly" NARROW [] synonym: "proteasome complex assembly" EXACT [] synonym: "proteasome maturation" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0043249 name: erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl] synonym: "RBC maturation" EXACT [CL:0000232] synonym: "red blood cell maturation" EXACT [CL:0000232] is_a: GO:0048469 ! cell maturation relationship: part_of GO:0048821 ! erythrocyte development [Term] id: GO:0043250 name: sodium-dependent organic anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner." [GOC:go_curators] is_a: GO:0008514 ! organic anion transmembrane transporter activity [Term] id: GO:0043251 name: sodium-dependent organic anion transport namespace: biological_process def: "The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015711 ! organic anion transport [Term] id: GO:0043252 name: sodium-independent organic anion transport namespace: biological_process def: "The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] xref: Reactome:1253491 "Transport of organic anions" xref: Reactome:1280430 "Transport of organic anions" xref: Reactome:1299262 "Transport of organic anions" xref: Reactome:1327008 "Transport of organic anions" xref: Reactome:1353102 "Transport of organic anions" xref: Reactome:1373291 "Transport of organic anions" xref: Reactome:1393304 "Transport of organic anions" xref: Reactome:1417802 "Transport of organic anions" xref: Reactome:879518 "Transport of organic anions" is_a: GO:0015711 ! organic anion transport [Term] id: GO:0043253 name: chloroplast ribosome namespace: cellular_component def: "A ribosome contained within a chloroplast." [GOC:ecd] is_a: GO:0009547 ! plastid ribosome is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0043254 name: regulation of protein complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] subset: gosubset_prok is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0006461 ! protein complex assembly [Term] id: GO:0043255 name: regulation of carbohydrate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl] subset: gosubset_prok synonym: "regulation of carbohydrate anabolism" EXACT [] synonym: "regulation of carbohydrate biosynthesis" EXACT [] synonym: "regulation of carbohydrate formation" EXACT [] synonym: "regulation of carbohydrate synthesis" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009889 ! regulation of biosynthetic process relationship: regulates GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0043256 name: laminin complex namespace: cellular_component def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005605 ! basal lamina [Term] id: GO:0043257 name: laminin-8 complex namespace: cellular_component def: "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043258 name: laminin-9 complex namespace: cellular_component def: "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043259 name: laminin-10 complex namespace: cellular_component def: "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043260 name: laminin-11 complex namespace: cellular_component def: "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043261 name: laminin-12 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043262 name: adenosine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + H2O = AMP + phosphate." [EC:3.6.1.5, PMID:1470606] synonym: "adenosine diphosphatase activity" EXACT [] synonym: "adenosinepyrophosphatase activity" EXACT [EC:3.6.1.6] synonym: "ADPase" BROAD [EC:3.6.1.3] synonym: "ADPase activity" EXACT [EC:3.6.1.6] synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.3] synonym: "ATP diphosphohydrolase (phosphate-forming) activity" EXACT [EC:3.6.1.3] synonym: "ATP-diphosphatase activity" EXACT [EC:3.6.1.3] synonym: "ATP-diphosphohydrolase activity" EXACT [EC:3.6.1.3] xref: MetaCyc:APYRASE-RXN is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0043263 name: cellulosome namespace: cellular_component def: "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609] subset: gosubset_prok xref: Wikipedia:Cellulosome is_a: GO:0043264 ! extracellular non-membrane-bounded organelle [Term] id: GO:0043264 name: extracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl] subset: gosubset_prok synonym: "extracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043230 ! extracellular organelle [Term] id: GO:0043265 name: ectoplasm namespace: cellular_component def: "Granule free cytoplasm, lying immediately below the plasma membrane." [GOC:curators, PMID:12211103] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0043266 name: regulation of potassium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "regulation of K+ conductance" NARROW [] synonym: "regulation of K+ transport" EXACT [] synonym: "regulation of potassium conductance" NARROW [] synonym: "regulation of potassium ion conductance" NARROW [] synonym: "regulation of potassium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport relationship: regulates GO:0006813 ! potassium ion transport [Term] id: GO:0043267 name: negative regulation of potassium ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of potassium ion transport" EXACT [] synonym: "down-regulation of potassium ion transport" EXACT [] synonym: "downregulation of potassium ion transport" EXACT [] synonym: "inhibition of potassium ion transport" NARROW [] synonym: "negative regulation of K+ transport" EXACT [] synonym: "negative regulation of potassium ion conductance" NARROW [] synonym: "negative regulation of potassium transport" EXACT [] synonym: "regulation of K+ conductance" NARROW [] synonym: "regulation of potassium conductance" NARROW [] synonym: "transmembrane conductance regulator activity" RELATED [] is_a: GO:0043266 ! regulation of potassium ion transport is_a: GO:0043271 ! negative regulation of ion transport relationship: negatively_regulates GO:0006813 ! potassium ion transport [Term] id: GO:0043268 name: positive regulation of potassium ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of potassium ion transport" NARROW [] synonym: "positive regulation of K+ conductance" NARROW [] synonym: "positive regulation of K+ transport" EXACT [] synonym: "positive regulation of potassium conductance" NARROW [] synonym: "positive regulation of potassium ion conductance" NARROW [] synonym: "positive regulation of potassium transport" EXACT [] synonym: "stimulation of potassium ion transport" NARROW [] synonym: "up regulation of potassium ion transport" EXACT [] synonym: "up-regulation of potassium ion transport" EXACT [] synonym: "upregulation of potassium ion transport" EXACT [] is_a: GO:0043266 ! regulation of potassium ion transport is_a: GO:0043270 ! positive regulation of ion transport relationship: positively_regulates GO:0006813 ! potassium ion transport [Term] id: GO:0043269 name: regulation of ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0006811 ! ion transport [Term] id: GO:0043270 name: positive regulation of ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of ion transport" NARROW [] synonym: "stimulation of ion transport" NARROW [] synonym: "up regulation of ion transport" EXACT [] synonym: "up-regulation of ion transport" EXACT [] synonym: "upregulation of ion transport" EXACT [] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0006811 ! ion transport [Term] id: GO:0043271 name: negative regulation of ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of ion transport" EXACT [] synonym: "down-regulation of ion transport" EXACT [] synonym: "downregulation of ion transport" EXACT [] synonym: "inhibition of ion transport" NARROW [] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0006811 ! ion transport [Term] id: GO:0043272 name: ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance." [GOC:jl] synonym: "ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance" RELATED [] synonym: "ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb] synonym: "ethylene formation during jasmonic acid and ethylene-dependent systemic resistance" RELATED [] synonym: "ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance" RELATED [] is_a: GO:0009693 ! ethylene biosynthetic process relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0043273 name: CTPase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators] synonym: "cytidine triphosphatase activity" EXACT [] is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0043274 name: phospholipase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0043275 name: glutamate carboxypeptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [BRENDA:3.4.17.21, GOC:jl] comment: This term was made obsolete because it represents a gene product. synonym: "acetylaspartylglutamate dipeptidase activity" EXACT [] synonym: "folate hydrolase activity" RELATED [EC:3.4.17.21] synonym: "folylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "membrane glutamate carboxypeptidase" NARROW [EC:3.4.17.21] synonym: "mGCP" RELATED [EC:3.4.17.21] synonym: "microsomal gamma-glutamyl carboxypeptidase" NARROW [EC:3.4.17.21] synonym: "N-acetylated alpha-linked acidic dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "N-acetylated-alpha-linked-amino dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)" EXACT [EC:3.4.17.21] synonym: "N-acetylated-gamma-linked-acidic dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "NAALA dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "NAALADase activity" EXACT [EC:3.4.17.21] synonym: "prostate-specific membrane antigen" RELATED [EC:3.4.17.21] synonym: "prostrate-specific membrane antigen" RELATED [EC:3.4.17.21] synonym: "PSM antigen" RELATED [EC:3.4.17.21] synonym: "PSMA" RELATED [EC:3.4.17.21] synonym: "pteroylpoly-gamma-glutamate carboxypeptidase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpoly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolygammaglutamyl hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolyglutamic acid hydrolase activity" EXACT [EC:3.4.17.21] synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21] xref: EC:3.4.17.21 is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0043276 name: anoikis namespace: biological_process def: "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, http://www.copewithcytokines.de/] synonym: "detachment induced cell death" EXACT [] synonym: "suspension induced apoptosis" EXACT [] xref: Wikipedia:Anoikis is_a: GO:0006915 ! apoptosis [Term] id: GO:0043277 name: apoptotic cell clearance namespace: biological_process def: "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684] comment: Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells. synonym: "apoptotic cell removal" EXACT [] synonym: "efferocytosis" EXACT [PMID:17548650] synonym: "programmed cell clearance" EXACT [] is_a: GO:0006909 ! phagocytosis [Term] id: GO:0043278 name: response to morphine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [CHEBI:17303, GOC:ef, GOC:jl] is_a: GO:0014072 ! response to isoquinoline alkaloid [Term] id: GO:0043279 name: response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [CHEBI:22315, GOC:jl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0043280 name: positive regulation of caspase activity namespace: biological_process def: "Any process that activates or increases the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl] synonym: "activation of caspase activity" NARROW [] synonym: "stimulation of caspase activity" NARROW [] synonym: "up regulation of caspase activity" EXACT [] synonym: "up-regulation of caspase activity" EXACT [] synonym: "upregulation of caspase activity" EXACT [] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:0043281 ! regulation of caspase activity [Term] id: GO:0043281 name: regulation of caspase activity namespace: biological_process alt_id: GO:0043026 def: "Any process that modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl] synonym: "regulation of caspase activation" NARROW [] is_a: GO:0042981 ! regulation of apoptosis is_a: GO:0052548 ! regulation of endopeptidase activity [Term] id: GO:0043282 name: pharyngeal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx." [GOC:go_curators] is_a: GO:0007517 ! muscle organ development relationship: part_of GO:0060465 ! pharynx development [Term] id: GO:0043286 name: regulation of poly(3-hydroxyalkanoate) biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl] subset: gosubset_prok synonym: "regulation of PHA" EXACT [] synonym: "regulation of poly(3-hydroxyalkanoate) anabolism" EXACT [] synonym: "regulation of poly(3-hydroxyalkanoate) biosynthesis" EXACT [] synonym: "regulation of poly(3-hydroxyalkanoate) formation" EXACT [] synonym: "regulation of poly(3-hydroxyalkanoate) synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process relationship: regulates GO:0042621 ! poly(3-hydroxyalkanoate) biosynthetic process [Term] id: GO:0043287 name: poly(3-hydroxyalkanoate) binding namespace: molecular_function def: "Interacting selectively and non-covalently with poly(3-hydroxyalkanoate)s, polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl] subset: gosubset_prok synonym: "PHA binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0043288 name: apocarotenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm] subset: gosubset_prok synonym: "apocarotenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0043289 name: apocarotenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm] subset: gosubset_prok synonym: "apocarotenoid anabolism" EXACT [] synonym: "apocarotenoid biosynthesis" EXACT [] synonym: "apocarotenoid formation" EXACT [] synonym: "apocarotenoid synthesis" EXACT [] is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0043288 ! apocarotenoid metabolic process [Term] id: GO:0043290 name: apocarotenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm] subset: gosubset_prok synonym: "apocarotenoid breakdown" EXACT [] synonym: "apocarotenoid catabolism" EXACT [] synonym: "apocarotenoid degradation" EXACT [] is_a: GO:0016115 ! terpenoid catabolic process is_a: GO:0043288 ! apocarotenoid metabolic process [Term] id: GO:0043291 name: RAVE complex namespace: cellular_component def: "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802] synonym: "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0043292 name: contractile fiber namespace: cellular_component def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] synonym: "contractile fibre" EXACT [] synonym: "muscle fiber" BROAD [] synonym: "muscle fibre" BROAD [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0043293 name: apoptosome namespace: cellular_component def: "A multisubunit protein complex involved in the activation of apoptosis. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137] xref: Wikipedia:Apoptosome is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0043294 name: mitochondrial glutamate synthase complex (NADH) namespace: cellular_component def: "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] is_a: GO:0031027 ! glutamate synthase complex (NADH) is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0043295 name: glutathione binding namespace: molecular_function def: "Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042277 ! peptide binding is_a: GO:0072341 ! modified amino acid binding [Term] id: GO:0043296 name: apical junction complex namespace: cellular_component def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, PMID:12525486, PMID:15196556] synonym: "apical cell junction complex" EXACT [GOC:mah] is_a: GO:0005911 ! cell-cell junction relationship: part_of GO:0016327 ! apicolateral plasma membrane [Term] id: GO:0043297 name: apical junction assembly namespace: biological_process def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556] synonym: "apical junction complex assembly" EXACT [GOC:mah] is_a: GO:0007043 ! cell-cell junction assembly [Term] id: GO:0043299 name: leukocyte degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "immune cell degranulation" EXACT [] synonym: "immune cell granule exocytosis" EXACT [] synonym: "leucocyte degranulation" EXACT [] synonym: "leukocyte granule exocytosis" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0045055 ! regulated secretory pathway [Term] id: GO:0043300 name: regulation of leukocyte degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of immune cell degranulation" EXACT [] synonym: "regulation of immune cell granule exocytosis" EXACT [] synonym: "regulation of leucocyte degranulation" EXACT [] synonym: "regulation of leukocyte granule exocytosis" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0017157 ! regulation of exocytosis relationship: regulates GO:0043299 ! leukocyte degranulation [Term] id: GO:0043301 name: negative regulation of leukocyte degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of leukocyte degranulation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of leukocyte degranulation" EXACT [] synonym: "down-regulation of leukocyte degranulation" EXACT [] synonym: "downregulation of leukocyte degranulation" EXACT [] synonym: "inhibition of leukocyte degranulation" NARROW [] synonym: "negative regulation of immune cell degranulation" EXACT [] synonym: "negative regulation of leucocyte degranulation" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0045920 ! negative regulation of exocytosis relationship: negatively_regulates GO:0043299 ! leukocyte degranulation [Term] id: GO:0043302 name: positive regulation of leukocyte degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of leukocyte degranulation" NARROW [] synonym: "positive regulation of immune cell degranulation" EXACT [] synonym: "positive regulation of leucocyte degranulation" EXACT [] synonym: "stimulation of leukocyte degranulation" NARROW [] synonym: "up regulation of leukocyte degranulation" EXACT [] synonym: "up-regulation of leukocyte degranulation" EXACT [] synonym: "upregulation of leukocyte degranulation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0045921 ! positive regulation of exocytosis relationship: positively_regulates GO:0043299 ! leukocyte degranulation [Term] id: GO:0043303 name: mast cell degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149 "Fundamental Immunology"] synonym: "mast cell granule exocytosis" EXACT [] is_a: GO:0002279 ! mast cell activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002448 ! mast cell mediated immunity [Term] id: GO:0043304 name: regulation of mast cell degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of mast cell granule exocytosis" EXACT [] is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0033006 ! regulation of mast cell activation involved in immune response is_a: GO:0043300 ! regulation of leukocyte degranulation relationship: regulates GO:0043303 ! mast cell degranulation [Term] id: GO:0043305 name: negative regulation of mast cell degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of mast cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of mast cell degranulation" EXACT [] synonym: "down-regulation of mast cell degranulation" EXACT [] synonym: "downregulation of mast cell degranulation" EXACT [] synonym: "inhibition of mast cell degranulation" NARROW [] synonym: "negative regulation of mast cell granule exocytosis" EXACT [] is_a: GO:0033007 ! negative regulation of mast cell activation involved in immune response is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043304 ! regulation of mast cell degranulation relationship: negatively_regulates GO:0043303 ! mast cell degranulation [Term] id: GO:0043306 name: positive regulation of mast cell degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mast cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of mast cell degranulation" NARROW [] synonym: "positive regulation of mast cell granule exocytosis" EXACT [] synonym: "stimulation of mast cell degranulation" NARROW [] synonym: "up regulation of mast cell degranulation" EXACT [] synonym: "up-regulation of mast cell degranulation" EXACT [] synonym: "upregulation of mast cell degranulation" EXACT [] is_a: GO:0033008 ! positive regulation of mast cell activation involved in immune response is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043304 ! regulation of mast cell degranulation relationship: positively_regulates GO:0043303 ! mast cell degranulation [Term] id: GO:0043307 name: eosinophil activation namespace: biological_process def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0043308 name: eosinophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149 "Fundamental Immunology"] synonym: "eosinophil granule exocytosis" EXACT [] is_a: GO:0002278 ! eosinophil activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002447 ! eosinophil mediated immunity [Term] id: GO:0043309 name: regulation of eosinophil degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of eosinophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of eosinophil granule exocytosis" EXACT [] is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0043308 ! eosinophil degranulation [Term] id: GO:0043310 name: negative regulation of eosinophil degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of eosinophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of eosinophil degranulation" EXACT [] synonym: "down-regulation of eosinophil degranulation" EXACT [] synonym: "downregulation of eosinophil degranulation" EXACT [] synonym: "inhibition of eosinophil degranulation" NARROW [] synonym: "negative regulation of eosinophil granule exocytosis" EXACT [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043309 ! regulation of eosinophil degranulation relationship: negatively_regulates GO:0043308 ! eosinophil degranulation [Term] id: GO:0043311 name: positive regulation of eosinophil degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of eosinophil degranulation" NARROW [] synonym: "positive regulation of eosinophil granule exocytosis" EXACT [] synonym: "stimulation of eosinophil degranulation" NARROW [] synonym: "up regulation of eosinophil degranulation" EXACT [] synonym: "up-regulation of eosinophil degranulation" EXACT [] synonym: "upregulation of eosinophil degranulation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043309 ! regulation of eosinophil degranulation relationship: positively_regulates GO:0043308 ! eosinophil degranulation [Term] id: GO:0043312 name: neutrophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149 "Fundamental Immunology"] synonym: "heterophil degranulation" RELATED [] synonym: "neutrophil granule exocytosis" EXACT [] is_a: GO:0002283 ! neutrophil activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002446 ! neutrophil mediated immunity [Term] id: GO:0043313 name: regulation of neutrophil degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of neutrophil granule exocytosis" EXACT [] is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0043312 ! neutrophil degranulation [Term] id: GO:0043314 name: negative regulation of neutrophil degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of neutrophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of neutrophil degranulation" EXACT [] synonym: "down-regulation of neutrophil degranulation" EXACT [] synonym: "downregulation of neutrophil degranulation" EXACT [] synonym: "inhibition of neutrophil degranulation" NARROW [] synonym: "negative regulation of neutrophil granule exocytosis" EXACT [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043313 ! regulation of neutrophil degranulation relationship: negatively_regulates GO:0043312 ! neutrophil degranulation [Term] id: GO:0043315 name: positive regulation of neutrophil degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of neutrophil degranulation" NARROW [] synonym: "positive regulation of neutrophil granule exocytosis" EXACT [] synonym: "stimulation of neutrophil degranulation" NARROW [] synonym: "up regulation of neutrophil degranulation" EXACT [] synonym: "up-regulation of neutrophil degranulation" EXACT [] synonym: "upregulation of neutrophil degranulation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043313 ! regulation of neutrophil degranulation relationship: positively_regulates GO:0043312 ! neutrophil degranulation [Term] id: GO:0043316 name: cytotoxic T cell degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." [ISBN:0781735149 "Fundamental Immunology"] synonym: "cytotoxic T cell granule exocytosis" EXACT [] synonym: "cytotoxic T lymphocyte degranulation" EXACT [] synonym: "cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "cytotoxic T-cell degranulation" EXACT [] synonym: "cytotoxic T-cell granule exocytosis" EXACT [] synonym: "cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "cytotoxic T-lymphocyte granule exocytosis" EXACT [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0043317 name: regulation of cytotoxic T cell degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of cytotoxic T cell granule exocytosis" EXACT [] synonym: "regulation of cytotoxic T lymphocyte degranulation" EXACT [] synonym: "regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "regulation of cytotoxic T-cell degranulation" EXACT [] synonym: "regulation of cytotoxic T-cell granule exocytosis" EXACT [] synonym: "regulation of cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050863 ! regulation of T cell activation relationship: regulates GO:0043316 ! cytotoxic T cell degranulation [Term] id: GO:0043318 name: negative regulation of cytotoxic T cell degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of cytotoxic T cell degranulation" EXACT [] synonym: "down-regulation of cytotoxic T cell degranulation" EXACT [] synonym: "downregulation of cytotoxic T cell degranulation" EXACT [] synonym: "inhibition of cytotoxic T cell degranulation" NARROW [] synonym: "negative regulation of cytotoxic T cell granule exocytosis" EXACT [] synonym: "negative regulation of cytotoxic T lymphocyte degranulation" EXACT [] synonym: "negative regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "negative regulation of cytotoxic T-cell degranulation" EXACT [] synonym: "negative regulation of cytotoxic T-cell granule exocytosis" EXACT [] synonym: "negative regulation of cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "negative regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation is_a: GO:0050868 ! negative regulation of T cell activation relationship: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation [Term] id: GO:0043319 name: positive regulation of cytotoxic T cell degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of cytotoxic T cell degranulation" NARROW [] synonym: "positive regulation of cytotoxic T cell granule exocytosis" EXACT [] synonym: "positive regulation of cytotoxic T lymphocyte degranulation" EXACT [] synonym: "positive regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "positive regulation of cytotoxic T-cell degranulation" EXACT [] synonym: "positive regulation of cytotoxic T-cell granule exocytosis" EXACT [] synonym: "positive regulation of cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "positive regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] synonym: "stimulation of cytotoxic T cell degranulation" NARROW [] synonym: "up regulation of cytotoxic T cell degranulation" EXACT [] synonym: "up-regulation of cytotoxic T cell degranulation" EXACT [] synonym: "upregulation of cytotoxic T cell degranulation" EXACT [] is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation is_a: GO:0050870 ! positive regulation of T cell activation relationship: positively_regulates GO:0043316 ! cytotoxic T cell degranulation [Term] id: GO:0043320 name: natural killer cell degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell." [ISBN:0781735149 "Fundamental Immunology"] synonym: "natural killer cell granule exocytosis" EXACT [] synonym: "NK cell degranulation" EXACT [] synonym: "NK cell granule exocytosis" EXACT [] is_a: GO:0002323 ! natural killer cell activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0043321 name: regulation of natural killer cell degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of natural killer cell granule exocytosis" EXACT [] synonym: "regulation of NK cell degranulation" EXACT [] synonym: "regulation of NK cell granule exocytosis" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity is_a: GO:0043300 ! regulation of leukocyte degranulation relationship: regulates GO:0043320 ! natural killer cell degranulation [Term] id: GO:0043322 name: negative regulation of natural killer cell degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of natural killer cell degranulation" EXACT [] synonym: "down-regulation of natural killer cell degranulation" EXACT [] synonym: "downregulation of natural killer cell degranulation" EXACT [] synonym: "inhibition of natural killer cell degranulation" NARROW [] synonym: "negative regulation of natural killer cell granule exocytosis" EXACT [] synonym: "negative regulation of NK cell degranulation" EXACT [] synonym: "negative regulation of NK cell granule exocytosis" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043321 ! regulation of natural killer cell degranulation relationship: negatively_regulates GO:0043320 ! natural killer cell degranulation [Term] id: GO:0043323 name: positive regulation of natural killer cell degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of natural killer cell degranulation" NARROW [] synonym: "positive regulation of natural killer cell granule exocytosis" EXACT [] synonym: "positive regulation of NK cell degranulation" EXACT [] synonym: "positive regulation of NK cell granule exocytosis" EXACT [] synonym: "stimulation of natural killer cell degranulation" NARROW [] synonym: "up regulation of natural killer cell degranulation" EXACT [] synonym: "up-regulation of natural killer cell degranulation" EXACT [] synonym: "upregulation of natural killer cell degranulation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043321 ! regulation of natural killer cell degranulation relationship: positively_regulates GO:0043320 ! natural killer cell degranulation [Term] id: GO:0043324 name: pigment metabolic process involved in developmental pigmentation namespace: biological_process def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin, occurring during the deposition of coloring matter in an organ or organism." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "pigment metabolic process during developmental pigmentation" RELATED [GOC:dph, GOC:tb] synonym: "pigment metabolism during developmental pigmentation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043474 ! pigment metabolic process involved in pigmentation relationship: part_of GO:0048066 ! developmental pigmentation [Term] id: GO:0043325 name: phosphatidylinositol-3,4-bisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions." [GOC:bf, GOC:go_curators] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0043326 name: chemotaxis to folate namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of folate." [GOC:go_curators] is_a: GO:0006935 ! chemotaxis is_a: GO:0051593 ! response to folic acid [Term] id: GO:0043327 name: chemotaxis to cAMP namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP." [GOC:go_curators] synonym: "chemotaxis to 3',5' cAMP" EXACT [] synonym: "chemotaxis to 3',5'-cAMP" EXACT [] synonym: "chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [] synonym: "chemotaxis to cyclic AMP" EXACT [] is_a: GO:0006935 ! chemotaxis [Term] id: GO:0043328 name: protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway namespace: biological_process def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring that contributes to protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343] synonym: "protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb] synonym: "protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] is_a: GO:0006623 ! protein targeting to vacuole is_a: GO:0032511 ! late endosome to vacuole transport via multivesicular body sorting pathway relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Term] id: GO:0043329 name: protein targeting to membrane involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway namespace: biological_process def: "The process of directing proteins towards a membrane using signals contained within the protein, occurring that contributes to ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway." [GOC:jl] synonym: "protein membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "protein targeting to membrane during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb] synonym: "protein targeting to membrane during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] synonym: "protein-membrane targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "protein-membrane targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] is_a: GO:0006612 ! protein targeting to membrane relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Term] id: GO:0043330 name: response to exogenous dsRNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators] comment: Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'. synonym: "response to exogenous double-stranded RNA" EXACT [] synonym: "response to viral dsRNA" NARROW [] is_a: GO:0043331 ! response to dsRNA [Term] id: GO:0043331 name: response to dsRNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:jl] synonym: "response to double-stranded RNA" EXACT [] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0043332 name: mating projection tip namespace: cellular_component def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc] synonym: "conjugation tube tip" NARROW [] synonym: "shmoo tip" NARROW [] is_a: GO:0030427 ! site of polarized growth is_a: GO:0044463 ! cell projection part relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0043333 name: 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9045837] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043334 name: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043335 name: protein unfolding namespace: biological_process def: "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state." [GOC:mlg] is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0043336 name: site-specific telomere resolvase activity namespace: molecular_function def: "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases." [GOC:jl, PMID:11804598] comment: Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres. synonym: "ResT" NARROW [] synonym: "TelN" NARROW [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0043337 name: CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol." [GOC:jl] synonym: "cardiolipin synthase" BROAD [] synonym: "cardiolipin synthetase" BROAD [] xref: MetaCyc:RXN-8141 is_a: GO:0030572 ! phosphatidyltransferase activity [Term] id: GO:0043338 name: CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol." [GOC:jl, PMID:10960477] synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase" BROAD [] xref: EC:2.7.7.- is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0043353 name: enucleate erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus." [GOC:go_curators] synonym: "enucleate RBC differentiation" EXACT [CL:0000232] synonym: "enucleate red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation [Term] id: GO:0043354 name: enucleate erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators] synonym: "enucleate RBC maturation" EXACT [CL:0000232] synonym: "enucleate red blood cell maturation" EXACT [CL:0000232] is_a: GO:0043249 ! erythrocyte maturation relationship: part_of GO:0048822 ! enucleate erythrocyte development [Term] id: GO:0043362 name: nucleate erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl] synonym: "nucleate RBC maturation" EXACT [CL:0000232] synonym: "nucleate red blood cell maturation" EXACT [CL:0000232] is_a: GO:0043249 ! erythrocyte maturation relationship: part_of GO:0048823 ! nucleate erythrocyte development [Term] id: GO:0043363 name: nucleate erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl] synonym: "nucleate RBC differentiation" EXACT [CL:0000232] synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation [Term] id: GO:0043364 name: catalysis of free radical formation namespace: molecular_function def: "Catalysis of a reaction that generates a free radical, a highly reactive molecule with an unsatisfied electron valence pair." [GOC:jl] subset: goslim_pir synonym: "catalysis of free radical generation" EXACT [] synonym: "catalysis of free-radical biosynthesis" EXACT [] synonym: "catalysis of free-radical formation" EXACT [] synonym: "catalysis of free-radical generation" EXACT [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0043365 name: [formate-C-acetyltransferase]-activating enzyme activity namespace: molecular_function alt_id: GO:0008862 def: "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical." [EC:1.97.1.4, GOC:jl, PMID:18307109] synonym: "[pyruvate formate-lyase]-activating enzyme activity" EXACT [EC:1.97.1.4] synonym: "formate acetyltransferase activating enzyme activity" EXACT [EC:1.97.1.4] synonym: "formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity" EXACT [EC:1.97.1.4] synonym: "formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)" EXACT [EC:1.97.1.4] synonym: "formate-C-acetyltransferase-activating enzyme" RELATED [EC:1.97.1.4] synonym: "PFL activase activity" EXACT [EC:1.97.1.4] synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity" EXACT [EC:1.97.1.4] synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4] xref: EC:1.97.1.4 xref: MetaCyc:TDCEACT-RXN is_a: GO:0016491 ! oxidoreductase activity is_a: GO:0043364 ! catalysis of free radical formation is_a: GO:0070283 ! radical SAM enzyme activity [Term] id: GO:0043366 name: beta selection namespace: biological_process def: "The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell." [ISBN:0781735149 "Fundamental Immunology", PMID:12220932] is_a: GO:0045058 ! T cell selection relationship: part_of GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0043367 name: CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [CL:0000624, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] synonym: "CD4-positive, alpha-beta T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, alpha-beta T-cell differentiation" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0043368 name: positive T cell selection namespace: biological_process def: "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] synonym: "positive T lymphocyte selection" EXACT [] synonym: "positive T-cell selection" EXACT [] synonym: "positive T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection [Term] id: GO:0043369 name: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells." [ISBN:0781735149 "Fundamental Immunology"] synonym: "CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment" EXACT [] synonym: "CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive/CD8-positive, alpha-beta T cell lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0043368 ! positive T cell selection [Term] id: GO:0043370 name: regulation of CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive T-lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] synonym: "regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation relationship: regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043371 name: negative regulation of CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "down-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "downregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "inhibition of CD4-positive, alpha beta T cell differentiation" NARROW [] synonym: "negative regulation of CD4-positive T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha-beta T cell differentiation" EXACT [GOC:bf] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation relationship: negatively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043372 name: positive regulation of CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, alpha beta T cell differentiation" NARROW [] synonym: "positive regulation of CD4-positive T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] synonym: "positive regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "stimulation of CD4-positive, alpha beta T cell differentiation" NARROW [] synonym: "up regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "up-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "upregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation relationship: positively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043373 name: CD4-positive, alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"] synonym: "CD4-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive, alpha-beta T-cell lineage commitment" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment relationship: part_of GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043374 name: CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0043375 name: CD8-positive, alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"] synonym: "CD8-positive, alpha-beta T cell fate commitment" EXACT [] synonym: "CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "CD8-positive, alpha-beta T-cell lineage commitment" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment relationship: part_of GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043376 name: regulation of CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD8-positive T lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive T-cell differentiation" EXACT [] synonym: "regulation of CD8-positive T-lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation relationship: regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043377 name: negative regulation of CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "down-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "downregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "inhibition of CD8-positive, alpha-beta T cell differentiation" NARROW [] synonym: "negative regulation of CD8-positive T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive T-cell differentiation" EXACT [] synonym: "negative regulation of CD8-positive T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation relationship: negatively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043378 name: positive regulation of CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD8-positive, alpha-beta T cell differentiation" NARROW [] synonym: "positive regulation of CD8-positive T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive T-cell differentiation" EXACT [] synonym: "positive regulation of CD8-positive T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] synonym: "stimulation of CD8-positive, alpha-beta T cell differentiation" NARROW [] synonym: "up regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "up-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "upregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation relationship: positively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043379 name: memory T cell differentiation namespace: biological_process def: "The process in which a newly activated T cell acquires specialized features of a memory T cell." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "memory T cell development" RELATED [GOC:add] synonym: "memory T lymphocyte differentiation" EXACT [] synonym: "memory T-cell differentiation" EXACT [] synonym: "memory T-lymphocyte differentiation" EXACT [] is_a: GO:0002292 ! T cell differentiation involved in immune response [Term] id: GO:0043380 name: regulation of memory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of memory T cell development" RELATED [GOC:add] synonym: "regulation of memory T lymphocyte differentiation" EXACT [] synonym: "regulation of memory T-cell differentiation" EXACT [] synonym: "regulation of memory T-lymphocyte differentiation" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0043379 ! memory T cell differentiation [Term] id: GO:0043381 name: negative regulation of memory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of memory T cell differentiation" EXACT [] synonym: "down-regulation of memory T cell differentiation" EXACT [] synonym: "downregulation of memory T cell differentiation" EXACT [] synonym: "inhibition of memory T cell differentiation" NARROW [] synonym: "negative regulation of memory T cell development" RELATED [GOC:add] synonym: "negative regulation of memory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of memory T-cell differentiation" EXACT [] synonym: "negative regulation of memory T-lymphocyte differentiation" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0043380 ! regulation of memory T cell differentiation is_a: GO:0045581 ! negative regulation of T cell differentiation relationship: negatively_regulates GO:0043379 ! memory T cell differentiation [Term] id: GO:0043382 name: positive regulation of memory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of memory T cell differentiation" NARROW [] synonym: "positive regulation of memory T cell development" RELATED [GOC:add] synonym: "positive regulation of memory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of memory T-cell differentiation" EXACT [] synonym: "positive regulation of memory T-lymphocyte differentiation" EXACT [] synonym: "stimulation of memory T cell differentiation" NARROW [] synonym: "up regulation of memory T cell differentiation" EXACT [] synonym: "up-regulation of memory T cell differentiation" EXACT [] synonym: "upregulation of memory T cell differentiation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043380 ! regulation of memory T cell differentiation is_a: GO:0045582 ! positive regulation of T cell differentiation relationship: positively_regulates GO:0043379 ! memory T cell differentiation [Term] id: GO:0043383 name: negative T cell selection namespace: biological_process def: "The process of elimination of immature T cells which react strongly with self-antigens." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] synonym: "negative T lymphocyte selection" EXACT [] synonym: "negative T-cell selection" EXACT [] synonym: "negative T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection [Term] id: GO:0043384 name: pre-T cell receptor complex namespace: cellular_component def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149 "Fundamental Immunology", PMID:12220932] synonym: "pre-T lymphocyte receptor complex" EXACT [] synonym: "pre-T-cell receptor complex" EXACT [] synonym: "pre-T-lymphocyte receptor complex" EXACT [] synonym: "pre-TCR complex" EXACT [] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0043385 name: mycotoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [CHEBI:25442, GOC:jl] subset: gosubset_prok synonym: "mycotoxin metabolism" EXACT [] is_a: GO:0009404 ! toxin metabolic process [Term] id: GO:0043386 name: mycotoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [CHEBI:25442, GOC:jl] subset: gosubset_prok synonym: "mycotoxin anabolism" EXACT [] synonym: "mycotoxin biosynthesis" EXACT [] synonym: "mycotoxin formation" EXACT [] synonym: "mycotoxin synthesis" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0043385 ! mycotoxin metabolic process [Term] id: GO:0043387 name: mycotoxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus." [CHEBI:25442, GOC:jl] subset: gosubset_prok synonym: "mycotoxin breakdown" EXACT [] synonym: "mycotoxin catabolism" EXACT [] synonym: "mycotoxin degradation" EXACT [] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0043385 ! mycotoxin metabolic process [Term] id: GO:0043388 name: positive regulation of DNA binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] subset: gosubset_prok synonym: "activation of DNA binding" NARROW [] synonym: "stimulation of DNA binding" NARROW [] synonym: "up regulation of DNA binding" EXACT [] synonym: "up-regulation of DNA binding" EXACT [] synonym: "upregulation of DNA binding" EXACT [] is_a: GO:0051099 ! positive regulation of binding is_a: GO:0051101 ! regulation of DNA binding [Term] id: GO:0043390 name: aflatoxin B1 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi." [CHEBI:2504, GOC:jl] synonym: "aflatoxin B1 metabolism" EXACT [] is_a: GO:0046222 ! aflatoxin metabolic process [Term] id: GO:0043391 name: aflatoxin B2 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aflatoxin B2, a mycotoxin produced by the fungal species Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius." [GOC:jl, http://www.aspergillus.man.ac.uk/] synonym: "aflatoxin B2 metabolism" EXACT [] is_a: GO:0046222 ! aflatoxin metabolic process [Term] id: GO:0043392 name: negative regulation of DNA binding namespace: biological_process def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] subset: gosubset_prok synonym: "down regulation of DNA binding" EXACT [] synonym: "down-regulation of DNA binding" EXACT [] synonym: "downregulation of DNA binding" EXACT [] synonym: "inhibition of DNA binding" NARROW [] is_a: GO:0051100 ! negative regulation of binding is_a: GO:0051101 ! regulation of DNA binding [Term] id: GO:0043393 name: regulation of protein binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators] subset: gosubset_prok is_a: GO:0051098 ! regulation of binding [Term] id: GO:0043394 name: proteoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0001948 ! glycoprotein binding [Term] id: GO:0043395 name: heparan sulfate proteoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "heparin proteoglycan binding" RELATED [] is_a: GO:0043394 ! proteoglycan binding [Term] id: GO:0043396 name: corticotropin-releasing hormone secretion namespace: biological_process def: "The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle." [GOC:go_curators, PMID:11027914] synonym: "corticotropin-releasing factor secretion" EXACT [] synonym: "CRF secretion" EXACT [] synonym: "CRH secretion" EXACT [] is_a: GO:0046879 ! hormone secretion [Term] id: GO:0043397 name: regulation of corticotropin-releasing hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion." [GOC:go_curators, PMID:11027914] synonym: "regulation of corticotropin-releasing factor secretion" EXACT [] synonym: "regulation of CRF secretion" EXACT [] synonym: "regulation of CRH secretion" EXACT [] is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0043396 ! corticotropin-releasing hormone secretion [Term] id: GO:0043398 name: HLH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization." [GOC:go_curators, Prosite:PDOC0038] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0043399 name: tRNA A64-2'-O-ribosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, PMID:7954819] synonym: "initiator tRNA phosphoribosyl-transferase activity" EXACT [] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0043400 name: cortisol secretion namespace: biological_process def: "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [PMID:11027914] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0043401 name: steroid hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724] synonym: "steroid hormone mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0071383 ! cellular response to steroid hormone stimulus [Term] id: GO:0043402 name: glucocorticoid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a glucocorticoid hormone." [PMID:15240347] synonym: "glucocorticoid mediated signalling" EXACT [] is_a: GO:0043401 ! steroid hormone mediated signaling pathway is_a: GO:0071385 ! cellular response to glucocorticoid stimulus [Term] id: GO:0043403 name: skeletal muscle tissue regeneration namespace: biological_process def: "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119] synonym: "myofiber turnover" RELATED [] is_a: GO:0042246 ! tissue regeneration [Term] id: GO:0043404 name: corticotropin-releasing hormone receptor activity namespace: molecular_function alt_id: GO:0031636 def: "Combining with corticotropin-releasing hormone to initiate a change in cell activity." [ISBN:0838577016, PMID:11027914, PMID:15134857] synonym: "adrenocorticotropin-releasing hormone receptor activity" EXACT [] synonym: "corticotropin-releasing factor receptor activity" EXACT [GOC:bf] synonym: "CRF receptor activity" EXACT [GOC:bf] synonym: "CRH receptor activity" EXACT [GOC:bf] is_a: GO:0004872 ! receptor activity is_a: GO:0051424 ! corticotropin-releasing hormone binding [Term] id: GO:0043405 name: regulation of MAP kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] synonym: "Regulation of MAPK activity" EXACT [GOC:dph] synonym: "regulation of mitogen activated protein kinase activity" EXACT [] synonym: "regulation of mitogen-activated protein kinase activity" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity [Term] id: GO:0043406 name: positive regulation of MAP kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] synonym: "positive regulation of mitogen activated protein kinase activity" EXACT [] synonym: "positive regulation of mitogen-activated protein kinase activity" EXACT [] synonym: "stimulation of MAPK activity" NARROW [] synonym: "up regulation of MAPK activity" EXACT [] synonym: "up-regulation of MAPK activity" EXACT [] synonym: "upregulation of MAPK activity" EXACT [] is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity [Term] id: GO:0043407 name: negative regulation of MAP kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] synonym: "down regulation of MAPK activity" EXACT [] synonym: "down-regulation of MAPK activity" EXACT [] synonym: "downregulation of MAPK activity" EXACT [] synonym: "inhibition of MAPK activity" NARROW [] synonym: "negative regulation of mitogen activated protein kinase activity" EXACT [] synonym: "negative regulation of mitogen-activated protein kinase activity" EXACT [] is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity [Term] id: GO:0043408 name: regulation of MAPKKK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators] synonym: "regulation of MAP kinase kinase kinase cascade" EXACT [] synonym: "regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] synonym: "regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] is_a: GO:0010627 ! regulation of intracellular protein kinase cascade relationship: regulates GO:0000165 ! MAPKKK cascade [Term] id: GO:0043409 name: negative regulation of MAPKKK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators] synonym: "down regulation of MAPKKK cascade" EXACT [] synonym: "down-regulation of MAPKKK cascade" EXACT [] synonym: "downregulation of MAPKKK cascade" EXACT [] synonym: "inhibition of MAPKKK cascade" NARROW [] synonym: "negative regulation of MAP kinase kinase kinase cascade" EXACT [] synonym: "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] synonym: "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] is_a: GO:0010741 ! negative regulation of intracellular protein kinase cascade is_a: GO:0043408 ! regulation of MAPKKK cascade relationship: negatively_regulates GO:0000165 ! MAPKKK cascade [Term] id: GO:0043410 name: positive regulation of MAPKKK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] synonym: "activation of MAPKKK cascade" NARROW [] synonym: "positive regulation of MAP kinase kinase kinase cascade" EXACT [] synonym: "positive regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] synonym: "positive regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] synonym: "stimulation of MAPKKK cascade" NARROW [] synonym: "up regulation of MAPKKK cascade" EXACT [] synonym: "up-regulation of MAPKKK cascade" EXACT [] synonym: "upregulation of MAPKKK cascade" EXACT [] is_a: GO:0010740 ! positive regulation of intracellular protein kinase cascade is_a: GO:0043408 ! regulation of MAPKKK cascade relationship: positively_regulates GO:0000165 ! MAPKKK cascade [Term] id: GO:0043411 name: myopalladin binding namespace: molecular_function def: "Interacting selectively and non-covalently with myopalladin, a myofibrillar protein with titin-like Ig domains." [GOC:go_curators] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0043412 name: macromolecule modification namespace: biological_process def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0043413 name: macromolecule glycosylation namespace: biological_process def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:jl] subset: gosubset_prok is_a: GO:0043412 ! macromolecule modification is_a: GO:0070085 ! glycosylation [Term] id: GO:0043414 name: macromolecule methylation namespace: biological_process def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators] subset: gosubset_prok is_a: GO:0032259 ! methylation is_a: GO:0043412 ! macromolecule modification is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0043415 name: positive regulation of skeletal muscle tissue regeneration namespace: biological_process def: "Any process that activates or increase the rate of skeletal muscle regeneration." [GOC:jl] synonym: "activation of skeletal muscle regeneration" NARROW [] synonym: "stimulation of skeletal muscle regeneration" NARROW [] synonym: "up regulation of skeletal muscle regeneration" EXACT [] synonym: "up-regulation of skeletal muscle regeneration" EXACT [] synonym: "upregulation of skeletal muscle regeneration" EXACT [] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0048639 ! positive regulation of developmental growth relationship: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0043416 name: regulation of skeletal muscle tissue regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061041 ! regulation of wound healing is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0043417 name: negative regulation of skeletal muscle tissue regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration." [GOC:jl] synonym: "down regulation of skeletal muscle regeneration" EXACT [] synonym: "down-regulation of skeletal muscle regeneration" EXACT [] synonym: "downregulation of skeletal muscle regeneration" EXACT [] synonym: "inhibition of skeletal muscle regeneration" NARROW [] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0048640 ! negative regulation of developmental growth relationship: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0043418 name: homocysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:jl] synonym: "homocysteine breakdown" EXACT [] synonym: "homocysteine catabolism" EXACT [] synonym: "homocysteine degradation" EXACT [] is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0050667 ! homocysteine metabolic process [Term] id: GO:0043419 name: urea catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl] synonym: "urea breakdown" EXACT [] synonym: "urea catabolism" EXACT [] synonym: "urea decomposition" EXACT [] synonym: "urea degradation" EXACT [] is_a: GO:0019627 ! urea metabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0043420 name: anthranilate metabolic process namespace: biological_process alt_id: GO:0018869 def: "The chemical reactions and pathways involving anthranilate (2-aminobenzoate)." [CHEBI:16567, GOC:jl] synonym: "2-aminobenzoate metabolic process" EXACT [] synonym: "2-aminobenzoate metabolism" EXACT [] synonym: "anthranilate metabolism" EXACT [] synonym: "anthranilic acid metabolic process" NARROW [] synonym: "anthranilic acid metabolism" NARROW [] synonym: "ortho-aminobenzoic acid metabolic process" NARROW [] synonym: "ortho-aminobenzoic acid metabolism" NARROW [] xref: UM-BBD_pathwayID:abz2 is_a: GO:0009308 ! amine metabolic process is_a: GO:0018874 ! benzoate metabolic process [Term] id: GO:0043421 name: anthranilate catabolic process namespace: biological_process alt_id: GO:0019259 def: "The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate)." [CHEBI:16567, GOC:jl] synonym: "2-aminobenzoate breakdown" EXACT [] synonym: "2-aminobenzoate catabolic process" EXACT [] synonym: "2-aminobenzoate catabolism" NARROW [] synonym: "2-aminobenzoate degradation" EXACT [] synonym: "anthranilate breakdown" EXACT [] synonym: "anthranilate catabolism" EXACT [] synonym: "anthranilate degradation" EXACT [] synonym: "anthranilic acid catabolic process" NARROW [] synonym: "anthranilic acid catabolism" NARROW [] synonym: "ortho-aminobenzoic acid catabolic process" NARROW [] synonym: "ortho-aminobenzoic acid catabolism" NARROW [] xref: MetaCyc:2AMINOBENZDEG-PWY is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043420 ! anthranilate metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0043422 name: protein kinase B binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism." [GOC:jl, http://www.heartandmetabolism.org/] synonym: "Akt binding" EXACT [] synonym: "PKB binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0043423 name: 3-phosphoinositide-dependent protein kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 3-phosphoinositide-dependent protein kinase." [GOC:jl] synonym: "phosphatidylinositol-3-phosphate-dependent protein kinase binding" EXACT [GOC:curators] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0043424 name: protein histidine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein histidine kinase." [GOC:jl] synonym: "histidine kinase binding" EXACT [] synonym: "histidine-protein kinase binding" EXACT [] synonym: "protein-histidine kinase binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0043425 name: bHLH transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0043426 name: MRF binding namespace: molecular_function def: "Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors." [PMID:10966875] is_a: GO:0043425 ! bHLH transcription factor binding [Term] id: GO:0043427 name: carbon fixation by 3-hydroxypropionate cycle namespace: biological_process def: "An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product." [GOC:jl, PMID:11418572, PMID:15838028] synonym: "3-hydroxypropionate cycle" EXACT [] synonym: "3-hydroxypropionate pathway" EXACT [] synonym: "hydroxypropionate cycle" EXACT [] synonym: "hydroxypropionate pathway" EXACT [] is_a: GO:0015977 ! carbon fixation [Term] id: GO:0043428 name: 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: MetaCyc:RXN-9227 is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043429 name: 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043430 name: 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043431 name: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838, PMID:1479344] synonym: "2-octaprenyl-6-hydroxy phenol methylase activity" EXACT [] synonym: "3-demethylubiquinone-9 3-methyltransferase activity" EXACT [] xref: MetaCyc:2.1.1.64-RXN is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0043433 name: negative regulation of sequence-specific DNA binding transcription factor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl] synonym: "down regulation of transcription factor activity" EXACT [] synonym: "down-regulation of transcription factor activity" EXACT [] synonym: "downregulation of transcription factor activity" EXACT [] synonym: "inhibition of transcription factor activity" NARROW [] synonym: "negative regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051090 ! regulation of sequence-specific DNA binding transcription factor activity [Term] id: GO:0043434 name: response to peptide hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] synonym: "response to polypeptide hormone stimulus" EXACT [] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0043435 name: response to corticotropin-releasing hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [PMID:11027914, PMID:15134857, Wikipedia:Corticotropin-releasing_hormone] synonym: "response to corticoliberin stimulus" EXACT [] synonym: "response to corticotropin-releasing factor stimulus" EXACT [] synonym: "response to CRF stimulus" EXACT [] synonym: "response to CRH stimulus" EXACT [] is_a: GO:0043434 ! response to peptide hormone stimulus [Term] id: GO:0043436 name: oxoacid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [CHEBI:24833] subset: gosubset_prok synonym: "keto acid metabolic process" EXACT [] synonym: "keto acid metabolism" EXACT [] synonym: "ketoacid metabolic process" EXACT [] synonym: "ketoacid metabolism" EXACT [] synonym: "oxo acid metabolic process" EXACT [] synonym: "oxo acid metabolism" EXACT [] synonym: "oxoacid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0043438 name: acetoacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH." [CHEBI:15344, Wikipedia:Acetoacetic_acid] synonym: "3-oxobutanoate metabolic process" EXACT [] synonym: "3-oxobutanoate metabolism" EXACT [] synonym: "3-oxobutanoic acid metabolic process" EXACT [] synonym: "3-oxobutanoic acid metabolism" EXACT [] synonym: "acetoacetate metabolic process" EXACT [] synonym: "acetoacetate metabolism" EXACT [] synonym: "acetoacetic acid metabolism" EXACT [] synonym: "beta ketobutyric acid metabolic process" EXACT [] synonym: "beta ketobutyric acid metabolism" EXACT [] synonym: "beta-ketobutyric acid metabolic process" EXACT [] synonym: "beta-ketobutyric acid metabolism" EXACT [] synonym: "diacetic acid metabolic process" EXACT [] synonym: "diacetic acid metabolism" EXACT [] is_a: GO:0019605 ! butyrate metabolic process [Term] id: GO:0043441 name: acetoacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl] synonym: "acetoacetic acid anabolism" EXACT [] synonym: "acetoacetic acid biosynthesis" EXACT [] synonym: "acetoacetic acid formation" EXACT [] synonym: "acetoacetic acid synthesis" EXACT [] xref: Reactome:1253005 "Formation of Acetoacetic Acid" xref: Reactome:1279935 "Formation of Acetoacetic Acid" xref: Reactome:1298831 "Formation of Acetoacetic Acid" xref: Reactome:1326509 "Formation of Acetoacetic Acid" xref: Reactome:1352616 "Formation of Acetoacetic Acid" xref: Reactome:1372847 "Formation of Acetoacetic Acid" xref: Reactome:1392860 "Formation of Acetoacetic Acid" xref: Reactome:1417335 "Formation of Acetoacetic Acid" xref: Reactome:1450424 "Formation of Acetoacetic Acid" xref: Reactome:1470955 "Formation of Acetoacetic Acid" xref: Reactome:1482991 "Formation of Acetoacetic Acid" xref: Reactome:1496765 "Formation of Acetoacetic Acid" xref: Reactome:1514155 "Formation of Acetoacetic Acid" xref: Reactome:1520981 "Formation of Acetoacetic Acid" xref: Reactome:1526734 "Formation of Acetoacetic Acid" xref: Reactome:1532457 "Formation of Acetoacetic Acid" xref: Reactome:1535998 "Formation of Acetoacetic Acid" xref: Reactome:1539256 "Formation of Acetoacetic Acid" xref: Reactome:1540305 "Formation of Acetoacetic Acid" xref: Reactome:77110 "Formation of Acetoacetic Acid" is_a: GO:0043438 ! acetoacetic acid metabolic process is_a: GO:0046358 ! butyrate biosynthetic process [Term] id: GO:0043442 name: acetoacetic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl] synonym: "acetoacetic acid breakdown" EXACT [] synonym: "acetoacetic acid catabolism" EXACT [] synonym: "acetoacetic acid degradation" EXACT [] is_a: GO:0043438 ! acetoacetic acid metabolic process is_a: GO:0046359 ! butyrate catabolic process [Term] id: GO:0043443 name: acetone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetone, propan-2-one." [GOC:jl] synonym: "2-propanone metabolic process" EXACT [] synonym: "2-propanone metabolism" EXACT [] synonym: "acetone metabolism" EXACT [] synonym: "dimethyl ketone metabolic process" EXACT [] synonym: "dimethyl ketone metabolism" EXACT [] synonym: "propan-2-one metabolic process" EXACT [] synonym: "propan-2-one metabolism" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0043444 name: acetone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one." [GOC:jl] synonym: "2-propanone catabolic process" EXACT [] synonym: "2-propanone catabolism" EXACT [] synonym: "acetone breakdown" EXACT [] synonym: "acetone catabolism" EXACT [] synonym: "acetone degradation" EXACT [] synonym: "dimethyl ketone catabolic process" EXACT [] synonym: "dimethyl ketone catabolism" EXACT [] synonym: "propan-2-one catabolic process" EXACT [] synonym: "propan-2-one catabolism" EXACT [] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0043443 ! acetone metabolic process [Term] id: GO:0043445 name: acetone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetone, propan-2-one." [GOC:jl] synonym: "2-propanone biosynthesis" EXACT [] synonym: "2-propanone biosynthetic process" EXACT [] synonym: "acetone anabolism" EXACT [] synonym: "acetone biosynthesis" EXACT [] synonym: "acetone formation" EXACT [] synonym: "acetone synthesis" EXACT [] synonym: "dimethyl ketone biosynthesis" EXACT [] synonym: "dimethyl ketone biosynthetic process" EXACT [] synonym: "propan-2-one biosynthesis" EXACT [] synonym: "propan-2-one biosynthetic process" EXACT [] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0043443 ! acetone metabolic process [Term] id: GO:0043446 name: cellular alkane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells." [CHEBI:18310, GOC:jl, Wikipedia:Alkane] subset: goslim_pir subset: gosubset_prok synonym: "alkane metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0043447 name: alkane biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [CHEBI:18310, GOC:jl, Wikipedia:Alkane] subset: gosubset_prok synonym: "alkane anabolism" EXACT [] synonym: "alkane biosynthesis" EXACT [] synonym: "alkane formation" EXACT [] synonym: "alkane synthesis" EXACT [] is_a: GO:0043446 ! cellular alkane metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0043448 name: alkane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [CHEBI:18310, GOC:jl, Wikipedia:Alkane] subset: gosubset_prok synonym: "alkane breakdown" EXACT [] synonym: "alkane catabolism" EXACT [] synonym: "alkane degradation" EXACT [] is_a: GO:0043446 ! cellular alkane metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0043449 name: cellular alkene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells." [CHEBI:32878, GOC:jl, Wikipedia:Alkene] subset: goslim_pir subset: gosubset_prok synonym: "alkene metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0043450 name: alkene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [CHEBI:32878, GOC:jl, Wikipedia:Alkene] subset: gosubset_prok synonym: "alkene anabolism" EXACT [] synonym: "alkene biosynthesis" EXACT [] synonym: "alkene formation" EXACT [] synonym: "alkene synthesis" EXACT [] is_a: GO:0043449 ! cellular alkene metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0043451 name: alkene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [CHEBI:32878, GOC:jl, Wikipedia:Alkene] subset: gosubset_prok synonym: "alkene breakdown" EXACT [] synonym: "alkene catabolism" EXACT [] synonym: "alkene degradation" EXACT [] is_a: GO:0043449 ! cellular alkene metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0043452 name: cellular alkyne metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne] subset: goslim_pir subset: gosubset_prok synonym: "alkyne metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0043453 name: alkyne biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne] synonym: "alkyne anabolism" EXACT [] synonym: "alkyne biosynthesis" EXACT [] synonym: "alkyne formation" EXACT [] synonym: "alkyne synthesis" EXACT [] is_a: GO:0043452 ! cellular alkyne metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0043454 name: alkyne catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alkyne, any cyclic branched or unbranched hydrocarbons having a carbon-carbon triple bond and the general formula CnH2n-2." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne] subset: gosubset_prok synonym: "alkyne breakdown" EXACT [] synonym: "alkyne catabolism" EXACT [] synonym: "alkyne degradation" EXACT [] is_a: GO:0043452 ! cellular alkyne metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0043455 name: regulation of secondary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] synonym: "regulation of secondary metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0019748 ! secondary metabolic process [Term] id: GO:0043456 name: regulation of pentose-phosphate shunt namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis." [GOC:jl] synonym: "regulation of pentose phosphate pathway" EXACT [] synonym: "regulation of pentose phosphate shunt" EXACT [] synonym: "regulation of pentose-phosphate pathway" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process relationship: regulates GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0043457 name: regulation of cellular respiration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl] is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy relationship: regulates GO:0045333 ! cellular respiration [Term] id: GO:0043458 name: ethanol biosynthetic process involved in glucose fermentation to ethanol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP." [GOC:dph, GOC:jl, GOC:tb] synonym: "ethanol anabolism during fermentation" RELATED [] synonym: "ethanol formation during fermentation" RELATED [] synonym: "ethanol synthesis during fermentation" RELATED [] is_a: GO:0006115 ! ethanol biosynthetic process relationship: part_of GO:0019655 ! glucose catabolic process to ethanol [Term] id: GO:0043459 name: response to short exposure to lithium ion namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus." [PMID:10208444] comment: This term was made obsolete because 'short' is not a quantitative or meaningful measurement of time. is_obsolete: true [Term] id: GO:0043460 name: response to long exposure to lithium ion namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus." [PMID:10208444] comment: This term was made obsolete because 'long' is not a quantitative or meaningful measurement of time. is_obsolete: true [Term] id: GO:0043461 name: proton-transporting ATP synthase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/] subset: gosubset_prok synonym: "F-type ATPase complex assembly" EXACT [] is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly relationship: part_of GO:0070272 ! proton-transporting ATP synthase complex biogenesis [Term] id: GO:0043462 name: regulation of ATPase activity namespace: biological_process def: "Any process that modulates the rate of ATP hydrolysis by an ATPase." [GOC:jl] synonym: "regulation of adenosinetriphosphatase activity" EXACT [] is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0043463 name: regulation of rhamnose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [GOC:jl] synonym: "regulation of rhamnose breakdown" EXACT [] synonym: "regulation of rhamnose catabolism" EXACT [] synonym: "regulation of rhamnose degradation" EXACT [] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process relationship: regulates GO:0019301 ! rhamnose catabolic process [Term] id: GO:0043464 name: malolactic fermentation namespace: biological_process def: "The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP." [PMID:10427020, PMID:8808948] synonym: "L-malate fermentation" BROAD [] synonym: "malate fermentation" BROAD [] synonym: "malo-lactate fermentation" EXACT [] synonym: "malolactate fermentation" EXACT [] xref: Wikipedia:Malolactic_fermentation is_a: GO:0006113 ! fermentation [Term] id: GO:0043465 name: regulation of fermentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP)." [GOC:jl] is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy relationship: regulates GO:0006113 ! fermentation [Term] id: GO:0043466 name: pyrimidine base fermentation namespace: biological_process def: "The anaerobic conversion of pyrimidine bases, yielding energy in the form of ATP." [CHEBI:26432, GOC:jl] synonym: "pyrimidine fermentation" RELATED [GOC:curators] synonym: "pyrimidine nucleobase fermentation" EXACT [CHEBI:26432] is_a: GO:0006208 ! pyrimidine base catabolic process is_a: GO:0019666 ! nitrogenous compound fermentation [Term] id: GO:0043467 name: regulation of generation of precursor metabolites and energy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0006091 ! generation of precursor metabolites and energy [Term] id: GO:0043468 name: regulation of fucose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose." [GOC:mlg] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process relationship: regulates GO:0019317 ! fucose catabolic process [Term] id: GO:0043469 name: regulation of D-xylose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose." [GOC:mlg] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process relationship: regulates GO:0042843 ! D-xylose catabolic process [Term] id: GO:0043470 name: regulation of carbohydrate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg] subset: gosubset_prok is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009894 ! regulation of catabolic process relationship: regulates GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0043471 name: regulation of cellular carbohydrate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells." [GOC:jl] subset: gosubset_prok is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0043472 name: IgD binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of a D isotype." [PMID:12886015] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in an organism, tissue or cell." [GOC:jl] subset: goslim_generic subset: goslim_pir subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0043474 name: pigment metabolic process involved in pigmentation namespace: biological_process def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:dph, GOC:jl, GOC:tb] synonym: "pigment metabolic process during pigmentation" RELATED [GOC:dph, GOC:tb] synonym: "pigment metabolism during pigmentation" RELATED [] is_a: GO:0042440 ! pigment metabolic process relationship: part_of GO:0043473 ! pigmentation [Term] id: GO:0043475 name: pigment metabolic process involved in pigment accumulation namespace: biological_process def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, as part of the accumulation of pigment." [GOC:jl] synonym: "pigment metabolic process during pigment accumulation" RELATED [GOC:dph, GOC:tb] synonym: "pigment metabolism during pigment accumulation" RELATED [] is_a: GO:0043474 ! pigment metabolic process involved in pigmentation relationship: part_of GO:0043476 ! pigment accumulation [Term] id: GO:0043476 name: pigment accumulation namespace: biological_process def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl] synonym: "pigment accumulation in response to external stimulus" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0043473 ! pigmentation [Term] id: GO:0043477 name: pigment biosynthetic process involved in pigment accumulation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, resulting in pigment accumulation." [GOC:dph, GOC:jl, GOC:tb] synonym: "pigment biosynthetic process during pigment accumulation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043475 ! pigment metabolic process involved in pigment accumulation is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0043478 name: pigment accumulation in response to UV light namespace: biological_process def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus." [GOC:jl] is_a: GO:0009411 ! response to UV is_a: GO:0043476 ! pigment accumulation [Term] id: GO:0043479 name: pigment accumulation in tissues in response to UV light namespace: biological_process def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl] is_a: GO:0043478 ! pigment accumulation in response to UV light is_a: GO:0043480 ! pigment accumulation in tissues [Term] id: GO:0043480 name: pigment accumulation in tissues namespace: biological_process def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus." [GOC:jl] synonym: "organismal pigment accumulation" EXACT [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0043476 ! pigment accumulation [Term] id: GO:0043481 name: anthocyanin accumulation in tissues in response to UV light namespace: biological_process def: "The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl] is_a: GO:0043479 ! pigment accumulation in tissues in response to UV light [Term] id: GO:0043482 name: cellular pigment accumulation namespace: biological_process def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl] subset: gosubset_prok is_a: GO:0033059 ! cellular pigmentation is_a: GO:0043476 ! pigment accumulation is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0043483 name: anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus." [GOC:dph, GOC:jl, GOC:tb] synonym: "anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED [] synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light" RELATED [GOC:dph, GOC:tb] synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED [] is_a: GO:0009718 ! anthocyanin biosynthetic process is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation relationship: part_of GO:0043481 ! anthocyanin accumulation in tissues in response to UV light [Term] id: GO:0043484 name: regulation of RNA splicing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0008380 ! RNA splicing [Term] id: GO:0043485 name: endosome to pigment granule transport namespace: biological_process def: "The directed movement of substances from endosomes to pigment granules." [GOC:jl] is_a: GO:0016197 ! endosome transport relationship: part_of GO:0048757 ! pigment granule maturation [Term] id: GO:0043486 name: histone exchange namespace: biological_process def: "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277] comment: Note that this term also includes the exchange of sperm-specific histones or protamines with histones, occurring during spermatogenesis and fertilization. synonym: "histone chaperone" RELATED [GOC:vw] synonym: "histone displacement" EXACT [] synonym: "histone replacement" EXACT [] is_a: GO:0034728 ! nucleosome organization is_a: GO:0043044 ! ATP-dependent chromatin remodeling [Term] id: GO:0043487 name: regulation of RNA stability namespace: biological_process def: "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] subset: gosubset_prok is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0051252 ! regulation of RNA metabolic process [Term] id: GO:0043488 name: regulation of mRNA stability namespace: biological_process def: "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] subset: gosubset_prok is_a: GO:0016071 ! mRNA metabolic process is_a: GO:0043487 ! regulation of RNA stability [Term] id: GO:0043489 name: RNA stabilization namespace: biological_process def: "Prevention of degradation of RNA molecules." [GOC:go_curators] subset: gosubset_prok is_a: GO:0043487 ! regulation of RNA stability [Term] id: GO:0043490 name: malate-aspartate shuttle namespace: biological_process def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663] synonym: "malate aspartate shuttle" EXACT [] synonym: "malate/aspartate shuttle" EXACT [] synonym: "malate:aspartate shuttle" EXACT [] xref: Wikipedia:Malate-aspartate_shuttle is_a: GO:0006839 ! mitochondrial transport relationship: part_of GO:0022904 ! respiratory electron transport chain [Term] id: GO:0043491 name: protein kinase B signaling cascade namespace: biological_process def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound." [GOC:bf] synonym: "AKT signaling cascade" EXACT [] synonym: "AKT signalling cascade" EXACT [] synonym: "PKB signaling cascade" EXACT [] synonym: "PKB signalling cascade" EXACT [] synonym: "protein kinase B signalling cascade" EXACT [] is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0043492 name: ATPase activity, coupled to movement of substances namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl] subset: gosubset_prok is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0043493 name: phage terminase complex namespace: cellular_component def: "A complex of a large and small subunit which catalyze the packaging of DNA into phage heads. Note that not all phage terminases have this structure, some exist as single polypeptides." [GOC:mlg] is_a: GO:0033655 ! host cell cytoplasm part is_a: GO:0043234 ! protein complex [Term] id: GO:0043494 name: CLRC ubiquitin ligase complex namespace: cellular_component def: "An active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation." [GOC:vw, PMID:16127433, PMID:20211136] synonym: "Clr4-Rik1-Cul4 complex" EXACT [] synonym: "CLRC complex" EXACT [] synonym: "Rik1 E3 ubiquitin ligase complex" EXACT [] synonym: "Rik1-E3 ubiquitin ligase complex" EXACT [] is_a: GO:0031465 ! Cul4B-RING ubiquitin ligase complex [Term] id: GO:0043495 name: protein anchor namespace: molecular_function def: "Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane." [GOC:go_curators] synonym: "anchoring" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0043496 name: regulation of protein homodimerization activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:jl, GOC:tb] comment: Note that protein homodimerization is a molecular function: 'protein homodimerization activity ; GO:0042803'. is_a: GO:0043393 ! regulation of protein binding [Term] id: GO:0043497 name: regulation of protein heterodimerization activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer." [GOC:jl, GOC:tb] comment: Note that protein heterodimerization is a molecular function: 'protein heterodimerization activity ; GO:0046982'. is_a: GO:0043393 ! regulation of protein binding [Term] id: GO:0043498 name: cell surface binding namespace: molecular_function def: "Interacting selectively and non-covalently with any component on the surface of a cell." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0043499 name: eukaryotic cell surface binding namespace: molecular_function def: "Interacting selectively and non-covalently with any component on the surface of a eukaryotic cell." [GOC:jl] is_a: GO:0043498 ! cell surface binding [Term] id: GO:0043500 name: muscle adaptation namespace: biological_process def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] subset: goslim_pir synonym: "muscle plasticity" RELATED [] is_a: GO:0003012 ! muscle system process [Term] id: GO:0043501 name: skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] synonym: "skeletal muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation [Term] id: GO:0043502 name: regulation of muscle adaptation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle] synonym: "regulation of muscle plasticity" RELATED [] is_a: GO:0090257 ! regulation of muscle system process relationship: regulates GO:0043500 ! muscle adaptation [Term] id: GO:0043503 name: skeletal muscle fiber adaptation namespace: biological_process def: "Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] synonym: "skeletal muscle fiber plasticity" RELATED [] synonym: "skeletal muscle fibre plasticity" EXACT [] synonym: "skeletal myofiber plasticity" EXACT [] synonym: "skeletal myofibre plasticity" EXACT [] is_a: GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0043504 name: mitochondrial DNA repair namespace: biological_process def: "The process of restoring mitochondrial DNA after damage." [PMID:12565799, PMID:15189144, PMID:16050976] is_a: GO:0006281 ! DNA repair is_a: GO:0032042 ! mitochondrial DNA metabolic process [Term] id: GO:0043505 name: centromere-specific nucleosome namespace: cellular_component def: "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641] synonym: "centromere specific nucleosome" EXACT [] synonym: "centromeric nucleosome" EXACT [] is_a: GO:0000786 ! nucleosome relationship: part_of GO:0000939 ! condensed chromosome inner kinetochore [Term] id: GO:0043506 name: regulation of JUN kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl] synonym: "regulation of JUNK activity" EXACT [] is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0046328 ! regulation of JNK cascade [Term] id: GO:0043507 name: positive regulation of JUN kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl] synonym: "positive regulation of JUNK activity" EXACT [] synonym: "stimulation of JNK activity" NARROW [] synonym: "up regulation of JNK activity" EXACT [] synonym: "up-regulation of JNK activity" EXACT [] synonym: "upregulation of JNK activity" EXACT [] is_a: GO:0043406 ! positive regulation of MAP kinase activity is_a: GO:0043506 ! regulation of JUN kinase activity [Term] id: GO:0043508 name: negative regulation of JUN kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl] synonym: "down regulation of JNK activity" EXACT [] synonym: "down-regulation of JNK activity" EXACT [] synonym: "downregulation of JNK activity" EXACT [] synonym: "inhibition of JNK activity" NARROW [] synonym: "negative regulation of JUNK activity" EXACT [] is_a: GO:0043407 ! negative regulation of MAP kinase activity is_a: GO:0043506 ! regulation of JUN kinase activity [Term] id: GO:0043509 name: activin A complex namespace: cellular_component alt_id: GO:0048181 def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'. is_a: GO:0048180 ! activin complex [Term] id: GO:0043510 name: activin B complex namespace: cellular_component alt_id: GO:0048182 def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. is_a: GO:0048180 ! activin complex [Term] id: GO:0043511 name: inhibin complex namespace: cellular_component def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl] comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0043512 name: inhibin A complex namespace: cellular_component def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl] comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. is_a: GO:0043511 ! inhibin complex [Term] id: GO:0043513 name: inhibin B complex namespace: cellular_component def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl] comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. is_a: GO:0043511 ! inhibin complex [Term] id: GO:0043514 name: interleukin-12 complex namespace: cellular_component def: "A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space." [GOC:add, GOC:ebc, GOC:mah, PMID:12948519, PMID:1381512] comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain. synonym: "IL-12 complex" EXACT [GOC:mah] synonym: "IL12A" NARROW [GOC:add] synonym: "IL12B" NARROW [GOC:add] synonym: "p35" NARROW [GOC:add] synonym: "p40" NARROW [GOC:add] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0043515 name: kinetochore binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl, http://www.mercksource.com/] is_a: GO:0005488 ! binding [Term] id: GO:0043516 name: regulation of DNA damage response, signal transduction by p53 class mediator namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] synonym: "regulation of p53 induced by DNA damage response" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator [Term] id: GO:0043517 name: positive regulation of DNA damage response, signal transduction by p53 class mediator namespace: biological_process def: "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] synonym: "activation of DNA damage response, signal transduction by p53 class mediator" NARROW [] synonym: "positive regulation of p53 induced by DNA damage response" EXACT [] synonym: "stimulation of DNA damage response, signal transduction by p53 class mediator" NARROW [] synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator relationship: positively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator [Term] id: GO:0043518 name: negative regulation of DNA damage response, signal transduction by p53 class mediator namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator" NARROW [] synonym: "negative regulation of p53 induced by DNA damage response" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator relationship: negatively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator [Term] id: GO:0043519 name: regulation of myosin II filament organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl] synonym: "regulation of myosin II filament assembly or disassembly" RELATED [GOC:mah] is_a: GO:0032956 ! regulation of actin cytoskeleton organization relationship: regulates GO:0031038 ! myosin II filament organization [Term] id: GO:0043520 name: regulation of myosin II filament assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules." [GOC:jl] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0043519 ! regulation of myosin II filament organization relationship: regulates GO:0031036 ! myosin II filament assembly [Term] id: GO:0043521 name: regulation of myosin II filament disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl] is_a: GO:0043244 ! regulation of protein complex disassembly is_a: GO:0043519 ! regulation of myosin II filament organization relationship: regulates GO:0031037 ! myosin II filament disassembly [Term] id: GO:0043522 name: leucine zipper domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns." [GOC:jl, InterPro:IPR002158] synonym: "leucine zipper binding" EXACT [] is_a: GO:0030275 ! LRR domain binding [Term] id: GO:0043523 name: regulation of neuron apoptosis namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptosis in neurons." [GOC:go_curators] synonym: "regulation of apoptosis of neuronal cells" EXACT [] synonym: "regulation of apoptosis of neurons" EXACT [] synonym: "regulation of neuron programmed cell death" EXACT [] synonym: "regulation of neuronal cell programmed cell death" EXACT [] synonym: "regulation of programmed cell death of neuronal cells" EXACT [] synonym: "regulation of programmed cell death, neurons" EXACT [] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0051402 ! neuron apoptosis [Term] id: GO:0043524 name: negative regulation of neuron apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptosis in neurons." [GOC:go_curators] synonym: "down regulation of neuron apoptosis" EXACT [] synonym: "down-regulation of neuron apoptosis" EXACT [] synonym: "downregulation of neuron apoptosis" EXACT [] synonym: "inhibition of neuron apoptosis" NARROW [] synonym: "negative regulation of programmed cell death, neurons" EXACT [] synonym: "neuron survival" NARROW [] is_a: GO:0043066 ! negative regulation of apoptosis is_a: GO:0043523 ! regulation of neuron apoptosis relationship: negatively_regulates GO:0051402 ! neuron apoptosis [Term] id: GO:0043525 name: positive regulation of neuron apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptosis." [GOC:go_curators] synonym: "activation of neuron apoptosis" NARROW [] synonym: "positive regulation of programmed cell death, neurons" EXACT [] synonym: "stimulation of neuron apoptosis" NARROW [] synonym: "up regulation of neuron apoptosis" EXACT [] synonym: "up-regulation of neuron apoptosis" EXACT [] synonym: "upregulation of neuron apoptosis" EXACT [] is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:0043523 ! regulation of neuron apoptosis relationship: positively_regulates GO:0051402 ! neuron apoptosis [Term] id: GO:0043526 name: neuroprotection namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss." [MeSH:G04.335.139.160, PMID:10208444, PMID:11909981, PMID:15905876] xref: Wikipedia:Neuroprotection is_a: GO:0043523 ! regulation of neuron apoptosis [Term] id: GO:0043527 name: tRNA methyltransferase complex namespace: cellular_component def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0034708 ! methyltransferase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0043528 name: tRNA (m2G10) methyltransferase complex namespace: cellular_component def: "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842] is_a: GO:0043527 ! tRNA methyltransferase complex [Term] id: GO:0043529 name: GET complex namespace: cellular_component def: "A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins." [PMID:16269340] synonym: "Golgi to ER Traffic complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0043530 name: adenosine 5'-monophosphoramidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 5'-monophosphoramidate = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." [PMID:11805111] synonym: "adenosine 5' monophosphoramidase activity" EXACT [] synonym: "adenosine 5'-monophosphoramidate hydrolase activity" EXACT [] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043531 name: ADP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate." [GOC:jl] synonym: "adenosine 5'-diphosphate binding" EXACT [] synonym: "adenosine diphosphate binding" EXACT [] is_a: GO:0032559 ! adenyl ribonucleotide binding [Term] id: GO:0043532 name: angiostatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488] is_a: GO:0005515 ! protein binding [Term] id: GO:0043533 name: inositol 1,3,4,5 tetrakisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "InsP4 binding" EXACT [] synonym: "IP4 binding" EXACT [] is_a: GO:0043178 ! alcohol binding [Term] id: GO:0043534 name: blood vessel endothelial cell migration namespace: biological_process def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264] is_a: GO:0043542 ! endothelial cell migration [Term] id: GO:0043535 name: regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] is_a: GO:0010594 ! regulation of endothelial cell migration relationship: regulates GO:0043534 ! blood vessel endothelial cell migration [Term] id: GO:0043536 name: positive regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] synonym: "activation of blood vessel endothelial cell migration" NARROW [] synonym: "stimulation of blood vessel endothelial cell migration" NARROW [] synonym: "up regulation of blood vessel endothelial cell migration" EXACT [] synonym: "up-regulation of blood vessel endothelial cell migration" EXACT [] synonym: "upregulation of blood vessel endothelial cell migration" EXACT [] is_a: GO:0010595 ! positive regulation of endothelial cell migration is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration relationship: positively_regulates GO:0043534 ! blood vessel endothelial cell migration [Term] id: GO:0043537 name: negative regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] synonym: "down regulation of blood vessel endothelial cell migration" EXACT [] synonym: "down-regulation of blood vessel endothelial cell migration" EXACT [] synonym: "downregulation of blood vessel endothelial cell migration" EXACT [] synonym: "inhibition of blood vessel endothelial cell migration" NARROW [] is_a: GO:0010596 ! negative regulation of endothelial cell migration is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration relationship: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration [Term] id: GO:0043538 name: regulation of actin phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule." [GOC:go_curators] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0032956 ! regulation of actin cytoskeleton organization relationship: regulates GO:0031289 ! actin phosphorylation [Term] id: GO:0043539 name: protein serine/threonine kinase activator activity namespace: molecular_function def: "Increases the activity of a protein serine/threonine kinase." [GOC:go_curators] synonym: "protein ser/thr kinase activator activity" EXACT [] is_a: GO:0030295 ! protein kinase activator activity [Term] id: GO:0043540 name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex namespace: cellular_component def: "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, GOC:so] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0043541 name: UDP-N-acetylglucosamine transferase complex namespace: cellular_component def: "A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis." [GOC:rn, PMID:19129246] comment: See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'. is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0043542 name: endothelial cell migration namespace: biological_process def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators] is_a: GO:0016477 ! cell migration [Term] id: GO:0043543 name: protein acylation namespace: biological_process def: "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl] subset: gosubset_prok synonym: "protein amino acid acylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0043544 name: lipoamide binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators] is_a: GO:0031405 ! lipoic acid binding [Term] id: GO:0043545 name: molybdopterin cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] subset: gosubset_prok synonym: "Moco metabolic process" EXACT [] synonym: "Moco metabolism" EXACT [] synonym: "molybdopterin cofactor metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process is_a: GO:0051189 ! prosthetic group metabolic process [Term] id: GO:0043546 name: molybdopterin cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] synonym: "Moco binding" EXACT [] is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0043547 name: positive regulation of GTPase activity namespace: biological_process def: "Any process that activates or increases the activity of a GTPase." [GOC:jl] synonym: "activation of GTPase activity" NARROW [] synonym: "stimulation of GTPase activity" NARROW [] synonym: "up regulation of GTPase activity" EXACT [] synonym: "up-regulation of GTPase activity" EXACT [] synonym: "upregulation of GTPase activity" EXACT [] is_a: GO:0043087 ! regulation of GTPase activity is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0043548 name: phosphatidylinositol 3-kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069] synonym: "phosphoinositide 3-kinase binding" EXACT [GOC:curators] synonym: "PI3K binding" EXACT [] is_a: GO:0019900 ! kinase binding [Term] id: GO:0043549 name: regulation of kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] subset: gosubset_prok is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0051338 ! regulation of transferase activity [Term] id: GO:0043550 name: regulation of lipid kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] subset: gosubset_prok is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0043549 ! regulation of kinase activity [Term] id: GO:0043551 name: regulation of phosphatidylinositol 3-kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf] synonym: "regulation of phosphoinositide 3-kinase activity" EXACT [GOC:curators] is_a: GO:0043550 ! regulation of lipid kinase activity [Term] id: GO:0043552 name: positive regulation of phosphatidylinositol 3-kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf] synonym: "activation of phosphatidylinositol 3-kinase activity" NARROW [] synonym: "positive regulation of phosphoinositide 3-kinase activity" EXACT [GOC:curators] synonym: "stimulation of phosphatidylinositol 3-kinase activity" NARROW [] synonym: "up regulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "up-regulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "upregulation of phosphatidylinositol 3-kinase activity" EXACT [] is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity is_a: GO:0090218 ! positive regulation of lipid kinase activity [Term] id: GO:0043553 name: negative regulation of phosphatidylinositol 3-kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf] synonym: "down regulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "down-regulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "downregulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "inhibition of phosphatidylinositol 3-kinase activity" NARROW [] synonym: "negative regulation of phosphoinositide 3-kinase activity" EXACT [GOC:curators] synonym: "negative regulation of PI3K activity" EXACT [GOC:bf] is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity is_a: GO:0090219 ! negative regulation of lipid kinase activity [Term] id: GO:0043554 name: aerobic respiration, using arsenite as electron donor namespace: biological_process def: "The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems." [GOC:mlg] is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0043555 name: regulation of translation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] synonym: "translational stress response" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0043556 name: regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] is_a: GO:0034599 ! cellular response to oxidative stress is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0043557 name: regulation of translation in response to osmotic stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] is_a: GO:0006970 ! response to osmotic stress is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0043558 name: regulation of translational initiation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl] synonym: "regulation of translation initiation in response to stress" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0043559 name: insulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0017046 ! peptide hormone binding [Term] id: GO:0043560 name: insulin receptor substrate binding namespace: molecular_function def: "Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex." [PMID:12829233] synonym: "insulin receptor substrate [protein] binding" EXACT [] synonym: "IRS [protein] binding" EXACT [] synonym: "IRS binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0043561 name: regulation of translational initiation in response to osmotic stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, GOC:jl, GOC:tb] is_a: GO:0043557 ! regulation of translation in response to osmotic stress is_a: GO:0043558 ! regulation of translational initiation in response to stress [Term] id: GO:0043562 name: cellular response to nitrogen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen." [GOC:jl] subset: gosubset_prok is_a: GO:0031669 ! cellular response to nutrient levels [Term] id: GO:0043563 name: odorant transporter activity namespace: molecular_function def: "Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of or within a cell, or between cells." [GOC:jl] subset: gosubset_prok is_a: GO:0005215 ! transporter activity [Term] id: GO:0043564 name: Ku70:Ku80 complex namespace: cellular_component def: "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983] synonym: "Ku70:Ku80 heterodimer" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0043565 name: sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] subset: gosubset_prok synonym: "sequence specific DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0043566 name: structure-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding." [GOC:jl] subset: gosubset_prok synonym: "structure specific DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0043567 name: regulation of insulin-like growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] synonym: "regulation of IGF receptor signaling pathway" EXACT [] synonym: "regulation of IGF receptor signalling pathway" EXACT [] synonym: "regulation of insulin-like growth factor receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway [Term] id: GO:0043568 name: positive regulation of insulin-like growth factor receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] synonym: "activation of insulin-like growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of IGF receptor signaling pathway" EXACT [] synonym: "positive regulation of IGF receptor signalling pathway" EXACT [] synonym: "positive regulation of insulin-like growth factor receptor signalling pathway" EXACT [] synonym: "stimulation of insulin-like growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of insulin-like growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway relationship: positively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway [Term] id: GO:0043569 name: negative regulation of insulin-like growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] synonym: "down regulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of insulin-like growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of IGF receptor signaling pathway" EXACT [] synonym: "negative regulation of IGF receptor signalling pathway" EXACT [] synonym: "negative regulation of insulin-like growth factor receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway relationship: negatively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway [Term] id: GO:0043570 name: maintenance of DNA repeat elements namespace: biological_process def: "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0051276 ! chromosome organization [Term] id: GO:0043571 name: maintenance of CRISPR repeat elements namespace: biological_process def: "Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences." [PMID:16292354] synonym: "CRISPR element metabolic process" RELATED [] synonym: "CRISPR element metabolism" RELATED [] synonym: "maintenance of clustered regularly interspaced short palindromic repeat elements" EXACT [] is_a: GO:0043570 ! maintenance of DNA repeat elements [Term] id: GO:0043572 name: plastid fission namespace: biological_process def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl] is_a: GO:0048285 ! organelle fission [Term] id: GO:0043573 name: leucoplast fission namespace: biological_process def: "The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jl] is_a: GO:0043572 ! plastid fission [Term] id: GO:0043574 name: peroxisomal transport namespace: biological_process def: "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl] is_a: GO:0046907 ! intracellular transport [Term] id: GO:0043575 name: detection of osmotic stimulus namespace: biological_process def: "The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal." [GOC:jl] is_a: GO:0006970 ! response to osmotic stress is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0043576 name: regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0007585 ! respiratory gaseous exchange [Term] id: GO:0043577 name: chemotropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it." [GOC:jl, PMID:10087613] xref: Wikipedia:Chemotropism is_a: GO:0009606 ! tropism is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0043578 name: nuclear matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane." [GOC:dph, GOC:jl, GOC:mah] synonym: "nuclear matrix organisation" EXACT [GOC:curators] synonym: "nuclear matrix organization and biogenesis" RELATED [GOC:mah] synonym: "nucleoskeleton organization" EXACT [GOC:tb] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0043579 name: elaioplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored." [GOC:jl] synonym: "elaioplast organisation" EXACT [GOC:curators] synonym: "elaioplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0043580 name: periplasmic space organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi." [GOC:dph, GOC:jl, GOC:mah] subset: gosubset_prok synonym: "periplasmic space organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0043581 name: mycelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium is the mass of hyphae that constitutes the vegetative part of a fungus." [GOC:jl, ISBN:1580085792] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0043582 name: sporangium development namespace: biological_process def: "The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores." [GOC:jl, Wikipedia:Sporagium] synonym: "sporangia development" EXACT [] is_a: GO:0075259 ! spore-bearing organ development [Term] id: GO:0043583 name: ear development namespace: biological_process def: "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] synonym: "hearing organ development" EXACT [] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0043584 name: nose development namespace: biological_process def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/] synonym: "nasus development" EXACT [] is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0043585 name: nose morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/] synonym: "nasus morphogenesis" EXACT [] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0043584 ! nose development [Term] id: GO:0043586 name: tongue development namespace: biological_process def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] synonym: "glossa development" NARROW [] synonym: "lingua development" NARROW [] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0043587 name: tongue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] synonym: "glossa morphogenesis" NARROW [] synonym: "lingua morphogenesis" EXACT [] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0043586 ! tongue development [Term] id: GO:0043588 name: skin development namespace: biological_process def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] synonym: "animal skin development" EXACT [] is_a: GO:0008544 ! epidermis development [Term] id: GO:0043589 name: skin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] is_a: GO:0048730 ! epidermis morphogenesis relationship: part_of GO:0043588 ! skin development [Term] id: GO:0043590 name: bacterial nucleoid namespace: cellular_component def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl] subset: gosubset_prok is_a: GO:0009295 ! nucleoid [Term] id: GO:0043591 name: endospore external encapsulating structure namespace: cellular_component alt_id: GO:0055030 def: "The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:go_curators, PMID:15035041] subset: goslim_pir synonym: "endospore wall" EXACT [GOC:mah] synonym: "peptidoglycan-based spore wall" EXACT [GOC:mtg_sensu] synonym: "spore wall" BROAD [GOC:mtg_sensu] is_a: GO:0031160 ! spore wall [Term] id: GO:0043592 name: exosporium namespace: cellular_component def: "The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg] subset: gosubset_prok synonym: "epispore" RELATED [] synonym: "exospore" RELATED [] synonym: "perispore" RELATED [] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0043591 ! endospore external encapsulating structure [Term] id: GO:0043593 name: endospore coat namespace: cellular_component def: "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg] subset: gosubset_prok is_a: GO:0044426 ! cell wall part relationship: part_of GO:0043591 ! endospore external encapsulating structure [Term] id: GO:0043594 name: outer endospore membrane namespace: cellular_component def: "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg] subset: gosubset_prok is_a: GO:0019867 ! outer membrane is_a: GO:0044426 ! cell wall part relationship: part_of GO:0043591 ! endospore external encapsulating structure [Term] id: GO:0043595 name: endospore cortex namespace: cellular_component def: "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg] subset: gosubset_prok is_a: GO:0044426 ! cell wall part relationship: part_of GO:0043591 ! endospore external encapsulating structure [Term] id: GO:0043596 name: nuclear replication fork namespace: cellular_component def: "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] is_a: GO:0005657 ! replication fork is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0043597 name: cytoplasmic replication fork namespace: cellular_component def: "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] is_a: GO:0005657 ! replication fork is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0043598 name: cytoplasmic DNA replication factor C complex namespace: cellular_component def: "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species." [GOC:mtg_sensu, PMID:14646196, PMID:16172520] is_a: GO:0005663 ! DNA replication factor C complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0043600 ! cytoplasmic replisome [Term] id: GO:0043599 name: nuclear DNA replication factor C complex namespace: cellular_component def: "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species." [GOC:mtg_sensu, PMID:14614842] is_a: GO:0005663 ! DNA replication factor C complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0043600 name: cytoplasmic replisome namespace: cellular_component def: "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins." [GOC:jl, GOC:mtg_sensu] is_a: GO:0030894 ! replisome is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0043597 ! cytoplasmic replication fork [Term] id: GO:0043601 name: nuclear replisome namespace: cellular_component def: "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] is_a: GO:0030894 ! replisome is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043596 ! nuclear replication fork [Term] id: GO:0043602 name: nitrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl] synonym: "nitrate disassimilation" EXACT [] synonym: "nitrate dissimilation" EXACT [] is_a: GO:0042126 ! nitrate metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0043603 name: cellular amide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [CHEBI:32988] subset: goslim_pir subset: gosubset_prok synonym: "amide metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0043604 name: amide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0043605 name: cellular amide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0043606 name: formamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/] synonym: "formamide metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0043607 name: formamide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/] is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0043606 ! formamide metabolic process [Term] id: GO:0043608 name: formamide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/] is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0043606 ! formamide metabolic process [Term] id: GO:0043609 name: regulation of carbon utilization namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of carbon utilization." [GOC:jl] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0015976 ! carbon utilization [Term] id: GO:0043610 name: regulation of carbohydrate utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of carbohydrate utilization." [GOC:jl] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0009758 ! carbohydrate utilization [Term] id: GO:0043611 name: isoprene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoprene, C5H8." [GOC:jl] subset: gosubset_prok synonym: "2-methyl-1,3-butadiene metabolic process" EXACT [] synonym: "2-methyl-1,3-butadiene metabolism" EXACT [] synonym: "hemiterpene metabolic process" EXACT [] synonym: "hemiterpene metabolism" EXACT [] synonym: "isoprene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0043612 name: isoprene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoprene, C5H8." [GOC:jl] synonym: "2-methyl-1,3-butadiene biosynthesis" EXACT [] synonym: "2-methyl-1,3-butadiene biosynthetic process" EXACT [] synonym: "hemiterpene biosynthesis" EXACT [] synonym: "hemiterpene biosynthetic process" EXACT [] is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0043611 ! isoprene metabolic process [Term] id: GO:0043613 name: isoprene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8." [GOC:jl] synonym: "2-methyl-1,3-butadiene catabolic process" EXACT [] synonym: "2-methyl-1,3-butadiene catabolism" EXACT [] synonym: "hemiterpene catabolic process" EXACT [] synonym: "hemiterpene catabolism" EXACT [] is_a: GO:0043611 ! isoprene metabolic process is_a: GO:0046247 ! terpene catabolic process [Term] id: GO:0043614 name: multi-eIF complex namespace: cellular_component def: "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [GOC:krc] synonym: "multifactor translation initiation factor (eIF) complex" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0043615 name: astrocyte cell migration namespace: biological_process def: "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators] synonym: "astrocyte migration" EXACT [] synonym: "astrocytic glial cell migration" EXACT [] is_a: GO:0008347 ! glial cell migration [Term] id: GO:0043616 name: keratinocyte proliferation namespace: biological_process def: "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000311] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0043617 name: cellular response to sucrose starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0043618 name: regulation of transcription from RNA polymerase II promoter in response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0043620 ! regulation of DNA-dependent transcription in response to stress [Term] id: GO:0043619 name: regulation of transcription from RNA polymerase II promoter in response to oxidative stress namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] is_a: GO:0034599 ! cellular response to oxidative stress is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress [Term] id: GO:0043620 name: regulation of DNA-dependent transcription in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl, GOC:txnOH] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0043621 name: protein self-association namespace: molecular_function def: "Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl] synonym: "intramolecular protein binding" EXACT [] synonym: "protein self association" EXACT [] synonym: "protein self binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0043622 name: cortical microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] synonym: "cortical microtubule cytoskeleton organization" EXACT [] synonym: "cortical microtubule organisation" EXACT [GOC:curators] synonym: "cortical microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030865 ! cortical cytoskeleton organization is_a: GO:0031122 ! cytoplasmic microtubule organization [Term] id: GO:0043623 name: cellular protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell." [GOC:jl] subset: gosubset_prok is_a: GO:0006461 ! protein complex assembly is_a: GO:0034622 ! cellular macromolecular complex assembly [Term] id: GO:0043624 name: cellular protein complex disassembly namespace: biological_process def: "The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl] subset: gosubset_prok is_a: GO:0034623 ! cellular macromolecular complex disassembly is_a: GO:0043241 ! protein complex disassembly [Term] id: GO:0043625 name: delta DNA polymerase complex namespace: cellular_component alt_id: GO:0005659 def: "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614] synonym: "delta-DNA polymerase complex" EXACT [] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0043626 name: PCNA complex namespace: cellular_component def: "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735] subset: gosubset_prok synonym: "PCNA homotrimer" EXACT [] synonym: "proliferating cell nuclear antigen complex" EXACT [] synonym: "sliding clamp" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0043627 name: response to estrogen stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response to oestrogen stimulus" EXACT [] is_a: GO:0048545 ! response to steroid hormone stimulus [Term] id: GO:0043628 name: ncRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a non-coding RNA molecule." [GOC:jl] synonym: "ncRNA 3' end processing" EXACT [] is_a: GO:0031123 ! RNA 3'-end processing is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0043629 name: ncRNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation." [GOC:dgf, GOC:krc, GOC:rn, PMID:15828860, PMID:15935758, PMID:16374505, PMID:16431988, PMID:18951092] synonym: "non-coding RNA polyadenylation" EXACT [] is_a: GO:0043628 ! ncRNA 3'-end processing is_a: GO:0043631 ! RNA polyadenylation [Term] id: GO:0043630 name: ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process namespace: biological_process def: "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism." [GOC:dph, GOC:jl, GOC:tb] synonym: "ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process" RELATED [GOC:dph, GOC:tb] is_a: GO:0043629 ! ncRNA polyadenylation relationship: part_of GO:0043634 ! polyadenylation-dependent ncRNA catabolic process [Term] id: GO:0043631 name: RNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl] subset: gosubset_prok is_a: GO:0031123 ! RNA 3'-end processing [Term] id: GO:0043632 name: modification-dependent macromolecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] subset: gosubset_prok is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0043633 name: polyadenylation-dependent RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA." [GOC:dgf, GOC:jl, GOC:krc] is_a: GO:0006401 ! RNA catabolic process is_a: GO:0043632 ! modification-dependent macromolecule catabolic process [Term] id: GO:0043634 name: polyadenylation-dependent ncRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc] is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process [Term] id: GO:0043635 name: methylnaphthalene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar." [GOC:jl, PMID:16535687] synonym: "1-methylnaphthalene catabolic process" NARROW [] synonym: "1-methylnaphthalene catabolism" NARROW [] synonym: "1-MN catabolic process" RELATED [] synonym: "1-MN catabolism" RELATED [] synonym: "2-methylnaphthalene catabolic process" NARROW [] synonym: "2-methylnaphthalene catabolism" NARROW [] synonym: "2-MN catabolic process" RELATED [] synonym: "2-MN catabolism" RELATED [] is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0043636 name: bisphenol A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins." [CHEBI:33216, GOC:jl, Wikipedia:Bisphenol_A] synonym: "bisphenol-A catabolic process" EXACT [] synonym: "bisphenol-A catabolism" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0043637 name: puromycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [CHEBI:17939, GOC:jl, PMID:8226694, Wikipedia:Puromycin] subset: gosubset_prok synonym: "puromycin metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0043638 name: puromycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [CHEBI:17939, GOC:jl, Wikipedia:Puromycin] subset: gosubset_prok is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0043637 ! puromycin metabolic process [Term] id: GO:0043639 name: benzoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl] subset: gosubset_prok synonym: "benzoate breakdown" EXACT [] synonym: "benzoate catabolism" EXACT [] synonym: "benzoate degradation" EXACT [] is_a: GO:0018874 ! benzoate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0043640 name: benzoate catabolic process via hydroxylation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GOC:jl, MetaCyc:PWY-2503] synonym: "benzoate breakdown via hydroxylation" EXACT [] synonym: "benzoate degradation via hydroxylation" EXACT [] xref: MetaCyc:PWY-2503 is_a: GO:0043639 ! benzoate catabolic process [Term] id: GO:0043641 name: novobiocin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [CHEBI:28368, GOC:jl] subset: gosubset_prok synonym: "novobiocin metabolism" EXACT [] xref: Wikipedia:Novobiocin is_a: GO:0009804 ! coumarin metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0043642 name: novobiocin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [CHEBI:28368, GOC:jl] subset: gosubset_prok xref: Wikipedia:Novobiocin is_a: GO:0009805 ! coumarin biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0043641 ! novobiocin metabolic process [Term] id: GO:0043643 name: tetracycline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:jl, Wikipedia:Tetracycline] subset: gosubset_prok synonym: "tetracyclin metabolic process" EXACT [] synonym: "tetracyclin metabolism" EXACT [] synonym: "tetracycline metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process [Term] id: GO:0043644 name: tetracycline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:jl, Wikipedia:Tetracycline] subset: gosubset_prok synonym: "tetracyclin biosynthesis" EXACT [] synonym: "tetracyclin biosynthetic process" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0043643 ! tetracycline metabolic process [Term] id: GO:0043645 name: cephalosporin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [CHEBI:23066, GOC:jl, Wikipedia:Cephalosporin] subset: gosubset_prok synonym: "cephalosporin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process [Term] id: GO:0043646 name: cephalosporin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [CHEBI:23066, GOC:jl, Wikipedia:Cephalosporin] subset: gosubset_prok is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process is_a: GO:0043645 ! cephalosporin metabolic process [Term] id: GO:0043647 name: inositol phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, GOC:jl] synonym: "inositol phosphate metabolism" EXACT [] synonym: "myo-inositol phosphate metabolic process" NARROW [] synonym: "myo-inositol phosphate metabolism" NARROW [] is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0043648 name: dicarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dicarboxylate metabolic process" EXACT [] synonym: "dicarboxylate metabolism" EXACT [] synonym: "dicarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0043649 name: dicarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dicarboxylate catabolic process" EXACT [] synonym: "dicarboxylate catabolism" EXACT [] synonym: "dicarboxylic acid breakdown" EXACT [] synonym: "dicarboxylic acid catabolism" EXACT [] synonym: "dicarboxylic acid degradation" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0043650 name: dicarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dicarboxylate biosynthesis" EXACT [] synonym: "dicarboxylate biosynthetic process" EXACT [] synonym: "dicarboxylic acid anabolism" EXACT [] synonym: "dicarboxylic acid biosynthesis" EXACT [] synonym: "dicarboxylic acid formation" EXACT [] synonym: "dicarboxylic acid synthesis" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0043651 name: linoleic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [Wikipedia:Linoleic_Acid] synonym: "linoleic acid metabolism" EXACT [] xref: Wikipedia:Linoleic_acid is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0043652 name: engulfment of apoptotic cell namespace: biological_process def: "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015] synonym: "engulfment of apoptotic cell corpse" EXACT [] synonym: "engulfment of cell corpse" EXACT [] is_a: GO:0006911 ! phagocytosis, engulfment relationship: part_of GO:0043277 ! apoptotic cell clearance [Term] id: GO:0043653 name: mitochondrial fragmentation involved in apoptosis namespace: biological_process def: "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:rk, PMID:12867994] synonym: "mitochondrial fission during apoptosis" RELATED [GOC:dph, GOC:tb] is_a: GO:0000266 ! mitochondrial fission is_a: GO:0008637 ! apoptotic mitochondrial changes [Term] id: GO:0043654 name: recognition of apoptotic cell namespace: biological_process def: "The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis." [GOC:rk, PMID:15536015] synonym: "detection of apoptotic cell" EXACT [] synonym: "detection of apoptotic cell corpse" EXACT [] synonym: "detection of cell corpse" EXACT [] synonym: "recognition of apoptotic cell corpse" EXACT [] synonym: "recognition of cell corpse" EXACT [] is_a: GO:0006910 ! phagocytosis, recognition relationship: part_of GO:0043277 ! apoptotic cell clearance [Term] id: GO:0043655 name: extracellular space of host namespace: cellular_component def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc] subset: gosubset_prok synonym: "host extracellular space" EXACT [] is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0018995 ! host [Term] id: GO:0043656 name: intracellular region of host namespace: cellular_component def: "That space within the plasma membrane of a host cell." [GOC:cc] subset: gosubset_prok synonym: "host intracellular" EXACT [] is_a: GO:0033643 ! host cell part [Term] id: GO:0043657 name: host cell namespace: cellular_component def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl] subset: gosubset_prok is_a: GO:0044216 ! other organism cell relationship: part_of GO:0018995 ! host [Term] id: GO:0043658 name: host symbiosome namespace: cellular_component def: "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [GOC:cc] subset: gosubset_prok is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0043659 name: symbiosome namespace: cellular_component def: "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [GOC:cc] subset: gosubset_prok is_a: GO:0030139 ! endocytic vesicle [Term] id: GO:0043660 name: bacteroid-containing symbiosome namespace: cellular_component def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [GOC:cc] subset: gosubset_prok is_a: GO:0043659 ! symbiosome [Term] id: GO:0043661 name: peribacteroid membrane namespace: cellular_component def: "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] subset: gosubset_prok is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0043660 ! bacteroid-containing symbiosome [Term] id: GO:0043662 name: peribacteroid fluid namespace: cellular_component def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [GOC:cc] subset: gosubset_prok is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0043660 ! bacteroid-containing symbiosome [Term] id: GO:0043663 name: host bacteroid-containing symbiosome namespace: cellular_component def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [GOC:cc] subset: gosubset_prok is_a: GO:0043658 ! host symbiosome [Term] id: GO:0043664 name: host peribacteroid membrane namespace: cellular_component def: "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] subset: gosubset_prok is_a: GO:0033643 ! host cell part relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome [Term] id: GO:0043665 name: host peribacteroid fluid namespace: cellular_component def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [GOC:cc] subset: gosubset_prok is_a: GO:0033643 ! host cell part relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome [Term] id: GO:0043666 name: regulation of phosphoprotein phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821] is_a: GO:0010921 ! regulation of phosphatase activity [Term] id: GO:0043667 name: pollen wall namespace: cellular_component def: "The complex wall surrounding a pollen grain." [GOC:fz] comment: Note that this term is a child of 'extracellular matrix part ; GO:0044420' rather than the more specific middle lamella-containing extracellular matrix ; GO:0048196', because unlike the usual plant cell wall, the pollen wall does not contain a middle lamella, as specified in the definition of 'middle lamella-containing extracellular matrix ; GO:0048196'. synonym: "microspore wall" EXACT [] is_a: GO:0044420 ! extracellular matrix part [Term] id: GO:0043668 name: exine namespace: cellular_component def: "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that the exine is highly resistant to strong acids and bases. is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043667 ! pollen wall [Term] id: GO:0043669 name: ectexine namespace: cellular_component def: "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'. is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043668 ! exine [Term] id: GO:0043670 name: foot layer namespace: cellular_component def: "The inner layer of the ectexine." [http://www.mobot.org/MOBOT/research/APweb/] synonym: "nexine 1" EXACT [] is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043669 ! ectexine [Term] id: GO:0043671 name: endexine namespace: cellular_component def: "The inner part of the exine, which stains." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'. is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043668 ! exine [Term] id: GO:0043672 name: nexine namespace: cellular_component def: "The inner, non-sculptured part of the exine which lies below the sexine." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'. is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043668 ! exine [Term] id: GO:0043673 name: sexine namespace: cellular_component def: "The outer, sculptured layer of the exine, which lies above the nexine." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'. is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043668 ! exine [Term] id: GO:0043674 name: columella namespace: cellular_component def: "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [http://www.mobot.org/MOBOT/research/APweb/] synonym: "sexine 1" EXACT [] is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043673 ! sexine [Term] id: GO:0043675 name: sculpture element namespace: cellular_component def: "The third layer of the sexine." [http://www.mobot.org/MOBOT/research/APweb/] is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043673 ! sexine [Term] id: GO:0043676 name: tectum namespace: cellular_component def: "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [http://www.mobot.org/MOBOT/research/APweb/] synonym: "sexine 2" EXACT [] is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043673 ! sexine [Term] id: GO:0043677 name: germination pore namespace: cellular_component def: "A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [Wikipedia:Germ_pore] synonym: "germ pore" EXACT [] xref: Wikipedia:Germ_pore is_a: GO:0044420 ! extracellular matrix part [Term] id: GO:0043678 name: intine namespace: cellular_component def: "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material. is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0043667 ! pollen wall [Term] id: GO:0043679 name: axon terminus namespace: cellular_component def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl] synonym: "axon terminal" EXACT [] synonym: "axon terminal specialization" RELATED [] synonym: "nerve ending" EXACT [] is_a: GO:0033267 ! axon part is_a: GO:0044306 ! neuron projection terminus [Term] id: GO:0043680 name: filiform apparatus namespace: cellular_component def: "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208] is_a: GO:0044426 ! cell wall part [Term] id: GO:0043682 name: copper-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane." [GOC:jl] subset: gosubset_prok xref: Reactome:262542 "copper-transporting ATPase activity" is_a: GO:0005375 ! copper ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0043683 name: type IV pilus biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a type IV pilus. A type IV pilus is composed of a pilus fiber and approximately ten proteins at its base; type IV pili play a role in cell motility, adherence to substrates, and aggregation." [GOC:jl, GOC:ml] synonym: "TFP biogenesis" EXACT [] synonym: "type 4 pilus biogenesis" EXACT [] synonym: "type IV fimbria assembly" EXACT [] synonym: "type IV fimbria biogenesis" EXACT [] synonym: "type IV fimbriae assembly" EXACT [] synonym: "type IV fimbriae biogenesis" EXACT [] synonym: "type IV fimbrial assembly" EXACT [] synonym: "type IV fimbrial biogenesis" EXACT [] synonym: "type IV fimbrium assembly" EXACT [] synonym: "type IV fimbrium biogenesis" EXACT [] synonym: "type IV pilus biosynthesis" EXACT [] is_a: GO:0009297 ! pilus assembly is_a: GO:0071843 ! cellular component biogenesis at cellular level [Term] id: GO:0043684 name: type IV secretion system complex namespace: cellular_component def: "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s)." [GOC:ml] subset: gosubset_prok synonym: "T4SS complex" EXACT [] synonym: "type IV protein secretion system complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0043685 name: conversion of glutamyl-tRNA to glutaminyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA." [GOC:jsg, PMID:3340166, PMID:9342308] comment: Note that this process has been observed in some archaeal and bacterial species. subset: gosubset_prok is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0043686 name: co-translational protein modification namespace: biological_process def: "The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome." [GOC:jsg] comment: This term should only be used to annotate a protein modification process that occurs after the start of translation but while the protein is still on the ribosome. synonym: "co-translational amino acid modification" EXACT [] synonym: "co-translational modification" EXACT [] synonym: "cotranslational amino acid modification" EXACT [] synonym: "cotranslational modification" EXACT [] synonym: "cotranslational protein modification" EXACT [] is_a: GO:0006464 ! protein modification process [Term] id: GO:0043687 name: post-translational protein modification namespace: biological_process def: "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] comment: This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term. subset: gosubset_prok synonym: "post-translational amino acid modification" EXACT [] synonym: "post-translational modification" EXACT [] synonym: "posttranslational amino acid modification" EXACT [] synonym: "posttranslational modification" EXACT [] synonym: "posttranslational protein modification" EXACT [] synonym: "PTM" EXACT [] xref: Reactome:1253303 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1253304 "Post-translational protein modification" xref: Reactome:1280243 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1280244 "Post-translational protein modification" xref: Reactome:1299103 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1299104 "Post-translational protein modification" xref: Reactome:1326819 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1326820 "Post-translational protein modification" xref: Reactome:1352920 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1352921 "Post-translational protein modification" xref: Reactome:1373126 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1373127 "Post-translational protein modification" xref: Reactome:1393142 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1393143 "Post-translational protein modification" xref: Reactome:1417625 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1417626 "Post-translational protein modification" xref: Reactome:1450725 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1450726 "Post-translational protein modification" xref: Reactome:1471181 "Post-translational protein modification" xref: Reactome:1471338 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1483173 "Post-translational protein modification" xref: Reactome:1496876 "Post-translational protein modification" xref: Reactome:1496988 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1514269 "Post-translational protein modification" xref: Reactome:1514375 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1521120 "Post-translational protein modification" xref: Reactome:1521250 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1526886 "Post-translational protein modification" xref: Reactome:1526966 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1532615 "Post-translational protein modification" xref: Reactome:1532702 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:1536063 "Post-translational protein modification" xref: Reactome:1536108 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:163841 "Post-translational modification: gamma carboxylation and hypusine formation" xref: Reactome:597592 "Post-translational protein modification" xref: Wikipedia:Posttranslational_modification is_a: GO:0006464 ! protein modification process [Term] id: GO:0043688 name: conversion of aspartyl-tRNA to asparaginyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA." [GOC:jsg, PMID:9789001] comment: Note that this process has been observed in some archeal and bacterial species. subset: gosubset_prok is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0043689 name: cell-cell adhesion involved in flocculation namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules, occurring as a part of the non-sexual aggregation of single-celled organisms." [GOC:jl] subset: gosubset_prok is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0000128 ! flocculation [Term] id: GO:0043690 name: cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "The attachment of one cell to another cell via protein-carbohydrate (flocculin-mannan) interaction, occurring as a part of the mannose-sensitive, nonsexual aggregation of cells." [GOC:jl] subset: gosubset_prok is_a: GO:0007157 ! heterophilic cell-cell adhesion is_a: GO:0016339 ! calcium-dependent cell-cell adhesion is_a: GO:0043689 ! cell-cell adhesion involved in flocculation relationship: part_of GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction [Term] id: GO:0043691 name: reverse cholesterol transport namespace: biological_process def: "The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism." [GOC:ecd, PMID:7751809] is_a: GO:0030301 ! cholesterol transport [Term] id: GO:0043692 name: monoterpene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure." [CHEBI:35187] subset: gosubset_prok synonym: "monoterpene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0043693 name: monoterpene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure." [CHEBI:35187] subset: gosubset_prok synonym: "monoterpene biosynthesis" EXACT [] is_a: GO:0043692 ! monoterpene metabolic process is_a: GO:0046246 ! terpene biosynthetic process [Term] id: GO:0043694 name: monoterpene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure." [CHEBI:35187] subset: gosubset_prok synonym: "monoterpene catabolism" EXACT [] is_a: GO:0043692 ! monoterpene metabolic process is_a: GO:0046247 ! terpene catabolic process [Term] id: GO:0043695 name: detection of pheromone namespace: biological_process def: "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal." [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0019236 ! response to pheromone [Term] id: GO:0043696 name: dedifferentiation namespace: biological_process def: "The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors." [GOC:dph, GOC:pg] xref: Wikipedia:Cellular_differentiation#Dedifferentiation is_a: GO:0032502 ! developmental process [Term] id: GO:0043697 name: cell dedifferentiation namespace: biological_process def: "The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg] comment: Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer. is_a: GO:0043696 ! dedifferentiation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0043698 name: iridosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance." [GOC:mh] synonym: "reflecting platelet" EXACT [] is_a: GO:0048770 ! pigment granule [Term] id: GO:0043699 name: leucosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast." [GOC:mh] synonym: "refractosome" EXACT [] is_a: GO:0048770 ! pigment granule [Term] id: GO:0043700 name: pterinosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] is_a: GO:0048770 ! pigment granule [Term] id: GO:0043701 name: cyanosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance." [GOC:mh] is_a: GO:0048770 ! pigment granule [Term] id: GO:0043702 name: carotenoid vesicle namespace: cellular_component def: "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vescicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0043703 name: photoreceptor cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu] is_a: GO:0048664 ! neuron fate determination relationship: part_of GO:0046552 ! photoreceptor cell fate commitment [Term] id: GO:0043704 name: photoreceptor cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu] is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0046552 ! photoreceptor cell fate commitment [Term] id: GO:0043705 name: cyanophycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups." [GOC:jl] synonym: "cyanophycin metabolism" EXACT [] synonym: "multi-L-arginyl-poly(L-aspartic acid) metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0043706 name: heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein namespace: biological_process def: "The attachment of a parasite adhesion molecule to a nonidentical adhesion molecule on the microvasculature of a host cell, thereby adhering the parasite to the host cell." [GOC:jl] is_a: GO:0007157 ! heterophilic cell-cell adhesion relationship: part_of GO:0020035 ! cytoadherence to microvasculature, mediated by symbiont protein [Term] id: GO:0043707 name: cell adhesion involved in single-species biofilm formation in or on host organism namespace: biological_process def: "The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a surface in a host species." [GOC:jl] synonym: "cell adhesion during single-species biofilm formation in or on host organism" RELATED [GOC:dph] is_a: GO:0043709 ! cell adhesion involved in single-species biofilm formation relationship: part_of GO:0044407 ! single-species biofilm formation in or on host organism [Term] id: GO:0043708 name: cell adhesion involved in biofilm formation namespace: biological_process def: "The attachment of a cell to a surface, via cell adhesion molecules, contributing to the formation of a biofilm." [GOC:dph, GOC:jl, GOC:tb] synonym: "cell adhesion during biofilm formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0007155 ! cell adhesion relationship: part_of GO:0042710 ! biofilm formation [Term] id: GO:0043709 name: cell adhesion involved in single-species biofilm formation namespace: biological_process def: "The attachment of a cell to a surface, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species." [GOC:dph, GOC:jl, GOC:tb] synonym: "cell adhesion during single-species biofilm formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043708 ! cell adhesion involved in biofilm formation relationship: part_of GO:0044010 ! single-species biofilm formation [Term] id: GO:0043710 name: cell adhesion involved in multi-species biofilm formation namespace: biological_process def: "The attachment of a cell to a surface, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species." [GOC:dph, GOC:jl, GOC:tb] synonym: "cell adhesion during multi-species biofilm formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043708 ! cell adhesion involved in biofilm formation relationship: part_of GO:0044399 ! multi-species biofilm formation [Term] id: GO:0043711 name: pilus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies." [GOC:jl] subset: gosubset_prok synonym: "pilus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030030 ! cell projection organization [Term] id: GO:0043712 name: 2-hydroxyisocaproate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoisocaproate + CoA = (R)-2-hydroxyisocaproyl-CoA." [PMID:16957230] synonym: "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT [] synonym: "(R)-2-hydroxyisocaproate CoA-transferase activity" EXACT [] is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0043713 name: (R)-2-hydroxyisocaproate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+." [GOC:jl, PMID:16957230] subset: gosubset_prok xref: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0043714 name: (R)-citramalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA." [GOC:jl, PMID:9864346] subset: gosubset_prok synonym: "citramalate synthase" BROAD [] xref: EC:2.3.3.- xref: MetaCyc:RXN-7743 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0043715 name: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P). 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P." [MetaCyc:R82-RXN] comment: This function is part of the process of methionine salvage. subset: gosubset_prok synonym: "DK-MTP-1-P enolase activity" EXACT [] synonym: "E-1" RELATED [] synonym: "MasA" RELATED [] synonym: "mtnW" RELATED [] xref: EC:5.3.2.- xref: MetaCyc:R82-RXN is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0043716 name: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene." [EC:3.1.3.77, IMG:01681, MetaCyc:R83-RXN] subset: gosubset_prok synonym: "2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity" EXACT [MetaCyc:R83-RXN] synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT [] xref: KEGG:R07394 xref: MetaCyc:R83-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043717 name: 2-hydroxyglutaryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA." [MetaCyc:RXN-1083] subset: gosubset_prok synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT [] xref: MetaCyc:RXN-1083 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043718 name: 2-hydroxymethylglutarate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH." [EC:1.1.1.291, RHEA:15508] subset: gosubset_prok synonym: "(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.291] synonym: "HgD" EXACT [] xref: EC:1.1.1.291 xref: KEGG:R07985 xref: MetaCyc:1.1.1.291-RXN xref: RHEA:15508 xref: Wikipedia:2-hydroxymethylglutarate_dehydrogenase is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0043719 name: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O." [GOC:jl, MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN] subset: gosubset_prok xref: EC:1.14.13.- xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0043720 name: 3-keto-5-aminohexanoate cleavage activity namespace: molecular_function def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [PMID:13064] subset: gosubset_prok synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT [] xref: MetaCyc:R125-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043721 name: 4-hydroxybutanoyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O." [EC:4.2.1.120] subset: gosubset_prok synonym: "4-hydroxybutanoyl-CoA hydro-lyase" EXACT [] synonym: "4-hydroxybutyryl-CoA dehydratase activity" EXACT [] synonym: "gamma-hydroxybutanoyl-CoA dehydratase activity" EXACT [] synonym: "gamma-hydroxybutyryl-CoA dehydratase activity" EXACT [] xref: EC:4.2.1.120 xref: KEGG:R05337 xref: MetaCyc:RXN-8890 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043722 name: 4-hydroxyphenylacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H(+) = 4-cresol + CO(2)." [EC:4.1.1.83, RHEA:22735] subset: gosubset_prok synonym: "4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)" EXACT [EC:4.1.1.83] synonym: "4-Hpd activity" EXACT [EC:4.1.1.83] synonym: "4-hydroxyphenylacetate carboxy-lyase activity" EXACT [EC:4.1.1.83] synonym: "p-Hpd activity" EXACT [EC:4.1.1.83] synonym: "p-hydroxyphenylacetate decarboxylase activity" EXACT [EC:4.1.1.83] xref: EC:4.1.1.83 xref: KEGG:R07312 xref: MetaCyc:4.1.1.83-RXN xref: RHEA:22735 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0043723 name: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity namespace: molecular_function alt_id: GO:0017173 def: "Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia." [MetaCyc:RXN-10058, PMID:11889103] subset: gosubset_prok synonym: "2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity" EXACT [MetaCyc:YOL066C-MONOMER] synonym: "DRAP deaminase activity" EXACT [] xref: EC:3.5.4.- xref: MetaCyc:RXN-10058 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0043724 name: 2-keto-3-deoxygalactonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate." [PMID:12824170] subset: gosubset_prok synonym: "KDGal aldolase activity" EXACT [] xref: EC:4.2.1.- is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043725 name: 2-keto-3-deoxygluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate." [PMID:12824170] subset: gosubset_prok synonym: "KDG aldolase activity" EXACT [] xref: EC:4.2.1.- xref: MetaCyc:DHDOGALDOL-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043726 name: 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity namespace: molecular_function alt_id: GO:0019173 def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl, IMG:01282] subset: gosubset_prok synonym: "pyrimidine phosphatase activity" EXACT [GOC:mah] xref: EC:3.1.3.- xref: MetaCyc:RIBOPHOSPHAT-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043727 name: 5-amino-4-imidazole carboxylate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate." [GOC:jl, IMG:01835] subset: gosubset_prok xref: EC:4.1.1.- is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0043728 name: 2-keto-4-methylthiobutyrate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine." [GOC:jl, IMG:01683] subset: gosubset_prok xref: EC:4.1.1.- is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043729 name: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate." [GOC:jl, IMG:01536] subset: gosubset_prok xref: EC:4.-.-.- is_a: GO:0016829 ! lyase activity [Term] id: GO:0043730 name: 5-ureido-4-imidazole carboxylate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2." [GOC:jl, IMG:02121] subset: gosubset_prok xref: EC:3.5.3.- is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0043731 name: 6-hydroxynicotinate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591] subset: gosubset_prok xref: EC:1.14.13.- is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0043732 name: 6-hydroxynicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxynicotinate + H(2)O + O(2) = 2,6-dihydroxynicotinate + H(2)O(2)." [EC:1.17.3.3, RHEA:22811] subset: gosubset_prok synonym: "6-hydroxynicotinate hydroxylase activity" EXACT [EC:1.17.3.3] synonym: "6-hydroxynicotinate:O2 oxidoreductase activity" EXACT [EC:1.17.3.3] synonym: "6-hydroxynicotinic acid dehydrogenase activity" EXACT [EC:1.17.3.3] synonym: "6-hydroxynicotinic acid hydroxylase activity" EXACT [EC:1.17.3.3] xref: EC:1.17.3.3 xref: KEGG:R07221 xref: MetaCyc:RXN-7585 xref: RHEA:22811 is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: GO:0043733 name: DNA-3-methyladenine glycosylase III activity namespace: molecular_function def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated 3-methylpurines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site." [IMG:00576, PMID:10777493, PMID:14517230] subset: gosubset_prok synonym: "Mag III" NARROW [] synonym: "MagIII" NARROW [] xref: EC:3.2.2.- xref: IMG:00576 is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity [Term] id: GO:0043734 name: DNA-N1-methyladenine dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methylgroup on N1-methyladenine and N3-methylcytosine as formaldehyde." [IMG:00579, PMID:19786499] subset: gosubset_prok synonym: "AlkB" NARROW [] synonym: "alkB" NARROW [] synonym: "alpha-ketoglutarate-dependent dioxygenase" NARROW [] xref: EC:1.14.11.- is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0043736 name: DNA-3-methyladenine glycosylase IV activity namespace: molecular_function def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [IMG:00578, PMID:10375529] subset: gosubset_prok synonym: "Mpg II" NARROW [] synonym: "MpgII" NARROW [] xref: EC:3.2.2.- xref: IMG:00578 is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity [Term] id: GO:0043737 name: deoxyribonuclease V activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate." [EC:3.1.21.7] synonym: "DNase V activity" EXACT [EC:3.1.21.7] synonym: "endodeoxyribonuclease V" EXACT [] synonym: "endonuclease V activity" BROAD [EC:3.1.21.7] synonym: "Escherichia coli endodeoxyribonuclease V activity" NARROW [EC:3.1.21.7] xref: EC:3.1.21.7 xref: MetaCyc:3.1.21.7-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0043738 name: F420H2 dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: methanophenazine + reduced cofactor F420 = dihydromethanophenazine + cofactor F420." [MetaCyc:CPLX-7105] subset: gosubset_prok xref: EC:1.-.-.- xref: MetaCyc:CPLX-7105 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043739 name: G/U mismatch-specific uracil-DNA glycosylase activity namespace: molecular_function def: "Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site." [IMG:00570, SP:O59825] subset: gosubset_prok synonym: "GU mismatch-specific uracil-DNA glycosylase activity" EXACT [] synonym: "MUG" EXACT [] synonym: "uracil mismatch repair protein" BROAD [] is_a: GO:0004844 ! uracil DNA N-glycosylase activity is_a: GO:0008263 ! pyrimidine-specific mismatch base pair DNA N-glycosylase activity [Term] id: GO:0043740 name: GTP cyclohydrolase IIa activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H(+) + 2 phosphate." [EC:3.5.4.29, RHEA:22471] subset: gosubset_prok synonym: "GTP 8,9-dihydrolase (phosphate-forming)" EXACT [EC:3.5.4.29] synonym: "GTP 8,9-hydrolase (phosphate-forming)" EXACT [] synonym: "GTP cyclohydrolase III activity" NARROW [EC:3.5.4.29] xref: EC:3.5.4.29 xref: KEGG:R07306 xref: MetaCyc:RXN-10055 xref: RHEA:22471 is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0043741 name: L-2-aminoadipate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate + acetyl-CoA = N2-acetyl-L-aminoadipate + CoA." [IMG:01447] subset: gosubset_prok xref: EC:2.3.1.- xref: MetaCyc:RXN-5181 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0043743 name: LPPG:FO 2-phospho-L-lactate transferase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [IMG:01551] subset: gosubset_prok xref: EC:2.7.1.- is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043744 name: N2-acetyl-L-aminoadipate kinase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate + ATP = N2-acetyl-L-aminoadipyl-delta-phosphate + ADP." [IMG:01448] subset: gosubset_prok xref: EC:2.7.2.- xref: MetaCyc:RXN-5182 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0043745 name: N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate." [IMG:01449] subset: gosubset_prok xref: EC:1.2.1.- is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043746 name: N2-acetyl-L-lysine aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine." [IMG:01450] subset: gosubset_prok synonym: "N-acetyl-lysine aminotransferase activity" EXACT [] xref: EC:2.6.1.- is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043747 name: N2-acetyl-L-lysine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine." [IMG:01451] subset: gosubset_prok synonym: "N-acetyl-lysine deacetylase activity" EXACT [] xref: EC:3.5.1.- xref: MetaCyc:RXN-5185 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043748 name: O-succinylbenzoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate." [IMG:01733] subset: gosubset_prok xref: EC:3.5.1.- is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043749 name: phenol, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate." [PMID:15547277] subset: gosubset_prok synonym: "ATP:phenol:water phosphotransferase activity" EXACT [] synonym: "phenol:water dikinase activity" EXACT [] synonym: "phenylphosphate synthase activity" EXACT [] xref: EC:2.7.9.- is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0043750 name: phosphatidylinositol alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol." [EC:2.4.1.57] subset: gosubset_prok synonym: "GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57] synonym: "phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57] xref: EC:2.4.1.57 xref: MetaCyc:2.4.1.57-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0043751 name: polyphosphate:AMP phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP." [PMID:11237733] subset: gosubset_prok synonym: "PAP" EXACT [] synonym: "PPT" BROAD [] xref: EC:2.7.4.- is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0043752 name: adenosylcobinamide kinase activity namespace: molecular_function def: "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)." [EC:2.7.1.156] subset: gosubset_prok synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] synonym: "CobU" RELATED [] synonym: "RTP:adenosylcobinamide phosphotransferase activity" EXACT [] xref: EC:2.7.1.156 xref: MetaCyc:2.7.1.156-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043754 name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168] subset: gosubset_prok synonym: "2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168] synonym: "2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168] synonym: "dihydrolipoyl transacylase activity" EXACT [EC:2.3.1.168] synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT [] xref: EC:2.3.1.168 xref: MetaCyc:2.3.1.168-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043755 name: alpha-ribazole phosphatase activity namespace: molecular_function alt_id: GO:0019175 def: "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate." [EC:3.1.3.73, RHEA:24459] subset: gosubset_prok synonym: "alpha-ribazole-5'-P phosphatase activity" EXACT [] synonym: "alpha-ribazole-5'-phosphate phosphohydrolase activity" EXACT [] synonym: "CobC" RELATED [] xref: EC:3.1.3.73 xref: KEGG:R04594 xref: MetaCyc:RIBAZOLEPHOSPHAT-RXN xref: RHEA:24459 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043756 name: adenosylcobinamide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide + H(2)O = (R)-1-aminopropan-2-ol + adenosylcobyrate." [EC:3.5.1.90, RHEA:23507] subset: gosubset_prok synonym: "adenosylcobinamide amidohydrolase activity" EXACT [EC:3.5.1.90] synonym: "AdoCbi amidohydrolase activity" EXACT [EC:3.5.1.90] synonym: "AdoCbi hydrolase activity" EXACT [EC:3.5.1.90] synonym: "CbiZ" RELATED [] xref: EC:3.5.1.90 xref: KEGG:R05226 xref: MetaCyc:R346-RXN xref: RHEA:23507 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043757 name: adenosylcobinamide-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide." [EC:6.3.1.10] subset: gosubset_prok synonym: "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)" EXACT [] synonym: "AdoCbi-P synthase activity" EXACT [EC:6.3.1.10] synonym: "CbiB" RELATED [] xref: EC:6.3.1.10 xref: MetaCyc:RXN-6261 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0043758 name: acetate-CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA." [EC:6.2.1.13] subset: gosubset_prok synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.13] synonym: "acetate--CoA ligase (ADP-forming) activity" EXACT [] synonym: "acetate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.13] synonym: "acetyl coenzyme A synthetase (adenosine diphosphate-forming)" EXACT [] synonym: "acetyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.13] xref: EC:6.2.1.13 xref: MetaCyc:ACETATE--COA-LIGASE-ADP-FORMING-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0043759 name: branched-chain acyl-CoA synthetase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = ADP + orthophosphate + 2-methylbutanoyl-CoA." [IMG:01425] subset: gosubset_prok synonym: "branched chain acyl CoA synthetase (ADP-forming) activity" EXACT [] synonym: "branched chain acyl-CoA synthetase (ADP-forming) activity" EXACT [] synonym: "branched-chain acyl CoA synthetase (ADP-forming) activity" EXACT [] xref: EC:6.2.1.- is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0043760 name: acetyldiaminopimelate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate." [IMG:00444, PMID:1906065] subset: gosubset_prok synonym: "N-acetyl-diaminopimelate aminotransferase activity" EXACT [] synonym: "N-acetyl-L,L-diaminopimelate aminotransferase activity" EXACT [] xref: EC:2.6.1.- is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043761 name: archaetidylserine synthase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP." [IMG:01567, PMID:12562787] subset: gosubset_prok synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity" EXACT [] synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity" EXACT [] xref: EC:2.7.8.- is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0043762 name: aryl-CoA synthetase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phenylacetate + CoA = ADP + orthophosphate + phenylacetyl-CoA." [IMG:01427] subset: gosubset_prok xref: EC:6.2.1.- is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0043763 name: UTP:glucose-1-phosphate uridylyltransferase regulator activity namespace: molecular_function def: "Modulates the activity of UTP:glucose-1-phosphate uridylyltransferase." [GOC:jl] subset: gosubset_prok synonym: "glucose-1-phosphate uridylyltransferase regulator activity" EXACT [] synonym: "UDP-glucose diphosphorylase regulator activity" EXACT [] synonym: "UDP-glucose pyrophosphorylase regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0043764 name: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier protein]." [IMG:00545, InterPro:IPR007691] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043765 name: T/G mismatch-specific endonuclease activity namespace: molecular_function def: "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine." [IMG:00606, SP:P09184] subset: gosubset_prok synonym: "DNA mismatch endonuclease" BROAD [] synonym: "V.EcoKDcm" RELATED [] synonym: "very short patch repair protein" RELATED [] synonym: "Vsr mismatch endonuclease" RELATED [] xref: EC:3.1.-.- is_a: GO:0004519 ! endonuclease activity [Term] id: GO:0043766 name: Sep-tRNA:Cys-tRNA synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate." [EC:2.5.1.73, IMG:00235, PMID:15790858, PMID:16380427, PMID:17110438] subset: gosubset_prok synonym: "O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity" EXACT [] synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT [] synonym: "SepCysS" RELATED [] xref: EC:2.5.1.73 xref: MetaCyc:RXN-10719 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0043767 name: pyrrolysyl-tRNA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)." [IMG:02553, PMID:15314242, SP:Q8TUB8] subset: gosubset_prok synonym: "PylRS" EXACT [] synonym: "Pyrrolysine-tRNA ligase activity" EXACT [] xref: EC:6.1.1.- xref: MetaCyc:6.1.1.26-RXN is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0043768 name: S-ribosylhomocysteine lyase activity namespace: molecular_function alt_id: GO:0019138 def: "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine." [EC:4.4.1.21, RHEA:17756] subset: gosubset_prok synonym: "3.2.1.148" RELATED [] synonym: "LuxS" RELATED [] synonym: "ribosylhomocysteinase activity" EXACT [] synonym: "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]" RELATED [EC:4.4.1.21] synonym: "S-ribosylhomocysteinase activity" EXACT [] xref: EC:4.4.1.21 xref: KEGG:R01291 xref: MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN xref: RHEA:17756 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0043769 name: Tpg-containing telomere binding complex namespace: cellular_component def: "A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species." [PMID:15353591] subset: gosubset_prok synonym: "telomere complex" BROAD [] is_a: GO:0000782 ! telomere cap complex [Term] id: GO:0043770 name: demethylmenaquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine." [IMG:01848] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043771 name: cytidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cytidine = ADP + CMP." [IMG:01870] subset: gosubset_prok xref: EC:2.7.1.- is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0043772 name: acyl-phosphate glycerol-3-phosphate acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate." [IMG:01872, PMID:17308305] subset: gosubset_prok synonym: "acyl-phosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "acylphosphate glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "acylphosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0043773 name: coenzyme F420-0 gamma-glutamyl ligase activity namespace: molecular_function def: "Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates." [IMG:01552, PMID:17669425] subset: gosubset_prok synonym: "F420-0 gamma-glutamyl ligase activity" EXACT [] xref: EC:6.3.2.- is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0043774 name: coenzyme F420-2 alpha-glutamyl ligase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate." [IMG:01553] subset: gosubset_prok synonym: "F420-2 alpha-glutamyl ligase activity" EXACT [] xref: EC:6.3.2.- is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0043775 name: cobyrinate a,c-diamide synthase activity namespace: molecular_function def: "Catalysis of the reaction: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 orthophosphate." [IMG:01814] subset: gosubset_prok synonym: "cobyrinate a c diamide synthase activity" EXACT [] synonym: "cobyrinate a c-diamide synthase activity" EXACT [] synonym: "cobyrinate a,c diamide synthase activity" EXACT [] xref: EC:6.3.5.- is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0043776 name: cobalt-precorrin-6B C5-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7." [IMG:02115, MetaCyc:RXN-8766] subset: gosubset_prok synonym: "cobalt-precorrin 6B C5-methyltransferase activity" EXACT [] synonym: "precorrin-6 methyltransferase activity" EXACT [] synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] synonym: "precorrin-6Y methylase" BROAD [] xref: EC:2.1.1.- xref: MetaCyc:RXN-8766 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043777 name: cobalt-precorrin-7 C15-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." [IMG:02116, MetaCyc:RXN-8767] subset: gosubset_prok synonym: "cobalt-precorrin 7 C15-methyltransferase activity" EXACT [] synonym: "precorrin-6 methyltransferase" BROAD [] synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] synonym: "precorrin-6Y methylase" BROAD [] xref: EC:2.1.1.- xref: MetaCyc:RXN-8767 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043778 name: cobalt-precorrin-8 methylmutase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate." [IMG:02117, MetaCyc:RXN-8768] subset: gosubset_prok synonym: "cobalt-precorrin 8 methylmutase activity" EXACT [] synonym: "cobalt-precorrin 8X methylmutase activity" EXACT [] synonym: "cobalt-precorrin-8X methylmutase activity" EXACT [] xref: EC:5.4.1.- xref: MetaCyc:RXN-8768 is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0043779 name: cobalt-precorrin-5A acetaldehyde-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde." [IMG:02112, MetaCyc:RXN-8763] subset: gosubset_prok synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT [] xref: MetaCyc:RXN-8763 is_a: GO:0016829 ! lyase activity [Term] id: GO:0043780 name: cobalt-precorrin-5B C1-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [IMG:02112, MetaCyc:RXN-8764] subset: gosubset_prok synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: MetaCyc:RXN-8764 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043781 name: cobalt-factor II C20-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III." [EC:2.1.1.151, IMG:01812] subset: gosubset_prok synonym: "CbiL" NARROW [] synonym: "cobalt-factor II C20 methyltransferase activity" EXACT [] synonym: "cobalt-precorrin-2 C(20)-methyltransferase activity" EXACT [EC:2.1.1.151] synonym: "S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity" EXACT [EC:2.1.1.151] xref: EC:2.1.1.151 xref: MetaCyc:RXN-8760 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043782 name: cobalt-precorrin-3 C17-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine." [IMG:02110, MetaCyc:RXN-8761] subset: gosubset_prok synonym: "cobalt-precorrin 3 C17-methyltransferase activity" EXACT [] synonym: "cobalt-precorrin-3 methylase" BROAD [] synonym: "cobalt-precorrin-3 methyltransferase" BROAD [] synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: MetaCyc:RXN-8761 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043783 name: oxidoreductase activity, oxidizing metal ions with flavin as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor." [EC:1.16.8] subset: gosubset_prok xref: EC:1.16.8 is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions [Term] id: GO:0043784 name: cob(II)yrinic acid a,c-diamide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH(2)." [EC:1.16.8.1, RHEA:24303] subset: gosubset_prok synonym: "cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity" EXACT [] xref: EC:1.16.8.1 xref: KEGG:R05218 xref: MetaCyc:R343-RXN xref: RHEA:24303 is_a: GO:0043783 ! oxidoreductase activity, oxidizing metal ions with flavin as acceptor [Term] id: GO:0043785 name: cinnamoyl-CoA:phenyllactate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate." [EC:2.8.3.17, RHEA:15604] subset: gosubset_prok synonym: "(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity" EXACT [] synonym: "FldA" RELATED [] xref: EC:2.8.3.17 xref: KEGG:R07796 xref: MetaCyc:2.8.3.17-RXN xref: RHEA:15604 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0043786 name: cinnamate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+." [EC:1.3.1.-, IMG:01615, PMID:10849007] subset: gosubset_prok xref: EC:1.3.1.- is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0043788 name: cardiolipin synthetase 2 activity namespace: molecular_function def: "Catalysis of the reaction: 2 1,2-diacyl-sn-glycero-3-[phospho-rac-(1-glycerol)] = cardiolipin + glycerol." [IMG:00156] subset: gosubset_prok synonym: "cardiolipin synthase 2 activity" EXACT [] xref: EC:2.7.8.- is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0043791 name: dimethylamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine." [IMG:01321, MetaCyc:RXN-8100, PMID:9874228] comment: This function is the first step in the pathway of methanogenesis from dimethylamine. subset: gosubset_prok synonym: "dimethylamine:corrinoid methyltransferase activity" EXACT [] synonym: "DMA methyltransferase 1" EXACT [] synonym: "DMAMT 1" EXACT [] synonym: "MT1" BROAD [] synonym: "mtbB1" RELATED [] xref: EC:2.1.1.- xref: MetaCyc:RXN-8100 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043792 name: enamidase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H(2)O = 2-formylglutarate + NH(4)(+)." [EC:3.5.2.18, RHEA:17212] subset: gosubset_prok synonym: "6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity" EXACT [] xref: EC:3.5.2.18 xref: KEGG:R07984 xref: MetaCyc:3.5.2.18-RXN xref: RHEA:17212 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0043793 name: beta-ribofuranosylaminobenzene 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate." [GOC:jl, IMG:01544, PMID:12142414] subset: gosubset_prok synonym: "beta-RFAP synthase activity" EXACT [] xref: MetaCyc:RXN-8124 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0043794 name: formate dehydrogenase (F420) activity namespace: molecular_function def: "Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420." [IMG:01432, PMID:3801411] subset: gosubset_prok xref: EC:1.2.99.- is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0043795 name: glyceraldehyde oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor." [IMG:01506] subset: gosubset_prok xref: EC:1.2.-.-. is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0043796 name: glyceraldehyde dehydrogenase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [IMG:01555] subset: gosubset_prok xref: EC:1.2.1.- is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043797 name: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.6] subset: gosubset_prok synonym: "D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity" EXACT [] synonym: "GAPOR" RELATED [] synonym: "glyceraldehyde-3-phosphate Fd oxidoreductase activity" EXACT [EC:1.2.7.6] synonym: "glyceraldehyde-3-phosphate ferredoxin reductase activity" EXACT [EC:1.2.7.6] xref: EC:1.2.7.6 xref: MetaCyc:1.2.7.6-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043798 name: glycerate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP." [IMG:01510, MetaCyc:GKI-RXN, PMID:14413719] subset: gosubset_prok synonym: "D-glycerate 2-kinase activity" EXACT [] synonym: "glycerate kinase" BROAD [] xref: EC:2.7.1.- xref: MetaCyc:GKI-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: GO:0043799 name: glycine oxidase activity namespace: molecular_function def: "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide." [EC:1.4.3.19] subset: gosubset_prok synonym: "glycine:oxygen oxidoreductase (deaminating)" EXACT [] xref: EC:1.4.3.19 xref: MetaCyc:1.4.3.19-RXN xref: MetaCyc:RXN-8672 xref: MetaCyc:RXN-8673 xref: MetaCyc:RXN-8674 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0043800 name: hexulose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate." [IMG:01502, MetaCyc:R12-RXN, PMID:11839305] subset: gosubset_prok synonym: "HUMPI" EXACT [] xref: EC:5.-.-.- xref: MetaCyc:R12-RXN is_a: GO:0016853 ! isomerase activity [Term] id: GO:0043801 name: hexulose-6-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate." [IMG:01503, PMID:16075199] subset: gosubset_prok xref: EC:4.1.2.- xref: MetaCyc:R10-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0043802 name: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H(2)O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H(+) + hydrogenobyrinate a,c-diamide + 2 phosphate." [EC:6.3.5.9, RHEA:12547] subset: gosubset_prok synonym: "CobB" RELATED [] synonym: "hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity" EXACT [] synonym: "hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)" EXACT [] xref: EC:6.3.5.9 xref: KEGG:R05224 xref: MetaCyc:R341-RXN xref: RHEA:12547 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0043803 name: hydroxyneurosporene-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = spheroidene + S-adenosyl-L-homocysteine." [IMG:01759] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043804 name: imidazolone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-formiminoglycine = imidazolone + H2O." [IMG:02122] subset: gosubset_prok xref: EC:3.5.2.- is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0043805 name: indolepyruvate ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.8] subset: gosubset_prok synonym: "3-(indol-3-yl)pyruvate synthase (ferredoxin) activity" EXACT [EC:1.2.7.8] synonym: "3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)" EXACT [EC:1.2.7.8] synonym: "indolepyruvate oxidoreductase activity" EXACT [EC:1.2.7.8] synonym: "IOR" RELATED [] xref: EC:1.2.7.8 xref: MetaCyc:1.2.7.8-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043806 name: keto acid formate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate." [IMG:00725, MetaCyc:KETOBUTFORMLY-RXN] subset: gosubset_prok synonym: "keto-acid formate acetyltransferase" BROAD [] synonym: "keto-acid formate lyase activity" EXACT [] synonym: "keto-acid formate-lyase activity" EXACT [] xref: EC:2.3.1.- xref: MetaCyc:KETOBUTFORMLY-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043807 name: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.7] subset: gosubset_prok synonym: "2-ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] synonym: "2-oxoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] synonym: "3-methyl-2-oxobutanoate synthase (ferredoxin) activity" EXACT [EC:1.2.7.7] synonym: "3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)" EXACT [] synonym: "branched-chain ketoacid ferredoxin reductase activity" RELATED [EC:1.2.7.7] synonym: "branched-chain oxo acid ferredoxin reductase activity" RELATED [EC:1.2.7.7] synonym: "keto-valine-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.7] synonym: "ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] synonym: "ketoisovalerate oxidoreductase activity" EXACT [EC:1.2.7.7] synonym: "VOR" RELATED [] xref: EC:1.2.7.7 xref: MetaCyc:1.2.7.7-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043808 name: lyso-ornithine lipid acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]." [IMG:02097, PMID:15341653] subset: gosubset_prok is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0043810 name: ornithine-acyl [acyl carrier protein] N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]." [IMG:02096] subset: gosubset_prok synonym: "ornithine-acyl[acyl carrier protein] N-acyltransferase activity" EXACT [] is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0043811 name: phosphate:acyl-[acyl carrier protein] acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]." [IMG:01871] subset: gosubset_prok is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0043812 name: phosphatidylinositol-4-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [IMG:01360] subset: gosubset_prok synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT [] xref: EC:3.1.3.- is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0043813 name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [IMG:01359, PMID:10806194, PMID:16607019] subset: gosubset_prok synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT [] xref: EC:3.1.3.- is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity [Term] id: GO:0043814 name: phospholactate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate." [IMG:01547] subset: gosubset_prok xref: EC:2.7.7.- xref: MetaCyc:RXN-8077 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0043815 name: phosphoribosylglycinamide formyltransferase 2 activity namespace: molecular_function def: "Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate." [IMG:01297, PMID:8117714] subset: gosubset_prok synonym: "5'-phosphoribosylglycinamide transformylase 2" EXACT [] synonym: "formate-dependent GAR transformylase activity" EXACT [] synonym: "GAR transformylase 2" RELATED [] synonym: "GART 2" RELATED [] xref: EC:2.1.2.- is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0043816 name: phosphoserine-tRNA(Cys) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys)." [IMG:00622, PMID:17110438] subset: gosubset_prok synonym: "O-phosphoseryl-tRNA(Cys) synthetase activity" EXACT [] synonym: "phosphoserine--tRNA(Cys) ligase activity" EXACT [] synonym: "phosphoserine-tRNACys ligase activity" EXACT [] synonym: "SepRS" RELATED [] xref: EC:6.1.1.- is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0043817 name: phosphosulfolactate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite." [EC:4.4.1.19, RHEA:22787] subset: gosubset_prok synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.4.1.19] synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase activity" EXACT [] synonym: "(2R)-phospho-3-sulfolactate synthase activity" EXACT [EC:4.4.1.19] synonym: "PSL synthase activity" EXACT [EC:4.4.1.19] xref: EC:4.4.1.19 xref: KEGG:R07476 xref: MetaCyc:4.4.1.19-RXN xref: MetaCyc:R228-RXN xref: RHEA:22787 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0043818 name: precorrin-3B synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B." [EC:1.14.13.83, RHEA:17296] subset: gosubset_prok synonym: "CobG" RELATED [] synonym: "precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)" EXACT [] synonym: "precorrin-3X synthase activity" EXACT [EC:1.14.13.83] xref: EC:1.14.13.83 xref: KEGG:R05217 xref: MetaCyc:R321-RXN xref: RHEA:17296 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0043819 name: precorrin-6A synthase (deacetylating) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H(+) + precorrin-6X." [EC:2.1.1.152, RHEA:18264] subset: gosubset_prok synonym: "CobF" RELATED [] synonym: "precorrin-6X synthase (deacetylating) activity" EXACT [EC:2.1.1.152] synonym: "S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)" EXACT [] xref: EC:2.1.1.152 xref: KEGG:R05219 xref: MetaCyc:R322-RXN xref: RHEA:18264 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043820 name: propionyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA." [PMID:12603323] subset: gosubset_prok xref: EC:1.3.99.- is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0043821 name: propionyl-CoA:succinate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate." [IMG:01589, MetaCyc:RXN0-268] subset: gosubset_prok synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT [] synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT [] xref: EC:2.8.3.- xref: MetaCyc:RXN0-268 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0043822 name: ribonuclease M5 activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor." [EC:3.1.26.8, IMG:02522] subset: gosubset_prok synonym: "5S ribosomal maturation nuclease activity" EXACT [EC:3.1.26.8] synonym: "5S ribosomal RNA maturation endonuclease activity" EXACT [] synonym: "RNase M5 activity" EXACT [EC:3.1.26.8] xref: EC:3.1.26.8 xref: MetaCyc:3.1.26.8-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0043823 name: spheroidene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O." [IMG:01761, MetaCyc:RXN-10670, PMID:16086104, PMID:16158287] subset: gosubset_prok xref: EC:1.14.-.- xref: MetaCyc:RXN-10670 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0043824 name: succinylglutamate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H(2)O + NAD(+) = N-succinyl-L-glutamate + 2 H(+) + NADH." [EC:1.2.1.71, RHEA:10815] subset: gosubset_prok synonym: "AruD" RELATED [] synonym: "AstD" RELATED [] synonym: "N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.71] synonym: "N-succinylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71] synonym: "SGSD" RELATED [] synonym: "succinyl glutamate-semialdehyde dehydrogenase activity" EXACT [] synonym: "succinylglutamic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71] xref: EC:1.2.1.71 xref: KEGG:R05049 xref: MetaCyc:SUCCGLUALDDEHYD-RXN xref: RHEA:10815 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043825 name: succinylornithine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.81, RHEA:16956] subset: gosubset_prok synonym: "2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.81] synonym: "AstC" RELATED [] synonym: "N(2)-succinylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.81] synonym: "N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [] synonym: "N2-succinylornithine 5-aminotransferase activity" EXACT [] synonym: "SOAT" RELATED [] synonym: "succinyl ornithine transaminase activity" EXACT [] synonym: "succinyl-ornithine transaminase activity" EXACT [EC:2.6.1.81] synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.81] xref: EC:2.6.1.81 xref: KEGG:R04217 xref: MetaCyc:SUCCORNTRANSAM-RXN xref: RHEA:16956 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043826 name: sulfur oxygenase reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5 S0 + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide." [IMG:00713, MetaCyc:RXN-8226, PMID:1522063] subset: gosubset_prok synonym: "SOR" RELATED [] synonym: "sulphur oxygenase reductase activity" EXACT [] xref: EC:1.-.-.- xref: MetaCyc:RXN-8226 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043827 name: tRNA (adenine-57, 58-N(1)-) methyltransferase activity namespace: molecular_function def: "Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA." [IMG:00706, PMID:14739239] subset: gosubset_prok synonym: "TrmI" RELATED [] synonym: "tRNA (adenine-57, 58 N1-) methyltransferase activity" EXACT [] synonym: "tRNA (adenine-57, 58-N1-) methyltransferase activity" EXACT [] synonym: "tRNA (m1A) MTase" BROAD [] xref: EC:2.1.1.- is_a: GO:0016429 ! tRNA (adenine-N1-)-methyltransferase activity [Term] id: GO:0043828 name: tRNA 2-selenouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)." [IMG:02609, MetaCyc:RXN0-2281] subset: gosubset_prok synonym: "B0503" RELATED [] synonym: "SelU" RELATED [] synonym: "YbbB" RELATED [] xref: EC:2.9.1.- xref: MetaCyc:RXN0-2281 is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups [Term] id: GO:0043829 name: tRNA-specific adenosine-37 deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [IMG:00703, PMID:8915538, PMID:9707437] subset: gosubset_prok synonym: "TAD1" RELATED [] synonym: "tRNA(Ala)-A37 deaminase activity" EXACT [] synonym: "tRNA-specific adenosine deaminase 1" EXACT [] xref: EC:3.5.4.- is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity [Term] id: GO:0043830 name: thiol-driven fumarate reductase activity namespace: molecular_function def: "Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide." [IMG:01366, PMID:2509466] subset: gosubset_prok xref: EC:1.3.99.- is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0043831 name: thiosulfate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate." [EC:1.8.5.2, RHEA:10939] subset: gosubset_prok synonym: "DoxA" RELATED [] synonym: "DoxD" RELATED [] synonym: "thiosulfate oxidoreductase, tetrathionate-forming activity" EXACT [EC:1.8.5.2] synonym: "thiosulfate:6-decylubiquinone oxidoreductase activity" EXACT [EC:1.8.5.2] synonym: "thiosulfate:quinone oxidoreductase activity" EXACT [EC:1.8.5.2] synonym: "thiosulphate dehydrogenase (quinone) activity" EXACT [] synonym: "thiosulphate:quinone oxidoreductase activity" EXACT [] synonym: "TQO" RELATED [] xref: EC:1.8.5.2 xref: KEGG:R07177 xref: MetaCyc:1.8.5.2-RXN xref: RHEA:10939 is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [Term] id: GO:0043833 name: methylamine-specific methylcobalamin:coenzyme M methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a methylated corrinoid protein + coenzyme M = a corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01318, MetaCyc:RXN-8099] comment: This function is the second step in the pathway of methanogenesis from monomethylamine, dimethylamine and trimethylamine. subset: gosubset_prok synonym: "dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] synonym: "methylamine-specific methylcobalamin:CoM methyltransferase activity" EXACT [] synonym: "methylcobamide:coenzyme M methyltransferase activity" EXACT [] synonym: "methylcobamide:CoM methyltransferase activity" EXACT [] synonym: "methylcobamide:CoM methyltransferase II isozyme A" RELATED [] synonym: "monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] synonym: "MT2" BROAD [] synonym: "MT2-A" RELATED [] synonym: "MtbA" RELATED [] synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] xref: EC:2.1.1.- xref: MetaCyc:RXN-8099 xref: MetaCyc:RXN-8101 xref: MetaCyc:RXN-8103 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043834 name: trimethylamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine." [IMG:01323, MetaCyc:RXN-8102] comment: This function is the first step in the pathway of methanogenesis from trimethylamine. subset: gosubset_prok synonym: "MT1" BROAD [] synonym: "mttB1" RELATED [] synonym: "TMA methyltransferase 1" EXACT [] synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: MetaCyc:RXN-8102 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043835 name: uracil/thymine dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: uracil + H2O + acceptor = barbiturate + reduced acceptor; and thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor." [EC:1.17.99.4, IMG:01821] comment: This term was made obsolete because it represents two separate molecular functions. synonym: "uracil oxidase activity" RELATED [EC:1.17.99.4] synonym: "uracil-thymine oxidase activity" EXACT [EC:1.17.99.4] synonym: "uracil:acceptor oxidoreductase activity" NARROW [] xref: EC:1.17.99.4 is_obsolete: true replaced_by: GO:0050383 replaced_by: GO:0052620 [Term] id: GO:0043836 name: xanthine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate." [IMG:01834, MetaCyc:R127-RXN] subset: gosubset_prok synonym: "xanthinase activity" EXACT [] xref: EC:3.5.2.- xref: MetaCyc:R127-RXN is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0043837 name: valine dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH." [IMG:00766, PMID:10612726, PMID:2803248] subset: gosubset_prok synonym: "ValDH" RELATED [] xref: EC:1.4.1.- is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0043838 name: phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity namespace: molecular_function def: "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol." [IMG:00182, PMID:15795227] comment: Note that Kdo is an abbreviation for 3-deoxy-D-manno-oct-2-ulosonic acid. subset: gosubset_prok synonym: "EptB" RELATED [] synonym: "phosphoethanolamine transferase" BROAD [] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0043839 name: lipid A phosphate methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A." [IMG:02094, PMID:15994324] subset: gosubset_prok synonym: "lipid A 1-phosphomethyltransferase activity" EXACT [] synonym: "lipid A methyltransferase" BROAD [] synonym: "lipid A phosphomethyltransferase activity" EXACT [] synonym: "LmtA" RELATED [] is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0043840 name: branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine." [IMG:01684, PMID:12670965] subset: gosubset_prok synonym: "BCAT" RELATED [] synonym: "branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] synonym: "branched-chain amino acid aminotransferase" BROAD [] synonym: "branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] xref: EC:2.6.1.- xref: MetaCyc:RXN-7708 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043841 name: (S)-lactate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP." [IMG:01546, PMID:11535063] subset: gosubset_prok synonym: "lactate 2-kinase activity" EXACT [] xref: EC:2.7.1.- xref: IMG:01546 xref: MetaCyc:RXN-8076 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043842 name: Kdo transferase activity namespace: molecular_function def: "Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP." [IMG:00549, PMID:1577828, PMID:2033061, PMID:9195966] subset: gosubset_prok synonym: "3-deoxy-D-manno-octulosonic-acid transferase activity" EXACT [] synonym: "kdtA" RELATED [] synonym: "WaaA" RELATED [] xref: EC:2.-.-.- xref: MetaCyc:KDOTRANS-RXN xref: MetaCyc:KDOTRANS2-RXN is_a: GO:0016740 ! transferase activity [Term] id: GO:0043843 name: ADP-specific glucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147, IMG:01468] subset: gosubset_prok synonym: "ADP-dependent glucokinase activity" EXACT [EC:2.7.1.147] synonym: "ADP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.147] xref: EC:2.7.1.147 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043844 name: ADP-specific phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate." [EC:2.7.1.146, IMG:01469] subset: gosubset_prok synonym: "ADP-6-phosphofructokinase activity" EXACT [EC:2.7.1.146] synonym: "ADP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.146] synonym: "ADP-Pfk activity" EXACT [EC:2.7.1.146] synonym: "ADP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.146] xref: EC:2.7.1.146 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043845 name: DNA polymerase III, proofreading complex namespace: cellular_component def: "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity." [IMG:01721, PMID:16973612, Wikipedia:Pol_III] subset: gosubset_prok synonym: "DNA polymerase III, proof-reading complex" EXACT [] synonym: "DNA polymerase III, proof-reading subcomplex" EXACT [] synonym: "DNA polymerase III, proofreading subcomplex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0009360 ! DNA polymerase III complex [Term] id: GO:0043846 name: DNA polymerase III, DnaX complex namespace: cellular_component def: "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:12940977] subset: gosubset_prok synonym: "clamp loader complex" BROAD [] synonym: "DNA polymerase III, clamp loader complex" EXACT [] synonym: "DNA polymerase III, DnaX subcomplex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0009360 ! DNA polymerase III complex [Term] id: GO:0043847 name: DNA polymerase III, DnaX complex, chi/psi subcomplex namespace: cellular_component def: "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III DnaX complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB)." [IMG:01719, PMID:12940977] subset: gosubset_prok synonym: "DNA polymerase III, clamp loader chi/psi subcomplex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0043846 ! DNA polymerase III, DnaX complex [Term] id: GO:0043848 name: excinuclease cho activity namespace: molecular_function def: "Catalysis of the incision of damaged DNA on the 3' side of a lesion, typically at the ninth phosphodiester bond 3' of the damage." [IMG:00499, PMID:11818552] comment: Note that this function occurs as part of nucleotide excision repair (NER). subset: gosubset_prok synonym: "cho" RELATED [] synonym: "endonuclease cho" EXACT [] synonym: "uvrc homolog protein" RELATED [] is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base [Term] id: GO:0043849 name: Ras palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins." [IMG:00473, PMID:16000296] subset: gosubset_prok synonym: "DHHC cysteine-rich domain-containing protein ERF2" RELATED [] synonym: "ERF2" RELATED [] synonym: "palmitoyltransferase ERF2" RELATED [] synonym: "Ras protein acyltransferase activity" EXACT [] xref: EC:2.3.1.- is_a: GO:0016409 ! palmitoyltransferase activity [Term] id: GO:0043850 name: RecFOR complex namespace: cellular_component def: "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair." [IMG:01764, PMID:12769856] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0043851 name: methanol-specific methylcobalamin:coenzyme M methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the methyl group from the methylated corrinoid cofactor of a methanol corrinoid protein to coenzyme M." [IMG:01315, MetaCyc:RXN-8096] comment: This function is the second step in the pathway of methanogenesis from methanol. subset: gosubset_prok synonym: "methanol-specific methylcobalamin: coenzyme M methyltransferase activity" EXACT [] synonym: "methanol-specific methylcobalamin:CoM methyltransferase activity" EXACT [] synonym: "methyltransferase 2" BROAD [] synonym: "MT2" BROAD [] synonym: "MtaA" RELATED [] synonym: "MtaC protein: coenzyme M methyltransferase activity" EXACT [] synonym: "MtaC protein:coenzyme M methyltransferase activity" EXACT [] xref: EC:2.1.1.- xref: MetaCyc:RXN-8096 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043852 name: monomethylamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3." [IMG:01319, MetaCyc:RXN-8098] comment: This function is the first step in the pathway of methanogenesis from monomethylamine. subset: gosubset_prok synonym: "MMAMT" RELATED [] synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT [] synonym: "MtmB" RELATED [] xref: EC:2.1.1.- xref: MetaCyc:RXN-8098 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043853 name: methanol-CoM methyltransferase complex namespace: cellular_component def: "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol." [IMG:01437, MetaCyc:CPLX-421, PMID:9363780] subset: gosubset_prok synonym: "methanol-coenzyme M methyltransferase complex" EXACT [] synonym: "methanol: coenzyme M methyltransferase complex" EXACT [] synonym: "methanol: CoM methyltransferase complex" EXACT [] synonym: "methanol:coenzyme M methyltransferase complex" EXACT [] synonym: "methanol:CoM methyltransferase complex" EXACT [] xref: MetaCyc:CPLX-421 is_a: GO:0034708 ! methyltransferase complex [Term] id: GO:0043854 name: cyclic nucleotide-gated mechanosensitive ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl, IMG:02416] subset: gosubset_prok synonym: "cyclic nucleotide gated mechanosensitive ion channel activity" EXACT [] synonym: "cyclic nucleotide regulated mechanosensitive ion channel" EXACT [] synonym: "cyclic nucleotide-regulated mechanosensitive ion channel" EXACT [] synonym: "cyclic nucleotide-regulated small mechanosensitive ion channel" RELATED [] synonym: "MscS" RELATED [] synonym: "small conductance mechanosensitive ion channel" EXACT [] is_a: GO:0008381 ! mechanically-gated ion channel activity is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity [Term] id: GO:0043855 name: cyclic nucleotide-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl] subset: gosubset_prok synonym: "cyclic nucleotide activated ion channel activity" EXACT [] synonym: "cyclic nucleotide gated ion channel activity" EXACT [] synonym: "cyclic nucleotide-activated ion channel activity" EXACT [] is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0043856 name: anti-sigma factor antagonist activity namespace: molecular_function def: "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity." [GOC:jl, GOC:txnOH, PMID:15576799] subset: gosubset_prok synonym: "anti-anti-sigma factor activity" EXACT [] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0043857 name: N-acetylornithine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H(+) + phosphate." [EC:2.1.3.9, RHEA:18612] subset: gosubset_prok synonym: "acetylornithine transcarbamylase activity" EXACT [] synonym: "AOTC" RELATED [] synonym: "carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9] synonym: "carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9] synonym: "N-acetylornithine transcarbamylase activity" EXACT [] xref: EC:2.1.3.9 xref: KEGG:R07245 xref: MetaCyc:2.1.3.9-RXN xref: RHEA:18612 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0043858 name: arginine:ornithine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)." [GOC:jl, PMID:17110979] subset: gosubset_prok synonym: "ArcD" RELATED [] synonym: "arginine-ornithine antiporter activity" EXACT [] synonym: "arginine/ornithine antiporter activity" EXACT [] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0043859 name: cyanophycinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok xref: EC:3.-.-.- is_obsolete: true replaced_by: GO:0008236 [Term] id: GO:0043860 name: cyanophycin synthetase activity namespace: molecular_function def: "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)." [EC:6.3.2.29, EC:6.3.2.30, GOC:jl] subset: gosubset_prok synonym: "cphA" RELATED [] xref: EC:6.3.1.- is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0043861 name: agmatine:putrescine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)." [GOC:jl, PMID:17028272] subset: gosubset_prok synonym: "agmatine-putrescine antiporter activity" EXACT [] synonym: "agmatine/putrescine antiporter activity" EXACT [] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0043862 name: arginine:agmatine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)." [GOC:jl, PMID:17099215] subset: gosubset_prok synonym: "AdiC" RELATED [] synonym: "arginine-agmatine antiporter activity" EXACT [] synonym: "arginine-agmatine exchange transporter activity" EXACT [] synonym: "arginine/agmatine antiporter activity" EXACT [] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0043863 name: 4-hydroxy-2-ketopimelate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate." [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN] subset: gosubset_prok synonym: "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity" EXACT [] synonym: "HHED aldolase activity" EXACT [] synonym: "HpaI" RELATED [] synonym: "HpcH" RELATED [] xref: EC:4.1.2.- xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0043864 name: indoleacetamide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA." [GOC:jl, MetaCyc:RXNN-404] subset: gosubset_prok synonym: "IaaH" RELATED [] synonym: "IAH" EXACT [] synonym: "indole acetamide hydrolase activity" EXACT [] synonym: "indole-3-acetamide hydrolase activity" EXACT [] synonym: "Tms2" RELATED [] xref: EC:3.5.1.- is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043865 name: methionine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of methionine from one side of a membrane to the other." [GOC:jl] subset: gosubset_prok is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0043866 name: adenylyl-sulfate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin." [EC:1.8.4.10] subset: gosubset_prok synonym: "AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [] synonym: "AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.10] synonym: "thioredoxin-dependent 5'-adenylylsulfate reductase activity" EXACT [] xref: EC:1.8.4.10 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0043867 name: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine." [PMID:16407303, PMID:7748953] subset: gosubset_prok synonym: "archaeal tRNA-guanine transglycosylase activity" EXACT [] synonym: "archaeosine tRNA-ribosyltransferase activity" EXACT [] synonym: "TgtA" RELATED [] xref: EC:2.4.2.- is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0043868 name: N-acetylaminoadipate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate." [PMID:10613839] subset: gosubset_prok synonym: "acetylaminoadipate kinase activity" EXACT [] synonym: "LysZ" RELATED [] synonym: "N-acetyl-L-aminoadipate 5-phosphotransferase activity" EXACT [] xref: EC:2.7.2.- xref: MetaCyc:RXN-5182 is_a: GO:0016301 ! kinase activity [Term] id: GO:0043869 name: alpha-aminoadipate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A." [MetaCyc:RXN-5181, PMID:10613839, PMID:12925802] subset: gosubset_prok synonym: "lysine biosynthesis protein" RELATED [] synonym: "LysX" RELATED [] synonym: "RimK" RELATED [] xref: MetaCyc:RXN-5181 is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0043870 name: N-acetyl-gamma-aminoadipyl-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH." [MetaCyc:RXN-5183] comment: This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway. subset: gosubset_prok synonym: "AGPR" RELATED [] synonym: "ArgC" RELATED [] synonym: "LysY" RELATED [] synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT [] synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT [] synonym: "NAGSA dehydrogenase activity" BROAD [] xref: EC:1.2.1.- xref: MetaCyc:RXN-5183 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043871 name: delta1-piperideine-6-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [MetaCyc:RXN-8162, PMID:16237033] comment: This function is part of the pipecolate pathway of lysine catabolism. subset: gosubset_prok synonym: "AmaB" RELATED [] synonym: "PIPOX" RELATED [] xref: MetaCyc:RXN-8162 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043872 name: lysine:cadaverine antiporter activity namespace: molecular_function alt_id: GO:0015497 def: "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)." [GOC:jl, PMID:10986235, TC:2.A.3.2.2] subset: gosubset_prok synonym: "cadaverine:lysine antiporter activity" EXACT [] synonym: "CadB" RELATED [] synonym: "lysine-cadaverine antiporter activity" EXACT [] synonym: "lysine/cadaverine antiporter activity" EXACT [] is_a: GO:0015189 ! L-lysine transmembrane transporter activity is_a: GO:0015300 ! solute:solute antiporter activity is_a: GO:0015490 ! cadaverine transmembrane transporter activity [Term] id: GO:0043873 name: pyruvate-flavodoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin." [PMID:6352705] subset: gosubset_prok synonym: "NifJ" RELATED [] synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT [] xref: EC:1.2.7.- xref: MetaCyc:PYFLAVOXRE-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043874 name: acireductone synthase activity namespace: molecular_function def: "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77] comment: This function is involved in the process of methionine salvage. subset: gosubset_prok synonym: "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)" EXACT [EC:3.1.3.77] synonym: "E-1" RELATED [] synonym: "E-1 enolase-phosphatase" BROAD [] xref: EC:3.1.3.77 xref: MetaCyc:3.1.3.77-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043875 name: 2-ketobutyrate formate-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN, PMID:9484901] comment: This function is part of an anaerobic pathway for the catabolism of L-threonine. subset: gosubset_prok synonym: "keto-acid formate acetyltransferase" BROAD [] synonym: "KFL" EXACT [] synonym: "TdcE" RELATED [] xref: EC:2.3.1- xref: MetaCyc:KETOBUTFORMLY-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043876 name: D-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde." [MetaCyc:4.1.2.42-RXN, PMID:9642221] subset: gosubset_prok synonym: "D-allo-TA" EXACT [] synonym: "D-allo-threonine aldolase activity" EXACT [] synonym: "D-TA" EXACT [] synonym: "DtaAS" RELATED [] synonym: "low-specificity D-threonine aldolase" NARROW [] xref: EC:4.1.2.- xref: MetaCyc:4.1.2.42-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0043877 name: galactosamine-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3." [PMID:10931310] comment: This function is part of the pathway of N-acetyl-galactosamine and galactosamine utilization. subset: gosubset_prok synonym: "AgaI" RELATED [] synonym: "galactosamine-6-phosphate deaminase activity" EXACT [] xref: EC:5.3.1.- is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0043878 name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+." [PMID:9497334] subset: gosubset_prok synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity" EXACT [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) activity" EXACT [] synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT [] xref: EC:1.2.1.- xref: MetaCyc:RXN-3443 is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: GO:0043879 name: glycolate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)." [CHEBI:28905, GOC:jl] subset: gosubset_prok synonym: "glcA" RELATED [] synonym: "glycolate permease" RELATED [] synonym: "glycolic acid transmembrane transporter activity" EXACT [] synonym: "hydroxyacetic acid transmembrane transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity [Term] id: GO:0043880 name: crotonyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reduction of crotonyl-CoA to butyryl-CoA." [InterPro:IPR010085, PMID:11162231] subset: gosubset_prok synonym: "CCR" EXACT [] synonym: "crotonyl-coenzyme A reductase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043881 name: mesaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA." [PMID:16856935, PMID:16856937] comment: This function is part of an alternate glyoxylate cycle for acetate assimilation. subset: gosubset_prok synonym: "beta-methylmalyl-CoA dehydratase activity" EXACT [] synonym: "mch" RELATED [] synonym: "mesaconyl-coenzyme A hydratase activity" EXACT [] is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043882 name: malate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)." [GOC:jl, PMID:10903309] subset: gosubset_prok synonym: "malate Na(+) symporter activity" EXACT [] synonym: "malate-sodium symporter activity" EXACT [] synonym: "malate/sodium cotransporter activity" BROAD [] synonym: "malate/sodium symporter activity" EXACT [] synonym: "malate:Na+ symporter activity" EXACT [] synonym: "malate:sodium cotransporter activity" BROAD [] synonym: "Na(+)-malate symporter activity" EXACT [] synonym: "Na+:malate symporter activity" EXACT [] synonym: "sodium-dependent malate transporter" BROAD [] synonym: "sodium/malate symporter activity" EXACT [] synonym: "sodium:malate symporter activity" EXACT [] is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015140 ! malate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0043883 name: malolactic enzyme activity namespace: molecular_function def: "Catalysis of the reaction: malate + H+ = L-lactate + CO2." [MetaCyc:RXN8E-5623, PMID:3139053] comment: This function is part of the process of degradation of L-malic acid by lactic acid bacteria. subset: gosubset_prok synonym: "MleS" RELATED [] xref: EC:1.-.-.- is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043884 name: CO-methylating acetyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA." [EC:2.3.1.169, PMID:1748656] subset: gosubset_prok synonym: "acetyl-CoA synthase activity" BROAD [] synonym: "acetyl-CoA:corrinoid protein O-acetyltransferase activity" EXACT [] synonym: "ACS" RELATED [EC:2.3.1.169] synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT [] xref: EC:2.3.1.169 xref: MetaCyc:ACETYLSYNCLTH-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043885 name: carbon-monoxide dehydrogenase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin." [EC:1.2.7.4] subset: gosubset_prok synonym: "carbon monoxide dehydrogenase (ferredoxin) activity" EXACT [] synonym: "carbon monoxide dehydrogenase activity" BROAD [] synonym: "carbon-monoxide dehydrogenase activity" BROAD [EC:1.2.7.4] synonym: "carbon-monoxide,water:ferredoxin oxidoreductase activity" EXACT [] synonym: "carbon-monoxide:(acceptor) oxidoreductase activity" EXACT [] synonym: "CO dehydrogenase activity" EXACT [] synonym: "CO-dehydrogenase (ferredoxin) activity" EXACT [] synonym: "CO-dehydrogenase activity" EXACT [] synonym: "CODH" RELATED [] xref: EC:1.2.7.4 xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043886 name: structural constituent of carboxysome namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide." [GOC:jl] subset: gosubset_prok is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0043887 name: melibiose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)." [PMID:1970646] subset: gosubset_prok synonym: "MelB" RELATED [] synonym: "melibiose carrier protein" RELATED [] synonym: "melibiose permease" BROAD [] synonym: "melibiose-Na+ symporter activity" EXACT [] synonym: "melibiose-sodium symporter activity" EXACT [] synonym: "melibiose/Na+ symporter activity" EXACT [] synonym: "melibiose/sodium symporter activity" EXACT [] synonym: "melibiose:Na+ symporter activity" EXACT [] synonym: "Na+ (Li+)/melibiose symporter activity" EXACT [] synonym: "Na+-melibiose symporter activity" EXACT [] synonym: "Na+/melibiose symporter activity" EXACT [] synonym: "Na+:melibiose symporter activity" EXACT [] synonym: "sodium-melibiose symporter activity" EXACT [] synonym: "sodium/melibiose symporter activity" EXACT [] synonym: "sodium:melibiose symporter activity" EXACT [] synonym: "thiomethylgalactoside permease II" RELATED [] is_a: GO:0015487 ! melibiose:monovalent cation symporter activity [Term] id: GO:0043888 name: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity namespace: molecular_function def: "Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate." [PMID:15356000, PMID:16494480] comment: This function is involved in archaeal lipid synthesis. subset: gosubset_prok synonym: "2,3-dGGGPS" EXACT [] synonym: "DGGGP synthase activity" EXACT [] synonym: "DGGGPS" EXACT [] synonym: "UbiA" RELATED [] xref: EC:2.5.1.- is_a: GO:0002094 ! polyprenyltransferase activity is_a: GO:0004337 ! geranyltranstransferase activity [Term] id: GO:0043889 name: (S)-3-O-geranylgeranylglyceryl phosphate synthase activity namespace: molecular_function def: "Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate." [PMID:12801917, PMID:17253090, PMID:8408023] comment: This function is involved in archaeal lipid synthesis. subset: gosubset_prok synonym: "(S)-3-O-geranylgeranylglycerylphosphate synthase activity" EXACT [] synonym: "(S)-GGGP synthase activity" EXACT [] synonym: "GGGP synthase activity" EXACT [] synonym: "GGGPS" EXACT [] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0043890 name: N-acetylgalactosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate." [EC:3.1.6.4] subset: gosubset_prok synonym: "acetylgalactosamine 6-sulfatase activity" EXACT [] synonym: "chondroitin sulfatase" BROAD [] synonym: "chondroitinase" BROAD [] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.4] synonym: "galactose-6-sulfate sulfatase activity" EXACT [] synonym: "N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [] synonym: "N-acetylgalactosamine 6-sulfatase activity" EXACT [] synonym: "N-acetylgalactosamine-6-sulfate sulfatase activity" EXACT [] xref: EC:3.1.6.4 xref: MetaCyc:3.1.6.4-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0043891 name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." [EC:1.2.1.59] subset: gosubset_prok synonym: "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)" EXACT [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)" EXACT [] synonym: "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.59] synonym: "triosephosphate dehydrogenase (NAD(P))" EXACT [] synonym: "triosephosphate dehydrogenase (NAD(P)+)" EXACT [EC:1.2.1.59] xref: EC:1.2.1.59 xref: MetaCyc:GAPDHSYNEC-RXN is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: GO:0043892 name: methylglyoxal reductase (NADPH-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+." [EC:1.1.1.283] subset: gosubset_prok synonym: "Gre2" RELATED [] synonym: "lactaldehyde dehydrogenase (NADP+)" EXACT [] synonym: "lactaldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.283] xref: EC:1.1.1.283 xref: MetaCyc:1.1.1.283-RXN xref: MetaCyc:RXN-8636 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0043893 name: acetate:cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)." [GOC:jl] subset: gosubset_prok synonym: "acetate permease" BROAD [] synonym: "acetate-cation symporter activity" EXACT [] synonym: "acetate/cation symporter activity" EXACT [] synonym: "ActP" RELATED [] synonym: "cation-acetate symporter activity" EXACT [] synonym: "cation/acetate symporter activity" EXACT [] synonym: "cation:acetate symporter activity" EXACT [] is_a: GO:0015123 ! acetate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0043894 name: acetyl-CoA synthetase acetyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate." [PMID:15236963] subset: gosubset_prok synonym: "Pat" RELATED [] synonym: "Pat enzyme" EXACT [] synonym: "protein acetyltransferase activity" BROAD [] is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0043895 name: cyclomaltodextrin glucanotransferase activity namespace: molecular_function def: "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond." [EC:2.4.1.19] synonym: "1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)" EXACT [] synonym: "alpha-1,4-glucan 4-glycosyltransferase, cyclizing" RELATED [] synonym: "alpha-cyclodextrin glucanotransferase" RELATED [] synonym: "alpha-cyclodextrin glycosyltransferase" RELATED [] synonym: "Bacillus macerans amylase" RELATED [] synonym: "beta-cyclodextrin glucanotransferase" RELATED [] synonym: "beta-cyclodextrin glycosyltransferase" RELATED [] synonym: "BMA" RELATED [] synonym: "CGTase" RELATED [] synonym: "cyclodextrin glucanotransferase" BROAD [] synonym: "cyclodextrin glycosyltransferase" RELATED [] synonym: "cyclomaltodextrin glucotransferase" RELATED [] synonym: "cyclomaltodextrin glycosyltransferase" RELATED [] synonym: "gamma-cyclodextrin glycosyltransferase" RELATED [] synonym: "konchizaimu" RELATED [] synonym: "neutral-cyclodextrin glycosyltransferase" RELATED [] xref: EC:2.4.1.19 xref: MetaCyc:2.4.1.19-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0043896 name: glucan 1,6-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in 1,6-alpha-D-glucans and derived oligosaccharides." [EC:3.2.1.70] subset: gosubset_prok synonym: "exo-1,6-alpha-glucosidase activity" EXACT [EC:3.2.1.70] synonym: "exo-1,6-beta-glucosidase" RELATED [] synonym: "glucan alpha-1,6-D-glucohydrolase activity" EXACT [EC:3.2.1.70] synonym: "glucan-1,6-alpha-glucosidase activity" EXACT [] synonym: "glucodextranase activity" EXACT [EC:3.2.1.70] synonym: "glucodextrinase" BROAD [] xref: EC:3.2.1.70 xref: MetaCyc:3.2.1.70-RXN is_a: GO:0004558 ! alpha-glucosidase activity [Term] id: GO:0043897 name: glucan 1,4-alpha-maltohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains." [EC:3.2.1.133] subset: gosubset_prok synonym: "1,4-alpha-D-glucan alpha-maltohydrolase activity" EXACT [] synonym: "glucan-1,4-alpha-maltohydrolase activity" EXACT [] synonym: "maltogenic alpha-amylase activity" EXACT [] xref: EC:3.2.1.133 xref: MetaCyc:3.2.1.133-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0043898 name: 2,3-dihydroxybiphenyl 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid." [GOC:jl, PMID:15715866] subset: gosubset_prok synonym: "2,3-dihydroxybiphenyl-1,2-dioxygenase activity" EXACT [] synonym: "BphC" RELATED [] is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0043899 name: phosphoserine:homoserine phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine." [GOC:jl, PMID:14699121] subset: gosubset_prok synonym: "thrH" RELATED [] xref: EC:2.7.1.- xref: IMG:02616 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043900 name: regulation of multi-organism process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0051704 ! multi-organism process [Term] id: GO:0043901 name: negative regulation of multi-organism process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0051704 ! multi-organism process [Term] id: GO:0043902 name: positive regulation of multi-organism process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0051704 ! multi-organism process [Term] id: GO:0043903 name: regulation of symbiosis, encompassing mutualism through parasitism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0043904 name: isochorismate pyruvate lyase activity namespace: molecular_function def: "Catalysis of the reaction: isochorismate = salicylate + pyruvate." [GOC:jl, PMID:16248620] subset: gosubset_prok synonym: "IPL" EXACT [] synonym: "isochorismate-pyruvate lyase activity" EXACT [] xref: EC:4.1.3.- xref: IMG:02661 xref: MetaCyc:RXN-1981 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0043905 name: Ser-tRNA(Thr) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)." [GOC:jl, PMID:15240874] subset: gosubset_prok synonym: "Ser-tRNAThr hydrolase activity" EXACT [] xref: EC:3.1.1.- xref: IMG:02667 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0043906 name: Ala-tRNA(Pro) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)." [GOC:jl, PMID:14663147] subset: gosubset_prok synonym: "Ala-tRNAPro hydrolase activity" EXACT [] xref: EC:3.1.1.- xref: IMG:02668 is_a: GO:0002161 ! aminoacyl-tRNA editing activity [Term] id: GO:0043907 name: Cys-tRNA(Pro) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)." [GOC:jl, PMID:15886196] subset: gosubset_prok synonym: "Cys-tRNA(Pro) deacetylase activity" EXACT [] synonym: "Cys-tRNAPro hydrolase activity" EXACT [] xref: EC:3.1.1.- xref: IMG:02669 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0043908 name: Ser(Gly)-tRNA(Ala) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)." [GOC:jl, PMID:14663147] subset: gosubset_prok synonym: "Ser(Gly)-tRNAAla hydrolase activity" EXACT [] xref: EC:3.1.1.- xref: IMG:02670 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0043909 name: N-acetylcitrulline deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate." [GOC:jl, IMG:02799, PMID:16750290] subset: gosubset_prok synonym: "acetylcitrulline deacetylase activity" EXACT [] synonym: "N-acetyl-L-citrulline deacetylase activity" EXACT [] xref: EC:3.5.1.- xref: IMG:02799 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043910 name: coenzyme F390 synthetase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme F420 + ATP = coenzyme F390." [GOC:jl, IMG:02803, PMID:7957247, PMID:8550473] subset: gosubset_prok synonym: "ATP:coenzyme F420 adenyltransferase activity" EXACT [] xref: EC:2.7.7.- xref: IMG:02803 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0043911 name: D-lysine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate." [GOC:jl, IMG:02956, PMID:17259313] subset: gosubset_prok synonym: "D-lysine aminotransferase activity" EXACT [] xref: EC:2.6.1.- xref: IMG:02956 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043912 name: D-lysine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide." [GOC:jl, IMG:02957, PMID:17259313] subset: gosubset_prok xref: EC:1.4.3.- xref: IMG:02957 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0043913 name: chromosome segregation-directing complex namespace: cellular_component def: "A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology." [GOC:jl, PMID:15612918] subset: gosubset_prok synonym: "chromosome segregation directing complex" EXACT [] synonym: "longitudinal peptidoglycan synthesis-directing complex" EXACT [] synonym: "MreBCD complex" NARROW [] xref: IMG:02994 is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part [Term] id: GO:0043914 name: NADPH:sulfur oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + S0 = hydrogen sulfide + NADP." [GOC:jl, PMID:17449625] subset: gosubset_prok synonym: "CoA-dependent NAD(P)H sulfur oxidoreductase activity" EXACT [] synonym: "coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity" EXACT [] synonym: "NAD(P)H elemental sulfur oxidoreductase activity" EXACT [] synonym: "NAD(P)H sulfur oxidoreductase activity" EXACT [] synonym: "NAD(P)H sulphur oxidoreductase activity" EXACT [] synonym: "NAD(P)H:sulfur oxidoreductase activity" EXACT [] synonym: "NADPH:sulphur oxidoreductase activity" EXACT [] synonym: "NSR" EXACT [] xref: EC:1.-.-.- xref: IMG:03008 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043915 name: L-seryl-tRNA(Sec) kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)." [GOC:jl, IMG:03019, PMID:16201757] subset: gosubset_prok synonym: "O-phosphoseryl-tRNA(Sec) kinase activity" EXACT [] xref: EC:2.7.1.- xref: IMG:03019 xref: MetaCyc:RXN-10038 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043916 name: DNA-7-methylguanine glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes the alkylated base 7-methylguanine." [GOC:jl, PMID:16468998] subset: gosubset_prok xref: EC:3.2.2.- xref: IMG:03021 is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity [Term] id: GO:0043917 name: ribose 1,5-bisphosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate." [GOC:jl, IMG:03024] subset: gosubset_prok synonym: "ribose-1,5-bisphosphate isomerase activity" EXACT [] xref: EC:5.3.1.- xref: IMG:03024 xref: MetaCyc:RXN-8801 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0043918 name: cadaverine aminopropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine." [GOC:jl, IMG:00522, PMID:17545282] subset: gosubset_prok synonym: "cadaverine aminopropyl transferase activity" EXACT [] xref: EC:2.5.1.- xref: IMG:00522 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0043919 name: agmatine aminopropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine." [GOC:jl, IMG:03077, PMID:15983049] subset: gosubset_prok synonym: "agmatine aminopropyl transferase activity" EXACT [] xref: EC:2.5.1.- xref: IMG:03077 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0043920 name: aminopropylagmatine ureohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea." [GOC:jl, IMG:03079, PMID:15983049] subset: gosubset_prok xref: EC:3.5.3.- xref: IMG:03079 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0043921 name: modulation by host of viral transcription namespace: biological_process def: "Any process in which a host organism modulates the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl] synonym: "regulation by host of viral transcription" EXACT [] synonym: "regulation of viral transcription by host " EXACT [] is_a: GO:0046782 ! regulation of viral transcription is_a: GO:0052472 ! modulation by host of symbiont transcription [Term] id: GO:0043922 name: negative regulation by host of viral transcription namespace: biological_process def: "Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl] synonym: "negative regulation of viral transcription by host" EXACT [] is_a: GO:0032897 ! negative regulation of viral transcription is_a: GO:0043921 ! modulation by host of viral transcription [Term] id: GO:0043923 name: positive regulation by host of viral transcription namespace: biological_process def: "Any process is which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl] synonym: "positive regulation of viral transcription by host" EXACT [] is_a: GO:0043921 ! modulation by host of viral transcription is_a: GO:0050434 ! positive regulation of viral transcription [Term] id: GO:0043924 name: suramin binding namespace: molecular_function def: "Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [CHEBI:45906, GOC:jl, Wikipedia:Suramin] synonym: "Germanin binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0043927 name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:mtg_mpo] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic relationship: part_of GO:0000294 ! nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [Term] id: GO:0043928 name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo] xref: Reactome:1253756 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1253760 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1280688 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1280691 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1299514 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1327276 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1353369 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1353372 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1373542 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1373545 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1393561 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1393564 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1418063 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1418066 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1451154 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1451158 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1471500 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1471503 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1483436 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1483440 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1497080 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1497084 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1514467 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1514471 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1521338 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1521342 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1527036 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1527040 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1532769 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:1532773 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:1536147 "mRNA Decay by 5' to 3' Exoribonuclease" xref: Reactome:429958 "mRNA Decay by 3' to 5' Exoribonuclease" xref: Reactome:430039 "mRNA Decay by 5' to 3' Exoribonuclease" is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0043929 name: primary ovarian follicle growth involved in double layer follicle stage namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), as part of the double layer follicle stage of oogenesis." [GOC:mtg_mpo] synonym: "primary ovarian follicle growth during double layer follicle stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001545 ! primary ovarian follicle growth relationship: part_of GO:0048161 ! double layer follicle stage [Term] id: GO:0043930 name: primary ovarian follicle growth involved in primary follicle stage namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) as part of the primary follicle stage of oogenesis." [GOC:mtg_mpo] synonym: "primary ovarian follicle growth during primary follicle stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001545 ! primary ovarian follicle growth relationship: part_of GO:0048160 ! primary follicle stage [Term] id: GO:0043931 name: ossification involved in bone maturation namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo] synonym: "ossification involved in skeletal development" EXACT [GOC:dph] is_a: GO:0001503 ! ossification relationship: part_of GO:0070977 ! bone maturation [Term] id: GO:0043932 name: ossification involved in bone remodeling namespace: biological_process def: "The formation of bone involved in the continuous turnover of bone matrix and mineral." [GOC:mtg_mpo] synonym: "ossification involved in bone remodelling" RELATED [] is_a: GO:0001503 ! ossification relationship: part_of GO:0046849 ! bone remodeling [Term] id: GO:0043933 name: macromolecular complex subunit organization namespace: biological_process alt_id: GO:0034600 def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex." [GOC:mtg_mpo] subset: gosubset_prok synonym: "macromolecular complex organization" EXACT [] synonym: "macromolecular complex subunit organisation" EXACT [GOC:curators] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0043934 name: sporulation namespace: biological_process def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] xref: Wikipedia:Spore is_a: GO:0032502 ! developmental process [Term] id: GO:0043935 name: sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0034293 ! sexual sporulation [Term] id: GO:0043936 name: asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0030436 ! asexual sporulation [Term] id: GO:0043937 name: regulation of sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0043934 ! sporulation [Term] id: GO:0043938 name: positive regulation of sporulation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0043934 ! sporulation [Term] id: GO:0043939 name: negative regulation of sporulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0043934 ! sporulation [Term] id: GO:0043940 name: regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0034306 ! regulation of sexual sporulation is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore relationship: regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043941 name: positive regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043942 name: negative regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043943 name: regulation of asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] is_a: GO:0034305 ! regulation of asexual sporulation is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore relationship: regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043944 name: negative regulation of asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore relationship: negatively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043945 name: positive regulation of asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore relationship: positively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043946 name: positive regulation of catalytic activity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "activation of enzyme activity in other organism" NARROW [] synonym: "activation of enzyme activity in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation of catalytic activity in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "up regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "upregulation of enzyme activity in other organism during symbiotic interaction" RELATED [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0043947 name: positive regulation by host of symbiont catalytic activity namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "activation by host of symbiont enzyme activity" NARROW [] synonym: "activation of symbiont enzyme activity" NARROW [] synonym: "positive regulation by host of symbiont enzyme activity" EXACT [] synonym: "up regulation by host of symbiont enzyme activity" EXACT [] synonym: "up-regulation by host of symbiont enzyme activity" EXACT [] synonym: "upregulation by host of symbiont enzyme activity" EXACT [] is_a: GO:0043946 ! positive regulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052405 ! negative regulation by host of symbiont molecular function is_a: GO:0052422 ! modulation by host of symbiont catalytic activity [Term] id: GO:0043948 name: positive regulation by symbiont of host catalytic activity namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host enzyme activity" NARROW [] synonym: "activation of host enzyme activity" NARROW [] synonym: "positive regulation by symbiont of host enzyme activity" EXACT [] synonym: "up regulation by symbiont of host enzyme activity" EXACT [] synonym: "up-regulation by symbiont of host enzyme activity" EXACT [] synonym: "upregulation by symbiont of host enzyme activity" EXACT [] is_a: GO:0043946 ! positive regulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052056 ! negative regulation by symbiont of host molecular function is_a: GO:0052148 ! modulation by symbiont of host catalytic activity [Term] id: GO:0043949 name: regulation of cAMP-mediated signaling namespace: biological_process def: "Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] synonym: "regulation of cAMP-mediated signalling" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0019933 ! cAMP-mediated signaling [Term] id: GO:0043950 name: positive regulation of cAMP-mediated signaling namespace: biological_process def: "Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] synonym: "positive regulation of cAMP-mediated signalling" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043949 ! regulation of cAMP-mediated signaling relationship: positively_regulates GO:0019933 ! cAMP-mediated signaling [Term] id: GO:0043951 name: negative regulation of cAMP-mediated signaling namespace: biological_process def: "Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] synonym: "negative regulation of cAMP-mediated signalling" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043949 ! regulation of cAMP-mediated signaling relationship: negatively_regulates GO:0019933 ! cAMP-mediated signaling [Term] id: GO:0043952 name: protein transport by the Sec complex namespace: biological_process def: "The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'cell envelope Sec protein transport complex ; GO:0031522'. For proteins involved in bacterial Type II secretion across the outer membrane, consider annotating to 'protein secretion by the Type II secretion system ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'SRP-dependent cotranslational protein targeting to membrane, translocation ; GO:0006616'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. synonym: "protein secretion by the Sec complex" NARROW [] synonym: "protein translocation by the Sec complex" NARROW [] is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0043953 name: protein transport by the Tat complex namespace: biological_process def: "The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'TAT protein translocation system complex ; GO:0033281'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. subset: gosubset_prok synonym: "protein secretion by the TAT complex" NARROW [] synonym: "protein translocation by the TAT complex" NARROW [] synonym: "protein translocation by the Twin-arginine translocation complex" NARROW [] is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0043954 name: cellular component maintenance namespace: biological_process def: "The organization process that preserves a cellular component in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0043955 name: 3-hydroxypropionyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate." [GOC:jl, PMID:11821399] comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. subset: gosubset_prok synonym: "3-hydroxy propionyl-CoA synthetase activity" EXACT [] synonym: "acetyl-coenzyme A synthetase" BROAD [] synonym: "acetyl-coenzyme A synthetase/GroES-like domain" NARROW [] synonym: "AMP-dependent synthetase and ligase" BROAD [] synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD [] synonym: "enoyl-CoA hydratase/isomerase" BROAD [] xref: EC:6.2.1.- xref: IMG:03293 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0043956 name: 3-hydroxypropionyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O." [GOC:jl, PMID:11821399] comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. subset: gosubset_prok synonym: "3-hydroxy propionyl-CoA dehydratase activity" EXACT [] synonym: "acetyl-coenzyme A synthetase" BROAD [] synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD [] synonym: "AMP-dependent synthetase and ligase" BROAD [] synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD [] synonym: "enoyl-CoA hydratase/isomerase" BROAD [] xref: EC:4.2.1.- xref: IMG:03294 xref: MetaCyc:RXN-6383 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043957 name: acrylyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: acrylyl-CoA + NADPH + H+ = propionyl-CoA + NADP+." [GOC:jl, PMID:11821399] comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. subset: gosubset_prok synonym: "acetyl-coenzyme A synthetase" BROAD [] synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD [] synonym: "AMP-dependent synthetase and ligase" BROAD [] synonym: "AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase" BROAD [] synonym: "enoyl-CoA hydratase/isomerase" BROAD [] xref: EC:1.3.1.- xref: IMG:03302 xref: MetaCyc:RXN-9087 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0043958 name: acryloyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced electron transferring flavoprotein + NADH + acrylyl-CoA = NAD+ + oxidized electron transferring flavoprotein + propionyl-CoA." [GOC:jl, PMID:12603323] comment: Note that this function is part of the process of L-alanine fermentation to propionate. subset: gosubset_prok synonym: "acryloyl-coenzyme A reductase activity" EXACT [] synonym: "acrylyl-CoA reductase (NADH)" EXACT [] synonym: "propionyl-CoA dehydrogenase" EXACT [] xref: EC:1.3.1.- xref: IMG:01636 xref: MetaCyc:CPLX-7247 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0043959 name: L-erythro-3-methylmalyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA." [GOC:jl, IMG:03303] subset: gosubset_prok synonym: "HpcH/HpaI aldolase" RELATED [] xref: EC:4.1.3.- xref: IMG:03303 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0043960 name: L-erythro-3-methylmalyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O." [GOC:jl, IMG:03304] subset: gosubset_prok xref: EC:4.2.1.- xref: IMG:03304 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043961 name: succinyl-CoA:(R)-citramalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA." [GOC:jl, IMG:03306, PMID:17259315] subset: gosubset_prok synonym: "L-carnitine dehydratase/bile acid-inducible protein F" RELATED [] synonym: "succinyl-CoA:(R)-citramalate CoA transferase activity" EXACT [] synonym: "succinyl-CoA:R-citramalate CoA transferase" EXACT [] xref: EC:2.8.3.- xref: IMG:03306 xref: MetaCyc:RXN-8966 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0043962 name: negative regulation by host of symbiont adenylate cyclase-mediated signal transduction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075336". is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway is_a: GO:0075332 ! modulation by host of symbiont adenylate cyclase-mediated signal transduction [Term] id: GO:0043963 name: modulation by symbiont of host adenylate cyclase-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0043964 name: positive regulation by symbiont of host adenylate cyclase-mediated signal transduction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway [Term] id: GO:0043965 name: negative regulation by symbiont of host adenylate cyclase-mediated signal transduction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway [Term] id: GO:0043966 name: histone H3 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation [Term] id: GO:0043967 name: histone H4 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation [Term] id: GO:0043968 name: histone H2A acetylation namespace: biological_process def: "The modification of histone H2A by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation [Term] id: GO:0043969 name: histone H2B acetylation namespace: biological_process def: "The modification of histone H2B by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation [Term] id: GO:0043970 name: histone H3-K9 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K9" EXACT [] synonym: "histone H3K9 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043971 name: histone H3-K18 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K18" EXACT [] synonym: "histone H3K18 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043972 name: histone H3-K23 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K23" EXACT [] synonym: "histone H3K23 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043973 name: histone H3-K4 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K4" EXACT [] synonym: "histone H3K4 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043974 name: histone H3-K27 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K27" EXACT [] synonym: "histone H3K27 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043975 name: histone H3-K36 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K36" EXACT [] synonym: "histone H3K36 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043976 name: histone H3-K79 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K79" EXACT [] synonym: "histone H3K79 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043977 name: histone H2A-K5 acetylation namespace: biological_process def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl] synonym: "histone H2A acetylation at K5" EXACT [] is_a: GO:0043968 ! histone H2A acetylation [Term] id: GO:0043978 name: histone H2A-K9 acetylation namespace: biological_process def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl] synonym: "histone H2A acetylation at K9" EXACT [] is_a: GO:0043968 ! histone H2A acetylation [Term] id: GO:0043979 name: histone H2B-K5 acetylation namespace: biological_process def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl] synonym: "histone H2B acetylation at K5" EXACT [] is_a: GO:0043969 ! histone H2B acetylation [Term] id: GO:0043980 name: histone H2B-K12 acetylation namespace: biological_process def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl] synonym: "histone H2B acetylation at K12" EXACT [] is_a: GO:0043969 ! histone H2B acetylation [Term] id: GO:0043981 name: histone H4-K5 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl] synonym: "histone H4 acetylation at K5" EXACT [] is_a: GO:0043967 ! histone H4 acetylation [Term] id: GO:0043982 name: histone H4-K8 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone." [GOC:jl] synonym: "histone H4 acetylation at K8" EXACT [] is_a: GO:0043967 ! histone H4 acetylation [Term] id: GO:0043983 name: histone H4-K12 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl] synonym: "histone H4 acetylation at K12" EXACT [] is_a: GO:0043967 ! histone H4 acetylation [Term] id: GO:0043984 name: histone H4-K16 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl] synonym: "histone H4 acetylation at K16" EXACT [] is_a: GO:0043967 ! histone H4 acetylation [Term] id: GO:0043985 name: histone H4-R3 methylation namespace: biological_process def: "The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone." [GOC:mah] synonym: "histone H4 methylation at R3" EXACT [] synonym: "histone H4 R3 methylation" EXACT [] synonym: "histone H4R3me" EXACT [] is_a: GO:0034969 ! histone arginine methylation [Term] id: GO:0043987 name: histone H3-S10 phosphorylation namespace: biological_process alt_id: GO:0043986 def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl] synonym: "histone H3 phosphorylation at S10" EXACT [] synonym: "histone H3S10 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0043988 name: histone H3-S28 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone." [GOC:jl] synonym: "histone H3 phosphorylation at S28" EXACT [] synonym: "histone H3S28 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0043989 name: histone H4-S1 phosphorylation namespace: biological_process def: "The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl] synonym: "histone H4 phosphorylation at S1" EXACT [] synonym: "histone H4S1 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0043990 name: histone H2A-S1 phosphorylation namespace: biological_process def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl] synonym: "histone H2A phosphorylation at S1" EXACT [] synonym: "histone H2AS1 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0043991 name: histone H2B-S14 phosphorylation namespace: biological_process def: "The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone." [GOC:jl] synonym: "histone H2B phosphorylation at S14" EXACT [] synonym: "histone H2BS14 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0043992 name: histone acetyltransferase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K9 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0043993 name: histone acetyltransferase activity (H3-K18 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K18 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0043994 name: histone acetyltransferase activity (H3-K23 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K23 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0043995 name: histone acetyltransferase activity (H4-K5 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H4-K5 specific)" EXACT [] is_a: GO:0010485 ! H4 histone acetyltransferase activity [Term] id: GO:0043996 name: histone acetyltransferase activity (H4-K8 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H4-K8 specific)" EXACT [] is_a: GO:0010485 ! H4 histone acetyltransferase activity [Term] id: GO:0043997 name: histone acetyltransferase activity (H4-K12 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H4-K12 specific)" EXACT [] is_a: GO:0010485 ! H4 histone acetyltransferase activity [Term] id: GO:0043998 name: H2A histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine." [EC:2.3.1.48] synonym: "H2A histone lysine N-acetyltransferase activity" EXACT [] is_a: GO:0004402 ! histone acetyltransferase activity [Term] id: GO:0043999 name: histone acetyltransferase activity (H2A-K5 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H2A-K5 specific)" EXACT [] is_a: GO:0043998 ! H2A histone acetyltransferase activity [Term] id: GO:0044000 name: movement in host namespace: biological_process def: "The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "movement of symbiont in host" EXACT [] synonym: "movement of symbiont within host" EXACT [] synonym: "movement within host" EXACT [] synonym: "symbiont movement in host" EXACT [] synonym: "symbiont movement within host" RELATED [] is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction is_a: GO:0052126 ! movement in host environment [Term] id: GO:0044001 name: migration in host namespace: biological_process def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "migration within host" EXACT [] is_a: GO:0044000 ! movement in host is_a: GO:0051815 ! migration in other organism involved in symbiotic interaction [Term] id: GO:0044002 name: acquisition of nutrients from host namespace: biological_process def: "The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl] subset: gosubset_prok is_a: GO:0051701 ! interaction with host is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction [Term] id: GO:0044003 name: modification by symbiont of host morphology or physiology namespace: biological_process def: "The process in which an organism effects a change in the structure or processes of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0051701 ! interaction with host is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0044004 name: disruption by symbiont of host cells namespace: biological_process def: "Any process in which an organism has a negative effect on the functioning of the host's cells. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "disruption by organism of host cells" EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0051818 ! disruption of cells of other organism involved in symbiotic interaction [Term] id: GO:0044005 name: induction by symbiont in host of tumor, nodule, or growth namespace: biological_process def: "The process in which an organism causes the formation of an abnormal mass of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0051819 ! induction of tumor, nodule, or growth in other organism involved in symbiotic interaction [Term] id: GO:0044006 name: induction by symbiont in host of tumor, nodule, or growth containing transformed cells namespace: biological_process def: "The process in which an organism causes the formation in its host organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] is_a: GO:0044005 ! induction by symbiont in host of tumor, nodule, or growth is_a: GO:0051820 ! induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction [Term] id: GO:0044007 name: dissemination or transmission of symbiont from host namespace: biological_process def: "The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "dissemination or transmission of organism from host" EXACT [] is_a: GO:0051701 ! interaction with host is_a: GO:0051821 ! dissemination or transmission of organism from other organism involved in symbiotic interaction [Term] id: GO:0044008 name: dissemination or transmission of symbiont from host by vector namespace: biological_process def: "The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "dissemination or transmission of organism from host by vector" EXACT [] is_a: GO:0044007 ! dissemination or transmission of symbiont from host is_a: GO:0051822 ! dissemination or transmission of organism from other organism by vector involved in symbiotic interaction [Term] id: GO:0044009 name: viral transmission by vector namespace: biological_process def: "The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection." [GOC:cc] is_a: GO:0019089 ! transmission of virus is_a: GO:0044008 ! dissemination or transmission of symbiont from host by vector [Term] id: GO:0044010 name: single-species biofilm formation namespace: biological_process def: "A process in which microorganisms of the same species attach to and grow on a surface such, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] subset: gosubset_prok is_a: GO:0042710 ! biofilm formation [Term] id: GO:0044011 name: single-species biofilm formation on inanimate substrate namespace: biological_process def: "A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] subset: gosubset_prok is_a: GO:0044010 ! single-species biofilm formation is_a: GO:0051703 ! intraspecies interaction between organisms [Term] id: GO:0044012 name: histone acetyltransferase activity (H2A-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H2A-K9 specific)" EXACT [] is_a: GO:0043998 ! H2A histone acetyltransferase activity [Term] id: GO:0044013 name: H2B histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine." [EC:2.3.1.48] synonym: "H2B histone lysine N-acetyltransferase activity" EXACT [] is_a: GO:0004402 ! histone acetyltransferase activity [Term] id: GO:0044014 name: histone acetyltransferase activity (H2B-K5 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H2B-K5 specific)" EXACT [] is_a: GO:0044013 ! H2B histone acetyltransferase activity [Term] id: GO:0044015 name: histone acetyltransferase activity (H2B-K12 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H2B-K12 specific)" EXACT [] is_a: GO:0044013 ! H2B histone acetyltransferase activity [Term] id: GO:0044016 name: histone acetyltransferase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K4 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0044017 name: histone acetyltransferase activity (H3-K27 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K27 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0044018 name: histone acetyltransferase activity (H3-K36 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K36 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0044019 name: histone acetyltransferase activity (H3-K72 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K72 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0044020 name: histone methyltransferase activity (H4-R3 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4." [EC:2.1.1.125, GOC:mah, PMID:17898714] synonym: "histone methylase activity (H4-R3 specific)" EXACT [GOC:mah] synonym: "histone-arginine N-methyltransferase activity (H4-R3 specific)" EXACT [] is_a: GO:0008469 ! histone-arginine N-methyltransferase activity [Term] id: GO:0044022 name: histone kinase activity (H3-S28 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3." [GOC:jl] synonym: "histone serine kinase activity (H3-S28 specific)" EXACT [] synonym: "histone-serine kinase activity (H3-S28 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity [Term] id: GO:0044023 name: histone kinase activity (H4-S1 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H4." [GOC:jl] synonym: "histone serine kinase activity (H4-S1 specific)" EXACT [] synonym: "histone-serine kinase activity (H4-S1 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity [Term] id: GO:0044024 name: histone kinase activity (H2A-S1 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A." [GOC:jl] synonym: "histone serine kinase activity (H2A-S1 specific)" EXACT [] synonym: "histone-serine kinase activity (H2A-S1 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity [Term] id: GO:0044025 name: histone kinase activity (H2B-S14 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-14 residue of the N-terminal tail of histone H2B." [GOC:jl] synonym: "histone serine kinase activity (H2B-S14 specific)" EXACT [] synonym: "histone-serine kinase activity (H2B-S14 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity [Term] id: GO:0044026 name: DNA hypermethylation namespace: biological_process def: "An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/] is_a: GO:0044030 ! regulation of DNA methylation [Term] id: GO:0044027 name: hypermethylation of CpG island namespace: biological_process def: "An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island] synonym: "DNA hypermethylation of CpG island" EXACT [] is_a: GO:0044026 ! DNA hypermethylation [Term] id: GO:0044028 name: DNA hypomethylation namespace: biological_process def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/hypomethylation] is_a: GO:0044030 ! regulation of DNA methylation [Term] id: GO:0044029 name: hypomethylation of CpG island namespace: biological_process def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island] synonym: "DNA hypomethylation of CpG island" EXACT [] is_a: GO:0044028 ! DNA hypomethylation [Term] id: GO:0044030 name: regulation of DNA methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:jl] is_a: GO:0051052 ! regulation of DNA metabolic process relationship: regulates GO:0006306 ! DNA methylation [Term] id: GO:0044031 name: modification by symbiont of host protein by phosphorylation namespace: biological_process def: "The process in which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that phosphorylate host proteins, consider annotation to 'protein amino acid phosphorylation ; GO:0006468'. Consider also annotation to the molecular function term 'protein kinase activity ; GO:0004672'. subset: gosubset_prok is_a: GO:0075345 ! modification by symbiont of host protein [Term] id: GO:0044032 name: modulation by symbiont of indole acetic acid levels in host namespace: biological_process def: "The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate indole acetic acid levels in the host, consider annotating to 'auxin homeostasis ; GO:0010252'. synonym: "modulation by symbiont of auxin levels in host" BROAD [] synonym: "modulation by symbiont of IAA levels in host" EXACT [] is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels [Term] id: GO:0044033 name: multi-organism metabolic process namespace: biological_process def: "Any metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism." [GOC:jl] subset: gosubset_prok synonym: "multi-organism metabolism" EXACT [] synonym: "multi-organismal metabolic process" EXACT [] synonym: "multi-organismal metabolism" EXACT [] is_a: GO:0008152 ! metabolic process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0044034 name: multi-organism biosynthetic process namespace: biological_process def: "Any biosynthetic process - chemical reactions and pathways resulting in the formation of substances - which involves more than one organism." [GOC:jl] subset: gosubset_prok synonym: "multi-organism biosynthesis" EXACT [] synonym: "multi-organismal biosynthesis" EXACT [] synonym: "multi-organismal biosynthetic process" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044033 ! multi-organism metabolic process [Term] id: GO:0044035 name: multi-organism catabolic process namespace: biological_process def: "Any catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves more than one organism." [GOC:jl] subset: gosubset_prok synonym: "multi-organism catabolism" EXACT [] synonym: "multi-organismal catabolic process" EXACT [] synonym: "multi-organismal catabolism" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044033 ! multi-organism metabolic process [Term] id: GO:0044036 name: cell wall macromolecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah] is_a: GO:0043170 ! macromolecule metabolic process relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0044037 name: multi-organism cell wall macromolecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall, involving more than one organism. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah, GOC:tair_curators] subset: gosubset_prok synonym: "multi-organism cell wall macromolecule metabolism" EXACT [GOC:mah] is_a: GO:0044033 ! multi-organism metabolic process is_a: GO:0044036 ! cell wall macromolecule metabolic process [Term] id: GO:0044038 name: cell wall macromolecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall." [GOC:go_curators] subset: gosubset_prok synonym: "cell wall macromolecule anabolism" EXACT [GOC:mah] synonym: "cell wall macromolecule biosynthesis" EXACT [GOC:mah] synonym: "cell wall macromolecule biosynthetic process at cellular level" EXACT [GOC:mah] synonym: "cell wall macromolecule synthesis" EXACT [GOC:mah] synonym: "cellular cell wall macromolecule biosynthetic process" EXACT [GOC:mah] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0070589 ! cellular component macromolecule biosynthetic process relationship: part_of GO:0042546 ! cell wall biogenesis [Term] id: GO:0044039 name: cellular cell wall macromolecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall, occurring at the level of the cell." [GOC:go_curators] subset: gosubset_prok synonym: "cellular cell wall macromolecule breakdown" EXACT [GOC:mah] synonym: "cellular cell wall macromolecule catabolism" EXACT [GOC:mah] synonym: "cellular cell wall macromolecule degradation" EXACT [GOC:mah] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0016998 ! cell wall macromolecule catabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0044040 name: multi-organism carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, that involve more than one organism." [GOC:jl] subset: gosubset_prok synonym: "main pathways of carbohydrate metabolic process" NARROW [] synonym: "main pathways of carbohydrate metabolism" NARROW [] synonym: "multi-organism carbohydrate metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044033 ! multi-organism metabolic process [Term] id: GO:0044041 name: multi-organism carbohydrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, involving more than one organism." [GOC:jl] subset: gosubset_prok synonym: "multi-organism carbohydrate breakdown" EXACT [] synonym: "multi-organism carbohydrate catabolism" EXACT [] synonym: "multi-organism carbohydrate degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044040 ! multi-organism carbohydrate metabolic process [Term] id: GO:0044042 name: glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] subset: gosubset_prok synonym: "glucan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0044043 name: multi-organism glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, involving more than one organism." [ISBN:0198547684] subset: gosubset_prok synonym: "multi-organism glucan metabolism" EXACT [] is_a: GO:0044040 ! multi-organism carbohydrate metabolic process is_a: GO:0044042 ! glucan metabolic process [Term] id: GO:0044044 name: interaction with host via substance in symbiont surface namespace: biological_process def: "An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] subset: gosubset_prok is_a: GO:0051701 ! interaction with host [Term] id: GO:0044045 name: interaction with host via substance in symbiont cell outer membrane namespace: biological_process def: "An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] subset: gosubset_prok is_a: GO:0044044 ! interaction with host via substance in symbiont surface [Term] id: GO:0044046 name: interaction with host via substance released outside of symbiont namespace: biological_process def: "An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis." [MITRE:tk] subset: gosubset_prok synonym: "interaction with host via substance released outside of symbiont cells" EXACT [] is_a: GO:0051701 ! interaction with host [Term] id: GO:0044047 name: interaction with host via protein secreted by type I secretion system namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type I secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] subset: gosubset_prok is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction [Term] id: GO:0044048 name: interaction with host via protein secreted by type V secretion system namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type V secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction [Term] id: GO:0044049 name: interaction with host via protein secreted by type VI secretion system namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type VI secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction [Term] id: GO:0044050 name: interaction with host via substance released by sporangium lysis namespace: biological_process def: "An interaction with the host organism mediated by a substance released via rupture of symbiont sporangia, structures producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] subset: gosubset_prok synonym: "interaction with host via substance released by lysis of symbiont sporangium" RELATED [] synonym: "interaction with host via substance released by sporangia lysis" EXACT [] is_a: GO:0044046 ! interaction with host via substance released outside of symbiont [Term] id: GO:0044051 name: interaction with host via substance released by symbiont cytolysis namespace: biological_process def: "An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] subset: gosubset_prok synonym: "interaction with host via substance released by cytolysis of symbiont" EXACT [] is_a: GO:0044046 ! interaction with host via substance released outside of symbiont [Term] id: GO:0044052 name: interaction with host via substance released by membrane budding namespace: biological_process def: "An interaction with the host organism mediated by a substance released via symbiont membrane budding, the evagination of a membrane resulting in formation of a vesicle." [MITRE:tk] subset: gosubset_prok synonym: "interaction with host via substance released by symbiont membrane budding" EXACT [] is_a: GO:0044046 ! interaction with host via substance released outside of symbiont [Term] id: GO:0044053 name: translocation of peptides or proteins into host cell cytoplasm namespace: biological_process def: "The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm." [MITRE:tk] subset: gosubset_prok synonym: "translocation of symbiont peptides or proteins into host cell cytoplasm" EXACT [] synonym: "transport of peptides or proteins into host cell cytoplasm" EXACT [] is_a: GO:0042000 ! translocation of peptides or proteins into host [Term] id: GO:0044054 name: rounding by symbiont of host cells namespace: biological_process def: "Any process in which an organism causes host cells to change shape and become round." [MITRE:tk] subset: gosubset_prok is_a: GO:0044004 ! disruption by symbiont of host cells [Term] id: GO:0044055 name: modulation by symbiont of host system process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a system process in the host. A system process is a multicellular organismal process carried out by any of the organs or tissues in an organ system." [MITRE:tk] subset: gosubset_prok synonym: "regulation by symbiont of host system process " EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0044057 ! regulation of system process [Term] id: GO:0044056 name: modulation by symbiont of host digestive system process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [MITRE:tk] synonym: "regulation by symbiont of host digestive system process" EXACT [] is_a: GO:0044055 ! modulation by symbiont of host system process is_a: GO:0044058 ! regulation of digestive system process [Term] id: GO:0044057 name: regulation of system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0003008 ! system process [Term] id: GO:0044058 name: regulation of digestive system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl] is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0022600 ! digestive system process [Term] id: GO:0044059 name: modulation by symbiont of host endocrine process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism." [MITRE:tk] subset: gosubset_prok synonym: "regulation by symbiont of host endocrine process" EXACT [] is_a: GO:0044055 ! modulation by symbiont of host system process is_a: GO:0044060 ! regulation of endocrine process [Term] id: GO:0044060 name: regulation of endocrine process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl] synonym: "regulation of endocrine system process" EXACT [] is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0050886 ! endocrine process [Term] id: GO:0044061 name: modulation by symbiont of host excretion namespace: biological_process def: "The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity." [MITRE:tk] subset: gosubset_prok synonym: "regulation by symbiont of host excretion " EXACT [] is_a: GO:0044055 ! modulation by symbiont of host system process is_a: GO:0044062 ! regulation of excretion [Term] id: GO:0044062 name: regulation of excretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl] is_a: GO:0044057 ! regulation of system process is_a: GO:0051046 ! regulation of secretion relationship: regulates GO:0007588 ! excretion [Term] id: GO:0044063 name: modulation by symbiont of host neurological system process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [MITRE:tk] subset: gosubset_prok synonym: "regulation by symbiont of host neurological system process" EXACT [] is_a: GO:0031644 ! regulation of neurological system process is_a: GO:0044055 ! modulation by symbiont of host system process [Term] id: GO:0044064 name: modulation by symbiont of host respiratory system process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [MITRE:tk] subset: gosubset_prok synonym: "regulation by symbiont of host respiratory system process " EXACT [] is_a: GO:0044055 ! modulation by symbiont of host system process is_a: GO:0044065 ! regulation of respiratory system process [Term] id: GO:0044065 name: regulation of respiratory system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0003016 ! respiratory system process [Term] id: GO:0044066 name: modification by symbiont of host cell nucleus namespace: biological_process def: "The process in which a symbiont organism effects a change in the structure or function of its host cell nucleus." [MITRE:tk] subset: gosubset_prok synonym: "modification by symbiont of host nucleus " EXACT [] synonym: "modification of host cell nucleus by symbiont" EXACT [] synonym: "modification of host nucleus by symbiont" EXACT [] is_a: GO:0052043 ! modification by symbiont of host cellular component [Term] id: GO:0044067 name: modification by symbiont of host intercellular junctions namespace: biological_process def: "The process in which a symbiont organism effects a change in the structure or function of its host intercellular junction, a specialized region of connection between two cells." [MITRE:tk] subset: gosubset_prok synonym: "modification of host intercellular junctions by symbiont " EXACT [] is_a: GO:0052043 ! modification by symbiont of host cellular component [Term] id: GO:0044068 name: modulation by symbiont of host cellular process namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism." [MITRE:tk] subset: gosubset_prok synonym: "modulation of host cellular process by symbiont" EXACT [] synonym: "regulation by symbiont of host cellular process " EXACT [] synonym: "regulation of host cellular process by symbiont" EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0044069 name: modification by symbiont of host anion transport namespace: biological_process def: "The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism." [MITRE:tk] subset: gosubset_prok synonym: "modification of host anion transport by symbiont" EXACT [] is_a: GO:0044070 ! regulation of anion transport is_a: GO:0052038 ! modulation by symbiont of host intracellular transport [Term] id: GO:0044070 name: regulation of anion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0043269 ! regulation of ion transport relationship: regulates GO:0006820 ! anion transport [Term] id: GO:0044071 name: modulation by symbiont of host cell cycle namespace: biological_process def: "The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery." [MITRE:tk] subset: gosubset_prok synonym: "modification by symbiont of host cell cycle " EXACT [] synonym: "modulation of host cell cycle by symbiont" EXACT [] synonym: "regulation by symbiont of host cell cycle " EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0051726 ! regulation of cell cycle [Term] id: GO:0044072 name: negative regulation by symbiont of host cell cycle namespace: biological_process def: "The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery." [MITRE:tk] subset: gosubset_prok is_a: GO:0044071 ! modulation by symbiont of host cell cycle is_a: GO:0045786 ! negative regulation of cell cycle [Term] id: GO:0044073 name: modulation by symbiont of host translation namespace: biological_process def: "The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk] subset: gosubset_prok synonym: "modification by symbiont of host translation" EXACT [] synonym: "modulation of host translation by symbiont" EXACT [] synonym: "regulation by symbiont of host translation" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0044068 ! modulation by symbiont of host cellular process [Term] id: GO:0044074 name: negative regulation by symbiont of host translation namespace: biological_process def: "The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk] subset: gosubset_prok synonym: "negative regulation of host translation by symbiont" EXACT [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0044073 ! modulation by symbiont of host translation [Term] id: GO:0044075 name: modulation by symbiont of host vacuole organization namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk] subset: gosubset_prok synonym: "modulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah] synonym: "modulation by symbiont of host vacuole organisation" EXACT [GOC:mah] synonym: "modulation of host vacuole organization by symbiont" EXACT [GOC:mah] synonym: "regulation by symbiont of host vacuole organization" EXACT [GOC:mah] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0044088 ! regulation of vacuole organization [Term] id: GO:0044076 name: positive regulation by symbiont of host vacuole organization namespace: biological_process def: "The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk] synonym: "positive regulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah] synonym: "positive regulation by symbiont of host vacuole organisation" EXACT [GOC:mah] synonym: "positive regulation of host vacuole organization by symbiont" EXACT [] is_a: GO:0044075 ! modulation by symbiont of host vacuole organization is_a: GO:0044090 ! positive regulation of vacuole organization [Term] id: GO:0044077 name: modulation by symbiont of host receptor-mediated endocytosis namespace: biological_process def: "The process in which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk] subset: gosubset_prok synonym: "modulation of host receptor-mediated endocytosis by symbiont" EXACT [] synonym: "regulation by symbiont of host receptor-mediated endocytosis" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0048259 ! regulation of receptor-mediated endocytosis [Term] id: GO:0044078 name: positive regulation by symbiont of host receptor-mediated endocytosis namespace: biological_process def: "Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk] subset: gosubset_prok synonym: "positive regulation of host receptor-mediated endocytosis by symbiont" EXACT [] is_a: GO:0044077 ! modulation by symbiont of host receptor-mediated endocytosis is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis [Term] id: GO:0044079 name: modulation by symbiont of host neurotransmitter secretion namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell or group of cells in its host organism." [MITRE:tk] subset: gosubset_prok synonym: "modification by symbiont of host neurotransmitter secretion" EXACT [] synonym: "modulation of host neurotransmitter secretion by symbiont" EXACT [] synonym: "regulation by symbiont of host neurotransmitter secretion" EXACT [] is_a: GO:0044063 ! modulation by symbiont of host neurological system process is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0046928 ! regulation of neurotransmitter secretion [Term] id: GO:0044080 name: modulation by symbiont of host cGMP-mediated signal transduction namespace: biological_process def: "Any process in which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [MITRE:tk] subset: gosubset_prok synonym: "modulation by symbiont of host cGMP-mediated signal transduction pathway" EXACT [] synonym: "modulation by symbiont of host cGMP-mediated signaling" EXACT [] synonym: "modulation by symbiont of host cGMP-mediated signalling" EXACT [] synonym: "modulation of host cGMP-mediated signal transduction by symbiont" EXACT [] synonym: "regulation by symbiont of host cGMP-mediated signal transduction" EXACT [] is_a: GO:0010752 ! regulation of cGMP-mediated signaling is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0044081 name: modulation by symbiont of host nitric oxide-mediated signal transduction namespace: biological_process def: "Any process in which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [MITRE:tk] subset: gosubset_prok synonym: "modulation by symbiont of host nitric oxide mediated signal transduction" EXACT [] synonym: "modulation of host nitric oxide-mediated signal transduction by symbiont" EXACT [] synonym: "modulation of host nitric oxide-mediated signaling by symbiont" EXACT [] synonym: "modulation of host nitric oxide-mediated signalling by symbiont" EXACT [] synonym: "regulation by symbiont of host nitric oxide-mediated signal transduction" EXACT [] is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0044082 name: modulation by symbiont of host small GTPase mediated signal transduction namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism." [MITRE:tk] subset: gosubset_prok synonym: "modulation of host small GTPase mediated signal transduction by symbiont" EXACT [] synonym: "regulation by symbiont of host small GTPase mediated signal transduction" EXACT [] is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0044083 name: modulation by symbiont of host Rho protein signal transduction namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of Rho protein signal transduction in its host organism." [MITRE:tk] subset: gosubset_prok synonym: "modulation by symbiont of host Rho protein mediated signal transduction" EXACT [] synonym: "modulation by symbiont of host Rho protein-mediated signal transduction" EXACT [] synonym: "modulation of host Rho protein signal transduction by symbiont" EXACT [] synonym: "modulation of host Rho protein signaling by symbiont" EXACT [] synonym: "modulation of host Rho protein signalling by symbiont" EXACT [] synonym: "regulation by symbiont of host Rho protein signal transduction" EXACT [] is_a: GO:0035023 ! regulation of Rho protein signal transduction is_a: GO:0044082 ! modulation by symbiont of host small GTPase mediated signal transduction [Term] id: GO:0044084 name: host cell membrane pore complex namespace: cellular_component def: "Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins." [MITRE:tk] subset: gosubset_prok synonym: "pore complex in host cell membrane" EXACT [] is_a: GO:0033644 ! host cell membrane [Term] id: GO:0044085 name: cellular component biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] subset: gosubset_prok is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0044087 name: regulation of cellular component biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044088 name: regulation of vacuole organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0007033 ! vacuole organization [Term] id: GO:0044089 name: positive regulation of cellular component biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044090 name: positive regulation of vacuole organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044088 ! regulation of vacuole organization relationship: positively_regulates GO:0007033 ! vacuole organization [Term] id: GO:0044091 name: membrane biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] is_a: GO:0071843 ! cellular component biogenesis at cellular level [Term] id: GO:0044092 name: negative regulation of molecular function namespace: biological_process def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0044093 name: positive regulation of molecular function namespace: biological_process def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0044094 name: host cell nuclear part namespace: cellular_component def: "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd] subset: gosubset_prok is_a: GO:0033646 ! host intracellular part relationship: part_of GO:0042025 ! host cell nucleus [Term] id: GO:0044095 name: host cell nucleoplasm namespace: cellular_component def: "That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd] subset: gosubset_prok is_a: GO:0044094 ! host cell nuclear part [Term] id: GO:0044096 name: type IV pilus namespace: cellular_component def: "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers." [GOC:pamgo_curators] subset: gosubset_prok synonym: "TFP" EXACT [] synonym: "type 4 pilus" EXACT [] synonym: "type IV fimbriae" EXACT [] is_a: GO:0009289 ! pilus [Term] id: GO:0044097 name: secretion by the type IV secretion system namespace: biological_process def: "The controlled release of proteins or DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators] synonym: "secretion via the type IV secretion system" EXACT [] is_a: GO:0032940 ! secretion by cell [Term] id: GO:0044098 name: DNA secretion by the type IV secretion system namespace: biological_process def: "The controlled release of DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators] synonym: "DNA secretion via the type IV secretion system" EXACT [] is_a: GO:0044097 ! secretion by the type IV secretion system [Term] id: GO:0044099 name: polar tube namespace: cellular_component def: "A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell." [GOC:mf, PMID:12076771, PMID:9723921] is_a: GO:0044464 ! cell part [Term] id: GO:0044100 name: sporoplasm namespace: cellular_component def: "The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms." [GOC:mf, PMID:12076771, PMID:16004371, PMID:9723921] is_a: GO:0044424 ! intracellular part [Term] id: GO:0044101 name: (R)-citramalyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA." [GOC:jl, IMG:03307] subset: gosubset_prok synonym: "Ccl" RELATED [] synonym: "R-citramalyl-CoA lyase activity" EXACT [] xref: EC:4.1.3.- xref: IMG:03307 xref: MetaCyc:CPLX-7553 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0044102 name: purine deoxyribosyltransferase activity namespace: molecular_function def: "Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor." [GOC:jl, IMG:03313, PMID:11836245] subset: gosubset_prok synonym: "PTD" RELATED [] synonym: "purine 2'-deoxyribosyltransferase activity" EXACT [] xref: EC:2.4.2.- xref: IMG:03313 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0044103 name: L-arabinose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+." [GOC:jl, IMG:03333] subset: gosubset_prok xref: EC:1.1.1.- xref: IMG:03333 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0044104 name: 2,5-dioxovalerate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+." [IMG:03338, PMID:16835232, PMID:17202142] subset: gosubset_prok synonym: "2,5-dioxopentanoate dehydrogenase (NAD+) activity" EXACT [] synonym: "2,5-dioxopentanoate:NAD+ 5-oxidoreductase activity" EXACT [] xref: EC:1.2.1.- xref: IMG:03338 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0044105 name: L-xylulose reductase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+." [IMG:03341, PMID:14736891] subset: gosubset_prok xref: EC:1.1.1.- xref: IMG:03341 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0044106 name: cellular amine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl] is_a: GO:0009308 ! amine metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0044107 name: cellular alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells." [GOC:jl] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044108 name: cellular alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell." [GOC:jl] is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0044109 name: cellular alcohol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell." [GOC:jl] is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0044110 name: growth involved in symbiotic interaction namespace: biological_process def: "The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'development during symbiotic interaction ; GO:0044111'. subset: gosubset_prok synonym: "growth during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0040007 ! growth relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0044111 name: development involved in symbiotic interaction namespace: biological_process def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'growth during symbiotic interaction ; GO:0044110'. subset: gosubset_prok synonym: "development during symbiotic interaction" RELATED [gOC:dph] is_a: GO:0032502 ! developmental process relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0044112 name: growth in other organism involved in symbiotic interaction namespace: biological_process def: "The increase in size or mass of an organism, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc, GOC:jl] comment: This term partially replaces the obsolete term 'growth or development in other organism during symbiotic interaction ; GO:0051831'. See also 'development in other organism during symbiotic interaction ; GO:0044113'. synonym: "growth in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0044110 ! growth involved in symbiotic interaction [Term] id: GO:0044113 name: development in other organism involved in symbiotic interaction namespace: biological_process def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GO:jl, GOC:cc] comment: This term partially replaces the obsolete term 'growth or development in other organism during symbiotic interaction ; GO:0051831'. See also 'growth in other organism during symbiotic interaction ; GO:0044112'. subset: gosubset_prok synonym: "development in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044111 ! development involved in symbiotic interaction [Term] id: GO:0044114 name: development of symbiont in host namespace: biological_process def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'growth of symbiont in host ; GO:0044117'. subset: gosubset_prok is_a: GO:0044115 ! development of symbiont involved in interaction with host [Term] id: GO:0044115 name: development of symbiont involved in interaction with host namespace: biological_process def: "The progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont during interaction with host ; GO:0052108'. See also 'growth of symbiont during interaction with host ; GO:0044116'. subset: gosubset_prok synonym: "development of symbiont during interaction with host" RELATED [GOC:dph] is_a: GO:0044111 ! development involved in symbiotic interaction [Term] id: GO:0044116 name: growth of symbiont involved in interaction with host namespace: biological_process def: "The increase in size or mass of an organism, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont during interaction with host ; GO:0052108'. See also 'development of symbiont during interaction with host ; GO:0044115'. subset: gosubset_prok synonym: "growth of symbiont during interaction with host" RELATED [GOC:tb] is_a: GO:0044110 ! growth involved in symbiotic interaction [Term] id: GO:0044117 name: growth of symbiont in host namespace: biological_process def: "The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'development of symbiont in host ; GO:0044114'. subset: gosubset_prok is_a: GO:0044116 ! growth of symbiont involved in interaction with host [Term] id: GO:0044118 name: development of symbiont in host cell namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host cell ; GO:0075065'. See also 'growth of symbiont in host cell ; GO:0044119'. subset: gosubset_prok is_a: GO:0044114 ! development of symbiont in host [Term] id: GO:0044119 name: growth of symbiont in host cell namespace: biological_process def: "The increase in size or mass of symbiont, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host cell ; GO:0075065'. See also 'development of symbiont in host cell ; GO:0044118'. subset: gosubset_prok is_a: GO:0044117 ! growth of symbiont in host [Term] id: GO:0044120 name: development of symbiont in host organelle namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'growth of symbiont in host organelle ; GO:0044121'. subset: gosubset_prok is_a: GO:0044118 ! development of symbiont in host cell [Term] id: GO:0044121 name: growth of symbiont in host organelle namespace: biological_process def: "The increase in size or mass of a symbiont, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'development of symbiont in host organelle ; GO:0044120'. subset: gosubset_prok is_a: GO:0044119 ! growth of symbiont in host cell [Term] id: GO:0044122 name: development of symbiont in host vascular tissue namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'growth of symbiont in host vascular tissue ; GO:0044123'. subset: gosubset_prok is_a: GO:0044114 ! development of symbiont in host [Term] id: GO:0044123 name: growth of symbiont in host vascular tissue namespace: biological_process def: "The increase in size or mass of symbiont, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'development of symbiont in host vascular tissue ; GO:0044122'. subset: gosubset_prok is_a: GO:0044117 ! growth of symbiont in host [Term] id: GO:0044124 name: development of symbiont in host intercellular space namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host intercellular space ; GO:0075067'. See also 'growth of symbiont in host intercellular space ; GO:0044125'. subset: gosubset_prok is_a: GO:0044114 ! development of symbiont in host [Term] id: GO:0044125 name: growth of symbiont in host intercellular space namespace: biological_process def: "The increase in size or mass of symbiont, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host intercellular space ; GO:0075067'. See also 'development of symbiont in host intercellular space ; GO:0044124'. subset: gosubset_prok is_a: GO:0044117 ! growth of symbiont in host [Term] id: GO:0044126 name: regulation of growth of symbiont in host namespace: biological_process def: "Any process in which the symbiont regulates the increase in its size or mass within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of development of symbiont in host ; GO:0044127'. subset: gosubset_prok is_a: GO:0040008 ! regulation of growth is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism relationship: regulates GO:0044117 ! growth of symbiont in host [Term] id: GO:0044127 name: regulation of development of symbiont in host namespace: biological_process def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of growth of symbiont in host ; GO:0044126'. subset: gosubset_prok is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0044114 ! development of symbiont in host [Term] id: GO:0044128 name: positive regulation of growth of symbiont in host namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont in host ; GO:0033666'. See also 'positive regulation of development of symbiont in host ; GO:0044129'. subset: gosubset_prok is_a: GO:0044126 ! regulation of growth of symbiont in host is_a: GO:0044148 ! positive regulation of growth of symbiont involved in interaction with host relationship: positively_regulates GO:0044117 ! growth of symbiont in host [Term] id: GO:0044129 name: positive regulation of development of symbiont in host namespace: biological_process def: "Any process in which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont in host ; GO:0033666'. See also 'positive regulation of growth of symbiont in host ; GO:0044128'. subset: gosubset_prok is_a: GO:0044127 ! regulation of development of symbiont in host is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host relationship: positively_regulates GO:0044114 ! development of symbiont in host [Term] id: GO:0044130 name: negative regulation of growth of symbiont in host namespace: biological_process def: "Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont in host ; GO:0033667'. See also 'negative regulation of development of symbiont in host ; GO:0044131'. subset: gosubset_prok is_a: GO:0044126 ! regulation of growth of symbiont in host is_a: GO:0044146 ! negative regulation of growth of symbiont involved in interaction with host relationship: negatively_regulates GO:0044117 ! growth of symbiont in host [Term] id: GO:0044131 name: negative regulation of development of symbiont in host namespace: biological_process def: "Any process in which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont in host ; GO:0033667'. See also 'negative regulation of growth of symbiont in host ; GO:0044130'. subset: gosubset_prok is_a: GO:0044127 ! regulation of development of symbiont in host is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host relationship: negatively_regulates GO:0044114 ! development of symbiont in host [Term] id: GO:0044132 name: development of symbiont on or near host namespace: biological_process def: "The progression of a symbiont from an initial condition to a later condition, within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'growth of symbiont on or near host ; GO:0044133'. subset: gosubset_prok is_a: GO:0044115 ! development of symbiont involved in interaction with host [Term] id: GO:0044133 name: growth of symbiont on or near host namespace: biological_process def: "The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'development of symbiont on or near host ; GO:0044132'. subset: gosubset_prok is_a: GO:0044116 ! growth of symbiont involved in interaction with host [Term] id: GO:0044134 name: development of symbiont on or near host phyllosphere namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host phyllosphere ; GO:0075013'. See also 'growth of symbiont on or near host phyllosphere ; GO:0044135'. is_a: GO:0044132 ! development of symbiont on or near host [Term] id: GO:0044135 name: growth of symbiont on or near host phyllosphere namespace: biological_process def: "The increase in size or mass of symbiont occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host phyllosphere ; GO:0075013'. See also 'development of symbiont on or near host phyllosphere ; GO:0044134'. is_a: GO:0044133 ! growth of symbiont on or near host [Term] id: GO:0044136 name: development of symbiont on or near host rhizosphere namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host rhizosphere ; GO:0075014'. See also 'growth of symbiont on or near host rhizosphere ; GO:0044137'. subset: gosubset_prok is_a: GO:0044132 ! development of symbiont on or near host [Term] id: GO:0044137 name: growth of symbiont on or near host rhizosphere namespace: biological_process def: "The increase in size or mass of symbiont occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host rhizosphere ; GO:0075014'. See also 'development of symbiont on or near host rhizosphere ; GO:0044136'. subset: gosubset_prok is_a: GO:0044133 ! growth of symbiont on or near host [Term] id: GO:0044138 name: modulation of development of symbiont on or near host namespace: biological_process def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont on or near host ; GO:0075305'. See also 'modulation of growth of symbiont on or near host ; GO:0044139'. subset: gosubset_prok is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host relationship: regulates GO:0044132 ! development of symbiont on or near host [Term] id: GO:0044139 name: modulation of growth of symbiont on or near host namespace: biological_process def: "Any process in which the symbiont regulates the increase in its size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont on or near host ; GO:0075305'. See also 'modulation of development of symbiont on or near host ; GO:0044138'. subset: gosubset_prok is_a: GO:0044144 ! modulation of growth of symbiont involved in interaction with host relationship: regulates GO:0044133 ! growth of symbiont on or near host [Term] id: GO:0044140 name: negative regulation of growth of symbiont on or near host surface namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont on or near host surface ; GO:0075309'. See also 'negative regulation of development of symbiont on or near host surface ; GO:0044141'. subset: gosubset_prok is_a: GO:0044139 ! modulation of growth of symbiont on or near host is_a: GO:0044146 ! negative regulation of growth of symbiont involved in interaction with host relationship: negatively_regulates GO:0044133 ! growth of symbiont on or near host [Term] id: GO:0044141 name: negative regulation of development of symbiont on or near host surface namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont on or near host surface ; GO:0075309'. See also 'negative regulation of growth of symbiont on or near host surface ; GO:0044140'. subset: gosubset_prok is_a: GO:0044138 ! modulation of development of symbiont on or near host is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host relationship: negatively_regulates GO:0044132 ! development of symbiont on or near host [Term] id: GO:0044142 name: positive regulation of growth of symbiont on or near host surface namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont on or near host surface ; GO:0075337'. See also 'positive regulation of development of symbiont on or near host surface ; GO:0044143'. subset: gosubset_prok is_a: GO:0044139 ! modulation of growth of symbiont on or near host is_a: GO:0044148 ! positive regulation of growth of symbiont involved in interaction with host relationship: positively_regulates GO:0044133 ! growth of symbiont on or near host [Term] id: GO:0044143 name: positive regulation of development of symbiont on or near host surface namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont on or near host surface ; GO:0075337'. See also 'positive regulation of growth of symbiont on or near host surface ; GO:0044142'. subset: gosubset_prok is_a: GO:0044138 ! modulation of development of symbiont on or near host is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host relationship: positively_regulates GO:0044132 ! development of symbiont on or near host [Term] id: GO:0044144 name: modulation of growth of symbiont involved in interaction with host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of development of symbiont during interaction with host ; GO:0044145'. subset: gosubset_prok synonym: "modulation of growth of symbiont during interaction with host" RELATED [GOC:tb] is_a: GO:0040008 ! regulation of growth is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism relationship: regulates GO:0044116 ! growth of symbiont involved in interaction with host [Term] id: GO:0044145 name: modulation of development of symbiont involved in interaction with host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'. subset: gosubset_prok synonym: "modulation of development of symbiont during interaction with host" RELATED [GOC:dph] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0044115 ! development of symbiont involved in interaction with host [Term] id: GO:0044146 name: negative regulation of growth of symbiont involved in interaction with host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'. See also 'negative regulation of development of symbiont during interaction with host ; GO:0044147'. subset: gosubset_prok synonym: "negative regulation of growth of symbiont during interaction with host" RELATED [GOC:tb] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0044144 ! modulation of growth of symbiont involved in interaction with host is_a: GO:0045926 ! negative regulation of growth relationship: negatively_regulates GO:0044116 ! growth of symbiont involved in interaction with host [Term] id: GO:0044147 name: negative regulation of development of symbiont involved in interaction with host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'. See also 'negative regulation of growth of symbiont during interaction with host ; GO:0044146'. synonym: "negative regulation of development of symbiont during interaction with host" RELATED [GOC:dph] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0044115 ! development of symbiont involved in interaction with host [Term] id: GO:0044148 name: positive regulation of growth of symbiont involved in interaction with host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of development of symbiont during interaction with host ; GO:0044149'. subset: gosubset_prok synonym: "positive regulation of growth of symbiont during interaction with host" RELATED [GOC:tb] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0044144 ! modulation of growth of symbiont involved in interaction with host is_a: GO:0045927 ! positive regulation of growth relationship: positively_regulates GO:0044116 ! growth of symbiont involved in interaction with host [Term] id: GO:0044149 name: positive regulation of development of symbiont involved in interaction with host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'. subset: gosubset_prok synonym: "positive regulation of development of symbiont during interaction with host" RELATED [GOC:dph] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0044115 ! development of symbiont involved in interaction with host [Term] id: GO:0044150 name: development of organism on or near symbiont surface namespace: biological_process def: "The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl] subset: gosubset_prok is_a: GO:0044152 ! development on or near surface of other organism involved in symbiotic interaction [Term] id: GO:0044151 name: growth of organism on or near symbiont surface namespace: biological_process def: "The increase in size or mass of an organism occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl] comment: This term partially replaces the obsolete term 'growth or development of organism on or near symbiont surface ; GO:0051857'. See also 'development of organism on or near symbiont surface ; GO:0044150'. subset: gosubset_prok is_a: GO:0044153 ! growth on or near surface of other organism involved in symbiotic interaction [Term] id: GO:0044152 name: development on or near surface of other organism involved in symbiotic interaction namespace: biological_process def: "The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc, GOC:jl] comment: This term partially replaces the obsolete term 'growth or development on or near surface of other organism during symbiotic interaction ; GO:0051827'. See also 'growth on or near surface of other organism during symbiotic interaction ; GO:0044153'. subset: gosubset_prok synonym: "development on or near surface of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044111 ! development involved in symbiotic interaction [Term] id: GO:0044153 name: growth on or near surface of other organism involved in symbiotic interaction namespace: biological_process def: "The increase in size or mass of an organism occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc, GOC:jl] comment: This term partially replaces the obsolete term 'growth or development on or near surface of other organism during symbiotic interaction ; GO:0051827'. See also 'development on or near surface of other organism during symbiotic interaction ; GO:0044152'. subset: gosubset_prok synonym: "growth on or near surface of other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0044110 ! growth involved in symbiotic interaction [Term] id: GO:0044154 name: histone H3-K14 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone." [GOC:jl, GOC:lb, PMID:17194708] synonym: "histone H3 acetylation at K14" EXACT [] synonym: "histone H3K14 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0044155 name: host caveola namespace: cellular_component def: "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:rph] is_a: GO:0033643 ! host cell part relationship: part_of GO:0033644 ! host cell membrane [Term] id: GO:0044156 name: host cell junction namespace: cellular_component def: "A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:rph] is_a: GO:0033643 ! host cell part relationship: part_of GO:0020002 ! host cell plasma membrane [Term] id: GO:0044157 name: host cell projection namespace: cellular_component def: "A prolongation or process extending from a host cell, e.g. a flagellum or axon." [GOC:rph] subset: gosubset_prok is_a: GO:0033643 ! host cell part [Term] id: GO:0044158 name: host cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [GOC:rph] is_a: GO:0033643 ! host cell part [Term] id: GO:0044159 name: host thylakoid namespace: cellular_component def: "A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:rph] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044160 name: host thylakoid membrane namespace: cellular_component def: "The pigmented membrane of any host thylakoid." [GOC:rph] is_a: GO:0033644 ! host cell membrane is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044159 ! host thylakoid [Term] id: GO:0044161 name: host cell cytoplasmic vesicle namespace: cellular_component def: "A vesicle formed of membrane or protein, found in the cytoplasm of a host cell." [GOC:rph] is_a: GO:0033647 ! host intracellular organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044162 name: host cell cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a host cell cytoplasmic vesicle." [GOC:rph] is_a: GO:0033644 ! host cell membrane is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044161 ! host cell cytoplasmic vesicle [Term] id: GO:0044163 name: host cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph] is_a: GO:0033646 ! host intracellular part [Term] id: GO:0044164 name: host cell cytosol namespace: cellular_component def: "The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:jl] subset: gosubset_prok synonym: "host cytosol" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044165 name: host cell endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GOC:jl] subset: gosubset_prok synonym: "host endoplasmic reticulum" EXACT [] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044166 name: host cell endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the host cell endoplasmic reticulum." [GOC:jl] subset: gosubset_prok synonym: "host endoplasmic reticulum lumen" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044165 ! host cell endoplasmic reticulum [Term] id: GO:0044167 name: host cell endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the host cell endoplasmic reticulum." [GOC:jl] subset: gosubset_prok synonym: "host endoplasmic reticulum membrane" EXACT [] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0033645 ! host cell endomembrane system relationship: part_of GO:0044165 ! host cell endoplasmic reticulum [Term] id: GO:0044168 name: host cell rough endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface." [GOC:jl] subset: gosubset_prok synonym: "host rough endoplasmic reticulum" EXACT [] is_a: GO:0044165 ! host cell endoplasmic reticulum [Term] id: GO:0044169 name: host cell rough endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the host cell rough endoplasmic reticulum." [GOC:jl] subset: gosubset_prok synonym: "host rough endoplasmic reticulum membrane" EXACT [] is_a: GO:0044167 ! host cell endoplasmic reticulum membrane relationship: part_of GO:0044168 ! host cell rough endoplasmic reticulum [Term] id: GO:0044170 name: host cell smooth endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface." [GOC:jl] subset: gosubset_prok synonym: "host smooth endoplasmic reticulum" EXACT [] is_a: GO:0044165 ! host cell endoplasmic reticulum [Term] id: GO:0044171 name: host cell smooth endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the host cell smooth endoplasmic reticulum." [GOC:jl] subset: gosubset_prok synonym: "host smooth endoplasmic reticulum membrane" EXACT [] is_a: GO:0044167 ! host cell endoplasmic reticulum membrane relationship: part_of GO:0044170 ! host cell smooth endoplasmic reticulum [Term] id: GO:0044172 name: host cell endoplasmic reticulum-Golgi intermediate compartment namespace: cellular_component def: "A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [GOC:jl] subset: gosubset_prok synonym: "host cell ER-Golgi intermediate compartment" EXACT [] synonym: "host ER-Golgi intermediate compartment" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044173 name: host cell endoplasmic reticulum-Golgi intermediate compartment membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system." [GOC:jl] subset: gosubset_prok synonym: "host cell ER-Golgi intermediate compartment membrane" EXACT [] synonym: "host endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT [] synonym: "host ER-Golgi intermediate compartment membrane" EXACT [] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044172 ! host cell endoplasmic reticulum-Golgi intermediate compartment [Term] id: GO:0044174 name: host cell endosome namespace: cellular_component def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation." [GOC:jl] subset: gosubset_prok synonym: "host endosome" EXACT [] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044175 name: host cell endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a host cell endosome." [GOC:jl] synonym: "host endosome membrane" EXACT [] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044174 ! host cell endosome [Term] id: GO:0044176 name: host cell filopodium namespace: cellular_component def: "Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:jl] subset: gosubset_prok synonym: "host filopodium" EXACT [] is_a: GO:0044157 ! host cell projection [Term] id: GO:0044177 name: host cell Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] subset: gosubset_prok synonym: "host Golgi apparatus" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044178 name: host cell Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus." [GOC:jl] subset: gosubset_prok synonym: "host Golgi membrane" EXACT [] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0033645 ! host cell endomembrane system relationship: part_of GO:0044177 ! host cell Golgi apparatus [Term] id: GO:0044179 name: hemolysis in other organism namespace: biological_process def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another." [GOC:jl] subset: gosubset_prok synonym: "hemolysis of cells in other organism" EXACT [GOC:bf] synonym: "hemolysis of erythrocytes in other organism" EXACT [] synonym: "hemolysis of RBCs in other organism" EXACT [] synonym: "hemolysis of red blood cells in other organism" EXACT [] is_a: GO:0051715 ! cytolysis in other organism [Term] id: GO:0044180 name: filamentous growth of a unicellular organism namespace: biological_process def: "The process in which a unicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] is_a: GO:0030447 ! filamentous growth [Term] id: GO:0044181 name: filamentous growth of a multicellular organism namespace: biological_process def: "The process in which a multicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] is_a: GO:0030447 ! filamentous growth is_a: GO:0060560 ! developmental growth involved in morphogenesis [Term] id: GO:0044182 name: filamentous growth of a population of unicellular organisms namespace: biological_process def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] is_a: GO:0030447 ! filamentous growth [Term] id: GO:0044183 name: protein binding involved in protein folding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding." [GOC:mtg_cambridge_2009] synonym: "chaperone activity" BROAD [] is_a: GO:0005515 ! protein binding [Term] id: GO:0044184 name: host cell late endosome namespace: cellular_component def: "A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [GOC:jl] subset: gosubset_prok is_a: GO:0044174 ! host cell endosome [Term] id: GO:0044185 name: host cell late endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a host cell late endosome." [GOC:jl] subset: gosubset_prok is_a: GO:0044175 ! host cell endosome membrane relationship: part_of GO:0044184 ! host cell late endosome [Term] id: GO:0044186 name: host cell lipid particle namespace: cellular_component def: "Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins." [GOC:jl] subset: gosubset_prok is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044187 name: host cell lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions." [GOC:jl] subset: gosubset_prok is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044188 name: host cell lysosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm." [GOC:jl] subset: gosubset_prok is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044187 ! host cell lysosome [Term] id: GO:0044189 name: host cell microsome namespace: cellular_component def: "Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g." [GOC:jl] subset: gosubset_prok synonym: "host cell microsomal membrane " EXACT [] is_a: GO:0033643 ! host cell part [Term] id: GO:0044190 name: host cell mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space." [GOC:jl] subset: gosubset_prok is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0033650 ! host cell mitochondrion [Term] id: GO:0044191 name: host cell mitochondrial membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope." [GOC:jl] subset: gosubset_prok is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044190 ! host cell mitochondrial envelope [Term] id: GO:0044192 name: host cell mitochondrial inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae." [GOC:jl] subset: gosubset_prok is_a: GO:0044191 ! host cell mitochondrial membrane [Term] id: GO:0044193 name: host cell mitochondrial outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope." [GOC:jl] subset: gosubset_prok is_a: GO:0044191 ! host cell mitochondrial membrane [Term] id: GO:0044194 name: cytolytic granule namespace: cellular_component def: "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells." [GOC:jl, PMID:11052265, PMID:12766758] is_a: GO:0005764 ! lysosome [Term] id: GO:0044195 name: nucleoplasmic reticulum namespace: cellular_component def: "Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport." [GOC:jl, PMID:17959832, PMID:9024685] synonym: "nuclear channels" EXACT [] is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0044196 name: host cell nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic host cells." [GOC:jl] subset: gosubset_prok is_a: GO:0044094 ! host cell nuclear part [Term] id: GO:0044197 name: Rel homology domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT." [http://en.wikipedia.org/wiki/Rel_homology_domain, InterPro:IPR011539] synonym: "RHD binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0044198 name: zf-TRAF domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a TRAF-type zinc finger domain of a protein." [InterPro:IPR001293] synonym: "TRAF-type zinc finger domain binding" EXACT [] synonym: "zinc finger TRAF-type domain binding" EXACT [] synonym: "zinc-finger-TRAF domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0044199 name: host cell nuclear envelope namespace: cellular_component def: "The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [GOC:jl] subset: gosubset_prok is_a: GO:0044094 ! host cell nuclear part relationship: part_of GO:0033645 ! host cell endomembrane system [Term] id: GO:0044200 name: host cell nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:jl] subset: gosubset_prok is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044199 ! host cell nuclear envelope [Term] id: GO:0044201 name: host cell nuclear inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope." [GOC:jl] subset: gosubset_prok is_a: GO:0044200 ! host cell nuclear membrane [Term] id: GO:0044202 name: host cell nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes." [GOC:jl] subset: gosubset_prok is_a: GO:0044200 ! host cell nuclear membrane [Term] id: GO:0044203 name: host cell nuclear lamina namespace: cellular_component def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments." [GOC:jl] subset: gosubset_prok is_a: GO:0044094 ! host cell nuclear part relationship: part_of GO:0044201 ! host cell nuclear inner membrane [Term] id: GO:0044204 name: host cell nuclear matrix namespace: cellular_component def: "The dense fibrillar network lying on the inner side of the host nuclear membrane." [GOC:jl] subset: gosubset_prok is_a: GO:0044094 ! host cell nuclear part [Term] id: GO:0044205 name: 'de novo' UMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl] synonym: "'de novo' UMP biosynthesis" EXACT [] is_a: GO:0006222 ! UMP biosynthetic process [Term] id: GO:0044206 name: UMP salvage namespace: biological_process def: "Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496] synonym: "UMP biosynthesis via nucleoside salvage pathway" EXACT [] synonym: "UMP biosynthetic process via nucleoside salvage pathway" EXACT [] is_a: GO:0006222 ! UMP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage [Term] id: GO:0044207 name: translation initiation ternary complex namespace: cellular_component def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl] synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW [] synonym: "translation initiation (ternary) complex" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0044208 name: 'de novo' AMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP)." [GOC:ecd, PMID:10888601] is_a: GO:0006167 ! AMP biosynthetic process [Term] id: GO:0044209 name: AMP salvage namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis." [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350] synonym: "adenosine monophosphate salvage" EXACT [] synonym: "AMP biosynthetic process via salvage pathway" EXACT [] is_a: GO:0006167 ! AMP biosynthetic process is_a: GO:0032261 ! purine nucleotide salvage [Term] id: GO:0044210 name: 'de novo' CTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components." [GOC:ecd, GOC:jl, PMID:11912132, PMID:18439916] synonym: "'de novo' cytidine 5'-triphosphate biosynthetic process" EXACT [] is_a: GO:0006241 ! CTP biosynthetic process [Term] id: GO:0044211 name: CTP salvage namespace: biological_process def: "Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis." [GOC:ecd, GOC:jl, PMID:10501935] synonym: "CTP biosynthetic process via salvage pathway" EXACT [] synonym: "cytidine 5'-triphosphate salvage" EXACT [] is_a: GO:0006241 ! CTP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage [Term] id: GO:0044212 name: transcription regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000975 ! regulatory region DNA binding [Term] id: GO:0044213 name: intronic transcription regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within." [GOC:ecd, GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0044214 name: fully spanning the plasma membrane namespace: cellular_component def: "Fully spanning both phospholipid bilayers of a plasma membrane." [GOC:ecd] synonym: "transmembrane" RELATED [GOC:mah] is_a: GO:0044425 ! membrane part [Term] id: GO:0044215 name: other organism namespace: cellular_component def: "A secondary organism with which the first organism is interacting." [GOC:jl] is_a: GO:0043245 ! extraorganismal space [Term] id: GO:0044216 name: other organism cell namespace: cellular_component def: "A cell of a secondary organism with which the first organism is interacting." [GOC:jl] is_a: GO:0044217 ! other organism part [Term] id: GO:0044217 name: other organism part namespace: cellular_component def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl] is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0044215 ! other organism [Term] id: GO:0044218 name: other organism cell membrane namespace: cellular_component def: "The cell membrane of a secondary organism with which the first organism is interacting." [GOC:jl] synonym: "foreign membrane" RELATED [] is_a: GO:0044279 ! other organism membrane relationship: part_of GO:0044216 ! other organism cell [Term] id: GO:0044219 name: host cell plasmodesma namespace: cellular_component def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell." [GOC:rph] is_a: GO:0044156 ! host cell junction [Term] id: GO:0044220 name: host cell perinuclear region of cytoplasm namespace: cellular_component def: "The host cell cytoplasm situated near, or occurring around, the host nucleus." [GOC:rph] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0044221 name: host cell synapse namespace: cellular_component def: "The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication." [GOC:rph] is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0018995 ! host [Term] id: GO:0044222 name: anammoxosome namespace: cellular_component def: "An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism." [GOC:dh, PMID:17993524, PMID:19682260] subset: gosubset_prok is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0044223 name: pirellulosome namespace: cellular_component def: "A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm." [GOC:dh, PMID:19133117] subset: gosubset_prok is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0044224 name: juxtaparanode region of axon namespace: cellular_component def: "A region of an axon near a node of Ranvier that is between the paranode and internode regions." [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359] synonym: "juxtaparanodal region" EXACT [] synonym: "juxtaparanode" EXACT [] xref: NIF_Subcellular:sao758620702 is_a: GO:0033267 ! axon part relationship: part_of GO:0044304 ! main axon [Term] id: GO:0044225 name: apical pole of neuron namespace: cellular_component def: "Portion of a neuron cell soma closest to the point where the apical dendrite emerges." [NIF_Subcellular:sao1186862860] xref: NIF_Subcellular:sao1186862860 is_a: GO:0060187 ! cell pole relationship: part_of GO:0043025 ! neuronal cell body [Term] id: GO:0044226 name: basal pole of neuron namespace: cellular_component def: "Portion of a neuron cell soma closest to the point where the basilar dendrite emerges." [NIF_Subcellular:sao1186862860] xref: NIF_Subcellular:sao1186862860 is_a: GO:0060187 ! cell pole relationship: part_of GO:0043025 ! neuronal cell body [Term] id: GO:0044227 name: methane-oxidizing organelle namespace: cellular_component def: "A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms." [GOC:dh] subset: gosubset_prok synonym: "methane-oxidizing compartment" EXACT [] synonym: "methanotroph intracytoplasmic membrane-bound compartment" EXACT [] is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0044228 name: host cell surface namespace: cellular_component def: "The external part of the host cell wall and/or host plasma membrane." [GOC:rph] subset: gosubset_prok is_a: GO:0033643 ! host cell part [Term] id: GO:0044229 name: host cell periplasmic space namespace: cellular_component def: "The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi)." [GOC:rph] subset: gosubset_prok is_a: GO:0033643 ! host cell part [Term] id: GO:0044230 name: host cell envelope namespace: cellular_component def: "An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present." [GOC:rph] is_a: GO:0033643 ! host cell part [Term] id: GO:0044231 name: host cell presynaptic membrane namespace: cellular_component def: "A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:rph] subset: gosubset_prok is_a: GO:0033644 ! host cell membrane is_a: GO:0072556 ! other organism presynaptic membrane relationship: part_of GO:0044221 ! host cell synapse [Term] id: GO:0044232 name: organelle membrane contact site namespace: cellular_component def: "A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions." [GOC:jl, PMID:16806880] synonym: "inter-organelle junction" EXACT [] synonym: "interorganelle junction" EXACT [] synonym: "MCS" EXACT [] is_a: GO:0044422 ! organelle part is_a: GO:0044425 ! membrane part relationship: part_of GO:0031090 ! organelle membrane [Term] id: GO:0044233 name: ER-mitochondrion membrane contact site namespace: cellular_component def: "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461] synonym: "endoplasmic-reticulum-mitochondrion membrane contact site" EXACT [] is_a: GO:0044232 ! organelle membrane contact site is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane relationship: part_of GO:0031966 ! mitochondrial membrane [Term] id: GO:0044234 name: cell wall organization in other organism namespace: biological_process def: "A process performed by an organism that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall of a second organism." [GOC:jl] subset: gosubset_prok is_a: GO:0044235 ! cellular component organization in other organism is_a: GO:0071555 ! cell wall organization [Term] id: GO:0044235 name: cellular component organization in other organism namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component in a second organism." [GOC:jl] is_a: GO:0016043 ! cellular component organization is_a: GO:0051704 ! multi-organism process [Term] id: GO:0044236 name: multicellular organismal metabolic process namespace: biological_process def: "The chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators] synonym: "multicellular organismal metabolism" EXACT [] is_a: GO:0008152 ! metabolic process is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0044237 name: cellular metabolic process namespace: biological_process def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "cellular metabolism" EXACT [] synonym: "intermediary metabolism" RELATED [GOC:mah] is_a: GO:0008152 ! metabolic process is_a: GO:0009987 ! cellular process [Term] id: GO:0044238 name: primary metabolic process namespace: biological_process def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org] subset: goslim_pir subset: gosubset_prok synonym: "primary metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0044239 name: salivary polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth." [GOC:jl, http://www.emc.maricopa.edu/] synonym: "salivary polysaccharide breakdown" EXACT [] synonym: "salivary polysaccharide catabolism" EXACT [] synonym: "salivary polysaccharide degradation" EXACT [] is_a: GO:0044244 ! multicellular organismal polysaccharide catabolic process [Term] id: GO:0044240 name: multicellular organismal lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipids, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl] synonym: "organismal lipid breakdown" EXACT [] synonym: "organismal lipid catabolism" EXACT [] synonym: "organismal lipid degradation" EXACT [] is_a: GO:0016042 ! lipid catabolic process is_a: GO:0044243 ! multicellular organismal catabolic process relationship: part_of GO:0044241 ! lipid digestion [Term] id: GO:0044241 name: lipid digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] xref: Reactome:1253469 "Digestion of dietary lipid" xref: Reactome:1280407 "Digestion of dietary lipid" xref: Reactome:1299243 "Digestion of dietary lipid" xref: Reactome:1326985 "Digestion of dietary lipid" xref: Reactome:1353080 "Digestion of dietary lipid" xref: Reactome:1373269 "Digestion of dietary lipid" xref: Reactome:1393289 "Digestion of dietary lipid" xref: Reactome:1417781 "Digestion of dietary lipid" xref: Reactome:1450881 "Digestion of dietary lipid" xref: Reactome:192456 "Digestion of dietary lipid" is_a: GO:0007586 ! digestion [Term] id: GO:0044242 name: cellular lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular lipid breakdown" EXACT [] synonym: "cellular lipid catabolism" EXACT [] synonym: "cellular lipid degradation" EXACT [] is_a: GO:0016042 ! lipid catabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0044243 name: multicellular organismal catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of substances in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators] synonym: "organismal breakdown" EXACT [] synonym: "organismal catabolism" EXACT [] synonym: "organismal degradation" EXACT [] is_a: GO:0044236 ! multicellular organismal metabolic process [Term] id: GO:0044244 name: multicellular organismal polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl] synonym: "organismal polysaccharide breakdown" EXACT [] synonym: "organismal polysaccharide catabolism" EXACT [] synonym: "organismal polysaccharide degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044263 ! multicellular organismal polysaccharide metabolic process is_a: GO:0044276 ! multicellular organismal carbohydrate catabolic process relationship: part_of GO:0044245 ! polysaccharide digestion [Term] id: GO:0044245 name: polysaccharide digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] xref: Reactome:1253424 "Digestion of dietary carbohydrate" xref: Reactome:1280364 "Digestion of dietary carbohydrate" xref: Reactome:1299203 "Digestion of dietary carbohydrate" xref: Reactome:1326942 "Digestion of dietary carbohydrate" xref: Reactome:1353037 "Digestion of dietary carbohydrate" xref: Reactome:1373228 "Digestion of dietary carbohydrate" xref: Reactome:1393246 "Digestion of dietary carbohydrate" xref: Reactome:1417738 "Digestion of dietary carbohydrate" xref: Reactome:1450838 "Digestion of dietary carbohydrate" xref: Reactome:1471242 "Digestion of dietary carbohydrate" xref: Reactome:1483232 "Digestion of dietary carbohydrate" xref: Reactome:1496920 "Digestion of dietary carbohydrate" xref: Reactome:1514308 "Digestion of dietary carbohydrate" xref: Reactome:1521176 "Digestion of dietary carbohydrate" xref: Reactome:1532655 "Digestion of dietary carbohydrate" xref: Reactome:189085 "Digestion of dietary carbohydrate" is_a: GO:0007586 ! digestion [Term] id: GO:0044246 name: regulation of multicellular organismal metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:go_curators, GOC:tb] synonym: "regulation of organismal metabolic process" EXACT [GOC:tb] synonym: "regulation of organismal metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0044236 ! multicellular organismal metabolic process [Term] id: GO:0044247 name: cellular polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular polysaccharide breakdown" EXACT [] synonym: "cellular polysaccharide catabolism" EXACT [] synonym: "cellular polysaccharide degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0044248 name: cellular catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular breakdown" EXACT [] synonym: "cellular catabolism" EXACT [] synonym: "cellular degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044249 name: cellular biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular anabolism" EXACT [] synonym: "cellular biosynthesis" EXACT [] synonym: "cellular formation" EXACT [] synonym: "cellular synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044250 name: negative regulation of metabolic activity involved in hibernation namespace: biological_process def: "The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation." [GOC:jl, Wikipedia:Hibernation] synonym: "down regulation of metabolic activity during hibernation" RELATED [] synonym: "down-regulation of metabolic activity during hibernation" RELATED [] synonym: "downregulation of metabolic activity during hibernation" RELATED [] synonym: "inhibition of metabolic activity during hibernation" NARROW [] synonym: "negative regulation of metabolic activity during hibernation" RELATED [GOC:tb] is_a: GO:0044252 ! negative regulation of multicellular organismal metabolic process relationship: part_of GO:0042750 ! hibernation [Term] id: GO:0044251 name: protein catabolic process by pepsin namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid)." [GOC:jl, http://www.emc.maricopa.edu/] synonym: "protein breakdown by pepsin" EXACT [] synonym: "protein degradation by pepsin" EXACT [] is_a: GO:0044254 ! multicellular organismal protein catabolic process [Term] id: GO:0044252 name: negative regulation of multicellular organismal metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl] synonym: "down regulation of organismal metabolic process" EXACT [] synonym: "down-regulation of organismal metabolic process" EXACT [] synonym: "downregulation of organismal metabolic process" EXACT [] synonym: "inhibition of organismal metabolic process" NARROW [] synonym: "negative regulation of organismal metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0044246 ! regulation of multicellular organismal metabolic process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0044236 ! multicellular organismal metabolic process [Term] id: GO:0044253 name: positive regulation of multicellular organismal metabolic process namespace: biological_process def: "Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl] synonym: "activation of organismal metabolic process" NARROW [] synonym: "positive regulation of organismal metabolism" EXACT [] synonym: "stimulation of organismal metabolic process" NARROW [] synonym: "up regulation of organismal metabolic process" EXACT [] synonym: "up-regulation of organismal metabolic process" EXACT [] synonym: "upregulation of organismal metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0044246 ! regulation of multicellular organismal metabolic process is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0044236 ! multicellular organismal metabolic process [Term] id: GO:0044254 name: multicellular organismal protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in a multicellular organism, occurring at the tissue, organ, or organismal level." [GOC:jl] synonym: "organismal protein breakdown" EXACT [] synonym: "organismal protein catabolism" EXACT [] synonym: "organismal protein degradation" EXACT [] is_a: GO:0030163 ! protein catabolic process is_a: GO:0044243 ! multicellular organismal catabolic process is_a: GO:0044266 ! multicellular organismal macromolecule catabolic process is_a: GO:0044268 ! multicellular organismal protein metabolic process relationship: part_of GO:0044256 ! protein digestion [Term] id: GO:0044255 name: cellular lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl] subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "cellular lipid metabolism" EXACT [] xref: Reactome:1252948 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1253071 "Peroxisomal lipid metabolism" xref: Reactome:1279882 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1280006 "Peroxisomal lipid metabolism" xref: Reactome:1298794 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1298896 "Peroxisomal lipid metabolism" xref: Reactome:1326451 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1326576 "Peroxisomal lipid metabolism" xref: Reactome:1352567 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1352688 "Peroxisomal lipid metabolism" xref: Reactome:1372794 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1372905 "Peroxisomal lipid metabolism" xref: Reactome:1392804 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1392920 "Peroxisomal lipid metabolism" xref: Reactome:1417281 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1417397 "Peroxisomal lipid metabolism" xref: Reactome:1450370 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1450495 "Peroxisomal lipid metabolism" xref: Reactome:1470953 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1471008 "Peroxisomal lipid metabolism" xref: Reactome:1482941 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1483034 "Peroxisomal lipid metabolism" xref: Reactome:1496763 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1497043 "Peroxisomal lipid metabolism" xref: Reactome:1514153 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1514430 "Peroxisomal lipid metabolism" xref: Reactome:1520943 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1521029 "Peroxisomal lipid metabolism" xref: Reactome:1526732 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1526998 "Peroxisomal lipid metabolism" xref: Reactome:1532455 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1532736 "Peroxisomal lipid metabolism" xref: Reactome:1536001 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1537987 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1538089 "Peroxisomal lipid metabolism" xref: Reactome:1539238 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1539361 "Peroxisomal lipid metabolism" xref: Reactome:1540308 "Fatty acid, triacylglycerol, and ketone body metabolism" xref: Reactome:1540372 "Peroxisomal lipid metabolism" xref: Reactome:390918 "Peroxisomal lipid metabolism" xref: Reactome:535734 "Fatty acid, triacylglycerol, and ketone body metabolism" is_a: GO:0006629 ! lipid metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044256 name: protein digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] is_a: GO:0007586 ! digestion [Term] id: GO:0044257 name: cellular protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:jl] subset: goslim_yeast subset: gosubset_prok synonym: "cellular protein breakdown" EXACT [] synonym: "cellular protein catabolism" EXACT [] synonym: "cellular protein degradation" EXACT [] xref: Reactome:1235701 "Degradation of newly synthesized ApoB-48" xref: Reactome:1262992 "Degradation of newly synthesized ApoB-48" xref: Reactome:1287636 "Degradation of newly synthesized ApoB-48" xref: Reactome:1309311 "Degradation of newly synthesized ApoB-48" xref: Reactome:1336320 "Degradation of newly synthesized ApoB-48" xref: Reactome:1360305 "Degradation of newly synthesized ApoB-48" xref: Reactome:1381101 "Degradation of newly synthesized ApoB-48" xref: Reactome:1402311 "Degradation of newly synthesized ApoB-48" xref: Reactome:1430343 "Degradation of newly synthesized ApoB-48" xref: Reactome:174731 "Degradation of newly synthesized ApoB-48" is_a: GO:0030163 ! protein catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0044258 name: intestinal lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, http://www.emc.maricopa.edu/] synonym: "intestinal lipid breakdown" EXACT [] synonym: "intestinal lipid catabolism" EXACT [] synonym: "intestinal lipid degradation" EXACT [] is_a: GO:0044240 ! multicellular organismal lipid catabolic process [Term] id: GO:0044259 name: multicellular organismal macromolecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl] synonym: "organismal macromolecule metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044236 ! multicellular organismal metabolic process [Term] id: GO:0044260 name: cellular macromolecule metabolic process namespace: biological_process alt_id: GO:0034960 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [CHEBI:33694, GOC:mah] subset: gosubset_prok synonym: "cellular biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044261 name: multicellular organismal carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:jl] synonym: "organismal carbohydrate metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process [Term] id: GO:0044262 name: cellular carbohydrate metabolic process namespace: biological_process alt_id: GO:0006092 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] subset: goslim_yeast subset: gosubset_prok synonym: "cellular carbohydrate metabolism" EXACT [] synonym: "main pathways of carbohydrate metabolic process" NARROW [] synonym: "main pathways of carbohydrate metabolism" NARROW [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044263 name: multicellular organismal polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl] synonym: "organismal glycan metabolic process" EXACT [] synonym: "organismal glycan metabolism" EXACT [] synonym: "organismal polysaccharide metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0044261 ! multicellular organismal carbohydrate metabolic process [Term] id: GO:0044264 name: cellular polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular glycan metabolic process" EXACT [] synonym: "cellular glycan metabolism" EXACT [] synonym: "cellular polysaccharide metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0044265 name: cellular macromolecule catabolic process namespace: biological_process alt_id: GO:0034962 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [CHEBI:33694, GOC:jl] subset: gosubset_prok synonym: "cellular biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule breakdown" EXACT [] synonym: "cellular macromolecule catabolism" EXACT [] synonym: "cellular macromolecule degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0044266 name: multicellular organismal macromolecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl] synonym: "organismal macromolecule breakdown" EXACT [] synonym: "organismal macromolecule catabolism" EXACT [] synonym: "organismal macromolecule degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process [Term] id: GO:0044267 name: cellular protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification." [GOC:jl] subset: gosubset_prok synonym: "cellular protein metabolism" EXACT [] xref: Reactome:1252984 "Metabolism of proteins" xref: Reactome:1279914 "Metabolism of proteins" xref: Reactome:1298813 "Metabolism of proteins" xref: Reactome:1326487 "Metabolism of proteins" xref: Reactome:1352597 "Metabolism of proteins" xref: Reactome:1372829 "Metabolism of proteins" xref: Reactome:1392839 "Metabolism of proteins" xref: Reactome:1417314 "Metabolism of proteins" xref: Reactome:1450400 "Metabolism of proteins" xref: Reactome:1470931 "Metabolism of proteins" xref: Reactome:1482971 "Metabolism of proteins" xref: Reactome:1496744 "Metabolism of proteins" xref: Reactome:1514134 "Metabolism of proteins" xref: Reactome:1520959 "Metabolism of proteins" xref: Reactome:1526712 "Metabolism of proteins" xref: Reactome:1532435 "Metabolism of proteins" xref: Reactome:1535988 "Metabolism of proteins" xref: Reactome:1538032 "Metabolism of proteins" xref: Reactome:392499 "Metabolism of proteins" is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0044268 name: multicellular organismal protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl] synonym: "organismal protein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process [Term] id: GO:0044269 name: glycerol ether catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:jl] subset: gosubset_prok synonym: "glycerol ether breakdown" EXACT [] synonym: "glycerol ether catabolism" EXACT [] synonym: "glycerol ether degradation" EXACT [] is_a: GO:0006662 ! glycerol ether metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0044270 name: cellular nitrogen compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nitrogen compound breakdown" BROAD [] synonym: "nitrogen compound catabolism" BROAD [] synonym: "nitrogen compound degradation" BROAD [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0044271 name: cellular nitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nitrogen compound anabolism" BROAD [] synonym: "nitrogen compound biosynthesis" BROAD [] synonym: "nitrogen compound formation" BROAD [] synonym: "nitrogen compound synthesis" BROAD [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044272 name: sulfur compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] subset: gosubset_prok synonym: "sulfur biosynthesis" NARROW [] synonym: "sulfur biosynthetic process" NARROW [] synonym: "sulfur compound anabolism" EXACT [] synonym: "sulfur compound biosynthesis" EXACT [] synonym: "sulfur compound formation" EXACT [] synonym: "sulfur compound synthesis" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044273 name: sulfur compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] subset: gosubset_prok synonym: "sulfur catabolic process" NARROW [] synonym: "sulfur catabolism" NARROW [] synonym: "sulfur compound breakdown" EXACT [] synonym: "sulfur compound catabolism" EXACT [] synonym: "sulfur compound degradation" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0044274 name: multicellular organismal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:jl] synonym: "organismal anabolism" EXACT [] synonym: "organismal biosynthesis" EXACT [] synonym: "organismal formation" EXACT [] synonym: "organismal synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process [Term] id: GO:0044275 name: cellular carbohydrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular carbohydrate breakdown" EXACT [] synonym: "cellular carbohydrate catabolism" EXACT [] synonym: "cellular carbohydrate degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0044276 name: multicellular organismal carbohydrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl] synonym: "organismal carbohydrate breakdown" EXACT [] synonym: "organismal carbohydrate catabolism" EXACT [] synonym: "organismal carbohydrate degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044243 ! multicellular organismal catabolic process is_a: GO:0044261 ! multicellular organismal carbohydrate metabolic process is_a: GO:0044266 ! multicellular organismal macromolecule catabolic process [Term] id: GO:0044277 name: cell wall disassembly namespace: biological_process def: "A process that results in the breakdown of the cell wall." [GOC:jl] subset: gosubset_prok is_a: GO:0071555 ! cell wall organization [Term] id: GO:0044278 name: cell wall disassembly in other organism namespace: biological_process def: "A process carried out by an organism that results in the breakdown of the cell wall of a second organism." [GOC:jl] is_a: GO:0044277 ! cell wall disassembly [Term] id: GO:0044279 name: other organism membrane namespace: cellular_component def: "A membrane of a secondary organism with which the first organism is interacting." [GOC:jl] subset: gosubset_prok is_a: GO:0044217 ! other organism part [Term] id: GO:0044280 name: subplasmalemmal coating namespace: cellular_component def: "Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier." [NIF_Subcellular:sao1938587839] xref: NIF_Subcellular:sao1938587839 is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0031232 ! extrinsic to external side of plasma membrane [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass." [GOC:curators, GOC:vw] subset: goslim_generic synonym: "small molecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0044282 name: small molecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass." [GOC:curators, GOC:vw] synonym: "small molecule catabolism" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0044283 name: small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass." [GOC:curators, GOC:vw] synonym: "small molecule biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0044284 name: crista junction namespace: cellular_component def: "Tubular structures of relatively uniform size that connect mitochondrial cristae to the inner mitchondrial membrane." [NIF_Subcellular:sao1825845900] xref: NIF_Subcellular:sao1825845900 is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0044285 name: bridge contact site namespace: cellular_component def: "Site of contact between the inner and outer mitochondrial membrane found in neuronal mitochondria; may play a role in maintaining the structural integrity of the inner and outer boundary membranes." [NIF_Subcellular:sao1858501007] xref: NIF_Subcellular:sao1858501007 is_a: GO:0044455 ! mitochondrial membrane part [Term] id: GO:0044286 name: peg and socket contact namespace: cellular_component def: "A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells." [GOC:tfm, NIF_Subcellular:sao1943947957, PMID:12883993, PMID:16166562, PMID:17591898] synonym: "ball and socket contact" EXACT [GOC:tfm, PMID:17591898] xref: NIF_Subcellular:sao1943947957 is_a: GO:0044291 ! cell-cell contact zone [Term] id: GO:0044288 name: puncta adhaerentia namespace: cellular_component def: "A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells." [NIF_Subcellular:sao257629430] xref: NIF_Subcellular:sao257629430 is_a: GO:0005915 ! zonula adherens [Term] id: GO:0044289 name: contact site namespace: cellular_component def: "Sites of close apposition of the inner and outer mitochondrial membrane." [NIF_Subcellular:sao447856407] xref: NIF_Subcellular:sao447856407 is_a: GO:0044455 ! mitochondrial membrane part [Term] id: GO:0044290 name: mitochondrial intracristal space namespace: cellular_component def: "The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space." [NIF_Subcellular:sao508958414] xref: NIF_Subcellular:sao508958414 is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0044291 name: cell-cell contact zone namespace: cellular_component def: "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018] synonym: "cell cell contact zone" EXACT [] xref: NIF_Subcellular:sao1299635018 is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0044292 name: dendrite terminus namespace: cellular_component def: "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134] synonym: "dendrite terminal" EXACT [] synonym: "dendrite terminal specialization" RELATED [] synonym: "terminal specialization of a dendrite" EXACT [] xref: NIF_Subcellular:sao28175134 is_a: GO:0044463 ! cell projection part relationship: part_of GO:0030425 ! dendrite [Term] id: GO:0044293 name: dendriole namespace: cellular_component def: "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, PMID:8300904] xref: NIF_Subcellular:sao28175134 is_a: GO:0044292 ! dendrite terminus [Term] id: GO:0044294 name: dendritic growth cone namespace: cellular_component def: "The migrating motile tip of a growing nerve cell dendrite." [GOC:jl] synonym: "dendrite growth cone" EXACT [] xref: NIF_Subcellular:sao1594955670 is_a: GO:0030426 ! growth cone is_a: GO:0044292 ! dendrite terminus [Term] id: GO:0044295 name: axonal growth cone namespace: cellular_component def: "The migrating motile tip of a growing nerve cell axon." [GOC:jl] synonym: "axon growth cone" EXACT [] xref: NIF_Subcellular:sao1594955670 is_a: GO:0030426 ! growth cone is_a: GO:0033267 ! axon part [Term] id: GO:0044296 name: dendritic tuft namespace: cellular_component def: "The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance." [NIF_Subcellular:sao1340260079] synonym: "dendrite tuft" EXACT [] xref: NIF_Subcellular:sao1340260079 is_a: GO:0044292 ! dendrite terminus [Term] id: GO:0044297 name: cell body namespace: cellular_component def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. subset: goslim_pir synonym: "cell soma" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0044298 name: cell body membrane namespace: cellular_component def: "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections." [GOC:ecd] synonym: "cell soma membrane" EXACT [] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0044297 ! cell body [Term] id: GO:0044299 name: C-fiber namespace: cellular_component def: "The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated." [NIF_Subcellular:nlx_subcell_20090210] synonym: "C-fibre" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090210 is_a: GO:0030424 ! axon [Term] id: GO:0044300 name: cerebellar mossy fiber namespace: cellular_component def: "An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \"mossy\" appearance in Golgi stained preparations." [NIF_Subcellular:nlx_subcell_20090209] synonym: "cerebellar mossy fibre" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090209 is_a: GO:0030424 ! axon [Term] id: GO:0044301 name: climbing fiber namespace: cellular_component def: "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to \"climb\" along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber." [NIF_Subcellular:nlx_subcell_20090203] synonym: "climbing fibre" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090203 is_a: GO:0030424 ! axon [Term] id: GO:0044302 name: dentate gyrus mossy fiber namespace: cellular_component def: "Distinctive, unmyelinated axons produced by granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709] synonym: "dentate gyrus mossy fibre" EXACT [] synonym: "granule cell axon" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090601 is_a: GO:0030424 ! axon [Term] id: GO:0044303 name: axon collateral namespace: cellular_component def: "Any of the smaller branches of an axon that emanate from the main axon cylinder." [NIF_Subcellular:sao1470140754] xref: NIF_Subcellular:sao1470140754 is_a: GO:0033267 ! axon part [Term] id: GO:0044304 name: main axon namespace: cellular_component def: "The main axonal trunk, as opposed to the collaterals." [NIF_Subcellular:sao1596975044] synonym: "axon trunk" EXACT [] xref: NIF_Subcellular:sao1596975044 is_a: GO:0033267 ! axon part [Term] id: GO:0044305 name: calyx of Held namespace: cellular_component def: "The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system." [NIF_Subcellular:sao1684283879, PMID:11823805] xref: NIF_Subcellular:sao1684283879 is_a: GO:0043679 ! axon terminus [Term] id: GO:0044306 name: neuron projection terminus namespace: cellular_component def: "The specialized, terminal region of a neuron projection such as an axon or a dendrite." [GOC:jl] synonym: "neuron projection terminal" EXACT [] synonym: "neuron terminal specialization" EXACT [] is_a: GO:0044463 ! cell projection part relationship: part_of GO:0043005 ! neuron projection [Term] id: GO:0044307 name: dendritic branch namespace: cellular_component def: "A dendrite arising from another dendrite." [NIF_Subcellular:sao884265541] synonym: "dendrite branch" EXACT [] xref: NIF_Subcellular:sao884265541 is_a: GO:0044463 ! cell projection part relationship: part_of GO:0030425 ! dendrite [Term] id: GO:0044308 name: axonal spine namespace: cellular_component def: "A spine that originates from the axon, usually from the initial segment." [NIF_Subcellular:sao18239917] synonym: "axon spine" EXACT [] xref: NIF_Subcellular:sao18239917 is_a: GO:0033267 ! axon part is_a: GO:0044309 ! neuron spine [Term] id: GO:0044309 name: neuron spine namespace: cellular_component def: "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102] xref: NIF_Subcellular:sao1145756102 is_a: GO:0043005 ! neuron projection [Term] id: GO:0044310 name: osmiophilic body namespace: cellular_component def: "A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito." [GOC:jl, PMID:18086189] is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0044311 name: exoneme namespace: cellular_component def: "A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte." [GOC:jl, PMID:18083092, PMID:18083098] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0044312 name: crystalloid namespace: cellular_component def: "A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation." [GOC:jl, PMID:19932717] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0044313 name: protein K6-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein." [GOC:sp] is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0044314 name: protein K27-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein." [PMID:19345326] synonym: "protein K27-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination [Term] id: GO:0044315 name: protein secretion by the type VII secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system." [PMID:17922044, PMID:19876390] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0044316 name: cone cell pedicle namespace: cellular_component def: "A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL)." [http://webvision.med.utah.edu/photo2.html, PMID:10939333] synonym: "cone pedicle" EXACT [] is_a: GO:0043679 ! axon terminus [Term] id: GO:0044317 name: rod spherule namespace: cellular_component def: "A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body." [http://webvision.med.utah.edu/photo2.html] synonym: "rod cell spherule" EXACT [] synonym: "rod photoreceptor spherule" EXACT [] is_a: GO:0043005 ! neuron projection [Term] id: GO:0044318 name: L-aspartate:fumarate oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate." [PMID:20149100] comment: This is based on the finding that L-aspartate oxidase (NadB) of E. coli preferentially uses fumarate as the electron acceptor and does so under anaerobic conditions. The same enzyme uses oxygen as the electron acceptor under aerobic conditions. The EC conflates the two reactions in EC 1.4.3.16 (as they are catalyzed by the same enzyme). xref: EC:1.4.3.16 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0044319 name: wound healing, spreading of cells namespace: biological_process def: "The migration of an cell along or through a wound gap to reestablish a continuous surface." [GOC:jl] is_a: GO:0016477 ! cell migration relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0044320 name: cellular response to leptin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism." [GOC:yaf] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0044321 ! response to leptin stimulus [Term] id: GO:0044321 name: response to leptin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]." [GOC:yaf] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0044322 name: endoplasmic reticulum quality control compartment namespace: cellular_component def: "A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins." [PMID:11408579] synonym: "ER quality control compartment" EXACT [] synonym: "ER-derived quality control compartment" RELATED [] synonym: "ERQC" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0044323 name: retinoic acid-responsive element binding namespace: molecular_function def: "Interacting selectively with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind." [GOC:jl, PMID:11327309, PMID:19917671] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "RARE binding" EXACT [] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0044324 name: regulation of transcription involved in anterior/posterior axis specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis." [GOC:jl] is_a: GO:0006355 ! regulation of transcription, DNA-dependent relationship: part_of GO:0009948 ! anterior/posterior axis specification [Term] id: GO:0044325 name: ion channel binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:BHF, GOC:jl] is_a: GO:0005515 ! protein binding [Term] id: GO:0044326 name: dendritic spine neck namespace: cellular_component def: "Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine." [GOC:nln] is_a: GO:0044463 ! cell projection part relationship: part_of GO:0043197 ! dendritic spine [Term] id: GO:0044327 name: dendritic spine head namespace: cellular_component def: "Distal part of the dendritic spine, that carries the post-synaptic density." [GOC:nln] is_a: GO:0044463 ! cell projection part relationship: part_of GO:0043197 ! dendritic spine [Term] id: GO:0044328 name: canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of endothelial cell migration" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0010595 ! positive regulation of endothelial cell migration [Term] id: GO:0044329 name: canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cell-cell adhesion" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0022409 ! positive regulation of cell-cell adhesion [Term] id: GO:0044330 name: canonical Wnt receptor signaling pathway involved in positive regulation of wound healing namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of wound healing" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0090303 ! positive regulation of wound healing [Term] id: GO:0044331 name: cell-cell adhesion mediated by cadherin namespace: biological_process def: "The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains." [GOC:hgd, GOC:jl, PMID:10923970] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0033627 ! cell adhesion mediated by integrin [Term] id: GO:0044332 name: Wnt receptor signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis." [GOC:jl, GOC:yaf] synonym: "Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0044333 name: Wnt receptor signaling pathway involved in digestive tract morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract." [GOC:BHF, GOC:jl] synonym: "Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0044334 name: canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0010718 ! positive regulation of epithelial to mesenchymal transition [Term] id: GO:0044335 name: canonical Wnt receptor signaling pathway involved in neural crest cell differentiation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0014033 ! neural crest cell differentiation [Term] id: GO:0044336 name: canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptosis." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in negative regulation of apoptosis" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0043066 ! negative regulation of apoptosis [Term] id: GO:0044337 name: canonical Wnt receptor signaling pathway involved in positive regulation of apoptosis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptosis." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of apoptosis" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0043065 ! positive regulation of apoptosis [Term] id: GO:0044338 name: canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in mesenchymal stem cell differentiation" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0072497 ! mesenchymal stem cell differentiation [Term] id: GO:0044339 name: canonical Wnt receptor signaling pathway involved in osteoblast differentiation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0044340 name: canonical Wnt receptor signaling pathway involved in regulation of cell proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signalling pathway involved in regulation of cell proliferation" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0042127 ! regulation of cell proliferation [Term] id: GO:0044341 name: sodium-dependent phosphate transport namespace: biological_process def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl] is_a: GO:0006817 ! phosphate transport [Term] id: GO:0044342 name: type B pancreatic cell proliferation namespace: biological_process def: "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl] synonym: "pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "pancreatic beta cell proliferation" EXACT [] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0044343 name: canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [] synonym: "canonical Wnt receptor signaling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "canonical Wnt receptor signalling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "canonical Wnt receptor signalling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [GOC:mah] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0044340 ! canonical Wnt receptor signaling pathway involved in regulation of cell proliferation relationship: regulates GO:0044342 ! type B pancreatic cell proliferation [Term] id: GO:0044344 name: cellular response to fibroblast growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl] synonym: "cellular response to FGF stimulus" EXACT [] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071774 ! response to fibroblast growth factor stimulus [Term] id: GO:0044345 name: stromal-epithelial cell signaling involved in prostate gland development namespace: biological_process def: "The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development." [GOC:jl] synonym: "stromal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0044346 name: fibroblast apoptosis namespace: biological_process def: "Apoptosis of a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl] is_a: GO:0006915 ! apoptosis [Term] id: GO:0044399 name: multi-species biofilm formation namespace: biological_process def: "A process in which microorganisms of different species attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] subset: gosubset_prok is_a: GO:0042710 ! biofilm formation is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0044400 name: multi-species biofilm formation on inanimate substrate namespace: biological_process def: "A process in which microorganisms of different species attach to and grow on an inanimate surface such as a rock or pipe and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] subset: gosubset_prok is_a: GO:0044399 ! multi-species biofilm formation [Term] id: GO:0044401 name: multi-species biofilm formation in or on host organism namespace: biological_process def: "A process in which microorganisms of different species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0044399 ! multi-species biofilm formation is_a: GO:0044406 ! adhesion to host [Term] id: GO:0044402 name: competition with other organism namespace: biological_process def: "Any process in which an organism within a multispecies community gains an advantage in growth or survival over another organism of a different species in that community." [GOC:cc] subset: gosubset_prok synonym: "competition with another organism" EXACT [GOC:bf] synonym: "interspecies competition" BROAD [] is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0044403 name: symbiosis, encompassing mutualism through parasitism namespace: biological_process alt_id: GO:0043298 alt_id: GO:0044404 def: "An interaction between two organisms living together in more or less intimate association. The term host is usually used for the larger (macro) of the two members of a symbiosis. The smaller (micro) member is called the symbiont organism. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs." [GOC:cc, http://www.free-definition.com] comment: Note that this term encompasses all symbiotic relationships between species along a continuum from mutualism through to parasitism, as outlined in the definition. subset: goslim_generic subset: gosubset_prok synonym: "host-pathogen interaction" RELATED [] synonym: "symbiosis" EXACT [] synonym: "symbiotic interaction" EXACT [] synonym: "symbiotic interaction between host and organism" RELATED [] synonym: "symbiotic interaction between organisms" EXACT [] synonym: "symbiotic interaction between species" EXACT [] synonym: "symbiotic interaction with other non-host organism" RELATED [] is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0044405 name: recognition of host namespace: biological_process def: "The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "detection of host" EXACT [] is_a: GO:0051824 ! recognition of other organism involved in symbiotic interaction is_a: GO:0075136 ! response to host [Term] id: GO:0044406 name: adhesion to host namespace: biological_process def: "The attachment of an organism to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "host adhesion" EXACT [] is_a: GO:0051701 ! interaction with host is_a: GO:0051825 ! adhesion to other organism involved in symbiotic interaction [Term] id: GO:0044407 name: single-species biofilm formation in or on host organism namespace: biological_process def: "A process in which microorganisms of the same species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0044010 ! single-species biofilm formation is_a: GO:0044406 ! adhesion to host [Term] id: GO:0044408 name: growth or development of symbiont on or near host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host ; GO:0044133' and 'development of symbiont on or near host ; GO:0044132'. subset: gosubset_prok synonym: "growth or development of organism on or near host surface" EXACT [] is_obsolete: true replaced_by: GO:0044132 replaced_by: GO:0044133 [Term] id: GO:0044409 name: entry into host namespace: biological_process def: "Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "host invasion" EXACT [] synonym: "invasion into host" EXACT [] synonym: "invasion of host" EXACT [] synonym: "invasive growth" RELATED [] is_a: GO:0051828 ! entry into other organism involved in symbiotic interaction is_a: GO:0052126 ! movement in host environment [Term] id: GO:0044410 name: entry into host through natural portals namespace: biological_process def: "Penetration by an organism into its host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0044409 ! entry into host is_a: GO:0051829 ! entry into other organism through natural portals involved in symbiotic interaction [Term] id: GO:0044411 name: entry into host through host barriers namespace: biological_process def: "Penetration by an organism into its host organism via active breaching of the physical barriers of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0044409 ! entry into host is_a: GO:0051830 ! entry into other organism through barriers of other organism involved in symbiotic interaction [Term] id: GO:0044412 name: growth or development of symbiont in host namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host ; GO:0044114' and 'growth of symbiont in host ; GO:0044117'. subset: gosubset_prok synonym: "growth or development of organism within host" EXACT [] synonym: "growth or development of symbiont within host" EXACT [] synonym: "invasive growth" BROAD [] is_obsolete: true replaced_by: GO:0044114 replaced_by: GO:0044117 [Term] id: GO:0044413 name: avoidance of host defenses namespace: biological_process def: "Any process, either constitutive or induced, by which an organism evades, suppresses or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "avoidance of host defences" EXACT [] is_a: GO:0051832 ! avoidance of defenses of other organism involved in symbiotic interaction is_a: GO:0052200 ! response to host defenses [Term] id: GO:0044414 name: suppression of host defenses namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "negative regulation of host defenses" EXACT [] is_a: GO:0044413 ! avoidance of host defenses is_a: GO:0051833 ! suppression of defenses of other organism involved in symbiotic interaction [Term] id: GO:0044415 name: evasion or tolerance of host defenses namespace: biological_process def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0044413 ! avoidance of host defenses is_a: GO:0051834 ! evasion or tolerance of defenses of other organism involved in symbiotic interaction [Term] id: GO:0044416 name: induction by symbiont of host defense response namespace: biological_process def: "The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "activation of host defense response" EXACT [] is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response [Term] id: GO:0044417 name: translocation of molecules into host namespace: biological_process def: "The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "transport of molecules into host" EXACT [] is_a: GO:0051701 ! interaction with host is_a: GO:0051836 ! translocation of molecules into other organism involved in symbiotic interaction [Term] id: GO:0044418 name: translocation of DNA into host namespace: biological_process def: "The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "transport of DNA into host" EXACT [] is_a: GO:0044417 ! translocation of molecules into host is_a: GO:0051837 ! translocation of DNA into other organism involved in symbiotic interaction [Term] id: GO:0044419 name: interspecies interaction between organisms namespace: biological_process def: "Any process in which an organism has an effect on an organism of a different species." [GOC:cc] subset: goslim_candida subset: goslim_pir subset: gosubset_prok synonym: "interaction with another species" EXACT [] synonym: "interspecies interaction" EXACT [] synonym: "interspecies interaction with other organisms" EXACT [] is_a: GO:0051704 ! multi-organism process [Term] id: GO:0044420 name: extracellular matrix part namespace: cellular_component def: "Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl] subset: gosubset_prok is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0031012 ! extracellular matrix [Term] id: GO:0044421 name: extracellular region part namespace: cellular_component def: "Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl] subset: gosubset_prok is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0044422 name: organelle part namespace: cellular_component def: "Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl] subset: gosubset_prok is_a: GO:0005575 ! cellular_component relationship: part_of GO:0043226 ! organelle [Term] id: GO:0044423 name: virion part namespace: cellular_component def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0019012 ! virion [Term] id: GO:0044424 name: intracellular part namespace: cellular_component def: "Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl] subset: gosubset_prok is_a: GO:0044464 ! cell part relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0044425 name: membrane part namespace: cellular_component def: "Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl] subset: gosubset_prok is_a: GO:0044464 ! cell part relationship: part_of GO:0016020 ! membrane [Term] id: GO:0044426 name: cell wall part namespace: cellular_component def: "Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl] subset: gosubset_prok is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0005618 ! cell wall [Term] id: GO:0044427 name: chromosomal part namespace: cellular_component def: "Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl] subset: gosubset_prok synonym: "chromosomal component" EXACT [] synonym: "chromosome component" EXACT [] synonym: "chromosome part" EXACT [] is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0044428 name: nuclear part namespace: cellular_component def: "Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl] synonym: "nucleus component" EXACT [] is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0044429 name: mitochondrial part namespace: cellular_component def: "Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl] synonym: "mitochondrion component" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005739 ! mitochondrion [Term] id: GO:0044430 name: cytoskeletal part namespace: cellular_component def: "Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl] synonym: "cytoskeleton component" EXACT [] is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0044431 name: Golgi apparatus part namespace: cellular_component def: "Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] synonym: "Golgi component" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0044432 name: endoplasmic reticulum part namespace: cellular_component def: "Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl] synonym: "ER component" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0044433 name: cytoplasmic vesicle part namespace: cellular_component def: "Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl] subset: gosubset_prok is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0044434 name: chloroplast part namespace: cellular_component def: "Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl] is_a: GO:0044435 ! plastid part relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0044435 name: plastid part namespace: cellular_component def: "Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl] subset: gosubset_prok is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0009536 ! plastid [Term] id: GO:0044436 name: thylakoid part namespace: cellular_component def: "Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl] subset: gosubset_prok is_a: GO:0044424 ! intracellular part relationship: part_of GO:0009579 ! thylakoid [Term] id: GO:0044437 name: vacuolar part namespace: cellular_component def: "Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl] subset: gosubset_prok synonym: "vacuole component" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0044438 name: microbody part namespace: cellular_component def: "Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0042579 ! microbody [Term] id: GO:0044439 name: peroxisomal part namespace: cellular_component def: "Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl] synonym: "peroxisome component" EXACT [] is_a: GO:0044438 ! microbody part relationship: part_of GO:0005777 ! peroxisome [Term] id: GO:0044440 name: endosomal part namespace: cellular_component def: "Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered." [GOC:mah, PMID:19696797] synonym: "endosome component" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005768 ! endosome [Term] id: GO:0044441 name: cilium part namespace: cellular_component def: "Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:jl] is_a: GO:0044446 ! intracellular organelle part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0005929 ! cilium [Term] id: GO:0044442 name: microtubule-based flagellum part namespace: cellular_component def: "Any constituent part of a microtubule-based flagellum, a long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules. Examples of this component are found in Mus musculus." [GOC:jl, GOC:mtg_sensu] synonym: "flagellar part" BROAD [] is_a: GO:0044446 ! intracellular organelle part is_a: GO:0044460 ! flagellum part relationship: part_of GO:0009434 ! microtubule-based flagellum [Term] id: GO:0044443 name: pilus part namespace: cellular_component def: "Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators] subset: gosubset_prok synonym: "fimbrial part" EXACT [] synonym: "fimbrium component" EXACT [] synonym: "pilus component" EXACT [] is_a: GO:0044446 ! intracellular organelle part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0009289 ! pilus [Term] id: GO:0044444 name: cytoplasmic part namespace: cellular_component def: "Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl] subset: gosubset_prok synonym: "cytoplasm component" EXACT [] is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0044445 name: cytosolic part namespace: cellular_component def: "Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl] subset: gosubset_prok synonym: "cytosol component" EXACT [] is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0044446 name: intracellular organelle part namespace: cellular_component def: "A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl] subset: gosubset_prok is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0044447 name: axoneme part namespace: cellular_component def: "Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [GOC:jl] is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0005930 ! axoneme [Term] id: GO:0044448 name: cell cortex part namespace: cellular_component def: "Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl] is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0044449 name: contractile fiber part namespace: cellular_component def: "Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl] synonym: "contractile fibre component" EXACT [] synonym: "muscle fiber component" BROAD [] synonym: "muscle fibre component" BROAD [] is_a: GO:0044422 ! organelle part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0043292 ! contractile fiber [Term] id: GO:0044450 name: microtubule organizing center part namespace: cellular_component def: "Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl] synonym: "microtubule organizing centre component" EXACT [] synonym: "MTOC component" EXACT [] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0005815 ! microtubule organizing center [Term] id: GO:0044451 name: nucleoplasm part namespace: cellular_component def: "Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl] is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0044452 name: nucleolar part namespace: cellular_component def: "Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl] synonym: "nucleolus component" EXACT [] is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0044453 name: nuclear membrane part namespace: cellular_component def: "Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl] is_a: GO:0044425 ! membrane part is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031965 ! nuclear membrane [Term] id: GO:0044454 name: nuclear chromosome part namespace: cellular_component def: "Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell." [GOC:jl] is_a: GO:0044427 ! chromosomal part is_a: GO:0044428 ! nuclear part relationship: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0044455 name: mitochondrial membrane part namespace: cellular_component def: "Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl] is_a: GO:0044425 ! membrane part is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0031966 ! mitochondrial membrane [Term] id: GO:0044456 name: synapse part namespace: cellular_component def: "Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0045202 ! synapse [Term] id: GO:0044457 name: cell septum part namespace: cellular_component def: "Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl] is_a: GO:0044464 ! cell part relationship: part_of GO:0030428 ! cell septum [Term] id: GO:0044459 name: plasma membrane part namespace: cellular_component def: "Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl] subset: gosubset_prok is_a: GO:0044425 ! membrane part relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0044460 name: flagellum part namespace: cellular_component def: "Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl] subset: gosubset_prok synonym: "flagellum component" EXACT [] is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0019861 ! flagellum [Term] id: GO:0044461 name: bacterial-type flagellum part namespace: cellular_component def: "Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. Examples of this component are found in bacterial species." [GOC:jl, GOC:mtg_sensu] subset: gosubset_prok synonym: "flagellin-based flagellum part" EXACT [] is_a: GO:0044460 ! flagellum part relationship: part_of GO:0009288 ! bacterial-type flagellum [Term] id: GO:0044462 name: external encapsulating structure part namespace: cellular_component def: "Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:jl] subset: gosubset_prok is_a: GO:0044464 ! cell part relationship: part_of GO:0030312 ! external encapsulating structure [Term] id: GO:0044463 name: cell projection part namespace: cellular_component def: "Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl] subset: gosubset_prok is_a: GO:0044464 ! cell part relationship: part_of GO:0042995 ! cell projection [Term] id: GO:0044464 name: cell part namespace: cellular_component def: "Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "protoplast" RELATED [GOC:mah] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005623 ! cell [Term] id: GO:0045002 name: double-strand break repair via single-strand annealing namespace: biological_process def: "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529] subset: gosubset_prok is_a: GO:0000726 ! non-recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0045003 name: double-strand break repair via synthesis-dependent strand annealing namespace: biological_process def: "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855] subset: gosubset_prok synonym: "mitotic gene conversion" RELATED [] synonym: "SDSA" BROAD [] xref: Reactome:83667 "Resolution of D-loop structures through synthesis-dependent strand-annealing" is_a: GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0045004 name: DNA replication proofreading namespace: biological_process def: "Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai] subset: gosubset_prok is_a: GO:0006281 ! DNA repair is_a: GO:0045005 ! maintenance of fidelity involved in DNA-dependent DNA replication [Term] id: GO:0045005 name: maintenance of fidelity involved in DNA-dependent DNA replication namespace: biological_process def: "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw] subset: gosubset_prok synonym: "maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0045006 name: DNA deamination namespace: biological_process def: "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil." [GOC:ai] subset: gosubset_prok is_a: GO:0006304 ! DNA modification [Term] id: GO:0045007 name: depurination namespace: biological_process def: "The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar." [GOC:ai] subset: gosubset_prok xref: Reactome:110330 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:110331 "Cleavage of the damaged purine" xref: Reactome:1253174 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1253175 "Depurination" xref: Reactome:1253176 "Cleavage of the damaged purine" xref: Reactome:1280107 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1280108 "Depurination" xref: Reactome:1280109 "Cleavage of the damaged purine" xref: Reactome:1298988 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1298989 "Depurination" xref: Reactome:1298990 "Cleavage of the damaged purine" xref: Reactome:1326679 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1326680 "Depurination" xref: Reactome:1326681 "Cleavage of the damaged purine" xref: Reactome:1352791 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1352792 "Depurination" xref: Reactome:1352793 "Cleavage of the damaged purine" xref: Reactome:1373001 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1373002 "Depurination" xref: Reactome:1373003 "Cleavage of the damaged purine" xref: Reactome:1393017 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1393018 "Depurination" xref: Reactome:1393019 "Cleavage of the damaged purine" xref: Reactome:1417494 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1417495 "Depurination" xref: Reactome:1417496 "Cleavage of the damaged purine" xref: Reactome:1450591 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1450592 "Depurination" xref: Reactome:1450593 "Cleavage of the damaged purine" xref: Reactome:1471098 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1471099 "Depurination" xref: Reactome:1471100 "Cleavage of the damaged purine" xref: Reactome:1496835 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1496836 "Depurination" xref: Reactome:1496837 "Cleavage of the damaged purine" xref: Reactome:1514229 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1514230 "Depurination" xref: Reactome:1514231 "Cleavage of the damaged purine" xref: Reactome:1521068 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1521069 "Depurination" xref: Reactome:1521070 "Cleavage of the damaged purine" xref: Reactome:1526837 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1526838 "Depurination" xref: Reactome:1526839 "Cleavage of the damaged purine" xref: Reactome:1532563 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1532564 "Depurination" xref: Reactome:1532565 "Cleavage of the damaged purine" xref: Reactome:1536036 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1536037 "Depurination" xref: Reactome:1536038 "Cleavage of the damaged purine" xref: Reactome:1538024 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1538025 "Depurination" xref: Reactome:1538026 "Cleavage of the damaged purine" xref: Reactome:1539286 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1539287 "Depurination" xref: Reactome:1539288 "Cleavage of the damaged purine" xref: Reactome:1540324 "Recognition and association of DNA glycosylase with site containing an affected purine" xref: Reactome:1540325 "Depurination" xref: Reactome:1540326 "Cleavage of the damaged purine" xref: Reactome:73927 "Depurination" xref: Wikipedia:Depurination is_a: GO:0006285 ! base-excision repair, AP site formation is_a: GO:0006304 ! DNA modification is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process [Term] id: GO:0045008 name: depyrimidination namespace: biological_process def: "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar." [GOC:ai] subset: gosubset_prok xref: Reactome:110328 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:110329 "Cleavage of the damaged pyrimidine" xref: Reactome:1253170 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1253171 "Depyrimidination" xref: Reactome:1253173 "Cleavage of the damaged pyrimidine" xref: Reactome:1280103 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1280104 "Depyrimidination" xref: Reactome:1280106 "Cleavage of the damaged pyrimidine" xref: Reactome:1298983 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1298984 "Depyrimidination" xref: Reactome:1298987 "Cleavage of the damaged pyrimidine" xref: Reactome:1326675 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1326676 "Depyrimidination" xref: Reactome:1326678 "Cleavage of the damaged pyrimidine" xref: Reactome:1352787 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1352788 "Depyrimidination" xref: Reactome:1352790 "Cleavage of the damaged pyrimidine" xref: Reactome:1372996 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1372997 "Depyrimidination" xref: Reactome:1373000 "Cleavage of the damaged pyrimidine" xref: Reactome:1393012 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1393013 "Depyrimidination" xref: Reactome:1393016 "Cleavage of the damaged pyrimidine" xref: Reactome:1417490 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1417491 "Depyrimidination" xref: Reactome:1417493 "Cleavage of the damaged pyrimidine" xref: Reactome:1450587 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1450588 "Depyrimidination" xref: Reactome:1450590 "Cleavage of the damaged pyrimidine" xref: Reactome:1471093 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1471094 "Depyrimidination" xref: Reactome:1471097 "Cleavage of the damaged pyrimidine" xref: Reactome:1483109 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1483110 "Depyrimidination" xref: Reactome:1483113 "Cleavage of the damaged pyrimidine" xref: Reactome:1496830 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1496831 "Depyrimidination" xref: Reactome:1496834 "Cleavage of the damaged pyrimidine" xref: Reactome:1514224 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1514225 "Depyrimidination" xref: Reactome:1514228 "Cleavage of the damaged pyrimidine" xref: Reactome:1521064 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1521065 "Depyrimidination" xref: Reactome:1521067 "Cleavage of the damaged pyrimidine" xref: Reactome:1526832 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1526833 "Depyrimidination" xref: Reactome:1526836 "Cleavage of the damaged pyrimidine" xref: Reactome:1532558 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1532559 "Depyrimidination" xref: Reactome:1532562 "Cleavage of the damaged pyrimidine" xref: Reactome:1536031 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1536032 "Depyrimidination" xref: Reactome:1536035 "Cleavage of the damaged pyrimidine" xref: Reactome:1538019 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1538020 "Depyrimidination" xref: Reactome:1538023 "Cleavage of the damaged pyrimidine" xref: Reactome:1539281 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1539282 "Depyrimidination" xref: Reactome:1539285 "Cleavage of the damaged pyrimidine" xref: Reactome:1540319 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine" xref: Reactome:1540320 "Depyrimidination" xref: Reactome:1540323 "Cleavage of the damaged pyrimidine" xref: Reactome:73928 "Depyrimidination" is_a: GO:0006285 ! base-excision repair, AP site formation is_a: GO:0006304 ! DNA modification is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process [Term] id: GO:0045009 name: chitosome namespace: cellular_component def: "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:8970154] is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0045010 name: actin nucleation namespace: biological_process def: "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194] synonym: "actin filament nucleation" EXACT [] is_a: GO:0007015 ! actin filament organization is_a: GO:0030838 ! positive regulation of actin filament polymerization [Term] id: GO:0045012 name: MHC class II receptor activity namespace: molecular_function def: "OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes." [ISBN:081533642X, ISBN:0879694971] comment: This term was made obsolete because it was defined ambiguously, and has therefore been used incorrectly in annotations. To update annotations of gene products that act as receptors for MHC class II protein complexes, use the molecular function term 'MHC class II receptor activity ; GO:0032395'; to update annotations of gene products which are components of MHC class II protein complexes, use the cellular component term 'MHC class II protein complex ; GO:0042613'. synonym: "class II major histocompatibility complex antigen" RELATED [] synonym: "major histocompatibility complex class II receptor" EXACT [] is_obsolete: true consider: GO:0032395 consider: GO:0042613 [Term] id: GO:0045013 name: carbon catabolite repression of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11018147, PMID:18359269, PMID:9618445] subset: gosubset_prok synonym: "carbon catabolite repression" EXACT [] synonym: "negative regulation of transcription by carbon catabolites" EXACT [GOC:mah] is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0045014 name: negative regulation of transcription by glucose namespace: biological_process def: "Any process involving glucose that stops, prevents or reduces the rate of transcription. The presence of glucose in the growth medium inhibits the synthesis of certain enzymes in bacteria growing on the medium. For example, transcription of some catabolic operons is under negative control by specific repressors and glucose is an anti-inducer of xylose utilization and glycerol kinase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11018147] subset: gosubset_prok synonym: "down regulation of transcription by glucose" EXACT [] synonym: "down-regulation of transcription by glucose" EXACT [] synonym: "downregulation of transcription by glucose" EXACT [] synonym: "glucose effect" EXACT [] synonym: "glucose repression" EXACT [] synonym: "inhibition of transcription by glucose" NARROW [] is_a: GO:0045013 ! carbon catabolite repression of transcription is_a: GO:0046015 ! regulation of transcription by glucose [Term] id: GO:0045015 name: HDEL sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [PMID:1327759] synonym: "HDEL receptor activity" NARROW [] is_a: GO:0046923 ! ER retention sequence binding [Term] id: GO:0045016 name: mitochondrial magnesium ion transport namespace: biological_process def: "The transport of magnesium ions (Mg2+) into, out of or within a mitochondrion. Transport across the mitochondrial membranes is mediated by a mitochondrial inner membrane protein." [GOC:ai, PMID:11254124] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015693 ! magnesium ion transport [Term] id: GO:0045017 name: glycerolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] subset: gosubset_prok synonym: "glycerolipid anabolism" EXACT [] synonym: "glycerolipid biosynthesis" EXACT [] synonym: "glycerolipid formation" EXACT [] synonym: "glycerolipid synthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0045018 name: retrograde transport, vacuole to Golgi namespace: biological_process def: "The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment." [PMID:9700156] synonym: "retrograde transport from the vacuole" EXACT [] is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0045019 name: negative regulation of nitric oxide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] synonym: "down regulation of nitric oxide biosynthetic process" EXACT [] synonym: "down-regulation of nitric oxide biosynthetic process" EXACT [] synonym: "downregulation of nitric oxide biosynthetic process" EXACT [] synonym: "inhibition of nitric oxide biosynthetic process" NARROW [] synonym: "negative regulation of nitric oxide anabolism" EXACT [] synonym: "negative regulation of nitric oxide biosynthesis" EXACT [] synonym: "negative regulation of nitric oxide formation" EXACT [] synonym: "negative regulation of nitric oxide synthesis" EXACT [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process relationship: negatively_regulates GO:0006809 ! nitric oxide biosynthetic process [Term] id: GO:0045020 name: error-prone DNA repair namespace: biological_process def: "OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate." [GOC:jl, PMID:11459974] comment: This term was made obsolete because 'error-prone' does not correspond to a repair mechanism, and the term has been superseded by more specific terms. synonym: "mutagenic DNA repair" EXACT [] is_obsolete: true consider: GO:0042276 [Term] id: GO:0045021 name: error-free DNA repair namespace: biological_process def: "OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways." [GOC:jl, PMID:11459974] comment: This term was made obsolete because 'error-free' does not correspond to a repair mechanism, and the term has been superseded by more specific terms. subset: gosubset_prok is_obsolete: true consider: GO:0042275 consider: GO:0070987 [Term] id: GO:0045022 name: early endosome to late endosome transport namespace: biological_process def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194] is_a: GO:0016197 ! endosome transport [Term] id: GO:0045023 name: G0 to G1 transition namespace: biological_process def: "The transition from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [ISBN:0716731363] is_a: GO:0000320 ! re-entry into mitotic cell cycle [Term] id: GO:0045024 name: peptidyl-glutamyl peptide hydrolyzing enzyme activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0070011 [Term] id: GO:0045025 name: mitochondrial degradosome namespace: cellular_component def: "The mitochondrial degradosome (mtEXO) is a three-protein complex which has a 3' to 5' exoribonuclease activity and participates in intron-independent turnover and processing of mitochondrial transcripts." [PMID:10397341, PMID:9829834] is_a: GO:0000177 ! cytoplasmic exosome (RNase complex) is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0045026 name: plasma membrane fusion namespace: biological_process alt_id: GO:0006947 def: "The joining of two or more lipid bilayer membranes that surround a cell." [GOC:elh, GOC:mtg_muscle] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" BROAD [] is_a: GO:0006944 ! cellular membrane fusion [Term] id: GO:0045027 name: DNA end binding namespace: molecular_function def: "Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs)." [GOC:jl] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0045028 name: purinergic nucleotide receptor activity, G-protein coupled namespace: molecular_function def: "Combining with a purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:mah, PMID:9755289] synonym: "G protein coupled purinergic nucleotide receptor activity" EXACT [] synonym: "G-protein coupled purinergic nucleotide receptor activity" EXACT [] synonym: "G-protein-coupled purinergic nucleotide receptor activity" EXACT [] synonym: "P2Y" RELATED [] synonym: "P2Y receptor" RELATED [PMID:9755289] synonym: "purinergic nucleotide receptor activity, G protein coupled" EXACT [] is_a: GO:0001608 ! nucleotide receptor activity, G-protein coupled is_a: GO:0001614 ! purinergic nucleotide receptor activity [Term] id: GO:0045029 name: UDP-activated nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP." [GOC:mah] is_a: GO:0015065 ! uridine nucleotide receptor activity [Term] id: GO:0045030 name: UTP-activated nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP." [GOC:mah] is_a: GO:0015065 ! uridine nucleotide receptor activity [Term] id: GO:0045031 name: ATP-activated nucleotide receptor activity namespace: molecular_function def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ATP." [GOC:mah] is_a: GO:0001609 ! adenosine receptor activity, G-protein coupled [Term] id: GO:0045032 name: ADP-activated nucleotide receptor activity namespace: molecular_function def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ADP." [GOC:mah] is_a: GO:0001609 ! adenosine receptor activity, G-protein coupled [Term] id: GO:0045033 name: peroxisome inheritance namespace: biological_process def: "The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p." [PMID:11733545] comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. is_a: GO:0007031 ! peroxisome organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0045034 name: neuroblast division namespace: biological_process alt_id: GO:0043345 alt_id: GO:0043346 def: "OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell." [PMID:11163136, PMID:11250167] comment: This term was made obsolete because the definition was incorrect. Not all neuroblasts divide asymmetrically. Neuroblasts give rise to neurons after division. synonym: "neuroblast cell division" EXACT [] synonym: "neuroblast division (sensu Nematoda and Protostomia)" EXACT [] synonym: "neuroblast division (sensu Vertebrata)" EXACT [] is_obsolete: true [Term] id: GO:0045035 name: sensory organ precursor cell division namespace: biological_process def: "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] synonym: "sense organ precursor cell division" EXACT [GOC:dph] is_a: GO:0008356 ! asymmetric cell division relationship: part_of GO:0007423 ! sensory organ development [Term] id: GO:0045036 name: protein targeting to chloroplast namespace: biological_process def: "The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved." [ISBN:0716731363] synonym: "protein-chloroplast targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0072596 ! establishment of protein localization to chloroplast [Term] id: GO:0045037 name: protein import into chloroplast stroma namespace: biological_process def: "The import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363] synonym: "chloroplast stroma protein import" EXACT [] synonym: "protein transport into chloroplast stroma" EXACT [] is_a: GO:0017038 ! protein import is_a: GO:0045036 ! protein targeting to chloroplast is_a: GO:0065002 ! intracellular protein transmembrane transport [Term] id: GO:0045038 name: protein import into chloroplast thylakoid membrane namespace: biological_process def: "The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma." [ISBN:0716731363] synonym: "chloroplast thylakoid membrane protein import" EXACT [] synonym: "protein transport into chloroplast thylakoid membrane" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0017038 ! protein import is_a: GO:0045036 ! protein targeting to chloroplast is_a: GO:0065002 ! intracellular protein transmembrane transport [Term] id: GO:0045039 name: protein import into mitochondrial inner membrane namespace: biological_process def: "The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known." [ISBN:0716731363] synonym: "mitochondrial inner membrane protein import" EXACT [] synonym: "protein transport into mitochondrial inner membrane" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0006626 ! protein targeting to mitochondrion is_a: GO:0007007 ! inner mitochondrial membrane organization [Term] id: GO:0045040 name: protein import into mitochondrial outer membrane namespace: biological_process def: "The import of proteins into the outer membrane of the mitochondrion. Outer membrane proteins have a short matrix-targeting sequence followed by a long stretch of hydrophobic amino acids at the N-terminus. The hydrophobic sequence functions as a stop-transfer sequence that both prevents transfer of the protein into the matrix and anchors it as an integral protein in the outer membrane." [ISBN:0716731363] synonym: "mitochondrial outer membrane protein import" EXACT [] synonym: "protein transport into mitochondrial outer membrane" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0006626 ! protein targeting to mitochondrion is_a: GO:0007008 ! outer mitochondrial membrane organization [Term] id: GO:0045041 name: protein import into mitochondrial intermembrane space namespace: biological_process alt_id: GO:0045043 alt_id: GO:0045044 def: "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363] synonym: "mitochondrial intermembrane space protein import" EXACT [] synonym: "protein import into mitochondrial IMS" EXACT [] synonym: "protein import into mitochondrial intermembrane space, direct" NARROW [GOC:mcc] synonym: "protein import into mitochondrial intermembrane space, nonconservative" NARROW [GOC:mcc] synonym: "protein transport into mitochondrial IMS" EXACT [] synonym: "protein transport into mitochondrial intermembrane space" EXACT [] is_a: GO:0006626 ! protein targeting to mitochondrion is_a: GO:0065002 ! intracellular protein transmembrane transport [Term] id: GO:0045042 name: protein import into mitochondrial intermembrane space, conservative namespace: biological_process def: "OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space." [ISBN:0716731363] comment: This term was made obsolete because there is no 'conservative' process of protein import into the mitochondrial intermembrane space that is distinct from the more general parent; furthermore, 'conservative' is used in the literature to describe a pathway of import into the inner membrane rather than into the intermembrane space. synonym: "conservative mitochondrial IMS protein import" EXACT [] synonym: "conservative mitochondrial intermembrane space protein import" EXACT [] synonym: "conservative protein transport into mitochondrial IMS" EXACT [] synonym: "conservative protein transport into mitochondrial intermembrane space" EXACT [] synonym: "protein import into mitochondrial IMS, conservative" EXACT [] synonym: "protein transport into mitochondrial IMS, conservative" EXACT [] synonym: "protein transport into mitochondrial intermembrane space, conservative" EXACT [] is_obsolete: true consider: GO:0045039 consider: GO:0045041 [Term] id: GO:0045045 name: secretory pathway namespace: biological_process def: "OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane." [ISBN:0716731363] comment: This term was made obsolete because it artificially groups a number of other terms, leading to path problems, its definition is unclear (and lacks genus-differentia features), and it has probably been used incorrectly in annotations. is_obsolete: true replaced_by: GO:0032940 [Term] id: GO:0045046 name: protein import into peroxisome membrane namespace: biological_process def: "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502] synonym: "peroxisome membrane protein import" EXACT [] synonym: "protein transport into peroxisome membrane" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0006625 ! protein targeting to peroxisome is_a: GO:0017038 ! protein import [Term] id: GO:0045047 name: protein targeting to ER namespace: biological_process def: "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363] synonym: "protein targeting to endoplasmic reticulum" EXACT [] synonym: "protein-endoplasmic reticulum targeting" EXACT [] synonym: "protein-ER targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0072599 ! establishment of protein localization in endoplasmic reticulum [Term] id: GO:0045048 name: protein insertion into ER membrane namespace: biological_process def: "The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363] synonym: "integral ER membrane protein localization" EXACT [] synonym: "integral ER membrane protein positioning" EXACT [] synonym: "localization of protein in ER membrane" EXACT [] synonym: "positioning of protein in ER membrane" EXACT [] synonym: "protein insertion into endoplasmic reticulum membrane" EXACT [] synonym: "protein-endoplasmic reticulum insertion" EXACT [] synonym: "protein-ER insertion" EXACT [] is_a: GO:0033365 ! protein localization to organelle is_a: GO:0051205 ! protein insertion into membrane relationship: part_of GO:0007029 ! endoplasmic reticulum organization [Term] id: GO:0045049 name: protein insertion into ER membrane by N-terminal cleaved signal sequence namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER." [ISBN:0716731363] synonym: "N-terminal cleaved signal sequence mediated protein insertion into ER membrane" EXACT [] synonym: "protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence" EXACT [] synonym: "protein insertion into ER membrane, N-terminal cleaved signal sequence mediated" EXACT [] synonym: "protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence" EXACT [] synonym: "protein-ER insertion by N-terminal cleaved signal sequence" EXACT [] is_a: GO:0045048 ! protein insertion into ER membrane [Term] id: GO:0045050 name: protein insertion into ER membrane by stop-transfer membrane-anchor sequence namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix." [ISBN:0716731363] synonym: "protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence" EXACT [] synonym: "protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated" EXACT [] synonym: "protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence" EXACT [] synonym: "protein-ER insertion by stop-transfer membrane-anchor sequence" EXACT [] synonym: "stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane" EXACT [] is_a: GO:0045048 ! protein insertion into ER membrane [Term] id: GO:0045051 name: protein insertion into ER membrane by internal uncleaved signal-anchor sequence namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences." [ISBN:0716731363] synonym: "internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane" EXACT [] synonym: "protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence" EXACT [] synonym: "protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated" EXACT [] synonym: "protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence" EXACT [] synonym: "protein-ER insertion by internal uncleaved signal-anchor sequence" EXACT [] is_a: GO:0045048 ! protein insertion into ER membrane [Term] id: GO:0045052 name: protein insertion into ER membrane by GPI attachment sequence namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule." [ISBN:0716731363] synonym: "GPI attachment sequence mediated protein insertion into ER membrane" EXACT [] synonym: "protein insertion into endoplasmic reticulum membrane by GPI attachment sequence" EXACT [] synonym: "protein insertion into ER membrane, GPI attachment sequence mediated" EXACT [] synonym: "protein-endoplasmic reticulum insertion by GPI attachment sequence" EXACT [] synonym: "protein-ER insertion by GPI attachment sequence" EXACT [] is_a: GO:0045048 ! protein insertion into ER membrane [Term] id: GO:0045053 name: protein retention in Golgi apparatus namespace: biological_process def: "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363] synonym: "maintenance of protein location in Golgi apparatus" RELATED [] synonym: "protein-Golgi retention" EXACT [] synonym: "retention of protein in Golgi" EXACT [] is_a: GO:0032507 ! maintenance of protein location in cell relationship: part_of GO:0034067 ! protein localization in Golgi apparatus [Term] id: GO:0045054 name: constitutive secretory pathway namespace: biological_process def: "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space." [GOC:mah, ISBN:0716731363] is_a: GO:0006887 ! exocytosis [Term] id: GO:0045055 name: regulated secretory pathway namespace: biological_process def: "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363] is_a: GO:0006887 ! exocytosis [Term] id: GO:0045056 name: transcytosis namespace: biological_process def: "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [ISBN:0716731363] xref: Wikipedia:Transcytosis is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0045057 name: cisternal progression namespace: biological_process def: "The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna." [ISBN:0716731363] synonym: "cisternal maturation" EXACT [] is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport [Term] id: GO:0045058 name: T cell selection namespace: biological_process def: "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] synonym: "T lymphocyte selection" EXACT [] synonym: "T-cell selection" EXACT [] synonym: "T-lymphocyte selection" EXACT [] xref: Wikipedia:Thymocyte is_a: GO:0002376 ! immune system process relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0045059 name: positive thymic T cell selection namespace: biological_process def: "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] synonym: "positive thymic T lymphocyte selection" EXACT [] synonym: "positive thymic T-cell selection" EXACT [] synonym: "positive thymic T-lymphocyte selection" EXACT [] is_a: GO:0043368 ! positive T cell selection is_a: GO:0045061 ! thymic T cell selection [Term] id: GO:0045060 name: negative thymic T cell selection namespace: biological_process def: "The process of elimination of immature T cells in the thymus which react strongly with self-antigens." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] synonym: "negative thymic T lymphocyte selection" EXACT [] synonym: "negative thymic T-cell selection" EXACT [] synonym: "negative thymic T-lymphocyte selection" EXACT [] is_a: GO:0043383 ! negative T cell selection is_a: GO:0045061 ! thymic T cell selection [Term] id: GO:0045061 name: thymic T cell selection namespace: biological_process def: "The process of T cell selection that occurs in the thymus." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] synonym: "thymic T lymphocyte selection" EXACT [] synonym: "thymic T-cell selection" EXACT [] synonym: "thymic T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection relationship: part_of GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0045062 name: extrathymic T cell selection namespace: biological_process def: "The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus." [ISBN:0781735149 "Fundamental Immunology", PMID:7880383] synonym: "extrathymic T lymphocyte selection" EXACT [] synonym: "extrathymic T-cell selection" EXACT [] synonym: "extrathymic T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection relationship: part_of GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0045063 name: T-helper 1 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:ebc] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T-helper 1 cell development" RELATED [GOC:add] is_a: GO:0042093 ! T-helper cell differentiation relationship: part_of GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0045064 name: T-helper 2 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [CL:0000546, GOC:ebc] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T-helper 2 cell development" RELATED [GOC:add] is_a: GO:0042093 ! T-helper cell differentiation relationship: part_of GO:0042092 ! type 2 immune response [Term] id: GO:0045065 name: cytotoxic T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "cytotoxic T cell development" RELATED [GOC:add] synonym: "cytotoxic T lymphocyte selection" EXACT [] synonym: "cytotoxic T-cell selection" EXACT [] synonym: "cytotoxic T-lymphocyte selection" EXACT [] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0045066 name: regulatory T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulatory T cell development" RELATED [GOC:add] synonym: "regulatory T lymphocyte differentiation" EXACT [] synonym: "regulatory T-cell differentiation" EXACT [] synonym: "regulatory T-lymphocyte differentiation" EXACT [] synonym: "suppressor T cell differentiation" EXACT [] synonym: "suppressor T lymphocyte differentiation" EXACT [] synonym: "suppressor T-cell differentiation" EXACT [] synonym: "suppressor T-lymphocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0045067 name: positive extrathymic T cell selection namespace: biological_process def: "The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149 "Fundamental Immunology", PMID:7880383] synonym: "positive extrathymic T cell selection" RELATED [GOC:add] synonym: "positive extrathymic T lymphocyte selection" EXACT [] synonym: "positive extrathymic T-cell selection" EXACT [] synonym: "positive extrathymic T-lymphocyte selection" EXACT [] is_a: GO:0043368 ! positive T cell selection is_a: GO:0045062 ! extrathymic T cell selection [Term] id: GO:0045068 name: negative extrathymic T cell selection namespace: biological_process def: "The process of elimination of extrathymically maturing T cells which react strongly with self-antigens." [ISBN:0781735149 "Fundamental Immunology", PMID:7880383] synonym: "negative extrathymic T lymphocyte selection" EXACT [] synonym: "negative extrathymic T-cell selection" EXACT [] synonym: "negative extrathymic T-lymphocyte selection" EXACT [] is_a: GO:0043383 ! negative T cell selection is_a: GO:0045062 ! extrathymic T cell selection [Term] id: GO:0045069 name: regulation of viral genome replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai] is_a: GO:0050792 ! regulation of viral reproduction is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0019079 ! viral genome replication [Term] id: GO:0045070 name: positive regulation of viral genome replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of viral genome replication." [GOC:ai] synonym: "activation of viral genome replication" NARROW [] synonym: "stimulation of viral genome replication" NARROW [] synonym: "up regulation of viral genome replication" EXACT [] synonym: "up-regulation of viral genome replication" EXACT [] synonym: "upregulation of viral genome replication" EXACT [] is_a: GO:0045069 ! regulation of viral genome replication is_a: GO:0048524 ! positive regulation of viral reproduction is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0019079 ! viral genome replication [Term] id: GO:0045071 name: negative regulation of viral genome replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators] synonym: "down regulation of viral genome replication" EXACT [] synonym: "down-regulation of viral genome replication" EXACT [] synonym: "downregulation of viral genome replication" EXACT [] synonym: "inhibition of viral genome replication" NARROW [] is_a: GO:0045069 ! regulation of viral genome replication is_a: GO:0048525 ! negative regulation of viral reproduction is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0019079 ! viral genome replication [Term] id: GO:0045072 name: regulation of interferon-gamma biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] synonym: "regulation of interferon-gamma anabolism" EXACT [] synonym: "regulation of interferon-gamma biosynthesis" EXACT [] synonym: "regulation of interferon-gamma formation" EXACT [] synonym: "regulation of interferon-gamma synthesis" EXACT [] is_a: GO:0032649 ! regulation of interferon-gamma production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042095 ! interferon-gamma biosynthetic process [Term] id: GO:0045073 name: regulation of chemokine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators] synonym: "regulation of chemokine anabolism" EXACT [] synonym: "regulation of chemokine biosynthesis" EXACT [] synonym: "regulation of chemokine formation" EXACT [] synonym: "regulation of chemokine synthesis" EXACT [] is_a: GO:0032642 ! regulation of chemokine production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042033 ! chemokine biosynthetic process [Term] id: GO:0045074 name: regulation of interleukin-10 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] synonym: "regulation of IL-10 biosynthesis" EXACT [] synonym: "regulation of IL-10 biosynthetic process" EXACT [] synonym: "regulation of interleukin-10 anabolism" EXACT [] synonym: "regulation of interleukin-10 biosynthesis" EXACT [] synonym: "regulation of interleukin-10 formation" EXACT [] synonym: "regulation of interleukin-10 synthesis" EXACT [] is_a: GO:0032653 ! regulation of interleukin-10 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042091 ! interleukin-10 biosynthetic process [Term] id: GO:0045075 name: regulation of interleukin-12 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] synonym: "regulation of IL-12 biosynthesis" EXACT [] synonym: "regulation of IL-12 biosynthetic process" EXACT [] synonym: "regulation of interleukin-12 anabolism" EXACT [] synonym: "regulation of interleukin-12 biosynthesis" EXACT [] synonym: "regulation of interleukin-12 formation" EXACT [] synonym: "regulation of interleukin-12 synthesis" EXACT [] is_a: GO:0032655 ! regulation of interleukin-12 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042090 ! interleukin-12 biosynthetic process [Term] id: GO:0045076 name: regulation of interleukin-2 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] synonym: "regulation of IL-2 biosynthesis" EXACT [] synonym: "regulation of IL-2 biosynthetic process" EXACT [] synonym: "regulation of interleukin-2 anabolism" EXACT [] synonym: "regulation of interleukin-2 biosynthesis" EXACT [] synonym: "regulation of interleukin-2 formation" EXACT [] synonym: "regulation of interleukin-2 synthesis" EXACT [] is_a: GO:0032663 ! regulation of interleukin-2 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042094 ! interleukin-2 biosynthetic process [Term] id: GO:0045077 name: negative regulation of interferon-gamma biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] synonym: "down regulation of interferon-gamma biosynthetic process" EXACT [] synonym: "down-regulation of interferon-gamma biosynthetic process" EXACT [] synonym: "downregulation of interferon-gamma biosynthetic process" EXACT [] synonym: "inhibition of interferon-gamma biosynthetic process" NARROW [] synonym: "negative regulation of interferon-gamma anabolism" EXACT [] synonym: "negative regulation of interferon-gamma biosynthesis" EXACT [] synonym: "negative regulation of interferon-gamma formation" EXACT [] synonym: "negative regulation of interferon-gamma synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process relationship: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process [Term] id: GO:0045078 name: positive regulation of interferon-gamma biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] synonym: "activation of interferon-gamma biosynthetic process" NARROW [] synonym: "positive regulation of interferon-gamma anabolism" EXACT [] synonym: "positive regulation of interferon-gamma biosynthesis" EXACT [] synonym: "positive regulation of interferon-gamma formation" EXACT [] synonym: "positive regulation of interferon-gamma synthesis" EXACT [] synonym: "stimulation of interferon-gamma biosynthetic process" NARROW [] synonym: "up regulation of interferon-gamma biosynthetic process" EXACT [] synonym: "up-regulation of interferon-gamma biosynthetic process" EXACT [] synonym: "upregulation of interferon-gamma biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process relationship: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process [Term] id: GO:0045079 name: negative regulation of chemokine biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators] synonym: "down regulation of chemokine biosynthetic process" EXACT [] synonym: "down-regulation of chemokine biosynthetic process" EXACT [] synonym: "downregulation of chemokine biosynthetic process" EXACT [] synonym: "inhibition of chemokine biosynthetic process" NARROW [] synonym: "negative regulation of chemokine anabolism" EXACT [] synonym: "negative regulation of chemokine biosynthesis" EXACT [] synonym: "negative regulation of chemokine formation" EXACT [] synonym: "negative regulation of chemokine synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045073 ! regulation of chemokine biosynthetic process relationship: negatively_regulates GO:0042033 ! chemokine biosynthetic process [Term] id: GO:0045080 name: positive regulation of chemokine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators] synonym: "activation of chemokine biosynthetic process" NARROW [] synonym: "positive regulation of chemokine anabolism" EXACT [] synonym: "positive regulation of chemokine biosynthesis" EXACT [] synonym: "positive regulation of chemokine formation" EXACT [] synonym: "positive regulation of chemokine synthesis" EXACT [] synonym: "stimulation of chemokine biosynthetic process" NARROW [] synonym: "up regulation of chemokine biosynthetic process" EXACT [] synonym: "up-regulation of chemokine biosynthetic process" EXACT [] synonym: "upregulation of chemokine biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045073 ! regulation of chemokine biosynthetic process relationship: positively_regulates GO:0042033 ! chemokine biosynthetic process [Term] id: GO:0045081 name: negative regulation of interleukin-10 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] synonym: "down regulation of interleukin-10 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-10 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-10 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-10 biosynthetic process" NARROW [] synonym: "negative regulation of IL-10 biosynthesis" EXACT [] synonym: "negative regulation of IL-10 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-10 anabolism" EXACT [] synonym: "negative regulation of interleukin-10 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-10 formation" EXACT [] synonym: "negative regulation of interleukin-10 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process relationship: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process [Term] id: GO:0045082 name: positive regulation of interleukin-10 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] synonym: "activation of interleukin-10 biosynthetic process" NARROW [] synonym: "positive regulation of IL-10 biosynthesis" EXACT [] synonym: "positive regulation of IL-10 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-10 anabolism" EXACT [] synonym: "positive regulation of interleukin-10 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-10 formation" EXACT [] synonym: "positive regulation of interleukin-10 synthesis" EXACT [] synonym: "stimulation of interleukin-10 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-10 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-10 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-10 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process relationship: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process [Term] id: GO:0045083 name: negative regulation of interleukin-12 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] synonym: "down regulation of interleukin-12 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-12 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-12 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-12 biosynthetic process" NARROW [] synonym: "negative regulation of IL-12 biosynthesis" EXACT [] synonym: "negative regulation of IL-12 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-12 anabolism" EXACT [] synonym: "negative regulation of interleukin-12 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-12 formation" EXACT [] synonym: "negative regulation of interleukin-12 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process relationship: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process [Term] id: GO:0045084 name: positive regulation of interleukin-12 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] synonym: "activation of interleukin-12 biosynthetic process" NARROW [] synonym: "positive regulation of IL-12 biosynthesis" EXACT [] synonym: "positive regulation of IL-12 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-12 anabolism" EXACT [] synonym: "positive regulation of interleukin-12 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-12 formation" EXACT [] synonym: "positive regulation of interleukin-12 synthesis" EXACT [] synonym: "stimulation of interleukin-12 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-12 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-12 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-12 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process relationship: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process [Term] id: GO:0045085 name: negative regulation of interleukin-2 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] synonym: "down regulation of interleukin-2 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-2 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-2 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-2 biosynthetic process" NARROW [] synonym: "negative regulation of IL-2 biosynthesis" EXACT [] synonym: "negative regulation of IL-2 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-2 anabolism" EXACT [] synonym: "negative regulation of interleukin-2 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-2 formation" EXACT [] synonym: "negative regulation of interleukin-2 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process relationship: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process [Term] id: GO:0045086 name: positive regulation of interleukin-2 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] synonym: "activation of interleukin-2 biosynthetic process" NARROW [] synonym: "positive regulation of IL-2 biosynthesis" EXACT [] synonym: "positive regulation of IL-2 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-2 anabolism" EXACT [] synonym: "positive regulation of interleukin-2 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-2 formation" EXACT [] synonym: "positive regulation of interleukin-2 synthesis" EXACT [] synonym: "stimulation of interleukin-2 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-2 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-2 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-2 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process relationship: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process [Term] id: GO:0045087 name: innate immune response namespace: biological_process alt_id: GO:0002226 def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "nonspecific immune response" EXACT [] xref: Reactome:1253146 "Innate Immunity Signaling" xref: Reactome:1280080 "Innate Immunity Signaling" xref: Reactome:1298961 "Innate Immunity Signaling" xref: Reactome:1326651 "Innate Immunity Signaling" xref: Reactome:1352763 "Innate Immunity Signaling" xref: Reactome:1372974 "Innate Immunity Signaling" xref: Reactome:1392990 "Innate Immunity Signaling" xref: Reactome:1417470 "Innate Immunity Signaling" xref: Reactome:1450563 "Innate Immunity Signaling" xref: Reactome:1471069 "Innate Immunity Signaling" xref: Reactome:1483085 "Innate Immunity Signaling" xref: Reactome:1496960 "Innate Immunity Signaling" xref: Reactome:1514347 "Innate Immunity Signaling" xref: Reactome:1521220 "Innate Immunity Signaling" xref: Reactome:1526808 "Innate Immunity Signaling" xref: Reactome:1532534 "Innate Immunity Signaling" xref: Reactome:168249 "Innate Immunity Signaling" xref: Wikipedia:Innate_immune_system is_a: GO:0006952 ! defense response is_a: GO:0006955 ! immune response [Term] id: GO:0045088 name: regulation of innate immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] is_a: GO:0031347 ! regulation of defense response is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0045087 ! innate immune response [Term] id: GO:0045089 name: positive regulation of innate immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] synonym: "stimulation of innate immune response" NARROW [] synonym: "up regulation of innate immune response" EXACT [] synonym: "up-regulation of innate immune response" EXACT [] synonym: "upregulation of innate immune response" EXACT [] is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0045087 ! innate immune response [Term] id: GO:0045090 name: retroviral genome replication namespace: biological_process def: "Any process involved in the replication of a retroviral genome. Retroviruses use RNA as their nucleic acid and reverse transcriptase to copy their genome into the DNA of the host cells chromosomes." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0019079 ! viral genome replication [Term] id: GO:0045091 name: regulation of retroviral genome replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retroviral genome replication." [GOC:go_curators] is_a: GO:0045069 ! regulation of viral genome replication relationship: regulates GO:0045090 ! retroviral genome replication [Term] id: GO:0045092 name: interleukin-18 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435] synonym: "IL-18 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0045093 name: interleukin-18 alpha subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with the alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells." [PMID:10653850] synonym: "IL-18Ra binding" EXACT [] is_a: GO:0042007 ! interleukin-18 binding [Term] id: GO:0045094 name: interleukin-18 beta subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with the beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a." [PMID:10653850] synonym: "IL-18Rb binding" EXACT [] is_a: GO:0042007 ! interleukin-18 binding [Term] id: GO:0045095 name: keratin filament namespace: cellular_component def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363] synonym: "acidic keratin" RELATED [] synonym: "basic/neutral keratin" RELATED [] is_a: GO:0005882 ! intermediate filament [Term] id: GO:0045096 name: acidic keratin namespace: cellular_component def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194] comment: This term was made obsolete because it represents a gene product. synonym: "type I intermediate filament" EXACT [] is_obsolete: true replaced_by: GO:0045095 [Term] id: GO:0045097 name: basic/neutral keratin namespace: cellular_component def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194] comment: This term was made obsolete because it represents a gene product. synonym: "type II intermediate filament" EXACT [] is_obsolete: true replaced_by: GO:0045095 [Term] id: GO:0045098 name: type III intermediate filament namespace: cellular_component def: "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363] synonym: "desmin" NARROW [] synonym: "glial fibrillary acidic protein" NARROW [] synonym: "peripherin" NARROW [] synonym: "type III intermediate filament associated protein" NARROW [] synonym: "vimentin" NARROW [] is_a: GO:0005882 ! intermediate filament [Term] id: GO:0045099 name: vimentin namespace: cellular_component def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045098 [Term] id: GO:0045100 name: desmin namespace: cellular_component def: "OBSOLETE. A type of intermediate filament." [ISBN:0815316194] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0045098 [Term] id: GO:0045101 name: glial fibrillary acidic protein namespace: cellular_component def: "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes." [ISBN:0716731363] comment: This term was made obsolete because it represents a gene product. synonym: "GFAP" EXACT [] is_obsolete: true consider: GO:0045098 [Term] id: GO:0045102 name: peripherin namespace: cellular_component def: "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system." [ISBN:0716731363] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0045098 [Term] id: GO:0045103 name: intermediate filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai] is_a: GO:0009987 ! cellular process [Term] id: GO:0045104 name: intermediate filament cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai] synonym: "intermediate filament cytoskeleton organisation" EXACT [GOC:curators] synonym: "intermediate filament cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0045103 ! intermediate filament-based process [Term] id: GO:0045105 name: intermediate filament polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament." [GOC:ai] is_a: GO:0034621 ! cellular macromolecular complex subunit organization relationship: part_of GO:0045104 ! intermediate filament cytoskeleton organization [Term] id: GO:0045106 name: intermediate filament depolymerization namespace: biological_process def: "Disassembly of intermediate filaments by the removal of component monomers from a filament." [GOC:mah, ISBN:0716731363] is_a: GO:0045105 ! intermediate filament polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization [Term] id: GO:0045107 name: intermediate filament polymerization namespace: biological_process def: "Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain." [GOC:mah, PMID:8776884] is_a: GO:0045105 ! intermediate filament polymerization or depolymerization is_a: GO:0051258 ! protein polymerization [Term] id: GO:0045108 name: regulation of intermediate filament polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases." [ISBN:0716731363] is_a: GO:0051493 ! regulation of cytoskeleton organization relationship: regulates GO:0045105 ! intermediate filament polymerization or depolymerization [Term] id: GO:0045109 name: intermediate filament organization namespace: biological_process def: "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai] synonym: "intermediate filament organisation" EXACT [GOC:curators] is_a: GO:0045104 ! intermediate filament cytoskeleton organization [Term] id: GO:0045110 name: intermediate filament bundle assembly namespace: biological_process def: "The formation of the bundles of intermediate filaments, known as tonofilaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs." [ISBN:0716731363] synonym: "tonofilament assembly" NARROW [] is_a: GO:0045109 ! intermediate filament organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0045111 name: intermediate filament cytoskeleton namespace: cellular_component def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0045112 name: integrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "integrin anabolism" EXACT [] synonym: "integrin biosynthesis" EXACT [] synonym: "integrin formation" EXACT [] synonym: "integrin synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0007009 ! plasma membrane organization [Term] id: GO:0045113 name: regulation of integrin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] synonym: "regulation of integrin anabolism" EXACT [] synonym: "regulation of integrin biosynthesis" EXACT [] synonym: "regulation of integrin formation" EXACT [] synonym: "regulation of integrin synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0045112 ! integrin biosynthetic process [Term] id: GO:0045114 name: beta 2 integrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit." [GOC:go_curators] synonym: "beta 2 integrin anabolism" EXACT [] synonym: "beta 2 integrin biosynthesis" EXACT [] synonym: "beta 2 integrin formation" EXACT [] synonym: "beta 2 integrin synthesis" EXACT [] is_a: GO:0045112 ! integrin biosynthetic process [Term] id: GO:0045115 name: regulation of beta 2 integrin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] synonym: "regulation of beta 2 integrin anabolism" EXACT [] synonym: "regulation of beta 2 integrin biosynthesis" EXACT [] synonym: "regulation of beta 2 integrin formation" EXACT [] synonym: "regulation of beta 2 integrin synthesis" EXACT [] is_a: GO:0045113 ! regulation of integrin biosynthetic process relationship: regulates GO:0045114 ! beta 2 integrin biosynthetic process [Term] id: GO:0045116 name: protein neddylation namespace: biological_process alt_id: GO:0019943 def: "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580] comment: Note that currently, the only known substrates of neddylation are cullin family proteins. synonym: "RUB1-protein conjugation" EXACT [] is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0045117 name: azole transport namespace: biological_process def: "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] is_a: GO:0015893 ! drug transport [Term] id: GO:0045118 name: azole transporter activity namespace: molecular_function def: "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of or within a cell, or between cells." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0045119 name: azole:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances." [GOC:ai, ISBN:3527307206, Wikipedia:Azole] synonym: "azole:proton antiporter activity" EXACT [GOC:mah] synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW [] is_a: GO:0015307 ! drug:hydrogen antiporter activity is_a: GO:0045118 ! azole transporter activity [Term] id: GO:0045120 name: pronucleus namespace: cellular_component def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Pronucleus is_a: GO:0005634 ! nucleus [Term] id: GO:0045121 name: membrane raft namespace: cellular_component def: "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198] synonym: "GEM domain" RELATED [] synonym: "glycolipid-enriched membrane domain" RELATED [] synonym: "lipid raft" EXACT [] xref: Wikipedia:Lipid_raft is_a: GO:0044425 ! membrane part [Term] id: GO:0045122 name: aflatoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [ISBN:0716731363, ISBN:0815316194] subset: gosubset_prok synonym: "aflatoxin anabolism" EXACT [] synonym: "aflatoxin biosynthesis" EXACT [] synonym: "aflatoxin formation" EXACT [] synonym: "aflatoxin synthesis" EXACT [] is_a: GO:0009805 ! coumarin biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0046222 ! aflatoxin metabolic process [Term] id: GO:0045123 name: cellular extravasation namespace: biological_process def: "The migration of a leukocyte from the blood vessels into the surrounding tissue." [GOC:jl] synonym: "immune cell cellular extravasation" EXACT [] synonym: "leucocyte cellular extravasation" EXACT [] synonym: "leukocyte cellular extravasation" EXACT [] synonym: "transendothelial leukocyte migration" EXACT [GOC:rl] xref: Wikipedia:Leukocyte_extravasation is_a: GO:0050900 ! leukocyte migration [Term] id: GO:0045124 name: regulation of bone resorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0046850 ! regulation of bone remodeling relationship: regulates GO:0045453 ! bone resorption [Term] id: GO:0045125 name: bioactive lipid receptor activity namespace: molecular_function def: "Combining with a bioactive lipid to initiate a change in cell activity. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes." [GOC:mah, PMID:12215548, PMID:18216770] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0045127 name: N-acetylglucosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.59, RHEA:17420] subset: gosubset_prok synonym: "2-acetylamino-2-deoxy-D-glucose kinase activity" EXACT [EC:2.7.1.59] synonym: "acetylaminodeoxyglucokinase activity" EXACT [EC:2.7.1.59] synonym: "acetylglucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.59] synonym: "ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.59] synonym: "ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.59] synonym: "GlcNAc kinase activity" EXACT [EC:2.7.1.59] xref: EC:2.7.1.59 xref: KEGG:R01201 xref: MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN xref: RHEA:17420 is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0045128 name: negative regulation of reciprocal meiotic recombination namespace: biological_process def: "Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of meiotic recombination" EXACT [] synonym: "down-regulation of meiotic recombination" EXACT [] synonym: "downregulation of meiotic recombination" EXACT [] synonym: "inhibition of meiotic recombination" NARROW [] synonym: "suppression of meiotic recombination" EXACT [] is_a: GO:0010520 ! regulation of reciprocal meiotic recombination is_a: GO:0045835 ! negative regulation of meiosis is_a: GO:0045910 ! negative regulation of DNA recombination relationship: negatively_regulates GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0045129 name: NAD-independent histone deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, EC:3.5.1.98, RHEA:24551] synonym: "AcuC" RELATED [] is_a: GO:0004407 ! histone deacetylase activity [Term] id: GO:0045130 name: keratan sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate." [EC:2.8.2.21] synonym: "3'-phosphoadenylyl keratan sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "3'-phosphoadenylylsulfate:keratan sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "keratan sulfate Gal-6-sulfotransferase activity" EXACT [] synonym: "keratan sulfate sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "keratan sulphotransferase activity" EXACT [] xref: EC:2.8.2.21 xref: MetaCyc:KERATAN-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0045131 name: pre-mRNA branch point binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pre-mRNA branch point sequence, located upstream of the 3' splice site." [PMID:11691992, PMID:9722632] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0045132 name: meiotic chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] is_a: GO:0007059 ! chromosome segregation relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0045133 name: 2,3-dihydroxybenzoate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.14, RHEA:18480] synonym: "2,3-dihydroxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoate oxygenase activity" EXACT [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoic oxygenase activity" EXACT [EC:1.13.11.14] synonym: "o-pyrocatechuate oxygenase activity" EXACT [EC:1.13.11.14] xref: EC:1.13.11.14 xref: KEGG:R01507 xref: MetaCyc:1.13.11.14-RXN xref: RHEA:18480 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0045134 name: uridine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6] synonym: "UDPase activity" EXACT [EC:3.6.1.6] synonym: "uridine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "uridine diphosphatase activity" EXACT [EC:3.6.1.6] is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0045135 name: poly(beta-D-mannuronate) lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [EC:4.2.2.3] subset: gosubset_prok synonym: "alginase activity" EXACT [EC:4.2.2.3] synonym: "alginase I" RELATED [EC:4.2.2.3] synonym: "alginate lyase activity" EXACT [EC:4.2.2.3] synonym: "alginate lyase I activity" NARROW [EC:4.2.2.3] synonym: "poly(beta-D-1,4-mannuronide) lyase activity" EXACT [EC:4.2.2.3] synonym: "poly(mana) alginate lyase activity" NARROW [EC:4.2.2.3] xref: EC:4.2.2.3 xref: MetaCyc:4.2.2.3-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0045136 name: development of secondary sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007275 ! multicellular organismal development relationship: part_of GO:0007548 ! sex differentiation [Term] id: GO:0045137 name: development of primary sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007275 ! multicellular organismal development relationship: part_of GO:0007548 ! sex differentiation [Term] id: GO:0045138 name: tail tip morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tail tip are generated and organized. The tail tip undergoes morphogenesis to form a copulatory structure. The most posterior hypodermal cells in the tail define a specialized, sexually dimorphic compartment in which cells fuse and retract in the male, changing their shape from a tapered cone to a blunt dome. An example of this process is found in Caenorhabditis elegans." [PMID:10049567] synonym: "male tail morphogenesis" BROAD [] is_a: GO:0035121 ! tail morphogenesis [Term] id: GO:0045139 name: copper sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046688 [Term] id: GO:0045140 name: inositol phosphoceramide synthase activity namespace: molecular_function def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [MetaCyc:RXN3O-581, PMID:9405490, PMID:9614099] synonym: "IPC synthase activity" EXACT [] xref: EC:2.4.1.- xref: MetaCyc:RXN3O-581 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0045141 name: meiotic telomere clustering namespace: biological_process def: "The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in homologous chromosome pairing and therefore progression through meiosis." [GOC:vw, PMID:10690419] synonym: "bouquet biosynthesis" NARROW [] synonym: "bouquet formation" NARROW [] is_a: GO:0034397 ! telomere localization is_a: GO:0070192 ! chromosome organization involved in meiosis [Term] id: GO:0045142 name: triplex DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [PMID:10681538] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0045143 name: homologous chromosome segregation namespace: biological_process alt_id: GO:0007061 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194] synonym: "meiosis I, chromosome segregation" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0045144 name: meiotic sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194] synonym: "meiosis II, chromosome segregation" EXACT [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:0045132 ! meiotic chromosome segregation is_a: GO:0070192 ! chromosome organization involved in meiosis relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0045145 name: single-stranded DNA specific 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101] synonym: "ssDNA-specific 5'-3' exodeoxyribonuclease activity" EXACT [GOC:mah] is_a: GO:0008297 ! single-stranded DNA specific exodeoxyribonuclease activity is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity [Term] id: GO:0045146 name: initiation of acetate catabolic process by acetate namespace: biological_process def: "The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [PMID:11741859] subset: gosubset_prok synonym: "initiation of acetate breakdown by acetate" EXACT [] synonym: "initiation of acetate degradation by acetate" EXACT [] is_a: GO:0010034 ! response to acetate is_a: GO:0043077 ! initiation of acetate catabolic process [Term] id: GO:0045147 name: regulation of initiation of acetate catabolic process by acetate namespace: biological_process def: "Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of initiation of acetate breakdown by acetate" EXACT [] synonym: "regulation of initiation of acetate degradation by acetate" EXACT [] is_a: GO:0045734 ! regulation of acetate catabolic process is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0045146 ! initiation of acetate catabolic process by acetate [Term] id: GO:0045148 name: tripeptide aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of the N-terminal residue from a tripeptide." [EC:3.4.11.4] subset: gosubset_prok synonym: "alanine-phenylalanine-proline arylamidase activity" EXACT [EC:3.4.11.4] synonym: "aminoexotripeptidase activity" EXACT [EC:3.4.11.4] synonym: "aminotripeptidase activity" EXACT [] synonym: "imidoendopeptidase activity" EXACT [EC:3.4.11.4] synonym: "lymphopeptidase activity" EXACT [EC:3.4.11.4] synonym: "peptidase B" RELATED [EC:3.4.11.4] synonym: "peptidase T" EXACT [] xref: EC:3.4.11.4 xref: MetaCyc:3.4.11.4-RXN is_a: GO:0004177 ! aminopeptidase activity is_a: GO:0034701 ! tripeptidase activity [Term] id: GO:0045149 name: acetoin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source." [GOC:mlg] subset: gosubset_prok synonym: "acetoin metabolism" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0045150 name: acetoin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone." [GOC:mlg] subset: gosubset_prok synonym: "acetoin breakdown" EXACT [] synonym: "acetoin catabolism" EXACT [] synonym: "acetoin degradation" EXACT [] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0045149 ! acetoin metabolic process [Term] id: GO:0045151 name: acetoin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone." [GOC:mlg] subset: gosubset_prok synonym: "acetoin anabolism" EXACT [] synonym: "acetoin biosynthesis" EXACT [] synonym: "acetoin formation" EXACT [] synonym: "acetoin synthesis" EXACT [] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0045149 ! acetoin metabolic process [Term] id: GO:0045152 name: antisigma factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator." [GOC:mlg] subset: gosubset_prok synonym: "antisigma factor antagonist activity" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0045153 name: electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity namespace: molecular_function def: "Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] synonym: "cytochrome b562" NARROW [] synonym: "cytochrome b566" NARROW [] synonym: "cytochrome c1" NARROW [] synonym: "soluble cytochrome b562" RELATED [] xref: Reactome:19911 "electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity" is_a: GO:0009055 ! electron carrier activity [Term] id: GO:0045154 name: electron transporter, transferring electrons within cytochrome c oxidase complex activity namespace: molecular_function def: "Enables the directed movement of electrons within the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] synonym: "cytochrome a" NARROW [] synonym: "cytochrome a3/copper complex" NARROW [] is_a: GO:0009055 ! electron carrier activity [Term] id: GO:0045155 name: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity namespace: molecular_function def: "Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363] subset: gosubset_prok synonym: "cytochrome" RELATED [] synonym: "cytochrome c" NARROW [] is_a: GO:0009055 ! electron carrier activity [Term] id: GO:0045156 name: electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity namespace: molecular_function def: "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] subset: gosubset_prok synonym: "cytochrome" RELATED [] synonym: "cytochrome bc1 complex" NARROW [] is_a: GO:0009055 ! electron carrier activity [Term] id: GO:0045157 name: electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity namespace: molecular_function def: "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] is_a: GO:0009055 ! electron carrier activity [Term] id: GO:0045158 name: electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity namespace: molecular_function def: "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] subset: gosubset_prok synonym: "cytochrome" RELATED [] synonym: "cytochrome b/b6" RELATED [] synonym: "cytochrome b6" NARROW [] synonym: "cytochrome f" NARROW [] is_a: GO:0009055 ! electron carrier activity [Term] id: GO:0045159 name: myosin II binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0045160 name: myosin I complex namespace: cellular_component def: "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0045161 name: neuronal ion channel clustering namespace: biological_process def: "The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0042551 ! neuron maturation [Term] id: GO:0045162 name: clustering of voltage-gated sodium channels namespace: biological_process def: "The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization." [PMID:11456440] synonym: "clustering of voltage gated sodium channels" EXACT [] synonym: "clustering of voltage-dependent sodium channels" EXACT [] synonym: "Nav channel clustering" EXACT [] synonym: "voltage-gated sodium channel clustering" EXACT [] is_a: GO:0045161 ! neuronal ion channel clustering [Term] id: GO:0045163 name: clustering of voltage-gated potassium channels namespace: biological_process def: "The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode." [PMID:11456440] synonym: "clustering of voltage gated potassium channels" EXACT [] synonym: "clustering of voltage-dependent potassium channels" EXACT [] synonym: "Kv channel clustering" EXACT [] synonym: "voltage-gated potassium channel clustering" EXACT [] is_a: GO:0045161 ! neuronal ion channel clustering [Term] id: GO:0045164 name: secretin (sensu Mammalia) namespace: molecular_function def: "OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract." [PMID:11320551] comment: This term was made obsolete because it represents a gene product rather than a molecular function. is_obsolete: true consider: GO:0046659 [Term] id: GO:0045165 name: cell fate commitment namespace: biological_process def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0030154 ! cell differentiation [Term] id: GO:0045167 name: asymmetric protein localization involved in cell fate determination namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai] synonym: "asymmetric protein localisation involved in cell fate determination" EXACT [GOC:mah] synonym: "asymmetric protein localization involved in cell fate commitment" EXACT [] synonym: "asymmetric protein localization resulting in cell fate commitment" EXACT [] synonym: "cell fate commitment, asymmetric protein localization" EXACT [] is_a: GO:0008105 ! asymmetric protein localization relationship: part_of GO:0001709 ! cell fate determination [Term] id: GO:0045168 name: cell-cell signaling involved in cell fate commitment namespace: biological_process def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "cell fate commitment, cell-cell signaling" EXACT [] synonym: "cell fate commitment, cell-cell signalling" EXACT [] synonym: "cell-cell signaling involved in cell fate commitment" EXACT [] synonym: "cell-cell signaling resulting in cell fate commitment" EXACT [] synonym: "cell-cell signalling during cell fate commitment" EXACT [] synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb] synonym: "cell-cell signalling resulting in cell fate commitment" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0045169 name: fusome namespace: cellular_component def: "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0045170 name: spectrosome namespace: cellular_component def: "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0045171 name: intercellular bridge namespace: cellular_component def: "A direct link between the cytoplasms of sister cells that allows cells to communicate with one another. Germline intercellular bridges facilitate the passage of cytoplasmic components between cells during development. Intercellular bridges have also been found connecting somatic cells." [PMID:9635420] is_a: GO:0044421 ! extracellular region part [Term] id: GO:0045172 name: germline ring canal namespace: cellular_component def: "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] is_a: GO:0045171 ! intercellular bridge [Term] id: GO:0045173 name: O-sialoglycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities." [GOC:go_curators, PMID:8824323] subset: gosubset_prok synonym: "O-sialoglycoprotein breakdown" EXACT [] synonym: "O-sialoglycoprotein catabolism" EXACT [] synonym: "O-sialoglycoprotein degradation" EXACT [] is_a: GO:0006516 ! glycoprotein catabolic process [Term] id: GO:0045174 name: glutathione dehydrogenase (ascorbate) activity namespace: molecular_function def: "Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [EC:1.8.5.1, RHEA:24427] synonym: "dehydroascorbate reductase activity" EXACT [] synonym: "dehydroascorbic acid reductase activity" EXACT [EC:1.8.5.1] synonym: "dehydroascorbic reductase activity" EXACT [EC:1.8.5.1] synonym: "DHA reductase activity" EXACT [EC:1.8.5.1] synonym: "GDOR" RELATED [EC:1.8.5.1] synonym: "glutathione dehydroascorbate reductase activity" EXACT [EC:1.8.5.1] synonym: "glutathione:dehydroascorbate oxidoreductase activity" EXACT [EC:1.8.5.1] synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" EXACT [EC:1.8.5.1] xref: EC:1.8.5.1 xref: KEGG:R01108 xref: MetaCyc:1.8.5.1-RXN xref: Reactome:20045 "glutathione dehydrogenase (ascorbate) activity" xref: RHEA:24427 is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [Term] id: GO:0045175 name: basal protein localization namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf] synonym: "basal protein localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of basal protein localization" EXACT [] synonym: "establishment and maintenance of protein localization in basal part of cell" EXACT [] is_a: GO:0008105 ! asymmetric protein localization [Term] id: GO:0045176 name: apical protein localization namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf] synonym: "apical protein localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of apical protein localization" EXACT [] synonym: "establishment and maintenance of protein localization in apical part of cell" EXACT [] is_a: GO:0008105 ! asymmetric protein localization [Term] id: GO:0045177 name: apical part of cell namespace: cellular_component def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] subset: goslim_pir is_a: GO:0044464 ! cell part [Term] id: GO:0045178 name: basal part of cell namespace: cellular_component def: "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194] subset: goslim_pir is_a: GO:0044464 ! cell part [Term] id: GO:0045179 name: apical cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0045177 ! apical part of cell [Term] id: GO:0045180 name: basal cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf] is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0045178 ! basal part of cell [Term] id: GO:0045181 name: glutamate synthase activity, NADH or NADPH as acceptor namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." [EC:1.4.1.13, EC:1.4.1.14] subset: gosubset_prok xref: EC:1.4.1.- is_a: GO:0015930 ! glutamate synthase activity is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0045182 name: translation regulator activity namespace: molecular_function def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] subset: goslim_candida subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "translation factor activity" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0045183 name: translation factor activity, non-nucleic acid binding namespace: molecular_function def: "A translation regulator activity that does not involve binding to nucleic acids." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:0045182 ! translation regulator activity [Term] id: GO:0045184 name: establishment of protein localization namespace: biological_process def: "The directed movement of a protein to a specific location." [GOC:bf] subset: gosubset_prok synonym: "establishment of protein localisation" EXACT [GOC:mah] synonym: "protein positioning" EXACT [] synonym: "protein recruitment" EXACT [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0008104 ! protein localization [Term] id: GO:0045185 name: maintenance of protein location namespace: biological_process def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] subset: gosubset_prok synonym: "active protein retrieval" NARROW [] synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb] synonym: "protein retention" NARROW [] synonym: "protein sequestering" NARROW [] is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0008104 ! protein localization [Term] id: GO:0045186 name: zonula adherens assembly namespace: biological_process def: "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] is_a: GO:0007043 ! cell-cell junction assembly relationship: part_of GO:0043297 ! apical junction assembly [Term] id: GO:0045187 name: regulation of circadian sleep/wake cycle, sleep namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] synonym: "regulation of sleep" EXACT [] is_a: GO:0042749 ! regulation of circadian sleep/wake cycle relationship: regulates GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0045188 name: regulation of circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators] synonym: "regulation of non-REM sleep" EXACT [] is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0045189 name: connective tissue growth factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [http://www.copewithcytokines.de] synonym: "connective tissue growth factor anabolism" EXACT [] synonym: "connective tissue growth factor biosynthesis" EXACT [] synonym: "connective tissue growth factor formation" EXACT [] synonym: "connective tissue growth factor synthesis" EXACT [] synonym: "CTGF biosynthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032601 ! connective tissue growth factor production [Term] id: GO:0045190 name: isotype switching namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'. synonym: "class switch recombination" EXACT [] synonym: "class switching" EXACT [] synonym: "isotype switch recombination" EXACT [] xref: Wikipedia:Immunoglobulin_class_switching is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response is_a: GO:0002312 ! B cell activation involved in immune response [Term] id: GO:0045191 name: regulation of isotype switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching." [GOC:ai] synonym: "regulation of class switch recombination" EXACT [] synonym: "regulation of class switching" EXACT [] synonym: "regulation of isotype switch recombination" EXACT [] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0050864 ! regulation of B cell activation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0045190 ! isotype switching [Term] id: GO:0045192 name: low-density lipoprotein catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. synonym: "LDL catabolic process" EXACT [] synonym: "LDL catabolism" EXACT [] synonym: "low-density lipoprotein breakdown" EXACT [] synonym: "low-density lipoprotein catabolism" EXACT [] synonym: "low-density lipoprotein degradation" EXACT [] is_obsolete: true [Term] id: GO:0045193 name: acetylated low-density lipoprotein catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins." [GOC:go_curators] comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. synonym: "Ac-LDL catabolic process" EXACT [] synonym: "Ac-LDL catabolism" EXACT [] synonym: "acetylated low-density lipoprotein breakdown" EXACT [] synonym: "acetylated low-density lipoprotein catabolism" EXACT [] synonym: "acetylated low-density lipoprotein degradation" EXACT [] is_obsolete: true [Term] id: GO:0045194 name: oxidized low-density lipoprotein catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins." [GOC:go_curators] comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. synonym: "Ox-LDL catabolic process" EXACT [] synonym: "Ox-LDL catabolism" EXACT [] synonym: "oxidized low-density lipoprotein breakdown" EXACT [] synonym: "oxidized low-density lipoprotein catabolism" EXACT [] synonym: "oxidized low-density lipoprotein degradation" EXACT [] is_obsolete: true [Term] id: GO:0045195 name: gallstone formation namespace: biological_process def: "OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile." [http://www.ddc.musc.edu/ddc_pro/pro_development/basic_science/gallstones.htm] comment: This term was made obsolete because the process it represents is pathological. is_obsolete: true [Term] id: GO:0045196 name: establishment or maintenance of neuroblast polarity namespace: biological_process alt_id: GO:0043339 alt_id: GO:0043342 def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu] synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0045197 name: establishment or maintenance of epithelial cell apical/basal polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity [Term] id: GO:0045198 name: establishment of epithelial cell apical/basal polarity namespace: biological_process def: "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] is_a: GO:0030859 ! polarized epithelial cell differentiation is_a: GO:0035089 ! establishment of apical/basal cell polarity is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity is_a: GO:0090162 ! establishment of epithelial cell polarity [Term] id: GO:0045199 name: maintenance of epithelial cell apical/basal polarity namespace: biological_process def: "The maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf] is_a: GO:0035090 ! maintenance of apical/basal cell polarity is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity [Term] id: GO:0045200 name: establishment of neuroblast polarity namespace: biological_process alt_id: GO:0043340 alt_id: GO:0043343 def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] synonym: "establishment of neuroblast cell polarity" EXACT [] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity [Term] id: GO:0045201 name: maintenance of neuroblast polarity namespace: biological_process alt_id: GO:0043341 alt_id: GO:0043344 def: "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] synonym: "maintenance of neuroblast cell polarity" EXACT [] is_a: GO:0030011 ! maintenance of cell polarity is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity [Term] id: GO:0045202 name: synapse namespace: cellular_component def: "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir synonym: "synaptic junction" EXACT [] xref: NIF_Subcellular:sao914572699 xref: Wikipedia:Chemical_synapse is_a: GO:0005575 ! cellular_component [Term] id: GO:0045203 name: integral to cell outer membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the external outer membrane of the cell. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators, GOC:mtg_sensu] subset: gosubset_prok synonym: "integral to external membrane" RELATED [] synonym: "integral to outer membrane" RELATED [] is_a: GO:0016021 ! integral to membrane is_a: GO:0031230 ! intrinsic to cell outer membrane [Term] id: GO:0045204 name: MAPK export from nucleus namespace: biological_process def: "The directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:ebc] synonym: "cytoplasmic translocation of MAP kinase" EXACT [] synonym: "cytoplasmic translocation of mitogen-activated protein kinase" EXACT [] synonym: "MAPK export from cell nucleus" EXACT [] synonym: "MAPK export out of nucleus" EXACT [] synonym: "MAPK transport from nucleus to cytoplasm" EXACT [] synonym: "MAPK-nucleus export" EXACT [] is_a: GO:0006611 ! protein export from nucleus [Term] id: GO:0045205 name: MAPK transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of MAP kinase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because we do not know what it was intended to represent when it was created. is_obsolete: true [Term] id: GO:0045206 name: MAPK phosphatase transporter activity namespace: molecular_function alt_id: GO:0045207 def: "OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because we do not know what it was intended to represent when it was created. synonym: "leptomycin B-sensitive MAPK phosphatase transporter activity" NARROW [] synonym: "leptomycin B-sensitive MKP shuttle" NARROW [] synonym: "MKP shuttle" NARROW [] is_obsolete: true [Term] id: GO:0045208 name: MAPK phosphatase export from nucleus namespace: biological_process def: "The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc] synonym: "MAPK phosphatase export from cell nucleus" EXACT [] synonym: "MAPK phosphatase export out of nucleus" EXACT [] synonym: "MAPK phosphatase transport from nucleus to cytoplasm" EXACT [] synonym: "MAPK phosphatase-nucleus export" EXACT [] is_a: GO:0006611 ! protein export from nucleus [Term] id: GO:0045209 name: MAPK phosphatase export from nucleus, leptomycin B sensitive namespace: biological_process def: "Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc] synonym: "leptomycin B-sensitive MAPK phosphatase export out of nucleus" EXACT [] synonym: "leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm" EXACT [] synonym: "leptomycin B-sensitive MAPK phosphatase-nucleus export" EXACT [] synonym: "MAPK phosphatase export from cell nucleus, leptomycin B sensitive" EXACT [] synonym: "MAPK phosphatase export out of nucleus, leptomycin B sensitive" EXACT [] synonym: "MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive" EXACT [] synonym: "MAPK phosphatase-nucleus export, leptomycin B sensitive" EXACT [] is_a: GO:0045208 ! MAPK phosphatase export from nucleus [Term] id: GO:0045210 name: FasL biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines." [http://www.copewithcytokines.de/] synonym: "APT1LG1 biosynthetic process" EXACT [GOC:add] synonym: "CD178 biosynthetic process" EXACT [GOC:add] synonym: "CD95L biosynthesis" EXACT [GOC:add] synonym: "CD95L biosynthetic process" EXACT [GOC:add] synonym: "fas ligand biosynthetic process" EXACT [GOC:add, PRO:000000095] synonym: "Fas-L biosynthetic process" EXACT [GOC:add] synonym: "FasL anabolism" EXACT [] synonym: "FasL biosynthesis" EXACT [] synonym: "FasL formation" EXACT [] synonym: "FasL synthesis" EXACT [] synonym: "FASLG biosynthetic process" EXACT [GOC:add] is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0045211 name: postsynaptic membrane namespace: cellular_component def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "post-synaptic membrane" EXACT [] is_a: GO:0097060 ! synaptic membrane [Term] id: GO:0045212 name: neurotransmitter receptor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of neurotransmitter receptors." [GOC:ai] synonym: "neurotransmitter receptor anabolism" EXACT [] synonym: "neurotransmitter receptor biosynthesis" EXACT [] synonym: "neurotransmitter receptor formation" EXACT [] synonym: "neurotransmitter receptor synthesis" EXACT [] is_a: GO:0032800 ! receptor biosynthetic process is_a: GO:0045213 ! neurotransmitter receptor metabolic process [Term] id: GO:0045213 name: neurotransmitter receptor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators] synonym: "neurotransmitter receptor metabolism" EXACT [] is_a: GO:0043112 ! receptor metabolic process relationship: part_of GO:0007268 ! synaptic transmission [Term] id: GO:0045214 name: sarcomere organization namespace: biological_process alt_id: GO:0006938 def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] synonym: "sarcomere alignment" EXACT [] synonym: "sarcomere organisation" EXACT [GOC:curators] is_a: GO:0031032 ! actomyosin structure organization relationship: part_of GO:0030239 ! myofibril assembly [Term] id: GO:0045216 name: cell-cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "cell-cell junction assembly and maintenance" EXACT [] synonym: "cell-cell junction biogenesis" RELATED [] synonym: "intercellular junction assembly and maintenance" EXACT [] xref: Reactome:1253731 "Cell-cell junction organization" xref: Reactome:1280662 "Cell-cell junction organization" xref: Reactome:1299487 "Cell-cell junction organization" xref: Reactome:1327248 "Cell-cell junction organization" xref: Reactome:1353343 "Cell-cell junction organization" xref: Reactome:1373516 "Cell-cell junction organization" xref: Reactome:1393538 "Cell-cell junction organization" xref: Reactome:1418038 "Cell-cell junction organization" xref: Reactome:1451128 "Cell-cell junction organization" xref: Reactome:421270 "Cell-cell junction organization" is_a: GO:0034330 ! cell junction organization [Term] id: GO:0045217 name: cell-cell junction maintenance namespace: biological_process def: "The maintenance of junctions between cells." [GOC:ai] synonym: "intercellular junction maintenance" EXACT [] is_a: GO:0034331 ! cell junction maintenance is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0045218 name: zonula adherens maintenance namespace: biological_process def: "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells." [GOC:bf] is_a: GO:0045217 ! cell-cell junction maintenance [Term] id: GO:0045219 name: regulation of FasL biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] synonym: "regulation of FasL anabolism" EXACT [] synonym: "regulation of FasL biosynthesis" EXACT [] synonym: "regulation of FasL formation" EXACT [] synonym: "regulation of FasL synthesis" EXACT [] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process relationship: regulates GO:0045210 ! FasL biosynthetic process [Term] id: GO:0045220 name: positive regulation of FasL biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] synonym: "activation of FasL biosynthetic process" NARROW [] synonym: "positive regulation of FasL anabolism" EXACT [] synonym: "positive regulation of FasL biosynthesis" EXACT [] synonym: "positive regulation of FasL formation" EXACT [] synonym: "positive regulation of FasL synthesis" EXACT [] synonym: "stimulation of FasL biosynthetic process" NARROW [] synonym: "up regulation of FasL biosynthetic process" EXACT [] synonym: "up-regulation of FasL biosynthetic process" EXACT [] synonym: "upregulation of FasL biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0045219 ! regulation of FasL biosynthetic process relationship: positively_regulates GO:0045210 ! FasL biosynthetic process [Term] id: GO:0045221 name: negative regulation of FasL biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] synonym: "down regulation of FasL biosynthetic process" EXACT [] synonym: "down-regulation of FasL biosynthetic process" EXACT [] synonym: "downregulation of FasL biosynthetic process" EXACT [] synonym: "inhibition of FasL biosynthetic process" NARROW [] synonym: "negative regulation of FasL anabolism" EXACT [] synonym: "negative regulation of FasL biosynthesis" EXACT [] synonym: "negative regulation of FasL formation" EXACT [] synonym: "negative regulation of FasL synthesis" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0045219 ! regulation of FasL biosynthetic process relationship: negatively_regulates GO:0045210 ! FasL biosynthetic process [Term] id: GO:0045222 name: CD4 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "CD4 anabolism" EXACT [] synonym: "CD4 biosynthesis" EXACT [] synonym: "CD4 formation" EXACT [] synonym: "CD4 synthesis" EXACT [] is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0045223 name: regulation of CD4 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] synonym: "regulation of CD4 anabolism" EXACT [] synonym: "regulation of CD4 biosynthesis" EXACT [] synonym: "regulation of CD4 formation" EXACT [] synonym: "regulation of CD4 synthesis" EXACT [] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process relationship: regulates GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0045224 name: positive regulation of CD4 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] synonym: "activation of CD4 biosynthetic process" NARROW [] synonym: "positive regulation of CD4 anabolism" EXACT [] synonym: "positive regulation of CD4 biosynthesis" EXACT [] synonym: "positive regulation of CD4 formation" EXACT [] synonym: "positive regulation of CD4 synthesis" EXACT [] synonym: "stimulation of CD4 biosynthetic process" NARROW [] synonym: "up regulation of CD4 biosynthetic process" EXACT [] synonym: "up-regulation of CD4 biosynthetic process" EXACT [] synonym: "upregulation of CD4 biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0045223 ! regulation of CD4 biosynthetic process relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0045225 name: negative regulation of CD4 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] synonym: "down regulation of CD4 biosynthetic process" EXACT [] synonym: "down-regulation of CD4 biosynthetic process" EXACT [] synonym: "downregulation of CD4 biosynthetic process" EXACT [] synonym: "inhibition of CD4 biosynthetic process" NARROW [] synonym: "negative regulation of CD4 anabolism" EXACT [] synonym: "negative regulation of CD4 biosynthesis" EXACT [] synonym: "negative regulation of CD4 formation" EXACT [] synonym: "negative regulation of CD4 synthesis" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0045223 ! regulation of CD4 biosynthetic process relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0045226 name: extracellular polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators] subset: gosubset_prok synonym: "extracellular polysaccharide anabolism" EXACT [] synonym: "extracellular polysaccharide biosynthesis" EXACT [] synonym: "extracellular polysaccharide formation" EXACT [] synonym: "extracellular polysaccharide synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046379 ! extracellular polysaccharide metabolic process [Term] id: GO:0045227 name: capsule polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:go_curators] subset: gosubset_prok synonym: "capsular polysaccharide biosynthesis" EXACT [] synonym: "capsular polysaccharide biosynthetic process" EXACT [] synonym: "capsule polysaccharide anabolism" EXACT [] synonym: "capsule polysaccharide biosynthesis" EXACT [] synonym: "capsule polysaccharide formation" EXACT [] synonym: "capsule polysaccharide synthesis" EXACT [] is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process is_a: GO:0045230 ! capsule organization [Term] id: GO:0045228 name: slime layer polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall." [GOC:go_curators] subset: gosubset_prok synonym: "slime layer polysaccharide anabolism" EXACT [] synonym: "slime layer polysaccharide biosynthesis" EXACT [] synonym: "slime layer polysaccharide formation" EXACT [] synonym: "slime layer polysaccharide synthesis" EXACT [] is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process is_a: GO:0045231 ! slime layer organization [Term] id: GO:0045229 name: external encapsulating structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "external encapsulating structure organisation" EXACT [GOC:curators] synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0045230 name: capsule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "capsule organisation" EXACT [GOC:curators] synonym: "capsule organization and biogenesis" RELATED [] is_a: GO:0045229 ! external encapsulating structure organization [Term] id: GO:0045231 name: slime layer organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "slime layer organisation" EXACT [GOC:curators] synonym: "slime layer organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045229 ! external encapsulating structure organization [Term] id: GO:0045232 name: S-layer organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria." [GOC:ai] synonym: "S-layer organisation" EXACT [GOC:curators] synonym: "S-layer organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045229 ! external encapsulating structure organization [Term] id: GO:0045233 name: natural killer cell receptor activity namespace: molecular_function def: "A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family." [GOC:ebc] synonym: "Ly49i" NARROW [] synonym: "NK cell receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0045234 name: protein palmitoleylation namespace: biological_process alt_id: GO:0045235 def: "The covalent attachment of a palmitoleyl group to a protein." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid palmitoleylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0045236 name: CXCR chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892] synonym: "alpha chemokine receptor binding" EXACT [] synonym: "alpha chemokine receptor ligand" NARROW [] synonym: "C-X-C chemokine receptor ligand" NARROW [] synonym: "CXC chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0045237 name: CXCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the CXCR1 chemokine receptor." [GOC:ceb, PMID:11910892] synonym: "CXCR1 chemokine receptor ligand" NARROW [] is_a: GO:0005153 ! interleukin-8 receptor binding [Term] id: GO:0045238 name: CXCR2 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the CXCR2 chemokine receptor." [GOC:ceb, PMID:11910892] synonym: "CXCR2 chemokine receptor ligand" NARROW [] is_a: GO:0005153 ! interleukin-8 receptor binding [Term] id: GO:0045239 name: tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "TCA cycle enzyme complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0045240 name: dihydrolipoyl dehydrogenase complex namespace: cellular_component def: "A protein complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah] subset: gosubset_prok synonym: "2-oxoglutarate dehydrogenase complex" EXACT [] synonym: "alpha-ketoglutarate dehydrogenase complex" EXACT [] is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex [Term] id: GO:0045241 name: cytosolic alpha-ketoglutarate dehydrogenase complex namespace: cellular_component def: "Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex [Term] id: GO:0045242 name: isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah] subset: gosubset_prok is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex [Term] id: GO:0045243 name: cytosolic isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "isocitrate dehydrogenase complex (NAD+)" BROAD [] is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex [Term] id: GO:0045244 name: succinate-CoA ligase complex (GDP-forming) namespace: cellular_component alt_id: GO:0008325 alt_id: GO:0045245 def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [EC:6.2.1.4, GOC:jl] synonym: "succinyl-CoA synthetase, GDP-forming" EXACT [CORUM:392] is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0042709 ! succinate-CoA ligase complex [Term] id: GO:0045246 name: cytosolic tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] subset: gosubset_prok synonym: "TCA cycle enzyme complex" BROAD [] synonym: "tricarboxylic acid cycle enzyme complex " BROAD [] is_a: GO:0044445 ! cytosolic part is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex [Term] id: GO:0045247 name: cytosolic electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0044445 ! cytosolic part is_a: GO:0045251 ! electron transfer flavoprotein complex [Term] id: GO:0045248 name: cytosolic oxoglutarate dehydrogenase complex namespace: cellular_component def: "A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [GOC:mtg_sensu, PMID:10848975] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. subset: gosubset_prok is_a: GO:0044445 ! cytosolic part is_a: GO:0045252 ! oxoglutarate dehydrogenase complex [Term] id: GO:0045249 name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, PMID:9395502] comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. subset: gosubset_prok is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex [Term] id: GO:0045250 name: cytosolic pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order." [GOC:mtg_sensu, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. subset: gosubset_prok synonym: "pyruvate dehydrogenase complex (lipoamide)" RELATED [] is_a: GO:0045254 ! pyruvate dehydrogenase complex [Term] id: GO:0045251 name: electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0045252 name: oxoglutarate dehydrogenase complex namespace: cellular_component def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. subset: goslim_pir subset: gosubset_prok synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0045253 name: pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [PMID:9395502] comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0045254 name: pyruvate dehydrogenase complex namespace: cellular_component alt_id: GO:0009364 def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. subset: goslim_pir subset: gosubset_prok synonym: "dihydrolipoyl dehydrogenase complex" BROAD [] synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT [] xref: Wikipedia:Pyruvate_dehydrogenase_complex is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0045257 name: succinate dehydrogenase complex (ubiquinone) namespace: cellular_component def: "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, ISBN:0198547684] subset: gosubset_prok is_a: GO:0045281 ! succinate dehydrogenase complex [Term] id: GO:0045258 name: plasma membrane succinate dehydrogenase complex (ubiquinone) namespace: cellular_component def: "The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) is_a: GO:0045282 ! plasma membrane succinate dehydrogenase complex [Term] id: GO:0045259 name: proton-transporting ATP synthase complex namespace: cellular_component alt_id: GO:0045255 def: "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [EC:3.6.3.14, ISBN:0198547684, ISBN:0716743663] subset: gosubset_prok synonym: "hydrogen-translocating F-type ATPase complex" EXACT [] synonym: "hydrogen-transporting ATP synthase complex" EXACT [] synonym: "proton-transporting F-type ATPase complex" RELATED [] is_a: GO:0016469 ! proton-transporting two-sector ATPase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0045260 name: plasma membrane proton-transporting ATP synthase complex namespace: cellular_component alt_id: GO:0045256 def: "A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "hydrogen-translocating F-type ATPase complex " BROAD [] synonym: "hydrogen-transporting ATP synthase" EXACT [] synonym: "plasma membrane hydrogen-translocating F-type ATPase complex" EXACT [] synonym: "proton-transporting ATP synthase complex" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045259 ! proton-transporting ATP synthase complex [Term] id: GO:0045261 name: proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, F1 sector" EXACT [] is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain is_a: GO:0044424 ! intracellular part relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex [Term] id: GO:0045262 name: plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'plasma membrane ; GO:0005886'. subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex [Term] id: GO:0045263 name: proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase complex, coupling factor F(o)" EXACT [GOC:mah] synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" NARROW [] synonym: "hydrogen-transporting ATP synthase, F0 sector" EXACT [] synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" EXACT [] is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain is_a: GO:0044424 ! intracellular part relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex [Term] id: GO:0045264 name: plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins." [GOC:mah, GOC:mtg_sensu, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, F0 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" BROAD [] synonym: "proton-transporting ATP synthase complex, coupling factor F(o)" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex [Term] id: GO:0045265 name: proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, stator stalk" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part is_a: GO:0044425 ! membrane part relationship: part_of GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0045266 name: plasma membrane proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, stator stalk" BROAD [] synonym: "proton-transporting ATP synthase, stator stalk" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk relationship: part_of GO:0045264 ! plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0045267 name: proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, catalytic core" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part is_a: GO:0044425 ! membrane part relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0045268 name: plasma membrane proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, catalytic core" BROAD [] synonym: "proton-transporting ATP synthase, catalytic core" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0045269 name: proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, central stalk" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part is_a: GO:0044425 ! membrane part relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0045270 name: plasma membrane proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056] subset: gosubset_prok synonym: "hydrogen-transporting ATP synthase, central stalk" BROAD [] synonym: "proton-transporting ATP synthase, central stalk" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0045271 name: respiratory chain complex I namespace: cellular_component alt_id: GO:0045279 def: "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:jid, ISBN:0716749556] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'. subset: gosubset_prok synonym: "electron transport complex I" RELATED [] synonym: "NADH dehydrogenase (ubiquinone) complex" EXACT [] synonym: "NADH dehydrogenase complex (ubiquinone)" EXACT [] synonym: "NADH-Q oxidoreductase complex" EXACT [] is_a: GO:0030964 ! NADH dehydrogenase complex relationship: part_of GO:0070469 ! respiratory chain [Term] id: GO:0045272 name: plasma membrane respiratory chain complex I namespace: cellular_component def: "A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "NADH dehydrogenase (ubiquinone) complex" BROAD [] synonym: "respiratory chain complex I" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045271 ! respiratory chain complex I relationship: part_of GO:0070470 ! plasma membrane respiratory chain [Term] id: GO:0045273 name: respiratory chain complex II namespace: cellular_component def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok synonym: "electron transport complex II" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part is_a: GO:0044425 ! membrane part relationship: part_of GO:0070469 ! respiratory chain [Term] id: GO:0045274 name: plasma membrane respiratory chain complex II namespace: cellular_component def: "A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "respiratory chain complex II" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045273 ! respiratory chain complex II relationship: part_of GO:0070470 ! plasma membrane respiratory chain [Term] id: GO:0045275 name: respiratory chain complex III namespace: cellular_component alt_id: GO:0032842 alt_id: GO:0045285 def: "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733] subset: goslim_pir subset: gosubset_prok synonym: "complex III" EXACT [] synonym: "cytochrome bc(1) complex" EXACT [] synonym: "cytochrome bc1 complex" EXACT [] synonym: "electron transport complex III" RELATED [] synonym: "ubiquinol-cytochrome c oxidoreductase complex" EXACT [] synonym: "ubiquinol-cytochrome-c reductase complex" EXACT [] xref: Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part is_a: GO:0044425 ! membrane part relationship: part_of GO:0070469 ! respiratory chain [Term] id: GO:0045276 name: plasma membrane respiratory chain complex III namespace: cellular_component alt_id: GO:0045286 def: "A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "plasma membrane ubiquinol-cytochrome-c reductase complex" EXACT [] synonym: "respiratory chain complex III" BROAD [] synonym: "ubiquinol-cytochrome c oxidoreductase complex" BROAD [] synonym: "ubiquinol-cytochrome-c reductase complex" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045275 ! respiratory chain complex III relationship: part_of GO:0070470 ! plasma membrane respiratory chain [Term] id: GO:0045277 name: respiratory chain complex IV namespace: cellular_component alt_id: GO:0045287 def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok synonym: "cytochrome c oxidase complex" EXACT [] synonym: "electron transport complex IV" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part is_a: GO:0044425 ! membrane part relationship: part_of GO:0070469 ! respiratory chain [Term] id: GO:0045278 name: plasma membrane respiratory chain complex IV namespace: cellular_component alt_id: GO:0045288 def: "A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in Bacterial species." [GOC:mtg_sensu, ISBN:0198547684] subset: gosubset_prok synonym: "cytochrome c oxidase complex" BROAD [] synonym: "respiratory chain complex IV" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045277 ! respiratory chain complex IV relationship: part_of GO:0070470 ! plasma membrane respiratory chain [Term] id: GO:0045281 name: succinate dehydrogenase complex namespace: cellular_component def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part is_a: GO:0044425 ! membrane part relationship: part_of GO:0045273 ! respiratory chain complex II [Term] id: GO:0045282 name: plasma membrane succinate dehydrogenase complex namespace: cellular_component def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701] subset: gosubset_prok synonym: "succinate dehydrogenase complex" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045281 ! succinate dehydrogenase complex relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II [Term] id: GO:0045283 name: fumarate reductase complex namespace: cellular_component def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224] comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part is_a: GO:0044425 ! membrane part relationship: part_of GO:0045273 ! respiratory chain complex II [Term] id: GO:0045284 name: plasma membrane fumarate reductase complex namespace: cellular_component def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in Bacterial species." [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224] comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. subset: gosubset_prok synonym: "fumarate reductase complex" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0045283 ! fumarate reductase complex relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II [Term] id: GO:0045289 name: luciferin monooxygenase activity namespace: molecular_function def: "Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." [GOC:bf] synonym: "luciferase activity" EXACT [] synonym: "luciferase monooxygenase activity" RELATED [] is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0045290 name: D-arabinose 1-dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+." [EC:1.1.1.117] synonym: "D-arabinose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.117] xref: EC:1.1.1.117 xref: MetaCyc:1.1.1.117-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0045291 name: nuclear mRNA trans splicing, SL addition namespace: biological_process def: "The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body." [GOC:krc, ISBN:0879695897, PMID:2675423] synonym: "nuclear mRNA trans splicing, spliced leader addition" EXACT [] is_a: GO:0000365 ! nuclear mRNA trans splicing, via spliceosome [Term] id: GO:0045292 name: nuclear mRNA cis splicing, via spliceosome namespace: biological_process def: "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, http://calspace.ucsd.edu/origins/Glossary/C.htm, ISBN:0879695897] synonym: "nuclear mRNA cis splicing, via U2-type spliceosome" NARROW [] synonym: "splicing" BROAD [GOC:vw] is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0045293 name: mRNA editing complex namespace: cellular_component def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607] subset: goslim_pir synonym: "editosome" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0045294 name: alpha-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the alpha subunit of the catenin complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0045295 name: gamma-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the gamma subunit of the catenin complex." [GOC:bf] synonym: "plakoglobin binding" EXACT [GOC:BHF] is_a: GO:0005515 ! protein binding [Term] id: GO:0045296 name: cadherin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] is_a: GO:0050839 ! cell adhesion molecule binding [Term] id: GO:0045297 name: post-mating behavior namespace: biological_process def: "The specific actions or reactions of an organism following mating." [GOC:bf] synonym: "post-mating behaviour" EXACT [] is_a: GO:0019098 ! reproductive behavior [Term] id: GO:0045298 name: tubulin complex namespace: cellular_component def: "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [ISBN:0716731363] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part [Term] id: GO:0045299 name: otolith mineralization namespace: biological_process def: "The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873] is_a: GO:0031214 ! biomineral tissue development relationship: part_of GO:0048840 ! otolith development [Term] id: GO:0045300 name: acyl-[acyl-carrier-protein] desaturase activity namespace: molecular_function def: "Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin." [EC:1.14.19.2] comment: Note that this function was formerly EC:1.14.99.6. subset: gosubset_prok synonym: "acyl-[acyl-carrier protein] desaturase activity" EXACT [] synonym: "acyl-acyl-carrier-protein desaturase activity" EXACT [EC:1.14.19.2] synonym: "acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.2] synonym: "stearyl acyl carrier protein desaturase activity" EXACT [EC:1.14.19.2] synonym: "stearyl-ACP desaturase activity" EXACT [EC:1.14.19.2] xref: EC:1.14.19.2 xref: MetaCyc:1.14.19.2-RXN xref: MetaCyc:PWY-5147 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0045301 name: tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin." [GOC:mlg, PMID:8253666] subset: gosubset_prok synonym: "2-methylthio-cis-ribozeatin hydroxylase activity" EXACT [] synonym: "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity" EXACT [] synonym: "tRNA-(ms2io6A)-hydroxylase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0045302 name: choloylglycine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine." [EC:3.5.1.24] subset: gosubset_prok synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity" EXACT [EC:3.5.1.24] synonym: "bile salt hydrolase activity" EXACT [EC:3.5.1.24] synonym: "choloyltaurine hydrolase activity" EXACT [EC:3.5.1.24] synonym: "glycocholase activity" EXACT [EC:3.5.1.24] xref: EC:3.5.1.24 xref: MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0045303 name: diaminobutyrate-2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate." [EC:2.6.1.76, RHEA:11163] subset: gosubset_prok synonym: "2,4-diaminobutyrate 4-aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "DAB aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "DABA aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "diaminibutyric acid aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "diaminobutyrate transaminase activity" EXACT [EC:2.6.1.76] synonym: "diaminobutyrate--2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "EctB" RELATED [EC:2.6.1.76] synonym: "L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] xref: EC:2.6.1.76 xref: KEGG:R06977 xref: MetaCyc:R101-RXN xref: RHEA:11163 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0045304 name: regulation of establishment of competence for transformation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome." [GOC:mlg] subset: gosubset_prok synonym: "regulator of establishment of competence for transformation activity" RELATED [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032104 ! regulation of response to extracellular stimulus is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0030420 ! establishment of competence for transformation [Term] id: GO:0045305 name: regulator of establishment of competence for transformation activity namespace: molecular_function def: "OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation." [GOC:mlg] comment: This term was made obsolete because it does not represent a true function. is_obsolete: true replaced_by: GO:0045304 [Term] id: GO:0045306 name: inhibitor of the establishment of competence for transformation activity namespace: molecular_function def: "OBSOLETE. Inhibits the establishment of competence for transformation." [GOC:mlg] comment: This term was made obsolete because it does not represent a true function. is_obsolete: true replaced_by: GO:0045808 [Term] id: GO:0045307 name: activator of the establishment of competence for transformation activity namespace: molecular_function def: "OBSOLETE. Activates the establishment of competence for transformation." [GOC:mlg] comment: This term was made obsolete because it does not represent a true function. is_obsolete: true replaced_by: GO:0045809 [Term] id: GO:0045309 name: protein phosphorylated amino acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein." [GOC:go_curators] synonym: "phosphoprotein amino acid binding" RELATED [] is_a: GO:0051219 ! phosphoprotein binding [Term] id: GO:0045310 name: phosphoserine/phosphothreonine binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein." [GOC:go_curators] comment: This term was made obsolete because it represents two functions. is_obsolete: true consider: GO:0050815 consider: GO:0050816 [Term] id: GO:0045311 name: invasive growth in response to pheromone namespace: biological_process def: "The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus." [GOC:ai, GOC:dph, GOC:mcc] is_a: GO:0019236 ! response to pheromone is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0045312 name: nor-spermidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators] synonym: "nor-spermidine anabolism" EXACT [] synonym: "nor-spermidine biosynthesis" EXACT [] synonym: "nor-spermidine formation" EXACT [] synonym: "nor-spermidine synthesis" EXACT [] is_a: GO:0008295 ! spermidine biosynthetic process is_a: GO:0046204 ! nor-spermidine metabolic process [Term] id: GO:0045313 name: rhabdomere membrane biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl] is_a: GO:0044091 ! membrane biogenesis relationship: part_of GO:0042052 ! rhabdomere development [Term] id: GO:0045314 name: regulation of compound eye photoreceptor development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] synonym: "regulation of eye photoreceptor development" BROAD [] is_a: GO:0042478 ! regulation of eye photoreceptor cell development relationship: part_of GO:0046532 ! regulation of photoreceptor cell differentiation relationship: regulates GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0045315 name: positive regulation of compound eye photoreceptor development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] synonym: "activation of eye photoreceptor development" BROAD [] synonym: "positive regulation of eye photoreceptor development" BROAD [] synonym: "stimulation of eye photoreceptor development" BROAD [] synonym: "up regulation of eye photoreceptor development" BROAD [] synonym: "up-regulation of eye photoreceptor development" BROAD [] synonym: "upregulation of eye photoreceptor development" BROAD [] is_a: GO:0042479 ! positive regulation of eye photoreceptor cell development is_a: GO:0045314 ! regulation of compound eye photoreceptor development relationship: positively_regulates GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0045316 name: negative regulation of compound eye photoreceptor development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] synonym: "down regulation of eye photoreceptor development" BROAD [] synonym: "down-regulation of eye photoreceptor development" BROAD [] synonym: "downregulation of eye photoreceptor development" BROAD [] synonym: "inhibition of eye photoreceptor development" BROAD [] synonym: "negative regulation of eye photoreceptor development" BROAD [] is_a: GO:0042480 ! negative regulation of eye photoreceptor cell development is_a: GO:0045314 ! regulation of compound eye photoreceptor development relationship: negatively_regulates GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0045317 name: equator specification namespace: biological_process def: "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity [Term] id: GO:0045319 name: SRP-independent cotranslational protein-membrane targeting, translocation namespace: biological_process def: "OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition." [GOC:ai] comment: This term was made obsolete because there is no evidence for the existence of this process. synonym: "SRP-independent cotranslational membrane targeting, translocation" EXACT [] is_obsolete: true [Term] id: GO:0045320 name: chloroplast proton-transporting ATP synthase complex namespace: cellular_component def: "A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation." [GOC:mtg_sensu, GOC:pj, ISBN:0716743663] synonym: "chloroplast hydrogen-translocating F-type ATPase complex" EXACT [] synonym: "chloroplast proton-transporting F-type ATPase complex" EXACT [] synonym: "hydrogen-translocating F-type ATPase complex" BROAD [] is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part is_a: GO:0045259 ! proton-transporting ATP synthase complex relationship: part_of GO:0009535 ! chloroplast thylakoid membrane [Term] id: GO:0045321 name: leukocyte activation namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] synonym: "immune cell activation" EXACT [] synonym: "leucocyte activation" EXACT [] xref: Wikipedia:Immunologic_activation is_a: GO:0001775 ! cell activation is_a: GO:0002376 ! immune system process [Term] id: GO:0045322 name: unmethylated CpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters." [GOC:ai, PMID:10688657] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0045323 name: interleukin-1 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075] synonym: "IL-1 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0045324 name: late endosome to vacuole transport namespace: biological_process def: "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141] is_a: GO:0007034 ! vacuolar transport is_a: GO:0016197 ! endosome transport [Term] id: GO:0045325 name: peptidyl-tryptophan hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan." [RESID:AA0322] subset: gosubset_prok xref: RESID:AA0322 is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0045326 name: protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine." [RESID:AA0323] subset: gosubset_prok synonym: "DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine" EXACT [GOC:mah] xref: RESID:AA0323 is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine [Term] id: GO:0045327 name: protein-DNA covalent cross-linking via peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue." [GOC:jsg] subset: gosubset_prok synonym: "DNA-protein covalent cross-linking via peptidyl-tyrosine" EXACT [GOC:mah] is_a: GO:0018142 ! protein-DNA covalent cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0045328 name: cytochrome P450 4A1-heme linkage namespace: biological_process def: "The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester." [RESID:AA0324] subset: gosubset_prok synonym: "cytochrome P450 4A1-haem linkage" EXACT [] xref: RESID:AA0324 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0045329 name: carnitine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "carnitine anabolism" EXACT [] synonym: "carnitine biosynthesis" EXACT [] synonym: "carnitine formation" EXACT [] synonym: "carnitine synthesis" EXACT [] synonym: "vitamin Bt biosynthesis" EXACT [] synonym: "vitamin Bt biosynthetic process" EXACT [] xref: Reactome:1252956 "Carnitine synthesis" xref: Reactome:1279886 "Carnitine synthesis" xref: Reactome:1298798 "Carnitine synthesis" xref: Reactome:1326459 "Carnitine synthesis" xref: Reactome:1352575 "Carnitine synthesis" xref: Reactome:1372802 "Carnitine synthesis" xref: Reactome:1392812 "Carnitine synthesis" xref: Reactome:1417285 "Carnitine synthesis" xref: Reactome:1450378 "Carnitine synthesis" xref: Reactome:1470908 "Carnitine synthesis" xref: Reactome:1482945 "Carnitine synthesis" xref: Reactome:1496730 "Carnitine synthesis" xref: Reactome:1514120 "Carnitine synthesis" xref: Reactome:1526695 "Carnitine synthesis" xref: Reactome:1532422 "Carnitine synthesis" xref: Reactome:1535976 "Carnitine synthesis" xref: Reactome:1537990 "Carnitine synthesis" xref: Reactome:71262 "Carnitine synthesis" is_a: GO:0006578 ! betaine biosynthetic process is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009437 ! carnitine metabolic process [Term] id: GO:0045330 name: aspartyl esterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue." [GOC:mah, SP_KW:KW-0063] subset: gosubset_prok is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0045331 name: coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate." [EC:1.12.99.2] comment: This term was made obsolete because it represents two activities. synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulphide hydrogenase activity" EXACT [] synonym: "heterodisulfide reductase activity" EXACT [] is_obsolete: true replaced_by: GO:0051911 replaced_by: GO:0051912 [Term] id: GO:0045332 name: phospholipid translocation namespace: biological_process def: "The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864] comment: Note that this term describes the transbilayer motion of individual phospholipid molecules, and should not be confused with 'phospholipid scrambling ; GO:0017121'. subset: gosubset_prok synonym: "flippase" RELATED [] is_a: GO:0015914 ! phospholipid transport is_a: GO:0034204 ! lipid translocation [Term] id: GO:0045333 name: cellular respiration namespace: biological_process def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [ISBN:0140513590, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "oxidative metabolic process" EXACT [] synonym: "oxidative metabolism" EXACT [] synonym: "respiration" BROAD [] xref: Wikipedia:Cellular_respiration is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0045334 name: clathrin-coated endocytic vesicle namespace: cellular_component def: "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators] xref: NIF_Subcellular:sao1243595998 is_a: GO:0030136 ! clathrin-coated vesicle is_a: GO:0030139 ! endocytic vesicle [Term] id: GO:0045335 name: phagocytic vesicle namespace: cellular_component def: "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "phagosome" EXACT [] xref: Wikipedia:Phagosome is_a: GO:0030139 ! endocytic vesicle [Term] id: GO:0045336 name: clathrin-coated phagocytic vesicle namespace: cellular_component def: "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "clathrin-coated phagosome" EXACT [] is_a: GO:0045334 ! clathrin-coated endocytic vesicle is_a: GO:0045335 ! phagocytic vesicle [Term] id: GO:0045337 name: farnesyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of farnesyl diphosphate." [GOC:jl] subset: gosubset_prok synonym: "farnesyl diphosphate anabolism" EXACT [] synonym: "farnesyl diphosphate biosynthesis" EXACT [] synonym: "farnesyl diphosphate formation" EXACT [] synonym: "farnesyl diphosphate synthesis" EXACT [] xref: MetaCyc:PWY-5123 is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016091 ! prenol biosynthetic process is_a: GO:0045338 ! farnesyl diphosphate metabolic process [Term] id: GO:0045338 name: farnesyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation." [GOC:go_curators] subset: gosubset_prok synonym: "farnesyl diphosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0016090 ! prenol metabolic process [Term] id: GO:0045339 name: farnesyl diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "farnesyl diphosphate breakdown" EXACT [] synonym: "farnesyl diphosphate catabolism" EXACT [] synonym: "farnesyl diphosphate degradation" EXACT [] is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0016092 ! prenol catabolic process is_a: GO:0045338 ! farnesyl diphosphate metabolic process [Term] id: GO:0045340 name: mercury ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with mercury (Hg) ions." [GOC:go_curators] subset: gosubset_prok synonym: "mercury binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0045341 name: MHC class I biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I." [GOC:go_curators] synonym: "major histocompatibility complex class I biosynthesis" EXACT [] synonym: "major histocompatibility complex class I biosynthetic process" EXACT [] synonym: "MHC class I anabolism" EXACT [] synonym: "MHC class I biosynthesis" EXACT [] synonym: "MHC class I formation" EXACT [] synonym: "MHC class I synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0045342 name: MHC class II biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II." [GOC:go_curators] synonym: "major histocompatibility complex class II biosynthesis" EXACT [] synonym: "major histocompatibility complex class II biosynthetic process" EXACT [] synonym: "MHC class II anabolism" EXACT [] synonym: "MHC class II biosynthesis" EXACT [] synonym: "MHC class II formation" EXACT [] synonym: "MHC class II synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0045343 name: regulation of MHC class I biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] synonym: "regulation of major histocompatibility complex class I biosynthesis" EXACT [] synonym: "regulation of major histocompatibility complex class I biosynthetic process" EXACT [] synonym: "regulation of MHC class I anabolism" EXACT [] synonym: "regulation of MHC class I biosynthesis" EXACT [] synonym: "regulation of MHC class I formation" EXACT [] synonym: "regulation of MHC class I synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process relationship: regulates GO:0045341 ! MHC class I biosynthetic process [Term] id: GO:0045344 name: negative regulation of MHC class I biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] synonym: "down regulation of MHC class I biosynthetic process" EXACT [] synonym: "down-regulation of MHC class I biosynthetic process" EXACT [] synonym: "downregulation of MHC class I biosynthetic process" EXACT [] synonym: "inhibition of MHC class I biosynthetic process" NARROW [] synonym: "negative regulation of major histocompatibility complex class I biosynthesis" EXACT [] synonym: "negative regulation of major histocompatibility complex class I biosynthetic process" EXACT [] synonym: "negative regulation of MHC class I anabolism" EXACT [] synonym: "negative regulation of MHC class I biosynthesis" EXACT [] synonym: "negative regulation of MHC class I formation" EXACT [] synonym: "negative regulation of MHC class I synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0045343 ! regulation of MHC class I biosynthetic process relationship: negatively_regulates GO:0045341 ! MHC class I biosynthetic process [Term] id: GO:0045345 name: positive regulation of MHC class I biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] synonym: "activation of MHC class I biosynthetic process" NARROW [] synonym: "positive regulation of major histocompatibility complex class I biosynthesis" EXACT [] synonym: "positive regulation of major histocompatibility complex class I biosynthetic process" EXACT [] synonym: "positive regulation of MHC class I anabolism" EXACT [] synonym: "positive regulation of MHC class I biosynthesis" EXACT [] synonym: "positive regulation of MHC class I formation" EXACT [] synonym: "positive regulation of MHC class I synthesis" EXACT [] synonym: "stimulation of MHC class I biosynthetic process" NARROW [] synonym: "up regulation of MHC class I biosynthetic process" EXACT [] synonym: "up-regulation of MHC class I biosynthetic process" EXACT [] synonym: "upregulation of MHC class I biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0045343 ! regulation of MHC class I biosynthetic process relationship: positively_regulates GO:0045341 ! MHC class I biosynthetic process [Term] id: GO:0045346 name: regulation of MHC class II biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] synonym: "regulation of major histocompatibility complex class II biosynthesis" EXACT [] synonym: "regulation of major histocompatibility complex class II biosynthetic process" EXACT [] synonym: "regulation of MHC class II anabolism" EXACT [] synonym: "regulation of MHC class II biosynthesis" EXACT [] synonym: "regulation of MHC class II formation" EXACT [] synonym: "regulation of MHC class II synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process relationship: regulates GO:0045342 ! MHC class II biosynthetic process [Term] id: GO:0045347 name: negative regulation of MHC class II biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] synonym: "down regulation of MHC class II biosynthetic process" EXACT [] synonym: "down-regulation of MHC class II biosynthetic process" EXACT [] synonym: "downregulation of MHC class II biosynthetic process" EXACT [] synonym: "inhibition of MHC class II biosynthetic process" NARROW [] synonym: "negative regulation of major histocompatibility complex class II biosynthesis" EXACT [] synonym: "negative regulation of major histocompatibility complex class II biosynthetic process" EXACT [] synonym: "negative regulation of MHC class II anabolism" EXACT [] synonym: "negative regulation of MHC class II biosynthesis" EXACT [] synonym: "negative regulation of MHC class II formation" EXACT [] synonym: "negative regulation of MHC class II synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0045346 ! regulation of MHC class II biosynthetic process relationship: negatively_regulates GO:0045342 ! MHC class II biosynthetic process [Term] id: GO:0045348 name: positive regulation of MHC class II biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] synonym: "activation of MHC class II biosynthetic process" NARROW [] synonym: "positive regulation of major histocompatibility complex class II biosynthesis" EXACT [] synonym: "positive regulation of major histocompatibility complex class II biosynthetic process" EXACT [] synonym: "positive regulation of MHC class II anabolism" EXACT [] synonym: "positive regulation of MHC class II biosynthesis" EXACT [] synonym: "positive regulation of MHC class II formation" EXACT [] synonym: "positive regulation of MHC class II synthesis" EXACT [] synonym: "stimulation of MHC class II biosynthetic process" NARROW [] synonym: "up regulation of MHC class II biosynthetic process" EXACT [] synonym: "up-regulation of MHC class II biosynthetic process" EXACT [] synonym: "upregulation of MHC class II biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0045346 ! regulation of MHC class II biosynthetic process relationship: positively_regulates GO:0045342 ! MHC class II biosynthetic process [Term] id: GO:0045349 name: interferon-alpha biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] synonym: "IFN-alpha biosynthesis" EXACT [] synonym: "IFN-alpha biosynthetic process" EXACT [] synonym: "interferon-alpha anabolism" EXACT [] synonym: "interferon-alpha biosynthesis" EXACT [] synonym: "interferon-alpha formation" EXACT [] synonym: "interferon-alpha synthesis" EXACT [] is_a: GO:0045351 ! type I interferon biosynthetic process relationship: part_of GO:0032607 ! interferon-alpha production [Term] id: GO:0045350 name: interferon-beta biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] synonym: "IFN-beta biosynthesis" EXACT [] synonym: "IFN-beta biosynthetic process" EXACT [] synonym: "IFNB biosynthetic process" EXACT [GOC:mah] synonym: "interferon-beta anabolism" EXACT [] synonym: "interferon-beta biosynthesis" EXACT [] synonym: "interferon-beta formation" EXACT [] synonym: "interferon-beta synthesis" EXACT [] is_a: GO:0045351 ! type I interferon biosynthetic process relationship: part_of GO:0032608 ! interferon-beta production [Term] id: GO:0045351 name: type I interferon biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add] synonym: "interferon type I biosynthetic process" EXACT [] synonym: "type I interferon anabolism" EXACT [] synonym: "type I interferon biosynthesis" EXACT [] synonym: "type I interferon formation" EXACT [] synonym: "type I interferon synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032606 ! type I interferon production [Term] id: GO:0045352 name: interleukin-1 Type I receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to interleukin-1 Type I receptors." [GOC:ebc] synonym: "IL-1ra type I" EXACT [] is_a: GO:0005152 ! interleukin-1 receptor antagonist activity [Term] id: GO:0045353 name: interleukin-1 Type II receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to interleukin-1 Type II receptors." [GOC:ebc] synonym: "IL-1ra type II" EXACT [] is_a: GO:0005152 ! interleukin-1 receptor antagonist activity [Term] id: GO:0045354 name: regulation of interferon-alpha biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] synonym: "regulation of interferon-alpha anabolism" EXACT [] synonym: "regulation of interferon-alpha biosynthesis" EXACT [] synonym: "regulation of interferon-alpha formation" EXACT [] synonym: "regulation of interferon-alpha synthesis" EXACT [] is_a: GO:0032647 ! regulation of interferon-alpha production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0045349 ! interferon-alpha biosynthetic process [Term] id: GO:0045355 name: negative regulation of interferon-alpha biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] synonym: "down regulation of interferon-alpha biosynthetic process" EXACT [] synonym: "down-regulation of interferon-alpha biosynthetic process" EXACT [] synonym: "downregulation of interferon-alpha biosynthetic process" EXACT [] synonym: "inhibition of interferon-alpha biosynthetic process" NARROW [] synonym: "negative regulation of interferon-alpha anabolism" EXACT [] synonym: "negative regulation of interferon-alpha biosynthesis" EXACT [] synonym: "negative regulation of interferon-alpha formation" EXACT [] synonym: "negative regulation of interferon-alpha synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process relationship: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process [Term] id: GO:0045356 name: positive regulation of interferon-alpha biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] synonym: "activation of interferon-alpha biosynthetic process" NARROW [] synonym: "positive regulation of interferon-alpha anabolism" EXACT [] synonym: "positive regulation of interferon-alpha biosynthesis" EXACT [] synonym: "positive regulation of interferon-alpha formation" EXACT [] synonym: "positive regulation of interferon-alpha synthesis" EXACT [] synonym: "stimulation of interferon-alpha biosynthetic process" NARROW [] synonym: "up regulation of interferon-alpha biosynthetic process" EXACT [] synonym: "up-regulation of interferon-alpha biosynthetic process" EXACT [] synonym: "upregulation of interferon-alpha biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process relationship: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process [Term] id: GO:0045357 name: regulation of interferon-beta biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] synonym: "regulation of interferon-beta anabolism" EXACT [] synonym: "regulation of interferon-beta biosynthesis" EXACT [] synonym: "regulation of interferon-beta formation" EXACT [] synonym: "regulation of interferon-beta synthesis" EXACT [] is_a: GO:0032648 ! regulation of interferon-beta production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0045350 ! interferon-beta biosynthetic process [Term] id: GO:0045358 name: negative regulation of interferon-beta biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] synonym: "down regulation of interferon-beta biosynthetic process" EXACT [] synonym: "down-regulation of interferon-beta biosynthetic process" EXACT [] synonym: "downregulation of interferon-beta biosynthetic process" EXACT [] synonym: "inhibition of interferon-beta biosynthetic process" NARROW [] synonym: "negative regulation of interferon-beta anabolism" EXACT [] synonym: "negative regulation of interferon-beta biosynthesis" EXACT [] synonym: "negative regulation of interferon-beta formation" EXACT [] synonym: "negative regulation of interferon-beta synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process relationship: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process [Term] id: GO:0045359 name: positive regulation of interferon-beta biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] synonym: "activation of interferon-beta biosynthetic process" NARROW [] synonym: "positive regulation of interferon-beta anabolism" EXACT [] synonym: "positive regulation of interferon-beta biosynthesis" EXACT [] synonym: "positive regulation of interferon-beta formation" EXACT [] synonym: "positive regulation of interferon-beta synthesis" EXACT [] synonym: "stimulation of interferon-beta biosynthetic process" NARROW [] synonym: "up regulation of interferon-beta biosynthetic process" EXACT [] synonym: "up-regulation of interferon-beta biosynthetic process" EXACT [] synonym: "upregulation of interferon-beta biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process relationship: positively_regulates GO:0045350 ! interferon-beta biosynthetic process [Term] id: GO:0045360 name: regulation of interleukin-1 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] synonym: "regulation of IL-1 biosynthesis" EXACT [] synonym: "regulation of IL-1 biosynthetic process" EXACT [] synonym: "regulation of interleukin-1 anabolism" EXACT [] synonym: "regulation of interleukin-1 biosynthesis" EXACT [] synonym: "regulation of interleukin-1 formation" EXACT [] synonym: "regulation of interleukin-1 synthesis" EXACT [] is_a: GO:0032652 ! regulation of interleukin-1 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042222 ! interleukin-1 biosynthetic process [Term] id: GO:0045361 name: negative regulation of interleukin-1 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] synonym: "down regulation of interleukin-1 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-1 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-1 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-1 biosynthetic process" NARROW [] synonym: "negative regulation of IL-1 biosynthesis" EXACT [] synonym: "negative regulation of IL-1 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-1 anabolism" EXACT [] synonym: "negative regulation of interleukin-1 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-1 formation" EXACT [] synonym: "negative regulation of interleukin-1 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process relationship: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process [Term] id: GO:0045362 name: positive regulation of interleukin-1 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] synonym: "activation of interleukin-1 biosynthetic process" NARROW [] synonym: "positive regulation of IL-1 biosynthesis" EXACT [] synonym: "positive regulation of IL-1 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-1 anabolism" EXACT [] synonym: "positive regulation of interleukin-1 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-1 formation" EXACT [] synonym: "positive regulation of interleukin-1 synthesis" EXACT [] synonym: "stimulation of interleukin-1 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-1 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-1 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-1 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process relationship: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process [Term] id: GO:0045363 name: regulation of interleukin-11 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] synonym: "regulation of IL-11 biosynthesis" EXACT [] synonym: "regulation of IL-11 biosynthetic process" EXACT [] synonym: "regulation of interleukin-11 anabolism" EXACT [] synonym: "regulation of interleukin-11 biosynthesis" EXACT [] synonym: "regulation of interleukin-11 formation" EXACT [] synonym: "regulation of interleukin-11 synthesis" EXACT [] is_a: GO:0032654 ! regulation of interleukin-11 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042230 ! interleukin-11 biosynthetic process [Term] id: GO:0045364 name: negative regulation of interleukin-11 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] synonym: "down regulation of interleukin-11 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-11 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-11 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-11 biosynthetic process" NARROW [] synonym: "negative regulation of IL-11 biosynthesis" EXACT [] synonym: "negative regulation of IL-11 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-11 anabolism" EXACT [] synonym: "negative regulation of interleukin-11 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-11 formation" EXACT [] synonym: "negative regulation of interleukin-11 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process relationship: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process [Term] id: GO:0045365 name: positive regulation of interleukin-11 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] synonym: "activation of interleukin-11 biosynthetic process" NARROW [] synonym: "positive regulation of IL-11 biosynthesis" EXACT [] synonym: "positive regulation of IL-11 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-11 anabolism" EXACT [] synonym: "positive regulation of interleukin-11 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-11 formation" EXACT [] synonym: "positive regulation of interleukin-11 synthesis" EXACT [] synonym: "stimulation of interleukin-11 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-11 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-11 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-11 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process relationship: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process [Term] id: GO:0045366 name: regulation of interleukin-13 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] synonym: "regulation of IL-13 biosynthesis" EXACT [] synonym: "regulation of IL-13 biosynthetic process" EXACT [] synonym: "regulation of interleukin-13 anabolism" EXACT [] synonym: "regulation of interleukin-13 biosynthesis" EXACT [] synonym: "regulation of interleukin-13 formation" EXACT [] synonym: "regulation of interleukin-13 synthesis" EXACT [] is_a: GO:0032656 ! regulation of interleukin-13 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042231 ! interleukin-13 biosynthetic process [Term] id: GO:0045367 name: negative regulation of interleukin-13 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] synonym: "down regulation of interleukin-13 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-13 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-13 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-13 biosynthetic process" NARROW [] synonym: "negative regulation of IL-13 biosynthesis" EXACT [] synonym: "negative regulation of IL-13 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-13 anabolism" EXACT [] synonym: "negative regulation of interleukin-13 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-13 formation" EXACT [] synonym: "negative regulation of interleukin-13 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process relationship: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process [Term] id: GO:0045368 name: positive regulation of interleukin-13 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] synonym: "activation of interleukin-13 biosynthetic process" NARROW [] synonym: "positive regulation of IL-13 biosynthesis" EXACT [] synonym: "positive regulation of IL-13 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-13 anabolism" EXACT [] synonym: "positive regulation of interleukin-13 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-13 formation" EXACT [] synonym: "positive regulation of interleukin-13 synthesis" EXACT [] synonym: "stimulation of interleukin-13 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-13 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-13 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-13 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process relationship: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process [Term] id: GO:0045369 name: regulation of interleukin-14 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] synonym: "regulation of IL-14 biosynthesis" EXACT [] synonym: "regulation of IL-14 biosynthetic process" EXACT [] synonym: "regulation of interleukin-14 anabolism" EXACT [] synonym: "regulation of interleukin-14 biosynthesis" EXACT [] synonym: "regulation of interleukin-14 formation" EXACT [] synonym: "regulation of interleukin-14 synthesis" EXACT [] is_a: GO:0032657 ! regulation of interleukin-14 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042232 ! interleukin-14 biosynthetic process [Term] id: GO:0045370 name: negative regulation of interleukin-14 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] synonym: "down regulation of interleukin-14 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-14 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-14 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-14 biosynthetic process" NARROW [] synonym: "negative regulation of IL-14 biosynthesis" EXACT [] synonym: "negative regulation of IL-14 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-14 anabolism" EXACT [] synonym: "negative regulation of interleukin-14 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-14 formation" EXACT [] synonym: "negative regulation of interleukin-14 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process relationship: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process [Term] id: GO:0045371 name: positive regulation of interleukin-14 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] synonym: "activation of interleukin-14 biosynthetic process" NARROW [] synonym: "positive regulation of IL-14 biosynthesis" EXACT [] synonym: "positive regulation of IL-14 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-14 anabolism" EXACT [] synonym: "positive regulation of interleukin-14 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-14 formation" EXACT [] synonym: "positive regulation of interleukin-14 synthesis" EXACT [] synonym: "stimulation of interleukin-14 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-14 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-14 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-14 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process relationship: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process [Term] id: GO:0045372 name: regulation of interleukin-15 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] synonym: "regulation of IL-15 biosynthesis" EXACT [] synonym: "regulation of IL-15 biosynthetic process" EXACT [] synonym: "regulation of interleukin-15 anabolism" EXACT [] synonym: "regulation of interleukin-15 biosynthesis" EXACT [] synonym: "regulation of interleukin-15 formation" EXACT [] synonym: "regulation of interleukin-15 synthesis" EXACT [] is_a: GO:0032658 ! regulation of interleukin-15 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042233 ! interleukin-15 biosynthetic process [Term] id: GO:0045373 name: negative regulation of interleukin-15 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] synonym: "down regulation of interleukin-15 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-15 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-15 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-15 biosynthetic process" NARROW [] synonym: "negative regulation of IL-15 biosynthesis" EXACT [] synonym: "negative regulation of IL-15 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-15 anabolism" EXACT [] synonym: "negative regulation of interleukin-15 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-15 formation" EXACT [] synonym: "negative regulation of interleukin-15 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process relationship: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process [Term] id: GO:0045374 name: positive regulation of interleukin-15 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] synonym: "activation of interleukin-15 biosynthetic process" NARROW [] synonym: "positive regulation of IL-15 biosynthesis" EXACT [] synonym: "positive regulation of IL-15 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-15 anabolism" EXACT [] synonym: "positive regulation of interleukin-15 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-15 formation" EXACT [] synonym: "positive regulation of interleukin-15 synthesis" EXACT [] synonym: "stimulation of interleukin-15 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-15 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-15 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-15 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process relationship: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process [Term] id: GO:0045375 name: regulation of interleukin-16 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] synonym: "regulation of IL-16 biosynthesis" EXACT [] synonym: "regulation of IL-16 biosynthetic process" EXACT [] synonym: "regulation of interleukin-16 anabolism" EXACT [] synonym: "regulation of interleukin-16 biosynthesis" EXACT [] synonym: "regulation of interleukin-16 formation" EXACT [] synonym: "regulation of interleukin-16 synthesis" EXACT [] is_a: GO:0032659 ! regulation of interleukin-16 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042234 ! interleukin-16 biosynthetic process [Term] id: GO:0045376 name: negative regulation of interleukin-16 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] synonym: "down regulation of interleukin-16 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-16 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-16 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-16 biosynthetic process" NARROW [] synonym: "negative regulation of IL-16 biosynthesis" EXACT [] synonym: "negative regulation of IL-16 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-16 anabolism" EXACT [] synonym: "negative regulation of interleukin-16 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-16 formation" EXACT [] synonym: "negative regulation of interleukin-16 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process relationship: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process [Term] id: GO:0045377 name: positive regulation of interleukin-16 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] synonym: "activation of interleukin-16 biosynthetic process" NARROW [] synonym: "positive regulation of IL-16 biosynthesis" EXACT [] synonym: "positive regulation of IL-16 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-16 anabolism" EXACT [] synonym: "positive regulation of interleukin-16 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-16 formation" EXACT [] synonym: "positive regulation of interleukin-16 synthesis" EXACT [] synonym: "stimulation of interleukin-16 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-16 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-16 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-16 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process relationship: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process [Term] id: GO:0045378 name: regulation of interleukin-17 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators] synonym: "regulation of IL-17 biosynthesis" EXACT [] synonym: "regulation of IL-17 biosynthetic process" EXACT [] synonym: "regulation of interleukin-17 anabolism" EXACT [] synonym: "regulation of interleukin-17 biosynthesis" EXACT [] synonym: "regulation of interleukin-17 formation" EXACT [] synonym: "regulation of interleukin-17 synthesis" EXACT [] is_a: GO:0032660 ! regulation of interleukin-17 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042235 ! interleukin-17 biosynthetic process [Term] id: GO:0045379 name: negative regulation of interleukin-17 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators] synonym: "down regulation of interleukin-17 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-17 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-17 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-17 biosynthetic process" NARROW [] synonym: "negative regulation of IL-17 biosynthesis" EXACT [] synonym: "negative regulation of IL-17 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-17 anabolism" EXACT [] synonym: "negative regulation of interleukin-17 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-17 formation" EXACT [] synonym: "negative regulation of interleukin-17 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process relationship: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process [Term] id: GO:0045380 name: positive regulation of interleukin-17 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators] synonym: "activation of interleukin-17 biosynthetic process" NARROW [] synonym: "positive regulation of IL-17 biosynthesis" EXACT [] synonym: "positive regulation of IL-17 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-17 anabolism" EXACT [] synonym: "positive regulation of interleukin-17 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-17 formation" EXACT [] synonym: "positive regulation of interleukin-17 synthesis" EXACT [] synonym: "stimulation of interleukin-17 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-17 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-17 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-17 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process relationship: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process [Term] id: GO:0045381 name: regulation of interleukin-18 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] synonym: "regulation of IL-18 biosynthesis" EXACT [] synonym: "regulation of IL-18 biosynthetic process" EXACT [] synonym: "regulation of interleukin-18 anabolism" EXACT [] synonym: "regulation of interleukin-18 biosynthesis" EXACT [] synonym: "regulation of interleukin-18 formation" EXACT [] synonym: "regulation of interleukin-18 synthesis" EXACT [] is_a: GO:0032661 ! regulation of interleukin-18 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042241 ! interleukin-18 biosynthetic process [Term] id: GO:0045382 name: negative regulation of interleukin-18 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] synonym: "down regulation of interleukin-18 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-18 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-18 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-18 biosynthetic process" NARROW [] synonym: "negative regulation of IL-18 biosynthesis" EXACT [] synonym: "negative regulation of IL-18 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-18 anabolism" EXACT [] synonym: "negative regulation of interleukin-18 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-18 formation" EXACT [] synonym: "negative regulation of interleukin-18 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process relationship: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process [Term] id: GO:0045383 name: positive regulation of interleukin-18 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] synonym: "activation of interleukin-18 biosynthetic process" NARROW [] synonym: "positive regulation of IL-18 biosynthesis" EXACT [] synonym: "positive regulation of IL-18 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-18 anabolism" EXACT [] synonym: "positive regulation of interleukin-18 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-18 formation" EXACT [] synonym: "positive regulation of interleukin-18 synthesis" EXACT [] synonym: "stimulation of interleukin-18 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-18 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-18 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-18 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process relationship: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process [Term] id: GO:0045384 name: regulation of interleukin-19 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] synonym: "regulation of IL-19 biosynthesis" EXACT [] synonym: "regulation of IL-19 biosynthetic process" EXACT [] synonym: "regulation of interleukin-19 anabolism" EXACT [] synonym: "regulation of interleukin-19 biosynthesis" EXACT [] synonym: "regulation of interleukin-19 formation" EXACT [] synonym: "regulation of interleukin-19 synthesis" EXACT [] is_a: GO:0032662 ! regulation of interleukin-19 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042236 ! interleukin-19 biosynthetic process [Term] id: GO:0045385 name: negative regulation of interleukin-19 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] synonym: "down regulation of interleukin-19 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-19 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-19 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-19 biosynthetic process" NARROW [] synonym: "negative regulation of IL-19 biosynthesis" EXACT [] synonym: "negative regulation of IL-19 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-19 anabolism" EXACT [] synonym: "negative regulation of interleukin-19 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-19 formation" EXACT [] synonym: "negative regulation of interleukin-19 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process relationship: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process [Term] id: GO:0045386 name: positive regulation of interleukin-19 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] synonym: "activation of interleukin-19 biosynthetic process" NARROW [] synonym: "positive regulation of IL-19 biosynthesis" EXACT [] synonym: "positive regulation of IL-19 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-19 anabolism" EXACT [] synonym: "positive regulation of interleukin-19 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-19 formation" EXACT [] synonym: "positive regulation of interleukin-19 synthesis" EXACT [] synonym: "stimulation of interleukin-19 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-19 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-19 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-19 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process relationship: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process [Term] id: GO:0045387 name: regulation of interleukin-20 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] synonym: "regulation of IL-20 biosynthesis" EXACT [] synonym: "regulation of IL-20 biosynthetic process" EXACT [] synonym: "regulation of interleukin-20 anabolism" EXACT [] synonym: "regulation of interleukin-20 biosynthesis" EXACT [] synonym: "regulation of interleukin-20 formation" EXACT [] synonym: "regulation of interleukin-20 synthesis" EXACT [] is_a: GO:0032664 ! regulation of interleukin-20 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042237 ! interleukin-20 biosynthetic process [Term] id: GO:0045388 name: negative regulation of interleukin-20 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] synonym: "down regulation of interleukin-20 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-20 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-20 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-20 biosynthetic process" NARROW [] synonym: "negative regulation of IL-20 biosynthesis" EXACT [] synonym: "negative regulation of IL-20 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-20 anabolism" EXACT [] synonym: "negative regulation of interleukin-20 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-20 formation" EXACT [] synonym: "negative regulation of interleukin-20 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process relationship: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process [Term] id: GO:0045389 name: positive regulation of interleukin-20 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] synonym: "activation of interleukin-20 biosynthetic process" NARROW [] synonym: "positive regulation of IL-20 biosynthesis" EXACT [] synonym: "positive regulation of IL-20 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-20 anabolism" EXACT [] synonym: "positive regulation of interleukin-20 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-20 formation" EXACT [] synonym: "positive regulation of interleukin-20 synthesis" EXACT [] synonym: "stimulation of interleukin-20 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-20 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-20 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-20 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process relationship: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process [Term] id: GO:0045390 name: regulation of interleukin-21 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] synonym: "regulation of IL-21 biosynthesis" EXACT [] synonym: "regulation of IL-21 biosynthetic process" EXACT [] synonym: "regulation of interleukin-21 anabolism" EXACT [] synonym: "regulation of interleukin-21 biosynthesis" EXACT [] synonym: "regulation of interleukin-21 formation" EXACT [] synonym: "regulation of interleukin-21 synthesis" EXACT [] is_a: GO:0032665 ! regulation of interleukin-21 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042238 ! interleukin-21 biosynthetic process [Term] id: GO:0045391 name: negative regulation of interleukin-21 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] synonym: "down regulation of interleukin-21 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-21 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-21 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-21 biosynthetic process" NARROW [] synonym: "negative regulation of IL-21 biosynthesis" EXACT [] synonym: "negative regulation of IL-21 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-21 anabolism" EXACT [] synonym: "negative regulation of interleukin-21 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-21 formation" EXACT [] synonym: "negative regulation of interleukin-21 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process relationship: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process [Term] id: GO:0045392 name: positive regulation of interleukin-21 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] synonym: "activation of interleukin-21 biosynthetic process" NARROW [] synonym: "positive regulation of IL-21 biosynthesis" EXACT [] synonym: "positive regulation of IL-21 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-21 anabolism" EXACT [] synonym: "positive regulation of interleukin-21 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-21 formation" EXACT [] synonym: "positive regulation of interleukin-21 synthesis" EXACT [] synonym: "stimulation of interleukin-21 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-21 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-21 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-21 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process relationship: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process [Term] id: GO:0045393 name: regulation of interleukin-22 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] synonym: "regulation of IL-22 biosynthesis" EXACT [] synonym: "regulation of IL-22 biosynthetic process" EXACT [] synonym: "regulation of interleukin-22 anabolism" EXACT [] synonym: "regulation of interleukin-22 biosynthesis" EXACT [] synonym: "regulation of interleukin-22 formation" EXACT [] synonym: "regulation of interleukin-22 synthesis" EXACT [] is_a: GO:0032666 ! regulation of interleukin-22 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042239 ! interleukin-22 biosynthetic process [Term] id: GO:0045394 name: negative regulation of interleukin-22 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] synonym: "down regulation of interleukin-22 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-22 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-22 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-22 biosynthetic process" NARROW [] synonym: "negative regulation of IL-22 biosynthesis" EXACT [] synonym: "negative regulation of IL-22 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-22 anabolism" EXACT [] synonym: "negative regulation of interleukin-22 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-22 formation" EXACT [] synonym: "negative regulation of interleukin-22 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process relationship: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process [Term] id: GO:0045395 name: positive regulation of interleukin-22 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] synonym: "activation of interleukin-22 biosynthetic process" NARROW [] synonym: "positive regulation of IL-22 biosynthesis" EXACT [] synonym: "positive regulation of IL-22 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-22 anabolism" EXACT [] synonym: "positive regulation of interleukin-22 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-22 formation" EXACT [] synonym: "positive regulation of interleukin-22 synthesis" EXACT [] synonym: "stimulation of interleukin-22 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-22 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-22 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-22 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process relationship: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process [Term] id: GO:0045396 name: regulation of interleukin-23 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] synonym: "regulation of IL-23 biosynthesis" EXACT [] synonym: "regulation of IL-23 biosynthetic process" EXACT [] synonym: "regulation of interleukin-23 anabolism" EXACT [] synonym: "regulation of interleukin-23 biosynthesis" EXACT [] synonym: "regulation of interleukin-23 formation" EXACT [] synonym: "regulation of interleukin-23 synthesis" EXACT [] is_a: GO:0032667 ! regulation of interleukin-23 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042240 ! interleukin-23 biosynthetic process [Term] id: GO:0045397 name: negative regulation of interleukin-23 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] synonym: "down regulation of interleukin-23 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-23 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-23 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-23 biosynthetic process" NARROW [] synonym: "negative regulation of IL-23 biosynthesis" EXACT [] synonym: "negative regulation of IL-23 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-23 anabolism" EXACT [] synonym: "negative regulation of interleukin-23 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-23 formation" EXACT [] synonym: "negative regulation of interleukin-23 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process relationship: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process [Term] id: GO:0045398 name: positive regulation of interleukin-23 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] synonym: "activation of interleukin-23 biosynthetic process" NARROW [] synonym: "positive regulation of IL-23 biosynthesis" EXACT [] synonym: "positive regulation of IL-23 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-23 anabolism" EXACT [] synonym: "positive regulation of interleukin-23 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-23 formation" EXACT [] synonym: "positive regulation of interleukin-23 synthesis" EXACT [] synonym: "stimulation of interleukin-23 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-23 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-23 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-23 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process relationship: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process [Term] id: GO:0045399 name: regulation of interleukin-3 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] synonym: "regulation of IL-3 biosynthesis" EXACT [] synonym: "regulation of IL-3 biosynthetic process" EXACT [] synonym: "regulation of interleukin-3 anabolism" EXACT [] synonym: "regulation of interleukin-3 biosynthesis" EXACT [] synonym: "regulation of interleukin-3 formation" EXACT [] synonym: "regulation of interleukin-3 synthesis" EXACT [] is_a: GO:0032672 ! regulation of interleukin-3 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042223 ! interleukin-3 biosynthetic process [Term] id: GO:0045400 name: negative regulation of interleukin-3 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] synonym: "down regulation of interleukin-3 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-3 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-3 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-3 biosynthetic process" NARROW [] synonym: "negative regulation of IL-3 biosynthesis" EXACT [] synonym: "negative regulation of IL-3 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-3 anabolism" EXACT [] synonym: "negative regulation of interleukin-3 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-3 formation" EXACT [] synonym: "negative regulation of interleukin-3 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process relationship: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process [Term] id: GO:0045401 name: positive regulation of interleukin-3 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] synonym: "activation of interleukin-3 biosynthetic process" NARROW [] synonym: "positive regulation of IL-3 biosynthesis" EXACT [] synonym: "positive regulation of IL-3 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-3 anabolism" EXACT [] synonym: "positive regulation of interleukin-3 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-3 formation" EXACT [] synonym: "positive regulation of interleukin-3 synthesis" EXACT [] synonym: "stimulation of interleukin-3 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-3 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-3 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-3 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process relationship: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process [Term] id: GO:0045402 name: regulation of interleukin-4 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] synonym: "regulation of IL-4 biosynthesis" EXACT [] synonym: "regulation of IL-4 biosynthetic process" EXACT [] synonym: "regulation of interleukin-4 anabolism" EXACT [] synonym: "regulation of interleukin-4 biosynthesis" EXACT [] synonym: "regulation of interleukin-4 formation" EXACT [] synonym: "regulation of interleukin-4 synthesis" EXACT [] is_a: GO:0032673 ! regulation of interleukin-4 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042097 ! interleukin-4 biosynthetic process [Term] id: GO:0045403 name: negative regulation of interleukin-4 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] synonym: "down regulation of interleukin-4 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-4 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-4 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-4 biosynthetic process" NARROW [] synonym: "negative regulation of IL-4 biosynthesis" EXACT [] synonym: "negative regulation of IL-4 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-4 anabolism" EXACT [] synonym: "negative regulation of interleukin-4 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-4 formation" EXACT [] synonym: "negative regulation of interleukin-4 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process relationship: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process [Term] id: GO:0045404 name: positive regulation of interleukin-4 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] synonym: "activation of interleukin-4 biosynthetic process" NARROW [] synonym: "positive regulation of IL-4 biosynthesis" EXACT [] synonym: "positive regulation of IL-4 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-4 anabolism" EXACT [] synonym: "positive regulation of interleukin-4 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-4 formation" EXACT [] synonym: "positive regulation of interleukin-4 synthesis" EXACT [] synonym: "stimulation of interleukin-4 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-4 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-4 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-4 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process relationship: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process [Term] id: GO:0045405 name: regulation of interleukin-5 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] synonym: "regulation of IL-5 biosynthesis" EXACT [] synonym: "regulation of IL-5 biosynthetic process" EXACT [] synonym: "regulation of interleukin-5 anabolism" EXACT [] synonym: "regulation of interleukin-5 biosynthesis" EXACT [] synonym: "regulation of interleukin-5 formation" EXACT [] synonym: "regulation of interleukin-5 synthesis" EXACT [] is_a: GO:0032674 ! regulation of interleukin-5 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042225 ! interleukin-5 biosynthetic process [Term] id: GO:0045406 name: negative regulation of interleukin-5 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] synonym: "down regulation of interleukin-5 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-5 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-5 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-5 biosynthetic process" NARROW [] synonym: "negative regulation of IL-5 biosynthesis" EXACT [] synonym: "negative regulation of IL-5 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-5 anabolism" EXACT [] synonym: "negative regulation of interleukin-5 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-5 formation" EXACT [] synonym: "negative regulation of interleukin-5 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process relationship: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process [Term] id: GO:0045407 name: positive regulation of interleukin-5 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] synonym: "activation of interleukin-5 biosynthetic process" NARROW [] synonym: "positive regulation of IL-5 biosynthesis" EXACT [] synonym: "positive regulation of IL-5 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-5 anabolism" EXACT [] synonym: "positive regulation of interleukin-5 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-5 formation" EXACT [] synonym: "positive regulation of interleukin-5 synthesis" EXACT [] synonym: "stimulation of interleukin-5 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-5 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-5 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-5 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process relationship: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process [Term] id: GO:0045408 name: regulation of interleukin-6 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] synonym: "regulation of IL-6 biosynthesis" EXACT [] synonym: "regulation of IL-6 biosynthetic process" EXACT [] synonym: "regulation of interleukin-6 anabolism" EXACT [] synonym: "regulation of interleukin-6 biosynthesis" EXACT [] synonym: "regulation of interleukin-6 formation" EXACT [] synonym: "regulation of interleukin-6 synthesis" EXACT [] is_a: GO:0032675 ! regulation of interleukin-6 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042226 ! interleukin-6 biosynthetic process [Term] id: GO:0045409 name: negative regulation of interleukin-6 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] synonym: "down regulation of interleukin-6 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-6 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-6 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-6 biosynthetic process" NARROW [] synonym: "negative regulation of IL-6 biosynthesis" EXACT [] synonym: "negative regulation of IL-6 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-6 anabolism" EXACT [] synonym: "negative regulation of interleukin-6 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-6 formation" EXACT [] synonym: "negative regulation of interleukin-6 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process relationship: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process [Term] id: GO:0045410 name: positive regulation of interleukin-6 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] synonym: "activation of interleukin-6 biosynthetic process" NARROW [] synonym: "positive regulation of IL-6 biosynthesis" EXACT [] synonym: "positive regulation of IL-6 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-6 anabolism" EXACT [] synonym: "positive regulation of interleukin-6 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-6 formation" EXACT [] synonym: "positive regulation of interleukin-6 synthesis" EXACT [] synonym: "stimulation of interleukin-6 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-6 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-6 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-6 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process relationship: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process [Term] id: GO:0045411 name: regulation of interleukin-7 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] synonym: "regulation of IL-7 biosynthesis" EXACT [] synonym: "regulation of IL-7 biosynthetic process" EXACT [] synonym: "regulation of interleukin-7 anabolism" EXACT [] synonym: "regulation of interleukin-7 biosynthesis" EXACT [] synonym: "regulation of interleukin-7 formation" EXACT [] synonym: "regulation of interleukin-7 synthesis" EXACT [] is_a: GO:0032676 ! regulation of interleukin-7 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042227 ! interleukin-7 biosynthetic process [Term] id: GO:0045412 name: negative regulation of interleukin-7 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] synonym: "down regulation of interleukin-7 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-7 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-7 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-7 biosynthetic process" NARROW [] synonym: "negative regulation of IL-7 biosynthesis" EXACT [] synonym: "negative regulation of IL-7 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-7 anabolism" EXACT [] synonym: "negative regulation of interleukin-7 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-7 formation" EXACT [] synonym: "negative regulation of interleukin-7 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process relationship: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process [Term] id: GO:0045413 name: positive regulation of interleukin-7 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] synonym: "activation of interleukin-7 biosynthetic process" NARROW [] synonym: "positive regulation of IL-7 biosynthesis" EXACT [] synonym: "positive regulation of IL-7 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-7 anabolism" EXACT [] synonym: "positive regulation of interleukin-7 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-7 formation" EXACT [] synonym: "positive regulation of interleukin-7 synthesis" EXACT [] synonym: "stimulation of interleukin-7 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-7 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-7 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-7 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process relationship: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process [Term] id: GO:0045414 name: regulation of interleukin-8 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] synonym: "regulation of IL-8 biosynthesis" EXACT [] synonym: "regulation of IL-8 biosynthetic process" EXACT [] synonym: "regulation of interleukin-8 anabolism" EXACT [] synonym: "regulation of interleukin-8 biosynthesis" EXACT [] synonym: "regulation of interleukin-8 formation" EXACT [] synonym: "regulation of interleukin-8 synthesis" EXACT [] is_a: GO:0032677 ! regulation of interleukin-8 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042228 ! interleukin-8 biosynthetic process [Term] id: GO:0045415 name: negative regulation of interleukin-8 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] synonym: "down regulation of interleukin-8 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-8 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-8 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-8 biosynthetic process" NARROW [] synonym: "negative regulation of IL-8 biosynthesis" EXACT [] synonym: "negative regulation of IL-8 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-8 anabolism" EXACT [] synonym: "negative regulation of interleukin-8 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-8 formation" EXACT [] synonym: "negative regulation of interleukin-8 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process relationship: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process [Term] id: GO:0045416 name: positive regulation of interleukin-8 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] synonym: "activation of interleukin-8 biosynthetic process" NARROW [] synonym: "positive regulation of IL-8 biosynthesis" EXACT [] synonym: "positive regulation of IL-8 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-8 anabolism" EXACT [] synonym: "positive regulation of interleukin-8 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-8 formation" EXACT [] synonym: "positive regulation of interleukin-8 synthesis" EXACT [] synonym: "stimulation of interleukin-8 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-8 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-8 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-8 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process relationship: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process [Term] id: GO:0045417 name: regulation of interleukin-9 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] synonym: "regulation of IL-9 biosynthesis" EXACT [] synonym: "regulation of IL-9 biosynthetic process" EXACT [] synonym: "regulation of interleukin-9 anabolism" EXACT [] synonym: "regulation of interleukin-9 biosynthesis" EXACT [] synonym: "regulation of interleukin-9 formation" EXACT [] synonym: "regulation of interleukin-9 synthesis" EXACT [] is_a: GO:0032678 ! regulation of interleukin-9 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042229 ! interleukin-9 biosynthetic process [Term] id: GO:0045418 name: negative regulation of interleukin-9 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] synonym: "down regulation of interleukin-9 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-9 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-9 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-9 biosynthetic process" NARROW [] synonym: "negative regulation of IL-9 biosynthesis" EXACT [] synonym: "negative regulation of IL-9 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-9 anabolism" EXACT [] synonym: "negative regulation of interleukin-9 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-9 formation" EXACT [] synonym: "negative regulation of interleukin-9 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process relationship: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process [Term] id: GO:0045419 name: positive regulation of interleukin-9 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] synonym: "activation of interleukin-9 biosynthetic process" NARROW [] synonym: "positive regulation of IL-9 biosynthesis" EXACT [] synonym: "positive regulation of IL-9 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-9 anabolism" EXACT [] synonym: "positive regulation of interleukin-9 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-9 formation" EXACT [] synonym: "positive regulation of interleukin-9 synthesis" EXACT [] synonym: "stimulation of interleukin-9 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-9 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-9 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-9 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process relationship: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process [Term] id: GO:0045420 name: regulation of connective tissue growth factor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] synonym: "regulation of connective tissue growth factor anabolism" EXACT [] synonym: "regulation of connective tissue growth factor biosynthesis" EXACT [] synonym: "regulation of connective tissue growth factor formation" EXACT [] synonym: "regulation of connective tissue growth factor synthesis" EXACT [] is_a: GO:0032643 ! regulation of connective tissue growth factor production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0045189 ! connective tissue growth factor biosynthetic process [Term] id: GO:0045421 name: negative regulation of connective tissue growth factor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] synonym: "down regulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "down-regulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "downregulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "inhibition of connective tissue growth factor biosynthetic process" NARROW [] synonym: "negative regulation of connective tissue growth factor anabolism" EXACT [] synonym: "negative regulation of connective tissue growth factor biosynthesis" EXACT [] synonym: "negative regulation of connective tissue growth factor formation" EXACT [] synonym: "negative regulation of connective tissue growth factor synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process relationship: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process [Term] id: GO:0045422 name: positive regulation of connective tissue growth factor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] synonym: "activation of connective tissue growth factor biosynthetic process" NARROW [] synonym: "positive regulation of connective tissue growth factor anabolism" EXACT [] synonym: "positive regulation of connective tissue growth factor biosynthesis" EXACT [] synonym: "positive regulation of connective tissue growth factor formation" EXACT [] synonym: "positive regulation of connective tissue growth factor synthesis" EXACT [] synonym: "stimulation of connective tissue growth factor biosynthetic process" NARROW [] synonym: "up regulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "up-regulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "upregulation of connective tissue growth factor biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process relationship: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process [Term] id: GO:0045423 name: regulation of granulocyte macrophage colony-stimulating factor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators] synonym: "regulation of granulocyte macrophage colony stimulating factor biosynthetic process" EXACT [] synonym: "regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT [] synonym: "regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] synonym: "regulation of granulocyte macrophage colony-stimulating factor formation" EXACT [] synonym: "regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT [] is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process [Term] id: GO:0045424 name: negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators] synonym: "down regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "down-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "downregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "inhibition of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] synonym: "negative regulation of granulocyte macrophage colony stimulating factor biosynthetic process" EXACT [] synonym: "negative regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT [] synonym: "negative regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] synonym: "negative regulation of granulocyte macrophage colony-stimulating factor formation" EXACT [] synonym: "negative regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process relationship: negatively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process [Term] id: GO:0045425 name: positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators] synonym: "activation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] synonym: "positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process" EXACT [] synonym: "positive regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT [] synonym: "positive regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] synonym: "positive regulation of granulocyte macrophage colony-stimulating factor formation" EXACT [] synonym: "positive regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT [] synonym: "stimulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] synonym: "up regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "up-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "upregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process relationship: positively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process [Term] id: GO:0045426 name: quinone cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any quinone cofactor, such as menaquinone (vitamin K2), ubiquinone (coenzyme Q) or phylloquinone (vitamin K1)." [GOC:mb] subset: gosubset_prok synonym: "quinone cofactor anabolism" EXACT [] synonym: "quinone cofactor biosynthesis" EXACT [] synonym: "quinone cofactor formation" EXACT [] synonym: "quinone cofactor synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042375 ! quinone cofactor metabolic process [Term] id: GO:0045427 name: enzyme active site formation via (phospho-5'-guanosine)-L-histidine namespace: biological_process def: "The transient guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325] subset: gosubset_prok xref: RESID:AA0325 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0045428 name: regulation of nitric oxide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] synonym: "regulation of nitric oxide anabolism" EXACT [] synonym: "regulation of nitric oxide biosynthesis" EXACT [] synonym: "regulation of nitric oxide formation" EXACT [] synonym: "regulation of nitric oxide synthesis" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: regulates GO:0006809 ! nitric oxide biosynthetic process [Term] id: GO:0045429 name: positive regulation of nitric oxide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] synonym: "activation of nitric oxide biosynthetic process" NARROW [] synonym: "positive regulation of nitric oxide anabolism" EXACT [] synonym: "positive regulation of nitric oxide biosynthesis" EXACT [] synonym: "positive regulation of nitric oxide formation" EXACT [] synonym: "positive regulation of nitric oxide synthesis" EXACT [] synonym: "stimulation of nitric oxide biosynthetic process" NARROW [] synonym: "up regulation of nitric oxide biosynthetic process" EXACT [] synonym: "up-regulation of nitric oxide biosynthetic process" EXACT [] synonym: "upregulation of nitric oxide biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process relationship: positively_regulates GO:0006809 ! nitric oxide biosynthetic process [Term] id: GO:0045430 name: chalcone isomerase activity namespace: molecular_function def: "Catalysis of the reaction: a chalcone = a flavanone." [EC:5.5.1.6] synonym: "chalcone--flavonone isomerase activity" EXACT [EC:5.5.1.6] synonym: "chalcone-flavanone isomerase activity" EXACT [] synonym: "flavanone lyase (decyclizing)" EXACT [EC:5.5.1.6] xref: EC:5.5.1.6 xref: MetaCyc:CHALCONE-ISOMERASE-RXN is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0045431 name: flavonol synthase activity namespace: molecular_function def: "Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O." [EC:1.14.11.23, ISBN:0943088372, PMID:7904213] synonym: "dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.23] synonym: "flavonoid 2-oxoglutarate-dependent dioxygenase activity" EXACT [EC:1.14.11.23] synonym: "FLS activity" RELATED [EC:1.14.11.23] xref: EC:1.14.11.23 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0045433 name: male courtship behavior, veined wing generated song production namespace: biological_process def: "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, song production" BROAD [] synonym: "male courtship behaviour, song production" BROAD [] synonym: "male courtship behaviour, veined wing generated song production" EXACT [] is_a: GO:0008049 ! male courtship behavior relationship: part_of GO:0016545 ! male courtship behavior, veined wing vibration [Term] id: GO:0045434 name: negative regulation of female receptivity, post-mating namespace: biological_process def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827] synonym: "down regulation of female receptivity, post-mating" EXACT [] synonym: "down-regulation of female receptivity, post-mating" EXACT [] synonym: "downregulation of female receptivity, post-mating" EXACT [] synonym: "inhibition of female receptivity, post-mating" NARROW [] is_a: GO:0007621 ! negative regulation of female receptivity is_a: GO:0046008 ! regulation of female receptivity, post-mating [Term] id: GO:0045435 name: lycopene epsilon cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)." [PMID:8837512] synonym: "lycopene cyclase" BROAD [] is_a: GO:0009975 ! cyclase activity is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0045436 name: lycopene beta cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively." [PMID:8837512] subset: gosubset_prok synonym: "crtL" RELATED [] synonym: "lycopene cyclase" BROAD [] xref: MetaCyc:RXN1F-150 is_a: GO:0009975 ! cyclase activity is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0045437 name: uridine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + uridine = ribofuranose + uracil." [EC:3.2.2.3, RHEA:15580] subset: gosubset_prok synonym: "uridine hydrolase activity" EXACT [] synonym: "uridine ribohydrolase activity" EXACT [EC:3.2.2.3] xref: EC:3.2.2.3 xref: KEGG:R01080 xref: MetaCyc:URIDINE-NUCLEOSIDASE-RXN xref: RHEA:15580 is_a: GO:0050263 ! ribosylpyrimidine nucleosidase activity [Term] id: GO:0045438 name: delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity namespace: molecular_function def: "Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol." [PMID:1572368, PMID:2061333] synonym: "ACV synthetase activity" BROAD [] is_a: GO:0016874 ! ligase activity [Term] id: GO:0045439 name: isopenicillin-N epimerase activity namespace: molecular_function def: "Catalysis of the reaction: isopenicillin N = penicillin N." [EC:5.1.1.17, RHEA:20036] subset: gosubset_prok synonym: "isopenicillin N epimerase activity" EXACT [] synonym: "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity" EXACT [EC:5.1.1.17] xref: EC:5.1.1.17 xref: KEGG:R04147 xref: MetaCyc:5.1.1.17-RXN xref: RHEA:20036 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0045442 name: deacetoxycephalosporin-C hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O(2) = CO(2) + deacetylcephalosporin C + succinate." [EC:1.14.11.26, RHEA:16808] synonym: "3'-methylcephem hydroxylase activity" EXACT [EC:1.14.11.26] synonym: "beta-lactam hydroxylase activity" EXACT [] synonym: "DACS" RELATED [EC:1.14.11.26] synonym: "DAOC hydroxylase activity" EXACT [EC:1.14.11.26] synonym: "deacetoxycephalosporin C hydroxylase activity" EXACT [EC:1.14.11.26] synonym: "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.26] synonym: "deacetylcephalosporin C synthase activity" EXACT [EC:1.14.11.26] xref: EC:1.14.11.26 xref: KEGG:R05229 xref: MetaCyc:1.14.11.26-RXN xref: RHEA:16808 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0045443 name: juvenile hormone secretion namespace: biological_process def: "The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0045444 name: fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] synonym: "adipocyte cell differentiation" EXACT [] synonym: "adipocyte differentiation" EXACT [] synonym: "adipogenesis" RELATED [] synonym: "adipose cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0045445 name: myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "myoblast cell differentiation" EXACT [] is_a: GO:0042692 ! muscle cell differentiation [Term] id: GO:0045446 name: endothelial cell differentiation namespace: biological_process def: "The process in which a mesodermal angioblast acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0003158 ! endothelium development [Term] id: GO:0045448 name: mitotic cell cycle, embryonic namespace: biological_process def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators] is_a: GO:0000278 ! mitotic cell cycle relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0045450 name: bicoid mRNA localization namespace: biological_process def: "Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators] synonym: "bicoid mRNA localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of bicoid mRNA localization" EXACT [] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification [Term] id: GO:0045451 name: pole plasm oskar mRNA localization namespace: biological_process def: "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] synonym: "establishment and maintenance of oskar mRNA localization in pole plasm" EXACT [] synonym: "establishment and maintenance of pole plasm oskar mRNA localization" EXACT [] synonym: "oocyte pole plasm oskar mRNA localization" EXACT [] synonym: "pole plasm oskar mRNA localisation" EXACT [GOC:mah] is_a: GO:0019094 ! pole plasm mRNA localization [Term] id: GO:0045453 name: bone resorption namespace: biological_process def: "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780] xref: Wikipedia:Bone_resorption is_a: GO:0001894 ! tissue homeostasis relationship: part_of GO:0046849 ! bone remodeling [Term] id: GO:0045454 name: cell redox homeostasis namespace: biological_process alt_id: GO:0030503 alt_id: GO:0045867 alt_id: GO:0045868 def: "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "regulation of cell redox homeostasis" RELATED [] synonym: "regulation of redox homeostasis" BROAD [] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0045455 name: ecdysteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ecdysteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042180 ! cellular ketone metabolic process relationship: part_of GO:0002165 ! instar larval or pupal development [Term] id: GO:0045456 name: ecdysteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] synonym: "ecdysteroid anabolism" EXACT [] synonym: "ecdysteroid biosynthesis" EXACT [] synonym: "ecdysteroid formation" EXACT [] synonym: "ecdysteroid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0045457 name: ecdysteroid secretion namespace: biological_process def: "The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0045458 name: recombination within rDNA repeats namespace: biological_process def: "Genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term was reinstated from obsolete. subset: gosubset_prok synonym: "recombination within ribosomal DNA repeats" EXACT [] is_a: GO:0006310 ! DNA recombination is_a: GO:0043007 ! maintenance of rDNA [Term] id: GO:0045459 name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide namespace: biological_process def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide." [PMID:11592901, RESID:AA0326] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide" EXACT [] xref: RESID:AA0326 is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0045460 name: sterigmatocystin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [CHEBI:18227, GOC:go_curators] subset: gosubset_prok synonym: "sterigmatocystin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009404 ! toxin metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0045461 name: sterigmatocystin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [CHEBI:18227, GOC:go_curators] subset: gosubset_prok synonym: "sterigmatocystin anabolism" EXACT [] synonym: "sterigmatocystin biosynthesis" EXACT [] synonym: "sterigmatocystin formation" EXACT [] synonym: "sterigmatocystin synthesis" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0045460 ! sterigmatocystin metabolic process [Term] id: GO:0045462 name: trichothecene 3-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis." [PMID:10583973] is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0045463 name: R8 cell development namespace: biological_process def: "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0045465 ! R8 cell differentiation [Term] id: GO:0045464 name: R8 cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339] is_a: GO:0043704 ! photoreceptor cell fate specification relationship: part_of GO:0007460 ! R8 cell fate commitment [Term] id: GO:0045465 name: R8 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0045466 name: R7 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0045467 name: R7 cell development namespace: biological_process def: "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0045466 ! R7 cell differentiation [Term] id: GO:0045468 name: regulation of R8 cell spacing in compound eye namespace: biological_process def: "Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339] synonym: "R8 cell spacing in compound eye" RELATED [GOC:dph, GOC:tb] synonym: "regulation of R8 spacing" EXACT [GOC:dph] is_a: GO:0007389 ! pattern specification process is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0048749 ! compound eye development [Term] id: GO:0045469 name: negative regulation of R8 cell spacing in compound eye namespace: biological_process def: "Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye." [GOC:dph, GOC:tb, PMID:11880339] synonym: "down regulation of R8 spacing" EXACT [] synonym: "down-regulation of R8 spacing" EXACT [] synonym: "downregulation of R8 spacing" EXACT [] synonym: "inhibition of R8 spacing" NARROW [] is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye [Term] id: GO:0045470 name: R8 cell-mediated photoreceptor organization namespace: biological_process def: "The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor." [PMID:11880339] synonym: "R8-mediated photoreceptor organisation" EXACT [GOC:curators] is_a: GO:0003002 ! regionalization relationship: part_of GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0045471 name: response to ethanol namespace: biological_process alt_id: GO:0017036 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0045472 name: response to ether namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0045473 name: response to ethanol (sensu Insecta) namespace: biological_process def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. is_obsolete: true consider: GO:0048149 [Term] id: GO:0045474 name: response to ether (sensu Insecta) namespace: biological_process def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. is_obsolete: true consider: GO:0048150 [Term] id: GO:0045475 name: locomotor rhythm namespace: biological_process def: "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] synonym: "circadian locomotor activity rhythm" NARROW [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0048512 ! circadian behavior [Term] id: GO:0045476 name: nurse cell apoptosis namespace: biological_process def: "The process in which nurse cells undergo apoptosis. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptosis." [PMID:11973306] synonym: "apoptosis of nurse cells" EXACT [] synonym: "nurse cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of nurse cells by apoptosis" EXACT [] is_a: GO:0006915 ! apoptosis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0045477 name: regulation of nurse cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nurse cell apoptosis." [PMID:11973306] is_a: GO:0042981 ! regulation of apoptosis is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0045476 ! nurse cell apoptosis [Term] id: GO:0045478 name: fusome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah] subset: goslim_pir synonym: "fusome organisation" EXACT [GOC:curators] synonym: "fusome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0045479 name: vesicle targeting to fusome namespace: biological_process def: "The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome." [PMID:9046244] synonym: "vesicle-fusome targeting" EXACT [] is_a: GO:0006903 ! vesicle targeting relationship: part_of GO:0045478 ! fusome organization [Term] id: GO:0045480 name: galactose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide." [EC:1.1.3.9] synonym: "beta-galactose oxidase activity" RELATED [EC:1.1.3.9] synonym: "D-galactose oxidase activity" EXACT [EC:1.1.3.9] synonym: "D-galactose:oxygen 6-oxidoreductase activity" EXACT [EC:1.1.3.9] xref: EC:1.1.3.9 xref: MetaCyc:GALACTOSE-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0045481 name: 6-endo-hydroxycineole dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-endo-hydroxycineole + NAD(+) = 6-oxocineole + H(+) + NADH." [EC:1.1.1.241, RHEA:11739] synonym: "6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.241] xref: EC:1.1.1.241 xref: KEGG:R02994 xref: MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN xref: RHEA:11739 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0045482 name: trichodiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene." [EC:4.2.3.6, RHEA:12055] synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.6] synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)" EXACT [EC:4.2.3.6] synonym: "trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity" EXACT [EC:4.2.3.6] synonym: "trichodiene synthetase activity" EXACT [EC:4.2.3.6] xref: EC:4.2.3.6 xref: KEGG:R02306 xref: MetaCyc:TRICHODIENE-SYNTHASE-RXN xref: RHEA:12055 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0045483 name: aristolochene synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate." [EC:4.2.3.9] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9] synonym: "5-epi-aristolochene synthase activity" EXACT [EC:4.2.3.9] synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.9] synonym: "trans,trans-farnesyl diphosphate aristolochene-lyase activity" EXACT [EC:4.2.3.9] synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9] xref: EC:4.2.3.9 xref: MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0045484 name: L-lysine 6-transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine." [EC:2.6.1.36, RHEA:21203] subset: gosubset_prok synonym: "L-lysine aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine transaminase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine-alpha-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine:2-oxoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "lysine 6-aminotransferase activity" EXACT [] synonym: "lysine epsilon-aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "lysine epsilon-transaminase activity" EXACT [EC:2.6.1.36] synonym: "lysine:2-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] xref: EC:2.6.1.36 xref: KEGG:R00457 xref: MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN xref: RHEA:21203 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0045485 name: omega-6 fatty acid desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain." [PMID:7846158] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0045486 name: naringenin 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2." [EC:1.14.11.9] synonym: "(2S)-flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3-beta-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3-dioxygenase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3beta-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone synthase I activity" EXACT [EC:1.14.11.9] synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.9] synonym: "naringenin 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.9] xref: EC:1.14.11.9 xref: MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0045487 name: gibberellin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [GOC:go_curators] subset: gosubset_prok synonym: "gibberellic acid breakdown" NARROW [] synonym: "gibberellic acid catabolic process" NARROW [] synonym: "gibberellic acid catabolism" NARROW [] synonym: "gibberellic acid degradation" NARROW [] synonym: "gibberellin catabolism" EXACT [] is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0016103 ! diterpenoid catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0045488 name: pectin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge." [GOC:tair_curators] subset: gosubset_prok synonym: "pectin metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0045489 name: pectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668] subset: gosubset_prok synonym: "pectin anabolism" EXACT [] synonym: "pectin biosynthesis" EXACT [] synonym: "pectin formation" EXACT [] synonym: "pectin synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0045488 ! pectin metabolic process [Term] id: GO:0045490 name: pectin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668] subset: gosubset_prok synonym: "pectin breakdown" EXACT [] synonym: "pectin catabolism" EXACT [] synonym: "pectin degradation" EXACT [] is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0045488 ! pectin metabolic process [Term] id: GO:0045491 name: xylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] subset: gosubset_prok synonym: "xylan metabolism" EXACT [] is_a: GO:0010410 ! hemicellulose metabolic process [Term] id: GO:0045492 name: xylan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] subset: gosubset_prok synonym: "xylan anabolism" EXACT [] synonym: "xylan biosynthesis" EXACT [] synonym: "xylan formation" EXACT [] synonym: "xylan synthesis" EXACT [] is_a: GO:0045491 ! xylan metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process [Term] id: GO:0045493 name: xylan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] subset: gosubset_prok synonym: "xylan breakdown" EXACT [] synonym: "xylan catabolism" EXACT [] synonym: "xylan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0045494 name: photoreceptor cell maintenance namespace: biological_process def: "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf] is_a: GO:0043954 ! cellular component maintenance relationship: part_of GO:0007601 ! visual perception [Term] id: GO:0045495 name: pole plasm namespace: cellular_component def: "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380] synonym: "germ plasm" NARROW [] synonym: "polar plasm" EXACT [] is_a: GO:0005737 ! cytoplasm [Term] id: GO:0045496 name: male analia development namespace: biological_process def: "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] is_a: GO:0007487 ! analia development [Term] id: GO:0045497 name: female analia development namespace: biological_process def: "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] is_a: GO:0007487 ! analia development [Term] id: GO:0045498 name: sex comb development namespace: biological_process def: "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0045499 name: chemorepellent activity namespace: molecular_function def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "chemorepellant activity" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0045500 name: sevenless signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the sevenless receptor binding to one of its physiological ligands." [GOC:bf] synonym: "sev receptor signaling pathway" EXACT [] synonym: "sev signaling pathway" EXACT [] synonym: "sevenless signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0007465 ! R7 cell fate commitment [Term] id: GO:0045501 name: regulation of sevenless signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] synonym: "regulation of sev signaling pathway" EXACT [] synonym: "regulation of sevenless signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045676 ! regulation of R7 cell differentiation relationship: regulates GO:0045500 ! sevenless signaling pathway [Term] id: GO:0045502 name: dynein binding namespace: molecular_function def: "Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0045503 name: dynein light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of the dynein complex." [GOC:bf] is_a: GO:0045502 ! dynein binding [Term] id: GO:0045504 name: dynein heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of the dynein complex." [GOC:bf] is_a: GO:0045502 ! dynein binding [Term] id: GO:0045505 name: dynein intermediate chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intermediate chain of the dynein complex." [GOC:bf] is_a: GO:0045502 ! dynein binding [Term] id: GO:0045506 name: interleukin-24 receptor activity namespace: molecular_function def: "Combining with interleukin-24 to initiate a change in cell activity." [GOC:jl] synonym: "IL-24 receptor activity" EXACT [GOC:mah] synonym: "IL-24R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0045510 ! interleukin-24 binding [Term] id: GO:0045507 name: interleukin-25 receptor activity namespace: molecular_function def: "Combining with interleukin-25 to initiate a change in cell activity." [GOC:jl] synonym: "IL-25 receptor activity" EXACT [GOC:mah] synonym: "IL-25R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0045511 ! interleukin-25 binding [Term] id: GO:0045508 name: interleukin-26 receptor activity namespace: molecular_function def: "Combining with interleukin-26 to initiate a change in cell activity." [GOC:jl] synonym: "IL-26 receptor activity" EXACT [GOC:mah] synonym: "IL-26R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0045512 ! interleukin-26 binding [Term] id: GO:0045509 name: interleukin-27 receptor activity namespace: molecular_function def: "Combining with interleukin-27 to initiate a change in cell activity." [GOC:jl] synonym: "IL-27 receptor activity" EXACT [GOC:mah] synonym: "IL-27R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0045513 ! interleukin-27 binding [Term] id: GO:0045510 name: interleukin-24 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-24." [GOC:go_curators] synonym: "IL-24 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0045511 name: interleukin-25 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-25." [GOC:go_curators] synonym: "IL-25 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0045512 name: interleukin-26 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-26." [GOC:go_curators] synonym: "IL-26 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0045513 name: interleukin-27 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-27." [GOC:go_curators] synonym: "IL-27 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0045514 name: interleukin-16 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-16 receptor." [GOC:go_curators] synonym: "IL-16" NARROW [] synonym: "interleukin-16 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045515 name: interleukin-18 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-18 receptor." [GOC:go_curators] synonym: "IL-18" NARROW [] synonym: "interleukin-18 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045516 name: interleukin-19 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-19 receptor." [GOC:go_curators] synonym: "IL-19" NARROW [] synonym: "interleukin-19 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045517 name: interleukin-20 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-20 receptor." [GOC:go_curators] synonym: "IL-20" NARROW [] synonym: "interleukin-20 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045518 name: interleukin-22 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-22 receptor." [GOC:go_curators] synonym: "IL-22" NARROW [] synonym: "interleukin-22 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045519 name: interleukin-23 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-23 receptor." [GOC:go_curators] synonym: "IL-23" NARROW [] synonym: "interleukin-23 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045520 name: interleukin-24 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-24 receptor." [GOC:go_curators] synonym: "IL-24" NARROW [] synonym: "interleukin-24 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045521 name: interleukin-25 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-25 receptor." [GOC:go_curators] synonym: "IL-25" NARROW [] synonym: "interleukin-25 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045522 name: interleukin-26 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-26 receptor." [GOC:go_curators] synonym: "IL-26" NARROW [] synonym: "interleukin-26 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045523 name: interleukin-27 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-27 receptor." [GOC:go_curators] synonym: "IL-27" NARROW [] synonym: "interleukin-27 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045524 name: interleukin-24 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] synonym: "IL-24 biosynthesis" EXACT [] synonym: "IL-24 biosynthetic process" EXACT [] synonym: "interleukin-24 anabolism" EXACT [] synonym: "interleukin-24 biosynthesis" EXACT [] synonym: "interleukin-24 formation" EXACT [] synonym: "interleukin-24 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032628 ! interleukin-24 production [Term] id: GO:0045525 name: interleukin-25 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] synonym: "IL-25 biosynthesis" EXACT [] synonym: "IL-25 biosynthetic process" EXACT [] synonym: "interleukin-25 anabolism" EXACT [] synonym: "interleukin-25 biosynthesis" EXACT [] synonym: "interleukin-25 formation" EXACT [] synonym: "interleukin-25 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032629 ! interleukin-25 production [Term] id: GO:0045526 name: interleukin-26 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] synonym: "IL-26 biosynthesis" EXACT [] synonym: "IL-26 biosynthetic process" EXACT [] synonym: "interleukin-26 anabolism" EXACT [] synonym: "interleukin-26 biosynthesis" EXACT [] synonym: "interleukin-26 formation" EXACT [] synonym: "interleukin-26 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032630 ! interleukin-26 production [Term] id: GO:0045527 name: interleukin-27 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] synonym: "IL-27 biosynthesis" EXACT [] synonym: "IL-27 biosynthetic process" EXACT [] synonym: "interleukin-27 anabolism" EXACT [] synonym: "interleukin-27 biosynthesis" EXACT [] synonym: "interleukin-27 formation" EXACT [] synonym: "interleukin-27 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032631 ! interleukin-27 production [Term] id: GO:0045528 name: regulation of interleukin-24 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] synonym: "regulation of IL-24 biosynthesis" EXACT [] synonym: "regulation of IL-24 biosynthetic process" EXACT [] synonym: "regulation of interleukin-24 anabolism" EXACT [] synonym: "regulation of interleukin-24 biosynthesis" EXACT [] synonym: "regulation of interleukin-24 formation" EXACT [] synonym: "regulation of interleukin-24 synthesis" EXACT [] is_a: GO:0032668 ! regulation of interleukin-24 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0045524 ! interleukin-24 biosynthetic process [Term] id: GO:0045529 name: regulation of interleukin-25 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] synonym: "regulation of IL-25 biosynthesis" EXACT [] synonym: "regulation of IL-25 biosynthetic process" EXACT [] synonym: "regulation of interleukin-25 anabolism" EXACT [] synonym: "regulation of interleukin-25 biosynthesis" EXACT [] synonym: "regulation of interleukin-25 formation" EXACT [] synonym: "regulation of interleukin-25 synthesis" EXACT [] is_a: GO:0032669 ! regulation of interleukin-25 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0045525 ! interleukin-25 biosynthetic process [Term] id: GO:0045530 name: regulation of interleukin-26 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] synonym: "regulation of IL-26 biosynthesis" EXACT [] synonym: "regulation of IL-26 biosynthetic process" EXACT [] synonym: "regulation of interleukin-26 anabolism" EXACT [] synonym: "regulation of interleukin-26 biosynthesis" EXACT [] synonym: "regulation of interleukin-26 formation" EXACT [] synonym: "regulation of interleukin-26 synthesis" EXACT [] is_a: GO:0032670 ! regulation of interleukin-26 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0045526 ! interleukin-26 biosynthetic process [Term] id: GO:0045531 name: regulation of interleukin-27 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] synonym: "regulation of IL-27 biosynthesis" EXACT [] synonym: "regulation of IL-27 biosynthetic process" EXACT [] synonym: "regulation of interleukin-27 anabolism" EXACT [] synonym: "regulation of interleukin-27 biosynthesis" EXACT [] synonym: "regulation of interleukin-27 formation" EXACT [] synonym: "regulation of interleukin-27 synthesis" EXACT [] is_a: GO:0032671 ! regulation of interleukin-27 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0045527 ! interleukin-27 biosynthetic process [Term] id: GO:0045532 name: negative regulation of interleukin-24 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] synonym: "down regulation of interleukin-24 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-24 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-24 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-24 biosynthetic process" NARROW [] synonym: "negative regulation of IL-24 biosynthesis" EXACT [] synonym: "negative regulation of IL-24 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-24 anabolism" EXACT [] synonym: "negative regulation of interleukin-24 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-24 formation" EXACT [] synonym: "negative regulation of interleukin-24 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process relationship: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process [Term] id: GO:0045533 name: negative regulation of interleukin-25 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] synonym: "down regulation of interleukin-25 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-25 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-25 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-25 biosynthetic process" NARROW [] synonym: "negative regulation of IL-25 biosynthesis" EXACT [] synonym: "negative regulation of IL-25 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-25 anabolism" EXACT [] synonym: "negative regulation of interleukin-25 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-25 formation" EXACT [] synonym: "negative regulation of interleukin-25 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process relationship: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process [Term] id: GO:0045534 name: negative regulation of interleukin-26 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] synonym: "down regulation of interleukin-26 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-26 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-26 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-26 biosynthetic process" NARROW [] synonym: "negative regulation of IL-26 biosynthesis" EXACT [] synonym: "negative regulation of IL-26 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-26 anabolism" EXACT [] synonym: "negative regulation of interleukin-26 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-26 formation" EXACT [] synonym: "negative regulation of interleukin-26 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process relationship: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process [Term] id: GO:0045535 name: negative regulation of interleukin-27 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] synonym: "down regulation of interleukin-27 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-27 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-27 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-27 biosynthetic process" NARROW [] synonym: "negative regulation of IL-27 biosynthesis" EXACT [] synonym: "negative regulation of IL-27 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-27 anabolism" EXACT [] synonym: "negative regulation of interleukin-27 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-27 formation" EXACT [] synonym: "negative regulation of interleukin-27 synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process relationship: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process [Term] id: GO:0045536 name: positive regulation of interleukin-24 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] synonym: "activation of interleukin-24 biosynthetic process" NARROW [] synonym: "positive regulation of IL-24 biosynthesis" EXACT [] synonym: "positive regulation of IL-24 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-24 anabolism" EXACT [] synonym: "positive regulation of interleukin-24 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-24 formation" EXACT [] synonym: "positive regulation of interleukin-24 synthesis" EXACT [] synonym: "stimulation of interleukin-24 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-24 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-24 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-24 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process relationship: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process [Term] id: GO:0045537 name: positive regulation of interleukin-25 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] synonym: "activation of interleukin-25 biosynthetic process" NARROW [] synonym: "positive regulation of IL-25 biosynthesis" EXACT [] synonym: "positive regulation of IL-25 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-25 anabolism" EXACT [] synonym: "positive regulation of interleukin-25 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-25 formation" EXACT [] synonym: "positive regulation of interleukin-25 synthesis" EXACT [] synonym: "stimulation of interleukin-25 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-25 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-25 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-25 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process relationship: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process [Term] id: GO:0045538 name: positive regulation of interleukin-26 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] synonym: "activation of interleukin-26 biosynthetic process" NARROW [] synonym: "positive regulation of IL-26 biosynthesis" EXACT [] synonym: "positive regulation of IL-26 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-26 anabolism" EXACT [] synonym: "positive regulation of interleukin-26 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-26 formation" EXACT [] synonym: "positive regulation of interleukin-26 synthesis" EXACT [] synonym: "stimulation of interleukin-26 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-26 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-26 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-26 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process relationship: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process [Term] id: GO:0045539 name: positive regulation of interleukin-27 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] synonym: "activation of interleukin-27 biosynthetic process" NARROW [] synonym: "positive regulation of IL-27 biosynthesis" EXACT [] synonym: "positive regulation of IL-27 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-27 anabolism" EXACT [] synonym: "positive regulation of interleukin-27 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-27 formation" EXACT [] synonym: "positive regulation of interleukin-27 synthesis" EXACT [] synonym: "stimulation of interleukin-27 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-27 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-27 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-27 biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process relationship: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process [Term] id: GO:0045540 name: regulation of cholesterol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] synonym: "regulation of cholesterol anabolism" EXACT [] synonym: "regulation of cholesterol biosynthesis" EXACT [] synonym: "regulation of cholesterol formation" EXACT [] synonym: "regulation of cholesterol synthesis" EXACT [] is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:0090181 ! regulation of cholesterol metabolic process relationship: regulates GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0045541 name: negative regulation of cholesterol biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] synonym: "down regulation of cholesterol biosynthetic process" EXACT [] synonym: "down-regulation of cholesterol biosynthetic process" EXACT [] synonym: "downregulation of cholesterol biosynthetic process" EXACT [] synonym: "inhibition of cholesterol biosynthetic process" NARROW [] synonym: "negative regulation of cholesterol anabolism" EXACT [] synonym: "negative regulation of cholesterol biosynthesis" EXACT [] synonym: "negative regulation of cholesterol formation" EXACT [] synonym: "negative regulation of cholesterol synthesis" EXACT [] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0045540 ! regulation of cholesterol biosynthetic process is_a: GO:0090206 ! negative regulation of cholesterol metabolic process relationship: negatively_regulates GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0045542 name: positive regulation of cholesterol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] synonym: "activation of cholesterol biosynthetic process" NARROW [] synonym: "positive regulation of cholesterol anabolism" EXACT [] synonym: "positive regulation of cholesterol biosynthesis" EXACT [] synonym: "positive regulation of cholesterol formation" EXACT [] synonym: "positive regulation of cholesterol synthesis" EXACT [] synonym: "stimulation of cholesterol biosynthetic process" NARROW [] synonym: "up regulation of cholesterol biosynthetic process" EXACT [] synonym: "up-regulation of cholesterol biosynthetic process" EXACT [] synonym: "upregulation of cholesterol biosynthetic process" EXACT [] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0045540 ! regulation of cholesterol biosynthetic process is_a: GO:0090205 ! positive regulation of cholesterol metabolic process relationship: positively_regulates GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0045543 name: gibberellin 2-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2." [EC:1.14.11.13, GOC:kad] synonym: "(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" NARROW [EC:1.14.11.13] synonym: "gibberellin 2-beta-hydroxylase activity" EXACT [EC:1.14.11.13] synonym: "gibberellin 2-oxidase activity" EXACT [] synonym: "gibberellin 2beta-dioxygenase activity" EXACT [EC:1.14.11.13] synonym: "gibberellin 2beta-hydroxylase activity" EXACT [EC:1.14.11.13] xref: EC:1.14.11.13 xref: MetaCyc:PWY-102 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0045544 name: gibberellin 20-oxidase activity namespace: molecular_function def: "Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones." [PMID:7604047] is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0045545 name: syndecan binding namespace: molecular_function def: "Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells." [GOC:go_curators, PMID:9355727] is_a: GO:0005515 ! protein binding [Term] id: GO:0045547 name: dehydrodolichyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [PMID:9858571] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0045548 name: phenylalanine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3." [EC:4.3.1.5] synonym: "L-phenylalanine ammonia-lyase (trans-cinnamate-forming)" EXACT [EC:4.3.1.5] synonym: "L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.5] synonym: "L-tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.5] synonym: "PAL" RELATED [EC:4.3.1.5] synonym: "phenylalanine ammonium-lyase activity" EXACT [EC:4.3.1.5] synonym: "phenylalanine deaminase activity" EXACT [EC:4.3.1.5] synonym: "tyrase activity" EXACT [EC:4.3.1.5] synonym: "tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.5] xref: EC:4.3.1.5 xref: MetaCyc:PHENYLALANINE-AMMONIA-LYASE-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0045549 name: 9-cis-epoxycarotenoid dioxygenase activity namespace: molecular_function def: "Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al." [EC:1.13.11.51] synonym: "9-cis-epoxycarotenoid 11,12-dioxygenase activity" EXACT [EC:1.13.11.51] synonym: "AtNCED3" RELATED [EC:1.13.11.51] synonym: "NCED" RELATED [EC:1.13.11.51] synonym: "neoxanthin cleavage enzyme" BROAD [] synonym: "nine-cis-epoxycarotenoid dioxygenase activity" EXACT [EC:1.13.11.51] synonym: "PvNCED1" RELATED [EC:1.13.11.51] synonym: "VP14" RELATED [EC:1.13.11.51] xref: EC:1.13.11.51 is_a: GO:0010436 ! carotenoid dioxygenase activity [Term] id: GO:0045550 name: geranylgeranyl reductase activity namespace: molecular_function def: "Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group." [PMID:9492312] subset: gosubset_prok is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0045551 name: cinnamyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+." [EC:1.1.1.195] synonym: "CAD activity" BROAD [EC:1.1.1.195] synonym: "cinnamyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.195] synonym: "cinnamyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.195] xref: EC:1.1.1.195 xref: MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0045552 name: dihydrokaempferol 4-reductase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219] subset: gosubset_prok synonym: "cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.219] synonym: "dihydroflavanol 4-reductase activity" EXACT [EC:1.1.1.219] synonym: "dihydroflavonol 4-reductase activity" EXACT [EC:1.1.1.219] synonym: "dihydromyricetin reductase activity" EXACT [EC:1.1.1.219] synonym: "dihydroquercetin reductase activity" EXACT [EC:1.1.1.219] synonym: "NADPH-dihydromyricetin reductase activity" EXACT [EC:1.1.1.219] xref: EC:1.1.1.219 xref: MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0045553 name: TRAIL biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor (TNF) family of cytokines which induces apoptosis in a wide variety of cells." [PMID:9311998] synonym: "TRAIL anabolism" EXACT [] synonym: "TRAIL biosynthesis" EXACT [] synonym: "TRAIL formation" EXACT [] synonym: "TRAIL synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032639 ! TRAIL production [Term] id: GO:0045554 name: regulation of TRAIL biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators] synonym: "regulation of TRAIL anabolism" EXACT [] synonym: "regulation of TRAIL biosynthesis" EXACT [] synonym: "regulation of TRAIL formation" EXACT [] synonym: "regulation of TRAIL synthesis" EXACT [] is_a: GO:0032679 ! regulation of TRAIL production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0045553 ! TRAIL biosynthetic process [Term] id: GO:0045555 name: negative regulation of TRAIL biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators] synonym: "down regulation of TRAIL biosynthetic process" EXACT [] synonym: "down-regulation of TRAIL biosynthetic process" EXACT [] synonym: "downregulation of TRAIL biosynthetic process" EXACT [] synonym: "inhibition of TRAIL biosynthetic process" NARROW [] synonym: "negative regulation of TRAIL anabolism" EXACT [] synonym: "negative regulation of TRAIL biosynthesis" EXACT [] synonym: "negative regulation of TRAIL formation" EXACT [] synonym: "negative regulation of TRAIL synthesis" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045554 ! regulation of TRAIL biosynthetic process relationship: negatively_regulates GO:0045553 ! TRAIL biosynthetic process [Term] id: GO:0045556 name: positive regulation of TRAIL biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators] synonym: "activation of TRAIL biosynthetic process" NARROW [] synonym: "positive regulation of TRAIL anabolism" EXACT [] synonym: "positive regulation of TRAIL biosynthesis" EXACT [] synonym: "positive regulation of TRAIL formation" EXACT [] synonym: "positive regulation of TRAIL synthesis" EXACT [] synonym: "stimulation of TRAIL biosynthetic process" NARROW [] synonym: "up regulation of TRAIL biosynthetic process" EXACT [] synonym: "up-regulation of TRAIL biosynthetic process" EXACT [] synonym: "upregulation of TRAIL biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045554 ! regulation of TRAIL biosynthetic process relationship: positively_regulates GO:0045553 ! TRAIL biosynthetic process [Term] id: GO:0045557 name: TRAIL receptor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] synonym: "TRAIL receptor anabolism" EXACT [] synonym: "TRAIL receptor biosynthesis" EXACT [] synonym: "TRAIL receptor formation" EXACT [] synonym: "TRAIL receptor synthesis" EXACT [] is_a: GO:0032800 ! receptor biosynthetic process [Term] id: GO:0045558 name: TRAIL receptor 1 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway." [GOC:go_curators, PMID:9311998] synonym: "TRAIL receptor 1 anabolism" EXACT [] synonym: "TRAIL receptor 1 biosynthesis" EXACT [] synonym: "TRAIL receptor 1 formation" EXACT [] synonym: "TRAIL receptor 1 synthesis" EXACT [] synonym: "tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PRO:000002108] is_a: GO:0045557 ! TRAIL receptor biosynthetic process [Term] id: GO:0045559 name: TRAIL receptor 2 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1." [GOC:go_curators, PMID:9311998] synonym: "TRAIL receptor 2 anabolism" EXACT [] synonym: "TRAIL receptor 2 biosynthesis" EXACT [] synonym: "TRAIL receptor 2 formation" EXACT [] synonym: "TRAIL receptor 2 synthesis" EXACT [] synonym: "tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PRO:000002109] is_a: GO:0045557 ! TRAIL receptor biosynthetic process [Term] id: GO:0045560 name: regulation of TRAIL receptor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] synonym: "regulation of TRAIL receptor anabolism" EXACT [] synonym: "regulation of TRAIL receptor biosynthesis" EXACT [] synonym: "regulation of TRAIL receptor formation" EXACT [] synonym: "regulation of TRAIL receptor synthesis" EXACT [] is_a: GO:0010869 ! regulation of receptor biosynthetic process relationship: regulates GO:0045557 ! TRAIL receptor biosynthetic process [Term] id: GO:0045561 name: regulation of TRAIL receptor 1 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] synonym: "regulation of TRAIL receptor 1 anabolism" EXACT [] synonym: "regulation of TRAIL receptor 1 biosynthesis" EXACT [] synonym: "regulation of TRAIL receptor 1 formation" EXACT [] synonym: "regulation of TRAIL receptor 1 synthesis" EXACT [] is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process relationship: regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process [Term] id: GO:0045562 name: regulation of TRAIL receptor 2 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] synonym: "regulation of TRAIL receptor 2 anabolism" EXACT [] synonym: "regulation of TRAIL receptor 2 biosynthesis" EXACT [] synonym: "regulation of TRAIL receptor 2 formation" EXACT [] synonym: "regulation of TRAIL receptor 2 synthesis" EXACT [] is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process relationship: regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process [Term] id: GO:0045563 name: negative regulation of TRAIL receptor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] synonym: "down regulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "down-regulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "downregulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "inhibition of TRAIL receptor biosynthetic process" NARROW [] synonym: "negative regulation of TRAIL receptor anabolism" EXACT [] synonym: "negative regulation of TRAIL receptor biosynthesis" EXACT [] synonym: "negative regulation of TRAIL receptor formation" EXACT [] synonym: "negative regulation of TRAIL receptor synthesis" EXACT [] is_a: GO:0010871 ! negative regulation of receptor biosynthetic process is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process relationship: negatively_regulates GO:0045557 ! TRAIL receptor biosynthetic process [Term] id: GO:0045564 name: positive regulation of TRAIL receptor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] synonym: "activation of TRAIL receptor biosynthetic process" NARROW [] synonym: "positive regulation of TRAIL receptor anabolism" EXACT [] synonym: "positive regulation of TRAIL receptor biosynthesis" EXACT [] synonym: "positive regulation of TRAIL receptor formation" EXACT [] synonym: "positive regulation of TRAIL receptor synthesis" EXACT [] synonym: "stimulation of TRAIL receptor biosynthetic process" NARROW [] synonym: "up regulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "up-regulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "upregulation of TRAIL receptor biosynthetic process" EXACT [] is_a: GO:0010870 ! positive regulation of receptor biosynthetic process is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process relationship: positively_regulates GO:0045557 ! TRAIL receptor biosynthetic process [Term] id: GO:0045565 name: negative regulation of TRAIL receptor 1 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] synonym: "down regulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "down-regulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "downregulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "inhibition of TRAIL receptor 1 biosynthetic process" NARROW [] synonym: "negative regulation of TRAIL receptor 1 anabolism" EXACT [] synonym: "negative regulation of TRAIL receptor 1 biosynthesis" EXACT [] synonym: "negative regulation of TRAIL receptor 1 formation" EXACT [] synonym: "negative regulation of TRAIL receptor 1 synthesis" EXACT [] is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process relationship: negatively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process [Term] id: GO:0045566 name: positive regulation of TRAIL receptor 1 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] synonym: "activation of TRAIL receptor 1 biosynthetic process" NARROW [] synonym: "positive regulation of TRAIL receptor 1 anabolism" EXACT [] synonym: "positive regulation of TRAIL receptor 1 biosynthesis" EXACT [] synonym: "positive regulation of TRAIL receptor 1 formation" EXACT [] synonym: "positive regulation of TRAIL receptor 1 synthesis" EXACT [] synonym: "stimulation of TRAIL receptor 1 biosynthetic process" NARROW [] synonym: "up regulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "up-regulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "upregulation of TRAIL receptor 1 biosynthetic process" EXACT [] is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process relationship: positively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process [Term] id: GO:0045567 name: negative regulation of TRAIL receptor 2 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] synonym: "down regulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "down-regulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "downregulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "inhibition of TRAIL receptor 2 biosynthetic process" NARROW [] synonym: "negative regulation of TRAIL receptor 2 anabolism" EXACT [] synonym: "negative regulation of TRAIL receptor 2 biosynthesis" EXACT [] synonym: "negative regulation of TRAIL receptor 2 formation" EXACT [] synonym: "negative regulation of TRAIL receptor 2 synthesis" EXACT [] is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process relationship: negatively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process [Term] id: GO:0045568 name: positive regulation of TRAIL receptor 2 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] synonym: "activation of TRAIL receptor 2 biosynthetic process" NARROW [] synonym: "positive regulation of TRAIL receptor 2 anabolism" EXACT [] synonym: "positive regulation of TRAIL receptor 2 biosynthesis" EXACT [] synonym: "positive regulation of TRAIL receptor 2 formation" EXACT [] synonym: "positive regulation of TRAIL receptor 2 synthesis" EXACT [] synonym: "stimulation of TRAIL receptor 2 biosynthetic process" NARROW [] synonym: "up regulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "up-regulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "upregulation of TRAIL receptor 2 biosynthetic process" EXACT [] is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process relationship: positively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process [Term] id: GO:0045569 name: TRAIL binding namespace: molecular_function def: "Interacting selectively and non-covalently with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:go_curators, PMID:9082980] synonym: "Apo-2L binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0045570 name: regulation of imaginal disc growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0007446 ! imaginal disc growth [Term] id: GO:0045571 name: negative regulation of imaginal disc growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] synonym: "down regulation of imaginal disc growth" EXACT [] synonym: "down-regulation of imaginal disc growth" EXACT [] synonym: "downregulation of imaginal disc growth" EXACT [] synonym: "inhibition of imaginal disc growth" NARROW [] is_a: GO:0045570 ! regulation of imaginal disc growth is_a: GO:0046621 ! negative regulation of organ growth is_a: GO:0048640 ! negative regulation of developmental growth relationship: negatively_regulates GO:0007446 ! imaginal disc growth [Term] id: GO:0045572 name: positive regulation of imaginal disc growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] synonym: "activation of imaginal disc growth" NARROW [] synonym: "stimulation of imaginal disc growth" NARROW [] synonym: "up regulation of imaginal disc growth" EXACT [] synonym: "up-regulation of imaginal disc growth" EXACT [] synonym: "upregulation of imaginal disc growth" EXACT [] is_a: GO:0045570 ! regulation of imaginal disc growth is_a: GO:0046622 ! positive regulation of organ growth is_a: GO:0048639 ! positive regulation of developmental growth relationship: positively_regulates GO:0007446 ! imaginal disc growth [Term] id: GO:0045574 name: sterigmatocystin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [CHEBI:18227, GOC:go_curators] subset: gosubset_prok synonym: "sterigmatocystin breakdown" EXACT [] synonym: "sterigmatocystin catabolism" EXACT [] synonym: "sterigmatocystin degradation" EXACT [] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0045460 ! sterigmatocystin metabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0045575 name: basophil activation namespace: biological_process def: "The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] xref: Wikipedia:Basophil_activation is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0045576 name: mast cell activation namespace: biological_process def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0045577 name: regulation of B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of B cell development" RELATED [GOC:add] synonym: "regulation of B lymphocyte differentiation" EXACT [] synonym: "regulation of B-cell differentiation" EXACT [] synonym: "regulation of B-lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0050864 ! regulation of B cell activation relationship: regulates GO:0030183 ! B cell differentiation [Term] id: GO:0045578 name: negative regulation of B cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of B cell differentiation" EXACT [] synonym: "down-regulation of B cell differentiation" EXACT [] synonym: "downregulation of B cell differentiation" EXACT [] synonym: "inhibition of B cell differentiation" NARROW [] synonym: "negative regulation of B cell development" RELATED [GOC:add] synonym: "negative regulation of B lymphocyte differentiation" EXACT [] synonym: "negative regulation of B-cell differentiation" EXACT [] synonym: "negative regulation of B-lymphocyte differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation is_a: GO:0050869 ! negative regulation of B cell activation relationship: negatively_regulates GO:0030183 ! B cell differentiation [Term] id: GO:0045579 name: positive regulation of B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of B cell differentiation" NARROW [] synonym: "positive regulation of B cell development" RELATED [GOC:add] synonym: "positive regulation of B lymphocyte differentiation" EXACT [] synonym: "positive regulation of B-cell differentiation" EXACT [] synonym: "positive regulation of B-lymphocyte differentiation" EXACT [] synonym: "stimulation of B cell differentiation" NARROW [] synonym: "up regulation of B cell differentiation" EXACT [] synonym: "up-regulation of B cell differentiation" EXACT [] synonym: "upregulation of B cell differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation is_a: GO:0050871 ! positive regulation of B cell activation relationship: positively_regulates GO:0030183 ! B cell differentiation [Term] id: GO:0045580 name: regulation of T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T cell development" RELATED [GOC:add] synonym: "regulation of T lymphocyte differentiation" EXACT [] synonym: "regulation of T-cell differentiation" EXACT [] synonym: "regulation of T-lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0050863 ! regulation of T cell activation relationship: regulates GO:0030217 ! T cell differentiation [Term] id: GO:0045581 name: negative regulation of T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T cell differentiation" EXACT [] synonym: "down-regulation of T cell differentiation" EXACT [] synonym: "downregulation of T cell differentiation" EXACT [] synonym: "inhibition of T cell differentiation" NARROW [] synonym: "negative regulation of T cell development" RELATED [GOC:add] synonym: "negative regulation of T lymphocyte differentiation" EXACT [] synonym: "negative regulation of T-cell differentiation" EXACT [] synonym: "negative regulation of T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation is_a: GO:0050868 ! negative regulation of T cell activation relationship: negatively_regulates GO:0030217 ! T cell differentiation [Term] id: GO:0045582 name: positive regulation of T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T cell differentiation" NARROW [] synonym: "positive regulation of T cell development" RELATED [GOC:add] synonym: "positive regulation of T lymphocyte differentiation" EXACT [] synonym: "positive regulation of T-cell differentiation" EXACT [] synonym: "positive regulation of T-lymphocyte differentiation" EXACT [] synonym: "stimulation of T cell differentiation" NARROW [] synonym: "up regulation of T cell differentiation" EXACT [] synonym: "up-regulation of T cell differentiation" EXACT [] synonym: "upregulation of T cell differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation is_a: GO:0050870 ! positive regulation of T cell activation relationship: positively_regulates GO:0030217 ! T cell differentiation [Term] id: GO:0045583 name: regulation of cytotoxic T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of cytotoxic T cell development" RELATED [GOC:add] synonym: "regulation of cytotoxic T lymphocyte differentiation" EXACT [] synonym: "regulation of cytotoxic T-cell differentiation" EXACT [] synonym: "regulation of cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation relationship: regulates GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0045584 name: negative regulation of cytotoxic T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of cytotoxic T cell differentiation" EXACT [] synonym: "down-regulation of cytotoxic T cell differentiation" EXACT [] synonym: "downregulation of cytotoxic T cell differentiation" EXACT [] synonym: "inhibition of cytotoxic T cell differentiation" NARROW [] synonym: "negative regulation of cytotoxic T cell development" RELATED [GOC:add] synonym: "negative regulation of cytotoxic T lymphocyte differentiation" EXACT [] synonym: "negative regulation of cytotoxic T-cell differentiation" EXACT [] synonym: "negative regulation of cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation relationship: negatively_regulates GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0045585 name: positive regulation of cytotoxic T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of cytotoxic T cell differentiation" NARROW [] synonym: "positive regulation of cytotoxic T cell development" RELATED [GOC:add] synonym: "positive regulation of cytotoxic T lymphocyte differentiation" EXACT [] synonym: "positive regulation of cytotoxic T-cell differentiation" EXACT [] synonym: "positive regulation of cytotoxic T-lymphocyte differentiation" EXACT [] synonym: "stimulation of cytotoxic T cell differentiation" NARROW [] synonym: "up regulation of cytotoxic T cell differentiation" EXACT [] synonym: "up-regulation of cytotoxic T cell differentiation" EXACT [] synonym: "upregulation of cytotoxic T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation relationship: positively_regulates GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0045586 name: regulation of gamma-delta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of gamma-delta T cell development" RELATED [GOC:add] synonym: "regulation of gamma-delta T lymphocyte differentiation" EXACT [] synonym: "regulation of gamma-delta T-cell differentiation" EXACT [] synonym: "regulation of gamma-delta T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0046643 ! regulation of gamma-delta T cell activation relationship: regulates GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0045587 name: negative regulation of gamma-delta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of gamma-delta T cell differentiation" EXACT [] synonym: "down-regulation of gamma-delta T cell differentiation" EXACT [] synonym: "downregulation of gamma-delta T cell differentiation" EXACT [] synonym: "inhibition of gamma-delta T cell differentiation" NARROW [] synonym: "negative regulation of gamma-delta T cell development" RELATED [GOC:add] synonym: "negative regulation of gamma-delta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of gamma-delta T-cell differentiation" EXACT [] synonym: "negative regulation of gamma-delta T-lymphocyte differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation relationship: negatively_regulates GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0045588 name: positive regulation of gamma-delta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of gamma-delta T cell differentiation" NARROW [] synonym: "positive regulation of gamma-delta T cell development" RELATED [GOC:add] synonym: "positive regulation of gamma-delta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of gamma-delta T-cell differentiation" EXACT [] synonym: "positive regulation of gamma-delta T-lymphocyte differentiation" EXACT [] synonym: "stimulation of gamma-delta T cell differentiation" NARROW [] synonym: "up regulation of gamma-delta T cell differentiation" EXACT [] synonym: "up-regulation of gamma-delta T cell differentiation" EXACT [] synonym: "upregulation of gamma-delta T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation relationship: positively_regulates GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0045589 name: regulation of regulatory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of regulatory T cell development" RELATED [GOC:add] synonym: "regulation of regulatory T lymphocyte differentiation" EXACT [] synonym: "regulation of regulatory T-cell differentiation" EXACT [] synonym: "regulation of regulatory T-lymphocyte differentiation" EXACT [] synonym: "regulation of suppressor T cell differentiation" EXACT [] synonym: "regulation of suppressor T lymphocyte differentiation" EXACT [] synonym: "regulation of suppressor T-cell differentiation" EXACT [] synonym: "regulation of suppressor T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation relationship: regulates GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0045590 name: negative regulation of regulatory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of regulatory T cell differentiation" EXACT [] synonym: "down-regulation of regulatory T cell differentiation" EXACT [] synonym: "downregulation of regulatory T cell differentiation" EXACT [] synonym: "inhibition of regulatory T cell differentiation" NARROW [] synonym: "negative regulation of regulatory T cell development" RELATED [GOC:add] synonym: "negative regulation of regulatory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of regulatory T-cell differentiation" EXACT [] synonym: "negative regulation of regulatory T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of suppressor T cell differentiation" EXACT [] synonym: "negative regulation of suppressor T-cell differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation relationship: negatively_regulates GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0045591 name: positive regulation of regulatory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149 "Fundamental Immunology"] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of regulatory T cell differentiation" NARROW [] synonym: "positive regulation of regulatory T cell development" RELATED [GOC:add] synonym: "positive regulation of regulatory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of regulatory T-cell differentiation" EXACT [] synonym: "positive regulation of regulatory T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of suppressor T cell differentiation" EXACT [] synonym: "positive regulation of suppressor T-cell differentiation" EXACT [] synonym: "stimulation of regulatory T cell differentiation" NARROW [] synonym: "up regulation of regulatory T cell differentiation" EXACT [] synonym: "up-regulation of regulatory T cell differentiation" EXACT [] synonym: "upregulation of regulatory T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation relationship: positively_regulates GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0045592 name: regulation of cumulus cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] synonym: "regulation of ovarian cumulus cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000387 ! regulation of antral ovarian follicle growth relationship: regulates GO:0001549 ! cumulus cell differentiation [Term] id: GO:0045593 name: negative regulation of cumulus cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] synonym: "down regulation of cumulus cell differentiation" EXACT [] synonym: "down-regulation of cumulus cell differentiation" EXACT [] synonym: "downregulation of cumulus cell differentiation" EXACT [] synonym: "inhibition of cumulus cell differentiation" NARROW [] synonym: "negative regulation of ovarian cumulus cell differentiation" EXACT [] is_a: GO:0045592 ! regulation of cumulus cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0001549 ! cumulus cell differentiation [Term] id: GO:0045594 name: positive regulation of cumulus cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] synonym: "activation of cumulus cell differentiation" NARROW [] synonym: "positive regulation of ovarian cumulus cell differentiation" EXACT [] synonym: "stimulation of cumulus cell differentiation" NARROW [] synonym: "up regulation of cumulus cell differentiation" EXACT [] synonym: "up-regulation of cumulus cell differentiation" EXACT [] synonym: "upregulation of cumulus cell differentiation" EXACT [] is_a: GO:0045592 ! regulation of cumulus cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0001549 ! cumulus cell differentiation [Term] id: GO:0045595 name: regulation of cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0030154 ! cell differentiation [Term] id: GO:0045596 name: negative regulation of cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of cell differentiation" EXACT [] synonym: "down-regulation of cell differentiation" EXACT [] synonym: "downregulation of cell differentiation" EXACT [] synonym: "inhibition of cell differentiation" NARROW [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0030154 ! cell differentiation [Term] id: GO:0045597 name: positive regulation of cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] subset: gosubset_prok synonym: "activation of cell differentiation" NARROW [] synonym: "stimulation of cell differentiation" NARROW [] synonym: "up regulation of cell differentiation" EXACT [] synonym: "up-regulation of cell differentiation" EXACT [] synonym: "upregulation of cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0030154 ! cell differentiation [Term] id: GO:0045598 name: regulation of fat cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "regulation of adipocyte cell differentiation" EXACT [] synonym: "regulation of adipocyte differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0045444 ! fat cell differentiation [Term] id: GO:0045599 name: negative regulation of fat cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "down regulation of fat cell differentiation" EXACT [] synonym: "down-regulation of fat cell differentiation" EXACT [] synonym: "downregulation of fat cell differentiation" EXACT [] synonym: "inhibition of fat cell differentiation" NARROW [] synonym: "negative regulation of adipocyte cell differentiation" EXACT [] synonym: "negative regulation of adipocyte differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation relationship: negatively_regulates GO:0045444 ! fat cell differentiation [Term] id: GO:0045600 name: positive regulation of fat cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "activation of fat cell differentiation" NARROW [] synonym: "positive regulation of adipocyte cell differentiation" EXACT [] synonym: "positive regulation of adipocyte differentiation" EXACT [] synonym: "stimulation of fat cell differentiation" NARROW [] synonym: "up regulation of fat cell differentiation" EXACT [] synonym: "up-regulation of fat cell differentiation" EXACT [] synonym: "upregulation of fat cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation relationship: positively_regulates GO:0045444 ! fat cell differentiation [Term] id: GO:0045601 name: regulation of endothelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] is_a: GO:0030856 ! regulation of epithelial cell differentiation relationship: regulates GO:0045446 ! endothelial cell differentiation [Term] id: GO:0045602 name: negative regulation of endothelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "down regulation of endothelial cell differentiation" EXACT [] synonym: "down-regulation of endothelial cell differentiation" EXACT [] synonym: "downregulation of endothelial cell differentiation" EXACT [] synonym: "inhibition of endothelial cell differentiation" NARROW [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation relationship: negatively_regulates GO:0045446 ! endothelial cell differentiation [Term] id: GO:0045603 name: positive regulation of endothelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "activation of endothelial cell differentiation" NARROW [] synonym: "stimulation of endothelial cell differentiation" NARROW [] synonym: "up regulation of endothelial cell differentiation" EXACT [] synonym: "up-regulation of endothelial cell differentiation" EXACT [] synonym: "upregulation of endothelial cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation relationship: positively_regulates GO:0045446 ! endothelial cell differentiation [Term] id: GO:0045604 name: regulation of epidermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0045682 ! regulation of epidermis development relationship: regulates GO:0009913 ! epidermal cell differentiation [Term] id: GO:0045605 name: negative regulation of epidermal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "down regulation of epidermal cell differentiation" EXACT [] synonym: "down-regulation of epidermal cell differentiation" EXACT [] synonym: "downregulation of epidermal cell differentiation" EXACT [] synonym: "inhibition of epidermal cell differentiation" NARROW [] synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045683 ! negative regulation of epidermis development relationship: negatively_regulates GO:0009913 ! epidermal cell differentiation [Term] id: GO:0045606 name: positive regulation of epidermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "activation of epidermal cell differentiation" NARROW [] synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermal cell differentiation" NARROW [] synonym: "up regulation of epidermal cell differentiation" EXACT [] synonym: "up-regulation of epidermal cell differentiation" EXACT [] synonym: "upregulation of epidermal cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045684 ! positive regulation of epidermis development relationship: positively_regulates GO:0009913 ! epidermal cell differentiation [Term] id: GO:0045607 name: regulation of auditory receptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] synonym: "regulation of auditory hair cell differentiation" EXACT [] is_a: GO:0045631 ! regulation of mechanoreceptor differentiation relationship: regulates GO:0042491 ! auditory receptor cell differentiation [Term] id: GO:0045608 name: negative regulation of auditory receptor cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] synonym: "down regulation of auditory receptor cell differentiation" EXACT [] synonym: "down-regulation of auditory receptor cell differentiation" EXACT [] synonym: "downregulation of auditory receptor cell differentiation" EXACT [] synonym: "inhibition of auditory receptor cell differentiation" NARROW [] synonym: "negative regulation of auditory hair cell differentiation" EXACT [] is_a: GO:0045607 ! regulation of auditory receptor cell differentiation is_a: GO:0045632 ! negative regulation of mechanoreceptor differentiation relationship: negatively_regulates GO:0042491 ! auditory receptor cell differentiation [Term] id: GO:0045609 name: positive regulation of auditory receptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] synonym: "activation of auditory receptor cell differentiation" NARROW [] synonym: "positive regulation of auditory hair cell differentiation" EXACT [] synonym: "stimulation of auditory receptor cell differentiation" NARROW [] synonym: "up regulation of auditory receptor cell differentiation" EXACT [] synonym: "up-regulation of auditory receptor cell differentiation" EXACT [] synonym: "upregulation of auditory receptor cell differentiation" EXACT [] is_a: GO:0045607 ! regulation of auditory receptor cell differentiation is_a: GO:0045633 ! positive regulation of mechanoreceptor differentiation relationship: positively_regulates GO:0042491 ! auditory receptor cell differentiation [Term] id: GO:0045610 name: regulation of hemocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] synonym: "regulation of arthropod blood cell differentiation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0042386 ! hemocyte differentiation [Term] id: GO:0045611 name: negative regulation of hemocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] synonym: "down regulation of hemocyte differentiation" EXACT [] synonym: "down-regulation of hemocyte differentiation" EXACT [] synonym: "downregulation of hemocyte differentiation" EXACT [] synonym: "inhibition of hemocyte differentiation" NARROW [] synonym: "negative regulation of arthropod blood cell differentiation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045610 ! regulation of hemocyte differentiation relationship: negatively_regulates GO:0042386 ! hemocyte differentiation [Term] id: GO:0045612 name: positive regulation of hemocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] synonym: "activation of hemocyte differentiation" NARROW [] synonym: "positive regulation of arthropod blood cell differentiation" EXACT [] synonym: "stimulation of hemocyte differentiation" NARROW [] synonym: "up regulation of hemocyte differentiation" EXACT [] synonym: "up-regulation of hemocyte differentiation" EXACT [] synonym: "upregulation of hemocyte differentiation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045610 ! regulation of hemocyte differentiation relationship: positively_regulates GO:0042386 ! hemocyte differentiation [Term] id: GO:0045613 name: regulation of plasmatocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] is_a: GO:0045610 ! regulation of hemocyte differentiation relationship: regulates GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0045614 name: negative regulation of plasmatocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] synonym: "down regulation of plasmatocyte differentiation" EXACT [] synonym: "down-regulation of plasmatocyte differentiation" EXACT [] synonym: "downregulation of plasmatocyte differentiation" EXACT [] synonym: "inhibition of plasmatocyte differentiation" NARROW [] is_a: GO:0045611 ! negative regulation of hemocyte differentiation is_a: GO:0045613 ! regulation of plasmatocyte differentiation relationship: negatively_regulates GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0045615 name: positive regulation of plasmatocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] synonym: "activation of plasmatocyte differentiation" NARROW [] synonym: "stimulation of plasmatocyte differentiation" NARROW [] synonym: "up regulation of plasmatocyte differentiation" EXACT [] synonym: "up-regulation of plasmatocyte differentiation" EXACT [] synonym: "upregulation of plasmatocyte differentiation" EXACT [] is_a: GO:0045612 ! positive regulation of hemocyte differentiation is_a: GO:0045613 ! regulation of plasmatocyte differentiation relationship: positively_regulates GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0045616 name: regulation of keratinocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation relationship: regulates GO:0030216 ! keratinocyte differentiation [Term] id: GO:0045617 name: negative regulation of keratinocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] synonym: "down regulation of keratinocyte differentiation" EXACT [] synonym: "down-regulation of keratinocyte differentiation" EXACT [] synonym: "downregulation of keratinocyte differentiation" EXACT [] synonym: "inhibition of keratinocyte differentiation" NARROW [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045605 ! negative regulation of epidermal cell differentiation is_a: GO:0045616 ! regulation of keratinocyte differentiation relationship: negatively_regulates GO:0030216 ! keratinocyte differentiation [Term] id: GO:0045618 name: positive regulation of keratinocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] synonym: "activation of keratinocyte differentiation" NARROW [] synonym: "stimulation of keratinocyte differentiation" NARROW [] synonym: "up regulation of keratinocyte differentiation" EXACT [] synonym: "up-regulation of keratinocyte differentiation" EXACT [] synonym: "upregulation of keratinocyte differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045606 ! positive regulation of epidermal cell differentiation is_a: GO:0045616 ! regulation of keratinocyte differentiation relationship: positively_regulates GO:0030216 ! keratinocyte differentiation [Term] id: GO:0045619 name: regulation of lymphocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of lymphocyte development" RELATED [GOC:add] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0051249 ! regulation of lymphocyte activation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0030098 ! lymphocyte differentiation [Term] id: GO:0045620 name: negative regulation of lymphocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of lymphocyte differentiation" EXACT [] synonym: "down-regulation of lymphocyte differentiation" EXACT [] synonym: "downregulation of lymphocyte differentiation" EXACT [] synonym: "inhibition of lymphocyte differentiation" NARROW [] synonym: "negative regulation of lymphocyte development" RELATED [GOC:add] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051250 ! negative regulation of lymphocyte activation relationship: negatively_regulates GO:0030098 ! lymphocyte differentiation [Term] id: GO:0045621 name: positive regulation of lymphocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of lymphocyte differentiation" NARROW [] synonym: "positive regulation of lymphocyte development" RELATED [GOC:add] synonym: "stimulation of lymphocyte differentiation" NARROW [] synonym: "up regulation of lymphocyte differentiation" EXACT [] synonym: "up-regulation of lymphocyte differentiation" EXACT [] synonym: "upregulation of lymphocyte differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051251 ! positive regulation of lymphocyte activation relationship: positively_regulates GO:0030098 ! lymphocyte differentiation [Term] id: GO:0045622 name: regulation of T-helper cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T-helper cell development" RELATED [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0042093 ! T-helper cell differentiation [Term] id: GO:0045623 name: negative regulation of T-helper cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T-helper cell differentiation" EXACT [] synonym: "down-regulation of T-helper cell differentiation" EXACT [] synonym: "downregulation of T-helper cell differentiation" EXACT [] synonym: "inhibition of T-helper cell differentiation" NARROW [] synonym: "negative regulation of T-helper cell development" RELATED [GOC:add] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045622 ! regulation of T-helper cell differentiation relationship: negatively_regulates GO:0042093 ! T-helper cell differentiation [Term] id: GO:0045624 name: positive regulation of T-helper cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T-helper cell differentiation" NARROW [] synonym: "positive regulation of T-helper cell development" RELATED [GOC:add] synonym: "stimulation of T-helper cell differentiation" NARROW [] synonym: "up regulation of T-helper cell differentiation" EXACT [] synonym: "up-regulation of T-helper cell differentiation" EXACT [] synonym: "upregulation of T-helper cell differentiation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045622 ! regulation of T-helper cell differentiation relationship: positively_regulates GO:0042093 ! T-helper cell differentiation [Term] id: GO:0045625 name: regulation of T-helper 1 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T-helper 1 cell development" RELATED [GOC:add] is_a: GO:0002825 ! regulation of T-helper 1 type immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation relationship: regulates GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0045626 name: negative regulation of T-helper 1 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T-helper 1 cell differentiation" EXACT [] synonym: "down-regulation of T-helper 1 cell differentiation" EXACT [] synonym: "downregulation of T-helper 1 cell differentiation" EXACT [] synonym: "inhibition of T-helper 1 cell differentiation" NARROW [] synonym: "negative regulation of T-helper 1 cell development" RELATED [GOC:add] is_a: GO:0045623 ! negative regulation of T-helper cell differentiation is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation relationship: negatively_regulates GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0045627 name: positive regulation of T-helper 1 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T-helper 1 cell differentiation" NARROW [] synonym: "positive regulation of T-helper 1 cell development" RELATED [GOC:add] synonym: "stimulation of T-helper 1 cell differentiation" NARROW [] synonym: "up regulation of T-helper 1 cell differentiation" EXACT [] synonym: "up-regulation of T-helper 1 cell differentiation" EXACT [] synonym: "upregulation of T-helper 1 cell differentiation" EXACT [] is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation relationship: positively_regulates GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0045628 name: regulation of T-helper 2 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T-helper 2 cell development" RELATED [GOC:add] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation relationship: regulates GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0045629 name: negative regulation of T-helper 2 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T-helper 2 cell differentiation" EXACT [] synonym: "down-regulation of T-helper 2 cell differentiation" EXACT [] synonym: "downregulation of T-helper 2 cell differentiation" EXACT [] synonym: "inhibition of T-helper 2 cell differentiation" NARROW [] synonym: "negative regulation of T-helper 2 cell development" RELATED [GOC:add] is_a: GO:0045623 ! negative regulation of T-helper cell differentiation is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation relationship: negatively_regulates GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0045630 name: positive regulation of T-helper 2 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T-helper 2 cell differentiation" NARROW [] synonym: "positive regulation of T-helper 2 cell development" RELATED [GOC:add] synonym: "stimulation of T-helper 2 cell differentiation" NARROW [] synonym: "up regulation of T-helper 2 cell differentiation" EXACT [] synonym: "up-regulation of T-helper 2 cell differentiation" EXACT [] synonym: "upregulation of T-helper 2 cell differentiation" EXACT [] is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation relationship: positively_regulates GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0045631 name: regulation of mechanoreceptor differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] is_a: GO:0045664 ! regulation of neuron differentiation relationship: regulates GO:0042490 ! mechanoreceptor differentiation [Term] id: GO:0045632 name: negative regulation of mechanoreceptor differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] synonym: "down regulation of mechanoreceptor differentiation" EXACT [] synonym: "down-regulation of mechanoreceptor differentiation" EXACT [] synonym: "downregulation of mechanoreceptor differentiation" EXACT [] synonym: "inhibition of mechanoreceptor differentiation" NARROW [] is_a: GO:0045631 ! regulation of mechanoreceptor differentiation is_a: GO:0045665 ! negative regulation of neuron differentiation relationship: negatively_regulates GO:0042490 ! mechanoreceptor differentiation [Term] id: GO:0045633 name: positive regulation of mechanoreceptor differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] synonym: "activation of mechanoreceptor differentiation" NARROW [] synonym: "stimulation of mechanoreceptor differentiation" NARROW [] synonym: "up regulation of mechanoreceptor differentiation" EXACT [] synonym: "up-regulation of mechanoreceptor differentiation" EXACT [] synonym: "upregulation of mechanoreceptor differentiation" EXACT [] is_a: GO:0045631 ! regulation of mechanoreceptor differentiation is_a: GO:0045666 ! positive regulation of neuron differentiation relationship: positively_regulates GO:0042490 ! mechanoreceptor differentiation [Term] id: GO:0045634 name: regulation of melanocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] synonym: "regulation of melanophore differentiation" EXACT [] is_a: GO:0050932 ! regulation of pigment cell differentiation relationship: regulates GO:0030318 ! melanocyte differentiation [Term] id: GO:0045635 name: negative regulation of melanocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] synonym: "down regulation of melanocyte differentiation" EXACT [] synonym: "down-regulation of melanocyte differentiation" EXACT [] synonym: "downregulation of melanocyte differentiation" EXACT [] synonym: "inhibition of melanocyte differentiation" NARROW [] synonym: "negative regulation of melanophore differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation relationship: negatively_regulates GO:0030318 ! melanocyte differentiation [Term] id: GO:0045636 name: positive regulation of melanocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] synonym: "activation of melanocyte differentiation" NARROW [] synonym: "positive regulation of melanophore differentiation" EXACT [] synonym: "stimulation of melanocyte differentiation" NARROW [] synonym: "up regulation of melanocyte differentiation" EXACT [] synonym: "up-regulation of melanocyte differentiation" EXACT [] synonym: "upregulation of melanocyte differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation relationship: positively_regulates GO:0030318 ! melanocyte differentiation [Term] id: GO:0045637 name: regulation of myeloid cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0030099 ! myeloid cell differentiation [Term] id: GO:0045638 name: negative regulation of myeloid cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "down regulation of myeloid cell differentiation" EXACT [] synonym: "down-regulation of myeloid cell differentiation" EXACT [] synonym: "downregulation of myeloid cell differentiation" EXACT [] synonym: "inhibition of myeloid cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation relationship: negatively_regulates GO:0030099 ! myeloid cell differentiation [Term] id: GO:0045639 name: positive regulation of myeloid cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "activation of myeloid cell differentiation" NARROW [] synonym: "stimulation of myeloid cell differentiation" NARROW [] synonym: "up regulation of myeloid cell differentiation" EXACT [] synonym: "up-regulation of myeloid cell differentiation" EXACT [] synonym: "upregulation of myeloid cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation relationship: positively_regulates GO:0030099 ! myeloid cell differentiation [Term] id: GO:0045640 name: regulation of basophil differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basophil differentiation." [GOC:go_curators] is_a: GO:0030852 ! regulation of granulocyte differentiation relationship: regulates GO:0030221 ! basophil differentiation [Term] id: GO:0045641 name: negative regulation of basophil differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation." [GOC:go_curators] synonym: "down regulation of basophil differentiation" EXACT [] synonym: "down-regulation of basophil differentiation" EXACT [] synonym: "downregulation of basophil differentiation" EXACT [] synonym: "inhibition of basophil differentiation" NARROW [] is_a: GO:0030853 ! negative regulation of granulocyte differentiation is_a: GO:0045640 ! regulation of basophil differentiation relationship: negatively_regulates GO:0030221 ! basophil differentiation [Term] id: GO:0045642 name: positive regulation of basophil differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of basophil differentiation." [GOC:go_curators] synonym: "activation of basophil differentiation" NARROW [] synonym: "stimulation of basophil differentiation" NARROW [] synonym: "up regulation of basophil differentiation" EXACT [] synonym: "up-regulation of basophil differentiation" EXACT [] synonym: "upregulation of basophil differentiation" EXACT [] is_a: GO:0030854 ! positive regulation of granulocyte differentiation is_a: GO:0045640 ! regulation of basophil differentiation relationship: positively_regulates GO:0030221 ! basophil differentiation [Term] id: GO:0045643 name: regulation of eosinophil differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] is_a: GO:0030852 ! regulation of granulocyte differentiation relationship: regulates GO:0030222 ! eosinophil differentiation [Term] id: GO:0045644 name: negative regulation of eosinophil differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] synonym: "down regulation of eosinophil differentiation" EXACT [] synonym: "down-regulation of eosinophil differentiation" EXACT [] synonym: "downregulation of eosinophil differentiation" EXACT [] synonym: "inhibition of eosinophil differentiation" NARROW [] is_a: GO:0030853 ! negative regulation of granulocyte differentiation is_a: GO:0045643 ! regulation of eosinophil differentiation relationship: negatively_regulates GO:0030222 ! eosinophil differentiation [Term] id: GO:0045645 name: positive regulation of eosinophil differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] synonym: "activation of eosinophil differentiation" NARROW [] synonym: "stimulation of eosinophil differentiation" NARROW [] synonym: "up regulation of eosinophil differentiation" EXACT [] synonym: "up-regulation of eosinophil differentiation" EXACT [] synonym: "upregulation of eosinophil differentiation" EXACT [] is_a: GO:0030854 ! positive regulation of granulocyte differentiation is_a: GO:0045643 ! regulation of eosinophil differentiation relationship: positively_regulates GO:0030222 ! eosinophil differentiation [Term] id: GO:0045646 name: regulation of erythrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "regulation of RBC differentiation" EXACT [CL:0000232] synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0045637 ! regulation of myeloid cell differentiation relationship: regulates GO:0030218 ! erythrocyte differentiation [Term] id: GO:0045647 name: negative regulation of erythrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "down regulation of erythrocyte differentiation" EXACT [] synonym: "down-regulation of erythrocyte differentiation" EXACT [] synonym: "downregulation of erythrocyte differentiation" EXACT [] synonym: "inhibition of erythrocyte differentiation" NARROW [] synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232] synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation relationship: negatively_regulates GO:0030218 ! erythrocyte differentiation [Term] id: GO:0045648 name: positive regulation of erythrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "activation of erythrocyte differentiation" NARROW [] synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232] synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232] synonym: "stimulation of erythrocyte differentiation" NARROW [] synonym: "up regulation of erythrocyte differentiation" EXACT [] synonym: "up-regulation of erythrocyte differentiation" EXACT [] synonym: "upregulation of erythrocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation relationship: positively_regulates GO:0030218 ! erythrocyte differentiation [Term] id: GO:0045649 name: regulation of macrophage differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation relationship: regulates GO:0030225 ! macrophage differentiation [Term] id: GO:0045650 name: negative regulation of macrophage differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] synonym: "down regulation of macrophage differentiation" EXACT [] synonym: "down-regulation of macrophage differentiation" EXACT [] synonym: "downregulation of macrophage differentiation" EXACT [] synonym: "inhibition of macrophage differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045649 ! regulation of macrophage differentiation relationship: negatively_regulates GO:0030225 ! macrophage differentiation [Term] id: GO:0045651 name: positive regulation of macrophage differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] synonym: "activation of macrophage differentiation" NARROW [] synonym: "stimulation of macrophage differentiation" NARROW [] synonym: "up regulation of macrophage differentiation" EXACT [] synonym: "up-regulation of macrophage differentiation" EXACT [] synonym: "upregulation of macrophage differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045649 ! regulation of macrophage differentiation relationship: positively_regulates GO:0030225 ! macrophage differentiation [Term] id: GO:0045652 name: regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] is_a: GO:0045637 ! regulation of myeloid cell differentiation relationship: regulates GO:0030219 ! megakaryocyte differentiation [Term] id: GO:0045653 name: negative regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "down regulation of megakaryocyte differentiation" EXACT [] synonym: "down-regulation of megakaryocyte differentiation" EXACT [] synonym: "downregulation of megakaryocyte differentiation" EXACT [] synonym: "inhibition of megakaryocyte differentiation" NARROW [] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation relationship: negatively_regulates GO:0030219 ! megakaryocyte differentiation [Term] id: GO:0045654 name: positive regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "activation of megakaryocyte differentiation" NARROW [] synonym: "stimulation of megakaryocyte differentiation" NARROW [] synonym: "up regulation of megakaryocyte differentiation" EXACT [] synonym: "up-regulation of megakaryocyte differentiation" EXACT [] synonym: "upregulation of megakaryocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation relationship: positively_regulates GO:0030219 ! megakaryocyte differentiation [Term] id: GO:0045655 name: regulation of monocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation relationship: regulates GO:0030224 ! monocyte differentiation [Term] id: GO:0045656 name: negative regulation of monocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] synonym: "down regulation of monocyte differentiation" EXACT [] synonym: "down-regulation of monocyte differentiation" EXACT [] synonym: "downregulation of monocyte differentiation" EXACT [] synonym: "inhibition of monocyte differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045655 ! regulation of monocyte differentiation relationship: negatively_regulates GO:0030224 ! monocyte differentiation [Term] id: GO:0045657 name: positive regulation of monocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] synonym: "activation of monocyte differentiation" NARROW [] synonym: "stimulation of monocyte differentiation" NARROW [] synonym: "up regulation of monocyte differentiation" EXACT [] synonym: "up-regulation of monocyte differentiation" EXACT [] synonym: "upregulation of monocyte differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045655 ! regulation of monocyte differentiation relationship: positively_regulates GO:0030224 ! monocyte differentiation [Term] id: GO:0045658 name: regulation of neutrophil differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] is_a: GO:0030852 ! regulation of granulocyte differentiation relationship: regulates GO:0030223 ! neutrophil differentiation [Term] id: GO:0045659 name: negative regulation of neutrophil differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] synonym: "down regulation of neutrophil differentiation" EXACT [] synonym: "down-regulation of neutrophil differentiation" EXACT [] synonym: "downregulation of neutrophil differentiation" EXACT [] synonym: "inhibition of neutrophil differentiation" NARROW [] is_a: GO:0030853 ! negative regulation of granulocyte differentiation is_a: GO:0045658 ! regulation of neutrophil differentiation relationship: negatively_regulates GO:0030223 ! neutrophil differentiation [Term] id: GO:0045660 name: positive regulation of neutrophil differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] synonym: "activation of neutrophil differentiation" NARROW [] synonym: "stimulation of neutrophil differentiation" NARROW [] synonym: "up regulation of neutrophil differentiation" EXACT [] synonym: "up-regulation of neutrophil differentiation" EXACT [] synonym: "upregulation of neutrophil differentiation" EXACT [] is_a: GO:0030854 ! positive regulation of granulocyte differentiation is_a: GO:0045658 ! regulation of neutrophil differentiation relationship: positively_regulates GO:0030223 ! neutrophil differentiation [Term] id: GO:0045661 name: regulation of myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] is_a: GO:0048742 ! regulation of skeletal muscle fiber development relationship: regulates GO:0045445 ! myoblast differentiation [Term] id: GO:0045662 name: negative regulation of myoblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "down regulation of myoblast differentiation" EXACT [] synonym: "down-regulation of myoblast differentiation" EXACT [] synonym: "downregulation of myoblast differentiation" EXACT [] synonym: "inhibition of myoblast differentiation" NARROW [] is_a: GO:0045661 ! regulation of myoblast differentiation is_a: GO:0051148 ! negative regulation of muscle cell differentiation relationship: negatively_regulates GO:0045445 ! myoblast differentiation [Term] id: GO:0045663 name: positive regulation of myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "activation of myoblast differentiation" NARROW [] synonym: "stimulation of myoblast differentiation" NARROW [] synonym: "up regulation of myoblast differentiation" EXACT [] synonym: "up-regulation of myoblast differentiation" EXACT [] synonym: "upregulation of myoblast differentiation" EXACT [] is_a: GO:0045661 ! regulation of myoblast differentiation is_a: GO:0051149 ! positive regulation of muscle cell differentiation relationship: positively_regulates GO:0045445 ! myoblast differentiation [Term] id: GO:0045664 name: regulation of neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] is_a: GO:0050767 ! regulation of neurogenesis relationship: regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045665 name: negative regulation of neuron differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "down regulation of neuron differentiation" EXACT [] synonym: "down-regulation of neuron differentiation" EXACT [] synonym: "downregulation of neuron differentiation" EXACT [] synonym: "inhibition of neuron differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation relationship: negatively_regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045666 name: positive regulation of neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "activation of neuron differentiation" NARROW [] synonym: "stimulation of neuron differentiation" NARROW [] synonym: "up regulation of neuron differentiation" EXACT [] synonym: "up-regulation of neuron differentiation" EXACT [] synonym: "upregulation of neuron differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation relationship: positively_regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045667 name: regulation of osteoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] is_a: GO:0030278 ! regulation of ossification is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0001649 ! osteoblast differentiation [Term] id: GO:0045668 name: negative regulation of osteoblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] synonym: "down regulation of osteoblast differentiation" EXACT [] synonym: "down-regulation of osteoblast differentiation" EXACT [] synonym: "downregulation of osteoblast differentiation" EXACT [] synonym: "inhibition of osteoblast differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045667 ! regulation of osteoblast differentiation relationship: negatively_regulates GO:0001649 ! osteoblast differentiation [Term] id: GO:0045669 name: positive regulation of osteoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] synonym: "activation of osteoblast differentiation" NARROW [] synonym: "stimulation of osteoblast differentiation" NARROW [] synonym: "up regulation of osteoblast differentiation" EXACT [] synonym: "up-regulation of osteoblast differentiation" EXACT [] synonym: "upregulation of osteoblast differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045667 ! regulation of osteoblast differentiation relationship: positively_regulates GO:0001649 ! osteoblast differentiation [Term] id: GO:0045670 name: regulation of osteoclast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation relationship: regulates GO:0030316 ! osteoclast differentiation [Term] id: GO:0045671 name: negative regulation of osteoclast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] synonym: "down regulation of osteoclast differentiation" EXACT [] synonym: "down-regulation of osteoclast differentiation" EXACT [] synonym: "downregulation of osteoclast differentiation" EXACT [] synonym: "inhibition of osteoclast differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045670 ! regulation of osteoclast differentiation relationship: negatively_regulates GO:0030316 ! osteoclast differentiation [Term] id: GO:0045672 name: positive regulation of osteoclast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] synonym: "activation of osteoclast differentiation" NARROW [] synonym: "stimulation of osteoclast differentiation" NARROW [] synonym: "up regulation of osteoclast differentiation" EXACT [] synonym: "up-regulation of osteoclast differentiation" EXACT [] synonym: "upregulation of osteoclast differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045670 ! regulation of osteoclast differentiation relationship: positively_regulates GO:0030316 ! osteoclast differentiation [Term] id: GO:0045676 name: regulation of R7 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0045466 ! R7 cell differentiation [Term] id: GO:0045677 name: negative regulation of R7 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of R7 differentiation" EXACT [] synonym: "down-regulation of R7 differentiation" EXACT [] synonym: "downregulation of R7 differentiation" EXACT [] synonym: "inhibition of R7 differentiation" NARROW [] synonym: "negative regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0045676 ! regulation of R7 cell differentiation is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation relationship: negatively_regulates GO:0045466 ! R7 cell differentiation [Term] id: GO:0045678 name: positive regulation of R7 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of R7 differentiation" NARROW [] synonym: "positive regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of R7 differentiation" NARROW [] synonym: "up regulation of R7 differentiation" EXACT [] synonym: "up-regulation of R7 differentiation" EXACT [] synonym: "upregulation of R7 differentiation" EXACT [] is_a: GO:0045676 ! regulation of R7 cell differentiation is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation relationship: positively_regulates GO:0045466 ! R7 cell differentiation [Term] id: GO:0045679 name: regulation of R8 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of R8 differentiation." [GOC:go_curators] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0045465 ! R8 cell differentiation [Term] id: GO:0045680 name: negative regulation of R8 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of R8 differentiation" EXACT [] synonym: "down-regulation of R8 differentiation" EXACT [] synonym: "downregulation of R8 differentiation" EXACT [] synonym: "inhibition of R8 differentiation" NARROW [] synonym: "negative regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0045679 ! regulation of R8 cell differentiation is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation relationship: negatively_regulates GO:0045465 ! R8 cell differentiation [Term] id: GO:0045681 name: positive regulation of R8 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of R8 differentiation" NARROW [] synonym: "positive regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of R8 differentiation" NARROW [] synonym: "up regulation of R8 differentiation" EXACT [] synonym: "up-regulation of R8 differentiation" EXACT [] synonym: "upregulation of R8 differentiation" EXACT [] is_a: GO:0045679 ! regulation of R8 cell differentiation is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation relationship: positively_regulates GO:0045465 ! R8 cell differentiation [Term] id: GO:0045682 name: regulation of epidermis development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "regulation of epidermal development" EXACT [] synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0008544 ! epidermis development [Term] id: GO:0045683 name: negative regulation of epidermis development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "down regulation of epidermis development" EXACT [] synonym: "down-regulation of epidermis development" EXACT [] synonym: "downregulation of epidermis development" EXACT [] synonym: "inhibition of epidermis development" NARROW [] synonym: "negative regulation of epidermal development" EXACT [] synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0008544 ! epidermis development [Term] id: GO:0045684 name: positive regulation of epidermis development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "activation of epidermis development" NARROW [] synonym: "positive regulation of epidermal development" EXACT [] synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermis development" NARROW [] synonym: "up regulation of epidermis development" EXACT [] synonym: "up-regulation of epidermis development" EXACT [] synonym: "upregulation of epidermis development" EXACT [] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0008544 ! epidermis development [Term] id: GO:0045685 name: regulation of glial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "regulation of glia cell differentiation" EXACT [] synonym: "regulation of neuroglia differentiation" EXACT [] is_a: GO:0014013 ! regulation of gliogenesis relationship: regulates GO:0010001 ! glial cell differentiation [Term] id: GO:0045686 name: negative regulation of glial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "down regulation of glial cell differentiation" EXACT [] synonym: "down-regulation of glial cell differentiation" EXACT [] synonym: "downregulation of glial cell differentiation" EXACT [] synonym: "inhibition of glial cell differentiation" NARROW [] synonym: "negative regulation of glia cell differentiation" EXACT [] synonym: "negative regulation of neuroglia differentiation" EXACT [] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation relationship: negatively_regulates GO:0010001 ! glial cell differentiation [Term] id: GO:0045687 name: positive regulation of glial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "activation of glial cell differentiation" NARROW [] synonym: "positive regulation of glia cell differentiation" EXACT [] synonym: "positive regulation of neuroglia differentiation" EXACT [] synonym: "stimulation of glial cell differentiation" NARROW [] synonym: "up regulation of glial cell differentiation" EXACT [] synonym: "up-regulation of glial cell differentiation" EXACT [] synonym: "upregulation of glial cell differentiation" EXACT [] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation relationship: positively_regulates GO:0010001 ! glial cell differentiation [Term] id: GO:0045688 name: regulation of antipodal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0009557 ! antipodal cell differentiation [Term] id: GO:0045689 name: negative regulation of antipodal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "down regulation of antipodal cell differentiation" EXACT [] synonym: "down-regulation of antipodal cell differentiation" EXACT [] synonym: "downregulation of antipodal cell differentiation" EXACT [] synonym: "inhibition of antipodal cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045688 ! regulation of antipodal cell differentiation relationship: negatively_regulates GO:0009557 ! antipodal cell differentiation [Term] id: GO:0045690 name: positive regulation of antipodal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "activation of antipodal cell differentiation" NARROW [] synonym: "stimulation of antipodal cell differentiation" NARROW [] synonym: "up regulation of antipodal cell differentiation" EXACT [] synonym: "up-regulation of antipodal cell differentiation" EXACT [] synonym: "upregulation of antipodal cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045688 ! regulation of antipodal cell differentiation relationship: positively_regulates GO:0009557 ! antipodal cell differentiation [Term] id: GO:0045691 name: regulation of embryo sac central cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "regulation of female gametophyte central cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0045692 name: negative regulation of embryo sac central cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "down regulation of female gametophyte central cell differentiation" EXACT [] synonym: "down-regulation of female gametophyte central cell differentiation" EXACT [] synonym: "downregulation of female gametophyte central cell differentiation" EXACT [] synonym: "inhibition of female gametophyte central cell differentiation" NARROW [] synonym: "negative regulation of female gametophyte central cell differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045691 ! regulation of embryo sac central cell differentiation relationship: negatively_regulates GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0045693 name: positive regulation of embryo sac central cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "activation of female gametophyte central cell differentiation" NARROW [] synonym: "positive regulation of female gametophyte central cell differentiation" EXACT [] synonym: "stimulation of female gametophyte central cell differentiation" NARROW [] synonym: "up regulation of female gametophyte central cell differentiation" EXACT [] synonym: "up-regulation of female gametophyte central cell differentiation" EXACT [] synonym: "upregulation of female gametophyte central cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045691 ! regulation of embryo sac central cell differentiation relationship: positively_regulates GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0045694 name: regulation of embryo sac egg cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "regulation of female gametophyte egg cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0009560 ! embryo sac egg cell differentiation [Term] id: GO:0045695 name: negative regulation of embryo sac egg cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "down regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "down-regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "downregulation of female gametophyte egg cell differentiation" EXACT [] synonym: "inhibition of female gametophyte egg cell differentiation" NARROW [] synonym: "negative regulation of female gametophyte egg cell differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0009560 ! embryo sac egg cell differentiation [Term] id: GO:0045696 name: positive regulation of embryo sac egg cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "activation of female gametophyte egg cell differentiation" NARROW [] synonym: "positive regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "stimulation of female gametophyte egg cell differentiation" NARROW [] synonym: "up regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "up-regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "upregulation of female gametophyte egg cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0009560 ! embryo sac egg cell differentiation [Term] id: GO:0045697 name: regulation of synergid differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] synonym: "regulation of synergid cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0009563 ! synergid differentiation [Term] id: GO:0045698 name: negative regulation of synergid differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] synonym: "down regulation of synergid differentiation" EXACT [] synonym: "down-regulation of synergid differentiation" EXACT [] synonym: "downregulation of synergid differentiation" EXACT [] synonym: "inhibition of synergid differentiation" NARROW [] synonym: "negative regulation of synergid cell differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045697 ! regulation of synergid differentiation relationship: negatively_regulates GO:0009563 ! synergid differentiation [Term] id: GO:0045699 name: positive regulation of synergid differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] synonym: "activation of synergid differentiation" NARROW [] synonym: "positive regulation of synergid cell differentiation" EXACT [] synonym: "stimulation of synergid differentiation" NARROW [] synonym: "up regulation of synergid differentiation" EXACT [] synonym: "up-regulation of synergid differentiation" EXACT [] synonym: "upregulation of synergid differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045697 ! regulation of synergid differentiation relationship: positively_regulates GO:0009563 ! synergid differentiation [Term] id: GO:0045700 name: regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0045701 name: negative regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] synonym: "down regulation of spermatid nuclear differentiation" EXACT [] synonym: "down-regulation of spermatid nuclear differentiation" EXACT [] synonym: "downregulation of spermatid nuclear differentiation" EXACT [] synonym: "inhibition of spermatid nuclear differentiation" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045700 ! regulation of spermatid nuclear differentiation is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0045702 name: positive regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] synonym: "activation of spermatid nuclear differentiation" NARROW [] synonym: "stimulation of spermatid nuclear differentiation" NARROW [] synonym: "up regulation of spermatid nuclear differentiation" EXACT [] synonym: "up-regulation of spermatid nuclear differentiation" EXACT [] synonym: "upregulation of spermatid nuclear differentiation" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045700 ! regulation of spermatid nuclear differentiation is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0045703 name: ketoreductase activity namespace: molecular_function def: "Catalysis of the reduction of a ketone group to form the corresponding alcohol." [EC:1.1.-.-] xref: EC:1.1.-.- is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0045704 name: regulation of salivary gland boundary specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] synonym: "regulation of salivary gland determination" EXACT [GOC:tb] is_a: GO:0003156 ! regulation of organ formation relationship: regulates GO:0007432 ! salivary gland boundary specification [Term] id: GO:0045705 name: negative regulation of salivary gland boundary specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] synonym: "down regulation of salivary gland determination" EXACT [] synonym: "down-regulation of salivary gland determination" EXACT [] synonym: "downregulation of salivary gland determination" EXACT [] synonym: "inhibition of salivary gland determination" NARROW [] synonym: "negative regulation of salivary gland determination" EXACT [GOC:tb] is_a: GO:0045704 ! regulation of salivary gland boundary specification is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0007432 ! salivary gland boundary specification [Term] id: GO:0045706 name: positive regulation of salivary gland boundary specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] synonym: "activation of salivary gland determination" NARROW [] synonym: "positive regulation of salivary gland determination" EXACT [GOC:tb] synonym: "stimulation of salivary gland determination" NARROW [] synonym: "up regulation of salivary gland determination" EXACT [] synonym: "up-regulation of salivary gland determination" EXACT [] synonym: "upregulation of salivary gland determination" EXACT [] is_a: GO:0045704 ! regulation of salivary gland boundary specification is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0007432 ! salivary gland boundary specification [Term] id: GO:0045707 name: regulation of adult salivary gland boundary specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] synonym: "regulation of adult salivary gland determination" EXACT [GOC:tb] is_a: GO:0045704 ! regulation of salivary gland boundary specification relationship: regulates GO:0007434 ! adult salivary gland boundary specification [Term] id: GO:0045708 name: regulation of larval salivary gland boundary specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] synonym: "regulation of larval salivary gland determination" EXACT [GOC:tb] is_a: GO:0045704 ! regulation of salivary gland boundary specification is_a: GO:0048580 ! regulation of post-embryonic development relationship: regulates GO:0007433 ! larval salivary gland boundary specification [Term] id: GO:0045709 name: negative regulation of adult salivary gland boundary specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] synonym: "down regulation of adult salivary gland determination" EXACT [] synonym: "down-regulation of adult salivary gland determination" EXACT [] synonym: "downregulation of adult salivary gland determination" EXACT [] synonym: "inhibition of adult salivary gland determination" NARROW [] synonym: "negative regulation of adult salivary gland determination" EXACT [GOC:tb] is_a: GO:0045705 ! negative regulation of salivary gland boundary specification is_a: GO:0045707 ! regulation of adult salivary gland boundary specification relationship: negatively_regulates GO:0007434 ! adult salivary gland boundary specification [Term] id: GO:0045710 name: negative regulation of larval salivary gland boundary specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] synonym: "down regulation of larval salivary gland determination" EXACT [] synonym: "down-regulation of larval salivary gland determination" EXACT [] synonym: "downregulation of larval salivary gland determination" EXACT [] synonym: "inhibition of larval salivary gland determination" NARROW [] synonym: "negative regulation of larval salivary gland determination" EXACT [GOC:tb] is_a: GO:0045705 ! negative regulation of salivary gland boundary specification is_a: GO:0045708 ! regulation of larval salivary gland boundary specification relationship: negatively_regulates GO:0007433 ! larval salivary gland boundary specification [Term] id: GO:0045711 name: positive regulation of adult salivary gland boundary specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] synonym: "activation of adult salivary gland determination" NARROW [] synonym: "positive regulation of adult salivary gland determination" EXACT [GOC:tb] synonym: "stimulation of adult salivary gland determination" NARROW [] synonym: "up regulation of adult salivary gland determination" EXACT [] synonym: "up-regulation of adult salivary gland determination" EXACT [] synonym: "upregulation of adult salivary gland determination" EXACT [] is_a: GO:0045706 ! positive regulation of salivary gland boundary specification is_a: GO:0045707 ! regulation of adult salivary gland boundary specification relationship: positively_regulates GO:0007434 ! adult salivary gland boundary specification [Term] id: GO:0045712 name: positive regulation of larval salivary gland boundary specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] synonym: "activation of larval salivary gland determination" NARROW [] synonym: "positive regulation of larval salivary gland determination" EXACT [GOC:tb] synonym: "stimulation of larval salivary gland determination" NARROW [] synonym: "up regulation of larval salivary gland determination" EXACT [] synonym: "up-regulation of larval salivary gland determination" EXACT [] synonym: "upregulation of larval salivary gland determination" EXACT [] is_a: GO:0045706 ! positive regulation of salivary gland boundary specification is_a: GO:0045708 ! regulation of larval salivary gland boundary specification relationship: positively_regulates GO:0007433 ! larval salivary gland boundary specification [Term] id: GO:0045713 name: low-density lipoprotein particle receptor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells." [GOC:go_curators] synonym: "LDLr biosynthesis" EXACT [] synonym: "LDLr biosynthetic process" EXACT [] synonym: "low-density lipoprotein receptor anabolism" EXACT [] synonym: "low-density lipoprotein receptor biosynthesis" EXACT [] synonym: "low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] synonym: "low-density lipoprotein receptor formation" EXACT [] synonym: "low-density lipoprotein receptor synthesis" EXACT [] is_a: GO:0032799 ! low-density lipoprotein receptor particle metabolic process is_a: GO:0032800 ! receptor biosynthetic process [Term] id: GO:0045714 name: regulation of low-density lipoprotein particle receptor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators] synonym: "regulation of LDLr biosynthesis" EXACT [] synonym: "regulation of LDLr biosynthetic process" EXACT [] synonym: "regulation of low-density lipoprotein receptor anabolism" EXACT [] synonym: "regulation of low-density lipoprotein receptor biosynthesis" EXACT [] synonym: "regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] synonym: "regulation of low-density lipoprotein receptor formation" EXACT [] synonym: "regulation of low-density lipoprotein receptor synthesis" EXACT [] is_a: GO:0010869 ! regulation of receptor biosynthetic process relationship: regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process [Term] id: GO:0045715 name: negative regulation of low-density lipoprotein particle receptor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators] synonym: "down regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "down-regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "downregulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "inhibition of low-density lipoprotein receptor biosynthetic process" NARROW [] synonym: "negative regulation of low-density lipoprotein receptor anabolism" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor biosynthesis" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] synonym: "negative regulation of low-density lipoprotein receptor formation" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor synthesis" EXACT [] is_a: GO:0010871 ! negative regulation of receptor biosynthetic process is_a: GO:0045714 ! regulation of low-density lipoprotein particle receptor biosynthetic process relationship: negatively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process [Term] id: GO:0045716 name: positive regulation of low-density lipoprotein particle receptor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators] synonym: "activation of low-density lipoprotein receptor biosynthetic process" NARROW [] synonym: "positive regulation of low-density lipoprotein receptor anabolism" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor biosynthesis" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] synonym: "positive regulation of low-density lipoprotein receptor formation" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor synthesis" EXACT [] synonym: "stimulation of low-density lipoprotein receptor biosynthetic process" NARROW [] synonym: "up regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "up-regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "upregulation of low-density lipoprotein receptor biosynthetic process" EXACT [] is_a: GO:0010870 ! positive regulation of receptor biosynthetic process is_a: GO:0045714 ! regulation of low-density lipoprotein particle receptor biosynthetic process relationship: positively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process [Term] id: GO:0045717 name: negative regulation of fatty acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of fatty acid biosynthetic process" EXACT [] synonym: "down-regulation of fatty acid biosynthetic process" EXACT [] synonym: "downregulation of fatty acid biosynthetic process" EXACT [] synonym: "inhibition of fatty acid biosynthetic process" NARROW [] synonym: "negative regulation of fatty acid anabolism" EXACT [] synonym: "negative regulation of fatty acid biosynthesis" EXACT [] synonym: "negative regulation of fatty acid formation" EXACT [] synonym: "negative regulation of fatty acid synthesis" EXACT [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0045922 ! negative regulation of fatty acid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process relationship: negatively_regulates GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0045718 name: negative regulation of flagellum assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] synonym: "down regulation of flagellum assembly" EXACT [] synonym: "down-regulation of flagellum assembly" EXACT [] synonym: "downregulation of flagellum assembly" EXACT [] synonym: "inhibition of flagellum assembly" NARROW [] synonym: "negative regulation of flagella assembly" EXACT [] synonym: "negative regulation of flagellum biogenesis" RELATED [GOC:mah] is_a: GO:0030092 ! regulation of flagellum assembly is_a: GO:0031345 ! negative regulation of cell projection organization relationship: negatively_regulates GO:0009296 ! flagellum assembly [Term] id: GO:0045719 name: negative regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of glycogen biosynthetic process" EXACT [] synonym: "down-regulation of glycogen biosynthetic process" EXACT [] synonym: "downregulation of glycogen biosynthetic process" EXACT [] synonym: "inhibition of glycogen biosynthetic process" NARROW [] synonym: "negative regulation of glycogen anabolism" EXACT [] synonym: "negative regulation of glycogen biosynthesis" EXACT [] synonym: "negative regulation of glycogen formation" EXACT [] synonym: "negative regulation of glycogen synthesis" EXACT [] is_a: GO:0005979 ! regulation of glycogen biosynthetic process is_a: GO:0070874 ! negative regulation of glycogen metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0005978 ! glycogen biosynthetic process [Term] id: GO:0045720 name: negative regulation of integrin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] synonym: "down regulation of integrin biosynthetic process" EXACT [] synonym: "down-regulation of integrin biosynthetic process" EXACT [] synonym: "downregulation of integrin biosynthetic process" EXACT [] synonym: "inhibition of integrin biosynthetic process" NARROW [] synonym: "negative regulation of integrin anabolism" EXACT [] synonym: "negative regulation of integrin biosynthesis" EXACT [] synonym: "negative regulation of integrin formation" EXACT [] synonym: "negative regulation of integrin synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0045113 ! regulation of integrin biosynthetic process is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0045112 ! integrin biosynthetic process [Term] id: GO:0045721 name: negative regulation of gluconeogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of gluconeogenesis" EXACT [] synonym: "down-regulation of gluconeogenesis" EXACT [] synonym: "downregulation of gluconeogenesis" EXACT [] synonym: "inhibition of gluconeogenesis" NARROW [] is_a: GO:0006111 ! regulation of gluconeogenesis is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process relationship: negatively_regulates GO:0006094 ! gluconeogenesis [Term] id: GO:0045722 name: positive regulation of gluconeogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] subset: gosubset_prok synonym: "activation of gluconeogenesis" NARROW [] synonym: "stimulation of gluconeogenesis" NARROW [] synonym: "up regulation of gluconeogenesis" EXACT [] synonym: "up-regulation of gluconeogenesis" EXACT [] synonym: "upregulation of gluconeogenesis" EXACT [] is_a: GO:0006111 ! regulation of gluconeogenesis is_a: GO:0010907 ! positive regulation of glucose metabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process relationship: positively_regulates GO:0006094 ! gluconeogenesis [Term] id: GO:0045723 name: positive regulation of fatty acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] subset: gosubset_prok synonym: "activation of fatty acid biosynthetic process" NARROW [] synonym: "positive regulation of fatty acid anabolism" EXACT [] synonym: "positive regulation of fatty acid biosynthesis" EXACT [] synonym: "positive regulation of fatty acid formation" EXACT [] synonym: "positive regulation of fatty acid synthesis" EXACT [] synonym: "stimulation of fatty acid biosynthetic process" NARROW [] synonym: "up regulation of fatty acid biosynthetic process" EXACT [] synonym: "up-regulation of fatty acid biosynthetic process" EXACT [] synonym: "upregulation of fatty acid biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0045923 ! positive regulation of fatty acid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process relationship: positively_regulates GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0045724 name: positive regulation of flagellum assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] synonym: "activation of flagellum assembly" NARROW [] synonym: "positive regulation of flagella assembly" EXACT [] synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah] synonym: "stimulation of flagellum assembly" NARROW [] synonym: "up regulation of flagellum assembly" EXACT [] synonym: "up-regulation of flagellum assembly" EXACT [] synonym: "upregulation of flagellum assembly" EXACT [] is_a: GO:0030092 ! regulation of flagellum assembly is_a: GO:0031346 ! positive regulation of cell projection organization relationship: positively_regulates GO:0009296 ! flagellum assembly [Term] id: GO:0045725 name: positive regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] subset: gosubset_prok synonym: "activation of glycogen biosynthetic process" NARROW [] synonym: "positive regulation of glycogen anabolism" EXACT [] synonym: "positive regulation of glycogen biosynthesis" EXACT [] synonym: "positive regulation of glycogen formation" EXACT [] synonym: "positive regulation of glycogen synthesis" EXACT [] synonym: "stimulation of glycogen biosynthetic process" NARROW [] synonym: "up regulation of glycogen biosynthetic process" EXACT [] synonym: "up-regulation of glycogen biosynthetic process" EXACT [] synonym: "upregulation of glycogen biosynthetic process" EXACT [] is_a: GO:0005979 ! regulation of glycogen biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0070875 ! positive regulation of glycogen metabolic process relationship: positively_regulates GO:0005978 ! glycogen biosynthetic process [Term] id: GO:0045726 name: positive regulation of integrin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] synonym: "activation of integrin biosynthetic process" NARROW [] synonym: "positive regulation of integrin anabolism" EXACT [] synonym: "positive regulation of integrin biosynthesis" EXACT [] synonym: "positive regulation of integrin formation" EXACT [] synonym: "positive regulation of integrin synthesis" EXACT [] synonym: "stimulation of integrin biosynthetic process" NARROW [] synonym: "up regulation of integrin biosynthetic process" EXACT [] synonym: "up-regulation of integrin biosynthetic process" EXACT [] synonym: "upregulation of integrin biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0045113 ! regulation of integrin biosynthetic process is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0045112 ! integrin biosynthetic process [Term] id: GO:0045727 name: positive regulation of translation namespace: biological_process alt_id: GO:0045946 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "activation of protein biosynthetic process" NARROW [] synonym: "positive regulation of protein anabolism" EXACT [] synonym: "positive regulation of protein biosynthesis" EXACT [] synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb] synonym: "positive regulation of protein formation" EXACT [] synonym: "positive regulation of protein synthesis" EXACT [] synonym: "stimulation of protein biosynthetic process" NARROW [] synonym: "up regulation of protein biosynthetic process" EXACT [] synonym: "up-regulation of protein biosynthetic process" EXACT [] synonym: "upregulation of protein biosynthetic process" EXACT [] xref: Reactome:110506 "Activated DTOR phosphorylates DS6K" is_a: GO:0006417 ! regulation of translation is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process relationship: positively_regulates GO:0006412 ! translation [Term] id: GO:0045728 name: respiratory burst after phagocytosis namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." [GOC:curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "metabolic burst after phagocytosis" EXACT [] synonym: "oxidative burst after phagocytosis" EXACT [] is_a: GO:0002679 ! respiratory burst involved in defense response [Term] id: GO:0045729 name: respiratory burst at fertilization namespace: biological_process def: "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:2537493, PMID:9013127] synonym: "metabolic burst at fertilization" EXACT [] synonym: "oxidative burst at fertilization" EXACT [] is_a: GO:0045730 ! respiratory burst relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0045730 name: respiratory burst namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "metabolic burst" EXACT [] synonym: "oxidative burst" EXACT [] xref: Wikipedia:Respiratory_burst is_a: GO:0008152 ! metabolic process [Term] id: GO:0045732 name: positive regulation of protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] subset: gosubset_prok synonym: "activation of protein catabolic process" NARROW [] synonym: "positive regulation of protein breakdown" EXACT [] synonym: "positive regulation of protein catabolism" EXACT [] synonym: "positive regulation of protein degradation" EXACT [] synonym: "stimulation of protein catabolic process" NARROW [] synonym: "up regulation of protein catabolic process" EXACT [] synonym: "up-regulation of protein catabolic process" EXACT [] synonym: "upregulation of protein catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process relationship: positively_regulates GO:0030163 ! protein catabolic process [Term] id: GO:0045733 name: acetate catabolic process namespace: biological_process alt_id: GO:0019663 def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [CHEBI:30089, GOC:go_curators] subset: gosubset_prok synonym: "acetate breakdown" EXACT [] synonym: "acetate catabolism" EXACT [] synonym: "acetate degradation" EXACT [] synonym: "homoacetate catabolic process" RELATED [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0045734 name: regulation of acetate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of acetate breakdown" EXACT [] synonym: "regulation of acetate catabolism" EXACT [] synonym: "regulation of acetate degradation" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process relationship: regulates GO:0045733 ! acetate catabolic process [Term] id: GO:0045735 name: nutrient reservoir activity namespace: molecular_function def: "Functions in the storage of nutritious substrates." [GOC:ai] comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'. subset: goslim_pir subset: gosubset_prok synonym: "storage protein" RELATED [] synonym: "storage protein of fat body" RELATED [] synonym: "yolk protein" RELATED [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0045736 name: negative regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of CDK activity." [GOC:go_curators] synonym: "CDK inhibitor" RELATED [] synonym: "cyclin-dependent kinase inhibitor" RELATED [] synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "inhibition of cyclin-dependent protein kinase activity" NARROW [] synonym: "negative regulation of CDK activity" EXACT [] is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity [Term] id: GO:0045737 name: positive regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators] synonym: "activation of cyclin-dependent protein kinase activity" NARROW [] synonym: "positive regulation of CDK activity" EXACT [] synonym: "stimulation of cyclin-dependent protein kinase activity" NARROW [] synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT [] is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity [Term] id: GO:0045738 name: negative regulation of DNA repair namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of DNA repair" EXACT [] synonym: "down-regulation of DNA repair" EXACT [] synonym: "downregulation of DNA repair" EXACT [] synonym: "inhibition of DNA repair" NARROW [] is_a: GO:0006282 ! regulation of DNA repair is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051053 ! negative regulation of DNA metabolic process relationship: negatively_regulates GO:0006281 ! DNA repair [Term] id: GO:0045739 name: positive regulation of DNA repair namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators] subset: gosubset_prok synonym: "activation of DNA repair" NARROW [] synonym: "stimulation of DNA repair" NARROW [] synonym: "up regulation of DNA repair" EXACT [] synonym: "up-regulation of DNA repair" EXACT [] synonym: "upregulation of DNA repair" EXACT [] is_a: GO:0006282 ! regulation of DNA repair is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051054 ! positive regulation of DNA metabolic process relationship: positively_regulates GO:0006281 ! DNA repair [Term] id: GO:0045740 name: positive regulation of DNA replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators] subset: gosubset_prok synonym: "activation of DNA replication" NARROW [] synonym: "stimulation of DNA replication" NARROW [] synonym: "up regulation of DNA replication" EXACT [] synonym: "up-regulation of DNA replication" EXACT [] synonym: "upregulation of DNA replication" EXACT [] is_a: GO:0006275 ! regulation of DNA replication is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051054 ! positive regulation of DNA metabolic process relationship: positively_regulates GO:0006260 ! DNA replication [Term] id: GO:0045741 name: positive regulation of epidermal growth factor receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor activity." [GOC:go_curators] synonym: "activation of epidermal growth factor receptor activity" NARROW [] synonym: "positive regulation of EGF receptor activity" EXACT [] synonym: "positive regulation of EGFR activity" EXACT [] synonym: "stimulation of epidermal growth factor receptor activity" NARROW [] synonym: "up regulation of epidermal growth factor receptor activity" EXACT [] synonym: "up-regulation of epidermal growth factor receptor activity" EXACT [] synonym: "upregulation of epidermal growth factor receptor activity" EXACT [] is_a: GO:0007176 ! regulation of epidermal growth factor receptor activity is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity is_a: GO:2000273 ! positive regulation of receptor activity [Term] id: GO:0045742 name: positive regulation of epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of epidermal growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of EGF receptor signaling pathway" EXACT [] synonym: "positive regulation of EGF receptor signalling pathway" EXACT [] synonym: "positive regulation of EGFR signaling pathway" EXACT [] synonym: "stimulation of epidermal growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of epidermal growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway relationship: positively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0045743 name: positive regulation of fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of fibroblast growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of FGF receptor signaling pathway" EXACT [] synonym: "positive regulation of FGF receptor signalling pathway" EXACT [] synonym: "positive regulation of FGFR signaling pathway" EXACT [] synonym: "stimulation of fibroblast growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of fibroblast growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway relationship: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0045744 name: negative regulation of G-protein coupled receptor protein signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators] synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of GPCR protein signaling pathway" EXACT [] synonym: "negative regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0045745 name: positive regulation of G-protein coupled receptor protein signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators] synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of GPCR protein signaling pathway" EXACT [] synonym: "positive regulation of GPCR protein signalling pathway" EXACT [] synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0045746 name: negative regulation of Notch signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] synonym: "down regulation of Notch signaling pathway" EXACT [] synonym: "down-regulation of Notch signaling pathway" EXACT [] synonym: "downregulation of Notch signaling pathway" EXACT [] synonym: "inhibition of Notch signaling pathway" NARROW [] synonym: "negative regulation of N signaling pathway" EXACT [] synonym: "negative regulation of N signalling pathway" EXACT [] synonym: "negative regulation of Notch signalling pathway" EXACT [] is_a: GO:0008593 ! regulation of Notch signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0007219 ! Notch signaling pathway [Term] id: GO:0045747 name: positive regulation of Notch signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] synonym: "activation of Notch signaling pathway" NARROW [] synonym: "positive regulation of N signaling pathway" EXACT [] synonym: "positive regulation of N signalling pathway" EXACT [] synonym: "positive regulation of Notch signalling pathway" EXACT [] synonym: "stimulation of Notch signaling pathway" NARROW [] synonym: "up regulation of Notch signaling pathway" EXACT [] synonym: "up-regulation of Notch signaling pathway" EXACT [] synonym: "upregulation of Notch signaling pathway" EXACT [] is_a: GO:0008593 ! regulation of Notch signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0007219 ! Notch signaling pathway [Term] id: GO:0045748 name: positive regulation of R8 cell spacing in compound eye namespace: biological_process def: "Any process that activates or enforces the correct R8 cell spacing in a compound eye." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of R8 spacing" NARROW [] synonym: "positive regulation of R8 spacing" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of R8 spacing" NARROW [] synonym: "up regulation of R8 spacing" EXACT [] synonym: "up-regulation of R8 spacing" EXACT [] synonym: "upregulation of R8 spacing" EXACT [] is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye [Term] id: GO:0045749 name: negative regulation of S phase of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] synonym: "down regulation of S phase of mitotic cell cycle" EXACT [] synonym: "down-regulation of S phase of mitotic cell cycle" EXACT [] synonym: "downregulation of S phase of mitotic cell cycle" EXACT [] synonym: "inhibition of S phase of mitotic cell cycle" NARROW [] synonym: "negative regulation of S-phase of mitotic cell cycle" EXACT [] is_a: GO:0007090 ! regulation of S phase of mitotic cell cycle is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle relationship: negatively_regulates GO:0000084 ! S phase of mitotic cell cycle [Term] id: GO:0045750 name: positive regulation of S phase of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] synonym: "activation of S phase of mitotic cell cycle" NARROW [] synonym: "positive regulation of S-phase of mitotic cell cycle" EXACT [] synonym: "stimulation of S phase of mitotic cell cycle" NARROW [] synonym: "up regulation of S phase of mitotic cell cycle" EXACT [] synonym: "up-regulation of S phase of mitotic cell cycle" EXACT [] synonym: "upregulation of S phase of mitotic cell cycle" EXACT [] is_a: GO:0007090 ! regulation of S phase of mitotic cell cycle is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0000084 ! S phase of mitotic cell cycle [Term] id: GO:0045751 name: negative regulation of Toll signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] synonym: "down regulation of Toll signaling pathway" EXACT [] synonym: "down-regulation of Toll signaling pathway" EXACT [] synonym: "downregulation of Toll signaling pathway" EXACT [] synonym: "inhibition of Toll signaling pathway" NARROW [] synonym: "negative regulation of Tl signaling pathway" EXACT [] synonym: "negative regulation of Tl signalling pathway" EXACT [] is_a: GO:0008592 ! regulation of Toll signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0008063 ! Toll signaling pathway [Term] id: GO:0045752 name: positive regulation of Toll signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] synonym: "activation of Toll signaling pathway" NARROW [] synonym: "positive regulation of Tl signaling pathway" EXACT [] synonym: "positive regulation of Tl signalling pathway" EXACT [] synonym: "stimulation of Toll signaling pathway" NARROW [] synonym: "up regulation of Toll signaling pathway" EXACT [] synonym: "up-regulation of Toll signaling pathway" EXACT [] synonym: "upregulation of Toll signaling pathway" EXACT [] is_a: GO:0008592 ! regulation of Toll signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0008063 ! Toll signaling pathway [Term] id: GO:0045753 name: negative regulation of acetate catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of acetate catabolic process" EXACT [] synonym: "down-regulation of acetate catabolic process" EXACT [] synonym: "downregulation of acetate catabolic process" EXACT [] synonym: "inhibition of acetate catabolic process" NARROW [] synonym: "negative regulation of acetate breakdown" EXACT [] synonym: "negative regulation of acetate catabolism" EXACT [] synonym: "negative regulation of acetate degradation" EXACT [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045734 ! regulation of acetate catabolic process relationship: negatively_regulates GO:0045733 ! acetate catabolic process [Term] id: GO:0045754 name: positive regulation of acetate catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] subset: gosubset_prok synonym: "activation of acetate catabolic process" NARROW [] synonym: "positive regulation of acetate breakdown" EXACT [] synonym: "positive regulation of acetate catabolism" EXACT [] synonym: "positive regulation of acetate degradation" EXACT [] synonym: "stimulation of acetate catabolic process" NARROW [] synonym: "up regulation of acetate catabolic process" EXACT [] synonym: "up-regulation of acetate catabolic process" EXACT [] synonym: "upregulation of acetate catabolic process" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045734 ! regulation of acetate catabolic process relationship: positively_regulates GO:0045733 ! acetate catabolic process [Term] id: GO:0045755 name: negative regulation of initiation of acetate catabolic process by acetate namespace: biological_process def: "Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "down-regulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "downregulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "inhibition of initiation of acetate catabolic process by acetate" NARROW [] synonym: "negative regulation of initiation of acetate breakdown by acetate" EXACT [] synonym: "negative regulation of initiation of acetate degradation by acetate" EXACT [] is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate [Term] id: GO:0045756 name: positive regulation of initiation of acetate catabolic process by acetate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] subset: gosubset_prok synonym: "activation of initiation of acetate catabolic process by acetate" NARROW [] synonym: "positive regulation of initiation of acetate breakdown by acetate" EXACT [] synonym: "positive regulation of initiation of acetate degradation by acetate" EXACT [] synonym: "stimulation of initiation of acetate catabolic process by acetate" NARROW [] synonym: "up regulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "up-regulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "upregulation of initiation of acetate catabolic process by acetate" EXACT [] is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate [Term] id: GO:0045757 name: negative regulation of actin polymerization and/or depolymerization namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators] comment: This term was made obsolete because it has been split. is_obsolete: true consider: GO:0030835 consider: GO:0030837 [Term] id: GO:0045758 name: positive regulation of actin polymerization and/or depolymerization namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators] comment: This term was made obsolete because it has been split. is_obsolete: true consider: GO:0030836 consider: GO:0030838 [Term] id: GO:0045759 name: negative regulation of action potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:go_curators] synonym: "down regulation of action potential" EXACT [] synonym: "down-regulation of action potential" EXACT [] synonym: "downregulation of action potential" EXACT [] synonym: "inhibition of action potential" NARROW [] is_a: GO:0001508 ! regulation of action potential [Term] id: GO:0045760 name: positive regulation of action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:go_curators] synonym: "activation of action potential" NARROW [] synonym: "stimulation of action potential" NARROW [] synonym: "up regulation of action potential" EXACT [] synonym: "up-regulation of action potential" EXACT [] synonym: "upregulation of action potential" EXACT [] is_a: GO:0001508 ! regulation of action potential [Term] id: GO:0045761 name: regulation of adenylate cyclase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] synonym: "adenylate cyclase regulator" RELATED [] synonym: "regulation of adenylyl cyclase activity" EXACT [] is_a: GO:0030817 ! regulation of cAMP biosynthetic process is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0051339 ! regulation of lyase activity [Term] id: GO:0045762 name: positive regulation of adenylate cyclase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] synonym: "adenylate cyclase activator" RELATED [] synonym: "positive regulation of adenylyl cyclase activity" EXACT [] synonym: "stimulation of adenylate cyclase activity" NARROW [] synonym: "up regulation of adenylate cyclase activity" EXACT [] synonym: "up-regulation of adenylate cyclase activity" EXACT [] synonym: "upregulation of adenylate cyclase activity" EXACT [] is_a: GO:0031281 ! positive regulation of cyclase activity is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0051349 ! positive regulation of lyase activity [Term] id: GO:0045763 name: negative regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of amino acid metabolic process" EXACT [] synonym: "down-regulation of amino acid metabolic process" EXACT [] synonym: "downregulation of amino acid metabolic process" EXACT [] synonym: "inhibition of amino acid metabolic process" NARROW [] synonym: "negative regulation of amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0033239 ! negative regulation of cellular amine metabolic process relationship: negatively_regulates GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0045764 name: positive regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] subset: gosubset_prok synonym: "activation of amino acid metabolic process" NARROW [] synonym: "positive regulation of amino acid metabolism" EXACT [] synonym: "stimulation of amino acid metabolic process" NARROW [] synonym: "up regulation of amino acid metabolic process" EXACT [] synonym: "up-regulation of amino acid metabolic process" EXACT [] synonym: "upregulation of amino acid metabolic process" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0033240 ! positive regulation of cellular amine metabolic process relationship: positively_regulates GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0045765 name: regulation of angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0001525 ! angiogenesis [Term] id: GO:0045766 name: positive regulation of angiogenesis namespace: biological_process def: "Any process that activates or increases angiogenesis." [GOC:go_curators] synonym: "activation of angiogenesis" NARROW [] synonym: "stimulation of angiogenesis" NARROW [] synonym: "up regulation of angiogenesis" EXACT [] synonym: "up-regulation of angiogenesis" EXACT [] synonym: "upregulation of angiogenesis" EXACT [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0001525 ! angiogenesis [Term] id: GO:0045767 name: regulation of anti-apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anti-apoptosis." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0006916 ! anti-apoptosis [Term] id: GO:0045768 name: positive regulation of anti-apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anti-apoptosis." [GOC:go_curators] synonym: "activation of anti-apoptosis" NARROW [] synonym: "stimulation of anti-apoptosis" NARROW [] synonym: "up regulation of anti-apoptosis" EXACT [] synonym: "up-regulation of anti-apoptosis" EXACT [] synonym: "upregulation of anti-apoptosis" EXACT [] is_a: GO:0045767 ! regulation of anti-apoptosis is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0006916 ! anti-apoptosis [Term] id: GO:0045769 name: negative regulation of asymmetric cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "down regulation of asymmetric cell division" EXACT [] synonym: "down-regulation of asymmetric cell division" EXACT [] synonym: "downregulation of asymmetric cell division" EXACT [] synonym: "inhibition of asymmetric cell division" NARROW [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051782 ! negative regulation of cell division relationship: negatively_regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0045770 name: positive regulation of asymmetric cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "activation of asymmetric cell division" NARROW [] synonym: "stimulation of asymmetric cell division" NARROW [] synonym: "up regulation of asymmetric cell division" EXACT [] synonym: "up-regulation of asymmetric cell division" EXACT [] synonym: "upregulation of asymmetric cell division" EXACT [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051781 ! positive regulation of cell division relationship: positively_regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0045771 name: negative regulation of autophagic vacuole size namespace: biological_process def: "Any process that reduces autophagic vacuole size." [GOC:go_curators] synonym: "down regulation of autophagic vacuole size" EXACT [] synonym: "down-regulation of autophagic vacuole size" EXACT [] synonym: "downregulation of autophagic vacuole size" EXACT [] synonym: "inhibition of autophagic vacuole size" NARROW [] is_a: GO:0016243 ! regulation of autophagic vacuole size [Term] id: GO:0045772 name: positive regulation of autophagic vacuole size namespace: biological_process def: "Any process that increases autophagic vacuole size." [GOC:go_curators] synonym: "activation of autophagic vacuole size" NARROW [] synonym: "stimulation of autophagic vacuole size" NARROW [] synonym: "up regulation of autophagic vacuole size" EXACT [] synonym: "up-regulation of autophagic vacuole size" EXACT [] synonym: "upregulation of autophagic vacuole size" EXACT [] is_a: GO:0016243 ! regulation of autophagic vacuole size [Term] id: GO:0045773 name: positive regulation of axon extension namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators] synonym: "activation of axon extension" NARROW [] synonym: "stimulation of axon extension" NARROW [] synonym: "up regulation of axon extension" EXACT [] synonym: "up-regulation of axon extension" EXACT [] synonym: "upregulation of axon extension" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0050772 ! positive regulation of axonogenesis relationship: positively_regulates GO:0048675 ! axon extension [Term] id: GO:0045774 name: negative regulation of beta 2 integrin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] synonym: "down regulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "down-regulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "downregulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "inhibition of beta 2 integrin biosynthetic process" NARROW [] synonym: "negative regulation of beta 2 integrin anabolism" EXACT [] synonym: "negative regulation of beta 2 integrin biosynthesis" EXACT [] synonym: "negative regulation of beta 2 integrin formation" EXACT [] synonym: "negative regulation of beta 2 integrin synthesis" EXACT [] is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process is_a: GO:0045720 ! negative regulation of integrin biosynthetic process relationship: negatively_regulates GO:0045114 ! beta 2 integrin biosynthetic process [Term] id: GO:0045775 name: positive regulation of beta 2 integrin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] synonym: "activation of beta 2 integrin biosynthetic process" NARROW [] synonym: "positive regulation of beta 2 integrin anabolism" EXACT [] synonym: "positive regulation of beta 2 integrin biosynthesis" EXACT [] synonym: "positive regulation of beta 2 integrin formation" EXACT [] synonym: "positive regulation of beta 2 integrin synthesis" EXACT [] synonym: "stimulation of beta 2 integrin biosynthetic process" NARROW [] synonym: "up regulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "up-regulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "upregulation of beta 2 integrin biosynthetic process" EXACT [] is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process is_a: GO:0045726 ! positive regulation of integrin biosynthetic process relationship: positively_regulates GO:0045114 ! beta 2 integrin biosynthetic process [Term] id: GO:0045776 name: negative regulation of blood pressure namespace: biological_process def: "Any process in which the force of blood traveling through the circulatory system is decreased." [GOC:go_curators, GOC:mtg_cardio] synonym: "down regulation of blood pressure" EXACT [] synonym: "down-regulation of blood pressure" EXACT [] synonym: "downregulation of blood pressure" EXACT [] synonym: "inhibition of blood pressure" NARROW [] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0045777 name: positive regulation of blood pressure namespace: biological_process def: "Any process in which the force of blood traveling through the circulatory system is increased." [GOC:go_curators, GOC:mtg_cardio] synonym: "activation of blood pressure" NARROW [] synonym: "stimulation of blood pressure" NARROW [] synonym: "up regulation of blood pressure" EXACT [] synonym: "up-regulation of blood pressure" EXACT [] synonym: "upregulation of blood pressure" EXACT [] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0045778 name: positive regulation of ossification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone formation." [GOC:go_curators] synonym: "activation of ossification" NARROW [] synonym: "positive regulation of bone biosynthesis" EXACT [] synonym: "positive regulation of bone formation" EXACT [] synonym: "stimulation of ossification" NARROW [] synonym: "up regulation of ossification" EXACT [] synonym: "up-regulation of ossification" EXACT [] synonym: "upregulation of ossification" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0001503 ! ossification [Term] id: GO:0045779 name: negative regulation of bone resorption namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators] synonym: "down regulation of bone resorption" EXACT [] synonym: "down-regulation of bone resorption" EXACT [] synonym: "downregulation of bone resorption" EXACT [] synonym: "inhibition of bone resorption" NARROW [] is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0045124 ! regulation of bone resorption is_a: GO:0046851 ! negative regulation of bone remodeling relationship: negatively_regulates GO:0045453 ! bone resorption [Term] id: GO:0045780 name: positive regulation of bone resorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators] synonym: "activation of bone resorption" NARROW [] synonym: "stimulation of bone resorption" NARROW [] synonym: "up regulation of bone resorption" EXACT [] synonym: "up-regulation of bone resorption" EXACT [] synonym: "upregulation of bone resorption" EXACT [] is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0045124 ! regulation of bone resorption is_a: GO:0046852 ! positive regulation of bone remodeling relationship: positively_regulates GO:0045453 ! bone resorption [Term] id: GO:0045781 name: negative regulation of cell budding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell budding." [GOC:go_curators] synonym: "down regulation of cell budding" EXACT [] synonym: "down-regulation of cell budding" EXACT [] synonym: "downregulation of cell budding" EXACT [] synonym: "inhibition of cell budding" NARROW [] synonym: "negative regulation of budding" BROAD [] is_a: GO:0007116 ! regulation of cell budding is_a: GO:0051782 ! negative regulation of cell division relationship: negatively_regulates GO:0007114 ! cell budding [Term] id: GO:0045782 name: positive regulation of cell budding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell budding." [GOC:go_curators] synonym: "activation of cell budding" NARROW [] synonym: "positive regulation of budding" BROAD [] synonym: "stimulation of cell budding" NARROW [] synonym: "up regulation of cell budding" EXACT [] synonym: "up-regulation of cell budding" EXACT [] synonym: "upregulation of cell budding" EXACT [] is_a: GO:0007116 ! regulation of cell budding is_a: GO:0051781 ! positive regulation of cell division relationship: positively_regulates GO:0007114 ! cell budding [Term] id: GO:0045783 name: negative regulation of calcium in ER namespace: biological_process def: "OBSOLETE. Any process that reduces the concentration of calcium in the ER." [GOC:go_curators] comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). is_obsolete: true consider: GO:0005783 consider: GO:0006874 [Term] id: GO:0045784 name: positive regulation of calcium in ER namespace: biological_process def: "OBSOLETE. Any process that increases the concentration of calcium in the ER." [GOC:go_curators] comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). is_obsolete: true consider: GO:0005783 consider: GO:0006874 [Term] id: GO:0045785 name: positive regulation of cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "activation of cell adhesion" NARROW [] synonym: "stimulation of cell adhesion" NARROW [] synonym: "up regulation of cell adhesion" EXACT [] synonym: "up-regulation of cell adhesion" EXACT [] synonym: "upregulation of cell adhesion" EXACT [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0045786 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] xref: Reactome:1253483 "p75NTR negatively regulates cell cycle via SC1" xref: Reactome:1280419 "p75NTR negatively regulates cell cycle via SC1" xref: Reactome:1299255 "p75NTR negatively regulates cell cycle via SC1" xref: Reactome:1326999 "p75NTR negatively regulates cell cycle via SC1" xref: Reactome:1353094 "p75NTR negatively regulates cell cycle via SC1" xref: Reactome:1373282 "p75NTR negatively regulates cell cycle via SC1" xref: Reactome:1393297 "p75NTR negatively regulates cell cycle via SC1" xref: Reactome:1417795 "p75NTR negatively regulates cell cycle via SC1" xref: Reactome:1450895 "p75NTR negatively regulates cell cycle via SC1" xref: Reactome:193670 "p75NTR negatively regulates cell cycle via SC1" is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle relationship: negatively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045787 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle relationship: positively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045792 name: negative regulation of cell size namespace: biological_process def: "Any process that reduces cell size." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of cell size" EXACT [] synonym: "down-regulation of cell size" EXACT [] synonym: "downregulation of cell size" EXACT [] synonym: "inhibition of cell size" NARROW [] is_a: GO:0008361 ! regulation of cell size [Term] id: GO:0045793 name: positive regulation of cell size namespace: biological_process def: "Any process that increases cell size." [GOC:go_curators] subset: gosubset_prok synonym: "activation of cell size" NARROW [] synonym: "stimulation of cell size" NARROW [] synonym: "up regulation of cell size" EXACT [] synonym: "up-regulation of cell size" EXACT [] synonym: "upregulation of cell size" EXACT [] xref: Reactome:110468 "Activation of DAkt1 by DPDK1" is_a: GO:0008361 ! regulation of cell size [Term] id: GO:0045794 name: negative regulation of cell volume namespace: biological_process def: "Any process that decreases cell volume." [GOC:go_curators] synonym: "cell regulatory volume decrease" RELATED [PMID:12388065] synonym: "RVD" RELATED [PMID:12388065] is_a: GO:0006884 ! cell volume homeostasis [Term] id: GO:0045795 name: positive regulation of cell volume namespace: biological_process def: "Any process that increases cell volume." [GOC:go_curators] is_a: GO:0006884 ! cell volume homeostasis [Term] id: GO:0045796 name: negative regulation of intestinal cholesterol absorption namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators] synonym: "down regulation of cholesterol absorption" EXACT [] synonym: "down-regulation of cholesterol absorption" EXACT [] synonym: "downregulation of cholesterol absorption" EXACT [] synonym: "inhibition of cholesterol absorption" NARROW [] is_a: GO:0030300 ! regulation of intestinal cholesterol absorption is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:0060457 ! negative regulation of digestive system process relationship: negatively_regulates GO:0030299 ! intestinal cholesterol absorption [Term] id: GO:0045797 name: positive regulation of intestinal cholesterol absorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators] synonym: "activation of cholesterol absorption" NARROW [] synonym: "stimulation of cholesterol absorption" NARROW [] synonym: "up regulation of cholesterol absorption" EXACT [] synonym: "up-regulation of cholesterol absorption" EXACT [] synonym: "upregulation of cholesterol absorption" EXACT [] is_a: GO:0030300 ! regulation of intestinal cholesterol absorption is_a: GO:0032376 ! positive regulation of cholesterol transport is_a: GO:0060456 ! positive regulation of digestive system process relationship: positively_regulates GO:0030299 ! intestinal cholesterol absorption [Term] id: GO:0045798 name: negative regulation of chromatin assembly or disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] synonym: "down regulation of chromatin assembly or disassembly" EXACT [] synonym: "down-regulation of chromatin assembly or disassembly" EXACT [] synonym: "downregulation of chromatin assembly or disassembly" EXACT [] synonym: "inhibition of chromatin assembly or disassembly" NARROW [] synonym: "negative regulation of chromatin assembly/disassembly" EXACT [] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly is_a: GO:0010639 ! negative regulation of organelle organization relationship: negatively_regulates GO:0006333 ! chromatin assembly or disassembly [Term] id: GO:0045799 name: positive regulation of chromatin assembly or disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] synonym: "activation of chromatin assembly or disassembly" NARROW [] synonym: "positive regulation of chromatin assembly/disassembly" EXACT [] synonym: "stimulation of chromatin assembly or disassembly" NARROW [] synonym: "up regulation of chromatin assembly or disassembly" EXACT [] synonym: "up-regulation of chromatin assembly or disassembly" EXACT [] synonym: "upregulation of chromatin assembly or disassembly" EXACT [] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly is_a: GO:0010638 ! positive regulation of organelle organization relationship: positively_regulates GO:0006333 ! chromatin assembly or disassembly [Term] id: GO:0045800 name: negative regulation of chitin-based cuticle tanning namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] synonym: "down regulation of cuticle tanning" EXACT [] synonym: "down-regulation of cuticle tanning" EXACT [] synonym: "downregulation of cuticle tanning" EXACT [] synonym: "inhibition of cuticle tanning" NARROW [] synonym: "negative regulation of cuticle hardening" NARROW [] synonym: "negative regulation of cuticle tanning" EXACT [] is_a: GO:0007564 ! regulation of chitin-based cuticle tanning is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0007593 ! chitin-based cuticle tanning [Term] id: GO:0045801 name: positive regulation of chitin-based cuticle tanning namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] synonym: "activation of cuticle tanning" NARROW [] synonym: "positive regulation of cuticle hardening" NARROW [] synonym: "positive regulation of cuticle tanning" EXACT [] synonym: "stimulation of cuticle tanning" NARROW [] synonym: "up regulation of cuticle tanning" EXACT [] synonym: "up-regulation of cuticle tanning" EXACT [] synonym: "upregulation of cuticle tanning" EXACT [] is_a: GO:0007564 ! regulation of chitin-based cuticle tanning is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0007593 ! chitin-based cuticle tanning [Term] id: GO:0045802 name: negative regulation of cytoskeleton namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense. is_obsolete: true consider: GO:0007010 [Term] id: GO:0045803 name: positive regulation of cytoskeleton namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense. is_obsolete: true consider: GO:0007010 [Term] id: GO:0045804 name: negative regulation of eclosion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion." [GOC:go_curators] synonym: "down regulation of eclosion" EXACT [] synonym: "down-regulation of eclosion" EXACT [] synonym: "downregulation of eclosion" EXACT [] synonym: "inhibition of eclosion" NARROW [] is_a: GO:0007563 ! regulation of eclosion is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0007562 ! eclosion [Term] id: GO:0045805 name: positive regulation of eclosion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eclosion." [GOC:go_curators] synonym: "activation of eclosion" NARROW [] synonym: "stimulation of eclosion" NARROW [] synonym: "up regulation of eclosion" EXACT [] synonym: "up-regulation of eclosion" EXACT [] synonym: "upregulation of eclosion" EXACT [] is_a: GO:0007563 ! regulation of eclosion is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0007562 ! eclosion [Term] id: GO:0045806 name: negative regulation of endocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "down regulation of endocytosis" EXACT [] synonym: "down-regulation of endocytosis" EXACT [] synonym: "downregulation of endocytosis" EXACT [] synonym: "inhibition of endocytosis" NARROW [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0006897 ! endocytosis [Term] id: GO:0045807 name: positive regulation of endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "activation of endocytosis" NARROW [] synonym: "stimulation of endocytosis" NARROW [] synonym: "up regulation of endocytosis" EXACT [] synonym: "up-regulation of endocytosis" EXACT [] synonym: "upregulation of endocytosis" EXACT [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0006897 ! endocytosis [Term] id: GO:0045808 name: negative regulation of establishment of competence for transformation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of establishment of competence for transformation" EXACT [] synonym: "down-regulation of establishment of competence for transformation" EXACT [] synonym: "downregulation of establishment of competence for transformation" EXACT [] synonym: "inhibition of establishment of competence for transformation" NARROW [] synonym: "inhibitor of the establishment of competence for transformation activity" RELATED [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032105 ! negative regulation of response to extracellular stimulus is_a: GO:0045304 ! regulation of establishment of competence for transformation relationship: negatively_regulates GO:0030420 ! establishment of competence for transformation [Term] id: GO:0045809 name: positive regulation of establishment of competence for transformation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators] synonym: "activation of establishment of competence for transformation" NARROW [] synonym: "activator of the establishment of competence for transformation activity" RELATED [] synonym: "stimulation of establishment of competence for transformation" NARROW [] synonym: "up regulation of establishment of competence for transformation" EXACT [] synonym: "up-regulation of establishment of competence for transformation" EXACT [] synonym: "upregulation of establishment of competence for transformation" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0032106 ! positive regulation of response to extracellular stimulus is_a: GO:0045304 ! regulation of establishment of competence for transformation relationship: positively_regulates GO:0030420 ! establishment of competence for transformation [Term] id: GO:0045812 name: negative regulation of Wnt receptor signaling pathway, calcium modulating pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of frizzled-2 signaling pathway" EXACT [] synonym: "down-regulation of frizzled-2 signaling pathway" EXACT [] synonym: "downregulation of frizzled-2 signaling pathway" EXACT [] synonym: "inhibition of frizzled-2 signaling pathway" NARROW [] synonym: "negative regulation of frizzled-2 signaling pathway" EXACT [] synonym: "negative regulation of frizzled-2 signalling pathway" EXACT [] is_a: GO:0008591 ! regulation of Wnt receptor signaling pathway, calcium modulating pathway is_a: GO:2000051 ! negative regulation of non-canonical Wnt receptor signaling pathway relationship: negatively_regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway [Term] id: GO:0045813 name: positive regulation of Wnt receptor signaling pathway, calcium modulating pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the frizzled-2 signaling pathway." [GOC:go_curators] synonym: "activation of frizzled-2 signaling pathway" NARROW [] synonym: "positive regulation of frizzled-2 signaling pathway" EXACT [] synonym: "positive regulation of frizzled-2 signalling pathway" EXACT [] synonym: "stimulation of frizzled-2 signaling pathway" NARROW [] synonym: "up regulation of frizzled-2 signaling pathway" EXACT [] synonym: "up-regulation of frizzled-2 signaling pathway" EXACT [] synonym: "upregulation of frizzled-2 signaling pathway" EXACT [] is_a: GO:0008591 ! regulation of Wnt receptor signaling pathway, calcium modulating pathway is_a: GO:2000052 ! positive regulation of non-canonical Wnt receptor signaling pathway relationship: positively_regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway [Term] id: GO:0045814 name: negative regulation of gene expression, epigenetic namespace: biological_process def: "Any epigenetic process that stops, prevents or reduces the rate of gene expression." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of gene expression, epigenetic" EXACT [] synonym: "down-regulation of gene expression, epigenetic" EXACT [] synonym: "downregulation of gene expression, epigenetic" EXACT [] synonym: "inhibition of gene expression, epigenetic" NARROW [] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0045815 name: positive regulation of gene expression, epigenetic namespace: biological_process def: "Any epigenetic process that activates or increases the rate of gene expression." [GOC:go_curators] synonym: "activation of gene expression, epigenetic" NARROW [] synonym: "stimulation of gene expression, epigenetic" NARROW [] synonym: "up regulation of gene expression, epigenetic" EXACT [] synonym: "up-regulation of gene expression, epigenetic" EXACT [] synonym: "upregulation of gene expression, epigenetic" EXACT [] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0045818 name: negative regulation of glycogen catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of glycogen catabolic process" EXACT [] synonym: "down-regulation of glycogen catabolic process" EXACT [] synonym: "downregulation of glycogen catabolic process" EXACT [] synonym: "inhibition of glycogen catabolic process" NARROW [] synonym: "negative regulation of glycogen breakdown" EXACT [] synonym: "negative regulation of glycogen catabolism" EXACT [] synonym: "negative regulation of glycogen degradation" EXACT [] synonym: "negative regulation of glycogenolysis" EXACT [GOC:sl] is_a: GO:0005981 ! regulation of glycogen catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0070874 ! negative regulation of glycogen metabolic process relationship: negatively_regulates GO:0005980 ! glycogen catabolic process [Term] id: GO:0045819 name: positive regulation of glycogen catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] subset: gosubset_prok synonym: "activation of glycogen catabolic process" NARROW [] synonym: "positive regulation of glycogen breakdown" EXACT [] synonym: "positive regulation of glycogen catabolism" EXACT [] synonym: "positive regulation of glycogen degradation" EXACT [] synonym: "positive regulation of glycogenolysis" EXACT [GOC:sl] synonym: "stimulation of glycogen catabolic process" NARROW [] synonym: "up regulation of glycogen catabolic process" EXACT [] synonym: "up-regulation of glycogen catabolic process" EXACT [] synonym: "upregulation of glycogen catabolic process" EXACT [] is_a: GO:0005981 ! regulation of glycogen catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0070875 ! positive regulation of glycogen metabolic process relationship: positively_regulates GO:0005980 ! glycogen catabolic process [Term] id: GO:0045820 name: negative regulation of glycolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of glycolysis" EXACT [] synonym: "down-regulation of glycolysis" EXACT [] synonym: "downregulation of glycolysis" EXACT [] synonym: "inhibition of glycolysis" NARROW [] is_a: GO:0006110 ! regulation of glycolysis is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process relationship: negatively_regulates GO:0006096 ! glycolysis [Term] id: GO:0045821 name: positive regulation of glycolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycolysis." [GOC:go_curators] subset: gosubset_prok synonym: "activation of glycolysis" NARROW [] synonym: "stimulation of glycolysis" NARROW [] synonym: "up regulation of glycolysis" EXACT [] synonym: "up-regulation of glycolysis" EXACT [] synonym: "upregulation of glycolysis" EXACT [] is_a: GO:0006110 ! regulation of glycolysis is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010907 ! positive regulation of glucose metabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process relationship: positively_regulates GO:0006096 ! glycolysis [Term] id: GO:0045822 name: negative regulation of heart contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "down regulation of heart contraction" EXACT [] synonym: "down-regulation of heart contraction" EXACT [] synonym: "downregulation of heart contraction" EXACT [] synonym: "inhibition of heart contraction" NARROW [] synonym: "negative regulation of cardiac contraction" RELATED [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0060047 ! heart contraction [Term] id: GO:0045823 name: positive regulation of heart contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "activation of heart contraction" NARROW [] synonym: "positive regulation of cardiac contraction" EXACT [] synonym: "stimulation of heart contraction" NARROW [] synonym: "up regulation of heart contraction" EXACT [] synonym: "up-regulation of heart contraction" EXACT [] synonym: "upregulation of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0060047 ! heart contraction [Term] id: GO:0045824 name: negative regulation of innate immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] synonym: "down regulation of innate immune response" EXACT [] synonym: "down-regulation of innate immune response" EXACT [] synonym: "downregulation of innate immune response" EXACT [] synonym: "inhibition of innate immune response" NARROW [] is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0045087 ! innate immune response [Term] id: GO:0045825 name: negative regulation of intermediate filament polymerization and/or depolymerization namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators] comment: This term was made obsolete because it has been split. is_obsolete: true consider: GO:0030840 consider: GO:0030843 [Term] id: GO:0045826 name: positive regulation of intermediate filament polymerization and/or depolymerization namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators] comment: This term was made obsolete because it has been split. is_obsolete: true consider: GO:0030841 consider: GO:0030844 [Term] id: GO:0045827 name: negative regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of isoprenoid metabolic process" EXACT [] synonym: "down-regulation of isoprenoid metabolic process" EXACT [] synonym: "downregulation of isoprenoid metabolic process" EXACT [] synonym: "inhibition of isoprenoid metabolic process" NARROW [] synonym: "negative regulation of isoprenoid metabolism" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process relationship: negatively_regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0045828 name: positive regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] subset: gosubset_prok synonym: "activation of isoprenoid metabolic process" NARROW [] synonym: "positive regulation of isoprenoid metabolism" EXACT [] synonym: "stimulation of isoprenoid metabolic process" NARROW [] synonym: "up regulation of isoprenoid metabolic process" EXACT [] synonym: "up-regulation of isoprenoid metabolic process" EXACT [] synonym: "upregulation of isoprenoid metabolic process" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process relationship: positively_regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0045829 name: negative regulation of isotype switching namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching." [GOC:go_curators] synonym: "down regulation of isotype switching" EXACT [] synonym: "down-regulation of isotype switching" EXACT [] synonym: "downregulation of isotype switching" EXACT [] synonym: "inhibition of isotype switching" NARROW [] synonym: "negative regulation of class switch recombination" EXACT [] synonym: "negative regulation of class switching" EXACT [] synonym: "negative regulation of isotype switch recombination" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0045191 ! regulation of isotype switching is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:0050869 ! negative regulation of B cell activation relationship: negatively_regulates GO:0045190 ! isotype switching [Term] id: GO:0045830 name: positive regulation of isotype switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching." [GOC:go_curators] synonym: "activation of isotype switching" NARROW [] synonym: "positive regulation of class switch recombination" EXACT [] synonym: "positive regulation of class switching" EXACT [] synonym: "positive regulation of isotype switch recombination" EXACT [] synonym: "stimulation of isotype switching" NARROW [] synonym: "up regulation of isotype switching" EXACT [] synonym: "up-regulation of isotype switching" EXACT [] synonym: "upregulation of isotype switching" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0045191 ! regulation of isotype switching is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0050871 ! positive regulation of B cell activation relationship: positively_regulates GO:0045190 ! isotype switching [Term] id: GO:0045831 name: negative regulation of light-activated channel activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] synonym: "down regulation of light-activated channel activity" EXACT [] synonym: "down-regulation of light-activated channel activity" EXACT [] synonym: "downregulation of light-activated channel activity" EXACT [] synonym: "inhibition of light-activated channel activity" NARROW [] is_a: GO:0016061 ! regulation of light-activated channel activity is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity [Term] id: GO:0045832 name: positive regulation of light-activated channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] synonym: "activation of light-activated channel activity" NARROW [] synonym: "stimulation of light-activated channel activity" NARROW [] synonym: "up regulation of light-activated channel activity" EXACT [] synonym: "up-regulation of light-activated channel activity" EXACT [] synonym: "upregulation of light-activated channel activity" EXACT [] is_a: GO:0016061 ! regulation of light-activated channel activity is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity [Term] id: GO:0045833 name: negative regulation of lipid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of lipid metabolic process" EXACT [] synonym: "down-regulation of lipid metabolic process" EXACT [] synonym: "downregulation of lipid metabolic process" EXACT [] synonym: "inhibition of lipid metabolic process" NARROW [] synonym: "negative regulation of lipid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process relationship: negatively_regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0045834 name: positive regulation of lipid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] subset: gosubset_prok synonym: "activation of lipid metabolic process" NARROW [] synonym: "positive regulation of lipid metabolism" EXACT [] synonym: "stimulation of lipid metabolic process" NARROW [] synonym: "up regulation of lipid metabolic process" EXACT [] synonym: "up-regulation of lipid metabolic process" EXACT [] synonym: "upregulation of lipid metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process relationship: positively_regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0045835 name: negative regulation of meiosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "down regulation of meiosis" EXACT [] synonym: "down-regulation of meiosis" EXACT [] synonym: "downregulation of meiosis" EXACT [] synonym: "inhibition of meiosis" NARROW [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0040020 ! regulation of meiosis relationship: negatively_regulates GO:0007126 ! meiosis [Term] id: GO:0045836 name: positive regulation of meiosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "activation of meiosis" NARROW [] synonym: "stimulation of meiosis" NARROW [] synonym: "up regulation of meiosis" EXACT [] synonym: "up-regulation of meiosis" EXACT [] synonym: "upregulation of meiosis" EXACT [] is_a: GO:0040020 ! regulation of meiosis is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0007126 ! meiosis [Term] id: GO:0045837 name: negative regulation of membrane potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators] synonym: "down regulation of membrane potential" EXACT [] synonym: "down-regulation of membrane potential" EXACT [] synonym: "downregulation of membrane potential" EXACT [] synonym: "inhibition of membrane potential" NARROW [] synonym: "reduction of membrane potential" EXACT [GOC:rph] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0045838 name: positive regulation of membrane potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators] synonym: "activation of membrane potential" NARROW [] synonym: "elevation of membrane potential" EXACT [GOC:rph] synonym: "stimulation of membrane potential" NARROW [] synonym: "up regulation of membrane potential" EXACT [] synonym: "up-regulation of membrane potential" EXACT [] synonym: "upregulation of membrane potential" EXACT [] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0045839 name: negative regulation of mitosis namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of mitosis" EXACT [] synonym: "down-regulation of mitosis" EXACT [] synonym: "downregulation of mitosis" EXACT [] synonym: "inhibition of mitosis" NARROW [] is_a: GO:0007088 ! regulation of mitosis is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051784 ! negative regulation of nuclear division relationship: negatively_regulates GO:0007067 ! mitosis [Term] id: GO:0045840 name: positive regulation of mitosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "activation of mitosis" NARROW [] synonym: "mitogenic activity" NARROW [] synonym: "stimulation of mitosis" NARROW [] synonym: "up regulation of mitosis" EXACT [] synonym: "up-regulation of mitosis" EXACT [] synonym: "upregulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitosis is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0007067 ! mitosis [Term] id: GO:0045841 name: negative regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW [] is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition is_a: GO:0045839 ! negative regulation of mitosis relationship: negatively_regulates GO:0007091 ! mitotic metaphase/anaphase transition [Term] id: GO:0045842 name: positive regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] synonym: "activation of mitotic metaphase/anaphase transition" NARROW [] synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW [] synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT [] is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition is_a: GO:0045840 ! positive regulation of mitosis relationship: positively_regulates GO:0007091 ! mitotic metaphase/anaphase transition [Term] id: GO:0045843 name: negative regulation of striated muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "down regulation of striated muscle development" EXACT [] synonym: "down-regulation of striated muscle development" EXACT [] synonym: "downregulation of striated muscle development" EXACT [] synonym: "inhibition of striated muscle development" NARROW [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048635 ! negative regulation of muscle organ development relationship: negatively_regulates GO:0014706 ! striated muscle tissue development [Term] id: GO:0045844 name: positive regulation of striated muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "activation of striated muscle development" NARROW [] synonym: "stimulation of striated muscle development" NARROW [] synonym: "up regulation of striated muscle development" EXACT [] synonym: "up-regulation of striated muscle development" EXACT [] synonym: "upregulation of striated muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048636 ! positive regulation of muscle organ development relationship: positively_regulates GO:0014706 ! striated muscle tissue development [Term] id: GO:0045847 name: negative regulation of nitrogen utilization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] synonym: "down regulation of nitrogen utilization" EXACT [] synonym: "down-regulation of nitrogen utilization" EXACT [] synonym: "downregulation of nitrogen utilization" EXACT [] synonym: "inhibition of nitrogen utilization" NARROW [] is_a: GO:0006808 ! regulation of nitrogen utilization is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0019740 ! nitrogen utilization [Term] id: GO:0045848 name: positive regulation of nitrogen utilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] synonym: "activation of nitrogen utilization" NARROW [] synonym: "stimulation of nitrogen utilization" NARROW [] synonym: "up regulation of nitrogen utilization" EXACT [] synonym: "up-regulation of nitrogen utilization" EXACT [] synonym: "upregulation of nitrogen utilization" EXACT [] is_a: GO:0006808 ! regulation of nitrogen utilization is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0019740 ! nitrogen utilization [Term] id: GO:0045849 name: negative regulation of nurse cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptosis." [GOC:go_curators] synonym: "down regulation of nurse cell apoptosis" EXACT [] synonym: "down-regulation of nurse cell apoptosis" EXACT [] synonym: "downregulation of nurse cell apoptosis" EXACT [] synonym: "inhibition of nurse cell apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptosis is_a: GO:0045477 ! regulation of nurse cell apoptosis is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0045476 ! nurse cell apoptosis [Term] id: GO:0045850 name: positive regulation of nurse cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nurse cell apoptosis." [GOC:go_curators] synonym: "activation of nurse cell apoptosis" NARROW [] synonym: "stimulation of nurse cell apoptosis" NARROW [] synonym: "up regulation of nurse cell apoptosis" EXACT [] synonym: "up-regulation of nurse cell apoptosis" EXACT [] synonym: "upregulation of nurse cell apoptosis" EXACT [] is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:0045477 ! regulation of nurse cell apoptosis is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0045476 ! nurse cell apoptosis [Term] id: GO:0045851 name: pH reduction namespace: biological_process def: "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] synonym: "acidification" EXACT [] is_a: GO:0006885 ! regulation of pH [Term] id: GO:0045852 name: pH elevation namespace: biological_process def: "Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] is_a: GO:0006885 ! regulation of pH [Term] id: GO:0045853 name: negative regulation of bicoid mRNA localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators] synonym: "down regulation of bicoid mRNA localization" EXACT [] synonym: "down-regulation of bicoid mRNA localization" EXACT [] synonym: "downregulation of bicoid mRNA localization" EXACT [] synonym: "inhibition of bicoid mRNA localization" NARROW [] synonym: "negative regulation of bicoid mRNA localisation" EXACT [GOC:mah] is_a: GO:0008359 ! regulation of bicoid mRNA localization is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0045450 ! bicoid mRNA localization [Term] id: GO:0045854 name: positive regulation of bicoid mRNA localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators] synonym: "activation of bicoid mRNA localization" NARROW [] synonym: "positive regulation of bicoid mRNA localisation" EXACT [GOC:mah] synonym: "stimulation of bicoid mRNA localization" NARROW [] synonym: "up regulation of bicoid mRNA localization" EXACT [] synonym: "up-regulation of bicoid mRNA localization" EXACT [] synonym: "upregulation of bicoid mRNA localization" EXACT [] is_a: GO:0008359 ! regulation of bicoid mRNA localization is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0045450 ! bicoid mRNA localization [Term] id: GO:0045855 name: negative regulation of pole plasm oskar mRNA localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] synonym: "down regulation of pole plasm oskar mRNA localization" EXACT [] synonym: "down-regulation of pole plasm oskar mRNA localization" EXACT [] synonym: "downregulation of pole plasm oskar mRNA localization" EXACT [] synonym: "inhibition of pole plasm oskar mRNA localization" NARROW [] synonym: "negative regulation of oocyte pole plasm oskar mRNA localization" EXACT [] synonym: "negative regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0045451 ! pole plasm oskar mRNA localization [Term] id: GO:0045856 name: positive regulation of pole plasm oskar mRNA localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] synonym: "activation of pole plasm oskar mRNA localization" NARROW [] synonym: "positive regulation of oocyte pole plasm oskar mRNA localization" EXACT [] synonym: "positive regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] synonym: "stimulation of pole plasm oskar mRNA localization" NARROW [] synonym: "up regulation of pole plasm oskar mRNA localization" EXACT [] synonym: "up-regulation of pole plasm oskar mRNA localization" EXACT [] synonym: "upregulation of pole plasm oskar mRNA localization" EXACT [] is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0045451 ! pole plasm oskar mRNA localization [Term] id: GO:0045857 name: negative regulation of molecular function, epigenetic namespace: biological_process def: "Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of protein activity, epigenetic" EXACT [] synonym: "down-regulation of protein activity, epigenetic" EXACT [] synonym: "downregulation of protein activity, epigenetic" EXACT [] synonym: "inhibition of protein activity, epigenetic" NARROW [] synonym: "negative regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] is_a: GO:0040030 ! regulation of molecular function, epigenetic is_a: GO:0044092 ! negative regulation of molecular function [Term] id: GO:0045858 name: positive regulation of molecular function, epigenetic namespace: biological_process def: "Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of protein activity, epigenetic" NARROW [] synonym: "positive regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of protein activity, epigenetic" NARROW [] synonym: "up regulation of protein activity, epigenetic" EXACT [] synonym: "up-regulation of protein activity, epigenetic" EXACT [] synonym: "upregulation of protein activity, epigenetic" EXACT [] is_a: GO:0040030 ! regulation of molecular function, epigenetic is_a: GO:0044093 ! positive regulation of molecular function [Term] id: GO:0045859 name: regulation of protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] subset: gosubset_prok is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0043549 ! regulation of kinase activity [Term] id: GO:0045860 name: positive regulation of protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] subset: gosubset_prok synonym: "stimulation of protein kinase activity" NARROW [] synonym: "up regulation of protein kinase activity" EXACT [] synonym: "up-regulation of protein kinase activity" EXACT [] synonym: "upregulation of protein kinase activity" EXACT [] is_a: GO:0033674 ! positive regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity [Term] id: GO:0045861 name: negative regulation of proteolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of proteolysis" EXACT [] synonym: "down-regulation of proteolysis" EXACT [] synonym: "downregulation of proteolysis" EXACT [] synonym: "inhibition of proteolysis" NARROW [] synonym: "negative regulation of peptidolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032269 ! negative regulation of cellular protein metabolic process relationship: negatively_regulates GO:0006508 ! proteolysis [Term] id: GO:0045862 name: positive regulation of proteolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] subset: gosubset_prok synonym: "activation of proteolysis" NARROW [] synonym: "positive regulation of peptidolysis" EXACT [] synonym: "stimulation of proteolysis" NARROW [] synonym: "up regulation of proteolysis" EXACT [] synonym: "up-regulation of proteolysis" EXACT [] synonym: "upregulation of proteolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032270 ! positive regulation of cellular protein metabolic process relationship: positively_regulates GO:0006508 ! proteolysis [Term] id: GO:0045863 name: negative regulation of pteridine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of pteridine metabolic process" EXACT [] synonym: "down-regulation of pteridine metabolic process" EXACT [] synonym: "downregulation of pteridine metabolic process" EXACT [] synonym: "inhibition of pteridine metabolic process" NARROW [] synonym: "negative regulation of pteridine metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0042068 ! regulation of pteridine metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process relationship: negatively_regulates GO:0019889 ! pteridine metabolic process [Term] id: GO:0045864 name: positive regulation of pteridine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] subset: gosubset_prok synonym: "activation of pteridine metabolic process" NARROW [] synonym: "positive regulation of pteridine metabolism" EXACT [] synonym: "stimulation of pteridine metabolic process" NARROW [] synonym: "up regulation of pteridine metabolic process" EXACT [] synonym: "up-regulation of pteridine metabolic process" EXACT [] synonym: "upregulation of pteridine metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0042068 ! regulation of pteridine metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process relationship: positively_regulates GO:0019889 ! pteridine metabolic process [Term] id: GO:0045865 name: regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it describes a substrate-specific process. is_obsolete: true replaced_by: GO:0000019 [Term] id: GO:0045866 name: positive regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it describes a substrate-specific process. is_obsolete: true consider: GO:0045951 [Term] id: GO:0045869 name: negative regulation of retroviral genome replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of retroviral genome replication." [GOC:go_curators] synonym: "down regulation of retroviral genome replication" EXACT [] synonym: "down-regulation of retroviral genome replication" EXACT [] synonym: "downregulation of retroviral genome replication" EXACT [] synonym: "inhibition of retroviral genome replication" NARROW [] is_a: GO:0045071 ! negative regulation of viral genome replication is_a: GO:0045091 ! regulation of retroviral genome replication relationship: negatively_regulates GO:0045090 ! retroviral genome replication [Term] id: GO:0045870 name: positive regulation of retroviral genome replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retroviral genome replication." [GOC:go_curators] synonym: "activation of retroviral genome replication" NARROW [] synonym: "stimulation of retroviral genome replication" NARROW [] synonym: "up regulation of retroviral genome replication" EXACT [] synonym: "up-regulation of retroviral genome replication" EXACT [] synonym: "upregulation of retroviral genome replication" EXACT [] is_a: GO:0045070 ! positive regulation of viral genome replication is_a: GO:0045091 ! regulation of retroviral genome replication relationship: positively_regulates GO:0045090 ! retroviral genome replication [Term] id: GO:0045871 name: negative regulation of rhodopsin gene expression namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of rhodopsin gene activity" EXACT [] synonym: "down-regulation of rhodopsin gene activity" EXACT [] synonym: "downregulation of rhodopsin gene activity" EXACT [] synonym: "inhibition of rhodopsin gene activity" NARROW [] synonym: "negative regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0007468 ! regulation of rhodopsin gene expression is_a: GO:0010629 ! negative regulation of gene expression [Term] id: GO:0045872 name: positive regulation of rhodopsin gene expression namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of rhodopsin gene activity" NARROW [] synonym: "positive regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of rhodopsin gene activity" NARROW [] synonym: "up regulation of rhodopsin gene activity" EXACT [] synonym: "up-regulation of rhodopsin gene activity" EXACT [] synonym: "upregulation of rhodopsin gene activity" EXACT [] is_a: GO:0007468 ! regulation of rhodopsin gene expression is_a: GO:0010628 ! positive regulation of gene expression [Term] id: GO:0045873 name: negative regulation of sevenless signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] synonym: "down regulation of sevenless signaling pathway" EXACT [] synonym: "down-regulation of sevenless signaling pathway" EXACT [] synonym: "downregulation of sevenless signaling pathway" EXACT [] synonym: "inhibition of sevenless signaling pathway" NARROW [] synonym: "negative regulation of sev signaling pathway" EXACT [] synonym: "negative regulation of sevenless signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0045501 ! regulation of sevenless signaling pathway relationship: negatively_regulates GO:0045500 ! sevenless signaling pathway [Term] id: GO:0045874 name: positive regulation of sevenless signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] synonym: "activation of sevenless signaling pathway" NARROW [] synonym: "positive regulation of sev signaling pathway" EXACT [] synonym: "positive regulation of sevenless signalling pathway" EXACT [] synonym: "stimulation of sevenless signaling pathway" NARROW [] synonym: "up regulation of sevenless signaling pathway" EXACT [] synonym: "up-regulation of sevenless signaling pathway" EXACT [] synonym: "upregulation of sevenless signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0045501 ! regulation of sevenless signaling pathway relationship: positively_regulates GO:0045500 ! sevenless signaling pathway [Term] id: GO:0045875 name: negative regulation of sister chromatid cohesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] synonym: "down regulation of sister chromatid cohesion" EXACT [] synonym: "down-regulation of sister chromatid cohesion" EXACT [] synonym: "downregulation of sister chromatid cohesion" EXACT [] synonym: "inhibition of sister chromatid cohesion" NARROW [] is_a: GO:0007063 ! regulation of sister chromatid cohesion is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010948 ! negative regulation of cell cycle process relationship: negatively_regulates GO:0007062 ! sister chromatid cohesion [Term] id: GO:0045876 name: positive regulation of sister chromatid cohesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] synonym: "activation of sister chromatid cohesion" NARROW [] synonym: "stimulation of sister chromatid cohesion" NARROW [] synonym: "up regulation of sister chromatid cohesion" EXACT [] synonym: "up-regulation of sister chromatid cohesion" EXACT [] synonym: "upregulation of sister chromatid cohesion" EXACT [] is_a: GO:0007063 ! regulation of sister chromatid cohesion is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0007062 ! sister chromatid cohesion [Term] id: GO:0045879 name: negative regulation of smoothened signaling pathway namespace: biological_process alt_id: GO:0045877 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] synonym: "down regulation of smoothened signaling pathway" EXACT [] synonym: "down-regulation of smoothened signaling pathway" EXACT [] synonym: "downregulation of smoothened signaling pathway" EXACT [] synonym: "inhibition of smoothened signaling pathway" NARROW [] synonym: "negative regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of smoothened activity" RELATED [] synonym: "negative regulation of smoothened by patched" NARROW [] synonym: "negative regulation of smoothened receptor activity by patched" RELATED [] synonym: "negative regulation of smoothened signalling pathway" EXACT [] is_a: GO:0008589 ! regulation of smoothened signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0007224 ! smoothened signaling pathway [Term] id: GO:0045880 name: positive regulation of smoothened signaling pathway namespace: biological_process alt_id: GO:0045878 def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators] synonym: "activation of smoothened signaling pathway" NARROW [] synonym: "positive regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "positive regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "positive regulation of smoothened by patched" RELATED [] synonym: "positive regulation of smoothened receptor activity by patched" RELATED [] synonym: "positive regulation of smoothened signalling pathway" EXACT [] synonym: "stimulation of smoothened signaling pathway" NARROW [] synonym: "up regulation of smoothened signaling pathway" EXACT [] synonym: "up-regulation of smoothened signaling pathway" EXACT [] synonym: "upregulation of smoothened signaling pathway" EXACT [] is_a: GO:0008589 ! regulation of smoothened signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0007224 ! smoothened signaling pathway [Term] id: GO:0045881 name: positive regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sporulation." [GOC:go_curators] synonym: "activation of sporulation" NARROW [] synonym: "stimulation of sporulation" NARROW [] synonym: "up regulation of sporulation" EXACT [] synonym: "up-regulation of sporulation" EXACT [] synonym: "upregulation of sporulation" EXACT [] is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043938 ! positive regulation of sporulation is_a: GO:0045597 ! positive regulation of cell differentiation relationship: positively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore [Term] id: GO:0045882 name: negative regulation of sulfur utilization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of sulfur utilization" EXACT [] synonym: "down-regulation of sulfur utilization" EXACT [] synonym: "downregulation of sulfur utilization" EXACT [] synonym: "inhibition of sulfur utilization" NARROW [] synonym: "negative regulation of sulphur utilization" EXACT [] is_a: GO:0006792 ! regulation of sulfur utilization is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0006791 ! sulfur utilization [Term] id: GO:0045883 name: positive regulation of sulfur utilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sulfur utilization." [GOC:go_curators] subset: gosubset_prok synonym: "activation of sulfur utilization" NARROW [] synonym: "positive regulation of sulphur utilization" EXACT [] synonym: "stimulation of sulfur utilization" NARROW [] synonym: "up regulation of sulfur utilization" EXACT [] synonym: "up-regulation of sulfur utilization" EXACT [] synonym: "upregulation of sulfur utilization" EXACT [] is_a: GO:0006792 ! regulation of sulfur utilization is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0006791 ! sulfur utilization [Term] id: GO:0045884 name: regulation of survival gene product expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] synonym: "regulation of survival gene products" BROAD [] is_a: GO:0006916 ! anti-apoptosis is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0045885 name: positive regulation of survival gene product expression namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of survival gene product activity" BROAD [] synonym: "positive regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] synonym: "positive regulation of survival gene products" BROAD [] synonym: "stimulation of survival gene product activity" NARROW [] synonym: "up regulation of survival gene product activity" BROAD [] synonym: "up-regulation of survival gene product activity" BROAD [] synonym: "upregulation of survival gene product activity" BROAD [] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0045884 ! regulation of survival gene product expression [Term] id: GO:0045886 name: negative regulation of synaptic growth at neuromuscular junction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] synonym: "down regulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "down-regulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "downregulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "inhibition of synaptic growth at neuromuscular junction" NARROW [] is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051964 ! negative regulation of synaptogenesis relationship: negatively_regulates GO:0051124 ! synaptic growth at neuromuscular junction [Term] id: GO:0045887 name: positive regulation of synaptic growth at neuromuscular junction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] synonym: "activation of synaptic growth at neuromuscular junction" NARROW [] synonym: "stimulation of synaptic growth at neuromuscular junction" NARROW [] synonym: "up regulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "up-regulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "upregulation of synaptic growth at neuromuscular junction" EXACT [] is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051965 ! positive regulation of synaptogenesis relationship: positively_regulates GO:0051124 ! synaptic growth at neuromuscular junction [Term] id: GO:0045888 name: regulation of transcription of homeotic gene (Polycomb group) namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0045889 name: positive regulation of transcription of homeotic gene (Polycomb group) namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0045890 name: regulation of transcription of homeotic gene (trithorax group) namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0045891 name: negative regulation of transcription of homeotic gene (trithorax group) namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0045892 name: negative regulation of transcription, DNA-dependent namespace: biological_process alt_id: GO:0016481 alt_id: GO:0032582 alt_id: GO:0061021 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH] subset: gosubset_prok synonym: "down regulation of gene-specific transcription" RELATED [] synonym: "down regulation of transcription, DNA-dependent" EXACT [] synonym: "down-regulation of gene-specific transcription" RELATED [] synonym: "down-regulation of transcription, DNA-dependent" EXACT [] synonym: "downregulation of gene-specific transcription" RELATED [] synonym: "downregulation of transcription, DNA-dependent" EXACT [] synonym: "inhibition of gene-specific transcription" RELATED [] synonym: "inhibition of transcription, DNA-dependent" NARROW [] synonym: "negative regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "negative regulation of gene-specific transcription" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0045893 name: positive regulation of transcription, DNA-dependent namespace: biological_process alt_id: GO:0043193 alt_id: GO:0045941 alt_id: GO:0061020 def: "Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH] subset: gosubset_prok synonym: "activation of gene-specific transcription" RELATED [] synonym: "activation of transcription, DNA-dependent" NARROW [] synonym: "positive regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "positive regulation of gene-specific transcription" RELATED [] synonym: "stimulation of gene-specific transcription" NARROW [] synonym: "stimulation of transcription, DNA-dependent" NARROW [] synonym: "up regulation of gene-specific transcription" RELATED [] synonym: "up regulation of transcription, DNA-dependent" EXACT [] synonym: "up-regulation of gene-specific transcription" RELATED [] synonym: "up-regulation of transcription, DNA-dependent" EXACT [] synonym: "upregulation of gene-specific transcription" RELATED [] synonym: "upregulation of transcription, DNA-dependent" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0045894 name: negative regulation of transcription, mating-type specific namespace: biological_process def: "Any mating-type specific process that stops, prevents or reduces the rate of transcription." [GOC:go_curators] synonym: "down regulation of transcription, mating-type specific" EXACT [] synonym: "down-regulation of transcription, mating-type specific" EXACT [] synonym: "downregulation of transcription, mating-type specific" EXACT [] synonym: "inhibition of transcription, mating-type specific" NARROW [] is_a: GO:0007532 ! regulation of transcription, mating-type specific is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0045895 name: positive regulation of transcription, mating-type specific namespace: biological_process def: "Any mating-type specific process that activates or increases the rate of transcription." [GOC:go_curators] synonym: "activation of transcription, mating-type specific" NARROW [] synonym: "stimulation of transcription, mating-type specific" NARROW [] synonym: "up regulation of transcription, mating-type specific" EXACT [] synonym: "up-regulation of transcription, mating-type specific" EXACT [] synonym: "upregulation of transcription, mating-type specific" EXACT [] is_a: GO:0007532 ! regulation of transcription, mating-type specific is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent [Term] id: GO:0045896 name: regulation of transcription during mitosis namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] synonym: "mitotic regulation of transcription" EXACT [] synonym: "regulation of transcription, mitotic" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-dependent [Term] id: GO:0045897 name: positive regulation of transcription during mitosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] synonym: "activation of transcription during mitosis" NARROW [GOC:mah] synonym: "mitotic activation of transcription" EXACT [] synonym: "positive regulation of transcription, mitotic" EXACT [GOC:mah] synonym: "stimulation of transcription during mitosis" NARROW [GOC:mah] synonym: "up regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "up-regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "upregulation of transcription during mitosis" EXACT [GOC:mah] is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent is_a: GO:0045896 ! regulation of transcription during mitosis [Term] id: GO:0045898 name: regulation of RNA polymerase II transcriptional preinitiation complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] synonym: "regulation of RNA polymerase II transcriptional preinitiation complex formation" RELATED [] is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter relationship: regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly [Term] id: GO:0045899 name: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] synonym: "activation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] synonym: "positive regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT [] synonym: "stimulation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] synonym: "up regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "up-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "upregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] is_a: GO:0045898 ! regulation of RNA polymerase II transcriptional preinitiation complex assembly is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly [Term] id: GO:0045900 name: negative regulation of translational elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of translational elongation" EXACT [] synonym: "down-regulation of translational elongation" EXACT [] synonym: "downregulation of translational elongation" EXACT [] synonym: "inhibition of translational elongation" NARROW [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0017148 ! negative regulation of translation relationship: negatively_regulates GO:0006414 ! translational elongation [Term] id: GO:0045901 name: positive regulation of translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators] subset: gosubset_prok synonym: "activation of translational elongation" NARROW [] synonym: "stimulation of translational elongation" NARROW [] synonym: "up regulation of translational elongation" EXACT [] synonym: "up-regulation of translational elongation" EXACT [] synonym: "upregulation of translational elongation" EXACT [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0045727 ! positive regulation of translation relationship: positively_regulates GO:0006414 ! translational elongation [Term] id: GO:0045902 name: negative regulation of translational fidelity namespace: biological_process def: "Any process that decreases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] subset: gosubset_prok synonym: "down regulation of translational fidelity" EXACT [] synonym: "down-regulation of translational fidelity" EXACT [] synonym: "downregulation of translational fidelity" EXACT [] synonym: "inhibition of translational fidelity" NARROW [] is_a: GO:0006450 ! regulation of translational fidelity is_a: GO:0017148 ! negative regulation of translation [Term] id: GO:0045903 name: positive regulation of translational fidelity namespace: biological_process def: "Any process that increases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] subset: gosubset_prok synonym: "activation of translational fidelity" NARROW [] synonym: "stimulation of translational fidelity" NARROW [] synonym: "up regulation of translational fidelity" EXACT [] synonym: "up-regulation of translational fidelity" EXACT [] synonym: "upregulation of translational fidelity" EXACT [] is_a: GO:0006450 ! regulation of translational fidelity is_a: GO:0045727 ! positive regulation of translation [Term] id: GO:0045904 name: negative regulation of translational termination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of translational termination" EXACT [] synonym: "down-regulation of translational termination" EXACT [] synonym: "downregulation of translational termination" EXACT [] synonym: "inhibition of translational termination" NARROW [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043242 ! negative regulation of protein complex disassembly relationship: negatively_regulates GO:0006415 ! translational termination [Term] id: GO:0045905 name: positive regulation of translational termination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators] subset: gosubset_prok synonym: "activation of translational termination" NARROW [] synonym: "stimulation of translational termination" NARROW [] synonym: "up regulation of translational termination" EXACT [] synonym: "up-regulation of translational termination" EXACT [] synonym: "upregulation of translational termination" EXACT [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0043243 ! positive regulation of protein complex disassembly is_a: GO:0045727 ! positive regulation of translation relationship: positively_regulates GO:0006415 ! translational termination [Term] id: GO:0045906 name: negative regulation of vasoconstriction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction." [GOC:go_curators] synonym: "down regulation of vasoconstriction" EXACT [] synonym: "down-regulation of vasoconstriction" EXACT [] synonym: "downregulation of vasoconstriction" EXACT [] synonym: "inhibition of vasoconstriction" NARROW [] is_a: GO:0019229 ! regulation of vasoconstriction is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0042310 ! vasoconstriction [Term] id: GO:0045907 name: positive regulation of vasoconstriction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasoconstriction." [GOC:go_curators] synonym: "activation of vasoconstriction" NARROW [] synonym: "stimulation of vasoconstriction" NARROW [] synonym: "up regulation of vasoconstriction" EXACT [] synonym: "up-regulation of vasoconstriction" EXACT [] synonym: "upregulation of vasoconstriction" EXACT [] is_a: GO:0019229 ! regulation of vasoconstriction is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0042310 ! vasoconstriction [Term] id: GO:0045908 name: negative regulation of vasodilation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vasodilation." [GOC:go_curators] synonym: "down regulation of vasodilation" EXACT [] synonym: "down-regulation of vasodilation" EXACT [] synonym: "downregulation of vasodilation" EXACT [] synonym: "inhibition of vasodilation" NARROW [] is_a: GO:0042312 ! regulation of vasodilation is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0042311 ! vasodilation [Term] id: GO:0045909 name: positive regulation of vasodilation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasodilation." [GOC:go_curators] synonym: "activation of vasodilation" NARROW [] synonym: "stimulation of vasodilation" NARROW [] synonym: "up regulation of vasodilation" EXACT [] synonym: "up-regulation of vasodilation" EXACT [] synonym: "upregulation of vasodilation" EXACT [] is_a: GO:0042312 ! regulation of vasodilation is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0042311 ! vasodilation [Term] id: GO:0045910 name: negative regulation of DNA recombination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of DNA recombination" EXACT [] synonym: "down-regulation of DNA recombination" EXACT [] synonym: "downregulation of DNA recombination" EXACT [] synonym: "inhibition of DNA recombination" NARROW [] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0051053 ! negative regulation of DNA metabolic process relationship: negatively_regulates GO:0006310 ! DNA recombination [Term] id: GO:0045911 name: positive regulation of DNA recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators] subset: gosubset_prok synonym: "activation of DNA recombination" NARROW [] synonym: "stimulation of DNA recombination" NARROW [] synonym: "up regulation of DNA recombination" EXACT [] synonym: "up-regulation of DNA recombination" EXACT [] synonym: "upregulation of DNA recombination" EXACT [] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0051054 ! positive regulation of DNA metabolic process relationship: positively_regulates GO:0006310 ! DNA recombination [Term] id: GO:0045912 name: negative regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of carbohydrate metabolic process" EXACT [] synonym: "down-regulation of carbohydrate metabolic process" EXACT [] synonym: "downregulation of carbohydrate metabolic process" EXACT [] synonym: "inhibition of carbohydrate metabolic process" NARROW [] synonym: "negative regulation of carbohydrate metabolism" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009892 ! negative regulation of metabolic process relationship: negatively_regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0045913 name: positive regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] subset: gosubset_prok synonym: "activation of carbohydrate metabolic process" NARROW [] synonym: "positive regulation of carbohydrate metabolism" EXACT [] synonym: "stimulation of carbohydrate metabolic process" NARROW [] synonym: "up regulation of carbohydrate metabolic process" EXACT [] synonym: "up-regulation of carbohydrate metabolic process" EXACT [] synonym: "upregulation of carbohydrate metabolic process" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009893 ! positive regulation of metabolic process relationship: positively_regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0045914 name: negative regulation of catecholamine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of catecholamine metabolic process" EXACT [] synonym: "down-regulation of catecholamine metabolic process" EXACT [] synonym: "downregulation of catecholamine metabolic process" EXACT [] synonym: "inhibition of catecholamine metabolic process" NARROW [] synonym: "negative regulation of catecholamine metabolism" EXACT [] is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0042069 ! regulation of catecholamine metabolic process relationship: negatively_regulates GO:0006584 ! catecholamine metabolic process [Term] id: GO:0045915 name: positive regulation of catecholamine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] subset: gosubset_prok synonym: "activation of catecholamine metabolic process" NARROW [] synonym: "positive regulation of catecholamine metabolism" EXACT [] synonym: "stimulation of catecholamine metabolic process" NARROW [] synonym: "up regulation of catecholamine metabolic process" EXACT [] synonym: "up-regulation of catecholamine metabolic process" EXACT [] synonym: "upregulation of catecholamine metabolic process" EXACT [] is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0042069 ! regulation of catecholamine metabolic process relationship: positively_regulates GO:0006584 ! catecholamine metabolic process [Term] id: GO:0045916 name: negative regulation of complement activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation." [GOC:go_curators] synonym: "down regulation of complement activation" EXACT [] synonym: "down-regulation of complement activation" EXACT [] synonym: "downregulation of complement activation" EXACT [] synonym: "inhibition of complement activation" NARROW [] synonym: "negative regulation of complement cascade" EXACT [GOC:add] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0010955 ! negative regulation of protein maturation by peptide bond cleavage is_a: GO:0030449 ! regulation of complement activation is_a: GO:2000258 ! negative regulation of protein activation cascade relationship: negatively_regulates GO:0006956 ! complement activation [Term] id: GO:0045917 name: positive regulation of complement activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation." [GOC:go_curators] synonym: "activation of complement activation" NARROW [] synonym: "positive regulation of complement cascade" EXACT [GOC:add] synonym: "stimulation of complement activation" NARROW [] synonym: "up regulation of complement activation" EXACT [] synonym: "up-regulation of complement activation" EXACT [] synonym: "upregulation of complement activation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0010954 ! positive regulation of protein maturation by peptide bond cleavage is_a: GO:0030449 ! regulation of complement activation is_a: GO:2000259 ! positive regulation of protein activation cascade relationship: positively_regulates GO:0006956 ! complement activation [Term] id: GO:0045918 name: negative regulation of cytolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of cytolysis" EXACT [] synonym: "down-regulation of cytolysis" EXACT [] synonym: "downregulation of cytolysis" EXACT [] synonym: "inhibition of cytolysis" NARROW [] is_a: GO:0042268 ! regulation of cytolysis is_a: GO:0060548 ! negative regulation of cell death relationship: negatively_regulates GO:0019835 ! cytolysis [Term] id: GO:0045919 name: positive regulation of cytolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytolysis." [GOC:go_curators] subset: gosubset_prok synonym: "activation of cytolysis" NARROW [] synonym: "stimulation of cytolysis" NARROW [] synonym: "up regulation of cytolysis" EXACT [] synonym: "up-regulation of cytolysis" EXACT [] synonym: "upregulation of cytolysis" EXACT [] is_a: GO:0010942 ! positive regulation of cell death is_a: GO:0042268 ! regulation of cytolysis relationship: positively_regulates GO:0019835 ! cytolysis [Term] id: GO:0045920 name: negative regulation of exocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "down regulation of exocytosis" EXACT [] synonym: "down-regulation of exocytosis" EXACT [] synonym: "downregulation of exocytosis" EXACT [] synonym: "inhibition of exocytosis" NARROW [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion relationship: negatively_regulates GO:0006887 ! exocytosis [Term] id: GO:0045921 name: positive regulation of exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators] subset: gosubset_prok synonym: "activation of exocytosis" NARROW [] synonym: "stimulation of exocytosis" NARROW [] synonym: "up regulation of exocytosis" EXACT [] synonym: "up-regulation of exocytosis" EXACT [] synonym: "upregulation of exocytosis" EXACT [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion relationship: positively_regulates GO:0006887 ! exocytosis [Term] id: GO:0045922 name: negative regulation of fatty acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of fatty acid metabolic process" EXACT [] synonym: "down-regulation of fatty acid metabolic process" EXACT [] synonym: "downregulation of fatty acid metabolic process" EXACT [] synonym: "inhibition of fatty acid metabolic process" NARROW [] synonym: "negative regulation of fatty acid metabolism" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process relationship: negatively_regulates GO:0006631 ! fatty acid metabolic process [Term] id: GO:0045923 name: positive regulation of fatty acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] subset: gosubset_prok synonym: "activation of fatty acid metabolic process" NARROW [] synonym: "positive regulation of fatty acid metabolism" EXACT [] synonym: "stimulation of fatty acid metabolic process" NARROW [] synonym: "up regulation of fatty acid metabolic process" EXACT [] synonym: "up-regulation of fatty acid metabolic process" EXACT [] synonym: "upregulation of fatty acid metabolic process" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process relationship: positively_regulates GO:0006631 ! fatty acid metabolic process [Term] id: GO:0045924 name: regulation of female receptivity namespace: biological_process alt_id: GO:0060181 def: "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "female receptivity" RELATED [GOC:dph, GOC:tb] is_a: GO:0060180 ! female mating behavior is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0045925 name: positive regulation of female receptivity namespace: biological_process def: "Any process that activates or increases the receptiveness of a female to male advances." [GOC:go_curators] synonym: "activation of female receptivity" NARROW [] synonym: "stimulation of female receptivity" NARROW [] synonym: "up regulation of female receptivity" EXACT [] synonym: "up-regulation of female receptivity" EXACT [] synonym: "upregulation of female receptivity" EXACT [] is_a: GO:0045924 ! regulation of female receptivity [Term] id: GO:0045926 name: negative regulation of growth namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of growth" EXACT [] synonym: "down-regulation of growth" EXACT [] synonym: "downregulation of growth" EXACT [] synonym: "inhibition of growth" NARROW [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0040007 ! growth [Term] id: GO:0045927 name: positive regulation of growth namespace: biological_process def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] subset: gosubset_prok synonym: "activation of growth" NARROW [] synonym: "stimulation of growth" NARROW [] synonym: "up regulation of growth" EXACT [] synonym: "up-regulation of growth" EXACT [] synonym: "upregulation of growth" EXACT [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0040007 ! growth [Term] id: GO:0045928 name: negative regulation of juvenile hormone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone metabolic process" EXACT [] synonym: "down-regulation of juvenile hormone metabolic process" EXACT [] synonym: "downregulation of juvenile hormone metabolic process" EXACT [] synonym: "inhibition of juvenile hormone metabolic process" NARROW [] synonym: "negative regulation of juvenile hormone metabolism" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process relationship: negatively_regulates GO:0006716 ! juvenile hormone metabolic process [Term] id: GO:0045929 name: positive regulation of juvenile hormone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone metabolic process" NARROW [] synonym: "positive regulation of juvenile hormone metabolism" EXACT [] synonym: "stimulation of juvenile hormone metabolic process" NARROW [] synonym: "up regulation of juvenile hormone metabolic process" EXACT [] synonym: "up-regulation of juvenile hormone metabolic process" EXACT [] synonym: "upregulation of juvenile hormone metabolic process" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process relationship: positively_regulates GO:0006716 ! juvenile hormone metabolic process [Term] id: GO:0045930 name: negative regulation of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] synonym: "downregulation of progression through mitotic cell cycle" EXACT [] synonym: "inhibition of progression through mitotic cell cycle" NARROW [] synonym: "negative regulation of mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045786 ! negative regulation of cell cycle relationship: negatively_regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0045931 name: positive regulation of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through mitotic cell cycle" NARROW [] synonym: "positive regulation of mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through mitotic cell cycle" NARROW [] synonym: "up regulation of progression through mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] synonym: "upregulation of progression through mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045787 ! positive regulation of cell cycle relationship: positively_regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0045932 name: negative regulation of muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "down regulation of muscle contraction" EXACT [] synonym: "down-regulation of muscle contraction" EXACT [] synonym: "downregulation of muscle contraction" EXACT [] synonym: "inhibition of muscle contraction" NARROW [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0006936 ! muscle contraction [Term] id: GO:0045933 name: positive regulation of muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "activation of muscle contraction" NARROW [] synonym: "stimulation of muscle contraction" NARROW [] synonym: "up regulation of muscle contraction" EXACT [] synonym: "up-regulation of muscle contraction" EXACT [] synonym: "upregulation of muscle contraction" EXACT [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0006936 ! muscle contraction [Term] id: GO:0045934 name: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process namespace: biological_process def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process relationship: negatively_regulates GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Term] id: GO:0045935 name: positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process namespace: biological_process def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process relationship: positively_regulates GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Term] id: GO:0045936 name: negative regulation of phosphate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of phosphate metabolic process" EXACT [] synonym: "down-regulation of phosphate metabolic process" EXACT [] synonym: "downregulation of phosphate metabolic process" EXACT [] synonym: "inhibition of phosphate metabolic process" NARROW [] synonym: "negative regulation of phosphate metabolism" EXACT [] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process relationship: negatively_regulates GO:0006796 ! phosphate metabolic process [Term] id: GO:0045937 name: positive regulation of phosphate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] subset: gosubset_prok synonym: "activation of phosphate metabolic process" NARROW [] synonym: "positive regulation of phosphate metabolism" EXACT [] synonym: "stimulation of phosphate metabolic process" NARROW [] synonym: "up regulation of phosphate metabolic process" EXACT [] synonym: "up-regulation of phosphate metabolic process" EXACT [] synonym: "upregulation of phosphate metabolic process" EXACT [] is_a: GO:0010562 ! positive regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process relationship: positively_regulates GO:0006796 ! phosphate metabolic process [Term] id: GO:0045938 name: positive regulation of circadian sleep/wake cycle, sleep namespace: biological_process def: "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] synonym: "activation of circadian sleep/wake cycle, sleep" NARROW [] synonym: "positive regulation of sleep" EXACT [] synonym: "stimulation of circadian sleep/wake cycle, sleep" NARROW [] synonym: "up regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "up-regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "upregulation of circadian sleep/wake cycle, sleep" EXACT [] is_a: GO:0042753 ! positive regulation of circadian rhythm is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0045939 name: negative regulation of steroid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of steroid metabolic process" EXACT [] synonym: "down-regulation of steroid metabolic process" EXACT [] synonym: "downregulation of steroid metabolic process" EXACT [] synonym: "inhibition of steroid metabolic process" NARROW [] synonym: "negative regulation of steroid metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process relationship: negatively_regulates GO:0008202 ! steroid metabolic process [Term] id: GO:0045940 name: positive regulation of steroid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] subset: gosubset_prok synonym: "activation of steroid metabolic process" NARROW [] synonym: "positive regulation of steroid metabolism" EXACT [] synonym: "stimulation of steroid metabolic process" NARROW [] synonym: "up regulation of steroid metabolic process" EXACT [] synonym: "up-regulation of steroid metabolic process" EXACT [] synonym: "upregulation of steroid metabolic process" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process relationship: positively_regulates GO:0008202 ! steroid metabolic process [Term] id: GO:0045942 name: negative regulation of phosphorus utilization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of phosphorus utilization" EXACT [] synonym: "down-regulation of phosphorus utilization" EXACT [] synonym: "downregulation of phosphorus utilization" EXACT [] synonym: "inhibition of phosphorus utilization" NARROW [] is_a: GO:0006795 ! regulation of phosphorus utilization is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0006794 ! phosphorus utilization [Term] id: GO:0045943 name: positive regulation of transcription from RNA polymerase I promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase I promoter" NARROW [] synonym: "positive regulation of transcription from Pol I promoter" EXACT [] synonym: "stimulation of transcription from RNA polymerase I promoter" NARROW [] synonym: "up regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "up-regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "upregulation of transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent relationship: positively_regulates GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0045944 name: positive regulation of transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0010552 alt_id: GO:0045817 def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "activation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "activation of transcription from RNA polymerase II promoter" EXACT [] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "positive regulation of global transcription from Pol II promoter" RELATED [] synonym: "positive regulation of transcription from Pol II promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter, global" RELATED [] synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "upregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0045945 name: positive regulation of transcription from RNA polymerase III promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase III promoter" NARROW [] synonym: "positive regulation of transcription from Pol III promoter" EXACT [] synonym: "stimulation of transcription from RNA polymerase III promoter" NARROW [] synonym: "up regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "up-regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "upregulation of transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent relationship: positively_regulates GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0045947 name: negative regulation of translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of translational initiation" EXACT [] synonym: "down-regulation of translational initiation" EXACT [] synonym: "downregulation of translational initiation" EXACT [] synonym: "inhibition of translational initiation" NARROW [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0017148 ! negative regulation of translation relationship: negatively_regulates GO:0006413 ! translational initiation [Term] id: GO:0045948 name: positive regulation of translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators] subset: gosubset_prok synonym: "activation of translational initiation" NARROW [] synonym: "stimulation of translational initiation" NARROW [] synonym: "up regulation of translational initiation" EXACT [] synonym: "up-regulation of translational initiation" EXACT [] synonym: "upregulation of translational initiation" EXACT [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0045727 ! positive regulation of translation relationship: positively_regulates GO:0006413 ! translational initiation [Term] id: GO:0045949 name: positive regulation of phosphorus utilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] subset: gosubset_prok synonym: "activation of phosphorus utilization" NARROW [] synonym: "stimulation of phosphorus utilization" NARROW [] synonym: "up regulation of phosphorus utilization" EXACT [] synonym: "up-regulation of phosphorus utilization" EXACT [] synonym: "upregulation of phosphorus utilization" EXACT [] is_a: GO:0006795 ! regulation of phosphorus utilization is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0006794 ! phosphorus utilization [Term] id: GO:0045950 name: negative regulation of mitotic recombination namespace: biological_process def: "Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd] synonym: "down regulation of mitotic recombination" EXACT [] synonym: "down-regulation of mitotic recombination" EXACT [] synonym: "downregulation of mitotic recombination" EXACT [] synonym: "inhibition of mitotic recombination" NARROW [] synonym: "negative regulation of recombination within rDNA repeats" NARROW [] is_a: GO:0000019 ! regulation of mitotic recombination is_a: GO:0045910 ! negative regulation of DNA recombination relationship: negatively_regulates GO:0006312 ! mitotic recombination [Term] id: GO:0045951 name: positive regulation of mitotic recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] synonym: "activation of mitotic recombination" NARROW [] synonym: "positive regulation of recombination within rDNA repeats" NARROW [] synonym: "stimulation of mitotic recombination" NARROW [] synonym: "up regulation of mitotic recombination" EXACT [] synonym: "up-regulation of mitotic recombination" EXACT [] synonym: "upregulation of mitotic recombination" EXACT [] is_a: GO:0000019 ! regulation of mitotic recombination is_a: GO:0045911 ! positive regulation of DNA recombination relationship: positively_regulates GO:0006312 ! mitotic recombination [Term] id: GO:0045952 name: regulation of juvenile hormone catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone breakdown" EXACT [] synonym: "regulation of juvenile hormone catabolism" EXACT [] synonym: "regulation of juvenile hormone degradation" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0050994 ! regulation of lipid catabolic process relationship: regulates GO:0006719 ! juvenile hormone catabolic process [Term] id: GO:0045953 name: negative regulation of natural killer cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "down-regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "downregulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "inhibition of natural killer cell mediated cytotoxicity" NARROW [] synonym: "negative regulation of natural killer cell mediated cell death" EXACT [] synonym: "negative regulation of natural killer cell mediated cell killing" EXACT [] synonym: "negative regulation of natural killer cell mediated cytolysis" RELATED [] synonym: "negative regulation of NK cell mediated cell death" EXACT [] synonym: "negative regulation of NK cell mediated cell killing" EXACT [] synonym: "negative regulation of NK cell mediated cytolysis" RELATED [] synonym: "negative regulation of NK cell mediated cytotoxicity" EXACT [] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity relationship: negatively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0045954 name: positive regulation of natural killer cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of natural killer cell mediated cytotoxicity" NARROW [] synonym: "positive regulation of natural killer cell mediated cell death" EXACT [] synonym: "positive regulation of natural killer cell mediated cell killing" EXACT [] synonym: "positive regulation of natural killer cell mediated cytolysis" RELATED [] synonym: "positive regulation of NK cell mediated cell death" EXACT [] synonym: "positive regulation of NK cell mediated cell killing" EXACT [] synonym: "positive regulation of NK cell mediated cytolysis" RELATED [] synonym: "positive regulation of NK cell mediated cytotoxicity" EXACT [] synonym: "stimulation of natural killer cell mediated cytotoxicity" NARROW [] synonym: "up regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "up-regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "upregulation of natural killer cell mediated cytotoxicity" EXACT [] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity relationship: positively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0045955 name: negative regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] synonym: "down regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "down-regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "downregulation of calcium ion-dependent exocytosis" EXACT [] synonym: "inhibition of calcium ion-dependent exocytosis" NARROW [] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:0045920 ! negative regulation of exocytosis relationship: negatively_regulates GO:0017156 ! calcium ion-dependent exocytosis [Term] id: GO:0045956 name: positive regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] synonym: "activation of calcium ion-dependent exocytosis" NARROW [] synonym: "stimulation of calcium ion-dependent exocytosis" NARROW [] synonym: "up regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "up-regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "upregulation of calcium ion-dependent exocytosis" EXACT [] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:0045921 ! positive regulation of exocytosis relationship: positively_regulates GO:0017156 ! calcium ion-dependent exocytosis [Term] id: GO:0045957 name: negative regulation of complement activation, alternative pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators] synonym: "down regulation of complement activation, alternative pathway" EXACT [] synonym: "down-regulation of complement activation, alternative pathway" EXACT [] synonym: "downregulation of complement activation, alternative pathway" EXACT [] synonym: "inhibition of complement activation, alternative pathway" NARROW [] synonym: "negative regulation of complement cascade, alternative pathway" EXACT [GOC:add] is_a: GO:0030451 ! regulation of complement activation, alternative pathway is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0045916 ! negative regulation of complement activation relationship: negatively_regulates GO:0006957 ! complement activation, alternative pathway [Term] id: GO:0045958 name: positive regulation of complement activation, alternative pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators] synonym: "activation of complement activation, alternative pathway" NARROW [] synonym: "positive regulation of complement cascade, alternative pathway" EXACT [GOC:add] synonym: "stimulation of complement activation, alternative pathway" NARROW [] synonym: "up regulation of complement activation, alternative pathway" EXACT [] synonym: "up-regulation of complement activation, alternative pathway" EXACT [] synonym: "upregulation of complement activation, alternative pathway" EXACT [] is_a: GO:0030451 ! regulation of complement activation, alternative pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0045917 ! positive regulation of complement activation relationship: positively_regulates GO:0006957 ! complement activation, alternative pathway [Term] id: GO:0045959 name: negative regulation of complement activation, classical pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators] synonym: "down regulation of complement activation, classical pathway" EXACT [] synonym: "down-regulation of complement activation, classical pathway" EXACT [] synonym: "downregulation of complement activation, classical pathway" EXACT [] synonym: "inhibition of complement activation, classical pathway" NARROW [] synonym: "negative regulation of complement cascade, classical pathway" EXACT [GOC:add] is_a: GO:0030450 ! regulation of complement activation, classical pathway is_a: GO:0045916 ! negative regulation of complement activation relationship: negatively_regulates GO:0006958 ! complement activation, classical pathway [Term] id: GO:0045960 name: positive regulation of complement activation, classical pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators] synonym: "activation of complement activation, classical pathway" NARROW [] synonym: "positive regulation of complement cascade, classical pathway" EXACT [GOC:add] synonym: "stimulation of complement activation, classical pathway" NARROW [] synonym: "up regulation of complement activation, classical pathway" EXACT [] synonym: "up-regulation of complement activation, classical pathway" EXACT [] synonym: "upregulation of complement activation, classical pathway" EXACT [] is_a: GO:0030450 ! regulation of complement activation, classical pathway is_a: GO:0045917 ! positive regulation of complement activation relationship: positively_regulates GO:0006958 ! complement activation, classical pathway [Term] id: GO:0045961 name: negative regulation of development, heterochronic namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the progression an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition at a consistent predetermined time point during its development." [GOC:go_curators] synonym: "down regulation of development, heterochronic" EXACT [] synonym: "down-regulation of development, heterochronic" EXACT [] synonym: "downregulation of development, heterochronic" EXACT [] synonym: "inhibition of development, heterochronic" NARROW [] is_a: GO:0040034 ! regulation of development, heterochronic [Term] id: GO:0045962 name: positive regulation of development, heterochronic namespace: biological_process def: "Any process that increases the rate, frequency or extent of the progression an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition at a consistent predetermined time point during its development." [GOC:go_curators] synonym: "activation of development, heterochronic" NARROW [] synonym: "stimulation of development, heterochronic" NARROW [] synonym: "up regulation of development, heterochronic" EXACT [] synonym: "up-regulation of development, heterochronic" EXACT [] synonym: "upregulation of development, heterochronic" EXACT [] is_a: GO:0040034 ! regulation of development, heterochronic [Term] id: GO:0045963 name: negative regulation of dopamine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] synonym: "down regulation of dopamine metabolic process" EXACT [] synonym: "down-regulation of dopamine metabolic process" EXACT [] synonym: "downregulation of dopamine metabolic process" EXACT [] synonym: "inhibition of dopamine metabolic process" NARROW [] synonym: "negative regulation of dopamine metabolism" EXACT [] is_a: GO:0042053 ! regulation of dopamine metabolic process is_a: GO:0045914 ! negative regulation of catecholamine metabolic process relationship: negatively_regulates GO:0042417 ! dopamine metabolic process [Term] id: GO:0045964 name: positive regulation of dopamine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] synonym: "activation of dopamine metabolic process" NARROW [] synonym: "positive regulation of dopamine metabolism" EXACT [] synonym: "stimulation of dopamine metabolic process" NARROW [] synonym: "up regulation of dopamine metabolic process" EXACT [] synonym: "up-regulation of dopamine metabolic process" EXACT [] synonym: "upregulation of dopamine metabolic process" EXACT [] is_a: GO:0042053 ! regulation of dopamine metabolic process is_a: GO:0045915 ! positive regulation of catecholamine metabolic process relationship: positively_regulates GO:0042417 ! dopamine metabolic process [Term] id: GO:0045965 name: negative regulation of ecdysteroid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators] synonym: "down regulation of ecdysteroid metabolic process" EXACT [] synonym: "down-regulation of ecdysteroid metabolic process" EXACT [] synonym: "downregulation of ecdysteroid metabolic process" EXACT [] synonym: "inhibition of ecdysteroid metabolic process" NARROW [] synonym: "negative regulation of ecdysteroid metabolism" EXACT [] is_a: GO:0007553 ! regulation of ecdysteroid metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process relationship: negatively_regulates GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0045966 name: positive regulation of ecdysteroid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators] synonym: "activation of ecdysteroid metabolic process" NARROW [] synonym: "positive regulation of ecdysteroid metabolism" EXACT [] synonym: "stimulation of ecdysteroid metabolic process" NARROW [] synonym: "up regulation of ecdysteroid metabolic process" EXACT [] synonym: "up-regulation of ecdysteroid metabolic process" EXACT [] synonym: "upregulation of ecdysteroid metabolic process" EXACT [] is_a: GO:0007553 ! regulation of ecdysteroid metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process relationship: positively_regulates GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0045967 name: negative regulation of growth rate namespace: biological_process def: "Any process that reduces the rate of growth of all or part of an organism." [GOC:mah] comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. synonym: "down regulation of growth rate" EXACT [] synonym: "down-regulation of growth rate" EXACT [] synonym: "downregulation of growth rate" EXACT [] synonym: "inhibition of growth rate" NARROW [] is_a: GO:0040009 ! regulation of growth rate is_a: GO:0045926 ! negative regulation of growth [Term] id: GO:0045968 name: negative regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "down-regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "downregulation of juvenile hormone biosynthetic process" EXACT [] synonym: "inhibition of juvenile hormone biosynthetic process" NARROW [] synonym: "negative regulation of juvenile hormone anabolism" EXACT [] synonym: "negative regulation of juvenile hormone biosynthesis" EXACT [] synonym: "negative regulation of juvenile hormone formation" EXACT [] synonym: "negative regulation of juvenile hormone synthesis" EXACT [] is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process relationship: negatively_regulates GO:0006718 ! juvenile hormone biosynthetic process [Term] id: GO:0045969 name: positive regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone biosynthetic process" NARROW [] synonym: "positive regulation of juvenile hormone anabolism" EXACT [] synonym: "positive regulation of juvenile hormone biosynthesis" EXACT [] synonym: "positive regulation of juvenile hormone formation" EXACT [] synonym: "positive regulation of juvenile hormone synthesis" EXACT [] synonym: "stimulation of juvenile hormone biosynthetic process" NARROW [] synonym: "up regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "up-regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "upregulation of juvenile hormone biosynthetic process" EXACT [] is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process relationship: positively_regulates GO:0006718 ! juvenile hormone biosynthetic process [Term] id: GO:0045970 name: negative regulation of juvenile hormone catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone catabolic process" EXACT [] synonym: "down-regulation of juvenile hormone catabolic process" EXACT [] synonym: "downregulation of juvenile hormone catabolic process" EXACT [] synonym: "inhibition of juvenile hormone catabolic process" NARROW [] synonym: "negative regulation of juvenile hormone breakdown" EXACT [] synonym: "negative regulation of juvenile hormone catabolism" EXACT [] synonym: "negative regulation of juvenile hormone degradation" EXACT [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process is_a: GO:0045952 ! regulation of juvenile hormone catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process relationship: negatively_regulates GO:0006719 ! juvenile hormone catabolic process [Term] id: GO:0045971 name: positive regulation of juvenile hormone catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone catabolic process" NARROW [] synonym: "positive regulation of juvenile hormone breakdown" EXACT [] synonym: "positive regulation of juvenile hormone catabolism" EXACT [] synonym: "positive regulation of juvenile hormone degradation" EXACT [] synonym: "stimulation of juvenile hormone catabolic process" NARROW [] synonym: "up regulation of juvenile hormone catabolic process" EXACT [] synonym: "up-regulation of juvenile hormone catabolic process" EXACT [] synonym: "upregulation of juvenile hormone catabolic process" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process is_a: GO:0045952 ! regulation of juvenile hormone catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process relationship: positively_regulates GO:0006719 ! juvenile hormone catabolic process [Term] id: GO:0045972 name: negative regulation of juvenile hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone secretion" EXACT [] synonym: "down-regulation of juvenile hormone secretion" EXACT [] synonym: "downregulation of juvenile hormone secretion" EXACT [] synonym: "inhibition of juvenile hormone secretion" NARROW [] is_a: GO:0007558 ! regulation of juvenile hormone secretion is_a: GO:0046888 ! negative regulation of hormone secretion relationship: negatively_regulates GO:0045443 ! juvenile hormone secretion [Term] id: GO:0045973 name: positive regulation of juvenile hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone secretion" NARROW [] synonym: "stimulation of juvenile hormone secretion" NARROW [] synonym: "up regulation of juvenile hormone secretion" EXACT [] synonym: "up-regulation of juvenile hormone secretion" EXACT [] synonym: "upregulation of juvenile hormone secretion" EXACT [] is_a: GO:0007558 ! regulation of juvenile hormone secretion is_a: GO:0046887 ! positive regulation of hormone secretion relationship: positively_regulates GO:0045443 ! juvenile hormone secretion [Term] id: GO:0045974 name: regulation of translation, ncRNA-mediated namespace: biological_process def: "Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0006417 ! regulation of translation [Term] id: GO:0045975 name: positive regulation of translation, ncRNA-mediated namespace: biological_process def: "Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of mRNA translation, ncRNA-mediated" NARROW [] synonym: "stimulation of mRNA translation, ncRNA-mediated" NARROW [] synonym: "up regulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "up-regulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "upregulation of mRNA translation, ncRNA-mediated" EXACT [] is_a: GO:0045727 ! positive regulation of translation is_a: GO:0045974 ! regulation of translation, ncRNA-mediated [Term] id: GO:0045976 name: negative regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT [] synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT [] synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW [] synonym: "negative regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic is_a: GO:0045930 ! negative regulation of mitotic cell cycle relationship: negatively_regulates GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0045977 name: positive regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of mitotic cell cycle, embryonic" NARROW [] synonym: "positive regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of mitotic cell cycle, embryonic" NARROW [] synonym: "up regulation of mitotic cell cycle, embryonic" EXACT [] synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT [] synonym: "upregulation of mitotic cell cycle, embryonic" EXACT [] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic is_a: GO:0045931 ! positive regulation of mitotic cell cycle relationship: positively_regulates GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0045978 name: negative regulation of nucleoside metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of nucleoside metabolic process" EXACT [] synonym: "down-regulation of nucleoside metabolic process" EXACT [] synonym: "downregulation of nucleoside metabolic process" EXACT [] synonym: "inhibition of nucleoside metabolic process" NARROW [] synonym: "negative regulation of nucleoside metabolism" EXACT [] is_a: GO:0009118 ! regulation of nucleoside metabolic process is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: negatively_regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0045979 name: positive regulation of nucleoside metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] subset: gosubset_prok synonym: "activation of nucleoside metabolic process" NARROW [] synonym: "positive regulation of nucleoside metabolism" EXACT [] synonym: "stimulation of nucleoside metabolic process" NARROW [] synonym: "up regulation of nucleoside metabolic process" EXACT [] synonym: "up-regulation of nucleoside metabolic process" EXACT [] synonym: "upregulation of nucleoside metabolic process" EXACT [] is_a: GO:0009118 ! regulation of nucleoside metabolic process is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: positively_regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0045980 name: negative regulation of nucleotide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of nucleotide metabolic process" EXACT [] synonym: "down-regulation of nucleotide metabolic process" EXACT [] synonym: "downregulation of nucleotide metabolic process" EXACT [] synonym: "inhibition of nucleotide metabolic process" NARROW [] synonym: "negative regulation of nucleotide metabolism" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: negatively_regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0045981 name: positive regulation of nucleotide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] subset: gosubset_prok synonym: "activation of nucleotide metabolic process" NARROW [] synonym: "positive regulation of nucleotide metabolism" EXACT [] synonym: "stimulation of nucleotide metabolic process" NARROW [] synonym: "up regulation of nucleotide metabolic process" EXACT [] synonym: "up-regulation of nucleotide metabolic process" EXACT [] synonym: "upregulation of nucleotide metabolic process" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: positively_regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0045982 name: negative regulation of purine base metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of purine base metabolic process" EXACT [] synonym: "down-regulation of purine base metabolic process" EXACT [] synonym: "downregulation of purine base metabolic process" EXACT [] synonym: "inhibition of purine base metabolic process" NARROW [] synonym: "negative regulation of purine base metabolism" EXACT [] synonym: "negative regulation of purine nucleobase metabolic process" EXACT [CHEBI:26386] is_a: GO:0006141 ! regulation of purine base metabolic process is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: negatively_regulates GO:0006144 ! purine base metabolic process [Term] id: GO:0045983 name: positive regulation of purine base metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators] subset: gosubset_prok synonym: "activation of purine base metabolic process" NARROW [] synonym: "positive regulation of purine base metabolism" EXACT [] synonym: "positive regulation of purine nucleobase metabolic process" EXACT [CHEBI:26386] synonym: "stimulation of purine base metabolic process" NARROW [] synonym: "up regulation of purine base metabolic process" EXACT [] synonym: "up-regulation of purine base metabolic process" EXACT [] synonym: "upregulation of purine base metabolic process" EXACT [] is_a: GO:0006141 ! regulation of purine base metabolic process is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: positively_regulates GO:0006144 ! purine base metabolic process [Term] id: GO:0045984 name: negative regulation of pyrimidine base metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine bases." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of pyrimidine base metabolic process" EXACT [] synonym: "down-regulation of pyrimidine base metabolic process" EXACT [] synonym: "downregulation of pyrimidine base metabolic process" EXACT [] synonym: "inhibition of pyrimidine base metabolic process" NARROW [] synonym: "negative regulation of pyrimidine base metabolism" EXACT [] synonym: "negative regulation of pyrimidine nucleobase metabolic process" EXACT [CHEBI:26432] is_a: GO:0006142 ! regulation of pyrimidine base metabolic process is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: negatively_regulates GO:0006206 ! pyrimidine base metabolic process [Term] id: GO:0045985 name: positive regulation of pyrimidine base metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine bases." [GOC:go_curators] subset: gosubset_prok synonym: "activation of pyrimidine base metabolic process" NARROW [] synonym: "positive regulation of pyrimidine base metabolism" EXACT [] synonym: "positive regulation of pyrimidine nucleobase metabolic process" EXACT [CHEBI:26432] synonym: "stimulation of pyrimidine base metabolic process" NARROW [] synonym: "up regulation of pyrimidine base metabolic process" EXACT [] synonym: "up-regulation of pyrimidine base metabolic process" EXACT [] synonym: "upregulation of pyrimidine base metabolic process" EXACT [] is_a: GO:0006142 ! regulation of pyrimidine base metabolic process is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: positively_regulates GO:0006206 ! pyrimidine base metabolic process [Term] id: GO:0045986 name: negative regulation of smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "down regulation of smooth muscle contraction" EXACT [] synonym: "down-regulation of smooth muscle contraction" EXACT [] synonym: "downregulation of smooth muscle contraction" EXACT [] synonym: "inhibition of smooth muscle contraction" NARROW [] synonym: "smooth muscle relaxation" RELATED [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction relationship: negatively_regulates GO:0006939 ! smooth muscle contraction [Term] id: GO:0045987 name: positive regulation of smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "activation of smooth muscle contraction" NARROW [] synonym: "stimulation of smooth muscle contraction" NARROW [] synonym: "up regulation of smooth muscle contraction" EXACT [] synonym: "up-regulation of smooth muscle contraction" EXACT [] synonym: "upregulation of smooth muscle contraction" EXACT [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction relationship: positively_regulates GO:0006939 ! smooth muscle contraction [Term] id: GO:0045988 name: negative regulation of striated muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "down regulation of striated muscle contraction" EXACT [] synonym: "down-regulation of striated muscle contraction" EXACT [] synonym: "downregulation of striated muscle contraction" EXACT [] synonym: "inhibition of striated muscle contraction" NARROW [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction relationship: negatively_regulates GO:0006941 ! striated muscle contraction [Term] id: GO:0045989 name: positive regulation of striated muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "activation of striated muscle contraction" NARROW [] synonym: "stimulation of striated muscle contraction" NARROW [] synonym: "up regulation of striated muscle contraction" EXACT [] synonym: "up-regulation of striated muscle contraction" EXACT [] synonym: "upregulation of striated muscle contraction" EXACT [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction relationship: positively_regulates GO:0006941 ! striated muscle contraction [Term] id: GO:0045990 name: carbon catabolite regulation of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:go_curators, GOC:mah, PMID:18359269, PMID:9618445] subset: gosubset_prok synonym: "regulation of transcription by carbon catabolites" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0031670 ! cellular response to nutrient [Term] id: GO:0045991 name: carbon catabolite activation of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:mah, PMID:10559153] subset: gosubset_prok synonym: "positive regulation of transcription by carbon catabolites" EXACT [GOC:mah] is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0045992 name: negative regulation of embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "down regulation of embryonic development" EXACT [] synonym: "down-regulation of embryonic development" EXACT [] synonym: "downregulation of embryonic development" EXACT [] synonym: "inhibition of embryonic development" NARROW [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0009790 ! embryo development [Term] id: GO:0045993 name: negative regulation of translational initiation by iron namespace: biological_process def: "Any process involving iron that stops, prevents or reduces the rate of translational initiation." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of translational initiation by iron" EXACT [] synonym: "down-regulation of translational initiation by iron" EXACT [] synonym: "downregulation of translational initiation by iron" EXACT [] synonym: "inhibition of translational initiation by iron" NARROW [] is_a: GO:0006447 ! regulation of translational initiation by iron is_a: GO:0045947 ! negative regulation of translational initiation [Term] id: GO:0045994 name: positive regulation of translational initiation by iron namespace: biological_process def: "Any process involving iron that activates or increases the rate of translational initiation." [GOC:go_curators] subset: gosubset_prok synonym: "activation of translational initiation by iron" NARROW [] synonym: "stimulation of translational initiation by iron" NARROW [] synonym: "up regulation of translational initiation by iron" EXACT [] synonym: "up-regulation of translational initiation by iron" EXACT [] synonym: "upregulation of translational initiation by iron" EXACT [] is_a: GO:0006447 ! regulation of translational initiation by iron is_a: GO:0045948 ! positive regulation of translational initiation [Term] id: GO:0045995 name: regulation of embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0009790 ! embryo development [Term] id: GO:0045996 name: negative regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of transcription by pheromones" EXACT [] synonym: "down-regulation of transcription by pheromones" EXACT [] synonym: "downregulation of transcription by pheromones" EXACT [] synonym: "inhibition of transcription by pheromones" NARROW [] is_a: GO:0009373 ! regulation of transcription by pheromones is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0045997 name: negative regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "down regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "down-regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "downregulation of ecdysteroid biosynthetic process" EXACT [] synonym: "inhibition of ecdysteroid biosynthetic process" NARROW [] synonym: "negative regulation of ecdysteroid anabolism" EXACT [] synonym: "negative regulation of ecdysteroid biosynthesis" EXACT [] synonym: "negative regulation of ecdysteroid formation" EXACT [] synonym: "negative regulation of ecdysteroid synthesis" EXACT [] is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process is_a: GO:0045965 ! negative regulation of ecdysteroid metabolic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process relationship: negatively_regulates GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0045998 name: positive regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "activation of ecdysteroid biosynthetic process" NARROW [] synonym: "positive regulation of ecdysteroid anabolism" EXACT [] synonym: "positive regulation of ecdysteroid biosynthesis" EXACT [] synonym: "positive regulation of ecdysteroid formation" EXACT [] synonym: "positive regulation of ecdysteroid synthesis" EXACT [] synonym: "stimulation of ecdysteroid biosynthetic process" NARROW [] synonym: "up regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "up-regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "upregulation of ecdysteroid biosynthetic process" EXACT [] is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process is_a: GO:0045966 ! positive regulation of ecdysteroid metabolic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process relationship: positively_regulates GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0045999 name: negative regulation of ecdysteroid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] synonym: "down regulation of ecdysteroid secretion" EXACT [] synonym: "down-regulation of ecdysteroid secretion" EXACT [] synonym: "downregulation of ecdysteroid secretion" EXACT [] synonym: "inhibition of ecdysteroid secretion" NARROW [] is_a: GO:0007555 ! regulation of ecdysteroid secretion is_a: GO:0046888 ! negative regulation of hormone secretion relationship: negatively_regulates GO:0045457 ! ecdysteroid secretion [Term] id: GO:0046000 name: positive regulation of ecdysteroid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] synonym: "activation of ecdysteroid secretion" NARROW [] synonym: "stimulation of ecdysteroid secretion" NARROW [] synonym: "up regulation of ecdysteroid secretion" EXACT [] synonym: "up-regulation of ecdysteroid secretion" EXACT [] synonym: "upregulation of ecdysteroid secretion" EXACT [] is_a: GO:0007555 ! regulation of ecdysteroid secretion is_a: GO:0046887 ! positive regulation of hormone secretion relationship: positively_regulates GO:0045457 ! ecdysteroid secretion [Term] id: GO:0046001 name: negative regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW [] synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic relationship: negatively_regulates GO:0035185 ! preblastoderm mitotic cell cycle [Term] id: GO:0046002 name: positive regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW [] synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW [] synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT [] is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic relationship: positively_regulates GO:0035185 ! preblastoderm mitotic cell cycle [Term] id: GO:0046003 name: negative regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW [] synonym: "negative regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT [] is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic relationship: negatively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle [Term] id: GO:0046004 name: positive regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] synonym: "positive regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic relationship: positively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle [Term] id: GO:0046005 name: positive regulation of circadian sleep/wake cycle, REM sleep namespace: biological_process def: "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators] synonym: "activation of circadian sleep/wake cycle, REM sleep" NARROW [] synonym: "positive regulation of REM sleep" EXACT [] synonym: "stimulation of circadian sleep/wake cycle, REM sleep" NARROW [] synonym: "up regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "up-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "upregulation of circadian sleep/wake cycle, REM sleep" EXACT [] is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep relationship: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep [Term] id: GO:0046006 name: regulation of activated T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activated T cell proliferation." [GOC:go_curators] synonym: "regulation of activated T lymphocyte proliferation" EXACT [] synonym: "regulation of activated T-cell proliferation" EXACT [] synonym: "regulation of activated T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation relationship: regulates GO:0050798 ! activated T cell proliferation [Term] id: GO:0046007 name: negative regulation of activated T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation." [GOC:go_curators] synonym: "down regulation of activated T cell proliferation" EXACT [] synonym: "down-regulation of activated T cell proliferation" EXACT [] synonym: "downregulation of activated T cell proliferation" EXACT [] synonym: "inhibition of activated T cell proliferation" NARROW [] synonym: "negative regulation of activated T lymphocyte proliferation" EXACT [] synonym: "negative regulation of activated T-cell proliferation" EXACT [] synonym: "negative regulation of activated T-lymphocyte proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046006 ! regulation of activated T cell proliferation relationship: negatively_regulates GO:0050798 ! activated T cell proliferation [Term] id: GO:0046008 name: regulation of female receptivity, post-mating namespace: biological_process def: "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] is_a: GO:0045297 ! post-mating behavior is_a: GO:0045924 ! regulation of female receptivity [Term] id: GO:0046009 name: positive regulation of female receptivity, post-mating namespace: biological_process def: "Any process that increases the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] synonym: "activation of female receptivity, post-mating" NARROW [] synonym: "stimulation of female receptivity, post-mating" NARROW [] synonym: "up regulation of female receptivity, post-mating" EXACT [] synonym: "up-regulation of female receptivity, post-mating" EXACT [] synonym: "upregulation of female receptivity, post-mating" EXACT [] is_a: GO:0045925 ! positive regulation of female receptivity is_a: GO:0046008 ! regulation of female receptivity, post-mating [Term] id: GO:0046010 name: positive regulation of circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:go_curators] synonym: "activation of circadian sleep/wake cycle, non-REM sleep" NARROW [] synonym: "positive regulation of non-REM sleep" EXACT [] synonym: "stimulation of circadian sleep/wake cycle, non-REM sleep" NARROW [] synonym: "up regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "up-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "upregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep relationship: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0046011 name: regulation of oskar mRNA translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512] is_a: GO:0006417 ! regulation of translation [Term] id: GO:0046012 name: positive regulation of oskar mRNA translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators] synonym: "activation of oskar mRNA translation" NARROW [] synonym: "stimulation of oskar mRNA translation" NARROW [] synonym: "up regulation of oskar mRNA translation" EXACT [] synonym: "up-regulation of oskar mRNA translation" EXACT [] synonym: "upregulation of oskar mRNA translation" EXACT [] is_a: GO:0045727 ! positive regulation of translation is_a: GO:0046011 ! regulation of oskar mRNA translation [Term] id: GO:0046013 name: regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators] synonym: "regulation of resting T cell proliferation" EXACT [] synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "regulation of T-cell homeostatic proliferation" EXACT [] synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0042129 ! regulation of T cell proliferation relationship: regulates GO:0001777 ! T cell homeostatic proliferation [Term] id: GO:0046014 name: negative regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators] synonym: "down regulation of T cell homeostatic proliferation" EXACT [] synonym: "down-regulation of T cell homeostatic proliferation" EXACT [] synonym: "downregulation of T cell homeostatic proliferation" EXACT [] synonym: "inhibition of T cell homeostatic proliferation" NARROW [] synonym: "negative regulation of resting T cell proliferation" EXACT [] synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "negative regulation of T-cell homeostatic proliferation" EXACT [] synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046013 ! regulation of T cell homeostatic proliferation relationship: negatively_regulates GO:0001777 ! T cell homeostatic proliferation [Term] id: GO:0046015 name: regulation of transcription by glucose namespace: biological_process def: "Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] subset: gosubset_prok is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0046016 name: positive regulation of transcription by glucose namespace: biological_process def: "Any process involving glucose that activates or increases the rate of transcription." [GOC:go_curators] subset: gosubset_prok synonym: "activation of transcription by glucose" NARROW [] synonym: "stimulation of transcription by glucose" NARROW [] synonym: "up regulation of transcription by glucose" EXACT [] synonym: "up-regulation of transcription by glucose" EXACT [] synonym: "upregulation of transcription by glucose" EXACT [] is_a: GO:0045991 ! carbon catabolite activation of transcription is_a: GO:0046015 ! regulation of transcription by glucose [Term] id: GO:0046017 name: regulation of transcription from RNA polymerase I promoter, mitotic namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] synonym: "mitotic regulation of transcription from Pol I promoter" EXACT [] synonym: "regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:dph, GOC:tb] synonym: "regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:dph, GOC:tb] is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter is_a: GO:0045896 ! regulation of transcription during mitosis [Term] id: GO:0046018 name: positive regulation of transcription from RNA polymerase I promoter during mitosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic activation of transcription from Pol I promoter" EXACT [] synonym: "positive regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah] synonym: "positive regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah] synonym: "stimulation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] synonym: "up regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "up-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "upregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] is_a: GO:0045897 ! positive regulation of transcription during mitosis is_a: GO:0045943 ! positive regulation of transcription from RNA polymerase I promoter is_a: GO:0046017 ! regulation of transcription from RNA polymerase I promoter, mitotic [Term] id: GO:0046019 name: regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "regulation of transcription from Pol II promoter by pheromones" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0009373 ! regulation of transcription by pheromones [Term] id: GO:0046020 name: negative regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "negative regulation of transcription from Pol II promoter by pheromones" EXACT [] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0045996 ! negative regulation of transcription by pheromones is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones [Term] id: GO:0046021 name: regulation of transcription from RNA polymerase II promoter, mitotic namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] synonym: "mitotic regulation of transcription from Pol II promoter" EXACT [] synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:dph, GOC:tb] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045896 ! regulation of transcription during mitosis [Term] id: GO:0046022 name: positive regulation of transcription from RNA polymerase II promoter during mitosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic activation of transcription from Pol II promoter" EXACT [] synonym: "positive regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah] synonym: "positive regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah] synonym: "stimulation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] synonym: "up regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "up-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "upregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] is_a: GO:0045897 ! positive regulation of transcription during mitosis is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0046021 ! regulation of transcription from RNA polymerase II promoter, mitotic [Term] id: GO:0046023 name: regulation of transcription from RNA polymerase III promoter, mitotic namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] synonym: "mitotic regulation of transcription from Pol III promoter" EXACT [] synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT [] synonym: "regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:dph, GOC:tb] is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter is_a: GO:0045896 ! regulation of transcription during mitosis [Term] id: GO:0046024 name: positive regulation of transcription from RNA polymerase III promoter during mitosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic activation of transcription from Pol III promoter" EXACT [] synonym: "positive regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah] synonym: "positive regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah] synonym: "stimulation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] synonym: "up regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "up-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "upregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] is_a: GO:0045897 ! positive regulation of transcription during mitosis is_a: GO:0045945 ! positive regulation of transcription from RNA polymerase III promoter is_a: GO:0046023 ! regulation of transcription from RNA polymerase III promoter, mitotic [Term] id: GO:0046025 name: precorrin-6Y C5,15-methyltransferase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2." [EC:2.1.1.132] subset: gosubset_prok synonym: "precorrin-6 methyltransferase activity" BROAD [EC:2.1.1.132] synonym: "precorrin-6Y methylase activity" BROAD [EC:2.1.1.132] synonym: "S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)" EXACT [EC:2.1.1.132] xref: EC:2.1.1.132 xref: MetaCyc:2.1.1.132-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0046026 name: precorrin-4 C11-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5." [EC:2.1.1.133] subset: gosubset_prok synonym: "CobM" RELATED [EC:2.1.1.133] synonym: "S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity" EXACT [EC:2.1.1.133] xref: EC:2.1.1.133 xref: MetaCyc:2.1.1.133-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0046027 name: phospholipid:diacylglycerol acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158] synonym: "PDAT activity" EXACT [EC:2.3.1.158] synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.158] xref: EC:2.3.1.158 xref: MetaCyc:2.3.1.158-RXN is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0046028 name: electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity namespace: molecular_function def: "Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] synonym: "plastocyanin" NARROW [] is_a: GO:0009055 ! electron carrier activity [Term] id: GO:0046029 name: mannitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH." [EC:1.1.1.255, RHEA:15032] synonym: "mannitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.255] synonym: "MTD activity" EXACT [EC:1.1.1.255] synonym: "NAD-dependent mannitol dehydrogenase activity" BROAD [EC:1.1.1.255] xref: EC:1.1.1.255 xref: KEGG:R07135 xref: MetaCyc:1.1.1.255-RXN xref: RHEA:15032 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: GO:0031320 ! hexitol dehydrogenase activity [Term] id: GO:0046030 name: inositol trisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the removal of one of the three phosphate groups of an inositol trisphosphate." [GOC:bf] synonym: "inositol-1,4,5-trisphosphate phosphatase" NARROW [] synonym: "IP(3) phosphatase activity" EXACT [] synonym: "IP3 phosphatase activity" EXACT [] is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0046031 name: ADP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "ADP metabolism" EXACT [] is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process [Term] id: GO:0046032 name: ADP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "ADP breakdown" EXACT [] synonym: "ADP catabolism" EXACT [] synonym: "ADP degradation" EXACT [] is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0046033 name: AMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "adenylate forming enzyme activity" RELATED [] synonym: "AMP metabolism" EXACT [] is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0046034 name: ATP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] subset: gosubset_prok synonym: "ATP metabolism" EXACT [] is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0046035 name: CMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CMP, cytidine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "CMP metabolism" EXACT [] is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process [Term] id: GO:0046036 name: CTP metabolic process namespace: biological_process alt_id: GO:0006243 def: "The chemical reactions and pathways involving CTP, cytidine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "CTP deamination" NARROW [] synonym: "CTP metabolism" EXACT [] is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process [Term] id: GO:0046037 name: GMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GMP, guanosine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "GMP metabolism" EXACT [] is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0046038 name: GMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "GMP breakdown" EXACT [] synonym: "GMP catabolism" EXACT [] synonym: "GMP degradation" EXACT [] is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0046037 ! GMP metabolic process [Term] id: GO:0046039 name: GTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GTP, guanosine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "GTP metabolism" EXACT [] is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0046040 name: IMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving IMP, inosine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "IMP metabolism" EXACT [] is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0046041 name: ITP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ITP, inosine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "ITP metabolism" EXACT [] is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0046042 name: ITP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "ITP anabolism" EXACT [] synonym: "ITP biosynthesis" EXACT [] synonym: "ITP formation" EXACT [] synonym: "ITP synthesis" EXACT [] is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046041 ! ITP metabolic process [Term] id: GO:0046043 name: TDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving TDP, ribosylthymine diphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "TDP metabolism" EXACT [] is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process [Term] id: GO:0046044 name: TMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving TMP, ribosylthymine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "TMP metabolism" EXACT [] is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process [Term] id: GO:0046045 name: TMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "TMP breakdown" EXACT [] synonym: "TMP catabolism" EXACT [] synonym: "TMP degradation" EXACT [] is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process is_a: GO:0046044 ! TMP metabolic process [Term] id: GO:0046046 name: TTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving TTP, ribosylthymine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "TTP metabolism" EXACT [] is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process [Term] id: GO:0046047 name: TTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "TTP breakdown" EXACT [] synonym: "TTP catabolism" EXACT [] synonym: "TTP degradation" EXACT [] synonym: "TTP hydrolysis" EXACT [] is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process is_a: GO:0046046 ! TTP metabolic process [Term] id: GO:0046048 name: UDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "UDP metabolism" EXACT [] is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process [Term] id: GO:0046049 name: UMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UMP, uridine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "UMP metabolism" EXACT [] is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process [Term] id: GO:0046050 name: UMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "UMP breakdown" EXACT [] synonym: "UMP catabolism" EXACT [] synonym: "UMP degradation" EXACT [] is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process is_a: GO:0046049 ! UMP metabolic process [Term] id: GO:0046051 name: UTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "UTP metabolism" EXACT [] is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process [Term] id: GO:0046052 name: UTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "UTP breakdown" EXACT [] synonym: "UTP catabolism" EXACT [] synonym: "UTP degradation" EXACT [] synonym: "UTP hydrolysis" EXACT [] is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process is_a: GO:0046051 ! UTP metabolic process [Term] id: GO:0046053 name: dAMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dAMP metabolism" EXACT [] is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0046054 name: dGMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dGMP metabolism" EXACT [] is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0046055 name: dGMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dGMP breakdown" EXACT [] synonym: "dGMP catabolism" EXACT [] synonym: "dGMP degradation" EXACT [] is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process is_a: GO:0046054 ! dGMP metabolic process [Term] id: GO:0046056 name: dADP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dADP metabolism" EXACT [] is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0046057 name: dADP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dADP breakdown" EXACT [] synonym: "dADP catabolism" EXACT [] synonym: "dADP degradation" EXACT [] is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0046058 name: cAMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "3',5' cAMP metabolic process" EXACT [] synonym: "3',5' cAMP metabolism" EXACT [] synonym: "3',5'-cAMP metabolic process" EXACT [] synonym: "3',5'-cAMP metabolism" EXACT [] synonym: "adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "cAMP generating peptide activity" RELATED [] synonym: "cAMP metabolism" EXACT [] synonym: "cyclic AMP metabolic process" EXACT [] synonym: "cyclic AMP metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0046059 name: dAMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dAMP breakdown" EXACT [] synonym: "dAMP catabolism" EXACT [] synonym: "dAMP degradation" EXACT [] is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process is_a: GO:0046053 ! dAMP metabolic process [Term] id: GO:0046060 name: dATP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dATP metabolism" EXACT [] is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0046061 name: dATP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dATP breakdown" EXACT [] synonym: "dATP catabolism" EXACT [] synonym: "dATP degradation" EXACT [] is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046060 ! dATP metabolic process [Term] id: GO:0046062 name: dCDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dCDP metabolism" EXACT [] is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0046063 name: dCMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dCMP metabolism" EXACT [] is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0046064 name: dCMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dCMP anabolism" EXACT [] synonym: "dCMP biosynthesis" EXACT [] synonym: "dCMP formation" EXACT [] synonym: "dCMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046063 ! dCMP metabolic process [Term] id: GO:0046065 name: dCTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dCTP metabolism" EXACT [] is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0046066 name: dGDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dGDP metabolism" EXACT [] is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0046067 name: dGDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dGDP breakdown" EXACT [] synonym: "dGDP catabolism" EXACT [] synonym: "dGDP degradation" EXACT [] is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0046068 name: cGMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators] subset: gosubset_prok synonym: "cGMP metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0046069 name: cGMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators] subset: gosubset_prok synonym: "cGMP breakdown" EXACT [] synonym: "cGMP catabolism" EXACT [] synonym: "cGMP degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009214 ! cyclic nucleotide catabolic process is_a: GO:0046068 ! cGMP metabolic process [Term] id: GO:0046070 name: dGTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dGTP, guanosine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dGTP metabolism" EXACT [] is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0046071 name: dGTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dGTP anabolism" EXACT [] synonym: "dGTP biosynthesis" EXACT [] synonym: "dGTP formation" EXACT [] synonym: "dGTP synthesis" EXACT [] is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046070 ! dGTP metabolic process [Term] id: GO:0046072 name: dTDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dTDP metabolism" EXACT [] is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0046073 name: dTMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dTMP metabolism" EXACT [] is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0046074 name: dTMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dTMP breakdown" EXACT [] synonym: "dTMP catabolism" EXACT [] synonym: "dTMP degradation" EXACT [] is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process is_a: GO:0046073 ! dTMP metabolic process [Term] id: GO:0046075 name: dTTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dTTP metabolism" EXACT [] is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0046076 name: dTTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dTTP breakdown" EXACT [] synonym: "dTTP catabolism" EXACT [] synonym: "dTTP degradation" EXACT [] is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046075 ! dTTP metabolic process [Term] id: GO:0046077 name: dUDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dUDP metabolism" EXACT [] is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0046078 name: dUMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "dUMP metabolism" EXACT [] is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0046079 name: dUMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dUMP breakdown" EXACT [] synonym: "dUMP catabolism" EXACT [] synonym: "dUMP degradation" EXACT [] is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process is_a: GO:0046078 ! dUMP metabolic process [Term] id: GO:0046080 name: dUTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dUTP metabolism" EXACT [] is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0046081 name: dUTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dUTP breakdown" EXACT [] synonym: "dUTP catabolism" EXACT [] synonym: "dUTP degradation" EXACT [] is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046080 ! dUTP metabolic process [Term] id: GO:0046082 name: 5-methylcytosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "5-methylcytosine anabolism" EXACT [] synonym: "5-methylcytosine biosynthesis" EXACT [] synonym: "5-methylcytosine formation" EXACT [] synonym: "5-methylcytosine synthesis" EXACT [] is_a: GO:0019856 ! pyrimidine base biosynthetic process is_a: GO:0019857 ! 5-methylcytosine metabolic process [Term] id: GO:0046083 name: adenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators] subset: gosubset_prok synonym: "adenine metabolism" EXACT [] is_a: GO:0006144 ! purine base metabolic process [Term] id: GO:0046084 name: adenine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators] subset: gosubset_prok synonym: "adenine anabolism" EXACT [] synonym: "adenine biosynthesis" EXACT [] synonym: "adenine formation" EXACT [] synonym: "adenine synthesis" EXACT [] is_a: GO:0009113 ! purine base biosynthetic process is_a: GO:0046083 ! adenine metabolic process [Term] id: GO:0046085 name: adenosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] subset: gosubset_prok synonym: "adenosine metabolism" EXACT [] is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046086 name: adenosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] subset: gosubset_prok synonym: "adenosine anabolism" EXACT [] synonym: "adenosine biosynthesis" EXACT [] synonym: "adenosine formation" EXACT [] synonym: "adenosine synthesis" EXACT [] is_a: GO:0046085 ! adenosine metabolic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0046087 name: cytidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators] subset: gosubset_prok synonym: "cytidine metabolism" EXACT [] is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process [Term] id: GO:0046088 name: cytidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators] subset: gosubset_prok synonym: "cytidine anabolism" EXACT [] synonym: "cytidine biosynthesis" EXACT [] synonym: "cytidine formation" EXACT [] synonym: "cytidine synthesis" EXACT [] is_a: GO:0046087 ! cytidine metabolic process is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process [Term] id: GO:0046089 name: cytosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] subset: gosubset_prok synonym: "cytosine anabolism" EXACT [] synonym: "cytosine biosynthesis" EXACT [] synonym: "cytosine formation" EXACT [] synonym: "cytosine synthesis" EXACT [] is_a: GO:0019856 ! pyrimidine base biosynthetic process is_a: GO:0019858 ! cytosine metabolic process [Term] id: GO:0046090 name: deoxyadenosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyadenosine metabolism" EXACT [] is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0046091 name: deoxyadenosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyadenosine anabolism" EXACT [] synonym: "deoxyadenosine biosynthesis" EXACT [] synonym: "deoxyadenosine formation" EXACT [] synonym: "deoxyadenosine synthesis" EXACT [] is_a: GO:0046090 ! deoxyadenosine metabolic process is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process [Term] id: GO:0046092 name: deoxycytidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxycytidine metabolism" EXACT [] is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0046093 name: deoxycytidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxycytidine anabolism" EXACT [] synonym: "deoxycytidine biosynthesis" EXACT [] synonym: "deoxycytidine formation" EXACT [] synonym: "deoxycytidine synthesis" EXACT [] is_a: GO:0046092 ! deoxycytidine metabolic process is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process [Term] id: GO:0046094 name: deoxyinosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyinosine metabolism" EXACT [] is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0046095 name: deoxyinosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyinosine anabolism" EXACT [] synonym: "deoxyinosine biosynthesis" EXACT [] synonym: "deoxyinosine formation" EXACT [] synonym: "deoxyinosine synthesis" EXACT [] is_a: GO:0046094 ! deoxyinosine metabolic process is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process [Term] id: GO:0046096 name: deoxyuridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyuridine metabolism" EXACT [] is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0046097 name: deoxyuridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyuridine anabolism" EXACT [] synonym: "deoxyuridine biosynthesis" EXACT [] synonym: "deoxyuridine formation" EXACT [] synonym: "deoxyuridine synthesis" EXACT [] is_a: GO:0046096 ! deoxyuridine metabolic process is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process [Term] id: GO:0046098 name: guanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] subset: gosubset_prok synonym: "guanine metabolism" EXACT [] is_a: GO:0006144 ! purine base metabolic process [Term] id: GO:0046099 name: guanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] subset: gosubset_prok synonym: "guanine anabolism" EXACT [] synonym: "guanine biosynthesis" EXACT [] synonym: "guanine formation" EXACT [] synonym: "guanine synthesis" EXACT [] is_a: GO:0009113 ! purine base biosynthetic process is_a: GO:0046098 ! guanine metabolic process [Term] id: GO:0046100 name: hypoxanthine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] subset: gosubset_prok synonym: "hypoxanthine metabolism" EXACT [] is_a: GO:0006144 ! purine base metabolic process [Term] id: GO:0046101 name: hypoxanthine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] subset: gosubset_prok synonym: "hypoxanthine anabolism" EXACT [] synonym: "hypoxanthine biosynthesis" EXACT [] synonym: "hypoxanthine formation" EXACT [] synonym: "hypoxanthine synthesis" EXACT [] is_a: GO:0009113 ! purine base biosynthetic process is_a: GO:0046100 ! hypoxanthine metabolic process [Term] id: GO:0046102 name: inosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] subset: gosubset_prok synonym: "inosine metabolism" EXACT [] is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046103 name: inosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] subset: gosubset_prok synonym: "inosine anabolism" EXACT [] synonym: "inosine biosynthesis" EXACT [] synonym: "inosine formation" EXACT [] synonym: "inosine synthesis" EXACT [] is_a: GO:0046102 ! inosine metabolic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0046104 name: thymidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyribosylthymine metabolic process" EXACT [] synonym: "deoxyribosylthymine metabolism" EXACT [] synonym: "thymidine metabolism" EXACT [] is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0046105 name: thymidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyribosylthymine biosynthesis" EXACT [] synonym: "deoxyribosylthymine biosynthetic process" EXACT [] synonym: "thymidine anabolism" EXACT [] synonym: "thymidine biosynthesis" EXACT [] synonym: "thymidine formation" EXACT [] synonym: "thymidine synthesis" EXACT [] is_a: GO:0046104 ! thymidine metabolic process is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process [Term] id: GO:0046106 name: thymine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] subset: gosubset_prok synonym: "thymine anabolism" EXACT [] synonym: "thymine biosynthesis" EXACT [] synonym: "thymine formation" EXACT [] synonym: "thymine synthesis" EXACT [] is_a: GO:0019856 ! pyrimidine base biosynthetic process is_a: GO:0019859 ! thymine metabolic process [Term] id: GO:0046107 name: uracil biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] subset: gosubset_prok synonym: "uracil anabolism" EXACT [] synonym: "uracil biosynthesis" EXACT [] synonym: "uracil formation" EXACT [] synonym: "uracil synthesis" EXACT [] is_a: GO:0019856 ! pyrimidine base biosynthetic process is_a: GO:0019860 ! uracil metabolic process [Term] id: GO:0046108 name: uridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "uridine metabolism" EXACT [] is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process [Term] id: GO:0046109 name: uridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "uridine anabolism" EXACT [] synonym: "uridine biosynthesis" EXACT [] synonym: "uridine formation" EXACT [] synonym: "uridine synthesis" EXACT [] is_a: GO:0046108 ! uridine metabolic process is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process [Term] id: GO:0046110 name: xanthine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "xanthine metabolism" EXACT [] is_a: GO:0006144 ! purine base metabolic process [Term] id: GO:0046111 name: xanthine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "xanthine anabolism" EXACT [] synonym: "xanthine biosynthesis" EXACT [] synonym: "xanthine formation" EXACT [] synonym: "xanthine synthesis" EXACT [] is_a: GO:0009113 ! purine base biosynthetic process is_a: GO:0046110 ! xanthine metabolic process [Term] id: GO:0046112 name: nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] subset: gosubset_prok synonym: "nucleobase anabolism" EXACT [] synonym: "nucleobase biosynthesis" EXACT [] synonym: "nucleobase formation" EXACT [] synonym: "nucleobase synthesis" EXACT [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process [Term] id: GO:0046113 name: nucleobase catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] subset: gosubset_prok synonym: "nucleobase breakdown" EXACT [] synonym: "nucleobase catabolism" EXACT [] synonym: "nucleobase degradation" EXACT [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0034656 ! nucleobase, nucleoside and nucleotide catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046114 name: guanosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators] subset: gosubset_prok synonym: "guanosine anabolism" EXACT [] synonym: "guanosine biosynthesis" EXACT [] synonym: "guanosine formation" EXACT [] synonym: "guanosine synthesis" EXACT [] is_a: GO:0008617 ! guanosine metabolic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0046115 name: guanosine catabolic process namespace: biological_process alt_id: GO:0006160 def: "The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators] subset: gosubset_prok synonym: "guanosine breakdown" EXACT [] synonym: "guanosine catabolism" EXACT [] synonym: "guanosine degradation" EXACT [] synonym: "guanosine phosphorolysis" RELATED [] is_a: GO:0008617 ! guanosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0046116 name: queuosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "queuosine metabolism" EXACT [] is_a: GO:0008618 ! 7-methylguanosine metabolic process [Term] id: GO:0046117 name: queuosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "queuosine breakdown" EXACT [] synonym: "queuosine catabolism" EXACT [] synonym: "queuosine degradation" EXACT [] is_a: GO:0046116 ! queuosine metabolic process is_a: GO:0046119 ! 7-methylguanosine catabolic process [Term] id: GO:0046118 name: 7-methylguanosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "7-methylguanosine anabolism" EXACT [] synonym: "7-methylguanosine biosynthesis" EXACT [] synonym: "7-methylguanosine formation" EXACT [] synonym: "7-methylguanosine synthesis" EXACT [] is_a: GO:0008618 ! 7-methylguanosine metabolic process is_a: GO:0046114 ! guanosine biosynthetic process [Term] id: GO:0046119 name: 7-methylguanosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "7-methylguanosine breakdown" EXACT [] synonym: "7-methylguanosine catabolism" EXACT [] synonym: "7-methylguanosine degradation" EXACT [] is_a: GO:0008618 ! 7-methylguanosine metabolic process is_a: GO:0046115 ! guanosine catabolic process [Term] id: GO:0046120 name: deoxyribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "deoxyribonucleoside anabolism" EXACT [] synonym: "deoxyribonucleoside biosynthesis" EXACT [] synonym: "deoxyribonucleoside formation" EXACT [] synonym: "deoxyribonucleoside synthesis" EXACT [] is_a: GO:0009120 ! deoxyribonucleoside metabolic process is_a: GO:0009163 ! nucleoside biosynthetic process [Term] id: GO:0046121 name: deoxyribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "deoxyribonucleoside breakdown" EXACT [] synonym: "deoxyribonucleoside catabolism" EXACT [] synonym: "deoxyribonucleoside degradation" EXACT [] is_a: GO:0009120 ! deoxyribonucleoside metabolic process is_a: GO:0009164 ! nucleoside catabolic process [Term] id: GO:0046122 name: purine deoxyribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "purine deoxyribonucleoside metabolism" EXACT [] is_a: GO:0009120 ! deoxyribonucleoside metabolic process is_a: GO:0042278 ! purine nucleoside metabolic process [Term] id: GO:0046123 name: purine deoxyribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "purine deoxyribonucleoside anabolism" EXACT [] synonym: "purine deoxyribonucleoside biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside formation" EXACT [] synonym: "purine deoxyribonucleoside synthesis" EXACT [] is_a: GO:0042451 ! purine nucleoside biosynthetic process is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0046124 name: purine deoxyribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "purine deoxyribonucleoside breakdown" EXACT [] synonym: "purine deoxyribonucleoside catabolism" EXACT [] synonym: "purine deoxyribonucleoside degradation" EXACT [] is_a: GO:0006152 ! purine nucleoside catabolic process is_a: GO:0046121 ! deoxyribonucleoside catabolic process is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0046125 name: pyrimidine deoxyribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside metabolism" EXACT [] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process [Term] id: GO:0046126 name: pyrimidine deoxyribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process [Term] id: GO:0046127 name: pyrimidine deoxyribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside degradation" EXACT [] is_a: GO:0046121 ! deoxyribonucleoside catabolic process is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process is_a: GO:0046135 ! pyrimidine nucleoside catabolic process [Term] id: GO:0046128 name: purine ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] subset: gosubset_prok synonym: "purine ribonucleoside metabolism" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0042278 ! purine nucleoside metabolic process [Term] id: GO:0046129 name: purine ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] subset: gosubset_prok synonym: "purine ribonucleoside anabolism" EXACT [] synonym: "purine ribonucleoside biosynthesis" EXACT [] synonym: "purine ribonucleoside formation" EXACT [] synonym: "purine ribonucleoside synthesis" EXACT [] is_a: GO:0042451 ! purine nucleoside biosynthetic process is_a: GO:0042455 ! ribonucleoside biosynthetic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046130 name: purine ribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] subset: gosubset_prok synonym: "purine ribonucleoside breakdown" EXACT [] synonym: "purine ribonucleoside catabolism" EXACT [] synonym: "purine ribonucleoside degradation" EXACT [] is_a: GO:0006152 ! purine nucleoside catabolic process is_a: GO:0042454 ! ribonucleoside catabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046131 name: pyrimidine ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] subset: gosubset_prok synonym: "pyrimidine ribonucleoside metabolism" EXACT [] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0009119 ! ribonucleoside metabolic process [Term] id: GO:0046132 name: pyrimidine ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] subset: gosubset_prok synonym: "pyrimidine ribonucleoside anabolism" EXACT [] synonym: "pyrimidine ribonucleoside biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside formation" EXACT [] synonym: "pyrimidine ribonucleoside synthesis" EXACT [] is_a: GO:0042455 ! ribonucleoside biosynthetic process is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process [Term] id: GO:0046133 name: pyrimidine ribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] subset: gosubset_prok synonym: "pyrimidine ribonucleoside breakdown" EXACT [] synonym: "pyrimidine ribonucleoside catabolism" EXACT [] synonym: "pyrimidine ribonucleoside degradation" EXACT [] is_a: GO:0042454 ! ribonucleoside catabolic process is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process is_a: GO:0046135 ! pyrimidine nucleoside catabolic process [Term] id: GO:0046134 name: pyrimidine nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "pyrimidine nucleoside anabolism" EXACT [] synonym: "pyrimidine nucleoside biosynthesis" EXACT [] synonym: "pyrimidine nucleoside formation" EXACT [] synonym: "pyrimidine nucleoside synthesis" EXACT [] xref: Reactome:1252989 "Pyrimidine biosynthesis" xref: Reactome:1279920 "Pyrimidine biosynthesis" xref: Reactome:1298815 "Pyrimidine biosynthesis" xref: Reactome:1326493 "Pyrimidine biosynthesis" xref: Reactome:1352600 "Pyrimidine biosynthesis" xref: Reactome:1372832 "Pyrimidine biosynthesis" xref: Reactome:1392844 "Pyrimidine biosynthesis" xref: Reactome:1417320 "Pyrimidine biosynthesis" xref: Reactome:1450406 "Pyrimidine biosynthesis" xref: Reactome:1470937 "Pyrimidine biosynthesis" xref: Reactome:1482977 "Pyrimidine biosynthesis" xref: Reactome:1496749 "Pyrimidine biosynthesis" xref: Reactome:1514139 "Pyrimidine biosynthesis" xref: Reactome:1520965 "Pyrimidine biosynthesis" xref: Reactome:1526717 "Pyrimidine biosynthesis" xref: Reactome:1532441 "Pyrimidine biosynthesis" xref: Reactome:1535993 "Pyrimidine biosynthesis" xref: Reactome:1537993 "Pyrimidine biosynthesis" xref: Reactome:1539246 "Pyrimidine biosynthesis" xref: Reactome:1540296 "Pyrimidine biosynthesis" xref: Reactome:500753 "Pyrimidine biosynthesis" is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0046135 name: pyrimidine nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai] subset: gosubset_prok synonym: "pyrimidine nucleoside breakdown" EXACT [] synonym: "pyrimidine nucleoside catabolism" EXACT [] synonym: "pyrimidine nucleoside degradation" EXACT [] xref: Reactome:1252992 "Pyrimidine catabolism" xref: Reactome:1279922 "Pyrimidine catabolism" xref: Reactome:1298817 "Pyrimidine catabolism" xref: Reactome:1326496 "Pyrimidine catabolism" xref: Reactome:1352603 "Pyrimidine catabolism" xref: Reactome:1372835 "Pyrimidine catabolism" xref: Reactome:1392847 "Pyrimidine catabolism" xref: Reactome:1417322 "Pyrimidine catabolism" xref: Reactome:1450409 "Pyrimidine catabolism" xref: Reactome:1470940 "Pyrimidine catabolism" xref: Reactome:1482980 "Pyrimidine catabolism" xref: Reactome:1496752 "Pyrimidine catabolism" xref: Reactome:1514142 "Pyrimidine catabolism" xref: Reactome:1520968 "Pyrimidine catabolism" xref: Reactome:1537996 "Pyrimidine catabolism" xref: Reactome:1539307 "Pyrimidine catabolism" xref: Reactome:1540313 "Pyrimidine catabolism" xref: Reactome:73621 "Pyrimidine catabolism" is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0009164 ! nucleoside catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0046136 name: positive regulation of vitamin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: gosubset_prok synonym: "activation of vitamin metabolic process" NARROW [] synonym: "positive regulation of vitamin metabolism" EXACT [] synonym: "stimulation of vitamin metabolic process" NARROW [] synonym: "up regulation of vitamin metabolic process" EXACT [] synonym: "up-regulation of vitamin metabolic process" EXACT [] synonym: "upregulation of vitamin metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0030656 ! regulation of vitamin metabolic process relationship: positively_regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0046137 name: negative regulation of vitamin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: gosubset_prok synonym: "down regulation of vitamin metabolic process" EXACT [] synonym: "down-regulation of vitamin metabolic process" EXACT [] synonym: "downregulation of vitamin metabolic process" EXACT [] synonym: "inhibition of vitamin metabolic process" NARROW [] synonym: "negative regulation of vitamin metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0030656 ! regulation of vitamin metabolic process relationship: negatively_regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0046138 name: coenzyme and prosthetic group biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "coenzyme and prosthetic group anabolism" EXACT [] synonym: "coenzyme and prosthetic group biosynthesis" EXACT [] synonym: "coenzyme and prosthetic group formation" EXACT [] synonym: "coenzyme and prosthetic group synthesis" EXACT [] is_obsolete: true consider: GO:0009108 consider: GO:0051191 [Term] id: GO:0046139 name: coenzyme and prosthetic group catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "coenzyme and prosthetic group breakdown" EXACT [] synonym: "coenzyme and prosthetic group catabolism" EXACT [] synonym: "coenzyme and prosthetic group degradation" EXACT [] is_obsolete: true consider: GO:0009109 consider: GO:0051190 [Term] id: GO:0046140 name: corrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai] subset: gosubset_prok synonym: "corrin anabolism" EXACT [] synonym: "corrin biosynthesis" EXACT [] synonym: "corrin formation" EXACT [] synonym: "corrin synthesis" EXACT [] is_a: GO:0015009 ! corrin metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0046141 name: corrin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai] subset: gosubset_prok synonym: "corrin breakdown" EXACT [] synonym: "corrin catabolism" EXACT [] synonym: "corrin degradation" EXACT [] is_a: GO:0015009 ! corrin metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0046142 name: negative regulation of coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. is_obsolete: true consider: GO:0051198 consider: GO:0051201 [Term] id: GO:0046143 name: positive regulation of coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. is_obsolete: true consider: GO:0051197 consider: GO:0051200 [Term] id: GO:0046144 name: D-alanine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-alanine and related amino acids." [GOC:ai] subset: gosubset_prok synonym: "D-alanine family amino acid metabolism" EXACT [] is_a: GO:0006522 ! alanine metabolic process [Term] id: GO:0046145 name: D-alanine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids." [GOC:ai] subset: gosubset_prok synonym: "D-alanine family amino acid anabolism" EXACT [] synonym: "D-alanine family amino acid biosynthesis" EXACT [] synonym: "D-alanine family amino acid formation" EXACT [] synonym: "D-alanine family amino acid synthesis" EXACT [] is_a: GO:0006523 ! alanine biosynthetic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process [Term] id: GO:0046146 name: tetrahydrobiopterin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "5,6,7,8-tetrahydrobiopterin metabolic process" EXACT [CHEBI:15372, GOC:curators] synonym: "tetrahydrobiopterin metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0046147 name: tetrahydrobiopterin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "5,6,7,8-tetrahydrobiopterin catabolic process" EXACT [CHEBI:15372, GOC:curators] synonym: "tetrahydrobiopterin breakdown" EXACT [] synonym: "tetrahydrobiopterin catabolism" EXACT [] synonym: "tetrahydrobiopterin degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process is_a: GO:0046146 ! tetrahydrobiopterin metabolic process [Term] id: GO:0046148 name: pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pigment anabolism" EXACT [] synonym: "pigment biosynthesis" EXACT [] synonym: "pigment formation" EXACT [] synonym: "pigment synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0046149 name: pigment catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pigment breakdown" EXACT [] synonym: "pigment catabolism" EXACT [] synonym: "pigment degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0046150 name: melanin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "melanin breakdown" EXACT [] synonym: "melanin catabolism" EXACT [] synonym: "melanin degradation" EXACT [] is_a: GO:0006582 ! melanin metabolic process is_a: GO:0046149 ! pigment catabolic process [Term] id: GO:0046151 name: eye pigment catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] synonym: "eye pigment breakdown" EXACT [] synonym: "eye pigment catabolism" EXACT [] synonym: "eye pigment degradation" EXACT [] is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0046149 ! pigment catabolic process [Term] id: GO:0046152 name: ommochrome metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ommochrome metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0046158 ! ocellus pigment metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046153 name: ommochrome catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ommochrome breakdown" EXACT [] synonym: "ommochrome catabolism" EXACT [] synonym: "ommochrome degradation" EXACT [] is_a: GO:0046151 ! eye pigment catabolic process is_a: GO:0046152 ! ommochrome metabolic process is_a: GO:0046159 ! ocellus pigment catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046154 name: rhodopsin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "rhodopsin metabolism" EXACT [] is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0046155 name: rhodopsin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "rhodopsin breakdown" EXACT [] synonym: "rhodopsin catabolism" EXACT [] synonym: "rhodopsin degradation" EXACT [] is_a: GO:0044257 ! cellular protein catabolic process is_a: GO:0046151 ! eye pigment catabolic process is_a: GO:0046154 ! rhodopsin metabolic process [Term] id: GO:0046156 name: siroheme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sirohaem metabolic process" EXACT [] synonym: "sirohaem metabolism" EXACT [] synonym: "siroheme metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0046157 name: siroheme catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sirohaem catabolic process" EXACT [] synonym: "sirohaem catabolism" EXACT [] synonym: "siroheme breakdown" EXACT [] synonym: "siroheme catabolism" EXACT [] synonym: "siroheme degradation" EXACT [] is_a: GO:0042167 ! heme catabolic process is_a: GO:0046156 ! siroheme metabolic process [Term] id: GO:0046158 name: ocellus pigment metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] synonym: "ocellus pigment metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0043474 ! pigment metabolic process involved in pigmentation relationship: part_of GO:0033060 ! ocellus pigmentation [Term] id: GO:0046159 name: ocellus pigment catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] synonym: "ocellus pigment breakdown" EXACT [] synonym: "ocellus pigment catabolism" EXACT [] synonym: "ocellus pigment degradation" EXACT [] is_a: GO:0046149 ! pigment catabolic process is_a: GO:0046158 ! ocellus pigment metabolic process [Term] id: GO:0046160 name: heme a metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3." [CHEBI:24479, GOC:curators] subset: gosubset_prok synonym: "haem a metabolic process" EXACT [] synonym: "haem a metabolism" EXACT [] synonym: "heme a metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0046161 name: heme a catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3." [CHEBI:24479, GOC:curators] subset: gosubset_prok synonym: "haem a catabolic process" EXACT [] synonym: "haem a catabolism" EXACT [] synonym: "heme a breakdown" EXACT [] synonym: "heme a catabolism" EXACT [] synonym: "heme a degradation" EXACT [] is_a: GO:0042167 ! heme catabolic process is_a: GO:0046160 ! heme a metabolic process [Term] id: GO:0046162 name: heme c metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208] subset: gosubset_prok synonym: "haem c metabolic process" EXACT [] synonym: "haem c metabolism" EXACT [] synonym: "heme c metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0046163 name: heme c catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208] subset: gosubset_prok synonym: "haem c catabolic process" EXACT [] synonym: "haem c catabolism" EXACT [] synonym: "heme c breakdown" EXACT [] synonym: "heme c catabolism" EXACT [] synonym: "heme c degradation" EXACT [] is_a: GO:0042167 ! heme catabolic process is_a: GO:0046162 ! heme c metabolic process [Term] id: GO:0046164 name: alcohol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, GOC:ai] subset: gosubset_prok synonym: "alcohol breakdown" EXACT [] synonym: "alcohol catabolism" EXACT [] synonym: "alcohol degradation" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0046165 name: alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, GOC:ai] subset: gosubset_prok synonym: "alcohol anabolism" EXACT [] synonym: "alcohol biosynthesis" EXACT [] synonym: "alcohol formation" EXACT [] synonym: "alcohol synthesis" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0046166 name: glyceraldehyde-3-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai] subset: gosubset_prok synonym: "glyceraldehyde 3-phosphate biosynthesis" EXACT [] synonym: "glyceraldehyde 3-phosphate biosynthetic process" EXACT [] synonym: "glyceraldehyde-3-phosphate anabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate biosynthesis" EXACT [] synonym: "glyceraldehyde-3-phosphate formation" EXACT [] synonym: "glyceraldehyde-3-phosphate synthesis" EXACT [] is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process is_a: GO:0046184 ! aldehyde biosynthetic process [Term] id: GO:0046167 name: glycerol-3-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai] subset: gosubset_prok synonym: "glycerol-3-phosphate anabolism" EXACT [] synonym: "glycerol-3-phosphate biosynthesis" EXACT [] synonym: "glycerol-3-phosphate formation" EXACT [] synonym: "glycerol-3-phosphate synthesis" EXACT [] is_a: GO:0006072 ! glycerol-3-phosphate metabolic process is_a: GO:0006114 ! glycerol biosynthetic process [Term] id: GO:0046168 name: glycerol-3-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai] subset: gosubset_prok synonym: "glycerol-3-phosphate breakdown" EXACT [] synonym: "glycerol-3-phosphate catabolism" EXACT [] synonym: "glycerol-3-phosphate degradation" EXACT [] is_a: GO:0006072 ! glycerol-3-phosphate metabolic process is_a: GO:0019563 ! glycerol catabolic process [Term] id: GO:0046169 name: methanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai] subset: gosubset_prok synonym: "methanol anabolism" EXACT [] synonym: "methanol biosynthesis" EXACT [] synonym: "methanol formation" EXACT [] synonym: "methanol synthesis" EXACT [] is_a: GO:0015945 ! methanol metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0046170 name: methanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai] subset: gosubset_prok synonym: "methanol breakdown" EXACT [] synonym: "methanol catabolism" EXACT [] synonym: "methanol degradation" EXACT [] is_a: GO:0015945 ! methanol metabolic process is_a: GO:0034310 ! primary alcohol catabolic process [Term] id: GO:0046171 name: octanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai] subset: gosubset_prok synonym: "octanol anabolism" EXACT [] synonym: "octanol biosynthesis" EXACT [] synonym: "octanol formation" EXACT [] synonym: "octanol synthesis" EXACT [] is_a: GO:0006070 ! octanol metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0046172 name: octanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai] subset: gosubset_prok synonym: "octanol breakdown" EXACT [] synonym: "octanol catabolism" EXACT [] synonym: "octanol degradation" EXACT [] is_a: GO:0006070 ! octanol metabolic process is_a: GO:0034310 ! primary alcohol catabolic process [Term] id: GO:0046173 name: polyol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [CHEBI:26191] subset: gosubset_prok synonym: "polyhydric alcohol biosynthetic process" EXACT [] synonym: "polyol anabolism" EXACT [] synonym: "polyol biosynthesis" EXACT [] synonym: "polyol formation" EXACT [] synonym: "polyol synthesis" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0046174 name: polyol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [CHEBI:26191] subset: gosubset_prok synonym: "polyhydric alcohol catabolic process" EXACT [] synonym: "polyol breakdown" EXACT [] synonym: "polyol catabolism" EXACT [] synonym: "polyol degradation" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0046175 name: aldonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aldonic acid anabolism" EXACT [] synonym: "aldonic acid biosynthesis" EXACT [] synonym: "aldonic acid formation" EXACT [] synonym: "aldonic acid synthesis" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process [Term] id: GO:0046176 name: aldonic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aldonic acid breakdown" EXACT [] synonym: "aldonic acid catabolism" EXACT [] synonym: "aldonic acid degradation" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046177 name: D-gluconate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-gluconate breakdown" EXACT [] synonym: "D-gluconate catabolism" EXACT [] synonym: "D-gluconate degradation" EXACT [] xref: MetaCyc:GLUCONSUPER-PWY is_a: GO:0019521 ! D-gluconate metabolic process is_a: GO:0046176 ! aldonic acid catabolic process [Term] id: GO:0046178 name: D-gluconate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-gluconate anabolism" EXACT [] synonym: "D-gluconate biosynthesis" EXACT [] synonym: "D-gluconate formation" EXACT [] synonym: "D-gluconate synthesis" EXACT [] is_a: GO:0019521 ! D-gluconate metabolic process is_a: GO:0046175 ! aldonic acid biosynthetic process [Term] id: GO:0046179 name: D-dehydro-D-gluconate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-dehydro-D-gluconate anabolism" EXACT [] synonym: "D-dehydro-D-gluconate biosynthesis" EXACT [] synonym: "D-dehydro-D-gluconate formation" EXACT [] synonym: "D-dehydro-D-gluconate synthesis" EXACT [] is_a: GO:0019525 ! D-dehydro-D-gluconate metabolic process is_a: GO:0046175 ! aldonic acid biosynthetic process [Term] id: GO:0046180 name: ketogluconate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ketogluconate anabolism" EXACT [] synonym: "ketogluconate biosynthesis" EXACT [] synonym: "ketogluconate formation" EXACT [] synonym: "ketogluconate synthesis" EXACT [] is_a: GO:0019522 ! ketogluconate metabolic process is_a: GO:0046175 ! aldonic acid biosynthetic process [Term] id: GO:0046181 name: ketogluconate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ketogluconate breakdown" EXACT [] synonym: "ketogluconate catabolism" EXACT [] synonym: "ketogluconate degradation" EXACT [] is_a: GO:0019522 ! ketogluconate metabolic process is_a: GO:0046176 ! aldonic acid catabolic process [Term] id: GO:0046182 name: L-idonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [CHEBI:17796, GOC:curators] subset: gosubset_prok synonym: "L-idonate anabolism" EXACT [] synonym: "L-idonate biosynthesis" EXACT [] synonym: "L-idonate formation" EXACT [] synonym: "L-idonate synthesis" EXACT [] is_a: GO:0019523 ! L-idonate metabolic process is_a: GO:0046180 ! ketogluconate biosynthetic process [Term] id: GO:0046183 name: L-idonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [CHEBI:17796, GOC:curators] subset: gosubset_prok synonym: "L-idonate breakdown" EXACT [] synonym: "L-idonate catabolism" EXACT [] synonym: "L-idonate degradation" EXACT [] is_a: GO:0019523 ! L-idonate metabolic process is_a: GO:0046181 ! ketogluconate catabolic process [Term] id: GO:0046184 name: aldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] subset: gosubset_prok synonym: "aldehyde anabolism" EXACT [] synonym: "aldehyde biosynthesis" EXACT [] synonym: "aldehyde formation" EXACT [] synonym: "aldehyde synthesis" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0046185 name: aldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] subset: gosubset_prok synonym: "aldehyde breakdown" EXACT [] synonym: "aldehyde catabolism" EXACT [] synonym: "aldehyde degradation" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0046186 name: acetaldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai] subset: gosubset_prok synonym: "acetaldehyde anabolism" EXACT [] synonym: "acetaldehyde biosynthesis" EXACT [] synonym: "acetaldehyde formation" EXACT [] synonym: "acetaldehyde synthesis" EXACT [] is_a: GO:0006117 ! acetaldehyde metabolic process is_a: GO:0046184 ! aldehyde biosynthetic process [Term] id: GO:0046187 name: acetaldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai] subset: gosubset_prok synonym: "acetaldehyde breakdown" EXACT [] synonym: "acetaldehyde catabolism" EXACT [] synonym: "acetaldehyde degradation" EXACT [] is_a: GO:0006117 ! acetaldehyde metabolic process is_a: GO:0046185 ! aldehyde catabolic process [Term] id: GO:0046188 name: methane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] subset: gosubset_prok synonym: "methane breakdown" EXACT [] synonym: "methane catabolism" EXACT [] synonym: "methane degradation" EXACT [] is_a: GO:0015947 ! methane metabolic process is_a: GO:0043448 ! alkane catabolic process [Term] id: GO:0046189 name: phenol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [CHEBI:33853, GOC:ai] subset: gosubset_prok synonym: "phenol-containing compound anabolism" EXACT [GOC:curators] synonym: "phenol-containing compound biosynthesis" EXACT [GOC:curators] synonym: "phenol-containing compound formation" EXACT [GOC:curators] synonym: "phenol-containing compound synthesis" EXACT [GOC:curators] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0046190 name: aerobic phenol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [CHEBI:33853, GOC:ai] subset: gosubset_prok synonym: "aerobic phenol-containing compound anabolism" EXACT [GOC:curators] synonym: "aerobic phenol-containing compound biosynthesis" EXACT [GOC:curators] synonym: "aerobic phenol-containing compound formation" EXACT [GOC:curators] synonym: "aerobic phenol-containing compound synthesis" EXACT [GOC:curators] is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0046191 name: aerobic phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [CHEBI:33853, GOC:ai] subset: gosubset_prok synonym: "aerobic phenol-containing compound breakdown" EXACT [GOC:curators] synonym: "aerobic phenol-containing compound catabolism" EXACT [GOC:curators] synonym: "aerobic phenol-containing compound degradation" EXACT [GOC:curators] is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process [Term] id: GO:0046192 name: anaerobic phenol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [CHEBI:33853, GOC:ai] subset: gosubset_prok synonym: "anaerobic phenol-containing compound anabolism" EXACT [GOC:curators] synonym: "anaerobic phenol-containing compound biosynthesis" EXACT [GOC:curators] synonym: "anaerobic phenol-containing compound formation" EXACT [GOC:curators] synonym: "anaerobic phenol-containing compound synthesis" EXACT [GOC:curators] is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0046193 name: anaerobic phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [CHEBI:33853, GOC:ai] subset: gosubset_prok synonym: "anaerobic phenol-containing compound breakdown" EXACT [GOC:curators] synonym: "anaerobic phenol-containing compound catabolism" EXACT [GOC:curators] synonym: "anaerobic phenol-containing compound degradation" EXACT [GOC:curators] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process [Term] id: GO:0046194 name: pentachlorophenol biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:ai] comment: This term was made obsolete because pentachlorophenol is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "pentachlorophenol anabolism" EXACT [] synonym: "pentachlorophenol biosynthesis" EXACT [] synonym: "pentachlorophenol formation" EXACT [] synonym: "pentachlorophenol synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018961 [Term] id: GO:0046195 name: 4-nitrophenol biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai] comment: This term was made obsolete because 4-nitrophenol is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "4-nitrophenol anabolism" EXACT [] synonym: "4-nitrophenol biosynthesis" EXACT [] synonym: "4-nitrophenol formation" EXACT [] synonym: "4-nitrophenol synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018960 [Term] id: GO:0046196 name: 4-nitrophenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai] subset: gosubset_prok synonym: "4-nitrophenol breakdown" EXACT [] synonym: "4-nitrophenol catabolism" EXACT [] synonym: "4-nitrophenol degradation" EXACT [] is_a: GO:0018960 ! 4-nitrophenol metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0046197 name: orcinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:ai] subset: gosubset_prok synonym: "orcinol anabolism" EXACT [] synonym: "orcinol biosynthesis" EXACT [] synonym: "orcinol formation" EXACT [] synonym: "orcinol synthesis" EXACT [] is_a: GO:0018940 ! orcinol metabolic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0046198 name: cresol biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai] comment: This term was made obsolete because cresol is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "cresol anabolism" EXACT [] synonym: "cresol biosynthesis" EXACT [] synonym: "cresol formation" EXACT [] synonym: "cresol synthesis" EXACT [] is_obsolete: true replaced_by: GO:0042212 [Term] id: GO:0046199 name: cresol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai] subset: gosubset_prok synonym: "cresol breakdown" EXACT [] synonym: "cresol catabolism" EXACT [] synonym: "cresol degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042212 ! cresol metabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0046200 name: m-cresol biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:ai] comment: This term was made obsolete because m-cresol is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "m-cresol anabolism" EXACT [] synonym: "m-cresol biosynthesis" EXACT [] synonym: "m-cresol formation" EXACT [] synonym: "m-cresol synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018925 [Term] id: GO:0046201 name: cyanate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid." [GOC:ai] subset: gosubset_prok synonym: "cyanate anabolism" EXACT [] synonym: "cyanate biosynthesis" EXACT [] synonym: "cyanate formation" EXACT [] synonym: "cyanate synthesis" EXACT [] is_a: GO:0009439 ! cyanate metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0046202 name: cyanide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [GOC:ai] subset: gosubset_prok synonym: "cyanide anabolism" EXACT [] synonym: "cyanide biosynthesis" EXACT [] synonym: "cyanide formation" EXACT [] synonym: "cyanide synthesis" EXACT [] is_a: GO:0019499 ! cyanide metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0046203 name: spermidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] subset: gosubset_prok synonym: "spermidine breakdown" EXACT [] synonym: "spermidine catabolism" EXACT [] synonym: "spermidine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0008216 ! spermidine metabolic process [Term] id: GO:0046204 name: nor-spermidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] subset: gosubset_prok synonym: "nor-spermidine metabolism" EXACT [] is_a: GO:0008216 ! spermidine metabolic process [Term] id: GO:0046205 name: nor-spermidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] subset: gosubset_prok synonym: "nor-spermidine breakdown" EXACT [] synonym: "nor-spermidine catabolism" EXACT [] synonym: "nor-spermidine degradation" EXACT [] is_a: GO:0046203 ! spermidine catabolic process is_a: GO:0046204 ! nor-spermidine metabolic process [Term] id: GO:0046206 name: trypanothione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai] subset: gosubset_prok synonym: "trypanothione metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0046207 name: trypanothione catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai] subset: gosubset_prok synonym: "trypanothione breakdown" EXACT [] synonym: "trypanothione catabolism" EXACT [] synonym: "trypanothione degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0046206 ! trypanothione metabolic process [Term] id: GO:0046208 name: spermine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [CHEBI:15746, GOC:curators] subset: gosubset_prok synonym: "spermine breakdown" EXACT [] synonym: "spermine catabolism" EXACT [] synonym: "spermine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0008215 ! spermine metabolic process [Term] id: GO:0046209 name: nitric oxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] subset: gosubset_prok synonym: "nitric oxide metabolism" EXACT [] xref: Reactome:1253542 "Metabolism of nitric oxide" xref: Reactome:1280481 "Metabolism of nitric oxide" xref: Reactome:1299305 "Metabolism of nitric oxide" xref: Reactome:1327059 "Metabolism of nitric oxide" xref: Reactome:1353153 "Metabolism of nitric oxide" xref: Reactome:1417849 "Metabolism of nitric oxide" xref: Reactome:1450944 "Metabolism of nitric oxide" xref: Reactome:1471326 "Metabolism of nitric oxide" xref: Reactome:1521241 "Metabolism of nitric oxide" xref: Reactome:1538068 "Metabolism of nitric oxide" xref: Reactome:1540352 "Metabolism of nitric oxide" xref: Reactome:202131 "Metabolism of nitric oxide" is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0046210 name: nitric oxide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] subset: gosubset_prok synonym: "nitric oxide breakdown" EXACT [] synonym: "nitric oxide catabolism" EXACT [] synonym: "nitric oxide degradation" EXACT [] is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046209 ! nitric oxide metabolic process [Term] id: GO:0046211 name: (+)-camphor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone." [GOC:ai] subset: gosubset_prok synonym: "(+)-camphor anabolism" EXACT [] synonym: "(+)-camphor biosynthesis" EXACT [] synonym: "(+)-camphor formation" EXACT [] synonym: "(+)-camphor synthesis" EXACT [] is_a: GO:0018882 ! (+)-camphor metabolic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0043693 ! monoterpene biosynthetic process [Term] id: GO:0046212 name: methyl ethyl ketone biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [GOC:ai] comment: This term was made obsolete because methyl ethyl ketone is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "methyl ethyl ketone anabolism" EXACT [] synonym: "methyl ethyl ketone biosynthesis" EXACT [] synonym: "methyl ethyl ketone formation" EXACT [] synonym: "methyl ethyl ketone synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018928 [Term] id: GO:0046213 name: methyl ethyl ketone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor." [GOC:ai] subset: gosubset_prok synonym: "methyl ethyl ketone breakdown" EXACT [] synonym: "methyl ethyl ketone catabolism" EXACT [] synonym: "methyl ethyl ketone degradation" EXACT [] is_a: GO:0018928 ! methyl ethyl ketone metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042182 ! ketone catabolic process [Term] id: GO:0046214 name: enterobactin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:ai] subset: gosubset_prok synonym: "enterobactin breakdown" EXACT [] synonym: "enterobactin catabolism" EXACT [] synonym: "enterobactin degradation" EXACT [] is_a: GO:0009238 ! enterobactin metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046215 ! siderophore catabolic process [Term] id: GO:0046215 name: siderophore catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:ai] subset: gosubset_prok synonym: "siderochrome catabolism" NARROW [] synonym: "siderophore breakdown" EXACT [] synonym: "siderophore catabolism" EXACT [] synonym: "siderophore degradation" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0046216 name: indole phytoalexin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai] subset: gosubset_prok synonym: "indole phytoalexin breakdown" EXACT [] synonym: "indole phytoalexin catabolism" EXACT [] synonym: "indole phytoalexin degradation" EXACT [] is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:0046217 ! indole phytoalexin metabolic process is_a: GO:0052316 ! phytoalexin catabolic process [Term] id: GO:0046217 name: indole phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai] subset: gosubset_prok synonym: "indole phytoalexin metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0046218 name: indolalkylamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [CHEBI:38631, GOC:curators] subset: gosubset_prok synonym: "indolalkylamine breakdown" EXACT [] synonym: "indolalkylamine catabolism" EXACT [] synonym: "indolalkylamine degradation" EXACT [] is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0042436 ! indole-containing compound catabolic process [Term] id: GO:0046219 name: indolalkylamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [CHEBI:38631, GOC:curators] subset: gosubset_prok synonym: "indolalkylamine anabolism" EXACT [] synonym: "indolalkylamine biosynthesis" EXACT [] synonym: "indolalkylamine formation" EXACT [] synonym: "indolalkylamine synthesis" EXACT [] is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0042435 ! indole-containing compound biosynthetic process [Term] id: GO:0046220 name: pyridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [CHEBI:16227, GOC:ai] subset: gosubset_prok synonym: "pyridine anabolism" EXACT [] synonym: "pyridine biosynthesis" EXACT [] synonym: "pyridine formation" EXACT [] synonym: "pyridine synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019507 ! pyridine metabolic process [Term] id: GO:0046221 name: pyridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [CHEBI:16227, GOC:ai] subset: gosubset_prok synonym: "pyridine breakdown" EXACT [] synonym: "pyridine catabolism" EXACT [] synonym: "pyridine degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019507 ! pyridine metabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046222 name: aflatoxin metabolic process namespace: biological_process alt_id: GO:0043389 def: "The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai] subset: gosubset_prok synonym: "aflatoxin B metabolic process" NARROW [GOC:mah] synonym: "aflatoxin metabolism" EXACT [] is_a: GO:0009804 ! coumarin metabolic process is_a: GO:0043385 ! mycotoxin metabolic process [Term] id: GO:0046223 name: aflatoxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai] subset: gosubset_prok synonym: "aflatoxin breakdown" EXACT [] synonym: "aflatoxin catabolism" EXACT [] synonym: "aflatoxin degradation" EXACT [] is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0046222 ! aflatoxin metabolic process is_a: GO:0046226 ! coumarin catabolic process [Term] id: GO:0046224 name: bacteriocin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai] subset: gosubset_prok synonym: "bacteriocin metabolism" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0030650 ! peptide antibiotic metabolic process [Term] id: GO:0046225 name: bacteriocin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai] subset: gosubset_prok synonym: "bacteriocin breakdown" EXACT [] synonym: "bacteriocin catabolism" EXACT [] synonym: "bacteriocin degradation" EXACT [] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0046224 ! bacteriocin metabolic process [Term] id: GO:0046226 name: coumarin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:ai] subset: gosubset_prok synonym: "coumarin breakdown" EXACT [] synonym: "coumarin catabolism" EXACT [] synonym: "coumarin degradation" EXACT [] is_a: GO:0009804 ! coumarin metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046227 name: 2,4,5-trichlorophenoxyacetic acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai] comment: This term was made obsolete because 2,4,5-trichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "2,4,5-trichlorophenoxyacetic acid anabolism" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid biosynthesis" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid formation" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018980 [Term] id: GO:0046228 name: 2,4,5-trichlorophenoxyacetic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai] subset: gosubset_prok synonym: "2,4,5-trichlorophenoxyacetic acid breakdown" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid catabolism" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid degradation" EXACT [] is_a: GO:0018980 ! 2,4,5-trichlorophenoxyacetic acid metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046229 name: 2-aminobenzenesulfonate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai] comment: This term was made obsolete because 2-aminobenzenesulfonate is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "2-aminobenzenesulfonate anabolism" EXACT [] synonym: "2-aminobenzenesulfonate biosynthesis" EXACT [] synonym: "2-aminobenzenesulfonate formation" EXACT [] synonym: "2-aminobenzenesulfonate synthesis" EXACT [] synonym: "2-aminobenzenesulphonate biosynthesis" EXACT [] synonym: "2-aminobenzenesulphonate biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018868 [Term] id: GO:0046230 name: 2-aminobenzenesulfonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai] subset: gosubset_prok synonym: "2-aminobenzenesulfonate breakdown" EXACT [] synonym: "2-aminobenzenesulfonate catabolism" EXACT [] synonym: "2-aminobenzenesulfonate degradation" EXACT [] synonym: "2-aminobenzenesulphonate catabolic process" EXACT [] synonym: "2-aminobenzenesulphonate catabolism" EXACT [] is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0046231 name: carbazole biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai] comment: This term was made obsolete because carbazole is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "carbazole anabolism" EXACT [] synonym: "carbazole biosynthesis" EXACT [] synonym: "carbazole formation" EXACT [] synonym: "carbazole synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018884 [Term] id: GO:0046232 name: carbazole catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai] subset: gosubset_prok synonym: "carbazole breakdown" EXACT [] synonym: "carbazole catabolism" EXACT [] synonym: "carbazole degradation" EXACT [] is_a: GO:0018884 ! carbazole metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046233 name: 3-hydroxyphenylacetate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] comment: This term was made obsolete because 3-hydroxyphenylacetate is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "3-hydroxyphenylacetate anabolism" EXACT [] synonym: "3-hydroxyphenylacetate biosynthesis" EXACT [] synonym: "3-hydroxyphenylacetate formation" EXACT [] synonym: "3-hydroxyphenylacetate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0019609 [Term] id: GO:0046234 name: fluorene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:ai] comment: This term was made obsolete because fluorene is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "fluorene anabolism" EXACT [] synonym: "fluorene biosynthesis" EXACT [] synonym: "fluorene formation" EXACT [] synonym: "fluorene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018917 [Term] id: GO:0046235 name: gallate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:ai] subset: gosubset_prok synonym: "gallate anabolism" EXACT [] synonym: "gallate biosynthesis" EXACT [] synonym: "gallate formation" EXACT [] synonym: "gallate synthesis" EXACT [] synonym: "gallic acid biosynthesis" EXACT [] synonym: "gallic acid biosynthetic process" EXACT [] is_a: GO:0009713 ! catechol biosynthetic process is_a: GO:0018918 ! gallate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0046236 name: mandelate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:ai] subset: gosubset_prok synonym: "mandelate anabolism" EXACT [] synonym: "mandelate biosynthesis" EXACT [] synonym: "mandelate formation" EXACT [] synonym: "mandelate synthesis" EXACT [] is_a: GO:0018924 ! mandelate metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process [Term] id: GO:0046237 name: phenanthrene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:ai] comment: This term was made obsolete because phenanthrene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "phenanthrene anabolism" EXACT [] synonym: "phenanthrene biosynthesis" EXACT [] synonym: "phenanthrene formation" EXACT [] synonym: "phenanthrene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018955 [Term] id: GO:0046238 name: phthalate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phthalate, any ester or salt of phthalic acid." [GOC:ai] comment: This term was made obsolete because phthalates are not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "phthalate anabolism" EXACT [] synonym: "phthalate biosynthesis" EXACT [] synonym: "phthalate formation" EXACT [] synonym: "phthalate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018963 [Term] id: GO:0046239 name: phthalate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid." [GOC:ai] subset: gosubset_prok synonym: "phthalate breakdown" EXACT [] synonym: "phthalate catabolism" EXACT [] synonym: "phthalate degradation" EXACT [] is_a: GO:0018963 ! phthalate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0046240 name: xylene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:ai] comment: This term was made obsolete because xylene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "xylene anabolism" EXACT [] synonym: "xylene biosynthesis" EXACT [] synonym: "xylene formation" EXACT [] synonym: "xylene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018948 [Term] id: GO:0046241 name: m-xylene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:ai] comment: This term was made obsolete because m-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "m-xylene anabolism" EXACT [] synonym: "m-xylene biosynthesis" EXACT [] synonym: "m-xylene formation" EXACT [] synonym: "m-xylene synthesis" EXACT [] synonym: "meta-xylene biosynthesis" EXACT [] synonym: "meta-xylene biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018949 [Term] id: GO:0046242 name: o-xylene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:ai] comment: This term was made obsolete because o-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "o-xylene anabolism" EXACT [] synonym: "o-xylene biosynthesis" EXACT [] synonym: "o-xylene formation" EXACT [] synonym: "o-xylene synthesis" EXACT [] synonym: "ortho-xylene biosynthesis" EXACT [] synonym: "ortho-xylene biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018950 [Term] id: GO:0046243 name: p-xylene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:ai] comment: This term was made obsolete because p-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "p-xylene anabolism" EXACT [] synonym: "p-xylene biosynthesis" EXACT [] synonym: "p-xylene formation" EXACT [] synonym: "p-xylene synthesis" EXACT [] synonym: "para-xylene biosynthesis" EXACT [] synonym: "para-xylene biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018951 [Term] id: GO:0046244 name: salicylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [GOC:ai] subset: gosubset_prok synonym: "salicylic acid breakdown" EXACT [] synonym: "salicylic acid catabolism" EXACT [] synonym: "salicylic acid degradation" EXACT [] is_a: GO:0009696 ! salicylic acid metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046245 name: styrene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:ai] comment: This term was made obsolete because styrene is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "styrene anabolism" EXACT [] synonym: "styrene biosynthesis" EXACT [] synonym: "styrene formation" EXACT [] synonym: "styrene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018966 [Term] id: GO:0046246 name: terpene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai] subset: gosubset_prok synonym: "terpene anabolism" EXACT [] synonym: "terpene biosynthesis" EXACT [] synonym: "terpene formation" EXACT [] synonym: "terpene synthesis" EXACT [] is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0046247 name: terpene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai] subset: gosubset_prok synonym: "terpene breakdown" EXACT [] synonym: "terpene catabolism" EXACT [] synonym: "terpene degradation" EXACT [] is_a: GO:0008300 ! isoprenoid catabolic process is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0046248 name: alpha-pinene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai] subset: gosubset_prok synonym: "alpha-pinene anabolism" EXACT [] synonym: "alpha-pinene biosynthesis" EXACT [] synonym: "alpha-pinene formation" EXACT [] synonym: "alpha-pinene synthesis" EXACT [] is_a: GO:0018867 ! alpha-pinene metabolic process is_a: GO:0043693 ! monoterpene biosynthetic process [Term] id: GO:0046249 name: alpha-pinene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai] subset: gosubset_prok synonym: "alpha-pinene breakdown" EXACT [] synonym: "alpha-pinene catabolism" EXACT [] synonym: "alpha-pinene degradation" EXACT [] is_a: GO:0018867 ! alpha-pinene metabolic process is_a: GO:0043694 ! monoterpene catabolic process [Term] id: GO:0046250 name: limonene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai] subset: gosubset_prok synonym: "limonene anabolism" EXACT [] synonym: "limonene biosynthesis" EXACT [] synonym: "limonene formation" EXACT [] synonym: "limonene synthesis" EXACT [] is_a: GO:0018923 ! limonene metabolic process is_a: GO:0043693 ! monoterpene biosynthetic process [Term] id: GO:0046251 name: limonene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai] subset: gosubset_prok synonym: "limonene breakdown" EXACT [] synonym: "limonene catabolism" EXACT [] synonym: "limonene degradation" EXACT [] is_a: GO:0018923 ! limonene metabolic process is_a: GO:0043694 ! monoterpene catabolic process [Term] id: GO:0046252 name: toluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:ai] comment: This term was made obsolete because toluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "toluene anabolism" EXACT [] synonym: "toluene biosynthesis" EXACT [] synonym: "toluene formation" EXACT [] synonym: "toluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018970 [Term] id: GO:0046253 name: anaerobic toluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai] comment: This term was made obsolete because toluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "anaerobic toluene anabolism" EXACT [] synonym: "anaerobic toluene biosynthesis" EXACT [] synonym: "anaerobic toluene formation" EXACT [] synonym: "anaerobic toluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018971 [Term] id: GO:0046254 name: anaerobic toluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic toluene breakdown" EXACT [] synonym: "anaerobic toluene catabolism" EXACT [] synonym: "anaerobic toluene degradation" EXACT [] xref: MetaCyc:PWY-81 is_a: GO:0042203 ! toluene catabolic process [Term] id: GO:0046255 name: 2,4,6-trinitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "2,4,6-trinitrotoluene anabolism" EXACT [] synonym: "2,4,6-trinitrotoluene biosynthesis" EXACT [] synonym: "2,4,6-trinitrotoluene formation" EXACT [] synonym: "2,4,6-trinitrotoluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018974 [Term] id: GO:0046256 name: 2,4,6-trinitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid." [GOC:ai] subset: gosubset_prok synonym: "2,4,6-trinitrotoluene breakdown" EXACT [] synonym: "2,4,6-trinitrotoluene catabolism" EXACT [] synonym: "2,4,6-trinitrotoluene degradation" EXACT [] is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process is_a: GO:0046260 ! trinitrotoluene catabolic process [Term] id: GO:0046257 name: anaerobic 2,4,6-trinitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai] comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "anaerobic 2,4,6-trinitrotoluene anabolism" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene biosynthesis" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene formation" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018975 [Term] id: GO:0046258 name: anaerobic 2,4,6-trinitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai] subset: gosubset_prok synonym: "anaerobic 2,4,6-trinitrotoluene breakdown" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene catabolism" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene degradation" EXACT [] is_a: GO:0018975 ! anaerobic 2,4,6-trinitrotoluene metabolic process is_a: GO:0046256 ! 2,4,6-trinitrotoluene catabolic process [Term] id: GO:0046259 name: trinitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it." [GOC:ai] comment: This term was made obsolete because trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "trinitrotoluene anabolism" EXACT [] synonym: "trinitrotoluene biosynthesis" EXACT [] synonym: "trinitrotoluene formation" EXACT [] synonym: "trinitrotoluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018973 [Term] id: GO:0046260 name: trinitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] subset: gosubset_prok synonym: "trinitrotoluene breakdown" EXACT [] synonym: "trinitrotoluene catabolism" EXACT [] synonym: "trinitrotoluene degradation" EXACT [] is_a: GO:0018973 ! trinitrotoluene metabolic process is_a: GO:0046263 ! nitrotoluene catabolic process [Term] id: GO:0046261 name: 4-nitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai] comment: This term was made obsolete because 4-nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "4-nitrotoluene anabolism" EXACT [] synonym: "4-nitrotoluene biosynthesis" EXACT [] synonym: "4-nitrotoluene formation" EXACT [] synonym: "4-nitrotoluene synthesis" EXACT [] synonym: "4NT biosynthesis" EXACT [] synonym: "4NT biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0019257 [Term] id: GO:0046262 name: nitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] comment: This term was made obsolete because nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "nitrotoluene anabolism" EXACT [] synonym: "nitrotoluene biosynthesis" EXACT [] synonym: "nitrotoluene formation" EXACT [] synonym: "nitrotoluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0019326 [Term] id: GO:0046263 name: nitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] subset: gosubset_prok synonym: "nitrotoluene breakdown" EXACT [] synonym: "nitrotoluene catabolism" EXACT [] synonym: "nitrotoluene degradation" EXACT [] is_a: GO:0019326 ! nitrotoluene metabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0046264 name: thiocyanate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of thiocyanate, any anion or salt of thiocyanic acid." [GOC:ai] comment: This term was made obsolete because thiocyanates are not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "thiocyanate anabolism" EXACT [] synonym: "thiocyanate biosynthesis" EXACT [] synonym: "thiocyanate formation" EXACT [] synonym: "thiocyanate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018969 [Term] id: GO:0046265 name: thiocyanate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid." [GOC:ai] subset: gosubset_prok synonym: "thiocyanate breakdown" EXACT [] synonym: "thiocyanate catabolism" EXACT [] synonym: "thiocyanate degradation" EXACT [] is_a: GO:0018969 ! thiocyanate metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0046266 name: triethanolamine biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai] comment: This term was made obsolete because triethanolamine is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "triethanolamine anabolism" EXACT [] synonym: "triethanolamine biosynthesis" EXACT [] synonym: "triethanolamine formation" EXACT [] synonym: "triethanolamine synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018981 [Term] id: GO:0046267 name: triethanolamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai] subset: gosubset_prok synonym: "triethanolamine breakdown" EXACT [] synonym: "triethanolamine catabolism" EXACT [] synonym: "triethanolamine degradation" EXACT [] is_a: GO:0009310 ! amine catabolic process is_a: GO:0018981 ! triethanolamine metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0046268 name: toluene-4-sulfonate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai] comment: This term was made obsolete because toluene-4-sulfonate is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "4-toluenesulfonate biosynthesis" EXACT [] synonym: "4-toluenesulfonate biosynthetic process" EXACT [] synonym: "toluene-4-sulfonate anabolism" EXACT [] synonym: "toluene-4-sulfonate biosynthesis" EXACT [] synonym: "toluene-4-sulfonate formation" EXACT [] synonym: "toluene-4-sulfonate synthesis" EXACT [] synonym: "toluene-4-sulphonate biosynthesis" EXACT [] synonym: "toluene-4-sulphonate biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018972 [Term] id: GO:0046269 name: toluene-4-sulfonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai] subset: gosubset_prok synonym: "4-toluenesulfonate catabolic process" EXACT [] synonym: "4-toluenesulfonate catabolism" EXACT [] synonym: "toluene-4-sulfonate breakdown" EXACT [] synonym: "toluene-4-sulfonate catabolism" EXACT [] synonym: "toluene-4-sulfonate degradation" EXACT [] synonym: "toluene-4-sulphonate catabolic process" EXACT [] synonym: "toluene-4-sulphonate catabolism" EXACT [] is_a: GO:0018972 ! toluene-4-sulfonate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0046270 name: 4-toluenecarboxylate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] comment: This term was made obsolete because 4-toluenecarboxylate is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "4-toluenecarboxylate anabolism" EXACT [] synonym: "4-toluenecarboxylate biosynthesis" EXACT [] synonym: "4-toluenecarboxylate formation" EXACT [] synonym: "4-toluenecarboxylate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0019611 [Term] id: GO:0046271 name: phenylpropanoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid." [GOC:ai] subset: gosubset_prok synonym: "phenylpropanoid breakdown" EXACT [] synonym: "phenylpropanoid catabolism" EXACT [] synonym: "phenylpropanoid degradation" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0019439 ! aromatic compound catabolic process [Term] id: GO:0046272 name: stilbene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:ai] subset: gosubset_prok synonym: "stilbene breakdown" EXACT [] synonym: "stilbene catabolism" EXACT [] synonym: "stilbene degradation" EXACT [] is_a: GO:0009810 ! stilbene metabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046273 name: lignan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] subset: gosubset_prok synonym: "lignan breakdown" EXACT [] synonym: "lignan catabolism" EXACT [] synonym: "lignan degradation" EXACT [] is_a: GO:0009806 ! lignan metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046274 name: lignin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units." [GOC:ai] subset: gosubset_prok synonym: "lignin breakdown" EXACT [] synonym: "lignin catabolism" EXACT [] synonym: "lignin degradation" EXACT [] is_a: GO:0009808 ! lignin metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046275 name: flavonoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:ai] subset: gosubset_prok synonym: "flavonoid breakdown" EXACT [] synonym: "flavonoid catabolism" EXACT [] synonym: "flavonoid degradation" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046276 name: methylgallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] subset: gosubset_prok synonym: "methylgallate breakdown" EXACT [] synonym: "methylgallate catabolism" EXACT [] synonym: "methylgallate degradation" EXACT [] xref: MetaCyc:METHYLGALLATE-DEGRADATION-PWY is_a: GO:0019396 ! gallate catabolic process is_a: GO:0019489 ! methylgallate metabolic process [Term] id: GO:0046277 name: methylgallate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] subset: gosubset_prok synonym: "methylgallate anabolism" EXACT [] synonym: "methylgallate biosynthesis" EXACT [] synonym: "methylgallate formation" EXACT [] synonym: "methylgallate synthesis" EXACT [] is_a: GO:0019489 ! methylgallate metabolic process is_a: GO:0046235 ! gallate biosynthetic process [Term] id: GO:0046278 name: protocatechuate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid)." [GOC:ai, http://chemfinder.cambridgesoft.com/] subset: gosubset_prok synonym: "3,4-dihydroxybenzoate metabolic process" EXACT [CHEBI:36241] synonym: "protocatechuate metabolism" EXACT [] is_a: GO:0009712 ! catechol metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0046279 name: protocatechuate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protocatechuate, the anion of 3,4-dihydroxybenzoic acid." [GOC:ai] subset: gosubset_prok synonym: "3,4-dihydroxybenzoate biosynthetic process" EXACT [CHEBI:36241] synonym: "protocatechuate anabolism" EXACT [] synonym: "protocatechuate biosynthesis" EXACT [] synonym: "protocatechuate formation" EXACT [] synonym: "protocatechuate synthesis" EXACT [] is_a: GO:0009713 ! catechol biosynthetic process is_a: GO:0046278 ! protocatechuate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0046280 name: chalcone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:ai] subset: gosubset_prok synonym: "chalcone breakdown" EXACT [] synonym: "chalcone catabolism" EXACT [] synonym: "chalcone degradation" EXACT [] is_a: GO:0009714 ! chalcone metabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046281 name: cinnamic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:ai] subset: gosubset_prok synonym: "cinnamic acid breakdown" EXACT [] synonym: "cinnamic acid catabolism" EXACT [] synonym: "cinnamic acid degradation" EXACT [] synonym: "cinnamylic acid catabolic process" EXACT [] synonym: "cinnamylic acid catabolism" EXACT [] synonym: "phenylacrylic acid catabolic process" EXACT [] synonym: "phenylacrylic acid catabolism" EXACT [] is_a: GO:0009803 ! cinnamic acid metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046282 name: cinnamic acid ester catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:ai] subset: gosubset_prok synonym: "cinnamic acid ester breakdown" EXACT [] synonym: "cinnamic acid ester catabolism" EXACT [] synonym: "cinnamic acid ester degradation" EXACT [] is_a: GO:0009801 ! cinnamic acid ester metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046283 name: anthocyanin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "anthocyanin metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0046284 name: anthocyanin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] subset: gosubset_prok synonym: "anthocyanin breakdown" EXACT [] synonym: "anthocyanin catabolism" EXACT [] synonym: "anthocyanin degradation" EXACT [] is_a: GO:0046149 ! pigment catabolic process is_a: GO:0046275 ! flavonoid catabolic process is_a: GO:0046283 ! anthocyanin metabolic process [Term] id: GO:0046285 name: flavonoid phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "flavonoid phytoalexin metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process [Term] id: GO:0046286 name: flavonoid phytoalexin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] subset: gosubset_prok synonym: "flavonoid phytoalexin breakdown" EXACT [] synonym: "flavonoid phytoalexin catabolism" EXACT [] synonym: "flavonoid phytoalexin degradation" EXACT [] is_a: GO:0046275 ! flavonoid catabolic process is_a: GO:0046285 ! flavonoid phytoalexin metabolic process is_a: GO:0052316 ! phytoalexin catabolic process [Term] id: GO:0046287 name: isoflavonoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring group." [CHEBI:50753, GOC:ai] subset: gosubset_prok synonym: "isoflavonoid metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046288 name: isoflavonoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] subset: gosubset_prok synonym: "isoflavonoid breakdown" EXACT [] synonym: "isoflavonoid catabolism" EXACT [] synonym: "isoflavonoid degradation" EXACT [] is_a: GO:0046271 ! phenylpropanoid catabolic process is_a: GO:0046287 ! isoflavonoid metabolic process [Term] id: GO:0046289 name: isoflavonoid phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] subset: gosubset_prok synonym: "isoflavonoid phytoalexin metabolism" EXACT [] is_a: GO:0046287 ! isoflavonoid metabolic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0046290 name: isoflavonoid phytoalexin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] subset: gosubset_prok synonym: "isoflavonoid phytoalexin breakdown" EXACT [] synonym: "isoflavonoid phytoalexin catabolism" EXACT [] synonym: "isoflavonoid phytoalexin degradation" EXACT [] is_a: GO:0046288 ! isoflavonoid catabolic process is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process is_a: GO:0052316 ! phytoalexin catabolic process [Term] id: GO:0046291 name: 6-hydroxycineole biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] comment: This term was made obsolete because 6-hydroxycineole is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "6-endo-hydroxycineole biosynthesis" EXACT [] synonym: "6-endo-hydroxycineole biosynthetic process" EXACT [] synonym: "6-hydroxycineole anabolism" EXACT [] synonym: "6-hydroxycineole biosynthesis" EXACT [] synonym: "6-hydroxycineole formation" EXACT [] synonym: "6-hydroxycineole synthesis" EXACT [] synonym: "hydroxycineol biosynthesis" EXACT [] synonym: "hydroxycineol biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0019638 [Term] id: GO:0046292 name: formaldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent." [CHEBI:16842, GOC:ai, http://chemfinder.cambridgesoft.com/] subset: gosubset_prok synonym: "formaldehyde metabolism" EXACT [] synonym: "methanal metabolic process" EXACT [] synonym: "methanal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0046293 name: formaldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] subset: gosubset_prok synonym: "formaldehyde anabolism" EXACT [] synonym: "formaldehyde biosynthesis" EXACT [] synonym: "formaldehyde formation" EXACT [] synonym: "formaldehyde synthesis" EXACT [] synonym: "methanal biosynthesis" EXACT [] synonym: "methanal biosynthetic process" EXACT [] is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0046292 ! formaldehyde metabolic process [Term] id: GO:0046294 name: formaldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] subset: gosubset_prok synonym: "formaldehyde breakdown" EXACT [] synonym: "formaldehyde catabolism" EXACT [] synonym: "formaldehyde degradation" EXACT [] synonym: "methanal catabolic process" EXACT [] synonym: "methanal catabolism" EXACT [] is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046292 ! formaldehyde metabolic process [Term] id: GO:0046295 name: glycolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai] subset: gosubset_prok synonym: "glycolate anabolism" EXACT [] synonym: "glycolate biosynthesis" EXACT [] synonym: "glycolate formation" EXACT [] synonym: "glycolate synthesis" EXACT [] is_a: GO:0009441 ! glycolate metabolic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0046296 name: glycolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai] subset: gosubset_prok synonym: "glycolate breakdown" EXACT [] synonym: "glycolate catabolism" EXACT [] synonym: "glycolate degradation" EXACT [] is_a: GO:0009441 ! glycolate metabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046297 name: 2,4-dichlorobenzoate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai] comment: This term was made obsolete because 2,4-dichlorobenzoate is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "2,4-dichlorobenzoate anabolism" EXACT [] synonym: "2,4-dichlorobenzoate biosynthesis" EXACT [] synonym: "2,4-dichlorobenzoate formation" EXACT [] synonym: "2,4-dichlorobenzoate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018898 [Term] id: GO:0046298 name: 2,4-dichlorobenzoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai] subset: gosubset_prok synonym: "2,4-dichlorobenzoate breakdown" EXACT [] synonym: "2,4-dichlorobenzoate catabolism" EXACT [] synonym: "2,4-dichlorobenzoate degradation" EXACT [] is_a: GO:0018898 ! 2,4-dichlorobenzoate metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process [Term] id: GO:0046299 name: 2,4-dichlorophenoxyacetic acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai] comment: This term was made obsolete because 2,4-dichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "2,4-dichlorophenoxyacetic acid anabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid biosynthesis" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid formation" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018901 [Term] id: GO:0046300 name: 2,4-dichlorophenoxyacetic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai] subset: gosubset_prok synonym: "2,4-dichlorophenoxyacetic acid breakdown" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid catabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid degradation" EXACT [] is_a: GO:0018901 ! 2,4-dichlorophenoxyacetic acid metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046301 name: 2-chloro-N-isopropylacetanilide biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai] comment: This term was made obsolete because 2-chloro-N-isopropylacetanilide is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "2-chloro-N-isopropylacetanilide anabolism" EXACT [] synonym: "2-chloro-N-isopropylacetanilide biosynthesis" EXACT [] synonym: "2-chloro-N-isopropylacetanilide formation" EXACT [] synonym: "2-chloro-N-isopropylacetanilide synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018889 [Term] id: GO:0046302 name: 2-chloro-N-isopropylacetanilide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai] subset: gosubset_prok synonym: "2-chloro-N-isopropylacetanilide breakdown" EXACT [] synonym: "2-chloro-N-isopropylacetanilide catabolism" EXACT [] synonym: "2-chloro-N-isopropylacetanilide degradation" EXACT [] is_a: GO:0018889 ! 2-chloro-N-isopropylacetanilide metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process [Term] id: GO:0046303 name: 2-nitropropane biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai] comment: This term was made obsolete because 2-nitropropane is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "2-nitropropane anabolism" EXACT [] synonym: "2-nitropropane biosynthesis" EXACT [] synonym: "2-nitropropane formation" EXACT [] synonym: "2-nitropropane synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018938 [Term] id: GO:0046304 name: 2-nitropropane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai] subset: gosubset_prok synonym: "2-nitropropane breakdown" EXACT [] synonym: "2-nitropropane catabolism" EXACT [] synonym: "2-nitropropane degradation" EXACT [] is_a: GO:0018938 ! 2-nitropropane metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043448 ! alkane catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0046305 name: alkanesulfonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] subset: gosubset_prok synonym: "alkanesulfonate anabolism" EXACT [] synonym: "alkanesulfonate biosynthesis" EXACT [] synonym: "alkanesulfonate formation" EXACT [] synonym: "alkanesulfonate synthesis" EXACT [] synonym: "alkanesulphonate biosynthesis" EXACT [] synonym: "alkanesulphonate biosynthetic process" EXACT [] is_a: GO:0019694 ! alkanesulfonate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0046306 name: alkanesulfonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] subset: gosubset_prok synonym: "alkanesulfonate breakdown" EXACT [] synonym: "alkanesulfonate catabolism" EXACT [] synonym: "alkanesulfonate degradation" EXACT [] synonym: "alkanesulphonate catabolic process" EXACT [] synonym: "alkanesulphonate catabolism" EXACT [] is_a: GO:0019694 ! alkanesulfonate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0046307 name: Z-phenylacetaldoxime biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai] subset: gosubset_prok synonym: "Z-phenylacetaldoxime anabolism" EXACT [] synonym: "Z-phenylacetaldoxime biosynthesis" EXACT [] synonym: "Z-phenylacetaldoxime formation" EXACT [] synonym: "Z-phenylacetaldoxime synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process [Term] id: GO:0046308 name: Z-phenylacetaldoxime catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai] subset: gosubset_prok synonym: "Z-phenylacetaldoxime breakdown" EXACT [] synonym: "Z-phenylacetaldoxime catabolism" EXACT [] synonym: "Z-phenylacetaldoxime degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process [Term] id: GO:0046309 name: 1,3-dichloro-2-propanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai] subset: gosubset_prok synonym: "1,3-dichloro-2-propanol anabolism" EXACT [] synonym: "1,3-dichloro-2-propanol biosynthesis" EXACT [] synonym: "1,3-dichloro-2-propanol formation" EXACT [] synonym: "1,3-dichloro-2-propanol synthesis" EXACT [] is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process is_a: GO:0044108 ! cellular alcohol biosynthetic process [Term] id: GO:0046310 name: 1,3-dichloro-2-propanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai] subset: gosubset_prok synonym: "1,3-dichloro-2-propanol breakdown" EXACT [] synonym: "1,3-dichloro-2-propanol catabolism" EXACT [] synonym: "1,3-dichloro-2-propanol degradation" EXACT [] is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process is_a: GO:0044109 ! cellular alcohol catabolic process [Term] id: GO:0046311 name: prenylcysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai] subset: gosubset_prok synonym: "prenylcysteine anabolism" EXACT [] synonym: "prenylcysteine biosynthesis" EXACT [] synonym: "prenylcysteine formation" EXACT [] synonym: "prenylcysteine synthesis" EXACT [] is_a: GO:0030329 ! prenylcysteine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0046312 name: phosphoarginine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai] subset: gosubset_prok synonym: "phosphoarginine anabolism" EXACT [] synonym: "phosphoarginine biosynthesis" EXACT [] synonym: "phosphoarginine formation" EXACT [] synonym: "phosphoarginine synthesis" EXACT [] is_a: GO:0006604 ! phosphoarginine metabolic process is_a: GO:0042396 ! phosphagen biosynthetic process [Term] id: GO:0046313 name: phosphoarginine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai] subset: gosubset_prok synonym: "phosphoarginine breakdown" EXACT [] synonym: "phosphoarginine catabolism" EXACT [] synonym: "phosphoarginine degradation" EXACT [] is_a: GO:0006604 ! phosphoarginine metabolic process is_a: GO:0042397 ! phosphagen catabolic process [Term] id: GO:0046314 name: phosphocreatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai] subset: gosubset_prok synonym: "phosphocreatine anabolism" EXACT [] synonym: "phosphocreatine biosynthesis" EXACT [] synonym: "phosphocreatine formation" EXACT [] synonym: "phosphocreatine synthesis" EXACT [] is_a: GO:0006603 ! phosphocreatine metabolic process is_a: GO:0042396 ! phosphagen biosynthetic process [Term] id: GO:0046315 name: phosphocreatine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai] subset: gosubset_prok synonym: "phosphocreatine breakdown" EXACT [] synonym: "phosphocreatine catabolism" EXACT [] synonym: "phosphocreatine degradation" EXACT [] is_a: GO:0006603 ! phosphocreatine metabolic process is_a: GO:0042397 ! phosphagen catabolic process [Term] id: GO:0046316 name: gluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.12, RHEA:19436] subset: gosubset_prok synonym: "ATP:D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.12] synonym: "gluconate kinase activity" EXACT [EC:2.7.1.12] synonym: "gluconokinase (phosphorylating)" EXACT [EC:2.7.1.12] xref: EC:2.7.1.12 xref: KEGG:R01737 xref: MetaCyc:GLUCONOKIN-RXN xref: RHEA:19436 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0046317 name: regulation of glucosylceramide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "regulation of glucosylceramide anabolism" EXACT [] synonym: "regulation of glucosylceramide biosynthesis" EXACT [] synonym: "regulation of glucosylceramide formation" EXACT [] synonym: "regulation of glucosylceramide synthesis" EXACT [] is_a: GO:2000303 ! regulation of ceramide biosynthetic process relationship: regulates GO:0006679 ! glucosylceramide biosynthetic process [Term] id: GO:0046318 name: negative regulation of glucosylceramide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "down regulation of glucosylceramide biosynthetic process" EXACT [] synonym: "down-regulation of glucosylceramide biosynthetic process" EXACT [] synonym: "downregulation of glucosylceramide biosynthetic process" EXACT [] synonym: "inhibition of glucosylceramide biosynthetic process" NARROW [] synonym: "negative regulation of glucosylceramide anabolism" EXACT [] synonym: "negative regulation of glucosylceramide biosynthesis" EXACT [] synonym: "negative regulation of glucosylceramide formation" EXACT [] synonym: "negative regulation of glucosylceramide synthesis" EXACT [] is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process is_a: GO:0090155 ! negative regulation of sphingolipid biosynthetic process relationship: negatively_regulates GO:0006679 ! glucosylceramide biosynthetic process [Term] id: GO:0046319 name: positive regulation of glucosylceramide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai] subset: gosubset_prok synonym: "activation of glucosylceramide biosynthetic process" NARROW [] synonym: "positive regulation of glucosylceramide anabolism" EXACT [] synonym: "positive regulation of glucosylceramide biosynthesis" EXACT [] synonym: "positive regulation of glucosylceramide formation" EXACT [] synonym: "positive regulation of glucosylceramide synthesis" EXACT [] synonym: "stimulation of glucosylceramide biosynthetic process" NARROW [] synonym: "up regulation of glucosylceramide biosynthetic process" EXACT [] synonym: "up-regulation of glucosylceramide biosynthetic process" EXACT [] synonym: "upregulation of glucosylceramide biosynthetic process" EXACT [] is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process is_a: GO:2000304 ! positive regulation of ceramide biosynthetic process relationship: positively_regulates GO:0006679 ! glucosylceramide biosynthetic process [Term] id: GO:0046320 name: regulation of fatty acid oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fatty acid oxidation." [GOC:ai] subset: gosubset_prok xref: Reactome:1253066 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1280002 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1298893 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1326572 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1352684 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1372900 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1393346 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1417393 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1450491 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1471004 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1483029 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1496798 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1514188 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1521024 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1526761 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1532492 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:1536021 "Activated AMPK stimulates fatty-acid oxidation in muscle" xref: Reactome:200409 "Activated AMPK stimulates fatty-acid oxidation in muscle" is_a: GO:0019217 ! regulation of fatty acid metabolic process relationship: regulates GO:0019395 ! fatty acid oxidation [Term] id: GO:0046321 name: positive regulation of fatty acid oxidation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fatty acid oxidation." [GOC:ai] subset: gosubset_prok synonym: "activation of fatty acid oxidation" NARROW [] synonym: "stimulation of fatty acid oxidation" NARROW [] synonym: "up regulation of fatty acid oxidation" EXACT [] synonym: "up-regulation of fatty acid oxidation" EXACT [] synonym: "upregulation of fatty acid oxidation" EXACT [] is_a: GO:0045923 ! positive regulation of fatty acid metabolic process is_a: GO:0046320 ! regulation of fatty acid oxidation relationship: positively_regulates GO:0019395 ! fatty acid oxidation [Term] id: GO:0046322 name: negative regulation of fatty acid oxidation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation." [GOC:ai] subset: gosubset_prok synonym: "down regulation of fatty acid oxidation" EXACT [] synonym: "down-regulation of fatty acid oxidation" EXACT [] synonym: "downregulation of fatty acid oxidation" EXACT [] synonym: "inhibition of fatty acid oxidation" NARROW [] is_a: GO:0045922 ! negative regulation of fatty acid metabolic process is_a: GO:0046320 ! regulation of fatty acid oxidation relationship: negatively_regulates GO:0019395 ! fatty acid oxidation [Term] id: GO:0046323 name: glucose import namespace: biological_process def: "The directed movement of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] subset: gosubset_prok synonym: "glucose uptake" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Glucose_uptake is_a: GO:0015758 ! glucose transport [Term] id: GO:0046324 name: regulation of glucose import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] subset: gosubset_prok synonym: "regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0010827 ! regulation of glucose transport relationship: regulates GO:0046323 ! glucose import [Term] id: GO:0046325 name: negative regulation of glucose import namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] synonym: "down regulation of glucose import" EXACT [] synonym: "down-regulation of glucose import" EXACT [] synonym: "downregulation of glucose import" EXACT [] synonym: "inhibition of glucose import" NARROW [] synonym: "negative regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0010829 ! negative regulation of glucose transport is_a: GO:0046324 ! regulation of glucose import relationship: negatively_regulates GO:0046323 ! glucose import [Term] id: GO:0046326 name: positive regulation of glucose import namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "activation of glucose import" NARROW [] synonym: "positive regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of glucose import" NARROW [] synonym: "up regulation of glucose import" EXACT [] synonym: "up-regulation of glucose import" EXACT [] synonym: "upregulation of glucose import" EXACT [] is_a: GO:0010828 ! positive regulation of glucose transport is_a: GO:0046324 ! regulation of glucose import relationship: positively_regulates GO:0046323 ! glucose import [Term] id: GO:0046327 name: glycerol biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate." [GOC:ai] subset: gosubset_prok synonym: "glycerol anabolism from pyruvate" EXACT [] synonym: "glycerol formation from pyruvate" EXACT [] synonym: "glycerol synthesis from pyruvate" EXACT [] synonym: "glyceroneogenesis" EXACT [] is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0006114 ! glycerol biosynthetic process relationship: part_of GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0046328 name: regulation of JNK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] synonym: "regulation of SAPK cascade" BROAD [] is_a: GO:0043408 ! regulation of MAPKKK cascade is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade relationship: regulates GO:0007254 ! JNK cascade [Term] id: GO:0046329 name: negative regulation of JNK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] synonym: "down regulation of JNK cascade" EXACT [] synonym: "down-regulation of JNK cascade" EXACT [] synonym: "downregulation of JNK cascade" EXACT [] synonym: "inhibition of JNK cascade" NARROW [] is_a: GO:0043409 ! negative regulation of MAPKKK cascade is_a: GO:0046328 ! regulation of JNK cascade is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling cascade relationship: negatively_regulates GO:0007254 ! JNK cascade [Term] id: GO:0046330 name: positive regulation of JNK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] synonym: "activation of JNK cascade" NARROW [] synonym: "stimulation of JNK cascade" NARROW [] synonym: "up regulation of JNK cascade" EXACT [] synonym: "up-regulation of JNK cascade" EXACT [] synonym: "upregulation of JNK cascade" EXACT [] is_a: GO:0043410 ! positive regulation of MAPKKK cascade is_a: GO:0046328 ! regulation of JNK cascade is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling cascade relationship: positively_regulates GO:0007254 ! JNK cascade [Term] id: GO:0046331 name: lateral inhibition namespace: biological_process def: "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment [Term] id: GO:0046332 name: SMAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SMAD signaling protein." [GOC:ai] is_a: GO:0005515 ! protein binding [Term] id: GO:0046333 name: octopamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "octopamine metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0042439 ! ethanolamine-containing compound metabolic process [Term] id: GO:0046334 name: octopamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "octopamine breakdown" EXACT [] synonym: "octopamine catabolism" EXACT [] synonym: "octopamine degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0046333 ! octopamine metabolic process [Term] id: GO:0046335 name: ethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai] subset: gosubset_prok synonym: "ethanolamine anabolism" EXACT [] synonym: "ethanolamine biosynthesis" EXACT [] synonym: "ethanolamine formation" EXACT [] synonym: "ethanolamine synthesis" EXACT [] is_a: GO:0006580 ! ethanolamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0046336 name: ethanolamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai] subset: gosubset_prok synonym: "ethanolamine breakdown" EXACT [] synonym: "ethanolamine catabolism" EXACT [] synonym: "ethanolamine degradation" EXACT [] is_a: GO:0006580 ! ethanolamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0046337 name: phosphatidylethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [CHEBI:16038, GOC:curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylethanolamine metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0042439 ! ethanolamine-containing compound metabolic process [Term] id: GO:0046338 name: phosphatidylethanolamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylethanolamine breakdown" EXACT [] synonym: "phosphatidylethanolamine catabolism" EXACT [] synonym: "phosphatidylethanolamine degradation" EXACT [] is_a: GO:0046336 ! ethanolamine catabolic process is_a: GO:0046337 ! phosphatidylethanolamine metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0046339 name: diacylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. DAG is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase C activity. DAG from phosphatidyl inositol polyphosphates is important in signal transduction." [CHEBI:18035, GOC:curators] subset: gosubset_prok synonym: "diacylglycerol metabolism" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process [Term] id: GO:0046340 name: diacylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues." [CHEBI:18035, GOC:curators] subset: gosubset_prok synonym: "diacylglycerol breakdown" EXACT [] synonym: "diacylglycerol catabolism" EXACT [] synonym: "diacylglycerol degradation" EXACT [] is_a: GO:0046339 ! diacylglycerol metabolic process is_a: GO:0046464 ! acylglycerol catabolic process [Term] id: GO:0046341 name: CDP-diacylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis." [CHEBI:17962, GOC:curators] subset: gosubset_prok synonym: "CDP-diacylglycerol metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0046339 ! diacylglycerol metabolic process [Term] id: GO:0046342 name: CDP-diacylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [CHEBI:17962, GOC:curators] subset: gosubset_prok synonym: "CDP-diacylglycerol breakdown" EXACT [] synonym: "CDP-diacylglycerol catabolism" EXACT [] synonym: "CDP-diacylglycerol degradation" EXACT [] is_a: GO:0046340 ! diacylglycerol catabolic process is_a: GO:0046341 ! CDP-diacylglycerol metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0046343 name: streptomycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [CHEBI:17076, GOC:curators] subset: gosubset_prok synonym: "streptomycin metabolism" EXACT [] is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process [Term] id: GO:0046344 name: ecdysteroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai] synonym: "ecdysteroid breakdown" EXACT [] synonym: "ecdysteroid catabolism" EXACT [] synonym: "ecdysteroid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0046345 name: abscisic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [GOC:ai] subset: gosubset_prok synonym: "abscisic acid breakdown" EXACT [] synonym: "abscisic acid catabolism" EXACT [] synonym: "abscisic acid degradation" EXACT [] is_a: GO:0009687 ! abscisic acid metabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0043290 ! apocarotenoid catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046346 name: mannosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [CHEBI:25166, GOC:curators] subset: gosubset_prok synonym: "mannosamine breakdown" EXACT [] synonym: "mannosamine catabolism" EXACT [] synonym: "mannosamine degradation" EXACT [] is_a: GO:0006050 ! mannosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0046347 name: mannosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [CHEBI:25166, GOC:curators] subset: gosubset_prok synonym: "mannosamine anabolism" EXACT [] synonym: "mannosamine biosynthesis" EXACT [] synonym: "mannosamine formation" EXACT [] synonym: "mannosamine synthesis" EXACT [] is_a: GO:0006050 ! mannosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0046348 name: amino sugar catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [CHEBI:28963, GOC:curators] subset: gosubset_prok synonym: "amino sugar breakdown" EXACT [] synonym: "amino sugar catabolism" EXACT [] synonym: "amino sugar degradation" EXACT [] synonym: "aminosaccharide catabolic process" EXACT [] synonym: "aminosaccharide catabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0046365 ! monosaccharide catabolic process [Term] id: GO:0046349 name: amino sugar biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [CHEBI:28963, GOC:curators] subset: gosubset_prok synonym: "amino sugar anabolism" EXACT [] synonym: "amino sugar biosynthesis" EXACT [] synonym: "amino sugar formation" EXACT [] synonym: "amino sugar synthesis" EXACT [] synonym: "aminosaccharide biosynthesis" EXACT [] synonym: "aminosaccharide biosynthetic process" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process [Term] id: GO:0046350 name: galactosaminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] subset: gosubset_prok synonym: "galactosaminoglycan metabolism" EXACT [] is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0046351 name: disaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units." [GOC:ai] subset: gosubset_prok synonym: "disaccharide anabolism" EXACT [] synonym: "disaccharide biosynthesis" EXACT [] synonym: "disaccharide formation" EXACT [] synonym: "disaccharide synthesis" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0009312 ! oligosaccharide biosynthetic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process [Term] id: GO:0046352 name: disaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units." [GOC:ai] subset: gosubset_prok synonym: "disaccharide breakdown" EXACT [] synonym: "disaccharide catabolism" EXACT [] synonym: "disaccharide degradation" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0046353 name: aminoglycoside 3-N-acetyltransferase activity namespace: molecular_function alt_id: GO:0016991 def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring." [GOC:cb] subset: gosubset_prok synonym: "3'-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81] synonym: "3-N-aminoglycoside acetyltransferase activity" EXACT [EC:2.3.1.81] synonym: "acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity" EXACT [EC:2.3.1.81] synonym: "acetyl-CoA:gentamicin-C N3'-acetyltransferase activity" NARROW [EC:2.3.1.60] synonym: "aminoglycoside acetyltransferase AAC(3)-1" RELATED [EC:2.3.1.60] synonym: "aminoglycoside acetyltransferase AAC(3)-I activity" RELATED [EC:2.3.1.60] synonym: "gentamicin 3'-N-acetyltransferase activity" NARROW [] synonym: "gentamicin acetyltransferase I activity" NARROW [EC:2.3.1.60] synonym: "gentamicin-(3)-N-acetyltransferase activity" NARROW [EC:2.3.1.81] synonym: "gentamycin 3'-N-acetyltransferase activity" EXACT [] synonym: "gentamycin acetyltransferase I" RELATED [EC:2.3.1.60] xref: EC:2.3.1.60 xref: EC:2.3.1.81 xref: MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN xref: MetaCyc:GENTAMICIN-3-N-ACETYLTRANSFERASE-RXN is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity [Term] id: GO:0046354 name: mannan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannan anabolism" EXACT [] synonym: "mannan biosynthesis" EXACT [] synonym: "mannan formation" EXACT [] synonym: "mannan synthesis" EXACT [] is_a: GO:0010412 ! mannan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0046355 name: mannan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannan breakdown" EXACT [] synonym: "mannan catabolism" EXACT [] synonym: "mannan degradation" EXACT [] is_a: GO:0010412 ! mannan metabolic process is_a: GO:0044039 ! cellular cell wall macromolecule catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0046356 name: acetyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:ai] subset: gosubset_prok synonym: "acetyl-CoA breakdown" EXACT [] synonym: "acetyl-CoA catabolism" EXACT [] synonym: "acetyl-CoA degradation" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0009109 ! coenzyme catabolic process [Term] id: GO:0046357 name: galactarate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactarate anabolism" EXACT [] synonym: "galactarate biosynthesis" EXACT [] synonym: "galactarate formation" EXACT [] synonym: "galactarate synthesis" EXACT [] is_a: GO:0019578 ! aldaric acid biosynthetic process is_a: GO:0019580 ! galactarate metabolic process [Term] id: GO:0046358 name: butyrate biosynthetic process namespace: biological_process alt_id: GO:0043439 def: "The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "butanoic acid anabolism" EXACT [] synonym: "butanoic acid biosynthesis" EXACT [] synonym: "butanoic acid biosynthetic process" EXACT [] synonym: "butanoic acid formation" EXACT [] synonym: "butanoic acid synthesis" EXACT [] synonym: "butyrate anabolism" EXACT [] synonym: "butyrate biosynthesis" EXACT [] synonym: "butyrate formation" EXACT [] synonym: "butyrate synthesis" EXACT [] is_a: GO:0019605 ! butyrate metabolic process is_a: GO:0051790 ! short-chain fatty acid biosynthetic process [Term] id: GO:0046359 name: butyrate catabolic process namespace: biological_process alt_id: GO:0043440 def: "The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "butanoic acid breakdown" EXACT [] synonym: "butanoic acid catabolic process" EXACT [] synonym: "butanoic acid catabolism" EXACT [] synonym: "butanoic acid degradation" EXACT [] synonym: "butyrate breakdown" EXACT [] synonym: "butyrate catabolism" EXACT [] synonym: "butyrate degradation" EXACT [] is_a: GO:0019605 ! butyrate metabolic process is_a: GO:0019626 ! short-chain fatty acid catabolic process [Term] id: GO:0046360 name: 2-oxobutyrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "2-oxobutyrate anabolism" EXACT [] synonym: "2-oxobutyrate biosynthesis" EXACT [] synonym: "2-oxobutyrate formation" EXACT [] synonym: "2-oxobutyrate synthesis" EXACT [] synonym: "alpha-ketobutyrate biosynthesis" EXACT [] synonym: "alpha-ketobutyrate biosynthetic process" EXACT [] is_a: GO:0046358 ! butyrate biosynthetic process is_a: GO:0046361 ! 2-oxobutyrate metabolic process [Term] id: GO:0046361 name: 2-oxobutyrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [http://chemfinder.cambridgesoft.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "2-oxobutyrate metabolism" EXACT [] synonym: "alpha-ketobutyrate metabolic process" EXACT [] synonym: "alpha-ketobutyrate metabolism" EXACT [] is_a: GO:0019605 ! butyrate metabolic process [Term] id: GO:0046362 name: ribitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribitol anabolism" EXACT [] synonym: "ribitol biosynthesis" EXACT [] synonym: "ribitol formation" EXACT [] synonym: "ribitol synthesis" EXACT [] is_a: GO:0019322 ! pentose biosynthetic process is_a: GO:0019349 ! ribitol metabolic process is_a: GO:0019526 ! pentitol biosynthetic process [Term] id: GO:0046363 name: ribitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribitol breakdown" EXACT [] synonym: "ribitol catabolism" EXACT [] synonym: "ribitol degradation" EXACT [] is_a: GO:0019323 ! pentose catabolic process is_a: GO:0019349 ! ribitol metabolic process is_a: GO:0019527 ! pentitol catabolic process [Term] id: GO:0046364 name: monosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "monosaccharide anabolism" EXACT [] synonym: "monosaccharide biosynthesis" EXACT [] synonym: "monosaccharide formation" EXACT [] synonym: "monosaccharide synthesis" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0046365 name: monosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "monosaccharide breakdown" EXACT [] synonym: "monosaccharide catabolism" EXACT [] synonym: "monosaccharide degradation" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0046366 name: allose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "allose anabolism" EXACT [] synonym: "allose biosynthesis" EXACT [] synonym: "allose formation" EXACT [] synonym: "allose synthesis" EXACT [] is_a: GO:0019313 ! allose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0046367 name: allose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "allose breakdown" EXACT [] synonym: "allose catabolism" EXACT [] synonym: "allose degradation" EXACT [] is_a: GO:0019313 ! allose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0046368 name: GDP-L-fucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "GDP-L-fucose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0042354 ! L-fucose metabolic process [Term] id: GO:0046369 name: galactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactose anabolism" EXACT [] synonym: "galactose biosynthesis" EXACT [] synonym: "galactose formation" EXACT [] synonym: "galactose synthesis" EXACT [] is_a: GO:0006012 ! galactose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0046370 name: fructose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] subset: gosubset_prok synonym: "fructose anabolism" EXACT [] synonym: "fructose biosynthesis" EXACT [] synonym: "fructose formation" EXACT [] synonym: "fructose synthesis" EXACT [] is_a: GO:0006000 ! fructose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0046371 name: dTDP-mannose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "dTDP-mannose metabolism" EXACT [] is_a: GO:0006013 ! mannose metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0046372 name: D-arabinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-arabinose, the D-enantiomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides." [CHEBI:17108, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-arabinose metabolism" EXACT [] is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0046373 name: L-arabinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-arabinose, the D-enantiomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc." [CHEBI:30849, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-arabinose metabolism" EXACT [] is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0046374 name: teichoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "teichoic acid metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0046375 name: K antigen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "K antigen metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0046376 name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolism" EXACT [] is_a: GO:0019348 ! dolichol metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0046377 name: colanic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues." [GOC:ai, http://www.science.siu.edu/microbiology/micr425/425Notes/02-CellEnv.html] subset: gosubset_prok synonym: "colanic acid metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0046378 name: enterobacterial common antigen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] subset: gosubset_prok synonym: "enterobacterial common antigen metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0046379 name: extracellular polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polysaccharides used in extracellular structures." [GOC:ai] subset: gosubset_prok synonym: "extracellular polysaccharide metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0046380 name: N-acetylneuraminate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylneuraminate anabolism" EXACT [] synonym: "N-acetylneuraminate biosynthesis" EXACT [] synonym: "N-acetylneuraminate formation" EXACT [] synonym: "N-acetylneuraminate synthesis" EXACT [] is_a: GO:0006054 ! N-acetylneuraminate metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0046381 name: CMP-N-acetylneuraminate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] subset: gosubset_prok synonym: "CMP-N-acetylneuraminate metabolism" EXACT [] is_a: GO:0006054 ! N-acetylneuraminate metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0046382 name: GDP-D-rhamnose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "GDP-D-rhamnose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0046383 name: dTDP-rhamnose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "dTDP-rhamnose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0046384 name: 2-deoxyribose 1-phosphate metabolic process namespace: biological_process alt_id: GO:0046388 def: "The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "2-deoxyribose 1-phosphate metabolism" EXACT [] synonym: "deoxyribose 1-phosphate metabolic process" EXACT [] synonym: "deoxyribose 1-phosphate metabolism" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process [Term] id: GO:0046385 name: deoxyribose phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribose phosphate anabolism" EXACT [] synonym: "deoxyribose phosphate biosynthesis" EXACT [] synonym: "deoxyribose phosphate formation" EXACT [] synonym: "deoxyribose phosphate synthesis" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0046386 name: deoxyribose phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribose phosphate breakdown" EXACT [] synonym: "deoxyribose phosphate catabolism" EXACT [] synonym: "deoxyribose phosphate degradation" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0046387 name: deoxyribose 1,5-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] subset: gosubset_prok synonym: "deoxyribose 1,5-bisphosphate metabolism" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process [Term] id: GO:0046389 name: deoxyribose 5-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose." [GOC:ai] subset: gosubset_prok synonym: "deoxyribose 5-phosphate metabolism" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process [Term] id: GO:0046390 name: ribose phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] subset: gosubset_prok synonym: "ribose phosphate anabolism" EXACT [] synonym: "ribose phosphate biosynthesis" EXACT [] synonym: "ribose phosphate formation" EXACT [] synonym: "ribose phosphate synthesis" EXACT [] is_a: GO:0019302 ! D-ribose biosynthetic process is_a: GO:0019693 ! ribose phosphate metabolic process [Term] id: GO:0046391 name: 5-phosphoribose 1-diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] subset: gosubset_prok synonym: "5-phosphoribose 1-diphosphate metabolism" EXACT [] synonym: "PRPP metabolic process" EXACT [] xref: MetaCyc:PRPP-PWY is_a: GO:0019693 ! ribose phosphate metabolic process [Term] id: GO:0046392 name: galactarate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid." [GOC:ai] subset: gosubset_prok synonym: "galactarate breakdown" EXACT [] synonym: "galactarate catabolism" EXACT [] synonym: "galactarate degradation" EXACT [] is_a: GO:0019579 ! aldaric acid catabolic process is_a: GO:0019580 ! galactarate metabolic process [Term] id: GO:0046393 name: D-galactarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-galactarate, the D-enantiomer of galactarate, the anion of galactaric acid." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-galactarate metabolism" EXACT [] is_a: GO:0019580 ! galactarate metabolic process [Term] id: GO:0046394 name: carboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "carboxylic acid anabolism" EXACT [] synonym: "carboxylic acid biosynthesis" EXACT [] synonym: "carboxylic acid formation" EXACT [] synonym: "carboxylic acid synthesis" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046395 name: carboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "carboxylic acid breakdown" EXACT [] synonym: "carboxylic acid catabolism" EXACT [] synonym: "carboxylic acid degradation" EXACT [] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046396 name: D-galacturonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls." [GOC:ai, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-galacturonate metabolism" EXACT [] is_a: GO:0019586 ! galacturonate metabolic process [Term] id: GO:0046397 name: galacturonate catabolic process namespace: biological_process alt_id: GO:0019587 def: "The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid." [GOC:ai] subset: gosubset_prok synonym: "galacturonate breakdown" EXACT [] synonym: "galacturonate catabolism" EXACT [] synonym: "galacturonate degradation" EXACT [] is_a: GO:0019586 ! galacturonate metabolic process is_a: GO:0046365 ! monosaccharide catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0046398 name: UDP-glucuronate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-glucuronate metabolism" EXACT [] is_a: GO:0019585 ! glucuronate metabolic process [Term] id: GO:0046399 name: glucuronate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid." [GOC:ai] subset: gosubset_prok synonym: "glucuronate anabolism" EXACT [] synonym: "glucuronate biosynthesis" EXACT [] synonym: "glucuronate formation" EXACT [] synonym: "glucuronate synthesis" EXACT [] is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0019585 ! glucuronate metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0046400 name: keto-3-deoxy-D-manno-octulosonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [CHEBI:32817, GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "KDO metabolic process" EXACT [GOC:mah] synonym: "KDO metabolism" EXACT [GOC:mah] synonym: "keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT [] synonym: "ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046401 name: lipopolysaccharide core region metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipopolysaccharide core region metabolism" EXACT [] synonym: "LPS core region metabolic process" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process relationship: part_of GO:0008653 ! lipopolysaccharide metabolic process [Term] id: GO:0046402 name: O antigen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "O antigen metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0046403 name: polynucleotide 3'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage." [EC:3.1.3.32] synonym: "2'(3')-polynucleotidase activity" EXACT [EC:3.1.3.32] synonym: "5'-polynucleotidekinase 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "deoxyribonucleate 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "DNA 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "polynucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.32] xref: EC:3.1.3.32 xref: MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN is_a: GO:0019204 ! nucleotide phosphatase activity [Term] id: GO:0046404 name: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA." [EC:2.7.1.78] synonym: "ATP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP-dependent DNA kinase activity" EXACT [] synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] xref: EC:2.7.1.78 xref: KEGG:R03840 xref: MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity [Term] id: GO:0046405 name: glycerol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O." [EC:4.2.1.30, PMID:18307109] subset: gosubset_prok synonym: "glycerol dehydrase activity" EXACT [EC:4.2.1.30] synonym: "glycerol hydro-lyase (3-hydroxypropanal-forming)" EXACT [EC:4.2.1.30] synonym: "glycerol hydro-lyase activity" EXACT [EC:4.2.1.30] xref: EC:4.2.1.30 xref: MetaCyc:GLYCEROL-DEHYDRATASE-RXN is_a: GO:0016836 ! hydro-lyase activity is_a: GO:0070283 ! radical SAM enzyme activity [Term] id: GO:0046406 name: magnesium protoporphyrin IX methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H(+) + magnesium protoporphyrin IX 13-monomethyl ester." [EC:2.1.1.11, RHEA:17812] subset: gosubset_prok synonym: "(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "magnesium-protoporphyrin O-methyltransferase activity" EXACT [] synonym: "Mg-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] xref: EC:2.1.1.11 xref: KEGG:R04237 xref: MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN xref: RHEA:17812 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0046408 name: chlorophyll synthetase activity namespace: molecular_function alt_id: GO:0043787 def: "Catalysis of the reaction: chlorophyllide a + 2 H(+) + phytyl diphosphate = chlorophyll a + diphosphate." [EC:2.5.1.62, RHEA:17320] synonym: "chlorophyll synthase activity" EXACT [] synonym: "chlorophyllide-a:phytyl-diphosphate phytyltransferase activity" EXACT [] xref: EC:2.5.1.62 xref: KEGG:R06284 xref: MetaCyc:RXN1F-66 xref: RHEA:17320 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0046409 name: p-coumarate 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+." [PMID:11429408, PMID:11891223] synonym: "cytochrome P450 CYP98A3" NARROW [] is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0046410 name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2." [EC:2.5.1.64, PMID:1459959] comment: This term was made obsolete because it was derived from an EC entry (2.5.1.64) that has since been split into two entries. is_obsolete: true consider: GO:0070204 consider: GO:0070205 [Term] id: GO:0046411 name: 2-keto-3-deoxygluconate transport namespace: biological_process def: "The directed movement of 2-keto-3-deoxygluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore by means of some agent such as a transporter or pore." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0046412 name: phenylmercury acetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai] subset: gosubset_prok synonym: "phenylmercury acetate metabolism" EXACT [] is_a: GO:0018941 ! organomercury metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0046413 name: organomercury catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai] subset: gosubset_prok synonym: "organomercury breakdown" EXACT [] synonym: "organomercury catabolism" EXACT [] synonym: "organomercury degradation" EXACT [] is_a: GO:0018941 ! organomercury metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0046414 name: organomercury biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai] subset: gosubset_prok synonym: "organomercury anabolism" EXACT [] synonym: "organomercury biosynthesis" EXACT [] synonym: "organomercury formation" EXACT [] synonym: "organomercury synthesis" EXACT [] is_a: GO:0018941 ! organomercury metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0046415 name: urate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "urate metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046416 name: D-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "D-amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0046417 name: chorismate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chorismate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0046418 name: nopaline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:ai] subset: gosubset_prok synonym: "nopaline metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0046419 name: octopine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:ai] subset: gosubset_prok synonym: "octopine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0046421 name: methylisocitrate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate." [EC:4.1.3.30, RHEA:16812] subset: gosubset_prok synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)" EXACT [EC:4.1.3.30] synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity" EXACT [EC:4.1.3.30] synonym: "2-methylisocitrate lyase activity" EXACT [] synonym: "MICL" RELATED [EC:4.1.3.30] xref: EC:4.1.3.30 xref: KEGG:R00409 xref: MetaCyc:METHYLISOCITRATE-LYASE-RXN xref: RHEA:16812 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0046422 name: violaxanthin de-epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O." [EC:1.10.99.3, GOC:ai, ISBN:0471331309 "Biochemical Pathways"] synonym: "VDE" RELATED [EC:1.10.99.3] synonym: "violaxanthin:ascorbate oxidoreductase activity" EXACT [EC:1.10.99.3] xref: EC:1.10.99.3 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0046423 name: allene-oxide cyclase activity namespace: molecular_function def: "Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate." [EC:5.3.99.6, RHEA:22595] synonym: "(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)" EXACT [EC:5.3.99.6] xref: EC:5.3.99.6 xref: KEGG:R03402 xref: MetaCyc:ALLENE-OXIDE-CYCLASE-RXN xref: RHEA:22595 is_a: GO:0009975 ! cyclase activity is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0046424 name: ferulate 5-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+." [PMID:8692910, PMID:9880351] xref: MetaCyc:RXN-1121 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0046425 name: regulation of JAK-STAT cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf] is_a: GO:0010627 ! regulation of intracellular protein kinase cascade relationship: regulates GO:0007259 ! JAK-STAT cascade [Term] id: GO:0046426 name: negative regulation of JAK-STAT cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] synonym: "down regulation of JAK-STAT cascade" EXACT [] synonym: "down-regulation of JAK-STAT cascade" EXACT [] synonym: "downregulation of JAK-STAT cascade" EXACT [] synonym: "inhibition of JAK-STAT cascade" NARROW [] is_a: GO:0010741 ! negative regulation of intracellular protein kinase cascade is_a: GO:0046425 ! regulation of JAK-STAT cascade relationship: negatively_regulates GO:0007259 ! JAK-STAT cascade [Term] id: GO:0046427 name: positive regulation of JAK-STAT cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] synonym: "activation of JAK-STAT cascade" NARROW [] synonym: "stimulation of JAK-STAT cascade" NARROW [] synonym: "up regulation of JAK-STAT cascade" EXACT [] synonym: "up-regulation of JAK-STAT cascade" EXACT [] synonym: "upregulation of JAK-STAT cascade" EXACT [] is_a: GO:0010740 ! positive regulation of intracellular protein kinase cascade is_a: GO:0046425 ! regulation of JAK-STAT cascade relationship: positively_regulates GO:0007259 ! JAK-STAT cascade [Term] id: GO:0046428 name: 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2." [MetaCyc:DMK-RXN] synonym: "1,4-Dihydroxy-2-naphtoate prenyltransferase activity" EXACT [] xref: EC:2.5.1.- xref: MetaCyc:DMK-RXN is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0046429 name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin." [EC:1.17.7.1, PMID:11752431] subset: gosubset_prok synonym: "(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity" EXACT systematic_synonym [EC:1.17.7.1] synonym: "(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity" EXACT [EC:1.17.7.1] synonym: "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity" EXACT [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP] synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" EXACT [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP] synonym: "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity" EXACT [EC:1.17.7.1] xref: EC:1.17.7.1 xref: KEGG:R08689 xref: MetaCyc:RXN0-882 is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor [Term] id: GO:0046430 name: non-phosphorylated glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving non-phosphorylated forms of glucose." [GOC:ai] subset: gosubset_prok synonym: "non-phosphorylated glucose metabolism" EXACT [] is_a: GO:0006006 ! glucose metabolic process [Term] id: GO:0046431 name: (R)-4-hydroxymandelate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "(R)-4-hydroxymandelate metabolism" EXACT [] is_a: GO:0018924 ! mandelate metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0046432 name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] subset: gosubset_prok synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0046433 name: 2-aminoethylphosphonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms." [GOC:ai, PMID:12107130] subset: gosubset_prok synonym: "2-aminoethylphosphonate metabolism" EXACT [] synonym: "2-phosphonoethylamine metabolic process" EXACT [] synonym: "2-phosphonoethylamine metabolism" EXACT [] synonym: "ciliatine metabolic process" EXACT [] synonym: "ciliatine metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0033051 ! aminophosphonate metabolic process [Term] id: GO:0046434 name: organophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai] subset: gosubset_prok synonym: "organophosphate breakdown" EXACT [] synonym: "organophosphate catabolism" EXACT [] synonym: "organophosphate degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0046435 name: 3-(3-hydroxy)phenylpropionate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai] subset: gosubset_prok synonym: "3-(3-hydroxy)phenylpropionate metabolism" EXACT [] is_a: GO:0018962 ! 3-phenylpropionate metabolic process [Term] id: GO:0046436 name: D-alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid." [CHEBI:15570, GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "D-alanine metabolism" EXACT [] is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0046437 name: D-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "D-amino acid anabolism" EXACT [] synonym: "D-amino acid biosynthesis" EXACT [] synonym: "D-amino acid formation" EXACT [] synonym: "D-amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0046438 name: D-cysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:ai] subset: gosubset_prok synonym: "D-cysteine metabolism" EXACT [] is_a: GO:0006534 ! cysteine metabolic process [Term] id: GO:0046439 name: L-cysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [CHEBI:17561, GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-cysteine metabolism" EXACT [] is_a: GO:0006534 ! cysteine metabolic process [Term] id: GO:0046440 name: L-lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid." [CHEBI:18019, GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-lysine metabolism" EXACT [] is_a: GO:0006553 ! lysine metabolic process [Term] id: GO:0046441 name: D-lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [CHEBI:16855, GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-lysine metabolism" EXACT [] is_a: GO:0006553 ! lysine metabolic process [Term] id: GO:0046442 name: aerobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] subset: gosubset_prok synonym: "aerobactin metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0046443 name: FAD metabolic process namespace: biological_process def: "The chemical reactions and pathways involving FAD, the oxidized form of flavin adenine dinucleotide." [CHEBI:16238, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "FAD metabolism" EXACT [] synonym: "oxidized flavin adenine dinucleotide metabolic process" EXACT [GOC:curators] synonym: "oxidized flavin adenine dinucleotide metabolism" EXACT [GOC:curators] synonym: "oxidized flavin-adenine dinucleotide metabolic process" EXACT [GOC:curators] synonym: "oxidized flavin-adenine dinucleotide metabolism" EXACT [GOC:curators] is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process [Term] id: GO:0046444 name: FMN metabolic process namespace: biological_process def: "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [CHEBI:17621, GOC:ai] subset: gosubset_prok synonym: "FMN metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process [Term] id: GO:0046445 name: benzyl isoquinoline alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "benzyl isoquinoline alkaloid metabolism" EXACT [] is_a: GO:0033076 ! isoquinoline alkaloid metabolic process [Term] id: GO:0046446 name: purine alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] subset: gosubset_prok synonym: "purine alkaloid metabolism" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0046447 name: terpenoid indole alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] subset: gosubset_prok synonym: "terpenoid indole alkaloid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0035834 ! indole alkaloid metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0046448 name: tropane alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "tropane alkaloid metabolism" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046449 name: creatinine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "creatinine metabolism" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process is_a: GO:0072338 ! cellular lactam metabolic process [Term] id: GO:0046450 name: dethiobiotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "desthiobiotin metabolic process" EXACT [] synonym: "desthiobiotin metabolism" EXACT [] synonym: "dethiobiotin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046451 name: diaminopimelate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "diaminopimelate metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0046452 name: dihydrofolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dihydrofolate metabolism" EXACT [] synonym: "dihydrofolate reduction" NARROW [] is_a: GO:0006760 ! folic acid-containing compound metabolic process [Term] id: GO:0046453 name: dipyrrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03] subset: gosubset_prok synonym: "dipyrrin metabolism" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046454 name: dimethylsilanediol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:ai] subset: gosubset_prok synonym: "dimethylsilanediol metabolism" EXACT [] is_a: GO:0018945 ! organosilicon metabolic process is_a: GO:0034311 ! diol metabolic process [Term] id: GO:0046455 name: organosilicon catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon." [GOC:ai] subset: gosubset_prok synonym: "organosilicon breakdown" EXACT [] synonym: "organosilicon catabolism" EXACT [] synonym: "organosilicon degradation" EXACT [] synonym: "organosilicone catabolic process" EXACT [] synonym: "organosilicone catabolism" EXACT [] is_a: GO:0018945 ! organosilicon metabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0046456 name: icosanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "eicosanoid biosynthesis" EXACT [] synonym: "eicosanoid biosynthetic process" EXACT [] synonym: "icosanoid anabolism" EXACT [] synonym: "icosanoid biosynthesis" EXACT [] synonym: "icosanoid formation" EXACT [] synonym: "icosanoid synthesis" EXACT [] xref: Wikipedia:Eicosanoid is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0046457 name: prostanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure." [GOC:ai] subset: gosubset_prok synonym: "prostanoid anabolism" EXACT [] synonym: "prostanoid biosynthesis" EXACT [] synonym: "prostanoid formation" EXACT [] synonym: "prostanoid synthesis" EXACT [] xref: Wikipedia:Prostanoid#Biosynthesis is_a: GO:0006692 ! prostanoid metabolic process is_a: GO:0046456 ! icosanoid biosynthetic process [Term] id: GO:0046458 name: hexadecanal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/] subset: gosubset_prok synonym: "hexadecanal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process [Term] id: GO:0046459 name: short-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids with a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "short-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0046460 name: neutral lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai] subset: gosubset_prok synonym: "neutral lipid anabolism" EXACT [] synonym: "neutral lipid biosynthesis" EXACT [] synonym: "neutral lipid formation" EXACT [] synonym: "neutral lipid synthesis" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0046461 name: neutral lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai] subset: gosubset_prok synonym: "neutral lipid breakdown" EXACT [] synonym: "neutral lipid catabolism" EXACT [] synonym: "neutral lipid degradation" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0046462 name: monoacylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "monoacylglycerol metabolism" EXACT [] synonym: "monoglyceride metabolic process" EXACT [] synonym: "monoglyceride metabolism" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process [Term] id: GO:0046463 name: acylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai] subset: gosubset_prok synonym: "acylglycerol anabolism" EXACT [] synonym: "acylglycerol biosynthesis" EXACT [] synonym: "acylglycerol formation" EXACT [] synonym: "acylglycerol synthesis" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process is_a: GO:0045017 ! glycerolipid biosynthetic process is_a: GO:0046460 ! neutral lipid biosynthetic process is_a: GO:0046504 ! glycerol ether biosynthetic process [Term] id: GO:0046464 name: acylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai] subset: gosubset_prok synonym: "acylglycerol breakdown" EXACT [] synonym: "acylglycerol catabolism" EXACT [] synonym: "acylglycerol degradation" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process is_a: GO:0044269 ! glycerol ether catabolic process is_a: GO:0046461 ! neutral lipid catabolic process is_a: GO:0046503 ! glycerolipid catabolic process [Term] id: GO:0046465 name: dolichyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "dolichyl diphosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0019348 ! dolichol metabolic process [Term] id: GO:0046466 name: membrane lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] subset: gosubset_prok synonym: "membrane lipid breakdown" EXACT [] synonym: "membrane lipid catabolism" EXACT [] synonym: "membrane lipid degradation" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0046467 name: membrane lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] subset: gosubset_prok synonym: "membrane lipid anabolism" EXACT [] synonym: "membrane lipid biosynthesis" EXACT [] synonym: "membrane lipid formation" EXACT [] synonym: "membrane lipid synthesis" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0046468 name: phosphatidyl-N-monomethylethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria." [http://www.lipid.co.uk] subset: gosubset_prok synonym: "phosphatidyl-N-monomethylethanolamine metabolism" EXACT [] synonym: "PMME metabolic process" EXACT [] synonym: "PMME metabolism" EXACT [] is_a: GO:0046337 ! phosphatidylethanolamine metabolic process [Term] id: GO:0046469 name: platelet activating factor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] synonym: "PAF metabolic process" EXACT [] synonym: "PAF metabolism" EXACT [] synonym: "platelet activating factor metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0042439 ! ethanolamine-containing compound metabolic process [Term] id: GO:0046470 name: phosphatidylcholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylcholine metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0042439 ! ethanolamine-containing compound metabolic process [Term] id: GO:0046471 name: phosphatidylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylglycerol metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0046473 name: phosphatidic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidic acid metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046474 name: glycerophospholipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerophospholipid anabolism" EXACT [] synonym: "glycerophospholipid biosynthesis" EXACT [] synonym: "glycerophospholipid formation" EXACT [] synonym: "glycerophospholipid synthesis" EXACT [] synonym: "phosphoglyceride biosynthesis" EXACT [] synonym: "phosphoglyceride biosynthetic process" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0045017 ! glycerolipid biosynthetic process [Term] id: GO:0046475 name: glycerophospholipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerophospholipid breakdown" EXACT [] synonym: "glycerophospholipid catabolism" EXACT [] synonym: "glycerophospholipid degradation" EXACT [] synonym: "phosphoglyceride catabolic process" EXACT [] synonym: "phosphoglyceride catabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0046503 ! glycerolipid catabolic process [Term] id: GO:0046476 name: glycosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "glycosylceramide anabolism" EXACT [] synonym: "glycosylceramide biosynthesis" EXACT [] synonym: "glycosylceramide formation" EXACT [] synonym: "glycosylceramide synthesis" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0046477 name: glycosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "glycosylceramide breakdown" EXACT [] synonym: "glycosylceramide catabolism" EXACT [] synonym: "glycosylceramide degradation" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0019377 ! glycolipid catabolic process is_a: GO:0046514 ! ceramide catabolic process [Term] id: GO:0046478 name: lactosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lactosylceramide metabolism" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0046479 name: glycosphingolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycosphingolipid breakdown" EXACT [] synonym: "glycosphingolipid catabolism" EXACT [] synonym: "glycosphingolipid degradation" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0019377 ! glycolipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process [Term] id: GO:0046480 name: galactolipid galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol." [EC:2.4.1.184] synonym: "3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.184] synonym: "DGDG synthase activity" BROAD [EC:2.4.1.184] synonym: "digalactosyldiacylglycerol synthase activity" BROAD [EC:2.4.1.184] synonym: "galactolipid-galactolipid galactosyltransferase activity" EXACT [EC:2.4.1.184] synonym: "galactolipid:galactolipid galactosyltransferase activity" EXACT [] synonym: "GGGT activity" EXACT [EC:2.4.1.184] synonym: "interlipid galactosyltransferase activity" RELATED [EC:2.4.1.184] xref: EC:2.4.1.184 xref: MetaCyc:RXN-1226 is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0046481 name: digalactosyldiacylglycerol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H(+) + UDP." [EC:2.4.1.241, RHEA:10523] synonym: "DGD1" NARROW [] synonym: "DGD2" NARROW [] synonym: "DGDG synthase activity" BROAD [EC:2.4.1.241] synonym: "UDP-galactose-dependent DGDG synthase activity" EXACT [EC:2.4.1.241] synonym: "UDP-galactose-dependent digalactosyldiacylglycerol synthase activity" EXACT [EC:2.4.1.241] synonym: "UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.241] synonym: "UDP-galactose:MGDG galactosyltransferase activity" EXACT [] xref: EC:2.4.1.241 xref: KEGG:R04469 xref: MetaCyc:RXN-1225 xref: RHEA:10523 xref: Wikipedia:Digalactosyldiacylglycerol_synthase is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0046482 name: para-aminobenzoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11377864, PMID:11960743] subset: gosubset_prok synonym: "4-aminobenzoic acid metabolic process" EXACT [] synonym: "4-aminobenzoic acid metabolism" EXACT [] synonym: "p-aminobenzoic acid metabolic process" EXACT [] synonym: "p-aminobenzoic acid metabolism" EXACT [] synonym: "PABA metabolic process" EXACT [] synonym: "PABA metabolism" EXACT [] synonym: "para-aminobenzoic acid metabolism" EXACT [] synonym: "vitamin Bx metabolic process" EXACT [] synonym: "vitamin Bx metabolism" EXACT [] is_a: GO:0009072 ! aromatic amino acid family metabolic process [Term] id: GO:0046483 name: heterocycle metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "heterocycle metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0046484 name: oxazole or thiazole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [CHEBI:35790, CHEBI:48901, GOC:curators] subset: gosubset_prok synonym: "oxazole or thiazole metabolism" EXACT [] is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046485 name: ether lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:15337120] subset: gosubset_prok synonym: "ether lipid metabolism" EXACT [] synonym: "plasmalogen metabolic process" NARROW [] xref: Wikipedia:Ether_lipid is_a: GO:0006662 ! glycerol ether metabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0046486 name: glycerolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GOC:ai, PMID:8906569] subset: gosubset_prok synonym: "glycerolipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0046487 name: glyoxylate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glyoxylate metabolism" EXACT [] xref: Reactome:1253674 "Glyoxylate metabolism" xref: Reactome:1280606 "Glyoxylate metabolism" xref: Reactome:1299437 "Glyoxylate metabolism" xref: Reactome:1327191 "Glyoxylate metabolism" xref: Reactome:1353286 "Glyoxylate metabolism" xref: Reactome:1373463 "Glyoxylate metabolism" xref: Reactome:1393484 "Glyoxylate metabolism" xref: Reactome:1417984 "Glyoxylate metabolism" xref: Reactome:1451068 "Glyoxylate metabolism" xref: Reactome:1471428 "Glyoxylate metabolism" xref: Reactome:1483379 "Glyoxylate metabolism" xref: Reactome:1497044 "Glyoxylate metabolism" xref: Reactome:1514431 "Glyoxylate metabolism" xref: Reactome:1521294 "Glyoxylate metabolism" xref: Reactome:1527000 "Glyoxylate metabolism" xref: Reactome:1538090 "Glyoxylate metabolism" xref: Reactome:1540370 "Glyoxylate metabolism" xref: Reactome:389661 "Glyoxylate metabolism" is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0046488 name: phosphatidylinositol metabolic process namespace: biological_process alt_id: GO:0030384 def: "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylinositol metabolism" EXACT [] synonym: "phosphoinositide metabolic process" EXACT [] synonym: "phosphoinositide metabolism" EXACT [] synonym: "PtdIns metabolic process" EXACT [] synonym: "PtdIns metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0046490 name: isopentenyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "IPP metabolic process" EXACT [] synonym: "IPP metabolism" EXACT [] synonym: "isopentenyl diphosphate metabolism" EXACT [] synonym: "isopentenyl pyrophosphate metabolic process" EXACT [] synonym: "isopentenyl pyrophosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process [Term] id: GO:0046491 name: L-methylmalonyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-methylmalonyl-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0046492 name: heme b metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25] subset: gosubset_prok synonym: "haem b metabolic process" EXACT [] synonym: "haem b metabolism" EXACT [] synonym: "heme b metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0046493 name: lipid A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipid A metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006664 ! glycolipid metabolic process [Term] id: GO:0046494 name: rhizobactin 1021 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] subset: gosubset_prok synonym: "rhizobactin 1021 metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0046495 name: nicotinamide riboside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [CHEBI:15927, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-ribosylnicotinamide metabolic process" EXACT [CHEBI:15927] synonym: "nicotinamide riboside metabolism" EXACT [] is_a: GO:0070637 ! pyridine nucleoside metabolic process [Term] id: GO:0046496 name: nicotinamide nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nicotinamide nucleotide metabolism" EXACT [] is_a: GO:0019362 ! pyridine nucleotide metabolic process [Term] id: GO:0046497 name: nicotinate nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nicotinate nucleotide metabolism" EXACT [] is_a: GO:0019362 ! pyridine nucleotide metabolic process [Term] id: GO:0046498 name: S-adenosylhomocysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "S-adenosylhomocysteine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0046499 name: S-adenosylmethioninamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] subset: gosubset_prok synonym: "S-adenosylmethioninamine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046500 name: S-adenosylmethionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "S-adenosyl methionine metabolic process" EXACT [] synonym: "S-adenosyl methionine metabolism" EXACT [] synonym: "S-adenosylmethionine metabolism" EXACT [] synonym: "SAM metabolic process" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046501 name: protoporphyrinogen IX metabolic process namespace: biological_process def: "The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the molecular function term 'ferrochelatase activity ; GO:0004325'. subset: gosubset_prok synonym: "protoporphyrinogen IX metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006778 ! porphyrin metabolic process [Term] id: GO:0046502 name: uroporphyrinogen III metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds." [GOC:ai] subset: gosubset_prok synonym: "uroporphyrinogen III metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006778 ! porphyrin metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046503 name: glycerolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] subset: gosubset_prok synonym: "glycerolipid breakdown" EXACT [] synonym: "glycerolipid catabolism" EXACT [] synonym: "glycerolipid degradation" EXACT [] is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0046504 name: glycerol ether biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai] subset: gosubset_prok synonym: "glycerol ether anabolism" EXACT [] synonym: "glycerol ether biosynthesis" EXACT [] synonym: "glycerol ether formation" EXACT [] synonym: "glycerol ether synthesis" EXACT [] is_a: GO:0006662 ! glycerol ether metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0046505 name: sulfolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667] subset: gosubset_prok synonym: "sulfolipid metabolism" EXACT [] synonym: "sulpholipid metabolic process" EXACT [] synonym: "sulpholipid metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0046506 name: sulfolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667] subset: gosubset_prok synonym: "sulfolipid anabolism" EXACT [] synonym: "sulfolipid biosynthesis" EXACT [] synonym: "sulfolipid formation" EXACT [] synonym: "sulfolipid synthesis" EXACT [] synonym: "sulpholipid biosynthesis" EXACT [] synonym: "sulpholipid biosynthetic process" EXACT [] xref: AraCyc:PWYQT-4427 is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046505 ! sulfolipid metabolic process [Term] id: GO:0046507 name: UDPsulfoquinovose synthase activity namespace: molecular_function def: "Catalysis of the reaction: sulfite + UDP-D-glucose = H(2)O + UDP-6-sulfoquinovose." [EC:3.13.1.1, RHEA:13200] synonym: "sulfite:UDP-glucose sulfotransferase activity" EXACT [] synonym: "UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity" EXACT [EC:3.13.1.1] synonym: "UDP-sulfoquinovose synthase activity" EXACT [EC:3.13.1.1] synonym: "UDPsulphoquinovose synthase activity" EXACT [] xref: EC:3.13.1.1 xref: KEGG:R05775 xref: MetaCyc:RXN-1223 xref: RHEA:13200 is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds [Term] id: GO:0046508 name: hydrolase activity, acting on carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl] subset: gosubset_prok synonym: "hydrolase activity, acting on carbon-sulphur bonds" EXACT [] xref: EC:3.13 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0046509 name: 1,2-diacylglycerol 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP." [EC:2.4.1.46, RHEA:14948] synonym: "1-beta-MGDG activity" EXACT [EC:2.4.1.46] synonym: "1beta-MGDG" RELATED [EC:2.4.1.46] synonym: "MGDG synthase activity" EXACT [] synonym: "monogalactosyldiacylglycerol synthase activity" EXACT [] synonym: "UDP galactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] synonym: "UDP-galactose-diacylglyceride galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46] synonym: "UDP-galactose:diacylglycerol galactosyltransferase activity" EXACT [] synonym: "UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46] synonym: "uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] xref: EC:2.4.1.46 xref: KEGG:R02691 xref: MetaCyc:2.4.1.46-RXN xref: RHEA:14948 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0046510 name: UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP." [MetaCyc:RXN-1224] synonym: "sulfolipid synthase" BROAD [] synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT [] xref: MetaCyc:RXN-1224 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0046511 name: sphinganine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] subset: gosubset_prok synonym: "dihydrosphingosine biosynthesis" EXACT [] synonym: "dihydrosphingosine biosynthetic process" EXACT [] synonym: "sphinganine anabolism" EXACT [] synonym: "sphinganine biosynthesis" EXACT [] synonym: "sphinganine formation" EXACT [] synonym: "sphinganine synthesis" EXACT [] is_a: GO:0006667 ! sphinganine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:0046520 ! sphingoid biosynthetic process [Term] id: GO:0046512 name: sphingosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingosine anabolism" EXACT [] synonym: "sphingosine biosynthesis" EXACT [] synonym: "sphingosine formation" EXACT [] synonym: "sphingosine synthesis" EXACT [] is_a: GO:0006670 ! sphingosine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:0046520 ! sphingoid biosynthetic process [Term] id: GO:0046513 name: ceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai] subset: gosubset_prok synonym: "ceramide anabolism" EXACT [] synonym: "ceramide biosynthesis" EXACT [] synonym: "ceramide formation" EXACT [] synonym: "ceramide synthesis" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0046520 ! sphingoid biosynthetic process [Term] id: GO:0046514 name: ceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai] subset: gosubset_prok synonym: "ceramide breakdown" EXACT [] synonym: "ceramide catabolism" EXACT [] synonym: "ceramide degradation" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0046521 ! sphingoid catabolic process [Term] id: GO:0046516 name: hypusine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ai] subset: gosubset_prok synonym: "hypusine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0046517 name: octamethylcyclotetrasiloxane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/] subset: gosubset_prok synonym: "octamethylcyclotetrasiloxane breakdown" EXACT [] synonym: "octamethylcyclotetrasiloxane catabolism" EXACT [] synonym: "octamethylcyclotetrasiloxane degradation" EXACT [] is_a: GO:0046455 ! organosilicon catabolic process is_a: GO:0046518 ! octamethylcyclotetrasiloxane metabolic process [Term] id: GO:0046518 name: octamethylcyclotetrasiloxane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/] subset: gosubset_prok synonym: "octamethylcyclotetrasiloxane metabolism" EXACT [] is_a: GO:0018945 ! organosilicon metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046519 name: sphingoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingoid base metabolic process" EXACT [] synonym: "sphingoid base metabolism" EXACT [] synonym: "sphingoid metabolism" EXACT [] is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0046520 name: sphingoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingoid anabolism" EXACT [] synonym: "sphingoid biosynthesis" EXACT [] synonym: "sphingoid formation" EXACT [] synonym: "sphingoid synthesis" EXACT [] is_a: GO:0030148 ! sphingolipid biosynthetic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0046521 name: sphingoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingoid breakdown" EXACT [] synonym: "sphingoid catabolism" EXACT [] synonym: "sphingoid degradation" EXACT [] is_a: GO:0030149 ! sphingolipid catabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0046522 name: S-methyl-5-thioribose kinase activity namespace: molecular_function def: "Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.100, RHEA:22315] subset: gosubset_prok synonym: "5-methylthioribose kinase (phosphorylating)" EXACT [EC:2.7.1.100] synonym: "5-methylthioribose kinase activity" EXACT [] synonym: "ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100] synonym: "ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100] synonym: "methylthioribose kinase activity" EXACT [EC:2.7.1.100] synonym: "MTR kinase activity" EXACT [EC:2.7.1.100] xref: EC:2.7.1.100 xref: KEGG:R04143 xref: MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN xref: RHEA:22315 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0046523 name: S-methyl-5-thioribose-1-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [EC:5.3.1.23, RHEA:19992] subset: gosubset_prok synonym: "1-phospho-5'-S-methylthioribose isomerase activity" EXACT [EC:5.3.1.23] synonym: "1-PMTR isomerase activity" EXACT [EC:5.3.1.23] synonym: "5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23] synonym: "5-methylthioribose-1-phosphate isomerase activity" EXACT [] synonym: "methylthioribose 1-phosphate isomerase activity" EXACT [EC:5.3.1.23] synonym: "MTR-1-P isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] xref: EC:5.3.1.23 xref: KEGG:R04420 xref: MetaCyc:5.3.1.23-RXN xref: RHEA:19992 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0046524 name: sucrose-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate." [EC:2.4.1.14] subset: gosubset_prok synonym: "SPS" RELATED [EC:2.4.1.14] synonym: "sucrose 6-phosphate synthase activity" EXACT [EC:2.4.1.14] synonym: "sucrose phosphate synthetase activity" EXACT [EC:2.4.1.14] synonym: "sucrose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "sucrosephosphate-UDP glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDP-glucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDPglucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "uridine diphosphoglucose-fructose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] xref: EC:2.4.1.14 xref: MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0046525 name: xylosylprotein 4-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.133] synonym: "galactosyltransferase I activity" RELATED [EC:2.4.1.133] synonym: "UDP-D-galactose:D-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "UDP-D-galactose:xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "UDP-galactose:xylose galactosyltransferase activity" EXACT [] synonym: "UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "uridine diphosphogalactose-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] xref: EC:2.4.1.133 xref: MetaCyc:2.4.1.133-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0046526 name: D-xylulose reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH." [EC:1.1.1.9, RHEA:20436] subset: gosubset_prok synonym: "xylitol dehydrogenase activity" EXACT [EC:1.1.1.9] xref: EC:1.1.1.9 xref: KEGG:R01896 xref: MetaCyc:D-XYLULOSE-REDUCTASE-RXN xref: RHEA:20436 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: GO:0031320 ! hexitol dehydrogenase activity [Term] id: GO:0046527 name: glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0046528 name: imaginal disc fusion namespace: biological_process def: "The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis." [PMID:11494317] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0046529 name: imaginal disc fusion, thorax closure namespace: biological_process def: "The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0046528 ! imaginal disc fusion [Term] id: GO:0046530 name: photoreceptor cell differentiation namespace: biological_process alt_id: GO:0007467 def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0046532 name: regulation of photoreceptor cell differentiation namespace: biological_process alt_id: GO:0045673 def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045664 ! regulation of neuron differentiation relationship: regulates GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0046533 name: negative regulation of photoreceptor cell differentiation namespace: biological_process alt_id: GO:0045674 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "down regulation of photoreceptor cell differentiation" EXACT [] synonym: "down regulation of photoreceptor differentiation" EXACT [] synonym: "down-regulation of photoreceptor cell differentiation" EXACT [] synonym: "down-regulation of photoreceptor differentiation" EXACT [] synonym: "downregulation of photoreceptor cell differentiation" EXACT [] synonym: "downregulation of photoreceptor differentiation" EXACT [] synonym: "inhibition of photoreceptor cell differentiation" NARROW [] synonym: "inhibition of photoreceptor differentiation" NARROW [] synonym: "negative regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0046534 name: positive regulation of photoreceptor cell differentiation namespace: biological_process alt_id: GO:0045675 def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "activation of photoreceptor cell differentiation" NARROW [] synonym: "activation of photoreceptor differentiation" NARROW [] synonym: "positive regulation of photoreceptor differentiation" EXACT [] synonym: "stimulation of photoreceptor cell differentiation" NARROW [] synonym: "stimulation of photoreceptor differentiation" NARROW [] synonym: "up regulation of photoreceptor cell differentiation" EXACT [] synonym: "up regulation of photoreceptor differentiation" EXACT [] synonym: "up-regulation of photoreceptor cell differentiation" EXACT [] synonym: "up-regulation of photoreceptor differentiation" EXACT [] synonym: "upregulation of photoreceptor cell differentiation" EXACT [] synonym: "upregulation of photoreceptor differentiation" EXACT [] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0046535 name: detection of chemical stimulus involved in sensory perception of umami taste namespace: biological_process def: "The series of events required for a umami taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates." [GOC:ai, PMID:11894099] synonym: "perception of umami taste, detection of chemical stimulus" EXACT [] synonym: "perception of umami taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of umami taste" EXACT [] synonym: "sensory detection of umami taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of umami taste" EXACT [] synonym: "sensory transduction of umami taste" EXACT [] synonym: "umami taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050917 ! sensory perception of umami taste [Term] id: GO:0046536 name: dosage compensation complex namespace: cellular_component def: "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kmv, GOC:mah] subset: goslim_pir is_a: GO:0032991 ! macromolecular complex is_a: GO:0044427 ! chromosomal part is_a: GO:0044428 ! nuclear part relationship: part_of GO:0000803 ! sex chromosome [Term] id: GO:0046537 name: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] subset: gosubset_prok synonym: "PGAM-i" RELATED [EC:5.4.2.1] is_a: GO:0004619 ! phosphoglycerate mutase activity [Term] id: GO:0046538 name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] subset: gosubset_prok synonym: "glycerate phosphomutase (diphosphoglycerate cofactor) activity" EXACT [EC:5.4.2.1] synonym: "PGAM-d" RELATED [EC:5.4.2.1] is_a: GO:0004619 ! phosphoglycerate mutase activity [Term] id: GO:0046539 name: histamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.8, RHEA:19304] synonym: "histamine 1-methyltransferase activity" EXACT [EC:2.1.1.8] synonym: "histamine methyltransferase activity" EXACT [EC:2.1.1.8] synonym: "histamine-methylating enzyme" RELATED [EC:2.1.1.8] synonym: "imidazolemethyltransferase activity" EXACT [EC:2.1.1.8] synonym: "S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity" EXACT [EC:2.1.1.8] synonym: "S-adenosylmethionine-histamine N-methyltransferase activity" EXACT [EC:2.1.1.8] xref: EC:2.1.1.8 xref: KEGG:R02155 xref: MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN xref: RHEA:19304 is_a: GO:0008170 ! N-methyltransferase activity [Term] id: GO:0046540 name: U4/U6 x U5 tri-snRNP complex namespace: cellular_component def: "A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins." [PMID:11867543] synonym: "U4/U6 . U5 snRNP complex" EXACT [] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0046541 name: saliva secretion namespace: biological_process def: "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." [GOC:curators, UBERON:0001836] synonym: "salivation" EXACT [] xref: Wikipedia:Salivation is_a: GO:0007589 ! body fluid secretion is_a: GO:0022600 ! digestive system process [Term] id: GO:0046542 name: alpha-factor export namespace: biological_process def: "OBSOLETE. The directed movement of alpha-factor, one of the two yeast mating factors, out of a cell." [GOC:ai] comment: This term was made obsolete because it is a gene product based term and it does not involve a unique process. is_obsolete: true consider: GO:0015833 [Term] id: GO:0046543 name: development of secondary female sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." [GOC:ai] is_a: GO:0045136 ! development of secondary sexual characteristics relationship: part_of GO:0046660 ! female sex differentiation [Term] id: GO:0046544 name: development of secondary male sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." [GOC:ai] is_a: GO:0045136 ! development of secondary sexual characteristics relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0046545 name: development of primary female sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0045137 ! development of primary sexual characteristics relationship: part_of GO:0046660 ! female sex differentiation [Term] id: GO:0046546 name: development of primary male sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0045137 ! development of primary sexual characteristics relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0046547 name: trans-aconitate 3-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.145, RHEA:22203] synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity" EXACT [EC:2.1.1.145] xref: EC:2.1.1.145 xref: KEGG:R05764 xref: MetaCyc:2.1.1.145-RXN xref: RHEA:22203 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0046548 name: retinal rod cell development namespace: biological_process def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042462 ! eye photoreceptor cell development [Term] id: GO:0046549 name: retinal cone cell development namespace: biological_process def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042462 ! eye photoreceptor cell development relationship: part_of GO:0042670 ! retinal cone cell differentiation [Term] id: GO:0046550 name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine namespace: biological_process def: "The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7." [RESID:AA0328] subset: gosubset_prok synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine" EXACT [] synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine" EXACT [] synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine" EXACT [] xref: RESID:AA0328 is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0046551 name: retinal cone cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:mtg_sensu, PMID:3076112, PMID:3937883] is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment relationship: part_of GO:0042670 ! retinal cone cell differentiation [Term] id: GO:0046552 name: photoreceptor cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0046553 name: D-malate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-malate + NAD(+) = CO(2) + NADH + pyruvate." [EC:1.1.1.83, RHEA:18368] synonym: "(R)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.83] synonym: "bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)" RELATED [EC:1.1.1.83] synonym: "D-malate dehydrogenase activity" EXACT [EC:1.1.1.83] synonym: "D-malic enzyme" RELATED [EC:1.1.1.83] xref: EC:1.1.1.83 xref: KEGG:R00215 xref: MetaCyc:1.1.1.83-RXN xref: RHEA:18368 is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0046554 name: malate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [EC:1.1.1.82] subset: gosubset_prok synonym: "(S)-malate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.82] synonym: "malate NADP dehydrogenase activity" EXACT [EC:1.1.1.82] synonym: "malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.82] synonym: "NADP malate dehydrogenase activity" EXACT [EC:1.1.1.82] synonym: "NADP-linked malate dehydrogenase activity" EXACT [EC:1.1.1.82] synonym: "NADP-malate dehydrogenase activity" EXACT [EC:1.1.1.82] xref: EC:1.1.1.82 xref: MetaCyc:MALATE-DEHYDROGENASE-NADP+-RXN is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0046555 name: acetylxylan esterase activity namespace: molecular_function def: "Catalysis of the deacetylation of xylans and xylo-oligosaccharides." [EC:3.1.1.72] subset: gosubset_prok xref: EC:3.1.1.72 xref: MetaCyc:3.1.1.72-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0046556 name: alpha-N-arabinofuranosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55] subset: gosubset_prok synonym: "alpha-arabinofuranosidase activity" EXACT [EC:3.2.1.55] synonym: "alpha-arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinanase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinofuranosidase activity" EXACT [] synonym: "alpha-L-arabinofuranoside arabinofuranohydrolase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinofuranoside hydrolase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "arabinofuranosidase activity" EXACT [EC:3.2.1.55] synonym: "arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "L-arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "polysaccharide alpha-L-arabinofuranosidase activity" EXACT [] xref: EC:3.2.1.55 xref: MetaCyc:3.2.1.55-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0046557 name: glucan endo-1,6-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,6-linkages in 1,6-beta-D-glucans." [EC:3.2.1.75] synonym: "1,6-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucan hydrolase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucanase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucanase-pustulanase activity" EXACT [EC:3.2.1.75] synonym: "beta-1->6-glucan hydrolase activity" EXACT [EC:3.2.1.75] synonym: "endo-(1,6)-beta-D-glucanase activity" EXACT [] synonym: "endo-(1->6)-beta-D-glucanase activity" EXACT [EC:3.2.1.75] synonym: "endo-1,6-beta-D-glucanase activity" EXACT [EC:3.2.1.75] synonym: "endo-1,6-beta-glucanase activity" EXACT [EC:3.2.1.75] synonym: "endo-beta-1,6-glucanase activity" EXACT [EC:3.2.1.75] xref: EC:3.2.1.75 xref: MetaCyc:3.2.1.75-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0046558 name: arabinan endo-1,5-alpha-L-arabinosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,5-alpha-arabinofuranosidic linkages in 1,5-arabinans." [EC:3.2.1.99] subset: gosubset_prok synonym: "1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity" EXACT [EC:3.2.1.99] synonym: "endo-1,5-a-L-arabinanase activity" EXACT [] synonym: "endo-1,5-alpha-L-arabinanase activity" EXACT [EC:3.2.1.99] synonym: "endo-alpha-1,5-arabanase activity" EXACT [EC:3.2.1.99] synonym: "endo-arabanase activity" EXACT [EC:3.2.1.99] xref: EC:3.2.1.99 xref: MetaCyc:3.2.1.99-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0046559 name: alpha-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.139] subset: gosubset_prok synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" EXACT [EC:3.2.1.139] synonym: "alpha-glucosiduronase activity" EXACT [EC:3.2.1.139] xref: EC:3.2.1.139 xref: MetaCyc:3.2.1.139-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0046560 name: scytalidopepsin B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." [EC:3.4.23.32] comment: This term was made obsolete because it represents a gene product. synonym: "Ganoderma lucidum aspartic proteinase activity" EXACT [EC:3.4.23.32] synonym: "Ganoderma lucidum carboxyl proteinase activity" EXACT [EC:3.4.23.32] synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32] synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32] synonym: "SLB" RELATED [EC:3.4.23.32] xref: EC:3.4.23.32 xref: MetaCyc:3.4.23.32-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0046561 name: penicillopepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." [EC:3.4.23.20] comment: This term was made obsolete because it represents a gene product. synonym: "acid protease A" EXACT [] synonym: "Penicillium aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium caseicolum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium citrinum acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium citrinum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium cyclopium acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium duponti aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium expansum acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium expansum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium janthinellum acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium janthinellum aspartic protease activity" EXACT [EC:3.4.23.20] synonym: "Penicillium janthinellum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium roqueforti acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "peptidase A activity" BROAD [EC:3.4.23.20] xref: EC:3.4.23.20 xref: MetaCyc:3.4.23.20-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0046562 name: glucose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.4, GOC:mah] synonym: "beta-D-glucose oxidase activity" EXACT [] synonym: "beta-D-glucose:oxygen 1-oxido-reductase activity" EXACT [EC:1.1.3.4] synonym: "beta-D-glucose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.4] synonym: "beta-D-glucose:quinone oxidoreductase activity" EXACT [EC:1.1.3.4] synonym: "corylophyline" RELATED [EC:1.1.3.4] synonym: "D-glucose oxidase activity" EXACT [EC:1.1.3.4] synonym: "D-glucose-1-oxidase activity" EXACT [EC:1.1.3.4] synonym: "deoxin-1" RELATED [EC:1.1.3.4] synonym: "glucose aerodehydrogenase activity" EXACT [EC:1.1.3.4] synonym: "glucose oxyhydrase activity" EXACT [EC:1.1.3.4] synonym: "GOD activity" RELATED [EC:1.1.3.4] synonym: "microcid" RELATED [EC:1.1.3.4] synonym: "penatin" RELATED [EC:1.1.3.4] xref: EC:1.1.3.4 xref: KEGG:R01522 xref: MetaCyc:GLUCOSE-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0046563 name: methanol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde." [MetaCyc:METHANOL-OXIDASE-RXN] comment: Note that EC:1.1.3.31 was deleted from EC as it cannot be distinguished from alcohol oxidase (EC:1.1.3.13). xref: EC:1.1.3.- xref: MetaCyc:METHANOL-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0046564 name: oxalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + oxalate = CO(2) + formate." [EC:4.1.1.2, RHEA:16512] subset: gosubset_prok synonym: "oxalate carboxy-lyase (formate-forming)" EXACT [EC:4.1.1.2] synonym: "oxalate carboxy-lyase activity" EXACT [EC:4.1.1.2] xref: EC:4.1.1.2 xref: KEGG:R00522 xref: MetaCyc:OXALATE-DECARBOXYLASE-RXN xref: RHEA:16512 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0046565 name: 3-dehydroshikimate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate." [EC:4.2.1.-, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN] xref: EC:4.2.1.- xref: MetaCyc:DHSHIKIMATE-DEHYDRO-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0046566 name: DOPA dioxygenase activity namespace: molecular_function def: "Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid." [PMID:11711071] synonym: "dihydroxyphenylalanine dioxygenase activity" EXACT [] xref: MetaCyc:RXN-8460 is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0046567 name: aphidicolan-16 beta-ol synthase activity namespace: molecular_function def: "Catalysis of the formation of aphidicolan-16 beta-ol from geranylgeranyl diphosphate." [PMID:12149019] is_a: GO:0016829 ! lyase activity [Term] id: GO:0046568 name: 3-methylbutanol:NAD(P) oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265] synonym: "3-methylbutanal reductase [NAD(P)] activity" EXACT [EC:1.1.1.265] synonym: "3-methylbutanol:NAD(P) oxidoreductase activity" EXACT [] synonym: "3-methylbutyraldehyde reductase activity" EXACT [] synonym: "isoamyl alcohol oxidase activity" EXACT [] xref: EC:1.1.1.265 xref: MetaCyc:1.1.1.265-RXN is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity [Term] id: GO:0046569 name: glyoxal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2." [EC:1.2.3.-, PMID:11733005] synonym: "GLOX" EXACT [] xref: EC:1.2.3.- is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0046570 name: methylthioribulose 1-phosphate dehydratase activity namespace: molecular_function alt_id: GO:0043809 def: "Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O." [EC:4.2.1.109, RHEA:15552] synonym: "1-PMT-ribulose dehydratase activity" EXACT [EC:4.2.1.109] synonym: "5-methylthioribulose-1-phosphate 4-dehydratase activity" EXACT [MetaCyc:R145-RXN] synonym: "methylthioribulose-1-phosphate dehydratase activity" EXACT [] synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" RELATED [EC:4.2.1.109] synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity" EXACT [] synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" EXACT [] xref: EC:4.2.1.109 xref: KEGG:R07392 xref: MetaCyc:R145-RXN xref: RHEA:15552 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0046571 name: aspartate-2-keto-4-methylthiobutyrate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate." [MetaCyc:R15-RXN] xref: EC:2.6.1.- is_a: GO:0008483 ! transaminase activity [Term] id: GO:0046572 name: versicolorin B synthase activity namespace: molecular_function def: "Catalysis of the reaction: versiconal = versicolorin B + H2O." [MetaCyc:RXN-9494, PMID:8784203] xref: MetaCyc:RXN-9494 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0046573 name: lactonohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group." [PMID:11640988] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0046574 name: glycuronidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid." [PMID:10441389, PMID:12044176] synonym: "glucuronyl hydrolase activity" EXACT [] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0046575 name: rhamnogalacturonan acetylesterase activity namespace: molecular_function def: "Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan." [PMID:10801485] is_a: GO:0008126 ! acetylesterase activity [Term] id: GO:0046576 name: rhamnogalacturonase B activity namespace: molecular_function def: "Catalysis of the cleavage of (1,2)-alpha-L-Rhap-(1,4)-alpha-D-GalpA glycosidic linkage, generating oligosaccharides terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue." [PMID:8587995, PMID:8720076] is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0046577 name: long-chain-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O." [EC:1.1.3.20] synonym: "fatty alcohol oxidase activity" EXACT [] synonym: "fatty alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20] synonym: "long-chain fatty acid oxidase activity" EXACT [EC:1.1.3.20] synonym: "long-chain fatty alcohol oxidase activity" EXACT [] synonym: "long-chain-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20] xref: EC:1.1.3.20 xref: MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0046578 name: regulation of Ras protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction relationship: regulates GO:0007265 ! Ras protein signal transduction [Term] id: GO:0046579 name: positive regulation of Ras protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] synonym: "activation of Ras protein signal transduction" NARROW [] synonym: "stimulation of Ras protein signal transduction" NARROW [] synonym: "up regulation of Ras protein signal transduction" EXACT [] synonym: "up-regulation of Ras protein signal transduction" EXACT [] synonym: "upregulation of Ras protein signal transduction" EXACT [] is_a: GO:0046578 ! regulation of Ras protein signal transduction is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction relationship: positively_regulates GO:0007265 ! Ras protein signal transduction [Term] id: GO:0046580 name: negative regulation of Ras protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] synonym: "down regulation of Ras protein signal transduction" EXACT [] synonym: "down-regulation of Ras protein signal transduction" EXACT [] synonym: "downregulation of Ras protein signal transduction" EXACT [] synonym: "inhibition of Ras protein signal transduction" NARROW [] is_a: GO:0046578 ! regulation of Ras protein signal transduction is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction relationship: negatively_regulates GO:0007265 ! Ras protein signal transduction [Term] id: GO:0046581 name: intercellular canaliculus namespace: cellular_component def: "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0046582 name: Rap GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rap family." [GOC:mah] synonym: "Rap GAP activity" EXACT [GOC:pg] is_a: GO:0005099 ! Ras GTPase activator activity [Term] id: GO:0046583 name: cation efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "cation efflux permease activity" EXACT [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0046584 name: enniatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "enniatin metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0050761 ! depsipeptide metabolic process [Term] id: GO:0046585 name: enniatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "enniatin anabolism" EXACT [] synonym: "enniatin biosynthesis" EXACT [] synonym: "enniatin formation" EXACT [] synonym: "enniatin synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046584 ! enniatin metabolic process is_a: GO:0050763 ! depsipeptide biosynthetic process [Term] id: GO:0046586 name: regulation of calcium-dependent cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:ai] is_a: GO:0022407 ! regulation of cell-cell adhesion relationship: regulates GO:0016339 ! calcium-dependent cell-cell adhesion [Term] id: GO:0046587 name: positive regulation of calcium-dependent cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai] synonym: "activation of calcium-dependent cell-cell adhesion" NARROW [] synonym: "stimulation of calcium-dependent cell-cell adhesion" NARROW [] synonym: "up regulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "up-regulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "upregulation of calcium-dependent cell-cell adhesion" EXACT [] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion relationship: positively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion [Term] id: GO:0046588 name: negative regulation of calcium-dependent cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai] synonym: "down regulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "down-regulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "downregulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "inhibition of calcium-dependent cell-cell adhesion" NARROW [] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion relationship: negatively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion [Term] id: GO:0046589 name: ribonuclease T1 activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.3] subset: gosubset_prok synonym: "Aspergillus oryzae ribonuclease activity" NARROW [EC:3.1.27.3] synonym: "binase activity" EXACT [EC:3.1.27.3] synonym: "guanyl-specific RNase activity" EXACT [EC:3.1.27.3] synonym: "guanyloribonuclease activity" EXACT [EC:3.1.27.3] synonym: "ribonuclease C2" RELATED [EC:3.1.27.3] synonym: "ribonuclease Ch" RELATED [EC:3.1.27.3] synonym: "ribonuclease F1" EXACT [] synonym: "ribonuclease guaninenucleotido-2'-transferase (cyclizing)" EXACT [EC:3.1.27.3] synonym: "ribonuclease N1" RELATED [EC:3.1.27.3] synonym: "ribonuclease N3" RELATED [EC:3.1.27.3] synonym: "ribonuclease PP1" RELATED [EC:3.1.27.3] synonym: "ribonuclease SA" RELATED [EC:3.1.27.3] synonym: "ribonuclease U1" RELATED [EC:3.1.27.3] synonym: "RNase F1" RELATED [EC:3.1.27.3] synonym: "RNase G" RELATED [EC:3.1.27.3] synonym: "RNase N1 activity" EXACT [EC:3.1.27.3] synonym: "RNase N2 activity" EXACT [EC:3.1.27.3] synonym: "RNase Sa" RELATED [EC:3.1.27.3] synonym: "RNase T1" RELATED [EC:3.1.27.3] synonym: "RNase T1 activity" EXACT [] xref: EC:3.1.27.3 xref: MetaCyc:3.1.27.3-RXN is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0046590 name: embryonic leg morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf] is_a: GO:0030326 ! embryonic limb morphogenesis is_a: GO:0035110 ! leg morphogenesis [Term] id: GO:0046591 name: embryonic leg joint morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the leg joint are generated and organized. A leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner." [GOC:bf, ISBN:0582227089, PMID:12051824] is_a: GO:0035111 ! leg joint morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0046590 ! embryonic leg morphogenesis [Term] id: GO:0046592 name: polyamine oxidase activity namespace: molecular_function def: "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380] synonym: "1-N-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11] synonym: "N1-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11] xref: EC:1.5.3.11 xref: MetaCyc:POLYAMINE-OXIDASE-RXN xref: Reactome:25469 "polyamine oxidase activity" is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0046593 name: mandelonitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde." [EC:4.1.2.10] synonym: "(R)-oxynitrilase activity" EXACT [EC:4.1.2.10] synonym: "D-alpha-hydroxynitrile lyase activity" EXACT [EC:4.1.2.10] synonym: "D-oxynitrilase activity" EXACT [EC:4.1.2.10] synonym: "hydroxynitrile lyase activity" BROAD [] synonym: "mandelonitrile benzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.10] synonym: "mandelonitrile benzaldehyde-lyase activity" EXACT [EC:4.1.2.10] xref: EC:4.1.2.10 xref: MetaCyc:MANDELONITRILE-LYASE-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0046594 name: maintenance of pole plasm mRNA location namespace: biological_process alt_id: GO:0048122 def: "The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:tb] synonym: "maintenance of oocyte pole plasm mRNA localization" EXACT [] synonym: "maintenance of pole plasm mRNA localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051237 ! maintenance of RNA location relationship: part_of GO:0019094 ! pole plasm mRNA localization [Term] id: GO:0046595 name: establishment of pole plasm mRNA localization namespace: biological_process alt_id: GO:0048121 def: "Any process that results in the directed movement of mRNA to the oocyte pole plasm." [GOC:bf] synonym: "establishment of oocyte pole plasm mRNA localization" EXACT [] synonym: "establishment of pole plasm mRNA localisation" EXACT [GOC:mah] is_a: GO:0051236 ! establishment of RNA localization relationship: part_of GO:0019094 ! pole plasm mRNA localization [Term] id: GO:0046596 name: regulation of virion penetration into host cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the introduction of virus particles into the cell." [GOC:ai, GOC:tb] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0050792 ! regulation of viral reproduction is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0019063 ! virion penetration into host cell [Term] id: GO:0046597 name: negative regulation of virion penetration into host cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of virus particles into the cell." [GOC:ai, GOC:tb] synonym: "down regulation of virion penetration into host" EXACT [] synonym: "down-regulation of virion penetration into host" EXACT [] synonym: "downregulation of virion penetration into host" EXACT [] synonym: "inhibition of virion penetration into host" NARROW [] is_a: GO:0046596 ! regulation of virion penetration into host cell is_a: GO:0048525 ! negative regulation of viral reproduction is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0019063 ! virion penetration into host cell [Term] id: GO:0046598 name: positive regulation of virion penetration into host cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of virus particles into the cell." [GOC:ai, GOC:tb] synonym: "activation of virion penetration into host" NARROW [] synonym: "stimulation of virion penetration into host" NARROW [] synonym: "up regulation of virion penetration into host" EXACT [] synonym: "up-regulation of virion penetration into host" EXACT [] synonym: "upregulation of virion penetration into host" EXACT [] is_a: GO:0046596 ! regulation of virion penetration into host cell is_a: GO:0048524 ! positive regulation of viral reproduction is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0019063 ! virion penetration into host cell [Term] id: GO:0046599 name: regulation of centriole replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai] is_a: GO:0010824 ! regulation of centrosome duplication relationship: regulates GO:0007099 ! centriole replication [Term] id: GO:0046600 name: negative regulation of centriole replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication." [GOC:ai] synonym: "down regulation of centriole replication" EXACT [] synonym: "down-regulation of centriole replication" EXACT [] synonym: "downregulation of centriole replication" EXACT [] synonym: "inhibition of centriole replication" NARROW [] is_a: GO:0046599 ! regulation of centriole replication is_a: GO:0046606 ! negative regulation of centrosome cycle is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0007099 ! centriole replication [Term] id: GO:0046601 name: positive regulation of centriole replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai] synonym: "activation of centriole replication" NARROW [] synonym: "stimulation of centriole replication" NARROW [] synonym: "up regulation of centriole replication" EXACT [] synonym: "up-regulation of centriole replication" EXACT [] synonym: "upregulation of centriole replication" EXACT [] is_a: GO:0046599 ! regulation of centriole replication is_a: GO:0046607 ! positive regulation of centrosome cycle is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0007099 ! centriole replication [Term] id: GO:0046602 name: regulation of mitotic centrosome separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai] is_a: GO:0007088 ! regulation of mitosis is_a: GO:0046605 ! regulation of centrosome cycle relationship: regulates GO:0007100 ! mitotic centrosome separation [Term] id: GO:0046603 name: negative regulation of mitotic centrosome separation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centrosome separation." [GOC:ai] synonym: "down regulation of mitotic centrosome separation" EXACT [] synonym: "down-regulation of mitotic centrosome separation" EXACT [] synonym: "downregulation of mitotic centrosome separation" EXACT [] synonym: "inhibition of mitotic centrosome separation" NARROW [] is_a: GO:0046602 ! regulation of mitotic centrosome separation is_a: GO:0046606 ! negative regulation of centrosome cycle relationship: negatively_regulates GO:0007100 ! mitotic centrosome separation [Term] id: GO:0046604 name: positive regulation of mitotic centrosome separation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai] synonym: "activation of mitotic centrosome separation" NARROW [] synonym: "stimulation of mitotic centrosome separation" NARROW [] synonym: "up regulation of mitotic centrosome separation" EXACT [] synonym: "up-regulation of mitotic centrosome separation" EXACT [] synonym: "upregulation of mitotic centrosome separation" EXACT [] is_a: GO:0046602 ! regulation of mitotic centrosome separation is_a: GO:0046607 ! positive regulation of centrosome cycle relationship: positively_regulates GO:0007100 ! mitotic centrosome separation [Term] id: GO:0046605 name: regulation of centrosome cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: regulates GO:0007098 ! centrosome cycle [Term] id: GO:0046606 name: negative regulation of centrosome cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai] synonym: "down regulation of centrosome cycle" EXACT [] synonym: "down-regulation of centrosome cycle" EXACT [] synonym: "downregulation of centrosome cycle" EXACT [] synonym: "inhibition of centrosome cycle" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0046605 ! regulation of centrosome cycle relationship: negatively_regulates GO:0007098 ! centrosome cycle [Term] id: GO:0046607 name: positive regulation of centrosome cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai] synonym: "activation of centrosome cycle" NARROW [] synonym: "stimulation of centrosome cycle" NARROW [] synonym: "up regulation of centrosome cycle" EXACT [] synonym: "up-regulation of centrosome cycle" EXACT [] synonym: "upregulation of centrosome cycle" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0046605 ! regulation of centrosome cycle is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0007098 ! centrosome cycle [Term] id: GO:0046608 name: carotenoid isomerase activity namespace: molecular_function def: "Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids." [PMID:11884677] is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0046609 name: voltage-gated sulfate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + solute(in) = solute(in) + sulfate(out), by a channel in a cell membrane whose opening is governed by the membrane potential." [GOC:mah] synonym: "prestin" NARROW [] synonym: "voltage gated sulfate antiporter activity" EXACT [] synonym: "voltage-dependent sulfate antiporter activity" EXACT [] synonym: "voltage-sensitive sulfate antiporter activity" EXACT [] synonym: "voltage-sensitive sulphate antiporter activity" EXACT [] is_a: GO:0015297 ! antiporter activity [Term] id: GO:0046610 name: lysosomal proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] synonym: "lysosomal hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0000220 ! vacuolar proton-transporting V-type ATPase, V0 domain relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex [Term] id: GO:0046611 name: lysosomal proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] synonym: "lysosomal hydrogen-translocating V-type ATPase complex" EXACT [] synonym: "lysosomal membrane hydrogen-transporting ATPase" BROAD [] is_a: GO:0016471 ! vacuolar proton-transporting V-type ATPase complex relationship: part_of GO:0005765 ! lysosomal membrane [Term] id: GO:0046612 name: lysosomal proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] synonym: "lysosomal hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0000221 ! vacuolar proton-transporting V-type ATPase, V1 domain relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex [Term] id: GO:0046615 name: re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. The resumption of the Saccharomyces mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449] comment: This term was made obsolete because there is no evidence that this process is unique to Saccharomyces. is_obsolete: true replaced_by: GO:0000321 [Term] id: GO:0046617 name: nucleolar size increase (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. The process of nucleolar expansion, as seen in Saccharomyces." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0007571 consider: GO:0007576 [Term] id: GO:0046618 name: drug export namespace: biological_process def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle." [GOC:go_curators] is_a: GO:0015893 ! drug transport [Term] id: GO:0046619 name: optic placode formation involved in camera-type eye formation namespace: biological_process def: "Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] synonym: "optic placode formation in camera-type eye" EXACT [] synonym: "optic placode formation involved in camera-style eye" EXACT [] is_a: GO:0001743 ! optic placode formation relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0046620 name: regulation of organ growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0040008 ! regulation of growth relationship: regulates GO:0035265 ! organ growth [Term] id: GO:0046621 name: negative regulation of organ growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0045926 ! negative regulation of growth is_a: GO:0046620 ! regulation of organ growth relationship: negatively_regulates GO:0035265 ! organ growth [Term] id: GO:0046622 name: positive regulation of organ growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0045927 ! positive regulation of growth is_a: GO:0046620 ! regulation of organ growth relationship: positively_regulates GO:0035265 ! organ growth [Term] id: GO:0046623 name: sphingolipid-translocating ATPase activity namespace: molecular_function def: "Catalysis of the movement of sphingolipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP." [GOC:ai, PMID:12034738] synonym: "sphingolipid flippase activity" EXACT [] is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances is_a: GO:0046624 ! sphingolipid transporter activity [Term] id: GO:0046624 name: sphingolipid transporter activity namespace: molecular_function def: "Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0046625 name: sphingolipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0008289 ! lipid binding [Term] id: GO:0046626 name: regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "regulation of insulin receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0046627 name: negative regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "down regulation of insulin receptor signaling pathway" EXACT [] synonym: "down-regulation of insulin receptor signaling pathway" EXACT [] synonym: "downregulation of insulin receptor signaling pathway" EXACT [] synonym: "inhibition of insulin receptor signaling pathway" NARROW [] synonym: "negative regulation of insulin receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0046626 ! regulation of insulin receptor signaling pathway relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0046628 name: positive regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "activation of insulin receptor signaling pathway" NARROW [] synonym: "positive regulation of insulin receptor signalling pathway" EXACT [] synonym: "stimulation of insulin receptor signaling pathway" NARROW [] synonym: "up regulation of insulin receptor signaling pathway" EXACT [] synonym: "up-regulation of insulin receptor signaling pathway" EXACT [] synonym: "upregulation of insulin receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0046626 ! regulation of insulin receptor signaling pathway relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0046629 name: gamma-delta T cell activation namespace: biological_process def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] synonym: "gamma-delta T lymphocyte activation" EXACT [] synonym: "gamma-delta T-cell activation" EXACT [] synonym: "gamma-delta T-lymphocyte activation" EXACT [] is_a: GO:0042110 ! T cell activation [Term] id: GO:0046630 name: gamma-delta T cell proliferation namespace: biological_process def: "The expansion of a gamma-delta T cell population by cell division." [GOC:ai] synonym: "gamma-delta T lymphocyte proliferation" EXACT [] synonym: "gamma-delta T-cell proliferation" EXACT [] synonym: "gamma-delta T-lymphocyte proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0046631 name: alpha-beta T cell activation namespace: biological_process def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] synonym: "alpha-beta T lymphocyte activation" EXACT [] synonym: "alpha-beta T-cell activation" EXACT [] synonym: "alpha-beta T-lymphocyte activation" EXACT [] is_a: GO:0042110 ! T cell activation [Term] id: GO:0046632 name: alpha-beta T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex." [CL:0000789, GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta T cell development" RELATED [GOC:add] synonym: "alpha-beta T lymphocyte differentiation" EXACT [] synonym: "alpha-beta T-cell differentiation" EXACT [] synonym: "alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046633 name: alpha-beta T cell proliferation namespace: biological_process def: "The expansion of an alpha-beta T cell population by cell division." [GOC:ai] synonym: "alpha-beta T lymphocyte proliferation" EXACT [] synonym: "alpha-beta T-cell proliferation" EXACT [] synonym: "alpha-beta T-lymphocyte proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046634 name: regulation of alpha-beta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] synonym: "regulation of alpha-beta T lymphocyte activation" EXACT [] synonym: "regulation of alpha-beta T-cell activation" EXACT [] synonym: "regulation of alpha-beta T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation relationship: regulates GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046635 name: positive regulation of alpha-beta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] synonym: "activation of alpha-beta T cell activation" NARROW [] synonym: "positive regulation of alpha-beta T lymphocyte activation" EXACT [] synonym: "positive regulation of alpha-beta T-cell activation" EXACT [] synonym: "positive regulation of alpha-beta T-lymphocyte activation" EXACT [] synonym: "stimulation of alpha-beta T cell activation" NARROW [] synonym: "up regulation of alpha-beta T cell activation" EXACT [] synonym: "up-regulation of alpha-beta T cell activation" EXACT [] synonym: "upregulation of alpha-beta T cell activation" EXACT [] is_a: GO:0046634 ! regulation of alpha-beta T cell activation is_a: GO:0050870 ! positive regulation of T cell activation relationship: positively_regulates GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046636 name: negative regulation of alpha-beta T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] synonym: "down regulation of alpha-beta T cell activation" EXACT [] synonym: "down-regulation of alpha-beta T cell activation" EXACT [] synonym: "downregulation of alpha-beta T cell activation" EXACT [] synonym: "inhibition of alpha-beta T cell activation" NARROW [] synonym: "negative regulation of alpha-beta T lymphocyte activation" EXACT [] synonym: "negative regulation of alpha-beta T-cell activation" EXACT [] synonym: "negative regulation of alpha-beta T-lymphocyte activation" EXACT [] is_a: GO:0046634 ! regulation of alpha-beta T cell activation is_a: GO:0050868 ! negative regulation of T cell activation relationship: negatively_regulates GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046637 name: regulation of alpha-beta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of alpha-beta T cell development" RELATED [GOC:add] synonym: "regulation of alpha-beta T lymphocyte differentiation" EXACT [] synonym: "regulation of alpha-beta T-cell differentiation" EXACT [] synonym: "regulation of alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0046634 ! regulation of alpha-beta T cell activation relationship: regulates GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0046638 name: positive regulation of alpha-beta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of alpha-beta T cell differentiation" NARROW [] synonym: "positive regulation of alpha-beta T cell development" RELATED [GOC:add] synonym: "positive regulation of alpha-beta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of alpha-beta T-cell differentiation" EXACT [] synonym: "positive regulation of alpha-beta T-lymphocyte differentiation" EXACT [] synonym: "stimulation of alpha-beta T cell differentiation" NARROW [] synonym: "up regulation of alpha-beta T cell differentiation" EXACT [] synonym: "up-regulation of alpha-beta T cell differentiation" EXACT [] synonym: "upregulation of alpha-beta T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation relationship: positively_regulates GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0046639 name: negative regulation of alpha-beta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of alpha-beta T cell differentiation" EXACT [] synonym: "down-regulation of alpha-beta T cell differentiation" EXACT [] synonym: "downregulation of alpha-beta T cell differentiation" EXACT [] synonym: "inhibition of alpha-beta T cell differentiation" NARROW [] synonym: "negative regulation of alpha-beta T cell development" RELATED [GOC:add] synonym: "negative regulation of alpha-beta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of alpha-beta T-cell differentiation" EXACT [] synonym: "negative regulation of alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation relationship: negatively_regulates GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0046640 name: regulation of alpha-beta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] synonym: "regulation of alpha-beta T lymphocyte proliferation" EXACT [] synonym: "regulation of alpha-beta T-cell proliferation" EXACT [] synonym: "regulation of alpha-beta T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0046634 ! regulation of alpha-beta T cell activation relationship: regulates GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0046641 name: positive regulation of alpha-beta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] synonym: "activation of alpha-beta T cell proliferation" NARROW [] synonym: "positive regulation of alpha-beta T lymphocyte proliferation" EXACT [] synonym: "positive regulation of alpha-beta T-cell proliferation" EXACT [] synonym: "positive regulation of alpha-beta T-lymphocyte proliferation" EXACT [] synonym: "stimulation of alpha-beta T cell proliferation" NARROW [] synonym: "up regulation of alpha-beta T cell proliferation" EXACT [] synonym: "up-regulation of alpha-beta T cell proliferation" EXACT [] synonym: "upregulation of alpha-beta T cell proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation relationship: positively_regulates GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0046642 name: negative regulation of alpha-beta T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] synonym: "down regulation of alpha-beta T cell proliferation" EXACT [] synonym: "down-regulation of alpha-beta T cell proliferation" EXACT [] synonym: "downregulation of alpha-beta T cell proliferation" EXACT [] synonym: "inhibition of alpha-beta T cell proliferation" NARROW [] synonym: "negative regulation of alpha-beta T lymphocyte proliferation" EXACT [] synonym: "negative regulation of alpha-beta T-cell proliferation" EXACT [] synonym: "negative regulation of alpha-beta T-lymphocyte proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation relationship: negatively_regulates GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0046643 name: regulation of gamma-delta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] synonym: "regulation of gamma-delta T lymphocyte activation" EXACT [] synonym: "regulation of gamma-delta T-cell activation" EXACT [] synonym: "regulation of gamma-delta T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation relationship: regulates GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0046644 name: negative regulation of gamma-delta T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] synonym: "down regulation of gamma-delta T cell activation" EXACT [] synonym: "down-regulation of gamma-delta T cell activation" EXACT [] synonym: "downregulation of gamma-delta T cell activation" EXACT [] synonym: "inhibition of gamma-delta T cell activation" NARROW [] synonym: "negative regulation of gamma-delta T lymphocyte activation" EXACT [] synonym: "negative regulation of gamma-delta T-cell activation" EXACT [] synonym: "negative regulation of gamma-delta T-lymphocyte activation" EXACT [] is_a: GO:0046643 ! regulation of gamma-delta T cell activation is_a: GO:0050868 ! negative regulation of T cell activation relationship: negatively_regulates GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0046645 name: positive regulation of gamma-delta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] synonym: "activation of gamma-delta T cell activation" NARROW [] synonym: "positive regulation of gamma-delta T lymphocyte activation" EXACT [] synonym: "positive regulation of gamma-delta T-cell activation" EXACT [] synonym: "positive regulation of gamma-delta T-lymphocyte activation" EXACT [] synonym: "stimulation of gamma-delta T cell activation" NARROW [] synonym: "up regulation of gamma-delta T cell activation" EXACT [] synonym: "up-regulation of gamma-delta T cell activation" EXACT [] synonym: "upregulation of gamma-delta T cell activation" EXACT [] is_a: GO:0046643 ! regulation of gamma-delta T cell activation is_a: GO:0050870 ! positive regulation of T cell activation relationship: positively_regulates GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0046646 name: regulation of gamma-delta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] synonym: "regulation of gamma-delta T lymphocyte proliferation" EXACT [] synonym: "regulation of gamma-delta T-cell proliferation" EXACT [] synonym: "regulation of gamma-delta T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0046643 ! regulation of gamma-delta T cell activation relationship: regulates GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0046647 name: negative regulation of gamma-delta T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] synonym: "down regulation of gamma-delta T cell proliferation" EXACT [] synonym: "down-regulation of gamma-delta T cell proliferation" EXACT [] synonym: "downregulation of gamma-delta T cell proliferation" EXACT [] synonym: "inhibition of gamma-delta T cell proliferation" NARROW [] synonym: "negative regulation of gamma-delta T lymphocyte proliferation" EXACT [] synonym: "negative regulation of gamma-delta T-cell proliferation" EXACT [] synonym: "negative regulation of gamma-delta T-lymphocyte proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation relationship: negatively_regulates GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0046648 name: positive regulation of gamma-delta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] synonym: "activation of gamma-delta T cell proliferation" NARROW [] synonym: "positive regulation of gamma-delta T lymphocyte proliferation" EXACT [] synonym: "positive regulation of gamma-delta T-cell proliferation" EXACT [] synonym: "positive regulation of gamma-delta T-lymphocyte proliferation" EXACT [] synonym: "stimulation of gamma-delta T cell proliferation" NARROW [] synonym: "up regulation of gamma-delta T cell proliferation" EXACT [] synonym: "up-regulation of gamma-delta T cell proliferation" EXACT [] synonym: "upregulation of gamma-delta T cell proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation relationship: positively_regulates GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0046649 name: lymphocyte activation namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0046651 name: lymphocyte proliferation namespace: biological_process def: "The expansion of a lymphocyte population by cell division." [GOC:ai] is_a: GO:0032943 ! mononuclear cell proliferation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0046653 name: tetrahydrofolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "tetrahydrofolate metabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process [Term] id: GO:0046654 name: tetrahydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "tetrahydrofolate anabolism" EXACT [] synonym: "tetrahydrofolate biosynthesis" EXACT [] synonym: "tetrahydrofolate formation" EXACT [] synonym: "tetrahydrofolate synthesis" EXACT [] xref: MetaCyc:FOLSYN-PWY is_a: GO:0009396 ! folic acid-containing compound biosynthetic process is_a: GO:0046653 ! tetrahydrofolate metabolic process [Term] id: GO:0046655 name: folic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "folate metabolic process" EXACT [] synonym: "folate metabolism" EXACT [] synonym: "folic acid metabolism" EXACT [] synonym: "vitamin B9 metabolic process" EXACT [] synonym: "vitamin B9 metabolism" EXACT [] synonym: "vitamin M metabolic process" EXACT [] synonym: "vitamin M metabolism" EXACT [] xref: Reactome:1253510 "Metabolism of folate and pterines" xref: Reactome:1280449 "Metabolism of folate and pterines" xref: Reactome:1299283 "Metabolism of folate and pterines" xref: Reactome:1327027 "Metabolism of folate and pterines" xref: Reactome:1353121 "Metabolism of folate and pterines" xref: Reactome:1373310 "Metabolism of folate and pterines" xref: Reactome:1393323 "Metabolism of folate and pterines" xref: Reactome:1417821 "Metabolism of folate and pterines" xref: Reactome:1450919 "Metabolism of folate and pterines" xref: Reactome:1471299 "Metabolism of folate and pterines" xref: Reactome:1483272 "Metabolism of folate and pterines" xref: Reactome:1496945 "Metabolism of folate and pterines" xref: Reactome:1514332 "Metabolism of folate and pterines" xref: Reactome:1521200 "Metabolism of folate and pterines" xref: Reactome:1526945 "Metabolism of folate and pterines" xref: Reactome:1532683 "Metabolism of folate and pterines" xref: Reactome:1536096 "Metabolism of folate and pterines" xref: Reactome:1538065 "Metabolism of folate and pterines" xref: Reactome:1539346 "Metabolism of folate and pterines" xref: Reactome:1540348 "Metabolism of folate and pterines" xref: Reactome:196757 "Metabolism of folate and pterines" is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process [Term] id: GO:0046656 name: folic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid." [GOC:ai] subset: gosubset_prok synonym: "folate biosynthesis" EXACT [] synonym: "folate biosynthetic process" EXACT [] synonym: "folic acid anabolism" EXACT [] synonym: "folic acid biosynthesis" EXACT [] synonym: "folic acid formation" EXACT [] synonym: "folic acid synthesis" EXACT [] synonym: "vitamin B9 biosynthesis" EXACT [] synonym: "vitamin B9 biosynthetic process" EXACT [] synonym: "vitamin M biosynthesis" EXACT [] synonym: "vitamin M biosynthetic process" EXACT [] xref: MetaCyc:FOLSYN-PWY xref: Wikipedia:Folic_acid is_a: GO:0009396 ! folic acid-containing compound biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046655 ! folic acid metabolic process [Term] id: GO:0046657 name: folic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid." [GOC:ai] subset: gosubset_prok synonym: "folate catabolic process" EXACT [] synonym: "folate catabolism" EXACT [] synonym: "folic acid breakdown" EXACT [] synonym: "folic acid catabolism" EXACT [] synonym: "folic acid degradation" EXACT [] synonym: "vitamin B9 catabolic process" EXACT [] synonym: "vitamin B9 catabolism" EXACT [] synonym: "vitamin M catabolic process" EXACT [] synonym: "vitamin M catabolism" EXACT [] is_a: GO:0009397 ! folic acid-containing compound catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0046655 ! folic acid metabolic process [Term] id: GO:0046658 name: anchored to plasma membrane namespace: cellular_component def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah] synonym: "plasma membrane, GPI-anchored" NARROW [] is_a: GO:0031225 ! anchored to membrane is_a: GO:0031226 ! intrinsic to plasma membrane [Term] id: GO:0046659 name: digestive hormone activity namespace: molecular_function def: "The action characteristic of a hormone that takes part in the digestion process." [GOC:ai] synonym: "secretin" NARROW [] is_a: GO:0005179 ! hormone activity [Term] id: GO:0046660 name: female sex differentiation namespace: biological_process def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] is_a: GO:0007548 ! sex differentiation relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0046661 name: male sex differentiation namespace: biological_process def: "The establishment of the sex of a male organism by physical differentiation." [GOC:bf] is_a: GO:0007548 ! sex differentiation relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0046662 name: regulation of oviposition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai] is_a: GO:0050795 ! regulation of behavior is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0018991 ! oviposition [Term] id: GO:0046663 name: dorsal closure, leading edge cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure." [GOC:ai, PMID:12147138] is_a: GO:0035026 ! leading edge cell differentiation relationship: part_of GO:0007392 ! initiation of dorsal closure [Term] id: GO:0046664 name: dorsal closure, amnioserosa morphology change namespace: biological_process def: "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0046665 name: amnioserosa maintenance namespace: biological_process def: "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf] is_a: GO:0001894 ! tissue homeostasis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0046666 name: retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the developing retina." [GOC:bf] synonym: "programmed cell death, retina cells" EXACT [] synonym: "programmed cell death, retinal cells" EXACT [] synonym: "retina cell programmed cell death" EXACT [] synonym: "retina programmed cell death" EXACT [] synonym: "retinal programmed cell death" EXACT [] is_a: GO:0010623 ! developmental programmed cell death relationship: part_of GO:0048592 ! eye morphogenesis [Term] id: GO:0046667 name: compound eye retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] is_a: GO:0046666 ! retinal cell programmed cell death relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0046668 name: regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0060284 ! regulation of cell development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0046666 ! retinal cell programmed cell death [Term] id: GO:0046669 name: regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046668 ! regulation of retinal cell programmed cell death relationship: regulates GO:0046667 ! compound eye retinal cell programmed cell death [Term] id: GO:0046670 name: positive regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "activation of retinal programmed cell death" NARROW [] synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb] synonym: "stimulation of retinal programmed cell death" NARROW [] synonym: "up regulation of retinal programmed cell death" EXACT [] synonym: "up-regulation of retinal programmed cell death" EXACT [] synonym: "upregulation of retinal programmed cell death" EXACT [] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0046666 ! retinal cell programmed cell death [Term] id: GO:0046671 name: negative regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "down regulation of retinal programmed cell death" EXACT [] synonym: "down-regulation of retinal programmed cell death" EXACT [] synonym: "downregulation of retinal programmed cell death" EXACT [] synonym: "inhibition of retinal programmed cell death" NARROW [] synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0046666 ! retinal cell programmed cell death [Term] id: GO:0046672 name: positive regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "activation of retinal cell programmed cell death" BROAD [] synonym: "positive regulation of retinal cell programmed cell death" BROAD [] synonym: "stimulation of retinal cell programmed cell death" BROAD [] synonym: "up regulation of retinal cell programmed cell death" BROAD [] synonym: "up-regulation of retinal cell programmed cell death" BROAD [] synonym: "upregulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death relationship: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death [Term] id: GO:0046673 name: negative regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "down regulation of retinal cell programmed cell death" BROAD [] synonym: "down-regulation of retinal cell programmed cell death" BROAD [] synonym: "downregulation of retinal cell programmed cell death" BROAD [] synonym: "inhibition of retinal cell programmed cell death" BROAD [] synonym: "negative regulation of retina cell programmed cell death" BROAD [] synonym: "negative regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death relationship: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death [Term] id: GO:0046674 name: induction of retinal programmed cell death namespace: biological_process def: "A process which directly activates any of the steps required for programmed cell death in the retina." [GOC:ai] is_a: GO:0012502 ! induction of programmed cell death is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death [Term] id: GO:0046675 name: induction of compound eye retinal cell programmed cell death namespace: biological_process def: "A process that directly activates any of the steps required for programmed cell death in the compound eye retina." [GOC:ai] synonym: "induction of retinal cell programmed cell death" BROAD [] is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death is_a: GO:0046674 ! induction of retinal programmed cell death [Term] id: GO:0046676 name: negative regulation of insulin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai] synonym: "down regulation of insulin secretion" EXACT [] synonym: "down-regulation of insulin secretion" EXACT [] synonym: "downregulation of insulin secretion" EXACT [] synonym: "inhibition of insulin secretion" NARROW [] is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion relationship: negatively_regulates GO:0030073 ! insulin secretion [Term] id: GO:0046677 name: response to antibiotic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef] subset: gosubset_prok synonym: "antibiotic susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0046678 name: response to bacteriocin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "bacteriocin susceptibility/resistance" RELATED [] is_a: GO:0046677 ! response to antibiotic [Term] id: GO:0046679 name: response to streptomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [CHEBI:17076, GOC:curators] synonym: "streptomycin susceptibility/resistance" RELATED [] is_a: GO:0046677 ! response to antibiotic [Term] id: GO:0046680 name: response to DDT namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "DDT resistance" RELATED [] synonym: "DDT susceptibility/resistance" RELATED [] is_a: GO:0017085 ! response to insecticide [Term] id: GO:0046681 name: response to carbamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "carbamate resistance" RELATED [] synonym: "carbamate susceptibility/resistance" RELATED [] is_a: GO:0017085 ! response to insecticide [Term] id: GO:0046682 name: response to cyclodiene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring." [ISBN:0877797099] synonym: "cyclodiene resistance" RELATED [] synonym: "cyclodiene susceptibility/resistance" RELATED [] is_a: GO:0017085 ! response to insecticide [Term] id: GO:0046683 name: response to organophosphorus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "organophosphorus resistance" RELATED [] synonym: "organophosphorus susceptibility/resistance" RELATED [] is_a: GO:0017085 ! response to insecticide [Term] id: GO:0046684 name: response to pyrethroid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "pyrethroid resistance" RELATED [] synonym: "pyrethroid susceptibility/resistance" RELATED [] is_a: GO:0017085 ! response to insecticide [Term] id: GO:0046685 name: response to arsenic-containing substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "arsenate sensitivity/resistance" RELATED [] synonym: "response to arsenic" EXACT [GOC:curators] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0046686 name: response to cadmium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai] subset: gosubset_prok synonym: "cadmium sensitivity/resistance" RELATED [] synonym: "response to cadmium" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0046687 name: response to chromate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "chromate sensitivity/resistance" RELATED [] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0046688 name: response to copper ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai] subset: gosubset_prok synonym: "copper sensitivity/resistance" RELATED [] synonym: "response to copper" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0046689 name: response to mercury ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai] subset: gosubset_prok synonym: "mercuric sensitivity/resistance" RELATED [] synonym: "response to mercuric ion" NARROW [GOC:mah] synonym: "response to mercury" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0046690 name: response to tellurium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:ai] subset: gosubset_prok synonym: "response to tellurium" EXACT [] synonym: "tellurium sensitivity/resistance" RELATED [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0046691 name: intracellular canaliculus namespace: cellular_component def: "An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." [GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:10700045] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0016324 ! apical plasma membrane [Term] id: GO:0046692 name: sperm competition namespace: biological_process def: "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514] xref: Wikipedia:Sperm_competition is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007320 ! insemination [Term] id: GO:0046693 name: sperm storage namespace: biological_process def: "The retention of sperm by a female following mating." [PMID:10885514] synonym: "retention of sperm" EXACT [] synonym: "sequestering of sperm" EXACT [] synonym: "sequestration of sperm" EXACT [] synonym: "sperm retention" EXACT [] synonym: "sperm sequestering" EXACT [] synonym: "sperm sequestration" EXACT [] synonym: "storage of sperm" EXACT [] is_a: GO:0046692 ! sperm competition [Term] id: GO:0046694 name: sperm incapacitation namespace: biological_process def: "The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males." [PMID:10440373] is_a: GO:0046692 ! sperm competition [Term] id: GO:0046695 name: SLIK (SAGA-like) complex namespace: cellular_component def: "A SAGA-type histone acetyltransferase complex that contains Rtg2 and a smaller form of Spt7 than the fungal SAGA complex, and lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction." [PMID:12101232, PMID:12186975, PMID:17337012] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "SAGA (alt) complex" EXACT [] synonym: "SALSA complex" EXACT [] synonym: "SLIK/SALSA complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0046696 name: lipopolysaccharide receptor complex namespace: cellular_component def: "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated." [PMID:11706042] comment: Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of. synonym: "LPS receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0016021 ! integral to membrane [Term] id: GO:0046697 name: decidualization namespace: biological_process def: "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:11133685] synonym: "decidual cell reaction" EXACT [] xref: Wikipedia:Decidualization is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009888 ! tissue development relationship: part_of GO:0001893 ! maternal placenta development relationship: part_of GO:0007565 ! female pregnancy [Term] id: GO:0046700 name: heterocycle catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai] subset: gosubset_prok synonym: "heterocycle breakdown" EXACT [] synonym: "heterocycle catabolism" EXACT [] synonym: "heterocycle degradation" EXACT [] is_a: GO:0044248 ! cellular catabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046701 name: insecticide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai] subset: gosubset_prok synonym: "insecticide breakdown" EXACT [] synonym: "insecticide catabolism" EXACT [] synonym: "insecticide degradation" EXACT [] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0046702 name: galactoside 6-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside." [PMID:12413479] is_a: GO:0046921 ! alpha(1,6)-fucosyltransferase activity [Term] id: GO:0046703 name: natural killer cell lectin-like receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lectin-like natural killer cell receptor." [GOC:ai] synonym: "KLRC4 receptor binding" NARROW [] synonym: "NK cell lectin-like receptor binding" EXACT [] synonym: "NKG2D receptor binding" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0046704 name: CDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate." [GOC:ai] subset: gosubset_prok synonym: "CDP metabolism" EXACT [] is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process [Term] id: GO:0046705 name: CDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai] subset: gosubset_prok synonym: "CDP anabolism" EXACT [] synonym: "CDP biosynthesis" EXACT [] synonym: "CDP formation" EXACT [] synonym: "CDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0046704 ! CDP metabolic process [Term] id: GO:0046706 name: CDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate." [GOC:ai] subset: gosubset_prok synonym: "CDP breakdown" EXACT [] synonym: "CDP catabolism" EXACT [] synonym: "CDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0046704 ! CDP metabolic process [Term] id: GO:0046707 name: IDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving IDP, inosine 5'-diphosphate." [GOC:ai] subset: gosubset_prok synonym: "IDP metabolism" EXACT [] is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process [Term] id: GO:0046708 name: IDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate." [GOC:ai] subset: gosubset_prok synonym: "IDP anabolism" EXACT [] synonym: "IDP biosynthesis" EXACT [] synonym: "IDP formation" EXACT [] synonym: "IDP synthesis" EXACT [] is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process is_a: GO:0046707 ! IDP metabolic process [Term] id: GO:0046709 name: IDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate." [GOC:ai] subset: gosubset_prok synonym: "IDP breakdown" EXACT [] synonym: "IDP catabolism" EXACT [] synonym: "IDP degradation" EXACT [] is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process is_a: GO:0046707 ! IDP metabolic process [Term] id: GO:0046710 name: GDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate." [GOC:ai] subset: gosubset_prok synonym: "GDP metabolism" EXACT [] is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process [Term] id: GO:0046711 name: GDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate." [GOC:ai] subset: gosubset_prok synonym: "GDP anabolism" EXACT [] synonym: "GDP biosynthesis" EXACT [] synonym: "GDP formation" EXACT [] synonym: "GDP synthesis" EXACT [] is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process is_a: GO:0046710 ! GDP metabolic process [Term] id: GO:0046712 name: GDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate." [GOC:ai] subset: gosubset_prok synonym: "GDP breakdown" EXACT [] synonym: "GDP catabolism" EXACT [] synonym: "GDP degradation" EXACT [] is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process is_a: GO:0046710 ! GDP metabolic process [Term] id: GO:0046713 name: borate transport namespace: biological_process def: "The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [CHEBI:22908, GOC:curators, http://www.webelements.com/] synonym: "boron transport" RELATED [GOC:curators] is_a: GO:0006820 ! anion transport [Term] id: GO:0046714 name: borate binding namespace: molecular_function def: "Interacting selectively and non-covalently with borate, the anion (BO3)3-." [CHEBI:22908, GOC:curators] subset: gosubset_prok synonym: "boron binding" RELATED [GOC:curators] is_a: GO:0043168 ! anion binding [Term] id: GO:0046715 name: borate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transport of borate across a membrane against the concentration gradient." [PMID:12447444] subset: gosubset_prok synonym: "boron transmembrane transporter activity" RELATED [GOC:curators] synonym: "efflux-type borate transporter" NARROW [GOC:curators] synonym: "efflux-type boron transporter" RELATED [GOC:curators] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0046716 name: muscle cell homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb] synonym: "muscle homeostasis" RELATED [GOC:dph] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0046717 name: acid secretion namespace: biological_process def: "The controlled release of acid by a cell or group of cells." [GOC:ai] is_a: GO:0046903 ! secretion [Term] id: GO:0046718 name: entry of virus into host cell namespace: biological_process def: "The process in which a virion enters a host cell, including virion attachment and penetration." [ISBN:0781718325] synonym: "viral entry into host cell" EXACT [] xref: Reactome:168270 "Fusion and Uncoating of the Influenza Virion" xref: Reactome:168272 "Binding of the influenza virion to the host cell" is_a: GO:0030260 ! entry into host cell relationship: part_of GO:0019059 ! initiation of viral infection [Term] id: GO:0046719 name: regulation of viral protein levels in host cell namespace: biological_process def: "Any virus-mediated process that modulates the levels of viral proteins in a cell." [GOC:ai] synonym: "regulation of viral protein levels" EXACT [] is_a: GO:0019048 ! virus-host interaction is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0046720 name: citric acid secretion namespace: biological_process def: "The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or group of cells." [GOC:ai] synonym: "citrate secretion" EXACT [] is_a: GO:0015746 ! citrate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046721 name: formic acid secretion namespace: biological_process def: "The controlled release of formic acid, HCOOH, by a cell or group of cells." [GOC:ai] synonym: "formate secretion" EXACT [] is_a: GO:0015724 ! formate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046722 name: lactic acid secretion namespace: biological_process def: "The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or group of cells." [GOC:ai] synonym: "lactate secretion" EXACT [] is_a: GO:0035879 ! plasma membrane lactate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046723 name: malic acid secretion namespace: biological_process def: "The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or group of cells." [GOC:ai] synonym: "hydroxysuccinic acid secretion" EXACT [] synonym: "malate secretion" EXACT [] is_a: GO:0015743 ! malate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046724 name: oxalic acid secretion namespace: biological_process def: "The controlled release of oxalic acid, ethanedioic acid, by a cell or group of cells." [GOC:ai] synonym: "oxalate secretion" EXACT [] is_a: GO:0019532 ! oxalate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046725 name: negative regulation of viral protein levels in host cell namespace: biological_process def: "Any process that reduces the levels of viral proteins in a cell." [GOC:ai] synonym: "down regulation of viral protein levels in host cell" EXACT [] synonym: "down-regulation of viral protein levels in host cell" EXACT [] synonym: "downregulation of viral protein levels in host cell" EXACT [] synonym: "inhibition of viral protein levels in host cell" NARROW [] synonym: "negative regulation of viral protein levels" EXACT [] is_a: GO:0046719 ! regulation of viral protein levels in host cell is_a: GO:0048519 ! negative regulation of biological process [Term] id: GO:0046726 name: positive regulation of viral protein levels in host cell namespace: biological_process def: "Any process that increases the levels of viral proteins in a cell." [GOC:ai] synonym: "activation of viral protein levels in host cell" NARROW [] synonym: "positive regulation of viral protein levels" EXACT [] synonym: "stimulation of viral protein levels in host cell" NARROW [] synonym: "up regulation of viral protein levels in host cell" EXACT [] synonym: "up-regulation of viral protein levels in host cell" EXACT [] synonym: "upregulation of viral protein levels in host cell" EXACT [] is_a: GO:0046719 ! regulation of viral protein levels in host cell is_a: GO:0048518 ! positive regulation of biological process [Term] id: GO:0046727 name: capsomere namespace: cellular_component def: "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "capsomer" EXACT [] xref: Wikipedia:Capsomere is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0046729 name: viral procapsid namespace: cellular_component def: "A stable empty viral capsid produced during the assembly of viruses." [ISBN:0072370319, ISBN:1555811272] is_a: GO:0044423 ! virion part [Term] id: GO:0046730 name: induction of host immune response by virus namespace: biological_process def: "The induction by a virus of an immune response in the host organism." [ISBN:0781802976] synonym: "activation of host immune response by virus" EXACT [] is_a: GO:0019048 ! virus-host interaction is_a: GO:0044416 ! induction by symbiont of host defense response [Term] id: GO:0046731 name: passive induction of host immune response by virus namespace: biological_process def: "The unintentional stimulation by a virus of a host defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976] synonym: "passive activation of host immune response by virus" EXACT [] synonym: "passive viral induction of host immune response" EXACT [] is_a: GO:0046730 ! induction of host immune response by virus [Term] id: GO:0046732 name: active induction of host immune response by virus namespace: biological_process def: "The intentional, virally-encoded stimulation of a host defense response to viral infection." [ISBN:0781802976] synonym: "active viral induction of host immune response" EXACT [] xref: Reactome:168277 "Influenza Virus Induced Apoptosis" xref: Reactome:168865 "NA activation of TGF-beta" xref: Reactome:168878 "PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis" is_a: GO:0046730 ! induction of host immune response by virus [Term] id: GO:0046733 name: passive induction of host humoral immune response by virus namespace: biological_process def: "The unintentional stimulation by a virus of a host humoral defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976] synonym: "passive induction of humoral immune response in host by virus" EXACT [] synonym: "passive viral activation of humoral immune response in host" EXACT [] synonym: "passive viral induction of humoral immune response in host" EXACT [] is_a: GO:0046731 ! passive induction of host immune response by virus [Term] id: GO:0046734 name: passive induction of host cell-mediated immune response by virus namespace: biological_process def: "The unintentional stimulation by a virus of a cell-mediated host defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976] synonym: "passive induction of cell-mediated immune response in host by virus" EXACT [] synonym: "passive viral activation of cell-mediated immune response in host" EXACT [] synonym: "passive viral induction of cell-mediated immune response in host" EXACT [] is_a: GO:0046731 ! passive induction of host immune response by virus [Term] id: GO:0046735 name: passive induction of host innate immune response by virus namespace: biological_process def: "The unintentional stimulation by a virus of an innate host defense response to viral infection, as part of the viral infectious cycle." [GOC:go_curators, ISBN:0781802976] synonym: "passive induction of innate immune response in host by virus" EXACT [] synonym: "passive viral activation of innate immune response in host" EXACT [] synonym: "passive viral induction of innate immune response in host" EXACT [] is_a: GO:0046731 ! passive induction of host immune response by virus [Term] id: GO:0046736 name: active induction of humoral immune response in host by virus namespace: biological_process def: "The intentional, virally-encoded stimulation of a host humoral defense response to viral infection." [ISBN:0781802976] synonym: "active viral induction of humoral immune response in host" EXACT [] is_a: GO:0046732 ! active induction of host immune response by virus [Term] id: GO:0046737 name: active induction of cell-mediated immune response in host by virus namespace: biological_process def: "The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection." [ISBN:0781802976] synonym: "active viral induction of cell-mediated immune response in host" EXACT [] is_a: GO:0046732 ! active induction of host immune response by virus [Term] id: GO:0046738 name: active induction of innate immune response in host by virus namespace: biological_process def: "The intentional, virally-encoded stimulation of an innate host defense response to viral infection." [ISBN:0781802976] synonym: "active viral induction of innate immune response in host" EXACT [] is_a: GO:0046732 ! active induction of host immune response by virus [Term] id: GO:0046739 name: spread of virus in host namespace: biological_process def: "The dissemination of infectious virion particles within an infected host organism." [ISBN:0781718325] synonym: "spread of virus within host" EXACT [] synonym: "viral spread within host" EXACT [] is_a: GO:0019048 ! virus-host interaction is_a: GO:0044000 ! movement in host [Term] id: GO:0046740 name: spread of virus in host, cell to cell namespace: biological_process def: "The process of viral dissemination within an infected host organism where infectious virion particles are passed from infected to uninfected host cells." [ISBN:0781718325] synonym: "cell to cell spread of virus within host" EXACT [] synonym: "spread of virus within host, cell to cell" EXACT [] synonym: "viral spread within host, cell to cell" EXACT [] is_a: GO:0046739 ! spread of virus in host [Term] id: GO:0046741 name: spread of virus in host, tissue to tissue namespace: biological_process def: "The process of viral dissemination within an infected host organism where infectious virion particles are passed from infected to uninfected host tissue." [ISBN:0781718325] synonym: "spread of virus within host, tissue to tissue" EXACT [] synonym: "tissue to tissue spread of virus within host" EXACT [] synonym: "viral spread within host, tissue to tissue" EXACT [] is_a: GO:0046739 ! spread of virus in host [Term] id: GO:0046742 name: viral capsid transport in host cell nucleus namespace: biological_process def: "The directed movement of viral capsid proteins within the nucleus of the host cell." [ISBN:0781718325] synonym: "nuclear viral capsid transport" EXACT [] is_a: GO:0046801 ! intracellular transport of viral capsid in host cell [Term] id: GO:0046743 name: viral capsid transport in host cell cytoplasm namespace: biological_process def: "The directed movement of viral capsid proteins within the cytoplasm of the host cell." [ISBN:0781718325, PMID:11581394] synonym: "cytoplasmic viral capsid transport" EXACT [] is_a: GO:0016482 ! cytoplasmic transport is_a: GO:0046801 ! intracellular transport of viral capsid in host cell [Term] id: GO:0046744 name: viral capsid envelopment namespace: biological_process def: "The process in which a capsid acquires a membrane envelope." [ISBN:0781718325] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019069 ! viral capsid assembly [Term] id: GO:0046745 name: viral capsid re-envelopment namespace: biological_process def: "The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope." [ISBN:0781718325] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019069 ! viral capsid assembly [Term] id: GO:0046746 name: virus budding from nuclear membrane by viral capsid re-envelopment namespace: biological_process def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host nuclear membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] synonym: "nuclear membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "viral budding from nuclear membrane during viral capsid re-envelopment" RELATED [] synonym: "virus budding from nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb] is_a: GO:0046745 ! viral capsid re-envelopment is_a: GO:0046765 ! virus budding from nuclear membrane [Term] id: GO:0046747 name: virus budding from Golgi membrane by viral capsid re-envelopment namespace: biological_process def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host Golgi membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] synonym: "Golgi membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "viral budding from Golgi membrane during viral capsid re-envelopment" RELATED [] synonym: "virus budding from Golgi membrane during viral capsid re-envelopment" RELATED [GOC:tb] is_a: GO:0046745 ! viral capsid re-envelopment is_a: GO:0046763 ! virus budding from Golgi membrane [Term] id: GO:0046748 name: virus budding from ER membrane by viral capsid re-envelopment namespace: biological_process def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] synonym: "endoplasmic reticulum membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "ER membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "viral budding from ER membrane during viral capsid re-envelopment" RELATED [] synonym: "virus budding from ER membrane during viral capsid re-envelopment" RELATED [GOC:tb] is_a: GO:0046745 ! viral capsid re-envelopment is_a: GO:0046764 ! virus budding from ER membrane [Term] id: GO:0046749 name: virus budding from nuclear membrane by viral capsid envelopment namespace: biological_process def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] synonym: "nuclear membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from nuclear membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from nuclear membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046744 ! viral capsid envelopment is_a: GO:0046765 ! virus budding from nuclear membrane [Term] id: GO:0046750 name: virus budding from Golgi membrane by viral capsid envelopment namespace: biological_process def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host Golgi membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] synonym: "Golgi membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from Golgi membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from Golgi membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046744 ! viral capsid envelopment is_a: GO:0046763 ! virus budding from Golgi membrane [Term] id: GO:0046751 name: virus budding from ER membrane by viral capsid envelopment namespace: biological_process def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] synonym: "endoplasmic reticulum membrane viral budding during viral capsid envelopment" RELATED [] synonym: "ER membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from ER membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from ER membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046744 ! viral capsid envelopment is_a: GO:0046764 ! virus budding from ER membrane [Term] id: GO:0046752 name: viral capsid precursor localization in host cell nucleus namespace: biological_process def: "Any process in which viral capsid precursors are transported to, or maintained in, a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid." [ISBN:0781718325] synonym: "establishment and maintenance of viral capsid precursor localization in nucleus" EXACT [] synonym: "localization of viral capsid precursors in nucleus" EXACT [] synonym: "nuclear localization of viral capsid precursors" EXACT [] synonym: "viral capsid precursor localisation in host cell nucleus" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019069 ! viral capsid assembly relationship: part_of GO:0046719 ! regulation of viral protein levels in host cell [Term] id: GO:0046753 name: non-lytic viral release namespace: biological_process def: "The release of virion particles from the cell that does not result in cell lysis." [ISBN:0072370319] is_a: GO:0019076 ! release of virus from host [Term] id: GO:0046754 name: non-lytic viral exocytosis namespace: biological_process def: "The exit of the virion particle from the host cell by exocytosis, without causing cell lysis." [ISBN:0072370319] is_a: GO:0046753 ! non-lytic viral release [Term] id: GO:0046755 name: non-lytic virus budding namespace: biological_process def: "A form of viral release in which the viral particles bud out through cellular membranes without causing cell lysis. It is also a form of viral envelopment." [ISBN:0072370319] synonym: "non-lytic viral budding" EXACT [] is_a: GO:0046753 ! non-lytic viral release [Term] id: GO:0046756 name: lytic viral exocytosis namespace: biological_process def: "The exit of the virion particle from the host cell by exocytosis, resulting in cell lysis." [ISBN:0072370319] is_a: GO:0019077 ! lytic viral release [Term] id: GO:0046757 name: lytic virus budding from ER membrane namespace: biological_process def: "A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] synonym: "lytic endoplasmic reticulum membrane viral budding" EXACT [] synonym: "lytic ER membrane viral budding" EXACT [] synonym: "lytic viral budding from ER membrane" EXACT [] is_a: GO:0019078 ! lytic viral budding is_a: GO:0046764 ! virus budding from ER membrane [Term] id: GO:0046758 name: lytic virus budding from Golgi membrane namespace: biological_process def: "A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] synonym: "lytic Golgi membrane viral budding" EXACT [] synonym: "lytic viral budding from Golgi membrane" EXACT [] is_a: GO:0019078 ! lytic viral budding is_a: GO:0046763 ! virus budding from Golgi membrane [Term] id: GO:0046759 name: lytic virus budding from plasma membrane namespace: biological_process def: "A form of viral release in which the nucleocapsid evaginates from the host nuclear membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] synonym: "lytic plasma membrane viral budding" EXACT [] synonym: "lytic viral budding from plasma membrane" EXACT [] is_a: GO:0019078 ! lytic viral budding is_a: GO:0046766 ! virus budding from plasma membrane [Term] id: GO:0046760 name: non-lytic virus budding from Golgi membrane namespace: biological_process def: "A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus without triggering cell lysis." [ISBN:0072370319] synonym: "non-lytic Golgi membrane viral budding" EXACT [] synonym: "non-lytic viral budding from Golgi membrane" EXACT [] is_a: GO:0046755 ! non-lytic virus budding is_a: GO:0046763 ! virus budding from Golgi membrane [Term] id: GO:0046761 name: non-lytic virus budding from plasma membrane namespace: biological_process def: "A form of viral release in which the nucleocapsid evaginates from the host plasma membrane system, resulting in envelopment of the virus without triggering cell lysis." [ISBN:0072370319] synonym: "non-lytic plasma membrane viral budding" EXACT [] synonym: "non-lytic viral budding from plasma membrane" EXACT [] is_a: GO:0046755 ! non-lytic virus budding is_a: GO:0046766 ! virus budding from plasma membrane [Term] id: GO:0046762 name: non-lytic virus budding from ER membrane namespace: biological_process def: "A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus without triggering cell lysis." [ISBN:0072370319] synonym: "non-lytic endoplasmic reticulum membrane viral budding" EXACT [] synonym: "non-lytic ER membrane viral budding" EXACT [] synonym: "non-lytic viral budding from ER membrane" EXACT [] is_a: GO:0046755 ! non-lytic virus budding is_a: GO:0046764 ! virus budding from ER membrane [Term] id: GO:0046763 name: virus budding from Golgi membrane namespace: biological_process def: "The evagination of the nucleocapsid from the host Golgi membrane system, resulting in envelopment of the virus." [ISBN:0072370319] synonym: "Golgi membrane viral budding" EXACT [] synonym: "viral budding from Golgi membrane" EXACT [] is_a: GO:0019067 ! viral assembly, maturation, egress, and release [Term] id: GO:0046764 name: virus budding from ER membrane namespace: biological_process def: "The evagination of the nucleocapsid from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus." [ISBN:0072370319] synonym: "endoplasmic reticulum membrane viral budding" EXACT [] synonym: "ER membrane viral budding" EXACT [] synonym: "viral budding from ER membrane" EXACT [] is_a: GO:0019067 ! viral assembly, maturation, egress, and release [Term] id: GO:0046765 name: virus budding from nuclear membrane namespace: biological_process def: "The evagination of the nucleocapsid from the host nuclear membrane system, resulting in envelopment of the virus." [ISBN:0072370319] synonym: "nuclear membrane viral budding" EXACT [] synonym: "viral budding from nuclear membrane" EXACT [] is_a: GO:0019067 ! viral assembly, maturation, egress, and release [Term] id: GO:0046766 name: virus budding from plasma membrane namespace: biological_process def: "The evagination of the nucleocapsid from the host plasma membrane system, resulting in envelopment of the virus." [ISBN:0072370319] synonym: "plasma membrane viral budding" EXACT [] synonym: "viral budding from plasma membrane" EXACT [] xref: Reactome:168860 "Membrane fusion" is_a: GO:0019067 ! viral assembly, maturation, egress, and release [Term] id: GO:0046767 name: virus budding from plasma membrane by viral capsid envelopment namespace: biological_process def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host plasma membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] synonym: "plasma membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from plasma membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from plasma membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046744 ! viral capsid envelopment is_a: GO:0046766 ! virus budding from plasma membrane [Term] id: GO:0046768 name: virus budding from plasma membrane by viral capsid re-envelopment namespace: biological_process def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host plasma membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] synonym: "plasma membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "viral budding from plasma membrane during viral capsid re-envelopment" RELATED [] synonym: "virus budding from plasma membrane during viral capsid re-envelopment" RELATED [GOC:tb] is_a: GO:0046745 ! viral capsid re-envelopment is_a: GO:0046766 ! virus budding from plasma membrane [Term] id: GO:0046769 name: virus budding from inner nuclear membrane by viral capsid re-envelopment namespace: biological_process def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] synonym: "inner nuclear membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "viral budding from inner nuclear membrane during viral capsid re-envelopment" RELATED [] synonym: "virus budding from inner nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb] is_a: GO:0046746 ! virus budding from nuclear membrane by viral capsid re-envelopment [Term] id: GO:0046770 name: virus budding from outer nuclear membrane by viral capsid re-envelopment namespace: biological_process def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] synonym: "outer nuclear membrane viral budding during viral capsid re-envelopment" EXACT [] synonym: "viral budding from outer nuclear membrane during viral capsid re-envelopment" EXACT [] synonym: "virus budding from outer nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb] is_a: GO:0046746 ! virus budding from nuclear membrane by viral capsid re-envelopment [Term] id: GO:0046771 name: virus budding from inner nuclear membrane by viral capsid envelopment namespace: biological_process def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] synonym: "inner nuclear membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from inner nuclear membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from inner nuclear membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046749 ! virus budding from nuclear membrane by viral capsid envelopment [Term] id: GO:0046772 name: virus budding from outer nuclear membrane by viral capsid envelopment namespace: biological_process def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] synonym: "outer nuclear membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from outer nuclear membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from outer nuclear membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046749 ! virus budding from nuclear membrane by viral capsid envelopment [Term] id: GO:0046773 name: suppression by virus of host termination of protein biosynthetic process namespace: biological_process def: "Any viral process that inhibits the termination of host cell protein biosynthesis that occurs in response to viral infection." [ISBN:0781718325] synonym: "negative regulation by virus of host cell protein biosynthesis shutoff" EXACT [] synonym: "negative regulation by virus of host cell protein biosynthetic process shutoff" EXACT [] synonym: "viral inhibition of host cell protein biosynthesis shutoff" EXACT [] synonym: "viral inhibition of host cell protein biosynthetic process shutoff" EXACT [] synonym: "viral inhibition of termination of host cell protein biosynthesis" EXACT [] synonym: "viral inhibition of termination of host cell protein biosynthetic process" EXACT [] synonym: "viral suppression of termination by host of host cell protein biosynthesis" EXACT [] synonym: "viral suppression of termination by host of host cell protein biosynthetic process" EXACT [] is_a: GO:0019049 ! evasion of host defenses by virus is_a: GO:0019054 ! modulation by virus of host cellular process [Term] id: GO:0046774 name: suppression by virus of host intracellular interferon activity namespace: biological_process def: "Any viral process that results in the inhibition of interferon activity within the host cell." [PMID:10859382] synonym: "negative regulation by virus of intracellular interferon activity" EXACT [] synonym: "suppression by virus of intracellular interferon activity in host" EXACT [] is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response [Term] id: GO:0046775 name: suppression by virus of host cytokine production namespace: biological_process def: "Any viral process that results in the inhibition of host cell cytokine production." [PMID:10859382] synonym: "negative regulation by virus of host cytokine production" EXACT [] is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0046776 name: suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, GOC:bf, PMID:10859382] synonym: "major histocompatibility complex" RELATED [] synonym: "negative regulation by virus of MHC class I cell surface presentation" EXACT [] synonym: "suppression by virus of host MHC class I cell surface presentation" EXACT [GOC:add] synonym: "suppression by virus of MHC class I cell surface presentation in host" EXACT [] is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response [Term] id: GO:0046777 name: protein autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "protein amino acid autophosphorylation" EXACT [GOC:bf] xref: Reactome:1229652 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1257422 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1283113 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1303483 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1330948 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1355944 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1376911 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1397087 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1423100 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1455411 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1474713 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1487692 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1502370 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1523690 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:1529423 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" xref: Reactome:75147 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes" is_a: GO:0006468 ! protein phosphorylation [Term] id: GO:0046778 name: modification by virus of host mRNA processing namespace: biological_process def: "Any viral process that interferes with the processing of mRNA in the host cell." [ISBN:0781718325] synonym: "viral perturbation of host mRNA processing" EXACT [] xref: Reactome:168315 "Inhibition of Host mRNA Processing and RNA Silencing" xref: Reactome:168859 "Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)" xref: Reactome:168883 "Binding of NS1 to poly(A)-binding protein II (PABII)" is_a: GO:0019056 ! modulation by virus of host transcription [Term] id: GO:0046779 name: suppression by virus of expression of host genes with introns namespace: biological_process def: "Any viral process that discriminates against and subsequently inhibits host transcripts containing introns, thus allowing only intronless viral mRNA to be fully processed." [PMID:11598019] synonym: "negative regulation by virus of expression of host genes with introns" EXACT [] synonym: "viral inhibition of expression of host genes with introns" EXACT [] is_a: GO:0019056 ! modulation by virus of host transcription [Term] id: GO:0046780 name: suppression by virus of host mRNA splicing namespace: biological_process def: "Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production." [ISBN:0781718325] synonym: "negative regulation by virus of host mRNA splicing" EXACT [] synonym: "viral inhibition of host mRNA splicing" EXACT [] is_a: GO:0046778 ! modification by virus of host mRNA processing [Term] id: GO:0046781 name: dispersion by virus of host splicing factors namespace: biological_process def: "Any viral process that disperses host splicing factors (snRNPs) to prevent host mRNA splicing, thus reducing host protein production." [ISBN:0781718325] synonym: "viral dispersion of host splicing factors" EXACT [] is_a: GO:0046778 ! modification by virus of host mRNA processing [Term] id: GO:0046782 name: regulation of viral transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transcription of the viral genome." [GOC:ai] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0050792 ! regulation of viral reproduction is_a: GO:0051252 ! regulation of RNA metabolic process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0019083 ! viral transcription [Term] id: GO:0046783 name: modification by virus of host polysomes namespace: biological_process def: "Any viral process that interferes with and inhibits the assembly and function of polysomes." [PMID:10438802] comment: See also the cellular component term 'polysome ; GO:0005844'. synonym: "viral perturbation of polysomes" EXACT [] is_a: GO:0019057 ! modulation of host translation by virus [Term] id: GO:0046784 name: intronless viral mRNA export from host nucleus namespace: biological_process def: "The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation." [PMID:11598019] synonym: "intronless viral mRNA export from host cell nucleus" EXACT [] synonym: "intronless viral mRNA export out of nucleus" EXACT [] synonym: "intronless viral mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "intronless viral mRNA-nucleus export" EXACT [] is_a: GO:0006406 ! mRNA export from nucleus is_a: GO:0019048 ! virus-host interaction [Term] id: GO:0046785 name: microtubule polymerization namespace: biological_process def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051258 ! protein polymerization [Term] id: GO:0046786 name: viral replication complex formation and maintenance namespace: biological_process def: "The process of organizing and assembling viral replication proteins in preparation for viral replication." [ISBN:0781718325] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019079 ! viral genome replication [Term] id: GO:0046787 name: viral DNA repair namespace: biological_process def: "The process of restoring viral DNA after damage or errors in replication." [ISBN:0781718325] is_a: GO:0006281 ! DNA repair is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0019079 ! viral genome replication [Term] id: GO:0046788 name: egress of virus within host cell namespace: biological_process def: "The process of moving the (often) incomplete virion to the cell surface in order to be released from the cell. Egress can involve travel through the endoplasmic reticulum or cytoplasm and will often include final maturation stages of the virion, but it occurs entirely within the cell." [GOC:rh1, ISBN:0781718325] synonym: "movement of virus within host cell" EXACT [] synonym: "viral egress" EXACT [] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release [Term] id: GO:0046789 name: host cell surface receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor on the host cell surface." [GOC:ai, PMID:11511370] subset: gosubset_prok synonym: "cell surface antigen activity, host-interacting" RELATED [] synonym: "cell surface receptor ligand" RELATED [] is_a: GO:0005102 ! receptor binding is_a: GO:0046812 ! host cell surface binding [Term] id: GO:0046790 name: virion binding namespace: molecular_function def: "Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai] is_a: GO:0005488 ! binding [Term] id: GO:0046791 name: suppression by virus of host complement neutralization namespace: biological_process def: "Any viral process that results in the inhibition of complement neutralization of the host cell." [PMID:10587354] synonym: "negative regulation by virus of host complement neutralization" EXACT [] is_a: GO:0019053 ! suppression by virus of host extracellular antiviral response [Term] id: GO:0046792 name: suppression by virus of host cell cycle arrest namespace: biological_process def: "Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur." [PMID:9371605] synonym: "negative regulation by virus of cell cycle arrest" EXACT [] synonym: "viral inhibition of cell cycle arrest" EXACT [] is_a: GO:0019055 ! modification by virus of host cell cycle regulation [Term] id: GO:0046793 name: induction by virus of modification of host RNA polymerase II namespace: biological_process def: "The viral induction of modification to the host RNA polymerase II." [PMID:7637000] synonym: "virus-induced modification of host RNA polymerase II" EXACT [] is_a: GO:0019056 ! modulation by virus of host transcription [Term] id: GO:0046794 name: virion transport namespace: biological_process def: "The directed movement of a virion into, out of, or within a host cell." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport is_a: GO:0019048 ! virus-host interaction [Term] id: GO:0046795 name: intracellular virion transport namespace: biological_process def: "The directed movement of a virion within a host cell from one location to another." [GOC:ai, PMID:11733033] is_a: GO:0046794 ! virion transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0046796 name: viral genome transport in host cell namespace: biological_process def: "The directed movement of the viral genome(s) within a host cell." [GOC:ai, PMID:11090159] xref: Reactome:168271 "Transport of Ribonucleoproteins into the Host Nucleus" xref: Reactome:168274 "Export of Viral Ribonucleoproteins from Nucleus" xref: Reactome:168297 "Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein" xref: Reactome:168310 "Release of the RNP into the host cell nucleus" xref: Reactome:168317 "Recruitment of Karyopherin Beta to form a Trimeric Complex" xref: Reactome:168333 "NEP/NS2 Interacts with the Cellular Export Machinery" xref: Reactome:168337 "Docking and transport of the RNP:Karyopherin complex through the nuclear pore" xref: Reactome:168857 "Binding of vRNP:M1:NEP complex to CRM1 export receptor" xref: Reactome:168880 "vRNP Export through the nuclear pore" xref: Reactome:168893 "Binding of NEP/NS2 to vRNP:M1" is_a: GO:0006810 ! transport is_a: GO:0019048 ! virus-host interaction [Term] id: GO:0046797 name: viral procapsid maturation namespace: biological_process def: "The period of virion development during which the capsid components form the immature capsid and encapsulate the viral genome; the capsid often undergoes a number of structural alterations during this period." [PMID:10627558] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0021700 ! developmental maturation is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019069 ! viral capsid assembly [Term] id: GO:0046798 name: viral portal complex namespace: cellular_component def: "A multimeric ring of proteins through which the DNA enters and exits the viral capsid." [PMID:11602732] is_a: GO:0043234 ! protein complex is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0046799 name: recruitment of helicase-primase complex to DNA lesions namespace: biological_process def: "The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair." [ISBN:0781718325] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0046787 ! viral DNA repair [Term] id: GO:0046800 name: enhancement of virulence namespace: biological_process def: "OBSOLETE. Any process that activates or increases the severity of viral infection and subsequent disease." [PMID:10587354] comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism. is_obsolete: true [Term] id: GO:0046801 name: intracellular transport of viral capsid in host cell namespace: biological_process def: "The directed movement of viral capsid proteins within the host cell." [GOC:ai, PMID:9188566] synonym: "intracellular viral capsid transport" EXACT [] is_a: GO:0019060 ! intracellular transport of viral proteins in host cell relationship: part_of GO:0019069 ! viral capsid assembly [Term] id: GO:0046802 name: egress of viral procapsid from host cell nucleus namespace: biological_process def: "The exit of the immature viral procapsid from the nucleus of the host cell." [PMID:9601512, PMID:9765421] synonym: "nuclear egress of viral procapsid" EXACT [] is_a: GO:0006913 ! nucleocytoplasmic transport is_a: GO:0046801 ! intracellular transport of viral capsid in host cell [Term] id: GO:0046803 name: reduction of virulence namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the severity of viral infection and subsequent disease." [PMID:10982346] comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism. is_obsolete: true [Term] id: GO:0046804 name: peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine." [RESID:AA0330] subset: gosubset_prok synonym: "peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide" EXACT [] xref: RESID:AA0330 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0046805 name: protein-heme linkage via 1'-L-histidine namespace: biological_process def: "The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine)." [RESID:AA0329] subset: gosubset_prok synonym: "protein-haem linkage via 1'-L-histidine" EXACT [] xref: RESID:AA0329 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0046806 name: viral scaffold namespace: cellular_component def: "A complex of proteins that form a scaffold around which the viral capsid is constructed." [ISBN:0072370319] is_a: GO:0043234 ! protein complex is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0046807 name: viral scaffold assembly and maintenance namespace: biological_process def: "The assembly and maintenance of the viral scaffold around which the viral capsid is constructed." [ISBN:0072370319] comment: See also the cellular component term 'viral scaffold ; GO:0046806'. is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019069 ! viral capsid assembly [Term] id: GO:0046808 name: assemblon namespace: cellular_component def: "Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously." [PMID:8676489] is_a: GO:0044428 ! nuclear part [Term] id: GO:0046809 name: replication compartment namespace: cellular_component def: "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously." [PMID:9499108] is_a: GO:0044428 ! nuclear part [Term] id: GO:0046810 name: host cell extracellular matrix binding namespace: molecular_function def: "Interacting selectively and non-covalently with the extracellular matrix of a host cell." [PMID:7996163] subset: gosubset_prok is_a: GO:0050840 ! extracellular matrix binding [Term] id: GO:0046811 name: histone deacetylase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [GOC:ai, PMID:10482575] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0035033 ! histone deacetylase regulator activity [Term] id: GO:0046812 name: host cell surface binding namespace: molecular_function def: "Interacting selectively and non-covalently with the surface of a host cell." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0046813 name: virion attachment, binding of host cell surface receptor namespace: biological_process def: "The process during virion attachment where a virion binds to a host cell receptor, resulting in a conformational change of the virus protein." [ISBN:0879694971] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019062 ! virion attachment to host cell surface receptor [Term] id: GO:0046814 name: virion attachment, binding of host cell surface coreceptor namespace: biological_process def: "The process during virion attachment where a virion binds to a host cell surface receptor after an initial binding event has occurred, resulting in the fusion of the virion and host cell membranes and the initiation of viral entry." [ISBN:0879694971] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019062 ! virion attachment to host cell surface receptor [Term] id: GO:0046815 name: genome retention in viral capsid namespace: biological_process def: "Any process in which the viral genome is retained within the capsid during genome cleavage and packaging." [PMID:9696839] is_a: GO:0022415 ! viral reproductive process relationship: part_of GO:0019079 ! viral genome replication [Term] id: GO:0046816 name: virion transport vesicle namespace: cellular_component def: "A vesicle used to transport the partial or complete virion between cellular compartments." [PMID:7933124] is_a: GO:0031982 ! vesicle is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0046817 name: chemokine receptor antagonist activity namespace: molecular_function def: "Interacts with chemokine receptors to reduce the action of a chemokine." [GOC:ai, ISBN:0781718325] is_a: GO:0048019 ! receptor antagonist activity [Term] id: GO:0046818 name: dense nuclear body namespace: cellular_component def: "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously." [PMID:10233976] is_a: GO:0044428 ! nuclear part [Term] id: GO:0046819 name: protein secretion by the type V secretion system namespace: biological_process def: "The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway." [GOC:pamgo_curators] subset: gosubset_prok synonym: "autotransporter system" EXACT [] synonym: "protein secretion by the autotransporter system" EXACT [] synonym: "protein secretion by the type V protein secretion system" EXACT [] synonym: "type V protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0046820 name: 4-amino-4-deoxychorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate." [EC:2.6.1.85, RHEA:11675] comment: Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. subset: gosubset_prok synonym: "ADC synthase activity" EXACT [EC:2.6.1.85] synonym: "aminodeoxychorismate synthase activity" RELATED [] synonym: "chorismate:L-glutamine amido-ligase activity" EXACT [EC:2.6.1.85] synonym: "p-aminobenzoate synthetase" RELATED [] synonym: "PabB activity" RELATED [EC:2.6.1.85] synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] synonym: "para-aminobenzoic acid synthase activity" RELATED [] xref: EC:2.6.1.85 xref: KEGG:R01716 xref: MetaCyc:PABASYN-RXN xref: RHEA:11675 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0046821 name: extrachromosomal DNA namespace: cellular_component def: "DNA structures that are not part of a chromosome." [GOC:ai] subset: gosubset_prok xref: Wikipedia:Extrachromosomal_DNA is_a: GO:0044424 ! intracellular part [Term] id: GO:0046822 name: regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] is_a: GO:0032386 ! regulation of intracellular transport relationship: regulates GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0046823 name: negative regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf] synonym: "down regulation of nucleocytoplasmic transport" EXACT [] synonym: "down-regulation of nucleocytoplasmic transport" EXACT [] synonym: "downregulation of nucleocytoplasmic transport" EXACT [] synonym: "inhibition of nucleocytoplasmic transport" NARROW [] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport relationship: negatively_regulates GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0046824 name: positive regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] synonym: "activation of nucleocytoplasmic transport" NARROW [] synonym: "stimulation of nucleocytoplasmic transport" NARROW [] synonym: "up regulation of nucleocytoplasmic transport" EXACT [] synonym: "up-regulation of nucleocytoplasmic transport" EXACT [] synonym: "upregulation of nucleocytoplasmic transport" EXACT [] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport relationship: positively_regulates GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0046825 name: regulation of protein export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf] synonym: "regulation of protein export from cell nucleus" EXACT [] synonym: "regulation of protein export out of nucleus" EXACT [] synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "regulation of protein-nucleus export" EXACT [] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport relationship: regulates GO:0006611 ! protein export from nucleus [Term] id: GO:0046826 name: negative regulation of protein export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] synonym: "down regulation of protein export from nucleus" EXACT [] synonym: "down-regulation of protein export from nucleus" EXACT [] synonym: "downregulation of protein export from nucleus" EXACT [] synonym: "inhibition of protein export from nucleus" NARROW [] synonym: "negative regulation of protein export from cell nucleus" EXACT [] synonym: "negative regulation of protein export out of nucleus" EXACT [] synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "negative regulation of protein-nucleus export" EXACT [] is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0090317 ! negative regulation of intracellular protein transport relationship: negatively_regulates GO:0006611 ! protein export from nucleus [Term] id: GO:0046827 name: positive regulation of protein export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] synonym: "activation of protein export from nucleus" NARROW [] synonym: "positive regulation of protein export from cell nucleus" EXACT [] synonym: "positive regulation of protein export out of nucleus" EXACT [] synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "positive regulation of protein-nucleus export" EXACT [] synonym: "stimulation of protein export from nucleus" NARROW [] synonym: "up regulation of protein export from nucleus" EXACT [] synonym: "up-regulation of protein export from nucleus" EXACT [] synonym: "upregulation of protein export from nucleus" EXACT [] is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0090316 ! positive regulation of intracellular protein transport relationship: positively_regulates GO:0006611 ! protein export from nucleus [Term] id: GO:0046828 name: regulation of RNA import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf] synonym: "regulation of RNA import into cell nucleus" EXACT [] synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of RNA-nucleus import" EXACT [] is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport relationship: regulates GO:0006404 ! RNA import into nucleus [Term] id: GO:0046829 name: negative regulation of RNA import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf] synonym: "down regulation of RNA import into nucleus" EXACT [] synonym: "down-regulation of RNA import into nucleus" EXACT [] synonym: "downregulation of RNA import into nucleus" EXACT [] synonym: "inhibition of RNA import into nucleus" NARROW [] synonym: "negative regulation of RNA import into cell nucleus" EXACT [] synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of RNA-nucleus import" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046828 ! regulation of RNA import into nucleus relationship: negatively_regulates GO:0006404 ! RNA import into nucleus [Term] id: GO:0046830 name: positive regulation of RNA import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf] synonym: "activation of RNA import into nucleus" NARROW [] synonym: "positive regulation of RNA import into cell nucleus" EXACT [] synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of RNA-nucleus import" EXACT [] synonym: "stimulation of RNA import into nucleus" NARROW [] synonym: "up regulation of RNA import into nucleus" EXACT [] synonym: "up-regulation of RNA import into nucleus" EXACT [] synonym: "upregulation of RNA import into nucleus" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046828 ! regulation of RNA import into nucleus relationship: positively_regulates GO:0006404 ! RNA import into nucleus [Term] id: GO:0046831 name: regulation of RNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf] synonym: "regulation of RNA export from cell nucleus" EXACT [] synonym: "regulation of RNA export out of nucleus" EXACT [] synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "regulation of RNA-nucleus export" EXACT [] is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport relationship: regulates GO:0006405 ! RNA export from nucleus [Term] id: GO:0046832 name: negative regulation of RNA export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] synonym: "down regulation of RNA export from nucleus" EXACT [] synonym: "down-regulation of RNA export from nucleus" EXACT [] synonym: "downregulation of RNA export from nucleus" EXACT [] synonym: "inhibition of RNA export from nucleus" NARROW [] synonym: "negative regulation of RNA export from cell nucleus" EXACT [] synonym: "negative regulation of RNA export out of nucleus" EXACT [] synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "negative regulation of RNA-nucleus export" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046831 ! regulation of RNA export from nucleus relationship: negatively_regulates GO:0006405 ! RNA export from nucleus [Term] id: GO:0046833 name: positive regulation of RNA export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] synonym: "activation of RNA export from nucleus" NARROW [] synonym: "positive regulation of RNA export from cell nucleus" EXACT [] synonym: "positive regulation of RNA export out of nucleus" EXACT [] synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "positive regulation of RNA-nucleus export" EXACT [] synonym: "stimulation of RNA export from nucleus" NARROW [] synonym: "up regulation of RNA export from nucleus" EXACT [] synonym: "up-regulation of RNA export from nucleus" EXACT [] synonym: "upregulation of RNA export from nucleus" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046831 ! regulation of RNA export from nucleus relationship: positively_regulates GO:0006405 ! RNA export from nucleus [Term] id: GO:0046834 name: lipid phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0016310 ! phosphorylation is_a: GO:0030258 ! lipid modification [Term] id: GO:0046835 name: carbohydrate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0016310 ! phosphorylation is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0046836 name: glycolipid transport namespace: biological_process def: "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006869 ! lipid transport [Term] id: GO:0046838 name: phosphorylated carbohydrate dephosphorylation namespace: biological_process def: "The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0016311 ! dephosphorylation is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0046839 name: phospholipid dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0016311 ! dephosphorylation is_a: GO:0030258 ! lipid modification [Term] id: GO:0046841 name: trisporic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota." [GOC:ai] subset: gosubset_prok synonym: "trisporic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046842 name: trisporic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trisporic acid." [GOC:ai] subset: gosubset_prok synonym: "trisporic acid anabolism" EXACT [] synonym: "trisporic acid biosynthesis" EXACT [] synonym: "trisporic acid formation" EXACT [] synonym: "trisporic acid synthesis" EXACT [] is_a: GO:0046841 ! trisporic acid metabolic process [Term] id: GO:0046843 name: dorsal appendage formation namespace: biological_process def: "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007306 ! eggshell chorion assembly [Term] id: GO:0046844 name: micropyle formation namespace: biological_process def: "Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization." [ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007306 ! eggshell chorion assembly [Term] id: GO:0046845 name: branched duct epithelial cell fate determination, open tracheal system namespace: biological_process def: "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581] synonym: "branch cell fate determination" BROAD [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0046847 name: filopodium assembly namespace: biological_process def: "The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon." [GOC:dph, GOC:mah, GOC:tb] synonym: "filopodia biosynthesis" RELATED [] synonym: "filopodia formation" RELATED [] synonym: "filopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0030035 ! microspike assembly [Term] id: GO:0046848 name: hydroxyapatite binding namespace: molecular_function def: "Interacting selectively and non-covalently with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentine." [CHEBI:52255, GOC:curators] synonym: "hydroxylapatite binding" EXACT [GOC:vk] is_a: GO:0005488 ! binding [Term] id: GO:0046849 name: bone remodeling namespace: biological_process def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators] synonym: "bone remodelling" EXACT [] xref: Wikipedia:Bone_remodeling is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0046850 name: regulation of bone remodeling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai] is_a: GO:0034103 ! regulation of tissue remodeling relationship: regulates GO:0046849 ! bone remodeling [Term] id: GO:0046851 name: negative regulation of bone remodeling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." [GOC:ai] synonym: "down regulation of bone remodeling" EXACT [] synonym: "down-regulation of bone remodeling" EXACT [] synonym: "downregulation of bone remodeling" EXACT [] synonym: "inhibition of bone remodeling" NARROW [] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0046850 ! regulation of bone remodeling relationship: negatively_regulates GO:0046849 ! bone remodeling [Term] id: GO:0046852 name: positive regulation of bone remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai] synonym: "activation of bone remodeling" NARROW [] synonym: "stimulation of bone remodeling" NARROW [] synonym: "up regulation of bone remodeling" EXACT [] synonym: "up-regulation of bone remodeling" EXACT [] synonym: "upregulation of bone remodeling" EXACT [] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0046850 ! regulation of bone remodeling relationship: positively_regulates GO:0046849 ! bone remodeling [Term] id: GO:0046853 name: inositol or phosphatidylinositol phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into inositol or a phosphatidylinositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [CHEBI:24848, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "inositol and derivative phosphorylation" RELATED [GOC:curators] synonym: "myo-inositol and derivative phosphorylation" RELATED [] synonym: "myo-inositol or phosphatidyl-myo-inositol phosphorylation" NARROW [GOC:curators] is_a: GO:0006020 ! inositol metabolic process is_a: GO:0046835 ! carbohydrate phosphorylation [Term] id: GO:0046854 name: phosphatidylinositol phosphorylation namespace: biological_process alt_id: GO:0046837 def: "The process of introducing one or more phosphate groups into a phosphatidylinositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylinositol phosphate biosynthetic process" NARROW [] synonym: "phosphatidylinositol phosphate phosphorylation" NARROW [] synonym: "phosphoinositide phosphorylation" EXACT [] synonym: "PIP biosynthesis" NARROW [] synonym: "PtdInsP biosynthesis" NARROW [] xref: Reactome:110453 "Phosphorylation of PIP2 to PIP3 by Dp110" is_a: GO:0046488 ! phosphatidylinositol metabolic process is_a: GO:0046834 ! lipid phosphorylation [Term] id: GO:0046855 name: inositol phosphate dephosphorylation namespace: biological_process def: "The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "myo-inositol phosphate dephosphorylation" NARROW [] is_a: GO:0046838 ! phosphorylated carbohydrate dephosphorylation is_a: GO:0071545 ! inositol phosphate catabolic process [Term] id: GO:0046856 name: phosphatidylinositol dephosphorylation namespace: biological_process alt_id: GO:0046840 def: "The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylinositol phosphate catabolic process" NARROW [] synonym: "phosphatidylinositol phosphate dephosphorylation" NARROW [] synonym: "phosphoinositide dephosphorylation" EXACT [] synonym: "PIP catabolism" NARROW [] synonym: "PtdInsP catabolism" NARROW [] synonym: "PtdInsP dephosphorylation" NARROW [] xref: Reactome:110459 "PIP3 dephosphorylated to PIP2 by DPTEN" is_a: GO:0046488 ! phosphatidylinositol metabolic process is_a: GO:0046839 ! phospholipid dephosphorylation [Term] id: GO:0046857 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.7.1 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0046858 name: chlorosome namespace: cellular_component def: "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:14729689, PMID:15298919] subset: gosubset_prok xref: Wikipedia:Chlorosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0046859 name: hydrogenosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a hydrogenosome." [GOC:ai] synonym: "hydrogenosome membrane" EXACT [] is_a: GO:0031090 ! organelle membrane is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0042566 ! hydrogenosome [Term] id: GO:0046860 name: glycosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a glycosome." [GOC:ai] is_a: GO:0005778 ! peroxisomal membrane relationship: part_of GO:0020015 ! glycosome [Term] id: GO:0046861 name: glyoxysomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a glyoxysome." [GOC:ai] synonym: "glyoxysome membrane" EXACT [] is_a: GO:0005778 ! peroxisomal membrane [Term] id: GO:0046862 name: chromoplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope." [GOC:ai, GOC:mah] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0031898 ! chromoplast envelope [Term] id: GO:0046863 name: ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity namespace: molecular_function alt_id: GO:0018236 def: "Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate." [PMID:10430961, PMID:10965036, PMID:2404515] comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity" EXACT [GOC:dph, GOC:tb] synonym: "ribulose-bisphosphate carboxylase activase activity" EXACT [] synonym: "rubisco activase activity" EXACT [] synonym: "rubisco activator" EXACT [] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0046864 name: isoprenoid transport namespace: biological_process def: "The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:ai] subset: goslim_pir is_a: GO:0006869 ! lipid transport [Term] id: GO:0046865 name: terpenoid transport namespace: biological_process def: "The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai] is_a: GO:0046864 ! isoprenoid transport [Term] id: GO:0046866 name: tetraterpenoid transport namespace: biological_process def: "The directed movement of tetraterpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units." [GOC:ai] is_a: GO:0046865 ! terpenoid transport [Term] id: GO:0046867 name: carotenoid transport namespace: biological_process def: "The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai] is_a: GO:0046866 ! tetraterpenoid transport [Term] id: GO:0046868 name: mesosome namespace: cellular_component def: "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] subset: gosubset_prok xref: Wikipedia:Mesosome is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0046869 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide namespace: biological_process def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide." [RESID:AA0331] subset: gosubset_prok synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide" EXACT [] xref: RESID:AA0331 is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0046870 name: cadmium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with cadmium (Cd) ions." [GOC:ai] subset: gosubset_prok synonym: "cadmium binding" EXACT [] synonym: "copper/cadmium binding" BROAD [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0046871 name: N-acetylgalactosamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine." [CHEBI:28800, GOC:ai] synonym: "N-acetylgalactosamine lectin" RELATED [] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0046872 name: metal ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with any metal ion." [GOC:ai] subset: gosubset_prok synonym: "heavy metal binding" NARROW [] synonym: "metal binding" EXACT [] is_a: GO:0043169 ! cation binding [Term] id: GO:0046873 name: metal ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "heavy metal ion porter activity" NARROW [] synonym: "heavy metal ion transporter activity" NARROW [] synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "heavy metal-exporting ATPase activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity [Term] id: GO:0046874 name: quinolinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] subset: gosubset_prok synonym: "quinolinate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0046875 name: ephrin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an ephrin receptor." [GOC:ai] synonym: "Eph receptor binding" EXACT [] synonym: "ephrin" NARROW [] synonym: "GPI-linked ephrin" NARROW [] synonym: "transmembrane ephrin" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0046876 name: 3,4-didehydroretinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "blue-sensitive opsin" NARROW [] synonym: "green-sensitive opsin" NARROW [] synonym: "long-wave-sensitive opsin" NARROW [] synonym: "opsin" NARROW [] synonym: "red-sensitive opsin" NARROW [] synonym: "short-wave-sensitive opsin" NARROW [] synonym: "UV-sensitive opsin" NARROW [] synonym: "violet-sensitive opsin" NARROW [] is_a: GO:0005501 ! retinoid binding [Term] id: GO:0046877 name: regulation of saliva secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or group of cells." [GOC:ai] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051046 ! regulation of secretion relationship: regulates GO:0046541 ! saliva secretion [Term] id: GO:0046878 name: positive regulation of saliva secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." [GOC:ai] synonym: "activation of saliva secretion" NARROW [] synonym: "stimulation of saliva secretion" NARROW [] synonym: "up regulation of saliva secretion" EXACT [] synonym: "up-regulation of saliva secretion" EXACT [] synonym: "upregulation of saliva secretion" EXACT [] is_a: GO:0046877 ! regulation of saliva secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060456 ! positive regulation of digestive system process relationship: positively_regulates GO:0046541 ! saliva secretion [Term] id: GO:0046879 name: hormone secretion namespace: biological_process def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0009914 ! hormone transport is_a: GO:0023061 ! signal release is_a: GO:0032940 ! secretion by cell [Term] id: GO:0046880 name: regulation of follicle-stimulating hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] synonym: "regulation of follicle stimulating hormone secretion" EXACT [] synonym: "regulation of FSH secretion" EXACT [] is_a: GO:0032276 ! regulation of gonadotropin secretion relationship: regulates GO:0046884 ! follicle-stimulating hormone secretion [Term] id: GO:0046881 name: positive regulation of follicle-stimulating hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] synonym: "activation of follicle-stimulating hormone secretion" NARROW [] synonym: "positive regulation of follicle stimulating hormone secretion" EXACT [] synonym: "stimulation of follicle-stimulating hormone secretion" NARROW [] synonym: "up regulation of follicle-stimulating hormone secretion" EXACT [] synonym: "up-regulation of follicle-stimulating hormone secretion" EXACT [] synonym: "upregulation of follicle-stimulating hormone secretion" EXACT [] is_a: GO:0032278 ! positive regulation of gonadotropin secretion is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion relationship: positively_regulates GO:0046884 ! follicle-stimulating hormone secretion [Term] id: GO:0046882 name: negative regulation of follicle-stimulating hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] synonym: "down regulation of follicle-stimulating hormone secretion" EXACT [] synonym: "down-regulation of follicle-stimulating hormone secretion" EXACT [] synonym: "downregulation of follicle-stimulating hormone secretion" EXACT [] synonym: "inhibition of follicle-stimulating hormone secretion" NARROW [] synonym: "negative regulation of follicle stimulating hormone secretion" EXACT [] is_a: GO:0032277 ! negative regulation of gonadotropin secretion is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion relationship: negatively_regulates GO:0046884 ! follicle-stimulating hormone secretion [Term] id: GO:0046883 name: regulation of hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells." [GOC:ai] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0051046 ! regulation of secretion is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0046879 ! hormone secretion [Term] id: GO:0046884 name: follicle-stimulating hormone secretion namespace: biological_process def: "The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "follicle stimulating hormone secretion" EXACT [] synonym: "follitropin secretion" EXACT [] synonym: "FSH secretion" EXACT [] is_a: GO:0032274 ! gonadotropin secretion [Term] id: GO:0046885 name: regulation of hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "regulation of hormone anabolism" EXACT [] synonym: "regulation of hormone biosynthesis" EXACT [] synonym: "regulation of hormone formation" EXACT [] synonym: "regulation of hormone synthesis" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: regulates GO:0042446 ! hormone biosynthetic process [Term] id: GO:0046886 name: positive regulation of hormone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "activation of hormone biosynthetic process" NARROW [] synonym: "positive regulation of hormone anabolism" EXACT [] synonym: "positive regulation of hormone biosynthesis" EXACT [] synonym: "positive regulation of hormone formation" EXACT [] synonym: "positive regulation of hormone synthesis" EXACT [] synonym: "stimulation of hormone biosynthetic process" NARROW [] synonym: "up regulation of hormone biosynthetic process" EXACT [] synonym: "up-regulation of hormone biosynthetic process" EXACT [] synonym: "upregulation of hormone biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process relationship: positively_regulates GO:0042446 ! hormone biosynthetic process [Term] id: GO:0046887 name: positive regulation of hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells." [GOC:ai] synonym: "activation of hormone secretion" NARROW [] synonym: "stimulation of hormone secretion" NARROW [] synonym: "up regulation of hormone secretion" EXACT [] synonym: "up-regulation of hormone secretion" EXACT [] synonym: "upregulation of hormone secretion" EXACT [] is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion relationship: positively_regulates GO:0046879 ! hormone secretion [Term] id: GO:0046888 name: negative regulation of hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells." [GOC:ai] synonym: "down regulation of hormone secretion" EXACT [] synonym: "down-regulation of hormone secretion" EXACT [] synonym: "downregulation of hormone secretion" EXACT [] synonym: "inhibition of hormone secretion" NARROW [] is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion relationship: negatively_regulates GO:0046879 ! hormone secretion [Term] id: GO:0046889 name: positive regulation of lipid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] subset: gosubset_prok synonym: "activation of lipid biosynthetic process" NARROW [] synonym: "positive regulation of lipid anabolism" EXACT [] synonym: "positive regulation of lipid biosynthesis" EXACT [] synonym: "positive regulation of lipid formation" EXACT [] synonym: "positive regulation of lipid synthesis" EXACT [] synonym: "positive regulation of lipogenesis" EXACT [GOC:sl] synonym: "stimulation of lipid biosynthetic process" NARROW [] synonym: "up regulation of lipid biosynthetic process" EXACT [] synonym: "up-regulation of lipid biosynthetic process" EXACT [] synonym: "upregulation of lipid biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: positively_regulates GO:0008610 ! lipid biosynthetic process [Term] id: GO:0046890 name: regulation of lipid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] subset: gosubset_prok synonym: "regulation of lipid anabolism" EXACT [] synonym: "regulation of lipid biosynthesis" EXACT [] synonym: "regulation of lipid formation" EXACT [] synonym: "regulation of lipid synthesis" EXACT [] synonym: "regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0019216 ! regulation of lipid metabolic process relationship: regulates GO:0008610 ! lipid biosynthetic process [Term] id: GO:0046891 name: peptidyl-cysteine S-carbamoylation namespace: biological_process def: "The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine." [RESID:AA0332] subset: gosubset_prok xref: RESID:AA0332 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0046892 name: peptidyl-S-carbamoyl-L-cysteine dehydration namespace: biological_process def: "The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine." [PMID:12586941, RESID:AA0333] subset: gosubset_prok synonym: "formation of peptidyl-S-cyanocysteine" EXACT [] synonym: "formation of peptidyl-serine thiocyanate ester" EXACT [] xref: RESID:AA0333 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018249 ! protein dehydration [Term] id: GO:0046893 name: iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation namespace: biological_process def: "The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase." [RESID:AA0334] subset: gosubset_prok xref: RESID:AA0334 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0046894 name: enzyme active site formation via S-amidino-L-cysteine namespace: biological_process def: "The transient amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335] subset: gosubset_prok xref: RESID:AA0335 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0046895 name: N-terminal peptidyl-isoleucine methylation namespace: biological_process def: "The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine." [RESID:AA0336] subset: gosubset_prok xref: RESID:AA0336 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018203 ! peptidyl-isoleucine modification [Term] id: GO:0046896 name: N-terminal peptidyl-leucine methylation namespace: biological_process def: "The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine." [RESID:AA0337] subset: gosubset_prok xref: RESID:AA0337 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018204 ! peptidyl-leucine modification [Term] id: GO:0046897 name: N-terminal peptidyl-tyrosine methylation namespace: biological_process def: "The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine." [RESID:AA0338] subset: gosubset_prok xref: RESID:AA0338 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0046898 name: response to cycloheximide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [CHEBI:27641, GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response to actidione" EXACT [] is_a: GO:0014071 ! response to cycloalkane [Term] id: GO:0046899 name: nucleoside triphosphate adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10] synonym: "GTP:AMP phosphotransferase" NARROW [] synonym: "guanosine triphosphate-adenylate kinase" NARROW [] synonym: "isozyme 3 of adenylate kinase activity" EXACT [EC:2.7.4.10] synonym: "nucleoside triphosphate-adenosine monophosphate transphosphorylase activity" EXACT [] synonym: "nucleoside-triphosphate-adenylate kinase activity" EXACT [] synonym: "nucleoside-triphosphate:AMP phosphotransferase activity" EXACT [EC:2.7.4.10] xref: EC:2.7.4.10 xref: MetaCyc:2.7.4.10-RXN xref: Reactome:78160 "nucleoside triphosphate adenylate kinase activity" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: GO:0046900 name: tetrahydrofolylpolyglutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai] subset: gosubset_prok synonym: "tetrahydrofolyl-[Glu](n) metabolic process" EXACT [] synonym: "tetrahydrofolyl-[Glu](n) metabolism" EXACT [] synonym: "tetrahydrofolylpolyglutamate metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006760 ! folic acid-containing compound metabolic process [Term] id: GO:0046901 name: tetrahydrofolylpolyglutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai] subset: gosubset_prok synonym: "folic-acid containing compound polyglutamylation" BROAD [GOC:dhl] synonym: "tetrahydrofolate polyglutamylation" EXACT [GOC:bf, KEGG:ec00790] synonym: "tetrahydrofolyl-[Glu](n) biosynthesis" EXACT [] synonym: "tetrahydrofolyl-[Glu](n) biosynthetic process" EXACT [] synonym: "tetrahydrofolylpolyglutamate anabolism" EXACT [] synonym: "tetrahydrofolylpolyglutamate biosynthesis" EXACT [] synonym: "tetrahydrofolylpolyglutamate formation" EXACT [] synonym: "tetrahydrofolylpolyglutamate synthesis" EXACT [] synonym: "THF polyglutamylation" EXACT [GOC:bf, KEGG:ec00790] is_a: GO:0009396 ! folic acid-containing compound biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046900 ! tetrahydrofolylpolyglutamate metabolic process [Term] id: GO:0046902 name: regulation of mitochondrial membrane permeability namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf] synonym: "regulation of transport across mitochondrial membrane" EXACT [] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0006839 ! mitochondrial transport [Term] id: GO:0046903 name: secretion namespace: biological_process def: "The controlled release of a substance by a cell, a group of cells, or a tissue." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0046904 name: calcium oxalate binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0046905 name: phytoene synthase activity namespace: molecular_function def: "Catalysis of the reaction: prephytoene pyrophosphate = phytoene + diphosphate." [GOC:ai, PMID:12641468] comment: Note that this should not be confused with 'geranylgeranyl-diphosphate geranylgeranyltransferase activity ; GO:0016767', EC:2.5.1.32. This activity is the second part of the formation of phytoene from geranylgeranyl-diphosphate, the first stage of which is catalyzed by EC:2.5.1.32. is_a: GO:0003824 ! catalytic activity [Term] id: GO:0046906 name: tetrapyrrole binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [CHEBI:26932, GOC:curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "porphyrin binding" NARROW [] is_a: GO:0005488 ! binding [Term] id: GO:0046907 name: intracellular transport namespace: biological_process def: "The directed movement of substances within a cell." [GOC:ai] subset: gosubset_prok is_a: GO:0006810 ! transport is_a: GO:0051649 ! establishment of localization in cell [Term] id: GO:0046908 name: negative regulation of crystal formation namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the spontaneous (nonenzymatic) formation of crystals in a solution, for example, calcium oxalate crystals in urine." [GOC:ai] comment: This term was made obsolete because a more appropriate term was created. synonym: "negative regulation of mineralization" RELATED [] is_obsolete: true replaced_by: GO:0050801 [Term] id: GO:0046909 name: intermembrane transport namespace: biological_process def: "The directed movement of substances between the intracellular membranes of a cell, for example, the transfer of glycolipids from the endoplasmic reticulum to other cellular membrane structures in which they reside." [GOC:ai, PMID:10671554] is_a: GO:0046907 ! intracellular transport [Term] id: GO:0046910 name: pectinesterase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any pectinesterase enzyme." [GOC:ai, PMID:10880981] comment: See also the molecular function term 'pectinesterase activity ; GO:0030599'. is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0046911 name: metal chelating activity namespace: molecular_function def: "The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] subset: gosubset_prok synonym: "heavy metal chelation" NARROW [] synonym: "metal chelation" EXACT [] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0046912 name: transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl] subset: gosubset_prok xref: EC:2.3.3 is_a: GO:0016746 ! transferase activity, transferring acyl groups [Term] id: GO:0046914 name: transition metal ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0046872 ! metal ion binding [Term] id: GO:0046915 name: transition metal ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0046916 name: cellular transition metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055076 ! transition metal ion homeostasis [Term] id: GO:0046917 name: triphosphoribosyl-dephospho-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine." [EC:2.7.8.25] subset: gosubset_prok synonym: "2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity" EXACT [EC:2.7.8.25] synonym: "ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity" EXACT [EC:2.7.8.25] synonym: "ATP:dephospho-CoA 5-triphosphoribosyl transferase activity" EXACT [] synonym: "CitG activity" RELATED [EC:2.7.8.25] xref: EC:2.7.8.25 xref: MetaCyc:2.7.8.25-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0046918 name: N-terminal peptidyl-glycine N-palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine." [RESID:AA0339] comment: Palmitoylation of glycine only occurs when glycine is at the N-terminal position of a protein. subset: gosubset_prok xref: RESID:AA0339 is_a: GO:0006500 ! N-terminal protein palmitoylation [Term] id: GO:0046919 name: pyruvyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another." [GOC:ai] is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0046920 name: alpha(1,3)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,3)-linkage." [GOC:ai] xref: EC:2.4.1.- is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0046921 name: alpha(1,6)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,6)-linkage." [GOC:ai] xref: EC:2.4.1.- is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0046922 name: peptide-O-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221] synonym: "GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.221] synonym: "GDP-fucose protein O-fucosyltransferase activity" EXACT [EC:2.4.1.221] synonym: "GDP-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221] synonym: "GDP-L-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221] xref: EC:2.4.1.221 xref: MetaCyc:2.4.1.221-RXN is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0046923 name: ER retention sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai] synonym: "endoplasmic reticulum retention sequence binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0046924 name: peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine namespace: biological_process def: "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine." [PMID:12696888, RESID:AA0340] subset: gosubset_prok xref: RESID:AA0340 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0046925 name: peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine namespace: biological_process def: "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine." [PMID:12696888, RESID:AA0341] subset: gosubset_prok xref: RESID:AA0341 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0046926 name: peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine namespace: biological_process def: "The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888, RESID:AA0342] subset: gosubset_prok xref: RESID:AA0342 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0046927 name: peptidyl-threonine racemization namespace: biological_process def: "The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888] subset: gosubset_prok is_a: GO:0018085 ! peptidyl-L-amino acid racemization is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0046928 name: regulation of neurotransmitter secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell or group of cells." [GOC:ai] is_a: GO:0050804 ! regulation of synaptic transmission is_a: GO:0051046 ! regulation of secretion is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0046929 name: negative regulation of neurotransmitter secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai] synonym: "conotoxin activity" NARROW [] synonym: "down regulation of neurotransmitter secretion" EXACT [] synonym: "down-regulation of neurotransmitter secretion" EXACT [] synonym: "downregulation of neurotransmitter secretion" EXACT [] synonym: "inhibition of neurotransmitter secretion" NARROW [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051589 ! negative regulation of neurotransmitter transport relationship: negatively_regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0046930 name: pore complex namespace: cellular_component def: "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "channel-forming toxin activity" RELATED [] synonym: "pore" EXACT [] synonym: "pore-forming toxin activity" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0016021 ! integral to membrane [Term] id: GO:0046931 name: pore complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases." [GOC:jl, GOC:mah] comment: See also the cellular component term 'pore complex ; GO:0046930'. subset: gosubset_prok synonym: "channel-forming toxin activity" RELATED [] synonym: "pore biosynthesis" EXACT [] synonym: "pore complex biogenesis" RELATED [GOC:mah] synonym: "pore formation" EXACT [] synonym: "pore-forming toxin activity" RELATED [] is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0046932 name: sodium-transporting ATP synthase activity, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) = ATP + H2O + Na+(in), by a rotational mechanism." [EC:3.6.3.15, TC:3.A.2.1.2] synonym: "sodium-translocating F-type ATPase activity" EXACT [] synonym: "sodium-transporting two-sector ATPase activity" EXACT [] xref: MetaCyc:3.6.3.15-RXN is_a: GO:0015081 ! sodium ion transmembrane transporter activity [Term] id: GO:0046933 name: hydrogen ion transporting ATP synthase activity, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1] subset: gosubset_prok synonym: "H+-transporting ATP synthase activity" EXACT [EC:3.6.3.14] synonym: "hydrogen ion translocating F-type ATPase activity" EXACT [] synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT [] xref: MetaCyc:ATPSYN-RXN xref: Reactome:78757 "hydrogen ion transporting ATP synthase activity, rotational mechanism" is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity [Term] id: GO:0046934 name: phosphatidylinositol-4,5-bisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+)." [EC:2.7.1.153, RHEA:21295] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.153] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "type I phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.153] xref: EC:2.7.1.153 xref: KEGG:R04545 xref: MetaCyc:2.7.1.153-RXN xref: Reactome:78763 "phosphatidylinositol-4,5-bisphosphate 3-kinase activity" xref: RHEA:21295 is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity [Term] id: GO:0046935 name: 1-phosphatidylinositol-3-kinase regulator activity namespace: molecular_function def: "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai] comment: See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'. synonym: "1-phosphatidylinositol 3-kinase regulator activity" EXACT [] synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" NARROW [] is_a: GO:0035014 ! phosphatidylinositol 3-kinase regulator activity [Term] id: GO:0046936 name: deoxyadenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: deoxyadenosine + H2O = deoxyinosine + NH3." [EC:3.5.4.4, GOC:ai] synonym: "deoxyadenosine deaminase reaction" EXACT [] xref: MetaCyc:ADDALT-RXN is_a: GO:0019239 ! deaminase activity [Term] id: GO:0046937 name: phytochelatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phytochelatin metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0046938 name: phytochelatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phytochelatin anabolism" EXACT [] synonym: "phytochelatin biosynthesis" EXACT [] synonym: "phytochelatin formation" EXACT [] synonym: "phytochelatin synthesis" EXACT [] is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0046937 ! phytochelatin metabolic process [Term] id: GO:0046939 name: nucleotide phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai] subset: gosubset_prok is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0016310 ! phosphorylation [Term] id: GO:0046940 name: nucleoside monophosphate phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside." [GOC:ai] subset: gosubset_prok is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0046939 ! nucleotide phosphorylation [Term] id: GO:0046941 name: azetidine-2-carboxylic acid acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid." [PMID:12761200] xref: EC:2.3.1.- is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0046942 name: carboxylic acid transport namespace: biological_process def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] subset: gosubset_prok is_a: GO:0015849 ! organic acid transport [Term] id: GO:0046943 name: carboxylic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] subset: gosubset_prok xref: Reactome:78420 "carboxylic acid transmembrane transporter activity" is_a: GO:0005342 ! organic acid transmembrane transporter activity [Term] id: GO:0046944 name: protein carbamoylation namespace: biological_process def: "The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid carbamoylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0046945 name: N-terminal peptidyl-alanine N-carbamoylation namespace: biological_process def: "The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine." [RESID:AA0343] subset: gosubset_prok synonym: "N-terminal peptidyl-alanine N-carbamylation" RELATED [] xref: RESID:AA0343 is_a: GO:0018194 ! peptidyl-alanine modification is_a: GO:0046944 ! protein carbamoylation is_a: GO:0050990 ! N-terminal protein amino acid carbamoylation [Term] id: GO:0046946 name: hydroxylysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PubChem_Compound:1029] subset: gosubset_prok synonym: "hydroxylysine metabolism" EXACT [] is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0046947 name: hydroxylysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hydroxylysine anabolism" EXACT [] synonym: "hydroxylysine biosynthesis" EXACT [] synonym: "hydroxylysine formation" EXACT [] synonym: "hydroxylysine synthesis" EXACT [] is_a: GO:0009067 ! aspartate family amino acid biosynthetic process is_a: GO:0046946 ! hydroxylysine metabolic process [Term] id: GO:0046948 name: hydroxylysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hydroxylysine breakdown" EXACT [] synonym: "hydroxylysine catabolism" EXACT [] synonym: "hydroxylysine degradation" EXACT [] is_a: GO:0009068 ! aspartate family amino acid catabolic process is_a: GO:0046946 ! hydroxylysine metabolic process [Term] id: GO:0046949 name: fatty-acyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fatty acyl CoA biosynthetic process" EXACT [GOC:curators] synonym: "fatty-acyl-CoA anabolism" EXACT [] synonym: "fatty-acyl-CoA biosynthesis" EXACT [] synonym: "fatty-acyl-CoA formation" EXACT [] synonym: "fatty-acyl-CoA synthesis" EXACT [] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process is_a: GO:0071616 ! acyl-CoA biosynthetic process [Term] id: GO:0046950 name: cellular ketone body metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "ketone body metabolism" EXACT [] xref: Reactome:1253004 "Ketone body metabolism" xref: Reactome:1279934 "Ketone body metabolism" xref: Reactome:1298830 "Ketone body metabolism" xref: Reactome:1326508 "Ketone body metabolism" xref: Reactome:1352615 "Ketone body metabolism" xref: Reactome:1372846 "Ketone body metabolism" xref: Reactome:1392859 "Ketone body metabolism" xref: Reactome:1417334 "Ketone body metabolism" xref: Reactome:1450423 "Ketone body metabolism" xref: Reactome:1470952 "Ketone body metabolism" xref: Reactome:1482993 "Ketone body metabolism" xref: Reactome:1496762 "Ketone body metabolism" xref: Reactome:1514152 "Ketone body metabolism" xref: Reactome:1520980 "Ketone body metabolism" xref: Reactome:1526731 "Ketone body metabolism" xref: Reactome:1532454 "Ketone body metabolism" xref: Reactome:1536000 "Ketone body metabolism" xref: Reactome:1538002 "Ketone body metabolism" xref: Reactome:1539255 "Ketone body metabolism" xref: Reactome:1540307 "Ketone body metabolism" xref: Reactome:74182 "Ketone body metabolism" is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0046951 name: ketone body biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ketone body anabolism" EXACT [] synonym: "ketone body biosynthesis" EXACT [] synonym: "ketone body formation" EXACT [] synonym: "ketone body synthesis" EXACT [] xref: Reactome:1253003 "Synthesis of Ketone Bodies" xref: Reactome:1279933 "Synthesis of Ketone Bodies" xref: Reactome:1298829 "Synthesis of Ketone Bodies" xref: Reactome:1326507 "Synthesis of Ketone Bodies" xref: Reactome:1352614 "Synthesis of Ketone Bodies" xref: Reactome:1372845 "Synthesis of Ketone Bodies" xref: Reactome:1392858 "Synthesis of Ketone Bodies" xref: Reactome:1417333 "Synthesis of Ketone Bodies" xref: Reactome:1450422 "Synthesis of Ketone Bodies" xref: Reactome:1470951 "Synthesis of Ketone Bodies" xref: Reactome:1482992 "Synthesis of Ketone Bodies" xref: Reactome:1496761 "Synthesis of Ketone Bodies" xref: Reactome:1514151 "Synthesis of Ketone Bodies" xref: Reactome:1520979 "Synthesis of Ketone Bodies" xref: Reactome:1526730 "Synthesis of Ketone Bodies" xref: Reactome:1532453 "Synthesis of Ketone Bodies" xref: Reactome:1535999 "Synthesis of Ketone Bodies" xref: Reactome:1538001 "Synthesis of Ketone Bodies" xref: Reactome:1539254 "Synthesis of Ketone Bodies" xref: Reactome:1540306 "Synthesis of Ketone Bodies" xref: Reactome:77111 "Synthesis of Ketone Bodies" is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0046950 ! cellular ketone body metabolic process [Term] id: GO:0046952 name: ketone body catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ketone body breakdown" EXACT [] synonym: "ketone body catabolism" EXACT [] synonym: "ketone body degradation" EXACT [] xref: Reactome:1253006 "Utilization of Ketone Bodies" xref: Reactome:1279936 "Utilization of Ketone Bodies" xref: Reactome:1298832 "Utilization of Ketone Bodies" xref: Reactome:1326510 "Utilization of Ketone Bodies" xref: Reactome:1352617 "Utilization of Ketone Bodies" xref: Reactome:1372848 "Utilization of Ketone Bodies" xref: Reactome:1392861 "Utilization of Ketone Bodies" xref: Reactome:1417336 "Utilization of Ketone Bodies" xref: Reactome:1450425 "Utilization of Ketone Bodies" xref: Reactome:1470956 "Utilization of Ketone Bodies" xref: Reactome:1482997 "Utilization of Ketone Bodies" xref: Reactome:1496766 "Utilization of Ketone Bodies" xref: Reactome:1514156 "Utilization of Ketone Bodies" xref: Reactome:1520982 "Utilization of Ketone Bodies" xref: Reactome:1526735 "Utilization of Ketone Bodies" xref: Reactome:1532458 "Utilization of Ketone Bodies" xref: Reactome:1536003 "Utilization of Ketone Bodies" xref: Reactome:1538003 "Utilization of Ketone Bodies" xref: Reactome:1539257 "Utilization of Ketone Bodies" xref: Reactome:77108 "Utilization of Ketone Bodies" is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046950 ! cellular ketone body metabolic process [Term] id: GO:0046956 name: positive phototaxis namespace: biological_process alt_id: GO:0046954 def: "The directed movement of a cell or organism towards a source of light." [GOC:ai] synonym: "positive phototactic behavior" EXACT [] synonym: "positive phototactic behaviour" EXACT [] synonym: "positive taxis in response to light" EXACT [] is_a: GO:0042331 ! phototaxis is_a: GO:0052128 ! positive energy taxis [Term] id: GO:0046957 name: negative phototaxis namespace: biological_process alt_id: GO:0046955 def: "The directed movement of a cell or organism away from a source of light." [GOC:ai] synonym: "negative phototactic behavior" EXACT [] synonym: "negative phototactic behaviour" EXACT [] synonym: "negative taxis in response to light" EXACT [] is_a: GO:0042331 ! phototaxis is_a: GO:0052129 ! negative energy taxis [Term] id: GO:0046958 name: nonassociative learning namespace: biological_process def: "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment." [ISBN:0582227089] synonym: "unconditional response" EXACT [] is_a: GO:0007612 ! learning [Term] id: GO:0046959 name: habituation namespace: biological_process def: "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089] xref: Wikipedia:Habituation is_a: GO:0046958 ! nonassociative learning [Term] id: GO:0046960 name: sensitization namespace: biological_process def: "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089] xref: Wikipedia:Sensitization is_a: GO:0046958 ! nonassociative learning [Term] id: GO:0046961 name: proton-transporting ATPase activity, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14] subset: gosubset_prok synonym: "ATP phosphohydrolase (H+-transporting) activity" EXACT [EC:3.6.3.14] synonym: "ATP synthase activity" BROAD [EC:3.6.3.14] synonym: "bacterial Ca2+/Mg2+ ATPase" NARROW [EC:3.6.3.14] synonym: "chloroplast ATPase activity" NARROW [EC:3.6.3.14] synonym: "coupling factors (Fo, F1 and CF1)" RELATED [EC:3.6.3.14] synonym: "F(0)F(1)-ATPase activity" NARROW [EC:3.6.3.14] synonym: "F(1)-ATPase activity" NARROW [EC:3.6.3.14] synonym: "F(o)F(1)-ATPase activity" NARROW [EC:3.6.3.14] synonym: "F0F1-ATPase" NARROW [EC:3.6.3.14] synonym: "F1-ATPase" NARROW [EC:3.6.3.14] synonym: "FoF1-ATPase" NARROW [EC:3.6.3.14] synonym: "H(+)-transporting ATP synthase activity" EXACT [EC:3.6.3.14] synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.14] synonym: "H+-transporting ATPase activity" EXACT [EC:3.6.3.14] synonym: "H+-transporting two-sector ATPase" NARROW [EC:3.6.3.14] synonym: "hydrogen ion translocating A-type ATPase activity" NARROW [] synonym: "hydrogen ion translocating F-type ATPase activity" NARROW [] synonym: "hydrogen ion translocating V-type ATPase activity" NARROW [] synonym: "hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [] synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW [] synonym: "mitochondrial ATPase activity" NARROW [EC:3.6.3.14] xref: MetaCyc:ATPSYN-RXN is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0046962 name: sodium-transporting ATPase activity, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out), by a rotational mechanism." [EC:3.6.3.15] synonym: "ATP phosphohydrolase (Na+-transporting) activity" EXACT [EC:3.6.3.15] synonym: "ATP synthase, sodium ion specific activity" EXACT [EC:3.6.3.145] synonym: "Na(+)-translocating ATPase activity" BROAD [EC:3.6.3.15] synonym: "Na(+)-transporting two-sector ATPase activity" EXACT [EC:3.6.3.15] synonym: "Na+-translocating ATPase activity" EXACT [EC:3.6.3.15] synonym: "Na+-translocating F1Fo-ATPase" NARROW [EC:3.6.3.15] synonym: "Na+-transporting two-sector ATPase" NARROW [EC:3.6.3.15] synonym: "sodium transporting ATPase activity, rotational mechanism" EXACT [] synonym: "sodium-translocating F-type ATPase activity" NARROW [] synonym: "sodium-translocating V-type ATPase activity" NARROW [] synonym: "sodium-transporting two-sector ATPase activity" NARROW [] synonym: "vacuolar-type Na+-ATPase" NARROW [EC:3.6.3.15] synonym: "vacuolar-type Na+-translocating ATPase" NARROW [EC:3.6.3.15] xref: MetaCyc:3.6.3.15-RXN is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0046963 name: 3'-phosphoadenosine 5'-phosphosulfate transport namespace: biological_process def: "The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "3'-phosphoadenosine 5'-phosphosulphate transport" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate transport" EXACT [] synonym: "PAPS transport" EXACT [] is_a: GO:0015860 ! purine nucleoside transport [Term] id: GO:0046964 name: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "3'-phosphoadenosine 5'-phosphosulphate transporter activity" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity" EXACT [] synonym: "PAPS transporter activity" EXACT [] xref: Reactome:78839 "3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity" is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity [Term] id: GO:0046965 name: retinoid X receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a retinoid X receptor." [GOC:ai] synonym: "RXR binding" EXACT [] is_a: GO:0042974 ! retinoic acid receptor binding [Term] id: GO:0046966 name: thyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a thyroid hormone receptor." [GOC:ai] synonym: "ligand-dependent thyroid hormone receptor interactor activity" NARROW [] is_a: GO:0008134 ! transcription factor binding is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0046967 name: cytosol to ER transport namespace: biological_process def: "The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell." [GOC:ai] synonym: "cytosol to endoplasmic reticulum transport" EXACT [] is_a: GO:0046907 ! intracellular transport [Term] id: GO:0046968 name: peptide antigen transport namespace: biological_process def: "The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0015833 ! peptide transport relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0046969 name: NAD-dependent histone deacetylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, EC:3.5.1.98, RHEA:24551] xref: EC:3.5.1.98 is_a: GO:0017136 ! NAD-dependent histone deacetylase activity is_a: GO:0032129 ! histone deacetylase activity (H3-K9 specific) [Term] id: GO:0046970 name: NAD-dependent histone deacetylase activity (H4-K16 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [EC:3.5.1.17, EC:3.5.1.98, RHEA:24551] xref: EC:3.5.1.98 is_a: GO:0017136 ! NAD-dependent histone deacetylase activity [Term] id: GO:0046972 name: histone acetyltransferase activity (H4-K16 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4." [EC:2.3.1.48] synonym: "histone lysine acetyltransferase activity (H4-K16 specific)" EXACT [] is_a: GO:0010485 ! H4 histone acetyltransferase activity [Term] id: GO:0046973 name: histone lysine N-methyltransferase activity (H3-K24 specific) namespace: molecular_function def: "OBSOLETE. Catalysis of the addition of a methyl group onto lysine at position 24 of the histone H3 protein." [GOC:ai] comment: This term was made obsolete because there is no lysine at position 24 of histone H3. is_obsolete: true consider: GO:0042800 [Term] id: GO:0046974 name: histone methyltransferase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai] synonym: "histone lysine N-methyltransferase activity (H3-K9 specific)" EXACT [] synonym: "histone methylase activity (H3-K9 specific)" EXACT [GOC:mah] is_a: GO:0018024 ! histone-lysine N-methyltransferase activity [Term] id: GO:0046975 name: histone methyltransferase activity (H3-K36 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [GOC:ai] synonym: "histone lysine N-methyltransferase activity (H3-K36 specific)" EXACT [] synonym: "histone methylase activity (H3-K36 specific)" EXACT [GOC:mah] is_a: GO:0018024 ! histone-lysine N-methyltransferase activity [Term] id: GO:0046976 name: histone methyltransferase activity (H3-K27 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein." [GOC:ai] synonym: "histone lysine N-methyltransferase activity (H3-K27 specific)" EXACT [] synonym: "histone methylase activity (H3-K27 specific)" EXACT [GOC:mah] is_a: GO:0018024 ! histone-lysine N-methyltransferase activity [Term] id: GO:0046977 name: TAP binding namespace: molecular_function def: "Interacting selectively and non-covalently with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2." [PMID:11133832] is_a: GO:0005515 ! protein binding [Term] id: GO:0046978 name: TAP1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] is_a: GO:0046977 ! TAP binding [Term] id: GO:0046979 name: TAP2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] is_a: GO:0046977 ! TAP binding [Term] id: GO:0046980 name: tapasin binding namespace: molecular_function def: "Interacting selectively and non-covalently with tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules." [PMID:12594855] is_a: GO:0005515 ! protein binding [Term] id: GO:0046981 name: beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." [GOC:bf, PMID:12130631, PMID:12130651] synonym: "UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [] is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0046982 name: protein heterodimerization activity namespace: molecular_function def: "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] is_a: GO:0046983 ! protein dimerization activity [Term] id: GO:0046983 name: protein dimerization activity namespace: molecular_function def: "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0005515 ! protein binding [Term] id: GO:0046984 name: regulation of hemoglobin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] synonym: "regulation of haemoglobin biosynthesis" EXACT [] synonym: "regulation of haemoglobin biosynthetic process" EXACT [] synonym: "regulation of hemoglobin anabolism" EXACT [] synonym: "regulation of hemoglobin biosynthesis" EXACT [] synonym: "regulation of hemoglobin formation" EXACT [] synonym: "regulation of hemoglobin synthesis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0042541 ! hemoglobin biosynthetic process [Term] id: GO:0046985 name: positive regulation of hemoglobin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] synonym: "activation of hemoglobin biosynthetic process" NARROW [] synonym: "positive regulation of haemoglobin biosynthesis" EXACT [] synonym: "positive regulation of haemoglobin biosynthetic process" EXACT [] synonym: "positive regulation of hemoglobin anabolism" EXACT [] synonym: "positive regulation of hemoglobin biosynthesis" EXACT [] synonym: "positive regulation of hemoglobin formation" EXACT [] synonym: "positive regulation of hemoglobin synthesis" EXACT [] synonym: "stimulation of hemoglobin biosynthetic process" NARROW [] synonym: "up regulation of hemoglobin biosynthetic process" EXACT [] synonym: "up-regulation of hemoglobin biosynthetic process" EXACT [] synonym: "upregulation of hemoglobin biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process is_a: GO:0051247 ! positive regulation of protein metabolic process relationship: positively_regulates GO:0042541 ! hemoglobin biosynthetic process [Term] id: GO:0046986 name: negative regulation of hemoglobin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] synonym: "down regulation of hemoglobin biosynthetic process" EXACT [] synonym: "down-regulation of hemoglobin biosynthetic process" EXACT [] synonym: "downregulation of hemoglobin biosynthetic process" EXACT [] synonym: "inhibition of hemoglobin biosynthetic process" NARROW [] synonym: "negative regulation of haemoglobin biosynthesis" EXACT [] synonym: "negative regulation of haemoglobin biosynthetic process" EXACT [] synonym: "negative regulation of hemoglobin anabolism" EXACT [] synonym: "negative regulation of hemoglobin biosynthesis" EXACT [] synonym: "negative regulation of hemoglobin formation" EXACT [] synonym: "negative regulation of hemoglobin synthesis" EXACT [] is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0042541 ! hemoglobin biosynthetic process [Term] id: GO:0046987 name: N-acetyllactosamine beta-1,3-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570] synonym: "galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity" EXACT [] is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0046988 name: asioloorosomucoid beta-1,3-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570] is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0046989 name: galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570] is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0046990 name: N-hydroxyarylamine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine." [EC:2.3.1.118, MetaCyc:2.3.1.118-RXN] subset: gosubset_prok synonym: "acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity" EXACT [EC:2.3.1.118] synonym: "arylhydroxamate N,O-acetyltransferase activity" EXACT [EC:2.3.1.118] synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" EXACT [EC:2.3.1.118] xref: EC:2.3.1.118 xref: MetaCyc:2.3.1.118-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0046992 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y." [GOC:ai] comment: Note that enzymes of class EC:1.21.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" NARROW [] xref: EC:1.21 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0046993 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen." [GOC:ai] subset: gosubset_prok xref: EC:1.21.3 is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond [Term] id: GO:0046994 name: oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound." [GOC:jl] subset: gosubset_prok xref: EC:1.12.5 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0046995 name: oxidoreductase activity, acting on hydrogen as donor, with other known acceptors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound." [GOC:ai] subset: gosubset_prok xref: EC:1.12.98 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0046996 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated." [GOC:mah] xref: EC:1.14.21 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0046997 name: oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl] subset: gosubset_prok xref: EC:1.5.8 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0046998 name: (S)-usnate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH." [EC:1.1.1.199, RHEA:21879] synonym: "L-usnic acid dehydrogenase activity" EXACT [EC:1.1.1.199] synonym: "reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)" EXACT [EC:1.1.1.199] xref: EC:1.1.1.199 xref: KEGG:R07345 xref: MetaCyc:1.1.1.199-RXN xref: RHEA:21879 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0046999 name: regulation of conjugation namespace: biological_process def: "Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual." [GOC:ai] subset: gosubset_prok is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0000746 ! conjugation [Term] id: GO:0047000 name: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH." [EC:1.1.1.126, RHEA:15112] synonym: "2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.126] synonym: "2-keto-3-deoxy-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.126] xref: EC:1.1.1.126 xref: KEGG:R01543 xref: MetaCyc:1.1.1.126-RXN xref: RHEA:15112 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047001 name: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate." [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN] synonym: "2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxygluconate 5-dehydrogenase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.127] xref: EC:1.1.1.127 xref: MetaCyc:1.1.1.127-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047002 name: L-arabinitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinitol + NAD(+) = L-ribulose + H(+) + NADH." [EC:1.1.1.13, RHEA:21359] synonym: "L-arabinitol 2-dehydrogenase (ribulose forming) activity" EXACT [] xref: EC:1.1.1.13 xref: KEGG:R02441 xref: MetaCyc:1.1.1.13-RXN xref: RHEA:21359 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047003 name: dTDP-6-deoxy-L-talose 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.134, RHEA:23651] synonym: "dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)" EXACT [EC:1.1.1.134] synonym: "dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.134] synonym: "TDP-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134] synonym: "thymidine diphospho-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134] xref: EC:1.1.1.134 xref: KEGG:R02776 xref: MetaCyc:1.1.1.134-RXN xref: RHEA:23651 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047004 name: UDP-N-acetylglucosamine 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate." [EC:1.1.1.136, RHEA:13328] synonym: "UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.136] synonym: "UDP-GLcNAc dehydrogenase activity" EXACT [EC:1.1.1.136] synonym: "UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.136] synonym: "UDPacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136] synonym: "uridine diphosphoacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136] xref: EC:1.1.1.136 xref: KEGG:R00421 xref: MetaCyc:1.1.1.136-RXN xref: RHEA:13328 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047005 name: 16-alpha-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid." [EC:1.1.1.147, MetaCyc:1.1.1.147-RXN] synonym: "16alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.147] synonym: "16alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.147] synonym: "16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity" EXACT [EC:1.1.1.147] xref: EC:1.1.1.147 xref: MetaCyc:1.1.1.147-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047006 name: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] subset: gosubset_prok synonym: "20alpha-HSD" RELATED [EC:1.1.1.149] synonym: "20alpha-HSDH" RELATED [EC:1.1.1.149] synonym: "20alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.149] synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149] synonym: "20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" BROAD [EC:1.1.1.149] xref: EC:1.1.1.149 xref: MetaCyc:1.1.1.149-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047007 name: pregnan-21-ol dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al." [EC:1.1.1.150, RHEA:11451] synonym: "21-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.50] synonym: "21-hydroxysteroid:NAD+ 21-oxidoreductase activity" BROAD [EC:1.1.1.150] xref: EC:1.1.1.150 xref: KEGG:R03043 xref: MetaCyc:1.1.1.150-RXN xref: RHEA:11451 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047008 name: pregnan-21-ol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al." [EC:1.1.1.151, RHEA:23715] synonym: "21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.151] synonym: "21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity" BROAD [EC:1.1.1.151] synonym: "21-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.151] synonym: "21-hydroxysteroid dehydrogenase (NADP+) activity" BROAD [EC:1.1.1.151] synonym: "21-hydroxysteroid:NADP+ 21-oxidoreductase activity" BROAD [EC:1.1.1.151] synonym: "NADP-21-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.151] xref: EC:1.1.1.151 xref: KEGG:R03044 xref: MetaCyc:1.1.1.151-RXN xref: RHEA:23715 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047009 name: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione." [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN] synonym: "3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] synonym: "3alpha-hydroxy-5beta-steroid dehydrogenase activity" EXACT [EC:1.1.1.152] synonym: "3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.152] synonym: "etiocholanolone 3-alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] synonym: "etiocholanolone 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] xref: EC:1.1.1.152 xref: MetaCyc:1.1.1.152-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047010 name: hydroxycyclohexanecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH." [EC:1.1.1.166, RHEA:10519] synonym: "(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity" EXACT [EC:1.1.1.166] synonym: "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.166] synonym: "dihydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.166] xref: EC:1.1.1.166 xref: KEGG:R05315 xref: MetaCyc:1.1.1.166-RXN xref: RHEA:10519 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047011 name: 2-dehydropantolactone reductase (A-specific) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN] synonym: "(R)-pantolactone:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.1.1.168] synonym: "2-dehydropantoyl-lactone reductase (A-specific) activity" EXACT [EC:1.1.1.168] synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.168] synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] xref: EC:1.1.1.168 xref: MetaCyc:1.1.1.168-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047012 name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one." [EC:1.1.1.170, MetaCyc:1.1.1.170-RXN] synonym: "3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" EXACT [] synonym: "3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [EC:1.1.1.170] synonym: "3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity" RELATED [EC:1.1.1.170] synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] synonym: "sterol 4-alpha-carboxylic decarboxylase activity" RELATED [EC:1.1.1.170] xref: EC:1.1.1.170 xref: MetaCyc:1.1.1.170-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047013 name: cholate 12-alpha dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH." [EC:1.1.1.176, RHEA:14132] subset: gosubset_prok synonym: "12-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] synonym: "12alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.176] synonym: "12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] synonym: "12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.176] synonym: "NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] synonym: "NADP-12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] xref: EC:1.1.1.176 xref: KEGG:R02793 xref: MetaCyc:1.1.1.176-RXN xref: RHEA:14132 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047014 name: glycerol-3-phosphate 1-dehydrogenase [NADP+] activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP(+) = D-glyceraldehyde 3-phosphate + H(+) + NADPH." [EC:1.1.1.177, RHEA:19776] synonym: "glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177] synonym: "glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.177] synonym: "L-glycerol 3-phosphate:NADP oxidoreductase activity" EXACT [EC:1.1.1.177] synonym: "NADPH-dependent glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177] synonym: "sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.177] xref: EC:1.1.1.177 xref: KEGG:R00845 xref: MetaCyc:1.1.1.177-RXN xref: RHEA:19776 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047015 name: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA." [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN] synonym: "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.178] synonym: "2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity" EXACT [EC:1.1.1.178] synonym: "2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.178] synonym: "2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.178] xref: EC:1.1.1.178 xref: MetaCyc:1.1.1.178-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047016 name: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one." [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN] synonym: "3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity" EXACT [EC:1.1.1.181] synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.181] synonym: "cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity" EXACT [EC:1.1.1.181] synonym: "cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.181] xref: EC:1.1.1.181 xref: MetaCyc:1.1.1.181-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047017 name: prostaglandin-F synthase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN] synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity" EXACT [EC:1.1.1.188] synonym: "NADPH-dependent prostaglandin D2 11-keto reductase activity" EXACT [EC:1.1.1.188] synonym: "PGD(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "PGD2 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "PGF synthetase activity" EXACT [EC:1.1.1.188] synonym: "PGF2alpha synthetase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin 11-keto reductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin D2-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin F synthase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin F synthetase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D(2) 11-reductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D(2) ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D2 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D2 11-reductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D2 ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-F synthetase activity" EXACT [EC:1.1.1.188] synonym: "reductase, 15-hydroxy-11-oxoprostaglandin" EXACT [EC:1.1.1.188] synonym: "synthetase, prostaglandin F2alpha" EXACT [EC:1.1.1.188] xref: EC:1.1.1.188 xref: MetaCyc:1.1.1.188-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047018 name: indole-3-acetaldehyde reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-ethanol + NAD(+) = (indol-3-yl)acetaldehyde + H(+) + NADH." [EC:1.1.1.190, RHEA:14876] synonym: "(indol-3-yl)ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190] synonym: "indole-3-ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190] synonym: "indoleacetaldehyde reductase activity" EXACT [EC:1.1.1.190] xref: EC:1.1.1.190 xref: KEGG:R02679 xref: MetaCyc:1.1.1.190-RXN xref: RHEA:14876 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047019 name: indole-3-acetaldehyde reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-ethanol + NADP(+) = (indol-3-yl)acetaldehyde + H(+) + NADPH." [EC:1.1.1.191, RHEA:17040] synonym: "(indol-3-yl)ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191] synonym: "indole-3-ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191] synonym: "indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.191] xref: EC:1.1.1.191 xref: KEGG:R02680 xref: MetaCyc:1.1.1.191-RXN xref: RHEA:17040 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047020 name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate." [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN] synonym: "(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.196] synonym: "15-hydroxy PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "15-hydroxyprostaglandin dehydrogenase (NADP)" EXACT [EC:1.1.1.196] synonym: "dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.196] synonym: "dehydrogenase, prostaglandin D2" EXACT [EC:1.1.1.196] synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] synonym: "NADP-linked prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "NADP-PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] synonym: "prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "prostaglandin-D 15-dehydrogenase (NADP(+)) activity" EXACT [EC:1.1.1.196] synonym: "prostaglandin-D 15-dehydrogenase (NADP)" EXACT [EC:1.1.1.196] synonym: "prostaglandin-D 15-dehydrogenase (NADP+) activity" EXACT [EC:1.1.1.196] xref: EC:1.1.1.196 xref: MetaCyc:1.1.1.196-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047021 name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH." [EC:1.1.1.197, RHEA:11639] synonym: "(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.197] synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] synonym: "type II 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.197] xref: EC:1.1.1.197 xref: KEGG:R04552 xref: MetaCyc:1.1.1.197-RXN xref: RHEA:11639 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047022 name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid." [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN] synonym: "7beta-hydroxysteroid dehydrogenase (NADP+)" EXACT [EC:1.1.1.201] synonym: "7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.201] synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201] synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201] xref: EC:1.1.1.201 xref: MetaCyc:1.1.1.201-RXN xref: Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+) is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047023 name: androsterone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione." [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN] synonym: "3(17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209] synonym: "3(or 17)-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209] synonym: "3(or 17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209] synonym: "3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity" BROAD [EC:1.1.1.209] xref: EC:1.1.1.209 xref: MetaCyc:1.1.1.209-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047024 name: 5alpha-androstane-3beta,17beta-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH." [EC:1.1.1.210, RHEA:16300] synonym: "3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210] synonym: "3-beta-HSD activity" RELATED [EC:1.1.1.210] synonym: "3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210] synonym: "3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" BROAD [EC:1.1.1.210] synonym: "3beta,20alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.210] synonym: "dehydrogenase, 3beta,20alpha-hydroxy steroid" BROAD [EC:1.1.1.210] synonym: "progesterone reductase activity" RELATED [EC:1.1.1.210] xref: EC:1.1.1.210 xref: KEGG:R04344 xref: MetaCyc:1.1.1.210-RXN xref: RHEA:16300 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047025 name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]." [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN] synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.212] synonym: "3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [] synonym: "3-oxoacyl-ACP reductase (NADH) activity" EXACT [] synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.1.1.212] synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.1.1.212] xref: EC:1.1.1.212 xref: MetaCyc:1.1.1.212-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047026 name: androsterone dehydrogenase (A-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.213, MetaCyc:1.1.1.213-RXN] synonym: "3-alpha-hydroxysteroid dehydrogenase (A-specific) activity" BROAD [EC:1.1.1.213] synonym: "3alpha-hydroxysteroid dehydrogenase (A-specific)" BROAD [EC:1.1.1.213] synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)" BROAD [EC:1.1.1.213] xref: EC:1.1.1.213 xref: MetaCyc:1.1.1.213-RXN xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific) is_a: GO:0047023 ! androsterone dehydrogenase activity [Term] id: GO:0047027 name: benzyl-2-methyl-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH." [EC:1.1.1.217, RHEA:16408] synonym: "benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.217] synonym: "benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.217] xref: EC:1.1.1.217 xref: KEGG:R04370 xref: MetaCyc:1.1.1.217-RXN xref: RHEA:16408 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047028 name: 6-pyruvoyltetrahydropterin 2'-reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin." [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN] subset: gosubset_prok synonym: "6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.220] synonym: "6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity" EXACT [EC:1.1.1.220] synonym: "6-pyruvoyl-tetrahydropterin 2'-reductase activity" EXACT [EC:1.1.1.220] synonym: "6-pyruvoyltetrahydropterin reductase activity" EXACT [EC:1.1.1.220] synonym: "6PPH4(2'-oxo) reductase activity" EXACT [EC:1.1.1.220] synonym: "pyruvoyl-tetrahydropterin reductase activity" EXACT [EC:1.1.1.220] xref: EC:1.1.1.220 xref: MetaCyc:1.1.1.220-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047029 name: (R)-4-hydroxyphenyllactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + (R)-3-(4-hydroxyphenyl)lactate = NAD(P)H + H+ + 3-(4-hydroxyphenyl)pyruvate." [EC:1.1.1.222, MetaCyc:1.1.1.222-RXN] synonym: "(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.222] synonym: "(R)-aromatic lactate dehydrogenase activity" EXACT [EC:1.1.1.222] synonym: "D-hydrogenase, D-aryllactate" EXACT [EC:1.1.1.222] xref: EC:1.1.1.222 xref: MetaCyc:1.1.1.222-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047030 name: 4-hydroxycyclohexanecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD(+) = 4-oxocyclohexanecarboxylate + H(+) + NADH." [EC:1.1.1.226, RHEA:17432] synonym: "trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.226] synonym: "trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.226] xref: EC:1.1.1.226 xref: KEGG:R04307 xref: MetaCyc:1.1.1.226-RXN xref: RHEA:17432 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047031 name: diethyl 2-methyl-3-oxosuccinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH." [EC:1.1.1.229, RHEA:21011] synonym: "diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.229] xref: EC:1.1.1.229 xref: KEGG:R04387 xref: MetaCyc:1.1.1.229-RXN xref: RHEA:21011 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047032 name: 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH." [EC:1.1.1.230, RHEA:20819] synonym: "3alpha-hydroxyglycyrrhetinate dehydrogenase activity" EXACT [EC:1.1.1.230] synonym: "3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.230] xref: EC:1.1.1.230 xref: KEGG:R04099 xref: MetaCyc:1.1.1.230-RXN xref: RHEA:20819 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047033 name: 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H(+) + NADPH." [EC:1.1.1.231, RHEA:21423] synonym: "(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.231] synonym: "NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.231] synonym: "NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity" EXACT [EC:1.1.1.231] synonym: "PG I2 dehydrogenase activity" EXACT [EC:1.1.1.231] synonym: "prostacyclin dehydrogenase activity" EXACT [EC:1.1.1.231] xref: EC:1.1.1.231 xref: KEGG:R03520 xref: MetaCyc:1.1.1.231-RXN xref: RHEA:21423 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047034 name: 15-hydroxyicosatetraenoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate." [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN] synonym: "(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity" EXACT [EC:1.1.1.232] synonym: "15-hydroxyeicosatetraenoate dehydrogenase activity" EXACT [EC:1.1.1.232] xref: EC:1.1.1.232 xref: MetaCyc:1.1.1.232-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047035 name: testosterone dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + testosterone = NADH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.239, MetaCyc:1.1.1.239-RXN] synonym: "3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.239] synonym: "3alpha(17beta)-HSD" RELATED [EC:1.1.1.239] synonym: "3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)" BROAD [EC:1.1.1.239] synonym: "3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.239] synonym: "3alpha,17beta-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.239] xref: EC:1.1.1.239 xref: MetaCyc:1.1.1.239-RXN xref: Wikipedia:3alpha(17beta)-hydroxysteroid_dehydrogenase_(NAD+) is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047036 name: codeinone reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: codeine + NADP(+) = codeinone + H(+) + NADPH." [EC:1.1.1.247, RHEA:19212] synonym: "codeine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.247] xref: EC:1.1.1.247 xref: KEGG:R05124 xref: MetaCyc:1.1.1.247-RXN xref: RHEA:19212 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047037 name: salutaridine reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine." [EC:1.1.1.248, RHEA:10111] synonym: "salutaridinol:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.248] xref: EC:1.1.1.248 xref: KEGG:R04697 xref: MetaCyc:1.1.1.248-RXN xref: RHEA:10111 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047038 name: D-arabinitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH." [EC:1.1.1.250, RHEA:17392] synonym: "D-arabinitol 2-dehydrogenase (ribulose-forming) activity" EXACT [EC:1.1.1.250] synonym: "D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)" EXACT [EC:1.1.1.250] xref: EC:1.1.1.250 xref: KEGG:R07134 xref: MetaCyc:1.1.1.250-RXN xref: RHEA:17392 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047039 name: tetrahydroxynaphthalene reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol." [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN] synonym: "scytalone:NADP+ delta5-oxidoreductase activity" EXACT [EC:1.1.1.252] synonym: "T4HN reductase activity" EXACT [EC:1.1.1.252] xref: EC:1.1.1.252 xref: MetaCyc:1.1.1.252-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047040 name: pteridine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 H(+) + 2 NADPH." [EC:1.5.1.33, RHEA:19512] comment: Note that this function was formerly EC:1.1.1.253. synonym: "5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.33] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "pteridine reductase 1 activity" NARROW [EC:1.5.1.33e] synonym: "PTR1" RELATED [EC:1.5.1.33] synonym: "ptr1 activity" NARROW [EC:1.5.1.33e] xref: EC:1.5.1.33 xref: KEGG:R01812 xref: MetaCyc:1.1.1.253-RXN xref: RHEA:19512 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047041 name: (S)-carnitine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH." [EC:1.1.1.254, RHEA:11559] synonym: "(S)-carnitine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.254] synonym: "D-carnitine dehydrogenase activity" EXACT [EC:1.1.1.254] xref: EC:1.1.1.254 xref: KEGG:R01921 xref: MetaCyc:1.1.1.254-RXN xref: RHEA:11559 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047042 name: androsterone dehydrogenase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.50, MetaCyc:1.1.1.50-RXN] subset: gosubset_prok synonym: "3-alpha-HSD activity" RELATED [EC:1.1.1.50] synonym: "3-alpha-hydroxysteroid dehydrogenase (B-specific) activity" BROAD [EC:1.1.1.50] synonym: "3alpha-HSD" RELATED [EC:1.1.1.50] synonym: "3alpha-hydroxysteroid dehydrogenase (B-specific)" BROAD [EC:1.1.1.50] synonym: "3alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.50] synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)" BROAD [EC:1.1.1.50] synonym: "hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.50] synonym: "sterognost 3alpha" RELATED [EC:1.1.1.50] xref: EC:1.1.1.50 xref: MetaCyc:1.1.1.50-RXN xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(B-specific) is_a: GO:0047023 ! androsterone dehydrogenase activity [Term] id: GO:0047043 name: 3-alpha-hydroxycholanate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: lithocholate + NAD(+) = 3-oxo-5beta-cholanate + H(+) + NADH." [EC:1.1.1.52, RHEA:19588] synonym: "3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.52] synonym: "3alpha-hydroxycholanate dehydrogenase activity" EXACT [EC:1.1.1.52] synonym: "alpha-hydroxy-cholanate dehydrogenase activity" EXACT [EC:1.1.1.52] xref: EC:1.1.1.52 xref: KEGG:R04139 xref: MetaCyc:1.1.1.52-RXN xref: RHEA:19588 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047044 name: androstan-3-alpha,17-beta-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+." [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN] subset: gosubset_prok synonym: "(R)-20-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53] synonym: "20beta-HSD" RELATED [EC:1.1.1.53] synonym: "20beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53] synonym: "3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53] synonym: "3alpha(or 20beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53] synonym: "3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.53] synonym: "3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity" BROAD [EC:1.1.1.53] synonym: "cortisone reductase activity" RELATED [EC:1.1.1.53] synonym: "dehydrogenase, 20beta-hydroxy steroid" BROAD [EC:1.1.1.53] synonym: "delta4-3-ketosteroid hydrogenase activity" BROAD [EC:1.1.1.53] synonym: "NADH-20beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53] xref: EC:1.1.1.53 xref: MetaCyc:1.1.1.53-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047045 name: testosterone 17-beta-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN] synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.64] synonym: "17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity" EXACT [EC:1.1.1.64] synonym: "NADP-dependent testosterone-17beta-oxidoreductase activity" EXACT [EC:1.1.1.64] synonym: "testosterone 17beta-dehydrogenase (NADP+)" EXACT [EC:1.1.1.64] xref: EC:1.1.1.64 xref: MetaCyc:1.1.1.64-RXN xref: Wikipedia:Testosterone_17beta-dehydrogenase_(NADP+) is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047046 name: homoisocitrate dehydrogenase activity namespace: molecular_function alt_id: GO:0047984 def: "Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate." [EC:1.1.1.155, EC:1.1.1.87, MetaCyc:1.1.1.87-RXN] comment: Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical. synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87] synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] synonym: "2-hydroxy-3-carboxyadipate dehydrogenase activity" EXACT [EC:1.1.1.87] synonym: "3-carboxy-2-hydroxyadipate dehydrogenase activity" EXACT [] synonym: "3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87] synonym: "3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] synonym: "homoisocitric dehydrogenase activity" EXACT [EC:1.1.1.87] xref: EC:1.1.1.87 xref: MetaCyc:1.1.1.87-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047047 name: oxaloglycolate reductase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate." [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN] synonym: "D-glycerate:NAD(P)+ oxidoreductase (carboxylating)" EXACT [EC:1.1.1.92] xref: EC:1.1.1.92 xref: MetaCyc:1.1.1.92-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047048 name: 3-hydroxybenzyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH." [EC:1.1.1.97, RHEA:22343] synonym: "3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.97] synonym: "m-hydroxybenzyl alcohol (NADP) dehydrogenase activity" EXACT [EC:1.1.1.97] synonym: "m-hydroxybenzyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.97] synonym: "m-hydroxybenzylalcohol dehydrogenase activity" EXACT [EC:1.1.1.97] xref: EC:1.1.1.97 xref: KEGG:R04136 xref: MetaCyc:1.1.1.97-RXN xref: RHEA:22343 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047049 name: (R)-2-hydroxy-fatty acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH." [EC:1.1.1.98, RHEA:15952] synonym: "(R)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT [] synonym: "(R)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.98] synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.98] synonym: "D-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.98] xref: EC:1.1.1.98 xref: KEGG:R03021 xref: MetaCyc:1.1.1.98-RXN xref: RHEA:15952 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047050 name: (S)-2-hydroxy-fatty acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH." [EC:1.1.1.99, RHEA:11387] synonym: "(S)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT [] synonym: "(S)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.99] synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.99] synonym: "dehydrogenase, L-2-hydroxy fatty acid" EXACT [EC:1.1.1.99] synonym: "L-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.99] xref: EC:1.1.1.99 xref: KEGG:R03022 xref: MetaCyc:1.1.1.99-RXN xref: RHEA:11387 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047051 name: D-lactate dehydrogenase (cytochrome c-553) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocytochrome C-553 + pyruvate." [EC:1.1.2.5, MetaCyc:1.1.2.5-RXN] synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" EXACT [EC:1.1.2.5] xref: EC:1.1.2.5 xref: MetaCyc:1.1.2.5-RXN is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0047052 name: (S)-stylopine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-cheilanthifoline + H(+) + NADPH + O(2) = (S)-stylopine + 2 H(2)O + NADP(+)." [EC:1.14.21.1, RHEA:13776] synonym: "(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.1] synonym: "(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.1] xref: EC:1.14.21.1 xref: KEGG:R04690 xref: MetaCyc:1.1.3.32-RXN xref: RHEA:13776 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: GO:0047053 name: (S)-cheilanthifoline synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-scoulerine + H(+) + NADPH + O(2) = (S)-cheilanthifoline + 2 H(2)O + NADP(+)." [EC:1.14.21.2, RHEA:20488] synonym: "(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity" EXACT [] synonym: "(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.2] xref: EC:1.14.21.2 xref: KEGG:R03834 xref: MetaCyc:1.14.21.2-RXN xref: RHEA:20488 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: GO:0047054 name: berbamunine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + R-N-methylcoclaurine + S-N-methylcoclaurine = 2 H2O + NADP+ + berbamunine." [EC:1.14.21.3, MetaCyc:1.1.3.34-RXN] synonym: "(S)-N-methylcoclaurine oxidase (C-O phenol-coupling) activity" EXACT [EC:1.14.21.3] synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (C-O phenol-coupling)" EXACT [EC:1.14.21.3] xref: EC:1.14.21.3 xref: MetaCyc:1.1.3.34-RXN is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: GO:0047055 name: salutaridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-reticuline + H(+) + NADPH + O(2) = 2 H(2)O + NADP(+) + salutaridine." [EC:1.14.21.4, RHEA:17716] synonym: "(R)-reticuline oxidase (C-C phenol-coupling) activity" EXACT [EC:1.14.21.4] synonym: "(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)" EXACT [EC:1.14.21.4] xref: EC:1.14.21.4 xref: KEGG:R04696 xref: MetaCyc:1.1.3.35-RXN xref: RHEA:17716 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: GO:0047056 name: (S)-canadine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + H(+) + NADPH + O(2) = (S)-canadine + 2 H(2)O + NADP(+)." [EC:1.14.21.5, RHEA:21459] synonym: "(S)-tetrahydroberberine synthase activity" EXACT [EC:1.14.21.5] synonym: "(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.5] synonym: "(S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.5] xref: EC:1.14.21.5 xref: KEGG:R04400 xref: MetaCyc:1.1.3.36-RXN xref: RHEA:21459 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated [Term] id: GO:0047057 name: vitamin-K-epoxide reductase (warfarin-sensitive) activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.1, MetaCyc:1.1.4.1-RXN] synonym: "2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.1] synonym: "phylloquinone epoxide reductase activity" EXACT [EC:1.1.4.1] synonym: "vitamin K1 epoxide reductase activity" NARROW [EC:1.1.4.1] xref: EC:1.1.4.1 xref: MetaCyc:1.1.4.1-RXN xref: Reactome:82285 "vitamin-K-epoxide reductase (warfarin-sensitive) activity" is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor [Term] id: GO:0047058 name: vitamin-K-epoxide reductase (warfarin-insensitive) activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.2, MetaCyc:1.1.4.2-RXN] synonym: "3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.2] synonym: "vitamin K 2,3-epoxide reductase activity" EXACT [EC:1.1.4.2] xref: EC:1.1.4.2 xref: MetaCyc:1.1.4.2-RXN is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor [Term] id: GO:0047059 name: polyvinyl-alcohol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: acceptor + polyvinyl alcohol = donor-H2 + oxidized polyvinyl alcohol." [EC:1.1.99.23] subset: gosubset_prok synonym: "polyvinyl-alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.23] synonym: "polyvinyl-alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.23] synonym: "PVA dehydrogenase activity" EXACT [EC:1.1.99.23] xref: EC:1.1.99.23 xref: MetaCyc:RXN-11316 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047060 name: (R)-pantolactone dehydrogenase (flavin) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2)." [EC:1.1.99.27, RHEA:21007] synonym: "(R)-pantolactone:acceptor oxidoreductase (flavin-containing)" EXACT [EC:1.1.99.27] synonym: "(R)-pantoyllactone dehydrogenase (flavin) activity" EXACT [EC:1.1.99.27] synonym: "2-dehydropantolactone reductase (flavin) activity" EXACT [EC:1.1.99.27] synonym: "2-dehydropantoyl-lactone reductase (flavin) activity" EXACT [EC:1.1.99.27] xref: EC:1.1.99.27 xref: KEGG:R03156 xref: MetaCyc:1.1.99.27-RXN xref: RHEA:21007 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047061 name: glucose-fructose oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone." [EC:1.1.99.28, RHEA:20640] subset: gosubset_prok synonym: "D-glucose:D-fructose oxidoreductase activity" EXACT [EC:1.1.99.28] xref: EC:1.1.99.28 xref: KEGG:R00874 xref: MetaCyc:1.1.99.28-RXN xref: RHEA:20640 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047062 name: trans-acenaphthene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH." [EC:1.10.1.1, RHEA:22187] synonym: "(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.10.1.1] synonym: "trans-1,2-acenaphthenediol dehydrogenase activity" EXACT [EC:1.10.1.1] xref: EC:1.10.1.1 xref: KEGG:R04059 xref: MetaCyc:1.10.1.1-RXN xref: RHEA:22187 is_a: GO:0016680 ! oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor [Term] id: GO:0047063 name: L-ascorbate-cytochrome-b5 reductase activity namespace: molecular_function def: "Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate." [EC:1.10.2.1, MetaCyc:1.10.2.1-RXN] synonym: "ascorbate-cytochrome b5 reductase activity" EXACT [EC:1.10.2.1] synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.10.2.1] xref: EC:1.10.2.1 xref: MetaCyc:1.10.2.1-RXN is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor [Term] id: GO:0047064 name: sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H(2)O." [EC:1.21.3.4, RHEA:24095] synonym: "sulochrin oxidase activity" EXACT [EC:1.21.3.4] synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)" EXACT [EC:1.21.3.4] xref: EC:1.21.3.4 xref: KEGG:R00060 xref: MetaCyc:1.10.3.7-RXN xref: RHEA:24095 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0047065 name: sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H(2)O." [EC:1.21.3.5, RHEA:22619] synonym: "sulochrin oxidase activity" BROAD [EC:1.21.3.5] synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)" EXACT [EC:1.21.3.5] xref: EC:1.21.3.5 xref: KEGG:R00061 xref: MetaCyc:1.10.3.8-RXN xref: RHEA:22619 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0047066 name: phospholipid-hydroperoxide glutathione peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN] synonym: "glutathione:lipid-hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.12] synonym: "hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12] synonym: "peroxidation-inhibiting protein activity" RELATED [EC:1.11.1.12] synonym: "peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)" EXACT [EC:1.11.1.12] synonym: "PHGPX" RELATED [EC:1.11.1.12] synonym: "phospholipid hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12] xref: EC:1.11.1.12 xref: MetaCyc:1.11.1.12-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047067 name: hydrogen:quinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone." [EC:1.12.5.1, RHEA:18644] subset: gosubset_prok synonym: "hydrogen-ubiquinone oxidoreductase activity" EXACT [EC:1.12.5.1] synonym: "hydrogen:menaquinone oxidoreductase activity" EXACT [EC:1.12.5.1] synonym: "membrane-bound hydrogenase activity" NARROW [EC:1.12.5.1] synonym: "quinone-reactive Ni/Fe-hydrogenase activity" RELATED [EC:1.12.5.1] xref: EC:1.12.5.1 xref: KEGG:R02965 xref: MetaCyc:1.12.5.1-RXN xref: RHEA:18644 is_a: GO:0046994 ! oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor [Term] id: GO:0047068 name: N5,N10-methenyltetrahydromethanopterin hydrogenase activity namespace: molecular_function alt_id: GO:0016947 def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H(+)." [EC:1.12.98.2, RHEA:20020] subset: gosubset_prok synonym: "5,10-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H(2)-dependent methylene-H(4)MPT dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H2-dependent methylene-H4MPT dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] synonym: "hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] synonym: "hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] synonym: "N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2] synonym: "N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [] synonym: "nonmetal hydrogenase activity" RELATED [EC:1.12.98.2] xref: EC:1.12.98.2 xref: KEGG:R04455 xref: MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN xref: RHEA:20020 is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors [Term] id: GO:0047069 name: 7,8-dihydroxykynurenate 8,8a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroxykynurenate + O(2) = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)." [EC:1.13.11.10, RHEA:23403] synonym: "7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity" EXACT [EC:1.13.11.10] synonym: "7,8-dihydroxykynurenate oxygenase activity" EXACT [EC:1.13.11.10] synonym: "7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.10] xref: EC:1.13.11.10 xref: KEGG:R03253 xref: MetaCyc:1.13.11.10-RXN xref: RHEA:23403 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047070 name: 3-carboxyethylcatechol 2,3-dioxygenase activity namespace: molecular_function alt_id: GO:0008669 def: "Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate." [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN] synonym: "2,3-dihydroxy-beta-phenylpropionate oxygenase activity" EXACT [EC:1.13.11.16] synonym: "2,3-dihydroxy-beta-phenylpropionic dioxygenase activity" EXACT [EC:1.13.11.16] synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.16] synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.16] xref: EC:1.13.11.16 xref: MetaCyc:1.13.11.16-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047071 name: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)." [EC:1.13.11.25, RHEA:21355] synonym: "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.25] synonym: "3-alkylcatechol 2,3-dioxygenase activity" EXACT [EC:1.13.11.25] synonym: "steroid 4,5-dioxygenase activity" BROAD [EC:1.13.11.25] xref: EC:1.13.11.25 xref: KEGG:R04597 xref: MetaCyc:1.13.11.25-RXN xref: RHEA:21355 xref: UM-BBD_reactionID:r1151 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047072 name: 2,3-dihydroxybenzoate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-carboxy-cis,cis-muconate + 2 H(+)." [EC:1.13.11.28, RHEA:15372] synonym: "2,3-dihydroxybenzoate 2,3-oxygenase activity" EXACT [EC:1.13.11.28] synonym: "2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.28] xref: EC:1.13.11.28 xref: KEGG:R01506 xref: MetaCyc:1.13.11.28-RXN xref: RHEA:15372 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047073 name: 2,4'-dihydroxyacetophenone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O(2) = 4-hydroxybenzoate + formate + 2 H(+)." [EC:1.13.11.41, RHEA:24419] subset: gosubset_prok synonym: "(4-hydroxybenzoyl)methanol oxygenase activity" EXACT [EC:1.13.11.41] synonym: "2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.13.11.41] xref: EC:1.13.11.41 xref: KEGG:R01305 xref: MetaCyc:1.13.11.41-RXN xref: RHEA:24419 xref: UM-BBD_reactionID:r1410 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047074 name: 4-hydroxycatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." [EC:1.13.11.-, MetaCyc:R308-RXN] xref: EC:1.13.11.- xref: MetaCyc:RXN-10137 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047075 name: 2,5-dihydroxypyridine 5,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate." [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN] synonym: "2,5-dihydroxypyridine oxygenase activity" EXACT [EC:1.13.11.9] synonym: "2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity" EXACT [EC:1.13.11.9] synonym: "pyridine-2,5-diol dioxygenase activity" EXACT [EC:1.13.11.9] xref: EC:1.13.11.9 xref: MetaCyc:1.13.11.9-RXN xref: UM-BBD_reactionID:r1443 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047077 name: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN] synonym: "firefly luciferase activity" EXACT [EC:1.13.12.7] synonym: "firefly luciferin luciferase activity" EXACT [EC:1.13.12.7] synonym: "luciferase (firefly luciferin)" EXACT [EC:1.13.12.7] synonym: "luciferase activity" BROAD [EC:1.13.12.7] synonym: "Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)" EXACT [EC:1.13.12.7] synonym: "Photinus pyralis luciferase activity" EXACT [EC:1.13.12.7] synonym: "Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)" EXACT [EC:1.13.12.7] synonym: "Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)" EXACT [EC:1.13.12.7] xref: EC:1.13.12.7 xref: MetaCyc:1.13.12.7-RXN is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0047078 name: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate." [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN] subset: gosubset_prok synonym: "(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] synonym: "1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [] synonym: "3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.47] synonym: "3-hydroxy-4(1H)-one, 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] synonym: "3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] synonym: "quinoline-3,4-diol 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] xref: EC:1.13.11.47 xref: MetaCyc:1.13.11.47-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047079 name: pyrimidine-deoxynucleoside 1'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = 2-deoxy-D-ribono-1,4-lactone + CO(2) + succinate + uracil." [EC:1.14.11.10, RHEA:23319] synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)" EXACT [EC:1.14.11.10] synonym: "deoxyuridine-uridine 1'-dioxygenase activity" EXACT [EC:1.14.11.10] synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity" EXACT [EC:1.14.11.10] xref: EC:1.14.11.10 xref: KEGG:R02486 xref: MetaCyc:1.14.11.10-RXN xref: RHEA:23319 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0047080 name: pyrimidine-deoxynucleoside 2'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = CO(2) + succinate + uridine." [EC:1.14.11.3, RHEA:21079] synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.11.3] synonym: "deoxyuridine 2'-dioxygenase activity" EXACT [EC:1.14.11.3] synonym: "deoxyuridine 2'-hydroxylase activity" EXACT [EC:1.14.11.3] synonym: "pyrimidine deoxyribonucleoside 2'-hydroxylase activity" EXACT [EC:1.14.11.3] synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity" EXACT [EC:1.14.11.3] synonym: "thymidine 2'-dioxygenase activity" NARROW [EC:1.14.11.3] synonym: "thymidine 2'-hydroxylase activity" NARROW [EC:1.14.11.3] synonym: "thymidine 2-oxoglutarate dioxygenase activity" NARROW [EC:1.14.11.3] synonym: "thymidine dioxygenase activity" NARROW [EC:1.14.11.3] xref: EC:1.14.11.3 xref: KEGG:R01879 xref: MetaCyc:1.14.11.3-RXN xref: RHEA:21079 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0047081 name: 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NAD(P)H + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NAD(P)+ + 2-(acetamidomethylene)succinate." [EC:1.14.12.4, MetaCyc:1.14.12.4-RXN] synonym: "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" EXACT [EC:1.14.12.4] synonym: "3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.4] synonym: "3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" EXACT [EC:1.14.12.4] synonym: "methylhydroxypyridine carboxylate dioxygenase activity" EXACT [EC:1.14.12.4] synonym: "methylhydroxypyridinecarboxylate oxidase activity" EXACT [EC:1.14.12.4] xref: EC:1.14.12.4 xref: MetaCyc:1.14.12.4-RXN is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0047082 name: 3,9-dihydroxypterocarpan 6a-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H(+) + NADPH + O(2) = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(2)O + NADP(+). (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol." [EC:1.14.13.28, RHEA:15324] synonym: "(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)" EXACT [EC:1.14.13.28] synonym: "3,9-dihydroxypterocarpan 6a-hydroxylase activity" EXACT [] synonym: "3,9-dihydroxypterocarpan 6alpha-monooxygenase (erroneous)" EXACT [EC:1.14.13.28] xref: EC:1.14.13.28 xref: KEGG:R03452 xref: MetaCyc:RXN-4505 xref: RHEA:15324 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047083 name: 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate." [EC:1.14.13.36, MetaCyc:1.14.13.36-RXN] synonym: "5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity" EXACT [] synonym: "coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity" EXACT [EC:1.14.13.36] synonym: "trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.36] xref: EC:1.14.13.36 xref: MetaCyc:1.14.13.36-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047084 name: methyltetrahydroprotoberberine 14-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine." [EC:1.14.13.37, MetaCyc:1.14.13.37-RXN] synonym: "(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity" EXACT [EC:1.14.13.37] synonym: "(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity" EXACT [EC:1.14.13.37] synonym: "(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)" EXACT [EC:1.14.13.37] synonym: "methyltetrahydroprotoberberine 14-hydroxylase activity" EXACT [] xref: EC:1.14.13.37 xref: MetaCyc:1.14.13.37-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047085 name: hydroxyphenylacetonitrile 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H(+) + NADPH + O(2) = 4-hydroxymandelonitrile + H(2)O + NADP(+)." [EC:1.14.13.42, RHEA:23743] synonym: "4-hydroxyphenylacetonitrile hydroxylase activity" EXACT [EC:1.14.13.42] synonym: "4-hydroxyphenylacetonitrile monooxygenase activity" EXACT [] synonym: "4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.42] xref: EC:1.14.13.42 xref: KEGG:R02708 xref: MetaCyc:1.14.13.42-RXN xref: RHEA:23743 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047086 name: ketosteroid monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate." [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN] synonym: "17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)" EXACT [EC:1.14.13.54] synonym: "androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54] synonym: "ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54] synonym: "progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)" EXACT [EC:1.14.13.54] synonym: "steroid-ketone monooxygenase activity" EXACT [EC:1.14.13.54] xref: EC:1.14.13.54 xref: MetaCyc:1.14.13.54-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047087 name: protopine 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + protopine = 6-hydroxyprotopine + H(2)O + NADP(+)." [EC:1.14.13.55, RHEA:22647] synonym: "protopine 6-hydroxylase activity" EXACT [] synonym: "protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.55] xref: EC:1.14.13.55 xref: KEGG:R04699 xref: MetaCyc:1.14.13.55-RXN xref: RHEA:22647 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047088 name: dihydrosanguinarine 10-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrosanguinarine + H(+) + NADPH + O(2) = 10-hydroxydihydrosanguinarine + H(2)O + NADP(+)." [EC:1.14.13.56, RHEA:10531] synonym: "dihydrosanguinarine 10-hydroxylase activity" EXACT [] synonym: "dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)" EXACT [EC:1.14.13.56] xref: EC:1.14.13.56 xref: KEGG:R04702 xref: MetaCyc:1.14.13.56-RXN xref: RHEA:10531 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047089 name: dihydrochelirubine 12-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrochelirubine + H(+) + NADPH + O(2) = 12-hydroxydihydrochelirubine + H(2)O + NADP(+)." [EC:1.14.13.57, RHEA:10159] synonym: "dihydrochelirubine 12-hydroxylase activity" EXACT [] synonym: "dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.57] xref: EC:1.14.13.57 xref: KEGG:R04708 xref: MetaCyc:1.14.13.57-RXN xref: RHEA:10159 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047090 name: benzoyl-CoA 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + H(+) + NADPH + O(2) = 3-hydroxybenzoyl-CoA + H(2)O + NADP(+)." [EC:1.14.13.58, RHEA:23219] synonym: "benzoyl-CoA 3-hydroxylase activity" EXACT [] synonym: "benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.58] xref: EC:1.14.13.58 xref: KEGG:R02449 xref: MetaCyc:1.14.13.58-RXN xref: RHEA:23219 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047091 name: L-lysine 6-monooxygenase (NADPH) activity namespace: molecular_function alt_id: GO:0008739 def: "Catalysis of the reaction: L-lysine + NADPH + O(2) = N(6)-hydroxy-L-lysine + H(2)O + NADP(+)." [EC:1.14.13.59, RHEA:23231] comment: Note that EC:1.13.12.10 was merged into this term. subset: gosubset_prok synonym: "L-lysine 6-monooxygenase activity" EXACT [] synonym: "L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.59] synonym: "lysine N(6)-hydroxylase activity" EXACT [EC:1.14.13.59] synonym: "lysine N6-hydroxylase activity" EXACT [] xref: EC:1.14.13.59 xref: KEGG:R00448 xref: MetaCyc:1.14.13.59-RXN xref: RHEA:23231 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047092 name: 27-hydroxycholesterol 7-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [EC:1.14.13.60, MetaCyc:1.14.13.60-RXN] synonym: "27-hydroxycholesterol 7-alpha-hydroxylase activity" EXACT [EC:1.14.13.60] synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT [] synonym: "27-hydroxycholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.60] synonym: "27-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.60] synonym: "27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.60] xref: EC:1.14.13.60 xref: MetaCyc:1.14.13.60-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047093 name: 4-hydroxyquinoline 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-4-ol = H(2)O + NAD(+) + quinoline-3,4-diol." [EC:1.14.13.62, RHEA:19328] synonym: "1-H-4-oxoquinoline 3-monooxygenase activity" EXACT [EC:1.14.13.62] synonym: "quinolin-4(1H)-one 3-monooxygenase activity" EXACT [EC:1.14.13.62] synonym: "quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)" EXACT [EC:1.14.13.62] xref: EC:1.14.13.62 xref: KEGG:R05154 xref: MetaCyc:1.14.13.62-RXN xref: RHEA:19328 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047094 name: 3-hydroxyphenylacetate 6-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate." [EC:1.14.13.63, MetaCyc:1.14.13.63-RXN] synonym: "3-hydroxyphenylacetate 6-monooxygenase activity" EXACT [EC:1.14.13.63] synonym: "3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.63] xref: EC:1.14.13.63 xref: MetaCyc:1.14.13.63-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047095 name: 2-hydroxycyclohexanone 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O(2) = 6-oxohexanoate + H(2)O + NADP(+)." [EC:1.14.13.66, RHEA:25172] synonym: "2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.13.66] xref: EC:1.14.13.66 xref: KEGG:R03281 xref: MetaCyc:1.14.13.66-RXN xref: RHEA:25172 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047096 name: androst-4-ene-3,17-dione monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O(2) = A + H(2)O + testololactone." [EC:1.14.99.12, RHEA:22699] synonym: "4-androstene-3,17-dione monooxygenase activity" EXACT [] synonym: "androst-4-ene-3,17-dione 17-oxidoreductase activity" EXACT [EC:1.14.99.12] synonym: "androst-4-ene-3,17-dione hydroxylase activity" EXACT [EC:1.14.99.12] synonym: "androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)" EXACT [EC:1.14.99.12] synonym: "androstene-3,17-dione hydroxylase activity" EXACT [] synonym: "androstenedione monooxygenase activity" EXACT [EC:1.14.99.12] xref: EC:1.14.99.12 xref: KEGG:R01833 xref: MetaCyc:1.14.99.12-RXN xref: RHEA:22699 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047097 name: phylloquinone monooxygenase (2,3-epoxidizing) activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + phylloquinone = 2,3-epoxyphylloquinone + A + H(2)O." [EC:1.14.99.20, RHEA:16748] synonym: "phylloquinone epoxidase activity" EXACT [EC:1.14.99.20] synonym: "phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.20] synonym: "vitamin K 2,3-epoxidase activity" EXACT [EC:1.14.99.20] synonym: "vitamin K epoxidase activity" EXACT [EC:1.14.99.20] synonym: "vitamin K1 epoxidase activity" EXACT [EC:1.14.99.20] xref: EC:1.14.99.20 xref: KEGG:R03510 xref: MetaCyc:1.14.99.20-RXN xref: RHEA:16748 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047098 name: Latia-luciferin monooxygenase (demethylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin." [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN] synonym: "Latia luciferin monooxygenase (demethylating)" EXACT [EC:1.14.99.21] synonym: "Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.99.21] synonym: "luciferase (Latia luciferin)" EXACT [EC:1.14.99.21] xref: EC:1.14.99.21 xref: MetaCyc:1.14.99.21-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0047099 name: CDP-4-dehydro-6-deoxyglucose reductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose." [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN] synonym: "CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.17.1.1] synonym: "CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity" EXACT [EC:1.17.1.1] synonym: "CDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.17.1.1] synonym: "CDP-4-keto-deoxy-glucose reductase activity" EXACT [EC:1.17.1.1] synonym: "cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity" EXACT [EC:1.17.1.1] synonym: "cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity" EXACT [EC:1.17.1.1] synonym: "NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity" EXACT [EC:1.17.1.1] xref: EC:1.17.1.1 xref: MetaCyc:1.17.1.1-RXN is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0047100 name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate." [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN] synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.13] synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13] synonym: "glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13] synonym: "NADP-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] synonym: "NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] synonym: "NADP-triose phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] synonym: "triosephosphate dehydrogenase (NADP(+)) activity" EXACT [EC:1.2.1.13] synonym: "triosephosphate dehydrogenase (NADP)" EXACT [EC:1.2.1.13] synonym: "triosephosphate dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.13] xref: EC:1.2.1.13 xref: MetaCyc:1.2.1.13-RXN is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: GO:0047101 name: 2-oxoisovalerate dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA." [EC:1.2.1.25, MetaCyc:1.2.1.25-RXN] synonym: "2-oxoisovalerate dehydrogenase activity" EXACT [EC:1.2.1.25] synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" EXACT [EC:1.2.1.25] xref: EC:1.2.1.25 xref: MetaCyc:1.2.1.25-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047102 name: aminomuconate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate." [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN] synonym: "2-aminomuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity" EXACT [EC:1.2.1.32] synonym: "2-hydroxymuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "2-hydroxymuconic acid semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "2-hydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] xref: EC:1.2.1.32 xref: MetaCyc:1.2.1.32-RXN xref: Reactome:82529 "aminomuconate-semialdehyde dehydrogenase activity" xref: UM-BBD_reactionID:r1434 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047103 name: 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate." [EC:1.2.1.40, MetaCyc:1.2.1.40-RXN] synonym: "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity" EXACT [EC:1.2.1.40] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity" EXACT [EC:1.2.1.40] synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity" EXACT [EC:1.2.1.40] synonym: "cholestanetriol-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] synonym: "THAL-NAD oxidoreductase activity" EXACT [EC:1.2.1.40] synonym: "trihydroxydeoxycoprostanal dehydrogenase activity" EXACT [EC:1.2.1.40] xref: EC:1.2.1.40 xref: MetaCyc:1.2.1.40-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047104 name: hexadecanal dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + NAD(+) + palmitaldehyde = H(+) + NADH + palmitoyl-CoA." [EC:1.2.1.42, RHEA:19708] synonym: "fatty acyl-CoA reductase activity" BROAD [EC:1.2.1.42] synonym: "hexadecanal:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.42] xref: EC:1.2.1.42 xref: KEGG:R01277 xref: MetaCyc:1.2.1.42-RXN xref: RHEA:19708 xref: UM-BBD_reactionID:r1374 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047105 name: 4-trimethylammoniobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate." [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN] synonym: "4-N-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47] synonym: "4-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47] synonym: "4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.47] xref: EC:1.2.1.47 xref: MetaCyc:1.2.1.47-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047106 name: 4-hydroxyphenylacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate." [EC:1.2.1.53, MetaCyc:1.2.1.53-RXN] synonym: "4-HPAL dehydrogenase activity" EXACT [EC:1.2.1.53] synonym: "4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.53] xref: EC:1.2.1.53 xref: MetaCyc:1.2.1.53-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047107 name: gamma-guanidinobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-guanidinobutanal + H(2)O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH." [EC:1.2.1.54, RHEA:14384] synonym: "4-guanidinobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.54] synonym: "4-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54] synonym: "alpha-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54] synonym: "GBAL dehydrogenase activity" EXACT [EC:1.2.1.54] xref: EC:1.2.1.54 xref: KEGG:R03177 xref: MetaCyc:1.2.1.54-RXN xref: RHEA:14384 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047108 name: (R)-3-hydroxyacid-ester dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH." [EC:1.1.1.279, RHEA:24355] comment: Note that this term was EC:1.2.1.55. synonym: "(R)-3-hydroxyacid ester dehydrogenase activity" EXACT [] synonym: "3-oxo ester (R)-reductase activity" EXACT [EC:1.1.1.279] synonym: "ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.279] xref: EC:1.1.1.279 xref: KEGG:R04105 xref: MetaCyc:1.2.1.55-RXN xref: RHEA:24355 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047109 name: (S)-3-hydroxyacid-ester dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH." [EC:1.1.1.280, RHEA:18272] comment: Note that this term was EC:1.2.1.56. synonym: "(S)-3-hydroxyacid ester dehydrogenase activity" EXACT [] synonym: "3-oxo ester (S)-reductase activity" EXACT [EC:1.1.1.280] synonym: "ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.280] xref: EC:1.1.1.280 xref: KEGG:R04106 xref: MetaCyc:1.2.1.56-RXN xref: RHEA:18272 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047110 name: phenylglyoxylate dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO(2) + NADH." [EC:1.2.1.58, RHEA:10375] synonym: "phenylglyoxylate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.58] xref: EC:1.2.1.58 xref: KEGG:R02450 xref: MetaCyc:1.2.1.58-RXN xref: RHEA:10375 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047111 name: formate dehydrogenase (cytochrome-c-553) activity namespace: molecular_function def: "Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2." [EC:1.2.2.3, MetaCyc:1.2.2.3-RXN] synonym: "formate dehydrogenase (cytochrome c-553)" EXACT [EC:1.2.2.3] synonym: "formate:ferricytochrome-c-553 oxidoreductase activity" EXACT [EC:1.2.2.3] xref: EC:1.2.2.3 xref: MetaCyc:1.2.2.3-RXN is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0047112 name: pyruvate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + O(2) + phosphate + pyruvate = acetyl phosphate + CO(2) + H(2)O(2)." [EC:1.2.3.3, RHEA:20851] subset: gosubset_prok synonym: "phosphate-dependent pyruvate oxidase activity" EXACT [EC:1.2.3.3] synonym: "pyruvate:oxygen 2-oxidoreductase (phosphorylating)" EXACT [EC:1.2.3.3] synonym: "pyruvic oxidase activity" EXACT [EC:1.2.3.3] xref: EC:1.2.3.3 xref: KEGG:R00207 xref: MetaCyc:1.2.3.3-RXN xref: RHEA:20851 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0047113 name: aldehyde dehydrogenase (pyrroloquinoline-quinone) activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acceptor + an aldehyde = donor-H2 + an acid." [EC:1.2.99.3, MetaCyc:1.2.99.3-RXN] subset: gosubset_prok synonym: "aldehyde dehydrogenase (acceptor) activity" EXACT [EC:1.2.99.3] synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" EXACT [EC:1.2.99.3] xref: EC:1.2.99.3 xref: MetaCyc:1.2.99.3-RXN is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0047114 name: kynurenate-7,8-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH." [EC:1.3.1.18, RHEA:22251] synonym: "7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity" EXACT [EC:1.3.1.18] synonym: "7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.18] synonym: "7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity" EXACT [EC:1.3.1.18] xref: EC:1.3.1.18 xref: KEGG:R03251 xref: MetaCyc:1.3.1.18-RXN xref: RHEA:22251 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047115 name: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol." [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN] subset: gosubset_prok synonym: "dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.20] synonym: "trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.20] xref: EC:1.3.1.20 xref: MetaCyc:1.3.1.20-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047116 name: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol." [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN] synonym: "(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.25] synonym: "2-hydro-1,2-dihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.25] synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.25] synonym: "DHB dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "DHBDH activity" EXACT [EC:1.3.1.25] synonym: "dihydrodihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25] xref: EC:1.3.1.25 xref: MetaCyc:1.3.1.25-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047117 name: enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.39, MetaCyc:1.3.1.39-RXN] synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.3.1.39] synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity" EXACT [] synonym: "enoyl-ACP reductase (NADPH, A-specific) activity" EXACT [] synonym: "enoyl-ACp reductase activity" EXACT [EC:1.3.1.39] synonym: "enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.39] synonym: "enoyl-acyl-carrier-protein reductase (NADPH, A-specific)" EXACT [EC:1.3.1.39] xref: EC:1.3.1.39 xref: MetaCyc:1.3.1.39-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047118 name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH." [EC:1.3.1.40, RHEA:24271] synonym: "2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.40] synonym: "2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.40] xref: EC:1.3.1.40 xref: KEGG:R03463 xref: MetaCyc:1.3.1.40-RXN xref: RHEA:24271 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047119 name: 2-methyl-branched-chain-enoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + NAD(+) = 2-methylbut-2-enoyl-CoA + H(+) + NADH." [EC:1.3.1.52, RHEA:24535] synonym: "2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase activity" EXACT [EC:1.3.1.52] xref: EC:1.3.1.52 xref: KEGG:R03169 xref: MetaCyc:1.3.1.52-RXN xref: RHEA:24535 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047120 name: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity namespace: molecular_function alt_id: GO:0018514 def: "Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO(2) + NADH." [EC:1.3.1.53, RHEA:10747] synonym: "(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53] synonym: "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.53] synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.53] synonym: "dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53] synonym: "terephthalate 1,2-cis-dihydrodiol dehydrogenase activity" EXACT [] xref: EC:1.3.1.53 xref: KEGG:R01633 xref: MetaCyc:1.3.1.53-RXN xref: RHEA:10747 xref: UM-BBD_reactionID:r0151 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047121 name: isoquinoline 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: A + H(2)O + isoquinoline = AH(2) + isoquinolin-1(2H)-one." [EC:1.3.99.16, RHEA:11591] subset: gosubset_prok synonym: "isoquinoline:acceptor 1-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.16] xref: EC:1.3.99.16 xref: KEGG:R05151 xref: MetaCyc:1.3.99.16-RXN xref: RHEA:11591 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047122 name: quinaldate 4-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: A + H(2)O + quinaldate = AH(2) + kynurenate." [EC:1.3.99.18, RHEA:16700] synonym: "quinaldic acid 4-oxidoreductase activity" EXACT [EC:1.3.99.18] synonym: "quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.18] xref: EC:1.3.99.18 xref: KEGG:R03687 xref: MetaCyc:1.3.99.18-RXN xref: RHEA:16700 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047123 name: quinoline-4-carboxylate 2-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: A + H(2)O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2)." [EC:1.3.99.19, RHEA:14952] synonym: "quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.19] synonym: "quinoline-4-carboxylic acid 2-oxidoreductase activity" EXACT [EC:1.3.99.19] xref: EC:1.3.99.19 xref: KEGG:R05183 xref: MetaCyc:1.3.99.19-RXN xref: RHEA:14952 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047124 name: L-erythro-3,5-diaminohexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H(2)O + NAD(+) = (S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH(4)(+)." [EC:1.4.1.11, RHEA:19636] synonym: "L-3,5-diaminohexanoate dehydrogenase activity" EXACT [EC:1.4.1.11] synonym: "L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.11] xref: EC:1.4.1.11 xref: KEGG:R03349 xref: MetaCyc:1.4.1.11-RXN xref: RHEA:19636 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0047125 name: delta1-piperideine-2-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate." [EC:1.5.1.21] synonym: "1,2-didehydropipecolate reductase activity" EXACT [EC:1.5.1.21] synonym: "1,2-didehydropipecolic reductase activity" EXACT [EC:1.5.1.21] synonym: "D1-piperideine-2-carboxylate reductase activity" EXACT [] synonym: "delta 1-piperideine-2-carboxylate reductase activity" EXACT [] synonym: "L-pipecolate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.5.1.21] synonym: "P2C reductase activity" EXACT [EC:1.5.1.21] xref: EC:1.5.1.21 xref: MetaCyc:RXN-8166 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047126 name: N5-(carboxyethyl)ornithine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H(2)O + NADP(+) = L-ornithine + H(+) + NADPH + pyruvate." [EC:1.5.1.24, RHEA:18664] subset: gosubset_prok synonym: "5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24] synonym: "N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24] xref: EC:1.5.1.24 xref: KEGG:R00666 xref: MetaCyc:1.5.1.24-RXN xref: RHEA:18664 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047127 name: thiomorpholine-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate." [EC:1.5.1.25, MetaCyc:1.5.1.25-RXN] synonym: "ketimine reductase activity" EXACT [EC:1.5.1.25] synonym: "ketimine-reducing enzyme" RELATED [EC:1.5.1.25] synonym: "thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity" EXACT [EC:1.5.1.25] xref: EC:1.5.1.25 xref: MetaCyc:1.5.1.25-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047128 name: 1,2-dehydroreticulinium reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH." [EC:1.5.1.27, RHEA:17572] synonym: "(R)-reticuline:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.27] synonym: "1,2-dehydroreticulinium ion reductase activity" EXACT [EC:1.5.1.27] xref: EC:1.5.1.27 xref: KEGG:R04695 xref: MetaCyc:1.5.1.27-RXN xref: RHEA:17572 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047129 name: opine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H(2)O + NAD(+) = L-2-aminopentanoate + H(+) + NADH + pyruvate." [EC:1.5.1.28, RHEA:21595] subset: gosubset_prok synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)" EXACT [EC:1.5.1.28] synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)" EXACT [EC:1.5.1.28] xref: EC:1.5.1.28 xref: KEGG:R03732 xref: MetaCyc:1.5.1.28-RXN xref: RHEA:21595 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047130 name: saccharopine dehydrogenase (NADP+, L-lysine-forming) activity namespace: molecular_function alt_id: GO:0010010 def: "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH." [EC:1.5.1.8, RHEA:19376] subset: gosubset_prok synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8] synonym: "L-lysine-alpha-ketoglutarate reductase activity" EXACT [EC:1.5.1.8] synonym: "lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)" EXACT [EC:1.5.1.8] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8] synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity" EXACT [EC:1.5.1.8] xref: EC:1.5.1.8 xref: KEGG:R00716 xref: MetaCyc:1.5.1.8-RXN xref: Reactome:82645 "saccharopine dehydrogenase (NADP+, L-lysine-forming) activity" xref: RHEA:19376 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0047131 name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH." [EC:1.5.1.9, RHEA:24523] synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9] synonym: "aminoadipic semialdehyde synthase activity" EXACT [EC:1.5.1.9] synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)" EXACT [EC:1.5.1.9] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9] synonym: "NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)" EXACT [EC:1.5.1.9] synonym: "saccharopin dehydrogenase activity" EXACT [EC:1.5.1.9] xref: EC:1.5.1.9 xref: KEGG:R02313 xref: MetaCyc:1.5.1.9-RXN xref: Reactome:82647 "saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity" xref: RHEA:24523 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0047132 name: dihydrobenzophenanthridine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine." [EC:1.5.3.12, MetaCyc:1.5.3.12-RXN] synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.12] xref: EC:1.5.3.12 xref: MetaCyc:1.5.3.12-RXN is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0047133 name: dimethylamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine." [EC:1.5.8.1, MetaCyc:1.5.8.1-RXN] subset: gosubset_prok synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activity" EXACT [EC:1.5.8.1] synonym: "DMADh activity" EXACT [EC:1.5.8.1] xref: EC:1.5.8.1 xref: MetaCyc:1.5.8.1-RXN xref: UM-BBD_reactionID:r1380 is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor [Term] id: GO:0047134 name: protein-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN] subset: gosubset_prok synonym: "disulfide reductase activity" EXACT [EC:1.8.1.8] synonym: "insulin-glutathione transhydrogenase activity" EXACT [EC:1.8.1.8] synonym: "NAD(P)H2:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8] synonym: "NAD(P)H:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8] synonym: "protein disulfide reductase activity" EXACT [EC:1.8.1.8] synonym: "protein disulphide reductase activity" EXACT [EC:1.8.1.8] synonym: "protein-disulfide reductase (NAD(P)H) activity" EXACT [] synonym: "protein-disulphide reductase activity" EXACT [] synonym: "protein-dithiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.8] xref: EC:1.8.1.8 xref: MetaCyc:1.6.4.4-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0047135 name: bis-gamma-glutamylcystine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH." [EC:1.8.1.13, RHEA:11983] synonym: "bis-g-glutamylcystine reductase (NADPH) activity" EXACT [] synonym: "Bis-gamma-glutamylcystine reductase (NADPH)" EXACT [EC:1.8.1.13] synonym: "bis-gamma-glutamylcystine reductase (NADPH) activity" EXACT [EC:1.8.1.13] synonym: "gamma-glutamylcysteine:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.13] synonym: "NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13] synonym: "NADPH:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13] xref: EC:1.8.1.13 xref: KEGG:R02742 xref: MetaCyc:1.6.4.9-RXN xref: RHEA:11983 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0047136 name: 4-(dimethylamino)phenylazoxybenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(dimethylamino)azobenzene + H(2)O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH." [EC:1.7.1.11, RHEA:19792] synonym: "4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.11] synonym: "dimethylaminoazobenzene N-oxide reductase activity" EXACT [EC:1.7.1.11] synonym: "N,N-dimethyl-p-aminoazobenzene oxide reductase activity" EXACT [EC:1.7.1.11] synonym: "NADPH-dependent DMAB N-oxide reductase activity" EXACT [EC:1.7.1.11] synonym: "NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11] synonym: "NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11] xref: EC:1.7.1.11 xref: KEGG:R04303 xref: MetaCyc:1.6.6.12-RXN xref: RHEA:19792 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0047137 name: N-hydroxy-2-acetamidofluorene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+." [EC:1.7.1.12, MetaCyc:1.7.1.12-RXN] synonym: "2-acetamidofluorene:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.12] synonym: "N-hydroxy-2-acetylaminofluorene reductase activity" EXACT [EC:1.7.1.12] synonym: "NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12] synonym: "NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12] xref: EC:1.7.1.12 xref: MetaCyc:1.7.1.12-RXN is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0047138 name: aquacobalamin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+." [EC:1.16.1.3, MetaCyc:1.6.99.12-RXN] subset: gosubset_prok synonym: "aquocobalamin reductase activity" EXACT [EC:1.16.1.3] synonym: "B(12a) reductase activity" EXACT [EC:1.16.1.3] synonym: "B12a reductase activity" EXACT [EC:1.16.1.3] synonym: "cob(II)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.3] synonym: "NADH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.3] synonym: "NADH2:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3] synonym: "NADH:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3] synonym: "vitamin B(12a) reductase activity" EXACT [EC:1.16.1.3] synonym: "vitamin B12a reductase activity" EXACT [EC:1.16.1.3] xref: EC:1.16.1.3 xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0047139 name: glutathione-homocystine transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine." [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN] synonym: "glutathione:homocystine oxidoreductase activity" EXACT [EC:1.8.4.1] xref: EC:1.8.4.1 xref: MetaCyc:1.8.4.1-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0047140 name: glutathione-CoA-glutathione transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione." [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN] synonym: "CoA:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3] synonym: "coenzyme A:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3] synonym: "coenzyme A:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.4.3] synonym: "glutathione coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3] synonym: "glutathione-coenzyme A glutathione disulfide transhydrogenase activity" EXACT [EC:1.8.4.3] synonym: "glutathione:coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3] xref: EC:1.8.4.3 xref: MetaCyc:1.8.4.3-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0047141 name: glutathione-cystine transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine." [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN] synonym: "glutathione:cystine oxidoreductase" EXACT [EC:1.8.4.4] synonym: "GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4] synonym: "NADPH-dependent GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4] xref: EC:1.8.4.4 xref: MetaCyc:1.8.4.4-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0047142 name: enzyme-thiol transhydrogenase (glutathione-disulfide) activity namespace: molecular_function def: "Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase." [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN] synonym: "[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "enzyme-thiol transhydrogenase (glutathione-disulphide) activity" EXACT [] synonym: "enzyme-thiol transhydrogenase (oxidized-glutathione) activity" EXACT [] synonym: "glutathione-dependent thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "thiol:disulphide oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7] xref: EC:1.8.4.7 xref: MetaCyc:1.8.4.7-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0047143 name: chlorate reductase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H(2)O + H(+)." [EC:1.97.1.1, RHEA:16352] subset: gosubset_prok synonym: "chlorate reductase C" RELATED [EC:1.97.1.1] synonym: "chlorite:acceptor oxidoreductase activity" EXACT [EC:1.97.1.1] xref: EC:1.97.1.1 xref: KEGG:R03575 xref: MetaCyc:1.97.1.1-RXN xref: RHEA:16352 xref: UM-BBD_reactionID:r0981 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0047144 name: 2-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [EC:2.3.1.52, MetaCyc:2-ACYL2.3.1.15-RXN] synonym: "2-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.52] synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.52] xref: EC:2.3.1.52 xref: MetaCyc:2-ACYL2.3.1.15-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047145 name: demethylsterigmatocystin 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.109, MetaCyc:2.1.1.109-RXN] synonym: "demethylsterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.109] synonym: "O-methyltransferase I" RELATED [EC:2.1.1.109] synonym: "S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity" EXACT [EC:2.1.1.109] xref: EC:2.1.1.109 xref: MetaCyc:2.1.1.109-RXN is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0047146 name: sterigmatocystin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.110, MetaCyc:2.1.1.110-RXN] synonym: "O-methyltransferase II activity" RELATED [EC:2.1.1.110] synonym: "S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity" EXACT [EC:2.1.1.110] synonym: "S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110] synonym: "sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110] synonym: "sterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.110] xref: EC:2.1.1.110 xref: MetaCyc:2.1.1.110-RXN is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0047147 name: trimethylsulfonium-tetrahydrofolate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)." [EC:2.1.1.19, RHEA:13696] synonym: "trimethylsulfonium-tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.19] synonym: "trimethylsulfonium:tetrahydrofolate N-methyltransferase activity" EXACT [EC:2.1.1.19] synonym: "trimethylsulphonium-tetrahydrofolate N-methyltransferase activity" EXACT [] xref: EC:2.1.1.19 xref: KEGG:R02573 xref: MetaCyc:2.1.1.19-RXN xref: RHEA:13696 is_a: GO:0008170 ! N-methyltransferase activity [Term] id: GO:0047148 name: methylamine-glutamate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH(4)(+)." [EC:2.1.1.21, RHEA:15840] synonym: "methylamine-glutamate methyltransferase activity" EXACT [EC:2.1.1.21] synonym: "methylamine:L-glutamate N-methyltransferase activity" EXACT [EC:2.1.1.21] synonym: "N-methylglutamate synthase activity" EXACT [EC:2.1.1.21] xref: EC:2.1.1.21 xref: KEGG:R01586 xref: MetaCyc:2.1.1.21-RXN xref: RHEA:15840 is_a: GO:0008170 ! N-methyltransferase activity [Term] id: GO:0047149 name: thetin-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H(+)." [EC:2.1.1.3, RHEA:22791] synonym: "dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.3] synonym: "dimethylthetin-homocysteine methyltransferase activity" EXACT [EC:2.1.1.3] synonym: "thetin-homocysteine methylpherase activity" EXACT [EC:2.1.1.3] xref: EC:2.1.1.3 xref: KEGG:R04153 xref: MetaCyc:2.1.1.3-RXN xref: RHEA:22791 is_a: GO:0008172 ! S-methyltransferase activity [Term] id: GO:0047150 name: betaine-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22339] synonym: "betaine-homocysteine methyltransferase activity" EXACT [EC:2.1.1.5] synonym: "betaine-homocysteine transmethylase activity" EXACT [EC:2.1.1.5] synonym: "trimethylammonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.5] xref: EC:2.1.1.5 xref: KEGG:R02821 xref: MetaCyc:2.1.1.5-RXN xref: RHEA:22339 is_a: GO:0008172 ! S-methyltransferase activity [Term] id: GO:0047151 name: methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+." [EC:2.1.1.74, MetaCyc:2.1.1.74-RXN] synonym: "5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.74] synonym: "5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity" EXACT [EC:2.1.1.74] synonym: "folate-dependent ribothymidyl synthase activity" EXACT [EC:2.1.1.74] synonym: "methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity" EXACT [EC:2.1.1.74] synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity" EXACT [] xref: EC:2.1.1.74 xref: KEGG:R03704 xref: MetaCyc:2.1.1.74-RXN is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0047152 name: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide." [EC:2.1.1.90, MetaCyc:2.1.1.90-RXN] comment: This function is the first step in the pathway of methanogenesis from methanol. subset: gosubset_prok synonym: "methanol cobalamin methyltransferase activity" EXACT [EC:2.1.1.90] synonym: "methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity" EXACT [EC:2.1.1.90] synonym: "methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity" EXACT [EC:2.1.1.90] synonym: "methanol:corrinoid methyltransferase activity" EXACT [] synonym: "methyltransferase 1" BROAD [] synonym: "MT 1" RELATED [EC:2.1.1.90] synonym: "MT1" RELATED [] synonym: "MtaB" RELATED [] xref: EC:2.1.1.90 xref: MetaCyc:2.1.1.90-RXN is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0047153 name: deoxycytidylate 5-hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate." [EC:2.1.2.8, RHEA:11283] synonym: "5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity" EXACT [EC:2.1.2.8] synonym: "d-cytidine 5'-monophosphate hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "dCMP hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "deoxyCMP hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "deoxycytidylate hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "deoxycytidylate hydroxymethyltransferase activity" EXACT [] synonym: "deoxycytidylic hydroxymethylase activity" EXACT [EC:2.1.2.8] xref: EC:2.1.2.8 xref: KEGG:R01669 xref: MetaCyc:2.1.2.8-RXN xref: RHEA:11283 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0047154 name: methylmalonyl-CoA carboxytransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA." [EC:2.1.3.1, MetaCyc:2.1.3.1-RXN] subset: gosubset_prok synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate" RELATED [EC:2.1.3.1] synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1] synonym: "(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1] synonym: "(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity" EXACT [EC:2.1.3.1] synonym: "methylmalonyl coenzyme A carboxyltransferase activity" EXACT [EC:2.1.3.1] synonym: "methylmalonyl-CoA carboxyltransferase activity" EXACT [] synonym: "methylmalonyl-CoA transcarboxylase activity" EXACT [EC:2.1.3.1] synonym: "oxalacetic transcarboxylase activity" EXACT [EC:2.1.3.1] synonym: "transcarboxylase activity" RELATED [EC:2.1.3.1] xref: EC:2.1.3.1 xref: MetaCyc:2.1.3.1-RXN xref: UM-BBD_reactionID:r0923 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0047155 name: 3-hydroxymethylcephem carbamoyltransferase activity namespace: molecular_function alt_id: GO:0045447 def: "Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem." [EC:2.1.3.7, MetaCyc:2.1.3.7-RXN] synonym: "3'-hydroxymethylcephem-O-carbamoyltransferase activity" EXACT [] synonym: "carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity" EXACT [EC:2.1.3.7] xref: EC:2.1.3.7 xref: MetaCyc:2.1.3.7-RXN is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0047156 name: acetoin-ribose-5-phosphate transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde." [EC:2.2.1.4, RHEA:21507] synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthase activity" EXACT [EC:2.2.1.4] synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthetase activity" EXACT [EC:2.2.1.4] synonym: "3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4] synonym: "3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4] xref: EC:2.2.1.4 xref: KEGG:R02345 xref: MetaCyc:2.2.1.4-RXN xref: RHEA:21507 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0047157 name: myelin-proteolipid O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA." [EC:2.3.1.100, MetaCyc:2.3.1.100-RXN] synonym: "[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100] synonym: "acyl-protein synthase activity" BROAD [EC:2.3.1.100] synonym: "myelin PLP acyltransferase activity" EXACT [EC:2.3.1.100] synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100] xref: EC:2.3.1.100 xref: MetaCyc:2.3.1.100-RXN is_a: GO:0016416 ! O-palmitoyltransferase activity [Term] id: GO:0047158 name: sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose." [EC:2.3.1.103, RHEA:22667] synonym: "1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103] synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity" EXACT [EC:2.3.1.103] synonym: "hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103] xref: EC:2.3.1.103 xref: KEGG:R00063 xref: MetaCyc:2.3.1.103-RXN xref: RHEA:22667 is_a: GO:0016753 ! O-sinapoyltransferase activity [Term] id: GO:0047159 name: 1-alkenylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA." [EC:2.3.1.104, MetaCyc:2.3.1.104-RXN] synonym: "acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.104] xref: EC:2.3.1.104 xref: MetaCyc:2.3.1.104-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047160 name: alkylglycerophosphate 2-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA." [EC:2.3.1.105, RHEA:18560] synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity" EXACT [EC:2.3.1.105] synonym: "alkyllyso-GP:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.105] xref: EC:2.3.1.105 xref: KEGG:R03455 xref: MetaCyc:2.3.1.105-RXN xref: RHEA:18560 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047161 name: tartronate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate." [EC:2.3.1.106, RHEA:10955] synonym: "hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.106] synonym: "sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.106] synonym: "tartronate sinapoyltransferase activity" EXACT [EC:2.3.1.106] xref: EC:2.3.1.106 xref: KEGG:R03965 xref: MetaCyc:2.3.1.106-RXN xref: RHEA:10955 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047162 name: 17-O-deacetylvindoline O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA." [EC:2.3.1.107, RHEA:24499] synonym: "17-O-deacetylvindoline-17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "DAT activity" EXACT [EC:2.3.1.107] synonym: "deacetylvindoline acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107] xref: EC:2.3.1.107 xref: KEGG:R03230 xref: MetaCyc:2.3.1.107-RXN xref: RHEA:24499 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047163 name: 3,4-dichloroaniline N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA." [EC:2.3.1.114, RHEA:21063] synonym: "malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity" EXACT [EC:2.3.1.114] xref: EC:2.3.1.114 xref: KEGG:R04050 xref: MetaCyc:2.3.1.114-RXN xref: RHEA:21063 is_a: GO:0050735 ! N-malonyltransferase activity [Term] id: GO:0047164 name: isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA." [EC:2.3.1.115, MetaCyc:2.3.1.115-RXN] synonym: "flavone (flavonol) 7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "MAT-7" RELATED [EC:2.3.1.115] xref: EC:2.3.1.115 xref: MetaCyc:2.3.1.115-RXN is_a: GO:0050736 ! O-malonyltransferase activity [Term] id: GO:0047165 name: flavonol-3-O-beta-glucoside O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA." [EC:2.3.1.116, MetaCyc:2.3.1.116-RXN] synonym: "flavonol 3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116] synonym: "malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.116] synonym: "malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116] synonym: "MAT-3" RELATED [EC:2.3.1.116] xref: EC:2.3.1.116 xref: MetaCyc:2.3.1.116-RXN is_a: GO:0050736 ! O-malonyltransferase activity [Term] id: GO:0047166 name: 1-alkenylglycerophosphoethanolamine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA." [EC:2.3.1.121, MetaCyc:2.3.1.121-RXN] synonym: "acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.121] xref: EC:2.3.1.121 xref: MetaCyc:2.3.1.121-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047167 name: 1-alkyl-2-acetylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA." [EC:2.3.1.125, MetaCyc:2.3.1.125-RXN] synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" EXACT [EC:2.3.1.125] synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.125] xref: EC:2.3.1.125 xref: MetaCyc:2.3.1.125-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047168 name: isocitrate O-dihydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA." [EC:2.3.1.126, RHEA:20759] synonym: "caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.126] xref: EC:2.3.1.126 xref: KEGG:R01946 xref: MetaCyc:2.3.1.126-RXN xref: RHEA:20759 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047169 name: galactarate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA." [EC:2.3.1.130, RHEA:13000] synonym: "feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.130] synonym: "galacturate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.130] xref: EC:2.3.1.130 xref: KEGG:R03727 xref: MetaCyc:2.3.1.130-RXN xref: RHEA:13000 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047170 name: glucarate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA." [EC:2.3.1.131, RHEA:23311] synonym: "sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.131] xref: EC:2.3.1.131 xref: KEGG:R02899 xref: MetaCyc:2.3.1.131-RXN xref: RHEA:23311 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047171 name: glucarolactone O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA." [EC:2.3.1.132, MetaCyc:2.3.1.132-RXN] synonym: "sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.132] xref: EC:2.3.1.132 xref: MetaCyc:2.3.1.132-RXN is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047172 name: shikimate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA." [EC:2.3.1.133, MetaCyc:2.3.1.133-RXN] synonym: "4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.133] synonym: "shikimate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.133] xref: EC:2.3.1.133 xref: MetaCyc:2.3.1.133-RXN is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047173 name: phosphatidylcholine-retinol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine." [EC:2.3.1.135, MetaCyc:2.3.1.135-RXN] synonym: "lecithin--retinol acyltransferase activity" EXACT [EC:2.3.1.135] synonym: "phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity" EXACT [EC:2.3.1.135] synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity" EXACT [EC:2.3.1.135] xref: EC:2.3.1.135 xref: MetaCyc:2.3.1.135-RXN xref: Reactome:82785 "phosphatidylcholine-retinol O-acyltransferase activity" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047174 name: putrescine N-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H(+)." [EC:2.3.1.138, RHEA:12439] synonym: "caffeoyl-CoA putrescine N-caffeoyl transferase activity" EXACT [EC:2.3.1.138] synonym: "caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.138] synonym: "hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138] synonym: "PHT" RELATED [EC:2.3.1.138] synonym: "putrescine hydroxycinnamoyl transferase activity" EXACT [EC:2.3.1.138] synonym: "putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138] xref: EC:2.3.1.138 xref: KEGG:R01944 xref: MetaCyc:2.3.1.138-RXN xref: RHEA:12439 is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0050734 ! hydroxycinnamoyltransferase activity [Term] id: GO:0047175 name: galactosylacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]." [EC:2.3.1.141, MetaCyc:2.3.1.141-RXN] synonym: "acyl-ACP:lyso-MGDG acyltransferase activity" EXACT [EC:2.3.1.141] synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.141] synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.141] xref: EC:2.3.1.141 xref: MetaCyc:2.3.1.141-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047176 name: beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.143, RHEA:19112] synonym: "1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] synonym: "beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity" EXACT [EC:2.3.1.143] synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] xref: EC:2.3.1.143 xref: KEGG:R04498 xref: MetaCyc:2.3.1.143-RXN xref: RHEA:19112 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047177 name: glycerophospholipid arachidonoyl-transferase (CoA-independent) activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.147, MetaCyc:2.3.1.147-RXN] synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147] synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147] xref: EC:2.3.1.147 xref: MetaCyc:2.3.1.147-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047178 name: glycerophospholipid acyltransferase (CoA-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.148, MetaCyc:2.3.1.148-RXN] synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" EXACT [EC:2.3.1.148] xref: EC:2.3.1.148 xref: MetaCyc:2.3.1.148-RXN is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0047179 name: platelet-activating factor acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid." [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN] synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity" EXACT [EC:2.3.1.149] synonym: "PAF acetyltransferase activity" EXACT [] xref: EC:2.3.1.149 xref: MetaCyc:2.3.1.149-RXN is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0047180 name: salutaridinol 7-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA." [EC:2.3.1.150, RHEA:22859] synonym: "acetyl-CoA:salutaridinol 7-O-acetyltransferase activity" EXACT [EC:2.3.1.150] xref: EC:2.3.1.150 xref: KEGG:R04723 xref: MetaCyc:2.3.1.150-RXN xref: RHEA:22859 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047181 name: benzophenone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A." [EC:2.3.1.151, MetaCyc:2.3.1.151-RXN] synonym: "malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.151] xref: EC:2.3.1.151 xref: MetaCyc:2.3.1.151-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047182 name: alcohol O-cinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate." [EC:2.3.1.152, MetaCyc:2.3.1.152-RXN] synonym: "1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity" EXACT [EC:2.3.1.152] xref: EC:2.3.1.152 xref: MetaCyc:2.3.1.152-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047183 name: anthocyanin 5-aromatic acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA." [EC:2.3.1.153, MetaCyc:2.3.1.153-RXN] synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.153] xref: EC:2.3.1.153 xref: MetaCyc:RXN-7945 is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0047184 name: 1-acylglycerophosphocholine O-acyltransferase activity namespace: molecular_function alt_id: GO:0000507 def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN] synonym: "1-acyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity" EXACT [EC:2.3.1.23] synonym: "acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "lysolecithin acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "lysophosphatide acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "lysophosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23] xref: EC:2.3.1.23 xref: MetaCyc:2.3.1.23-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047185 name: N-acetylneuraminate 4-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA." [EC:2.3.1.44, RHEA:18308] synonym: "acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity" EXACT [EC:2.3.1.44] synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.44] xref: EC:2.3.1.44 xref: KEGG:R01806 xref: MetaCyc:2.3.1.44-RXN xref: RHEA:18308 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047186 name: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA." [EC:2.3.1.45, MetaCyc:2.3.1.45-RXN] synonym: "acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "glycoprotein 7(9)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "N-acetylneuraminate 7(8)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "N-acetylneuraminate 7,8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45] xref: EC:2.3.1.45 xref: MetaCyc:2.3.1.45-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047187 name: deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate." [EC:2.3.1.49, MetaCyc:2.3.1.49-RXN] synonym: "deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity" EXACT [EC:2.3.1.49] synonym: "deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49] synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49] synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" EXACT [EC:2.3.1.49] xref: EC:2.3.1.49 xref: MetaCyc:2.3.1.49-RXN is_a: GO:0016418 ! S-acetyltransferase activity [Term] id: GO:0047188 name: aromatic-hydroxylamine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl." [EC:2.3.1.56, MetaCyc:2.3.1.56-RXN] synonym: "aromatic hydroxylamine acetyltransferase activity" EXACT [EC:2.3.1.56] synonym: "arylhydroxamate acyltransferase activity" EXACT [EC:2.3.1.56] synonym: "arylhydroxamic acid N,O-acetyltransferase activity" EXACT [EC:2.3.1.56] synonym: "arylhydroxamic acyltransferase activity" EXACT [EC:2.3.1.56] synonym: "N,O-acetyltransferase activity" EXACT [EC:2.3.1.56] synonym: "N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity" EXACT [EC:2.3.1.56] synonym: "N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity" EXACT [EC:2.3.1.56] xref: EC:2.3.1.56 xref: MetaCyc:2.3.1.56-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047189 name: 2,3-diaminopropionate N-oxalyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA." [EC:2.3.1.58, RHEA:13468] synonym: "ODAP synthase activity" EXACT [EC:2.3.1.58] synonym: "oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity" EXACT [EC:2.3.1.58] synonym: "oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity" EXACT [EC:2.3.1.58] synonym: "oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity" EXACT [EC:2.3.1.58] synonym: "oxalyldiaminopropionate synthase activity" EXACT [EC:2.3.1.58] synonym: "oxalyldiaminopropionic synthase activity" EXACT [EC:2.3.1.58] xref: EC:2.3.1.58 xref: KEGG:R04211 xref: MetaCyc:2.3.1.58-RXN xref: RHEA:13468 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047190 name: 2-acylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.62, RHEA:10335] synonym: "2-acylglycerol-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.62] synonym: "2-acylglycerophosphocholine acyltransferase activity" EXACT [EC:2.3.1.62] synonym: "acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.62] xref: EC:2.3.1.62 xref: KEGG:R01319 xref: MetaCyc:2.3.1.62-RXN xref: RHEA:10335 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047191 name: 1-alkylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN] synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.63] xref: EC:2.3.1.63 xref: MetaCyc:2.3.1.63-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047192 name: 1-alkylglycerophosphocholine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.67, MetaCyc:2.3.1.67-RXN] synonym: "1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "1-alkyl-2-lysolecithin acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acetyl-CoA:lyso-PAF acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.67] synonym: "blood platelet-activating factor acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lyso-GPC:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lyso-platelet activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lysoPAF:acetyl CoA acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "lysopaf:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67] synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67] xref: EC:2.3.1.67 xref: MetaCyc:2.3.1.67-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047193 name: CDP-acylglycerol O-arachidonoyltransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA." [EC:2.3.1.70, MetaCyc:2.3.1.70-RXN] comment: This term was made obsolete because the evidence for the existence of this reaction was retracted. Please see PMID:6885763 for more information. synonym: "arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase activity" EXACT [EC:2.3.1.70] synonym: "arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70] synonym: "CDP-acylglycerol O-arachidonyltransferase activity" EXACT [] synonym: "CDPacylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70] xref: EC:2.3.1.70 xref: MetaCyc:2.3.1.70-RXN is_obsolete: true [Term] id: GO:0047194 name: indoleacetylglucose-inositol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose." [EC:2.3.1.72, RHEA:21183] synonym: "1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity" EXACT [EC:2.3.1.72] synonym: "1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity" EXACT [EC:2.3.1.72] synonym: "indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity" EXACT [EC:2.3.1.72] xref: EC:2.3.1.72 xref: KEGG:R04333 xref: MetaCyc:2.3.1.72-RXN xref: RHEA:21183 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047195 name: diacylglycerol-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol." [EC:2.3.1.73, MetaCyc:2.3.1.73-RXN] synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" EXACT [EC:2.3.1.73] synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" EXACT [EC:2.3.1.73] xref: EC:2.3.1.73 xref: MetaCyc:2.3.1.73-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047196 name: long-chain-alcohol O-fatty-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA." [EC:2.3.1.75, MetaCyc:2.3.1.75-RXN] synonym: "acyl-CoA:long-chain-alcohol O-acyltransferase activity" EXACT [EC:2.3.1.75] synonym: "wax synthase activity" RELATED [EC:2.3.1.75] synonym: "wax-ester synthase activity" EXACT [EC:2.3.1.75] xref: EC:2.3.1.75 xref: MetaCyc:2.3.1.75-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047197 name: triglyceride-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol." [EC:2.3.1.77, MetaCyc:2.3.1.77-RXN] synonym: "triacylglycerol-sterol O-acyltransferase activity" EXACT [GOC:curators] synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" EXACT [EC:2.3.1.77] synonym: "triacylglycerol:sterol acyltransferase activity" EXACT [EC:2.3.1.77] xref: EC:2.3.1.77 xref: MetaCyc:2.3.1.77-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047198 name: cysteine-S-conjugate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H(+)." [EC:2.3.1.80, RHEA:19216] synonym: "acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity" EXACT [EC:2.3.1.80] xref: EC:2.3.1.80 xref: KEGG:R04950 xref: MetaCyc:2.3.1.80-RXN xref: RHEA:19216 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047199 name: phosphatidylcholine-dolichol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol." [EC:2.3.1.83, RHEA:19288] synonym: "3-sn-phosphatidylcholine:dolichol O-acyltransferase activity" EXACT [EC:2.3.1.83] xref: EC:2.3.1.83 xref: KEGG:R04227 xref: MetaCyc:2.3.1.83-RXN xref: RHEA:19288 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047200 name: tetrahydrodipicolinate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H(2)O = L-2-acetamido-6-oxopimelate + CoA." [EC:2.3.1.89, RHEA:13088] subset: gosubset_prok synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity" EXACT [EC:2.3.1.89] synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity" EXACT [EC:2.3.1.89] synonym: "acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity" EXACT [EC:2.3.1.89] synonym: "tetrahydrodipicolinate acetylase activity" EXACT [EC:2.3.1.89] synonym: "tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.89] xref: EC:2.3.1.89 xref: KEGG:R04364 xref: MetaCyc:2.3.1.89-RXN xref: RHEA:13088 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047201 name: beta-glucogallin O-galloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.90, RHEA:11419] synonym: "1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity" EXACT [EC:2.3.1.90] xref: EC:2.3.1.90 xref: KEGG:R00049 xref: MetaCyc:2.3.1.90-RXN xref: RHEA:11419 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047202 name: sinapoylglucose-choline O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose." [EC:2.3.1.91, RHEA:12027] synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity" EXACT [EC:2.3.1.91] synonym: "sinapine synthase activity" EXACT [EC:2.3.1.91] xref: EC:2.3.1.91 xref: KEGG:R03075 xref: MetaCyc:2.3.1.91-RXN xref: RHEA:12027 is_a: GO:0016753 ! O-sinapoyltransferase activity [Term] id: GO:0047203 name: 13-hydroxylupinine O-tigloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA." [EC:2.3.1.93, RHEA:12363] synonym: "(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity" EXACT [EC:2.3.1.93] synonym: "13-hydroxylupanine acyltransferase activity" EXACT [EC:2.3.1.93] synonym: "tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity" EXACT [EC:2.3.1.93] xref: EC:2.3.1.93 xref: KEGG:R04205 xref: MetaCyc:2.3.1.93-RXN xref: RHEA:12363 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047204 name: chlorogenate-glucarate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate." [EC:2.3.1.98, RHEA:23207] synonym: "chlorogenate:glucarate caffeoyltransferase activity" EXACT [EC:2.3.1.98] synonym: "chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.98] synonym: "chlorogenic acid:glucaric acid O-caffeoyltransferase activity" EXACT [EC:2.3.1.98] xref: EC:2.3.1.98 xref: KEGG:R02998 xref: MetaCyc:2.3.1.98-RXN xref: RHEA:23207 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047205 name: quinate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA." [EC:2.3.1.99, MetaCyc:2.3.1.99-RXN] synonym: "feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.99] synonym: "hydroxycinnamoyl coenzyme A-quinate transferase activity" EXACT [EC:2.3.1.99] xref: EC:2.3.1.99 xref: MetaCyc:2.3.1.99-RXN is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047206 name: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA." [EC:2.3.2.10, MetaCyc:2.3.2.10-RXN] synonym: "alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity" EXACT [EC:2.3.2.10] synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] xref: EC:2.3.2.10 xref: MetaCyc:2.3.2.10-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047207 name: 1,2-beta-fructan 1F-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (1,2-beta-D-fructosyl)(n) + (1,2-beta-D-fructosyl)(m) = (1,2-beta-D-fructosyl)(n+1) + (1,2-beta-D-fructosyl)(m-1)." [EC:2.4.1.100, MetaCyc:2.4.1.100-RXN] synonym: "1,2-beta-D-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-D-fructan 1F-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "2,1-fructan:2,1-fructan 1-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "FFT activity" EXACT [EC:2.4.1.100] synonym: "fructan:fructan fructosyl transferase activity" EXACT [EC:2.4.1.100] xref: EC:2.4.1.100 xref: MetaCyc:2.4.1.100-RXN is_a: GO:0050738 ! fructosyltransferase activity [Term] id: GO:0047208 name: o-dihydroxycoumarin 7-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H(+) + UDP." [EC:2.4.1.104, RHEA:14328] synonym: "UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104] synonym: "UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity" EXACT [EC:2.4.1.104] synonym: "UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104] synonym: "uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.104] xref: EC:2.4.1.104 xref: KEGG:R03548 xref: MetaCyc:2.4.1.104-RXN xref: RHEA:14328 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047209 name: coniferyl-alcohol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP." [EC:2.4.1.111, MetaCyc:2.4.1.111-RXN] synonym: "UDP-glucose coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111] synonym: "UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111] synonym: "UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111] synonym: "uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111] xref: EC:2.4.1.111 xref: MetaCyc:2.4.1.111-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047211 name: alpha-1,4-glucan-protein synthase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP." [EC:2.4.1.113, MetaCyc:2.4.1.113-RXN] synonym: "1,4alpha-glucan-protein synthase (ADP-forming) activity" EXACT [] synonym: "adenosine diphosphoglucose-protein glucosyltransferase activity" EXACT [EC:2.4.1.113] synonym: "ADP-glucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113] synonym: "ADPglucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113] synonym: "ADPglucose:protein glucosyltransferase activity" EXACT [EC:2.4.1.113] xref: EC:2.4.1.113 xref: MetaCyc:2.4.1.113-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047212 name: 2-coumarate O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H(+) + UDP." [EC:2.4.1.114, RHEA:10239] synonym: "UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114] synonym: "UDPG:o-coumaric acid O-glucosyltransferase activity" EXACT [EC:2.4.1.114] synonym: "UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114] synonym: "uridine diphosphoglucose-o-coumarate glucosyltransferase activity" EXACT [EC:2.4.1.114] xref: EC:2.4.1.114 xref: KEGG:R03710 xref: MetaCyc:2.4.1.114-RXN xref: RHEA:10239 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047213 name: anthocyanidin 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP." [EC:2.4.1.115, MetaCyc:2.4.1.115-RXN] synonym: "3-GT activity" EXACT [EC:2.4.1.115] synonym: "UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] xref: EC:2.4.1.115 xref: MetaCyc:2.4.1.115-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047214 name: cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP." [EC:2.4.1.116, MetaCyc:2.4.1.116-RXN] synonym: "cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116] synonym: "UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.116] synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.116] synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116] xref: EC:2.4.1.116 xref: MetaCyc:2.4.1.116-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047215 name: indole-3-acetate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP." [EC:2.4.1.121, RHEA:14924] synonym: "IAA-Glu synthetase activity" EXACT [EC:2.4.1.121] synonym: "IAA-glucose synthase activity" EXACT [EC:2.4.1.121] synonym: "IAGlu synthase activity" EXACT [EC:2.4.1.121] synonym: "indol-3-ylacetylglucose synthase activity" EXACT [EC:2.4.1.121] synonym: "UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121] synonym: "UDP-glucose:auxin glucosyltransferase activity" BROAD [] synonym: "UDP-glucose:indol-3-acetic acid glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:indol-3-ylacetate glucosyl-transferase activity" EXACT [EC:2.4.1.121] synonym: "UDP-glucose:indol-3-ylacetate glucosyltransferase activity" EXACT [EC:2.4.1.121] synonym: "UDPG-indol-3-ylacetyl glucosyl transferase activity" EXACT [EC:2.4.1.121] synonym: "UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121] synonym: "uridine diphosphoglucose-indoleacetate glucosyltransferase activity" EXACT [EC:2.4.1.121] xref: EC:2.4.1.121 xref: KEGG:R03094 xref: MetaCyc:2.4.1.121-RXN xref: RHEA:14924 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047216 name: inositol 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP." [EC:2.4.1.123, MetaCyc:2.4.1.123-RXN] synonym: "galactinol synthase activity" EXACT [EC:2.4.1.123] synonym: "inositol 1-alpha-galactosyltransferase activity" EXACT [] synonym: "UDP-D-galactose:inositol galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "uridine diphosphogalactose-inositol galactosyltransferase activity" EXACT [EC:2.4.1.123] xref: EC:2.4.1.123 xref: MetaCyc:2.4.1.123-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047217 name: sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose." [EC:2.4.1.125, MetaCyc:2.4.1.125-RXN] synonym: "GTF-S" RELATED [EC:2.4.1.125] synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase" BROAD [EC:2.4.1.125] synonym: "sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.125] synonym: "sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.125] synonym: "water-soluble-glucan synthase activity" RELATED [EC:2.4.1.125] xref: EC:2.4.1.125 xref: MetaCyc:2.4.1.125-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0047218 name: hydroxycinnamate 4-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP." [EC:2.4.1.126, MetaCyc:2.4.1.126-RXN] synonym: "hydroxycinnamoyl glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "UDP-glucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126] xref: EC:2.4.1.126 xref: MetaCyc:2.4.1.126-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047219 name: monoterpenol beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP." [EC:2.4.1.127, RHEA:11523] synonym: "UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127] synonym: "UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127] synonym: "UDPglucose:monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127] synonym: "uridine diphosphoglucose-monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127] xref: EC:2.4.1.127 xref: KEGG:R02179 xref: MetaCyc:2.4.1.127-RXN xref: RHEA:11523 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047220 name: galactosylxylosylprotein 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP." [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN] synonym: "galactosyltransferase II activity" RELATED [EC:2.4.1.134] synonym: "UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134] synonym: "UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134] synonym: "uridine diphosphogalactose-galactosylxylose galactosyltransferase activity" EXACT [EC:2.4.1.134] xref: EC:2.4.1.134 xref: MetaCyc:2.4.1.134-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047221 name: sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP." [EC:2.4.1.137, RHEA:14288] synonym: "floridoside phosphate synthase activity" EXACT [EC:2.4.1.137] synonym: "floridoside phosphate synthetase activity" EXACT [EC:2.4.1.137] synonym: "floridoside-phosphate synthase activity" EXACT [EC:2.4.1.137] synonym: "FPS" RELATED [EC:2.4.1.137] synonym: "UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity" EXACT [EC:2.4.1.137] synonym: "UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137] synonym: "UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity" EXACT [EC:2.4.1.137] synonym: "UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137] xref: EC:2.4.1.137 xref: KEGG:R00853 xref: MetaCyc:2.4.1.137-RXN xref: RHEA:14288 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047222 name: mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP." [EC:2.4.1.138, MetaCyc:2.4.1.138-RXN] synonym: "alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138] synonym: "UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.138] synonym: "uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138] xref: EC:2.4.1.138 xref: MetaCyc:2.4.1.138-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047223 name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN] synonym: "elongation 3-beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146] synonym: "elongation 3beta-GalNAc-transferase activity" EXACT [EC:2.4.1.146] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.146] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.146] synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)" EXACT [EC:2.4.1.146] xref: EC:2.4.1.146 xref: MetaCyc:2.4.1.146-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047224 name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.147, MetaCyc:2.4.1.147-RXN] synonym: "core 3-beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147] synonym: "core 3beta-GlcNAc-transferase activity" EXACT [EC:2.4.1.147] synonym: "mucin core 3 beta3-GlcNAc-transferase activity" EXACT [EC:2.4.1.147] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.147] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.147] synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.147] xref: EC:2.4.1.147 xref: MetaCyc:2.4.1.147-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047225 name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.148, MetaCyc:2.4.1.148-RXN] synonym: "core 4 beta6-GalNAc-transferase activity" EXACT [EC:2.4.1.148] synonym: "core 6-beta-GalNAc-transferase B activity" RELATED [EC:2.4.1.148] synonym: "core 6beta-GalNAc-transferase B" RELATED [EC:2.4.1.148] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.148] synonym: "UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.148] synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B" RELATED [EC:2.4.1.148] xref: EC:2.4.1.148 xref: MetaCyc:2.4.1.148-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047227 name: indolylacetyl-myo-inositol galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP." [EC:2.4.1.156, RHEA:21151] synonym: "indol-3-ylacetyl-myo-inositol galactoside synthase activity" EXACT [EC:2.4.1.156] synonym: "UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156] synonym: "UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156] synonym: "uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity" EXACT [EC:2.4.1.156] xref: EC:2.4.1.156 xref: KEGG:R04334 xref: MetaCyc:2.4.1.156-RXN xref: RHEA:21151 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047228 name: 1,2-diacylglycerol 3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP." [EC:2.4.1.157, MetaCyc:2.4.1.157-RXN] subset: gosubset_prok synonym: "UDP-glucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDP-glucose:1,2-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDPglucose:diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "uridine diphosphoglucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] xref: EC:2.4.1.157 xref: MetaCyc:2.4.1.157-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047229 name: 13-hydroxydocosanoate 13-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP." [EC:2.4.1.158, MetaCyc:2.4.1.158-RXN] synonym: "13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158] xref: EC:2.4.1.158 xref: MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047230 name: flavonol-3-O-glucoside L-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP." [EC:2.4.1.159, MetaCyc:2.4.1.159-RXN] synonym: "UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.159] synonym: "UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159] synonym: "uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159] xref: EC:2.4.1.159 xref: MetaCyc:2.4.1.159-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047231 name: pyridoxine 5'-O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP." [EC:2.4.1.160, RHEA:20180] synonym: "UDP-glucose-pyridoxine glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160] xref: EC:2.4.1.160 xref: KEGG:R01912 xref: MetaCyc:2.4.1.160-RXN xref: RHEA:20180 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047232 name: galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP." [EC:2.4.1.164, MetaCyc:2.4.1.164-RXN] synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.164] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.164] xref: EC:2.4.1.164 xref: MetaCyc:2.4.1.164-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047233 name: N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.165, MetaCyc:2.4.1.165-RXN] synonym: "UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165] synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165] xref: EC:2.4.1.165 xref: MetaCyc:2.4.1.165-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047234 name: raffinose-raffinose alpha-galactotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose." [EC:2.4.1.166, MetaCyc:2.4.1.166-RXN] subset: gosubset_prok synonym: "raffinose (raffinose donor) galactosyltransferase activity" EXACT [EC:2.4.1.166] synonym: "raffinose-raffinose a-galactosyltransferase activity" EXACT [] synonym: "raffinose-raffinose alpha-galactosyltransferase activity" EXACT [] synonym: "raffinose:raffinose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.166] synonym: "raffinose:raffinose alpha-galactosyltransferase activity" EXACT [EC:2.4.1.166] xref: EC:2.4.1.166 xref: MetaCyc:2.4.1.166-RXN is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0047235 name: sucrose 6F-alpha-galactotransferase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP." [EC:2.4.1.167, MetaCyc:2.4.1.167-RXN] synonym: "sucrose 6(F)-alpha-galactosyltransferase activity" EXACT [] synonym: "sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] xref: EC:2.4.1.167 xref: MetaCyc:2.4.1.167-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047236 name: methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP." [EC:2.4.1.171, MetaCyc:2.4.1.171-RXN] synonym: "cycasin synthase activity" EXACT [EC:2.4.1.171] synonym: "methyl-ONN-azoxymethanol glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.171] synonym: "UDPglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171] synonym: "uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171] xref: EC:2.4.1.171 xref: MetaCyc:2.4.1.171-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047237 name: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP." [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN] synonym: "glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "N-acetylgalactosaminyltransferase I activity" EXACT [] synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.174] synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I" RELATED [EC:2.4.1.174] synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" EXACT [EC:2.4.1.174] xref: EC:2.4.1.174 xref: MetaCyc:2.4.1.174-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047238 name: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN] synonym: "chondroitin synthase activity" EXACT [EC:2.4.1.175] synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "N-acetylgalactosaminyltransferase II activity" EXACT [] synonym: "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175] synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175] synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity" EXACT [EC:2.4.1.175] xref: EC:2.4.1.175 xref: MetaCyc:2.4.1.175-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047239 name: hydroxymandelonitrile glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H(+) + taxiphyllin + UDP." [EC:2.4.1.178, RHEA:15964] synonym: "cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.178] synonym: "UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178] synonym: "UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178] xref: EC:2.4.1.178 xref: KEGG:R02709 xref: MetaCyc:2.4.1.178-RXN xref: RHEA:15964 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047240 name: lactosylceramide beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H(+) + UDP." [EC:2.4.1.179, RHEA:18416] synonym: "UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179] synonym: "UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179] synonym: "uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity" EXACT [EC:2.4.1.179] xref: EC:2.4.1.179 xref: KEGG:R04431 xref: MetaCyc:2.4.1.179-RXN xref: RHEA:18416 is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity [Term] id: GO:0047241 name: lipopolysaccharide N-acetylmannosaminouronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP." [EC:2.4.1.180, MetaCyc:2.4.1.180-RXN] synonym: "LPS N-acetylmannosaminouronosyltransferase activity" EXACT [] synonym: "ManNAcA transferase activity" EXACT [EC:2.4.1.180] synonym: "UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity" EXACT [EC:2.4.1.180] synonym: "uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity" EXACT [EC:2.4.1.180] xref: EC:2.4.1.180 xref: MetaCyc:2.4.1.180-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047242 name: hydroxyanthraquinone glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP." [EC:2.4.1.181, MetaCyc:2.4.1.181-RXN] synonym: "anthraquinone-specific glucosyltransferase activity" EXACT [EC:2.4.1.181] synonym: "UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181] synonym: "UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181] synonym: "uridine diphosphoglucose-anthraquinone glucosyltransferase activity" EXACT [EC:2.4.1.181] xref: EC:2.4.1.181 xref: MetaCyc:2.4.1.181-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047243 name: flavanone 7-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP." [EC:2.4.1.185, MetaCyc:2.4.1.185-RXN] synonym: "hesperetin 7-O-glucosyl-transferase activity" EXACT [EC:2.4.1.185] synonym: "naringenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185] synonym: "UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185] synonym: "UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185] synonym: "uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185] xref: EC:2.4.1.185 xref: MetaCyc:2.4.1.185-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047244 name: N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.187, MetaCyc:2.4.1.187-RXN] subset: gosubset_prok synonym: "N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] synonym: "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] synonym: "UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] synonym: "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] xref: EC:2.4.1.187 xref: MetaCyc:TEICHOICSYN2-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047245 name: N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.188, MetaCyc:2.4.1.188-RXN] synonym: "UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188] synonym: "UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188] synonym: "UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188] synonym: "uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188] xref: EC:2.4.1.188 xref: MetaCyc:2.4.1.188-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047246 name: luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP." [EC:2.4.1.190, RHEA:14152] synonym: "LMT activity" RELATED [EC:2.4.1.190] synonym: "luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] synonym: "UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] synonym: "UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.190] xref: EC:2.4.1.190 xref: KEGG:R06827 xref: MetaCyc:2.4.1.190-RXN xref: RHEA:14152 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0047247 name: luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.191, RHEA:22119] synonym: "LDT" RELATED [EC:2.4.1.191] synonym: "UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] synonym: "UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] synonym: "UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity" EXACT [EC:2.4.1.191] synonym: "UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] synonym: "uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.191] xref: EC:2.4.1.191 xref: KEGG:R06828 xref: MetaCyc:2.4.1.191-RXN xref: RHEA:22119 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0047248 name: nuatigenin 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nuatigenin + UDP-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP." [EC:2.4.1.192, RHEA:19332] synonym: "nuatigenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.192] synonym: "UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192] synonym: "UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192] synonym: "uridine diphosphoglucose-nuatigenin glucosyltransferase activity" EXACT [EC:2.4.1.192] xref: EC:2.4.1.192 xref: KEGG:R04577 xref: MetaCyc:2.4.1.192-RXN xref: RHEA:19332 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047249 name: sarsapogenin 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP." [EC:2.4.1.193, RHEA:14464] synonym: "sarsapogenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.193] synonym: "UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193] synonym: "UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193] synonym: "uridine diphosphoglucose-sarsapogenin glucosyltransferase activity" EXACT [EC:2.4.1.193] xref: EC:2.4.1.193 xref: KEGG:R04359 xref: MetaCyc:2.4.1.193-RXN xref: RHEA:14464 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047250 name: 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP." [EC:2.4.1.194, RHEA:15156] synonym: "HBA glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "p-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "PHB glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "PHB-O-glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194] xref: EC:2.4.1.194 xref: KEGG:R01304 xref: MetaCyc:2.4.1.194-RXN xref: RHEA:15156 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047251 name: thiohydroximate beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP." [EC:2.4.1.195, MetaCyc:2.4.1.195-RXN] synonym: "desulfoglucosinolate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "N-hydroxythioamide S-beta-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "thiohydroximate S-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "UDPG:thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "uridine diphosphoglucose-thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] xref: EC:2.4.1.195 xref: MetaCyc:2.4.1.195-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047252 name: beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,6-alpha-D-mannosyloligodaccharide + beta-D-mannosylphosphodecaprenol = 1,6-alpha-D-mannosyl-1,6-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate." [EC:2.4.1.199, MetaCyc:2.4.1.199-RXN] synonym: "beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.199] synonym: "mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.199] xref: EC:2.4.1.199 xref: MetaCyc:2.4.1.199-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0047253 name: alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP." [EC:2.4.1.201, MetaCyc:2.4.1.201-RXN] synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity" EXACT [] synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.201] synonym: "N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201] synonym: "UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.201] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI" RELATED [EC:2.4.1.201] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201] xref: EC:2.4.1.201 xref: MetaCyc:2.4.1.201-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047254 name: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP." [EC:2.4.1.202, MetaCyc:2.4.1.202-RXN] synonym: "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202] synonym: "UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202] synonym: "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity" EXACT [EC:2.4.1.202] xref: EC:2.4.1.202 xref: MetaCyc:2.4.1.202-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047255 name: galactogen 6-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP." [EC:2.4.1.205, MetaCyc:2.4.1.205-RXN] synonym: "1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "beta-(1-6)-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "galactogen 6beta-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "uridine diphosphogalactose-galactogen galactosyltransferase activity" EXACT [EC:2.4.1.205] xref: EC:2.4.1.205 xref: MetaCyc:2.4.1.205-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047256 name: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.206, MetaCyc:2.4.1.206-RXN] synonym: "beta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] synonym: "LA2 synthase activity" EXACT [EC:2.4.1.206] synonym: "lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] synonym: "uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] xref: EC:2.4.1.206 xref: MetaCyc:2.4.1.206-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047257 name: diglucosyl diacylglycerol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol." [EC:2.4.1.208, MetaCyc:2.4.1.208-RXN] synonym: "DGlcDAG synthase activity" EXACT [EC:2.4.1.208] synonym: "diglucosyl diacylglycerol (DGlcDAG) synthase activity" EXACT [] synonym: "MGlcDAG (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] xref: EC:2.4.1.208 xref: MetaCyc:2.4.1.208-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047258 name: sphingosine beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine + UDP-D-galactose = H(+) + psychosine + UDP." [EC:2.4.1.23, RHEA:19488] synonym: "galactosyl-sphingosine transferase activity" EXACT [EC:2.4.1.23] synonym: "psychosine-UDP galactosyltransferase activity" EXACT [EC:2.4.1.23] synonym: "psychosine-uridine diphosphate galactosyltransferase activity" EXACT [EC:2.4.1.23] synonym: "UDP-galactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23] synonym: "UDPgalactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23] synonym: "UDPgalactose:sphingosine O-galactosyl transferase activity" EXACT [EC:2.4.1.23] synonym: "uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity" EXACT [EC:2.4.1.23] xref: EC:2.4.1.23 xref: KEGG:R01928 xref: MetaCyc:2.4.1.23-RXN xref: RHEA:19488 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047259 name: glucomannan 4-beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP." [EC:2.4.1.32, MetaCyc:2.4.1.32-RXN] synonym: "GDP-man-beta-mannan mannosyltransferase activity" EXACT [EC:2.4.1.32] synonym: "GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity" EXACT [] synonym: "glucomannan 4-b-mannosyltransferase activity" EXACT [] synonym: "glucomannan-synthase activity" EXACT [] xref: EC:2.4.1.32 xref: MetaCyc:2.4.1.32-RXN is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity [Term] id: GO:0047260 name: alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP." [EC:2.4.1.36, MetaCyc:2.4.1.36-RXN] synonym: "GDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "GDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "trehalose phosphate synthase (GDP-forming) activity" EXACT [EC:2.4.1.36] xref: EC:2.4.1.36 xref: MetaCyc:2.4.1.36-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047261 name: steroid N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H(+) + UDP." [EC:2.4.1.39, RHEA:14156] synonym: "hydroxy steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] synonym: "steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] synonym: "UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] synonym: "uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] xref: EC:2.4.1.39 xref: KEGG:R04451 xref: MetaCyc:2.4.1.39-RXN xref: RHEA:14156 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047262 name: polygalacturonate 4-alpha-galacturonosyltransferase activity namespace: molecular_function alt_id: GO:0050375 def: "Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP." [EC:2.4.1.43, MetaCyc:2.4.1.43-RXN] synonym: "UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] xref: EC:2.4.1.43 xref: MetaCyc:2.4.1.43-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047263 name: N-acylsphingosine galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP." [EC:2.4.1.47, MetaCyc:2.4.1.47-RXN] synonym: "UDP galactose-N-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47] synonym: "UDP-galactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47] synonym: "UDPgalactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47] synonym: "uridine diphosphogalactose-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47] xref: EC:2.4.1.47 xref: MetaCyc:2.4.1.47-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047264 name: heteroglycan alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reactions: heteroglycan + GDP-mannose = 1,2-alpha-D-mannosylheteroglycan + GDP, and heteroglycan + GDP-mannose = 1,3-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:2.4.1.48-RXN] synonym: "GDP mannose alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "heteropolysaccharide alpha-mannosyltransferase activity" EXACT [GOC:curators] xref: EC:2.4.1.48 xref: MetaCyc:2.4.1.48-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0047265 name: poly(glycerol-phosphate) alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP." [EC:2.4.1.52, MetaCyc:2.4.1.52-RXN] subset: gosubset_prok synonym: "UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52] synonym: "UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52] synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52] synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52] xref: EC:2.4.1.52 xref: MetaCyc:2.4.1.52-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047266 name: poly(ribitol-phosphate) beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP." [EC:2.4.1.53, MetaCyc:2.4.1.53-RXN] synonym: "UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53] synonym: "UDP-D-glucose polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53] synonym: "UDP-D-glucose:polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53] synonym: "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53] synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53] synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53] xref: EC:2.4.1.53 xref: MetaCyc:2.4.1.53-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047267 name: undecaprenyl-phosphate mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [EC:2.4.1.54, RHEA:12784] synonym: "GDP mannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54] synonym: "GDP-D-mannose:lipid phosphate transmannosylase activity" EXACT [EC:2.4.1.54] synonym: "GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity" EXACT [EC:2.4.1.54] synonym: "guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54] xref: EC:2.4.1.54 xref: KEGG:R07257 xref: MetaCyc:2.4.1.54-RXN xref: RHEA:12784 is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0047268 name: galactinol-raffinose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol." [EC:2.4.1.67, MetaCyc:2.4.1.67-RXN] synonym: "alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity" EXACT [EC:2.4.1.67] synonym: "stachyose synthetase activity" EXACT [EC:2.4.1.67] xref: EC:2.4.1.67 xref: MetaCyc:2.4.1.67-RXN is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0047269 name: poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP." [EC:2.4.1.70, MetaCyc:2.4.1.70-RXN] synonym: "UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70] synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.70] synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70] xref: EC:2.4.1.70 xref: MetaCyc:2.4.1.70-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047270 name: lipopolysaccharide glucosyltransferase II activity namespace: molecular_function def: "Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP." [EC:2.4.1.73, MetaCyc:2.4.1.73-RXN] synonym: "LPS glucosyltransferase II activity" EXACT [] synonym: "UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73] synonym: "UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73] synonym: "uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.73] xref: EC:2.4.1.73 xref: MetaCyc:2.4.1.73-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047271 name: glycosaminoglycan galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP." [EC:2.4.1.74, MetaCyc:2.4.1.74-RXN] synonym: "UDP-galactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74] synonym: "UDPgalactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74] synonym: "uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.74] xref: EC:2.4.1.74 xref: MetaCyc:2.4.1.74-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047272 name: phosphopolyprenol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP." [EC:2.4.1.78, MetaCyc:2.4.1.78-RXN] synonym: "UDP-glucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78] synonym: "UDPglucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78] synonym: "UDPglucose:polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78] synonym: "uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78] xref: EC:2.4.1.78 xref: MetaCyc:2.4.1.78-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047273 name: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity namespace: molecular_function alt_id: GO:0047226 def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide." [EC:2.4.1.79, MetaCyc:2.4.1.79-RXN] synonym: "beta-3GalNAc-T1 activity" EXACT [EC:2.4.1.79] synonym: "beta3GalNAc-T1" RELATED [EC:2.4.1.79] synonym: "galactosylgalactosylglucosylceramide beta-D- activity" EXACT [EC:2.4.1.79] synonym: "globoside synthase activity" EXACT [EC:2.4.1.79] synonym: "globoside synthetase activity" EXACT [EC:2.4.1.79] synonym: "globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] xref: EC:2.4.1.79 xref: MetaCyc:2.4.1.79-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047274 name: galactinol-sucrose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol." [EC:2.4.1.82, MetaCyc:2.4.1.82-RXN] synonym: "1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82] synonym: "alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82] synonym: "galactinol:sucrose 6-galactosyl transferase activity" EXACT [] synonym: "galactosyltransferase, galactinol-sucrose" EXACT [] synonym: "raffinose synthase activity" EXACT [] xref: EC:2.4.1.82 xref: MetaCyc:2.4.1.82-RXN is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0047275 name: glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.86, MetaCyc:2.4.1.86-RXN] synonym: "GalT-4" RELATED [EC:2.4.1.86] synonym: "paragloboside synthase activity" EXACT [EC:2.4.1.86] synonym: "UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86] synonym: "UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86] synonym: "uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.86] xref: EC:2.4.1.86 xref: MetaCyc:2.4.1.86-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047276 name: N-acetyllactosaminide 3-alpha-galactosyltransferase activity namespace: molecular_function alt_id: GO:0003946 def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP." [EC:2.4.1.87, MetaCyc:2.4.1.87-RXN] synonym: "alpha-galactosyltransferase activity" RELATED [EC:2.4.1.87] synonym: "beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [] synonym: "glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "N-acetyllactosaminide alpha-1,3-galactosyltransferase activity" EXACT [] synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87] xref: EC:2.4.1.87 xref: MetaCyc:2.4.1.151-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047277 name: globoside alpha-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.88, MetaCyc:2.4.1.88-RXN] synonym: "Forssman synthase activity" RELATED [EC:2.4.1.88] synonym: "forssman synthase activity" EXACT [EC:2.4.1.88] synonym: "globoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88] synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.88] synonym: "uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88] xref: EC:2.4.1.88 xref: MetaCyc:2.4.1.88-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047278 name: bilirubin-glucuronoside glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside." [EC:2.4.1.95, RHEA:16888] synonym: "bilirubin glucuronoside glucuronosyltransferase activity" EXACT [EC:2.4.1.95] synonym: "bilirubin monoglucuronide transglucuronidase activity" EXACT [EC:2.4.1.95] synonym: "bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity" EXACT [EC:2.4.1.95] xref: EC:2.4.1.95 xref: KEGG:R00062 xref: MetaCyc:2.4.1.95-RXN xref: RHEA:16888 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0047279 name: sn-glycerol-3-phosphate 1-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP." [EC:2.4.1.96, RHEA:20344] synonym: "glycerol 3-phosphate 1alpha-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "isofloridoside-phosphate synthase activity" EXACT [EC:2.4.1.96] synonym: "UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity" EXACT [EC:2.4.1.96] synonym: "UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity" EXACT [EC:2.4.1.96] xref: EC:2.4.1.96 xref: KEGG:R00854 xref: MetaCyc:2.4.1.96-RXN xref: RHEA:20344 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047280 name: nicotinamide phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide." [EC:2.4.2.12, RHEA:16152] synonym: "nicotinamide mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.12] synonym: "nicotinamide mononucleotide synthetase activity" EXACT [EC:2.4.2.12] synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.12] synonym: "NMN diphosphorylase activity" EXACT [EC:2.4.2.12] synonym: "NMN pyrophosphorylase activity" EXACT [EC:2.4.2.12] synonym: "NMN synthetase activity" EXACT [EC:2.4.2.12] xref: EC:2.4.2.12 xref: KEGG:R01271 xref: MetaCyc:2.4.2.12-RXN xref: Reactome:83046 "nicotinamide phosphoribosyltransferase activity" xref: RHEA:16152 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047281 name: dioxotetrahydropyrimidine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine." [EC:2.4.2.20, MetaCyc:2.4.2.20-RXN] synonym: "2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine phosphoribosyl transferase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20] xref: EC:2.4.2.20 xref: MetaCyc:2.4.2.20-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047282 name: dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H(+)." [EC:2.4.2.27, RHEA:24395] subset: gosubset_prok synonym: "dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] synonym: "dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] synonym: "thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] xref: EC:2.4.2.27 xref: KEGG:R04222 xref: MetaCyc:2.4.2.27-RXN xref: RHEA:24395 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047283 name: dolichyl-phosphate D-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP." [EC:2.4.2.32, MetaCyc:2.4.2.32-RXN] synonym: "UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity" EXACT [EC:2.4.2.32] xref: EC:2.4.2.32 xref: MetaCyc:2.4.2.32-RXN is_a: GO:0035252 ! UDP-xylosyltransferase activity [Term] id: GO:0047284 name: dolichyl-xylosyl-phosphate-protein xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein." [EC:2.4.2.33, MetaCyc:2.4.2.33-RXN] synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" EXACT [EC:2.4.2.33] xref: EC:2.4.2.33 xref: MetaCyc:2.4.2.33-RXN is_a: GO:0042285 ! xylosyltransferase activity [Term] id: GO:0047285 name: flavonol-3-O-glycoside xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP." [EC:2.4.2.35, MetaCyc:2.4.2.35-RXN] synonym: "UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.35] xref: EC:2.4.2.35 xref: MetaCyc:2.4.2.35-RXN is_a: GO:0035252 ! UDP-xylosyltransferase activity [Term] id: GO:0047286 name: NAD+-diphthamide ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide." [EC:2.4.2.36] subset: gosubset_prok synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.36] synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.36] synonym: "NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.36] synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.36 xref: MetaCyc:RXN-11372 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047287 name: lactosylceramide alpha-2,6-N-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP." [EC:2.4.99.11, MetaCyc:2.4.99.11-RXN] synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.11] synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.11] synonym: "CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11] synonym: "CMP-sialic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11] synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.11] xref: EC:2.4.99.11 xref: MetaCyc:2.4.99.11-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047288 name: monosialoganglioside sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP." [EC:2.4.99.2, MetaCyc:2.4.99.2-RXN] synonym: "CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.2] xref: EC:2.4.99.2 xref: MetaCyc:2.4.99.2-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047289 name: galactosyldiacylglycerol alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)." [EC:2.4.99.5, RHEA:11667] synonym: "CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.5] xref: EC:2.4.99.5 xref: KEGG:R03468 xref: MetaCyc:2.4.99.5-RXN xref: RHEA:11667 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047290 name: (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP." [EC:2.4.99.7, RHEA:10479] synonym: "(alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity" EXACT [] synonym: "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.7] synonym: "cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "neuac-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "sialyltransferase 3C activity" RELATED [EC:2.4.99.7] synonym: "sialyltransferase 7D activity" RELATED [EC:2.4.99.7] synonym: "SIAT7" RELATED [EC:2.4.99.7] synonym: "ST6GALNAC activity" EXACT [EC:2.4.99.7] xref: EC:2.4.99.7 xref: KEGG:R04635 xref: MetaCyc:2.4.99.7-RXN xref: RHEA:10479 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047291 name: lactosylceramide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3." [EC:2.4.99.9, MetaCyc:2.4.99.9-RXN] synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.9] synonym: "CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.9] synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.9] synonym: "CMP-sialic acid:lactosylceramide-sialyltransferase activity" EXACT [EC:2.4.99.9] synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity" EXACT [EC:2.4.99.9] synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.9] synonym: "ganglioside GM3 synthase activity" EXACT [EC:2.4.99.9] synonym: "ganglioside GM3 synthetase activity" EXACT [EC:2.4.99.9] synonym: "GM3 synthase activity" EXACT [EC:2.4.99.9] synonym: "GM3 synthetase activity" EXACT [EC:2.4.99.9] synonym: "SAT 1" RELATED [EC:2.4.99.9] xref: EC:2.4.99.9 xref: MetaCyc:2.4.99.9-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047292 name: trihydroxypterocarpan dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate." [EC:2.5.1.36, MetaCyc:2.5.1.36-RXN] synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36] synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity" EXACT [EC:2.5.1.36] synonym: "dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36] synonym: "dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity" EXACT [EC:2.5.1.36] xref: EC:2.5.1.36 xref: MetaCyc:2.5.1.36-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047293 name: 4-hydroxybenzoate nonaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate." [EC:2.5.1.39, MetaCyc:2.5.1.39-RXN] synonym: "4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39] synonym: "nonaprenyl-4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoate dimethylallyltransferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoate polyprenyltransferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoic acid-polyprenyl transferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoic-polyprenyl transferase activity" EXACT [EC:2.5.1.39] synonym: "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity" EXACT [EC:2.5.1.39] xref: EC:2.5.1.39 xref: MetaCyc:2.5.1.39-RXN is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0047294 name: phosphoglycerol geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.41, RHEA:23407] synonym: "geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41] synonym: "geranylgeranyl-transferase activity" EXACT [EC:2.5.1.41] synonym: "glycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41] xref: EC:2.5.1.41 xref: KEGG:R04158 xref: MetaCyc:2.5.1.41-RXN xref: RHEA:23407 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047295 name: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.42, RHEA:18112] synonym: "geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42] synonym: "geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42] synonym: "geranylgeranyltransferase II" RELATED [EC:2.5.1.42] xref: EC:2.5.1.42 xref: KEGG:R04520 xref: MetaCyc:2.5.1.42-RXN xref: RHEA:18112 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047296 name: homospermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2.5.1.44, MetaCyc:2.5.1.44-RXN] subset: gosubset_prok synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" EXACT [EC:2.5.1.44] xref: EC:2.5.1.44 xref: MetaCyc:2.5.1.44-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047297 name: asparagine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate." [EC:2.6.1.14, MetaCyc:2.6.1.14-RXN] synonym: "asparagine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14] synonym: "asparagine-keto acid aminotransferase activity" EXACT [EC:2.6.1.14] synonym: "asparagine-oxo-acid aminotransferase activity" EXACT [] synonym: "L-asparagine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14] xref: EC:2.6.1.14 xref: MetaCyc:2.6.1.14-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047298 name: (S)-3-amino-2-methylpropionate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate." [EC:2.6.1.22, RHEA:13996] subset: gosubset_prok synonym: "(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.22] synonym: "(S)-3-amino-2-methylpropionate aminotransferase activity" EXACT [] synonym: "beta-aminobutyric transaminase activity" EXACT [EC:2.6.1.22] synonym: "beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.22] synonym: "L-3-aminoisobutyrate aminotransferase activity" EXACT [EC:2.6.1.22] synonym: "L-3-aminoisobutyrate transaminase activity" EXACT [EC:2.6.1.22] synonym: "L-3-aminoisobutyric aminotransferase activity" EXACT [EC:2.6.1.22] synonym: "L-AIBAT activity" EXACT [EC:2.6.1.22] xref: EC:2.6.1.22 xref: KEGG:R04188 xref: MetaCyc:2.6.1.22-RXN xref: RHEA:13996 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047299 name: tryptophan-phenylpyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine." [EC:2.6.1.28, RHEA:13744] synonym: "L-tryptophan-alpha-ketoisocaproate aminotransferase activity" EXACT [EC:2.6.1.28] synonym: "L-tryptophan:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28] synonym: "tryptophan--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28] synonym: "tryptophan-phenylpyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.28 xref: KEGG:R01376 xref: MetaCyc:2.6.1.28-RXN xref: RHEA:13744 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047300 name: pyridoxamine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal." [EC:2.6.1.30, RHEA:12844] synonym: "pyridoxamine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.30] synonym: "pyridoxamine-pyruvate aminotransferase activity" EXACT [] synonym: "pyridoxamine-pyruvic transaminase" BROAD [EC:2.6.1.30] synonym: "pyridoxamine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.30] synonym: "pyridoxamineu-pyruvic transaminase activity" EXACT [EC:2.6.1.30] xref: EC:2.6.1.30 xref: KEGG:R01712 xref: MetaCyc:2.6.1.30-RXN xref: RHEA:12844 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047301 name: valine-3-methyl-2-oxovalerate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine." [EC:2.6.1.32, RHEA:11471] synonym: "L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine--3-methyl-2-oxovalerate aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine--isoleucine aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine--isoleucine transaminase activity" EXACT [EC:2.6.1.32] synonym: "valine-2-keto-methylvalerate aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine-3-methyl-2-oxovalerate aminotransferase activity" EXACT [] xref: EC:2.6.1.32 xref: KEGG:R02200 xref: MetaCyc:2.6.1.32-RXN xref: RHEA:11471 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047302 name: UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose." [EC:2.6.1.34, RHEA:18716] synonym: "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.34] synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [] synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity" EXACT [] synonym: "uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.34] xref: EC:2.6.1.34 xref: KEGG:R04529 xref: MetaCyc:2.6.1.34-RXN xref: RHEA:18716 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047303 name: glycine-oxaloacetate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate." [EC:2.6.1.35, RHEA:17144] synonym: "glycine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35] synonym: "glycine-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.35] synonym: "glycine-oxaloacetate aminotransferase activity" EXACT [] synonym: "glycine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35] xref: EC:2.6.1.35 xref: KEGG:R00373 xref: MetaCyc:2.6.1.35-RXN xref: RHEA:17144 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047304 name: 2-aminoethylphosphonate-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde." [EC:2.6.1.37, RHEA:17024] subset: gosubset_prok synonym: "(2-aminoethyl)phosphonate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonate transaminase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonic acid aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "2-aminoethylphosphonate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "2-aminoethylphosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "2-aminoethylphosphonate-pyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.37 xref: KEGG:R04152 xref: MetaCyc:2.6.1.37-RXN xref: RHEA:17024 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047305 name: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity namespace: molecular_function alt_id: GO:0047314 def: "Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine." [EC:2.6.1.40, RHEA:18396] comment: Note that this function was EC:2.6.1.61. synonym: "(R)-3-amino-2-methylpropanoate aminotransferase activity" EXACT [] synonym: "(R)-3-amino-2-methylpropanoate transaminase activity" EXACT [] synonym: "(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "(R)-3-amino-2-methylpropionate transaminase activity" EXACT [] synonym: "(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity" EXACT [] synonym: "beta-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40] synonym: "beta-aminoisobutyrate-pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "D-3-aminoisobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "D-3-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40] synonym: "D-3-aminoisobutyrate-pyruvate transaminase activity" EXACT [EC:2.6.1.40] synonym: "D-AIBAT activity" EXACT [EC:2.6.1.40] synonym: "D-beta-aminoisobutyrate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] xref: EC:2.6.1.40 xref: KEGG:R02050 xref: MetaCyc:2.6.1.40-RXN xref: Reactome:83109 "(R)-3-amino-2-methylpropionate-pyruvate transaminase activity" xref: RHEA:18396 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047306 name: D-methionine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine." [EC:2.6.1.41, RHEA:23839] synonym: "D-methionine aminotransferase activity" EXACT [EC:2.6.1.41] synonym: "D-methionine transaminase activity" EXACT [EC:2.6.1.41] synonym: "D-methionine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.41] synonym: "D-methionine-pyruvate aminotransferase activity" EXACT [] synonym: "D-methionine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.41] xref: EC:2.6.1.41 xref: KEGG:R03001 xref: MetaCyc:2.6.1.41-RXN xref: RHEA:23839 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047307 name: diaminobutyrate-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde." [EC:2.6.1.46, RHEA:12383] subset: gosubset_prok synonym: "diaminobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.46] synonym: "diaminobutyrate-pyruvate aminotransferase activity" EXACT [] synonym: "L-2,4-diaminobutanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.46] synonym: "L-diaminobutyric acid transaminase activity" EXACT [EC:2.6.1.46] xref: EC:2.6.1.46 xref: KEGG:R02293 xref: MetaCyc:2.6.1.46-RXN xref: RHEA:12383 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047308 name: alanine-oxomalonate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate." [EC:2.6.1.47, RHEA:18812] synonym: "alanine--oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47] synonym: "alanine-ketomalonate (mesoxalate) transaminase activity" EXACT [EC:2.6.1.47] synonym: "alanine-oxomalonate aminotransferase activity" EXACT [] synonym: "L-alanine-ketomalonate transaminase activity" EXACT [EC:2.6.1.47] synonym: "L-alanine:oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47] xref: EC:2.6.1.47 xref: KEGG:R02970 xref: MetaCyc:2.6.1.47-RXN xref: RHEA:18812 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047309 name: dihydroxyphenylalanine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.49, RHEA:15276] synonym: "3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.49] synonym: "aspartate-DOPP transaminase (ADT)" EXACT [EC:2.6.1.49] synonym: "dihydroxyphenylalanine aminotransferase activity" EXACT [] synonym: "dopa aminotransferase activity" EXACT [EC:2.6.1.49] synonym: "DOPA aminotransferase activity" EXACT [EC:2.6.1.49] synonym: "dopa transaminase activity" EXACT [EC:2.6.1.49] synonym: "glutamate-DOPP transaminase (GDT)" EXACT [EC:2.6.1.49] synonym: "L-dopa transaminase activity" EXACT [EC:2.6.1.49] synonym: "phenylalanine-DOPP transaminase (PDT)" EXACT [EC:2.6.1.49] xref: EC:2.6.1.49 xref: KEGG:R02077 xref: MetaCyc:2.6.1.49-RXN xref: RHEA:15276 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047310 name: glutamine-scyllo-inositol transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate." [EC:2.6.1.50, RHEA:22923] subset: gosubset_prok synonym: "glutamine scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50] synonym: "glutamine--scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50] synonym: "glutamine--scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50] synonym: "glutamine-scyllo-inosose aminotransferase activity" EXACT [] synonym: "glutamine-scyllo-inosose transaminase activity" EXACT [] synonym: "L-glutamine-keto-scyllo-inositol aminotransferase activity" EXACT [EC:2.6.1.50] synonym: "L-glutamine-scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50] synonym: "L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity" EXACT [EC:2.6.1.50] xref: EC:2.6.1.50 xref: KEGG:R02781 xref: MetaCyc:2.6.1.50-RXN xref: RHEA:22923 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047311 name: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine." [EC:2.6.1.56, RHEA:15500] synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity" EXACT [] synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity" EXACT [EC:2.6.1.56] synonym: "guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity" EXACT [EC:2.6.1.56] synonym: "L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity" EXACT [EC:2.6.1.56] xref: EC:2.6.1.56 xref: KEGG:R03502 xref: MetaCyc:2.6.1.56-RXN xref: RHEA:15500 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047312 name: L-phenylalanine:pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine." [EC:2.6.1.58, MetaCyc:2.6.1.58-RXN] synonym: "histidine aminotransferase activity" RELATED [GOC:kad] synonym: "histidine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.58, GOC:kad] synonym: "L-histidine:pyruvate aminotransferase activity" RELATED [GOC:kad] synonym: "L-phenylalanine(L-histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58] synonym: "L-phenylalanine:pyruvate transaminase activity" EXACT [GOC:kad] synonym: "phenylalanine (histidine) aminotransferase activity" BROAD [EC:2.6.1.58] synonym: "phenylalanine(histidine) aminotransferase activity" BROAD [] synonym: "phenylalanine(histidine) transaminase activity" BROAD [EC:2.6.1.58] synonym: "phenylalanine(histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58] xref: EC:2.6.1.58 xref: KEGG:R00692 xref: MetaCyc:2.6.1.58-RXN xref: Reactome:83137 "L-phenylalanine:pyruvate aminotransferase activity" is_a: GO:0070546 ! L-phenylalanine aminotransferase activity [Term] id: GO:0047313 name: aromatic-amino-acid-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid." [EC:2.6.1.60, MetaCyc:2.6.1.60-RXN] synonym: "aromatic-amino-acid--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60] synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60] xref: EC:2.6.1.60 xref: MetaCyc:2.6.1.60-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047315 name: kynurenine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine." [EC:2.6.1.63, RHEA:19252] synonym: "kynurenine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.63] synonym: "kynurenine-glyoxylate aminotransferase activity" EXACT [] synonym: "L-kynurenine:glyoxylate aminotransferase (cyclizing)" EXACT [EC:2.6.1.63] xref: EC:2.6.1.63 xref: KEGG:R01957 xref: MetaCyc:2.6.1.63-RXN xref: RHEA:19252 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047316 name: glutamine-phenylpyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine." [EC:2.6.1.64, RHEA:17596] synonym: "glutamine transaminase K activity" RELATED [EC:2.6.1.64] synonym: "glutamine--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64] synonym: "glutamine-phenylpyruvate aminotransferase activity" EXACT [] synonym: "L-glutamine:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64] xref: EC:2.6.1.64 xref: KEGG:R01375 xref: MetaCyc:2.6.1.64-RXN xref: RHEA:17596 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047317 name: N6-acetyl-beta-lysine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate." [EC:2.6.1.65, MetaCyc:2.6.1.65-RXN] synonym: "6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.65] synonym: "epsilon-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65] synonym: "N(6)-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65] synonym: "N6-acetyl-beta-lysine aminotransferase activity" EXACT [] xref: EC:2.6.1.65 xref: MetaCyc:2.6.1.65-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047319 name: aspartate-phenylpyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate." [EC:2.6.1.70, RHEA:14100] synonym: "aspartate--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70] synonym: "aspartate-phenylpyruvate aminotransferase activity" EXACT [] synonym: "L-aspartate:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70] xref: EC:2.6.1.70 xref: KEGG:R00695 xref: MetaCyc:2.6.1.70-RXN xref: RHEA:14100 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047320 name: D-4-hydroxyphenylglycine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate." [EC:2.6.1.72, RHEA:15592] synonym: "D-4-hydroxyphenylglycine aminotransferase activity" EXACT [] synonym: "D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.72] synonym: "D-hydroxyphenylglycine aminotransferase activity" EXACT [EC:2.6.1.72] xref: EC:2.6.1.72 xref: KEGG:R04234 xref: MetaCyc:2.6.1.72-RXN xref: RHEA:15592 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047321 name: diphosphate-protein phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein." [EC:2.7.99.1, MetaCyc:2.7.99.1-RXN] synonym: "diphosphate:microsomal-membrane-protein O-phosphotransferase activity" BROAD [EC:2.7.99.1] synonym: "DiPPT" RELATED [EC:2.7.99.1] synonym: "pyrophosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1] synonym: "pyrophosphate:protein phosphotransferase activity" EXACT [EC:2.7.99.1] synonym: "triphosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1] synonym: "triphosphate:microsomal-membrane-protein phosphotransferase activity" EXACT [EC:2.7.99.1] xref: EC:2.7.99.1 xref: MetaCyc:2.7.99.1-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047322 name: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP." [EC:2.7.11.31, MetaCyc:2.7.1.109-RXN] synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "3-hydroxy-3-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "AMPK" RELATED [EC:2.7.11.31] synonym: "ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity" EXACT [EC:2.7.11.31] synonym: "beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "HMG-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "reductase kinase activity" BROAD [EC:2.7.11.31] synonym: "STK29" RELATED [EC:2.7.11.31] xref: EC:2.7.11.31 xref: MetaCyc:2.7.1.109-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0047323 name: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.4] synonym: "3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity" EXACT [EC:2.7.11.4] synonym: "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity" EXACT [] synonym: "ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.4] synonym: "BCK" RELATED [EC:2.7.11.4] synonym: "BCKD kinase activity" EXACT [EC:2.7.11.4] synonym: "BCODH kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain 2-oxo acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain alpha-ketoacid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain keto acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.4] synonym: "STK2" RELATED [EC:2.7.11.4] xref: EC:2.7.11.4 xref: MetaCyc:2.7.11.4-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0047324 name: phosphoenolpyruvate-glycerone phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate." [EC:2.7.1.121, RHEA:18384] synonym: "phosphoenolpyruvate:glycerone phosphotransferase activity" EXACT [EC:2.7.1.121] xref: EC:2.7.1.121 xref: KEGG:R01012 xref: MetaCyc:2.7.1.121-RXN xref: RHEA:18384 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047325 name: inositol tetrakisphosphate 1-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN] synonym: "1D-myo-inositol-tetrakisphosphate 1-kinase activity" EXACT [EC:2.7.1.134] synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.134] synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.134] synonym: "ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.134] synonym: "inositol 3,4,5,6-tetrakisphosphate 1-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 1-kinase activity" EXACT [] synonym: "inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] synonym: "inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] xref: EC:2.7.1.134 xref: MetaCyc:2.7.1.134-RXN xref: Reactome:83183 "inositol tetrakisphosphate 1-kinase activity" is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0047326 name: inositol tetrakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN] synonym: "1D-myo-inositol-tetrakisphosphate 5-kinase activity" EXACT [] synonym: "ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.140] synonym: "inositol 1,3,4,6-tetrakisphosphate 5-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 5-kinase activity" EXACT [] xref: EC:2.7.1.140 xref: MetaCyc:2.7.1.140-RXN is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0047327 name: glycerol-3-phosphate-glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol." [EC:2.7.1.142, RHEA:21291] synonym: "sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.142] xref: EC:2.7.1.142 xref: KEGG:R00850 xref: MetaCyc:2.7.1.142-RXN xref: RHEA:21291 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047328 name: acyl-phosphate-hexose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid." [EC:2.7.1.61, MetaCyc:2.7.1.61-RXN] synonym: "acyl-phosphate:D-hexose phosphotransferase activity" EXACT [EC:2.7.1.61] synonym: "hexose phosphate:hexose phosphotransferase activity" EXACT [EC:2.7.1.61] xref: EC:2.7.1.61 xref: MetaCyc:2.7.1.61-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047329 name: phosphoramidate-hexose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3." [EC:2.7.1.62, MetaCyc:2.7.1.62-RXN] synonym: "phosphoramidate-hexose transphosphorylase activity" EXACT [EC:2.7.1.62] synonym: "phosphoramidate:hexose 1-phosphotransferase activity" EXACT [EC:2.7.1.62] synonym: "phosphoramidic-hexose transphosphorylase activity" EXACT [EC:2.7.1.62] xref: EC:2.7.1.62 xref: MetaCyc:2.7.1.62-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047330 name: polyphosphate-glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate." [EC:2.7.1.63, MetaCyc:2.7.1.63-RXN] subset: gosubset_prok synonym: "polyphosphate glucokinase activity" EXACT [EC:2.7.1.63] synonym: "polyphosphate-D-(+)-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.63] synonym: "polyphosphate-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63] synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63] xref: EC:2.7.1.63 xref: MetaCyc:2.7.1.63-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047331 name: diphosphate-glycerol phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + glycerol = glycerol 1-phosphate + H(+) + phosphate." [EC:2.7.1.79, RHEA:13692] synonym: "diphosphate:glycerol 1-phosphotransferase activity" EXACT [EC:2.7.1.79] synonym: "PPi-glycerol phosphotransferase activity" EXACT [EC:2.7.1.79] synonym: "pyrophosphate--glycerol phosphotransferase activity" EXACT [EC:2.7.1.79] xref: EC:2.7.1.79 xref: KEGG:R01044 xref: MetaCyc:2.7.1.79-RXN xref: RHEA:13692 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047332 name: diphosphate-serine phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H(+) + phosphate." [EC:2.7.1.80, RHEA:23767] synonym: "diphosphate:L-serine O-phosphotransferase activity" EXACT [EC:2.7.1.80] synonym: "pyrophosphate--serine phosphotransferase activity" EXACT [EC:2.7.1.80] synonym: "pyrophosphate-L-serine phosphotransferase activity" EXACT [EC:2.7.1.80] xref: EC:2.7.1.80 xref: KEGG:R00584 xref: MetaCyc:2.7.1.80-RXN xref: RHEA:23767 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047333 name: dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H(+)." [EC:2.7.1.88, RHEA:16284] synonym: "ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88] synonym: "ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88] synonym: "dihydrostreptomycin 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.88] synonym: "dihydrostreptomycin-6-phosphate 3'alpha-kinase activity" EXACT [EC:2.7.1.88] xref: EC:2.7.1.88 xref: KEGG:R03395 xref: MetaCyc:2.7.1.88-RXN xref: RHEA:16284 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0047334 name: diphosphate-fructose-6-phosphate 1-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate." [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN] subset: gosubset_prok synonym: "6-phosphofructokinase (diphosphate) activity" EXACT [EC:2.7.1.90] synonym: "6-phosphofructokinase (pyrophosphate) activity" EXACT [EC:2.7.1.90] synonym: "diphosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90] synonym: "diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90] synonym: "inorganic pyrophosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.90] synonym: "inorganic pyrophosphate-phosphofructokinase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate-dependent phosphofructo-1-kinase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate-fructose 6-phosphate phosphotransferase activity" EXACT [EC:2.7.1.90] xref: EC:2.7.1.90 xref: MetaCyc:2.7.1.90-RXN is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0047335 name: 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate." [EC:2.7.4.17, MetaCyc:2.7.4.17-RXN] synonym: "1,3-diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] xref: EC:2.7.4.17 xref: MetaCyc:2.7.4.17-RXN is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047336 name: 5-methyldeoxycytidine-5'-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H(+)." [EC:2.7.4.19, RHEA:11399] synonym: "ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity" EXACT [EC:2.7.4.19] xref: EC:2.7.4.19 xref: KEGG:R04235 xref: MetaCyc:2.7.4.19-RXN xref: RHEA:11399 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047337 name: dolichyl-diphosphate-polyphosphate phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate." [EC:2.7.4.20, MetaCyc:2.7.4.20-RXN] synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20] synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20] xref: EC:2.7.4.20 xref: MetaCyc:2.7.4.20-RXN is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047338 name: UTP:xylose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate." [EC:2.7.7.11, MetaCyc:2.7.7.11-RXN] synonym: "UDP-xylose pyrophosphorylase activity" EXACT [EC:2.7.7.11] synonym: "uridine diphosphoxylose pyrophosphorylase activity" EXACT [EC:2.7.7.11] synonym: "uridylyltransferase, xylose 1-phosphate" EXACT [EC:2.7.7.11] synonym: "UTP-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] synonym: "UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] synonym: "xylose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] synonym: "xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] xref: EC:2.7.7.11 xref: MetaCyc:2.7.7.11-RXN is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0047339 name: nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity namespace: molecular_function alt_id: GO:0047340 def: "Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate." [EC:2.7.7.28, MetaCyc:2.7.7.28-RXN] synonym: "GDP hexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] synonym: "GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity" NARROW [EC:2.7.7.28] synonym: "GTP:hexose-1-phosphate guanylyltransferase activity" NARROW [] synonym: "guanosine diphosphohexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] synonym: "hexose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.28] synonym: "hexose 1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] synonym: "hexose nucleotidylating enzyme activity" EXACT [EC:2.7.7.28] synonym: "hexose-1-phosphate guanylyltransferase activity" NARROW [] synonym: "NDP hexose pyrophosphorylase activity" EXACT [EC:2.7.7.28] synonym: "NDP-hexose diphosphorylase activity" EXACT [] synonym: "NDP-hexose pyrophosphorylase activity" EXACT [] synonym: "NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] synonym: "NTP:hexose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] synonym: "nucleoside diphosphohexose pyrophosphorylase activity" EXACT [EC:2.7.7.28] synonym: "nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] xref: EC:2.7.7.28 xref: MetaCyc:2.7.7.28-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0047341 name: fucose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose." [EC:2.7.7.30, RHEA:13552] synonym: "GDP fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GDP-fucose diphosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GDP-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GDP-L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GTP:beta-L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30] synonym: "GTP:fucose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "GTP:L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30] synonym: "guanosine diphosphate L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] xref: EC:2.7.7.30 xref: KEGG:R01951 xref: MetaCyc:2.7.7.30-RXN xref: RHEA:13552 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0047342 name: galactose-1-phosphate thymidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose." [EC:2.7.7.32, RHEA:17168] synonym: "dTDP galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] synonym: "dTDP-galactose diphosphorylase activity" EXACT [EC:2.7.7.32] synonym: "dTDP-galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] synonym: "dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32] synonym: "galactose 1-phosphate thymidylyl transferase activity" EXACT [EC:2.7.7.32] synonym: "thymidine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] synonym: "thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32] xref: EC:2.7.7.32 xref: KEGG:R02329 xref: MetaCyc:2.7.7.32-RXN xref: RHEA:17168 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0047343 name: glucose-1-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate." [EC:2.7.7.33, RHEA:18216] subset: gosubset_prok synonym: "CDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "CDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.33] synonym: "CDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33] synonym: "CTP:D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33] synonym: "CTP:glucose-1-phosphate cytidylyltransferase activity" EXACT [] synonym: "cytidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "cytidine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "cytidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] xref: EC:2.7.7.33 xref: KEGG:R00956 xref: MetaCyc:2.7.7.33-RXN xref: RHEA:18216 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0047344 name: glucose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose." [EC:2.7.7.34, RHEA:10711] synonym: "GDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] synonym: "GDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.34] synonym: "GDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] synonym: "GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.34] synonym: "GTP:glucose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] xref: EC:2.7.7.34 xref: KEGG:R00954 xref: MetaCyc:2.7.7.34-RXN xref: RHEA:10711 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0047345 name: ribose-5-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + ADP + H(+) = ADP-ribose + phosphate." [EC:2.7.7.35, RHEA:14532] synonym: "adenosine diphosphoribose phosphorylase activity" EXACT [EC:2.7.7.35] synonym: "ADP ribose phosphorylase activity" EXACT [EC:2.7.7.35] synonym: "ADP-ribose phosphorylase activity" EXACT [EC:2.7.7.35] synonym: "ADP:D-ribose-5-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.35] synonym: "ADP:ribose-5-phosphate adenylyltransferase activity" EXACT [] xref: EC:2.7.7.35 xref: KEGG:R01052 xref: MetaCyc:2.7.7.35-RXN xref: RHEA:14532 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0047346 name: aldose-1-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose." [EC:2.7.7.36, MetaCyc:2.7.7.36-RXN] synonym: "adenosine diphosphate glucose:orthophosphate adenylyltransferase activity" EXACT [EC:2.7.7.36] synonym: "adenosine diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "ADP sugar phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "ADP-aldose phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "ADP-sugar phosphorylase activity" BROAD [EC:2.7.7.36] synonym: "ADP:aldose-1-phosphate adenylyltransferase activity" EXACT [] synonym: "ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.36] synonym: "ADPaldose phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "sugar-1-phosphate adenylyltransferase activity" BROAD [EC:2.7.7.36] xref: EC:2.7.7.36 xref: MetaCyc:2.7.7.36-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0047347 name: aldose-1-phosphate nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose." [EC:2.7.7.37, MetaCyc:2.7.7.37-RXN] subset: gosubset_prok synonym: "glucose 1-phosphate inosityltransferase activity" EXACT [EC:2.7.7.37] synonym: "NDP sugar phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "NDP-aldose phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "NDP-sugar phosphorylase activity" BROAD [EC:2.7.7.37] synonym: "NDP:aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "NDPaldose phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "nucleoside diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "sugar nucleotide phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "sugar phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "sugar-1-phosphate nucleotidyltransferase activity" BROAD [EC:2.7.7.37] xref: EC:2.7.7.37 xref: MetaCyc:2.7.7.37-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0047348 name: glycerol-3-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate." [EC:2.7.7.39, RHEA:13364] subset: gosubset_prok synonym: "CDP-glycerol diphosphorylase activity" EXACT [EC:2.7.7.39] synonym: "CDP-glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] synonym: "CTP:glycerol 3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39] synonym: "CTP:glycerol-3-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:sn-glycerol-3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39] synonym: "cytidine diphosphate glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] synonym: "cytidine diphosphoglycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] synonym: "Gro-PCT" RELATED [EC:2.7.7.39] xref: EC:2.7.7.39 xref: KEGG:R00856 xref: MetaCyc:2.7.7.39-RXN xref: RHEA:13364 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0047349 name: D-ribitol-5-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate." [EC:2.7.7.40, RHEA:12459] subset: gosubset_prok synonym: "CDP ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "CDP-ribitol diphosphorylase activity" EXACT [EC:2.7.7.40] synonym: "CDP-ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "CTP:D-ribitol-5-phosphate cytidylyltransferase activity" EXACT [] synonym: "cytidine diphosphate ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "cytidine diphosphoribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "ribitol 5-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.40] xref: EC:2.7.7.40 xref: KEGG:R02921 xref: MetaCyc:2.7.7.40-RXN xref: RHEA:12459 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0047350 name: glucuronate-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate." [EC:2.7.7.44, RHEA:16328] synonym: "UDP-D-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "UDP-glucuronate pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "UDP-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "uridine diphosphoglucuronic pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity" EXACT [EC:2.7.7.44] synonym: "UTP:glucuronate-1-phosphate uridylyltransferase activity" EXACT [] xref: EC:2.7.7.44 xref: KEGG:R01381 xref: MetaCyc:2.7.7.44-RXN xref: RHEA:16328 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0047351 name: guanosine-triphosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 GTP = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H(+)." [EC:2.7.7.45, RHEA:18156] synonym: "GTP:GTP guanylyltransferase activity" BROAD [] xref: EC:2.7.7.45 xref: KEGG:R00012 xref: MetaCyc:2.7.7.45-RXN xref: RHEA:18156 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0047352 name: adenylylsulfate-ammonia adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-adenylyl sulfate + NH(4)(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate." [EC:2.7.7.51, RHEA:19200] synonym: "adenylylsulfate:ammonia adenylyltransferase activity" EXACT [EC:2.7.7.51] synonym: "adenylylsulphate-ammonia adenylyltransferase activity" EXACT [] synonym: "APSAT" RELATED [EC:2.7.7.51] xref: EC:2.7.7.51 xref: KEGG:R01619 xref: MetaCyc:2.7.7.51-RXN xref: RHEA:19200 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0047353 name: N-methylphosphoethanolamine cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate." [EC:2.7.7.57, RHEA:10579] synonym: "CTP:N-methylethanolamine-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57] synonym: "CTP:N-methylphosphoethanolamine cytidylyltransferase activity" EXACT [] synonym: "CTP:P-MEA cytidylyltransferase activity" EXACT [EC:2.7.7.57] synonym: "monomethylethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57] xref: EC:2.7.7.57 xref: KEGG:R03375 xref: MetaCyc:2.7.7.57-RXN xref: RHEA:10579 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0047354 name: sphingosine cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + sphingosine = CMP + H(+) + sphingosyl-phosphocholine." [EC:2.7.8.10, RHEA:21227] synonym: "CDP-choline-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] synonym: "CDP-choline:sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] synonym: "cytidine diphosphocholine-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] synonym: "phosphorylcholine-sphingosine transferase activity" EXACT [EC:2.7.8.10] synonym: "sphingosine choline phosphotransferase activity" EXACT [] xref: EC:2.7.8.10 xref: KEGG:R01929 xref: MetaCyc:2.7.8.10-RXN xref: RHEA:21227 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047355 name: CDP-glycerol glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP." [EC:2.7.8.12, MetaCyc:2.7.8.12-RXN] subset: gosubset_prok synonym: "CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity" EXACT [EC:2.7.8.12] synonym: "CDPglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12] synonym: "CGPTase activity" EXACT [EC:2.7.8.12] synonym: "cytidine diphosphoglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12] synonym: "glycerophosphate synthetase activity" EXACT [EC:2.7.8.12] synonym: "poly(glycerol phosphate) polymerase activity" EXACT [EC:2.7.8.12] synonym: "teichoic acid glycerol transferase activity" EXACT [EC:2.7.8.12] synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12] xref: EC:2.7.8.12 xref: MetaCyc:2.7.8.12-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047356 name: CDP-ribitol ribitolphosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP." [EC:2.7.8.14, MetaCyc:2.7.8.14-RXN] subset: gosubset_prok synonym: "CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity" EXACT [EC:2.7.8.14] synonym: "CDPribitol ribitolphosphotransferase activity" EXACT [EC:2.7.8.14] synonym: "poly(ribitol phosphate) synthetase activity" EXACT [EC:2.7.8.14] synonym: "polyribitol phosphate polymerase activity" EXACT [EC:2.7.8.14] synonym: "polyribitol phosphate synthetase activity" EXACT [EC:2.7.8.14] synonym: "teichoate synthase activity" EXACT [EC:2.7.8.14] synonym: "teichoate synthetase activity" EXACT [EC:2.7.8.14] synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14] xref: EC:2.7.8.14 xref: MetaCyc:2.7.8.14-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047357 name: UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H(+) + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP." [EC:2.7.8.18, RHEA:22443] synonym: "galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "galactosyl phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18] xref: EC:2.7.8.18 xref: KEGG:R00504 xref: MetaCyc:2.7.8.18-RXN xref: RHEA:22443 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047358 name: UDP-glucose-glycoprotein glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP." [EC:2.7.8.19, MetaCyc:2.7.8.19-RXN] synonym: "Glc-phosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "GlcPTase activity" EXACT [EC:2.7.8.19] synonym: "UDP-glucose:glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "UDPglucose-glycoprotein glucose phosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19] xref: EC:2.7.8.19 xref: MetaCyc:2.7.8.19-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047359 name: 1-alkenyl-2-acylglycerol choline phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP." [EC:2.7.8.22, MetaCyc:2.7.8.22-RXN] synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity" EXACT [EC:2.7.8.22] synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.22] xref: EC:2.7.8.22 xref: MetaCyc:2.7.8.22-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047360 name: undecaprenyl-phosphate galactose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP." [EC:2.7.8.6, RHEA:11655] subset: gosubset_prok synonym: "poly(isoprenol)-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "Poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "poly(isoprenyl)phosphate galactosephosphatetransferase activity" EXACT [EC:2.7.8.6] synonym: "UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "undecaprenyl phosphate galactosyl-1-phosphate transferase activity" EXACT [EC:2.7.8.6] xref: EC:2.7.8.6 xref: KEGG:R01535 xref: MetaCyc:2.7.8.6-RXN xref: RHEA:11655 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047361 name: phosphomannan mannosephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP." [EC:2.7.8.9, MetaCyc:2.7.8.9-RXN] synonym: "GDP-mannose:phosphomannan mannose phosphotransferase activity" EXACT [EC:2.7.8.9] xref: EC:2.7.8.9 xref: MetaCyc:2.7.8.9-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047362 name: thiosulfate-dithiol sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite." [EC:2.8.1.5, MetaCyc:2.8.1.5-RXN] synonym: "thiosulfate reductase activity" EXACT [EC:2.8.1.5] synonym: "thiosulfate:dithioerythritol sulfurtransferase activity" EXACT [EC:2.8.1.5] synonym: "thiosulphate-dithiol sulphurtransferase activity" EXACT [] synonym: "TSR" RELATED [EC:2.8.1.5] xref: EC:2.8.1.5 xref: MetaCyc:2.8.1.5-RXN is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0047363 name: triglucosylalkylacylglycerol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate." [EC:2.8.2.19, MetaCyc:2.8.2.19-RXN] synonym: "3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity" EXACT [EC:2.8.2.19] synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT [] synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" EXACT [EC:2.8.2.19] xref: EC:2.8.2.19 xref: MetaCyc:2.8.2.19-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047364 name: desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H(+)." [EC:2.8.2.24, RHEA:20284] synonym: "3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] synonym: "3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] synonym: "desulphoglucosinolate sulphotransferase activity" EXACT [] synonym: "PAPS-desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] xref: EC:2.8.2.24 xref: KEGG:R03214 xref: MetaCyc:2.8.2.24-RXN xref: RHEA:20284 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047365 name: quercetin-3-sulfate 3'-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,3'-disulfate." [EC:2.8.2.26, RHEA:22507] synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "flavonol 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "PAPS:flavonol 3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "quercetin-3-sulphate 3'-sulphotransferase activity" EXACT [] xref: EC:2.8.2.26 xref: KEGG:R02632 xref: MetaCyc:2.8.2.26-RXN xref: RHEA:22507 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047366 name: quercetin-3-sulfate 4'-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,4'-disulfate." [EC:2.8.2.27, RHEA:17208] synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] synonym: "flavonol 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] synonym: "PAPS:flavonol 3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] synonym: "quercetin-3-sulphate 4'-sulphotransferase activity" EXACT [] xref: EC:2.8.2.27 xref: KEGG:R02633 xref: MetaCyc:2.8.2.27-RXN xref: RHEA:17208 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047367 name: quercetin-3,3'-bissulfate 7-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.28, MetaCyc:2.8.2.28-RXN] synonym: "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "flavonol 7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "quercetin-3,3'-bissulphate 7-sulphotransferase activity" EXACT [] xref: EC:2.8.2.28 xref: MetaCyc:2.8.2.28-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047368 name: UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H(+) + UDP-N-acetyl-D-galactosamine 4,6-disulfate." [EC:2.8.2.7, RHEA:14340] synonym: "3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity" EXACT [EC:2.8.2.7] synonym: "UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity" EXACT [] synonym: "uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7] synonym: "uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7] xref: EC:2.8.2.7 xref: KEGG:R04476 xref: MetaCyc:2.8.2.7-RXN xref: RHEA:14340 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047369 name: succinate-hydroxymethylglutarate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate." [EC:2.8.3.13, MetaCyc:2.8.3.13-RXN] synonym: "dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity" EXACT [EC:2.8.3.13] synonym: "hydroxymethylglutarate coenzyme A-transferase activity" EXACT [EC:2.8.3.13] synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" EXACT [EC:2.8.3.13] xref: EC:2.8.3.13 xref: MetaCyc:2.8.3.13-RXN is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047370 name: succinate-citramalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate." [EC:2.8.3.7, MetaCyc:2.8.3.7-RXN] synonym: "citramalate coenzyme A-transferase activity" EXACT [EC:2.8.3.7] synonym: "itaconate CoA-transferase activity" EXACT [EC:2.8.3.7] synonym: "succinyl coenzyme A-citramalyl coenzyme A transferase activity" EXACT [EC:2.8.3.7] synonym: "succinyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.7] xref: EC:2.8.3.7 xref: MetaCyc:2.8.3.7-RXN is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047371 name: butyrate-acetoacetate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate." [EC:2.8.3.9, RHEA:12964] subset: gosubset_prok synonym: "butanoyl-CoA:acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9] synonym: "butyryl coenzyme A-acetoacetate coenzyme A-transferase activity" EXACT [EC:2.8.3.9] synonym: "butyryl-CoA-acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9] xref: EC:2.8.3.9 xref: KEGG:R01365 xref: MetaCyc:2.8.3.9-RXN xref: RHEA:12964 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047372 name: acylglycerol lipase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN] subset: gosubset_prok synonym: "fatty acyl monoester lipase activity" EXACT [EC:3.1.1.23] synonym: "glycerol-ester acylhydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerol hydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerol lipase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerolipase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceridase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceride hydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceride lipase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceridyllipase activity" EXACT [EC:3.1.1.23] xref: EC:3.1.1.23 xref: MetaCyc:3.1.1.23-RXN xref: Reactome:83299 "acylglycerol lipase activity" is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047373 name: acetoxybutynylbithiophene deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)." [EC:3.1.1.54, RHEA:11551] synonym: "5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity" EXACT [EC:3.1.1.54] synonym: "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity" EXACT [EC:3.1.1.54] synonym: "acetoxybutynylbithiophene esterase activity" EXACT [EC:3.1.1.54] xref: EC:3.1.1.54 xref: KEGG:R04490 xref: MetaCyc:3.1.1.54-RXN xref: RHEA:11551 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047374 name: methylumbelliferyl-acetate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate + H(+)." [EC:3.1.1.56, RHEA:12211] synonym: "4-methylumbelliferyl-acetate acylhydrolase activity" EXACT [EC:3.1.1.56] synonym: "esterase D activity" RELATED [EC:3.1.1.56] xref: EC:3.1.1.56 xref: KEGG:R04141 xref: MetaCyc:3.1.1.56-RXN xref: RHEA:12211 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047375 name: N-acetylgalactosaminoglycan deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan." [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN] synonym: "N-acetyl galactosaminoglycan deacetylase activity" EXACT [EC:3.1.1.58] synonym: "N-acetyl-D-galactosaminoglycan acetylhydrolase activity" EXACT [EC:3.1.1.58] synonym: "polysaccharide deacetylase activity" EXACT [EC:3.1.1.58] synonym: "Vi-polysaccharide deacetylase activity" EXACT [EC:3.1.1.58] xref: EC:3.1.1.58 xref: MetaCyc:3.1.1.58-RXN is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047376 name: all-trans-retinyl-palmitate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + retinol-palmitate = palmitate + retinol." [EC:3.1.1.64, MetaCyc:3.1.1.64-RXN] synonym: "all-trans-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.64] xref: EC:3.1.1.64 xref: MetaCyc:3.1.1.64-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047377 name: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)." [EC:3.1.1.66, RHEA:16316] synonym: "3,4-diacetoxybutinylbithiophene:4-acetate esterase activity" EXACT [EC:3.1.1.66] synonym: "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity" EXACT [EC:3.1.1.66] synonym: "diacetoxybutynylbithiophene acetate esterase activity" EXACT [EC:3.1.1.66] xref: EC:3.1.1.66 xref: KEGG:R04525 xref: MetaCyc:3.1.1.66-RXN xref: RHEA:16316 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047378 name: acetylalkylglycerol acetylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H(2)O = 1-alkyl-sn-glycerol + acetate + H(+)." [EC:3.1.1.71, RHEA:11555] synonym: "2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity" EXACT [EC:3.1.1.71] synonym: "alkylacetylglycerol acetylhydrolase activity" EXACT [EC:3.1.1.71] xref: EC:3.1.1.71 xref: KEGG:R04043 xref: MetaCyc:3.1.1.71-RXN xref: RHEA:11555 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047379 name: ADP-dependent short-chain-acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA." [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN] synonym: "ADP-dependent-short-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] synonym: "propionyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18] synonym: "propionyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] synonym: "propionyl-CoA thioesterase activity" EXACT [EC:3.1.2.18] synonym: "short-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18] synonym: "short-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] synonym: "short-chain acyl-CoA thioesterase activity" EXACT [EC:3.1.2.18] xref: EC:3.1.2.18 xref: MetaCyc:3.1.2.18-RXN is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047380 name: ADP-dependent medium-chain-acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA." [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN] subset: gosubset_prok synonym: "ADP-dependent-medium-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain hydrolase activity" EXACT [EC:3.1.2.19] synonym: "myristoyl-CoA thioesterase activity" EXACT [EC:3.1.2.19] xref: EC:3.1.2.19 xref: MetaCyc:3.1.2.19-RXN is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047381 name: dodecanoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function alt_id: GO:0016294 def: "Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]." [EC:3.1.2.21, MetaCyc:3.1.2.21-RXN] synonym: "dodecanoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "dodecanoyl-ACP hydrolase activity" EXACT [] synonym: "dodecanoyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21] synonym: "dodecyl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21] synonym: "dodecyl-acyl-carrier protein hydrolase" BROAD [EC:3.1.2.21] synonym: "lauroyl-[acyl-carrier-protein] hydrolase activity" EXACT [] synonym: "lauroyl-ACP hydrolase activity" EXACT [] synonym: "lauryl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21] synonym: "lauryl-acyl-carrier protein hydrolase activity" EXACT [EC:3.1.2.21] synonym: "lauryl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21] xref: EC:3.1.2.21 xref: MetaCyc:3.1.2.21-RXN is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0047382 name: methylphosphothioglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H(2)O = S-methyl-1-thio-D-glycerate + phosphate." [EC:3.1.3.14, RHEA:16084] synonym: "methylthiophosphoglycerate phosphatase activity" EXACT [EC:3.1.3.14] synonym: "S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity" EXACT [EC:3.1.3.14] xref: EC:3.1.3.14 xref: KEGG:R04317 xref: MetaCyc:3.1.3.14-RXN xref: RHEA:16084 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047383 name: guanidinodeoxy-scyllo-inositol-4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H(2)O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate." [EC:3.1.3.40, RHEA:15780] synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity" EXACT [EC:3.1.3.40] synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.40] synonym: "1-guanidino-scyllo-inositol 4-phosphatase activity" EXACT [EC:3.1.3.40] xref: EC:3.1.3.40 xref: KEGG:R03496 xref: MetaCyc:3.1.3.40-RXN xref: RHEA:15780 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047384 name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]." [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity" EXACT [EC:3.1.3.47] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.47] synonym: "reductase phosphatase activity" BROAD [EC:3.1.3.47] xref: EC:3.1.3.47 xref: MetaCyc:3.1.3.47-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047385 name: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]." [EC:3.1.3.52, MetaCyc:3.1.3.52-RXN] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.52] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.52] synonym: "branched-chain 2-keto acid dehydrogenase phosphatase activity" EXACT [EC:3.1.3.52] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" BROAD [EC:3.1.3.52] synonym: "branched-chain oxo-acid dehydrogenase phosphatase activity" RELATED [EC:3.1.3.52] xref: EC:3.1.3.52 xref: MetaCyc:3.1.3.52-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047386 name: fructose-2,6-bisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H(2)O = beta-D-fructofuranose 2-phosphate + phosphate." [EC:3.1.3.54, RHEA:13336] synonym: "beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] synonym: "D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] synonym: "fructose 2,6-bisphosphate-6-phosphohydrolase activity" EXACT [EC:3.1.3.54] synonym: "fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] xref: EC:3.1.3.54 xref: KEGG:R02730 xref: MetaCyc:3.1.3.54-RXN xref: RHEA:13336 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047387 name: serine-ethanolaminephosphate phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + serine phosphoethanolamine = H(+) + phosphoethanolamine + serine." [EC:3.1.4.13, RHEA:17116] subset: gosubset_prok synonym: "SEP diesterase activity" EXACT [EC:3.1.4.13] synonym: "serine ethanolamine phosphodiester phosphodiesterase activity" EXACT [EC:3.1.4.13] synonym: "serine-phosphoethanolamine ethanolaminephosphohydrolase activity" EXACT [EC:3.1.4.13] xref: EC:3.1.4.13 xref: KEGG:R02817 xref: MetaCyc:3.1.4.13-RXN xref: RHEA:17116 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047388 name: adenylyl-[glutamate-ammonia ligase] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)]." [EC:3.1.4.15, MetaCyc:3.1.4.15-RXN] synonym: "adenylyl(glutamine synthetase) hydrolase activity" EXACT [EC:3.1.4.15] synonym: "adenylyl-glutamate-ammonia ligase hydrolase activity" EXACT [EC:3.1.4.15] synonym: "adenylyl-glutamine-synthetasehydrolase activity" EXACT [EC:3.1.4.15] synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity" EXACT [EC:3.1.4.15] xref: EC:3.1.4.15 xref: KEGG:R03474 xref: MetaCyc:3.1.4.15-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047389 name: glycerophosphocholine phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN] subset: gosubset_prok synonym: "glycerolphosphorylcholine phosphodiesterase activity" EXACT [EC:3.1.4.2] synonym: "glycerophosphinicocholine diesterase activity" EXACT [EC:3.1.4.2] synonym: "glycerophosphohydrolase activity" EXACT [EC:3.1.4.2] synonym: "glycerylphosphorylcholinediesterase activity" EXACT [EC:3.1.4.2] synonym: "sn-glycero-3-phosphocholine glycerophosphohydrolase activity" EXACT [EC:3.1.4.2] synonym: "sn-glycero-3-phosphorylcholine diesterase activity" EXACT [EC:3.1.4.2] xref: EC:3.1.4.2 xref: MetaCyc:3.1.4.2-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047390 name: glycerophosphocholine cholinephosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+)." [EC:3.1.4.38, RHEA:19548] synonym: "L-3-glycerylphosphinicocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38] synonym: "sn-glycero-3-phosphocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38] xref: EC:3.1.4.38 xref: KEGG:R02591 xref: MetaCyc:3.1.4.38-RXN xref: RHEA:19548 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047391 name: alkylglycerophosphoethanolamine phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate." [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN] synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity" EXACT [EC:3.1.4.39] synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39] xref: EC:3.1.4.39 xref: MetaCyc:3.1.4.39-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047392 name: CMP-N-acylneuraminate phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP." [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN] synonym: "CMP-N-acetylneuraminate hydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-N-acylneuraminate N-acylneuraminohydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-N-acylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-sialate hydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-sialic acid hydrolase activity" EXACT [EC:3.1.4.40] synonym: "cytidine monophosphate-N-acetylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40] synonym: "cytidine monophosphosialate hydrolase activity" EXACT [EC:3.1.4.40] synonym: "cytidine monophosphosialic hydrolase activity" EXACT [EC:3.1.4.40] xref: EC:3.1.4.40 xref: MetaCyc:3.1.4.40-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047393 name: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H(2)O = glycerol 1-phosphate + H(+)." [EC:3.1.4.42, RHEA:16496] synonym: "rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity" EXACT [EC:3.1.4.42] synonym: "rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity" EXACT [EC:3.1.4.42] xref: EC:3.1.4.42 xref: KEGG:R02648 xref: MetaCyc:3.1.4.42-RXN xref: RHEA:16496 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047394 name: glycerophosphoinositol inositolphosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol." [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN] subset: gosubset_prok synonym: "1,2-cyclic-inositol-phosphate phosphodiesterase activity" EXACT [] synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] xref: EC:3.1.4.43 xref: MetaCyc:3.1.4.43-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047395 name: glycerophosphoinositol glycerophosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+)." [EC:3.1.4.44, RHEA:16504] synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] synonym: "sn-glycero(3)phosphoinositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] synonym: "sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] xref: EC:3.1.4.44 xref: KEGG:R01193 xref: MetaCyc:3.1.4.44-RXN xref: RHEA:16504 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047396 name: glycosylphosphatidylinositol diacylglycerol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN] subset: gosubset_prok synonym: "(glycosyl)phosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14] synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]" RELATED [EC:4.6.1.14] synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity" EXACT [EC:4.6.1.14] synonym: "glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity" EXACT [EC:4.6.1.14] synonym: "glycosylphosphatidylinositol-phospholipase C activity" NARROW [EC:4.6.1.14] synonym: "glycosylphosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14] synonym: "GPI-PLC activity" EXACT [EC:4.6.1.14] synonym: "GPI-specific phospholipase C activity" EXACT [EC:4.6.1.14] synonym: "variant-surface-glycoprotein phospholipase C activity" EXACT [] synonym: "VSG-lipase activity" EXACT [EC:4.6.1.14] xref: EC:4.6.1.14 xref: MetaCyc:3.1.4.47-RXN is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0047397 name: dolichylphosphate-glucose phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose." [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN] synonym: "Dol-P-Glc phosphodiesterase activity" EXACT [EC:3.1.4.48] synonym: "dolichol phosphoglucose phosphodiesterase activity" EXACT [EC:3.1.4.48] synonym: "dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.48] synonym: "dolichyl-phosphate-glucose phosphodiesterase activity" EXACT [] xref: EC:3.1.4.48 xref: MetaCyc:3.1.4.48-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047398 name: dolichylphosphate-mannose phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose." [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN] synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.49] synonym: "mannosylphosphodolichol phosphodiesterase activity" EXACT [EC:3.1.4.49] xref: EC:3.1.4.49 xref: MetaCyc:3.1.4.49-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047399 name: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate." [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN] synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity" EXACT [EC:3.1.4.51] synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.51] xref: EC:3.1.4.51 xref: MetaCyc:3.1.4.51-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047400 name: phosphonoacetate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phosphonoacetate = acetate + H(+) + phosphate." [EC:3.11.1.2, RHEA:16752] synonym: "phosphonoacetate phosphonohydrolase activity" EXACT [EC:3.11.1.2] xref: EC:3.11.1.2 xref: KEGG:R00318 xref: MetaCyc:3.11.1.2-RXN xref: RHEA:16752 is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds [Term] id: GO:0047401 name: trithionate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + trithionate = H(+) + sulfate + thiosulfate." [EC:3.12.1.1, RHEA:21887] synonym: "trithionate thiosulfohydrolase activity" EXACT [EC:3.12.1.1] xref: EC:3.12.1.1 xref: KEGG:R01930 xref: MetaCyc:3.12.1.1-RXN xref: RHEA:21887 is_a: GO:0016828 ! hydrolase activity, acting on acid sulfur-sulfur bonds [Term] id: GO:0047402 name: protein-glucosylgalactosylhydroxylysine glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose." [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN] synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity" EXACT [EC:3.2.1.107] synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" EXACT [EC:3.2.1.107] xref: EC:3.2.1.107 xref: MetaCyc:3.2.1.107-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0047403 name: lacto-N-biosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc." [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN] synonym: "oligosaccharide lacto-N-biosylhydrolase activity" RELATED [EC:3.2.1.140] xref: EC:3.2.1.140 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047404 name: glucuronosyl-disulfoglucosamine glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine." [EC:3.2.1.56, MetaCyc:3.2.1.56-RXN] synonym: "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56] synonym: "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56] synonym: "glucuronosyl-disulphoglucosamine glucuronidase activity" EXACT [] xref: EC:3.2.1.56 xref: MetaCyc:3.2.1.56-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047405 name: pyrimidine-5'-nucleotide nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine." [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN] synonym: "Pyr5N activity" EXACT [EC:3.2.2.10] synonym: "pyrimidine nucleotide N-ribosidase activity" EXACT [EC:3.2.2.10] synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" EXACT [EC:3.2.2.10] xref: EC:3.2.2.10 xref: MetaCyc:3.2.2.10-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047406 name: beta-aspartyl-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-D-glucosamine + L-asparagine." [EC:3.2.2.11, RHEA:12327] synonym: "1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity" EXACT [EC:3.2.2.11] synonym: "beta-aspartylacetylglucosaminidase activity" EXACT [EC:3.2.2.11] xref: EC:3.2.2.11 xref: KEGG:R01266 xref: MetaCyc:3.2.2.11-RXN xref: RHEA:12327 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047407 name: ADP-ribosyl-[dinitrogen reductase] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]." [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN] subset: gosubset_prok synonym: "ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.24] synonym: "ADP-ribosyl glycohydrolase activity" EXACT [EC:3.2.2.24] synonym: "ADP-ribosyl-dinitrogen reductase hydrolase activity" EXACT [EC:3.2.2.24] synonym: "azoferredoxin glycosidase activity" EXACT [EC:3.2.2.24] synonym: "azoferredoxin-activating enzymes" RELATED [EC:3.2.2.24] synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [EC:3.2.2.24] synonym: "dinitrogenase reductase-activating glycohydrolase activity" EXACT [EC:3.2.2.24] xref: EC:3.2.2.24 xref: MetaCyc:3.2.2.24-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047408 name: alkenylglycerophosphocholine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde." [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN] synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity" EXACT [EC:3.3.2.2] synonym: "lysoplasmalogenase activity" EXACT [EC:3.3.2.2] xref: EC:3.3.2.2 xref: MetaCyc:3.3.2.2-RXN is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0047409 name: alkenylglycerophosphoethanolamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde." [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN] synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" EXACT [EC:3.3.2.5] xref: EC:3.3.2.5 xref: MetaCyc:3.3.2.5-RXN is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0047410 name: N-formylmethionylaminoacyl-tRNA deformylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate." [EC:3.5.1.27, MetaCyc:3.5.1.27-RXN] synonym: "N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity" EXACT [EC:3.5.1.27] xref: EC:3.5.1.27 xref: MetaCyc:3.5.1.27-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047411 name: 2-(acetamidomethylene)succinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate." [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN] synonym: "2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.29] synonym: "alpha-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.29] xref: EC:3.5.1.29 xref: MetaCyc:3.5.1.29-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047412 name: N-(long-chain-acyl)ethanolamine deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid." [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN] synonym: "acylethanolamine amidase activity" EXACT [] synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT [] synonym: "N-acylethanolamine amidohydrolase activity" EXACT [] xref: EC:3.5.1.60 xref: MetaCyc:3.5.1.60-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047413 name: N(alpha)-benzyloxycarbonylleucine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H(2)O + H(+) = L-leucine + benzyl alcohol + CO(2)." [EC:3.5.1.64, RHEA:18904] synonym: "alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64] synonym: "benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64] synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV" RELATED [EC:3.5.1.64] synonym: "nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64] synonym: "nalpha-benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64] xref: EC:3.5.1.64 xref: KEGG:R02552 xref: MetaCyc:3.5.1.64-RXN xref: RHEA:18904 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047414 name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H(2)O + H(+) = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO(2) + NH(4)(+)." [EC:3.5.1.66, RHEA:17680] synonym: "2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.66] synonym: "alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.66] synonym: "compound B hydrolase activity" EXACT [EC:3.5.1.66] xref: EC:3.5.1.66 xref: KEGG:R04397 xref: MetaCyc:3.5.1.66-RXN xref: RHEA:17680 xref: Wikipedia:2-(hydroxymethyl)-3-(acetamidomethylene)succinate_amidohydrolase_(deaminating\,_decarboxylating) is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047415 name: D-benzoylarginine-4-nitroanilide amidase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H(2)O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H(+)." [EC:3.5.1.72, RHEA:14424] synonym: "benzoyl-D-arginine arylamidase activity" EXACT [EC:3.5.1.72] synonym: "D-BAPA-ase activity" EXACT [EC:3.5.1.72] synonym: "N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity" EXACT [EC:3.5.1.72] xref: EC:3.5.1.72 xref: KEGG:R04113 xref: MetaCyc:3.5.1.72-RXN xref: RHEA:14424 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047416 name: arylalkyl acylamidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine." [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN] subset: gosubset_prok synonym: "aralkyl acylamidase activity" EXACT [EC:3.5.1.76] synonym: "N-acetylarylalkylamine amidohydrolase activity" EXACT [EC:3.5.1.76] xref: EC:3.5.1.76 xref: MetaCyc:3.5.1.76-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047417 name: N-carbamoyl-D-amino acid hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid." [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN] subset: gosubset_prok synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.77] xref: EC:3.5.1.77 xref: MetaCyc:3.5.1.77-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047418 name: phthalyl amidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine." [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN] synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79] synonym: "phthalyl-amide amidohydrolase activity" EXACT [EC:3.5.1.79] xref: EC:3.5.1.79 xref: MetaCyc:3.5.1.79-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047419 name: N-acetylgalactosamine-6-phosphate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [EC:3.5.1.-, MetaCyc:3.5.1.80-RXN] xref: EC:3.5.1.- xref: MetaCyc:3.5.1.80-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047420 name: N-acyl-D-amino-acid deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid." [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN] subset: gosubset_prok synonym: "D-aminoacylase activity" EXACT [EC:3.5.1.81] synonym: "N-acyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.81] xref: EC:3.5.1.81 xref: MetaCyc:3.5.1.81-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047421 name: N-acyl-D-glutamate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-glutamate + H(2)O = D-glutamate + a carboxylate." [EC:3.5.1.82, RHEA:12836] subset: gosubset_prok synonym: "N-acyl-D-glutamate amidohydrolase activity" EXACT [EC:3.5.1.82] xref: EC:3.5.1.82 xref: KEGG:R01581 xref: MetaCyc:3.5.1.82-RXN xref: RHEA:12836 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047422 name: N-acyl-D-aspartate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-aspartate + H(2)O = D-aspartate + a carboxylate." [EC:3.5.1.83, RHEA:18288] subset: gosubset_prok synonym: "N-acyl-D-aspartate amidohydrolase activity" EXACT [EC:3.5.1.83] xref: EC:3.5.1.83 xref: KEGG:R02182 xref: MetaCyc:3.5.1.83-RXN xref: RHEA:18288 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047423 name: N-methylhydantoinase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: N-methylhydantoin + ATP + 2 H(2)O = N-carbamoylsarcosine + ADP + 3 H(+) + phosphate." [EC:3.5.2.14, RHEA:11723] subset: gosubset_prok synonym: "methylhydantoin amidase activity" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoin hydrolase activity" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoinase (ATP-hydrolysing)" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoinase activity" EXACT [EC:3.5.2.14] synonym: "N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.14] xref: EC:3.5.2.14 xref: KEGG:R03187 xref: MetaCyc:3.5.2.14-RXN xref: RHEA:11723 xref: Wikipedia:N-methylhydantoinase_(ATP-hydrolysing) is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047424 name: methylenediurea deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea." [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN] subset: gosubset_prok synonym: "methylenediurea aminohydrolase activity" EXACT [EC:3.5.3.21] synonym: "methylenediurease activity" EXACT [EC:3.5.3.21] xref: EC:3.5.3.21 xref: MetaCyc:3.5.3.21-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047425 name: 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H(2)O + H(+) = 2,5-dioxopentanoate + NH(4)(+)." [EC:3.5.4.22, RHEA:10563] synonym: "1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)" EXACT [EC:3.5.4.22] synonym: "HPC deaminase activity" EXACT [EC:3.5.4.22] xref: EC:3.5.4.22 xref: KEGG:R02280 xref: MetaCyc:3.5.4.22-RXN xref: RHEA:10563 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047426 name: ricinine nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone." [EC:3.5.5.2, MetaCyc:3.5.5.2-RXN] synonym: "ricinine aminohydrolase activity" EXACT [EC:3.5.5.2] xref: EC:3.5.5.2 xref: MetaCyc:3.5.5.2-RXN is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0047427 name: cyanoalanine nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 3-cyano-L-alanine + 2 H(2)O + H(+) = L-aspartate + NH(4)(+)." [EC:3.5.5.4, RHEA:25310] synonym: "3-cyano-L-alanine aminohydrolase activity" EXACT [EC:3.5.5.4] synonym: "beta-cyanoalanine nitrilase activity" EXACT [EC:3.5.5.4] xref: EC:3.5.5.4 xref: KEGG:R00486 xref: MetaCyc:3.5.5.4-RXN xref: RHEA:25310 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0047428 name: arylacetonitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3." [EC:3.5.5.5, MetaCyc:3.5.5.5-RXN] synonym: "arylacetonitrile aminohydrolase activity" EXACT [EC:3.5.5.5] xref: EC:3.5.5.5 xref: MetaCyc:3.5.5.5-RXN is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0047429 name: nucleoside-triphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide." [EC:3.6.1.19, MetaCyc:3.6.1.19-RXN] subset: gosubset_prok synonym: "nucleoside-triphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.19] synonym: "nucleoside-triphosphate pyrophosphatase activity" EXACT [] xref: EC:3.6.1.19 xref: MetaCyc:3.6.1.19-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047430 name: oligosaccharide-diphosphodolichol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate." [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN] synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" EXACT [EC:3.6.1.44] synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT [] xref: EC:3.6.1.44 xref: MetaCyc:3.6.1.44-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047431 name: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 5-hydroxy-6-methylpyridine-3-carboxylate + CO(2)." [EC:4.1.1.51, RHEA:13672] synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)" EXACT [EC:4.1.1.51] synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity" EXACT [EC:4.1.1.51] xref: EC:4.1.1.51 xref: KEGG:R03461 xref: MetaCyc:4.1.1.51-RXN xref: RHEA:13672 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047432 name: 2,2-dialkylglycine decarboxylase (pyruvate) activity namespace: molecular_function def: "Catalysis of the reaction: 2,2-dialkylglycine + H(+) + pyruvate = L-alanine + CO(2) + dialkyl ketone." [EC:4.1.1.64, RHEA:16076] subset: gosubset_prok synonym: "2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity" EXACT [EC:4.1.1.64] synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring)" EXACT [EC:4.1.1.64] synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)" EXACT [EC:4.1.1.64] synonym: "alpha-dialkyl amino acid transaminase activity" EXACT [EC:4.1.1.64] synonym: "dialkyl amino acid (pyruvate) decarboxylase activity" EXACT [EC:4.1.1.64] synonym: "dialkylamino-acid decarboxylase (pyruvate)" EXACT [EC:4.1.1.64] synonym: "L-alanine-alpha-ketobutyrate aminotransferase activity" EXACT [EC:4.1.1.64] xref: EC:4.1.1.64 xref: KEGG:R03854 xref: MetaCyc:4.1.1.64-RXN xref: RHEA:16076 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047433 name: branched-chain-2-oxoacid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2)." [EC:4.1.1.72, RHEA:21111] synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)" EXACT [EC:4.1.1.72] synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.72] synonym: "BCKA" RELATED [EC:4.1.1.72] synonym: "branched-chain alpha-keto acid decarboxylase activity" EXACT [EC:4.1.1.72] synonym: "branched-chain keto acid decarboxylase activity" EXACT [EC:4.1.1.72] synonym: "branched-chain oxo acid decarboxylase activity" EXACT [EC:4.1.1.72] xref: EC:4.1.1.72 xref: KEGG:R03894 xref: MetaCyc:4.1.1.72-RXN xref: RHEA:21111 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047434 name: indolepyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde." [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN] subset: gosubset_prok synonym: "3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]" RELATED [EC:4.1.1.74] synonym: "3-(indol-3-yl)pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74] synonym: "indol-3-yl-pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74] synonym: "indole-3-pyruvate decarboxylase activity" EXACT [EC:4.1.1.74] xref: EC:4.1.1.74 xref: MetaCyc:4.1.1.74-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047435 name: 5-guanidino-2-oxopentanoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO(2)." [EC:4.1.1.75, RHEA:11343] synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)" EXACT [EC:4.1.1.75] synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.75] synonym: "2-oxo-5-guanidinopentanoate decarboxylase activity" EXACT [EC:4.1.1.75] synonym: "2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75] synonym: "alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75] xref: EC:4.1.1.75 xref: KEGG:R03178 xref: MetaCyc:4.1.1.75-RXN xref: RHEA:11343 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047436 name: arylmalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO(2)." [EC:4.1.1.76, RHEA:20516] subset: gosubset_prok synonym: "2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)" EXACT [EC:4.1.1.76] synonym: "2-aryl-2-methylmalonate carboxy-lyase activity" EXACT [EC:4.1.1.76] synonym: "AMDASE" RELATED [EC:4.1.1.76] synonym: "AMDase activity" EXACT [EC:4.1.1.76] xref: EC:4.1.1.76 xref: KEGG:R05173 xref: MetaCyc:4.1.1.76-RXN xref: RHEA:20516 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047437 name: 4-oxalocrotonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate." [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN] subset: gosubset_prok synonym: "4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.1.1.77] synonym: "4-oxalocrotonate carboxy-lyase activity" EXACT [EC:4.1.1.77] xref: EC:4.1.1.77 xref: MetaCyc:4.1.1.77-RXN xref: UM-BBD_reactionID:r1435 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047438 name: 2-dehydro-3-deoxy-L-pentonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN] synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.18] synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.18] synonym: "2-keto-3-deoxy-D-xylonate aldolase activity" EXACT [EC:4.1.2.18] synonym: "2-keto-3-deoxy-L-arabonate aldolase activity" NARROW [EC:4.1.2.18] synonym: "2-keto-3-deoxy-L-pentonate aldolase activity" EXACT [EC:4.1.2.18] synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.18] xref: EC:4.1.2.18 xref: MetaCyc:4.1.2.18-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047439 name: 3-deoxy-D-manno-octulosonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate." [EC:4.1.2.23, RHEA:23343] synonym: "2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:4.1.2.23] synonym: "2-keto-3-deoxyoctonic aldolase activity" EXACT [EC:4.1.2.23] synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)" EXACT [EC:4.1.2.23] synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase activity" EXACT [EC:4.1.2.23] synonym: "3-deoxy-D-manno-octulosonic aldolase activity" EXACT [EC:4.1.2.23] synonym: "3-deoxyoctulosonic aldolase activity" EXACT [EC:4.1.2.23] synonym: "KDOaldolase activity" EXACT [EC:4.1.2.23] xref: EC:4.1.2.23 xref: KEGG:R01576 xref: MetaCyc:4.1.2.23-RXN xref: RHEA:23343 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047440 name: 2-dehydro-3-deoxy-D-pentonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate." [EC:4.1.2.28, RHEA:20612] synonym: "2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.28] synonym: "2-keto-3-deoxy-D-pentonate aldolase activity" EXACT [EC:4.1.2.28] synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.28] xref: EC:4.1.2.28 xref: KEGG:R01782 xref: MetaCyc:4.1.2.28-RXN xref: RHEA:20612 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047441 name: 5-dehydro-2-deoxyphosphogluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate." [EC:4.1.2.29, RHEA:13180] synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.29] synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity" EXACT [EC:4.1.2.29] synonym: "phospho-5-dehydro-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29] synonym: "phospho-5-keto-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29] xref: EC:4.1.2.29 xref: KEGG:R05378 xref: MetaCyc:4.1.2.29-RXN xref: RHEA:13180 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047442 name: 17-alpha-hydroxyprogesterone aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione." [EC:4.1.2.30, MetaCyc:4.1.2.30-RXN] synonym: "17-alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30] synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)" EXACT [EC:4.1.2.30] synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30] synonym: "17alpha-hydroxyprogesterone aldolase activity" EXACT [EC:4.1.2.30] synonym: "C-17/C-20 lyase activity" EXACT [EC:4.1.2.30] xref: EC:4.1.2.30 xref: MetaCyc:4.1.2.30-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047443 name: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate." [EC:4.1.3.17, MetaCyc:4.1.3.17-RXN] subset: gosubset_prok synonym: "4-hydroxy-4-methyl-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.17] synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.17] synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity" EXACT [EC:4.1.3.17] synonym: "gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity" EXACT [EC:4.1.3.17] synonym: "pyruvate aldolase activity" EXACT [EC:4.1.3.17] xref: EC:4.1.3.17 xref: MetaCyc:4.1.3.17-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047444 name: N-acylneuraminate-9-phosphate synthase activity namespace: molecular_function alt_id: GO:0019007 def: "Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate." [EC:2.5.1.57, MetaCyc:4.1.3.20-RXN] synonym: "N-acetylneuraminate 9-phosphate lyase activity" EXACT [EC:2.5.1.57] synonym: "N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity" EXACT [EC:2.5.1.57] synonym: "N-acetylneuraminate 9-phosphate synthetase activity" EXACT [EC:2.5.1.57] synonym: "N-acetylneuraminic acid phosphate synthase activity" EXACT [GOC:mah] synonym: "N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.57] synonym: "phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity" EXACT [EC:2.5.1.57] synonym: "sialic acid 9-phosphate synthetase activity" EXACT [EC:2.5.1.57] xref: EC:2.5.1.57 xref: MetaCyc:4.1.3.20-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047445 name: 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H(+) = 7-methyl-3-oxooct-6-enoyl-CoA + acetate." [EC:4.1.3.26, RHEA:23087] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)" EXACT [EC:4.1.3.26] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity" EXACT [EC:4.1.3.26] synonym: "3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.26] synonym: "3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity" EXACT [EC:4.1.3.26] synonym: "beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity" EXACT [EC:4.1.3.26] synonym: "hydroxyisohexenylglutaryl-CoA:acetatelyase activity" EXACT [EC:4.1.3.26] xref: EC:4.1.3.26 xref: KEGG:R08090 xref: MetaCyc:4.1.3.26-RXN xref: RHEA:23087 xref: UM-BBD_reactionID:r1168 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047446 name: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone." [EC:4.1.3.35, RHEA:23871] synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.35] synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity" EXACT [EC:4.1.3.35] xref: EC:4.1.3.35 xref: KEGG:R02232 xref: MetaCyc:4.1.3.35-RXN xref: RHEA:23871 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047447 name: erythro-3-hydroxyaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid." [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN] synonym: "3-hydroxyaspartate dehydratase activity" BROAD [EC:4.3.1.20] synonym: "erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxyaspartate dehydratase activity" EXACT [] synonym: "erythro-beta-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.20] xref: EC:4.3.1.20 xref: MetaCyc:4.3.1.20-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047448 name: 5-dehydro-4-deoxyglucarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO(2) + H(2)O." [EC:4.2.1.41, RHEA:24611] subset: gosubset_prok synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.41] synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.41] synonym: "5-keto-4-deoxy-glucarate dehydratase activity" EXACT [EC:4.2.1.41] synonym: "D-4-deoxy-5-ketoglucarate hydro-lyase activity" EXACT [EC:4.2.1.41] synonym: "deoxyketoglucarate dehydratase activity" EXACT [EC:4.2.1.41] xref: EC:4.2.1.41 xref: KEGG:R02279 xref: MetaCyc:4.2.1.41-RXN xref: RHEA:24611 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047449 name: 2-dehydro-3-deoxy-L-arabinonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O." [EC:4.2.1.43, RHEA:17204] synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.43] synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.43] synonym: "2-keto-3-deoxy-L-arabinonate dehydratase activity" EXACT [EC:4.2.1.43] xref: EC:4.2.1.43 xref: KEGG:R02278 xref: MetaCyc:4.2.1.43-RXN xref: RHEA:17204 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047450 name: crotonoyl-[acyl-carrier-protein] hydratase activity namespace: molecular_function alt_id: GO:0080063 def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]." [EC:4.2.1.58, MetaCyc:4.2.1.58-RXN] synonym: "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.58] synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.58] synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.58] synonym: "3-hydroxybutyryl acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.58] synonym: "beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" EXACT [EC:4.2.1.58] synonym: "beta-hydroxybutyryl acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.58] synonym: "crotonoyl-[acyl-carrier protein] hydratase activity" EXACT [] synonym: "crotonoyl-ACP hydratase activity" EXACT [] synonym: "crotonoyl-acyl-carrier-protein hydratase activity" EXACT [EC:4.2.1.58] synonym: "crotonyl acyl carrier protein hydratase activity" EXACT [EC:4.2.1.58] synonym: "enoyl acyl carrier protein hydrase activity" EXACT [EC:4.2.1.58] xref: EC:4.2.1.58 xref: KEGG:R04428 xref: MetaCyc:4.2.1.58-RXN is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0047451 name: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN] synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.59] synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.59] synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.59] synonym: "3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxyoctanoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyoctanoyl thioester dehydratase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyoctanoyl-ACP-dehydrase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.59] xref: EC:4.2.1.59 xref: KEGG:R04537 xref: MetaCyc:4.2.1.59-RXN is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0047452 name: protoaphin-aglucone dehydratase (cyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: protoaphin aglucone = H(2)O + xanthoaphin." [EC:4.2.1.73, RHEA:23879] synonym: "protoaphin dehydratase (cyclizing)" EXACT [EC:4.2.1.73] synonym: "protoaphin dehydratase activity" EXACT [EC:4.2.1.73] synonym: "protoaphin-aglucone hydro-lyase (cyclizing)" EXACT [EC:4.2.1.73] synonym: "protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)" EXACT [EC:4.2.1.73] xref: EC:4.2.1.73 xref: KEGG:R03742 xref: MetaCyc:4.2.1.73-RXN xref: RHEA:23879 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047453 name: ATP-dependent NAD(P)H-hydrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate." [EC:4.2.1.93, RHEA:19020] synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)" EXACT [EC:4.2.1.93] synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.93] synonym: "ATP-dependent H(4)NAD(P)OH dehydratase activity" EXACT [] synonym: "ATP-dependent H4NAD(P)OH dehydratase activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" EXACT [EC:4.2.1.93] xref: EC:4.2.1.93 xref: KEGG:R00129 xref: MetaCyc:4.2.1.93-RXN xref: RHEA:19020 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047454 name: phaseollidin hydratase activity namespace: molecular_function def: "Catalysis of the reaction: phaseollidin hydrate = H(2)O + phaseollidin." [EC:4.2.1.97, RHEA:19772] synonym: "phaseollidin-hydrate hydro-lyase (phaseollidin-forming)" EXACT [EC:4.2.1.97] synonym: "phaseollidin-hydrate hydro-lyase activity" EXACT [EC:4.2.1.97] xref: EC:4.2.1.97 xref: KEGG:R04728 xref: MetaCyc:4.2.1.97-RXN xref: RHEA:19772 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047455 name: 16-alpha-hydroxyprogesterone dehydratase activity namespace: molecular_function alt_id: GO:0047523 def: "Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone." [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN] synonym: "16-alpha-dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16-alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16-dehydroprogesterone hydratase activity" RELATED [] synonym: "16alpha-dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone dehydratase activity" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone hydro-lyase activity" EXACT [EC:4.2.1.98] synonym: "hydroxyprogesterone dehydroxylase activity" EXACT [] xref: EC:4.2.1.98 xref: MetaCyc:4.2.1.98-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047456 name: 2-methylisocitrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H(2)O." [EC:4.2.1.99, RHEA:17944] subset: gosubset_prok synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.99] synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.99] xref: EC:4.2.1.99 xref: KEGG:R04425 xref: MetaCyc:4.2.1.99-RXN xref: RHEA:17944 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047457 name: exo-(1,4)-alpha-D-glucan lyase activity namespace: molecular_function def: "Catalysis of the reaction: linear alpha-glucan = 1,5-anhydro-D-fructose + beta-D-glucose." [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN] synonym: "(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)" EXACT [EC:4.2.2.13] synonym: "alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13] synonym: "alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13] synonym: "alpha-1,4-glucan exo-lyase activity" EXACT [EC:4.2.2.13] synonym: "alpha-1,4-glucan lyase activity" BROAD [EC:4.2.2.13] synonym: "exo-(1->4)-alpha-D-glucan lyase activity" EXACT [EC:4.2.2.13] synonym: "exo-alpha-1,4-glucan lyase activity" EXACT [EC:4.2.2.13] xref: EC:4.2.2.13 xref: MetaCyc:4.2.2.13-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047458 name: beta-pyrazolylalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)." [EC:2.5.1.51, RHEA:13120] synonym: "3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51] synonym: "beta-(1-pyrazolyl)alanine synthase activity" EXACT [EC:2.5.1.51] synonym: "beta-pyrazolealanine synthase activity" EXACT [EC:2.5.1.51] synonym: "beta-pyrazolylalanine synthase (acetylserine) activity" EXACT [] synonym: "BPA-synthase activity" EXACT [EC:2.5.1.51] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity" EXACT [EC:2.5.1.51] synonym: "O3-acetyl-L-serine acetate-lyase (adding pyrazole)" EXACT [EC:2.5.1.51] synonym: "O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51] synonym: "pyrazolealanine synthase activity" EXACT [EC:2.5.1.51] synonym: "pyrazolylalaninase activity" EXACT [EC:2.5.1.51] xref: EC:2.5.1.51 xref: KEGG:R03134 xref: MetaCyc:2.5.1.51-RXN xref: RHEA:13120 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047459 name: 3-aminobutyryl-CoA ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH(4)(+)." [EC:4.3.1.14, RHEA:10059] synonym: "L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.3.1.14] synonym: "L-3-aminobutyryl-CoA ammonia-lyase activity" EXACT [EC:4.3.1.14] synonym: "L-3-aminobutyryl-CoA deaminase activity" EXACT [EC:4.3.1.14] xref: EC:4.3.1.14 xref: KEGG:R03030 xref: MetaCyc:4.3.1.14-RXN xref: RHEA:10059 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047460 name: L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H(2)O = 2-oxopent-4-enoate + chloride + H(+) + NH(4)(+)." [EC:4.5.1.4, RHEA:11623] synonym: "L-2-amino-4-chloro-4-pentenoate dehalogenase activity" EXACT [EC:4.5.1.4] synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)" EXACT [EC:4.5.1.4] synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)" EXACT [EC:4.5.1.4] xref: EC:4.5.1.4 xref: KEGG:R02605 xref: MetaCyc:4.5.1.4-RXN xref: RHEA:11623 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0047461 name: (+)-delta-cadinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene." [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)" EXACT [EC:4.2.3.13] synonym: "D-cadinene synthase activity" EXACT [EC:4.2.3.13] xref: EC:4.2.3.13 xref: MetaCyc:4.6.1.11-RXN is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0047462 name: phenylalanine racemase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+)." [EC:5.1.1.11, RHEA:20204] subset: gosubset_prok synonym: "gramicidin S synthetase I" RELATED [EC:5.1.1.11] synonym: "phenylalanine racemase (adenosine triphosphate-hydrolysing)" EXACT [EC:5.1.1.11] synonym: "phenylalanine racemase (ATP-hydrolysing)" BROAD [EC:5.1.1.11] synonym: "phenylalanine racemase activity" EXACT [EC:5.1.1.11] xref: EC:5.1.1.11 xref: KEGG:R00686 xref: MetaCyc:5.1.1.11-RXN xref: RHEA:20204 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0047463 name: 2-aminohexano-6-lactam racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam." [EC:5.1.1.15, RHEA:14816] synonym: "2-amino-hexano-6-lactam racemase activity" EXACT [EC:5.1.1.15] synonym: "alpha-amino-epsilon-caprolactam racemase activity" EXACT [EC:5.1.1.15] xref: EC:5.1.1.15 xref: KEGG:R04736 xref: MetaCyc:5.1.1.15-RXN xref: RHEA:14816 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0047464 name: heparosan-N-sulfate-glucuronate 5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN] synonym: "C-5 uronosyl epimerase activity" EXACT [EC:5.1.3.17] synonym: "D-glucuronyl C-5 epimerase activity" EXACT [EC:5.1.3.17] synonym: "heparosan epimerase activity" EXACT [EC:5.1.3.17] synonym: "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.17] synonym: "heparosan-N-sulphate-glucuronate 5-epimerase activity" EXACT [] synonym: "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity" EXACT [EC:5.1.3.17] synonym: "polyglucuronate epimerase activity" EXACT [EC:5.1.3.17] xref: EC:5.1.3.17 xref: MetaCyc:5.1.3.17-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047465 name: N-acylglucosamine-6-phosphate 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate." [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN] subset: gosubset_prok synonym: "acylglucosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "acylglucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "acylmannosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "N-acetylglucosmamine 6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "N-acetylmannosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "N-acyl-D-glucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] xref: EC:5.1.3.9 xref: MetaCyc:5.1.3.9-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047466 name: 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity namespace: molecular_function alt_id: GO:0018840 def: "Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide." [EC:5.2.1.10, RHEA:10927] synonym: "2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity" EXACT [EC:5.2.1.10] synonym: "2-chlorocarboxymethylenebutenolide isomerase activity" EXACT [EC:5.2.1.-] synonym: "chlorodienelactone isomerase activity" EXACT [EC:5.2.1.-] xref: EC:5.2.1.10 xref: KEGG:R04576 xref: MetaCyc:5.2.1.10-RXN xref: RHEA:10927 xref: UM-BBD_reactionID:r0278 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0047467 name: 4-hydroxyphenylacetaldehyde-oxime isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime." [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN] is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0047468 name: phosphoglucomutase (glucose-cofactor) activity namespace: molecular_function def: "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor." [EC:5.4.2.5, MetaCyc:5.4.2.5-RXN] synonym: "alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)" EXACT [EC:5.4.2.5] synonym: "glucose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.5] xref: EC:5.4.2.5 xref: MetaCyc:5.4.2.5-RXN is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0047469 name: 4-carboxymethyl-4-methylbutenolide mutase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide." [EC:5.4.99.14, RHEA:19240] synonym: "4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity" EXACT [EC:5.4.99.14] synonym: "4-methyl-2-enelactone isomerase activity" EXACT [EC:5.4.99.14] synonym: "4-methyl-2-enelactone methyl-isomerase activity" EXACT [EC:5.4.99.14] synonym: "4-methyl-3-enelactone methyl isomerase activity" EXACT [EC:5.4.99.14] synonym: "4-methylmuconolactone methylisomerase activity" EXACT [EC:5.4.99.14] xref: EC:5.4.99.14 xref: KEGG:R04510 xref: MetaCyc:5.4.99.14-RXN xref: RHEA:19240 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047470 name: (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(1,4-alpha-D-glucosyl)(n-1)-D-glucose = 1-alpha-D-(1,4-alpha-D-glucosyl)(n-1)-alpha-D-glucopyranoside." [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN] subset: gosubset_prok synonym: "(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase" BROAD [EC:5.4.99.15] synonym: "malto-oligosyltrehalose synthase activity" EXACT [EC:5.4.99.15] synonym: "maltodextrin alpha-D-glucosyltransferase activity" EXACT [EC:5.4.99.15] xref: EC:5.4.99.15 xref: MetaCyc:5.4.99.15-RXN xref: Reactome:77954 "(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity" is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047471 name: maltose alpha-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: maltose = trehalose." [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN] subset: gosubset_prok synonym: "maltose alpha-D-glucosylmutase activity" EXACT [EC:5.4.99.16] synonym: "maltose glucosylmutase activity" EXACT [EC:5.4.99.16] synonym: "trehalose synthase activity" EXACT [EC:5.4.99.16] xref: EC:5.4.99.16 xref: MetaCyc:5.4.99.16-RXN xref: Reactome:77956 "maltose alpha-D-glucosyltransferase activity" is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047472 name: 3-carboxy-cis,cis-muconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)." [EC:5.5.1.2, RHEA:23659] subset: gosubset_prok synonym: "2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.2] synonym: "3-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2] synonym: "3-carboxymuconolactone hydrolase activity" EXACT [EC:5.5.1.2] synonym: "beta-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2] synonym: "CMLE activity" EXACT [EC:5.5.1.2] xref: EC:5.5.1.2 xref: KEGG:R03307 xref: MetaCyc:5.5.1.2-RXN xref: RHEA:23659 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0047473 name: D-alanine-poly(phosphoribitol) ligase activity namespace: molecular_function def: "Catalysis of the reaction: poly(ribitol phosphate) + D-alanine + ATP = O-D-alanyl-poly(ribitol phosphate) + diphosphate + AMP." [EC:6.1.1.13, MetaCyc:6.1.1.13-RXN] subset: gosubset_prok synonym: "D-alanine-activating enzyme activity" RELATED [EC:6.1.1.13] synonym: "D-alanine-D-alanyl carrier protein ligase activity" EXACT [EC:6.1.1.13] synonym: "D-alanine-membrane acceptor ligase activity" EXACT [EC:6.1.1.13] synonym: "D-alanine: membrane acceptor ligase activity" EXACT [EC:6.1.1.13] synonym: "D-alanine:poly(phosphoribitol) ligase (AMP-forming)" EXACT [EC:6.1.1.13] synonym: "D-alanyl-poly(phosphoribitol) synthetase activity" EXACT [EC:6.1.1.13] xref: EC:6.1.1.13 xref: MetaCyc:6.1.1.13-RXN is_a: GO:0016876 ! ligase activity, forming aminoacyl-tRNA and related compounds [Term] id: GO:0047474 name: long-chain fatty acid luciferin component ligase activity namespace: molecular_function def: "Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP." [EC:6.2.1.19, MetaCyc:6.2.1.19-RXN] subset: gosubset_prok synonym: "acyl-protein synthetase activity" RELATED [EC:6.2.1.19] synonym: "long-chain-fatty-acid luciferin component ligase activity" EXACT [GOC:mah] synonym: "long-chain-fatty-acid-luciferin-component ligase activity" EXACT [] synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" EXACT [EC:6.2.1.19] xref: EC:6.2.1.19 xref: MetaCyc:6.2.1.19-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047475 name: phenylacetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H(+) + phenylacetyl-CoA." [EC:6.2.1.30, RHEA:20959] subset: gosubset_prok synonym: "PA-CoA ligase activity" EXACT [EC:6.2.1.30] synonym: "phenacyl coenzyme A synthetase activity" EXACT [EC:6.2.1.30] synonym: "phenylacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30] synonym: "phenylacetyl-CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30] synonym: "phenylacetyl-CoA ligase activity" EXACT [EC:6.2.1.30] xref: EC:6.2.1.30 xref: KEGG:R02539 xref: MetaCyc:PHENYLACETATE--COA-LIGASE-RXN xref: RHEA:20959 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047476 name: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP." [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN] synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.28] synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.28] synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.28] synonym: "DHCA-CoA ligase activity" EXACT [EC:6.2.1.28] xref: EC:6.2.1.28 xref: MetaCyc:6.2.1.28-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047478 name: aspartate-ammonia ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + ATP + NH(4)(+) = L-asparagine + ADP + 2 H(+) + phosphate." [EC:6.3.1.4, RHEA:14200] synonym: "asparagine synthetase (adenosine diphosphate-forming)" EXACT [EC:6.3.1.4] synonym: "asparagine synthetase (ADP-forming) activity" EXACT [EC:6.3.1.4] synonym: "L-aspartate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.4] xref: EC:6.3.1.4 xref: KEGG:R00482 xref: MetaCyc:6.3.1.4-RXN xref: RHEA:14200 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0047479 name: trypanothione synthase activity namespace: molecular_function def: "Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate." [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN] synonym: "glutathionylspermidine:glutathione ligase (ADP-forming)" EXACT [EC:6.3.1.9] synonym: "TSR synthetase activity" EXACT [EC:6.3.1.9] xref: EC:6.3.1.9 xref: MetaCyc:6.3.1.9-RXN is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0047480 name: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP." [EC:6.3.2.10, MetaCyc:6.3.2.10-RXN] comment: Note that the enzyme UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase also has UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766). subset: gosubset_prok synonym: "MurF synthetase activity" RELATED [EC:6.3.2.10] synonym: "UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-MurNAc-pentapeptide synthetase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [] synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity" EXACT [] synonym: "UDPacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10] synonym: "uridine diphosphoacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10] xref: EC:6.3.2.10 xref: MetaCyc:6.3.2.10-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047481 name: D-alanine-alanyl-poly(glycerolphosphate) ligase activity namespace: molecular_function def: "Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP." [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN] synonym: "D-alanine-membrane acceptor-ligase activity" EXACT [EC:6.3.2.16] synonym: "D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)" EXACT [EC:6.3.2.16] synonym: "D-alanine:membrane-acceptor ligase activity" EXACT [EC:6.3.2.16] synonym: "D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity" EXACT [EC:6.3.2.16] synonym: "D-alanyl-poly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16] synonym: "D-alanylalanylpoly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16] xref: EC:6.3.2.16 xref: MetaCyc:6.3.2.16-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047482 name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine." [EC:6.3.2.7, RHEA:17972] subset: gosubset_prok synonym: "L-lysine-adding enzyme activity" RELATED [EC:6.3.2.7] synonym: "MurE synthetase activity" RELATED [EC:6.3.2.7] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.7] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity" EXACT [EC:6.3.2.7] synonym: "UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity" EXACT [EC:6.3.2.7] synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity" EXACT [EC:6.3.2.7] xref: EC:6.3.2.7 xref: KEGG:R02786 xref: MetaCyc:6.3.2.7-RXN xref: RHEA:17972 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047483 name: imidazoleacetate-phosphoribosyldiphosphate ligase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H(+) + phosphate." [EC:6.3.4.8, RHEA:16488] synonym: "5-phosphoribosylimidazoleacetate synthetase activity" EXACT [EC:6.3.4.8] synonym: "imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)" EXACT [EC:6.3.4.8] xref: EC:6.3.4.8 xref: KEGG:R04068 xref: MetaCyc:6.3.4.8-RXN xref: RHEA:16488 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0047484 name: regulation of response to osmotic stress namespace: biological_process def: "Any process that modulates the rate or extent of the response to osmotic stress." [GOC:ai] is_a: GO:0080134 ! regulation of response to stress relationship: regulates GO:0006970 ! response to osmotic stress [Term] id: GO:0047485 name: protein N-terminus binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "amino-terminal binding" RELATED [GOC:jsg] synonym: "amino-terminus binding" RELATED [GOC:jsg] synonym: "N-terminal binding" EXACT [] synonym: "N-terminal end binding" EXACT [GOC:jsg] synonym: "NH2-terminal binding" NARROW [GOC:jsg] synonym: "NH2-terminus binding" NARROW [GOC:jsg] is_a: GO:0005515 ! protein binding [Term] id: GO:0047486 name: chondroitin ABC lyase activity namespace: molecular_function def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.4] subset: gosubset_prok xref: EC:4.2.2.4 is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047487 name: oligogalacturonide lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(4-deoxy-beta-D-gluc-4-enuronosyl)-D-galacturonate = 25-dehydro-4-deoxy-D-glucuronate." [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN] subset: gosubset_prok synonym: "OGTE" RELATED [EC:4.2.2.6] synonym: "oligogalacturonate lyase activity" EXACT [EC:4.2.2.6] synonym: "unsaturated oligogalacturonate transeliminase activity" EXACT [EC:4.2.2.6] xref: EC:4.2.2.6 xref: MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047488 name: heparin lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN] subset: gosubset_prok synonym: "heparan sulfate lyase activity" RELATED [] synonym: "heparin eliminase activity" RELATED [EC:4.2.2.7] synonym: "heparinase activity" EXACT [EC:4.2.2.7] xref: EC:4.2.2.7 xref: MetaCyc:4.2.2.7-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047489 name: pectate disaccharide-lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of 4-(4-deoxy-a-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin." [EC:4.2.2.9] subset: gosubset_prok synonym: "(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity" EXACT [EC:4.2.2.9] synonym: "exo-PATE" RELATED [EC:4.2.2.9] synonym: "Exo-PATE activity" EXACT [EC:4.2.2.9] synonym: "exo-PGL" RELATED [EC:4.2.2.9] synonym: "Exo-PGL activity" EXACT [EC:4.2.2.9] synonym: "exopectate lyase activity" EXACT [EC:4.2.2.9] synonym: "exopectic acid transeliminase activity" EXACT [EC:4.2.2.9] synonym: "exopolygalacturonate lyase activity" EXACT [EC:4.2.2.9] synonym: "exopolygalacturonic acid-trans-eliminase activity" EXACT [EC:4.2.2.9] synonym: "PATE activity" EXACT [EC:4.2.2.9] synonym: "pectate exo-lyase activity" EXACT [EC:4.2.2.9] xref: EC:4.2.2.9 xref: MetaCyc:4.2.2.9-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047490 name: pectin lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of (14)-a-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-a-D-galact-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.10] subset: gosubset_prok synonym: "(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.10] synonym: "endo-pectin lyase activity" EXACT [EC:4.2.2.10] synonym: "pectin methyltranseliminase activity" EXACT [EC:4.2.2.10] synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.10] synonym: "pectolyase activity" EXACT [EC:4.2.2.10] synonym: "PL activity" EXACT [EC:4.2.2.10] synonym: "PMGL activity" EXACT [EC:4.2.2.10] synonym: "PNL activity" EXACT [EC:4.2.2.10] synonym: "polymethylgalacturonic transeliminase activity" EXACT [EC:4.2.2.10] xref: EC:4.2.2.10 xref: MetaCyc:4.2.2.10-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047491 name: poly(alpha-L-guluronate) lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.11] subset: gosubset_prok synonym: "alginase II activity" RELATED [EC:4.2.2.11] synonym: "guluronate lyase activity" EXACT [EC:4.2.2.11] synonym: "L-guluronan lyase activity" EXACT [EC:4.2.2.11] synonym: "L-guluronate lyase activity" EXACT [EC:4.2.2.11] synonym: "poly(alpha-L-1,4-guluronide) exo-lyase activity" EXACT [EC:4.2.2.11] synonym: "poly-alpha-L-guluronate lyase activity" EXACT [EC:4.2.2.11] synonym: "polyguluronate-specific alginate lyase activity" EXACT [EC:4.2.2.11] xref: EC:4.2.2.11 xref: MetaCyc:4.2.2.11-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047492 name: xanthan lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of the terminal b-D-mannosyl-b-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-a-L-threo-hex-4-enuronosyl group at the terminus of the side-chain." [EC:4.2.2.12] xref: EC:4.2.2.12 xref: MetaCyc:4.2.2.12-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047493 name: ceramide cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin." [EC:2.7.8.3, RHEA:16276] subset: gosubset_prok synonym: "CDP-choline:N-acylsphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.3] synonym: "phosphorylcholine-ceramide transferase activity" EXACT [EC:2.7.8.3] xref: EC:2.7.8.3 xref: KEGG:R01891 xref: MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN xref: RHEA:16276 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047494 name: serine-phosphoethanolamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H(+)." [EC:2.7.8.4, RHEA:22659] synonym: "CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity" EXACT [EC:2.7.8.4] synonym: "serine ethanolamine phosphate synthetase activity" EXACT [EC:2.7.8.4] synonym: "serine ethanolamine phosphodiester synthase activity" EXACT [EC:2.7.8.4] synonym: "serine ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.4] synonym: "serine-phosphinico-ethanolamine synthase activity" EXACT [EC:2.7.8.4] synonym: "serinephosphoethanolamine synthase activity" EXACT [EC:2.7.8.4] xref: EC:2.7.8.4 xref: KEGG:R02563 xref: MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN xref: RHEA:22659 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047495 name: membrane-oligosaccharide glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another." [EC:2.7.8.21] synonym: "membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.21] synonym: "periplasmic phosphoglycerotransferase activity" NARROW [EC:2.7.8.21] synonym: "phosphoglycerol cyclase activity" RELATED [EC:2.7.8.21] xref: EC:2.7.8.21 xref: MetaCyc:2.7.8.21-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047496 name: vesicle transport along microtubule namespace: biological_process def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl] synonym: "microtubule-based vesicle localization" EXACT [GOC:rl] is_a: GO:0051648 ! vesicle localization is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0047497 name: mitochondrion transport along microtubule namespace: biological_process def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] synonym: "mitochondrial migration along microtubule" EXACT [] synonym: "mitochondrial transport along microtubule" EXACT [] is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0047498 name: calcium-dependent phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4] synonym: "calcium-dependent cytosolic phospholipase A2 activity" NARROW [] synonym: "calcium-dependent secreted phospholipase A2 activity" NARROW [] is_a: GO:0004623 ! phospholipase A2 activity [Term] id: GO:0047499 name: calcium-independent phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+." [EC:3.1.1.4] synonym: "calcium-independent cytosolic phospholipase A2 activity" NARROW [] is_a: GO:0004623 ! phospholipase A2 activity [Term] id: GO:0047500 name: (+)-borneol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-borneol + NAD(+) = (1R, 4R)-camphor + H(+) + NADH." [EC:1.1.1.198, RHEA:17332] synonym: "(+)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.198] synonym: "bicyclic monoterpenol dehydrogenase activity" EXACT [EC:1.1.1.198] xref: EC:1.1.1.198 xref: KEGG:R02944 xref: MetaCyc:+-BORNEOL-DEHYDROGENASE-RXN xref: RHEA:17332 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047501 name: (+)-neomenthol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-neomenthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH." [EC:1.1.1.208, RHEA:23815] synonym: "(+)-neomenthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.208] synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.208] xref: EC:1.1.1.208 xref: KEGG:R02548 xref: MetaCyc:+-NEOMENTHOL-DEHYDROGENASE-RXN xref: RHEA:23815 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047502 name: (+)-sabinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-cis-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH." [EC:1.1.1.228, RHEA:18332] synonym: "(+)-cis-sabinol dehydrogenase activity" EXACT [EC:1.1.1.228] synonym: "(+)-cis-sabinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.228] xref: EC:1.1.1.228 xref: KEGG:R03745 xref: MetaCyc:+-SABINOL-DEHYDROGENASE-RXN xref: RHEA:18332 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047503 name: (-)-borneol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH." [EC:1.1.1.227, RHEA:22131] synonym: "(-)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.227] xref: EC:1.1.1.227 xref: KEGG:R02945 xref: MetaCyc:--BORNEOL-DEHYDROGENASE-RXN xref: RHEA:22131 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047504 name: (-)-menthol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH." [EC:1.1.1.207, RHEA:13920] synonym: "(-)-menthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.207] synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.207] xref: EC:1.1.1.207 xref: KEGG:R02177 xref: MetaCyc:--MENTHOL-DEHYDROGENASE-RXN xref: RHEA:13920 xref: UM-BBD_reactionID:r1182 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047505 name: (-)-menthol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthol + H(+) + NADPH + O(2) = 1,4-menthane-3,8-diol + H(2)O + NADP(+)." [EC:1.14.13.46, RHEA:11651] synonym: "(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.46] synonym: "l-menthol monooxygenase activity" EXACT [EC:1.14.13.46] xref: EC:1.14.13.46 xref: KEGG:R02178 xref: MetaCyc:--MENTHOL-MONOOXYGENASE-RXN xref: RHEA:11651 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047506 name: (deoxy)adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dAMP = ADP + dADP." [EC:2.7.4.11, MetaCyc:DEOXYADENYLATE-KINASE-RXN] synonym: "ATP:(d)AMP phosphotransferase activity" EXACT [EC:2.7.4.11] xref: EC:2.7.4.11 xref: MetaCyc:DEOXYADENYLATE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047507 name: (deoxy)nucleoside-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate." [EC:2.7.4.13, MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN] synonym: "ATP:deoxynucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.13] synonym: "deoxynucleoside monophosphate kinase activity" EXACT [EC:2.7.4.13] synonym: "deoxynucleoside-5'-monophosphate kinase activity" EXACT [EC:2.7.4.13] synonym: "deoxyribonucleoside monophosphokinase activity" EXACT [EC:2.7.4.13] xref: EC:2.7.4.13 xref: MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: GO:0047508 name: (R)-2-methylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H(2)O." [EC:4.2.1.35, RHEA:22335] synonym: "(-)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.35] synonym: "(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)" EXACT [EC:4.2.1.35] synonym: "(R)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.35] synonym: "citraconase activity" EXACT [EC:4.2.1.35] synonym: "citraconate hydratase activity" EXACT [EC:4.2.1.35] synonym: "citramalate hydro-lyase activity" EXACT [EC:4.2.1.35] xref: EC:4.2.1.35 xref: KEGG:R03896 xref: MetaCyc:R-2-METHYLMALATE-DEHYDRATASE-RXN xref: RHEA:22335 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047509 name: (R)-dehydropantoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-4-dehydropantoate + H(2)O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH." [EC:1.2.1.33, RHEA:19352] synonym: "(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.2.1.33] synonym: "D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity" EXACT [EC:1.2.1.33] synonym: "D-aldopantoate dehydrogenase activity" EXACT [EC:1.2.1.33] xref: EC:1.2.1.33 xref: KEGG:R03198 xref: MetaCyc:R-DEHYDROPANTOATE-DEHYDROGENASE-RXN xref: RHEA:19352 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047510 name: (S)-2-methylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: S-citramalate = H(2)O + mesaconate." [EC:4.2.1.34, RHEA:13532] synonym: "(+)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.34] synonym: "(+)-citramalic hydro-lyase activity" EXACT [EC:4.2.1.34] synonym: "(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)" EXACT [EC:4.2.1.34] synonym: "(S)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.34] synonym: "citramalate dehydratase activity" EXACT [EC:4.2.1.34] synonym: "L-citramalate hydrolase activity" EXACT [EC:4.2.1.34] synonym: "mesaconase activity" EXACT [EC:4.2.1.34] synonym: "mesaconate hydratase activity" EXACT [EC:4.2.1.34] synonym: "mesaconate mesaconase activity" EXACT [EC:4.2.1.34] xref: EC:4.2.1.34 xref: KEGG:R03693 xref: MetaCyc:S-2-METHYLMALATE-DEHYDRATASE-RXN xref: RHEA:13532 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047511 name: (S)-methylmalonyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-methylmalonyl-CoA + H(2)O = CoA + H(+) + methylmalonate." [EC:3.1.2.17, RHEA:17348] synonym: "D-methylmalonyl-coenzyme A hydrolase activity" EXACT [EC:3.1.2.17] xref: EC:3.1.2.17 xref: KEGG:R02764 xref: MetaCyc:S-METHYLMALONYL-COA-HYDROLASE-RXN xref: RHEA:17348 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047512 name: (S,S)-butanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD(+) = acetoin + H(+) + NADH." [EC:1.1.1.76, RHEA:12187] synonym: "(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.76] synonym: "L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)" EXACT [EC:1.1.1.76] synonym: "L-BDH" RELATED [EC:1.1.1.76] synonym: "L-butanediol dehydrogenase activity" EXACT [EC:1.1.1.76] xref: EC:1.1.1.76 xref: KEGG:R03707 xref: MetaCyc:SS-BUTANEDIOL-DEHYDROGENASE-RXN xref: RHEA:12187 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047513 name: 1,2-alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside." [EC:3.2.1.63, MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN] synonym: "2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity" EXACT [EC:3.2.1.63] synonym: "almond emulsin fucosidase activity" EXACT [EC:3.2.1.63] synonym: "almond emulsin fucosidase II activity" NARROW [EC:3.2.1.63] synonym: "alpha-(1->2)-L-fucosidase activity" EXACT [EC:3.2.1.63] xref: EC:3.2.1.63 xref: MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN is_a: GO:0004560 ! alpha-L-fucosidase activity [Term] id: GO:0047514 name: 1,3-beta-D-glucan phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin." [EC:2.4.1.97, MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN] synonym: "1,3-beta-D-glucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.97] synonym: "1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.97] synonym: "1,3-beta-glucan phosphorylase activity" EXACT [] synonym: "laminarin phosphorylase activity" RELATED [EC:2.4.1.97] synonym: "laminarin phosphoryltransferase activity" EXACT [EC:2.4.1.97] xref: EC:2.4.1.97 xref: MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0047515 name: 1,3-beta-oligoglucan phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: oligomeric 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.30, MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN] synonym: "1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.30] synonym: "beta-1,3-oligoglucan phosphorylase activity" EXACT [EC:2.4.1.30] synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" EXACT [EC:2.4.1.30] xref: EC:2.4.1.30 xref: MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0047516 name: 1,3-propanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+." [EC:1.1.1.202, MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "1,3-PD:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202] synonym: "1,3-propanediol oxidoreductase activity" EXACT [EC:1.1.1.202] synonym: "1,3-propanediol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202] synonym: "3-hydroxypropionaldehyde reductase activity" EXACT [EC:1.1.1.202] synonym: "propane-1,3-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.202] xref: EC:1.1.1.202 xref: MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047517 name: 1,4-beta-D-xylan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-xylose + 1,4-beta-D-xylan(n) = UDP + 1,4-beta-D-xylan(n+1)." [EC:2.4.2.24, MetaCyc:1\,4-BETA-D-XYLAN-SYNTHASE-RXN] synonym: "1,4-beta-xylan synthase activity" EXACT [EC:2.4.2.24] synonym: "UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.24] synonym: "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity" EXACT [EC:2.4.2.24] synonym: "xylan synthase activity" EXACT [EC:2.4.2.24] synonym: "xylan synthetase activity" EXACT [EC:2.4.2.24] xref: EC:2.4.2.24 xref: MetaCyc:RXN-9104 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047518 name: 1-methyladenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: 1-methyladenosine + H(2)O = 1-methyladenine + ribofuranose." [EC:3.2.2.13, RHEA:12868] synonym: "1-methyladenosine hydrolase activity" EXACT [EC:3.2.2.13] synonym: "1-methyladenosine ribohydrolase activity" EXACT [EC:3.2.2.13] xref: EC:3.2.2.13 xref: KEGG:R03885 xref: MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN xref: RHEA:12868 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047519 name: quinate dehydrogenase (pyrroloquinoline-quinone) activity namespace: molecular_function def: "Catalysis of the reaction: quinate + pyrroloquinoline-quinone = 5-dehydroquinate + reduced pyrroloquinoline-quinone." [EC:1.1.99.25, MetaCyc:1.1.99.25-RXN] subset: gosubset_prok synonym: "NAD(P)-independent quinate dehydrogenase activity" EXACT [EC:1.1.99.25] synonym: "quinate:pyrroloquinoline-quinone 3-oxidoreductase activity" EXACT [EC:1.1.99.25] synonym: "quinate:pyrroloquinoline-quinone 5-oxidoreductase activity" EXACT [EC:1.1.99.25] xref: EC:1.1.99.25 xref: MetaCyc:1.1.99.25-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047520 name: 11-cis-retinyl-palmitate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 11-cis-retinyl palmitate + H(2)O = 11-cis-retinol + H(+) + palmitate." [EC:3.1.1.63, RHEA:19700] synonym: "11-cis-retinol palmitate esterase activity" EXACT [EC:3.1.1.63] synonym: "11-cis-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.63] synonym: "RPH" RELATED [EC:3.1.1.63] xref: EC:3.1.1.63 xref: KEGG:R03049 xref: MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN xref: RHEA:19700 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047521 name: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH." [EC:1.1.1.238, RHEA:21427] synonym: "12-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238] synonym: "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.238] synonym: "12beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238] synonym: "12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.238] xref: EC:1.1.1.238 xref: KEGG:R03495 xref: MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN xref: RHEA:21427 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047522 name: 15-oxoprostaglandin 13-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN] synonym: "(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity" EXACT [EC:1.3.1.48] synonym: "15-ketoprostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48] synonym: "15-oxo-delta13-prostaglandin reductase activity" EXACT [EC:1.3.1.48] synonym: "15-oxoprostaglandin 13-reductase activity" EXACT [] synonym: "delta13-15-ketoprostaglandin reductase activity" EXACT [EC:1.3.1.48] synonym: "prostaglandin 13-reductase activity" EXACT [EC:1.3.1.48] synonym: "prostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48] xref: EC:1.3.1.48 xref: MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047524 name: 16-hydroxysteroid epimerase activity namespace: molecular_function def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid." [EC:5.1.99.2, MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN] synonym: "16-hydroxysteroid 16-epimerase activity" EXACT [EC:5.1.99.2] xref: EC:5.1.99.2 xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0047525 name: 2'-hydroxydaidzein reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+." [EC:1.3.1.51, MetaCyc:2'-HYDROXYDAIDZEIN-REDUCTASE-RXN] synonym: "2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] synonym: "2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] synonym: "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] synonym: "HDR activity" EXACT [EC:1.3.1.51] synonym: "NADPH:2'-hydroxydaidzein oxidoreductase activity" EXACT [EC:1.3.1.51] xref: EC:1.3.1.51 xref: MetaCyc:RXN-4502 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047526 name: 2'-hydroxyisoflavone reductase activity namespace: molecular_function def: "Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+." [EC:1.3.1.45, MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN] subset: gosubset_prok synonym: "2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity" EXACT [EC:1.3.1.45] synonym: "isoflavone reductase activity" EXACT [EC:1.3.1.45] synonym: "NADPH:2'-hydroxyisoflavone oxidoreductase activity" EXACT [EC:1.3.1.45] synonym: "vestitone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.45] xref: EC:1.3.1.45 xref: MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047527 name: 2,3-dihydroxybenzoate-serine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine." [EC:6.3.2.14, MetaCyc:1\,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN] synonym: "2,3-dihydroxybenzoate:L-serine ligase activity" EXACT [EC:6.3.2.14] synonym: "2,3-dihydroxybenzoylserine synthetase activity" EXACT [EC:6.3.2.14] synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" EXACT [EC:6.3.2.14] xref: EC:6.3.2.14 xref: MetaCyc:23-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047528 name: 2,3-dihydroxyindole 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxyindole + O(2) = anthranilate + CO(2) + H(+)." [EC:1.13.11.23, RHEA:19448] synonym: "2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity" EXACT [EC:1.13.11.23] xref: EC:1.13.11.23 xref: KEGG:R00983 xref: MetaCyc:23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN xref: RHEA:19448 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047529 name: 2,3-dimethylmalate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate." [EC:4.1.3.32, RHEA:10475] synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)" EXACT [EC:4.1.3.32] synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32] synonym: "2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32] xref: EC:4.1.3.32 xref: KEGG:R01355 xref: MetaCyc:23-DIMETHYLMALATE-LYASE-RXN xref: RHEA:10475 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047530 name: 2,4-diaminopentanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+." [EC:1.4.1.12, MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN] synonym: "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.12] synonym: "2,4-diaminopentanoic acid C4 dehydrogenase activity" EXACT [EC:1.4.1.12] xref: EC:1.4.1.12 xref: MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0047531 name: 2,5-diaminovalerate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + ornithine = 5-amino-2-oxopentanoate + L-glutamate." [EC:2.6.1.8, RHEA:16020] synonym: "2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.8] synonym: "2,5-diaminovalerate aminotransferase activity" EXACT [] synonym: "diamino acid aminotransferase activity" EXACT [EC:2.6.1.8] synonym: "diamino-acid aminotransferase activity" RELATED [EC:2.6.1.8] synonym: "diamino-acid transaminase activity" EXACT [EC:2.6.1.8] xref: EC:2.6.1.8 xref: KEGG:R03248 xref: MetaCyc:25-DIAMINOVALERATE-AMINOTRANSFERASE-RXN xref: RHEA:16020 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047532 name: 2,5-dioxopiperazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dioxopiperazine + H(2)O = glycylglycine." [EC:3.5.2.13, RHEA:21811] synonym: "2,5-dioxopiperazine amidohydrolase activity" EXACT [EC:3.5.2.13] synonym: "cyclo(Gly-Gly) hydrolase activity" EXACT [EC:3.5.2.13] synonym: "cyclo(glycylglycine) hydrolase activity" EXACT [EC:3.5.2.13] xref: EC:3.5.2.13 xref: KEGG:R03810 xref: MetaCyc:25-DIOXOPIPERAZINE-HYDROLASE-RXN xref: RHEA:21811 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047533 name: 2,5-dioxovalerate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+." [EC:1.2.1.26, IMG:03338, MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN] synonym: "2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity" EXACT [EC:1.2.1.26] synonym: "2-oxoglutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26] synonym: "alpha-ketoglutaric semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26] xref: EC:1.2.1.26 xref: MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047534 name: 2-acetolactate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate." [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN] synonym: "2-acetolactate methylmutase activity" EXACT [EC:5.4.99.3] synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3] synonym: "acetolactate mutase activity" EXACT [EC:5.4.99.3] xref: EC:5.4.99.3 xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047535 name: 2-alkyn-1-ol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH." [EC:1.1.1.165, RHEA:19104] synonym: "2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.165] xref: EC:1.1.1.165 xref: KEGG:R03963 xref: MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN xref: RHEA:19104 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047536 name: 2-aminoadipate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12604] synonym: "2-aminoadipate aminotransferase activity" EXACT [] synonym: "2-aminoadipic aminotransferase activity" EXACT [EC:2.6.1.39] synonym: "alpha-aminoadipate aminotransferase activity" EXACT [EC:2.6.1.39] synonym: "glutamate-alpha-ketoadipate transaminase activity" EXACT [EC:2.6.1.39] synonym: "glutamic-ketoadipic transaminase activity" EXACT [EC:2.6.1.39] synonym: "L-2-aminoadipate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.39] xref: EC:2.6.1.39 xref: KEGG:R01939 xref: MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN xref: Reactome:78579 "2-aminoadipate transaminase activity" xref: RHEA:12604 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047537 name: 2-aminohexanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate." [EC:2.6.1.67, MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN] synonym: "2-aminohexanoate aminotransferase activity" EXACT [] synonym: "L-2-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "leucine L-norleucine: 2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "norleucine (leucine) aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "norleucine aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "norleucine transaminase activity" EXACT [EC:2.6.1.67] xref: EC:2.6.1.67 xref: MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047538 name: 2-carboxy-D-arabinitol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H(2)O = 2-carboxy-D-arabinitol + phosphate." [EC:3.1.3.63, RHEA:17840] synonym: "2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.63] synonym: "2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.63] synonym: "2-carboxyarabinitol 1-phosphatase activity" EXACT [EC:3.1.3.63] xref: EC:3.1.3.63 xref: KEGG:R04167 xref: MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN xref: RHEA:17840 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047539 name: 2-deoxyglucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol." [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN] synonym: "2-deoxy-alpha-D-glucosidase activity" EXACT [EC:3.2.1.112] synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" EXACT [EC:3.2.1.112] synonym: "2-deoxy-alpha-glucosidase activity" EXACT [EC:3.2.1.112] xref: EC:3.2.1.112 xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0047540 name: 2-enoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+." [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN] subset: gosubset_prok synonym: "butanoate:NAD+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.31] synonym: "enoate reductase activity" EXACT [EC:1.3.1.31] xref: EC:1.3.1.31 xref: MetaCyc:2-ENOATE-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047541 name: 2-furoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.31, RHEA:19272] synonym: "2-furoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.31] synonym: "2-furoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.31] xref: EC:6.2.1.31 xref: KEGG:R02986 xref: MetaCyc:2-FUROATE--COA-LIGASE-RXN xref: RHEA:19272 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047542 name: 2-furoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-furoyl-CoA + A + H(2)O = 5-hydroxy-2-furoyl-CoA + AH(2) + H(+)." [EC:1.3.99.8, RHEA:21483] synonym: "2-furoyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.8] synonym: "2-furoyl coenzyme A hydroxylase activity" EXACT [EC:1.3.99.8] synonym: "2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8] synonym: "2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8] synonym: "furoyl-CoA hydroxylase activity" EXACT [EC:1.3.99.8] xref: EC:1.3.99.8 xref: KEGG:R02987 xref: MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN xref: RHEA:21483 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047543 name: 2-hexadecenal reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + palmitaldehyde = trans-hexadec-2-enal + H(+) + NADPH." [EC:1.3.1.27, RHEA:12447] synonym: "hexadecanal: NADP+ oxidoreductase activity" EXACT [EC:1.3.1.27] synonym: "hexadecanal:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.27] xref: EC:1.3.1.27 xref: KEGG:R02463 xref: MetaCyc:2-HEXADECENAL-REDUCTASE-RXN xref: RHEA:12447 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047544 name: 2-hydroxybiphenyl 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+)." [EC:1.14.13.44, RHEA:11999] synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.44] xref: EC:1.14.13.44 xref: KEGG:R03964 xref: MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN xref: RHEA:11999 xref: UM-BBD_reactionID:r1423 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047545 name: 2-hydroxyglutarate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.2] synonym: "(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.2] synonym: "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)" NARROW [EC:1.1.99.2] synonym: "alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2] synonym: "alpha-hydroxyglutarate oxidoreductase activity" EXACT [EC:1.1.99.2] synonym: "alpha-ketoglutarate reductase activity" EXACT [EC:1.1.99.2] synonym: "hydroxyglutaric dehydrogenase activity" EXACT [EC:1.1.99.2] synonym: "L-alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2] synonym: "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase" NARROW [EC:1.1.99.2] xref: EC:1.1.99.2 xref: MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN xref: Reactome:78609 "2-hydroxyglutarate dehydrogenase activity" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047546 name: 2-hydroxypyridine 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O(2) = 2,5-dihydroxypyridine + A + H(2)O." [EC:1.14.99.26, RHEA:16976] synonym: "2-hydroxypyridine oxygenase activity" EXACT [EC:1.14.99.26] synonym: "2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.99.26] xref: EC:1.14.99.26 xref: KEGG:R03206 xref: MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN xref: RHEA:16976 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047547 name: 2-methylcitrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O." [EC:4.2.1.79, RHEA:17728] subset: gosubset_prok synonym: "(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.79] synonym: "2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.79] synonym: "2-methylcitrate hydro-lyase activity" EXACT [EC:4.2.1.79] synonym: "prpD" RELATED [EC:4.2.1.79] xref: EC:4.2.1.79 xref: KEGG:R04424 xref: MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN xref: RHEA:17728 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047548 name: 2-methyleneglutarate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate." [EC:5.4.99.4, RHEA:13796] subset: gosubset_prok synonym: "2-methyleneglutarate carboxy-methylenemethylmutase activity" EXACT [EC:5.4.99.4] synonym: "alpha-methyleneglutarate mutase activity" EXACT [EC:5.4.99.4] xref: EC:5.4.99.4 xref: KEGG:R03908 xref: MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN xref: RHEA:13796 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047549 name: 2-nitrophenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-nitrophenol + 2 H(+) + 2 NADPH + O(2) = catechol + H(2)O + 2 NADP(+) + nitrite." [EC:1.14.13.31, RHEA:19460] synonym: "2-nitrophenol oxygenase activity" EXACT [EC:1.14.13.31] synonym: "2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)" EXACT [EC:1.14.13.31] synonym: "nitrophenol oxygenase activity" BROAD [EC:1.14.13.31] xref: EC:1.14.13.31 xref: KEGG:R00828 xref: MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN xref: RHEA:19460 xref: UM-BBD_reactionID:r1494 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047550 name: 2-oxoadipate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH." [EC:1.1.1.172, RHEA:14796] synonym: "2-hydroxyadipate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.172] synonym: "2-ketoadipate reductase activity" EXACT [EC:1.1.1.172] synonym: "alpha-ketoadipate reductase activity" EXACT [EC:1.1.1.172] xref: EC:1.1.1.172 xref: KEGG:R01932 xref: MetaCyc:2-OXOADIPATE-REDUCTASE-RXN xref: RHEA:14796 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047551 name: 2-oxoaldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+." [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN] synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.23] synonym: "2-oxoaldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.23] synonym: "2-oxoaldehyde:NAD+ 2-oxidoreductase activity" EXACT [EC:1.2.1.23] synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.23] synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.23] synonym: "NAD-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23] synonym: "NAD-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23] xref: EC:1.2.1.23 xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN xref: Wikipedia:2-oxoaldehyde_dehydrogenase_(NAD+) is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047552 name: 2-oxoaldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+." [EC:1.2.1.49, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN] synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.49] synonym: "2-oxoaldehyde:NADP+ 2-oxidoreductase activity" EXACT [EC:1.2.1.49] synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.49] synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.49] synonym: "NADP-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49] synonym: "NADP-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49] xref: EC:1.2.1.49 xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047553 name: 2-oxoglutarate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN] subset: gosubset_prok synonym: "2-ketoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "alpha-ketoglutarate synthase activity" EXACT [EC:1.2.7.3] synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "KGOR activity" EXACT [EC:1.2.7.3] xref: EC:1.2.7.3 xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0047554 name: 2-pyrone-4,6-dicarboxylate lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H(2)O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H(+)." [EC:3.1.1.57, RHEA:10647] subset: gosubset_prok synonym: "2-pyrone-4,6-dicarboxylate lactonohydrolase activity" EXACT [EC:3.1.1.57] xref: EC:3.1.1.57 xref: KEGG:R04277 xref: MetaCyc:RXN-2462 xref: RHEA:10647 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047555 name: 3',5'-cyclic-GMP phosphodiesterase activity namespace: molecular_function alt_id: GO:0004116 def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate." [EC:3.1.4.35, MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN] synonym: "3',5' cyclic-GMP phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.35] synonym: "cGMP phosphodiesterase activity" EXACT [] synonym: "cGMP-PDE" RELATED [EC:3.1.4.35] synonym: "cGMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic 3',5'-GMP phosphodiesterase activity" EXACT [EC:3.1.4.35] synonym: "cyclic GMP phosphodiesterase activity" EXACT [] synonym: "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.35] synonym: "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.35] synonym: "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT [] xref: EC:3.1.4.35 xref: MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN xref: Reactome:78629 "3',5'-cyclic-GMP phosphodiesterase activity" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0047556 name: 3,4-dihydroxyphthalate decarboxylase activity namespace: molecular_function alt_id: GO:0034913 def: "Catalysis of the reaction: 3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO(2)." [EC:4.1.1.69, RHEA:18604] synonym: "3,4-dihydroxyphthalate 2-decarboxylase activity" EXACT [] synonym: "3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.69] synonym: "3,4-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.69] xref: EC:4.1.1.69 xref: KEGG:R01634 xref: MetaCyc:34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN xref: RHEA:18604 xref: UM-BBD_reactionID:r1447 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047557 name: 3-aci-nitropropanoate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3-aci-nitropropanoate + H(2)O + O(2) = 3-oxopropanoate + H(2)O(2) + nitrite." [EC:1.7.3.5, RHEA:22375] synonym: "3-aci-nitropropanoate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.5] synonym: "propionate-3-nitronate oxidase activity" EXACT [EC:1.7.3.5] xref: EC:1.7.3.5 xref: KEGG:R01609 xref: MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN xref: RHEA:22375 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0047558 name: 3-cyanoalanine hydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H(2)O + H(+)." [EC:4.2.1.65, RHEA:15388] synonym: "beta-CNA nitrilase activity" EXACT [EC:4.2.1.65] synonym: "beta-CNAla hydrolase activity" EXACT [EC:4.2.1.65] synonym: "beta-cyanoalanine hydratase activity" EXACT [EC:4.2.1.65] synonym: "beta-cyanoalanine hydrolase activity" EXACT [EC:4.2.1.65] synonym: "L-asparagine hydro-lyase (3-cyanoalanine-forming)" EXACT [EC:4.2.1.65] synonym: "L-asparagine hydro-lyase activity" EXACT [EC:4.2.1.65] xref: EC:4.2.1.65 xref: KEGG:R01267 xref: MetaCyc:3-CYANOALANINE-HYDRATASE-RXN xref: RHEA:15388 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047559 name: 3-dehydro-L-gulonate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+." [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN] synonym: "2,3-diketo-L-gulonate reductase activity" EXACT [EC:1.1.1.130] synonym: "3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.130] synonym: "3-keto-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.130] synonym: "3-ketogulonate dehydrogenase activity" EXACT [EC:1.1.1.130] xref: EC:1.1.1.130 xref: MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047560 name: 3-dehydrosphinganine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH." [EC:1.1.1.102, RHEA:22643] synonym: "3-ketosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "3-oxosphinganine:NADPH oxidoreductase activity" EXACT [EC:1.1.1.102] synonym: "D-3-dehydrosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "D-3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "D-3-oxosphinganine:B-NADPH oxidoreductase activity" EXACT [EC:1.1.1.102] synonym: "D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.102] synonym: "DSR activity" EXACT [EC:1.1.1.102] synonym: "KTS reductase activity" RELATED [EC:1.1.1.102] xref: EC:1.1.1.102 xref: KEGG:R02978 xref: MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN xref: Reactome:78645 "3-dehydrosphinganine reductase activity" xref: RHEA:22643 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047561 name: 3-hydroxyanthranilate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H(2)O(2)." [EC:1.10.3.5, RHEA:17248] synonym: "3-hydroxyanthranilate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.5] synonym: "3-hydroxyanthranilic acid oxidase activity" EXACT [EC:1.10.3.5] xref: EC:1.10.3.5 xref: KEGG:R02666 xref: MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN xref: RHEA:17248 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0047562 name: 3-hydroxyaspartate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate." [EC:4.1.3.14, RHEA:14380] synonym: "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14] synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)" EXACT [EC:4.1.3.14] synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14] synonym: "erythro-beta-hydroxyaspartate aldolase activity" EXACT [EC:4.1.3.14] synonym: "erythro-beta-hydroxyaspartate glycine-lyase activity" EXACT [EC:4.1.3.14] xref: EC:4.1.3.14 xref: KEGG:R00478 xref: MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN xref: RHEA:14380 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047563 name: 3-hydroxybenzoate 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O(2) = 2,3-dihydroxybenzoate + A + H(2)O." [EC:1.14.99.23, RHEA:14196] synonym: "3-HBA-2-hydroxylase activity" EXACT [EC:1.14.99.23] synonym: "3-hydroxybenzoate 2-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.23] xref: EC:1.14.99.23 xref: KEGG:R01508 xref: MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN xref: RHEA:14196 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047564 name: 3-hydroxycyclohexanone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione." [EC:1.1.99.26, RHEA:15908] synonym: "3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.26] xref: EC:1.1.99.26 xref: KEGG:R03212 xref: MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN xref: RHEA:15908 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047565 name: 3-hydroxypropionate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH." [EC:1.1.1.59, RHEA:13360] synonym: "3-hydroxypropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.59] xref: EC:1.1.1.59 xref: KEGG:R01608 xref: MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN xref: RHEA:13360 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047566 name: 3-ketovalidoxylamine C-N-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H(+)." [EC:4.3.3.1, RHEA:22771] synonym: "3-ketovalidoxylamine A C-N-lyase activity" EXACT [EC:4.3.3.1] synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]" RELATED [EC:4.3.3.1] synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity" EXACT [EC:4.3.3.1] synonym: "p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity" EXACT [EC:4.3.3.1] xref: EC:4.3.3.1 xref: KEGG:R04367 xref: MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN xref: RHEA:22771 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0047567 name: 3-methyleneoxindole reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH." [EC:1.3.1.17, RHEA:20260] synonym: "3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17] synonym: "3-methyloxindole:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17] xref: EC:1.3.1.17 xref: KEGG:R03930 xref: MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN xref: RHEA:20260 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047568 name: 3-oxo-5-beta-steroid 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor." [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN] synonym: "3-oxo-5beta-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.6] synonym: "3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.6] synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.6] synonym: "delta4-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.99.6] xref: EC:1.3.99.6 xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: GO:0047569 name: 3-oxoadipate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA." [EC:2.8.3.6, MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN] subset: gosubset_prok synonym: "3-oxoadipate coenzyme A-transferase activity" EXACT [EC:2.8.3.6] synonym: "3-oxoadipate succinyl-CoA transferase activity" EXACT [EC:2.8.3.6] synonym: "beta-ketoadipate:succinyl-CoA transferase activity" EXACT [EC:2.8.3.6] synonym: "succinyl-CoA:3-oxoadipate CoA-transferase activity" EXACT [EC:2.8.3.6] xref: EC:2.8.3.6 xref: MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN xref: UM-BBD_reactionID:r1050 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047570 name: 3-oxoadipate enol-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate." [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN] subset: gosubset_prok synonym: "3-ketoadipate enol-lactonase activity" EXACT [EC:3.1.1.24] synonym: "3-oxoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] synonym: "4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity" EXACT [EC:3.1.1.24] synonym: "beta-ketoadipate enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] synonym: "beta-ketoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] synonym: "carboxymethylbutenolide lactonase activity" EXACT [EC:3.1.1.24] xref: EC:3.1.1.24 xref: MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047571 name: 3-oxosteroid 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor." [EC:1.3.99.4, MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "1-ene-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-ketosteroid-1-en-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-ketosteroid-delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid:(acceptor) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid:acceptor delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] synonym: "4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity" EXACT [EC:1.3.99.4] synonym: "delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "delta1-steroid reductase activity" EXACT [EC:1.3.99.4] xref: EC:1.3.99.4 xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0712 is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: GO:0047572 name: 3-phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glycerate + H(2)O = D-glycerate + phosphate." [EC:3.1.3.38, RHEA:12415] synonym: "3-PGA phosphatase activity" EXACT [EC:3.1.3.38] synonym: "D-3-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.38] synonym: "D-glycerate-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.38] xref: EC:3.1.3.38 xref: KEGG:R01511 xref: MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:12415 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047573 name: 4-acetamidobutyrate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate." [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN] synonym: "4-acetamidobutanoate amidohydrolase activity" EXACT [EC:3.5.1.63] xref: EC:3.5.1.63 xref: MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047574 name: 4-acetamidobutyryl-CoA deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H(2)O = 4-aminobutanoyl-CoA + acetate." [EC:3.5.1.51, RHEA:22931] synonym: "4-acetamidobutanoyl-CoA amidohydrolase activity" EXACT [EC:3.5.1.51] synonym: "aminobutyryl-CoA thiolesterase activity" EXACT [EC:3.5.1.51] synonym: "deacetylase-thiolesterase activity" EXACT [EC:3.5.1.51] xref: EC:3.5.1.51 xref: KEGG:R04056 xref: MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN xref: RHEA:22931 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047575 name: 4-carboxymuconolactone decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = 5-oxo-4,5-dihydro-2-furylacetate + CO(2)." [EC:4.1.1.44, RHEA:23351] subset: gosubset_prok synonym: "4-carboxymonolactone carboxy-lyase activity" EXACT [EC:4.1.1.44] synonym: "4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)" EXACT [EC:4.1.1.44] synonym: "4-carboxymuconolactone carboxy-lyase activity" EXACT [EC:4.1.1.44] synonym: "gamma-4-carboxymuconolactone decarboxylase activity" EXACT [EC:4.1.1.44] xref: EC:4.1.1.44 xref: KEGG:R03470 xref: MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN xref: RHEA:23351 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047576 name: 4-chlorobenzoate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoate + H(2)O = 4-hydroxybenzoate + chloride + H(+)." [EC:3.8.1.6, RHEA:23443] synonym: "4-chlorobenzoate chlorohydrolase activity" EXACT [EC:3.8.1.6] synonym: "halobenzoate dehalogenase activity" EXACT [EC:3.8.1.6] xref: EC:3.8.1.6 xref: KEGG:R01307 xref: MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN xref: RHEA:23443 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0047577 name: 4-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde." [EC:1.1.1.61, RHEA:23951] subset: gosubset_prok synonym: "4-hydroxybutanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.61] synonym: "gamma-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.61] xref: EC:1.1.1.61 xref: KEGG:R01644 xref: MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN xref: RHEA:23951 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047578 name: 4-hydroxyglutamate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate." [EC:2.6.1.23, MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN] synonym: "4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.23] synonym: "4-hydroxyglutamate aminotransferase activity" EXACT [] xref: EC:2.6.1.23 xref: MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047579 name: 4-hydroxymandelate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-4-hydroxymandelate + H(+) + O(2) = 4-hydroxybenzaldehyde + CO(2) + H(2)O(2)." [EC:1.1.3.19, RHEA:15836] synonym: "(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.19] synonym: "L-4-hydroxymandelate oxidase (decarboxylating)" EXACT [EC:1.1.3.19] xref: EC:1.1.3.19 xref: KEGG:R02673 xref: MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN xref: RHEA:15836 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047580 name: 4-hydroxyproline epimerase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline." [EC:5.1.1.8, RHEA:21155] synonym: "4-hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8] synonym: "hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8] synonym: "hydroxyproline epimerase activity" EXACT [EC:5.1.1.8] synonym: "L-hydroxyproline epimerase activity" EXACT [EC:5.1.1.8] xref: EC:5.1.1.8 xref: KEGG:R03296 xref: MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN xref: RHEA:21155 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0047581 name: 4-methyleneglutamate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH(4)(+) = 4-methylene-L-glutamine + AMP + diphosphate + 2 H(+)." [EC:6.3.1.7, RHEA:13856] subset: gosubset_prok synonym: "4-methylene-L-glutamate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.7] synonym: "4-methyleneglutamine synthetase activity" EXACT [EC:6.3.1.7] xref: EC:6.3.1.7 xref: KEGG:R02711 xref: MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN xref: RHEA:13856 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0047582 name: 4-methyleneglutaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylene-L-glutamine + H(2)O = 4-methylene-L-glutamate + NH(4)(+)." [EC:3.5.1.67, RHEA:14744] synonym: "4-methylene-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.67] synonym: "4-methyleneglutamine amidohydrolase activity" EXACT [EC:3.5.1.67] synonym: "4-methyleneglutamine deamidase activity" EXACT [EC:3.5.1.67] xref: EC:3.5.1.67 xref: KEGG:R02712 xref: MetaCyc:4-METHYLENEGLUTAMINASE-RXN xref: RHEA:14744 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047583 name: 4-methyloxaloacetate esterase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H(2)O = H(+) + methanol + oxaloacetate." [EC:3.1.1.44, RHEA:10567] synonym: "oxaloacetate-4-methyl-ester oxaloacetohydrolase activity" EXACT [EC:3.1.1.44] xref: EC:3.1.1.44 xref: KEGG:R01144 xref: MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN xref: RHEA:10567 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047584 name: 4-oxalmesaconate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(2)O." [EC:4.2.1.83, RHEA:17404] subset: gosubset_prok synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.83] synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83] synonym: "4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83] synonym: "4-carboxy-2-oxohexenedioate hydratase activity" EXACT [EC:4.2.1.83] synonym: "gamma-oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83] synonym: "oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83] xref: EC:4.2.1.83 xref: KEGG:R04478 xref: MetaCyc:RXN-2463 xref: RHEA:17404 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047585 name: 4-pyridoxolactonase activity namespace: molecular_function def: "Catalysis of the reaction: 4-pyridoxolactone + H(2)O = 4-pyridoxate + H(+)." [EC:3.1.1.27, RHEA:14304] synonym: "4-pyridoxolactone lactonohydrolase activity" EXACT [EC:3.1.1.27] xref: EC:3.1.1.27 xref: KEGG:R02992 xref: MetaCyc:4-PYRIDOXOLACTONASE-RXN xref: RHEA:14304 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047586 name: 5'-acylphosphoadenosine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate." [EC:3.6.1.20, MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN] synonym: "5'-acylphosphoadenosine acylhydrolase activity" EXACT [EC:3.6.1.20] synonym: "5-phosphoadenosine hydrolase activity" EXACT [EC:3.6.1.20] xref: EC:3.6.1.20 xref: MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0047587 name: 5-alpha-hydroxysteroid dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H(2)O." [EC:4.2.1.62, RHEA:22067] synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)" EXACT [EC:4.2.1.62] synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity" EXACT [EC:4.2.1.62] synonym: "5alpha-hydroxysteroid dehydratase activity" EXACT [EC:4.2.1.62] xref: EC:4.2.1.62 xref: KEGG:R03675 xref: MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN xref: RHEA:22067 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047588 name: 5-aminopentanamidase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3." [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN] synonym: "5-aminonorvaleramidase activity" EXACT [EC:3.5.1.30] synonym: "5-aminopentanamide amidohydrolase activity" EXACT [EC:3.5.1.30] synonym: "5-aminovaleramidase activity" EXACT [EC:3.5.1.30] xref: EC:3.5.1.30 xref: MetaCyc:5-AMINOPENTANAMIDASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047589 name: 5-aminovalerate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate." [EC:2.6.1.48, RHEA:10215] synonym: "5-aminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.48] synonym: "5-aminovalerate aminotransferase activity" EXACT [] synonym: "delta-aminovalerate aminotransferase activity" EXACT [EC:2.6.1.48] synonym: "delta-aminovalerate transaminase activity" EXACT [EC:2.6.1.48] xref: EC:2.6.1.48 xref: KEGG:R02274 xref: MetaCyc:VAGL-RXN xref: RHEA:10215 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047590 name: 5-dehydro-2-deoxygluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate." [EC:2.7.1.92, MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN] subset: gosubset_prok synonym: "5-keto-2-deoxyglucono kinase (phosphorylating)" EXACT [EC:2.7.1.92] synonym: "5-keto-2-deoxygluconokinase activity" EXACT [EC:2.7.1.92] synonym: "ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.92] synonym: "DKH kinase activity" EXACT [EC:2.7.1.92] xref: EC:2.7.1.92 xref: MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047591 name: 5-hydroxypentanoate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate." [EC:2.8.3.14, RHEA:23499] synonym: "5-hydroxyvalerate CoA-transferase activity" EXACT [EC:2.8.3.14] synonym: "5-hydroxyvalerate coenzyme A transferase activity" EXACT [EC:2.8.3.14] synonym: "acetyl-CoA:5-hydroxypentanoate CoA-transferase activity" EXACT [EC:2.8.3.14] xref: EC:2.8.3.14 xref: KEGG:R04057 xref: MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN xref: RHEA:23499 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047592 name: 5-pyridoxate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-pyridoxate + NADPH + O(2) = (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)." [EC:1.14.12.5, RHEA:11155] synonym: "5-pyridoxate oxidase activity" EXACT [EC:1.14.12.5] synonym: "5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.5] xref: EC:1.14.12.5 xref: KEGG:R04570 xref: MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN xref: RHEA:11155 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0047593 name: 6-acetylglucose deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 6-acetyl-D-glucose + H(2)O = D-glucose + acetate + H(+)." [EC:3.1.1.33, RHEA:18488] synonym: "6-acetyl-D-glucose acetylhydrolase activity" EXACT [EC:3.1.1.33] synonym: "6-O-acetylglucose deacetylase activity" EXACT [EC:3.1.1.33] xref: EC:3.1.1.33 xref: KEGG:R00327 xref: MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN xref: RHEA:18488 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047594 name: 6-beta-hydroxyhyoscyamine epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O(2) = CO(2) + H(2)O + H(+) + scopolamine + succinate." [EC:1.14.11.14, RHEA:12800] synonym: "(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)" EXACT [EC:1.14.11.14] synonym: "6beta-hydroxyhyoscyamine epoxidase activity" EXACT [EC:1.14.11.14] synonym: "hydroxyhyoscyamine dioxygenase activity" EXACT [EC:1.14.11.14] xref: EC:1.14.11.14 xref: KEGG:R03737 xref: MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN xref: RHEA:12800 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0047595 name: 6-hydroxynicotinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin." [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN] synonym: "1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1] synonym: "6-hydroxynicotinic reductase activity" EXACT [EC:1.3.7.1] synonym: "6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1] synonym: "6-oxotetrahydro-nicotinate dehydrogenase activity" EXACT [EC:1.3.7.1] synonym: "6-oxotetrahydronicotinate dehydrogenase activity" EXACT [EC:1.3.7.1] synonym: "HNA reductase activity" EXACT [EC:1.3.7.1] xref: EC:1.3.7.1 xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0047596 name: 6-methylsalicylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 6-methylsalicylate + H(+) = 3-cresol + CO(2)." [EC:4.1.1.52, RHEA:23115] synonym: "6-methylsalicylate carboxy-lyase (3-cresol-forming)" EXACT [EC:4.1.1.52] synonym: "6-methylsalicylate carboxy-lyase activity" EXACT [EC:4.1.1.52] synonym: "6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity" EXACT [EC:4.1.1.52] synonym: "6-MSA decarboxylase activity" EXACT [EC:4.1.1.52] xref: EC:4.1.1.52 xref: KEGG:R03567 xref: MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN xref: RHEA:23115 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047597 name: 6-oxocineole dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxocineole + H(+) + NADPH + O(2) = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H(2)O + NADP(+)." [EC:1.14.13.51, RHEA:24327] synonym: "6-oxocineole oxygenase activity" EXACT [EC:1.14.13.51] synonym: "6-oxocineole,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.51] xref: EC:1.14.13.51 xref: KEGG:R02995 xref: MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN xref: RHEA:24327 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047598 name: 7-dehydrocholesterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+." [EC:1.3.1.21] synonym: "7-DHC reductase activity" EXACT [EC:1.3.1.21] synonym: "cholesterol:NADP+ delta7-oxidoreductase activity" EXACT [EC:1.3.1.21] synonym: "sterol Delta(7)-reductase activity" BROAD [EC:1.3.1.21] synonym: "sterol delta7-reductase activity" EXACT [EC:1.3.1.21] xref: EC:1.3.1.21 xref: MetaCyc:RXN66-323 xref: Reactome:78791 "7-dehydrocholesterol reductase activity" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047599 name: 8-oxocoformycin reductase activity namespace: molecular_function def: "Catalysis of the reaction: coformycin + NADP(+) = 8-oxocoformycin + 2 H(+) + NADPH." [EC:1.1.1.235, RHEA:23171] synonym: "8-ketodeoxycoformycin reductase activity" EXACT [EC:1.1.1.235] synonym: "coformycin:NADP+ 8-oxidoreductase activity" EXACT [EC:1.1.1.235] xref: EC:1.1.1.235 xref: KEGG:R03667 xref: MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN xref: RHEA:23171 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047600 name: abequosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid." [EC:2.4.1.60, MetaCyc:ABEQUOSYLTRANSFERASE-RXN] synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity" EXACT [EC:2.4.1.60] synonym: "trihexose diphospholipid abequosyltransferase activity" EXACT [EC:2.4.1.60] xref: EC:2.4.1.60 xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047601 name: acetate kinase (diphosphate) activity namespace: molecular_function def: "Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate." [EC:2.7.2.12, RHEA:24279] synonym: "acetate kinase (pyrophosphate) activity" EXACT [EC:2.7.2.12] synonym: "diphosphate:acetate phosphotransferase activity" EXACT [EC:2.7.2.12] synonym: "pyrophosphate-acetate phosphotransferase activity" EXACT [EC:2.7.2.12] xref: EC:2.7.2.12 xref: KEGG:R00320 xref: MetaCyc:ACETATE-KINASE-PYROPHOSPHATE-RXN xref: RHEA:24279 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047602 name: acetoacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + H(+) = acetone + CO(2)." [EC:4.1.1.4, RHEA:19732] subset: gosubset_prok synonym: "acetoacetate carboxy-lyase (acetone-forming)" EXACT [EC:4.1.1.4] synonym: "acetoacetate carboxy-lyase activity" EXACT [EC:4.1.1.4] synonym: "acetoacetic acid decarboxylase activity" EXACT [EC:4.1.1.4] xref: EC:4.1.1.4 xref: KEGG:R01366 xref: MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN xref: RHEA:19732 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047603 name: acetoacetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetyl-CoA + H(2)O = acetoacetate + CoA + H(+)." [EC:3.1.2.11, RHEA:15676] synonym: "acetoacetyl CoA deacylase activity" EXACT [EC:3.1.2.11] synonym: "acetoacetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.11] synonym: "acetoacetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.11] xref: EC:3.1.2.11 xref: KEGG:R01358 xref: MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN xref: RHEA:15676 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047604 name: acetoin racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-acetoin = (R)-acetoin." [EC:5.1.2.4, RHEA:12095] synonym: "acetylmethylcarbinol racemase activity" EXACT [EC:5.1.2.4] xref: EC:5.1.2.4 xref: KEGG:R02949 xref: MetaCyc:ACETOIN-RACEMASE-RXN xref: RHEA:12095 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0047605 name: acetolactate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2." [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]" RELATED [EC:4.1.1.5] synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.5] synonym: "alpha-acetolactate decarboxylase activity" EXACT [EC:4.1.1.5] xref: EC:4.1.1.5 xref: MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047606 name: hydroxynitrilase activity namespace: molecular_function alt_id: GO:0046991 def: "Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone." [EC:4.1.2, GOC:mah, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN] synonym: "(S)-acetone-cyanohydrin lyase activity" NARROW [EC:4.1.2.37] synonym: "2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)" NARROW [EC:4.1.2.37] synonym: "2-hydroxyisobutyronitrile acetone-lyase activity" NARROW [EC:4.1.2.37] synonym: "acetone-cyanhydrin lyase activity" NARROW [EC:4.1.2.37] synonym: "acetone-cyanohydrin acetone-lyase (cyanide-forming)" NARROW [EC:4.1.2.37] synonym: "acetone-cyanohydrin acetone-lyase activity" NARROW [EC:4.1.2.37] synonym: "acetone-cyanohydrin lyase activity" NARROW [EC:4..1.2.37] synonym: "alpha-hydroxynitrile lyase activity" NARROW [EC:4.1.2.37] synonym: "hydroxynitrile lyase activity" EXACT [GOC:curators] synonym: "oxynitrilase activity" RELATED [EC:4.1.2.37] xref: EC:4.1.2.37 xref: MetaCyc:4.1.2.39-RXN xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047608 name: acetylindoxyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown." [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN] synonym: "N-acetylindoxyl:oxygen oxidoreductase activity" EXACT [EC:1.7.3.2] xref: EC:1.7.3.2 xref: MetaCyc:ACETYLINDOXYL-OXIDASE-RXN is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0047609 name: acetylputrescine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylputrescine + H(2)O = acetate + putrescine." [EC:3.5.1.62, RHEA:23415] synonym: "N-acetylputrescine acetylhydrolase activity" EXACT [EC:3.5.1.62] xref: EC:3.5.1.62 xref: KEGG:R01156 xref: MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN xref: RHEA:23415 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047610 name: acetylsalicylate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: acetylsalicylate + H(2)O = acetate + H(+) + salicylate." [EC:3.1.1.55, RHEA:11755] synonym: "acetylsalicylate O-acetylhydrolase activity" EXACT [EC:3.1.1.55] synonym: "acetylsalicylic acid esterase activity" EXACT [EC:3.1.1.55] synonym: "aspirin esterase activity" EXACT [EC:3.1.1.55] synonym: "aspirin hydrolase activity" EXACT [EC:3.1.1.55] xref: EC:3.1.1.55 xref: KEGG:R02942 xref: MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN xref: RHEA:11755 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047611 name: acetylspermidine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N(8)-acetylspermidine + H(2)O = acetate + spermidine." [EC:3.5.1.48, RHEA:23931] subset: gosubset_prok synonym: "8-N-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N(1)-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N(8)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48] synonym: "N(8)-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] synonym: "N(8)-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] synonym: "N-acetylspermidine deacetylase activity" BROAD [EC:3.5.1.48] synonym: "N1-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N8-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N8-acetylspermidine deacetylase activity" EXACT [EC:3.5.1.48] synonym: "N8-monoacetylspermidine deacetylase activity" EXACT [EC:3.5.1.48] xref: EC:3.5.1.48 xref: KEGG:R07300 xref: MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN xref: RHEA:23931 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047612 name: acid-CoA ligase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H(+) + phosphate." [EC:6.2.1.10, RHEA:10971] synonym: "acid:CoA ligase (GDP-forming)" EXACT [EC:6.2.1.10] synonym: "acyl coenzyme A synthetase (guanosine diphosphate forming)" EXACT [EC:6.2.1.10] synonym: "acyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.10] xref: EC:6.2.1.10 xref: KEGG:R00394 xref: MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN xref: RHEA:10971 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047613 name: aconitate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate." [EC:4.1.1.6, RHEA:15256] synonym: "CAD activity" BROAD [EC:4.1.1.6] synonym: "cis-aconitate carboxy-lyase (itaconate-forming)" EXACT [EC:4.1.1.6] synonym: "cis-aconitate carboxy-lyase activity" EXACT [EC:4.1.1.6] synonym: "cis-aconitic decarboxylase activity" EXACT [EC:4.1.1.6] xref: EC:4.1.1.6 xref: KEGG:R02243 xref: MetaCyc:ACONITATE-DECARBOXYLASE-RXN xref: RHEA:15256 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047614 name: aconitate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: trans-aconitate = cis-aconitate." [EC:5.3.3.7, RHEA:17268] synonym: "aconitate D-isomerase activity" EXACT [] synonym: "aconitate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.7] synonym: "aconitate isomerase activity" BROAD [EC:5.3.3.7] xref: EC:5.3.3.7 xref: KEGG:R02244 xref: MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN xref: RHEA:17268 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0047615 name: actinomycin lactonase activity namespace: molecular_function def: "Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone." [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN] synonym: "actinomycin lactonohydrolase activity" EXACT [EC:3.1.1.39] xref: EC:3.1.1.39 xref: MetaCyc:ACTINOMYCIN-LACTONASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047616 name: acyl-CoA dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.8, MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN] synonym: "2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.8] synonym: "acyl-CoA:NADP+ 2-oxidoreductase activity" EXACT [EC:1.3.1.8] synonym: "crotonyl coenzyme A reductase activity" EXACT [EC:1.3.1.8] synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.8] synonym: "enoyl coenzyme A reductase activity" EXACT [EC:1.3.1.8] xref: EC:1.3.1.8 xref: MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047617 name: acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN] subset: gosubset_prok synonym: "acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.20] synonym: "acyl coenzyme A thioesterase activity" EXACT [EC:3.1.2.20] synonym: "thioesterase B" RELATED [EC:3.1.2.20] synonym: "thioesterase II" RELATED [EC:3.1.2.20] xref: EC:3.1.2.20 xref: MetaCyc:ACYL-COA-HYDROLASE-RXN is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047618 name: acylagmatine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-benzoylagmatine + H(2)O = agmatine + benzoate." [EC:3.5.1.40, RHEA:15068] synonym: "acylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40] synonym: "acylagmatine deacylase activity" EXACT [EC:3.5.1.40] synonym: "benzoylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40] xref: EC:3.5.1.40 xref: KEGG:R01425 xref: MetaCyc:ACYLAGMATINE-AMIDASE-RXN xref: RHEA:15068 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047619 name: acylcarnitine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine." [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN] synonym: "carnitine ester hydrolase activity" EXACT [EC:3.1.1.28] synonym: "HACH" RELATED [EC:3.1.1.28] synonym: "high activity acylcarnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "long-chain acyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "O-acylcarnitine acylhydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoyl carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoylcarnitine hydrolase activity" EXACT [EC:3.1.1.28] xref: EC:3.1.1.28 xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047620 name: acylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN] synonym: "ATP:acylglycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.94] synonym: "MGK" RELATED [EC:2.7.1.94] synonym: "monoacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.94] synonym: "monoacylglycerol kinase activity" EXACT [EC:2.7.1.94] synonym: "monoglyceride kinase activity" EXACT [EC:2.7.1.94] synonym: "monoglyceride phosphokinase activity" EXACT [EC:2.7.1.94] synonym: "sn-2-monoacylglycerol kinase activity" EXACT [EC:2.7.1.94] xref: EC:2.7.1.94 xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047621 name: acylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate." [EC:3.7.1.5, MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN] subset: gosubset_prok synonym: "3-acylpyruvate acylhydrolase activity" EXACT [EC:3.7.1.5] xref: EC:3.7.1.5 xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN xref: UM-BBD_reactionID:r1401 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0047622 name: adenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = D-ribose + adenine." [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN] synonym: "adenosinase activity" EXACT [EC:3.2.2.7] synonym: "adenosine hydrolase activity" EXACT [EC:3.2.2.7] synonym: "adenosine ribohydrolase activity" EXACT [EC:3.2.2.7] synonym: "ANase activity" EXACT [EC:3.2.2.7] synonym: "N-ribosyladenine ribohydrolase activity" EXACT [EC:3.2.2.7] xref: EC:3.2.2.7 xref: MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN is_a: GO:0008477 ! purine nucleosidase activity [Term] id: GO:0047623 name: adenosine-phosphate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-AMP + H2O = 5'-IMP + NH3." [EC:3.5.4.17, MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN] synonym: "adenine nucleotide deaminase activity" EXACT [EC:3.5.4.17] synonym: "adenosine (phosphate) deaminase activity" EXACT [EC:3.5.4.17] synonym: "adenosine-phosphate aminohydrolase activity" EXACT [EC:3.5.4.17] xref: EC:3.5.4.17 xref: MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047624 name: adenosine-tetraphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate." [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN] subset: gosubset_prok synonym: "adenosine-tetraphosphate phosphohydrolase activity" EXACT [EC:3.6.1.14] xref: EC:3.6.1.14 xref: MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047625 name: adenosylmethionine cyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone." [EC:2.5.1.4, RHEA:21935] synonym: "adenosyl methionine cyclotransferase activity" EXACT [] synonym: "adenosylmethioninase activity" EXACT [EC:2.5.1.4] synonym: "S-adenosyl-L-methionine alkyltransferase (cyclizing)" EXACT [EC:2.5.1.4] xref: EC:2.5.1.4 xref: KEGG:R00180 xref: MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN xref: RHEA:21935 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047626 name: adenosylmethionine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O = S-methyl-5'-thioadenosine + L-homoserine + H(+)." [EC:3.3.1.2, RHEA:14648] synonym: "adenosyl methionine hydrolase activity" EXACT [] synonym: "adenosylmethionine lyase activity" EXACT [EC:3.3.1.2] synonym: "methylmethionine-sulfonium-salt hydrolase activity" EXACT [EC:3.3.1.2] synonym: "S-adenosyl-L-methionine hydrolase activity" EXACT [EC:3.3.1.2] synonym: "S-adenosylmethionine cleaving enzyme activity" EXACT [EC:3.3.1.2] xref: EC:3.3.1.2 xref: KEGG:R00175 xref: MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN xref: RHEA:14648 is_a: GO:0016802 ! trialkylsulfonium hydrolase activity [Term] id: GO:0047627 name: adenylylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-adenylyl sulfate + H(2)O = AMP + 2 H(+) + sulfate." [EC:3.6.2.1, RHEA:17044] synonym: "adenosine 5-phosphosulfate sulfohydrolase activity" EXACT [EC:3.6.2.1] synonym: "adenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.1] synonym: "adenylylsulphatase activity" EXACT [] xref: EC:3.6.2.1 xref: KEGG:R00531 xref: MetaCyc:ADENYLYLSULFATASE-RXN xref: RHEA:17044 is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides [Term] id: GO:0047628 name: ADP-thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate." [EC:2.7.1.118, MetaCyc:ADP--THYMIDINE-KINASE-RXN] synonym: "adenosine diphosphate-thymidine phosphotransferase activity" EXACT [EC:2.7.1.118] synonym: "ADP:dThd phosphotransferase activity" EXACT [EC:2.7.1.118] synonym: "ADP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.118] xref: EC:2.7.1.118 xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047629 name: ADP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + H2O = IDP + NH3." [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN] synonym: "adenosine diphosphate deaminase activity" EXACT [EC:3.5.4.7] synonym: "adenosinepyrophosphate deaminase activity" EXACT [EC:3.5.4.7] synonym: "ADP aminohydrolase activity" EXACT [EC:3.5.4.7] xref: EC:3.5.4.7 xref: MetaCyc:ADP-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047630 name: ADP-phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H(2)O = 3-ADP-glycerate + phosphate." [EC:3.1.3.28, RHEA:15864] synonym: "3-(ADP)-2-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.28] synonym: "adenosine diphosphate phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28] synonym: "ADPphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28] xref: EC:3.1.3.28 xref: KEGG:R03969 xref: MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:15864 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047631 name: ADP-ribose diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN] subset: gosubset_prok synonym: "adenosine diphosphoribose pyrophosphatase activity" EXACT [] synonym: "ADP-ribose phosphohydrolase activity" EXACT [] synonym: "ADP-ribose pyrophosphatase activity" EXACT [] synonym: "ADP-ribose ribophosphohydrolase activity" EXACT [EC:3.6.1.13] synonym: "ADPR-PPase activity" EXACT [] synonym: "ADPribose diphosphatase activity" EXACT [EC:3.6.1.13] synonym: "ADPribose pyrophosphatase activity" EXACT [EC:3.6.1.13] xref: EC:3.6.1.13 xref: MetaCyc:RXN0-1441 is_a: GO:0019144 ! ADP-sugar diphosphatase activity [Term] id: GO:0047632 name: agmatine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN] subset: gosubset_prok synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.12] synonym: "agmatine iminohydrolase activity" EXACT [EC:3.5.3.12] xref: EC:3.5.3.12 xref: MetaCyc:AGMATINE-DEIMINASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047633 name: agmatine kinase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H(+)." [EC:2.7.3.10, RHEA:15956] synonym: "ATP:agmatine 4-N-phosphotransferase activity" EXACT [EC:2.7.3.10] synonym: "ATP:agmatine N4-phosphotransferase activity" EXACT [EC:2.7.3.10] synonym: "phosphagen phosphokinase activity" RELATED [EC:2.7.3.10] xref: EC:2.7.3.10 xref: KEGG:R01417 xref: MetaCyc:AGMATINE-KINASE-RXN xref: RHEA:15956 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0047634 name: agmatine N4-coumaroyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H(+)." [EC:2.3.1.64, RHEA:13408] synonym: "4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity" EXACT [EC:2.3.1.64] synonym: "4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity" EXACT [EC:2.3.1.64] synonym: "agmatine coumaroyltransferase activity" EXACT [EC:2.3.1.64] synonym: "p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity" EXACT [EC:2.3.1.64] xref: EC:2.3.1.64 xref: KEGG:R01617 xref: MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN xref: RHEA:13408 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047635 name: alanine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid." [EC:2.6.1.12, MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN] subset: gosubset_prok synonym: "alanine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "alanine-keto acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "alanine-oxo acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "alanine-oxo-acid aminotransferase activity" EXACT [] synonym: "L-alanine-alpha-keto acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "L-alanine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "leucine-alanine transaminase activity" EXACT [EC:2.6.1.12] xref: EC:2.6.1.12 xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047636 name: alanopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,2'-iminodipropanoate + H(2)O + NAD(+) = L-alanine + H(+) + NADH + pyruvate." [EC:1.5.1.17, RHEA:17592] synonym: "2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)" EXACT [EC:1.5.1.17] synonym: "ADH" RELATED [EC:1.5.1.17] synonym: "alanopine: NAD oxidoreductase activity" EXACT [EC:1.5.1.17] synonym: "alanopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.17] synonym: "alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity" EXACT [EC:1.5.1.17] synonym: "ALPDH" RELATED [EC:1.5.1.17] synonym: "meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.17] xref: EC:1.5.1.17 xref: KEGG:R00398 xref: MetaCyc:ALANOPINE-DEHYDROGENASE-RXN xref: RHEA:17592 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047637 name: alanylphosphatidylglycerol synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol." [EC:2.3.2.11, MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN] synonym: "alanyl phosphatidylglycerol synthetase activity" EXACT [EC:2.3.2.11] synonym: "L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity" EXACT [EC:2.3.2.11] synonym: "O-alanylphosphatidylglycerol synthase activity" EXACT [EC:2.3.2.11] xref: EC:2.3.2.11 xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047638 name: albendazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+)." [EC:1.14.13.32, RHEA:10799] synonym: "albendazole oxidase activity" EXACT [EC:1.14.13.32] synonym: "albendazole sulfoxidase activity" EXACT [EC:1.14.13.32] synonym: "albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)" EXACT [EC:1.14.13.32] xref: EC:1.14.13.32 xref: KEGG:R03712 xref: MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN xref: RHEA:10799 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047639 name: alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2." [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN] comment: Note that the enzyme alcohol oxidase also has methanol oxidase activity (GO:0046563). synonym: "alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.13] synonym: "AOX activity" EXACT [EC:1.1.3.13] synonym: "ethanol oxidase activity" EXACT [EC:1.1.3.13] xref: EC:1.1.3.13 xref: MetaCyc:ALCOHOL-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047640 name: aldose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH." [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN] synonym: "aldose dehydrogenase activity" EXACT [EC:1.1.1.121] synonym: "D-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.121] synonym: "dehydrogenase, D-aldohexose" EXACT [EC:1.1.1.121] xref: EC:1.1.1.121 xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047641 name: aldose-6-phosphate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: D-glucitol 6-phosphate + NADP(+) = D-glucose 6-phosphate + H(+) + NADPH." [EC:1.1.1.200, RHEA:20040] synonym: "A6PR" RELATED [EC:1.1.1.200] synonym: "alditol 6-phosphate:NADP 1-oxidoreductase activity" EXACT [EC:1.1.1.200] synonym: "aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200] synonym: "aldose-6-P reductase activity" EXACT [EC:1.1.1.200] synonym: "aldose-6-phosphate reductase activity" EXACT [EC:1.1.1.200] synonym: "D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.200] synonym: "NADP-dependent aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200] synonym: "NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.200] xref: EC:1.1.1.200 xref: KEGG:R00834 xref: MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-NADPH-RXN xref: RHEA:20040 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047642 name: aldose beta-D-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside." [EC:2.4.1.162, MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN] synonym: "aldose b-D-fructosyltransferase activity" EXACT [] synonym: "alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.162] xref: EC:2.4.1.162 xref: MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN is_a: GO:0050738 ! fructosyltransferase activity [Term] id: GO:0047643 name: alginate synthase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)." [EC:2.4.1.33, MetaCyc:ALGINATE-SYNTHASE-RXN] synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" EXACT [EC:2.4.1.33] synonym: "mannuronosyl transferase activity" EXACT [EC:2.4.1.33] xref: EC:2.4.1.33 xref: MetaCyc:ALGINATE-SYNTHASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047644 name: alizarin 2-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP." [EC:2.4.1.103, RHEA:20680] synonym: "alizarin 2-b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.103] synonym: "UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity" EXACT [EC:2.4.1.103] synonym: "uridine diphosphoglucose-alizarin glucosyltransferase activity" EXACT [EC:2.4.1.103] xref: EC:2.4.1.103 xref: KEGG:R03573 xref: MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:20680 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047645 name: alkan-1-ol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor." [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN] synonym: "alkan-1-ol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.20] synonym: "alkan-1-ol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.20] synonym: "polyethylene glycol dehydrogenase activity" NARROW [EC:1.1.99.20] xref: EC:1.1.99.20 xref: MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047646 name: alkanal monooxygenase (FMN-linked) activity namespace: molecular_function def: "Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light." [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN] subset: gosubset_prok synonym: "aldehyde monooxygenase activity" BROAD [EC:1.14.14.3] synonym: "alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)" EXACT [EC:1.14.14.3] synonym: "bacterial luciferase activity" EXACT [EC:1.14.14.3] synonym: "vibrio fischeri luciferase activity" EXACT [EC:1.14.14.3] xref: EC:1.14.14.3 xref: MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047647 name: alkylacetylglycerophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H(2)O = 2-acetyl-1-alkyl-sn-glycerol + phosphate." [EC:3.1.3.59, RHEA:18224] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.59] synonym: "1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity" EXACT [EC:3.1.3.59] synonym: "alkylacetylglycerophosphate phosphatase activity" EXACT [EC:3.1.3.59] xref: EC:3.1.3.59 xref: KEGG:R03454 xref: MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN xref: RHEA:18224 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047648 name: alkylamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylhexanamide + H(2)O = hexanoate + methylammonium." [EC:3.5.1.39, RHEA:20084] synonym: "N-methylhexanamide amidohydrolase activity" EXACT [EC:3.5.1.39] xref: EC:3.5.1.39 xref: KEGG:R03620 xref: MetaCyc:ALKYLAMIDASE-RXN xref: RHEA:20084 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047649 name: alkylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.93, RHEA:16940] synonym: "1-alkylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.93] synonym: "alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93] synonym: "ATP-alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93] synonym: "ATP:1-alkyl-sn-glycerol phosphotransferase activity" EXACT [EC:2.7.1.93] synonym: "ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.93] xref: EC:2.7.1.93 xref: KEGG:R04126 xref: MetaCyc:ALKYLGLYCEROL-KINASE-RXN xref: RHEA:16940 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047650 name: alkylglycerone kinase activity namespace: molecular_function def: "Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H(+)." [EC:2.7.1.84, RHEA:23091] synonym: "alkyldihydroxyacetone kinase (phosphorylating)" EXACT [EC:2.7.1.84] synonym: "alkyldihydroxyacetone kinase activity" EXACT [EC:2.7.1.84] synonym: "ATP:O-alkylglycerone phosphotransferase activity" EXACT [EC:2.7.1.84] xref: EC:2.7.1.84 xref: KEGG:R03944 xref: MetaCyc:ALKYLGLYCERONE-KINASE-RXN xref: RHEA:23091 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047651 name: alkylhalidase activity namespace: molecular_function def: "Catalysis of the reaction: bromochloromethane + H(2)O = bromide + chloride + formaldehyde + 2 H(+)." [EC:3.8.1.1, RHEA:13768] subset: gosubset_prok synonym: "alkyl-halide halidohydrolase activity" EXACT [EC:3.8.1.1] synonym: "haloalkane halidohydrolase activity" EXACT [EC:3.8.1.1] synonym: "halogenase activity" RELATED [EC:3.8.1.1] xref: EC:3.8.1.1 xref: KEGG:R03523 xref: MetaCyc:ALKYLHALIDASE-RXN xref: RHEA:13768 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0047652 name: allantoate deiminase activity namespace: molecular_function def: "Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine." [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN] synonym: "allantoate amidinohydrolase (decarboxylating)" EXACT [EC:3.5.3.9] synonym: "allantoate amidohydrolase activity" EXACT [EC:3.5.3.9] xref: EC:3.5.3.9 xref: MetaCyc:ALLANTOATE-DEIMINASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047653 name: allantoin racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin." [EC:5.1.99.3, RHEA:10807] xref: EC:5.1.99.3 xref: KEGG:R03925 xref: MetaCyc:ALLANTOIN-RACEMASE-RXN xref: RHEA:10807 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0047654 name: alliin lyase activity namespace: molecular_function def: "Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate." [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN] synonym: "alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "alliin alkyl-sulfenate-lyase activity" EXACT [EC:4.4.1.4] synonym: "alliinase activity" EXACT [EC:4.4.1.4] synonym: "cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "cysteine sulphoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)" EXACT [EC:4.4.1.4] synonym: "S-alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] xref: EC:4.4.1.4 xref: MetaCyc:ALLIIN-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047655 name: allyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH." [EC:1.1.1.54, RHEA:12171] synonym: "allyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.54] xref: EC:1.1.1.54 xref: KEGG:R03572 xref: MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN xref: RHEA:12171 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047656 name: alpha,alpha-trehalose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.64, MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN] subset: gosubset_prok synonym: "a,a-trehalose phosphorylase activity" EXACT [] synonym: "alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.64] synonym: "trehalose phosphorylase" BROAD [EC:2.4.1.64] xref: EC:2.4.1.64 xref: MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0047657 name: alpha-1,3-glucan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1." [EC:2.4.1.183, MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN] synonym: "1,3-alpha-D-glucan synthase activity" EXACT [EC:2.4.1.183] synonym: "1,3-alpha-glucan synthase activity" EXACT [] synonym: "a-1,3-glucan synthase activity" EXACT [] synonym: "UDP-glucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183] synonym: "UDPglucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183] synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.183] xref: EC:2.4.1.183 xref: MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047658 name: alpha-amino-acid esterase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol." [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN] subset: gosubset_prok synonym: "a-amino-acid esterase activity" EXACT [] synonym: "alpha-amino acid ester hydrolase activity" EXACT [EC:3.1.1.43] synonym: "alpha-amino-acid ester hydrolase activity" EXACT [EC:3.1.1.43] synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" EXACT [EC:3.1.1.43] xref: EC:3.1.1.43 xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047659 name: alpha-santonin 1,2-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+." [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN] synonym: "1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.47] synonym: "a-santonin 1,2-reductase activity" EXACT [] xref: EC:1.3.1.47 xref: MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047660 name: amidinoaspartase activity namespace: molecular_function def: "Catalysis of the reaction: N-amidino-L-aspartate + H(2)O = L-aspartate + urea." [EC:3.5.3.14, RHEA:14852] synonym: "amidinoaspartic amidinohydrolase activity" EXACT [EC:3.5.3.14] synonym: "N-amidino-L-aspartate amidinohydrolase activity" EXACT [EC:3.5.3.14] xref: EC:3.5.3.14 xref: KEGG:R00777 xref: MetaCyc:AMIDINOASPARTASE-RXN xref: RHEA:14852 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047661 name: amino-acid racemase activity namespace: molecular_function def: "Catalysis of the reaction: an L-amino acid = a D-amino acid." [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN] subset: gosubset_prok synonym: "L-amino acid racemase activity" EXACT [EC:5.1.1.10] xref: EC:5.1.1.10 xref: MetaCyc:AMINO-ACID-RACEMASE-RXN is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0047662 name: aminobenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2." [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN] synonym: "aminobenzoate carboxy-lyase (aniline-forming)" EXACT [EC:4.1.1.24] synonym: "aminobenzoate carboxy-lyase activity" EXACT [EC:4.1.1.24] xref: EC:4.1.1.24 xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047663 name: aminoglycoside 6'-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H(+). This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.82, RHEA:16452] subset: gosubset_prok synonym: "6'-aminoglycoside-N-acetyltransferase activity" EXACT [EC:2.3.1.82] synonym: "AAC(6') activity" RELATED [EC:2.3.1.82] synonym: "acetyl-CoA:kanamycin-B N6'-acetyltransferase activity" NARROW [EC:2.3.1.82] synonym: "aminoglycoside N6'-acetyltransferase activity" EXACT [] synonym: "aminoglycoside-6'-acetyltransferase activity" EXACT [EC:2.3.1.82] synonym: "aminoglycoside-6-N-acetyltransferase activity" EXACT [EC:2.3.1.82] synonym: "kanamycin 6'-N-acetyltransferase activity" NARROW [] xref: EC:2.3.1.82 xref: KEGG:R01889 xref: MetaCyc:AMINOGLYCOSIDE-N6-ACETYLTRANSFERASE-RXN xref: RHEA:16452 is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity [Term] id: GO:0047664 name: aminoimidazolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminoimidazole + H2O = unidentified product + NH3." [EC:3.5.4.8, MetaCyc:AMINOIMIDAZOLASE-RXN] synonym: "4-aminoimidazole aminohydrolase activity" EXACT [EC:3.5.4.8] synonym: "4-aminoimidazole hydrolase activity" EXACT [EC:3.5.4.8] xref: EC:3.5.4.8 xref: MetaCyc:R13-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0047665 name: aminolevulinate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine." [EC:2.6.1.43, RHEA:12483] synonym: "4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "4,5-dioxovaleric acid aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "4,5-dioxovaleric transaminase activity" EXACT [EC:2.6.1.43] synonym: "5-aminolevulinate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "5-aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "alanine-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "alanine-gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "alanine:4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "aminolevulinate aminotransferase activity" EXACT [] synonym: "aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "dioxovalerate transaminase activity" EXACT [EC:2.6.1.43] synonym: "DOVA transaminase activity" EXACT [EC:2.6.1.43] synonym: "gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "gamma,delta-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "L-alanine-4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "L-alanine:4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "L-alanine:dioxovalerate transaminase activity" EXACT [EC:2.6.1.43] xref: EC:2.6.1.43 xref: KEGG:R02271 xref: MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN xref: RHEA:12483 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047666 name: ammonia kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NH(4)(+) = ADP + 3 H(+) + phosphoramidate." [EC:2.7.3.8, RHEA:11027] synonym: "ATP:ammonia phosphotransferase activity" EXACT [EC:2.7.3.8] synonym: "phosphoramidate-adenosine diphosphate phosphotransferase activity" EXACT [EC:2.7.3.8] synonym: "phosphoramidate-ADP-phosphotransferase activity" EXACT [EC:2.7.3.8] xref: EC:2.7.3.8 xref: KEGG:R00141 xref: MetaCyc:AMMONIA-KINASE-RXN xref: RHEA:11027 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0047667 name: AMP-thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate." [EC:2.7.1.114, MetaCyc:AMP--THYMIDINE-KINASE-RXN] synonym: "adenylate-nucleoside phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "adenylic acid:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "AMP:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "AMP:deoxythymidine kinase activity" EXACT [EC:2.7.1.114] synonym: "AMP:dThd kinase activity" EXACT [EC:2.7.1.114] synonym: "AMP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "thymidine phosphotransferase activity" EXACT [EC:2.7.1.114] xref: EC:2.7.1.114 xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047668 name: amygdalin beta-glucosidase activity namespace: molecular_function alt_id: GO:0080080 def: "Catalysis of the reaction: (R)-amygdalin + H(2)O = (R)-prunasin + D-glucose." [EC:3.2.1.117, RHEA:14180] synonym: "(R)-amygdalin beta-glucosidase activity" EXACT [] synonym: "amygdalin b-glucosidase activity" EXACT [] synonym: "amygdalin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.117] synonym: "amygdalin glucosidase activity" EXACT [EC:3.2.1.117] synonym: "amygdalin hydrolase activity" EXACT [EC:3.2.1.117] synonym: "amygdalinase" BROAD [EC:3.2.1.117] xref: EC:3.2.1.117 xref: KEGG:R02985 xref: MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN xref: RHEA:14180 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0047669 name: amylosucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)." [EC:2.4.1.4, MetaCyc:AMYLOSUCRASE-RXN] subset: gosubset_prok synonym: "sucrose-1,4-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4] synonym: "sucrose-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4] synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.4] xref: EC:2.4.1.4 xref: MetaCyc:AMYLOSUCRASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047670 name: anhydrotetracycline monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: anhydrotetracycline + H(+) + NADPH + O(2) = 12-dehydrotetracycline + H(2)O + NADP(+)." [EC:1.14.13.38, RHEA:11979] synonym: "anhydrotetracycline oxygenase activity" EXACT [EC:1.14.13.38] synonym: "anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.38] synonym: "ATC oxygenase activity" EXACT [EC:1.14.13.38] xref: EC:1.14.13.38 xref: KEGG:R04060 xref: MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN xref: RHEA:11979 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047671 name: anthranilate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + ATP = N-adenylylanthranilate + diphosphate + H(+)." [EC:2.7.7.55, RHEA:22415] synonym: "anthranilic acid adenylyltransferase activity" EXACT [EC:2.7.7.55] synonym: "ATP:anthranilate adenylyltransferase activity" EXACT [] synonym: "ATP:anthranilate N-adenylyltransferase activity" EXACT [EC:2.7.7.55] xref: EC:2.7.7.55 xref: KEGG:R00979 xref: MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN xref: RHEA:22415 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0047672 name: anthranilate N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA." [EC:2.3.1.144, RHEA:21603] synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.3.1.144] xref: EC:2.3.1.144 xref: KEGG:R02453 xref: MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN xref: RHEA:21603 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047673 name: anthranilate N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA." [EC:2.3.1.113, RHEA:17560] synonym: "malonyl-CoA:anthranilate N-malonyltransferase activity" EXACT [EC:2.3.1.113] xref: EC:2.3.1.113 xref: KEGG:R00989 xref: MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN xref: RHEA:17560 is_a: GO:0050735 ! N-malonyltransferase activity [Term] id: GO:0047674 name: apiose 1-reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-apiitol + NAD(+) = D-apiose + H(+) + NADH." [EC:1.1.1.114, RHEA:15304] synonym: "D-apiitol reductase activity" EXACT [EC:1.1.1.114] synonym: "D-apiitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.114] synonym: "D-apiose reductase activity" EXACT [EC:1.1.1.114] xref: EC:1.1.1.114 xref: KEGG:R03577 xref: MetaCyc:APIOSE-1-REDUCTASE-RXN xref: RHEA:15304 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047675 name: arabinonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O." [EC:4.2.1.5, RHEA:21839] synonym: "D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)" EXACT [EC:4.2.1.5] synonym: "D-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.5] xref: EC:4.2.1.5 xref: KEGG:R03032 xref: MetaCyc:ARABINONATE-DEHYDRATASE-RXN xref: RHEA:21839 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047676 name: arachidonate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+)." [EC:6.2.1.15, RHEA:19716] synonym: "arachidonate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.15] synonym: "arachidonoyl-CoA synthetase activity" EXACT [EC:6.2.1.15] xref: EC:6.2.1.15 xref: KEGG:R01598 xref: MetaCyc:ARACHIDONATE--COA-LIGASE-RXN xref: RHEA:19716 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047677 name: arachidonate 8-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.40, RHEA:14988] synonym: "8(R)-lipoxygenase activity" EXACT [EC:1.13.11.40] synonym: "8-lipoxygenase activity" NARROW [EC:1.13.11.40] synonym: "arachidonate:oxygen 8-oxidoreductase activity" EXACT [EC:1.13.11.40] xref: EC:1.13.11.40 xref: KEGG:R01594 xref: MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN xref: RHEA:14988 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047678 name: arginine 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + O(2) = 4-guanidinobutanamide + CO(2) + H(2)O." [EC:1.13.12.1, RHEA:10551] synonym: "arginine decarboxy-oxidase activity" EXACT [EC:1.13.12.1] synonym: "arginine monooxygenase activity" EXACT [EC:1.13.12.1] synonym: "arginine oxygenase (decarboxylating) activity" EXACT [EC:1.13.12.1] synonym: "L-arginine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.1] xref: EC:1.13.12.1 xref: KEGG:R00559 xref: MetaCyc:ARGININE-2-MONOOXYGENASE-RXN xref: RHEA:10551 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0047679 name: arginine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine = D-arginine." [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN] xref: EC:5.1.1.9 xref: MetaCyc:ARGININE-RACEMASE-RXN is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0047680 name: aryl-acylamidase activity namespace: molecular_function def: "Catalysis of the reaction: anilide + H(2)O = a carboxylate + aniline + H(+)." [EC:3.5.1.13, RHEA:20300] subset: gosubset_prok synonym: "AAA-1" RELATED [EC:3.5.1.13] synonym: "AAA-2" RELATED [EC:3.5.1.13] synonym: "aryl-acylamide amidohydrolase activity" EXACT [EC:3.5.1.13] synonym: "brain acetylcholinesterase (is associated with AAA-2)" EXACT [EC:3.5.1.13] synonym: "pseudocholinesterase (associated with arylacylamidase)" EXACT [EC:3.5.1.13] xref: EC:3.5.1.13 xref: KEGG:R01862 xref: MetaCyc:ARYL-ACYLAMIDASE-RXN xref: RHEA:20300 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047681 name: aryl-alcohol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH." [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN] synonym: "aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.91] synonym: "aryl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.91] synonym: "NADPH-linked benzaldehyde reductase activity" EXACT [EC:1.1.1.91] xref: EC:1.1.1.91 xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047682 name: aryl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2." [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN] synonym: "arom. alcohol oxidase activity" EXACT [EC:1.1.3.7] synonym: "aryl alcohol oxidase activity" EXACT [EC:1.1.3.7] synonym: "aryl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.7] synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7] xref: EC:1.1.3.7 xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047683 name: aryl-aldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP." [EC:1.2.1.30, MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN] synonym: "aromatic acid reductase activity" EXACT [EC:1.2.1.30] synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" EXACT [EC:1.2.1.30] xref: EC:1.2.1.30 xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047684 name: arylamine glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine." [EC:2.4.1.71, MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP glucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71] synonym: "UDP-glucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71] synonym: "UDPglucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71] synonym: "uridine diphosphoglucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71] xref: EC:2.4.1.71 xref: MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047685 name: amine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate." [EC:2.8.2.3, MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity" EXACT [EC:2.8.2.3] synonym: "amine N-sulfotransferase activity" EXACT [EC:2.8.2.3] synonym: "amine sulphotransferase activity" EXACT [] synonym: "arylamine sulfotransferase activity" EXACT [] xref: EC:2.8.2.3 xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047686 name: arylsulfate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate." [EC:2.8.2.22, MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN] subset: gosubset_prok synonym: "arylsulfate-phenol sulfotransferase activity" EXACT [EC:2.8.2.22] synonym: "arylsulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.22] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.22] synonym: "arylsulphate sulphotransferase activity" EXACT [] synonym: "ASST" RELATED [EC:2.8.2.22] xref: EC:2.8.2.22 xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047687 name: ascorbate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate + H(2)O + O(2) = L-threonate + 2 H(+) + oxalate." [EC:1.13.11.13, RHEA:21787] synonym: "AAoxygenase activity" EXACT [EC:1.13.11.13] synonym: "ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving)" EXACT [EC:1.13.11.13] xref: EC:1.13.11.13 xref: KEGG:R00646 xref: MetaCyc:ASCORBATE-23-DIOXYGENASE-RXN xref: RHEA:21787 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047688 name: aspartate 4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = L-alanine + CO2." [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "aminomalonic decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartate omega-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartic beta-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartic omega-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "cysteine sulfinic desulfinase activity" EXACT [EC:4.1.1.12] synonym: "desulfinase activity" EXACT [EC:4.1.1.12] synonym: "L-aspartate 4-carboxy-lyase (L-alanine-forming)" EXACT [EC:4.1.1.12] synonym: "L-aspartate 4-carboxy-lyase activity" EXACT [EC:4.1.1.12] synonym: "L-aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "L-cysteine sulfinate acid desulfinase activity" EXACT [EC:4.1.1.12] xref: EC:4.1.1.12 xref: MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047689 name: aspartate racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = D-aspartate." [EC:5.1.1.13, RHEA:14976] subset: gosubset_prok synonym: "D-aspartate racemase activity" EXACT [EC:5.1.1.13] xref: EC:5.1.1.13 xref: KEGG:R00491 xref: MetaCyc:ASPARTATE-RACEMASE-RXN xref: RHEA:14976 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0047690 name: aspartyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + H(+) + hydroxylamine = beta-L-aspartylhydroxamate + NH(4)(+)." [EC:2.3.2.7, RHEA:11255] synonym: "aspartotransferase activity" EXACT [EC:2.3.2.7] synonym: "beta-aspartyl transferase activity" EXACT [EC:2.3.2.7] synonym: "L-asparagine:hydroxylamine gamma-aspartyltransferase activity" EXACT [EC:2.3.2.7] xref: EC:2.3.2.7 xref: KEGG:R01485 xref: MetaCyc:ASPARTYLTRANSFERASE-RXN xref: RHEA:11255 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047691 name: aspulvinone dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate." [EC:2.5.1.35, RHEA:13812] synonym: "dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity" EXACT [EC:2.5.1.35] synonym: "dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity" EXACT [EC:2.5.1.35] xref: EC:2.5.1.35 xref: KEGG:R03799 xref: MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN xref: RHEA:13812 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047692 name: ATP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ITP + NH3." [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN] synonym: "adenosine triphosphate deaminase activity" EXACT [EC:3.5.4.18] synonym: "ATP aminohydrolase activity" EXACT [EC:3.5.4.18] xref: EC:3.5.4.18 xref: MetaCyc:ATP-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047693 name: ATP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = AMP + diphosphate." [EC:3.6.1.8, MetaCyc:ATP-PYROPHOSPHATASE-RXN] subset: gosubset_prok synonym: "adenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.8] synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.8] synonym: "ATP diphosphohydrolase (diphosphate-forming)" EXACT [EC:3.6.1.8] synonym: "ATP pyrophosphatase activity" EXACT [] xref: EC:3.6.1.8 xref: MetaCyc:ATP-PYROPHOSPHATASE-RXN is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0047694 name: barbiturase activity namespace: molecular_function def: "Catalysis of the reaction: barbiturate + H2O = malonate + urea." [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN] synonym: "barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)" EXACT [EC:3.5.2.1] xref: EC:3.5.2.1 xref: MetaCyc:BARBITURASE-RXN is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047695 name: benzoin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: benzoin = 2 benzaldehyde." [EC:4.1.2.38, RHEA:21463] subset: gosubset_prok synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity" EXACT [EC:4.1.2.38] synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)" EXACT [EC:4.1.2.38] synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38] synonym: "benzaldehyde lyase activity" EXACT [EC:4.1.2.38] synonym: "diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38] xref: EC:4.1.2.38 xref: KEGG:R00027 xref: MetaCyc:BENZOIN-ALDOLASE-RXN xref: RHEA:21463 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047696 name: beta-adrenergic receptor kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor." [EC:2.7.11.15, MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN] synonym: "[b-adrenergic-receptor] kinase activity" EXACT [EC:2.7.11.15] synonym: "ADRBK1" RELATED [EC:2.7.11.15] synonym: "adrenergic receptor kinase activity" BROAD [EC:2.7.11.15] synonym: "ATP:beta-adrenergic-receptor phosphotransferase activity" BROAD [EC:2.7.11.15] synonym: "BARK1" RELATED [EC:2.7.11.15] synonym: "beta-adrenergic receptor-specific kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-adrenergic-receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.15] synonym: "beta-adrenergic-receptor kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-adrenoceptor kinase 1 activity" NARROW [EC:2.7.11.15] synonym: "beta-adrenoceptor kinase 2 activity" NARROW [EC:2.7.11.15] synonym: "beta-adrenoceptor kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-AR kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-ARK" RELATED [EC:2.7.11.15] synonym: "beta-ARK 1" RELATED [EC:2.7.11.15] synonym: "beta-ARK 2" RELATED [EC:2.7.11.15] synonym: "beta-receptor kinase activity" EXACT [EC:2.7.11.15] synonym: "beta2ARK" RELATED [EC:2.7.11.15] synonym: "betaARK1" RELATED [EC:2.7.11.15] synonym: "GRK2" RELATED [EC:2.7.11.15] synonym: "GRK3" RELATED [EC:2.7.11.15] synonym: "STK15" RELATED [EC:2.7.11.15] xref: EC:2.7.11.15 is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0047697 name: beta-alanopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-beta-alanopine + H(2)O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate." [EC:1.5.1.26, RHEA:21687] synonym: "b-alanopine dehydrogenase activity" EXACT [] synonym: "N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)" EXACT [EC:1.5.1.26] xref: EC:1.5.1.26 xref: KEGG:R00906 xref: MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN xref: RHEA:21687 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047698 name: beta-alanyl-CoA ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3." [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN] synonym: "b-alanyl-CoA ammonia-lyase activity" EXACT [] synonym: "beta-alanyl coenzyme A ammonia-lyase activity" EXACT [EC:4.3.1.6] synonym: "beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)" EXACT [EC:4.3.1.6] xref: EC:4.3.1.6 xref: MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047699 name: beta-diketone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one." [EC:3.7.1.7, RHEA:11911] synonym: "b-diketone hydrolase activity" EXACT [] synonym: "nonane-4,6-dione acylhydrolase activity" EXACT [EC:3.7.1.7] synonym: "oxidized PVA hydrolase activity" EXACT [EC:3.7.1.7] xref: EC:3.7.1.7 xref: KEGG:R03781 xref: MetaCyc:BETA-DIKETONE-HYDROLASE-RXN xref: RHEA:11911 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0047700 name: beta-glucoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose." [EC:2.7.1.85, MetaCyc:BETA-GLUCOSIDE-KINASE-RXN] subset: gosubset_prok synonym: "ATP:cellobiose 6-phosphotransferase activity" EXACT [EC:2.7.1.85] synonym: "b-glucoside kinase activity" EXACT [] synonym: "beta-D-glucoside kinase (phosphorylating)" EXACT [EC:2.7.1.85] xref: EC:2.7.1.85 xref: MetaCyc:BETA-GLUCOSIDE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047701 name: beta-L-arabinosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol." [EC:3.2.1.88, MetaCyc:BETA-L-ARABINOSIDASE-RXN] synonym: "b-L-arabinosidase activity" EXACT [] synonym: "beta-L-arabinoside arabinohydrolase activity" EXACT [EC:3.2.1.88] synonym: "vicianosidase activity" EXACT [EC:3.2.1.88] xref: EC:3.2.1.88 xref: MetaCyc:BETA-L-ARABINOSIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047702 name: beta-lysine 5,6-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate." [EC:5.4.3.3, RHEA:21739] subset: gosubset_prok synonym: "(3S)-3,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.3] synonym: "b-lysine 5,6-aminomutase activity" EXACT [] synonym: "beta-lysine mutase activity" EXACT [EC:5.4.3.3] synonym: "L-beta-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.3] xref: EC:5.4.3.3 xref: KEGG:R03275 xref: MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN xref: RHEA:21739 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0047703 name: beta-nitroacrylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH." [EC:1.3.1.16, RHEA:23895] synonym: "3-nitropropanoate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.16] synonym: "b-nitroacrylate reductase activity" EXACT [] xref: EC:1.3.1.16 xref: KEGG:R03900 xref: MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN xref: RHEA:23895 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047704 name: bile-salt sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "BAST I activity" NARROW [EC:2.8.2.14] synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14] synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "bile-salt sulphotransferase activity" EXACT [] synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14] xref: EC:2.8.2.14 xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047705 name: bilirubin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 bilirubin + O(2) = 2 biliverdin + 2 H(2)O." [EC:1.3.3.5, RHEA:20983] synonym: "bilirubin oxidase M-1" RELATED [EC:1.3.3.5] synonym: "bilirubin:oxygen oxidoreductase activity" EXACT [EC:1.3.3.5] xref: EC:1.3.3.5 xref: KEGG:R02394 xref: MetaCyc:BILIRUBIN-OXIDASE-RXN xref: RHEA:20983 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0047706 name: biochanin-A reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrobiochanin A + NADP(+) = biochanin A + H(+) + NADPH." [EC:1.3.1.46, RHEA:12820] synonym: "dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.46] xref: EC:1.3.1.46 xref: KEGG:R02954 xref: MetaCyc:BIOCHANIN-A-REDUCTASE-RXN xref: RHEA:12820 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047707 name: biotin-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA." [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN] synonym: "biotin CoA synthetase activity" EXACT [EC:6.2.1.11] synonym: "biotin:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.11] synonym: "biotinyl coenzyme A synthetase activity" EXACT [EC:6.2.1.11] synonym: "biotinyl-CoA synthetase activity" EXACT [EC:6.2.1.11] xref: EC:6.2.1.11 xref: MetaCyc:BIOTIN--COA-LIGASE-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047708 name: biotinidase activity namespace: molecular_function def: "Catalysis of the reaction: biotin amide + H2O = biotin + NH3." [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN] synonym: "amidohydrolase biotinidase activity" EXACT [EC:3.5.1.12] synonym: "biotin-amide amidohydrolase activity" EXACT [EC:3.5.1.12] xref: EC:3.5.1.12 xref: MetaCyc:BIOTINIDASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047709 name: bis(2-ethylhexyl)phthalate esterase activity namespace: molecular_function def: "Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H(2)O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)." [EC:3.1.1.60, RHEA:15532] synonym: "bis(2-ethylhexyl)phthalate acylhydrolase activity" EXACT [EC:3.1.1.60] synonym: "DEHP esterase activity" EXACT [EC:3.1.1.60] xref: EC:3.1.1.60 xref: KEGG:R04202 xref: MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN xref: RHEA:15532 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047710 name: bis(5'-adenosyl)-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+)." [EC:3.6.1.29, RHEA:13896] synonym: "1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29] synonym: "AP(3)A hydrolase activity" EXACT [EC:3.6.1.29] synonym: "AP(3)Aase activity" EXACT [EC:3.6.1.29] synonym: "AP3A hydrolase activity" EXACT [EC:3.6.1.29] synonym: "AP3Aase activity" EXACT [EC:3.6.1.29] synonym: "diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity" EXACT [EC:3.6.1.29] synonym: "diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity" EXACT [EC:3.6.1.29] synonym: "diadenosine 5,5-P1,P3-triphosphatase activity" EXACT [EC:3.6.1.29] synonym: "dinucleosidetriphosphatase activity" EXACT [EC:3.6.1.29] synonym: "P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29] xref: EC:3.6.1.29 xref: KEGG:R00187 xref: MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN xref: RHEA:13896 is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0047711 name: blasticidin-S deaminase activity namespace: molecular_function def: "Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3." [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN] subset: gosubset_prok synonym: "blasticidin-S aminohydrolase activity" EXACT [EC:3.5.4.23] xref: EC:3.5.4.23 xref: MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047712 name: Cypridina-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN] synonym: "Cypridina luciferase activity" EXACT [EC:1.13.12.6] synonym: "Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.6] synonym: "Cypridina-type luciferase activity" EXACT [EC:1.13.12.6] synonym: "cypridina-type luciferase activity" EXACT [EC:1.13.12.6] synonym: "luciferase (Cypridina luciferin)" EXACT [EC:1.13.12.6] synonym: "luciferase activity" BROAD [EC:1.13.12.6] xref: EC:1.13.12.6 xref: MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0047713 name: galactitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: galactitol + NAD(+) = D-tagatose + H(+) + NADH." [EC:1.1.1.16, RHEA:20688] xref: EC:1.1.1.16 xref: KEGG:R02928 xref: MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN xref: RHEA:20688 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: GO:0031320 ! hexitol dehydrogenase activity [Term] id: GO:0047714 name: galactolipase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates." [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN] synonym: "1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity" EXACT [EC:3.1.1.26] synonym: "galactolipid acylhydrolase activity" EXACT [EC:3.1.1.26] synonym: "galactolipid lipase activity" EXACT [EC:3.1.1.26] synonym: "polygalactolipase activity" EXACT [EC:3.1.1.26] xref: EC:3.1.1.26 xref: MetaCyc:GALACTOLIPASE-RXN is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047715 name: hypotaurocyamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H(+)." [EC:2.7.3.6, RHEA:24011] synonym: "ATP:hypotaurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.6] xref: EC:2.7.3.6 xref: KEGG:R03939 xref: MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN xref: RHEA:24011 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0047716 name: imidazole N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA." [EC:2.3.1.2, RHEA:15816] synonym: "acetyl-CoA:imidazole N-acetyltransferase activity" EXACT [EC:2.3.1.2] synonym: "imidazole acetylase activity" EXACT [EC:2.3.1.2] synonym: "imidazole acetyltransferase activity" EXACT [EC:2.3.1.2] xref: EC:2.3.1.2 xref: KEGG:R03621 xref: MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN xref: RHEA:15816 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047717 name: imidazoleacetate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + imidazol-4-ylacetate + NADH + O(2) = 5-hydroxyimidazole-4-acetate + H(2)O + NAD(+)." [EC:1.14.13.5, RHEA:19428] synonym: "4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.13.5] synonym: "imidazoleacetate hydroxylase activity" EXACT [EC:1.14.13.5] synonym: "imidazoleacetic hydroxylase activity" EXACT [] synonym: "imidazoleacetic monooxygenase activity" EXACT [EC:1.14.13.5] xref: EC:1.14.13.5 xref: KEGG:R04066 xref: MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN xref: RHEA:19428 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047718 name: indanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+." [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN] synonym: "indan-1-ol:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.112] xref: EC:1.1.1.112 xref: MetaCyc:INDANOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047719 name: indole 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: indole + O(2) = 2-formamidobenzaldehyde." [EC:1.13.11.17, RHEA:11215] synonym: "IDO" RELATED [EC:1.13.11.17] synonym: "indole oxidase activity" EXACT [EC:1.13.11.17] synonym: "indole-oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17] synonym: "indole:O2 oxidoreductase activity" EXACT [EC:1.13.11.17] synonym: "indole:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17] xref: EC:1.13.11.17 xref: KEGG:R02338 xref: MetaCyc:INDOLE-23-DIOXYGENASE-RXN xref: RHEA:11215 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047720 name: indoleacetaldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H(2)O." [EC:4.99.1.6, RHEA:23159] synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]" RELATED [EC:4.99.1.6] synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "3-indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "indole-3-acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "indole-3-acetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] xref: EC:4.99.1.6 xref: KEGG:R04093 xref: MetaCyc:RXN-1403 xref: RHEA:23159 is_a: GO:0016829 ! lyase activity [Term] id: GO:0047721 name: indoleacetate-lysine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H(+) + phosphate." [EC:6.3.2.20, RHEA:14860] subset: gosubset_prok synonym: "(indol-3-yl)acetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20] synonym: "IAA-lysine synthetase activity" EXACT [EC:6.3.2.20] synonym: "indoleacetate-lysine ligase activity" EXACT [] synonym: "indoleacetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20] synonym: "N-(indole-3-acetyl)-L-lysine synthetase activity" EXACT [EC:6.3.2.20] xref: EC:6.3.2.20 xref: KEGG:R03095 xref: MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN xref: RHEA:14860 is_a: GO:0010279 ! indole-3-acetic acid amido synthetase activity [Term] id: GO:0047722 name: indolelactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD(+) = 3-(indol-3-yl)pyruvate + H(+) + NADH." [EC:1.1.1.110, RHEA:20136] synonym: "(indol-3-yl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110] synonym: "indole-3-lactate dehydrogenase activity" EXACT [] synonym: "indolelactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110] xref: EC:1.1.1.110 xref: KEGG:R01971 xref: MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN xref: RHEA:20136 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047723 name: inosinate nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + IMP = D-ribose 5-phosphate + hypoxanthine." [EC:3.2.2.12, RHEA:20472] synonym: "5'-inosinate phosphoribohydrolase activity" EXACT [EC:3.2.2.12] xref: EC:3.2.2.12 xref: KEGG:R01128 xref: MetaCyc:INOSINATE-NUCLEOSIDASE-RXN xref: RHEA:20472 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047724 name: inosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine." [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN] synonym: "inosinase activity" EXACT [EC:3.2.2.2] synonym: "inosine ribohydrolase activity" EXACT [EC:3.2.2.2] synonym: "inosine-guanosine nucleosidase activity" EXACT [EC:3.2.2.2] xref: EC:3.2.2.2 xref: MetaCyc:INOSINE-NUCLEOSIDASE-RXN is_a: GO:0008477 ! purine nucleosidase activity [Term] id: GO:0047725 name: inulosucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)." [EC:2.4.1.9, MetaCyc:INULOSUCRASE-RXN] subset: gosubset_prok synonym: "sucrose 1-fructosyl transferase activity" EXACT [EC:2.4.1.9] synonym: "sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.9] synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.9] xref: EC:2.4.1.9 xref: MetaCyc:INULOSUCRASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047726 name: iron-cytochrome-c reductase activity namespace: molecular_function def: "Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+." [EC:1.9.99.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN] synonym: "ferrocytochrome-c:Fe3+ oxidoreductase activity" EXACT [EC:1.9.99.1] synonym: "iron-cytochrome c reductase activity" EXACT [EC:1.9.99.1] xref: EC:1.9.99.1 xref: MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors [Term] id: GO:0047727 name: isobutyryl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA." [EC:5.4.99.13, RHEA:13144] subset: gosubset_prok synonym: "2-methylpropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.13] synonym: "butyryl-CoA:isobutyryl-CoA mutase activity" EXACT [EC:5.4.99.13] synonym: "isobutyryl coenzyme A mutase activity" EXACT [EC:5.4.99.13] xref: EC:5.4.99.13 xref: KEGG:R01181 xref: MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN xref: RHEA:13144 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047728 name: carnitine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH." [EC:1.1.1.108, RHEA:19268] subset: gosubset_prok synonym: "carnitine:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.108] xref: EC:1.1.1.108 xref: KEGG:R02395 xref: MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN xref: RHEA:19268 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047729 name: carnitine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: carnitine + H(+) = 2-methylcholine + CO(2)." [EC:4.1.1.42, RHEA:21579] synonym: "carnitine carboxy-lyase (2-methylcholine-forming)" EXACT [EC:4.1.1.42] synonym: "carnitine carboxy-lyase activity" EXACT [EC:4.1.1.42] xref: EC:4.1.1.42 xref: KEGG:R02398 xref: MetaCyc:CARNITINE-DECARBOXYLASE-RXN xref: RHEA:21579 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047730 name: carnosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine." [EC:6.3.2.11, MetaCyc:CARNOSINE-SYNTHASE-RXN] synonym: "carnosine synthetase activity" EXACT [EC:6.3.2.11] synonym: "carnosine-anserine synthetase activity" EXACT [EC:6.3.2.11] synonym: "carnosine-homocarnosine synthetase activity" EXACT [EC:6.3.2.11] synonym: "homocarnosine-carnosine synthetase activity" EXACT [EC:6.3.2.11] synonym: "L-histidine:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.11] xref: EC:6.3.2.11 xref: MetaCyc:CARNOSINE-SYNTHASE-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047731 name: catechol oxidase (dimerizing) activity namespace: molecular_function def: "Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O." [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN] synonym: "catechol:oxygen oxidoreductase (dimerizing)" EXACT [EC:1.1.3.14] xref: EC:1.1.3.14 xref: MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047732 name: CDP-abequose epimerase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose." [EC:5.1.3.10, RHEA:21659] synonym: "CDP-3,6-dideoxy-D-glucose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-D-abequose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-paratose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-paratose epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-tyvelose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphate paratose-2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphoabequose epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphodideoxyglucose epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphoparatose epimerase activity" EXACT [EC:5.1.3.10] xref: EC:5.1.3.10 xref: KEGG:R04266 xref: MetaCyc:RXN-9160 xref: RHEA:21659 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047733 name: CDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O." [EC:4.2.1.45, RHEA:17156] subset: gosubset_prok synonym: "CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.45] synonym: "CDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45] synonym: "CDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.45] synonym: "CDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45] synonym: "cytidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.45] xref: EC:4.2.1.45 xref: KEGG:R02426 xref: MetaCyc:CDP-GLUCOSE-46-DEHYDRATASE-RXN xref: RHEA:17156 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047734 name: CDP-glycerol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+)." [EC:3.6.1.16, RHEA:21695] synonym: "CDP-glycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16] synonym: "CDP-glycerol pyrophosphatase activity" EXACT [] synonym: "CDPglycerol diphosphatase activity" EXACT [EC:3.6.1.16] synonym: "CDPglycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16] synonym: "CDPglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16] synonym: "cytidine diphosphoglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16] xref: EC:3.6.1.16 xref: KEGG:R00855 xref: MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN xref: RHEA:21695 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047735 name: cellobiose dehydrogenase (acceptor) activity namespace: molecular_function alt_id: GO:0047737 def: "Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor." [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN] synonym: "CBOR activity" RELATED [EC:1.1.99.18] synonym: "CDH activity" RELATED [EC:1.1.99.18] synonym: "cellobiose dehydrogenase (quinone) activity" NARROW [EC:1.1.99.18] synonym: "cellobiose dehydrogenase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose oxidase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose-quinone oxidoreductase activity" NARROW [EC:1.1.99.18] synonym: "cellobiose:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "phanerochaete chrysosporium cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18] xref: EC:1.1.99.18 xref: MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047736 name: cellobiose epimerase activity namespace: molecular_function def: "Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose." [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN] synonym: "cellobiose 2-epimerase activity" EXACT [EC:5.1.3.11] xref: EC:5.1.3.11 xref: MetaCyc:CELLOBIOSE-EPIMERASE-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047738 name: cellobiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.20, MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN] subset: gosubset_prok synonym: "cellobiose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.20] xref: EC:2.4.1.20 xref: MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0047739 name: cephalosporin-C deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: cephalosporin C + H(2)O = acetate + deacetylcephalosporin C + H(+)." [EC:3.1.1.41, RHEA:22599] subset: gosubset_prok synonym: "cephalosporin acetylesterase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetyl-esterase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetyl-hydrolase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetylase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetylesterase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C deacetylase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin-C acetylhydrolase activity" EXACT [EC:3.1.1.41] xref: EC:3.1.1.41 xref: KEGG:R03062 xref: MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN xref: RHEA:22599 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047740 name: cephalosporin-C transaminase activity namespace: molecular_function def: "Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C." [EC:2.6.1.74, RHEA:14556] synonym: "cephalosporin C aminotransferase activity" EXACT [EC:2.6.1.74] synonym: "cephalosporin-C:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.74] synonym: "L-alanine:cephalosporin-C aminotransferase activity" EXACT [EC:2.6.1.74] xref: EC:2.6.1.74 xref: KEGG:R03063 xref: MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN xref: RHEA:14556 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047741 name: cetraxate benzylesterase activity namespace: molecular_function def: "Catalysis of the reaction: benzyl cetraxate + H(2)O = benzyl alcohol + cetraxate + H(+)." [EC:3.1.1.70, RHEA:23463] synonym: "cetraxate-benzyl-ester benzylhydrolase activity" EXACT [EC:3.1.1.70] xref: EC:3.1.1.70 xref: KEGG:R03612 xref: MetaCyc:CETRAXATE-BENZYLESTERASE-RXN xref: RHEA:23463 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047742 name: chenodeoxycholoyltaurine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine." [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN] synonym: "chenodeoxycholoyltaurine amidohydrolase activity" EXACT [EC:3.5.1.74] xref: EC:3.5.1.74 xref: MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047743 name: chlordecone reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH." [EC:1.1.1.225, RHEA:14404] synonym: "CDR activity" RELATED [EC:1.1.1.225] synonym: "chlordecone-alcohol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.225] xref: EC:1.1.1.225 xref: KEGG:R03716 xref: MetaCyc:CHLORDECONE-REDUCTASE-RXN xref: RHEA:14404 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047744 name: chloridazon-catechol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O(2) = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)." [EC:1.13.11.36, RHEA:20452] synonym: "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.36] xref: EC:1.13.11.36 xref: KEGG:R04602 xref: MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN xref: RHEA:20452 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047745 name: chlorogenate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: chlorogenate + H(2)O = (-)-quinate + cis-caffeate + H(+)." [EC:3.1.1.42, RHEA:20692] synonym: "chlorogenase activity" EXACT [EC:3.1.1.42] synonym: "chlorogenic acid esterase activity" EXACT [EC:3.1.1.42] xref: EC:3.1.1.42 xref: KEGG:R02997 xref: MetaCyc:CHLOROGENATE-HYDROLASE-RXN xref: RHEA:20692 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047746 name: chlorophyllase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide." [EC:3.1.1.14, MetaCyc:CHLOROPHYLLASE-RXN] synonym: "chlorophyll chlorophyllidohydrolase activity" EXACT [EC:3.1.1.14] xref: EC:3.1.1.14 xref: MetaCyc:CHLOROPHYLLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047747 name: cholate-CoA ligase activity namespace: molecular_function alt_id: GO:0047477 def: "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7, MetaCyc:CHOLATE--COA-LIGASE-RXN] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity" EXACT [] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] synonym: "BAL activity" RELATED [EC:6.2.1.29] synonym: "bile acid CoA ligase activity" RELATED [EC:6.2.1.29] synonym: "bile acid coenzyme A ligase activity" RELATED [EC:6.2.1.29] synonym: "cholate thiokinase activity" EXACT [EC:6.2.1.29] synonym: "cholate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29] synonym: "cholic acid:CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "cholic thiokinase activity" EXACT [EC:6.2.1.29] synonym: "choloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] synonym: "choloyl-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "cholyl-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "THCA-CoA ligase activity" RELATED [EC:6.2.1.29] synonym: "trihydroxycoprostanoyl-CoA synthetase activity" RELATED [EC:6.2.1.29] xref: EC:6.2.1.7 xref: MetaCyc:CHOLATE--COA-LIGASE-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047748 name: cholestanetetraol 26-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [EC:1.1.1.161, MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN] synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT [EC:1.1.1.161] synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT [EC:1.1.1.161] synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT [EC:1.1.1.161] synonym: "TEHC-NAD oxidoreductase activity" EXACT [EC:1.1.1.161] xref: EC:1.1.1.161 xref: MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047749 name: cholestanetriol 26-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O." [EC:1.14.13.15, MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN] synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15] synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity" BROAD [EC:1.14.13.15] synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15] synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity" EXACT [EC:1.14.13.15] synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)" EXACT [EC:1.14.13.15] synonym: "cholestanetriol 26-hydroxylase activity" EXACT [] synonym: "cholesterol 27-hydroxylase activity" RELATED [EC:1.14.13.15] synonym: "CYP27A" RELATED [EC:1.14.13.15] synonym: "CYP27A1" RELATED [EC:1.14.13.15] synonym: "cytochrome P450 27A1' activity" NARROW [EC:1.14.13.15] synonym: "sterol 26-hydroxylase activity" BROAD [EC:1.14.13.15] synonym: "sterol 27-hydroxylase activity" RELATED [EC:1.14.13.15] xref: EC:1.14.13.15 xref: MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047750 name: cholestenol delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [EC:5.3.3.5, MetaCyc:CHOLESTENOL-DELTA-ISOMERASE-RXN] synonym: "cholestenol D-isomerase activity" EXACT [] synonym: "delta7-cholestenol delta7-delta8-isomerase activity" EXACT [EC:5.3.3.5] xref: EC:5.3.3.5 xref: MetaCyc:RXN66-25 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0047751 name: cholestenone 5-alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH." [EC:1.3.1.22, RHEA:24555] synonym: "3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.22] synonym: "3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.1.22] synonym: "4-ene-3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "4-ene-5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "5alpha-reductase" BROAD [EC:1.3.1.22] synonym: "cholest-4-en-3-one 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "cholestenone 5a-reductase activity" EXACT [] synonym: "cholestenone 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22] synonym: "reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22] synonym: "steroid 5alpha-hydrogenase activity" EXACT [EC:1.3.1.22] synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.1.22] synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.1.22] synonym: "testosterone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "testosterone delta4-hydrogenase activity" EXACT [EC:1.3.1.22] xref: EC:1.3.1.22 xref: KEGG:R02610 xref: MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN xref: RHEA:24555 is_a: GO:0035671 ! enone reductase activity [Term] id: GO:0047753 name: choline-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: choline sulfate + H(2)O = choline + H(+) + sulfate." [EC:3.1.6.6, RHEA:20823] subset: gosubset_prok synonym: "choline-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.6] synonym: "choline-sulphatase activity" EXACT [] xref: EC:3.1.6.6 xref: KEGG:R01028 xref: MetaCyc:CHOLINE-SULFATASE-RXN xref: RHEA:20823 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0047754 name: choline sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H(+)." [EC:2.8.2.6, RHEA:21987] synonym: "3'-phosphoadenylyl-sulfate:choline sulfotransferase activity" EXACT [EC:2.8.2.6] synonym: "choline sulphokinase activity" EXACT [EC:2.8.2.6] synonym: "choline sulphotransferase activity" EXACT [] xref: EC:2.8.2.6 xref: KEGG:R01027 xref: MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN xref: RHEA:21987 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047755 name: isocitrate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate." [EC:5.1.2.6, RHEA:10823] synonym: "(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity" EXACT [EC:5.1.2.6] xref: EC:5.1.2.6 xref: KEGG:R02318 xref: MetaCyc:ISOCITRATE-EPIMERASE-RXN xref: RHEA:10823 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0047756 name: chondroitin 4-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate." [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity" EXACT [EC:2.8.2.5] synonym: "chondroitin 4-sulphotransferase activity" EXACT [] xref: EC:2.8.2.5 xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN is_a: GO:0034481 ! chondroitin sulfotransferase activity [Term] id: GO:0047757 name: chondroitin-glucuronate 5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN] synonym: "chondroitin D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.19] synonym: "chondroitin-D-glucuronate 5-epimerase activity" EXACT [EC:5.1.3.19] synonym: "dermatan-sulfate 5-epimerase activity" EXACT [EC:5.1.3.19] synonym: "polyglucuronate 5-epimerase activity" RELATED [EC:5.1.3.19] synonym: "urunosyl C-5 epimerase activity" EXACT [EC:5.1.3.19] xref: EC:5.1.3.19 xref: MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047758 name: ATP:2-methylpropanoate phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H(+)." [EC:2.7.2.14, RHEA:24159] synonym: "ATP:2-methylpropanoate 1-phosphotransferase activity" EXACT [] synonym: "ATP:2-methylpropanoate kinase activity" EXACT [] synonym: "ATP:branched-chain-fatty-acid 1-phosphotransferase activity" EXACT [EC:2.7.2.14] synonym: "ATP:branched-chain-fatty-acid 1-phosphotransferase activity" BROAD [KEGG:R04002] synonym: "ATP:isobutyrate 1-phosphotransferase activity" EXACT [] synonym: "branched-chain fatty acid kinase activity" BROAD [EC:2.7.2.14] synonym: "branched-chain-fatty-acid kinase activity" BROAD [EC:2.7.2.14] synonym: "isobutyrate kinase activity" BROAD [EC:2.7.2.14] xref: EC:2.7.2.14 xref: KEGG:R04002 xref: MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN xref: RHEA:24159 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047759 name: butanal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+." [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN] synonym: "butanal:NAD(P)+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.57] xref: EC:1.2.1.57 xref: MetaCyc:BUTANAL-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047760 name: butyrate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA." [EC:6.2.1.2, MetaCyc:BUTYRATE--COA-LIGASE-RXN] synonym: "acyl-activating enzyme activity" RELATED [EC:6.2.1.2] synonym: "butanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.2] synonym: "butyryl-CoA synthetase activity" EXACT [EC:6.2.1.2] synonym: "butyryl-coenzyme A synthetase activity" EXACT [EC:6.2.1.2] synonym: "fatty acid activating enzyme" RELATED [EC:6.2.1.2] synonym: "fatty acid thiokinase (medium chain) activity" RELATED [EC:6.2.1.2] synonym: "fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.2] synonym: "L-(+)-3-hydroxybutyryl CoA ligase activity" EXACT [EC:6.2.1.2] synonym: "medium chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2] synonym: "short-chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2] xref: EC:6.2.1.2 xref: MetaCyc:BUTYRATE--COA-LIGASE-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047761 name: butyrate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H(+)." [EC:2.7.2.7, RHEA:13588] subset: gosubset_prok synonym: "ATP:butanoate 1-phosphotransferase activity" EXACT [EC:2.7.2.7] xref: EC:2.7.2.7 xref: KEGG:R01688 xref: MetaCyc:BUTYRATE-KINASE-RXN xref: RHEA:13588 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047762 name: caffeate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-caffeate + O(2) = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)." [EC:1.13.11.22, RHEA:22219] synonym: "3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.22] xref: EC:1.13.11.22 xref: KEGG:R03365 xref: MetaCyc:CAFFEATE-34-DIOXYGENASE-RXN xref: RHEA:22219 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047763 name: caffeate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate." [EC:2.1.1.68, MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN] synonym: "caffeate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68] synonym: "caffeate methyltransferase activity" EXACT [EC:2.1.1.68] synonym: "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68] synonym: "S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity" EXACT [EC:2.1.1.68] xref: EC:2.1.1.68 xref: MetaCyc:RXN-1104 is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0047764 name: caldesmon kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate." [GOC:curators] xref: MetaCyc:2.7.11.17-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0047765 name: caldesmon-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate." [EC:3.1.3.55, MetaCyc:CALDESMON-PHOSPHATASE-RXN] synonym: "caldesmon-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.55] synonym: "smooth muscle caldesmon phosphatase activity" EXACT [EC:3.1.3.55] synonym: "SMP-I" RELATED [EC:3.1.3.55] xref: EC:3.1.3.55 xref: MetaCyc:CALDESMON-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047766 name: carbamoyl-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: O-carbamoyl-L-serine + H(2)O + H(+) = CO(2) + 2 NH(4)(+) + pyruvate." [EC:4.3.1.13, RHEA:15448] synonym: "carbamoylserine deaminase activity" EXACT [EC:4.3.1.13] synonym: "O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)" EXACT [EC:4.3.1.13] synonym: "O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.13] synonym: "O-carbamoyl-L-serine deaminase activity" EXACT [EC:4.3.1.13] xref: EC:4.3.1.13 xref: KEGG:R00213 xref: MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN xref: RHEA:15448 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047768 name: carboxy-cis,cis-muconate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.5, RHEA:14980] synonym: "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.5] synonym: "3-carboxy-cis,cis-muconate lactonizing enzyme activity" EXACT [EC:5.5.1.5] synonym: "3-carboxymuconate cyclase activity" EXACT [EC:5.5.1.5] xref: EC:5.5.1.5 xref: KEGG:R03308 xref: MetaCyc:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN xref: RHEA:14980 is_a: GO:0009975 ! cyclase activity is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0047769 name: arogenate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2." [EC:4.2.1.91, MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN] subset: gosubset_prok synonym: "carboxycyclohexadienyl dehydratase activity" EXACT [] synonym: "L-arogenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.91] synonym: "L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)" EXACT [EC:4.2.1.91] xref: EC:4.2.1.91 xref: MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047770 name: carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor." [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN] synonym: "aldehyde:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.6] synonym: "aldehyde:acceptor oxidoreductase activity" EXACT [EC:1.2.99.6] synonym: "carboxylic acid reductase activity" EXACT [EC:1.2.99.6] xref: EC:1.2.99.6 xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0047771 name: carboxymethylhydantoinase activity namespace: molecular_function def: "Catalysis of the reaction: L-5-carboxymethylhydantoin + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.4, RHEA:12031] synonym: "hydantoin hydrolase activity" EXACT [EC:3.5.2.4] synonym: "L-5-carboxymethylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.4] xref: EC:3.5.2.4 xref: KEGG:R02284 xref: MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN xref: RHEA:12031 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047772 name: carboxymethyloxysuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate." [EC:4.2.99.12, RHEA:12339] synonym: "carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)" EXACT [EC:4.2.99.12] synonym: "carboxymethyloxysuccinate glycolate-lyase activity" EXACT [EC:4.2.99.12] xref: EC:4.2.99.12 xref: KEGG:R01336 xref: MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN xref: RHEA:12339 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0047773 name: carnitinamidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-carnitinamide + H(2)O = (R)-carnitine + NH(4)(+)." [EC:3.5.1.73, RHEA:17540] synonym: "carnitine amidase activity" EXACT [EC:3.5.1.73] synonym: "L-carnitinamidase activity" EXACT [EC:3.5.1.73] synonym: "L-carnitinamide amidohydrolase activity" EXACT [EC:3.5.1.73] synonym: "L-carnitine amidase activity" EXACT [EC:3.5.1.73] xref: EC:3.5.1.73 xref: KEGG:R01922 xref: MetaCyc:CARNITINAMIDASE-RXN xref: RHEA:17540 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047774 name: cis-2-enoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH." [EC:1.3.1.37, MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN] synonym: "acyl-CoA:NADP+ cis-2-oxidoreductase activity" EXACT [EC:1.3.1.37] synonym: "cis-2-enoyl-coenzyme A reductase activity" EXACT [EC:1.3.1.37] synonym: "NADPH-dependent cis-enoyl-CoA reductase activity" EXACT [EC:1.3.1.37] synonym: "reductase, cis-2-enoyl coenzyme A" EXACT [EC:1.3.1.37] xref: EC:1.3.1.37 xref: MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047775 name: citramalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA." [EC:2.8.3.11, MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN] synonym: "acetyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.11] xref: EC:2.8.3.11 xref: MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047776 name: citramalate lyase activity namespace: molecular_function def: "Catalysis of the reaction: S-citramalate = acetate + pyruvate." [EC:4.1.3.22, RHEA:15548] synonym: "(+)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] synonym: "(3S)-citramalate pyruvate-lyase (acetate-forming)" EXACT [EC:4.1.3.22] synonym: "(3S)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] synonym: "(S)-citramalate lyase activity" EXACT [EC:4.1.3.22] synonym: "citramalate pyruvate lyase activity" EXACT [EC:4.1.3.22] synonym: "citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] synonym: "citramalate synthetase activity" EXACT [EC:4.1.3.22] synonym: "citramalic synthase activity" EXACT [EC:4.1.3.22] synonym: "citramalic-condensing enzyme" RELATED [EC:4.1.3.22] xref: EC:4.1.3.22 xref: KEGG:R00325 xref: MetaCyc:CITRAMALATE-LYASE-RXN xref: RHEA:15548 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047777 name: (3S)-citramalyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate." [EC:4.1.3.25, RHEA:22615] synonym: "(+)-CMA-CoA lyase activity" EXACT [EC:4.1.3.25] synonym: "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.25] synonym: "(3S)-citramalyl-CoA pyruvate-lyase activity" EXACT [EC:4.1.3.25] synonym: "citramalyl coenzyme A lyase activity" EXACT [EC:4.1.3.25] synonym: "citramalyl-CoA lyase activity" BROAD [] xref: EC:4.1.3.25 xref: KEGG:R00237 xref: MetaCyc:CITRAMALYL-COA-LYASE-RXN xref: RHEA:22615 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047778 name: [citrate-(pro-3S)-lyase] thiolesterase activity namespace: molecular_function def: "Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate." [EC:3.1.2.16, MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN] synonym: "[citrate-(pro-3S)-lyase] thioesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate (pro-3S)-lyase thiolesterase activity" EXACT [] synonym: "citrate lyase deacetylase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase thioesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase thiolesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" EXACT [EC:3.1.2.16] xref: EC:3.1.2.16 xref: MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0047779 name: citrate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H(+) + phosphate." [EC:6.2.1.18, RHEA:21475] synonym: "citrate thiokinase activity" EXACT [EC:6.2.1.18] synonym: "citrate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.18] synonym: "citrate:CoA ligase activity" EXACT [EC:6.2.1.18] synonym: "citryl-CoA synthetase activity" EXACT [EC:6.2.1.18] xref: EC:6.2.1.18 xref: KEGG:R01322 xref: MetaCyc:CITRATE--COA-LIGASE-RXN xref: RHEA:21475 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047780 name: citrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = cis-aconitate + H2O." [EC:4.2.1.4, MetaCyc:CITRATE-DEHYDRATASE-RXN] synonym: "citrate hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.4] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.4] xref: EC:4.2.1.4 xref: KEGG:R01325 xref: MetaCyc:CITRATE-DEHYDRATASE-RXN xref: RHEA:10231 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047781 name: citrullinase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine." [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN] synonym: "citrulline hydrolase activity" EXACT [EC:3.5.1.20] synonym: "citrulline ureidase activity" EXACT [EC:3.5.1.20] synonym: "L-citrulline 5-N-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20] synonym: "L-citrulline N5-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20] xref: EC:3.5.1.20 xref: MetaCyc:CITRULLINASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047782 name: coniferin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol." [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN] synonym: "coniferin b-glucosidase activity" EXACT [] synonym: "coniferin beta-D-glucosidase activity" EXACT [EC:3.2.1.126] synonym: "coniferin-hydrolyzing beta-glucosidase activity" EXACT [EC:3.2.1.126] xref: EC:3.2.1.126 xref: MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0047783 name: corticosterone 18-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.5, MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN] synonym: "corticosterone 18-hydroxylase activity" EXACT [] synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5] synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" EXACT [EC:1.14.15.5] xref: EC:1.14.15.5 xref: MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047784 name: cortisol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate." [EC:2.3.1.27, RHEA:17076] synonym: "acetyl-CoA:cortisol O-acetyltransferase activity" EXACT [EC:2.3.1.27] synonym: "corticosteroid acetyltransferase activity" EXACT [EC:2.3.1.27] synonym: "corticosteroid-21-O-acetyltransferase activity" EXACT [EC:2.3.1.27] synonym: "cortisol acetyltransferase activity" EXACT [EC:2.3.1.27] xref: EC:2.3.1.27 xref: KEGG:R02837 xref: MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN xref: RHEA:17076 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047785 name: cortisol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H(+)." [EC:2.8.2.18, RHEA:11887] synonym: "3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity" EXACT [EC:2.8.2.18] synonym: "cortisol sulphotransferase activity" EXACT [] synonym: "glucocorticoid sulfotransferase activity" EXACT [EC:2.8.2.18] synonym: "glucocorticosteroid sulfotransferase activity" BROAD [EC:2.8.2.18] xref: EC:2.8.2.18 xref: KEGG:R02839 xref: MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN xref: RHEA:11887 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047786 name: cortisone alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5alpha-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH." [EC:1.3.1.4, RHEA:17984] synonym: "4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.4] synonym: "cortisone a-reductase activity" EXACT [] synonym: "cortisone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4] synonym: "delta4-3-ketosteroid reductase (5alpha)" EXACT [EC:1.3.1.4] synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.1.4] synonym: "delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4] synonym: "microsomal steroid reductase (5alpha)" EXACT [EC:1.3.1.4] synonym: "NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.1.4] xref: EC:1.3.1.4 xref: KEGG:R02892 xref: MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN xref: RHEA:17984 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047787 name: delta4-3-oxosteroid 5beta-reductase activity namespace: molecular_function alt_id: GO:0047752 def: "Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+." [EC:1.3.1.3, MetaCyc:CORTISONE-BETA-REDUCTASE-RXN] synonym: "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23] synonym: "3-oxo-Delta(4)-steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "3-oxo-delta4-steroid 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23] synonym: "5-beta-reductase activity" BROAD [EC:1.3.1.23] synonym: "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity" EXACT [EC:1.3.1.23] synonym: "5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "androstenedione 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "androstenedione 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cholestenone 5-beta-reductase activity" EXACT [] synonym: "cholestenone 5b-reductase activity" EXACT [] synonym: "cholestenone 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone b-reductase activity" EXACT [] synonym: "cortisone beta-reductase activity" EXACT [] synonym: "cortisone delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone delta4-5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta(4)-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta(4)-hydrogenase activity" EXACT [EC:1.3.1.23] synonym: "delta-4-3-oxosteroid 5-beta-reductase activity" EXACT [] synonym: "delta4-3-ketosteroid 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta4-5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta4-hydrogenase activity" EXACT [EC:1.3.1.23] synonym: "steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "steroid 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "testosterone 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "testosterone 5beta-reductase activity" EXACT [EC:1.3.1.23] xref: EC:1.3.1.3 xref: MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN xref: MetaCyc:CORTISONE-BETA-REDUCTASE-RXN is_a: GO:0035671 ! enone reductase activity [Term] id: GO:0047788 name: 2-coumarate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD(+) = trans-2-coumarate + H(+) + NADH." [EC:1.3.1.11, RHEA:21447] synonym: "3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.11] synonym: "coumarate reductase activity" EXACT [] synonym: "melilotate dehydrogenase activity" EXACT [EC:1.3.1.11] xref: EC:1.3.1.11 xref: KEGG:R03709 xref: MetaCyc:COUMARATE-REDUCTASE-RXN xref: RHEA:21447 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047789 name: creatininase activity namespace: molecular_function def: "Catalysis of the reaction: creatinine + H(2)O = creatine." [EC:3.5.2.10, RHEA:14536] subset: gosubset_prok synonym: "creatinine amidohydrolase activity" EXACT [EC:3.5.2.10] synonym: "creatinine hydrolase" BROAD [EC:3.5.2.10] xref: EC:3.5.2.10 xref: KEGG:R01884 xref: MetaCyc:CREATININASE-RXN xref: RHEA:14536 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047790 name: creatinine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3." [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN] subset: gosubset_prok synonym: "creatinine desiminase activity" EXACT [EC:3.5.4.21] synonym: "creatinine hydrolase" BROAD [EC:3.5.4.21] synonym: "creatinine iminohydrolase activity" EXACT [EC:3.5.4.21] xref: EC:3.5.4.21 xref: MetaCyc:CREATININE-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047791 name: cucurbitacin delta23-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+." [EC:1.3.1.5, MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN] synonym: "23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity" EXACT [EC:1.3.1.5] synonym: "cucurbitacin D23-reductase activity" EXACT [] synonym: "cucurbitacin delta(23) reductase activity" EXACT [] synonym: "NAD(P)H: cucurbitacin B delta23-oxidoreductase activity" EXACT [EC:1.3.1.5] xref: EC:1.3.1.5 xref: MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047792 name: cyanohydrin beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside." [EC:2.4.1.85, MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "cyanohydrin b-glucosyltransferase activity" EXACT [] synonym: "UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UGT85B1 activity" NARROW [EC:2.4.1.85] synonym: "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.85] xref: EC:2.4.1.85 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047793 name: cycloeucalenol cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: cycloeucalenol = obtusifoliol." [EC:5.5.1.9, RHEA:22803] synonym: "cycloeucalenol lyase (cyclopropane-decyclizing)" EXACT [EC:5.5.1.9] synonym: "cycloeucalenol--obtusifoliol isomerase activity" EXACT [EC:5.5.1.9] synonym: "cycloeucalenol-obtusifoliol isomerase activity" EXACT [] xref: EC:5.5.1.9 xref: KEGG:R03775 xref: MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN xref: RHEA:22803 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0047794 name: cyclohexadienyl dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2." [EC:1.3.1.43, MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "arogenate dehydrogenase activity" EXACT [EC:1.3.1.43] synonym: "arogenic dehydrogenase activity" EXACT [EC:1.3.1.43] synonym: "L-arogenate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.43] synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.43] synonym: "L-arogenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.43] synonym: "pretyrosine dehydrogenase activity" EXACT [EC:1.3.1.43] xref: EC:1.3.1.43 xref: MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047795 name: cyclohexane-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH." [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN] synonym: "trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.174] xref: EC:1.1.1.174 xref: MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047796 name: cyclohexane-1,3-dione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexane-1,3-dione + H(2)O = 5-oxohexanoate + H(+)." [EC:3.7.1.10, RHEA:16476] synonym: "1,3-cyclohexanedione hydrolase activity" EXACT [EC:3.7.1.10] synonym: "cyclohexane-1,3-dione acylhydrolase (decyclizing)" EXACT [EC:3.7.1.10] xref: EC:3.7.1.10 xref: KEGG:R03211 xref: MetaCyc:CYCLOHEXANE-13-DIONE-HYDROLASE-RXN xref: RHEA:16476 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0047797 name: cyclohexanone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone." [EC:1.3.99.14, RHEA:21783] synonym: "cyclohexanone:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.3.99.14] synonym: "cyclohexanone:acceptor 2-oxidoreductase activity" EXACT [EC:1.3.99.14] xref: EC:1.3.99.14 xref: KEGG:R02234 xref: MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN xref: RHEA:21783 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047798 name: cyclomaltodextrinase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin." [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN] subset: gosubset_prok synonym: "cyclodextrinase activity" EXACT [EC:3.2.1.54] synonym: "cycloheptaglucanase activity" EXACT [EC:3.2.1.54] synonym: "cyclohexaglucanase activity" EXACT [EC:3.2.1.54] synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" EXACT [EC:3.2.1.54] xref: EC:3.2.1.54 xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047799 name: cyclopentanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopentanone + H(+) + NADPH + O(2) = 5-valerolactone + H(2)O + NADP(+)." [EC:1.14.13.16, RHEA:15740] synonym: "cyclopentanone 1,2-monooxygenase activity" EXACT [EC:1.14.13.16] synonym: "cyclopentanone oxygenase activity" EXACT [EC:1.14.13.16] synonym: "cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)" EXACT [EC:1.14.13.16] xref: EC:1.14.13.16 xref: KEGG:R02554 xref: MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN xref: RHEA:15740 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047800 name: cysteamine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine." [EC:1.13.11.19, RHEA:14412] synonym: "2-aminoethanethiol:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19] synonym: "cysteamine oxygenase activity" EXACT [EC:1.13.11.19] synonym: "cysteamine:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19] synonym: "persulfurase activity" RELATED [EC:1.13.11.19] xref: EC:1.13.11.19 xref: KEGG:R02467 xref: MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN xref: RHEA:14412 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047801 name: L-cysteine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate." [EC:2.6.1.3, MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN] synonym: "CGT" RELATED [EC:2.6.1.3] synonym: "cysteine aminotransferase activity" BROAD [] synonym: "cysteine transaminase activity" BROAD [EC:2.6.1.3] synonym: "L-cysteine aminotransferase activity" BROAD [EC:2.6.1.3] xref: EC:2.6.1.3 xref: MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047802 name: cysteine-conjugate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate." [EC:2.6.1.75, RHEA:13488] synonym: "cysteine conjugate aminotransferase activity" EXACT [EC:2.6.1.75] synonym: "cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)" EXACT [EC:2.6.1.75] synonym: "S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.75] xref: EC:2.6.1.75 xref: KEGG:R04338 xref: MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN xref: RHEA:13488 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047803 name: cysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide." [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN] synonym: "cysteine (sulfite) lyase activity" EXACT [EC:4.4.1.10] synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite)" EXACT [EC:4.4.1.10] synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)" EXACT [EC:4.4.1.10] xref: EC:4.4.1.10 xref: MetaCyc:CYSTEINE-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047804 name: cysteine-S-conjugate beta-lyase activity namespace: molecular_function def: "Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate." [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN] subset: gosubset_prok synonym: "cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13] synonym: "cysteine-S-conjugate b-lyase activity" EXACT [] synonym: "glutamine transaminase K/cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13] synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" EXACT [EC:4.4.1.13] synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.13] xref: EC:4.4.1.13 xref: MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047805 name: cytidylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+)." [EC:4.6.1.6, RHEA:14740] synonym: "3',5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6] synonym: "3'5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6] synonym: "CTP diphosphate-lyase (cyclizing)" EXACT [EC:4.6.1.6] synonym: "CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)" EXACT [EC:4.6.1.6] synonym: "cytidyl cyclase activity" EXACT [EC:4.6.1.6] synonym: "cytidylyl cyclase activity" EXACT [EC:4.6.1.6] xref: EC:4.6.1.6 xref: KEGG:R00574 xref: MetaCyc:CYTIDYLATE-CYCLASE-RXN xref: RHEA:14740 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0047806 name: cytochrome-c3 hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3." [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN] subset: gosubset_prok synonym: "cytochrome c3 reductase activity" EXACT [EC:1.12.2.1] synonym: "cytochrome hydrogenase activity" BROAD [EC:1.12.2.1] synonym: "H(2):ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1] synonym: "H2:ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1] synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" EXACT [EC:1.12.2.1] xref: EC:1.12.2.1 xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN xref: UM-BBD_enzymeID:e0481 is_a: GO:0016697 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor [Term] id: GO:0047807 name: cytokinin 7-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [EC:2.4.1.118, MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "cytokinin 7-b-glucosyltransferase activity" EXACT [] synonym: "cytokinin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "UDP-glucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "UDP-glucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "UDPglucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "uridine diphosphoglucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] xref: EC:2.4.1.118 xref: KEGG:R04071 xref: MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:23275 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047808 name: D(-)-tartrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-tartrate = H(2)O + oxaloacetate." [EC:4.2.1.81, RHEA:18292] synonym: "(S,S)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.81] synonym: "(S,S)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.81] synonym: "D-tartrate dehydratase activity" EXACT [EC:4.2.1.81] xref: EC:4.2.1.81 xref: KEGG:R00340 xref: MetaCyc:D--TARTRATE-DEHYDRATASE-RXN xref: RHEA:18292 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047809 name: D-2-hydroxy-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate." [EC:1.1.99.6, RHEA:15092] synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.6] synonym: "2-hydroxy acid dehydrogenase activity" EXACT [EC:1.1.99.6] xref: EC:1.1.99.6 xref: KEGG:R00297 xref: MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN xref: RHEA:15092 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047810 name: D-alanine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate." [EC:2.6.1.21, MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN] subset: gosubset_prok synonym: "D-alanine aminotransferase activity" EXACT [] synonym: "D-alanine transaminase activity" BROAD [EC:2.6.1.21] synonym: "D-alanine-D-glutamate transaminase activity" EXACT [EC:2.6.1.21] synonym: "D-amino acid aminotransferase activity" BROAD [EC:2.6.1.21] synonym: "D-amino acid transaminase activity" BROAD [EC:2.6.1.21] synonym: "D-amino-acid transaminase activity" BROAD [EC:2.6.1.21] synonym: "D-aspartate aminotransferase activity" RELATED [EC:2.6.1.21] synonym: "D-aspartate transaminase activity" RELATED [EC:2.6.1.21] synonym: "D-aspartic aminotransferase activity" RELATED [EC:2.6.1.21] xref: EC:2.6.1.21 xref: MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047811 name: D-alanine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH(4)(+)." [EC:2.3.2.14, RHEA:23559] synonym: "D-alanine g-glutamyltransferase activity" EXACT [] synonym: "L-glutamine:D-alanine gamma-glutamyltransferase activity" EXACT [EC:2.3.2.14] xref: EC:2.3.2.14 xref: KEGG:R01149 xref: MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN xref: RHEA:23559 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047812 name: D-amino-acid N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid." [EC:2.3.1.36, MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:D-amino-acid N-acetyltransferase activity" EXACT [EC:2.3.1.36] synonym: "D-amino acid acetyltransferase activity" EXACT [EC:2.3.1.36] synonym: "D-amino acid-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.36] xref: EC:2.3.1.36 xref: MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047813 name: D-arabinitol 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH." [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN] subset: gosubset_prok xref: EC:1.1.1.11 xref: MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047814 name: D-arabinokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP." [EC:2.7.1.54, RHEA:24591] synonym: "ATP:D-arabinose 5-phosphotransferase activity" EXACT [EC:2.7.1.54] synonym: "D-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.54] xref: EC:2.7.1.54 xref: KEGG:R01573 xref: MetaCyc:D-ARABINOKINASE-RXN xref: RHEA:24591 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047815 name: D-arabinonolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinono-1,4-lactone + H(2)O = D-arabinonate + H(+)." [EC:3.1.1.30, RHEA:23111] synonym: "D-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.30] xref: EC:3.1.1.30 xref: KEGG:R02714 xref: MetaCyc:D-ARABINONOLACTONASE-RXN xref: RHEA:23111 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047816 name: D-arabinose 1-dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN] synonym: "arabinose(fucose)dehydrogenase activity" EXACT [EC:1.1.1.116] synonym: "D-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.116] synonym: "NAD-pentose-dehydrogenase activity" EXACT [EC:1.1.1.116] xref: EC:1.1.1.116 xref: MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047817 name: D-arginase activity namespace: molecular_function def: "Catalysis of the reaction: D-arginine + H(2)O = D-ornithine + urea." [EC:3.5.3.10, RHEA:12904] synonym: "D-arginine amidinohydrolase activity" EXACT [EC:3.5.3.10] xref: EC:3.5.3.10 xref: KEGG:R02458 xref: MetaCyc:D-ARGINASE-RXN xref: RHEA:12904 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047818 name: D-fuconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H(2)O." [EC:4.2.1.67, RHEA:12952] synonym: "D-fuconate hydratase activity" EXACT [] synonym: "D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)" EXACT [EC:4.2.1.67] synonym: "D-fuconate hydro-lyase activity" EXACT [EC:4.2.1.67] xref: EC:4.2.1.67 xref: KEGG:R03671 xref: MetaCyc:D-FUCONATE-HYDRATASE-RXN xref: RHEA:12952 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047819 name: D-glutamate(D-aspartate) oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.15, MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN] synonym: "D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.15] synonym: "D-glutamic-aspartic oxidase activity" EXACT [EC:1.4.3.15] synonym: "D-monoaminodicarboxylic acid oxidase activity" EXACT [EC:1.4.3.15] xref: EC:1.4.3.15 xref: MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0047820 name: D-glutamate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H(2)O." [EC:4.2.1.48, RHEA:22363] synonym: "D-glutamate hydro-lyase (cyclizing)" EXACT [EC:4.2.1.48] synonym: "D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)" EXACT [EC:4.2.1.48] xref: EC:4.2.1.48 xref: KEGG:R01583 xref: MetaCyc:D-GLUTAMATE-CYCLASE-RXN xref: RHEA:22363 is_a: GO:0009975 ! cyclase activity is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047821 name: D-glutamate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2; D-aspartate + H2O = oxaloacetate + NH3 + H2O2." [BRENDA:1.4.3.15, EC:1.4.3.7, MetaCyc:D-GLUTAMATE-OXIDASE-RXN] synonym: "D-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.7] synonym: "D-glutamic acid oxidase activity" EXACT [EC:1.4.3.7] synonym: "D-glutamic oxidase activity" EXACT [EC:1.4.3.7] xref: EC:1.4.3.7 xref: MetaCyc:D-GLUTAMATE-OXIDASE-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0047822 name: hypotaurine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + hypotaurine + NAD(+) = H(+) + NADH + taurine." [EC:1.8.1.3, RHEA:17388] synonym: "hypotaurine:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.3] xref: EC:1.8.1.3 xref: KEGG:R01681 xref: MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN xref: RHEA:17388 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0047823 name: D-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide." [EC:2.3.2.1, MetaCyc:D-GLUTAMYLTRANSFERASE-RXN] synonym: "D-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1] synonym: "D-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1] synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" EXACT [EC:2.3.2.1] xref: EC:2.3.2.1 xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047824 name: D-iditol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH." [EC:1.1.1.15, MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN] xref: EC:1.1.1.15 xref: MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: GO:0031320 ! hexitol dehydrogenase activity [Term] id: GO:0047825 name: D-lactate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-O-sulfolactate + H(2)O = (R)-lactate + H(+) + sulfate." [EC:3.1.6.17, RHEA:20340] synonym: "(S)-2-O-sulfolactate 2-sulfohydrolase activity" EXACT [EC:3.1.6.17] synonym: "D-lactate-2-sulphatase activity" EXACT [] xref: EC:3.1.6.17 xref: KEGG:R01448 xref: MetaCyc:D-LACTATE-2-SULFATASE-RXN xref: RHEA:20340 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0047826 name: D-lysine 5,6-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate." [EC:5.4.3.4, RHEA:18244] synonym: "adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.4] synonym: "D-2,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.4] synonym: "D-alpha-lysine mutase activity" EXACT [EC:5.4.3.4] xref: EC:5.4.3.4 xref: KEGG:R02852 xref: MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN xref: RHEA:18244 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0047827 name: D-lysopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-lysopine + H(2)O + NADP(+) = L-lysine + H(+) + NADPH + pyruvate." [EC:1.5.1.16, RHEA:17628] subset: gosubset_prok synonym: "2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16] synonym: "D(+)-lysopine dehydrogenase activity" EXACT [EC:1.5.1.16] synonym: "D-lysopine synthase activity" EXACT [EC:1.5.1.16] synonym: "lysopine dehydrogenase activity" EXACT [EC:1.5.1.16] synonym: "N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16] xref: EC:1.5.1.16 xref: KEGG:R00452 xref: MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN xref: RHEA:17628 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047828 name: D-lyxose ketol-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-lyxose = D-xylulose." [EC:5.3.1.15, RHEA:14204] synonym: "D-lyxose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.15] synonym: "D-lyxose isomerase activity" EXACT [EC:5.3.1.15] xref: EC:5.3.1.15 xref: KEGG:R01898 xref: MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN xref: RHEA:14204 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0047829 name: D-nopaline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH." [EC:1.5.1.19, MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19] synonym: "D-nopaline synthase activity" EXACT [EC:1.5.1.19] synonym: "N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19] synonym: "nopaline dehydrogenase activity" EXACT [EC:1.5.1.19] synonym: "nopaline synthase activity" EXACT [EC:1.5.1.19] synonym: "NOS activity" EXACT [EC:1.5.1.19] xref: EC:1.5.1.19 xref: MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047830 name: D-octopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH." [EC:1.5.1.11, MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11] synonym: "D-octopine synthase activity" EXACT [EC:1.5.1.11] synonym: "N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11] synonym: "octopine dehydrogenase activity" EXACT [EC:1.5.1.11] synonym: "octopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.11] synonym: "ODH activity" EXACT [EC:1.5.1.11] xref: EC:1.5.1.11 xref: MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047831 name: D-ornithine 4,5-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate." [EC:5.4.3.5, RHEA:14896] synonym: "D-alpha-ornithine 5,4-aminomutase activity" EXACT [EC:5.4.3.5] synonym: "D-ornithine aminomutase activity" EXACT [EC:5.4.3.5] xref: EC:5.4.3.5 xref: KEGG:R02461 xref: MetaCyc:ORNMUTST-RXN xref: RHEA:14896 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0047832 name: D-pinitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH." [EC:1.1.1.142, RHEA:20440] subset: gosubset_prok synonym: "1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142] synonym: "5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142] xref: EC:1.1.1.142 xref: KEGG:R03498 xref: MetaCyc:D-PINITOL-DEHYDROGENASE-RXN xref: RHEA:20440 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047833 name: D-sorbitol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor." [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN] synonym: "D-sorbitol dehydrogenase activity" EXACT [] synonym: "D-sorbitol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.21] synonym: "D-sorbitol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.21] xref: EC:1.1.99.21 xref: MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047834 name: D-threo-aldose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH." [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "(2S,3R)-aldose dehydrogenase activity" EXACT [EC:1.1.1.122] synonym: "D-threo-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.122] synonym: "dehydrogenase, L-fucose" EXACT [EC:1.1.1.122] synonym: "L-fucose (D-arabinose) dehydrogenase activity" EXACT [EC:1.1.1.122] synonym: "L-fucose dehydrogenase activity" EXACT [EC:1.1.1.122] xref: EC:1.1.1.122 xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047835 name: D-tryptophan N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H(+)." [EC:2.3.1.34, RHEA:10063] synonym: "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.34] synonym: "acetyl-CoA:D-tryptophan N-acetyltransferase activity" EXACT [EC:2.3.1.34] synonym: "D-tryptophan acetyltransferase activity" EXACT [EC:2.3.1.34] xref: EC:2.3.1.34 xref: KEGG:R02481 xref: MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN xref: RHEA:10063 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047836 name: D-tryptophan N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H(+)." [EC:2.3.1.112, RHEA:23323] synonym: "malonyl-CoA:D-tryptophan N-malonyltransferase activity" EXACT [EC:2.3.1.112] xref: EC:2.3.1.112 xref: KEGG:R02482 xref: MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN xref: RHEA:23323 is_a: GO:0050735 ! N-malonyltransferase activity [Term] id: GO:0047837 name: D-xylose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH." [EC:1.1.1.179, RHEA:22003] subset: gosubset_prok synonym: "D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.179] synonym: "D-xylose-NADP dehydrogenase activity" EXACT [EC:1.1.1.179] synonym: "D-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.179] synonym: "D-xylose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.179] xref: EC:1.1.1.179 xref: KEGG:R01430 xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN xref: RHEA:22003 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047838 name: D-xylose 1-dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH." [EC:1.1.1.175, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN] synonym: "(NAD)-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] synonym: "D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] synonym: "D-xylose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.175] synonym: "NAD-D-xylose" RELATED [EC:1.1.1.175] synonym: "NAD-D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] synonym: "NAD-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] xref: EC:1.1.1.175 xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047839 name: dATP(dGTP)-DNA purinetransferase activity namespace: molecular_function def: "Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA." [EC:2.6.99.1, MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN] synonym: "dATP(dGTP)--DNA purine transferase activity" EXACT [] synonym: "dATP(dGTP):depurinated-DNA purine transferase activity" EXACT [EC:2.6.99.1] xref: EC:2.6.99.1 xref: MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0047840 name: dCTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate." [EC:3.6.1.12, MetaCyc:DCTP-PYROPHOSPHATASE-RXN] synonym: "dCTP nucleotidohydrolase activity" EXACT [EC:3.6.1.12] synonym: "dCTP pyrophosphatase activity" EXACT [] synonym: "dCTPase activity" EXACT [EC:3.6.1.12] synonym: "deoxy-CTPase activity" EXACT [EC:3.6.1.12] synonym: "deoxycytidine triphosphatase activity" EXACT [EC:3.6.1.12] synonym: "deoxycytidine-triphosphatase activity" EXACT [EC:3.6.1.12] xref: EC:3.6.1.12 xref: MetaCyc:DCTP-PYROPHOSPHATASE-RXN is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0047841 name: dehydrogluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.13, RHEA:10791] synonym: "2-ketogluconate kinase activity" EXACT [EC:2.7.1.13] synonym: "2-ketogluconokinase activity" EXACT [EC:2.7.1.13] synonym: "ATP:2-dehydro-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.13] synonym: "dehydogluconokinase activity" EXACT [] synonym: "ketogluconokinase (phosphorylating)" EXACT [EC:2.7.1.13] synonym: "ketogluconokinase activity" EXACT [EC:2.7.1.13] xref: EC:2.7.1.13 xref: KEGG:R02658 xref: MetaCyc:DEHYDOGLUCONOKINASE-RXN xref: RHEA:10791 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047842 name: dehydro-L-gulonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydro-L-gulonate + H(+) = L-xylulose + CO(2)." [EC:4.1.1.34, RHEA:11087] synonym: "3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)" EXACT [EC:4.1.1.34] synonym: "3-dehydro-L-gulonate carboxy-lyase activity" EXACT [EC:4.1.1.34] synonym: "3-keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34] synonym: "keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34] xref: EC:4.1.1.34 xref: KEGG:R01905 xref: MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN xref: RHEA:11087 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047843 name: dehydrogluconate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2)." [EC:1.1.99.4, RHEA:12371] synonym: "2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.4] synonym: "2-keto-D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.4] synonym: "2-oxogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] synonym: "alpha-ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] synonym: "ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] xref: EC:1.1.99.4 xref: KEGG:R07153 xref: MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN xref: RHEA:12371 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047844 name: deoxycytidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3." [EC:3.5.4.14, MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN] subset: gosubset_prok synonym: "deoxycytidine aminohydrolase activity" EXACT [EC:3.5.4.14] xref: EC:3.5.4.14 xref: MetaCyc:CYTIDEAM-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047845 name: deoxylimonate A-ring-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: deoxylimonoate + H(2)O = deoxylimononate D-ring-lactone + H(+)." [EC:3.1.1.46, RHEA:15000] synonym: "deoxylimonate A-ring-lactonohydrolase activity" EXACT [EC:3.1.1.46] xref: EC:3.1.1.46 xref: KEGG:R03803 xref: MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN xref: RHEA:15000 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047846 name: deoxynucleotide 3'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate." [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN] synonym: "3'-deoxynucleotidase activity" EXACT [EC:3.1.3.34] synonym: "3'-deoxyribonucleotidase activity" EXACT [EC:3.1.3.34] synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.34] xref: EC:3.1.3.34 xref: MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047847 name: deoxyuridine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate." [EC:2.4.2.23, MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN] synonym: "2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] synonym: "deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] synonym: "deoxyuridine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] xref: EC:2.4.2.23 xref: MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047848 name: dephospho-[reductase kinase] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]." [EC:2.7.11.3, MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN] synonym: "AMP-activated kinase activity" EXACT [EC:2.7.11.3] synonym: "AMP-activated protein kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity" EXACT [EC:2.7.11.3] synonym: "dephospho-reductase kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity" EXACT [EC:2.7.11.3] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "reductase kinase activity" BROAD [EC:2.7.11.3] synonym: "reductase kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "STK30" RELATED [EC:2.7.11.3] xref: EC:2.7.11.3 xref: MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0047849 name: dextransucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)." [EC:2.4.1.5, MetaCyc:DEXTRANSUCRASE-RXN] subset: gosubset_prok synonym: "CEP" RELATED [EC:2.4.1.5] synonym: "SGE" RELATED [EC:2.4.1.5] synonym: "sucrose 6-glucosyltransferase activity" EXACT [EC:2.4.1.5] synonym: "sucrose-1,6-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.5] synonym: "sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.5] xref: EC:2.4.1.5 xref: MetaCyc:DEXTRANSUCRASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047850 name: diaminopimelate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H(2)O + NADP(+) = L-2-amino-6-oxopimelate + H(+) + NADPH + NH(4)(+)." [EC:1.4.1.16, RHEA:13564] subset: gosubset_prok synonym: "meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.16] synonym: "meso-alpha,epsilon-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16] synonym: "meso-diaminopimelate D-dehydrogenase activity" EXACT [EC:1.4.1.16] synonym: "meso-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16] xref: EC:1.4.1.16 xref: KEGG:R02755 xref: MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN xref: RHEA:13564 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0047851 name: dicarboxylate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an omega-dicarboxylic acid = AMP + diphosphate + an omega-carboxyacyl-CoA." [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN] synonym: "carboxylyl-CoA synthetase activity" EXACT [EC:6.2.1.23] synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.23] xref: EC:6.2.1.23 xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047852 name: diferric-transferrin reductase activity namespace: molecular_function def: "Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH." [EC:1.16.1.2, MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN] synonym: "diferric transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "NADH diferric transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.2] xref: EC:1.16.1.2 xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0047853 name: difructose-anhydride synthase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose." [EC:3.2.1.134, MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN] synonym: "bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity" EXACT [EC:3.2.1.134] synonym: "inulobiose hydrolase activity" EXACT [EC:3.2.1.134] xref: EC:3.2.1.134 xref: MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047854 name: diguanidinobutanase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-diguanidinobutane + H(2)O = agmatine + urea." [EC:3.5.3.20, RHEA:13600] synonym: "1,4-diguanidinobutane amidinohydrolase activity" EXACT [EC:3.5.3.20] xref: EC:3.5.3.20 xref: KEGG:R01418 xref: MetaCyc:DIGUANIDINOBUTANASE-RXN xref: RHEA:13600 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047855 name: dihydrobunolol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH." [EC:1.1.1.160, RHEA:15928] synonym: "(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.160] synonym: "bunolol reductase activity" EXACT [EC:1.1.1.160] xref: EC:1.1.1.160 xref: KEGG:R04623 xref: MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN xref: RHEA:15928 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047856 name: dihydrocoumarin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H(2)O = 3-(2-hydroxyphenyl)propanoate + H(+)." [EC:3.1.1.35, RHEA:10363] subset: gosubset_prok synonym: "dihydrocoumarin lactonohydrolase activity" EXACT [EC:3.1.1.35] synonym: "dihydrocoumarin lipase activity" EXACT [] xref: EC:3.1.1.35 xref: KEGG:R03692 xref: MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN xref: RHEA:10363 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047857 name: dihydrouracil oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + O(2) = H(2)O(2) + uracil." [EC:1.3.3.7, RHEA:12387] synonym: "5,6-dihydrouracil:oxygen oxidoreductase activity" EXACT [EC:1.3.3.7] xref: EC:1.3.3.7 xref: KEGG:R00975 xref: MetaCyc:DIHYDROURACIL-OXIDASE-RXN xref: RHEA:12387 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0047858 name: dihydroxyfumarate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2)." [EC:4.1.1.54, RHEA:13848] synonym: "dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.54] synonym: "dihydroxyfumarate carboxy-lyase activity" EXACT [EC:4.1.1.54] xref: EC:4.1.1.54 xref: KEGG:R03127 xref: MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN xref: RHEA:13848 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047859 name: dihydroxyphenylalanine ammonia-lyase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine = trans-caffeate + NH3." [EC:4.3.1.11, MetaCyc:DIHYDROXYPHENYLALANINE-AMMONIA-LYASE-RXN] comment: This term was made obsolete because the corresponding EC reaction has been deleted from the EC. synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase (trans-caffeate-forming)" EXACT [EC:4.3.1.11] synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.11] synonym: "beta-(3,4-dihydroxyphenyl)-L-alanine (DOPA) ammonia-lyase activity" EXACT [EC:4.3.1.11] xref: EC:4.3.1.11 is_obsolete: true [Term] id: GO:0047860 name: diiodophenylpyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH." [EC:1.1.1.96, RHEA:20296] synonym: "2-oxo acid reductase activity" EXACT [EC:1.1.1.96] synonym: "3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.96] synonym: "aromatic alpha-keto acid" RELATED [EC:1.1.1.96] synonym: "KAR" RELATED [EC:1.1.1.96] xref: EC:1.1.1.96 xref: KEGG:R03431 xref: MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN xref: RHEA:20296 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047861 name: diiodotyrosine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate." [EC:2.6.1.24, RHEA:19784] synonym: "3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.24] synonym: "diiodotyrosine aminotransferase activity" EXACT [] synonym: "halogenated tyrosine aminotransferase activity" EXACT [EC:2.6.1.24] synonym: "halogenated tyrosine transaminase activity" EXACT [EC:2.6.1.24] xref: EC:2.6.1.24 xref: KEGG:R03207 xref: MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN xref: RHEA:19784 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047862 name: diisopropyl-fluorophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diisopropyl fluorophosphate + H(2)O = diisopropyl phosphate + 2 H(+) + hydrogen fluoride." [EC:3.1.8.2, RHEA:24103] synonym: "DFPase activity" EXACT [EC:3.1.8.2] synonym: "dialkylfluorophosphatase activity" EXACT [EC:3.1.8.2] synonym: "diisopropyl phosphorofluoridate hydrolase activity" EXACT [EC:3.1.8.2] synonym: "diisopropyl-fluorophosphate fluorohydrolase activity" EXACT [EC:3.1.8.2] synonym: "diisopropylfluorophosphonate dehalogenase activity" EXACT [EC:3.1.8.2] synonym: "diisopropylphosphofluoridase activity" EXACT [EC:3.1.8.2] synonym: "isopropylphosphorofluoridase activity" EXACT [EC:3.1.8.2] synonym: "OPA anhydrase activity" EXACT [EC:3.1.8.2] synonym: "OPAA activity" EXACT [EC:3.1.8.2] synonym: "organophosphate acid anhydrase activity" EXACT [EC:3.1.8.2] synonym: "organophosphorus acid anhydrolase activity" EXACT [EC:3.1.8.2] synonym: "somanase activity" EXACT [EC:3.1.8.2] synonym: "tabunase activity" EXACT [EC:3.1.8.2] xref: EC:3.1.8.2 xref: KEGG:R01533 xref: MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN xref: RHEA:24103 is_a: GO:0016795 ! phosphoric triester hydrolase activity [Term] id: GO:0047863 name: dimethylallylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate." [EC:2.5.1.28, RHEA:11331] synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity" EXACT [EC:2.5.1.28] synonym: "neryl-diphosphate synthase activity" EXACT [EC:2.5.1.28] xref: EC:2.5.1.28 xref: KEGG:R01659 xref: MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN xref: RHEA:11331 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0047864 name: dimethylaniline-N-oxide aldolase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde." [EC:4.1.2.24, RHEA:19324] subset: gosubset_prok synonym: "microsomal N-oxide dealkylase activity" EXACT [EC:4.1.2.24] synonym: "microsomal oxidase II" RELATED [EC:4.1.2.24] synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)" EXACT [EC:4.1.2.24] synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.24] xref: EC:4.1.2.24 xref: KEGG:R03345 xref: MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN xref: RHEA:19324 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047865 name: dimethylglycine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylglycine + A + H(2)O = AH(2) + formaldehyde + sarcosine." [EC:1.5.99.2, RHEA:22499] subset: gosubset_prok synonym: "N,N-dimethylglycine oxidase activity" EXACT [EC:1.5.99.2] synonym: "N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.2] synonym: "N,N-dimethylglycine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.2] xref: EC:1.5.99.2 xref: KEGG:R01565 xref: MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN xref: RHEA:22499 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0047866 name: dimethylglycine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylglycine + H(2)O + O(2) = formaldehyde + H(2)O(2) + sarcosine." [EC:1.5.3.10, RHEA:17080] synonym: "N,N-dimethylglycine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.10] xref: EC:1.5.3.10 xref: KEGG:R01564 xref: MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN xref: RHEA:17080 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0047867 name: dimethylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO(2) + NADH." [EC:1.1.1.84, RHEA:13324] synonym: "(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.84] synonym: "beta,beta-dimethylmalate dehydrogenase activity" EXACT [EC:1.1.1.84] xref: EC:1.1.1.84 xref: KEGG:R01211 xref: MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN xref: RHEA:13324 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047868 name: dimethylmaleate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H(2)O." [EC:4.2.1.85, RHEA:20256] synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)" EXACT [EC:4.2.1.85] synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase activity" EXACT [EC:4.2.1.85] xref: EC:4.2.1.85 xref: KEGG:R03069 xref: MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN xref: RHEA:20256 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047869 name: dimethylpropiothetin dethiomethylase activity namespace: molecular_function def: "Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)." [EC:4.4.1.3, RHEA:19968] synonym: "desulfhydrase activity" EXACT [EC:4.4.1.3] synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)" EXACT [EC:4.4.1.3] synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity" EXACT [EC:4.4.1.3] xref: EC:4.4.1.3 xref: KEGG:R02574 xref: MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN xref: RHEA:19968 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047870 name: discadenine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H(+)." [EC:2.5.1.24, RHEA:19584] synonym: "discadenine synthetase activity" EXACT [EC:2.5.1.24] synonym: "S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity" EXACT [EC:2.5.1.24] synonym: "S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas" RELATED [EC:2.5.1.24] xref: EC:2.5.1.24 xref: KEGG:R03726 xref: MetaCyc:DISCADENINE-SYNTHASE-RXN xref: RHEA:19584 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047871 name: disulfoglucosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H(2)O = N-sulfo-D-glucosamine + H(+) + sulfate." [EC:3.1.6.11, RHEA:15520] synonym: "6,N-disulfoglucosamine 6-O-sulfohydrolase activity" EXACT [EC:3.1.6.11] synonym: "disulphoglucosamine-6-sulphatase activity" EXACT [] synonym: "N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity" EXACT [EC:3.1.6.11] synonym: "N-sulfoglucosamine-6-sulfatase activity" EXACT [EC:3.1.6.11] xref: EC:3.1.6.11 xref: KEGG:R03216 xref: MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN xref: RHEA:15520 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0047872 name: dolichol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate." [EC:2.3.1.123, MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:dolichol acyltransferase activity" EXACT [EC:2.3.1.123] synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" EXACT [EC:2.3.1.123] xref: EC:2.3.1.123 xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047873 name: dolichyl-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate." [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN] synonym: "Dol-P phosphatase activity" EXACT [EC:3.1.3.51] synonym: "Dol-P-P phosphohydrolase activity" EXACT [] synonym: "dolichol monophosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichol phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichol phosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichyl monophosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichyl phosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichyl pyrophosphate phosphatase activity" EXACT [] synonym: "dolichyl-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.51] synonym: "polyisoprenyl phosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "polyprenylphosphate phosphatase activity" EXACT [EC:3.1.3.51] xref: EC:3.1.3.51 xref: MetaCyc:DOLICHYL-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047874 name: dolichyldiphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN] synonym: "dolichol diphosphatase activity" EXACT [EC:3.6.1.43] synonym: "dolichyl diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43] synonym: "dolichyl pyrophosphatase activity" EXACT [EC:3.6.1.43] synonym: "dolichyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43] xref: EC:3.6.1.43 xref: MetaCyc:DOLICHYLDIPHOSPHATASE-RXN xref: Reactome:79576 "dolichyldiphosphatase activity" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047875 name: ecdysone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: Ecdysone + O(2) = 3-dehydroecdysone + H(2)O(2)." [EC:1.1.3.16, RHEA:11799] synonym: "beta-ecdysone oxidase activity" EXACT [EC:1.1.3.16] synonym: "ecdysone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.16] xref: EC:1.1.3.16 xref: KEGG:R02373 xref: MetaCyc:ECDYSONE-OXIDASE-RXN xref: RHEA:11799 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047876 name: endoglycosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose." [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN] subset: gosubset_prok synonym: "EGCase activity" EXACT [EC:3.2.1.123] synonym: "endo-glucosylceramidase activity" EXACT [EC:3.2.1.123] synonym: "endoglycoceramidase activity" EXACT [EC:3.2.1.123] synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.123] synonym: "oligoglycosylglucosylceramide glycohydrolase activity" EXACT [EC:3.2.1.123] xref: EC:3.2.1.123 xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047877 name: ephedrine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH." [EC:1.5.1.18, RHEA:16292] synonym: "(-)-ephedrine:NAD+ 2-oxidoreductase activity" EXACT [EC:1.5.1.18] xref: EC:1.5.1.18 xref: KEGG:R03614 xref: MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN xref: RHEA:16292 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047878 name: erythritol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.27, RHEA:20711] subset: gosubset_prok synonym: "ATP:erythritol 4-phosphotransferase activity" EXACT [EC:2.7.1.27] synonym: "erythritol kinase (phosphorylating)" EXACT [EC:2.7.1.27] xref: EC:2.7.1.27 xref: KEGG:R02430 xref: MetaCyc:ERYTHRITOL-KINASE-RXN xref: RHEA:20711 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047879 name: erythronolide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B." [EC:2.3.1.94, MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN] subset: gosubset_prok synonym: "erythronolide condensing enzyme activity" EXACT [EC:2.3.1.94] synonym: "malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.94] xref: EC:2.3.1.94 xref: MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047880 name: erythrulose reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH." [EC:1.1.1.162, RHEA:18008] synonym: "D-erythrulose reductase activity" EXACT [EC:1.1.1.162] synonym: "erythritol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.162] xref: EC:1.1.1.162 xref: KEGG:R08573 xref: MetaCyc:ERYTHRULOSE-REDUCTASE-RXN xref: RHEA:18008 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047881 name: estradiol 17-alpha-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+." [EC:1.1.1.148, MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN] synonym: "17alpha-estradiol dehydrogenase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.148] synonym: "estradiol 17a-dehydrogenase activity" EXACT [] synonym: "estradiol 17alpha-dehydrogenase activity" EXACT [EC:1.1.1.148] synonym: "estradiol 17alpha-oxidoreductase activity" EXACT [EC:1.1.1.148] xref: EC:1.1.1.148 xref: MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047882 name: estradiol 6-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + estradiol-17beta + O(2) = 6beta-hydroxyestradiol-17beta + A + H(2)O." [EC:1.14.99.11, RHEA:19140] synonym: "estradiol 6-beta-hydroxylase activity" EXACT [EC:1.14.99.11] synonym: "estradiol 6b-hydroxylase activity" EXACT [] synonym: "estradiol 6b-monooxygenase activity" EXACT [] synonym: "estradiol 6beta-hydroxylase activity" EXACT [EC:1.14.99.11] synonym: "estradiol 6beta-monooxygenase activity" EXACT [EC:1.14.99.11] synonym: "estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)" EXACT [EC:1.14.99.11] xref: EC:1.14.99.11 xref: KEGG:R03086 xref: MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN xref: RHEA:19140 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047883 name: ethanolamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2." [EC:1.4.3.8, MetaCyc:ETHANOLAMINE-OXIDASE-RXN] synonym: "ethanolamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.8] xref: EC:1.4.3.8 xref: MetaCyc:ETHANOLAMINE-OXIDASE-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0047884 name: FAD diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: FAD + H2O = AMP + FMN." [EC:3.6.1.18, MetaCyc:FAD-PYROPHOSPHATASE-RXN] synonym: "FAD nucleotidohydrolase activity" EXACT [EC:3.6.1.18] synonym: "FAD pyrophosphatase activity" EXACT [] synonym: "FAD pyrophosphohydrolase activity" EXACT [GOC:tb] synonym: "flavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] synonym: "flavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] synonym: "riboflavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] synonym: "riboflavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] xref: EC:3.6.1.18 xref: MetaCyc:FAD-PYROPHOSPHATASE-RXN is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0047885 name: farnesol 2-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol." [EC:5.2.1.9, RHEA:13404] subset: gosubset_prok synonym: "2-trans,6-trans-farnesol 2-cis-trans-isomerase activity" EXACT [EC:5.2.1.9] synonym: "farnesol isomerase activity" EXACT [EC:5.2.1.9] xref: EC:5.2.1.9 xref: KEGG:R03265 xref: MetaCyc:FARNESOL-2-ISOMERASE-RXN xref: RHEA:13404 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0047886 name: farnesol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14700] synonym: "2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.216] synonym: "farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.216] synonym: "NADP-farnesol dehydrogenase activity" EXACT [EC:1.1.1.216] xref: EC:1.1.1.216 xref: KEGG:R03264 xref: MetaCyc:FARNESOL-DEHYDROGENASE-RXN xref: RHEA:14700 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047887 name: farnesyl diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP." [EC:2.7.4.18, RHEA:21547] synonym: "ATP:farnesyl-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.18] synonym: "farnesyl pyrophosphate kinase activity" EXACT [EC:2.7.4.18] synonym: "farnesyl-diphosphate kinase activity" EXACT [] xref: EC:2.7.4.18 xref: KEGG:R02303 xref: MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN xref: RHEA:21547 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047888 name: fatty acid peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H(2)O(2) + H(+) + palmitate = CO(2) + 3 H(2)O + pentadecanal." [EC:1.11.1.3, RHEA:23963] synonym: "fatty-acid peroxidase activity" EXACT [] synonym: "hexadecanoate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.3] synonym: "long chain fatty acid peroxidase activity" EXACT [EC:1.11.1.3] xref: EC:1.11.1.3 xref: KEGG:R01703 xref: MetaCyc:FATTY-ACID-PEROXIDASE-RXN xref: RHEA:23963 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0047889 name: ferredoxin-nitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin." [EC:1.7.7.2, MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN] synonym: "assimilatory ferredoxin-nitrate reductase activity" EXACT [EC:1.7.7.2] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.7.2] synonym: "nitrate (ferredoxin) reductase activity" EXACT [EC:1.7.7.2] synonym: "nitrite:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.2] xref: EC:1.7.7.2 xref: MetaCyc:1.7.7.2-RXN is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor [Term] id: GO:0047890 name: flavanone 4-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH." [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN] synonym: "(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.234] synonym: "flavonone 4-reductase activity" EXACT [] xref: EC:1.1.1.234 xref: MetaCyc:FLAVANONE-4-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047891 name: flavone 7-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone." [EC:2.4.1.81, MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "flavone 7-O-b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDP-glucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDPglucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDPglucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "uridine diphosphoglucose-luteolin glucosyltransferase activity" EXACT [EC:2.4.1.81] xref: EC:2.4.1.81 xref: MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047892 name: flavone apiosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone." [EC:2.4.2.25, MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN] synonym: "UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity" EXACT [EC:2.4.2.25] synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25] synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25] xref: EC:2.4.2.25 xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047893 name: flavonol 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside." [EC:2.4.1.91, MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN] synonym: "GTI" RELATED [EC:2.4.1.91] synonym: "UDP-glucose flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDP-glucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDP-glucose:flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDPG:flavonoid-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDPglucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] xref: EC:2.4.1.91 xref: MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047894 name: flavonol 3-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate." [EC:2.8.2.25, RHEA:13456] synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT systematic_synonym [EC:2.8.2.25] synonym: "flavonol 3-sulphotransferase activity" EXACT [] xref: EC:2.8.2.25 xref: KEGG:R02159 xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN xref: RHEA:13456 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047895 name: formaldehyde dismutase activity namespace: molecular_function def: "Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate." [EC:1.2.99.4, MetaCyc:FORMALDEHYDE-DISMUTASE-RXN] synonym: "aldehyde dismutase activity" EXACT [EC:1.2.99.4] synonym: "cannizzanase activity" EXACT [EC:1.2.99.4] synonym: "formaldehyde:formaldehyde oxidoreductase activity" EXACT [EC:1.2.99.4] xref: EC:1.2.99.4 xref: MetaCyc:FORMALDEHYDE-DISMUTASE-RXN is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0047896 name: formaldehyde transketolase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone." [EC:2.2.1.3, MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN] synonym: "D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity" EXACT [EC:2.2.1.3] synonym: "DHAS activity" EXACT [EC:2.2.1.3] synonym: "dihydroxyacetone synthase activity" EXACT [EC:2.2.1.3] synonym: "glycerone synthase activity" EXACT [EC:2.2.1.3] xref: EC:2.2.1.3 xref: MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0047897 name: formate-dihydrofolate ligase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H(+) + phosphate." [EC:6.3.4.17, RHEA:24331] synonym: "dihydrofolate formyltransferase activity" EXACT [EC:6.3.4.17] synonym: "formate:dihydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.17] synonym: "formyl dihydrofolate synthase activity" EXACT [EC:6.3.4.17] xref: EC:6.3.4.17 xref: KEGG:R02238 xref: MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN xref: RHEA:24331 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0047898 name: formate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1." [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN] synonym: "formate:cytochrome b1 oxidoreductase activity" EXACT [EC:1.2.2.1] synonym: "formate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.1] xref: EC:1.2.2.1 xref: MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0047899 name: formate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: formate + NADP(+) = CO(2) + NADPH." [EC:1.2.1.43, RHEA:12003] subset: gosubset_prok synonym: "formate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.43] synonym: "NADP-dependent formate dehydrogenase activity" EXACT [EC:1.2.1.43] xref: EC:1.2.1.43 xref: KEGG:R00134 xref: MetaCyc:FORMATE-DEHYDROGENASE-NADP+-RXN xref: RHEA:12003 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047900 name: formate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H(+)." [EC:2.7.2.6, RHEA:16012] synonym: "ATP:formate phosphotransferase activity" EXACT [EC:2.7.2.6] xref: EC:2.7.2.6 xref: KEGG:R00518 xref: MetaCyc:FORMATE-KINASE-RXN xref: RHEA:16012 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047901 name: formyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: formyl-CoA + H(2)O = CoA + formate + H(+)." [EC:3.1.2.10, RHEA:19744] synonym: "formyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.10] xref: EC:3.1.2.10 xref: KEGG:R00521 xref: MetaCyc:FORMYL-COA-HYDROLASE-RXN xref: RHEA:19744 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047902 name: formylaspartate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate." [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN] synonym: "formylaspartic formylase (formylase I, formylase II)" EXACT [EC:3.5.1.8] synonym: "N-formyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.8] xref: EC:3.5.1.8 xref: MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047903 name: fructose 5-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN] subset: gosubset_prok synonym: "5-keto-D-fructose reductase (NADP+)" EXACT [EC:1.1.1.124] synonym: "5-ketofructose reductase (NADP(+)) activity" EXACT [EC:1.1.1.124] synonym: "5-ketofructose reductase (NADP)" EXACT [EC:1.1.1.124] synonym: "5-ketofructose reductase (NADP+) activity" EXACT [EC:1.1.1.124] synonym: "D-(-)fructose:(NADP+) 5-oxidoreductase activity" EXACT [EC:1.1.1.124] synonym: "D-fructose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.124] synonym: "fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.124] xref: EC:1.1.1.124 xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047904 name: fructose 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.11, RHEA:22307] synonym: "D-fructose dehydrogenase activity" EXACT [EC:1.1.99.11] synonym: "D-fructose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.11] synonym: "D-fructose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.11] synonym: "fructose 5-dehydrogenase (acceptor)" EXACT [EC:1.1.99.11] xref: EC:1.1.99.11 xref: KEGG:R00873 xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN xref: RHEA:22307 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047905 name: fructose-6-phosphate phosphoketolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O." [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN] subset: gosubset_prok synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.22] synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.22] xref: EC:4.1.2.22 xref: MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047906 name: fucosterol-epoxide lyase activity namespace: molecular_function def: "Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol." [EC:4.1.2.33, RHEA:10887] synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)" EXACT [EC:4.1.2.33] synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity" EXACT [EC:4.1.2.33] xref: EC:4.1.2.33 xref: KEGG:R03723 xref: MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN xref: RHEA:10887 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047907 name: furylfuramide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide." [EC:5.2.1.6, RHEA:21851] synonym: "2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity" EXACT [EC:5.2.1.6] xref: EC:5.2.1.6 xref: KEGG:R04538 xref: MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN xref: RHEA:21851 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0047908 name: fusarinine-C ornithinesterase activity namespace: molecular_function def: "Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol." [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN] synonym: "5-N-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48] synonym: "N5-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48] synonym: "ornithine esterase activity" EXACT [EC:3.1.1.48] xref: EC:3.1.1.48 xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047909 name: galactolipid O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol." [EC:2.3.1.134, MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN] synonym: "galactolipid:galactolipid acyltransferase activity" EXACT [EC:2.3.1.134] synonym: "mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.134] xref: EC:2.3.1.134 xref: MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047910 name: galactose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH." [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN] synonym: "D-galactose dehydrogenase (NADP+)" EXACT [EC:1.1.1.120] synonym: "D-galactose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.120] xref: EC:1.1.1.120 xref: MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047911 name: galacturan 1,4-alpha-galacturonidase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-galacturonide(n) + H2O = 1,4-alpha-D-galacturonide(n-1) + D-galacturonate." [EC:3.2.1.67, MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN] synonym: "exo-D-galacturonanase activity" EXACT [EC:3.2.1.67] synonym: "exo-D-galacturonase activity" EXACT [] synonym: "exo-polygalacturonase activity" EXACT [] synonym: "exopoly-D-galacturonase activity" EXACT [] synonym: "exopolygalacturonase activity" EXACT [EC:3.2.1.67] synonym: "galacturan 1,4-a-galacturonidase activity" EXACT [] synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" EXACT [EC:3.2.1.67] synonym: "poly(galacturonate) hydrolase activity" EXACT [EC:3.2.1.67] xref: EC:3.2.1.67 xref: MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047912 name: galacturonokinase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H(+)." [EC:2.7.1.44, RHEA:12968] synonym: "ATP:D-galacturonate 1-phosphotransferase activity" EXACT [EC:2.7.1.44] synonym: "galacturonokinase (phosphorylating) D-galacturonic acid kinase activity" EXACT [EC:2.7.1.44] xref: EC:2.7.1.44 xref: KEGG:R01980 xref: MetaCyc:GALACTURONOKINASE-RXN xref: RHEA:12968 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047913 name: gallate 1-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP." [EC:2.4.1.136, RHEA:15252] synonym: "gallate 1-b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDP-glucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose:gallate glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose:vanillate 1-O-glucosyltransferase activity" EXACT [EC:2.4.1.136] xref: EC:2.4.1.136 xref: KEGG:R03297 xref: MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:15252 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047914 name: gamma-glutamylhistamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown." [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN] synonym: "g-glutamylhistamine synthase activity" EXACT [] synonym: "gamma-GHA synthetase activity" EXACT [EC:6.3.2.18] synonym: "gamma-glutaminylhistamine synthetase activity" EXACT [EC:6.3.2.18] synonym: "L-glutamate:histamine ligase activity" EXACT [EC:6.3.2.18] xref: EC:6.3.2.18 xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047915 name: ganglioside galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN] synonym: "GM1-synthase activity" EXACT [EC:2.4.1.62] synonym: "UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose-GM2 ganglioside galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDPgalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "uridine diphosphate D-galactose:glycolipid galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "uridine diphosphogalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "uridine diphosphogalactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62] xref: EC:2.4.1.62 xref: MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047916 name: GDP-6-deoxy-D-talose 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+." [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN] synonym: "GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.135] synonym: "guanosine diphospho-6-deoxy-D-talose dehydrogenase activity" EXACT [EC:1.1.1.135] xref: EC:1.1.1.135 xref: MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047917 name: GDP-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-glucose + H(2)O = D-glucose + GDP + H(+)." [EC:3.2.1.42, RHEA:15052] synonym: "GDP-glucose glucohydrolase activity" EXACT [EC:3.2.1.42] synonym: "GDPglucose glucohydrolase activity" EXACT [EC:3.2.1.42] synonym: "GDPglucosidase activity" EXACT [EC:3.2.1.42] synonym: "guanosine diphosphate D-glucose glucohydrolase activity" EXACT [EC:3.2.1.42] synonym: "guanosine diphosphoglucosidase activity" EXACT [EC:3.2.1.42] xref: EC:3.2.1.42 xref: KEGG:R00337 xref: MetaCyc:GDP-GLUCOSIDASE-RXN xref: RHEA:15052 is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0047918 name: GDP-mannose 3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose = GDP-L-galactose." [EC:5.1.3.18] synonym: "GDP-D-mannose:GDP-L-galactose epimerase activity" EXACT [EC:5.1.3.18] synonym: "GDPmannose 3,5-epimerase activity" EXACT [EC:5.1.3.18] synonym: "guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity" EXACT [EC:5.1.3.18] xref: EC:5.1.3.18 xref: MetaCyc:RXN-1882 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047919 name: GDP-mannose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + H(2)O + 2 NAD(+) = GDP-D-mannuronate + 3 H(+) + 2 NADH." [EC:1.1.1.132, RHEA:21731] subset: gosubset_prok synonym: "GDP mannose dehydrogenase activity" EXACT [EC:1.1.1.132] synonym: "GDP-D-mannose:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.132] synonym: "GDPmannose 6-dehydrogenase activity" EXACT [EC:1.1.1.132] synonym: "guanosine diphospho-D-mannose dehydrogenase activity" EXACT [EC:1.1.1.132] synonym: "guanosine diphosphomannose dehydrogenase activity" EXACT [EC:1.1.1.132] xref: EC:1.1.1.132 xref: KEGG:R00880 xref: MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN xref: RHEA:21731 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047920 name: geissoschizine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + H(+) + NADPH." [EC:1.3.1.36, RHEA:11379] synonym: "geissoschizine:NADP+ 4,21-oxidoreductase activity" EXACT [EC:1.3.1.36] xref: EC:1.3.1.36 xref: KEGG:R03860 xref: MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN xref: RHEA:11379 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047921 name: aminoglycoside 2'-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H(+). This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.59, RHEA:24519] synonym: "acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] synonym: "acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] synonym: "gentamicin 2'-N-acetyltransferase activity" NARROW [] synonym: "gentamicin acetyltransferase II activity" NARROW [EC:2.3.1.59] synonym: "gentamycin 2'-N-acetyltransferase activity" NARROW [] synonym: "gentamycin acetyltransferase II" RELATED [EC:2.3.1.59] xref: EC:2.3.1.59 xref: KEGG:R03056 xref: MetaCyc:GENTAMICIN-2-N-ACETYLTRANSFERASE-RXN xref: RHEA:24519 is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity [Term] id: GO:0047922 name: gentisate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + O(2) = 3-maleylpyruvate + H(+)." [EC:1.13.11.4, RHEA:18240] subset: gosubset_prok synonym: "2,5-dihydroxybenzoate dioxygenase activity" EXACT [EC:1.13.11.4] synonym: "gentisate dioxygenase activity" EXACT [EC:1.13.11.4] synonym: "gentisate oxygenase activity" EXACT [EC:1.13.11.4] synonym: "gentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.4] synonym: "gentisic acid oxidase activity" EXACT [EC:1.13.11.4] xref: EC:1.13.11.4 xref: KEGG:R02656 xref: MetaCyc:GENTISATE-12-DIOXYGENASE-RXN xref: RHEA:18240 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047923 name: gentisate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + H(+) = CO(2) + hydroquinone." [EC:4.1.1.62, RHEA:21315] synonym: "2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)" EXACT [EC:4.1.1.62] synonym: "2,5-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.62] synonym: "gentisate carboxy-lyase activity" EXACT [EC:4.1.1.62] xref: EC:4.1.1.62 xref: KEGG:R02489 xref: MetaCyc:GENTISATE-DECARBOXYLASE-RXN xref: RHEA:21315 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047924 name: geraniol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH." [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN] synonym: "geraniol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.183] xref: EC:1.1.1.183 xref: MetaCyc:GERANIOL-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r1163 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047925 name: geranoyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.5, RHEA:17704] synonym: "geranoyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.5] synonym: "geranoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.5] synonym: "geranyl-CoA carboxylase activity" EXACT [EC:6.4.1.5] xref: EC:6.4.1.5 xref: KEGG:R03494 xref: MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN xref: RHEA:17704 xref: UM-BBD_reactionID:r1166 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0047926 name: geranyl-diphosphate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate." [EC:5.5.1.8, RHEA:18212] synonym: "(+)-bornyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.8] synonym: "(+)-bornylpyrophosphate cyclase activity" EXACT [EC:5.5.1.8] synonym: "bornyl diphosphate synthase activity" EXACT [EC:5.5.1.8] synonym: "bornyl pyrophosphate synthase activity" EXACT [EC:5.5.1.8] synonym: "bornyl pyrophosphate synthetase activity" EXACT [EC:5.5.1.8] xref: EC:5.5.1.8 xref: KEGG:R02007 xref: MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN xref: RHEA:18212 is_a: GO:0009975 ! cyclase activity is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0047927 name: gibberellin-44 dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2." [EC:1.14.11.12, MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN] synonym: "(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12] synonym: "(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12] synonym: "gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12] synonym: "oxygenase, gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12] xref: EC:1.14.11.12 xref: MetaCyc:RXN1F-168 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0047928 name: gibberellin beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside." [EC:2.4.1.176, MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "gibberellin b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176] synonym: "UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176] synonym: "uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.176] synonym: "uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity" EXACT [EC:2.4.1.176] xref: EC:2.4.1.176 xref: MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047929 name: gluconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.39, RHEA:21615] subset: gosubset_prok synonym: "D-gluconate dehydratase activity" EXACT [EC:4.2.1.39] synonym: "D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.39] synonym: "D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.39] xref: EC:4.2.1.39 xref: KEGG:R01538 xref: MetaCyc:GLUCONATE-DEHYDRATASE-RXN xref: RHEA:21615 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047930 name: glucosaminate ammonia-lyase activity namespace: molecular_function alt_id: GO:0050443 def: "Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3." [EC:4.3.1.9, MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN] comment: Note that this function was EC:4.3.1.21. synonym: "2-amino-2-deoxy-D-gluconate ammonia-lyase activity" EXACT [EC:4.3.1.9] synonym: "2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.9] synonym: "acetylenemonocarboxylic acid hydrase activity" EXACT [EC:4.3.1.9] synonym: "aminodeoxygluconate ammonia-lyase activity" EXACT [] synonym: "aminodeoxygluconate dehydratase activity" EXACT [] synonym: "D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.3.1.9] synonym: "D-glucosaminate ammonia-lyase activity" EXACT [EC:4.3.1.9] synonym: "D-glucosaminate dehydratase activity" EXACT [EC:4.3.1.9] synonym: "D-glucosaminic acid dehydrase activity" EXACT [EC:4.3.1.9] synonym: "glucosaminic dehydrase activity" EXACT [EC:4.3.1.9] xref: EC:4.3.1.9 xref: MetaCyc:4.3.1.21-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047931 name: glucosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate." [EC:2.7.1.8, MetaCyc:GLUCOSAMINE-KINASE-RXN] synonym: "aminodeoxyglucose kinase activity" EXACT [EC:2.7.1.8] synonym: "ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.8] synonym: "ATP:D-glucosamine phosphotransferase activity" EXACT [EC:2.7.1.8] synonym: "glucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.8] xref: EC:2.7.1.8 xref: MetaCyc:GLUCOSAMINE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047932 name: glucosamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H(+)." [EC:2.3.1.3, RHEA:21335] synonym: "acetyl-CoA:D-glucosamine N-acetyltransferase activity" EXACT [EC:2.3.1.3] synonym: "glucosamine acetylase activity" EXACT [EC:2.3.1.3] synonym: "glucosamine acetyltransferase activity" EXACT [EC:2.3.1.3] xref: EC:2.3.1.3 xref: KEGG:R01204 xref: MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN xref: RHEA:21335 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047933 name: glucose-1,6-bisphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H(+)." [EC:2.7.1.106, RHEA:16772] synonym: "3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106] synonym: "3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106] synonym: "glucose 1,6-diphosphate synthase activity" EXACT [EC:2.7.1.106] synonym: "glucose-1,6-bisphosphate synthetase activity" EXACT [EC:2.7.1.106] xref: EC:2.7.1.106 xref: KEGG:R01660 xref: MetaCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN xref: RHEA:16772 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047934 name: glucose 1-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH." [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN] synonym: "D-aldohexose dehydrogenase activity" EXACT [EC:1.1.1.118] synonym: "D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.118] synonym: "D-glucose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.118] xref: EC:1.1.1.118 xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047935 name: glucose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,4-lactone + NADPH." [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN] synonym: "D-glucose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.119] synonym: "NADP-dependent glucose dehydrogenase activity" EXACT [EC:1.1.1.119] synonym: "NADP-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119] synonym: "nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119] xref: EC:1.1.1.119 xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047936 name: glucose 1-dehydrogenase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47, MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "beta-D-glucose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.47] synonym: "D-glucose dehydrogenase (NAD(P))" EXACT [EC:1.1.1.47] synonym: "hexose phosphate dehydrogenase activity" EXACT [EC:1.1.1.47] xref: EC:1.1.1.47 xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047937 name: glucose-1-phosphate phosphodismutase activity namespace: molecular_function def: "Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate." [EC:2.7.1.41, MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN] subset: gosubset_prok synonym: "D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.41] synonym: "glucose 1-phosphate transphosphorylase activity" EXACT [EC:2.7.1.41] synonym: "phosphodismutase activity" EXACT [EC:2.7.1.41] xref: EC:2.7.1.41 xref: MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047938 name: glucose-6-phosphate 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN] synonym: "D-glucose-6-phosphate 1-epimerase activity" EXACT [EC:5.1.3.15] synonym: "glucose-6 phosphate 1-epimerase activity" EXACT [] xref: EC:5.1.3.15 xref: MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047939 name: L-glucuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH." [EC:1.1.1.19, RHEA:14912] synonym: "aldehyde reductase II activity" RELATED [EC:1.1.1.19] synonym: "D-glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19] synonym: "D-glucuronate reductase activity" NARROW [EC:1.1.1.19] synonym: "glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19] synonym: "glucuronate reductase activity" EXACT [] synonym: "NADP-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19] synonym: "TPN-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19] xref: EC:1.1.1.19 xref: KEGG:R01481 xref: MetaCyc:GLUCURONATE-REDUCTASE-RXN xref: RHEA:14912 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047940 name: glucuronokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H(+)." [EC:2.7.1.43, RHEA:17008] synonym: "ATP:D-glucuronate 1-phosphotransferase activity" EXACT [EC:2.7.1.43] synonym: "glucurono-glucuronokinase activity" EXACT [EC:2.7.1.43] synonym: "glucuronokinase (phosphorylating)" EXACT [EC:2.7.1.43] xref: EC:2.7.1.43 xref: KEGG:R01476 xref: MetaCyc:GLUCURONOKINASE-RXN xref: RHEA:17008 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047941 name: glucuronolactone reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH." [EC:1.1.1.20, RHEA:18928] subset: gosubset_prok xref: EC:1.1.1.20 xref: KEGG:R03183 xref: MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN xref: RHEA:18928 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047942 name: glutamate-ethylamine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.6, RHEA:20528] synonym: "L-glutamate:ethylamine ligase (ADP-forming)" EXACT [EC:6.3.1.6] synonym: "N(5)-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6] synonym: "N5-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6] synonym: "N5-ethylglutamine synthetase activity" EXACT [EC:6.3.1.6] synonym: "theanine synthetase activity" EXACT [EC:6.3.1.6] xref: EC:6.3.1.6 xref: KEGG:R02929 xref: MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN xref: RHEA:20528 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0047943 name: glutamate-methylamine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.4.12, RHEA:17120] synonym: "gamma-glutamylmethylamide synthetase activity" EXACT [EC:6.3.4.12] synonym: "L-glutamate:methylamine ligase (ADP-forming)" EXACT [EC:6.3.4.12] xref: EC:6.3.4.12 xref: KEGG:R01585 xref: MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN xref: RHEA:17120 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0047944 name: glutamate 1-kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP = alpha-L-glutamyl phosphate + ADP + H(+)." [EC:2.7.2.13, RHEA:17220] synonym: "ATP:L-glutamate 1-phosphotransferase activity" EXACT [EC:2.7.2.13] xref: EC:2.7.2.13 xref: KEGG:R00241 xref: MetaCyc:GLUTAMATE-1-KINASE-RXN xref: RHEA:17220 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047945 name: L-glutamine:pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine." [EC:2.6.1.15, RHEA:10403] subset: gosubset_prok synonym: "gamma-glutaminyltransferase activity" RELATED [EC:2.6.1.15] synonym: "glutaminase II activity" RELATED [EC:2.6.1.15] synonym: "glutamine transaminase activity" BROAD [EC:2.6.1.15] synonym: "glutamine transaminase L activity" BROAD [EC:2.6.1.15] synonym: "glutamine--oxo-acid transaminase activity" BROAD [EC:2.6.1.15] synonym: "glutamine--pyruvate aminotransferase activity" BROAD [] synonym: "glutamine-alpha-keto acid transamidase activity" BROAD [EC:2.6.1.15] synonym: "glutamine-alpha-keto acid transaminase activity" BROAD [EC:2.6.1.15] synonym: "glutamine-keto acid aminotransferase activity" BROAD [EC:2.6.1.15] synonym: "glutamine-oxo acid aminotransferase activity" BROAD [EC:2.6.1.15] synonym: "glutamine-pyruvate transaminase activity" BROAD [EC:2.6.1.15] synonym: "L-glutamine transaminase L" RELATED [EC:2.6.1.15] xref: EC:2.6.1.15 xref: KEGG:R00576 xref: MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN xref: Reactome:79752 "L-glutamine:pyruvate aminotransferase activity" xref: RHEA:10403 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047946 name: glutamine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine." [EC:2.3.1.68, MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" EXACT [EC:2.3.1.68] xref: EC:2.3.1.68 xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0047947 name: glutamine N-phenylacetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine." [EC:2.3.1.14, MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN] synonym: "glutamine phenylacetyltransferase activity" EXACT [EC:2.3.1.14] synonym: "phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity" EXACT [EC:2.3.1.14] synonym: "phenylacetyl-CoA:L-glutamine N-acetyltransferase activity" EXACT [EC:2.3.1.14] xref: EC:2.3.1.14 xref: MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047948 name: glutarate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H(+) + phosphate." [EC:6.2.1.6, RHEA:14172] synonym: "glutarate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.6] synonym: "glutaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.6] synonym: "glutaryl-CoA synthetase activity" EXACT [EC:6.2.1.6] xref: EC:6.2.1.6 xref: KEGG:R02402 xref: MetaCyc:GLUTARATE--COA-LIGASE-RXN xref: RHEA:14172 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047949 name: glutarate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH." [EC:1.2.1.20, MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN] synonym: "glutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.20] synonym: "glutarate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.20] xref: EC:1.2.1.20 xref: MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047950 name: glutathione oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + O(2) = glutathione disulfide + H(2)O(2)." [EC:1.8.3.3, RHEA:24115] synonym: "glutathione:oxygen oxidoreductase activity" EXACT [EC:1.8.3.3] xref: EC:1.8.3.3 xref: KEGG:R00120 xref: MetaCyc:GLUTATHIONE-OXIDASE-RXN xref: RHEA:24115 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0047951 name: glutathione thiolesterase activity namespace: molecular_function def: "Catalysis of the reaction: S-acylglutathione + H(2)O = a carboxylate + glutathione + H(+)." [EC:3.1.2.7, RHEA:22711] synonym: "citryl-glutathione thioesterhydrolase activity" EXACT [EC:3.1.2.7] synonym: "glutathione thioesterase activity" EXACT [] synonym: "S-acylglutathione hydrolase activity" EXACT [EC:3.1.2.7] xref: EC:3.1.2.7 xref: KEGG:R00547 xref: MetaCyc:GLUTATHIONE-THIOESTERASE-RXN xref: RHEA:22711 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0047952 name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN] subset: gosubset_prok synonym: "glycerol 3-phosphate dehydrogenase (NAD(P)) activity" EXACT [EC:1.1.1.94] synonym: "glycerol 3-phosphate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.94] synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.1.1.94] synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT [] synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.94] synonym: "sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.94] xref: EC:1.1.1.94 xref: MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047953 name: glycerol 2-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NADP(+) = glycerone + H(+) + NADPH." [EC:1.1.1.156, RHEA:12756] synonym: "DHA oxidoreductase activity" EXACT [EC:1.1.1.156] synonym: "dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.156] synonym: "dihydroxyacetone reductase (NADPH)" EXACT [EC:1.1.1.156] synonym: "dihydroxyacetone reductase activity" EXACT [EC:1.1.1.156] synonym: "glycerol:NADP+ 2-oxidoreductase (glycerone-forming)" EXACT [EC:1.1.1.156] xref: EC:1.1.1.156 xref: KEGG:R01039 xref: MetaCyc:GLYCEROL-2-DEHYDROGENASE-NADP+-RXN xref: RHEA:12756 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047954 name: glycerol-2-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 2-phosphate + H(2)O = glycerol + phosphate." [EC:3.1.3.19, RHEA:13108] synonym: "2-glycerophosphatase activity" EXACT [EC:3.1.3.19] synonym: "beta-glycerophosphatase activity" EXACT [EC:3.1.3.19] synonym: "beta-glycerophosphate phosphatase activity" EXACT [EC:3.1.3.19] synonym: "glycerol-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.19] xref: EC:3.1.3.19 xref: KEGG:R01043 xref: MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN xref: RHEA:13108 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047955 name: glycerol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: A + glycerol = AH(2) + glycerone." [EC:1.1.99.22, RHEA:17496] synonym: "glycerol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.22] synonym: "glycerol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.22] xref: EC:1.1.99.22 xref: KEGG:R01045 xref: MetaCyc:GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN xref: RHEA:17496 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047956 name: glycerol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH." [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN] synonym: "glycerol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.72] xref: EC:1.1.1.72 xref: MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047957 name: 4'-methoxyisoflavone 2'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O." [EC:1.14.13.53, MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN] synonym: "formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.13.53] synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.53] xref: EC:1.14.13.53 xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047958 name: glycine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate." [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN] synonym: "glutamate-glyoxylate transaminase activity" EXACT [] synonym: "glutamic-glyoxylic transaminase activity" EXACT [EC:2.6.1.4] synonym: "glycine aminotransferase activity" BROAD [] synonym: "glycine transaminase activity" BROAD [EC:2.6.1.4] synonym: "glyoxylate-glutamate aminotransferase activity" EXACT [EC:2.6.1.4] synonym: "glyoxylate-glutamic transaminase activity" EXACT [EC:2.6.1.4] synonym: "L-glutamate:glyoxylate aminotransferase activity" EXACT [] xref: EC:2.6.1.4 xref: MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047959 name: glycine dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c." [EC:1.4.2.1, MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN] synonym: "glycine-cytochrome c reductase activity" EXACT [EC:1.4.2.1] synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" EXACT [EC:1.4.2.1] synonym: "reductase, glycine-cytochrome c" EXACT [EC:1.4.2.1] xref: EC:1.4.2.1 xref: MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0016640 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor [Term] id: GO:0047960 name: glycine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH." [EC:1.4.1.10, MetaCyc:GLYCINE-DEHYDROGENASE-RXN] synonym: "glycine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.10] xref: EC:1.4.1.10 xref: MetaCyc:GLYCINE-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0047961 name: glycine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine." [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.13] synonym: "glycine acyltransferase activity" EXACT [EC:2.3.1.13] synonym: "glycine-N-acylase activity" EXACT [EC:2.3.1.13] xref: EC:2.3.1.13 xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0047962 name: glycine N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)." [EC:2.3.1.71, RHEA:18496] synonym: "benzoyl CoA-amino acid N-acyltransferase activity" EXACT [EC:2.3.1.71] synonym: "benzoyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.71] synonym: "benzoyl-CoA:glycine N-benzoyltransferase activity" EXACT [EC:2.3.1.71] xref: EC:2.3.1.71 xref: KEGG:R02452 xref: MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN xref: Reactome:79786 "glycine N-benzoyltransferase activity" xref: RHEA:18496 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047963 name: glycine N-choloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate." [EC:2.3.1.65, MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN] synonym: "amino acid N-choloyltransferase activity" EXACT [EC:2.3.1.65] synonym: "BACAT activity" EXACT [EC:2.3.1.65] synonym: "BAT activity" EXACT [EC:2.3.1.65] synonym: "bile acid-CoA:amino acid N-acyltransferase activity" EXACT [EC:2.3.1.65] synonym: "choloyl-CoA:glycine N-choloyltransferase activity" EXACT [EC:2.3.1.65] synonym: "cholyl-CoA glycine-taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] synonym: "cholyl-CoA:taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] synonym: "glycine--taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] xref: EC:2.3.1.65 xref: MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047964 name: glyoxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN] subset: gosubset_prok synonym: "glycolate reductase activity" EXACT [] synonym: "glyoxylic acid reductase activity" EXACT [EC:1.1.1.26] synonym: "NADH-dependent glyoxylate reductase activity" EXACT [EC:1.1.1.26] xref: EC:1.1.1.26 xref: MetaCyc:GLYCOLATE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047965 name: glycoprotein O-fatty-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein." [EC:2.3.1.142, MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN] synonym: "fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity" EXACT [EC:2.3.1.142] synonym: "protein acyltransferase activity" EXACT [EC:2.3.1.142] xref: EC:2.3.1.142 xref: MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN is_a: GO:0016416 ! O-palmitoyltransferase activity [Term] id: GO:0047966 name: glycosulfatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-sulfate + H(2)O = D-glucose + H(+) + sulfate." [EC:3.1.6.3, RHEA:19148] synonym: "glucosulfatase activity" EXACT [EC:3.1.6.3] synonym: "glycosulphatase activity" EXACT [] synonym: "sugar-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.3] xref: EC:3.1.6.3 xref: KEGG:R00534 xref: MetaCyc:GLYCOSULFATASE-RXN xref: RHEA:19148 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0047967 name: glycyrrhizinate beta-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: glycyrrhizate + H(2)O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate." [EC:3.2.1.128, RHEA:17372] synonym: "glycyrrhizin beta-hydrolase activity" EXACT [EC:3.2.1.128] synonym: "glycyrrhizin hydrolase activity" EXACT [EC:3.2.1.128] synonym: "glycyrrhizinate b-glucuronidase activity" EXACT [] synonym: "glycyrrhizinate glucuronosylhydrolase activity" EXACT [EC:3.2.1.128] synonym: "glycyrrhizinic acid hydrolase activity" EXACT [EC:3.2.1.128] xref: EC:3.2.1.128 xref: KEGG:R03906 xref: MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN xref: RHEA:17372 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047968 name: glyoxylate dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA." [EC:1.2.1.17, RHEA:21027] synonym: "glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)" EXACT [EC:1.2.1.17] xref: EC:1.2.1.17 xref: KEGG:R00468 xref: MetaCyc:GLYOXYLATE-DEHYDROGENASE-ACYLATING-RXN xref: RHEA:21027 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047969 name: glyoxylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate." [EC:1.2.3.5, RHEA:14840] synonym: "glyoxylate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.5] xref: EC:1.2.3.5 xref: KEGG:R00466 xref: MetaCyc:GLYOXYLATE-OXIDASE-RXN xref: Reactome:79800 "glyoxylate oxidase activity" xref: RHEA:14840 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0047970 name: guanidinoacetase activity namespace: molecular_function def: "Catalysis of the reaction: guanidinoacetate + H(2)O = glycine + urea." [EC:3.5.3.2, RHEA:23271] synonym: "glycocyaminase activity" EXACT [EC:3.5.3.2] synonym: "guanidinoacetate amidinohydrolase activity" EXACT [EC:3.5.3.2] xref: EC:3.5.3.2 xref: KEGG:R00775 xref: MetaCyc:GUANIDINOACETASE-RXN xref: RHEA:23271 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047971 name: guanidinobutyrase activity namespace: molecular_function def: "Catalysis of the reaction: 4-guanidinobutanoate + H(2)O = 4-aminobutanoate + urea." [EC:3.5.3.7, RHEA:19504] subset: gosubset_prok synonym: "4-guanidinobutanoate amidinohydrolase activity" EXACT [EC:3.5.3.7] synonym: "4-guanidinobutyrate amidinobutyrase activity" EXACT [EC:3.5.3.7] synonym: "G-base activity" EXACT [EC:3.5.3.7] synonym: "gamma-guanidinobutyrate amidinohydrolase activity" EXACT [EC:3.5.3.7] synonym: "gamma-guanidobutyrase activity" EXACT [EC:3.5.3.7] synonym: "GBH" RELATED [EC:3.5.3.7] synonym: "guanidinobutyrate ureahydrolase activity" EXACT [EC:3.5.3.7] xref: EC:3.5.3.7 xref: KEGG:R01990 xref: MetaCyc:GUANIDINOBUTYRASE-RXN xref: RHEA:19504 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047972 name: guanidinopropionase activity namespace: molecular_function def: "Catalysis of the reaction: 3-guanidinopropanoate + H(2)O = beta-alanine + urea." [EC:3.5.3.17, RHEA:16032] synonym: "3-guanidinopropanoate amidinopropionase activity" EXACT [EC:3.5.3.17] synonym: "GPase activity" EXACT [EC:3.5.3.17] synonym: "GPH" RELATED [EC:3.5.3.17] xref: EC:3.5.3.17 xref: KEGG:R00913 xref: MetaCyc:GUANIDINOPROPIONASE-RXN xref: RHEA:16032 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047973 name: guanidinoacetate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H(+) + phosphoguanidinoacetate." [EC:2.7.3.1, RHEA:14148] synonym: "ATP:guanidinoacetate N-phosphotransferase activity" EXACT [EC:2.7.3.1] synonym: "glycocyamine kinase activity" EXACT [EC:2.7.3.1] synonym: "guanidoacetate kinase activity" EXACT [] xref: EC:2.7.3.1 xref: KEGG:R02575 xref: MetaCyc:GUANIDOACETATE-KINASE-RXN xref: RHEA:14148 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0047974 name: guanosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN] synonym: "guanosine aminase activity" EXACT [EC:3.5.4.15] synonym: "guanosine aminohydrolase activity" EXACT [EC:3.5.4.15] xref: EC:3.5.4.15 xref: MetaCyc:GUANOSINE-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047975 name: guanosine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate." [EC:2.4.2.15, MetaCyc:GUANPHOSPHOR-RXN] synonym: "guanosine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.15] synonym: "guanosine:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.15] xref: EC:2.4.2.15 xref: MetaCyc:GUANPHOSPHOR-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047976 name: hamamelose kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H(+)." [EC:2.7.1.102, RHEA:22799] synonym: "ATP/hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102] synonym: "ATP:D-hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102] synonym: "hamamelose kinase (phosphorylating)" EXACT [EC:2.7.1.102] synonym: "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)" EXACT [EC:2.7.1.102] xref: EC:2.7.1.102 xref: KEGG:R03766 xref: MetaCyc:HAMAMELOSE-KINASE-RXN xref: RHEA:22799 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047977 name: hepoxilin-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate." [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN] synonym: "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity" EXACT [EC:3.3.2.7] synonym: "hepoxilin A(3) hydrolase activity" RELATED [EC:3.3.2.7] synonym: "hepoxilin A3 hydrolase activity" EXACT [EC:3.3.2.7] synonym: "hepoxilin epoxide hydrolase activity" EXACT [EC:3.3.2.7] synonym: "hepoxylin hydrolase activity" RELATED [EC:3.3.2.7] xref: EC:3.3.2.7 xref: MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0047978 name: hexadecanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH." [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN] synonym: "hexadecanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.164] xref: EC:1.1.1.164 xref: MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047979 name: hexose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN] synonym: "D-hexose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.5] xref: EC:1.1.3.5 xref: MetaCyc:HEXOSE-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047980 name: hippurate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzoylglycine + H(2)O = benzoate + glycine." [EC:3.5.1.32, RHEA:10427] subset: gosubset_prok synonym: "benzoylglycine amidohydrolase activity" EXACT [EC:3.5.1.32] synonym: "hippuricase activity" EXACT [EC:3.5.1.32] synonym: "N-benzoylamino-acid amidohydrolase activity" EXACT [EC:3.5.1.32] xref: EC:3.5.1.32 xref: KEGG:R01424 xref: MetaCyc:HIPPURATE-HYDROLASE-RXN xref: RHEA:10427 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047981 name: histidine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H(+)." [EC:2.3.1.33, RHEA:24599] synonym: "acetyl-CoA:L-histidine N-acetyltransferase activity" EXACT [EC:2.3.1.33] synonym: "acetylhistidine synthetase activity" EXACT [EC:2.3.1.33] synonym: "histidine acetyltransferase activity" EXACT [EC:2.3.1.33] xref: EC:2.3.1.33 xref: KEGG:R01160 xref: MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN xref: RHEA:24599 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047982 name: homocysteine desulfhydrase activity namespace: molecular_function def: "Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate." [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN] synonym: "homocysteine desulfurase activity" EXACT [EC:4.4.1.2] synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating)" EXACT [EC:4.4.1.2] synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.2] xref: EC:4.4.1.2 xref: MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047983 name: homoglutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H(+) + phosphate." [EC:6.3.2.23, RHEA:17996] synonym: "beta-alanine specific hGSH synthetase activity" EXACT [EC:6.3.2.23] synonym: "gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.23] synonym: "homoglutathione synthetase activity" EXACT [EC:6.3.2.23] xref: EC:6.3.2.23 xref: KEGG:R02741 xref: MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN xref: RHEA:17996 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047985 name: hydrogen dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2 + NAD+ = H+ + NADH." [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.1.2] synonym: "H(2):NAD(+) oxidoreductase activity" EXACT [EC:1.12.1.2] synonym: "H2:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2] synonym: "hydrogen:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2] synonym: "hydrogenase activity" BROAD [EC:1.12.1.2] synonym: "NAD-linked hydrogenase activity" EXACT [EC:1.12.1.2] xref: EC:1.12.1.2 xref: MetaCyc:HYDROGEN-DEHYDROGENASE-RXN is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor [Term] id: GO:0047986 name: hydrogen-sulfide S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate." [EC:2.3.1.10, RHEA:16628] synonym: "acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity" EXACT [EC:2.3.1.10] synonym: "hydrogen-sulfide acetyltransferase activity" EXACT [EC:2.3.1.10] synonym: "hydrogen-sulphide S-acetyltransferase activity" EXACT [] xref: EC:2.3.1.10 xref: KEGG:R01850 xref: MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN xref: RHEA:16628 is_a: GO:0016418 ! S-acetyltransferase activity [Term] id: GO:0047987 name: hydroperoxide dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate = (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O." [EC:4.2.1.92, MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity" EXACT [EC:4.2.1.92] synonym: "HPI" RELATED [EC:4.2.1.92] synonym: "hydroperoxide isomerase activity" EXACT [EC:4.2.1.92] synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] xref: EC:4.2.1.92 xref: MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047988 name: hydroxyacid-oxoacid transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN] synonym: "(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity" EXACT [EC:1.1.99.24] synonym: "transhydrogenase, hydroxy acid-oxo acid" EXACT [EC:1.1.99.24] xref: EC:1.1.99.24 xref: MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN xref: Reactome:79838 "hydroxyacid-oxoacid transhydrogenase activity" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047989 name: hydroxybutyrate-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H(2)O = 2 (R)-3-hydroxybutanoate + H(+)." [EC:3.1.1.22, RHEA:10175] subset: gosubset_prok synonym: "(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity" EXACT [EC:3.1.1.22] synonym: "D-(-)-3-hydroxybutyrate-dimer hydrolase activity" EXACT [EC:3.1.1.22] xref: EC:3.1.1.22 xref: KEGG:R00048 xref: MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN xref: RHEA:10175 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047990 name: hydroxyglutamate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO(2)." [EC:4.1.1.16, RHEA:14076] synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)" EXACT [EC:4.1.1.16] synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.16] xref: EC:4.1.1.16 xref: KEGG:R04135 xref: MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN xref: RHEA:14076 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047991 name: hydroxylamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxylamine + O(2) = H(2)O + H(+) + nitrite." [EC:1.7.3.4, RHEA:19972] subset: gosubset_prok synonym: "HAO" RELATED [EC:1.7.3.4] synonym: "hydroxylamine oxidoreductase" BROAD [EC:1.7.3.4] synonym: "hydroxylamine:oxygen oxidoreductase activity" EXACT [EC:1.7.3.4] xref: EC:1.7.3.4 xref: KEGG:R00793 xref: MetaCyc:HAONITRO-RXN xref: RHEA:19972 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0047992 name: hydroxylysine kinase activity namespace: molecular_function def: "Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H(+)." [EC:2.7.1.81, RHEA:19052] synonym: "GTP:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81] synonym: "guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81] synonym: "hydroxylysine kinase (phosphorylating)" EXACT [EC:2.7.1.81] xref: EC:2.7.1.81 xref: KEGG:R03378 xref: MetaCyc:HYDROXYLYSINE-KINASE-RXN xref: RHEA:19052 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047993 name: hydroxymalonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate." [EC:1.1.1.167, RHEA:11287] synonym: "hydroxymalonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.167] xref: EC:1.1.1.167 xref: KEGG:R02969 xref: MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN xref: RHEA:11287 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047994 name: hydroxymethylglutaryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H(2)O = 3-hydroxy-3-methylglutarate + CoA + H(+)." [EC:3.1.2.5, RHEA:16308] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5] synonym: "3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5] synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5] synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5] synonym: "hydroxymethylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5] synonym: "hydroxymethylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5] xref: EC:3.1.2.5 xref: KEGG:R02083 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN xref: RHEA:16308 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047995 name: hydroxyphenylpyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN] synonym: "4-hydroxyphenyllactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.237] synonym: "HPRP" RELATED [EC:1.1.1.237] xref: EC:1.1.1.237 xref: MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047996 name: hydroxyphytanate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-2-hydroxyphytanate + O(2) = 2-oxophytanate + H(2)O(2)." [EC:1.1.3.27, RHEA:21683] synonym: "L-2-hydroxyphytanate:oxygen 2-oxidoreductase" BROAD [EC:1.1.3.27] xref: EC:1.1.3.27 xref: KEGG:R07151 xref: MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN xref: RHEA:21683 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047997 name: hydroxypyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypyruvate + H(+) = CO(2) + glycolaldehyde." [EC:4.1.1.40, RHEA:20564] synonym: "hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)" EXACT [EC:4.1.1.40] synonym: "hydroxypyruvate carboxy-lyase activity" EXACT [EC:4.1.1.40] xref: EC:4.1.1.40 xref: KEGG:R01393 xref: MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN xref: RHEA:20564 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047998 name: hyoscyamine (6S)-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O(2) = (6S)-6-hydroxyhyoscyamine + CO(2) + succinate." [EC:1.14.11.11, RHEA:12632] synonym: "hyoscyamine (6S)-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6-beta-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6beta-dioxygenase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6beta-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)" EXACT [EC:1.14.11.11] xref: EC:1.14.11.11 xref: KEGG:R03812 xref: MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN xref: RHEA:12632 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0047999 name: hyponitrite reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH." [EC:1.7.1.5, RHEA:19340] synonym: "hydroxylamine:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.5] synonym: "NADH2:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5] synonym: "NADH:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5] xref: EC:1.7.1.5 xref: KEGG:R00023 xref: MetaCyc:HYPONITRITE-REDUCTASE-RXN xref: RHEA:19340 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0048000 name: isoflavone 3'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O." [EC:1.14.13.52, MetaCyc:ISOFLAVONE-3'-HYDROXYLASE-RXN] synonym: "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.52] synonym: "isoflavone 3'-monooxygenase activity" EXACT [EC:1.14.13.52] xref: EC:1.14.13.52 xref: MetaCyc:RXN-3762 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0048001 name: erythrose-4-phosphate dehydrogenase activity namespace: molecular_function alt_id: GO:0033724 def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH." [EC:1.2.1.72, RHEA:12059] synonym: "D-erythrose 4-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.72] synonym: "E4P dehydrogenase activity" EXACT [EC:1.2.1.72] synonym: "E4PDH" EXACT [EC:1.2.1.72] synonym: "Epd dehydrogenase activity" EXACT [EC:1.2.1.72] synonym: "erythrose 4-phosphate dehydrogenase activity" EXACT [EC:1.2.1.72] synonym: "GapB" RELATED [EC:1.2.1.72] xref: EC:1.2.1.72 xref: KEGG:R01825 xref: MetaCyc:ERYTH4PDEHYDROG-RXN xref: RHEA:12059 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0048002 name: antigen processing and presentation of peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "antigen presentation, peptide antigen" EXACT [] synonym: "peptide antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0048003 name: antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] synonym: "antigen presentation, lipid antigen" EXACT [] synonym: "lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0048006 name: antigen processing and presentation, endogenous lipid antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] synonym: "antigen presentation, endogenous lipid antigen" EXACT [] synonym: "endogenous lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0048007 name: antigen processing and presentation, exogenous lipid antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] synonym: "antigen presentation, exogenous peptide antigen" EXACT [] synonym: "exogenous lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0048008 name: platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "PDGF receptor signaling pathway" EXACT [] synonym: "PDGF receptor signalling pathway" EXACT [] synonym: "PDGFR signaling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048009 name: insulin-like growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "IGF receptor signaling pathway" EXACT [] synonym: "IGF receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048010 name: vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "VEGF receptor signaling pathway" EXACT [] synonym: "VEGF receptor signalling pathway" EXACT [] synonym: "VEGFR signaling pathway" EXACT [] xref: Reactome:1253493 "VEGF ligand-receptor interactions" xref: Reactome:1253494 "Signaling by VEGF" xref: Reactome:1280432 "VEGF ligand-receptor interactions" xref: Reactome:1280433 "Signaling by VEGF" xref: Reactome:1299264 "VEGF ligand-receptor interactions" xref: Reactome:1299265 "Signaling by VEGF" xref: Reactome:1327010 "VEGF ligand-receptor interactions" xref: Reactome:1327011 "Signaling by VEGF" xref: Reactome:1353104 "VEGF ligand-receptor interactions" xref: Reactome:1353105 "Signaling by VEGF" xref: Reactome:1373293 "VEGF ligand-receptor interactions" xref: Reactome:1373294 "Signaling by VEGF" xref: Reactome:1393306 "VEGF ligand-receptor interactions" xref: Reactome:1393307 "Signaling by VEGF" xref: Reactome:1417804 "VEGF ligand-receptor interactions" xref: Reactome:1417805 "Signaling by VEGF" xref: Reactome:1450902 "VEGF ligand-receptor interactions" xref: Reactome:1450903 "Signaling by VEGF" xref: Reactome:194138 "Signaling by VEGF" xref: Reactome:194313 "VEGF ligand-receptor interactions" is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048011 name: nerve growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "nerve growth factor receptor signalling pathway" EXACT [] synonym: "NGF receptor signaling pathway" EXACT [] synonym: "NGF receptor signalling pathway" EXACT [] xref: Reactome:1253024 "Signalling by NGF" xref: Reactome:1253353 "TRKA activation by NGF" xref: Reactome:1253479 "p75 NTR receptor-mediated signalling" xref: Reactome:1253482 "NFG and proNGF binds to p75NTR" xref: Reactome:1279953 "Signalling by NGF" xref: Reactome:1280291 "TRKA activation by NGF" xref: Reactome:1280417 "p75 NTR receptor-mediated signalling" xref: Reactome:1280418 "NFG and proNGF binds to p75NTR" xref: Reactome:1298846 "Signalling by NGF" xref: Reactome:1299142 "TRKA activation by NGF" xref: Reactome:1299251 "p75 NTR receptor-mediated signalling" xref: Reactome:1299254 "NFG and proNGF binds to p75NTR" xref: Reactome:1326529 "Signalling by NGF" xref: Reactome:1326869 "TRKA activation by NGF" xref: Reactome:1326995 "p75 NTR receptor-mediated signalling" xref: Reactome:1326998 "NFG and proNGF binds to p75NTR" xref: Reactome:1352638 "Signalling by NGF" xref: Reactome:1352961 "TRKA activation by NGF" xref: Reactome:1353090 "p75 NTR receptor-mediated signalling" xref: Reactome:1353093 "NFG and proNGF binds to p75NTR" xref: Reactome:1372872 "Signalling by NGF" xref: Reactome:1373163 "TRKA activation by NGF" xref: Reactome:1373278 "p75 NTR receptor-mediated signalling" xref: Reactome:1373281 "NFG and proNGF binds to p75NTR" xref: Reactome:1392876 "Signalling by NGF" xref: Reactome:1393298 "p75 NTR receptor-mediated signalling" xref: Reactome:1417361 "Signalling by NGF" xref: Reactome:1417667 "TRKA activation by NGF" xref: Reactome:1417791 "p75 NTR receptor-mediated signalling" xref: Reactome:1417794 "NFG and proNGF binds to p75NTR" xref: Reactome:1450446 "Signalling by NGF" xref: Reactome:1450767 "TRKA activation by NGF" xref: Reactome:1450891 "p75 NTR receptor-mediated signalling" xref: Reactome:1450894 "NFG and proNGF binds to p75NTR" xref: Reactome:1470971 "Signalling by NGF" xref: Reactome:1471281 "p75 NTR receptor-mediated signalling" xref: Reactome:1483007 "Signalling by NGF" xref: Reactome:1483251 "p75 NTR receptor-mediated signalling" xref: Reactome:1496948 "Signalling by NGF" xref: Reactome:1496991 "p75 NTR receptor-mediated signalling" xref: Reactome:1514335 "Signalling by NGF" xref: Reactome:1514378 "p75 NTR receptor-mediated signalling" xref: Reactome:1520995 "Signalling by NGF" xref: Reactome:1526791 "Signalling by NGF" xref: Reactome:1526932 "p75 NTR receptor-mediated signalling" xref: Reactome:1532517 "Signalling by NGF" xref: Reactome:1532668 "p75 NTR receptor-mediated signalling" xref: Reactome:1539303 "Signalling by NGF" xref: Reactome:166520 "Signalling by NGF" xref: Reactome:187042 "TRKA activation by NGF" xref: Reactome:193704 "p75 NTR receptor-mediated signalling" xref: Reactome:205017 "NFG and proNGF binds to p75NTR" is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048012 name: hepatocyte growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "HGF receptor signaling pathway" EXACT [] synonym: "HGF receptor signalling pathway" EXACT [] synonym: "Met signaling pathway" NARROW [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048013 name: ephrin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin." [GOC:ceb] synonym: "Eph receptor signaling pathway" EXACT [] synonym: "Eph receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048014 name: Tie receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a Tie receptor binding to one of its physiological ligands (angiopoietins)." [GOC:ceb] synonym: "Tek receptor signaling" EXACT [] synonym: "Tie receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048015 name: phosphatidylinositol-mediated signaling namespace: biological_process def: "A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "inositol phospholipid-mediated signaling" BROAD [] synonym: "phosphatidylinositol-mediated signalling" EXACT [GOC:curators] synonym: "phosphoinositide-mediated signaling" EXACT [GOC:curators] synonym: "phosphoinositide-mediated signalling" EXACT [] xref: Reactome:1253511 "PI3K/AKT signalling" xref: Reactome:1280450 "PI3K/AKT signalling" xref: Reactome:1299284 "PI3K/AKT signalling" xref: Reactome:1327028 "PI3K/AKT signalling" xref: Reactome:1353122 "PI3K/AKT signalling" xref: Reactome:1373311 "PI3K/AKT signalling" xref: Reactome:1393324 "PI3K/AKT signalling" xref: Reactome:1417822 "PI3K/AKT signalling" xref: Reactome:1450920 "PI3K/AKT signalling" xref: Reactome:1471300 "PI3K/AKT signalling" xref: Reactome:1483273 "PI3K/AKT signalling" xref: Reactome:1496951 "PI3K/AKT signalling" xref: Reactome:1514338 "PI3K/AKT signalling" xref: Reactome:1521201 "PI3K/AKT signalling" xref: Reactome:1526954 "PI3K/AKT signalling" xref: Reactome:1532689 "PI3K/AKT signalling" xref: Reactome:198203 "PI3K/AKT signalling" is_a: GO:0048017 ! inositol lipid-mediated signaling [Term] id: GO:0048016 name: inositol phosphate-mediated signaling namespace: biological_process def: "A series of molecular signals in which a cell uses a water-soluble inositol phosphate to convert a signal into a response. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6)." [GOC:bf, GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11331907] synonym: "inositol phosphate-mediated signalling" EXACT [] is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0048017 name: inositol lipid-mediated signaling namespace: biological_process def: "A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids." [GOC:bf, GOC:ceb, PMID:16088939] synonym: "inositol lipid-mediated signalling" EXACT [] synonym: "inositol phospholipid-mediated signaling" NARROW [] is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0048018 name: receptor agonist activity namespace: molecular_function def: "Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "receptor ligand activity" BROAD [GOC:mtg_signaling] is_a: GO:0005102 ! receptor binding is_a: GO:0030546 ! receptor activator activity [Term] id: GO:0048019 name: receptor antagonist activity namespace: molecular_function def: "Interacts with receptors to reduce the action of another ligand, the agonist." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "receptor ligand activity" BROAD [GOC:mtg_signaling] is_a: GO:0005102 ! receptor binding is_a: GO:0030547 ! receptor inhibitor activity [Term] id: GO:0048020 name: CCR chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR chemokine receptor." [GOC:ai] synonym: "beta chemokine receptor binding" EXACT [] synonym: "beta chemokine receptor ligand" NARROW [] synonym: "CCR chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0048021 name: regulation of melanin biosynthetic process namespace: biological_process def: "Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] subset: gosubset_prok synonym: "regulation of melanin anabolism" EXACT [] synonym: "regulation of melanin biosynthesis" EXACT [] synonym: "regulation of melanin formation" EXACT [] synonym: "regulation of melanin synthesis" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process relationship: regulates GO:0042438 ! melanin biosynthetic process [Term] id: GO:0048022 name: negative regulation of melanin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] subset: gosubset_prok synonym: "down regulation of melanin biosynthetic process" EXACT [] synonym: "down-regulation of melanin biosynthetic process" EXACT [] synonym: "downregulation of melanin biosynthetic process" EXACT [] synonym: "inhibition of melanin biosynthetic process" NARROW [] synonym: "negative regulation of melanin anabolism" EXACT [] synonym: "negative regulation of melanin biosynthesis" EXACT [] synonym: "negative regulation of melanin formation" EXACT [] synonym: "negative regulation of melanin synthesis" EXACT [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0048021 ! regulation of melanin biosynthetic process relationship: negatively_regulates GO:0042438 ! melanin biosynthetic process [Term] id: GO:0048023 name: positive regulation of melanin biosynthetic process namespace: biological_process def: "Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] subset: gosubset_prok synonym: "activation of melanin biosynthetic process" NARROW [] synonym: "positive regulation of melanin anabolism" EXACT [] synonym: "positive regulation of melanin biosynthesis" EXACT [] synonym: "positive regulation of melanin formation" EXACT [] synonym: "positive regulation of melanin synthesis" EXACT [] synonym: "stimulation of melanin biosynthetic process" NARROW [] synonym: "up regulation of melanin biosynthetic process" EXACT [] synonym: "up-regulation of melanin biosynthetic process" EXACT [] synonym: "upregulation of melanin biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0048021 ! regulation of melanin biosynthetic process relationship: positively_regulates GO:0042438 ! melanin biosynthetic process [Term] id: GO:0048024 name: regulation of nuclear mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0035055 def: "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] synonym: "regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "regulation of pre-mRNA splicing" BROAD [] is_a: GO:0043484 ! regulation of RNA splicing is_a: GO:0050684 ! regulation of mRNA processing relationship: regulates GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0048025 name: negative regulation of nuclear mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0035056 def: "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] synonym: "down regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "down regulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "down-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "down-regulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "downregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "downregulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "inhibition of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "inhibition of nuclear mRNA splicing, via spliceosome" NARROW [] synonym: "negative regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "negative regulation of pre-mRNA splicing" BROAD [] is_a: GO:0033119 ! negative regulation of RNA splicing is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome is_a: GO:0050686 ! negative regulation of mRNA processing relationship: negatively_regulates GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0048026 name: positive regulation of nuclear mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0035057 def: "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] synonym: "activation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "activation of nuclear mRNA splicing, via spliceosome" NARROW [] synonym: "positive regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "positive regulation of pre-mRNA splicing" BROAD [] synonym: "stimulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "stimulation of nuclear mRNA splicing, via spliceosome" NARROW [] synonym: "up regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "up regulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "up-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "up-regulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "upregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "upregulation of nuclear mRNA splicing, via spliceosome" EXACT [] is_a: GO:0033120 ! positive regulation of RNA splicing is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome is_a: GO:0050685 ! positive regulation of mRNA processing relationship: positively_regulates GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0048027 name: mRNA 5'-UTR binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [GOC:jid] subset: gosubset_prok synonym: "mRNA 5' UTR binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0048028 name: galacturonan binding namespace: molecular_function def: "Interacting selectively and non-covalently with any simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins." [GOC:jid] subset: gosubset_prok synonym: "polygalacturonide binding" RELATED [] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0048029 name: monosaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [CHEBI:35381, GOC:jid] subset: gosubset_prok is_a: GO:0005529 ! sugar binding [Term] id: GO:0048030 name: disaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any disaccharide. Disaccharides are sugars composed of two monosaccharide units." [GOC:jid] is_a: GO:0005529 ! sugar binding [Term] id: GO:0048031 name: trisaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any trisaccharide. Trisaccharides are sugars composed of three monosaccharide units." [GOC:jid] is_a: GO:0005529 ! sugar binding [Term] id: GO:0048032 name: galacturonate binding namespace: molecular_function def: "Interacting selectively and non-covalently with any galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [CHEBI:33812, GOC:jid] synonym: "galacturonic acid binding" EXACT [] is_a: GO:0043168 ! anion binding is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0048033 name: heme o metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid] subset: gosubset_prok synonym: "haem o metabolic process" EXACT [] synonym: "haem o metabolism" EXACT [] synonym: "heme o metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0048034 name: heme O biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid] subset: gosubset_prok synonym: "haem O biosynthesis" EXACT [] synonym: "haem O biosynthetic process" EXACT [] synonym: "heme O anabolism" EXACT [] synonym: "heme O biosynthesis" EXACT [] synonym: "heme O formation" EXACT [] synonym: "heme O synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0048033 ! heme o metabolic process [Term] id: GO:0048035 name: heme o catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid] subset: gosubset_prok synonym: "haem o catabolic process" EXACT [] synonym: "haem o catabolism" EXACT [] synonym: "heme o breakdown" EXACT [] synonym: "heme o catabolism" EXACT [] synonym: "heme o degradation" EXACT [] is_a: GO:0042167 ! heme catabolic process is_a: GO:0048033 ! heme o metabolic process [Term] id: GO:0048036 name: central complex development namespace: biological_process def: "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] synonym: "central body development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0048037 name: cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0048038 name: quinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0048037 ! cofactor binding [Term] id: GO:0048039 name: ubiquinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jid, ISBN:0582227089] subset: gosubset_prok synonym: "coenzyme Q binding" EXACT [] synonym: "coenzyme Q6 binding" NARROW [] is_a: GO:0048038 ! quinone binding [Term] id: GO:0048040 name: UDP-glucuronate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose." [EC:4.1.1.35, RHEA:23919] synonym: "UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)" EXACT [EC:4.1.1.35] synonym: "UDP-D-glucuronate carboxy-lyase activity" EXACT [EC:4.1.1.35] synonym: "UDP-glucuronic acid decarboxylase activity" EXACT [] synonym: "UDPglucuronate decarboxylase activity" EXACT [EC:4.1.1.35] synonym: "uridine-diphosphoglucuronate decarboxylase activity" EXACT [EC:4.1.1.35] xref: EC:4.1.1.35 xref: KEGG:R01384 xref: MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN xref: RHEA:23919 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0048041 name: focal adhesion assembly namespace: biological_process def: "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah] synonym: "focal adhesion formation" RELATED [GOC:mah] is_a: GO:0007044 ! cell-substrate junction assembly relationship: part_of GO:0007160 ! cell-matrix adhesion [Term] id: GO:0048042 name: regulation of post-mating oviposition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766] synonym: "regulation of oviposition, post-mating" EXACT [GOC:dph, GOC:tb] is_a: GO:0046662 ! regulation of oviposition relationship: regulates GO:0060403 ! post-mating oviposition [Term] id: GO:0048045 name: trans-pentaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate." [EC:2.5.1.33, RHEA:22635] subset: gosubset_prok synonym: "all-trans-hexaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.33] synonym: "all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity" EXACT [EC:2.5.1.33] synonym: "hexaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.33] synonym: "hexaprenyl pyrophosphate synthetase activity" EXACT [] xref: EC:2.5.1.33 xref: KEGG:R05613 xref: MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN xref: RHEA:22635 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0048046 name: apoplast namespace: cellular_component def: "The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jid] xref: Wikipedia:Apoplast is_a: GO:0005576 ! extracellular region [Term] id: GO:0048047 name: mating behavior, sex discrimination namespace: biological_process def: "The actions or reactions of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, PMID:12486700] synonym: "mating behaviour, sex discrimination" EXACT [] is_a: GO:0007617 ! mating behavior [Term] id: GO:0048048 name: embryonic eye morphogenesis namespace: biological_process def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0048592 ! eye morphogenesis [Term] id: GO:0048050 name: post-embryonic eye morphogenesis namespace: biological_process alt_id: GO:0048051 def: "The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight." [GOC:jid, GOC:sensu] is_a: GO:0048563 ! post-embryonic organ morphogenesis is_a: GO:0048592 ! eye morphogenesis [Term] id: GO:0048052 name: R1/R6 cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0048053 name: R1/R6 development namespace: biological_process def: "The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0048052 ! R1/R6 cell differentiation [Term] id: GO:0048054 name: R2/R5 cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0048055 name: R2/R5 development namespace: biological_process def: "The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0048054 ! R2/R5 cell differentiation [Term] id: GO:0048056 name: R3/R4 cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0048057 name: R3/R4 development namespace: biological_process def: "The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0048056 ! R3/R4 cell differentiation [Term] id: GO:0048058 name: compound eye corneal lens development namespace: biological_process def: "The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048749 ! compound eye development [Term] id: GO:0048060 name: negative gravitaxis namespace: biological_process alt_id: GO:0048063 def: "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid] synonym: "negative geotactic behavior" EXACT [] synonym: "negative geotactic behaviour" EXACT [] synonym: "negative gravitactic behavior" EXACT [] synonym: "negative gravitactic behaviour" EXACT [] synonym: "negative taxis in response to gravity" EXACT [] synonym: "negative taxis in response to gravitytaxis in response to gravitational stimulus" EXACT [] is_a: GO:0042332 ! gravitaxis [Term] id: GO:0048061 name: positive gravitaxis namespace: biological_process alt_id: GO:0048064 def: "The directed movement of a motile cell or organism towards the source of gravity." [GOC:jid] synonym: "positive geotactic behavior" EXACT [] synonym: "positive geotactic behaviour" EXACT [] synonym: "positive gravitactic behavior" EXACT [] synonym: "positive gravitactic behaviour" EXACT [] synonym: "positive taxis in response to gravity" EXACT [] synonym: "positive taxis in response to gravitytaxis in response to gravitational stimulus" EXACT [] is_a: GO:0042332 ! gravitaxis [Term] id: GO:0048065 name: male courtship behavior, veined wing extension namespace: biological_process def: "The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] synonym: "male courtship behavior, wing extension" BROAD [] synonym: "male courtship behaviour, veined wing extension" EXACT [] synonym: "male courtship behaviour, wing extension" BROAD [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0048066 name: developmental pigmentation namespace: biological_process def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] subset: gosubset_prok synonym: "pigmentation during development" RELATED [] is_a: GO:0032502 ! developmental process is_a: GO:0043473 ! pigmentation [Term] id: GO:0048067 name: cuticle pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] is_a: GO:0048066 ! developmental pigmentation relationship: part_of GO:0042335 ! cuticle development [Term] id: GO:0048069 name: eye pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in the eye of an organism." [GOC:jid] xref: Wikipedia:Eye_color is_a: GO:0048066 ! developmental pigmentation [Term] id: GO:0048070 name: regulation of developmental pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb] is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0048066 ! developmental pigmentation [Term] id: GO:0048071 name: sex-specific pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048066 ! developmental pigmentation relationship: part_of GO:0007548 ! sex differentiation [Term] id: GO:0048072 name: compound eye pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in the compound eye." [GOC:jid] is_a: GO:0048069 ! eye pigmentation [Term] id: GO:0048073 name: regulation of eye pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid] is_a: GO:0048070 ! regulation of developmental pigmentation relationship: regulates GO:0048069 ! eye pigmentation [Term] id: GO:0048074 name: negative regulation of eye pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid] synonym: "down regulation of eye pigmentation" EXACT [] synonym: "down-regulation of eye pigmentation" EXACT [] synonym: "downregulation of eye pigmentation" EXACT [] synonym: "inhibition of eye pigmentation" NARROW [] is_a: GO:0048073 ! regulation of eye pigmentation is_a: GO:0048086 ! negative regulation of developmental pigmentation relationship: negatively_regulates GO:0048069 ! eye pigmentation [Term] id: GO:0048075 name: positive regulation of eye pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid] synonym: "activation of eye pigmentation" NARROW [] synonym: "stimulation of eye pigmentation" NARROW [] synonym: "up regulation of eye pigmentation" EXACT [] synonym: "up-regulation of eye pigmentation" EXACT [] synonym: "upregulation of eye pigmentation" EXACT [] is_a: GO:0048073 ! regulation of eye pigmentation is_a: GO:0048087 ! positive regulation of developmental pigmentation relationship: positively_regulates GO:0048069 ! eye pigmentation [Term] id: GO:0048076 name: regulation of compound eye pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] is_a: GO:0048073 ! regulation of eye pigmentation relationship: regulates GO:0048072 ! compound eye pigmentation [Term] id: GO:0048077 name: negative regulation of compound eye pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] synonym: "down regulation of eye pigmentation" BROAD [] synonym: "down-regulation of eye pigmentation" BROAD [] synonym: "downregulation of eye pigmentation" BROAD [] synonym: "inhibition of eye pigmentation" BROAD [] synonym: "negative regulation of eye pigmentation" BROAD [] is_a: GO:0048074 ! negative regulation of eye pigmentation is_a: GO:0048076 ! regulation of compound eye pigmentation relationship: negatively_regulates GO:0048072 ! compound eye pigmentation [Term] id: GO:0048078 name: positive regulation of compound eye pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] synonym: "activation of eye pigmentation" BROAD [] synonym: "positive regulation of eye pigmentation" BROAD [] synonym: "stimulation of eye pigmentation" BROAD [] synonym: "up regulation of eye pigmentation" BROAD [] synonym: "up-regulation of eye pigmentation" BROAD [] synonym: "upregulation of eye pigmentation" BROAD [] is_a: GO:0048075 ! positive regulation of eye pigmentation is_a: GO:0048076 ! regulation of compound eye pigmentation relationship: positively_regulates GO:0048072 ! compound eye pigmentation [Term] id: GO:0048079 name: regulation of cuticle pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0048067 ! cuticle pigmentation [Term] id: GO:0048080 name: negative regulation of cuticle pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] synonym: "down regulation of cuticle pigmentation" EXACT [] synonym: "down-regulation of cuticle pigmentation" EXACT [] synonym: "downregulation of cuticle pigmentation" EXACT [] synonym: "inhibition of cuticle pigmentation" NARROW [] is_a: GO:0048079 ! regulation of cuticle pigmentation is_a: GO:0048086 ! negative regulation of developmental pigmentation relationship: negatively_regulates GO:0048067 ! cuticle pigmentation [Term] id: GO:0048081 name: positive regulation of cuticle pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] synonym: "activation of cuticle pigmentation" NARROW [] synonym: "stimulation of cuticle pigmentation" NARROW [] synonym: "up regulation of cuticle pigmentation" EXACT [] synonym: "up-regulation of cuticle pigmentation" EXACT [] synonym: "upregulation of cuticle pigmentation" EXACT [] is_a: GO:0048079 ! regulation of cuticle pigmentation is_a: GO:0048087 ! positive regulation of developmental pigmentation relationship: positively_regulates GO:0048067 ! cuticle pigmentation [Term] id: GO:0048082 name: regulation of adult chitin-containing cuticle pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] is_a: GO:0007564 ! regulation of chitin-based cuticle tanning is_a: GO:0048079 ! regulation of cuticle pigmentation relationship: regulates GO:0048085 ! adult chitin-containing cuticle pigmentation [Term] id: GO:0048083 name: negative regulation of adult chitin-containing cuticle pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] synonym: "down regulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "down-regulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "downregulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "inhibition of adult chitin-containing cuticle pigmentation" NARROW [] is_a: GO:0048080 ! negative regulation of cuticle pigmentation is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation relationship: negatively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation [Term] id: GO:0048084 name: positive regulation of adult chitin-containing cuticle pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] synonym: "activation of adult chitin-containing cuticle pigmentation" NARROW [] synonym: "stimulation of adult chitin-containing cuticle pigmentation" NARROW [] synonym: "up regulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "up-regulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "upregulation of adult chitin-containing cuticle pigmentation" EXACT [] is_a: GO:0048081 ! positive regulation of cuticle pigmentation is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation relationship: positively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation [Term] id: GO:0048085 name: adult chitin-containing cuticle pigmentation namespace: biological_process alt_id: GO:0048068 def: "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] synonym: "adult cuticle pigmentation" BROAD [] is_a: GO:0048067 ! cuticle pigmentation relationship: part_of GO:0007593 ! chitin-based cuticle tanning [Term] id: GO:0048086 name: negative regulation of developmental pigmentation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of pigmentation" NARROW [] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0048066 ! developmental pigmentation [Term] id: GO:0048087 name: positive regulation of developmental pigmentation namespace: biological_process def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph] synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, goc:tb] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0048066 ! developmental pigmentation [Term] id: GO:0048088 name: regulation of male pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0048094 ! male pigmentation [Term] id: GO:0048089 name: regulation of female pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0048095 ! female pigmentation [Term] id: GO:0048090 name: negative regulation of female pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid] synonym: "down regulation of female pigmentation" EXACT [] synonym: "down-regulation of female pigmentation" EXACT [] synonym: "downregulation of female pigmentation" EXACT [] synonym: "inhibition of female pigmentation" NARROW [] is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0048089 ! regulation of female pigmentation is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0048095 ! female pigmentation [Term] id: GO:0048091 name: positive regulation of female pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid] synonym: "activation of female pigmentation" NARROW [] synonym: "stimulation of female pigmentation" NARROW [] synonym: "up regulation of female pigmentation" EXACT [] synonym: "up-regulation of female pigmentation" EXACT [] synonym: "upregulation of female pigmentation" EXACT [] is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0048089 ! regulation of female pigmentation is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0048095 ! female pigmentation [Term] id: GO:0048092 name: negative regulation of male pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] synonym: "down regulation of male pigmentation" EXACT [] synonym: "down-regulation of male pigmentation" EXACT [] synonym: "downregulation of male pigmentation" EXACT [] synonym: "inhibition of male pigmentation" NARROW [] is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0048088 ! regulation of male pigmentation is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0048094 ! male pigmentation [Term] id: GO:0048093 name: positive regulation of male pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] synonym: "activation of male pigmentation" NARROW [] synonym: "stimulation of male pigmentation" NARROW [] synonym: "up regulation of male pigmentation" EXACT [] synonym: "up-regulation of male pigmentation" EXACT [] synonym: "upregulation of male pigmentation" EXACT [] is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0048088 ! regulation of male pigmentation is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0048094 ! male pigmentation [Term] id: GO:0048094 name: male pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in males." [GOC:jid] is_a: GO:0048071 ! sex-specific pigmentation relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0048095 name: female pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in females." [GOC:jid] is_a: GO:0048071 ! sex-specific pigmentation relationship: part_of GO:0046660 ! female sex differentiation [Term] id: GO:0048096 name: chromatin-mediated maintenance of transcription namespace: biological_process def: "Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jid] comment: Note that this process is the opposite of chromatin silencing. This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription. is_a: GO:0006338 ! chromatin remodeling is_a: GO:0045815 ! positive regulation of gene expression, epigenetic is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent [Term] id: GO:0048097 name: long-term maintenance of gene activation namespace: biological_process def: "Any mechanism, at the level of transcription or post-transcription, maintaining gene activation in the long-term." [GOC:jid] comment: Note that this process is the opposite of gene silencing. is_a: GO:0045815 ! positive regulation of gene expression, epigenetic [Term] id: GO:0048098 name: antennal joint development namespace: biological_process def: "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007469 ! antennal development [Term] id: GO:0048099 name: anterior/posterior lineage restriction, imaginal disc namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jid, PMID:10625531, PMID:9374402] is_a: GO:0035161 ! imaginal disc lineage restriction relationship: part_of GO:0007448 ! anterior/posterior pattern formation, imaginal disc [Term] id: GO:0048100 name: wing disc anterior/posterior pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531] is_a: GO:0007448 ! anterior/posterior pattern formation, imaginal disc is_a: GO:0035222 ! wing disc pattern formation [Term] id: GO:0048101 name: calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive." [GOC:jid] synonym: "calcium- and calmodulin-regulated cGMP phosphodiesterase activity" RELATED [] synonym: "calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] synonym: "calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity" EXACT [] synonym: "calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] is_a: GO:0047555 ! 3',5'-cyclic-GMP phosphodiesterase activity [Term] id: GO:0048102 name: autophagic cell death namespace: biological_process def: "A form of programmed cell death that is accompanied by macroautophagy, which is characterized by the sequestration of cytoplasmic material within autophagosomes for bulk degradation by lysosomes. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, and accumulation of (double-membraned) autophagic vacuoles, with little or no uptake by phagocytic cells." [GOC:mah, PMID:18846107] synonym: "autophagic death" BROAD [] synonym: "programmed cell death by autophagy" EXACT [] synonym: "type II programmed cell death" RELATED [GOC:sl] is_a: GO:0012501 ! programmed cell death [Term] id: GO:0048103 name: somatic stem cell division namespace: biological_process def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089] synonym: "somatic stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division [Term] id: GO:0048104 name: establishment of body hair or bristle planar orientation namespace: biological_process def: "Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity [Term] id: GO:0048105 name: establishment of body hair planar orientation namespace: biological_process def: "Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb] is_a: GO:0048104 ! establishment of body hair or bristle planar orientation [Term] id: GO:0048106 name: establishment of body bristle planar orientation namespace: biological_process def: "Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb] is_a: GO:0048104 ! establishment of body hair or bristle planar orientation relationship: part_of GO:0008407 ! bristle morphogenesis [Term] id: GO:0048107 name: 4-amino-3-isothiazolidinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively." [GOC:jid] subset: gosubset_prok synonym: "4-amino-3-isothiazolidinone anabolism" EXACT [] synonym: "4-amino-3-isothiazolidinone biosynthesis" EXACT [] synonym: "4-amino-3-isothiazolidinone formation" EXACT [] synonym: "4-amino-3-isothiazolidinone synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process [Term] id: GO:0048108 name: peptide cross-linking via 4-amino-3-isothiazolidinone namespace: biological_process def: "The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue." [GOC:jid, GOC:jsg] comment: Note that this is a generic parent because the identity of the second amino acid is not critical for formation of the cross-link. subset: gosubset_prok is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0048109 name: peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water." [GOC:jid, PMID:12802338, PMID:12802339, RESID:AA0344] subset: gosubset_prok xref: RESID:AA0344 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0048108 ! peptide cross-linking via 4-amino-3-isothiazolidinone [Term] id: GO:0048132 name: female germ-line stem cell division namespace: biological_process alt_id: GO:0048141 def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] synonym: "female germ-line stem cell renewal" EXACT [] is_a: GO:0042078 ! germ-line stem cell division relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0048133 name: male germ-line stem cell division namespace: biological_process def: "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jid] synonym: "male germ-line stem cell renewal" EXACT [] is_a: GO:0042078 ! germ-line stem cell division relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048134 name: germ-line cyst formation namespace: biological_process def: "Formation of a cluster of germ-line cells derived from a single founder cell." [GOC:jid, PMID:10370240] is_a: GO:0008283 ! cell proliferation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007281 ! germ cell development [Term] id: GO:0048135 name: female germ-line cyst formation namespace: biological_process def: "Formation of a cluster of germ-line cells, in the female gonad, derived from a single founder cell. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0048134 ! germ-line cyst formation relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0048136 name: male germ-line cyst formation namespace: biological_process def: "Formation of a cluster of germ-line cells, in the male gonad of an insect, derived from a single founder cell (cystoblast)." [GOC:jid] is_a: GO:0048134 ! germ-line cyst formation relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048137 name: spermatocyte division namespace: biological_process def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce a cyst of haploid spermatids." [GOC:jid, ISBN:0879694238] synonym: "spermatocyte cell division" EXACT [] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051301 ! cell division relationship: part_of GO:0048136 ! male germ-line cyst formation [Term] id: GO:0048138 name: germ-line cyst encapsulation namespace: biological_process def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst." [GOC:jid, PMID:11591336] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007276 ! gamete generation relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium [Term] id: GO:0048139 name: female germ-line cyst encapsulation namespace: biological_process def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad." [GOC:jid, PMID:11591336] is_a: GO:0048138 ! germ-line cyst encapsulation relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0048140 name: male germ-line cyst encapsulation namespace: biological_process def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad." [GOC:jid, PMID:11591336] is_a: GO:0048138 ! germ-line cyst encapsulation relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048142 name: germarium-derived cystoblast division namespace: biological_process def: "The four rounds of incomplete mitosis undergone by a cystoblast derived from the germarium to form a 16-cell cyst. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529] synonym: "cystoblast cell division" BROAD [] is_a: GO:0007282 ! cystoblast division relationship: part_of GO:0030727 ! germarium-derived female germ-line cyst formation [Term] id: GO:0048143 name: astrocyte activation namespace: biological_process def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813] is_a: GO:0001775 ! cell activation relationship: part_of GO:0014002 ! astrocyte development [Term] id: GO:0048144 name: fibroblast proliferation namespace: biological_process def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0048145 name: regulation of fibroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0048144 ! fibroblast proliferation [Term] id: GO:0048146 name: positive regulation of fibroblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "activation of fibroblast proliferation" NARROW [] synonym: "stimulation of fibroblast proliferation" NARROW [] synonym: "up regulation of fibroblast proliferation" EXACT [] synonym: "up-regulation of fibroblast proliferation" EXACT [] synonym: "upregulation of fibroblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation relationship: positively_regulates GO:0048144 ! fibroblast proliferation [Term] id: GO:0048147 name: negative regulation of fibroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "down regulation of fibroblast proliferation" EXACT [] synonym: "down-regulation of fibroblast proliferation" EXACT [] synonym: "downregulation of fibroblast proliferation" EXACT [] synonym: "inhibition of fibroblast proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation relationship: negatively_regulates GO:0048144 ! fibroblast proliferation [Term] id: GO:0048148 name: behavioral response to cocaine namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] synonym: "behavioural response to cocaine" EXACT [] is_a: GO:0030534 ! adult behavior is_a: GO:0042220 ! response to cocaine [Term] id: GO:0048149 name: behavioral response to ethanol namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] synonym: "behavioural response to ethanol" EXACT [] is_a: GO:0030534 ! adult behavior is_a: GO:0045471 ! response to ethanol [Term] id: GO:0048150 name: behavioral response to ether namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of an ether stimulus." [GOC:jid] synonym: "behavioural response to ether" EXACT [] is_a: GO:0030534 ! adult behavior is_a: GO:0045472 ! response to ether [Term] id: GO:0048151 name: hyperphosphorylation namespace: biological_process def: "OBSOLETE. The excessive phosphorylation of a protein, as a result of activation of kinases, deactivation of phosphatases, or both." [GOC:jid, ISBN:039751820X, PMID:12859672] comment: This term was made obsolete because it is an unnecessary grouping term and was poorly defined. is_obsolete: true replaced_by: GO:0016310 [Term] id: GO:0048152 name: S100 beta biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] synonym: "S100 beta anabolism" EXACT [] synonym: "S100 beta biosynthesis" EXACT [] synonym: "S100 beta formation" EXACT [] synonym: "S100 beta synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0048153 name: S100 alpha biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] synonym: "S100 alpha anabolism" EXACT [] synonym: "S100 alpha biosynthesis" EXACT [] synonym: "S100 alpha formation" EXACT [] synonym: "S100 alpha synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0048154 name: S100 beta binding namespace: molecular_function def: "Interacting selectively and non-covalently with S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] is_a: GO:0005515 ! protein binding [Term] id: GO:0048155 name: S100 alpha binding namespace: molecular_function def: "Interacting selectively and non-covalently with S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] is_a: GO:0005515 ! protein binding [Term] id: GO:0048156 name: tau protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0048158 name: oogonium stage namespace: biological_process def: "The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 1" EXACT [] is_a: GO:0022605 ! oogenesis stage [Term] id: GO:0048159 name: primary oocyte stage namespace: biological_process def: "The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 2" EXACT [] is_a: GO:0022605 ! oogenesis stage [Term] id: GO:0048160 name: primary follicle stage namespace: biological_process def: "The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 3" EXACT [] is_a: GO:0022605 ! oogenesis stage [Term] id: GO:0048161 name: double layer follicle stage namespace: biological_process def: "The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 4" EXACT [] is_a: GO:0022605 ! oogenesis stage [Term] id: GO:0048162 name: multi-layer follicle stage namespace: biological_process def: "The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 5" EXACT [] is_a: GO:0022605 ! oogenesis stage [Term] id: GO:0048163 name: scattered antral spaces stage namespace: biological_process def: "The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 6" EXACT [] is_a: GO:0022605 ! oogenesis stage [Term] id: GO:0048164 name: distinct antral spaces stage namespace: biological_process def: "The stage in oogenesis when the antral spaces become distinct and the first polar body forms." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 7" EXACT [] is_a: GO:0022605 ! oogenesis stage [Term] id: GO:0048165 name: fused antrum stage namespace: biological_process def: "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 8" EXACT [] is_a: GO:0022605 ! oogenesis stage [Term] id: GO:0048166 name: mature follicle stage namespace: biological_process def: "The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 9" EXACT [] is_a: GO:0022605 ! oogenesis stage [Term] id: GO:0048167 name: regulation of synaptic plasticity namespace: biological_process def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0050804 ! regulation of synaptic transmission is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0048168 name: regulation of neuronal synaptic plasticity namespace: biological_process def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0048169 name: regulation of long-term neuronal synaptic plasticity namespace: biological_process def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0048168 ! regulation of neuronal synaptic plasticity [Term] id: GO:0048170 name: positive regulation of long-term neuronal synaptic plasticity namespace: biological_process def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "activation of long-term neuronal synaptic plasticity" NARROW [] synonym: "stimulation of long-term neuronal synaptic plasticity" NARROW [] synonym: "up regulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "up-regulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "upregulation of long-term neuronal synaptic plasticity" EXACT [] is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity is_a: GO:0050769 ! positive regulation of neurogenesis [Term] id: GO:0048171 name: negative regulation of long-term neuronal synaptic plasticity namespace: biological_process def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "down regulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "down-regulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "downregulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "inhibition of long-term neuronal synaptic plasticity" NARROW [] is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity is_a: GO:0050768 ! negative regulation of neurogenesis [Term] id: GO:0048172 name: regulation of short-term neuronal synaptic plasticity namespace: biological_process def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0048168 ! regulation of neuronal synaptic plasticity [Term] id: GO:0048173 name: positive regulation of short-term neuronal synaptic plasticity namespace: biological_process def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "activation of short-term neuronal synaptic plasticity" NARROW [] synonym: "stimulation of short-term neuronal synaptic plasticity" NARROW [] synonym: "up regulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "up-regulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "upregulation of short-term neuronal synaptic plasticity" EXACT [] is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity is_a: GO:0050769 ! positive regulation of neurogenesis [Term] id: GO:0048174 name: negative regulation of short-term neuronal synaptic plasticity namespace: biological_process def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "down regulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "down-regulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "downregulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "inhibition of short-term neuronal synaptic plasticity" NARROW [] is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity is_a: GO:0050768 ! negative regulation of neurogenesis [Term] id: GO:0048175 name: hepatocyte growth factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hepacyte growth factor. Hepatocyte growth factor is a mitogen for a number of cell types and it is found in liver cells and in many other cell types, including platelets." [GOC:jid, PMID:1838014] synonym: "hepatocyte growth factor anabolism" EXACT [] synonym: "hepatocyte growth factor biosynthesis" EXACT [] synonym: "hepatocyte growth factor formation" EXACT [] synonym: "hepatocyte growth factor synthesis" EXACT [] synonym: "HGF biosynthesis" EXACT [] synonym: "HGF biosynthetic process" EXACT [] synonym: "scatter factor biosynthesis" EXACT [] synonym: "scatter factor biosynthetic process" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0048176 name: regulation of hepatocyte growth factor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jid, PMID:1838014] synonym: "regulation of hepatocyte growth factor anabolism" EXACT [] synonym: "regulation of hepatocyte growth factor biosynthesis" EXACT [] synonym: "regulation of hepatocyte growth factor formation" EXACT [] synonym: "regulation of hepatocyte growth factor synthesis" EXACT [] synonym: "regulation of HGF biosynthesis" EXACT [] synonym: "regulation of HGF biosynthetic process" EXACT [] synonym: "regulation of scatter factor biosynthesis" EXACT [] synonym: "regulation of scatter factor biosynthetic process" EXACT [] is_a: GO:0032646 ! regulation of hepatocyte growth factor production is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0048175 ! hepatocyte growth factor biosynthetic process [Term] id: GO:0048177 name: positive regulation of hepatocyte growth factor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jid, PMID:1838014] synonym: "activation of hepatocyte growth factor biosynthetic process" NARROW [] synonym: "positive regulation of hepatocyte growth factor anabolism" EXACT [] synonym: "positive regulation of hepatocyte growth factor biosynthesis" EXACT [] synonym: "positive regulation of hepatocyte growth factor formation" EXACT [] synonym: "positive regulation of hepatocyte growth factor synthesis" EXACT [] synonym: "positive regulation of HGF biosynthesis" EXACT [] synonym: "positive regulation of HGF biosynthetic process" EXACT [] synonym: "positive regulation of scatter factor biosynthesis" EXACT [] synonym: "positive regulation of scatter factor biosynthetic process" EXACT [] synonym: "stimulation of hepatocyte growth factor biosynthetic process" NARROW [] synonym: "up regulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "up-regulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "upregulation of hepatocyte growth factor biosynthetic process" EXACT [] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process relationship: positively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process [Term] id: GO:0048178 name: negative regulation of hepatocyte growth factor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jid, PMID:1838014] synonym: "down regulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "down-regulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "downregulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "inhibition of hepatocyte growth factor biosynthetic process" NARROW [] synonym: "negative regulation of hepatocyte growth factor anabolism" EXACT [] synonym: "negative regulation of hepatocyte growth factor biosynthesis" EXACT [] synonym: "negative regulation of hepatocyte growth factor formation" EXACT [] synonym: "negative regulation of hepatocyte growth factor synthesis" EXACT [] synonym: "negative regulation of HGF biosynthesis" EXACT [] synonym: "negative regulation of HGF biosynthetic process" EXACT [] synonym: "negative regulation of scatter factor biosynthesis" EXACT [] synonym: "negative regulation of scatter factor biosynthetic process" EXACT [] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process relationship: negatively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process [Term] id: GO:0048179 name: activin receptor complex namespace: cellular_component def: "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0048180 name: activin complex namespace: cellular_component def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0048183 name: activin AB complex namespace: cellular_component def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. synonym: "inhibin beta-A" NARROW [] synonym: "inhibin beta-B" NARROW [] is_a: GO:0048180 ! activin complex [Term] id: GO:0048184 name: follistatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the peptide hormone follistatin." [GOC:jid, GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0048185 name: activin binding namespace: molecular_function def: "Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits." [GOC:jid, GOC:mah] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0048186 name: inhibin beta-A binding namespace: molecular_function def: "Interacting selectively and non-covalently with inhibin beta-A." [GOC:jid] is_a: GO:0034711 ! inhibin binding [Term] id: GO:0048187 name: inhibin beta-B binding namespace: molecular_function def: "Interacting selectively and non-covalently with inhibin beta-B." [GOC:jid] is_a: GO:0034711 ! inhibin binding [Term] id: GO:0048188 name: Set1C/COMPASS complex namespace: cellular_component def: "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538] synonym: "COMPASS complex" EXACT [GOC:vw] synonym: "Set1/COMPASS complex" EXACT [GOC:mah] synonym: "Set1C" EXACT [GOC:vw] is_a: GO:0016585 ! chromatin remodeling complex is_a: GO:0035097 ! histone methyltransferase complex [Term] id: GO:0048189 name: Lid2 complex namespace: cellular_component def: "A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p." [PMID:12488447] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0048190 name: wing disc dorsal/ventral pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] synonym: "wing disc dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "wing disc dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0007450 ! dorsal/ventral pattern formation, imaginal disc is_a: GO:0035222 ! wing disc pattern formation [Term] id: GO:0048191 name: peptide stabilization activity namespace: molecular_function def: "OBSOLETE. Strengthening of a bond between peptides. Peptides are compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jid] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0050822 [Term] id: GO:0048192 name: peptide antigen stabilization activity namespace: molecular_function def: "OBSOLETE. Strengthening of a bond with a peptide antigen; a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jid] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0050823 [Term] id: GO:0048193 name: Golgi vesicle transport namespace: biological_process def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "Golgi-derived vesicle transport " RELATED [] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0048194 name: Golgi vesicle budding namespace: biological_process def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle budding" NARROW [] synonym: "Golgi-derived vesicle budding" EXACT [] is_a: GO:0006900 ! membrane budding relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048195 name: Golgi membrane priming complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "formation of dictyosome membrane priming complex" NARROW [] synonym: "formation of Golgi membrane priming complex" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0048200 ! Golgi transport vesicle coating [Term] id: GO:0048196 name: middle lamella-containing extracellular matrix namespace: cellular_component def: "The matrix external to the cell, composed of the cell wall and middle lamella." [GOC:jid, GOC:mtg_sensu, PMID:11351084, PMID:4327466] comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell. subset: goslim_pir is_a: GO:0030312 ! external encapsulating structure is_a: GO:0031012 ! extracellular matrix [Term] id: GO:0048197 name: Golgi membrane coat protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome membrane binding by cytosolic coat proteins" NARROW [] synonym: "dictyosome membrane bud coat oligomerisation" NARROW [] synonym: "Golgi membrane bud coat oligomerisation" NARROW [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0048200 ! Golgi transport vesicle coating [Term] id: GO:0048198 name: Golgi vesicle bud deformation and release namespace: biological_process def: "The process in which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle bud deformation" NARROW [] synonym: "Golgi-derived vesicle bud deformation and release" EXACT [] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0048194 ! Golgi vesicle budding [Term] id: GO:0048199 name: vesicle targeting, to, from or within Golgi namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle targeting" NARROW [] synonym: "Golgi vesicle targeting" EXACT [] synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] is_a: GO:0006903 ! vesicle targeting relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048200 name: Golgi transport vesicle coating namespace: biological_process def: "The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome transport vesicle coating" NARROW [] is_a: GO:0006901 ! vesicle coating relationship: part_of GO:0048194 ! Golgi vesicle budding relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi [Term] id: GO:0048201 name: vesicle targeting, plasma membrane to endosome namespace: biological_process def: "The process in which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "plasma membrane to endosome targeting" EXACT [] is_a: GO:0006903 ! vesicle targeting [Term] id: GO:0048202 name: clathrin coating of Golgi vesicle namespace: biological_process def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "clathrin coating of Golgi-derived vesicle" EXACT [] is_a: GO:0048200 ! Golgi transport vesicle coating is_a: GO:0048268 ! clathrin coat assembly [Term] id: GO:0048203 name: vesicle targeting, trans-Golgi to endosome namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "trans-Golgi to endosome targeting" EXACT [] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0006895 ! Golgi to endosome transport [Term] id: GO:0048204 name: vesicle targeting, inter-Golgi cisterna namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "inter-Golgi cisterna targeting" EXACT [] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport [Term] id: GO:0048205 name: COPI coating of Golgi vesicle namespace: biological_process def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "COPI coating of Golgi-derived vesicle" EXACT [] xref: Reactome:1253531 "COPI Mediated Transport" xref: Reactome:1280470 "COPI Mediated Transport" xref: Reactome:1299295 "COPI Mediated Transport" xref: Reactome:1327048 "COPI Mediated Transport" xref: Reactome:1353142 "COPI Mediated Transport" xref: Reactome:1373321 "COPI Mediated Transport" xref: Reactome:1393343 "COPI Mediated Transport" xref: Reactome:1417839 "COPI Mediated Transport" xref: Reactome:1450930 "COPI Mediated Transport" xref: Reactome:1471317 "COPI Mediated Transport" xref: Reactome:1483289 "COPI Mediated Transport" xref: Reactome:1496976 "COPI Mediated Transport" xref: Reactome:1514363 "COPI Mediated Transport" xref: Reactome:1521236 "COPI Mediated Transport" xref: Reactome:1526949 "COPI Mediated Transport" xref: Reactome:1532684 "COPI Mediated Transport" xref: Reactome:1536097 "COPI Mediated Transport" xref: Reactome:199997 "COPI Mediated Transport" is_a: GO:0048200 ! Golgi transport vesicle coating [Term] id: GO:0048206 name: vesicle targeting, cis-Golgi to rough ER namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "cis-Golgi to rough endoplasmic reticulum targeting" EXACT [] synonym: "cis-Golgi to rough ER targeting" EXACT [] synonym: "vesicle targeting, cis-Golgi to rough endoplasmic reticulum" EXACT [] is_a: GO:0006890 ! retrograde vesicle-mediated transport, Golgi to ER is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi [Term] id: GO:0048207 name: vesicle targeting, rough ER to cis-Golgi namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "rough endoplasmic reticulum to cis-Golgi targeting" EXACT [] synonym: "rough ER to cis-Golgi targeting" EXACT [] synonym: "vesicle targeting, rough endoplasmic reticulum to cis-Golgi" EXACT [] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport [Term] id: GO:0048208 name: COPII vesicle coating namespace: biological_process def: "The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233] synonym: "COPII coating of ER-derived vesicle" EXACT [GOC:tb] synonym: "COPII vesicle coat assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "COPII vesicle coat formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] xref: Reactome:1253552 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1280491 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1299319 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1327070 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1353164 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1373342 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1393364 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1417862 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1450950 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1471331 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1483299 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1496983 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1514370 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1521246 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1526961 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1532697 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:1536103 "COPII (Coat Protein 2) Mediated Vesicle Transport" xref: Reactome:204005 "COPII (Coat Protein 2) Mediated Vesicle Transport" is_a: GO:0006901 ! vesicle coating relationship: part_of GO:0048207 ! vesicle targeting, rough ER to cis-Golgi relationship: part_of GO:0090114 ! COPII-coated vesicle budding [Term] id: GO:0048209 name: regulation of vesicle targeting, to, from or within Golgi namespace: biological_process def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "regulation of Golgi vesicle targeting" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi [Term] id: GO:0048210 name: Golgi vesicle fusion to target membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle fusion to target membrane" NARROW [] synonym: "Golgi-derived vesicle fusion to target membrane" EXACT [] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048211 name: Golgi vesicle docking namespace: biological_process def: "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle docking to target membrane" NARROW [] synonym: "Golgi vesicle docking with target membrane" EXACT [] synonym: "Golgi vesicle to membrane docking" EXACT [] synonym: "Golgi-derived vesicle docking" EXACT [] is_a: GO:0048278 ! vesicle docking relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048212 name: Golgi vesicle uncoating namespace: biological_process def: "The process in which Golgi vesicle coat proteins are depolymerized, and released for reuse." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle coat depolymerization" NARROW [] synonym: "Golgi vesicle coat depolymerization" EXACT [] synonym: "Golgi vesicle coat protein depolymerization" EXACT [] synonym: "Golgi-derived vesicle uncoating" EXACT [] is_a: GO:0072319 ! vesicle uncoating relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048213 name: Golgi vesicle prefusion complex stabilization namespace: biological_process def: "The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle prefusion complex stabilisation" NARROW [] synonym: "Golgi vesicle prefusion complex assembly" EXACT [] synonym: "Golgi-derived vesicle prefusion complex stabilization" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048214 name: regulation of Golgi vesicle fusion to target membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] comment: Note that GTP-binding Rab proteins serve as regulators of vesicle targeting and fusion. is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0032386 ! regulation of intracellular transport relationship: regulates GO:0048210 ! Golgi vesicle fusion to target membrane [Term] id: GO:0048215 name: positive regulation of Golgi vesicle fusion to target membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "activation of Golgi vesicle fusion to target membrane" NARROW [] synonym: "stimulation of Golgi vesicle fusion to target membrane" NARROW [] synonym: "up regulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "up-regulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "upregulation of Golgi vesicle fusion to target membrane" EXACT [] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane relationship: positively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane [Term] id: GO:0048216 name: negative regulation of Golgi vesicle fusion to target membrane namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "down regulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "down-regulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "downregulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "inhibition of Golgi vesicle fusion to target membrane" NARROW [] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane relationship: negatively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane [Term] id: GO:0048217 name: pectic matrix namespace: cellular_component def: "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls." [GOC:jid, PMID:11554482] is_a: GO:0044420 ! extracellular matrix part is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009530 ! primary cell wall relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048219 name: inter-Golgi cisterna vesicle-mediated transport namespace: biological_process def: "The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "inter-Golgi cisterna transport" EXACT [] is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048222 name: glycoprotein network namespace: cellular_component def: "An extracellular matrix part that consists of cross-linked glycoproteins." [GOC:mah, PMID:18508691, PMID:7048321] synonym: "extensin" EXACT [] xref: Wikipedia:Extensin is_a: GO:0044420 ! extracellular matrix part is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009530 ! primary cell wall [Term] id: GO:0048223 name: hemicellulose network namespace: cellular_component def: "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan." [DOI:10.1016/j.foodchem.2008.11.065, GOC:jid] is_a: GO:0044420 ! extracellular matrix part is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009530 ! primary cell wall relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048224 name: lignin network namespace: cellular_component def: "An extracellular matrix part that consists of lignin in the form of a three-dimensional polymeric network. Lignins are complex racemic aromatic heteropolymers derived from a variety of phenylpropane monomers coupled together by an assortment of carbon-carbon and ether linkages. Lignin is crucial for structural integrity of the cell wall and stiffness and strength of the stem. In addition, lignin waterproofs the cell wall, enabling transport of water and solutes through the vascular system, and plays a role in protecting plants against pathogens." [GOC:jid, GOC:mah, PMID:14503002, PMID:16662709] is_a: GO:0044420 ! extracellular matrix part is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048225 name: suberin network namespace: cellular_component def: "An extracellular matrix part that consists of fatty acid-derived polymers, including both aromatic and aliphatic components. The suberin network is found in specialized plant cell walls, where it is laid down between the primary wall and plasmalemma, forms protective and wound-healing layers, and provides a water-impermeable diffusion barrier." [GOC:jid, GOC:mah, PMID:18440267, PMID:7706282] is_a: GO:0044420 ! extracellular matrix part is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048226 name: Casparian strip namespace: cellular_component def: "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants." [GOC:jid] xref: Wikipedia:Casparian_strip is_a: GO:0044420 ! extracellular matrix part is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048227 name: plasma membrane to endosome transport namespace: biological_process def: "Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid] is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0048228 name: actin cortical patch distribution namespace: biological_process def: "OBSOLETE. Any process that establishes the spatial arrangement of actin cortical patches. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells." [GOC:jid] comment: This term was made obsolete because its definition is very similar to that of its parent term, actin cortical patch localization (GO:0051666), but somewhat unclear, and not similar enough to merge the terms. is_obsolete: true [Term] id: GO:0048229 name: gametophyte development namespace: biological_process def: "The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. An example of this process is found in Arabidopsis thaliana." [GOC:jid, PO:0009004] synonym: "gametogenesis" BROAD [] is_a: GO:0007275 ! multicellular organismal development [Term] id: GO:0048232 name: male gamete generation namespace: biological_process def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid] is_a: GO:0007276 ! gamete generation [Term] id: GO:0048235 name: pollen sperm cell differentiation namespace: biological_process alt_id: GO:0048234 def: "The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte." [CL:0000366, GOC:jid, GOC:mtg_sensu] synonym: "male gamete generation" BROAD [] synonym: "male gametophyte sperm cell differentiation" EXACT [] synonym: "sperm cell differentiation" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048232 ! male gamete generation relationship: part_of GO:0055046 ! microgametogenesis [Term] id: GO:0048236 name: plant-type spore development namespace: biological_process def: "The process whose specific outcome is the progression of the spore over time, from its formation to the mature structure. The spore gives rise to gametophytes." [GOC:jid, http://www.m-w.com] synonym: "plant spore development" EXACT [] is_a: GO:0048869 ! cellular developmental process is_a: GO:0051321 ! meiotic cell cycle [Term] id: GO:0048237 name: rough endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jid] synonym: "RER lumen" EXACT [] synonym: "rough ER lumen" EXACT [] xref: NIF_Subcellular:sao1819509473 is_a: GO:0005788 ! endoplasmic reticulum lumen relationship: part_of GO:0005791 ! rough endoplasmic reticulum [Term] id: GO:0048238 name: smooth endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jid] synonym: "SER lumen" EXACT [] synonym: "smooth ER lumen" EXACT [] xref: NIF_Subcellular:sao927884761 is_a: GO:0005788 ! endoplasmic reticulum lumen relationship: part_of GO:0005790 ! smooth endoplasmic reticulum [Term] id: GO:0048239 name: negative regulation of DNA recombination at telomere namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere." [GOC:jid, PMID:9635193] synonym: "down regulation of telomeric recombination at telomere" EXACT [] synonym: "down-regulation of telomeric recombination at telomere" EXACT [] synonym: "downregulation of telomeric recombination at telomere" EXACT [] synonym: "inhibition of telomeric recombination at telomere" NARROW [] synonym: "negative regulation of telomeric recombination at telomere" EXACT [GOC:tb] synonym: "suppression of telomeric recombination at telomere" EXACT [] is_a: GO:0000722 ! telomere maintenance via recombination is_a: GO:0045910 ! negative regulation of DNA recombination [Term] id: GO:0048240 name: sperm capacitation namespace: biological_process def: "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, PMID:11820818] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0048241 name: epinephrine transport namespace: biological_process def: "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jid] synonym: "adrenaline transport" EXACT [] is_a: GO:0009914 ! hormone transport is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0048242 name: epinephrine secretion namespace: biological_process def: "The regulated release of epinephrine by a cell or group of cells. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." [GOC:ef, GOC:jid] synonym: "adrenaline secretion" EXACT [] is_a: GO:0048241 ! epinephrine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0048243 name: norepinephrine secretion namespace: biological_process def: "The regulated release of norepinephrine by a cell or group of cells. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid] synonym: "noradrenaline secretion" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0048244 name: phytanoyl-CoA dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate." [EC:1.14.11.18, RHEA:16068] synonym: "phytanoyl-CoA 2 oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA 2-hydroxylase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA alpha-hydroxylase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA hydroxylase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.11.18] xref: EC:1.14.11.18 xref: KEGG:R05722 xref: MetaCyc:1.14.11.18-RXN xref: Reactome:78983 "phytanoyl-CoA dioxygenase activity" xref: RHEA:16068 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0048245 name: eosinophil chemotaxis namespace: biological_process def: "The movement of an eosinophil in response to an external stimulus." [GOC:jid, PMID:11292027, PMID:12391252] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0072677 ! eosinophil migration [Term] id: GO:0048246 name: macrophage chemotaxis namespace: biological_process def: "The movement of a macrophage in response to an external stimulus." [GOC:jid] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0048247 name: lymphocyte chemotaxis namespace: biological_process def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jid, PMID:12391252] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0072676 ! lymphocyte migration [Term] id: GO:0048248 name: CXCR3 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a the CXCR3 chemokine receptor." [GOC:jid, PMID:10556837] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0048249 name: high affinity phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphate from one side of the membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jid, PMID:8709965] is_a: GO:0015114 ! phosphate transmembrane transporter activity [Term] id: GO:0048250 name: mitochondrial iron ion transport namespace: biological_process def: "The directed movement of iron ions into, out of or within a mitochondrion." [GOC:jid, PMID:12006577] synonym: "mitochondrial iron transport" EXACT [] is_a: GO:0006826 ! iron ion transport is_a: GO:0006839 ! mitochondrial transport [Term] id: GO:0048251 name: elastic fiber assembly namespace: biological_process def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674] synonym: "elastic fibre assembly" EXACT [] is_a: GO:0085029 ! extracellular matrix assembly [Term] id: GO:0048252 name: lauric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid] subset: gosubset_prok synonym: "lauric acid metabolism" EXACT [] synonym: "n-dodecanoic acid metabolic process" EXACT [] synonym: "n-dodecanoic acid metabolism" EXACT [] is_a: GO:0001676 ! long-chain fatty acid metabolic process [Term] id: GO:0048254 name: snoRNA localization namespace: biological_process def: "Any process in which small nucleolar RNA is transported to, or maintained in, a specific location." [ISBN:0716731363] synonym: "establishment and maintenance of snoRNA localization" EXACT [] synonym: "small nucleolar RNA localization" EXACT [] synonym: "snoRNA localisation" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization [Term] id: GO:0048255 name: mRNA stabilization namespace: biological_process def: "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] subset: gosubset_prok is_a: GO:0043488 ! regulation of mRNA stability is_a: GO:0043489 ! RNA stabilization [Term] id: GO:0048256 name: flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid] subset: gosubset_prok xref: EC:3.1.-.-. is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0048257 name: 3'-flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid, PMID:10635319] synonym: "3' flap endonuclease activity" EXACT [] is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters is_a: GO:0048256 ! flap endonuclease activity [Term] id: GO:0048258 name: 3-ketoglucose-reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose." [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN] xref: EC:1.1.1.- xref: MetaCyc:KETOGLUCOSE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0048259 name: regulation of receptor-mediated endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb] synonym: "regulation of receptor mediated endocytosis" EXACT [GOC:tb] is_a: GO:0030100 ! regulation of endocytosis relationship: regulates GO:0006898 ! receptor-mediated endocytosis [Term] id: GO:0048260 name: positive regulation of receptor-mediated endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb] synonym: "activation of receptor mediated endocytosis" NARROW [] synonym: "positive regulation of receptor mediated endocytosis" EXACT [GOC:tb] synonym: "stimulation of receptor mediated endocytosis" NARROW [] synonym: "up regulation of receptor mediated endocytosis" EXACT [] synonym: "up-regulation of receptor mediated endocytosis" EXACT [] synonym: "upregulation of receptor mediated endocytosis" EXACT [] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:0048259 ! regulation of receptor-mediated endocytosis relationship: positively_regulates GO:0006898 ! receptor-mediated endocytosis [Term] id: GO:0048261 name: negative regulation of receptor-mediated endocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators] synonym: "down regulation of receptor mediated endocytosis" EXACT [] synonym: "down-regulation of receptor mediated endocytosis" EXACT [] synonym: "downregulation of receptor mediated endocytosis" EXACT [] synonym: "inhibition of receptor mediated endocytosis" NARROW [] synonym: "negative regulation of receptor mediated endocytosis" EXACT [] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:0048259 ! regulation of receptor-mediated endocytosis relationship: negatively_regulates GO:0006898 ! receptor-mediated endocytosis [Term] id: GO:0048262 name: determination of dorsal/ventral asymmetry namespace: biological_process def: "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis." [GOC:jid] synonym: "determination of adaxial/abaxial asymmetry" RELATED [GOC:dph, GOC:tb] synonym: "determination of dorsal-ventral asymmetry" EXACT [GOC:mah] synonym: "determination of dorsoventral asymmetry" EXACT [GOC:mah] is_a: GO:0009855 ! determination of bilateral symmetry relationship: part_of GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0048263 name: determination of dorsal identity namespace: biological_process def: "Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:jid] synonym: "determination of adaxial identity" RELATED [GOC:dph, GOC:tb] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry [Term] id: GO:0048264 name: determination of ventral identity namespace: biological_process def: "The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph, GOC:isa_complete, GOC:jid] synonym: "determination of abaxial identity" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry [Term] id: GO:0048265 name: response to pain namespace: biological_process alt_id: GO:0048267 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid, http://www.wikipedia.org/Pain, PMID:10203867, PMID:12723742, PMID:12843304] synonym: "physiological response to pain" EXACT [] is_a: GO:0033555 ! multicellular organismal response to stress [Term] id: GO:0048266 name: behavioral response to pain namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid] synonym: "behavioural response to pain" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0048265 ! response to pain [Term] id: GO:0048268 name: clathrin coat assembly namespace: biological_process def: "The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549] synonym: "clathrin cage assembly" EXACT [] is_a: GO:0006901 ! vesicle coating is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0048269 name: methionine adenosyltransferase complex namespace: cellular_component def: "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules." [EC:2.5.1.6, GOC:jid, PMID:10644686] synonym: "MAT complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0048270 name: methionine adenosyltransferase regulator activity namespace: molecular_function def: "Modulates the activity of methionine adenosyltransferase." [EC:2.5.1.6, GOC:jid, PMID:10644686] comment: See also the molecular function term 'methionine adenosyltransferase activity ; GO:0004478'. synonym: "MAT regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0048273 name: mitogen-activated protein kinase p38 binding namespace: molecular_function def: "Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation." [GOC:curators, PMID:17827184] synonym: "MAPK p38 binding" EXACT [] is_a: GO:0051019 ! mitogen-activated protein kinase binding [Term] id: GO:0048275 name: N-terminal peptidyl-arginine acetylation namespace: biological_process def: "The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase." [GOC:jsg, PMID:12883043, RESID:AA0354] subset: gosubset_prok xref: RESID:AA0354 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0048277 name: nonexocytotic vesicle docking namespace: biological_process def: "OBSOLETE. The initial attachment of a transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during a non-exocytotic process." [GOC:jid] comment: This term was made obsolete because it violates the principle of positivity. synonym: "non-exocytotic vesicle docking" EXACT [] is_obsolete: true replaced_by: GO:0048278 [Term] id: GO:0048278 name: vesicle docking namespace: biological_process def: "The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid] subset: gosubset_prok synonym: "vesicle to membrane docking" EXACT [] is_a: GO:0022406 ! membrane docking relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0048279 name: vesicle fusion with endoplasmic reticulum namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum." [GOC:jid] synonym: "vesicle fusion with ER" EXACT [] is_a: GO:0006906 ! vesicle fusion [Term] id: GO:0048280 name: vesicle fusion with Golgi apparatus namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048281 name: inflorescence morphogenesis namespace: biological_process def: "The process in which the anatomical structures of inflorescences are generated and organized. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0010229 ! inflorescence development [Term] id: GO:0048282 name: determinate inflorescence morphogenesis namespace: biological_process def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can only produce a predetermined number of floral meristems." [GOC:jid, PMID:9553044] is_a: GO:0048281 ! inflorescence morphogenesis [Term] id: GO:0048283 name: indeterminate inflorescence morphogenesis namespace: biological_process def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can produce an undefined number of floral meristems." [GOC:jid] is_a: GO:0048281 ! inflorescence morphogenesis [Term] id: GO:0048284 name: organelle fusion namespace: biological_process def: "The creation of a single organelle from two or more organelles." [GOC:jid] subset: goslim_pir is_a: GO:0006996 ! organelle organization [Term] id: GO:0048285 name: organelle fission namespace: biological_process def: "The creation of two or more organelles by division of one organelle." [GOC:jid] subset: goslim_pir is_a: GO:0006996 ! organelle organization [Term] id: GO:0048286 name: lung alveolus development namespace: biological_process def: "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways." [GOC:mtg_lung, PMID:9751757] synonym: "alveolarization" EXACT [PMID:17911382] synonym: "alveologenesis" EXACT [GOC:17911382] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0048288 name: nuclear membrane fusion involved in karyogamy namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid] synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0000740 ! nuclear membrane fusion relationship: part_of GO:0000741 ! karyogamy [Term] id: GO:0048289 name: isotype switching to IgE isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655] synonym: "class switch recombination to IgE isotypes" EXACT [] synonym: "class switching to IgE isotypes" EXACT [] synonym: "isotype switch recombination to IgE isotypes" EXACT [] is_a: GO:0045190 ! isotype switching [Term] id: GO:0048290 name: isotype switching to IgA isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655] synonym: "class switching to IgA isotypes" EXACT [] synonym: "isotype switch recombination to IgA isotypes" EXACT [] is_a: GO:0045190 ! isotype switching [Term] id: GO:0048291 name: isotype switching to IgG isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655] synonym: "class switching to IgG isotypes" EXACT [] synonym: "isotype switch recombination to IgG isotypes" EXACT [] is_a: GO:0045190 ! isotype switching [Term] id: GO:0048292 name: isotype switching to IgD isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655] comment: Note that this term is to be used only for gene products involved in the expression of IgD through recombinational switching into the vestigial switch region at the 5' end of the IgD gene segment, rather than gene products involved in the expression of IgD through alternative splicing mechanisms. synonym: "class switching to IgD isotypes" EXACT [] synonym: "isotype switch recombination to IgD isotypes" EXACT [] is_a: GO:0045190 ! isotype switching [Term] id: GO:0048293 name: regulation of isotype switching to IgE isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] synonym: "regulation of class switch recombination to IgE isotypes" EXACT [] synonym: "regulation of class switching to IgE isotypes" EXACT [] synonym: "regulation of isotype switch recombination to IgE isotypes" EXACT [] is_a: GO:0045191 ! regulation of isotype switching relationship: regulates GO:0048289 ! isotype switching to IgE isotypes [Term] id: GO:0048294 name: negative regulation of isotype switching to IgE isotypes namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] synonym: "down regulation of isotype switching to IgE isotypes" EXACT [] synonym: "down-regulation of isotype switching to IgE isotypes" EXACT [] synonym: "downregulation of isotype switching to IgE isotypes" EXACT [] synonym: "inhibition of isotype switching to IgE isotypes" NARROW [] synonym: "negative regulation of class switch recombination to IgE isotypes" EXACT [] synonym: "negative regulation of class switching to IgE isotypes" EXACT [] synonym: "negative regulation of isotype switch recombination to IgE isotypes" EXACT [] is_a: GO:0045829 ! negative regulation of isotype switching is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes relationship: negatively_regulates GO:0048289 ! isotype switching to IgE isotypes [Term] id: GO:0048295 name: positive regulation of isotype switching to IgE isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] synonym: "activation of isotype switching to IgE isotypes" NARROW [] synonym: "positive regulation of class switch recombination to IgE isotypes" EXACT [] synonym: "positive regulation of class switching to IgE isotypes" EXACT [] synonym: "positive regulation of isotype switch recombination to IgE isotypes" EXACT [] synonym: "stimulation of isotype switching to IgE isotypes" NARROW [] synonym: "up regulation of isotype switching to IgE isotypes" EXACT [] synonym: "up-regulation of isotype switching to IgE isotypes" EXACT [] synonym: "upregulation of isotype switching to IgE isotypes" EXACT [] is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes relationship: positively_regulates GO:0048289 ! isotype switching to IgE isotypes [Term] id: GO:0048296 name: regulation of isotype switching to IgA isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid] synonym: "regulation of class switch recombination to IgA isotypes" EXACT [] synonym: "regulation of class switching to IgA isotypes" EXACT [] synonym: "regulation of isotype switch recombination to IgA isotypes" EXACT [] is_a: GO:0045191 ! regulation of isotype switching relationship: regulates GO:0048290 ! isotype switching to IgA isotypes [Term] id: GO:0048297 name: negative regulation of isotype switching to IgA isotypes namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid] synonym: "down regulation of isotype switching to IgA isotypes" EXACT [] synonym: "down-regulation of isotype switching to IgA isotypes" EXACT [] synonym: "downregulation of isotype switching to IgA isotypes" EXACT [] synonym: "inhibition of isotype switching to IgA isotypes" NARROW [] synonym: "negative regulation of class switch recombination to IgA isotypes" EXACT [] synonym: "negative regulation of class switching to IgA isotypes" EXACT [] synonym: "negative regulation of isotype switch recombination to IgA isotypes" EXACT [] is_a: GO:0045829 ! negative regulation of isotype switching is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes relationship: negatively_regulates GO:0048290 ! isotype switching to IgA isotypes [Term] id: GO:0048298 name: positive regulation of isotype switching to IgA isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid] synonym: "activation of isotype switching to IgA isotypes" NARROW [] synonym: "positive regulation of class switch recombination to IgA isotypes" EXACT [] synonym: "positive regulation of class switching to IgA isotypes" EXACT [] synonym: "positive regulation of isotype switch recombination to IgA isotypes" EXACT [] synonym: "stimulation of isotype switching to IgA isotypes" NARROW [] synonym: "up regulation of isotype switching to IgA isotypes" EXACT [] synonym: "up-regulation of isotype switching to IgA isotypes" EXACT [] synonym: "upregulation of isotype switching to IgA isotypes" EXACT [] is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes relationship: positively_regulates GO:0048290 ! isotype switching to IgA isotypes [Term] id: GO:0048299 name: regulation of isotype switching to IgD isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid] synonym: "regulation of class switch recombination to IgD isotypes" EXACT [] synonym: "regulation of class switching to IgD isotypes" EXACT [] synonym: "regulation of isotype switch recombination to IgD isotypes" EXACT [] is_a: GO:0045191 ! regulation of isotype switching relationship: regulates GO:0048292 ! isotype switching to IgD isotypes [Term] id: GO:0048300 name: negative regulation of isotype switching to IgD isotypes namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid] synonym: "down regulation of isotype switching to IgD isotypes" EXACT [] synonym: "down-regulation of isotype switching to IgD isotypes" EXACT [] synonym: "downregulation of isotype switching to IgD isotypes" EXACT [] synonym: "inhibition of isotype switching to IgD isotypes" NARROW [] synonym: "negative regulation of class switch recombination to IgD isotypes" EXACT [] synonym: "negative regulation of class switching to IgD isotypes" EXACT [] synonym: "negative regulation of isotype switch recombination to IgD isotypes" EXACT [] is_a: GO:0045829 ! negative regulation of isotype switching is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes relationship: negatively_regulates GO:0048292 ! isotype switching to IgD isotypes [Term] id: GO:0048301 name: positive regulation of isotype switching to IgD isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid] synonym: "activation of isotype switching to IgD isotypes" NARROW [] synonym: "positive regulation of class switch recombination to IgD isotypes" EXACT [] synonym: "positive regulation of class switching to IgD isotypes" EXACT [] synonym: "positive regulation of isotype switch recombination to IgD isotypes" EXACT [] synonym: "stimulation of isotype switching to IgD isotypes" NARROW [] synonym: "up regulation of isotype switching to IgD isotypes" EXACT [] synonym: "up-regulation of isotype switching to IgD isotypes" EXACT [] synonym: "upregulation of isotype switching to IgD isotypes" EXACT [] is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes relationship: positively_regulates GO:0048292 ! isotype switching to IgD isotypes [Term] id: GO:0048302 name: regulation of isotype switching to IgG isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid] synonym: "regulation of class switch recombination to IgG isotypes" EXACT [] synonym: "regulation of class switching to IgG isotypes" EXACT [] synonym: "regulation of isotype switch recombination to IgG isotypes" EXACT [] is_a: GO:0045191 ! regulation of isotype switching relationship: regulates GO:0048291 ! isotype switching to IgG isotypes [Term] id: GO:0048303 name: negative regulation of isotype switching to IgG isotypes namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid] synonym: "down regulation of isotype switching to IgG isotypes" EXACT [] synonym: "down-regulation of isotype switching to IgG isotypes" EXACT [] synonym: "downregulation of isotype switching to IgG isotypes" EXACT [] synonym: "inhibition of isotype switching to IgG isotypes" NARROW [] synonym: "negative regulation of class switch recombination to IgG isotypes" EXACT [] synonym: "negative regulation of class switching to IgG isotypes" EXACT [] synonym: "negative regulation of isotype switch recombination to IgG isotypes" EXACT [] is_a: GO:0045829 ! negative regulation of isotype switching is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes relationship: negatively_regulates GO:0048291 ! isotype switching to IgG isotypes [Term] id: GO:0048304 name: positive regulation of isotype switching to IgG isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid] synonym: "activation of isotype switching to IgG isotypes" NARROW [] synonym: "positive regulation of class switch recombination to IgG isotypes" EXACT [] synonym: "positive regulation of class switching to IgG isotypes" EXACT [] synonym: "positive regulation of isotype switch recombination to IgG isotypes" EXACT [] synonym: "stimulation of isotype switching to IgG isotypes" NARROW [] synonym: "up regulation of isotype switching to IgG isotypes" EXACT [] synonym: "up-regulation of isotype switching to IgG isotypes" EXACT [] synonym: "upregulation of isotype switching to IgG isotypes" EXACT [] is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes relationship: positively_regulates GO:0048291 ! isotype switching to IgG isotypes [Term] id: GO:0048305 name: immunoglobulin secretion namespace: biological_process def: "The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:9185563] synonym: "antibody secretion" EXACT [] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0048306 name: calcium-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium." [GOC:jid, PMID:10485905] is_a: GO:0005515 ! protein binding [Term] id: GO:0048307 name: ferredoxin-nitrite reductase activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+." [EC:1.7.7.1, GOC:jid] subset: gosubset_prok synonym: "ammonia:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.1] xref: EC:1.7.7.1 xref: MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor [Term] id: GO:0048308 name: organelle inheritance namespace: biological_process def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid] subset: goslim_pir is_a: GO:0006996 ! organelle organization [Term] id: GO:0048309 name: endoplasmic reticulum inheritance namespace: biological_process def: "The partitioning of endoplasmic reticulum between daughter cells at cell division." [GOC:jid] synonym: "ER inheritance" EXACT [] is_a: GO:0007029 ! endoplasmic reticulum organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0048310 name: nucleus inheritance namespace: biological_process def: "The partitioning of nuclei between daughter cells at cell division." [GOC:jid] synonym: "cell nucleus inheritance" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0048311 name: mitochondrion distribution namespace: biological_process def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid] synonym: "distribution of mitochondria" EXACT [] synonym: "mitochondrial distribution" EXACT [] synonym: "positioning of mitochondria" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0051646 ! mitochondrion localization [Term] id: GO:0048312 name: intracellular distribution of mitochondria namespace: biological_process def: "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid] synonym: "mitochondria positioning within cell" EXACT [] synonym: "mitochondrion positioning within cell" EXACT [] is_a: GO:0048311 ! mitochondrion distribution [Term] id: GO:0048313 name: Golgi inheritance namespace: biological_process def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069] synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi partitioning" EXACT [] is_a: GO:0007030 ! Golgi organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0048314 name: embryo sac morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryo sac are generated and organized. The embryo sac develops from the megaspore in heterosporous plants." [GOC:jid, GOC:mtg_plant, http://www.bio.uu.nl] synonym: "female gametophyte morphogenesis" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0048315 name: conidium formation namespace: biological_process def: "Formation of asexual, nonmotile spores in fungi, by conversion of hyphal elements or arising from specialized sporogenous cells." [ISBN:0963117211, PMID:2524423, PMID:9529886] synonym: "conidia biosynthesis" EXACT [] synonym: "conidia formation" EXACT [] is_a: GO:0030436 ! asexual sporulation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0048316 name: seed development namespace: biological_process def: "The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves." [GOC:jid, PO:0009010] is_a: GO:0009791 ! post-embryonic development is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0010154 ! fruit development [Term] id: GO:0048317 name: seed morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the seed are generated and organized." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0048316 ! seed development [Term] id: GO:0048318 name: axial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh] is_a: GO:0007498 ! mesoderm development [Term] id: GO:0048319 name: axial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis relationship: part_of GO:0048318 ! axial mesoderm development [Term] id: GO:0048320 name: axial mesoderm formation namespace: biological_process def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] is_a: GO:0001707 ! mesoderm formation relationship: part_of GO:0048319 ! axial mesoderm morphogenesis [Term] id: GO:0048321 name: axial mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an axial mesoderm cell." [GOC:dgh] synonym: "axial mesoderm cell differentiation" EXACT [] is_a: GO:0048333 ! mesodermal cell differentiation relationship: part_of GO:0048320 ! axial mesoderm formation [Term] id: GO:0048322 name: axial mesodermal cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become an axial mesoderm cell." [GOC:dgh] synonym: "axial mesoderm cell fate commitment" EXACT [] is_a: GO:0001710 ! mesodermal cell fate commitment relationship: part_of GO:0048321 ! axial mesodermal cell differentiation [Term] id: GO:0048323 name: axial mesodermal cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] synonym: "axial mesoderm cell fate determination" EXACT [] is_a: GO:0007500 ! mesodermal cell fate determination relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment [Term] id: GO:0048324 name: regulation of axial mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] is_a: GO:0048334 ! regulation of mesodermal cell fate determination relationship: regulates GO:0048323 ! axial mesodermal cell fate determination [Term] id: GO:0048325 name: negative regulation of axial mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] synonym: "down regulation of axial mesodermal cell fate determination" EXACT [] synonym: "down-regulation of axial mesodermal cell fate determination" EXACT [] synonym: "downregulation of axial mesodermal cell fate determination" EXACT [] synonym: "inhibition of axial mesodermal cell fate determination" NARROW [] is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination relationship: negatively_regulates GO:0048323 ! axial mesodermal cell fate determination [Term] id: GO:0048326 name: positive regulation of axial mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] synonym: "activation of axial mesodermal cell fate determination" NARROW [] synonym: "stimulation of axial mesodermal cell fate determination" NARROW [] synonym: "up regulation of axial mesodermal cell fate determination" EXACT [] synonym: "up-regulation of axial mesodermal cell fate determination" EXACT [] synonym: "upregulation of axial mesodermal cell fate determination" EXACT [] is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination relationship: positively_regulates GO:0048323 ! axial mesodermal cell fate determination [Term] id: GO:0048327 name: axial mesodermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] synonym: "axial mesoderm cell fate specification" EXACT [] is_a: GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment [Term] id: GO:0048328 name: regulation of axial mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] is_a: GO:0042661 ! regulation of mesodermal cell fate specification relationship: regulates GO:0048327 ! axial mesodermal cell fate specification [Term] id: GO:0048329 name: negative regulation of axial mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] synonym: "down regulation of axial mesodermal cell fate specification" EXACT [] synonym: "down-regulation of axial mesodermal cell fate specification" EXACT [] synonym: "downregulation of axial mesodermal cell fate specification" EXACT [] synonym: "inhibition of axial mesodermal cell fate specification" NARROW [] is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification relationship: negatively_regulates GO:0048327 ! axial mesodermal cell fate specification [Term] id: GO:0048330 name: positive regulation of axial mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] synonym: "activation of axial mesodermal cell fate specification" NARROW [] synonym: "stimulation of axial mesodermal cell fate specification" NARROW [] synonym: "up regulation of axial mesodermal cell fate specification" EXACT [] synonym: "up-regulation of axial mesodermal cell fate specification" EXACT [] synonym: "upregulation of axial mesodermal cell fate specification" EXACT [] is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification relationship: positively_regulates GO:0048327 ! axial mesodermal cell fate specification [Term] id: GO:0048331 name: axial mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] synonym: "axial mesoderm structural organisation" EXACT [GOC:curators] is_a: GO:0048338 ! mesoderm structural organization relationship: part_of GO:0048319 ! axial mesoderm morphogenesis [Term] id: GO:0048332 name: mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0048333 name: mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh] synonym: "mesoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001707 ! mesoderm formation [Term] id: GO:0048334 name: regulation of mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0010470 ! regulation of gastrulation is_a: GO:2000027 ! regulation of organ morphogenesis is_a: GO:2000380 ! regulation of mesoderm development relationship: regulates GO:0007500 ! mesodermal cell fate determination [Term] id: GO:0048335 name: negative regulation of mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] synonym: "down regulation of mesodermal cell fate determination" EXACT [] synonym: "down-regulation of mesodermal cell fate determination" EXACT [] synonym: "downregulation of mesodermal cell fate determination" EXACT [] synonym: "inhibition of mesodermal cell fate determination" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0048334 ! regulation of mesodermal cell fate determination relationship: negatively_regulates GO:0007500 ! mesodermal cell fate determination [Term] id: GO:0048336 name: positive regulation of mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] synonym: "activation of mesodermal cell fate determination" NARROW [] synonym: "stimulation of mesodermal cell fate determination" NARROW [] synonym: "up regulation of mesodermal cell fate determination" EXACT [] synonym: "up-regulation of mesodermal cell fate determination" EXACT [] synonym: "upregulation of mesodermal cell fate determination" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0048334 ! regulation of mesodermal cell fate determination relationship: positively_regulates GO:0007500 ! mesodermal cell fate determination [Term] id: GO:0048337 name: positive regulation of mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification." [GOC:dgh] synonym: "activation of mesodermal cell fate specification" NARROW [] synonym: "stimulation of mesodermal cell fate specification" NARROW [] synonym: "up regulation of mesodermal cell fate specification" EXACT [] synonym: "up-regulation of mesodermal cell fate specification" EXACT [] synonym: "upregulation of mesodermal cell fate specification" EXACT [] is_a: GO:0042660 ! positive regulation of cell fate specification is_a: GO:0042661 ! regulation of mesodermal cell fate specification relationship: positively_regulates GO:0007501 ! mesodermal cell fate specification [Term] id: GO:0048338 name: mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] synonym: "mesoderm structural organisation" EXACT [GOC:curators] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048332 ! mesoderm morphogenesis [Term] id: GO:0048339 name: paraxial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh] is_a: GO:0007498 ! mesoderm development [Term] id: GO:0048340 name: paraxial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis relationship: part_of GO:0048339 ! paraxial mesoderm development [Term] id: GO:0048341 name: paraxial mesoderm formation namespace: biological_process def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] is_a: GO:0001707 ! mesoderm formation relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis [Term] id: GO:0048342 name: paraxial mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell." [GOC:dgh] is_a: GO:0048333 ! mesodermal cell differentiation relationship: part_of GO:0048341 ! paraxial mesoderm formation [Term] id: GO:0048343 name: paraxial mesodermal cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a paraxial mesoderm cell." [GOC:dgh] is_a: GO:0001710 ! mesodermal cell fate commitment relationship: part_of GO:0048342 ! paraxial mesodermal cell differentiation [Term] id: GO:0048344 name: paraxial mesodermal cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] is_a: GO:0007500 ! mesodermal cell fate determination relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment [Term] id: GO:0048345 name: regulation of paraxial mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] is_a: GO:0048334 ! regulation of mesodermal cell fate determination relationship: regulates GO:0048344 ! paraxial mesodermal cell fate determination [Term] id: GO:0048346 name: positive regulation of paraxial mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] synonym: "activation of paraxial mesodermal cell fate determination" NARROW [] synonym: "stimulation of paraxial mesodermal cell fate determination" NARROW [] synonym: "up regulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "up-regulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "upregulation of paraxial mesodermal cell fate determination" EXACT [] is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination relationship: positively_regulates GO:0048344 ! paraxial mesodermal cell fate determination [Term] id: GO:0048347 name: negative regulation of paraxial mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] synonym: "down regulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "down-regulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "downregulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "inhibition of paraxial mesodermal cell fate determination" NARROW [] is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination relationship: negatively_regulates GO:0048344 ! paraxial mesodermal cell fate determination [Term] id: GO:0048348 name: paraxial mesodermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] is_a: GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment [Term] id: GO:0048349 name: regulation of paraxial mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] is_a: GO:0042661 ! regulation of mesodermal cell fate specification relationship: regulates GO:0048348 ! paraxial mesodermal cell fate specification [Term] id: GO:0048350 name: positive regulation of paraxial mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] synonym: "activation of paraxial mesodermal cell fate specification" NARROW [] synonym: "stimulation of paraxial mesodermal cell fate specification" NARROW [] synonym: "up regulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "up-regulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "upregulation of paraxial mesodermal cell fate specification" EXACT [] is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification relationship: positively_regulates GO:0048348 ! paraxial mesodermal cell fate specification [Term] id: GO:0048351 name: negative regulation of paraxial mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] synonym: "down regulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "down-regulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "downregulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "inhibition of paraxial mesodermal cell fate specification" NARROW [] is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification relationship: negatively_regulates GO:0048348 ! paraxial mesodermal cell fate specification [Term] id: GO:0048352 name: paraxial mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] synonym: "paraxial mesoderm structural organisation" EXACT [GOC:curators] is_a: GO:0048338 ! mesoderm structural organization relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis [Term] id: GO:0048353 name: primary endosperm nucleus namespace: cellular_component def: "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac." [ISBN:0471245208] is_a: GO:0005634 ! nucleus [Term] id: GO:0048354 name: mucilage biosynthetic process involved in seed coat development namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb] synonym: "mucilage anabolism during seed coat development" EXACT [] synonym: "mucilage biosynthetic process during seed coat development" RELATED [GOC:dph, GOC:tb] synonym: "mucilage formation during seed coat development" EXACT [] synonym: "mucilage synthesis during seed coat development" EXACT [] is_a: GO:0010192 ! mucilage biosynthetic process is_a: GO:0048359 ! mucilage metabolic process involved seed coat development [Term] id: GO:0048355 name: root cap mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid] synonym: "root cap mucilage anabolism" EXACT [] synonym: "root cap mucilage biosynthesis" EXACT [] synonym: "root cap mucilage formation" EXACT [] synonym: "root cap mucilage synthesis" EXACT [] is_a: GO:0010192 ! mucilage biosynthetic process relationship: part_of GO:0048360 ! root cap mucilage metabolic process [Term] id: GO:0048356 name: root epithelial mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid] synonym: "root epithelial mucilage anabolism" EXACT [] synonym: "root epithelial mucilage biosynthesis" EXACT [] synonym: "root epithelial mucilage formation" EXACT [] synonym: "root epithelial mucilage synthesis" EXACT [] is_a: GO:0010192 ! mucilage biosynthetic process relationship: part_of GO:0048361 ! root epithelial mucilage metabolic process [Term] id: GO:0048357 name: pedicel mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem." [GOC:jid] synonym: "pedicel mucilage anabolism" EXACT [] synonym: "pedicel mucilage biosynthesis" EXACT [] synonym: "pedicel mucilage formation" EXACT [] synonym: "pedicel mucilage synthesis" EXACT [] is_a: GO:0010192 ! mucilage biosynthetic process relationship: part_of GO:0048362 ! pedicel mucilage metabolic process [Term] id: GO:0048358 name: mucilage pectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pectin component of mucilage." [GOC:jid] synonym: "mucilage pectin anabolism" EXACT [] synonym: "mucilage pectin biosynthesis" EXACT [] synonym: "mucilage pectin formation" EXACT [] synonym: "mucilage pectin synthesis" EXACT [] is_a: GO:0045489 ! pectin biosynthetic process is_a: GO:0048363 ! mucilage pectin metabolic process relationship: part_of GO:0010192 ! mucilage biosynthetic process [Term] id: GO:0048359 name: mucilage metabolic process involved seed coat development namespace: biological_process def: "The chemical reactions and pathways involving mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb] synonym: "mucilage metabolic process during seed coat development" RELATED [GOC:dph, GOC:tb] synonym: "mucilage metabolism during seed coat development" EXACT [] is_a: GO:0010191 ! mucilage metabolic process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0010214 ! seed coat development [Term] id: GO:0048360 name: root cap mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid] synonym: "root cap mucilage metabolism" EXACT [] is_a: GO:0010191 ! mucilage metabolic process [Term] id: GO:0048361 name: root epithelial mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid] synonym: "root epithelial mucilage metabolism" EXACT [] is_a: GO:0010191 ! mucilage metabolic process [Term] id: GO:0048362 name: pedicel mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage that occur in the flower stem." [GOC:jid] synonym: "pedicel mucilage metabolism" EXACT [] is_a: GO:0010191 ! mucilage metabolic process [Term] id: GO:0048363 name: mucilage pectin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the pectin component of mucilage." [GOC:jid] synonym: "mucilage pectin metabolism" EXACT [] is_a: GO:0045488 ! pectin metabolic process relationship: part_of GO:0010191 ! mucilage metabolic process [Term] id: GO:0048364 name: root development namespace: biological_process def: "The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo." [GOC:jid, PO:0009005] is_a: GO:0048513 ! organ development relationship: part_of GO:0022622 ! root system development [Term] id: GO:0048365 name: Rac GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases." [GOC:ebc, PMID:11702775] is_a: GO:0017048 ! Rho GTPase binding [Term] id: GO:0048366 name: leaf development namespace: biological_process def: "The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048827 ! phyllome development [Term] id: GO:0048367 name: shoot development namespace: biological_process def: "The process whose specific outcome is the progression of the shoot over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048513 ! organ development relationship: part_of GO:0022621 ! shoot system development [Term] id: GO:0048368 name: lateral mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators] synonym: "lateral plate mesoderm development" EXACT [] is_a: GO:0007498 ! mesoderm development [Term] id: GO:0048369 name: lateral mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators] synonym: "lateral plate mesoderm morphogenesis" EXACT [] is_a: GO:0048332 ! mesoderm morphogenesis relationship: part_of GO:0048368 ! lateral mesoderm development [Term] id: GO:0048370 name: lateral mesoderm formation namespace: biological_process def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid] synonym: "lateral plate mesoderm biosynthesis" EXACT [] synonym: "lateral plate mesoderm formation" EXACT [] is_a: GO:0001707 ! mesoderm formation relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis [Term] id: GO:0048371 name: lateral mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell." [GOC:jid] synonym: "lateral mesoderm cell differentiation" EXACT [] synonym: "lateral plate mesoderm cell differentiation" EXACT [] synonym: "lateral plate mesodermal cell differentiation" EXACT [] is_a: GO:0048333 ! mesodermal cell differentiation relationship: part_of GO:0048370 ! lateral mesoderm formation [Term] id: GO:0048372 name: lateral mesodermal cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a lateral mesoderm cell." [GOC:jid] synonym: "lateral mesoderm cell fate commitment" EXACT [] synonym: "lateral plate mesoderm cell fate commitment" EXACT [] synonym: "lateral plate mesodermal cell fate commitment" EXACT [] is_a: GO:0001710 ! mesodermal cell fate commitment relationship: part_of GO:0048371 ! lateral mesodermal cell differentiation [Term] id: GO:0048373 name: lateral mesodermal cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:jid] synonym: "lateral mesoderm cell fate determination" EXACT [] synonym: "lateral plate mesoderm cell fate determination" EXACT [] synonym: "lateral plate mesodermal cell fate determination" EXACT [] is_a: GO:0007500 ! mesodermal cell fate determination relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment [Term] id: GO:0048374 name: regulation of lateral mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid] synonym: "regulation of lateral mesoderm cell fate determination" EXACT [] synonym: "regulation of lateral plate mesoderm cell fate determination" EXACT [] synonym: "regulation of lateral plate mesodermal cell fate determination" EXACT [] is_a: GO:0048334 ! regulation of mesodermal cell fate determination relationship: regulates GO:0048373 ! lateral mesodermal cell fate determination [Term] id: GO:0048375 name: negative regulation of lateral mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid] synonym: "down regulation of lateral mesodermal cell fate determination" EXACT [] synonym: "down-regulation of lateral mesodermal cell fate determination" EXACT [] synonym: "downregulation of lateral mesodermal cell fate determination" EXACT [] synonym: "inhibition of lateral mesodermal cell fate determination" NARROW [] synonym: "negative regulation of lateral plate mesodermal cell fate determination" EXACT [] is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination relationship: negatively_regulates GO:0048373 ! lateral mesodermal cell fate determination [Term] id: GO:0048376 name: positive regulation of lateral mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid] synonym: "activation of lateral mesodermal cell fate determination" NARROW [] synonym: "positive regulation of lateral plate mesodermal cell fate determination" EXACT [] synonym: "stimulation of lateral mesodermal cell fate determination" NARROW [] synonym: "up regulation of lateral mesodermal cell fate determination" EXACT [] synonym: "up-regulation of lateral mesodermal cell fate determination" EXACT [] synonym: "upregulation of lateral mesodermal cell fate determination" EXACT [] is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination relationship: positively_regulates GO:0048373 ! lateral mesodermal cell fate determination [Term] id: GO:0048377 name: lateral mesodermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:jid] synonym: "lateral mesoderm cell fate specification" EXACT [] synonym: "lateral plate mesoderm cell fate specification" EXACT [] synonym: "lateral plate mesodermal cell fate specification" EXACT [] is_a: GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment [Term] id: GO:0048378 name: regulation of lateral mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid] synonym: "regulation of lateral plate mesodermal cell fate specification" EXACT [] is_a: GO:0042661 ! regulation of mesodermal cell fate specification relationship: regulates GO:0048377 ! lateral mesodermal cell fate specification [Term] id: GO:0048379 name: positive regulation of lateral mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid] synonym: "activation of lateral mesodermal cell fate specification" NARROW [] synonym: "positive regulation of lateral plate mesodermal cell fate specification" EXACT [] synonym: "stimulation of lateral mesodermal cell fate specification" NARROW [] synonym: "up regulation of lateral mesodermal cell fate specification" EXACT [] synonym: "up-regulation of lateral mesodermal cell fate specification" EXACT [] synonym: "upregulation of lateral mesodermal cell fate specification" EXACT [] is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification relationship: positively_regulates GO:0048377 ! lateral mesodermal cell fate specification [Term] id: GO:0048380 name: negative regulation of lateral mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid] synonym: "down regulation of lateral mesodermal cell fate specification" EXACT [] synonym: "down-regulation of lateral mesodermal cell fate specification" EXACT [] synonym: "downregulation of lateral mesodermal cell fate specification" EXACT [] synonym: "inhibition of lateral mesodermal cell fate specification" NARROW [] synonym: "negative regulation of lateral plate mesodermal cell fate specification" EXACT [] is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification relationship: negatively_regulates GO:0048377 ! lateral mesodermal cell fate specification [Term] id: GO:0048381 name: lateral mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "lateral mesoderm structural organisation" EXACT [GOC:curators] synonym: "lateral plate mesoderm structural organization" EXACT [] is_a: GO:0048338 ! mesoderm structural organization relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis [Term] id: GO:0048382 name: mesendoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007492 ! endoderm development relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0048383 name: mesectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007398 ! ectoderm development relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0048384 name: retinoic acid receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands." [GOC:dgh] synonym: "RAR signaling pathway" EXACT [] synonym: "retinoic acid receptor signalling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0048385 name: regulation of retinoic acid receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] synonym: "regulation of RAR signaling pathway" EXACT [] synonym: "regulation of retinoic acid receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0048384 ! retinoic acid receptor signaling pathway [Term] id: GO:0048386 name: positive regulation of retinoic acid receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] synonym: "activation of retinoic acid receptor signaling pathway" NARROW [] synonym: "positive regulation of RAR signaling pathway" EXACT [] synonym: "positive regulation of retinoic acid receptor signalling pathway" EXACT [] synonym: "stimulation of retinoic acid receptor signaling pathway" NARROW [] synonym: "up regulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "up-regulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "upregulation of retinoic acid receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway relationship: positively_regulates GO:0048384 ! retinoic acid receptor signaling pathway [Term] id: GO:0048387 name: negative regulation of retinoic acid receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] synonym: "down regulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "down-regulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "downregulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "inhibition of retinoic acid receptor signaling pathway" NARROW [] synonym: "negative regulation of RAR signaling pathway" EXACT [] synonym: "negative regulation of RAR signalling pathway" EXACT [] synonym: "negative regulation of retinoic acid receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway relationship: negatively_regulates GO:0048384 ! retinoic acid receptor signaling pathway [Term] id: GO:0048388 name: endosomal lumen acidification namespace: biological_process def: "Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid] is_a: GO:0051452 ! intracellular pH reduction relationship: part_of GO:0007032 ! endosome organization [Term] id: GO:0048389 name: intermediate mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh] is_a: GO:0007498 ! mesoderm development [Term] id: GO:0048390 name: intermediate mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis relationship: part_of GO:0048389 ! intermediate mesoderm development [Term] id: GO:0048391 name: intermediate mesoderm formation namespace: biological_process def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] is_a: GO:0001707 ! mesoderm formation relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis [Term] id: GO:0048392 name: intermediate mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell." [GOC:dgh] synonym: "intermediate mesoderm cell differentiation" EXACT [] is_a: GO:0048333 ! mesodermal cell differentiation relationship: part_of GO:0048391 ! intermediate mesoderm formation [Term] id: GO:0048393 name: intermediate mesodermal cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell." [GOC:dgh] synonym: "intermediate mesoderm cell fate commitment" EXACT [] is_a: GO:0001710 ! mesodermal cell fate commitment relationship: part_of GO:0048392 ! intermediate mesodermal cell differentiation [Term] id: GO:0048394 name: intermediate mesodermal cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] synonym: "intermediate mesoderm cell fate determination" EXACT [] is_a: GO:0007500 ! mesodermal cell fate determination relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment [Term] id: GO:0048395 name: regulation of intermediate mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] is_a: GO:0048334 ! regulation of mesodermal cell fate determination relationship: regulates GO:0048394 ! intermediate mesodermal cell fate determination [Term] id: GO:0048396 name: negative regulation of intermediate mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] synonym: "down regulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "down-regulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "downregulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "inhibition of intermediate mesodermal cell fate determination" NARROW [] is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination relationship: negatively_regulates GO:0048394 ! intermediate mesodermal cell fate determination [Term] id: GO:0048397 name: positive regulation of intermediate mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] synonym: "activation of intermediate mesodermal cell fate determination" NARROW [] synonym: "stimulation of intermediate mesodermal cell fate determination" NARROW [] synonym: "up regulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "up-regulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "upregulation of intermediate mesodermal cell fate determination" EXACT [] is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination relationship: positively_regulates GO:0048394 ! intermediate mesodermal cell fate determination [Term] id: GO:0048398 name: intermediate mesodermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] synonym: "intermediate mesoderm cell fate specification" EXACT [] is_a: GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment [Term] id: GO:0048399 name: regulation of intermediate mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] is_a: GO:0042661 ! regulation of mesodermal cell fate specification relationship: regulates GO:0048398 ! intermediate mesodermal cell fate specification [Term] id: GO:0048400 name: positive regulation of intermediate mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] synonym: "activation of intermediate mesodermal cell fate specification" NARROW [] synonym: "stimulation of intermediate mesodermal cell fate specification" NARROW [] synonym: "up regulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "up-regulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "upregulation of intermediate mesodermal cell fate specification" EXACT [] is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification relationship: positively_regulates GO:0048398 ! intermediate mesodermal cell fate specification [Term] id: GO:0048401 name: negative regulation of intermediate mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] synonym: "down regulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "down-regulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "downregulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "inhibition of intermediate mesodermal cell fate specification" NARROW [] is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification relationship: negatively_regulates GO:0048398 ! intermediate mesodermal cell fate specification [Term] id: GO:0048402 name: intermediate mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] synonym: "intermediate mesoderm structural organisation" EXACT [GOC:curators] is_a: GO:0048338 ! mesoderm structural organization relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis [Term] id: GO:0048403 name: brain-derived neurotrophic factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with brain-derived neurotrophic factor." [GOC:dgh] synonym: "BDNF binding" EXACT [] synonym: "neurotrophin TRKB receptor activity" RELATED [] is_a: GO:0043121 ! neurotrophin binding [Term] id: GO:0048404 name: neurotrophin-3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with neurotrophin-3." [GOC:dgh] synonym: "neurotrophin 3 binding" EXACT [] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "neurotrophin TRKC receptor activity" RELATED [] synonym: "NT-3 binding" EXACT [] synonym: "NT3 binding" EXACT [] is_a: GO:0043121 ! neurotrophin binding [Term] id: GO:0048405 name: neurotrophin-4/5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with neurotrophin-4/5." [GOC:dgh] comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858]. synonym: "neurotrophin 4/5 binding" EXACT [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "NT 4/5 binding" EXACT [] synonym: "NT-4 binding" NARROW [] synonym: "NT-4/5 binding" EXACT [] synonym: "NT-5 binding" NARROW [] synonym: "NT4 binding" NARROW [] synonym: "NT5 binding" NARROW [] is_a: GO:0043121 ! neurotrophin binding [Term] id: GO:0048406 name: nerve growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with nerve growth factor." [GOC:dgh] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "NGF binding" EXACT [] is_a: GO:0043121 ! neurotrophin binding [Term] id: GO:0048407 name: platelet-derived growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with platelet-derived growth factor." [GOC:dgh] synonym: "PDGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0048408 name: epidermal growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with epidermal growth factor." [GOC:dgh] synonym: "EGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0048437 name: floral organ development namespace: biological_process alt_id: GO:0048433 def: "The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0009908 ! flower development [Term] id: GO:0048438 name: floral whorl development namespace: biological_process alt_id: GO:0048413 def: "The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant." [GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0009908 ! flower development [Term] id: GO:0048439 name: flower morphogenesis namespace: biological_process alt_id: GO:0048411 def: "The process in which the anatomical structures of the flower are generated and organized." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0009908 ! flower development [Term] id: GO:0048440 name: carpel development namespace: biological_process alt_id: GO:0048429 def: "The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style." [GOC:go_curators] is_a: GO:0048437 ! floral organ development relationship: part_of GO:0048467 ! gynoecium development [Term] id: GO:0048441 name: petal development namespace: biological_process alt_id: GO:0048417 def: "The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048437 ! floral organ development relationship: part_of GO:0048465 ! corolla development [Term] id: GO:0048442 name: sepal development namespace: biological_process alt_id: GO:0048421 def: "The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048437 ! floral organ development relationship: part_of GO:0048464 ! flower calyx development [Term] id: GO:0048443 name: stamen development namespace: biological_process alt_id: GO:0048425 def: "The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048437 ! floral organ development relationship: part_of GO:0048466 ! androecium development [Term] id: GO:0048444 name: floral organ morphogenesis namespace: biological_process alt_id: GO:0048434 def: "The process in which the anatomical structures of the floral organ are generated and organized." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048563 ! post-embryonic organ morphogenesis relationship: part_of GO:0048437 ! floral organ development [Term] id: GO:0048445 name: carpel morphogenesis namespace: biological_process alt_id: GO:0048430 def: "The process in which the anatomical structures of the carpel are generated and organized." [GOC:go_curators] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048440 ! carpel development [Term] id: GO:0048446 name: petal morphogenesis namespace: biological_process alt_id: GO:0048418 def: "The process in which the anatomical structures of the petal are generated and organized." [GOC:go_curators] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048441 ! petal development [Term] id: GO:0048447 name: sepal morphogenesis namespace: biological_process alt_id: GO:0048422 def: "The process in which the anatomical structures of the sepal are generated and organized." [GOC:go_curators] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048442 ! sepal development [Term] id: GO:0048448 name: stamen morphogenesis namespace: biological_process alt_id: GO:0048426 def: "The process in which the anatomical structures of the stamen are generated and organized." [GOC:go_curators] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048443 ! stamen development [Term] id: GO:0048449 name: floral organ formation namespace: biological_process alt_id: GO:0048436 def: "The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048645 ! organ formation relationship: part_of GO:0048444 ! floral organ morphogenesis [Term] id: GO:0048450 name: floral organ structural organization namespace: biological_process alt_id: GO:0048435 def: "The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "floral organ structural organisation" EXACT [GOC:curators] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048461 ! flower structural organization [Term] id: GO:0048451 name: petal formation namespace: biological_process alt_id: GO:0048419 def: "The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0048449 ! floral organ formation relationship: part_of GO:0048446 ! petal morphogenesis [Term] id: GO:0048452 name: petal structural organization namespace: biological_process alt_id: GO:0048420 def: "The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "petal structural organisation" EXACT [GOC:curators] is_a: GO:0048450 ! floral organ structural organization relationship: part_of GO:0048446 ! petal morphogenesis [Term] id: GO:0048453 name: sepal formation namespace: biological_process alt_id: GO:0048423 def: "The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0048449 ! floral organ formation relationship: part_of GO:0048447 ! sepal morphogenesis [Term] id: GO:0048454 name: sepal structural organization namespace: biological_process alt_id: GO:0048424 def: "The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "sepal structural organisation" EXACT [GOC:curators] is_a: GO:0048450 ! floral organ structural organization relationship: part_of GO:0048447 ! sepal morphogenesis [Term] id: GO:0048455 name: stamen formation namespace: biological_process alt_id: GO:0048427 def: "The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0048449 ! floral organ formation relationship: part_of GO:0048448 ! stamen morphogenesis [Term] id: GO:0048456 name: stamen structural organization namespace: biological_process alt_id: GO:0048428 def: "The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "stamen structural organisation" EXACT [GOC:curators] is_a: GO:0048450 ! floral organ structural organization relationship: part_of GO:0048448 ! stamen morphogenesis [Term] id: GO:0048457 name: floral whorl morphogenesis namespace: biological_process alt_id: GO:0048414 def: "The process in which the anatomical structures of the floral whorl are generated and organized." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0048438 ! floral whorl development relationship: part_of GO:0048439 ! flower morphogenesis [Term] id: GO:0048458 name: floral whorl formation namespace: biological_process alt_id: GO:0048415 def: "The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048457 ! floral whorl morphogenesis [Term] id: GO:0048459 name: floral whorl structural organization namespace: biological_process alt_id: GO:0048416 def: "The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "floral whorl structural organisation" EXACT [GOC:curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048457 ! floral whorl morphogenesis relationship: part_of GO:0048461 ! flower structural organization [Term] id: GO:0048460 name: flower formation namespace: biological_process alt_id: GO:0048410 def: "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048439 ! flower morphogenesis [Term] id: GO:0048461 name: flower structural organization namespace: biological_process alt_id: GO:0048412 def: "The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "flower structural organisation" EXACT [GOC:curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048439 ! flower morphogenesis [Term] id: GO:0048462 name: carpel formation namespace: biological_process alt_id: GO:0048431 def: "The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0048449 ! floral organ formation relationship: part_of GO:0048445 ! carpel morphogenesis [Term] id: GO:0048463 name: carpel structural organization namespace: biological_process alt_id: GO:0048432 def: "The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "carpel structural organisation" EXACT [GOC:curators] is_a: GO:0048450 ! floral organ structural organization relationship: part_of GO:0048445 ! carpel morphogenesis [Term] id: GO:0048464 name: flower calyx development namespace: biological_process def: "The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048438 ! floral whorl development [Term] id: GO:0048465 name: corolla development namespace: biological_process def: "The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048438 ! floral whorl development [Term] id: GO:0048466 name: androecium development namespace: biological_process def: "The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048438 ! floral whorl development [Term] id: GO:0048467 name: gynoecium development namespace: biological_process def: "The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower." [GOC:go_curators, PO:0008062] synonym: "pistil development" EXACT [] is_a: GO:0048438 ! floral whorl development [Term] id: GO:0048468 name: cell development namespace: biological_process def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators] subset: goslim_candida subset: gosubset_prok synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0030154 ! cell differentiation [Term] id: GO:0048469 name: cell maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "functional differentiation" RELATED [GOC:dph] is_a: GO:0021700 ! developmental maturation is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0048468 ! cell development [Term] id: GO:0048471 name: perinuclear region of cytoplasm namespace: cellular_component def: "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] comment: Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'. is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0048472 name: threonine-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-threonine + H(+) = (R)-1-aminopropan-2-yl phosphate + CO(2)." [EC:4.1.1.81, RHEA:11495] subset: gosubset_prok synonym: "CobD" RELATED [EC:4.1.1.81] synonym: "L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]" RELATED [EC:4.1.1.81] synonym: "L-threonine O-3-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.81] synonym: "L-threonine-O-3-phosphate decarboxylase activity" EXACT [] xref: EC:4.1.1.81 xref: KEGG:R06530 xref: MetaCyc:4.1.1.81-RXN xref: RHEA:11495 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0048473 name: D-methionine transport namespace: biological_process def: "The directed movement of D-methionine into, out of, within, or between cells." [GOC:mlg, PMID:12169620] subset: gosubset_prok is_a: GO:0015821 ! methionine transport [Term] id: GO:0048474 name: D-methionine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of D-methionine from one side of a membrane to the other." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "D-methionine transporter activity" BROAD [] is_a: GO:0043865 ! methionine transmembrane transporter activity [Term] id: GO:0048475 name: coated membrane namespace: cellular_component def: "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid] is_a: GO:0016020 ! membrane [Term] id: GO:0048476 name: Holliday junction resolvase complex namespace: cellular_component def: "A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage." [PMID:11207366, PMID:12374758] subset: goslim_pir synonym: "Mus81-Eme1 complex" NARROW [] synonym: "resolvasome" EXACT [PMID:11207366] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0048477 name: oogenesis namespace: biological_process alt_id: GO:0009993 alt_id: GO:0048157 def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu] synonym: "ovum development" EXACT systematic_synonym [] xref: Wikipedia:Oogenesis is_a: GO:0007292 ! female gamete generation [Term] id: GO:0048478 name: replication fork protection namespace: biological_process def: "Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029] synonym: "replication fork maintenance" BROAD [] synonym: "replication fork stabilization" BROAD [] is_a: GO:0045005 ! maintenance of fidelity involved in DNA-dependent DNA replication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication [Term] id: GO:0048479 name: style development namespace: biological_process def: "The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma." [GOC:jid, PO:0009074] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048440 ! carpel development [Term] id: GO:0048480 name: stigma development namespace: biological_process def: "The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky." [GOC:jid, PO:0009073] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048440 ! carpel development [Term] id: GO:0048481 name: ovule development namespace: biological_process def: "The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035670 ! ovule-producing ovary development [Term] id: GO:0048482 name: ovule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ovule are generated and organized. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0048445 ! carpel morphogenesis relationship: part_of GO:0048481 ! ovule development [Term] id: GO:0048483 name: autonomic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0048484 name: enteric nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation." [FMA:66070, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development relationship: part_of GO:0048483 ! autonomic nervous system development [Term] id: GO:0048485 name: sympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development relationship: part_of GO:0048483 ! autonomic nervous system development [Term] id: GO:0048486 name: parasympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [FMA:9907, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development relationship: part_of GO:0048483 ! autonomic nervous system development [Term] id: GO:0048487 name: beta-tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin." [GOC:krc] synonym: "beta tubulin binding" EXACT [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0048488 name: synaptic vesicle endocytosis namespace: biological_process alt_id: GO:0008099 def: "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] subset: gosubset_prok synonym: "synaptic vesicle retrieval" RELATED [] is_a: GO:0006897 ! endocytosis is_a: GO:0048489 ! synaptic vesicle transport [Term] id: GO:0048489 name: synaptic vesicle transport namespace: biological_process alt_id: GO:0016181 def: "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg] subset: gosubset_prok synonym: "synaptic vesicle fission" RELATED [] synonym: "synaptic vesicle fusion" RELATED [] is_a: GO:0016192 ! vesicle-mediated transport relationship: part_of GO:0007268 ! synaptic transmission [Term] id: GO:0048490 name: anterograde synaptic vesicle transport namespace: biological_process def: "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, away from the neuronal cell body." [GOC:jid, GOC:lmg] is_a: GO:0048489 ! synaptic vesicle transport [Term] id: GO:0048491 name: retrograde synaptic vesicle transport namespace: biological_process def: "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, toward the neuronal cell body." [GOC:jid, GOC:lmg] is_a: GO:0048489 ! synaptic vesicle transport [Term] id: GO:0048492 name: ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg] subset: goslim_pir subset: gosubset_prok synonym: "RubisCO complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0048493 name: plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "plasma membrane ribulose bisphosphate carboxylase complex" EXACT [] synonym: "ribulose bisphosphate carboxylase complex" BROAD [] synonym: "RubisCO complex" BROAD [] is_a: GO:0044422 ! organelle part is_a: GO:0044436 ! thylakoid part is_a: GO:0044459 ! plasma membrane part is_a: GO:0048494 ! chromatophore ribulose bisphosphate carboxylase complex relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid [Term] id: GO:0048494 name: chromatophore ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok synonym: "RubisCO complex" BROAD [] is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0048495 name: Roundabout binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor." [GOC:ecd, PMID:10102268, PMID:10197527] synonym: "Roundabout receptor binding" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0048496 name: maintenance of organ identity namespace: biological_process def: "The process in which the identity of an organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators, PMID:9090883] is_a: GO:0045596 ! negative regulation of cell differentiation relationship: part_of GO:0048513 ! organ development [Term] id: GO:0048497 name: maintenance of floral organ identity namespace: biological_process def: "The process in which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators, PMID:9090883] is_a: GO:0048496 ! maintenance of organ identity relationship: part_of GO:0048437 ! floral organ development [Term] id: GO:0048498 name: establishment of petal orientation namespace: biological_process def: "The process that determines the orientation of petals with reference to the central axis." [GOC:tb, PMID:10572040] is_a: GO:0048559 ! establishment of floral organ orientation relationship: part_of GO:0048446 ! petal morphogenesis [Term] id: GO:0048499 name: synaptic vesicle membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806] synonym: "SLMV biogenesis" NARROW [] synonym: "synaptic vesicle membrane organisation" EXACT [GOC:curators] synonym: "synaptic vesicle membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0048500 name: signal recognition particle namespace: cellular_component def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Signal_recognition_particle is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0048501 name: signal recognition particle, plasma membrane targeting namespace: cellular_component def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane." [GOC:mlg, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0048500 ! signal recognition particle [Term] id: GO:0048502 name: thiamine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + thiamine(out) = ADP + phosphate + thiamine(in)." [GOC:mlg, PMID:9535878] synonym: "thiamin-transporting ATPase activity" EXACT [GOC:curators] synonym: "thiamine ABC transporter" NARROW [] is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0048503 name: GPI anchor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw] comment: This term was made obsolete because it has been widely, and incorrectly, used to annotate proteins that have GPI anchors covalently attached. A new term has been created that can be used to annotate gene products that interact non-covalently with GPI anchors. synonym: "glycosylphosphatidylinositol binding" EXACT [] is_obsolete: true [Term] id: GO:0048504 name: regulation of timing of organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of organ formation at a consistent predetermined time point during development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] synonym: "timing of organ biosynthesis" RELATED [] synonym: "timing of organ formation" RELATED [] is_a: GO:0003156 ! regulation of organ formation is_a: GO:0040034 ! regulation of development, heterochronic [Term] id: GO:0048505 name: regulation of timing of cell differentiation namespace: biological_process def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] synonym: "timing of cell differentiation" RELATED [] is_a: GO:0040034 ! regulation of development, heterochronic is_a: GO:0045595 ! regulation of cell differentiation [Term] id: GO:0048506 name: regulation of timing of meristematic phase transition namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a change in identity of a meristem at a characteristic predetermined time point." [GOC:dph, GOC:jid, GOC:tb] is_a: GO:0040034 ! regulation of development, heterochronic is_a: GO:0048509 ! regulation of meristem development [Term] id: GO:0048507 name: meristem development namespace: biological_process def: "The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0048508 name: embryonic meristem development namespace: biological_process def: "The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048507 ! meristem development relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0048509 name: regulation of meristem development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0048507 ! meristem development [Term] id: GO:0048510 name: regulation of timing of transition from vegetative to reproductive phase namespace: biological_process def: "The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs." [GOC:jid, PMID:8974397] is_a: GO:0048506 ! regulation of timing of meristematic phase transition [Term] id: GO:0048511 name: rhythmic process namespace: biological_process def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] subset: goslim_pir subset: gosubset_prok synonym: "rhythm" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0048512 name: circadian behavior namespace: biological_process def: "The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] synonym: "circadian rhythm behavior" EXACT [] is_a: GO:0007622 ! rhythmic behavior is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0048513 name: organ development namespace: biological_process def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] synonym: "development of an organ" EXACT [] synonym: "organogenesis" EXACT [] xref: Wikipedia:Organogenesis is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048731 ! system development [Term] id: GO:0048514 name: blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0048515 name: spermatid differentiation namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] synonym: "spermatid cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048516 name: trichome initiation (sensu Magnoliophyta) namespace: biological_process def: "OBSOLETE. Processes causing the differentiation of an epidermal cell into a trichome cell; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr] comment: This term was made obsolete because more appropriate terms were created. is_obsolete: true consider: GO:0048629 [Term] id: GO:0048517 name: positive regulation of trichome initiation (sensu Magnoliophyta) namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of trichome initiation; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr] comment: This term was made obsolete because more appropriate terms were created. is_obsolete: true consider: GO:0048629 [Term] id: GO:0048518 name: positive regulation of biological process namespace: biological_process alt_id: GO:0043119 def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gosubset_prok synonym: "activation of biological process" NARROW [] synonym: "positive regulation of physiological process" EXACT [] synonym: "stimulation of biological process" NARROW [] synonym: "up regulation of biological process" EXACT [] synonym: "up-regulation of biological process" EXACT [] synonym: "upregulation of biological process" EXACT [] is_a: GO:0050789 ! regulation of biological process relationship: positively_regulates GO:0008150 ! biological_process [Term] id: GO:0048519 name: negative regulation of biological process namespace: biological_process alt_id: GO:0043118 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gosubset_prok synonym: "down regulation of biological process" EXACT [] synonym: "down-regulation of biological process" EXACT [] synonym: "downregulation of biological process" EXACT [] synonym: "inhibition of biological process" NARROW [] synonym: "negative regulation of physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process relationship: negatively_regulates GO:0008150 ! biological_process [Term] id: GO:0048520 name: positive regulation of behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GOC:jid] synonym: "activation of behavior" NARROW [] synonym: "stimulation of behavior" NARROW [] synonym: "up regulation of behavior" EXACT [] synonym: "up-regulation of behavior" EXACT [] synonym: "upregulation of behavior" EXACT [] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior relationship: positively_regulates GO:0007610 ! behavior [Term] id: GO:0048521 name: negative regulation of behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GOC:jid] synonym: "down regulation of behavior" EXACT [] synonym: "down-regulation of behavior" EXACT [] synonym: "downregulation of behavior" EXACT [] synonym: "inhibition of behavior" NARROW [] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior relationship: negatively_regulates GO:0007610 ! behavior [Term] id: GO:0048522 name: positive regulation of cellular process namespace: biological_process alt_id: GO:0051242 def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gosubset_prok synonym: "activation of cellular process" NARROW [] synonym: "positive regulation of cellular physiological process" EXACT [] synonym: "stimulation of cellular process" NARROW [] synonym: "up regulation of cellular process" EXACT [] synonym: "up-regulation of cellular process" EXACT [] synonym: "upregulation of cellular process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process relationship: positively_regulates GO:0009987 ! cellular process [Term] id: GO:0048523 name: negative regulation of cellular process namespace: biological_process alt_id: GO:0051243 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gosubset_prok synonym: "down regulation of cellular process" EXACT [] synonym: "down-regulation of cellular process" EXACT [] synonym: "downregulation of cellular process" EXACT [] synonym: "inhibition of cellular process" NARROW [] synonym: "negative regulation of cellular physiological process" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process relationship: negatively_regulates GO:0009987 ! cellular process [Term] id: GO:0048524 name: positive regulation of viral reproduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:jid, GOC:tb] synonym: "activation of viral life cycle" NARROW [] synonym: "positive regulation of viral life cycle" EXACT [GOC:tb] synonym: "stimulation of viral life cycle" NARROW [] synonym: "up regulation of viral life cycle" EXACT [] synonym: "up-regulation of viral life cycle" EXACT [] synonym: "upregulation of viral life cycle" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050792 ! regulation of viral reproduction relationship: positively_regulates GO:0016032 ! viral reproduction [Term] id: GO:0048525 name: negative regulation of viral reproduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:jid, GOC:tb] synonym: "down regulation of viral life cycle" EXACT [] synonym: "down-regulation of viral life cycle" EXACT [] synonym: "downregulation of viral life cycle" EXACT [] synonym: "inhibition of viral life cycle" NARROW [] synonym: "negative regulation of viral life cycle" EXACT [GOC:tb] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050792 ! regulation of viral reproduction relationship: negatively_regulates GO:0016032 ! viral reproduction [Term] id: GO:0048526 name: imaginal disc-derived wing expansion namespace: biological_process def: "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc] synonym: "wing expansion" EXACT [] synonym: "wing inflation" EXACT [] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0048527 name: lateral root development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tb] is_a: GO:0048528 ! post-embryonic root development [Term] id: GO:0048528 name: post-embryonic root development namespace: biological_process def: "The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0009791 ! post-embryonic development is_a: GO:0048364 ! root development is_a: GO:0048569 ! post-embryonic organ development [Term] id: GO:0048529 name: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity namespace: molecular_function def: "Catalysis of the reaction: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O." [EC:1.14.13.81] synonym: "magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.81] synonym: "Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity" EXACT [EC:1.14.13.81] synonym: "Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity" EXACT [EC:1.14.13.81] xref: EC:1.14.13.81 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0048530 name: fruit morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a fruit are generated and organized. A fruit is a reproductive body of a seed plant." [GOC:sm] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0010154 ! fruit development [Term] id: GO:0048531 name: beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage." [PMID:11551958] is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0048532 name: anatomical structure arrangement namespace: biological_process def: "The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:go_curators] synonym: "anatomical structure organization" BROAD [] synonym: "anatomical structure structural organization" EXACT [] synonym: "organization of an anatomical structure" EXACT [] synonym: "structural organization" EXACT [] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048533 name: sporocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores." [GOC:tair_curators] synonym: "sporocyte development" NARROW [] synonym: "sporocyte morphogenesis" RELATED [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048534 name: hemopoietic or lymphoid organ development namespace: biological_process def: "The process whose specific outcome is the progression of any organ involved in hemopoiesis or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "haematopoietic or lymphoid organ development" EXACT [] synonym: "haemopoietic or lymphoid organ development" EXACT [] synonym: "hematopoietic or lymphoid organ development" EXACT [] is_a: GO:0048513 ! organ development relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0048535 name: lymph node development namespace: biological_process def: "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"] synonym: "lymph gland development" BROAD [] is_a: GO:0048534 ! hemopoietic or lymphoid organ development [Term] id: GO:0048536 name: spleen development namespace: biological_process def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0048534 ! hemopoietic or lymphoid organ development [Term] id: GO:0048537 name: mucosal-associated lymphoid tissue development namespace: biological_process def: "The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "BALT development" NARROW [] synonym: "bronchial-associated lymphoid tissue development" NARROW [] synonym: "GALT development" NARROW [] synonym: "gut-associated lymphoid tissue development" NARROW [] synonym: "NALT development" NARROW [] synonym: "nasopharyngeal-associated lymphoid tissue development" NARROW [] is_a: GO:0048534 ! hemopoietic or lymphoid organ development [Term] id: GO:0048538 name: thymus development namespace: biological_process def: "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere. is_a: GO:0048534 ! hemopoietic or lymphoid organ development [Term] id: GO:0048539 name: bone marrow development namespace: biological_process def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0048534 ! hemopoietic or lymphoid organ development relationship: part_of GO:0060348 ! bone development [Term] id: GO:0048540 name: bursa of Fabricius development namespace: biological_process def: "The process whose specific outcome is the progression of the bursa of Fabricius over time, from its formation to the mature structure. The bursa of Fabricius is an organ found in birds involved in B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0048534 ! hemopoietic or lymphoid organ development [Term] id: GO:0048541 name: Peyer's patch development namespace: biological_process def: "The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "GALT development" RELATED [] synonym: "gut-associated lymphoid tissue development" RELATED [] is_a: GO:0048537 ! mucosal-associated lymphoid tissue development [Term] id: GO:0048542 name: lymph gland development namespace: biological_process def: "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] synonym: "haematopoietic organ development" BROAD [] synonym: "haemopoietic organ development" BROAD [] synonym: "hematopoietic organ development" BROAD [] synonym: "hemopoietic organ development" BROAD [] is_a: GO:0048534 ! hemopoietic or lymphoid organ development is_a: GO:0048732 ! gland development [Term] id: GO:0048543 name: phytochrome chromophore biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form." [GOC:pj, PMID:2909515] synonym: "phytochrome chromophore anabolism" EXACT [] synonym: "phytochrome chromophore biosynthesis" EXACT [] synonym: "phytochrome chromophore formation" EXACT [] synonym: "phytochrome chromophore synthesis" EXACT [] is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0048544 name: recognition of pollen namespace: biological_process alt_id: GO:0009857 def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species." [GOC:dph, GOC:pj, GOC:tb] synonym: "pollen recognition" EXACT [] synonym: "recognition or rejection of self pollen" RELATED [GOC:dph, GOC:tb] synonym: "self incompatibility" RELATED [] is_a: GO:0008037 ! cell recognition is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0048545 name: response to steroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0048546 name: digestive tract morphogenesis namespace: biological_process alt_id: GO:0048547 def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131] synonym: "alimentary canal morphogenesis" EXACT [] synonym: "digestive tube morphogenesis" EXACT [] synonym: "gastrointestinal tract morphogenesis" EXACT [] synonym: "gut morphogenesis" BROAD [GOC:dph] synonym: "intestinal morphogenesis" NARROW [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0048548 name: regulation of pinocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] is_a: GO:0030100 ! regulation of endocytosis relationship: regulates GO:0006907 ! pinocytosis [Term] id: GO:0048549 name: positive regulation of pinocytosis namespace: biological_process def: "Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] synonym: "activation of pinocytosis" NARROW [] synonym: "stimulation of pinocytosis" NARROW [] synonym: "up regulation of pinocytosis" EXACT [] synonym: "up-regulation of pinocytosis" EXACT [] synonym: "upregulation of pinocytosis" EXACT [] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:0048548 ! regulation of pinocytosis relationship: positively_regulates GO:0006907 ! pinocytosis [Term] id: GO:0048550 name: negative regulation of pinocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] synonym: "down regulation of pinocytosis" EXACT [] synonym: "down-regulation of pinocytosis" EXACT [] synonym: "downregulation of pinocytosis" EXACT [] synonym: "inhibition of pinocytosis" NARROW [] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:0048548 ! regulation of pinocytosis relationship: negatively_regulates GO:0006907 ! pinocytosis [Term] id: GO:0048551 name: metalloenzyme inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0010576 ! metalloenzyme regulator activity [Term] id: GO:0048552 name: regulation of metalloenzyme activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc] subset: gosubset_prok is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0048553 name: negative regulation of metalloenzyme activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc] synonym: "down regulation of metalloenzyme activity" EXACT [] synonym: "down-regulation of metalloenzyme activity" EXACT [] synonym: "downregulation of metalloenzyme activity" EXACT [] synonym: "inhibition of metalloenzyme activity" NARROW [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0048552 ! regulation of metalloenzyme activity [Term] id: GO:0048554 name: positive regulation of metalloenzyme activity namespace: biological_process def: "Any process that activates, maintains or increases the rate activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc] synonym: "activation of metalloenzyme activity" NARROW [] synonym: "stimulation of metalloenzyme activity" NARROW [] synonym: "up regulation of metalloenzyme activity" EXACT [] synonym: "up-regulation of metalloenzyme activity" EXACT [] synonym: "upregulation of metalloenzyme activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0048552 ! regulation of metalloenzyme activity [Term] id: GO:0048555 name: generative cell nucleus namespace: cellular_component def: "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells." [GOC:tair_curators] synonym: "male germ cell nucleus" BROAD [] synonym: "sperm cell nucleus" BROAD [] is_a: GO:0005634 ! nucleus [Term] id: GO:0048556 name: microsporocyte nucleus namespace: cellular_component alt_id: GO:0043074 def: "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte." [GOC:tair_curators, ISBN:047186840X] synonym: "microspore mother cell nucleus" EXACT [] synonym: "pollen mother cell nucleus" EXACT [] is_a: GO:0005634 ! nucleus [Term] id: GO:0048557 name: embryonic digestive tract morphogenesis namespace: biological_process alt_id: GO:0048558 def: "The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] synonym: "embryonic digestive tract morphogenesis" EXACT [] synonym: "embryonic gut morphogenesis" BROAD [GOC:dph] is_a: GO:0048562 ! embryonic organ morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis relationship: part_of GO:0048566 ! embryonic digestive tract development [Term] id: GO:0048559 name: establishment of floral organ orientation namespace: biological_process def: "The process that determines the orientation of the floral organs with reference to the central axis of the flower." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048561 ! establishment of organ orientation relationship: part_of GO:0048439 ! flower morphogenesis [Term] id: GO:0048560 name: establishment of anatomical structure orientation namespace: biological_process def: "The process that determines the orientation of an anatomical structure with reference to an axis." [GOC:jid] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048561 name: establishment of organ orientation namespace: biological_process def: "The process that determines the orientation of an organ or tissue with reference to an axis." [GOC:jid] is_a: GO:0048560 ! establishment of anatomical structure orientation relationship: part_of GO:0009887 ! organ morphogenesis [Term] id: GO:0048562 name: embryonic organ morphogenesis namespace: biological_process def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] is_a: GO:0009887 ! organ morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048568 ! embryonic organ development [Term] id: GO:0048563 name: post-embryonic organ morphogenesis namespace: biological_process def: "Morphogenesis, during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0048569 ! post-embryonic organ development [Term] id: GO:0048564 name: photosystem I assembly namespace: biological_process alt_id: GO:0010251 def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane." [GOC:go_curators] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0048565 name: digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] synonym: "gut development" BROAD [GOC:dph] synonym: "intestinal development" NARROW [] synonym: "intestine development" NARROW [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0055123 ! digestive system development [Term] id: GO:0048566 name: embryonic digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators] synonym: "embryonic digestive tract development" BROAD [GOC:dph] is_a: GO:0048565 ! digestive tract development is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0048567 name: ectodermal digestive tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm." [GOC:jid] synonym: "ectodermal gut morphogenesis" RELATED [GOC:dph] is_a: GO:0007439 ! ectodermal digestive tract development relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0048568 name: embryonic organ development namespace: biological_process def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] synonym: "embryonic organogenesis" EXACT [] is_a: GO:0048513 ! organ development relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0048569 name: post-embryonic organ development namespace: biological_process def: "Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] synonym: "post-embryonic organogenesis" EXACT [] is_a: GO:0048513 ! organ development [Term] id: GO:0048570 name: notochord morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis relationship: part_of GO:0030903 ! notochord development [Term] id: GO:0048571 name: long-day photoperiodism namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "response to long-day" EXACT [] synonym: "response to long-day photoperiod" RELATED [] synonym: "response to short-night" EXACT [] synonym: "short-night photoperiodism" EXACT [] is_a: GO:0009648 ! photoperiodism [Term] id: GO:0048572 name: short-day photoperiodism namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "long-night photoperiodism" EXACT [] synonym: "response to long-night" EXACT [] synonym: "response to short-day" EXACT [] synonym: "response to short-day photoperiod" RELATED [] is_a: GO:0009648 ! photoperiodism [Term] id: GO:0048573 name: photoperiodism, flowering namespace: biological_process def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "photoperiodic control of flowering time" EXACT [] synonym: "photoperiodic control of inflorescence development" EXACT [] synonym: "response to day length, flowering" EXACT [] synonym: "response to night length, flowering" EXACT [] synonym: "response to photoperiod, flowering" EXACT [] is_a: GO:0009648 ! photoperiodism relationship: part_of GO:0010228 ! vegetative to reproductive phase transition of meristem [Term] id: GO:0048574 name: long-day photoperiodism, flowering namespace: biological_process def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "long-day photoperiodic control of flowering" EXACT [] synonym: "long-day photoperiodic control of flowering time" EXACT [] synonym: "long-day photoperiodic control of inflorescence development" EXACT [] synonym: "response to long-day, flowering" EXACT [] synonym: "response to short-night, flowering" EXACT [] synonym: "short-night photoperiodism, flowering" EXACT [] is_a: GO:0048571 ! long-day photoperiodism is_a: GO:0048573 ! photoperiodism, flowering [Term] id: GO:0048575 name: short-day photoperiodism, flowering namespace: biological_process def: "A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "long-night photoperiodism, flowering" EXACT [] synonym: "response to long-night, flowering" EXACT [] synonym: "response to short-day, flowering" EXACT [] synonym: "short-day photoperiodic control of flowering" EXACT [] synonym: "short-day photoperiodic control of flowering time" EXACT [] synonym: "short-day photoperiodic control of inflorescence development" EXACT [] is_a: GO:0048572 ! short-day photoperiodism is_a: GO:0048573 ! photoperiodism, flowering [Term] id: GO:0048576 name: positive regulation of short-day photoperiodism, flowering namespace: biological_process def: "Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "activation of short-day photoperiodism, flowering" NARROW [] synonym: "stimulation of short-day photoperiodism, flowering" NARROW [] synonym: "up regulation of short-day photoperiodism, flowering" EXACT [] synonym: "up-regulation of short-day photoperiodism, flowering" EXACT [] synonym: "upregulation of short-day photoperiodism, flowering" EXACT [] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering relationship: positively_regulates GO:0048575 ! short-day photoperiodism, flowering [Term] id: GO:0048577 name: negative regulation of short-day photoperiodism, flowering namespace: biological_process def: "Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "down regulation of short-day photoperiodism, flowering" EXACT [] synonym: "down-regulation of short-day photoperiodism, flowering" EXACT [] synonym: "downregulation of short-day photoperiodism, flowering" EXACT [] synonym: "inhibition of short-day photoperiodism, flowering" NARROW [] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering relationship: negatively_regulates GO:0048575 ! short-day photoperiodism, flowering [Term] id: GO:0048578 name: positive regulation of long-day photoperiodism, flowering namespace: biological_process def: "Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "activation of long-day photoperiodism, flowering" NARROW [] synonym: "stimulation of long-day photoperiodism, flowering" NARROW [] synonym: "up regulation of long-day photoperiodism, flowering" EXACT [] synonym: "up-regulation of long-day photoperiodism, flowering" EXACT [] synonym: "upregulation of long-day photoperiodism, flowering" EXACT [] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering relationship: positively_regulates GO:0048574 ! long-day photoperiodism, flowering [Term] id: GO:0048579 name: negative regulation of long-day photoperiodism, flowering namespace: biological_process def: "Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "down regulation of long-day photoperiodism, flowering" EXACT [] synonym: "down-regulation of long-day photoperiodism, flowering" EXACT [] synonym: "downregulation of long-day photoperiodism, flowering" EXACT [] synonym: "inhibition of long-day photoperiodism, flowering" NARROW [] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering relationship: negatively_regulates GO:0048574 ! long-day photoperiodism, flowering [Term] id: GO:0048580 name: regulation of post-embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0009791 ! post-embryonic development [Term] id: GO:0048581 name: negative regulation of post-embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "down regulation of post-embryonic development" EXACT [] synonym: "down-regulation of post-embryonic development" EXACT [] synonym: "downregulation of post-embryonic development" EXACT [] synonym: "inhibition of post-embryonic development" NARROW [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0009791 ! post-embryonic development [Term] id: GO:0048582 name: positive regulation of post-embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "activation of post-embryonic development" NARROW [] synonym: "stimulation of post-embryonic development" NARROW [] synonym: "up regulation of post-embryonic development" EXACT [] synonym: "up-regulation of post-embryonic development" EXACT [] synonym: "upregulation of post-embryonic development" EXACT [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0009791 ! post-embryonic development [Term] id: GO:0048583 name: regulation of response to stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: gosubset_prok subset: high_level_annotation_qc is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0050896 ! response to stimulus [Term] id: GO:0048584 name: positive regulation of response to stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: high_level_annotation_qc synonym: "activation of response to stimulus" NARROW [] synonym: "stimulation of response to stimulus" NARROW [] synonym: "up regulation of response to stimulus" EXACT [] synonym: "up-regulation of response to stimulus" EXACT [] synonym: "upregulation of response to stimulus" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus relationship: positively_regulates GO:0050896 ! response to stimulus [Term] id: GO:0048585 name: negative regulation of response to stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: high_level_annotation_qc synonym: "down regulation of response to stimulus" EXACT [] synonym: "down-regulation of response to stimulus" EXACT [] synonym: "downregulation of response to stimulus" EXACT [] synonym: "inhibition of response to stimulus" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus relationship: negatively_regulates GO:0050896 ! response to stimulus [Term] id: GO:0048586 name: regulation of long-day photoperiodism, flowering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] is_a: GO:2000028 ! regulation of photoperiodism, flowering relationship: regulates GO:0048574 ! long-day photoperiodism, flowering [Term] id: GO:0048587 name: regulation of short-day photoperiodism, flowering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] is_a: GO:2000028 ! regulation of photoperiodism, flowering relationship: regulates GO:0048575 ! short-day photoperiodism, flowering [Term] id: GO:0048588 name: developmental cell growth namespace: biological_process def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete] synonym: "developmental growth of a unicellular organism" EXACT [] is_a: GO:0016049 ! cell growth is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048468 ! cell development [Term] id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] is_a: GO:0032502 ! developmental process is_a: GO:0040007 ! growth [Term] id: GO:0048592 name: eye morphogenesis namespace: biological_process alt_id: GO:0048748 def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0001654 ! eye development [Term] id: GO:0048593 name: camera-type eye morphogenesis namespace: biological_process alt_id: GO:0048594 alt_id: GO:0048595 def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu] synonym: "camera-style eye morphogenesis" EXACT [GOC:dph] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0048596 name: embryonic camera-type eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic eye morphogenesis" BROAD [] is_a: GO:0048048 ! embryonic eye morphogenesis relationship: part_of GO:0031076 ! embryonic camera-type eye development relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0048597 name: post-embryonic camera-type eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized during post-embryonic development." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] synonym: "post-embryonic camera-style eye morphogenesis" EXACT [] synonym: "post-embryonic eye morphogenesis" BROAD [] is_a: GO:0048050 ! post-embryonic eye morphogenesis relationship: part_of GO:0031077 ! post-embryonic camera-type eye development relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0048598 name: embryonic morphogenesis namespace: biological_process alt_id: GO:0048828 def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0048599 name: oocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] is_a: GO:0007281 ! germ cell development relationship: part_of GO:0009994 ! oocyte differentiation [Term] id: GO:0048600 name: oocyte fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0045165 ! cell fate commitment is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0009994 ! oocyte differentiation [Term] id: GO:0048601 name: oocyte morphogenesis namespace: biological_process def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] synonym: "oocyte morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0048602 name: fibroblast growth factor 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with fibroblast growth factor 1." [GOC:ebc] synonym: "FGF 1 binding" EXACT [] is_a: GO:0017134 ! fibroblast growth factor binding [Term] id: GO:0048603 name: fibroblast growth factor 2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with fibroblast growth factor 2." [GOC:ebc] synonym: "FGF 2 binding" EXACT [] is_a: GO:0017134 ! fibroblast growth factor binding [Term] id: GO:0048604 name: fibroblast growth factor 3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with fibroblast growth factor 3." [GOC:ebc] synonym: "FGF 3 binding" EXACT [] is_a: GO:0017134 ! fibroblast growth factor binding [Term] id: GO:0048605 name: fibroblast growth factor 4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with fibroblast growth factor 4." [GOC:ebc] synonym: "FGF 4 binding" EXACT [] is_a: GO:0017134 ! fibroblast growth factor binding [Term] id: GO:0048606 name: fibroblast growth factor 5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with fibroblast growth factor 5." [GOC:ebc] synonym: "FGF 5 binding" EXACT [] is_a: GO:0017134 ! fibroblast growth factor binding [Term] id: GO:0048607 name: fibroblast growth factor 6 binding namespace: molecular_function def: "Interacting selectively and non-covalently with fibroblast growth factor 6." [GOC:ebc] synonym: "FGF 6 binding" EXACT [] is_a: GO:0017134 ! fibroblast growth factor binding [Term] id: GO:0048608 name: reproductive structure development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0048609 name: multicellular organismal reproductive process namespace: biological_process def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb] synonym: "organismal reproductive process" BROAD [GOC:curators] synonym: "reproductive process in a multicellular organism" EXACT [GOC:curators] is_a: GO:0022414 ! reproductive process is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0048610 name: cellular process involved in reproduction namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism." [GOC:dph, GOC:jid] subset: gosubset_prok synonym: "reproductive cellular process" RELATED [GOC:dph, GOC:tb] is_a: GO:0009987 ! cellular process is_a: GO:0022414 ! reproductive process [Term] id: GO:0048611 name: embryonic ectodermal digestive tract development namespace: biological_process def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc] synonym: "embryonic ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048566 ! embryonic digestive tract development relationship: part_of GO:0007439 ! ectodermal digestive tract development [Term] id: GO:0048612 name: post-embryonic ectodermal digestive tract development namespace: biological_process def: "The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc] synonym: "post-embryonic ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0007439 ! ectodermal digestive tract development [Term] id: GO:0048613 name: embryonic ectodermal digestive tract morphogenesis namespace: biological_process def: "The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized." [GOC:jid, GOC:rc] synonym: "embryonic ectodermal gut morphogenesis" RELATED [GOC:dph] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048557 ! embryonic digestive tract morphogenesis relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis relationship: part_of GO:0048611 ! embryonic ectodermal digestive tract development [Term] id: GO:0048614 name: post-embryonic ectodermal digestive tract morphogenesis namespace: biological_process def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized." [GOC:jid, GOC:rc] synonym: "post-embryonic ectodermal gut morphogenesis" RELATED [GOC:dph] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis relationship: part_of GO:0048612 ! post-embryonic ectodermal digestive tract development relationship: part_of GO:0048621 ! post-embryonic digestive tract morphogenesis [Term] id: GO:0048615 name: embryonic anterior midgut (ectodermal) morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis relationship: part_of GO:0048613 ! embryonic ectodermal digestive tract morphogenesis [Term] id: GO:0048616 name: post-embryonic anterior midgut (ectodermal) morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis relationship: part_of GO:0048614 ! post-embryonic ectodermal digestive tract morphogenesis [Term] id: GO:0048617 name: embryonic foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007440 ! foregut morphogenesis [Term] id: GO:0048618 name: post-embryonic foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007440 ! foregut morphogenesis [Term] id: GO:0048619 name: embryonic hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007442 ! hindgut morphogenesis [Term] id: GO:0048620 name: post-embryonic hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007442 ! hindgut morphogenesis [Term] id: GO:0048621 name: post-embryonic digestive tract morphogenesis namespace: biological_process def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:jid, GOC:rc] synonym: "post-embryonic gut morphogenesis" BROAD [GOC:dph] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0048622 name: reproductive sporulation namespace: biological_process def: "OBSOLETE. The formation of reproductive spores." [GOC:jid] comment: This term was made obsolete because it was ambiguously defined and incorrectly placed in the ontology. is_obsolete: true [Term] id: GO:0048623 name: seed germination on parent plant namespace: biological_process def: "The process in which a seed germinates before being shed from the parent plant." [GOC:go_curators] synonym: "non-vegetative vivipary" BROAD [] synonym: "pre-harvest sprouting" EXACT [] synonym: "vivipary" BROAD [] is_a: GO:0009845 ! seed germination [Term] id: GO:0048624 name: plantlet formation on parent plant namespace: biological_process def: "The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed." [GOC:go_curators] synonym: "vegetative vivipary" BROAD [] synonym: "vivipary" BROAD [] is_a: GO:0019954 ! asexual reproduction is_a: GO:0032504 ! multicellular organism reproduction is_a: GO:0048507 ! meristem development [Term] id: GO:0048625 name: myoblast cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0045445 ! myoblast differentiation [Term] id: GO:0048626 name: myoblast cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a myoblast cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0048625 ! myoblast cell fate commitment [Term] id: GO:0048627 name: myoblast development namespace: biological_process def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048468 ! cell development relationship: part_of GO:0045445 ! myoblast differentiation [Term] id: GO:0048628 name: myoblast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048469 ! cell maturation relationship: part_of GO:0048627 ! myoblast development [Term] id: GO:0048629 name: trichome patterning namespace: biological_process def: "The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes." [GOC:jid, GOC:mtg_sensu, GOC:sm, GOC:tb, ISBN:0865427429, PMID:10368181] synonym: "trichome distribution" BROAD [] synonym: "trichome pattern biosynthesis" EXACT [] synonym: "trichome pattern formation" EXACT [] synonym: "trichome pattern specification" RELATED [] synonym: "trichome spacing" EXACT [] is_a: GO:0003002 ! regionalization is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: part_of GO:0010026 ! trichome differentiation [Term] id: GO:0048630 name: skeletal muscle tissue growth namespace: biological_process def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048631 name: regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0048641 ! regulation of skeletal muscle tissue development relationship: regulates GO:0048630 ! skeletal muscle tissue growth [Term] id: GO:0048632 name: negative regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "down regulation of skeletal muscle growth" EXACT [] synonym: "down-regulation of skeletal muscle growth" EXACT [] synonym: "downregulation of skeletal muscle growth" EXACT [] synonym: "inhibition of skeletal muscle growth" NARROW [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048640 ! negative regulation of developmental growth relationship: negatively_regulates GO:0048630 ! skeletal muscle tissue growth relationship: part_of GO:0048642 ! negative regulation of skeletal muscle tissue development [Term] id: GO:0048633 name: positive regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "activation of skeletal muscle growth" NARROW [] synonym: "stimulation of skeletal muscle growth" NARROW [] synonym: "up regulation of skeletal muscle growth" EXACT [] synonym: "up-regulation of skeletal muscle growth" EXACT [] synonym: "upregulation of skeletal muscle growth" EXACT [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048639 ! positive regulation of developmental growth relationship: part_of GO:0048643 ! positive regulation of skeletal muscle tissue development relationship: positively_regulates GO:0048630 ! skeletal muscle tissue growth [Term] id: GO:0048634 name: regulation of muscle organ development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0007517 ! muscle organ development [Term] id: GO:0048635 name: negative regulation of muscle organ development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators] synonym: "down regulation of muscle development" EXACT [] synonym: "down-regulation of muscle development" EXACT [] synonym: "downregulation of muscle development" EXACT [] synonym: "inhibition of muscle development" NARROW [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0007517 ! muscle organ development [Term] id: GO:0048636 name: positive regulation of muscle organ development namespace: biological_process def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators] synonym: "activation of muscle development" NARROW [] synonym: "stimulation of muscle development" NARROW [] synonym: "up regulation of muscle development" EXACT [] synonym: "up-regulation of muscle development" EXACT [] synonym: "upregulation of muscle development" EXACT [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0007517 ! muscle organ development [Term] id: GO:0048638 name: regulation of developmental growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0048589 ! developmental growth [Term] id: GO:0048639 name: positive regulation of developmental growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] synonym: "activation of developmental growth" NARROW [] synonym: "stimulation of developmental growth" NARROW [] synonym: "up regulation of developmental growth" EXACT [] synonym: "up-regulation of developmental growth" EXACT [] synonym: "upregulation of developmental growth" EXACT [] is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0048589 ! developmental growth [Term] id: GO:0048640 name: negative regulation of developmental growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] synonym: "down regulation of developmental growth" EXACT [] synonym: "down-regulation of developmental growth" EXACT [] synonym: "downregulation of developmental growth" EXACT [] synonym: "inhibition of developmental growth" NARROW [] is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0048589 ! developmental growth [Term] id: GO:0048641 name: regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] is_a: GO:0016202 ! regulation of striated muscle tissue development relationship: regulates GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048642 name: negative regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] synonym: "down regulation of skeletal muscle development" EXACT [] synonym: "down-regulation of skeletal muscle development" EXACT [] synonym: "downregulation of skeletal muscle development" EXACT [] synonym: "inhibition of skeletal muscle development" NARROW [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development relationship: negatively_regulates GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048643 name: positive regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators] synonym: "activation of skeletal muscle development" NARROW [] synonym: "stimulation of skeletal muscle development" NARROW [] synonym: "up regulation of skeletal muscle development" EXACT [] synonym: "up-regulation of skeletal muscle development" EXACT [] synonym: "upregulation of skeletal muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development relationship: positively_regulates GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048644 name: muscle organ morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0007517 ! muscle organ development [Term] id: GO:0048645 name: organ formation namespace: biological_process def: "The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid] synonym: "initiation of an organ primordium" NARROW [] synonym: "organ primordium initiation" NARROW [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0009887 ! organ morphogenesis [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_generic synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048647 name: polyphenic determination namespace: biological_process def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues." [GOC:jid] is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0048648 name: caste determination namespace: biological_process def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid] is_a: GO:0048647 ! polyphenic determination [Term] id: GO:0048649 name: caste determination, influence by genetic factors namespace: biological_process def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid] is_a: GO:0048648 ! caste determination is_a: GO:0048652 ! polyphenic determination, influence by genetic factors [Term] id: GO:0048650 name: caste determination, influence by environmental factors namespace: biological_process def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid] is_a: GO:0048648 ! caste determination is_a: GO:0048651 ! polyphenic determination, influence by environmental factors [Term] id: GO:0048651 name: polyphenic determination, influence by environmental factors namespace: biological_process def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues." [GOC:jid] is_a: GO:0009605 ! response to external stimulus is_a: GO:0048647 ! polyphenic determination [Term] id: GO:0048652 name: polyphenic determination, influence by genetic factors namespace: biological_process def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues." [GOC:jid] is_a: GO:0048647 ! polyphenic determination [Term] id: GO:0048653 name: anther development namespace: biological_process def: "The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure." [GOC:jid, GOC:sm] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048443 ! stamen development [Term] id: GO:0048654 name: anther morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anther are generated and organized." [GOC:jid, GOC:sm] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048448 ! stamen morphogenesis relationship: part_of GO:0048653 ! anther development [Term] id: GO:0048655 name: tapetal layer morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tapetal layer are generated and organized. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm] synonym: "differentiation of tapetal layer" NARROW [] synonym: "tapetum morphogenesis" EXACT [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0048654 ! anther morphogenesis relationship: part_of GO:0048658 ! tapetal layer development [Term] id: GO:0048656 name: tapetal layer formation namespace: biological_process def: "The process that gives rise to the tapetal layer. This process pertains to the initial formation of a structure from unspecified parts. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm] synonym: "tapetum formation" EXACT [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048455 ! stamen formation relationship: part_of GO:0048655 ! tapetal layer morphogenesis [Term] id: GO:0048657 name: tapetal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a tapetal cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048656 ! tapetal layer formation [Term] id: GO:0048658 name: tapetal layer development namespace: biological_process def: "The process whose specific outcome is the progression of the tapetal layer over time, from its formation to the mature structure." [GOC:jid, GOC:sm] synonym: "tapetum development" EXACT [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048653 ! anther development [Term] id: GO:0048659 name: smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698] synonym: "SMC proliferation" EXACT [] is_a: GO:0033002 ! muscle cell proliferation [Term] id: GO:0048660 name: regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "regulation of SMC proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0048659 ! smooth muscle cell proliferation [Term] id: GO:0048661 name: positive regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "activation of smooth muscle cell proliferation" NARROW [] synonym: "positive regulation of SMC proliferation" EXACT [] synonym: "stimulation of smooth muscle cell proliferation" NARROW [] synonym: "up regulation of smooth muscle cell proliferation" EXACT [] synonym: "up-regulation of smooth muscle cell proliferation" EXACT [] synonym: "upregulation of smooth muscle cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation relationship: positively_regulates GO:0048659 ! smooth muscle cell proliferation [Term] id: GO:0048662 name: negative regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "down regulation of smooth muscle cell proliferation" EXACT [] synonym: "down-regulation of smooth muscle cell proliferation" EXACT [] synonym: "downregulation of smooth muscle cell proliferation" EXACT [] synonym: "inhibition of smooth muscle cell proliferation" NARROW [] synonym: "negative regulation of SMC proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation relationship: negatively_regulates GO:0048659 ! smooth muscle cell proliferation [Term] id: GO:0048663 name: neuron fate commitment namespace: biological_process alt_id: GO:0042055 def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph] synonym: "neuron lineage restriction" EXACT [] synonym: "neuronal lineage restriction" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030182 ! neuron differentiation [Term] id: GO:0048664 name: neuron fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dph] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0048663 ! neuron fate commitment [Term] id: GO:0048665 name: neuron fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0048663 ! neuron fate commitment [Term] id: GO:0048666 name: neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030182 ! neuron differentiation [Term] id: GO:0048667 name: cell morphogenesis involved in neuron differentiation namespace: biological_process def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0048668 name: collateral sprouting namespace: biological_process def: "The process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0048669 name: collateral sprouting in absence of injury namespace: biological_process def: "The process in which outgrowths develop from the axons of intact undamaged neurons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048668 ! collateral sprouting [Term] id: GO:0048670 name: regulation of collateral sprouting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0050770 ! regulation of axonogenesis relationship: regulates GO:0048668 ! collateral sprouting [Term] id: GO:0048671 name: negative regulation of collateral sprouting namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of collateral sprouting" EXACT [] synonym: "down-regulation of collateral sprouting" EXACT [] synonym: "downregulation of collateral sprouting" EXACT [] synonym: "inhibition of collateral sprouting" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0048670 ! regulation of collateral sprouting is_a: GO:0050771 ! negative regulation of axonogenesis relationship: negatively_regulates GO:0048668 ! collateral sprouting [Term] id: GO:0048672 name: positive regulation of collateral sprouting namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of collateral sprouting" NARROW [] synonym: "stimulation of collateral sprouting" NARROW [] synonym: "up regulation of collateral sprouting" EXACT [] synonym: "up-regulation of collateral sprouting" EXACT [] synonym: "upregulation of collateral sprouting" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048670 ! regulation of collateral sprouting is_a: GO:0050772 ! positive regulation of axonogenesis relationship: positively_regulates GO:0048668 ! collateral sprouting [Term] id: GO:0048673 name: collateral sprouting of intact axon in response to injury namespace: biological_process def: "The process in which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input." [GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0031103 ! axon regeneration is_a: GO:0048668 ! collateral sprouting [Term] id: GO:0048674 name: collateral sprouting of injured axon namespace: biological_process def: "The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048668 ! collateral sprouting is_a: GO:0048682 ! sprouting of injured axon [Term] id: GO:0048675 name: axon extension namespace: biological_process def: "Long distance growth of a single process." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0048676 name: axon extension involved in development namespace: biological_process def: "Long distance growth of a single axon process involved in cellular development." [GOC:jid] is_a: GO:0048675 ! axon extension [Term] id: GO:0048677 name: axon extension involved in regeneration namespace: biological_process def: "Long distance growth of a single axon process involved in regeneration of the neuron." [GOC:jid] is_a: GO:0048676 ! axon extension involved in development is_a: GO:0048682 ! sprouting of injured axon [Term] id: GO:0048678 name: response to axon injury namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0009611 ! response to wounding [Term] id: GO:0048679 name: regulation of axon regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050770 ! regulation of axonogenesis is_a: GO:0070570 ! regulation of neuron projection regeneration relationship: regulates GO:0031103 ! axon regeneration [Term] id: GO:0048680 name: positive regulation of axon regeneration namespace: biological_process def: "Any process that activates, maintains or increases the rate of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of axon regeneration" NARROW [] synonym: "stimulation of axon regeneration" NARROW [] synonym: "up regulation of axon regeneration" EXACT [] synonym: "up-regulation of axon regeneration" EXACT [] synonym: "upregulation of axon regeneration" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0048679 ! regulation of axon regeneration is_a: GO:0050772 ! positive regulation of axonogenesis is_a: GO:0070572 ! positive regulation of neuron projection regeneration relationship: positively_regulates GO:0031103 ! axon regeneration [Term] id: GO:0048681 name: negative regulation of axon regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of axon regeneration" EXACT [] synonym: "down-regulation of axon regeneration" EXACT [] synonym: "downregulation of axon regeneration" EXACT [] synonym: "inhibition of axon regeneration" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0048679 ! regulation of axon regeneration is_a: GO:0050771 ! negative regulation of axonogenesis is_a: GO:0070571 ! negative regulation of neuron projection regeneration relationship: negatively_regulates GO:0031103 ! axon regeneration [Term] id: GO:0048682 name: sprouting of injured axon namespace: biological_process def: "The process involved in sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0031103 ! axon regeneration [Term] id: GO:0048683 name: regulation of collateral sprouting of intact axon in response to injury namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048670 ! regulation of collateral sprouting is_a: GO:0048679 ! regulation of axon regeneration relationship: regulates GO:0048673 ! collateral sprouting of intact axon in response to injury [Term] id: GO:0048684 name: positive regulation of collateral sprouting of intact axon in response to injury namespace: biological_process def: "Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of collateral sprouting of intact axon in response to injury" NARROW [] synonym: "stimulation of collateral sprouting of intact axon in response to injury" NARROW [] synonym: "up regulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "up-regulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "upregulation of collateral sprouting of intact axon in response to injury" EXACT [] is_a: GO:0048672 ! positive regulation of collateral sprouting is_a: GO:0048680 ! positive regulation of axon regeneration is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury relationship: positively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury [Term] id: GO:0048685 name: negative regulation of collateral sprouting of intact axon in response to injury namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "down-regulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "downregulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "inhibition of collateral sprouting of intact axon in response to injury" NARROW [] is_a: GO:0048671 ! negative regulation of collateral sprouting is_a: GO:0048681 ! negative regulation of axon regeneration is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury relationship: negatively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury [Term] id: GO:0048686 name: regulation of sprouting of injured axon namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0048679 ! regulation of axon regeneration relationship: regulates GO:0048682 ! sprouting of injured axon [Term] id: GO:0048687 name: positive regulation of sprouting of injured axon namespace: biological_process def: "Any process that activates, maintains or increases the rate of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of sprouting of injured axon" NARROW [] synonym: "stimulation of sprouting of injured axon" NARROW [] synonym: "up regulation of sprouting of injured axon" EXACT [] synonym: "up-regulation of sprouting of injured axon" EXACT [] synonym: "upregulation of sprouting of injured axon" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048680 ! positive regulation of axon regeneration is_a: GO:0048686 ! regulation of sprouting of injured axon relationship: positively_regulates GO:0048682 ! sprouting of injured axon [Term] id: GO:0048688 name: negative regulation of sprouting of injured axon namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of sprouting of injured axon" EXACT [] synonym: "down-regulation of sprouting of injured axon" EXACT [] synonym: "downregulation of sprouting of injured axon" EXACT [] synonym: "inhibition of sprouting of injured axon" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0048681 ! negative regulation of axon regeneration is_a: GO:0048686 ! regulation of sprouting of injured axon relationship: negatively_regulates GO:0048682 ! sprouting of injured axon [Term] id: GO:0048689 name: formation of growth cone in injured axon namespace: biological_process def: "The formation of a growth cone in an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048682 ! sprouting of injured axon [Term] id: GO:0048690 name: regulation of axon extension involved in regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048686 ! regulation of sprouting of injured axon relationship: regulates GO:0048677 ! axon extension involved in regeneration [Term] id: GO:0048691 name: positive regulation of axon extension involved in regeneration namespace: biological_process def: "Any process that activates, maintains or increases the rate of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of axon extension involved in regeneration" NARROW [] synonym: "stimulation of axon extension involved in regeneration" NARROW [] synonym: "up regulation of axon extension involved in regeneration" EXACT [] synonym: "up-regulation of axon extension involved in regeneration" EXACT [] synonym: "upregulation of axon extension involved in regeneration" EXACT [] is_a: GO:0045773 ! positive regulation of axon extension is_a: GO:0048687 ! positive regulation of sprouting of injured axon is_a: GO:0048690 ! regulation of axon extension involved in regeneration relationship: positively_regulates GO:0048677 ! axon extension involved in regeneration [Term] id: GO:0048692 name: negative regulation of axon extension involved in regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of axon extension involved in regeneration" EXACT [] synonym: "down-regulation of axon extension involved in regeneration" EXACT [] synonym: "downregulation of axon extension involved in regeneration" EXACT [] synonym: "inhibition of axon extension involved in regeneration" NARROW [] is_a: GO:0030517 ! negative regulation of axon extension is_a: GO:0048688 ! negative regulation of sprouting of injured axon is_a: GO:0048690 ! regulation of axon extension involved in regeneration relationship: negatively_regulates GO:0048677 ! axon extension involved in regeneration [Term] id: GO:0048693 name: regulation of collateral sprouting of injured axon namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048670 ! regulation of collateral sprouting is_a: GO:0048686 ! regulation of sprouting of injured axon relationship: regulates GO:0048674 ! collateral sprouting of injured axon [Term] id: GO:0048694 name: positive regulation of collateral sprouting of injured axon namespace: biological_process def: "Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of collateral sprouting of injured axon" NARROW [] synonym: "stimulation of collateral sprouting of injured axon" NARROW [] synonym: "up regulation of collateral sprouting of injured axon" EXACT [] synonym: "up-regulation of collateral sprouting of injured axon" EXACT [] synonym: "upregulation of collateral sprouting of injured axon" EXACT [] is_a: GO:0048672 ! positive regulation of collateral sprouting is_a: GO:0048687 ! positive regulation of sprouting of injured axon is_a: GO:0048693 ! regulation of collateral sprouting of injured axon relationship: positively_regulates GO:0048674 ! collateral sprouting of injured axon [Term] id: GO:0048695 name: negative regulation of collateral sprouting of injured axon namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of collateral sprouting of injured axon" EXACT [] synonym: "down-regulation of collateral sprouting of injured axon" EXACT [] synonym: "downregulation of collateral sprouting of injured axon" EXACT [] synonym: "inhibition of collateral sprouting of injured axon" NARROW [] is_a: GO:0048671 ! negative regulation of collateral sprouting is_a: GO:0048688 ! negative regulation of sprouting of injured axon is_a: GO:0048693 ! regulation of collateral sprouting of injured axon relationship: negatively_regulates GO:0048674 ! collateral sprouting of injured axon [Term] id: GO:0048696 name: regulation of collateral sprouting in absence of injury namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048670 ! regulation of collateral sprouting relationship: regulates GO:0048669 ! collateral sprouting in absence of injury [Term] id: GO:0048697 name: positive regulation of collateral sprouting in absence of injury namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of collateral sprouting in the absence of injury" NARROW [] synonym: "stimulation of collateral sprouting in the absence of injury" NARROW [] synonym: "up regulation of collateral sprouting in the absence of injury" EXACT [] synonym: "up-regulation of collateral sprouting in the absence of injury" EXACT [] synonym: "upregulation of collateral sprouting in the absence of injury" EXACT [] is_a: GO:0048672 ! positive regulation of collateral sprouting is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury relationship: positively_regulates GO:0048669 ! collateral sprouting in absence of injury [Term] id: GO:0048698 name: negative regulation of collateral sprouting in absence of injury namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of collateral sprouting in the absence of injury" EXACT [] synonym: "down-regulation of collateral sprouting in the absence of injury" EXACT [] synonym: "downregulation of collateral sprouting in the absence of injury" EXACT [] synonym: "inhibition of collateral sprouting in the absence of injury" NARROW [] is_a: GO:0048671 ! negative regulation of collateral sprouting is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury relationship: negatively_regulates GO:0048669 ! collateral sprouting in absence of injury [Term] id: GO:0048699 name: generation of neurons namespace: biological_process def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] synonym: "generation of neurons" EXACT [GOC:curators] is_a: GO:0022008 ! neurogenesis [Term] id: GO:0048700 name: acquisition of desiccation tolerance namespace: biological_process def: "The process in which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state." [GOC:jid, GOC:ki] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022611 ! dormancy process relationship: part_of GO:0010162 ! seed dormancy [Term] id: GO:0048701 name: embryonic cranial skeleton morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase." [GOC:dsf, GOC:jid, PMID:16049113] synonym: "embryonic cranium morphogenesis" EXACT [] is_a: GO:0048704 ! embryonic skeletal system morphogenesis [Term] id: GO:0048702 name: embryonic neurocranium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain." [GOC:dsf, GOC:jid, PMID:16049113] synonym: "embryonic braincase morphogenesis" EXACT [] synonym: "embryonic chondrocranium morphogenesis" EXACT [GOC:dph] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis [Term] id: GO:0048703 name: embryonic viscerocranium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones." [GOC:dsf, GOC:jid, PMID:16049113] synonym: "embryonic pharyngeal skeleton morphogenesis" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis [Term] id: GO:0048704 name: embryonic skeletal system morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113] synonym: "embryonic skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0048706 ! embryonic skeletal system development [Term] id: GO:0048705 name: skeletal system morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb] synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0001501 ! skeletal system development [Term] id: GO:0048706 name: embryonic skeletal system development namespace: biological_process def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113] synonym: "embryonic skeletal development" EXACT [GOC:dph, GOC:tb] is_a: GO:0001501 ! skeletal system development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0048707 name: instar larval or pupal morphogenesis namespace: biological_process def: "The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized." [GOC:mtg_sensu, GOC:rc] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0002165 ! instar larval or pupal development [Term] id: GO:0048708 name: astrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0048709 name: oligodendrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0048710 name: regulation of astrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation relationship: regulates GO:0048708 ! astrocyte differentiation [Term] id: GO:0048711 name: positive regulation of astrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "activation of astrocyte differentiation" NARROW [] synonym: "stimulation of astrocyte differentiation" NARROW [] synonym: "up regulation of astrocyte differentiation" EXACT [] synonym: "up-regulation of astrocyte differentiation" EXACT [] synonym: "upregulation of astrocyte differentiation" EXACT [] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation relationship: positively_regulates GO:0048708 ! astrocyte differentiation [Term] id: GO:0048712 name: negative regulation of astrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "down regulation of astrocyte differentiation" EXACT [] synonym: "down-regulation of astrocyte differentiation" EXACT [] synonym: "downregulation of astrocyte differentiation" EXACT [] synonym: "inhibition of astrocyte differentiation" NARROW [] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation relationship: negatively_regulates GO:0048708 ! astrocyte differentiation [Term] id: GO:0048713 name: regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation relationship: regulates GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0048714 name: positive regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "activation of oligodendrocyte differentiation" NARROW [] synonym: "stimulation of oligodendrocyte differentiation" NARROW [] synonym: "up regulation of oligodendrocyte differentiation" EXACT [] synonym: "up-regulation of oligodendrocyte differentiation" EXACT [] synonym: "upregulation of oligodendrocyte differentiation" EXACT [] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation relationship: positively_regulates GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0048715 name: negative regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "down regulation of oligodendrocyte differentiation" EXACT [] synonym: "down-regulation of oligodendrocyte differentiation" EXACT [] synonym: "downregulation of oligodendrocyte differentiation" EXACT [] synonym: "inhibition of oligodendrocyte differentiation" NARROW [] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation relationship: negatively_regulates GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0048716 name: labrum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of labrum are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048726 ! labrum development [Term] id: GO:0048717 name: anterior cibarial plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anterior cibarial plate are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048722 ! anterior cibarial plate development [Term] id: GO:0048718 name: fish trap bristle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a fish trap bristle are generated and organized." [GOC:rc] is_a: GO:0008407 ! bristle morphogenesis is_a: GO:0048563 ! post-embryonic organ morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048725 ! fish trap bristle development [Term] id: GO:0048719 name: epistomal sclerite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the epistomal sclerite are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048724 ! epistomal sclerite development [Term] id: GO:0048720 name: posterior cibarial plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the posterior cibarial plate are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048727 ! posterior cibarial plate development [Term] id: GO:0048721 name: clypeus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the clypeus are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048723 ! clypeus development [Term] id: GO:0048722 name: anterior cibarial plate development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048723 name: clypeus development namespace: biological_process def: "The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048724 name: epistomal sclerite development namespace: biological_process def: "The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048725 name: fish trap bristle development namespace: biological_process def: "The process whose specific outcome is the progression of the fish trap bristle over time, from its formation to the mature structure." [GOC:rc] is_a: GO:0022416 ! bristle development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048726 name: labrum development namespace: biological_process def: "The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048727 name: posterior cibarial plate development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048728 name: proboscis development namespace: biological_process alt_id: GO:0016349 def: "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc] is_a: GO:0048513 ! organ development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048729 name: tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009888 ! tissue development [Term] id: GO:0048730 name: epidermis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003] synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0008544 ! epidermis development relationship: part_of GO:0009887 ! organ morphogenesis [Term] id: GO:0048731 name: system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0048732 name: gland development namespace: biological_process def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] is_a: GO:0048513 ! organ development [Term] id: GO:0048733 name: sebaceous gland development namespace: biological_process def: "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048732 ! gland development [Term] id: GO:0048734 name: proboscis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jid, GOC:rc] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0048728 ! proboscis development [Term] id: GO:0048735 name: haltere morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a haltere are generated and organized." [GOC:jid, GOC:rc] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis relationship: part_of GO:0007481 ! haltere disc morphogenesis relationship: part_of GO:0007482 ! haltere development [Term] id: GO:0048736 name: appendage development namespace: biological_process def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0048737 name: imaginal disc-derived appendage development namespace: biological_process def: "The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:jid, GOC:mtg_sensu, GOC:rc] is_a: GO:0048736 ! appendage development [Term] id: GO:0048738 name: cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] synonym: "heart muscle development" EXACT [] is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0048739 name: cardiac muscle fiber development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] synonym: "cardiac muscle fibre development" EXACT [] synonym: "heart muscle fiber development" RELATED [] is_a: GO:0048747 ! muscle fiber development relationship: part_of GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0048740 name: striated muscle fiber development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] comment: This term was made obsolete because it was an unnecessary grouping term. Striated muscle comprises skeletal and cardiac muscle, but GO has opted not to group the muscle fiber development terms. synonym: "myogenesis" EXACT [] synonym: "striated muscle fibre development" EXACT [] is_obsolete: true [Term] id: GO:0048741 name: skeletal muscle fiber development namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "skeletal muscle fibre development" EXACT [] synonym: "skeletal myofiber development" EXACT [] synonym: "skeletal myofibre development" EXACT [] is_a: GO:0048747 ! muscle fiber development relationship: part_of GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048742 name: regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm] synonym: "regulation of skeletal muscle fibre development" EXACT [] synonym: "regulation of skeletal myofiber development" EXACT [] synonym: "regulation of skeletal myofibre development" EXACT [] is_a: GO:0048641 ! regulation of skeletal muscle tissue development is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0048741 ! skeletal muscle fiber development [Term] id: GO:0048743 name: positive regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "activation of skeletal muscle fiber development" NARROW [] synonym: "positive regulation of skeletal muscle fibre development" EXACT [] synonym: "positive regulation of skeletal myofiber development" EXACT [] synonym: "positive regulation of skeletal myofibre development" EXACT [] synonym: "stimulation of skeletal muscle fiber development" NARROW [] synonym: "up regulation of skeletal muscle fiber development" EXACT [] synonym: "up-regulation of skeletal muscle fiber development" EXACT [] synonym: "upregulation of skeletal muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation relationship: positively_regulates GO:0048741 ! skeletal muscle fiber development [Term] id: GO:0048744 name: negative regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "down regulation of skeletal muscle fiber development" EXACT [] synonym: "down-regulation of skeletal muscle fiber development" EXACT [] synonym: "downregulation of skeletal muscle fiber development" EXACT [] synonym: "inhibition of skeletal muscle fiber development" NARROW [] synonym: "negative regulation of skeletal muscle fibre development" EXACT [] synonym: "negative regulation of skeletal myofiber development" EXACT [] synonym: "negative regulation of skeletal myofibre development" EXACT [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation relationship: negatively_regulates GO:0048741 ! skeletal muscle fiber development relationship: part_of GO:0048642 ! negative regulation of skeletal muscle tissue development [Term] id: GO:0048745 name: smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] is_a: GO:0060537 ! muscle tissue development [Term] id: GO:0048746 name: smooth muscle fiber development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] comment: This term was made obsolete because smooth muscle does not have fibers. synonym: "smooth muscle fibre development" EXACT [] is_obsolete: true [Term] id: GO:0048747 name: muscle fiber development namespace: biological_process def: "The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "muscle fibre development" EXACT [] synonym: "myofiber development" EXACT [] synonym: "myofibre development" EXACT [] is_a: GO:0055002 ! striated muscle cell development [Term] id: GO:0048749 name: compound eye development namespace: biological_process alt_id: GO:0007456 def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, http://en.wikipedia.org/wiki/Eye] synonym: "insect-type retina development" EXACT [PMID:11735386] is_a: GO:0001654 ! eye development [Term] id: GO:0048750 name: compound eye corneal lens morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the compound eye corneal lens are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0001745 ! compound eye morphogenesis relationship: part_of GO:0048058 ! compound eye corneal lens development [Term] id: GO:0048752 name: semicircular canal morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the semicircular canals are generated and organized." [GOC:dgh, GOC:dph, GOC:jid] synonym: "embryonic semicircular canal morphogenesis" EXACT [] is_a: GO:0035239 ! tube morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0060872 ! semicircular canal development [Term] id: GO:0048753 name: pigment granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc] subset: goslim_pir synonym: "pigment granule organisation" EXACT [GOC:curators] synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0033059 ! cellular pigmentation [Term] id: GO:0048754 name: branching morphogenesis of a tube namespace: biological_process def: "The process in which the anatomical structures of branches in a tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0001763 ! morphogenesis of a branching structure is_a: GO:0035239 ! tube morphogenesis [Term] id: GO:0048755 name: branching morphogenesis of a nerve namespace: biological_process def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0001763 ! morphogenesis of a branching structure relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0048756 name: sieve cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials." [CL:0000294, GOC:jid] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0010088 ! phloem development [Term] id: GO:0048757 name: pigment granule maturation namespace: biological_process def: "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:dgh, GOC:jid, GOC:mh] is_a: GO:0021700 ! developmental maturation is_a: GO:0043482 ! cellular pigment accumulation relationship: part_of GO:0050931 ! pigment cell differentiation [Term] id: GO:0048758 name: companion cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [CL:0000284, GOC:jid] is_a: GO:0048760 ! parenchymal cell differentiation relationship: part_of GO:0010088 ! phloem development [Term] id: GO:0048759 name: vessel member cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened." [GOC:jid, PO:0002003] synonym: "vessel element cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0010089 ! xylem development [Term] id: GO:0048760 name: parenchymal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure." [CL:0000668, GOC:jid, ISBN:069716957X, PO:0005421] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048761 name: collenchyma cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles." [CL:0000330, GOC:jid, PO:0000075] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048762 name: mesenchymal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060485 ! mesenchyme development [Term] id: GO:0048763 name: calcium-induced calcium release activity namespace: molecular_function def: "Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration." [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752] is_a: GO:0005218 ! intracellular ligand-gated calcium channel activity [Term] id: GO:0048764 name: trichoblast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state." [GOC:jid] is_a: GO:0048469 ! cell maturation relationship: part_of GO:0010054 ! trichoblast differentiation [Term] id: GO:0048765 name: root hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a root hair cell." [GOC:jid] is_a: GO:0048764 ! trichoblast maturation [Term] id: GO:0048766 name: root hair initiation namespace: biological_process def: "The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth." [GOC:jid, PMID:12468740] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0048765 ! root hair cell differentiation [Term] id: GO:0048767 name: root hair elongation namespace: biological_process def: "The process in which the root hair grows longer." [GOC:jid, PMID:12468740] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0048765 ! root hair cell differentiation [Term] id: GO:0048768 name: root hair cell tip growth namespace: biological_process def: "Localized growth of a plant root hair tip by extension of the cell wall." [GOC:jid, GOC:ki, PMID:12468740] synonym: "root hair tip growth" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0009932 ! cell tip growth relationship: part_of GO:0048767 ! root hair elongation [Term] id: GO:0048769 name: sarcomerogenesis namespace: biological_process def: "The process in which sarcomeres are added in series within a fiber." [GOC:jid, GOC:lm, PMID:15947030] synonym: "myofibril production" EXACT systematic_synonym [] is_a: GO:0031032 ! actomyosin structure organization relationship: part_of GO:0030239 ! myofibril assembly [Term] id: GO:0048770 name: pigment granule namespace: cellular_component def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0048771 name: tissue remodeling namespace: biological_process def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc] subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0048772 name: leucophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance." [GOC:jid, GOC:mh] synonym: "leucophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0048773 name: erythrophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance." [GOC:jid, GOC:mh] synonym: "erythrophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0048774 name: cyanophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes." [GOC:jid, GOC:mh] synonym: "cyanophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0048775 name: regulation of leucophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leucophore differentiation." [GOC:mh] is_a: GO:0050932 ! regulation of pigment cell differentiation relationship: regulates GO:0048772 ! leucophore differentiation [Term] id: GO:0048776 name: negative regulation of leucophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation." [GOC:mh] synonym: "down regulation of leucophore differentiation" EXACT [] synonym: "down-regulation of leucophore differentiation" EXACT [] synonym: "downregulation of leucophore differentiation" EXACT [] synonym: "inhibition of leucophore differentiation" NARROW [] is_a: GO:0048775 ! regulation of leucophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation relationship: negatively_regulates GO:0048772 ! leucophore differentiation [Term] id: GO:0048777 name: positive regulation of leucophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leucophore differentiation." [GOC:mh] synonym: "activation of leucophore differentiation" NARROW [] synonym: "stimulation of leucophore differentiation" NARROW [] synonym: "up regulation of leucophore differentiation" EXACT [] synonym: "up-regulation of leucophore differentiation" EXACT [] synonym: "upregulation of leucophore differentiation" EXACT [] is_a: GO:0048775 ! regulation of leucophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation relationship: positively_regulates GO:0048772 ! leucophore differentiation [Term] id: GO:0048778 name: regulation of erythrophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrophore differentiation." [GOC:mh] is_a: GO:0050932 ! regulation of pigment cell differentiation relationship: regulates GO:0048773 ! erythrophore differentiation [Term] id: GO:0048779 name: negative regulation of erythrophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrophore differentiation." [GOC:mh] synonym: "down regulation of erythrophore differentiation" EXACT [] synonym: "down-regulation of erythrophore differentiation" EXACT [] synonym: "downregulation of erythrophore differentiation" EXACT [] synonym: "inhibition of erythrophore differentiation" NARROW [] is_a: GO:0048778 ! regulation of erythrophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation relationship: negatively_regulates GO:0048773 ! erythrophore differentiation [Term] id: GO:0048780 name: positive regulation of erythrophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation." [GOC:mh] synonym: "activation of erythrophore differentiation" NARROW [] synonym: "stimulation of erythrophore differentiation" NARROW [] synonym: "up regulation of erythrophore differentiation" EXACT [] synonym: "up-regulation of erythrophore differentiation" EXACT [] synonym: "upregulation of erythrophore differentiation" EXACT [] is_a: GO:0048778 ! regulation of erythrophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation relationship: positively_regulates GO:0048773 ! erythrophore differentiation [Term] id: GO:0048781 name: regulation of cyanophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyanophore differentiation." [GOC:mh] is_a: GO:0050932 ! regulation of pigment cell differentiation relationship: regulates GO:0048774 ! cyanophore differentiation [Term] id: GO:0048782 name: negative regulation of cyanophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyanophore differentiation." [GOC:mh] synonym: "down regulation of cyanophore differentiation" EXACT [] synonym: "down-regulation of cyanophore differentiation" EXACT [] synonym: "downregulation of cyanophore differentiation" EXACT [] synonym: "inhibition of cyanophore differentiation" NARROW [] is_a: GO:0048781 ! regulation of cyanophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation relationship: negatively_regulates GO:0048774 ! cyanophore differentiation [Term] id: GO:0048783 name: positive regulation of cyanophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation." [GOC:mh] synonym: "activation of cyanophore differentiation" NARROW [] synonym: "stimulation of cyanophore differentiation" NARROW [] synonym: "up regulation of cyanophore differentiation" EXACT [] synonym: "up-regulation of cyanophore differentiation" EXACT [] synonym: "upregulation of cyanophore differentiation" EXACT [] is_a: GO:0048781 ! regulation of cyanophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation relationship: positively_regulates GO:0048774 ! cyanophore differentiation [Term] id: GO:0048784 name: pigment biosynthetic process involved in pigment granule maturation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pigment, contributing to the process in which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:jid] synonym: "pigment biosynthetic process during pigment granule maturation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation relationship: part_of GO:0048757 ! pigment granule maturation [Term] id: GO:0048785 name: hatching gland development namespace: biological_process def: "The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process." [GOC:bf, GOC:dh, GOC:jid] is_a: GO:0048732 ! gland development [Term] id: GO:0048786 name: presynaptic active zone namespace: cellular_component def: "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, PMID:3152289] synonym: "pre-synaptic active zone" EXACT [] xref: NIF_Subcellular:sao792027222 is_a: GO:0044456 ! synapse part [Term] id: GO:0048787 name: presynaptic active zone membrane namespace: cellular_component def: "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289] synonym: "active zone plasma membrane" EXACT [] synonym: "active zone pre-synaptic plasma membrane" EXACT [] synonym: "active zone presynaptic plasma membrane" EXACT [] synonym: "pre-synaptic active zone membrane" EXACT [] is_a: GO:0042734 ! presynaptic membrane relationship: part_of GO:0048786 ! presynaptic active zone [Term] id: GO:0048788 name: presynaptic cytoskeletal matrix assembled at active zones namespace: cellular_component def: "The specialized cytoskeletal matrix assembled at the active zones of the presynaptic nerve terminal. The cytoskeletal matrix is a proteinaceous structure involved in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. The cytomatrix protein exclusively assembled at active zones, is thought to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, PMID:10944438] synonym: "CAZ" NARROW [] synonym: "pre-synaptic cytoskeletal matrix assembled at active zones" RELATED [] synonym: "presynaptic cytomatrix assembled at active zones" EXACT [] synonym: "presynaptic dense body" NARROW [PMID:16709774] synonym: "synaptic ribbon" NARROW [PMID:19264728] synonym: "T-bar" NARROW [PMID:20127822] synonym: "T-bar ribbon" NARROW [PMID:16384719] is_a: GO:0030863 ! cortical cytoskeleton is_a: GO:0044456 ! synapse part relationship: part_of GO:0048786 ! presynaptic active zone [Term] id: GO:0048789 name: cytoskeletal matrix organization at active zone namespace: biological_process def: "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759] is_a: GO:0030865 ! cortical cytoskeleton organization [Term] id: GO:0048790 name: maintenance of presynaptic active zone structure namespace: biological_process def: "The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators] is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0048791 name: calcium ion-dependent exocytosis of neurotransmitter namespace: biological_process def: "The release of a neurotransmitter into the synaptic cleft, where the release step is dependent on the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators] is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0048792 name: calcium ion-independent exocytosis of neurotransmitter namespace: biological_process def: "The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators] is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0048793 name: pronephros development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151] synonym: "pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0001822 ! kidney development [Term] id: GO:0048794 name: swim bladder development namespace: biological_process def: "The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] synonym: "gas bladder development" EXACT [] is_a: GO:0048513 ! organ development [Term] id: GO:0048795 name: swim bladder morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the swim bladder is generated and organized. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] synonym: "gas bladder morphogenesis" EXACT [] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0048794 ! swim bladder development [Term] id: GO:0048796 name: swim bladder maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:devbiol] synonym: "gas bladder maturation" EXACT [] is_a: GO:0048799 ! organ maturation relationship: part_of GO:0048794 ! swim bladder development [Term] id: GO:0048797 name: swim bladder formation namespace: biological_process def: "The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] synonym: "gas bladder biosynthesis" EXACT [] synonym: "gas bladder formation" EXACT [] is_a: GO:0048645 ! organ formation relationship: part_of GO:0048795 ! swim bladder morphogenesis [Term] id: GO:0048798 name: swim bladder inflation namespace: biological_process def: "The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] synonym: "gas bladder inflation" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048796 ! swim bladder maturation [Term] id: GO:0048799 name: organ maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048513 ! organ development [Term] id: GO:0048800 name: antennal morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis relationship: part_of GO:0007469 ! antennal development [Term] id: GO:0048801 name: antennal joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the antennal joint are generated and organized." [GOC:jid] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0048098 ! antennal joint development relationship: part_of GO:0048800 ! antennal morphogenesis [Term] id: GO:0048802 name: notum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007472 ! wing disc morphogenesis relationship: part_of GO:0007477 ! notum development [Term] id: GO:0048803 name: imaginal disc-derived male genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] synonym: "male genital morphogenesis" BROAD [] is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis is_a: GO:0048808 ! male genitalia morphogenesis relationship: part_of GO:0007485 ! imaginal disc-derived male genitalia development [Term] id: GO:0048804 name: imaginal disc-derived female genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of female genitalia are generated and organized from the genital disc." [GOC:ai, GOC:sensu] synonym: "female genital morphogenesis" BROAD [] is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis is_a: GO:0048807 ! female genitalia morphogenesis relationship: part_of GO:0007486 ! imaginal disc-derived female genitalia development [Term] id: GO:0048805 name: imaginal disc-derived genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] synonym: "genital morphogenesis" BROAD [] is_a: GO:0035126 ! post-embryonic genitalia morphogenesis relationship: part_of GO:0007483 ! genital disc morphogenesis relationship: part_of GO:0007484 ! imaginal disc-derived genitalia development [Term] id: GO:0048806 name: genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid] synonym: "genital development" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048513 ! organ development relationship: part_of GO:0007548 ! sex differentiation [Term] id: GO:0048807 name: female genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of female genitalia are generated and organized." [GOC:mah] synonym: "female genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis relationship: part_of GO:0030540 ! female genitalia development [Term] id: GO:0048808 name: male genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of male genitalia are generated and organized." [GOC:ems, ISBN:0140512888] synonym: "male genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis relationship: part_of GO:0030539 ! male genitalia development [Term] id: GO:0048809 name: analia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of analia are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007483 ! genital disc morphogenesis relationship: part_of GO:0007487 ! analia development [Term] id: GO:0048810 name: female analia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] is_a: GO:0048809 ! analia morphogenesis relationship: part_of GO:0045497 ! female analia development [Term] id: GO:0048811 name: male analia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc." [GOC:mtg_sensu, PMID:11494318] is_a: GO:0048809 ! analia morphogenesis relationship: part_of GO:0045496 ! male analia development [Term] id: GO:0048812 name: neuron projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0048858 ! cell projection morphogenesis relationship: part_of GO:0031175 ! neuron projection development [Term] id: GO:0048813 name: dendrite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048812 ! neuron projection morphogenesis relationship: part_of GO:0016358 ! dendrite development relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation [Term] id: GO:0048814 name: regulation of dendrite morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0050773 ! regulation of dendrite development relationship: regulates GO:0048813 ! dendrite morphogenesis [Term] id: GO:0048815 name: hermaphrodite genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of hermaphrodite genitalia are generated and organized." [GOC:ems, ISBN:0140512888] is_a: GO:0035112 ! genitalia morphogenesis relationship: part_of GO:0040035 ! hermaphrodite genitalia development [Term] id: GO:0048816 name: ocellus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis relationship: part_of GO:0008056 ! ocellus development [Term] id: GO:0048817 name: negative regulation of hair follicle maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] synonym: "down regulation of hair follicle maturation" EXACT [] synonym: "down-regulation of hair follicle maturation" EXACT [] synonym: "downregulation of hair follicle maturation" EXACT [] synonym: "inhibition of hair follicle maturation" NARROW [] is_a: GO:0048819 ! regulation of hair follicle maturation is_a: GO:0051799 ! negative regulation of hair follicle development relationship: negatively_regulates GO:0048820 ! hair follicle maturation [Term] id: GO:0048818 name: positive regulation of hair follicle maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] synonym: "activation of hair follicle maturation" NARROW [] synonym: "stimulation of hair follicle maturation" NARROW [] synonym: "up regulation of hair follicle maturation" EXACT [] synonym: "up-regulation of hair follicle maturation" EXACT [] synonym: "upregulation of hair follicle maturation" EXACT [] is_a: GO:0048819 ! regulation of hair follicle maturation is_a: GO:0051798 ! positive regulation of hair follicle development relationship: positively_regulates GO:0048820 ! hair follicle maturation [Term] id: GO:0048819 name: regulation of hair follicle maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] is_a: GO:0051797 ! regulation of hair follicle development relationship: regulates GO:0048820 ! hair follicle maturation [Term] id: GO:0048820 name: hair follicle maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state." [GOC:devbiol] is_a: GO:0022405 ! hair cycle process is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0001942 ! hair follicle development [Term] id: GO:0048821 name: erythrocyte development namespace: biological_process def: "The process aimed at the progression of an erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] synonym: "RBC development" EXACT [CL:0000232] synonym: "red blood cell development" EXACT [CL:0000232] is_a: GO:0048468 ! cell development relationship: part_of GO:0030218 ! erythrocyte differentiation [Term] id: GO:0048822 name: enucleate erythrocyte development namespace: biological_process def: "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] synonym: "enucleate RBC development" EXACT [CL:0000232] synonym: "enucleate red blood cell development" EXACT [CL:0000232] is_a: GO:0048821 ! erythrocyte development relationship: part_of GO:0043353 ! enucleate erythrocyte differentiation [Term] id: GO:0048823 name: nucleate erythrocyte development namespace: biological_process def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] synonym: "nucleate RBC development" EXACT [CL:0000232] synonym: "nucleate red blood cell development" EXACT [CL:0000232] is_a: GO:0048821 ! erythrocyte development relationship: part_of GO:0043363 ! nucleate erythrocyte differentiation [Term] id: GO:0048824 name: pigment cell precursor differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a pigment cell precursor." [GOC:dgh, PMID:16499899] synonym: "chromatophore precursor differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048825 name: cotyledon development namespace: biological_process def: "The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030] is_a: GO:0009793 ! embryo development ending in seed dormancy is_a: GO:0048827 ! phyllome development [Term] id: GO:0048826 name: cotyledon morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cotyledon are generated and organized. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048825 ! cotyledon development [Term] id: GO:0048827 name: phyllome development namespace: biological_process def: "The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants." [GOC:devbiol, GOC:tb, PO:0006001] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048367 ! shoot development [Term] id: GO:0048829 name: root cap development namespace: biological_process def: "The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant." [GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048364 ! root development [Term] id: GO:0048830 name: adventitious root development namespace: biological_process def: "The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot." [GOC:tb] is_a: GO:0048364 ! root development [Term] id: GO:0048831 name: regulation of shoot development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of shoot development." [GOC:tb, PMID:16361392] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0048367 ! shoot development [Term] id: GO:0048832 name: specification of organ number namespace: biological_process def: "The regionalization process that modulates the quantity of a particular type of organ." [GOC:dph, GOC:isa_complete, GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0048833 name: specification of floral organ number namespace: biological_process def: "Any process that modulates the number of floral organs formed in a floral whorl." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048832 ! specification of organ number relationship: part_of GO:0009908 ! flower development [Term] id: GO:0048834 name: specification of petal number namespace: biological_process def: "Any process that modulates the number of petals formed in a flower." [GOC:tb] is_a: GO:0048833 ! specification of floral organ number relationship: part_of GO:0048465 ! corolla development [Term] id: GO:0048835 name: specification of decreased petal number namespace: biological_process def: "Any process that reduces the number of petals produced in a developing flower." [GOC:tb] is_a: GO:0048834 ! specification of petal number [Term] id: GO:0048836 name: specification of increased petal number namespace: biological_process def: "Any process that increases the number of petals produced in a developing flower." [GOC:tb] is_a: GO:0048834 ! specification of petal number [Term] id: GO:0048837 name: sorus development namespace: biological_process def: "The process whose specific outcome is the progression of the sorus over time, from its formation to the mature structure. A sorus is a mass of spores." [dictyBase_REF:2530 "DictyBase paper repository", GOC:devbiol, GOC:mtg_sensu] synonym: "sorus biosynthesis" EXACT [] synonym: "sorus formation" EXACT [] synonym: "spore head biosynthesis" EXACT [] synonym: "spore head formation" EXACT [] synonym: "spore head morphogenesis" EXACT [] is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0031154 ! culmination involved in sorocarp development [Term] id: GO:0048838 name: release of seed from dormancy namespace: biological_process def: "The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release." [GOC:dph, GOC:jid, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022611 ! dormancy process relationship: part_of GO:0010162 ! seed dormancy [Term] id: GO:0048839 name: inner ear development namespace: biological_process def: "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure." [GOC:sr] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043583 ! ear development [Term] id: GO:0048840 name: otolith development namespace: biological_process def: "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure." [GOC:sr] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048839 ! inner ear development [Term] id: GO:0048841 name: regulation of axon extension involved in axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] is_a: GO:0030516 ! regulation of axon extension is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:0051270 ! regulation of cellular component movement relationship: regulates GO:0048846 ! axon extension involved in axon guidance [Term] id: GO:0048842 name: positive regulation of axon extension involved in axon guidance namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] synonym: "activation of axon extension involved in axon guidance" NARROW [] synonym: "stimulation of axon extension involved in axon guidance" NARROW [] synonym: "up regulation of axon extension involved in axon guidance" EXACT [] synonym: "up-regulation of axon extension involved in axon guidance" EXACT [] synonym: "upregulation of axon extension involved in axon guidance" EXACT [] is_a: GO:0045773 ! positive regulation of axon extension is_a: GO:0048841 ! regulation of axon extension involved in axon guidance is_a: GO:0050921 ! positive regulation of chemotaxis relationship: positively_regulates GO:0048846 ! axon extension involved in axon guidance [Term] id: GO:0048843 name: negative regulation of axon extension involved in axon guidance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] synonym: "down regulation of axon extension involved in axon guidance" EXACT [] synonym: "down-regulation of axon extension involved in axon guidance" EXACT [] synonym: "downregulation of axon extension involved in axon guidance" EXACT [] synonym: "inhibition of axon extension involved in axon guidance" NARROW [] is_a: GO:0030517 ! negative regulation of axon extension is_a: GO:0048841 ! regulation of axon extension involved in axon guidance is_a: GO:0050922 ! negative regulation of chemotaxis relationship: negatively_regulates GO:0048846 ! axon extension involved in axon guidance [Term] id: GO:0048844 name: artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480] synonym: "arterial morphogenesis" EXACT [] synonym: "arteriogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0060840 ! artery development [Term] id: GO:0048845 name: venous blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480] synonym: "vein morphogenesis" BROAD [] synonym: "venous morphogenesis" EXACT [] is_a: GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0060841 ! venous blood vessel development [Term] id: GO:0048846 name: axon extension involved in axon guidance namespace: biological_process def: "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid] is_a: GO:0048675 ! axon extension relationship: part_of GO:0007411 ! axon guidance [Term] id: GO:0048847 name: adenohypophysis formation namespace: biological_process def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis biosynthesis" EXACT [] synonym: "adenophysis formation" EXACT [] synonym: "anterior pituitary biosynthesis" EXACT [] synonym: "anterior pituitary formation" EXACT [] synonym: "anterior pituitary gland biosynthesis" EXACT [] synonym: "anterior pituitary gland formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048855 ! adenohypophysis morphogenesis [Term] id: GO:0048848 name: neurohypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis morphogenesis" EXACT [] synonym: "posterior pituitary gland morphogenesis" EXACT [] synonym: "posterior pituitary morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021985 ! neurohypophysis development relationship: part_of GO:0048850 ! hypophysis morphogenesis [Term] id: GO:0048849 name: neurohypophysis formation namespace: biological_process def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis biosynthesis" EXACT [] synonym: "neurophysis formation" EXACT [] synonym: "posterior pituitary biosynthesis" EXACT [] synonym: "posterior pituitary formation" EXACT [] synonym: "posterior pituitary gland biosynthesis" EXACT [] synonym: "posterior pituitary gland formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048848 ! neurohypophysis morphogenesis [Term] id: GO:0048850 name: hypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "pituitary gland morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021983 ! pituitary gland development relationship: part_of GO:0022612 ! gland morphogenesis relationship: part_of GO:0048852 ! diencephalon morphogenesis [Term] id: GO:0048851 name: hypophysis formation namespace: biological_process def: "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "hypophysis biosynthesis" EXACT [] synonym: "pituitary gland biosynthesis" EXACT [] synonym: "pituitary gland formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048850 ! hypophysis morphogenesis [Term] id: GO:0048852 name: diencephalon morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0048853 ! forebrain morphogenesis [Term] id: GO:0048853 name: forebrain morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "prosencephalon morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0030900 ! forebrain development relationship: part_of GO:0048854 ! brain morphogenesis [Term] id: GO:0048854 name: brain morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0007420 ! brain development [Term] id: GO:0048855 name: adenohypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis morphogenesis" EXACT [] synonym: "anterior pituitary gland morphogenesis" EXACT [] synonym: "anterior pituitary morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021984 ! adenohypophysis development relationship: part_of GO:0048850 ! hypophysis morphogenesis [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. subset: goslim_generic synonym: "development of an anatomical structure" EXACT [] is_a: GO:0032502 ! developmental process [Term] id: GO:0048857 name: neural nucleus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0048858 name: cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030030 ! cell projection organization is_a: GO:0032990 ! cell part morphogenesis relationship: part_of GO:0000902 ! cell morphogenesis [Term] id: GO:0048859 name: formation of anatomical boundary namespace: biological_process def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0048860 name: glioblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol] is_a: GO:0051301 ! cell division [Term] id: GO:0048861 name: leukemia inhibitory factor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands." [GOC:devbiol] synonym: "leukemia inhibitory factor signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0048863 name: stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] xref: Wikipedia:Stem_cell_differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048864 name: stem cell development namespace: biological_process def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete] is_a: GO:0048468 ! cell development relationship: part_of GO:0048863 ! stem cell differentiation [Term] id: GO:0048865 name: stem cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0048863 ! stem cell differentiation [Term] id: GO:0048866 name: stem cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [CL:0000034, GOC:isa_complete] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0048865 ! stem cell fate commitment [Term] id: GO:0048867 name: stem cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000034, GOC:isa_complete] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0048865 ! stem cell fate commitment [Term] id: GO:0048868 name: pollen tube development namespace: biological_process def: "The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure." [GOC:isa_complete] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035295 ! tube development relationship: part_of GO:0009856 ! pollination [Term] id: GO:0048869 name: cellular developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0009987 ! cellular process is_a: GO:0032502 ! developmental process [Term] id: GO:0048870 name: cell motility namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] subset: goslim_generic subset: gosubset_prok synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0006928 ! cellular component movement is_a: GO:0040011 ! locomotion relationship: part_of GO:0051674 ! localization of cell [Term] id: GO:0048871 name: multicellular organismal homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0042592 ! homeostatic process [Term] id: GO:0048872 name: homeostasis of number of cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] synonym: "cell population homeostasis" EXACT [] synonym: "homeostasis of cell number" EXACT [GOC:dph] is_a: GO:0042592 ! homeostatic process [Term] id: GO:0048873 name: homeostasis of number of cells within a tissue namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." [GOC:isa_complete] is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0048874 name: homeostasis of number of cells in a free-living population namespace: biological_process def: "The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0048872 ! homeostasis of number of cells is_a: GO:0051704 ! multi-organism process [Term] id: GO:0048875 name: chemical homeostasis within a tissue namespace: biological_process def: "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue." [GOC:isa_complete] is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0048876 name: chemical homeostasis within retina namespace: biological_process def: "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the retina." [GOC:isa_complete] is_a: GO:0001895 ! retina homeostasis is_a: GO:0048875 ! chemical homeostasis within a tissue [Term] id: GO:0048877 name: homeostasis of number of retina cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina." [GOC:dph, GOC:isa_complete, GOC:tb] is_a: GO:0001895 ! retina homeostasis is_a: GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0048878 name: chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0042592 ! homeostatic process [Term] id: GO:0048880 name: sensory system development namespace: biological_process def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh] is_a: GO:0048731 ! system development [Term] id: GO:0048881 name: mechanosensory lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509] synonym: "LL system development" EXACT [ISBN:0125296509] is_a: GO:0048925 ! lateral line system development [Term] id: GO:0048882 name: lateral line development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [ISBN:0125296509] synonym: "LL development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048925 ! lateral line system development [Term] id: GO:0048883 name: neuromast primordium migration namespace: biological_process def: "The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop." [PMID:15018940, PMID:15832385] synonym: "lateral line primordium migration" EXACT [] is_a: GO:0016477 ! cell migration relationship: part_of GO:0048882 ! lateral line development [Term] id: GO:0048884 name: neuromast development namespace: biological_process def: "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0048882 ! lateral line development [Term] id: GO:0048885 name: neuromast deposition namespace: biological_process def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line." [PMID:15018940] is_a: GO:0030336 ! negative regulation of cell migration relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048886 name: neuromast hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [CL:0000856, ISBN:0125296509] is_a: GO:0042490 ! mechanoreceptor differentiation relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048887 name: cupula development namespace: biological_process def: "The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048888 name: neuromast mantle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048889 name: neuromast support cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0125296509] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048890 name: lateral line ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear." [ISBN:0125296509, ISBN:0387968377] synonym: "gLL ganglion development" EXACT [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0007422 ! peripheral nervous system development relationship: part_of GO:0048925 ! lateral line system development [Term] id: GO:0048891 name: lateral line ganglion neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron." [PMID:15018940] synonym: "gLL neuron differentiation" EXACT [] is_a: GO:0048934 ! peripheral nervous system neuron differentiation relationship: part_of GO:0048890 ! lateral line ganglion development [Term] id: GO:0048892 name: lateral line nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [ISBN:0125296509] synonym: "nLL development" EXACT [] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0048925 ! lateral line system development [Term] id: GO:0048893 name: afferent axon development in lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve." [PMID:15832385] is_a: GO:0048936 ! peripheral nervous system neuron axonogenesis relationship: part_of GO:0048892 ! lateral line nerve development [Term] id: GO:0048894 name: efferent axon development in a lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve." [PMID:15832385] is_a: GO:0021955 ! central nervous system neuron axonogenesis relationship: part_of GO:0048892 ! lateral line nerve development [Term] id: GO:0048895 name: lateral line nerve glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve." [PMID:12062041] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0048892 ! lateral line nerve development [Term] id: GO:0048896 name: lateral line nerve glial cell migration namespace: biological_process def: "The movement of a glial cell along the axons in a lateral line nerve." [PMID:12062041] synonym: "glial cell migration in lateral line nerve" EXACT [GOC:curators] is_a: GO:0008347 ! glial cell migration relationship: part_of GO:0048892 ! lateral line nerve development [Term] id: GO:0048897 name: myelination of lateral line nerve axons namespace: biological_process def: "The formation of compact myelin sheaths around the axons of a lateral line nerve." [PMID:12112375] is_a: GO:0042552 ! myelination relationship: part_of GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation [Term] id: GO:0048898 name: anterior lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] synonym: "ALL system development" RELATED [] is_a: GO:0048925 ! lateral line system development relationship: part_of GO:0048881 ! mechanosensory lateral line system development [Term] id: GO:0048899 name: anterior lateral line development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] synonym: "anterior LL development" EXACT [] is_a: GO:0048882 ! lateral line development relationship: part_of GO:0048898 ! anterior lateral line system development [Term] id: GO:0048900 name: anterior lateral line neuromast primordium migration namespace: biological_process def: "The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385] synonym: "ALL neuromast primordium migration" EXACT [] is_a: GO:0048883 ! neuromast primordium migration relationship: part_of GO:0048899 ! anterior lateral line development [Term] id: GO:0048901 name: anterior lateral line neuromast development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] is_a: GO:0048884 ! neuromast development relationship: part_of GO:0048899 ! anterior lateral line development [Term] id: GO:0048902 name: anterior lateral line neuromast deposition namespace: biological_process def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line." [PMID:15832385] is_a: GO:0048885 ! neuromast deposition relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048903 name: anterior lateral line neuromast hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509, ISBN:0387968377] is_a: GO:0048886 ! neuromast hair cell differentiation relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048904 name: anterior lateral line neuromast cupula development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] is_a: GO:0048887 ! cupula development relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048905 name: anterior lateral line neuromast mantle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] is_a: GO:0048888 ! neuromast mantle cell differentiation relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048906 name: anterior lateral line neuromast support cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] is_a: GO:0048889 ! neuromast support cell differentiation relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048907 name: anterior lateral line ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] synonym: "gALL development" EXACT [] is_a: GO:0048890 ! lateral line ganglion development relationship: part_of GO:0048898 ! anterior lateral line system development [Term] id: GO:0048908 name: anterior lateral line ganglion neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion." [PMID:15018940] is_a: GO:0048891 ! lateral line ganglion neuron differentiation relationship: part_of GO:0048907 ! anterior lateral line ganglion development [Term] id: GO:0048909 name: anterior lateral line nerve development namespace: biological_process alt_id: GO:0021734 def: "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0125296509] comment: This term was added by GO_REF:0000021. synonym: "ALLN development" EXACT [] synonym: "nALL development" EXACT [] synonym: "rostral lateral line nerve development" EXACT [] is_a: GO:0048892 ! lateral line nerve development relationship: part_of GO:0048898 ! anterior lateral line system development [Term] id: GO:0048910 name: afferent axon development in anterior lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve." [PMID:15018940] is_a: GO:0048893 ! afferent axon development in lateral line nerve relationship: part_of GO:0048909 ! anterior lateral line nerve development [Term] id: GO:0048911 name: efferent axon development in anterior lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve." [PMID:15018940] is_a: GO:0048894 ! efferent axon development in a lateral line nerve relationship: part_of GO:0048909 ! anterior lateral line nerve development [Term] id: GO:0048912 name: glial cell migration in anterior lateral line nerve namespace: biological_process def: "The movement of a glial cell along the axons in the anterior lateral line nerve." [PMID:12062041] is_a: GO:0048896 ! lateral line nerve glial cell migration relationship: part_of GO:0048909 ! anterior lateral line nerve development [Term] id: GO:0048913 name: anterior lateral line nerve glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve." [PMID:15832385] is_a: GO:0048895 ! lateral line nerve glial cell differentiation relationship: part_of GO:0048909 ! anterior lateral line nerve development [Term] id: GO:0048914 name: myelination of anterior lateral line nerve axons namespace: biological_process def: "The formation of compact myelin sheaths around the axons of the anterior lateral line nerve." [PMID:12112375] is_a: GO:0048897 ! myelination of lateral line nerve axons relationship: part_of GO:0048940 ! anterior lateral line nerve glial cell morphogenesis involved in differentiation [Term] id: GO:0048915 name: posterior lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] synonym: "PLL" RELATED [] is_a: GO:0048925 ! lateral line system development relationship: part_of GO:0048881 ! mechanosensory lateral line system development [Term] id: GO:0048916 name: posterior lateral line development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509] synonym: "PLL development" EXACT [] is_a: GO:0048882 ! lateral line development relationship: part_of GO:0048915 ! posterior lateral line system development [Term] id: GO:0048917 name: posterior lateral line ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509, ISBN:0387968377] synonym: "gPLL development" EXACT [] is_a: GO:0048890 ! lateral line ganglion development relationship: part_of GO:0048915 ! posterior lateral line system development [Term] id: GO:0048918 name: posterior lateral line nerve development namespace: biological_process alt_id: GO:0021733 def: "The process whose specific outcome is the progression of the posterior lateral line nerve over time, form its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0125296509] comment: This term was added by GO_REF:0000021. synonym: "caudal lateral line nerve development" EXACT [] synonym: "PLLN development" EXACT [] is_a: GO:0048892 ! lateral line nerve development relationship: part_of GO:0048915 ! posterior lateral line system development [Term] id: GO:0048919 name: posterior lateral line neuromast development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] is_a: GO:0048884 ! neuromast development relationship: part_of GO:0048916 ! posterior lateral line development [Term] id: GO:0048920 name: posterior lateral line neuromast primordium migration namespace: biological_process def: "The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385] synonym: "PLL neuromast primordium migration" EXACT [] is_a: GO:0048883 ! neuromast primordium migration relationship: part_of GO:0048916 ! posterior lateral line development [Term] id: GO:0048921 name: posterior lateral line neuromast cupula development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] is_a: GO:0048887 ! cupula development relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048922 name: posterior lateral line neuromast deposition namespace: biological_process def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line." [PMID:15832385] is_a: GO:0048885 ! neuromast deposition relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048923 name: posterior lateral line neuromast hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509] is_a: GO:0048886 ! neuromast hair cell differentiation relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048924 name: posterior lateral line neuromast mantle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] is_a: GO:0048888 ! neuromast mantle cell differentiation relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048925 name: lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear." [GOC:dgh, ISBN:0125296509] is_a: GO:0048880 ! sensory system development [Term] id: GO:0048926 name: electrosensory lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0048925 ! lateral line system development [Term] id: GO:0048927 name: posterior lateral line neuromast support cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] is_a: GO:0048889 ! neuromast support cell differentiation relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048928 name: posterior lateral line ganglion neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion." [PMID:15018940] is_a: GO:0048891 ! lateral line ganglion neuron differentiation relationship: part_of GO:0048917 ! posterior lateral line ganglion development [Term] id: GO:0048929 name: efferent axon development in posterior lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve." [PMID:15018940] is_a: GO:0048894 ! efferent axon development in a lateral line nerve relationship: part_of GO:0048918 ! posterior lateral line nerve development [Term] id: GO:0048930 name: glial cell migration in posterior lateral line nerve namespace: biological_process def: "The movement of a glial cell along the axons in the posterior lateral line nerve." [PMID:12062041] is_a: GO:0048896 ! lateral line nerve glial cell migration relationship: part_of GO:0048918 ! posterior lateral line nerve development [Term] id: GO:0048931 name: posterior lateral line nerve glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve." [PMID:15832385] is_a: GO:0048895 ! lateral line nerve glial cell differentiation relationship: part_of GO:0048918 ! posterior lateral line nerve development [Term] id: GO:0048932 name: myelination of posterior lateral line nerve axons namespace: biological_process def: "The formation of compact myelin sheaths around the axons of the posterior lateral line nerve." [PMID:12112375] is_a: GO:0048897 ! myelination of lateral line nerve axons relationship: part_of GO:0048942 ! posterior lateral line nerve glial cell morphogenesis involved in differentiation [Term] id: GO:0048933 name: afferent axon development in posterior lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve." [PMID:15018940] is_a: GO:0048893 ! afferent axon development in lateral line nerve relationship: part_of GO:0048918 ! posterior lateral line nerve development [Term] id: GO:0048934 name: peripheral nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh] is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0007422 ! peripheral nervous system development [Term] id: GO:0048935 name: peripheral nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] is_a: GO:0048666 ! neuron development relationship: part_of GO:0048934 ! peripheral nervous system neuron differentiation [Term] id: GO:0048936 name: peripheral nervous system neuron axonogenesis namespace: biological_process def: "Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells." [GOC:dgh] is_a: GO:0007409 ! axonogenesis relationship: part_of GO:0048935 ! peripheral nervous system neuron development [Term] id: GO:0048937 name: lateral line nerve glial cell development namespace: biological_process def: "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0048895 ! lateral line nerve glial cell differentiation [Term] id: GO:0048938 name: lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0048937 ! lateral line nerve glial cell development [Term] id: GO:0048939 name: anterior lateral line nerve glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] is_a: GO:0048937 ! lateral line nerve glial cell development relationship: part_of GO:0048913 ! anterior lateral line nerve glial cell differentiation [Term] id: GO:0048940 name: anterior lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh] is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation relationship: part_of GO:0048939 ! anterior lateral line nerve glial cell development [Term] id: GO:0048941 name: posterior lateral line nerve glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] is_a: GO:0048937 ! lateral line nerve glial cell development relationship: part_of GO:0048931 ! posterior lateral line nerve glial cell differentiation [Term] id: GO:0048942 name: posterior lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh] is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation relationship: part_of GO:0048941 ! posterior lateral line nerve glial cell development [Term] id: GO:0050000 name: chromosome localization namespace: biological_process def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chromosome localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chromosome localization" EXACT [] synonym: "establishment and maintenance of chromosome position" EXACT [] is_a: GO:0051640 ! organelle localization [Term] id: GO:0050001 name: D-glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate." [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN] synonym: "D-glutamine amidohydrolase activity" EXACT [EC:3.5.1.35] xref: EC:3.5.1.35 xref: MetaCyc:D-GLUTAMINASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050002 name: D-proline reductase (dithiol) activity namespace: molecular_function def: "Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline." [EC:1.21.4.1, MetaCyc:D-PROLINE-REDUCTASE-(DITHIOL)-RXN] comment: Note that this function was formerly EC:1.4.4.1. synonym: "5-aminopentanoate:lipoate oxidoreductase (cyclizing)" EXACT [EC:1.21.4.1] xref: EC:1.21.4.1 xref: MetaCyc:1.21.4.1-RXN is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: GO:0050003 name: deoxycytidylate C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate." [EC:2.1.1.54, RHEA:11571] synonym: "5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity" EXACT [EC:2.1.1.54] synonym: "dCMP methyltransferase activity" EXACT [EC:2.1.1.54] synonym: "deoxycytidylate methyltransferase activity" EXACT [EC:2.1.1.54] xref: EC:2.1.1.54 xref: KEGG:R01670 xref: MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN xref: RHEA:11571 is_a: GO:0008169 ! C-methyltransferase activity [Term] id: GO:0050004 name: isoflavone 7-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside." [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "UDPglucose-flavonoid 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] xref: EC:2.4.1.170 xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050005 name: isohexenylglutaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H(2)O." [EC:4.2.1.57, RHEA:24147] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]" RELATED [EC:4.2.1.57] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.57] synonym: "3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity" EXACT [EC:4.2.1.57] synonym: "beta-isohexenylglutaconyl-CoA-hydratase activity" EXACT [EC:4.2.1.57] synonym: "isohexenylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.57] xref: EC:4.2.1.57 xref: KEGG:R03493 xref: MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN xref: RHEA:24147 xref: UM-BBD_reactionID:r1167 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050006 name: isomaltulose synthase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose." [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN] synonym: "isomaltulose synthetase activity" EXACT [EC:5.4.99.11] synonym: "sucrose alpha-glucosyltransferase activity" EXACT [EC:5.4.99.11] synonym: "sucrose glucosylmutase activity" EXACT [EC:5.4.99.11] synonym: "trehalulose synthase activity" EXACT [EC:5.4.99.11] xref: EC:5.4.99.11 xref: MetaCyc:ISOMALTULOSE-SYNTHASE-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0050007 name: isonocardicin synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H(+) + isonocardicin A." [EC:2.5.1.38, RHEA:19848] synonym: "nocardicin aminocarboxypropyltransferase activity" EXACT [EC:2.5.1.38] synonym: "S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.38] xref: EC:2.5.1.38 xref: KEGG:R03072 xref: MetaCyc:ISONOCARDICIN-SYNTHASE-RXN xref: RHEA:19848 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050008 name: isopiperitenone delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: isopiperitenone = piperitenone." [EC:5.3.3.11, RHEA:21519] synonym: "isopiperitenone D-isomerase activity" EXACT [] synonym: "isopiperitenone delta8-delta4-isomerase activity" EXACT [EC:5.3.3.11] xref: EC:5.3.3.11 xref: KEGG:R03782 xref: MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN xref: RHEA:21519 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0050009 name: isopropanol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + propan-2-ol = acetone + H(+) + NADPH." [EC:1.1.1.80, RHEA:21795] synonym: "propan-2-ol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.80] xref: EC:1.1.1.80 xref: KEGG:R01550 xref: MetaCyc:ISOPROPANOL-DEHYDROGENASE-NADP+-RXN xref: RHEA:21795 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050010 name: isovitexin beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: isovitexin + UDP-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP." [EC:2.4.1.106, RHEA:19532] synonym: "isovitexin b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106] synonym: "UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106] synonym: "uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.106] xref: EC:2.4.1.106 xref: KEGG:R03686 xref: MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:19532 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050011 name: itaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O." [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN] synonym: "citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" EXACT [EC:4.2.1.56] synonym: "citramalyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.56] synonym: "itaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.56] xref: EC:4.2.1.56 xref: MetaCyc:ITACONYL-COA-HYDRATASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050012 name: juglone 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxy-1,4-naphthoquinone + AH(2) + O(2) = 3,5-dihydroxy-1,4-naphthoquinone + A + H(2)O + H(+)." [EC:1.14.99.27, RHEA:18748] synonym: "5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.99.27] synonym: "juglone hydroxylase activity" EXACT [] synonym: "naphthoquinone hydroxylase activity" EXACT [EC:1.14.99.27] synonym: "naphthoquinone-hydroxylase activity" EXACT [EC:1.14.99.27] xref: EC:1.14.99.27 xref: KEGG:R04327 xref: MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN xref: RHEA:18748 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050013 name: 2-dehydropantoate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde." [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN] synonym: "2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.1.2.12] synonym: "2-dehydropantoate formaldehyde-lyase activity" EXACT [EC:4.1.2.12] synonym: "ketopantoaldolase activity" EXACT [] xref: EC:4.1.2.12 xref: MetaCyc:KETOPANTOALDOLASE-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050014 name: ketotetrose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate." [EC:4.1.2.2, RHEA:20935] synonym: "erythrose-1-phosphate synthase activity" EXACT [EC:4.1.2.2] synonym: "erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.2] synonym: "erythrulose-1-phosphate formaldehyde-lyase activity" EXACT [EC:4.1.2.2] synonym: "erythrulose-1-phosphate synthetase activity" EXACT [EC:4.1.2.2] synonym: "phosphoketotetrose aldolase activity" EXACT [EC:4.1.2.2] xref: EC:4.1.2.2 xref: KEGG:R01014 xref: MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN xref: RHEA:20935 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050015 name: kievitone hydratase activity namespace: molecular_function def: "Catalysis of the reaction: kievitone hydrate = H(2)O + H(+) + kievitone." [EC:4.2.1.95, RHEA:23607] synonym: "KHase activity" EXACT [EC:4.2.1.95] synonym: "kievitone-hydrate hydro-lyase (kievitone-forming)" EXACT [EC:4.2.1.95] synonym: "kievitone-hydrate hydro-lyase activity" EXACT [EC:4.2.1.95] xref: EC:4.2.1.95 xref: KEGG:R03622 xref: MetaCyc:KIEVITONE-HYDRATASE-RXN xref: RHEA:23607 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050016 name: kynurenine 7,8-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor." [EC:1.14.99.2, MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN] synonym: "kynurenate 7,8-hydroxylase activity" EXACT [EC:1.14.99.2] synonym: "kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.2] synonym: "kynurenic acid hydroxylase activity" EXACT [EC:1.14.99.2] synonym: "kynurenic hydroxylase activity" EXACT [EC:1.14.99.2] xref: EC:1.14.99.2 xref: MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050017 name: L-3-cyanoalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine." [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN] synonym: "beta-cyano-L-alanine synthase activity" EXACT [EC:4.4.1.9] synonym: "beta-cyanoalanine synthase activity" EXACT [EC:4.4.1.9] synonym: "beta-cyanoalanine synthetase activity" EXACT [EC:4.4.1.9] synonym: "L-cysteine hydrogen-sulfide-lyase (adding HCN)" EXACT [EC:4.4.1.9] synonym: "L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)" EXACT [EC:4.4.1.9] xref: EC:4.4.1.9 xref: MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0050018 name: L-amino-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." [EC:1.4.1.5, MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN] synonym: "L-amino-acid:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.5] xref: EC:1.4.1.5 xref: MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050019 name: L-arabinitol 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinitol + NAD(+) = L-xylulose + H(+) + NADH." [EC:1.1.1.12, RHEA:16384] xref: EC:1.1.1.12 xref: KEGG:R01903 xref: MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN xref: RHEA:16384 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050020 name: L-arabinonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O." [EC:4.2.1.25, RHEA:20971] synonym: "L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)" EXACT [EC:4.2.1.25] synonym: "L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.25] synonym: "L-arabonate dehydrase activity" EXACT [EC:4.2.1.25] synonym: "L-arabonate dehydratase activity" EXACT [EC:4.2.1.25] xref: EC:4.2.1.25 xref: KEGG:R02522 xref: MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN xref: RHEA:20971 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050021 name: L-arabinonolactonase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+)." [EC:3.1.1.15, RHEA:16220] synonym: "L-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.15] xref: EC:3.1.1.15 xref: KEGG:R02526 xref: MetaCyc:L-ARABINONOLACTONASE-RXN xref: RHEA:16220 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050022 name: L-arabinose 1-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH." [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN] synonym: "L-arabinose 1-dehydrogenase activity" BROAD [] synonym: "L-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.46] xref: EC:1.1.1.46 xref: MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050023 name: L-fuconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O." [EC:4.2.1.68, RHEA:22775] synonym: "L-fuconate hydratase activity" EXACT [] synonym: "L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)" EXACT [EC:4.2.1.68] synonym: "L-fuconate hydro-lyase activity" EXACT [EC:4.2.1.68] xref: EC:4.2.1.68 xref: KEGG:R03688 xref: MetaCyc:L-FUCONATE-HYDRATASE-RXN xref: RHEA:22775 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050024 name: L-galactonolactone oxidase activity namespace: molecular_function alt_id: GO:0033733 def: "Catalysis of the reaction: L-galactono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2) + H(+)." [EC:1.3.3.12, RHEA:20620] synonym: "L-galactono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12] synonym: "L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.3.3.12] synonym: "L-xylono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12] xref: EC:1.3.3.12 xref: KEGG:R00643 xref: MetaCyc:1.3.3.12-RXN xref: RHEA:20620 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050025 name: L-glutamate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.11, MetaCyc:L-GLUTAMATE-OXIDASE-RXN] subset: gosubset_prok synonym: "glutamate (acceptor) dehydrogenase activity" EXACT [EC:1.4.3.11] synonym: "glutamate oxidase activity" EXACT [EC:1.4.3.11] synonym: "glutamic acid oxidase activity" EXACT [EC:1.4.3.11] synonym: "glutamic dehydrogenase (acceptor)" EXACT [EC:1.4.3.11] synonym: "L-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.11] synonym: "L-glutamic acid oxidase activity" EXACT [EC:1.4.3.11] xref: EC:1.4.3.11 xref: MetaCyc:L-GLUTAMATE-OXIDASE-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0050026 name: L-glycol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+." [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN] synonym: "glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.185] synonym: "L-(+)-glycol:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.185] synonym: "L-glycol:NAD(P) dehydrogenase activity" EXACT [EC:1.1.1.185] synonym: "L-glycol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.185] xref: EC:1.1.1.185 xref: MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050027 name: L-idonate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH." [EC:1.1.1.128, MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN] synonym: "5-keto-D-gluconate 2-reductase activity" EXACT [EC:1.1.1.128] synonym: "5-ketogluconate 2-reductase activity" EXACT [EC:1.1.1.128] synonym: "5-ketoglucono-idono-reductase activity" EXACT [EC:1.1.1.128] synonym: "5KGR" RELATED [EC:1.1.1.128] synonym: "L-idonate dehydrogenase activity" EXACT [EC:1.1.1.128] synonym: "L-idonate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.128] synonym: "reductase, 5-ketogluconate 5- (L-idonate-forming)" EXACT [EC:1.1.1.128] xref: EC:1.1.1.128 xref: MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050028 name: L-lysine-lactamase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminohexano-6-lactam + H(2)O = L-lysine." [EC:3.5.2.11, RHEA:21391] synonym: "L-alpha-aminocaprolactam hydrolase activity" EXACT [EC:3.5.2.11] synonym: "L-lysinamidase activity" EXACT [EC:3.5.2.11] synonym: "L-lysine-1,6-lactam lactamhydrolase activity" EXACT [EC:3.5.2.11] xref: EC:3.5.2.11 xref: KEGG:R00463 xref: MetaCyc:L-LYSINE-LACTAMASE-RXN xref: RHEA:21391 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0050029 name: L-lysine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + H(2)O + O(2) = 6-amino-2-oxohexanoate + H(2)O(2) + NH(4)(+)." [EC:1.4.3.14, RHEA:14440] synonym: "L-lysine alpha-oxidase activity" EXACT [EC:1.4.3.14] synonym: "L-lysine:oxygen 2-oxidoreductase (deaminating)" EXACT [EC:1.4.3.14] synonym: "L-lysyl-alpha-oxidase activity" EXACT [EC:1.4.3.14] xref: EC:1.4.3.14 xref: KEGG:R00447 xref: MetaCyc:L-LYSINE-OXIDASE-RXN xref: MetaCyc:PWY-5311 xref: RHEA:14440 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0050030 name: L-pipecolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN] synonym: "L-pipecolate:(acceptor) 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3] synonym: "L-pipecolate:acceptor 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3] xref: EC:1.5.99.3 xref: MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0050031 name: L-pipecolate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.3.7, RHEA:11995] synonym: "L-pipecolate:oxygen 1,6-oxidoreductase activity" EXACT [EC:1.5.3.7] synonym: "L-pipecolic acid oxidase activity" EXACT [EC:1.5.3.7] xref: EC:1.5.3.7 xref: KEGG:R02204 xref: MetaCyc:L-PIPECOLATE-OXIDASE-RXN xref: RHEA:11995 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0050032 name: L-rhamnonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O." [EC:4.2.1.90, RHEA:23083] synonym: "L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)" EXACT [EC:4.2.1.90] synonym: "L-rhamnonate hydro-lyase activity" EXACT [EC:4.2.1.90] xref: EC:4.2.1.90 xref: KEGG:R03774 xref: MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN xref: RHEA:23083 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050033 name: L-rhamnono-1,4-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnono-1,4-lactone + H(2)O = L-rhamnonate + H(+)." [EC:3.1.1.65, RHEA:10291] synonym: "L-rhamno-gamma-lactonase activity" EXACT [EC:3.1.1.65] synonym: "L-rhamnono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.65] synonym: "L-rhamnono-gamma-lactonase activity" EXACT [EC:3.1.1.65] xref: EC:3.1.1.65 xref: KEGG:R03772 xref: MetaCyc:L-RHAMNONO-14-LACTONASE-RXN xref: RHEA:10291 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050034 name: L-rhamnose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + H(+) + NADH." [EC:1.1.1.173, RHEA:12652] synonym: "L-rhamnofuranose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.173] xref: EC:1.1.1.173 xref: KEGG:R03942 xref: MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN xref: RHEA:12652 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050035 name: L-sorbose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-sorbose + O(2) = 5-dehydro-D-fructose + H(2)O(2)." [EC:1.1.3.11, RHEA:17856] synonym: "L-sorbose:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.11] xref: EC:1.1.3.11 xref: KEGG:R01695 xref: MetaCyc:L-SORBOSE-OXIDASE-RXN xref: RHEA:17856 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050036 name: L-threonate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonate + NAD(+) = 3-dehydro-L-threonate + H(+) + NADH." [EC:1.1.1.129, RHEA:23379] synonym: "L-threonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.129] synonym: "L-threonic acid dehydrogenase activity" EXACT [EC:1.1.1.129] synonym: "threonate dehydrogenase activity" EXACT [EC:1.1.1.129] xref: EC:1.1.1.129 xref: KEGG:R03733 xref: MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN xref: RHEA:23379 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050037 name: L-xylose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: aldehydo-L-xylose + NADP(+) = L-xylono-1,4-lactone + H(+) + NADPH." [EC:1.1.1.113, RHEA:15792] synonym: "L-xylose dehydrogenase activity" EXACT [EC:1.1.1.113] synonym: "L-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.113] synonym: "NADPH-xylose reductase activity" EXACT [EC:1.1.1.113] xref: EC:1.1.1.113 xref: KEGG:R03586 xref: MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN xref: RHEA:15792 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050038 name: L-xylulose reductase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH." [EC:1.1.1.10, RHEA:17028] synonym: "L-xylulose reductase activity" BROAD [] xref: EC:1.1.1.10 xref: KEGG:R01904 xref: MetaCyc:L-XYLULOSE-REDUCTASE-RXN xref: RHEA:17028 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050039 name: lactaldehyde reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH." [EC:1.1.1.55, RHEA:15888] synonym: "1,2-propanediol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55] synonym: "lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.55] synonym: "NADP-1,2-propanediol dehydrogenase activity" EXACT [EC:1.1.1.55] synonym: "propane-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55] synonym: "propanediol dehydrogenase activity" EXACT [EC:1.1.1.55] xref: EC:1.1.1.55 xref: KEGG:R02259 xref: MetaCyc:LACTALDEHYDE-REDUCTASE-NADPH-RXN xref: RHEA:15888 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050040 name: lactate 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + O(2) = acetate + CO(2) + H(2)O." [EC:1.13.12.4, RHEA:16516] subset: gosubset_prok synonym: "(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.4] synonym: "L-lactate monooxygenase activity" EXACT [EC:1.13.12.4] synonym: "L-lactate-2-monooxygenase activity" EXACT [EC:1.13.12.4] synonym: "lactate monooxygenase activity" EXACT [EC:1.13.12.4] synonym: "lactate oxidase activity" EXACT [EC:1.13.12.4] synonym: "lactate oxidative decarboxylase activity" EXACT [EC:1.13.12.4] synonym: "lactate oxygenase activity" EXACT [EC:1.13.12.4] synonym: "lactic oxidase activity" EXACT [EC:1.13.12.4] synonym: "lactic oxygenase activity" EXACT [EC:1.13.12.4] xref: EC:1.13.12.4 xref: KEGG:R00319 xref: MetaCyc:LACTATE-2-MONOOXYGENASE-RXN xref: RHEA:16516 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050041 name: lactate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate = acetaldehyde + formate." [EC:4.1.2.36, RHEA:17912] synonym: "(S)-lactate acetaldehyde-lyase (formate-forming)" EXACT [EC:4.1.2.36] synonym: "(S)-lactate acetaldehyde-lyase activity" EXACT [EC:4.1.2.36] synonym: "lactate synthase activity" EXACT [EC:4.1.2.36] xref: EC:4.1.2.36 xref: KEGG:R00753 xref: MetaCyc:LACTATE-ALDOLASE-RXN xref: RHEA:17912 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050042 name: lactate-malate transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate." [EC:1.1.99.7, RHEA:10987] synonym: "(S)-lactate:oxaloacetate oxidoreductase activity" EXACT [EC:1.1.99.7] synonym: "malate-lactate transhydrogenase activity" EXACT [EC:1.1.99.7] xref: EC:1.1.99.7 xref: KEGG:R01447 xref: MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN xref: RHEA:10987 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0050043 name: lactate racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate = (R)-lactate." [EC:5.1.2.1, RHEA:10963] synonym: "hydroxyacid racemase activity" EXACT [EC:5.1.2.1] synonym: "lactic acid racemase activity" EXACT [EC:5.1.2.1] synonym: "lacticoracemase activity" EXACT [EC:5.1.2.1] xref: EC:5.1.2.1 xref: KEGG:R01450 xref: MetaCyc:LACTATE-RACEMASE-RXN xref: RHEA:10963 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0050044 name: galactose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate." [EC:5.3.1.26, RHEA:13036] subset: gosubset_prok synonym: "D-galactose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.26] synonym: "D-galactose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.26] xref: EC:5.3.1.26 xref: KEGG:R03240 xref: MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN xref: RHEA:13036 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0050045 name: laminaribiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.31, MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN] synonym: "3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.31] xref: EC:2.4.1.31 xref: MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0050046 name: lathosterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2." [EC:1.14.21.6, MetaCyc:LATHOSTEROL-OXIDASE-RXN] synonym: "5-DES" RELATED [EC:1.14.21.6] synonym: "5alpha-cholest-7-en-3beta-ol, NAD(P)H:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.21.6] synonym: "delta7-sterol 5-desaturase activity" EXACT [EC:1.14.21.6] synonym: "delta7-sterol delta5-dehydrogenase activity" EXACT [EC:1.14.21.6] synonym: "delta7-sterol-C5(6)-desaturase activity" EXACT [EC:1.14.21.6] synonym: "lathosterol 5-desaturase activity" EXACT [EC:1.14.21.6] xref: EC:1.14.21.6 xref: MetaCyc:1.14.21.6-RXN is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0050047 name: leucine 2,3-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine = (3R)-beta-leucine." [EC:5.4.3.7, RHEA:10287] synonym: "(2S)-alpha-leucine 2,3-aminomutase activity" EXACT [EC:5.4.3.7] xref: EC:5.4.3.7 xref: KEGG:R01091 xref: MetaCyc:LEUCINE-23-AMINOMUTASE-RXN xref: RHEA:10287 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0050048 name: L-leucine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [EC:2.6.1.6, MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN] synonym: "L-leucine aminotransferase activity" BROAD [EC:2.6.1.6] synonym: "leucine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.6] synonym: "leucine aminotransferase activity" BROAD [] synonym: "leucine transaminase activity" BROAD [EC:2.6.1.6] synonym: "leucine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.6] xref: EC:2.6.1.6 xref: MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050049 name: leucine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH." [EC:1.4.1.9, MetaCyc:LEUCINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "L-leucine dehydrogenase activity" EXACT [EC:1.4.1.9] synonym: "L-leucine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.9] synonym: "L-leucine:NAD+ oxidoreductase, deaminating" EXACT [EC:1.4.1.9] synonym: "LeuDH activity" EXACT [EC:1.4.1.9] xref: EC:1.4.1.9 xref: MetaCyc:LEUCINE-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050050 name: leucine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H(+)." [EC:2.3.1.66, RHEA:20092] synonym: "acetyl-CoA:L-leucine N-acetyltransferase activity" EXACT [EC:2.3.1.66] synonym: "leucine acetyltransferase activity" EXACT [EC:2.3.1.66] xref: EC:2.3.1.66 xref: KEGG:R01089 xref: MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN xref: RHEA:20092 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0050051 name: leukotriene-B4 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN] synonym: "(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.30] synonym: "leucotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "leukotriene-B(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "leukotriene-B(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "leukotriene-B4 20-hydroxylase activity" EXACT [] synonym: "leukotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "LTB(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "LTB(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "LTB4 20-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "LTB4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] xref: EC:1.14.13.30 xref: MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050052 name: leukotriene-E4 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + leukotriene E(4) + NADPH + O(2) = 20-hydroxy-leukotriene E(4) + H(2)O + NADP(+)." [EC:1.14.13.34, RHEA:24123] synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.34] synonym: "leukotriene-E(4) omega-hydroxylase activity" EXACT [EC:1.14.13.34] synonym: "leukotriene-E4 omega-hydroxylase activity" EXACT [EC:1.14.13.34] synonym: "leukotriene-E4 w-hydroxylase activity" EXACT [] xref: EC:1.14.13.34 xref: KEGG:R04256 xref: MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN xref: RHEA:24123 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050053 name: levansucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)." [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN] subset: gosubset_prok synonym: "beta-2,6-fructan:D-glucose 1-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "beta-2,6-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose 6-fructosyl transferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose 6-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.10] xref: EC:2.4.1.10 xref: MetaCyc:LEVANSUCRASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050054 name: lignostilbene alpha beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin." [EC:1.13.11.43, RHEA:21343] synonym: "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)" EXACT [EC:1.13.11.43] synonym: "lignostilbene ab-dioxygenase activity" EXACT [] synonym: "lignostilbene alphabeta-dioxygenase activity" EXACT [EC:1.13.11.43] xref: EC:1.13.11.43 xref: KEGG:R00043 xref: MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN xref: RHEA:21343 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050055 name: limonin-D-ring-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate." [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN] synonym: "limonin lactone hydrolase activity" EXACT [EC:3.1.1.36] synonym: "limonin-D-ring-lactone hydrolase activity" EXACT [EC:3.1.1.36] synonym: "limonoate-D-ring-lactone lactonohydrolase activity" EXACT [EC:3.1.1.36] xref: EC:3.1.1.36 xref: MetaCyc:LIMONIN-D-RING-LACTONASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050056 name: linalool 8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + linalool + O(2) = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H(2)O." [EC:1.14.99.28, RHEA:20763] subset: gosubset_prok synonym: "3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.99.28] xref: EC:1.14.99.28 xref: KEGG:R04366 xref: MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN xref: RHEA:20763 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050057 name: linamarin synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin." [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN] synonym: "UDP glucose ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "uridine diphosphoglucose-ketone glucosyltransferase activity" EXACT [EC:2.4.1.63] xref: EC:2.4.1.63 xref: MetaCyc:LINAMARIN-SYNTHASE-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050058 name: linoleate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate." [EC:5.2.1.5, RHEA:17384] synonym: "linoleate delta12-cis-delta11-trans-isomerase activity" EXACT [EC:5.2.1.5] synonym: "linoleic acid isomerase activity" EXACT [EC:5.2.1.5] xref: EC:5.2.1.5 xref: KEGG:R03627 xref: MetaCyc:LINOLEATE-ISOMERASE-RXN xref: RHEA:17384 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0050059 name: lombricine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine." [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN] synonym: "ATP:lombricine N-phosphotransferase activity" EXACT [EC:2.7.3.5] xref: EC:2.7.3.5 xref: MetaCyc:LOMBRICINE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0050060 name: long-chain-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH." [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN] synonym: "fatty alcohol oxidoreductase activity" EXACT [EC:1.1.1.192] synonym: "long-chain alcohol dehydrogenase activity" EXACT [EC:1.1.1.192] synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.192] xref: EC:1.1.1.192 xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050061 name: long-chain-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+." [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN] synonym: "fatty aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] synonym: "long-chain aliphatic aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] synonym: "long-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] xref: EC:1.2.1.48 xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r1404 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050062 name: long-chain-fatty-acyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN] subset: gosubset_prok synonym: "acyl coenzyme A reductase activity" EXACT [EC:1.2.1.50] synonym: "long-chain fatty acyl CoA reductase activity" EXACT [GOC:curators] synonym: "long-chain fatty acyl-CoA reductase activity" EXACT [GOC:mah] synonym: "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)" EXACT [EC:1.2.1.50] xref: EC:1.2.1.50 xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050063 name: low-density-lipoprotein particle receptor kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine." [EC:2.7.11.29, MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN] synonym: "[low-density lipoprotein receptor] kinase activity" EXACT [] synonym: "ATP:low-density-lipoprotein receptor-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29] synonym: "ATP:low-density-lipoprotein-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29] synonym: "LDL receptor kinase activity" EXACT [EC:2.7.11.29] synonym: "low-density lipoprotein receptor kinase activity" EXACT [EC:2.7.11.29] synonym: "low-density-lipoprotein kinase activity" BROAD [EC:2.7.11.29] synonym: "low-density-lipoprotein receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.29] synonym: "low-density-lipoprotein receptor kinase activity" EXACT [GOC:dph] synonym: "STK7" RELATED [EC:2.7.11.29] xref: EC:2.7.11.29 xref: MetaCyc:2.7.11.29-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050064 name: luteolin 7-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.189, RHEA:10571] synonym: "LGT" RELATED [EC:2.4.1.189] synonym: "luteolin 7-O-glucoronosyltransferase activity" EXACT [] synonym: "UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] synonym: "UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] xref: EC:2.4.1.189 xref: KEGG:R03589 xref: MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN xref: RHEA:10571 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0050065 name: lysine-pyruvate 6-transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine." [EC:2.6.1.71, RHEA:19396] synonym: "L-lysine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.71] synonym: "Lys-AT" RELATED [EC:2.6.1.71] synonym: "lysine--pyruvate 6-aminotransferase activity" EXACT [] synonym: "lysine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.71] xref: EC:2.6.1.71 xref: KEGG:R00453 xref: MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN xref: MetaCyc:PWY-5324 xref: RHEA:19396 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050066 name: lysine 2,3-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." [EC:5.4.3.2, RHEA:19180] subset: gosubset_prok synonym: "L-lysine 2,3-aminomutase activity" EXACT [EC:5.4.3.2] xref: EC:5.4.3.2 xref: KEGG:R00461 xref: MetaCyc:LYSINE-23-AMINOMUTASE-RXN xref: RHEA:19180 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups is_a: GO:0070283 ! radical SAM enzyme activity [Term] id: GO:0050067 name: lysine 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + O(2) = 5-aminopentanamide + CO(2) + H(2)O." [EC:1.13.12.2, RHEA:14604] synonym: "L-lysine-2-monooxygenase activity" EXACT [EC:1.13.12.2] synonym: "L-lysine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.2] synonym: "lysine monooxygenase activity" EXACT [EC:1.13.12.2] synonym: "lysine oxygenase activity" EXACT [EC:1.13.12.2] xref: EC:1.13.12.2 xref: KEGG:R00449 xref: MetaCyc:LYSINE-2-MONOOXYGENASE-RXN xref: RHEA:14604 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050068 name: lysine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H(+) + phosphate." [EC:2.1.3.8, RHEA:17124] synonym: "carbamoyl-phosphate:L-lysine carbamoyltransferase activity" EXACT [EC:2.1.3.8] synonym: "lysine transcarbamylase activity" EXACT [EC:2.1.3.8] xref: EC:2.1.3.8 xref: KEGG:R01396 xref: MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN xref: RHEA:17124 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0050069 name: lysine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH." [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN] synonym: "L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)" EXACT [EC:1.4.1.15] xref: EC:1.4.1.15 xref: MetaCyc:LYSINE-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050070 name: lysolecithin acylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine." [EC:5.4.1.1, RHEA:24359] synonym: "lysolecithin 2,3-acylmutase activity" EXACT [EC:5.4.1.1] synonym: "lysolecithin migratase activity" RELATED [EC:5.4.1.1] xref: EC:5.4.1.1 xref: KEGG:R03334 xref: MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN xref: RHEA:24359 is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0050071 name: lysyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol." [EC:2.3.2.3, MetaCyc:LYSYLTRANSFERASE-RXN] subset: gosubset_prok synonym: "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity" EXACT [EC:2.3.2.3] synonym: "L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity" EXACT [EC:2.3.2.3] xref: EC:2.3.2.3 xref: MetaCyc:LYSYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0050072 name: m7G(5')pppN diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [EC:3.6.1.30, MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN] synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [EC:3.6.1.30] synonym: "decapase activity" RELATED [EC:3.6.1.30] synonym: "M(7)G(5')pppN pyrophosphatase activity" EXACT [] synonym: "m7G(5')pppN pyrophosphatase activity" EXACT [EC:3.6.1.30] xref: EC:3.6.1.30 xref: MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0050073 name: macrolide 2'-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H(+) + oleandomycin 2'-O-phosphate." [EC:2.7.1.136, RHEA:18336] synonym: "ATP:macrolide 2'-O-phosphotransferase activity" EXACT [EC:2.7.1.136] xref: EC:2.7.1.136 xref: KEGG:R03780 xref: MetaCyc:MACROLIDE-2-KINASE-RXN xref: RHEA:18336 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050074 name: malate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA." [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN] subset: gosubset_prok synonym: "malate thiokinase activity" RELATED [EC:6.2.1.9] synonym: "malate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.9] synonym: "malyl coenzyme A synthetase activity" EXACT [EC:6.2.1.9] synonym: "malyl-CoA synthetase activity" EXACT [EC:6.2.1.9] xref: EC:6.2.1.9 xref: MetaCyc:MALATE--COA-LIGASE-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050075 name: maleate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-malate = H(2)O + maleate." [EC:4.2.1.31, RHEA:23695] synonym: "(R)-malate hydro-lyase (maleate-forming)" EXACT [EC:4.2.1.31] synonym: "(R)-malate hydro-lyase activity" EXACT [EC:4.2.1.31] synonym: "D-malate hydro-lyase activity" EXACT [EC:4.2.1.31] synonym: "malease activity" EXACT [EC:4.2.1.31] xref: EC:4.2.1.31 xref: KEGG:R02419 xref: MetaCyc:MALEATE-HYDRATASE-RXN xref: RHEA:23695 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050076 name: maleate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: maleate = fumarate." [EC:5.2.1.1, RHEA:13172] subset: gosubset_prok synonym: "maleate cis-trans-isomerase activity" EXACT [EC:5.2.1.1] xref: EC:5.2.1.1 xref: KEGG:R01087 xref: MetaCyc:MALEATE-ISOMERASE-RXN xref: RHEA:13172 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0050077 name: maleylpyruvate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate." [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN] subset: gosubset_prok synonym: "3-maleylpyruvate cis-trans-isomerase activity" EXACT [EC:5.2.1.4] xref: EC:5.2.1.4 xref: MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0050078 name: malonate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA." [EC:2.8.3.3, RHEA:18820] synonym: "acetyl-CoA:malonate CoA-transferase activity" EXACT [EC:2.8.3.3] synonym: "malonate coenzyme A-transferase activity" EXACT [EC:2.8.3.3] xref: EC:2.8.3.3 xref: KEGG:R00743 xref: MetaCyc:MALONATE-COA-TRANSFERASE-RXN xref: RHEA:18820 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0050079 name: acetylenecarboxylate hydratase activity, producing 3-oxopropanoate namespace: molecular_function alt_id: GO:0047607 def: "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O." [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN] comment: Note that this function was formerly EC:4.2.1.71. synonym: "3-oxopropanoate hydro-lyase (propynoate-forming)" EXACT [EC:4.2.1.27] synonym: "3-oxopropanoate hydro-lyase activity" EXACT [EC:4.2.1.27] synonym: "acetylenecarboxylate hydratase activity" BROAD [] synonym: "acetylenecarboxylate hydratase activity, producing malonate-semialdehyde" EXACT [] synonym: "acetylenemonocarboxylate hydrase activity" EXACT [EC:4.2.1.27] synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] synonym: "acetylmonocarboxylic acid hydrase activity" EXACT [EC:4.2.1.27] synonym: "alkynoate hydratase activity" BROAD [] synonym: "malonate-semialdehyde dehydratase activity" EXACT [] xref: EC:4.2.1.27 xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050080 name: malonyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "malonyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.9] synonym: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.1.9] synonym: "malonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.9] xref: EC:4.1.1.9 xref: MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050081 name: maltose-6'-phosphate glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.122, MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN] subset: gosubset_prok synonym: "maltose-6'-phosphate 6-phosphoglucohydrolase activity" EXACT [EC:3.2.1.122] synonym: "phospho-alpha-glucosidase activity" EXACT [EC:3.2.1.122] xref: EC:3.2.1.122 xref: MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0050082 name: maltose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN] subset: gosubset_prok synonym: "maltose:phosphate 1-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.8] xref: EC:2.4.1.8 xref: MetaCyc:MALTOSE-PHOSPHORYLASE-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0050083 name: malyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate." [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN] synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.24] synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity" EXACT [EC:4.1.3.24] synonym: "malyl-coenzyme A lyase activity" EXACT [EC:4.1.3.24] xref: EC:4.1.3.24 xref: MetaCyc:MALYL-COA-LYASE-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0050084 name: mannitol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + H(2)O = D-mannitol + 2 H(+) + phosphate." [EC:3.1.3.22, RHEA:19540] synonym: "D-mannitol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.22] synonym: "mannitol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.22] xref: EC:3.1.3.22 xref: KEGG:R02167 xref: MetaCyc:MANNITOL-1-PHOSPHATASE-RXN xref: RHEA:19540 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050085 name: mannitol 2-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH." [EC:1.1.1.138, RHEA:16768] synonym: "D-mannitol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.138] synonym: "NADP-dependent mannitol dehydrogenase activity" EXACT [EC:1.1.1.138] xref: EC:1.1.1.138 xref: KEGG:R00870 xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-NADP+-RXN xref: RHEA:16768 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050086 name: mannitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH." [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "D-mannitol dehydrogenase activity" EXACT [EC:1.1.1.67] synonym: "D-mannitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.67] xref: EC:1.1.1.67 xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050087 name: mannitol dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c." [EC:1.1.2.2, MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN] synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.2] synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2] xref: EC:1.1.2.2 xref: MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0050088 name: mannose-6-phosphate 6-reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + 3 H(+) + NADPH." [EC:1.1.1.224, RHEA:14928] synonym: "6-phosphomannose reductase activity" EXACT [EC:1.1.1.224] synonym: "D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.224] synonym: "mannose-6-phosphate reductase activity" EXACT [EC:1.1.1.224] synonym: "NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity" EXACT [EC:1.1.1.224] synonym: "NADPH-dependent M6P reductase activity" EXACT [EC:1.1.1.224] synonym: "NADPH-dependent mannose 6-phosphate reductase activity" EXACT [EC:1.1.1.224] synonym: "NADPH-mannose-6-P reductase activity" EXACT [EC:1.1.1.224] xref: EC:1.1.1.224 xref: KEGG:R01817 xref: MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN xref: RHEA:14928 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050089 name: mannose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannose = D-fructose." [EC:5.3.1.7, RHEA:22607] synonym: "D-mannose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.7] synonym: "D-mannose isomerase activity" EXACT [EC:5.3.1.7] synonym: "D-mannose ketol-isomerase activity" EXACT [EC:5.3.1.7] xref: EC:5.3.1.7 xref: KEGG:R00877 xref: MetaCyc:MANNOSE-ISOMERASE-RXN xref: RHEA:22607 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0050090 name: mannuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+." [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN] synonym: "D-mannonate:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.131] synonym: "D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))" EXACT [EC:1.1.1.131] synonym: "mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity" EXACT [EC:1.1.1.131] synonym: "mannonate dehydrogenase (NAD(P)+)" EXACT [EC:1.1.1.131] synonym: "mannonate dehydrogenase activity" EXACT [EC:1.1.1.131] xref: EC:1.1.1.131 xref: MetaCyc:MANNURONATE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050091 name: melilotate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+)." [EC:1.14.13.4, RHEA:17672] synonym: "2-hydroxyphenylpropionate hydroxylase activity" EXACT [EC:1.14.13.4] synonym: "2-hydroxyphenylpropionic hydroxylase activity" EXACT [EC:1.14.13.4] synonym: "3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.4] synonym: "melilotate hydroxylase activity" EXACT [] synonym: "melilotic hydroxylase activity" EXACT [EC:1.14.13.4] xref: EC:1.14.13.4 xref: KEGG:R03369 xref: MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN xref: RHEA:17672 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050092 name: meso-tartrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH." [EC:1.3.1.7, RHEA:18556] synonym: "meso-tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.7] xref: EC:1.3.1.7 xref: KEGG:R02544 xref: MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN xref: RHEA:18556 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050093 name: methanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH." [EC:1.1.1.244, RHEA:19404] subset: gosubset_prok synonym: "methanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.244] xref: EC:1.1.1.244 xref: KEGG:R00605 xref: MetaCyc:METHANOL-DEHYDROGENASE-RXN xref: RHEA:19404 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050094 name: methionine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine." [EC:2.6.1.73, RHEA:22887] synonym: "L-methionine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73] synonym: "methionine-glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73] synonym: "MGAT activity" EXACT [EC:2.6.1.73] xref: EC:2.6.1.73 xref: KEGG:R00652 xref: MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN xref: RHEA:22887 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050095 name: methionine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + H(+) = 3-methylthiopropanamine + CO(2)." [EC:4.1.1.57, RHEA:17760] synonym: "L-methionine carboxy-lyase (3-methylthiopropanamine-forming)" EXACT [EC:4.1.1.57] synonym: "L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.57] synonym: "L-methionine decarboxylase activity" EXACT [EC:4.1.1.57] xref: EC:4.1.1.57 xref: KEGG:R00656 xref: MetaCyc:METHIONINE-DECARBOXYLASE-RXN xref: RHEA:17760 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050096 name: methylaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH(4)(+)." [EC:4.3.1.2, RHEA:12832] subset: gosubset_prok synonym: "3-methylaspartase activity" EXACT [EC:4.3.1.2] synonym: "beta-methylaspartase activity" EXACT [EC:4.3.1.2] synonym: "L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)" EXACT [EC:4.3.1.2] synonym: "L-threo-3-methylaspartate ammonia-lyase activity" EXACT [EC:4.3.1.2] xref: EC:4.3.1.2 xref: KEGG:R03696 xref: MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN xref: RHEA:12832 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0050097 name: methylaspartate mutase activity namespace: molecular_function def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate." [EC:5.4.99.1, RHEA:12860] subset: gosubset_prok synonym: "b-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1] synonym: "beta-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1] synonym: "glutamate isomerase activity" EXACT [EC:5.4.99.1] synonym: "glutamate mutase activity" EXACT [EC:5.4.99.1] synonym: "glutamic acid isomerase activity" EXACT [EC:5.4.99.1] synonym: "glutamic acid mutase activity" EXACT [EC:5.4.99.1] synonym: "glutamic isomerase activity" EXACT [EC:5.4.99.1] synonym: "glutamic mutase activity" EXACT [EC:5.4.99.1] synonym: "L-threo-3-methylaspartate carboxy-aminomethylmutase activity" EXACT [EC:5.4.99.1] synonym: "methylaspartic acid mutase activity" EXACT [EC:5.4.99.1] xref: EC:5.4.99.1 xref: KEGG:R00262 xref: MetaCyc:METHYLASPARTATE-MUTASE-RXN xref: RHEA:12860 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0050098 name: methylguanidinase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + methylguanidine = methylammonium + urea." [EC:3.5.3.16, RHEA:11767] synonym: "methylguanidine amidinohydrolase activity" EXACT [EC:3.5.3.16] synonym: "methylguanidine hydrolase activity" EXACT [EC:3.5.3.16] xref: EC:3.5.3.16 xref: KEGG:R01589 xref: MetaCyc:METHYLGUANIDINASE-RXN xref: RHEA:11767 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0050099 name: methylglutamate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-L-glutamate + A + H(2)O = L-glutamate + AH(2) + formaldehyde." [EC:1.5.99.5, RHEA:22575] synonym: "N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.5] synonym: "N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.5] synonym: "N-methylglutamate dehydrogenase activity" EXACT [EC:1.5.99.5] xref: EC:1.5.99.5 xref: KEGG:R00609 xref: MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN xref: RHEA:22575 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0050100 name: methylitaconate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate." [EC:5.3.3.6, RHEA:23483] synonym: "methylitaconate D-isomerase activity" EXACT [] synonym: "methylitaconate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.6] synonym: "methylitaconate isomerase activity" EXACT [EC:5.3.3.6] xref: EC:5.3.3.6 xref: KEGG:R03070 xref: MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN xref: RHEA:23483 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0050101 name: mimosinase activity namespace: molecular_function def: "Catalysis of the reaction: L-mimosine + H(2)O = 3-hydroxy-4H-pyrid-4-one + L-serine." [EC:3.5.1.61, RHEA:13376] synonym: "mimosine amidohydrolase activity" EXACT [EC:3.5.1.61] xref: EC:3.5.1.61 xref: KEGG:R04350 xref: MetaCyc:MIMOSINASE-RXN xref: RHEA:13376 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050102 name: cellodextrin phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN] subset: gosubset_prok synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.49] synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.49] xref: EC:2.4.1.49 xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0050103 name: dextrin dextranase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)." [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN] synonym: "1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.2] synonym: "dextran dextrinase activity" EXACT [EC:2.4.1.2] synonym: "dextrin 6-glucosyltransferase activity" EXACT [EC:2.4.1.2] xref: EC:2.4.1.2 xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050104 name: L-gulonate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH." [EC:1.1.1.45, RHEA:12892] subset: gosubset_prok synonym: "L-3-aldonate dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-3-aldonic dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-3-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-beta-hydroxy-acid-NAD-oxidoreductase activity" EXACT [EC:1.1.1.45] synonym: "L-beta-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-gulonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.45] synonym: "L-gulonic acid dehydrogenase activity" EXACT [EC:1.1.1.45] xref: EC:1.1.1.45 xref: KEGG:R02640 xref: MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN xref: RHEA:12892 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050105 name: L-gulonolactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2." [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN] subset: gosubset_prok synonym: "GLO activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-gamma-lactone oxidase activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-gamma-lactone:O2 oxidoreductase activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-gamma-lactone:oxidoreductase activity" EXACT [EC:1.1.3.8] xref: EC:1.1.3.8 xref: MetaCyc:L-GULONOLACTONE-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050106 name: monomethyl-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + monomethyl sulfate = H(+) + methanol + sulfate." [EC:3.1.6.16, RHEA:14224] synonym: "monomethyl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.16] synonym: "monomethyl-sulphatase activity" EXACT [] xref: EC:3.1.6.16 xref: KEGG:R01145 xref: MetaCyc:MONOMETHYL-SULFATASE-RXN xref: RHEA:14224 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0050107 name: monoterpenol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester." [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:monoterpenol O-acetyltransferase activity" EXACT [EC:2.3.1.69] synonym: "menthol transacetylase activity" NARROW [EC:2.3.1.69] xref: EC:2.3.1.69 xref: MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050108 name: monoterpenyl-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate." [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN] synonym: "bornyl diphosphate hydrolase activity" EXACT [EC:3.1.7.3] synonym: "bornyl pyrophosphate hydrolase activity" EXACT [EC:3.1.7.3] synonym: "monoterpenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.3] synonym: "monoterpenyl-pyrophosphatase activity" EXACT [] xref: EC:3.1.7.3 xref: MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] id: GO:0050109 name: morphine 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+." [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "morphine:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.218] synonym: "naloxone reductase activity" EXACT [EC:1.1.1.218] synonym: "reductase, naloxone" EXACT [EC:1.1.1.218] xref: EC:1.1.1.218 xref: MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050110 name: mucinaminylserine mucinaminidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine." [MetaCyc:3.2.1.110-RXN] synonym: "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity" EXACT [EC:3.2.1.110] synonym: "endo-beta-N-acetyl-D-galactosaminidase activity" BROAD [EC:3.2.1.110] synonym: "endo-beta-N-acetylgalactosaminidase" BROAD [EC:3.2.1.110] xref: EC:3.2.1.97 xref: KEGG:R04527 xref: MetaCyc:3.2.1.110-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0050111 name: mycocerosate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+)." [EC:2.3.1.111, RHEA:10591] synonym: "acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)" EXACT [EC:2.3.1.111] synonym: "mycocerosic acid synthase activity" EXACT [EC:2.3.1.111] xref: EC:2.3.1.111 xref: KEGG:R05189 xref: MetaCyc:MYCOCEROSATE-SYNTHASE-RXN xref: RHEA:10591 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050112 name: inositol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.18, RHEA:16952] subset: gosubset_prok synonym: "inositol:NAD 2-dehydrogenase activity" EXACT [] synonym: "myo-inositol 2-dehydrogenase activity" EXACT [] xref: EC:1.1.1.18 xref: KEGG:R01183 xref: MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN xref: RHEA:16952 is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0050113 name: inositol oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23699] synonym: "meso-inositol oxygenase activity" EXACT [EC:1.13.99.1] synonym: "MOO activity" EXACT [EC:1.13.99.1] synonym: "myo-inositol oxygenase activity" EXACT [] synonym: "myo-inositol:oxygen oxidoreductase activity" EXACT [EC:1.13.99.1] xref: EC:1.13.99.1 xref: KEGG:R01184 xref: MetaCyc:MYO-INOSITOL-OXYGENASE-RXN xref: RHEA:23699 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0050114 name: myo-inosose-2 dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O." [EC:4.2.1.44, RHEA:14068] synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)" EXACT [EC:4.2.1.44] synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity" EXACT [EC:4.2.1.44] synonym: "inosose 2,3-dehydratase activity" EXACT [EC:4.2.1.44] synonym: "ketoinositol dehydratase activity" EXACT [EC:4.2.1.44] xref: EC:4.2.1.44 xref: KEGG:R02782 xref: MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN xref: RHEA:14068 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050115 name: myosin-light-chain-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate." [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN] synonym: "[Myosin light-chain]-phosphatase activity" EXACT [] synonym: "myosin light chain kinase phosphatase activity" EXACT [EC:3.1.3.53] synonym: "myosin light-chain kinase phosphatase activity" RELATED [EC:3.1.3.53] synonym: "myosin-light-chain phosphatase activity" EXACT [EC:3.1.3.53] synonym: "myosin-light-chain-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.53] synonym: "protein phosphatase 2A" RELATED [EC:3.1.3.53] xref: EC:3.1.3.53 xref: MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050116 name: N,N-dimethylformamidase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylformamide + H(2)O = dimethylamine + formate." [EC:3.5.1.56, RHEA:19520] synonym: "dimethylformamidase activity" EXACT [EC:3.5.1.56] synonym: "DMFase activity" EXACT [EC:3.5.1.56] synonym: "N,N-dimethylformamide amidohydrolase activity" EXACT [EC:3.5.1.56] xref: EC:3.5.1.56 xref: KEGG:R02509 xref: MetaCyc:NN-DIMETHYLFORMAMIDASE-RXN xref: RHEA:19520 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050117 name: N-acetyl-beta-alanine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-alanine + H(2)O = beta-alanine + acetate." [EC:3.5.1.21, RHEA:23215] synonym: "N-acetyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.21] xref: EC:3.5.1.21 xref: KEGG:R00909 xref: MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN xref: RHEA:23215 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0050118 name: N-acetyldiaminopimelate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + acetate." [EC:3.5.1.47, RHEA:20408] subset: gosubset_prok synonym: "6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47] synonym: "N-acetyl-L-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.47] synonym: "N-acetyl-LL-diaminopimelate deacylase activity" EXACT [EC:3.5.1.47] synonym: "N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47] xref: EC:3.5.1.47 xref: KEGG:R02733 xref: MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN xref: RHEA:20408 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0050119 name: N-acetylglucosamine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate." [EC:3.5.1.33, RHEA:20596] synonym: "acetylaminodeoxyglucose acetylhydrolase activity" EXACT [EC:3.5.1.33] synonym: "N-acetyl-D-glucosamine amidohydrolase activity" EXACT [EC:3.5.1.33] synonym: "N-acetyl-D-glucosaminyl N-deacetylase activity" EXACT [EC:3.5.1.33] xref: EC:3.5.1.33 xref: KEGG:R01200 xref: MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN xref: RHEA:20596 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0050120 name: N-acetylhexosamine 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + NAD(+) = N-acetyl-D-glucosaminate + 2 H(+) + NADH." [EC:1.1.1.240, RHEA:23147] synonym: "N-acetyl-D-hexosamine dehydrogenase activity" EXACT [EC:1.1.1.240] synonym: "N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.240] synonym: "N-acetylhexosamine dehydrogenase activity" EXACT [EC:1.1.1.240] xref: EC:1.1.1.240 xref: KEGG:R01202 xref: MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN xref: RHEA:23147 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050121 name: N-acylglucosamine 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN] subset: gosubset_prok synonym: "acylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "GlcNAc 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "N-acetylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "N-acyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] xref: EC:5.1.3.8 xref: MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050122 name: N-acylhexosamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + O(2) = N-acetyl-D-glucosaminate + H(2)O(2) + H(+)." [EC:1.1.3.29, RHEA:13032] synonym: "N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29] synonym: "N-acyl-D-hexosamine oxidase activity" EXACT [EC:1.1.3.29] synonym: "N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29] xref: EC:1.1.3.29 xref: KEGG:R01203 xref: MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN xref: RHEA:13032 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050123 name: N-acylmannosamine 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-mannosamine + NAD(+) = N-acyl-D-mannosaminolactone + H(+) + NADH." [EC:1.1.1.233, RHEA:11543] subset: gosubset_prok synonym: "N-acetyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] synonym: "N-acyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] synonym: "N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.233] synonym: "N-acylmannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] xref: EC:1.1.1.233 xref: KEGG:R02651 xref: MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN xref: RHEA:11543 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050124 name: N-acylneuraminate-9-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN] subset: gosubset_prok synonym: "acylneuraminate 9-phosphatase activity" EXACT [EC:3.1.3.29] synonym: "N-acylneuraminate-9-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.29] synonym: "N-acylneuraminic (sialic) acid 9-phosphatase activity" EXACT [EC:3.1.3.29] synonym: "N-acylneuraminic acid 9-phosphate phosphatase activity" EXACT [EC:3.1.3.29] xref: EC:3.1.3.29 xref: MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050125 name: N-benzyloxycarbonylglycine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzyloxycarbonylglycine + H(2)O + H(+) = benzyl alcohol + CO(2) + glycine." [EC:3.5.1.58, RHEA:20903] synonym: "benzyloxycarbonylglycine hydrolase activity" EXACT [EC:3.5.1.58] synonym: "N-benzyloxycarbonylglycine urethanehydrolase activity" EXACT [EC:3.5.1.58] synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity" EXACT [EC:3.5.1.58] synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase I" RELATED [EC:3.5.1.58] synonym: "nalpha-carbobenzoxyamino acid amidohydrolase activity" EXACT [EC:3.5.1.58] xref: EC:3.5.1.58 xref: KEGG:R02551 xref: MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN xref: RHEA:20903 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050126 name: N-carbamoylputrescine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoylputrescine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + putrescine." [EC:3.5.1.53, RHEA:22287] synonym: "carbamoylputrescine hydrolase activity" EXACT [EC:3.5.1.53] synonym: "N-carbamoylputrescine amidohydrolase activity" EXACT [EC:3.5.1.53] synonym: "NCP" RELATED [EC:3.5.1.53] xref: EC:3.5.1.53 xref: KEGG:R01152 xref: MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN xref: RHEA:22287 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050127 name: N-carbamoylsarcosine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoylsarcosine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + sarcosine." [EC:3.5.1.59, RHEA:20060] subset: gosubset_prok synonym: "carbamoylsarcosine amidase activity" EXACT [EC:3.5.1.59] synonym: "CSHase activity" EXACT [EC:3.5.1.59] synonym: "N-carbamoylsarcosine amidohydrolase activity" EXACT [EC:3.5.1.59] xref: EC:3.5.1.59 xref: KEGG:R01563 xref: MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN xref: RHEA:20060 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050128 name: N-feruloylglycine deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-feruloylglycine + H(2)O = ferulate + glycine." [EC:3.5.1.71, RHEA:10487] synonym: "N-feruloylglycine amidohydrolase activity" EXACT [EC:3.5.1.71] synonym: "N-feruloylglycine hydrolase activity" EXACT [EC:3.5.1.71] xref: EC:3.5.1.71 xref: KEGG:R03579 xref: MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN xref: RHEA:10487 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050129 name: N-formylglutamate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-glutamate + H(2)O = L-glutamate + formate." [EC:3.5.1.68, RHEA:12479] subset: gosubset_prok synonym: "beta-citryl-L-glutamate amidase activity" EXACT [EC:3.5.1.68] synonym: "beta-citryl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68] synonym: "beta-citryl-L-glutamate hydrolase activity" EXACT [EC:3.5.1.68] synonym: "beta-citryl-L-glutamate-hydrolyzing enzyme" RELATED [EC:3.5.1.68] synonym: "beta-citrylglutamate amidase activity" EXACT [EC:3.5.1.68] synonym: "formylglutamate deformylase activity" EXACT [EC:3.5.1.68] synonym: "N-formyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68] synonym: "N-formylglutamate hydrolase activity" EXACT [EC:3.5.1.68] xref: EC:3.5.1.68 xref: KEGG:R00525 xref: MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN xref: RHEA:12479 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050130 name: N-methyl-2-oxoglutaramate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H(2)O = 2-oxoglutarate + methylammonium." [EC:3.5.1.36, RHEA:24111] synonym: "5-hydroxy-N-methylpyroglutamate synthase activity" EXACT [EC:3.5.1.36] synonym: "N-methyl-2-oxoglutaramate methylamidohydrolase activity" EXACT [EC:3.5.1.36] xref: EC:3.5.1.36 xref: KEGG:R01587 xref: MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN xref: RHEA:24111 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050131 name: N-methyl-L-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2." [EC:1.5.3.2, MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN] synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.2] synonym: "N-methylamino acid oxidase activity" EXACT [EC:1.5.3.2] xref: EC:1.5.3.2 xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0050132 name: N-methylalanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-L-alanine + H(2)O + NADP(+) = H(+) + methylammonium + NADPH + pyruvate." [EC:1.4.1.17, RHEA:21771] synonym: "N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)" EXACT [EC:1.4.1.17] xref: EC:1.4.1.17 xref: KEGG:R01584 xref: MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN xref: RHEA:21771 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050133 name: N6-hydroxylysine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA." [EC:2.3.1.102, RHEA:22391] synonym: "acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102] synonym: "acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102] synonym: "N(6)-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102] synonym: "N6-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102] synonym: "N6-hydroxylysine:acetyl CoA N6-transacetylase activity" EXACT [EC:2.3.1.102] xref: EC:2.3.1.102 xref: KEGG:R03168 xref: MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN xref: RHEA:22391 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050134 name: N6-methyl-lysine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N(6)-methyl-L-lysine + H(2)O + O(2) = L-lysine + formaldehyde + H(2)O(2)." [EC:1.5.3.4, RHEA:23203] synonym: "6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4] synonym: "epsilon-alkyl-L-lysine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.4] synonym: "epsilon-alkyllysinase activity" EXACT [EC:1.5.3.4] synonym: "epsilon-N-methyllysine demethylase activity" EXACT [EC:1.5.3.4] synonym: "N(6)-methyllysine oxidase activity" EXACT [EC:1.5.3.4] synonym: "N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4] synonym: "N6-methyllysine oxidase activity" EXACT [EC:1.5.3.4] xref: EC:1.5.3.4 xref: KEGG:R00612 xref: MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN xref: RHEA:23203 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0050135 name: NAD(P)+ nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide." [EC:3.2.2.6, MetaCyc:NADP+-NUCLEOSIDASE-RXN] synonym: "NAD(P) nucleosidase activity" EXACT [] synonym: "NAD(P)(+) nucleosidase activity" EXACT [] synonym: "NAD(P)+ glycohydrolase activity" EXACT [EC:3.2.2.6] synonym: "NAD(P)ase activity" EXACT [EC:3.2.2.6] synonym: "nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity" EXACT [EC:3.2.2.6] synonym: "nicotinamide adenine dinucleotide (phosphate) nucleosidase activity" EXACT [EC:3.2.2.6] synonym: "triphosphopyridine nucleotidase activity" EXACT [EC:3.2.2.6] xref: EC:3.2.2.6 xref: MetaCyc:NADP+-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0050136 name: NADH dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.99.5, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN] subset: gosubset_prok synonym: "D-diaphorase activity" EXACT [EC:1.6.99.5] synonym: "DPNH-menadione reductase activity" EXACT [EC:1.6.99.5] synonym: "NADH-quinone oxidoreductase activity" EXACT [EC:1.6.99.5] synonym: "NADH:(quinone-acceptor) oxidoreductase activity" EXACT [EC:1.6.99.5] synonym: "reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity" EXACT [EC:1.6.99.5] xref: EC:1.6.99.5 xref: MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN is_a: GO:0003954 ! NADH dehydrogenase activity is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: GO:0050137 name: NADPH peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O(2) + H(+) + NADPH = 2 H(2)O + NADP(+)." [EC:1.11.1.2, RHEA:15176] synonym: "NADP peroxidase activity" EXACT [EC:1.11.1.2] synonym: "NADPH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.2] synonym: "nicotinamide adenine dinucleotide phosphate peroxidase activity" EXACT [EC:1.11.1.2] synonym: "TPN peroxidase activity" EXACT [EC:1.11.1.2] synonym: "TPNH peroxidase activity" EXACT [EC:1.11.1.2] synonym: "triphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.2] xref: EC:1.11.1.2 xref: KEGG:R00113 xref: MetaCyc:NADPH-PEROXIDASE-RXN xref: RHEA:15176 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0050138 name: nicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH." [EC:1.17.1.5, RHEA:12239] synonym: "nicotinate hydroxylase activity" EXACT [EC:1.17.1.5] synonym: "nicotinate:NADP+ 6-oxidoreductase (hydroxylating)" EXACT [EC:1.17.1.5] synonym: "nicotinic acid hydroxylase activity" EXACT [EC:1.17.1.5] xref: EC:1.17.1.5 xref: KEGG:R01720 xref: MetaCyc:NICOTINATE-DEHYDROGENASE-RXN xref: MetaCyc:RXN-7637 xref: RHEA:12239 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0050139 name: nicotinate glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP." [EC:2.4.1.196, RHEA:19440] synonym: "UDP-glucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] synonym: "UDP-glucose:nicotinic acid-N-glucosyltransferase activity" EXACT [EC:2.4.1.196] synonym: "UDPglucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] synonym: "uridine diphosphoglucose-nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] xref: EC:2.4.1.196 xref: KEGG:R01722 xref: MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN xref: RHEA:19440 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050140 name: nitrate reductase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite." [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN] synonym: "benzyl viologen-nitrate reductase activity" EXACT [EC:1.9.6.1] synonym: "ferrocytochrome:nitrate oxidoreductase activity" EXACT [EC:1.9.6.1] xref: EC:1.9.6.1 xref: MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN is_a: GO:0016677 ! oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor [Term] id: GO:0050141 name: nitroethane oxidase activity namespace: molecular_function def: "Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2." [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN] synonym: "nitroethane reductase activity" EXACT [EC:1.7.3.1] synonym: "nitroethane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1] xref: EC:1.7.3.1 xref: MetaCyc:NITROETHANE-OXIDASE-RXN is_a: GO:0052664 ! nitroalkane oxidase activity [Term] id: GO:0050142 name: nitrogenase (flavodoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate." [EC:1.19.6.1, MetaCyc:NITROGENASE-FLAVODOXIN-RXN] subset: gosubset_prok synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" EXACT [EC:1.19.6.1] xref: EC:1.19.6.1 xref: MetaCyc:NITROGENASE-FLAVODOXIN-RXN is_a: GO:0016738 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor [Term] id: GO:0050143 name: nocardicin-A epimerase activity namespace: molecular_function def: "Catalysis of the reaction: isonocardicin A = nocardicin A." [EC:5.1.1.14, RHEA:22795] synonym: "isonocardicin A epimerase activity" EXACT [EC:5.1.1.14] xref: EC:5.1.1.14 xref: KEGG:R03073 xref: MetaCyc:NOCARDICIN-A-EPIMERASE-RXN xref: RHEA:22795 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0050144 name: nucleoside deoxyribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1." [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN] subset: gosubset_prok synonym: "deoxyribose transferase activity" EXACT [EC:2.4.2.6] synonym: "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)" RELATED [EC:2.4.2.6] synonym: "nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]" RELATED [EC:2.4.2.6] synonym: "nucleoside trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6] synonym: "nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.6] synonym: "purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity" EXACT [EC:2.4.2.6] synonym: "trans-deoxyribosylase activity" EXACT [EC:2.4.2.6] synonym: "trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6] synonym: "trans-N-glycosidase activity" EXACT [EC:2.4.2.6] xref: EC:2.4.2.6 xref: MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0050145 name: nucleoside phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate." [EC:2.7.4.4, MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN] synonym: "ATP:nucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.4] synonym: "NMP-kinase activity" EXACT [EC:2.7.4.4] synonym: "nucleoside monophosphate kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "nucleoside-phosphate kinase activity" EXACT [] xref: EC:2.7.4.4 xref: MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN xref: Reactome:80209 "nucleoside phosphate kinase activity" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: GO:0050146 name: nucleoside phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate." [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN] synonym: "nonspecific nucleoside phosphotransferase activity" EXACT [EC:2.7.1.77] synonym: "nucleotide:2'-nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] synonym: "nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] xref: EC:2.7.1.77 xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: GO:0050147 name: nucleoside ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1." [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN] synonym: "nucleoside N-ribosyltransferase activity" EXACT [EC:2.4.2.5] synonym: "nucleoside:purine(pyrimidine) D-ribosyltransferase activity" EXACT [EC:2.4.2.5] xref: EC:2.4.2.5 xref: MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0050148 name: nucleotide diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate." [EC:2.7.6.4, MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN] synonym: "ATP nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4] synonym: "ATP:nucleoside-5'-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.4] synonym: "ATP:nucleotide pyrophosphotransferase activity" EXACT [EC:2.7.6.4] synonym: "nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4] synonym: "nucleotide pyrophosphokinase activity" EXACT [] xref: EC:2.7.6.4 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0050149 name: o-aminophenol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O." [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN] synonym: "2-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4] synonym: "2-aminophenol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.4] synonym: "GriF" RELATED [EC:1.10.3.4] synonym: "isophenoxazine synthase activity" EXACT [EC:1.10.3.4] synonym: "o-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4] xref: EC:1.10.3.4 xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0050150 name: o-pyrocatechuate decarboxylase activity namespace: molecular_function alt_id: GO:0018790 def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.46, RHEA:21495] synonym: "2,3-DHBA decarboxylase activity" EXACT [EC:4.1.1.46] synonym: "2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.46] synonym: "2,3-dihydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.46] synonym: "2,3-dihydroxybenzoate decarboxylase activity" EXACT [] synonym: "2,3-dihydroxybenzoic acid decarboxylase activity" EXACT [EC:4.1.1.46] xref: EC:4.1.1.46 xref: KEGG:R00821 xref: MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN xref: RHEA:21495 xref: UM-BBD_reactionID:r0579 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050151 name: oleate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-10-hydroxystearate = H(2)O + oleate." [EC:4.2.1.53, RHEA:21855] synonym: "(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)" EXACT [EC:4.2.1.53] synonym: "(R)-10-hydroxystearate 10-hydro-lyase activity" EXACT [EC:4.2.1.53] xref: EC:4.2.1.53 xref: KEGG:R02813 xref: MetaCyc:OLEATE-HYDRATASE-RXN xref: RHEA:21855 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050152 name: omega-amidase activity namespace: molecular_function def: "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN] synonym: "alpha-keto acid-omega-amidase activity" EXACT [EC:3.5.1.3] synonym: "omega-amidodicarboxylate amidohydrolase activity" EXACT [EC:3.5.1.3] synonym: "w-amidase activity" EXACT [] xref: EC:3.5.1.3 xref: MetaCyc:OMEGA-AMIDASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050153 name: omega-hydroxydecanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH." [EC:1.1.1.66, RHEA:20883] synonym: "10-hydroxydecanoate:NAD+ 10-oxidoreductase activity" EXACT [EC:1.1.1.66] synonym: "w-hydroxydecanoate dehydrogenase activity" EXACT [] xref: EC:1.1.1.66 xref: KEGG:R03886 xref: MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN xref: RHEA:20883 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050154 name: opheline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H(+)." [EC:2.7.3.7, RHEA:17556] synonym: "ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity" EXACT [EC:2.7.3.7] xref: EC:2.7.3.7 xref: KEGG:R04388 xref: MetaCyc:OPHELINE-KINASE-RXN xref: RHEA:17556 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0050155 name: ornithine(lysine) transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [EC:2.6.1.68, MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN] synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68] synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68] synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.68] synonym: "ornithine(lysine) aminotransferase activity" EXACT [] xref: EC:2.6.1.68 xref: MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050156 name: ornithine N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H(+)." [EC:2.3.1.127, RHEA:16932] synonym: "benzoyl-CoA:L-ornithine N-benzoyltransferase activity" EXACT [EC:2.3.1.127] synonym: "ornithine N-acyltransferase activity" EXACT [EC:2.3.1.127] xref: EC:2.3.1.127 xref: KEGG:R00664 xref: MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN xref: RHEA:16932 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050157 name: ornithine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = D-ornithine." [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN] subset: gosubset_prok xref: EC:5.1.1.12 xref: MetaCyc:ORNITHINE-RACEMASE-RXN is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0050158 name: orotate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate." [EC:1.3.1.15, RHEA:14864] synonym: "(S)-dihydroorotate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.15] synonym: "dihydro-orotic dehydrogenase activity" EXACT [EC:1.3.1.15] synonym: "L-5,6-dihydro-orotate:NAD oxidoreductase activity" EXACT [EC:1.3.1.15] synonym: "orotate reductase activity" EXACT [EC:1.3.1.15] xref: EC:1.3.1.15 xref: KEGG:R01866 xref: MetaCyc:OROTATE-REDUCTASE-NADPH-RXN xref: RHEA:14864 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050159 name: orsellinate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: o-orsellinate + H(+) = CO(2) + orcinol." [EC:4.1.1.58, RHEA:16736] synonym: "orsellinate carboxy-lyase (orcinol-forming)" EXACT [EC:4.1.1.58] synonym: "orsellinate carboxy-lyase activity" EXACT [EC:4.1.1.58] xref: EC:4.1.1.58 xref: KEGG:R02831 xref: MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN xref: RHEA:16736 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050160 name: orsellinate-depside hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + orsellinate depside = 2 o-orsellinate + H(+)." [EC:3.1.1.40, RHEA:19552] synonym: "lecanorate hydrolase activity" EXACT [EC:3.1.1.40] xref: EC:3.1.1.40 xref: KEGG:R00054 xref: MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN xref: RHEA:19552 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050161 name: oxalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate." [EC:2.8.3.2, RHEA:23591] synonym: "oxalate coenzyme A-transferase activity" EXACT [EC:2.8.3.2] synonym: "succinyl-beta-ketoacyl-CoA transferase activity" EXACT [EC:2.8.3.2] synonym: "succinyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.2] xref: EC:2.8.3.2 xref: KEGG:R01559 xref: MetaCyc:OXALATE-COA-TRANSFERASE-RXN xref: RHEA:23591 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0050162 name: oxalate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H(+) + O(2) + oxalate = 2 CO(2) + H(2)O(2)." [EC:1.2.3.4, RHEA:21881] synonym: "aero-oxalo dehydrogenase activity" EXACT [EC:1.2.3.4] synonym: "oxalate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.4] synonym: "oxalic acid oxidase activity" EXACT [EC:1.2.3.4] xref: EC:1.2.3.4 xref: KEGG:R00273 xref: MetaCyc:OXALATE-OXIDASE-RXN xref: RHEA:21881 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0050163 name: oxaloacetate tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate = enol-oxaloacetate." [EC:5.3.2.2, RHEA:16024] synonym: "oxalacetic keto-enol isomerase activity" EXACT [EC:5.3.2.2] synonym: "oxaloacetate keto-enol tautomerase activity" EXACT [EC:5.3.2.2] synonym: "oxaloacetate keto-enol-isomerase activity" EXACT [EC:5.3.2.2] xref: EC:5.3.2.2 xref: KEGG:R00363 xref: MetaCyc:OXALOACETATE-TAUTOMERASE-RXN xref: RHEA:16024 is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0050164 name: oxoglutarate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP(+) = CO(2) + NADPH + succinyl-CoA." [EC:1.2.1.52, RHEA:21403] synonym: "2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.1.52] xref: EC:1.2.1.52 xref: KEGG:R00265 xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN xref: RHEA:21403 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050165 name: pantetheine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN] synonym: "ATP:pantetheine 4'-phosphotransferase activity" EXACT [EC:2.7.1.34] synonym: "pantetheine kinase (phosphorylating)" EXACT [EC:2.7.1.34] xref: EC:2.7.1.34 xref: MetaCyc:PANTETHEINE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050166 name: pantoate 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH." [EC:1.1.1.106, RHEA:23003] synonym: "(R)-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106] synonym: "D-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106] synonym: "panthothenase activity" EXACT [EC:1.1.1.106] synonym: "pantoate dehydrogenase activity" EXACT [EC:1.1.1.106] xref: EC:1.1.1.106 xref: KEGG:R02471 xref: MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN xref: RHEA:23003 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050167 name: pantothenoylcysteine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H(+) = (R)-pantetheine + CO(2)." [EC:4.1.1.30, RHEA:15080] synonym: "N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30] synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)" EXACT [EC:4.1.1.30] synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30] synonym: "pantothenylcysteine decarboxylase activity" EXACT [EC:4.1.1.30] xref: EC:4.1.1.30 xref: KEGG:R02972 xref: MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN xref: RHEA:15080 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050168 name: pentanamidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + pentanamide = NH(4)(+) + valerate." [EC:3.5.1.50, RHEA:10003] synonym: "pentanamide amidohydrolase activity" EXACT [EC:3.5.1.50] synonym: "valeramidase activity" EXACT [EC:3.5.1.50] xref: EC:3.5.1.50 xref: KEGG:R02938 xref: MetaCyc:PENTANAMIDASE-RXN xref: RHEA:10003 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050169 name: peptide-tryptophan 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine." [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN] synonym: "peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.26] synonym: "peptidyltryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.26] synonym: "pyrrolooxygenase activity" EXACT [EC:1.13.11.26] synonym: "tryptophan pyrrolooxygenase activity" EXACT [EC:1.13.11.26] xref: EC:1.13.11.26 xref: MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050170 name: peptidyl-glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3." [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN] synonym: "peptideglutaminase activity" EXACT [EC:3.5.1.43] synonym: "peptidoglutaminase activity" EXACT [EC:3.5.1.43] synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43] synonym: "peptidyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.43] xref: EC:3.5.1.43 xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050171 name: phenol beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside." [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "phenol b-glucosyltransferase activity" EXACT [] synonym: "phenol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDP glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDP-glucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDPglucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDPglucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.35] xref: EC:2.4.1.35 xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050172 name: phenylalanine 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + O(2) = 2-phenylacetamide + CO(2) + H(2)O." [EC:1.13.12.9, RHEA:10715] subset: gosubset_prok synonym: "L-phenylalanine oxidase (deaminating and decarboxylating)" EXACT [EC:1.13.12.9] synonym: "l-phenylalanine oxidase (deaminating and decarboxylating) activity" EXACT [EC:1.13.12.9] synonym: "L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.9] synonym: "phenylalanine (deaminating, decarboxylating) oxidase activity" EXACT [EC:1.13.12.9] synonym: "phenylalanine (deaminating, decarboxylating)oxidase activity" EXACT [EC:1.13.12.9] xref: EC:1.13.12.9 xref: KEGG:R00690 xref: MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN xref: RHEA:10715 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050173 name: phenylalanine adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + ATP = N-adenylyl-L-phenylalanine + diphosphate + 2 H(+)." [EC:2.7.7.54, RHEA:17192] synonym: "ATP:L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54] synonym: "ATP:phenylalanine adenylyltransferase activity" EXACT [] synonym: "L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54] xref: EC:2.7.7.54 xref: KEGG:R00687 xref: MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN xref: RHEA:17192 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0050174 name: phenylalanine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN] synonym: "aromatic L-amino acid decarboxylase activity" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine carboxy-lyase activity" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine decarboxylase activity" EXACT [EC:4.1.1.53] xref: EC:4.1.1.53 xref: MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050175 name: phenylalanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH." [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "L-phenylalanine dehydrogenase activity" EXACT [EC:1.4.1.20] synonym: "L-phenylalanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.20] synonym: "PHD" RELATED [EC:1.4.1.20] synonym: "PheDH activity" EXACT [EC:1.4.1.20] xref: EC:1.4.1.20 xref: MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050176 name: phenylalanine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H(+)." [EC:2.3.1.53, RHEA:17804] synonym: "acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.53] synonym: "acetyl-CoA:L-phenylalanine N-acetyltransferase activity" EXACT [EC:2.3.1.53] xref: EC:2.3.1.53 xref: KEGG:R00693 xref: MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN xref: RHEA:17804 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0050177 name: phenylpyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2." [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN] synonym: "phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)" EXACT [EC:4.1.1.43] synonym: "phenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.43] xref: EC:4.1.1.43 xref: MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050178 name: phenylpyruvate tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [EC:5.3.2.1, MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN] subset: gosubset_prok synonym: "phenylpyruvate keto--enol tautomerase activity" EXACT [EC:5.3.2.1] synonym: "phenylpyruvate keto-enol-isomerase activity" EXACT [EC:5.3.2.1] synonym: "phenylpyruvic keto--enol isomerase activity" EXACT [EC:5.3.2.1] xref: EC:5.3.2.1 xref: MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0050179 name: phenylserine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine." [EC:4.1.2.26, RHEA:21715] synonym: "L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.26] synonym: "L-threo-3-phenylserine benzaldehyde-lyase activity" EXACT [EC:4.1.2.26] xref: EC:4.1.2.26 xref: KEGG:R01766 xref: MetaCyc:PHENYLSERINE-ALDOLASE-RXN xref: RHEA:21715 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050180 name: phloretin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phloretin = H(+) + phloretate + phloroglucinol." [EC:3.7.1.4, RHEA:23399] synonym: "2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity" EXACT [EC:3.7.1.4] synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.7.1.4] xref: EC:3.7.1.4 xref: KEGG:R02901 xref: MetaCyc:PHLORETIN-HYDROLASE-RXN xref: RHEA:23399 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0050181 name: phorbol-diester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate." [EC:3.1.1.51, RHEA:21319] synonym: "12,13-diacylphorbate 12-acylhydrolase activity" EXACT [EC:3.1.1.51] synonym: "diacylphorbate 12-hydrolase activity" EXACT [EC:3.1.1.51] synonym: "PDEH" RELATED [EC:3.1.1.51] synonym: "phorbol-12,13-diester 12-ester hydrolase activity" EXACT [EC:3.1.1.51] xref: EC:3.1.1.51 xref: KEGG:R04119 xref: MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN xref: RHEA:21319 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050182 name: phosphate butyryltransferase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA." [EC:2.3.1.19, RHEA:20895] subset: gosubset_prok synonym: "butanoyl-CoA:phosphate butanoyltransferase activity" EXACT [EC:2.3.1.19] synonym: "phosphotransbutyrylase activity" EXACT [EC:2.3.1.19] xref: EC:2.3.1.19 xref: KEGG:R01174 xref: MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN xref: RHEA:20895 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050183 name: phosphatidylcholine 12-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O(2) = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H(2)O + NAD(+)." [EC:1.14.13.26, RHEA:11371] synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.26] synonym: "oleate D12-hydroxylase activity" EXACT [] synonym: "oleate Delta(12)-hydroxylase activity" EXACT [EC:1.14.13.26] synonym: "oleate delta12-hydroxylase activity" EXACT [EC:1.14.13.26] synonym: "oleate delta12-monooxygenase activity" EXACT [EC:1.14.13.26] synonym: "ricinoleic acid synthase activity" EXACT [EC:1.14.13.26] xref: EC:1.14.13.26 xref: KEGG:R03476 xref: MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN xref: RHEA:11371 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050184 name: phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + H(+) + NADH." [EC:1.3.1.35, RHEA:12567] synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity" EXACT [EC:1.3.1.35] synonym: "linoleate synthase activity" EXACT [EC:1.3.1.35] synonym: "oleate desaturase activity" EXACT [EC:1.3.1.35] synonym: "oleoyl-CoA desaturase activity" EXACT [EC:1.3.1.35] synonym: "oleoylphosphatidylcholine desaturase activity" EXACT [EC:1.3.1.35] xref: EC:1.3.1.35 xref: KEGG:R03475 xref: MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN xref: RHEA:12567 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050185 name: phosphatidylinositol deacylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H(2)O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H(+)." [EC:3.1.1.52, RHEA:18004] synonym: "1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity" EXACT [EC:3.1.1.52] synonym: "phosphatidylinositol phospholipase A2 activity" EXACT [EC:3.1.1.52] xref: EC:3.1.1.52 xref: KEGG:R03360 xref: MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN xref: RHEA:18004 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050186 name: phosphoadenylylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate." [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN] synonym: "3'-phosphoadenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.2] synonym: "3-phosphoadenosine 5-phosphosulfate sulfatase activity" EXACT [EC:3.6.2.2] synonym: "3-phosphoadenylyl sulfatase activity" EXACT [EC:3.6.2.2] synonym: "PAPS sulfatase activity" EXACT [EC:3.6.2.2] synonym: "phosphoadenylylsulphatase activity" EXACT [] xref: EC:3.6.2.2 xref: MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides [Term] id: GO:0050187 name: phosphoamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-phosphocreatine + H(2)O = creatine + phosphate." [EC:3.9.1.1, RHEA:12980] synonym: "creatine phosphatase activity" EXACT [EC:3.9.1.1] synonym: "phosphamide hydrolase activity" EXACT [EC:3.9.1.1] xref: EC:3.9.1.1 xref: KEGG:R01882 xref: MetaCyc:PHOSPHOAMIDASE-RXN xref: RHEA:12980 is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds [Term] id: GO:0050188 name: phosphoenolpyruvate mutase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate." [EC:5.4.2.9, RHEA:17016] subset: gosubset_prok synonym: "PEP mutase activity" EXACT [EC:5.4.2.9] synonym: "PEP phosphomutase activity" EXACT [EC:5.4.2.9] synonym: "PEPPM" RELATED [EC:5.4.2.9] synonym: "phosphoenolpyruvate 2,3-phosphonomutase activity" EXACT [EC:5.4.2.9] synonym: "phosphoenolpyruvate phosphomutase activity" EXACT [EC:5.4.2.9] synonym: "phosphoenolpyruvate-phosphonopyruvate phosphomutase activity" EXACT [EC:5.4.2.9] xref: EC:5.4.2.9 xref: KEGG:R00661 xref: MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN xref: RHEA:17016 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0050189 name: phosphoenolpyruvate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phosphoenolpyruvate = phosphate + pyruvate." [EC:3.1.3.60, RHEA:20000] synonym: "PEP phosphatase activity" EXACT [EC:3.1.3.60] synonym: "phosphoenolpyruvate phosphohydrolase activity" EXACT [EC:3.1.3.60] xref: EC:3.1.3.60 xref: KEGG:R00208 xref: MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN xref: RHEA:20000 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050190 name: phosphoglucokinase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.10, RHEA:13380] synonym: "ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10] synonym: "ATP:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10] synonym: "glucose-phosphate kinase activity" EXACT [EC:2.7.1.10] synonym: "phosphoglucokinase (phosphorylating)" EXACT [EC:2.7.1.10] xref: EC:2.7.1.10 xref: KEGG:R00949 xref: MetaCyc:PHOSPHOGLUCOKINASE-RXN xref: RHEA:13380 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050191 name: phosphoglycerate kinase (GTP) activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H(+)." [EC:2.7.2.10, RHEA:23335] synonym: "GTP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.10] xref: EC:2.7.2.10 xref: KEGG:R01517 xref: MetaCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN xref: RHEA:23335 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0050192 name: phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate + H(2)O = D-glycerate + phosphate." [EC:3.1.3.20, RHEA:21159] synonym: "D-2-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.20] synonym: "D-glycerate-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.20] synonym: "glycerophosphate phosphatase activity" EXACT [EC:3.1.3.20] xref: EC:3.1.3.20 xref: KEGG:R01748 xref: MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:21159 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050193 name: phosphoketolase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O." [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN] subset: gosubset_prok synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.9] synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.9] synonym: "xylulose-5-phosphate phosphoketolase activity" EXACT [EC:4.1.2.9] xref: EC:4.1.2.9 xref: MetaCyc:PHOSPHOKETOLASE-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050194 name: phosphonoacetaldehyde hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate." [EC:3.11.1.1, RHEA:18908] subset: gosubset_prok synonym: "2-oxoethylphosphonate phosphonohydrolase activity" EXACT [EC:3.11.1.1] synonym: "2-phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1] synonym: "phosphonatase activity" EXACT [EC:3.11.1.1] synonym: "phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1] xref: EC:3.11.1.1 xref: KEGG:R00747 xref: MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN xref: RHEA:18908 is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds [Term] id: GO:0050195 name: phosphoribokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H(+)." [EC:2.7.1.18, RHEA:21219] synonym: "ATP:D-ribose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.18] synonym: "phosphoribokinase (phosphorylating)" EXACT [EC:2.7.1.18] xref: EC:2.7.1.18 xref: KEGG:R01050 xref: MetaCyc:PHOSPHORIBOKINASE-RXN xref: RHEA:21219 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050196 name: [phosphorylase] phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate." [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN] synonym: "glycogen phosphorylase phosphatase activity" EXACT [EC:3.1.3.17] synonym: "phosphorylase a phosphatase activity" EXACT [EC:3.1.3.17] synonym: "phosphorylase a phosphohydrolase activity" EXACT [EC:3.1.3.17] synonym: "phosphorylase phosphatase activity" EXACT [] synonym: "PR-enzyme" RELATED [EC:3.1.3.17] synonym: "protein phosphatase C" RELATED [EC:3.1.3.17] synonym: "type 1 protein phosphatase activity" EXACT [EC:3.1.3.17] xref: EC:3.1.3.17 xref: MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050197 name: phytanate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA." [EC:6.2.1.24, RHEA:21383] subset: gosubset_prok synonym: "phytanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.24] synonym: "phytanoyl-CoA ligase activity" EXACT [EC:6.2.1.24] xref: EC:6.2.1.24 xref: KEGG:R03631 xref: MetaCyc:PHYTANATE--COA-LIGASE-RXN xref: Reactome:80313 "phytanate-CoA ligase activity" xref: RHEA:21383 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050198 name: pinosylvin synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO(2) + 4 CoA + pinosylvin." [EC:2.3.1.146, RHEA:12555] synonym: "malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.146] synonym: "pine stilbene synthase activity" EXACT [EC:2.3.1.146] synonym: "stilbene synthase activity" BROAD [EC:2.3.1.146] xref: EC:2.3.1.146 xref: KEGG:R02505 xref: MetaCyc:PINOSYLVIN-SYNTHASE-RXN xref: RHEA:12555 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050199 name: piperidine N-piperoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H(+)." [EC:2.3.1.145, RHEA:14564] synonym: "(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145] synonym: "piperidine piperoyltransferase activity" EXACT [EC:2.3.1.145] synonym: "piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145] xref: EC:2.3.1.145 xref: KEGG:R03994 xref: MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN xref: RHEA:14564 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050200 name: plasmalogen synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine." [EC:2.3.1.25, MetaCyc:PLASMALOGEN-SYNTHASE-RXN] synonym: "1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.25] synonym: "acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity" EXACT [EC:2.3.1.25] synonym: "lysoplasmenylcholine acyltransferase activity" EXACT [EC:2.3.1.25] synonym: "O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.25] xref: EC:2.3.1.25 xref: MetaCyc:PLASMALOGEN-SYNTHASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050201 name: fucokinase activity namespace: molecular_function def: "Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.52, RHEA:13244] synonym: "ATP:6-deoxy-L-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.52] synonym: "ATP:beta-L-fucose 1-phosphotransferase activity" EXACT [EC:2.7.1.52] synonym: "fucokinase (phosphorylating) activity" EXACT [EC:2.7.1.52] synonym: "fucose kinase activity" EXACT [EC:2.7.1.52] synonym: "L-fucokinase activity" EXACT [EC:2.7.1.52] synonym: "L-fucose kinase activity" EXACT [EC:2.7.1.52] xref: EC:2.7.1.52 xref: KEGG:R03161 xref: MetaCyc:FUCOKINASE-RXN xref: RHEA:13244 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050202 name: octopamine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH(4)(+)." [EC:4.2.1.87, RHEA:18176] synonym: "octopamine hydro-lyase (deaminating)" EXACT [EC:4.2.1.87] synonym: "octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]" RELATED [EC:4.2.1.87] synonym: "octopamine hydrolyase activity" EXACT [EC:4.2.1.87] xref: EC:4.2.1.87 xref: KEGG:R03358 xref: MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN xref: RHEA:18176 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050203 name: oxalate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA." [EC:6.2.1.8, RHEA:18296] synonym: "oxalate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.8] synonym: "oxalyl coenzyme A synthetase activity" EXACT [EC:6.2.1.8] synonym: "oxalyl-CoA synthetase activity" EXACT [EC:6.2.1.8] xref: EC:6.2.1.8 xref: KEGG:R01558 xref: MetaCyc:OXALATE--COA-LIGASE-RXN xref: RHEA:18296 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050204 name: oxalomalate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate." [EC:4.1.3.13, RHEA:22035] synonym: "3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)" EXACT [EC:4.1.3.13] synonym: "3-oxalomalate glyoxylate-lyase activity" EXACT [EC:4.1.3.13] xref: EC:4.1.3.13 xref: KEGG:R00477 xref: MetaCyc:OXALOMALATE-LYASE-RXN xref: RHEA:22035 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0050205 name: oxamate carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate." [EC:2.1.3.5, RHEA:22987] synonym: "carbamoyl-phosphate:oxamate carbamoyltransferase activity" EXACT [EC:2.1.3.5] synonym: "oxamic transcarbamylase activity" EXACT [EC:2.1.3.5] xref: EC:2.1.3.5 xref: KEGG:R02937 xref: MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN xref: RHEA:22987 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0050206 name: oximinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate." [EC:2.6.3.1, RHEA:11627] synonym: "oximase activity" EXACT [EC:2.6.3.1] synonym: "pyruvate-acetone oximinotransferase activity" EXACT [EC:2.6.3.1] synonym: "pyruvate-oxime:acetone oximinotransferase activity" EXACT [EC:2.6.3.1] synonym: "transoximase activity" EXACT [EC:2.6.3.1] synonym: "transoximinase activity" EXACT [EC:2.6.3.1] xref: EC:2.6.3.1 xref: KEGG:R03796 xref: MetaCyc:OXIMINOTRANSFERASE-RXN xref: RHEA:11627 is_a: GO:0016770 ! oximinotransaminase activity [Term] id: GO:0050207 name: plasmanylethanolamine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O." [EC:1.14.99.19, MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN] synonym: "1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19] synonym: "1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19] synonym: "alkylacylglycero-phosphorylethanolamine dehydrogenase activity" EXACT [EC:1.14.99.19] synonym: "alkylacylglycerophosphoethanolamine desaturase activity" EXACT [EC:1.14.99.19] synonym: "dehydrogenase, alkyl-acylglycerophosphorylethanolamine" EXACT [EC:1.14.99.19] synonym: "O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.19] synonym: "plasmenylethanolamine desaturase activity" EXACT [] xref: EC:1.14.99.19 xref: MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050208 name: polysialic-acid O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [EC:2.3.1.136] synonym: "lecithin retinol acyl transferase activity" EXACT [EC:2.3.1.136] synonym: "lecithin:retinol acyltransferase activity" EXACT [EC:2.3.1.136] synonym: "LRAT" RELATED [EC:2.3.1.136] synonym: "retinyl ester synthase activity" EXACT [EC:2.3.1.136] xref: EC:2.3.1.136 xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050209 name: polyvinyl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2." [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN] synonym: "dehydrogenase, polyvinyl alcohol" EXACT [EC:1.1.3.30] synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.30] synonym: "PVA oxidase activity" EXACT [EC:1.1.3.30] xref: EC:1.1.3.30 xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050210 name: prenyl-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate." [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN] synonym: "prenol pyrophosphatase activity" EXACT [EC:3.1.7.1] synonym: "prenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.1] synonym: "prenyl-pyrophosphatase activity" EXACT [] synonym: "prenylphosphatase activity" EXACT [EC:3.1.7.1] xref: EC:3.1.7.1 xref: MetaCyc:PRENYL-PYROPHOSPHATASE-RXN is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] id: GO:0050211 name: procollagen galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN] synonym: "collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "collagen hydroxylysyl galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "hydroxylysine galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDP galactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "uridine diphosphogalactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] xref: EC:2.4.1.50 xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0050212 name: progesterone 11-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + progesterone = 11alpha-hydroxyprogesterone + A + H(2)O." [EC:1.14.99.14, RHEA:18208] synonym: "progesterone 11-alpha-hydroxylase activity" EXACT [EC:1.14.99.14] synonym: "progesterone 11a-monooxygenase activity" EXACT [] synonym: "progesterone 11alpha-hydroxylase activity" EXACT [EC:1.14.99.14] synonym: "progesterone 11alpha-monooxygenase activity" EXACT [EC:1.14.99.14] synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)" EXACT [EC:1.14.99.14] xref: EC:1.14.99.14 xref: KEGG:R02214 xref: MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN xref: RHEA:18208 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050213 name: progesterone 5-alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH." [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN] synonym: "5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.30] synonym: "delta4-steroid 5alpha-reductase (progesterone)" EXACT [EC:1.3.1.30] synonym: "progesterone 5a-reductase activity" EXACT [] synonym: "progesterone 5alpha-reductase activity" EXACT [EC:1.3.1.30] synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.1.30] xref: EC:1.3.1.30 xref: MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050214 name: progesterone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + progesterone = A + H(2)O + testosterone acetate." [EC:1.14.99.4, RHEA:11987] synonym: "progesterone hydroxylase activity" EXACT [EC:1.14.99.4] synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.4] xref: EC:1.14.99.4 xref: KEGG:R02212 xref: MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN xref: RHEA:11987 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050215 name: propanediol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,2-diol = H(2)O + propanal." [EC:4.2.1.28, RHEA:14572] subset: gosubset_prok synonym: "1,2-propanediol dehydratase activity" EXACT [EC:4.2.1.28] synonym: "adenosylcobalamin-dependent diol dehydratase activity" EXACT [EC:4.2.1.28] synonym: "coenzyme B12-dependent diol dehydrase activity" EXACT [EC:4.2.1.28] synonym: "diol dehydrase activity" EXACT [EC:4.2.1.28] synonym: "diol dehydratase activity" EXACT [EC:4.2.1.28] synonym: "dioldehydratase activity" EXACT [EC:4.2.1.28] synonym: "DL-1,2-propanediol hydro-lyase activity" EXACT [EC:4.2.1.28] synonym: "meso-2,3-butanediol dehydrase activity" EXACT [EC:4.2.1.28] synonym: "propane-1,2-diol hydro-lyase (propanal-forming)" EXACT [EC:4.2.1.28] synonym: "propane-1,2-diol hydro-lyase activity" EXACT [EC:4.2.1.28] synonym: "propanediol dehydrase activity" EXACT [EC:4.2.1.28] xref: EC:4.2.1.28 xref: KEGG:R02376 xref: MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN xref: RHEA:14572 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050216 name: propanediol-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH." [EC:1.1.1.7, RHEA:21587] xref: EC:1.1.1.7 xref: KEGG:R04236 xref: MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN xref: RHEA:21587 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050217 name: propioin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal." [EC:4.1.2.35, RHEA:11103] synonym: "4-hydroxy-3-hexanone aldolase activity" EXACT [EC:4.1.2.35] synonym: "4-hydroxy-3-hexanone propanal-lyase (propanal-forming)" EXACT [EC:4.1.2.35] synonym: "4-hydroxy-3-hexanone propanal-lyase activity" EXACT [EC:4.1.2.35] xref: EC:4.1.2.35 xref: KEGG:R00038 xref: MetaCyc:PROPIOIN-SYNTHASE-RXN xref: RHEA:11103 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050218 name: propionate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN] subset: gosubset_prok synonym: "propanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.17] synonym: "propionyl-CoA synthetase activity" EXACT [EC:6.2.1.17] xref: EC:6.2.1.17 xref: MetaCyc:PROPIONATE--COA-LIGASE-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050219 name: prostaglandin-A1 delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin A1 = prostaglandin C1." [EC:5.3.3.9, RHEA:10463] synonym: "(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity" EXACT [EC:5.3.3.9] synonym: "prostaglandin A isomerase activity" EXACT [EC:5.3.3.9] synonym: "prostaglandin-A1 D-isomerase activity" EXACT [] xref: EC:5.3.3.9 xref: KEGG:R04565 xref: MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN xref: RHEA:10463 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0050220 name: prostaglandin-E synthase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12896] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [EC:5.3.99.3] synonym: "endoperoxide isomerase activity" EXACT [EC:5.3.99.3] synonym: "PGE isomerase activity" EXACT [EC:5.3.99.3] synonym: "PGE2 isomerase activity" EXACT [EC:5.3.99.3] synonym: "PGH-PGE isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin endoperoxide E isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin endoperoxide E2 isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin H-E isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin R-prostaglandin E isomerase activity" EXACT [EC:5.3.99.3] synonym: "Prostaglandin-H(2) E-isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin-H2 E-isomerase activity" EXACT [EC:5.3.99.3] xref: EC:5.3.99.3 xref: KEGG:R02265 xref: MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN xref: Reactome:80371 "prostaglandin-E synthase activity" xref: RHEA:12896 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0050221 name: prostaglandin-E2 9-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN] synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity" EXACT [EC:1.1.1.189] synonym: "9-keto-prostaglandin E(2) reductase activity" EXACT [EC:1.1.1.189] synonym: "9-keto-prostaglandin E2 reductase activity" EXACT [EC:1.1.1.189] synonym: "9-ketoprostaglandin reductase activity" EXACT [EC:1.1.1.189] synonym: "PGE(2) 9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE-9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2 9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2-9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2-9-OR" RELATED [EC:1.1.1.189] synonym: "prostaglandin E 9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "prostaglandin E2-9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "prostaglandin-E(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "prostaglandin-E2 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "reductase, 15-hydroxy-9-oxoprostaglandin" EXACT [EC:1.1.1.189] xref: EC:1.1.1.189 xref: MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050223 name: protocatechuate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.63, RHEA:22419] synonym: "3,4-dihydrobenzoate decarboxylase activity" EXACT [EC:4.1.1.63] synonym: "3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.63] synonym: "3,4-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.63] synonym: "protocatechuate carboxy-lyase activity" EXACT [EC:4.1.1.63] xref: EC:4.1.1.63 xref: KEGG:R00822 xref: MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN xref: RHEA:22419 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050224 name: prunasin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-prunasin + H(2)O = D-glucose + mandelonitrile." [EC:3.2.1.118, RHEA:16492] synonym: "prunasin b-glucosidase activity" EXACT [] synonym: "prunasin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.118] synonym: "prunasin hydrolase activity" EXACT [EC:3.2.1.118] xref: EC:3.2.1.118 xref: KEGG:R02558 xref: MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN xref: RHEA:16492 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050225 name: pseudouridine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H(+) + pseudouridine 5'-phosphate." [EC:2.7.1.83, RHEA:22451] synonym: "ATP:pseudouridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.83] synonym: "pseudouridine kinase (phosphorylating)" EXACT [EC:2.7.1.83] xref: EC:2.7.1.83 xref: KEGG:R03315 xref: MetaCyc:PSEUDOURIDINE-KINASE-RXN xref: RHEA:22451 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050226 name: psychosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate." [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity" EXACT [EC:2.8.2.13] synonym: "3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity" EXACT [EC:2.8.2.13] synonym: "PAPS:psychosine sulphotransferase activity" EXACT [EC:2.8.2.13] synonym: "psychosine sulphotransferase activity" EXACT [] xref: EC:2.8.2.13 xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050227 name: pteridine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown." [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN] synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.17.3.1] xref: EC:1.17.3.1 xref: MetaCyc:PTERIDINE-OXIDASE-RXN is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: GO:0050228 name: pterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3." [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN] synonym: "2-amino-4-hydroxypteridine aminohydrolase activity" EXACT [EC:3.5.4.11] synonym: "acrasinase activity" EXACT [EC:3.5.4.11] xref: EC:3.5.4.11 xref: MetaCyc:PTERIN-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050229 name: pterocarpin synthase activity namespace: molecular_function def: "Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH." [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN] synonym: "medicarpin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.246] synonym: "pterocarpan synthase activity" EXACT [EC:1.1.1.246] xref: EC:1.1.1.246 xref: MetaCyc:PTEROCARPIN-SYNTHASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050230 name: purine imidazole-ring cyclase activity namespace: molecular_function def: "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O." [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN] synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)" EXACT [EC:4.3.2.4] synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4] synonym: "DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4] xref: EC:4.3.2.4 xref: MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN is_a: GO:0009975 ! cyclase activity is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0050231 name: putrescine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H(+) + phosphate." [EC:2.1.3.6, RHEA:21939] subset: gosubset_prok synonym: "carbamoyl-phosphate:putrescine carbamoyltransferase activity" EXACT [EC:2.1.3.6] synonym: "PTCase activity" EXACT [EC:2.1.3.6] synonym: "putrescine synthase activity" EXACT [EC:2.1.3.6] synonym: "putrescine transcarbamylase activity" EXACT [EC:2.1.3.6] xref: EC:2.1.3.6 xref: KEGG:R01399 xref: MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN xref: RHEA:21939 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0050232 name: putrescine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN] subset: gosubset_prok synonym: "putrescine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.10] xref: EC:1.4.3.10 xref: MetaCyc:PUTRESCINE-OXIDASE-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0050233 name: pyranose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + O(2) = 2-dehydro-D-glucose + H(2)O(2)." [EC:1.1.3.10, RHEA:10555] synonym: "glucose 2-oxidase activity" EXACT [EC:1.1.3.10] synonym: "pyranose-2-oxidase activity" EXACT [EC:1.1.3.10] synonym: "pyranose:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.10] xref: EC:1.1.3.10 xref: KEGG:R00302 xref: MetaCyc:PYRANOSE-OXIDASE-RXN xref: RHEA:10555 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050234 name: pyrazolylalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H(2)O." [EC:4.2.1.50, RHEA:24515] synonym: "beta-pyrazolylalaninase activity" EXACT [EC:4.2.1.50] synonym: "L-serine hydro-lyase (adding pyrazole)" EXACT [EC:4.2.1.50] synonym: "L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]" RELATED [EC:4.2.1.50] xref: EC:4.2.1.50 xref: KEGG:R02378 xref: MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN xref: RHEA:24515 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050235 name: pyridoxal 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH." [EC:1.1.1.107, RHEA:21339] synonym: "pyridoxal dehydrogenase activity" EXACT [EC:1.1.1.107] synonym: "pyridoxal:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.107] xref: EC:1.1.1.107 xref: KEGG:R01707 xref: MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN xref: RHEA:21339 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050236 name: pyridoxine:NADP 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal." [EC:1.1.1.65, RHEA:16132] synonym: "PL reductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxal reductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxin dehydrogenase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxine dehydrogenase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxine:NADP 4-oxidoreductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxol dehydrogenase activity" EXACT [EC:1.1.1.65] xref: EC:1.1.1.65 xref: KEGG:R01708 xref: MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN xref: RHEA:16132 is_a: GO:0004033 ! aldo-keto reductase (NADP) activity [Term] id: GO:0050237 name: pyridoxine 4-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2." [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN] synonym: "pyridoxin 4-oxidase activity" EXACT [EC:1.1.3.12] synonym: "pyridoxine:oxygen 4-oxidoreductase activity" EXACT [EC:1.1.3.12] synonym: "pyridoxol 4-oxidase activity" EXACT [EC:1.1.3.12] xref: EC:1.1.3.12 xref: MetaCyc:PYRIDOXINE-4-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050238 name: pyridoxine 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor." [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN] synonym: "pyridoxal-5-dehydrogenase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxin 5-dehydrogenase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxine 5'-dehydrogenase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxine:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxine:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxol 5-dehydrogenase activity" EXACT [EC:1.1.99.9] xref: EC:1.1.99.9 xref: MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0050239 name: pyrithiamine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3." [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN] synonym: "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity" EXACT [EC:3.5.4.20] xref: EC:3.5.4.20 xref: MetaCyc:PYRITHIAMIN-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050240 name: pyrogallol 1,2-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+)." [EC:1.13.11.35, RHEA:19676] synonym: "1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.35] synonym: "pyrogallol 1,2-dioxygenase activity" EXACT [EC:1.13.11.35] xref: EC:1.13.11.35 xref: KEGG:R03246 xref: MetaCyc:PYROGALLOL-12-OXYGENASE-RXN xref: RHEA:19676 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050241 name: pyrroline-2-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN] synonym: "delta1-pyrroline-2-carboxylate reductase activity" EXACT [EC:1.5.1.1] synonym: "L-proline:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.5.1.1] xref: EC:1.5.1.1 xref: MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050242 name: pyruvate, phosphate dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H(+) + phosphoenolpyruvate." [EC:2.7.9.1, RHEA:10759] subset: gosubset_prok synonym: "ATP:pyruvate, phosphate phosphotransferase activity" EXACT [EC:2.7.9.1] synonym: "orthophosphate dikinase pyruvate" RELATED [EC:2.7.9.1] synonym: "PPDK" RELATED [EC:2.7.9.1] synonym: "pyruvate, Pi dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate,orthophosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate,phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate-inorganic phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate-phosphate dikinase (phosphorylating)" EXACT [EC:2.7.9.1] synonym: "pyruvate-phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate-phosphate ligase activity" EXACT [EC:2.7.9.1] synonym: "pyruvic-phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvic-phosphate ligase activity" EXACT [EC:2.7.9.1] xref: EC:2.7.9.1 xref: KEGG:R00206 xref: MetaCyc:PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN xref: RHEA:10759 is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0050243 name: pyruvate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + NADP(+) + pyruvate = acetyl-CoA + CO(2) + NADPH." [EC:1.2.1.51, RHEA:17428] synonym: "pyruvate:NADP(+) oxidoreductase activity" EXACT [EC:1.2.1.51] synonym: "pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.51] synonym: "pyruvate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.51] xref: EC:1.2.1.51 xref: KEGG:R00210 xref: MetaCyc:PYRUVATE-DEHYDROGENASE-NADP+-RXN xref: RHEA:17428 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050244 name: pyruvate oxidase (CoA-acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + H(+) + O(2) + pyruvate = acetyl-CoA + CO(2) + H(2)O(2)." [EC:1.2.3.6, RHEA:21915] synonym: "pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.3.6] xref: EC:1.2.3.6 xref: KEGG:R00211 xref: MetaCyc:PYRUVATE-OXIDASE-COA-ACETYLATING-RXN xref: RHEA:21915 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0050245 name: quercitrinase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + quercitrin = L-rhamnose + quercetin." [EC:3.2.1.66, RHEA:17468] synonym: "quercitrin 3-L-rhamnohydrolase activity" EXACT [EC:3.2.1.66] xref: EC:3.2.1.66 xref: KEGG:R02436 xref: MetaCyc:QUERCITRINASE-RXN xref: RHEA:17468 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0050246 name: questin monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + questin = demethylsulochrin + NADP(+)." [EC:1.14.13.43, RHEA:10839] synonym: "questin oxygenase activity" EXACT [EC:1.14.13.43] synonym: "questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)" EXACT [EC:1.14.13.43] xref: EC:1.14.13.43 xref: KEGG:R02417 xref: MetaCyc:QUESTIN-MONOOXYGENASE-RXN xref: RHEA:10839 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050247 name: raucaffricine beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + raucaffricine = D-glucose + vomilenine." [EC:3.2.1.125, RHEA:14560] synonym: "raucaffricine b-glucosidase activity" EXACT [] synonym: "raucaffricine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.125] synonym: "raucaffricine beta-D-glucosidase activity" EXACT [EC:3.2.1.125] synonym: "raucaffricine glucosidase activity" EXACT [EC:3.2.1.125] xref: EC:3.2.1.125 xref: KEGG:R03703 xref: MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN xref: RHEA:14560 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050248 name: Renilla-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light." [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN] synonym: "aequorin activity" NARROW [EC:1.13.12.5] synonym: "luciferase (Renilla luciferin)" EXACT [EC:1.13.12.5] synonym: "luciferase activity" BROAD [EC:1.13.12.5] synonym: "Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.5] synonym: "Renilla-type luciferase activity" EXACT [EC:1.13.12.5] synonym: "renilla-type luciferase activity" EXACT [EC:1.13.12.5] xref: EC:1.13.12.5 xref: MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0050249 name: Renilla-luciferin sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H(+) + luciferyl sulfate." [EC:2.8.2.10, RHEA:20484] synonym: "3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity" EXACT [EC:2.8.2.10] synonym: "luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)" EXACT [EC:2.8.2.10] synonym: "luciferin sulfokinase activity" EXACT [EC:2.8.2.10] synonym: "luciferin sulfotransferase activity" BROAD [EC:2.8.2.10] synonym: "Renilla-luciferin sulphotransferase activity" EXACT [] xref: EC:2.8.2.10 xref: KEGG:R03138 xref: MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN xref: RHEA:20484 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050250 name: retinal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2." [EC:1.2.3.11, MetaCyc:RETINAL-OXIDASE-RXN] synonym: "retinal:oxygen oxidoreductase activity" EXACT [EC:1.2.3.11] synonym: "retinene oxidase activity" RELATED [EC:1.2.3.11] xref: EC:1.2.3.11 xref: MetaCyc:RETINAL-OXIDASE-RXN is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0050251 name: retinol isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinol = 11-cis-retinol." [EC:5.2.1.7, RHEA:19144] synonym: "all-trans-retinol 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.7] synonym: "all-trans-retinol isomerase activity" EXACT [EC:5.2.1.7] xref: EC:5.2.1.7 xref: KEGG:R02369 xref: MetaCyc:RETINOL-ISOMERASE-RXN xref: RHEA:19144 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0050252 name: retinol O-fatty-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester." [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:retinol O-acyltransferase activity" EXACT [EC:2.3.1.76] synonym: "retinol acyltransferase activity" EXACT [EC:2.3.1.76] synonym: "retinol fatty-acyltransferase activity" EXACT [EC:2.3.1.76] xref: EC:2.3.1.76 xref: MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0050253 name: retinyl-palmitate esterase activity namespace: molecular_function def: "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate." [EC:3.1.1.21, MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN] synonym: "retinyl ester hydrolase activity" EXACT [EC:3.1.1.21] synonym: "retinyl palmitate hydrolase activity" EXACT [EC:3.1.1.21] synonym: "retinyl palmitate hydrolyase activity" EXACT [EC:3.1.1.21] synonym: "retinyl-palmitate palmitohydrolase activity" EXACT [EC:3.1.1.21] xref: EC:3.1.1.21 xref: MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN xref: Reactome:80437 "retinyl-palmitate esterase activity" is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050254 name: rhodopsin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] synonym: "ATP:rhodopsin phosphotransferase activity" EXACT [EC:2.7.11.14] synonym: "cone opsin kinase activity" NARROW [EC:2.7.11.14] synonym: "G-protein-coupled receptor kinase 1 activity" NARROW [EC:2.7.11.14] synonym: "GPCR kinase 1 activity" NARROW [EC:2.7.11.14] synonym: "GRK1" RELATED [EC:2.7.11.14] synonym: "GRK7" RELATED [EC:2.7.11.14] synonym: "opsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14] synonym: "opsin kinase activity" EXACT [EC:2.7.11.14] synonym: "rhodopsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14] synonym: "RK" RELATED [EC:2.7.11.14] synonym: "STK14" RELATED [EC:2.7.11.14] xref: EC:2.7.11.14 xref: MetaCyc:2.7.11.14-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050255 name: ribitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribitol + NAD(+) = D-ribulose + H(+) + NADH." [EC:1.1.1.56, RHEA:20056] subset: gosubset_prok synonym: "adonitol dehydrogenase activity" EXACT [EC:1.1.1.56] synonym: "ribitol dehydrogenase A (wild type)" RELATED [EC:1.1.1.56] synonym: "ribitol dehydrogenase B (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] synonym: "ribitol dehydrogenase D (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] synonym: "ribitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.56] xref: EC:1.1.1.56 xref: KEGG:R01895 xref: MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN xref: RHEA:20056 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050256 name: ribitol-5-phosphate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+." [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.137] synonym: "dehydrogenase, ribitol 5-phosphate" EXACT [EC:1.1.1.137] xref: EC:1.1.1.137 xref: MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050257 name: riboflavin phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN." [EC:2.7.1.42, RHEA:20412] synonym: "alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42] synonym: "D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42] synonym: "G-1-P phosphotransferase activity" EXACT [EC:2.7.1.42] synonym: "riboflavine phosphotransferase activity" EXACT [EC:2.7.1.42] xref: EC:2.7.1.42 xref: KEGG:R00550 xref: MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN xref: RHEA:20412 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050258 name: riboflavinase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + H(+) + riboflavin = D-ribitol + lumichrome." [EC:3.5.99.1, RHEA:11411] synonym: "riboflavin hydrolase activity" EXACT [EC:3.5.99.1] xref: EC:3.5.99.1 xref: KEGG:R01732 xref: MetaCyc:RIBOFLAVINASE-RXN xref: RHEA:11411 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0050259 name: ribose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NADP(+) + ribofuranose = D-ribonate + 2 H(+) + NADPH." [EC:1.1.1.115, RHEA:11679] synonym: "D-ribose dehydrogenase (NADP+)" EXACT [EC:1.1.1.115] synonym: "D-ribose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.115] synonym: "NADP-pentose-dehydrogenase activity" EXACT [EC:1.1.1.115] xref: EC:1.1.1.115 xref: KEGG:R01079 xref: MetaCyc:RIBOSE-1-DEHYDROGENASE-NADP+-RXN xref: RHEA:11679 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050260 name: ribose-5-phosphate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH(4)(+) = 5-phospho-D-ribosylamine + ADP + 2 H(+) + phosphate." [EC:6.3.4.7, RHEA:13780] synonym: "5-phosphoribosylamine synthetase activity" EXACT [EC:6.3.4.7] synonym: "ammonia-ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7] synonym: "ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7] synonym: "ribose-5-phosphate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.7] xref: EC:6.3.4.7 xref: KEGG:R01053 xref: MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN xref: RHEA:13780 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0050261 name: ribose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: ribofuranose = D-ribulose." [EC:5.3.1.20, RHEA:20799] synonym: "D-ribose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.20] synonym: "D-ribose isomerase activity" EXACT [EC:5.3.1.20] synonym: "D-ribose ketol-isomerase activity" EXACT [EC:5.3.1.20] xref: EC:5.3.1.20 xref: KEGG:R01081 xref: MetaCyc:RIBOSE-ISOMERASE-RXN xref: RHEA:20799 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0050262 name: ribosylnicotinamide kinase activity namespace: molecular_function alt_id: GO:0000816 def: "Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide." [EC:2.7.1.22, RHEA:14020] synonym: "ATP:N-ribosylnicotinamide 5'-phosphotransferase activity" EXACT [EC:2.7.1.22] synonym: "nicotinamide riboside kinase activity" EXACT [PMID:15137942] synonym: "ribosylnicotinamide kinase (phosphorylating)" EXACT [EC:2.7.1.22] xref: EC:2.7.1.22 xref: KEGG:R02324 xref: MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN xref: RHEA:14020 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050263 name: ribosylpyrimidine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN] synonym: "N-ribosylpyrimidine nucleosidase activity" EXACT [EC:3.2.2.8] synonym: "N-ribosylpyrimidine ribohydrolase activity" EXACT [EC:3.2.2.8] synonym: "nucleoside ribohydrolase activity" BROAD [EC:3.2.2.8] synonym: "pyrimidine nucleosidase activity" EXACT [EC:3.2.2.8] synonym: "pyrimidine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.8] synonym: "RihB" RELATED [EC:3.2.2.8] synonym: "YeiK" RELATED [EC:3.2.2.8] xref: EC:3.2.2.8 xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0050264 name: rifamycin-B oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H(+) + O(2) + rifamycin B = H(2)O(2) + rifamycin O." [EC:1.10.3.6, RHEA:11295] synonym: "rifamycin B oxidase activity" EXACT [EC:1.10.3.6] synonym: "rifamycin-B-oxidase activity" EXACT [] synonym: "rifamycin-B:oxygen oxidoreductase activity" EXACT [EC:1.10.3.6] xref: EC:1.10.3.6 xref: KEGG:R03736 xref: MetaCyc:RIFAMYCIN-B-OXIDASE-RXN xref: RHEA:11295 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0050265 name: RNA uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN] synonym: "terminal uridylyltransferase activity" EXACT [EC:2.7.7.52] synonym: "TUT activity" EXACT [EC:2.7.7.52] synonym: "UTP:RNA uridylyltransferase activity" EXACT [] xref: EC:2.7.7.52 xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0050266 name: rosmarinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate." [EC:2.3.1.140, MetaCyc:ROSMARINATE-SYNTHASE-RXN] synonym: "4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity" EXACT [EC:2.3.1.140] synonym: "caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity" EXACT [EC:2.3.1.140] synonym: "caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity" EXACT [EC:2.3.1.140] synonym: "rosmarinic acid synthase activity" EXACT [EC:2.3.1.140] xref: EC:2.3.1.140 xref: MetaCyc:ROSMARINATE-SYNTHASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050267 name: rubber cis-polyprenylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit." [EC:2.5.1.20, MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN] synonym: "cis-prenyl transferase activity" EXACT [EC:2.5.1.20] synonym: "isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity" EXACT [EC:2.5.1.20] synonym: "poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber allyltransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber polymerase activity" EXACT [EC:2.5.1.20] synonym: "rubber prenyltransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber transferase activity" BROAD [EC:2.5.1.20] xref: EC:2.5.1.20 xref: MetaCyc:2.5.1.20-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050268 name: coniferyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH." [EC:1.1.1.194, MetaCyc:RXN-1107] synonym: "coniferyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.194] xref: EC:1.1.1.194 xref: MetaCyc:RXN-2602 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050269 name: coniferyl-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+." [EC:1.2.1.68, MetaCyc:RXN-1241] subset: gosubset_prok synonym: "coniferyl aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.68] xref: EC:1.2.1.68 xref: MetaCyc:RXN-1241 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050270 name: S-adenosylhomocysteine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H(2)O + H(+) = S-inosyl-L-homocysteine + NH(4)(+)." [EC:3.5.4.28, RHEA:20719] synonym: "adenosylhomocysteine deaminase activity" EXACT [EC:3.5.4.28] synonym: "S-adenosyl-L-homocysteine aminohydrolase activity" EXACT [EC:3.5.4.28] xref: EC:3.5.4.28 xref: KEGG:R00193 xref: MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN xref: RHEA:20719 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050271 name: S-alkylcysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate." [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN] synonym: "alkyl cysteine lyase activity" EXACT [EC:4.4.1.6] synonym: "alkylcysteine lyase activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteinase activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine lyase activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.6] synonym: "S-alkylcysteinase activity" EXACT [EC:4.4.1.6] xref: EC:4.4.1.6 xref: MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0050272 name: S-carboxymethylcysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H(+)." [EC:4.5.1.5, RHEA:22871] synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate)" EXACT [EC:4.5.1.5] synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)" EXACT [EC:4.5.1.5] synonym: "S-carboxymethyl-L-cysteine synthase activity" EXACT [EC:4.5.1.5] xref: EC:4.5.1.5 xref: KEGG:R04003 xref: MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN xref: RHEA:22871 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0050273 name: S-succinylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-succinylglutathione + H(2)O = glutathione + H(+) + succinate." [EC:3.1.2.13, RHEA:16716] xref: EC:3.1.2.13 xref: KEGG:R00499 xref: MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN xref: RHEA:16716 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0050274 name: salicyl-alcohol beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H(+) + salicin + UDP." [EC:2.4.1.172, RHEA:11515] synonym: "salicyl-alcohol b-D-glucosyltransferase activity" EXACT [] synonym: "salicyl-alcohol glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172] synonym: "UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity" EXACT [EC:2.4.1.172] synonym: "UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172] synonym: "uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity" EXACT [EC:2.4.1.172] xref: EC:2.4.1.172 xref: KEGG:R03558 xref: MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN xref: RHEA:11515 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050275 name: scopoletin glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: scopoletin + UDP-D-glucose = H(+) + scopolin + UDP." [EC:2.4.1.128, RHEA:20456] synonym: "SGTase activity" EXACT [EC:2.4.1.128] synonym: "UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128] synonym: "UDPglucose:scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128] synonym: "UDPglucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128] synonym: "uridine diphosphoglucose-scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128] xref: EC:2.4.1.128 xref: KEGG:R03594 xref: MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN xref: RHEA:20456 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050276 name: scyllo-inosamine 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.65, RHEA:18608] synonym: "ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.65] synonym: "ATP:inosamine phosphotransferase activity" EXACT [EC:2.7.1.65] synonym: "scyllo-inosamine kinase (phosphorylating)" EXACT [EC:2.7.1.65] synonym: "scyllo-inosamine kinase activity" EXACT [] xref: EC:2.7.1.65 xref: KEGG:R03384 xref: MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN xref: RHEA:18608 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050277 name: sedoheptulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate." [EC:2.7.1.14, RHEA:23847] synonym: "ATP:sedoheptulose 7-phosphotransferase activity" EXACT [EC:2.7.1.14] synonym: "heptulokinase activity" EXACT [EC:2.7.1.14] synonym: "sedoheptulokinase (phosphorylating)" EXACT [EC:2.7.1.14] xref: EC:2.7.1.14 xref: KEGG:R01844 xref: MetaCyc:SEDOHEPTULOKINASE-RXN xref: RHEA:23847 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050278 name: sedoheptulose-bisphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate." [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN] subset: gosubset_prok synonym: "SBPase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose 1,7-bisphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose 1,7-diphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose 1,7-diphosphate phosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose bisphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose diphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose-1,7-bisphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.37] xref: EC:3.1.3.37 xref: MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050279 name: sepiapterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN] synonym: "sepiapterin aminohydrolase activity" EXACT [EC:3.5.4.24] xref: EC:3.5.4.24 xref: MetaCyc:SEPIAPTERIN-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050280 name: sequoyitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.143, RHEA:11303] synonym: "5-O-methyl-myo-inositol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.143] xref: EC:1.1.1.143 xref: KEGG:R03497 xref: MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN xref: RHEA:11303 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050281 name: serine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine." [EC:2.6.1.45, MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN] subset: gosubset_prok synonym: "L-serine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.45] synonym: "serine--glyoxylate aminotransferase activity" EXACT [] synonym: "SGAT activity" EXACT [EC:2.6.1.45] xref: EC:2.6.1.45 xref: MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050282 name: serine 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH." [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN] synonym: "L-serine:NAD oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.7] synonym: "L-serine:NAD+ 2-oxidoreductase (deaminating)" EXACT [EC:1.4.1.7] synonym: "serine dehydrogenase activity" EXACT [] xref: EC:1.4.1.7 xref: MetaCyc:SERINE-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050283 name: serine-sulfate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate." [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN] synonym: "(L-SOS)lyase activity" EXACT [EC:4.3.1.10] synonym: "L-serine-O-sulfate ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.10] synonym: "serine-sulphate ammonia-lyase activity" EXACT [] xref: EC:4.3.1.10 xref: MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0050284 name: sinapate 1-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose." [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP-glucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "UDPglucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "UDPglucose:sinapic acid glucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "uridine diphosphoglucose-sinapate glucosyltransferase activity" EXACT [EC:2.4.1.120] xref: EC:2.4.1.120 xref: MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050285 name: sinapine esterase activity namespace: molecular_function def: "Catalysis of the reaction: O-sinapoylcholine + H(2)O = choline + H(+) + sinapate." [EC:3.1.1.49, RHEA:10019] synonym: "aromatic choline esterase activity" EXACT [EC:3.1.1.49] synonym: "sinapoylcholine sinapohydrolase activity" EXACT [EC:3.1.1.49] xref: EC:3.1.1.49 xref: KEGG:R02381 xref: MetaCyc:SINAPINE-ESTERASE-RXN xref: RHEA:10019 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050286 name: sorbitol-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucitol 6-phosphate + H(2)O = D-glucitol + phosphate." [EC:3.1.3.50, RHEA:24583] synonym: "sorbitol-6-phosphate phosphatase activity" EXACT [EC:3.1.3.50] synonym: "sorbitol-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.50] xref: EC:3.1.3.50 xref: KEGG:R02866 xref: MetaCyc:SORBITOL-6-PHOSPHATASE-RXN xref: RHEA:24583 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050287 name: sorbose 5-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH." [EC:1.1.1.123, RHEA:15004] synonym: "5-keto-D-fructose reductase activity" EXACT [EC:1.1.1.123] synonym: "5-ketofructose reductase activity" EXACT [EC:1.1.1.123] synonym: "L-sorbose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.123] synonym: "reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity" EXACT [EC:1.1.1.123] synonym: "sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.123] xref: EC:1.1.1.123 xref: KEGG:R01694 xref: MetaCyc:SORBOSE-5-DEHYDROGENASE-NADP+-RXN xref: RHEA:15004 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050288 name: sorbose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.12, RHEA:14716] synonym: "L-sorbose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.12] synonym: "L-sorbose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.12] xref: EC:1.1.99.12 xref: KEGG:R01696 xref: MetaCyc:SORBOSE-DEHYDROGENASE-RXN xref: RHEA:14716 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0050289 name: spermidine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor." [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN] synonym: "spermidine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.6] synonym: "spermidine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.6] xref: EC:1.5.99.6 xref: MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0050290 name: sphingomyelin phosphodiesterase D activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+)." [EC:3.1.4.41, RHEA:20987] synonym: "sphingomyelin ceramide-phosphohydrolase activity" EXACT [EC:3.1.4.41] synonym: "sphingomyelinase D" RELATED [EC:3.1.4.41] xref: EC:3.1.4.41 xref: KEGG:R02542 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN xref: RHEA:20987 is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0050291 name: sphingosine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845] synonym: "acyl-CoA:sphingosine N-acyltransferase activity" EXACT [EC:2.3.1.24] synonym: "ceramide synthase activity" EXACT [] synonym: "ceramide synthetase activity" EXACT [EC:2.3.1.24] synonym: "dihydroceramide synthase activity" EXACT [] synonym: "sphingosine acyltransferase activity" EXACT [EC:2.3.1.24] xref: EC:2.3.1.24 xref: MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN xref: Reactome:80514 "sphingosine N-acyltransferase activity" is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0050292 name: steroid 9-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H(2)O." [EC:1.14.99.24, RHEA:19560] synonym: "steroid 9-alpha-hydroxylase activity" EXACT [EC:1.14.99.24] synonym: "steroid 9a-monooxygenase activity" EXACT [] synonym: "steroid 9alpha-hydroxylase activity" EXACT [EC:1.14.99.24] synonym: "steroid 9alpha-monooxygenase activity" EXACT [EC:1.14.99.24] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)" EXACT [EC:1.14.99.24] xref: EC:1.14.99.24 xref: KEGG:R04392 xref: MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN xref: RHEA:19560 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050293 name: steroid-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + testololactone = H(+) + testolate." [EC:3.1.1.37, RHEA:13724] synonym: "testololactone lactonohydrolase activity" EXACT [EC:3.1.1.37] xref: EC:3.1.1.37 xref: KEGG:R03641 xref: MetaCyc:STEROID-LACTONASE-RXN xref: RHEA:13724 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050294 name: steroid sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" EXACT [EC:2.8.2.15] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15] synonym: "steroid sulphotransferase activity" EXACT [] xref: EC:2.8.2.15 xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN xref: Reactome:80520 "steroid sulfotransferase activity" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050295 name: steryl-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol." [EC:3.2.1.104, RHEA:11959] synonym: "cholesteryl-beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.104] synonym: "steryl-b-glucosidase activity" EXACT [] xref: EC:3.2.1.104 xref: KEGG:R01460 xref: MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN xref: RHEA:11959 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050296 name: stipitatonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + stipitatonate = CO(2) + H(+) + stipitatate." [EC:4.1.1.60, RHEA:13888] synonym: "stipitatonate carboxy-lyase (decyclizing)" EXACT [EC:4.1.1.60] synonym: "stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)" EXACT [EC:4.1.1.60] xref: EC:4.1.1.60 xref: KEGG:R03739 xref: MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN xref: RHEA:13888 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050297 name: stizolobate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN] synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.29] xref: EC:1.13.11.29 xref: MetaCyc:STIZOLOBATE-SYNTHASE-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050298 name: stizolobinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN] synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.30] xref: EC:1.13.11.30 xref: MetaCyc:STIZOLOBINATE-SYNTHASE-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050299 name: streptomycin 3''-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 3''-phosphate." [EC:2.7.1.87, RHEA:18380] subset: gosubset_prok synonym: "ATP:streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87] synonym: "streptomycin 3''-kinase (phosphorylating)" EXACT [EC:2.7.1.87] synonym: "streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87] xref: EC:2.7.1.87 xref: KEGG:R02227 xref: MetaCyc:STREPTOMYCIN-3-KINASE-RXN xref: RHEA:18380 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0050300 name: aminoglycoside 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 6-phosphate." [EC:2.7.1.72, RHEA:22271] subset: gosubset_prok synonym: "APH(6) activity" EXACT [EC:2.7.1.72] synonym: "ATP:streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] synonym: "SM 6-kinase activity" NARROW [EC:2.7.1.72] synonym: "streptidine kinase (phosphorylating)" NARROW [EC:2.7.1.72] synonym: "streptidine kinase activity" NARROW [EC:2.7.1.72] synonym: "streptomycin 6-kinase (phosphorylating)" NARROW [EC:2.7.1.72] synonym: "streptomycin 6-kinase activity" NARROW [] synonym: "streptomycin 6-O-phosphotransferase activity" NARROW [EC:2.7.1.72] synonym: "streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] xref: EC:2.7.1.72 xref: KEGG:R02225 xref: MetaCyc:STREPTOMYCIN-6-KINASE-RXN xref: RHEA:22271 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0050301 name: streptomycin-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + streptomycin 6-phosphate = phosphate + streptomycin." [EC:3.1.3.39, RHEA:10691] subset: gosubset_prok synonym: "streptomycin 6-phosphate phosphatase activity" EXACT [EC:3.1.3.39] synonym: "streptomycin 6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39] synonym: "streptomycin-6-P phosphohydrolase activity" EXACT [EC:3.1.3.39] synonym: "streptomycin-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39] xref: EC:3.1.3.39 xref: KEGG:R02228 xref: MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN xref: RHEA:10691 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050302 name: indole-3-acetaldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)acetaldehyde + H(2)O + O(2) = (indol-3-yl)acetate + H(2)O(2) + H(+)." [EC:1.2.3.7, RHEA:16280] synonym: "(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7] synonym: "AO1" RELATED [EC:1.2.3.7] synonym: "IAA oxidase activity" EXACT [EC:1.2.3.7] synonym: "IAAld oxidase activity" EXACT [EC:1.2.3.7] synonym: "indole-3-acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7] synonym: "indoleacetaldehyde oxidase activity" EXACT [EC:1.2.3.7] xref: EC:1.2.3.7 xref: KEGG:R02681 xref: MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN xref: RHEA:16280 is_a: GO:0018488 ! aryl-aldehyde oxidase activity [Term] id: GO:0050303 name: lysine 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN] synonym: "L-lysine 6-dehydrogenase activity" EXACT [EC:1.4.1.18] synonym: "L-lysine epsilon-dehydrogenase activity" EXACT [EC:1.4.1.18] synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" EXACT [EC:1.4.1.18] synonym: "LysDH activity" EXACT [EC:1.4.1.18] xref: EC:1.4.1.18 xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN xref: MetaCyc:PWY-5314 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050304 name: nitrous-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrogen + H2O + acceptor = nitrous oxide + reduced acceptor." [EC:1.7.99.6, MetaCyc:NITROUS-OXIDE-REDUCTASE-RXN] subset: gosubset_prok synonym: "N2O reductase activity" EXACT [EC:1.7.99.6] synonym: "nitrogen:(acceptor) oxidoreductase (N2O-forming)" EXACT [EC:1.7.99.6] synonym: "nitrogen:acceptor oxidoreductase (N2O-forming)" EXACT [EC:1.7.99.6] synonym: "nitrous oxide reductase activity" EXACT [EC:1.7.99.6] xref: EC:1.7.99.6 xref: MetaCyc:NITROUS-OXIDE-REDUCTASE-RXN is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0050305 name: strombine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H(2)O + NAD(+) = glycine + H(+) + NADH + pyruvate." [EC:1.5.1.22, RHEA:14064] synonym: "N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity" EXACT [EC:1.5.1.22] synonym: "N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)" EXACT [EC:1.5.1.22] synonym: "strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity" EXACT [EC:1.5.1.22] xref: EC:1.5.1.22 xref: KEGG:R00368 xref: MetaCyc:STROMBINE-DEHYDROGENASE-RXN xref: RHEA:14064 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050306 name: sucrose 1F-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose." [EC:2.4.1.99, MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN] synonym: "SST activity" EXACT [EC:2.4.1.99] synonym: "sucrose 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose-sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1'-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose fructosyltransferase activity" EXACT [EC:2.4.1.99] xref: EC:2.4.1.99 xref: MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN is_a: GO:0050738 ! fructosyltransferase activity [Term] id: GO:0050307 name: sucrose-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate." [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN] subset: gosubset_prok synonym: "sucrose 6-phosphate hydrolase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-6-phosphatase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-6F-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-phosphate hydrolase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24] xref: EC:3.1.3.24 xref: MetaCyc:SUCROSE-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050308 name: sugar-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN] synonym: "sugar-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.23] xref: EC:3.1.3.23 xref: MetaCyc:SUGAR-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050309 name: sugar-terminal-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a sugar phosphate = a sugar + phosphate; for example: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN] synonym: "sugar-omega-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.58] synonym: "xylitol-5-phosphatase activity" EXACT [EC:3.1.3.58] xref: EC:3.1.3.58 xref: MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0050310 name: sulfite dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c." [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "sulfite cytochrome c reductase activity" EXACT [EC:1.8.2.1] synonym: "sulfite-cytochrome c oxidoreductase activity" EXACT [EC:1.8.2.1] synonym: "sulfite:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.1] synonym: "sulphite dehydrogenase activity" EXACT [] xref: EC:1.8.2.1 xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor [Term] id: GO:0050311 name: sulfite reductase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin." [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN] subset: gosubset_prok synonym: "ferredoxin-sulfite reductase activity" EXACT [EC:1.8.7.1] synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" EXACT [EC:1.8.7.1] synonym: "sulphite reductase (ferredoxin) activity" EXACT [] xref: EC:1.8.7.1 xref: MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN xref: Reactome:80556 "sulfite reductase (ferredoxin) activity" is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050312 name: sulfoacetaldehyde lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite." [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN] comment: Note that EC:4.4.1.12 was deleted from EC as the reaction is performed by sulfoacetaldehyde acetyltransferase (EC:2.3.3.15). synonym: "sulphoacetaldehyde lyase activity" EXACT [] xref: EC:4.4.1.- is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0050313 name: sulfur dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfur + O2 + H2O = sulfite." [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN] synonym: "S-sulfanylglutathione:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18] synonym: "sulfur oxygenase activity" EXACT [EC:1.13.11.18] synonym: "sulfur:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18] synonym: "sulphur dioxygenase activity" EXACT [] xref: EC:1.13.11.18 xref: MetaCyc:FESGSHTHIO-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050314 name: sym-norspermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H(+)." [EC:2.5.1.23, RHEA:23247] synonym: "S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.23] xref: EC:2.5.1.23 xref: KEGG:R03271 xref: MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN xref: RHEA:23247 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050315 name: synephrine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium." [EC:4.2.1.88, RHEA:17516] synonym: "1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)" EXACT [EC:4.2.1.88] xref: EC:4.2.1.88 xref: KEGG:R03359 xref: MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN xref: RHEA:17516 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050316 name: T2-induced deoxynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP." [EC:2.7.4.12, MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN] synonym: "ATP:(d)NMP phosphotransferase activity" EXACT [EC:2.7.4.12] xref: EC:2.7.4.12 xref: MetaCyc:GMKALT-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0050317 name: tagatose kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.101, RHEA:15516] synonym: "ATP:D-tagatose 6-phosphotransferase activity" EXACT [EC:2.7.1.101] synonym: "D-tagatose 6-phosphate kinase activity" EXACT [EC:2.7.1.101] synonym: "tagatose 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.101] xref: EC:2.7.1.101 xref: KEGG:R02927 xref: MetaCyc:TAGATOSE-KINASE-RXN xref: RHEA:15516 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050318 name: tannase activity namespace: molecular_function def: "Catalysis of the reaction: digallate + H(2)O = 2 gallate + H(+)." [EC:3.1.1.20, RHEA:16368] synonym: "tannase S" RELATED [EC:3.1.1.20] synonym: "tannin acetylhydrolase activity" EXACT [EC:3.1.1.20] synonym: "tannin acylhydrolase activity" EXACT [EC:3.1.1.20] xref: EC:3.1.1.20 xref: KEGG:R00053 xref: MetaCyc:TANNASE-RXN xref: RHEA:16368 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050319 name: tartrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-tartrate + H(+) = D-glycerate + CO(2)." [EC:4.1.1.73, RHEA:13320] synonym: "(R,R)-tartrate carboxy-lyase (D-glycerate-forming)" EXACT [EC:4.1.1.73] synonym: "(R,R)-tartrate carboxy-lyase activity" EXACT [EC:4.1.1.73] xref: EC:4.1.1.73 xref: KEGG:R01751 xref: MetaCyc:TARTRATE-DECARBOXYLASE-RXN xref: RHEA:13320 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050320 name: tartrate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate." [EC:5.1.2.5, RHEA:22215] synonym: "tartaric racemase activity" EXACT [EC:5.1.2.5] xref: EC:5.1.2.5 xref: KEGG:R02546 xref: MetaCyc:TARTRATE-EPIMERASE-RXN xref: RHEA:22215 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0050321 name: tau-protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN] synonym: "[Tau protein] kinase activity" EXACT [] synonym: "ATP:tau-protein O-phosphotransferase activity" BROAD [EC:2.7.11.26] synonym: "brain protein kinase PK40erk activity" NARROW [EC:2.7.11.26] synonym: "cdk5/p20" RELATED [EC:2.7.11.26] synonym: "CDK5/p23" RELATED [EC:2.7.11.26] synonym: "glycogen synthase kinase-3beta activity" EXACT [EC:2.7.11.26] synonym: "GSK" RELATED [EC:2.7.11.26] synonym: "protein tau kinase activity" EXACT [EC:2.7.11.26] synonym: "STK31" RELATED [EC:2.7.11.26] synonym: "tau kinase activity" EXACT [EC:2.7.11.26] synonym: "tau protein kinase activity" EXACT [EC:2.7.11.26] synonym: "tau-protein kinase I activity" NARROW [EC:2.7.11.26] synonym: "tau-protein kinase II activity" NARROW [EC:2.7.11.26] synonym: "tau-tubulin kinase activity" NARROW [EC:2.7.11.26] synonym: "TPK" RELATED [EC:2.7.11.26] synonym: "TPK I" RELATED [EC:2.7.11.26] synonym: "TPK II" RELATED [EC:2.7.11.26] synonym: "TTK" RELATED [EC:2.7.11.26] xref: EC:2.7.11.26 xref: MetaCyc:TAU-PROTEIN-KINASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050322 name: taurine-2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate." [EC:2.6.1.55, MetaCyc:RXN-2301] synonym: "taurine aminotransferase activity" EXACT [] synonym: "taurine transaminase activity" EXACT [] synonym: "taurine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.55] synonym: "taurine--glutamate transaminase activity" EXACT [EC:2.6.1.55] synonym: "taurine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.55] xref: EC:2.6.1.55 xref: MetaCyc:RXN-2301 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050323 name: taurine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + H(2)O + taurine = AH(2) + NH(4)(+) + sulfoacetaldehyde." [EC:1.4.99.2, RHEA:18712] subset: gosubset_prok synonym: "taurine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.2] synonym: "taurine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.2] xref: EC:1.4.99.2 xref: KEGG:R07167 xref: MetaCyc:TAURINE-DEHYDROGENASE-RXN xref: RHEA:18712 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0050324 name: taurocyamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H(+)." [EC:2.7.3.4, RHEA:22519] synonym: "ATP:taurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.4] synonym: "ATP:taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4] synonym: "taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4] xref: EC:2.7.3.4 xref: KEGG:R03785 xref: MetaCyc:TAUROCYAMINE-KINASE-RXN xref: RHEA:22519 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0050325 name: tauropine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine." [EC:1.5.1.23, RHEA:12583] synonym: "2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23] synonym: "N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23] xref: EC:1.5.1.23 xref: KEGG:R01683 xref: MetaCyc:TAUROPINE-DEHYDROGENASE-RXN xref: RHEA:12583 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050326 name: taxifolin 8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O." [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN] synonym: "taxifolin hydroxylase activity" EXACT [] synonym: "taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.19] xref: EC:1.14.13.19 xref: MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050327 name: testosterone 17-beta-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH." [EC:1.1.1.63, MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN] synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.63] synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.63] synonym: "17beta-HSD" RELATED [EC:1.1.1.63] synonym: "17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity" EXACT [EC:1.1.1.63] synonym: "testosterone 17b-dehydrogenase activity" EXACT [] synonym: "testosterone 17beta-dehydrogenase activity" EXACT [EC:1.1.1.63] xref: EC:1.1.1.63 xref: MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN xref: Reactome:80588 "testosterone 17-beta-dehydrogenase activity" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050328 name: tetrahydroberberine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2." [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN] synonym: "(S)-tetrahydroberberine:oxygen oxidoreductase activity" EXACT [EC:1.3.3.8] synonym: "(S)-THB oxidase activity" EXACT [EC:1.3.3.8] synonym: "THB oxidase activity" EXACT [EC:1.3.3.8] xref: EC:1.3.3.8 xref: MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0050329 name: tetrahydroxypteridine cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydroxypteridine = H(+) + xanthine-8-carboxylate." [EC:5.5.1.3, RHEA:18100] synonym: "tetrahydroxypteridine lyase (isomerizing)" EXACT [EC:5.5.1.3] xref: EC:5.5.1.3 xref: KEGG:R04154 xref: MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN xref: RHEA:18100 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0050330 name: theanine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N(5)-ethyl-L-glutamine + H(2)O = L-glutamate + ethylamine." [EC:3.5.1.65, RHEA:18016] synonym: "5-N-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65] synonym: "L-theanine amidohydrolase activity" EXACT [EC:3.5.1.65] synonym: "N5-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65] xref: EC:3.5.1.65 xref: KEGG:R02930 xref: MetaCyc:THEANINE-HYDROLASE-RXN xref: RHEA:18016 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050331 name: thiamine-diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate." [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN] synonym: "ATP:thiamin-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] synonym: "ATP:thiamine-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] synonym: "protein bound thiamin diphosphate:ATP phosphoryltransferase activity" EXACT [EC:2.7.4.15] synonym: "TDP kinase activity" EXACT [EC:2.7.4.15] synonym: "thiamin diphosphate kinase activity" EXACT [GOC:curators] synonym: "thiamin diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] synonym: "thiamin pyrophosphate kinase activity" EXACT [EC:2.7.4.15] synonym: "thiamin-diphosphate kinase activity" EXACT [] synonym: "thiamine diphosphate kinase activity" EXACT [EC:2.7.4.15] xref: EC:2.7.4.15 xref: MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN xref: Reactome:80596 "thiamine-diphosphate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0050332 name: thiamine pyridinylase activity namespace: molecular_function def: "Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine." [EC:2.5.1.2, RHEA:17700] subset: gosubset_prok synonym: "pyrimidine transferase activity" EXACT [EC:2.5.1.2] synonym: "thiamin hydrolase activity" EXACT [EC:2.5.1.2] synonym: "thiamin pyridinolase activity" EXACT [EC:2.5.1.2] synonym: "thiamin pyridinylase activity" EXACT [GOC:curators] synonym: "thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2] synonym: "thiaminase I activity" NARROW [EC:2.5.1.2] synonym: "thiamine hydrolase activity" EXACT [EC:2.5.1.2] synonym: "thiamine pyridinolase activity" EXACT [EC:2.5.1.2] synonym: "thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2] xref: EC:2.5.1.2 xref: KEGG:R02863 xref: MetaCyc:THIAMIN-PYRIDINYLASE-RXN xref: RHEA:17700 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050333 name: thiamin-triphosphatase activity namespace: molecular_function alt_id: GO:0048253 def: "Catalysis of the reaction: H(2)O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate." [EC:3.6.1.28, RHEA:11747] synonym: "thiamine-triphosphatase activity" EXACT [] synonym: "thiamine-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.28] synonym: "ThTPase activity" EXACT [EC:3.6.1.28] xref: EC:3.6.1.28 xref: KEGG:R00618 xref: MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN xref: Reactome:80600 "thiamin-triphosphatase activity" xref: RHEA:11747 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0050334 name: thiaminase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)." [EC:3.5.99.2, RHEA:17512] synonym: "thiaminase II activity" NARROW [EC:3.5.99.2] xref: EC:3.5.99.2 xref: KEGG:R02133 xref: MetaCyc:THIAMINASE-RXN xref: RHEA:17512 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0050335 name: thiocyanate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate." [EC:5.99.1.1, RHEA:10007] synonym: "benzyl-thiocyanate isomerase activity" EXACT [EC:5.99.1.1] synonym: "isothiocyanate isomerase activity" EXACT [EC:5.99.1.1] xref: EC:5.99.1.1 xref: KEGG:R04010 xref: MetaCyc:THIOCYANATE-ISOMERASE-RXN xref: RHEA:10007 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0050336 name: thioethanolamine S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA." [EC:2.3.1.11, RHEA:23283] synonym: "acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity" EXACT [EC:2.3.1.11] synonym: "acetyl-CoA:thioethanolamine S-acetyltransferase activity" EXACT [EC:2.3.1.11] synonym: "thioethanolamine acetyltransferase activity" EXACT [EC:2.3.1.11] synonym: "thioltransacetylase B activity" EXACT [EC:2.3.1.11] xref: EC:2.3.1.11 xref: KEGG:R03668 xref: MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN xref: RHEA:23283 is_a: GO:0016418 ! S-acetyltransferase activity [Term] id: GO:0050337 name: thiosulfate-thiol sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide." [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN] synonym: "glutathione-dependent thiosulfate reductase activity" EXACT [EC:2.8.1.3] synonym: "sulfane reductase activity" EXACT [EC:2.8.1.3] synonym: "sulfane sulfurtransferase activity" EXACT [EC:2.8.1.3] synonym: "thiosulfate:thiol sulfurtransferase activity" EXACT [EC:2.8.1.3] synonym: "thiosulphate-thiol sulphurtransferase activity" EXACT [] xref: EC:2.8.1.3 xref: MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0050338 name: thiosulfate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c." [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN] synonym: "tetrathionate synthase activity" EXACT [EC:1.8.2.2] synonym: "thiosulfate oxidase activity" EXACT [EC:1.8.2.2] synonym: "thiosulfate-acceptor oxidoreductase activity" EXACT [EC:1.8.2.2] synonym: "thiosulfate-oxidizing enzyme" RELATED [EC:1.8.2.2] synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.2] synonym: "thiosulphate dehydrogenase activity" EXACT [] xref: EC:1.8.2.2 xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor [Term] id: GO:0050339 name: thymidine-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + H2O = dTDP + phosphate." [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN] synonym: "deoxythymidine-5'-triphosphatase activity" EXACT [EC:3.6.1.39] synonym: "dTTP nucleotidohydrolase activity" EXACT [EC:3.6.1.39] synonym: "dTTPase activity" EXACT [EC:3.6.1.39] synonym: "thymidine triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.39] xref: EC:3.6.1.39 xref: MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0050340 name: thymidylate 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate." [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN] synonym: "deoxythymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35] synonym: "deoxythymidylate phosphohydrolase activity" EXACT [EC:3.1.3.35] synonym: "deoxythymidylic 5'-nucleotidase activity" EXACT [EC:3.1.3.35] synonym: "dTMPase activity" EXACT [EC:3.1.3.35] synonym: "thymidylate 5' phosphatase activity" EXACT [] synonym: "thymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35] synonym: "thymidylate 5'-phosphohydrolase activity" EXACT [EC:3.1.3.35] synonym: "thymidylate nucleotidase activity" EXACT [EC:3.1.3.35] xref: EC:3.1.3.35 xref: MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050341 name: thymine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2." [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN] synonym: "5-hydroxy-methyluracil dioxygenase activity" EXACT [EC:1.14.11.6] synonym: "5-hydroxymethyluracil oxygenase activity" EXACT [EC:1.14.11.6] synonym: "thymine 7-hydroxylase activity" EXACT [EC:1.14.11.6] synonym: "thymine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.6] synonym: "thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.11.6] xref: EC:1.14.11.6 xref: MetaCyc:THYMINE-DIOXYGENASE-RXN is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0050342 name: tocopherol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol." [EC:2.1.1.95, MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN] synonym: "gamma-tocopherol methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity" EXACT [EC:2.1.1.95] xref: EC:2.1.1.95 xref: MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0050343 name: trans-2-enoyl-CoA reductase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH." [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN] synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.44] xref: EC:1.3.1.44 xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050344 name: trans-cinnamate 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamate + H(+) + NADPH + O(2) = 2-coumarate + H(2)O + NADP(+)." [EC:1.14.13.14, RHEA:10959] synonym: "cinnamate 2-hydroxylase activity" EXACT [EC:1.14.13.14] synonym: "cinnamate 2-monooxygenase activity" EXACT [EC:1.14.13.14] synonym: "cinnamic 2-hydroxylase activity" EXACT [EC:1.14.13.14] synonym: "cinnamic acid 2-hydroxylase activity" EXACT [EC:1.14.13.14] synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.14] synonym: "trans-cinnamic acid 2-hydroxylase activity" EXACT [] xref: EC:1.14.13.14 xref: KEGG:R02254 xref: MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN xref: RHEA:10959 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050345 name: trans-epoxysuccinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2,3-epoxysuccinate + H(2)O = (2R,3S)-tartrate." [EC:3.3.2.4, RHEA:20743] synonym: "tartrate epoxydase activity" EXACT [EC:3.3.2.4] synonym: "trans-2,3-epoxysuccinate hydrolase activity" EXACT [EC:3.3.2.4] synonym: "trans-epoxysuccinate hydratase activity" EXACT [EC:3.3.2.4] xref: EC:3.3.2.4 xref: KEGG:R02547 xref: MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN xref: RHEA:20743 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0050346 name: trans-L-3-hydroxyproline dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+)." [EC:4.2.1.77, RHEA:10323] synonym: "trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)" EXACT [EC:4.2.1.77] synonym: "trans-L-3-hydroxyproline hydro-lyase activity" EXACT [EC:4.2.1.77] xref: EC:4.2.1.77 xref: KEGG:R04374 xref: MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN xref: RHEA:10323 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050347 name: trans-octaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate." [EC:2.5.1.11, RHEA:11327] synonym: "(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity" EXACT [EC:2.5.1.11] synonym: "all-trans-nonaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.11] synonym: "nonaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "polyprenylpyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "solanesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "solanesyl-diphosphate synthase activity" EXACT [EC:2.5.1.11] synonym: "SPP synthase activity" EXACT [EC:2.5.1.11] synonym: "terpenoidallyltransferase activity" EXACT [EC:2.5.1.11] synonym: "terpenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "trans-prenyltransferase activity" EXACT [EC:2.5.1.11] xref: EC:2.5.1.11 xref: KEGG:R07267 xref: MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN xref: RHEA:11327 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050348 name: trehalose O-mycolyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose." [EC:2.3.1.122, RHEA:23475] subset: gosubset_prok synonym: "alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity" EXACT [EC:2.3.1.122] synonym: "alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity" EXACT [EC:2.3.1.122] xref: EC:2.3.1.122 xref: KEGG:R07248 xref: MetaCyc:RXN1G-874 xref: RHEA:23475 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050349 name: triacetate-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + triacetate lactone = triacetate." [EC:3.1.1.38, RHEA:22263] synonym: "TAL hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetate lactone hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetic acid lactone hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetic lactone hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetolactone lactonohydrolase activity" EXACT [EC:3.1.1.38] xref: EC:3.1.1.38 xref: KEGG:R03702 xref: MetaCyc:TRIACETATE-LACTONASE-RXN xref: RHEA:22263 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050350 name: trihydroxystilbene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2." [EC:2.3.1.95, MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.95] synonym: "resveratrol synthase activity" EXACT [EC:2.3.1.95] synonym: "stilbene synthase activity" BROAD [EC:2.3.1.95] xref: EC:2.3.1.95 xref: MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050351 name: trimetaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + trimetaphosphate = 2 H(+) + triphosphate." [EC:3.6.1.2, RHEA:11091] subset: gosubset_prok synonym: "inorganic trimetaphosphatase activity" EXACT [EC:3.6.1.2] synonym: "trimetaphosphate hydrolase activity" EXACT [EC:3.6.1.2] xref: EC:3.6.1.2 xref: KEGG:R02504 xref: MetaCyc:TRIMETAPHOSPHATASE-RXN xref: RHEA:11091 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0050352 name: trimethylamine-oxide aldolase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde." [EC:4.1.2.32, RHEA:20220] synonym: "trimethylamine N-oxide aldolase activity" EXACT [EC:4.1.2.32] synonym: "trimethylamine N-oxide demethylase activity" EXACT [EC:4.1.2.32] synonym: "trimethylamine N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32] synonym: "trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)" EXACT [EC:4.1.2.32] synonym: "trimethylamine-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32] xref: EC:4.1.2.32 xref: KEGG:R02512 xref: MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN xref: RHEA:20220 xref: UM-BBD_reactionID:r1409 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050353 name: trimethyllysine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate." [EC:1.14.11.8, RHEA:14184] synonym: "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8] synonym: "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8] synonym: "TML dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "TML hydroxylase activity" EXACT [EC:1.14.11.8] synonym: "TML-alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "TMLD activity" EXACT [EC:1.14.11.8] synonym: "trimethyllysine alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "trimethyllysine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] xref: EC:1.14.11.8 xref: KEGG:R03451 xref: MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN xref: Reactome:80640 "trimethyllysine dioxygenase activity" xref: RHEA:14184 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0050354 name: triokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.28, RHEA:13944] synonym: "ATP:D-glyceraldehyde 3-phosphotransferase activity" EXACT [EC:2.7.1.28] synonym: "D-triokinase activity" EXACT [EC:2.7.1.28] synonym: "trio triose kinase (phosphorylating)" EXACT [EC:2.7.1.28] synonym: "triose kinase activity" EXACT [EC:2.7.1.28] xref: EC:2.7.1.28 xref: KEGG:R01059 xref: MetaCyc:TRIOKINASE-RXN xref: Reactome:70343 "triokinase activity" xref: RHEA:13944 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050355 name: triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate." [EC:3.6.1.25, RHEA:14160] subset: gosubset_prok synonym: "inorganic triphosphatase activity" EXACT [EC:3.6.1.25] synonym: "triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.25] xref: EC:3.6.1.25 xref: KEGG:R00138 xref: MetaCyc:TRIPHOSPHATASE-RXN xref: RHEA:14160 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0050356 name: tropine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + tropine = H(+) + NADPH + tropinone." [EC:1.1.1.206, RHEA:18360] synonym: "tropine:NADP+ 3alpha-oxidoreductase activity" EXACT [EC:1.1.1.206] xref: EC:1.1.1.206 xref: KEGG:R02832 xref: MetaCyc:TROPINE-DEHYDROGENASE-RXN xref: RHEA:18360 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050357 name: tropinesterase activity namespace: molecular_function def: "Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine." [EC:3.1.1.10, RHEA:23307] subset: gosubset_prok synonym: "atropinase activity" EXACT [EC:3.1.1.10] synonym: "atropine acylhydrolase activity" EXACT [EC:3.1.1.10] synonym: "atropine esterase activity" EXACT [EC:3.1.1.10] synonym: "atropinesterase activity" EXACT [EC:3.1.1.10] synonym: "tropine esterase activity" EXACT [EC:3.1.1.10] xref: EC:3.1.1.10 xref: KEGG:R03563 xref: MetaCyc:TROPINESTERASE-RXN xref: RHEA:23307 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050358 name: tropinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + pseudotropine = H(+) + NADPH + tropinone." [EC:1.1.1.236, RHEA:24247] synonym: "pseudotropine forming tropinone reductase activity" EXACT [EC:1.1.1.236] synonym: "pseudotropine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.236] synonym: "tropinone (psi-tropine-forming) reductase activity" EXACT [EC:1.1.1.236] synonym: "tropinone reductase II activity" RELATED [EC:1.1.1.236] xref: EC:1.1.1.236 xref: KEGG:R06734 xref: MetaCyc:TROPINONE-REDUCTASE-RXN xref: RHEA:24247 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050359 name: tropomyosin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin." [EC:2.7.11.28, MetaCyc:TROPOMYOSIN-KINASE-RXN] synonym: "ATP:tropomyosin O-phosphotransferase activity" EXACT [EC:2.7.11.28] synonym: "STK" RELATED [EC:2.7.11.28] synonym: "tropomyosin kinase (phosphorylating) activity" EXACT [EC:2.7.11.28] xref: EC:2.7.11.28 xref: MetaCyc:TROPOMYOSIN-KINASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050360 name: tryptophan 2'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3." [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN] synonym: "indole-3-alkane alpha-hydroxylase activity" EXACT [EC:1.13.99.3] synonym: "indolyl-3-alkan alpha-hydroxylase activity" EXACT [EC:1.13.99.3] synonym: "L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)" EXACT [EC:1.13.99.3] synonym: "tryptophan side chain oxidase activity" EXACT [EC:1.13.99.3] synonym: "tryptophan side chain oxidase II" RELATED [EC:1.13.99.3] synonym: "tryptophan side chain oxidase type I" RELATED [EC:1.13.99.3] synonym: "tryptophan side-chain alpha,beta-oxidase activity" RELATED [EC:1.13.99.3] synonym: "tryptophan side-chain oxidase activity" RELATED [EC:1.13.99.3] synonym: "TSO activity" RELATED [EC:1.13.99.3] synonym: "TSO I" RELATED [EC:1.13.99.3] synonym: "TSO II" RELATED [EC:1.13.99.3] xref: EC:1.13.99.3 xref: MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0050361 name: tryptophan 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O(2) = CO(2) + H(2)O + indole-3-acetamide." [EC:1.13.12.3, RHEA:16168] subset: gosubset_prok synonym: "L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.3] xref: EC:1.13.12.3 xref: KEGG:R00679 xref: MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN xref: RHEA:16168 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050362 name: L-tryptophan:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate." [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN] synonym: "5-hydroxytryptophan-ketoglutaric transaminase activity" RELATED [EC:2.6.1.27] synonym: "hydroxytryptophan aminotransferase activity" RELATED [EC:2.6.1.27] synonym: "L-phenylalanine-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.27] synonym: "L-tryptophan aminotransferase activity" BROAD [EC:2.6.1.27] synonym: "L-tryptophan transaminase activity" BROAD [EC:2.6.1.27] synonym: "tryptophan aminotransferase activity" EXACT [] synonym: "tryptophan transaminase activity" BROAD [EC:2.6.1.27] xref: EC:2.6.1.27 xref: MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN is_a: GO:0070529 ! L-tryptophan aminotransferase activity [Term] id: GO:0050363 name: tryptophan dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+." [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN] synonym: "L-Trp-dehydrogenase activity" EXACT [EC:1.4.1.19] synonym: "L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19] synonym: "L-tryptophan:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.19] synonym: "NAD(P)+-L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19] synonym: "TDH" RELATED [EC:1.4.1.19] synonym: "TrpDH activity" EXACT [EC:1.4.1.19] xref: EC:1.4.1.19 xref: MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050364 name: tryptophan dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan." [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN] synonym: "4-(gamma,gamma-dimethylallyl)tryptophan synthase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallyltryptophan synthetase activity" EXACT [EC:2.5.1.34] synonym: "DMAT synthetase activity" EXACT [EC:2.5.1.34] xref: EC:2.5.1.34 xref: MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050365 name: tryptophanamidase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophanamide + H(2)O = L-tryptophan + NH(4)(+)." [EC:3.5.1.57, RHEA:11015] synonym: "L-tryptophan aminopeptidase" BROAD [EC:3.5.1.57] synonym: "L-tryptophanamide amidohydrolase activity" EXACT [EC:3.5.1.57] synonym: "tryptophan aminopeptidase" BROAD [EC:3.5.1.57] xref: EC:3.5.1.57 xref: KEGG:R00682 xref: MetaCyc:TRYPTOPHANAMIDASE-RXN xref: RHEA:11015 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050366 name: tyramine N-feruloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine." [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN] synonym: "feruloyl-CoA tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110] synonym: "feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.110] synonym: "feruloyltyramine synthase activity" EXACT [EC:2.3.1.110] synonym: "tyramine feruloyltransferase activity" EXACT [EC:2.3.1.110] synonym: "tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110] xref: EC:2.3.1.110 xref: MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050367 name: tyrosine-arginine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+)." [EC:6.3.2.24, RHEA:15348] synonym: "kyotorphin synthase activity" EXACT [EC:6.3.2.24] synonym: "kyotorphin synthetase activity" EXACT [EC:6.3.2.24] synonym: "kyotorphin-synthesizing enzyme activity" EXACT [EC:6.3.2.24] synonym: "L-tyrosine:L-arginine ligase (AMP-forming)" EXACT [EC:6.3.2.24] synonym: "tyrosyl-arginine synthase activity" EXACT [EC:6.3.2.24] xref: EC:6.3.2.24 xref: KEGG:R00735 xref: MetaCyc:TYROSINE--ARGININE-LIGASE-RXN xref: RHEA:15348 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0050368 name: tyrosine 2,3-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate." [EC:5.4.3.6, RHEA:15784] synonym: "L-tyrosine 2,3-aminomutase activity" EXACT [EC:5.4.3.6] synonym: "tyrosine alpha,beta-mutase activity" EXACT [EC:5.4.3.6] xref: EC:5.4.3.6 xref: KEGG:R00739 xref: MetaCyc:TYROSINE-23-AMINOMUTASE-RXN xref: RHEA:15784 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0050369 name: [tyrosine 3-monooxygenase] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]." [EC:2.7.11.6, MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN] synonym: "ATP:tyrosine-3-monoxygenase phosphotransferase activity" EXACT [EC:2.7.11.6] synonym: "pheochromocytoma tyrosine hydroxylase-associated kinase activity" EXACT [EC:2.7.11.6] synonym: "STK4" RELATED [EC:2.7.11.6] synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.6] synonym: "tyrosine 3-monooxygenase kinase activity" EXACT [] xref: EC:2.7.11.6 xref: MetaCyc:2.7.11.6-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050370 name: tyrosine N-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O." [EC:1.14.13.41, MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN] synonym: "CYP79A1 activity" NARROW [EC:1.14.13.41] synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT [EC:1.14.13.41] synonym: "tyrosine N-hydroxylase activity" EXACT [] xref: EC:1.14.13.41 xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050371 name: tyrosine phenol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + H(2)O = NH(4)(+) + phenol + pyruvate." [EC:4.1.99.2, RHEA:21707] subset: gosubset_prok synonym: "beta-tyrosinase activity" EXACT [EC:4.1.99.2] synonym: "L-tyrosine phenol-lyase (deaminating)" EXACT [EC:4.1.99.2] synonym: "L-tyrosine phenol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.1.99.2] xref: EC:4.1.99.2 xref: KEGG:R00728 xref: MetaCyc:TYROSINE-PHENOL-LYASE-RXN xref: RHEA:21707 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0050372 name: ubiquitin-calmodulin ligase activity namespace: molecular_function def: "Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin." [EC:6.3.2.21, MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN] synonym: "calmodulin:ubiquitin ligase (AMP-forming)" EXACT [EC:6.3.2.21] synonym: "ubiquitin-calmodulin synthetase activity" EXACT [EC:6.3.2.21] synonym: "ubiquityl-calmodulin synthase activity" EXACT [EC:6.3.2.21] synonym: "ubiquityl-calmodulin synthetase activity" EXACT [EC:6.3.2.21] synonym: "uCaM-synthetase activity" EXACT [EC:6.3.2.21] xref: EC:6.3.2.21 xref: MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN is_a: GO:0004842 ! ubiquitin-protein ligase activity [Term] id: GO:0050373 name: UDP-arabinose 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose." [EC:5.1.3.5, RHEA:11323] synonym: "UDP arabinose epimerase activity" EXACT [EC:5.1.3.5] synonym: "UDP-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "UDP-D-xylose-4-epimerase activity" EXACT [] synonym: "UDP-L-arabinose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "UDParabinose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "uridine 5'-diphosphate-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "uridine diphosphoarabinose epimerase activity" EXACT [EC:5.1.3.5] xref: EC:5.1.3.5 xref: KEGG:R01473 xref: MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN xref: RHEA:11323 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050374 name: UDP-galacturonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + UDP-alpha-D-galacturonate = CO(2) + UDP-L-arabinose." [EC:4.1.1.67, RHEA:19728] synonym: "UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)" EXACT [EC:4.1.1.67] synonym: "UDP-D-galacturonate carboxy-lyase activity" EXACT [EC:4.1.1.67] synonym: "UDP-galacturonic acid decarboxylase activity" EXACT [EC:4.1.1.67] synonym: "UDPgalacturonate decarboxylase activity" EXACT [EC:4.1.1.67] synonym: "UDPGalUA carboxy lyase activity" EXACT [EC:4.1.1.67] xref: EC:4.1.1.67 xref: KEGG:R02636 xref: MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN xref: RHEA:19728 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050376 name: UDP-glucosamine 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine." [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN] synonym: "UDP-glucosamine epimerase activity" EXACT [] synonym: "UDPglucosamine 4-epimerase activity" EXACT [EC:5.1.3.16] xref: EC:5.1.3.16 xref: MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050377 name: UDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucose = H(2)O + UDP-4-dehydro-6-deoxy-D-glucose." [EC:4.2.1.76, RHEA:21503] synonym: "UDP-D-glucose oxidoreductase activity" EXACT [EC:4.2.1.76] synonym: "UDP-D-glucose-4,6-hydrolyase activity" EXACT [EC:4.2.1.76] synonym: "UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.76] synonym: "UDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76] synonym: "UDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.76] synonym: "UDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76] xref: EC:4.2.1.76 xref: KEGG:R00293 xref: MetaCyc:UDP-GLUCOSE-46-DEHYDRATASE-RXN xref: RHEA:21503 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050378 name: UDP-glucuronate 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate." [EC:5.1.3.6, RHEA:11407] synonym: "UDP glucuronic epimerase activity" EXACT [EC:5.1.3.6] synonym: "UDP-D-galacturonic acid 4-epimerase activity" EXACT [EC:5.1.3.6] synonym: "UDP-galacturonate 4-epimerase activity" EXACT [EC:5.1.3.6] synonym: "UDPglucuronate 4-epimerase activity" EXACT [EC:5.1.3.6] synonym: "uridine diphospho-D-galacturonic acid" RELATED [EC:5.1.3.6] synonym: "uridine diphosphoglucuronate epimerase activity" EXACT [EC:5.1.3.6] synonym: "uridine diphosphoglucuronic epimerase activity" EXACT [EC:5.1.3.6] xref: EC:5.1.3.6 xref: KEGG:R01385 xref: MetaCyc:PWY-4861 xref: MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN xref: RHEA:11407 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050379 name: UDP-glucuronate 5'-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate." [EC:5.1.3.12, RHEA:14680] subset: gosubset_prok synonym: "C-5-uronosyl epimerase activity" EXACT [EC:5.1.3.12] synonym: "UDP-glucuronate 5' epimerase activity" EXACT [] synonym: "UDP-glucuronic acid 5'-epimerase activity" EXACT [EC:5.1.3.12] synonym: "UDP-glucuronic acid epimerase activity" EXACT [EC:5.1.3.12] synonym: "UDPglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12] synonym: "uridine diphosphoglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12] xref: EC:5.1.3.12 xref: KEGG:R01387 xref: MetaCyc:UDP-GLUCURONATE-5-EPIMERASE-RXN xref: RHEA:14680 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050380 name: undecaprenyl-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-undecaprenyl diphosphate + H(2)O = all-trans-undecaprenyl phosphate + H(+) + phosphate." [EC:3.6.1.27, RHEA:17072] subset: gosubset_prok synonym: "C(55)-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27] synonym: "C(55)-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] synonym: "C55-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27] synonym: "C55-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] synonym: "isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] synonym: "undecaprenyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.27] xref: EC:3.6.1.27 xref: KEGG:R05627 xref: MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN xref: RHEA:17072 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0050382 name: uracil-5-carboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + uracil 5-carboxylate = CO(2) + uracil." [EC:4.1.1.66, RHEA:17688] synonym: "uracil-5-carboxylate carboxy-lyase (uracil-forming)" EXACT [EC:4.1.1.66] synonym: "uracil-5-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.66] synonym: "uracil-5-carboxylic acid decarboxylase activity" EXACT [EC:4.1.1.66] xref: EC:4.1.1.66 xref: KEGG:R00973 xref: MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN xref: RHEA:17688 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050383 name: uracil dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [EC:1.17.99.4, MetaCyc:URACIL-DEHYDROGENASE-RXN] xref: EC:1.17.99.4 xref: MetaCyc:URACIL-DEHYDROGENASE-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0050384 name: urate-ribonucleotide phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H(+) + urate." [EC:2.4.2.16, RHEA:13912] synonym: "UAR phosphorylase activity" EXACT [EC:2.4.2.16] synonym: "urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.16] synonym: "urate-ribonucleotide:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.16] xref: EC:2.4.2.16 xref: KEGG:R02646 xref: MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN xref: RHEA:13912 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0050385 name: ureidoglycolate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea." [EC:4.3.2.3, RHEA:11307] synonym: "(S)-ureidoglycolate urea-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.3] synonym: "(S)-ureidoglycolate urea-lyase activity" EXACT [EC:4.3.2.3] synonym: "ureidoglycolase activity" RELATED [EC:4.3.2.3] synonym: "ureidoglycolatase activity" RELATED [EC:4.3.2.3] xref: EC:4.3.2.3 xref: KEGG:R00776 xref: MetaCyc:UREIDOGLYCOLATE-LYASE-RXN xref: RHEA:11307 is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0050386 name: ureidosuccinase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-L-aspartate + H(2)O + 2 H(+) = L-aspartate + CO(2) + NH(4)(+)." [EC:3.5.1.7, RHEA:14368] synonym: "N-carbamoyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.7] xref: EC:3.5.1.7 xref: KEGG:R00484 xref: MetaCyc:UREIDOSUCCINASE-RXN xref: RHEA:14368 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050387 name: urethanase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + H(+) + urethane = CO(2) + ethanol + NH(4)(+)." [EC:3.5.1.75, RHEA:21375] synonym: "urethane amidohydrolase (decarboxylating)" EXACT [EC:3.5.1.75] synonym: "urethane hydrolase activity" EXACT [EC:3.5.1.75] xref: EC:3.5.1.75 xref: KEGG:R02359 xref: MetaCyc:URETHANASE-RXN xref: RHEA:21375 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050388 name: uronate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-galacturonate + H(2)O + NAD(+) = galactarate + 2 H(+) + NADH." [EC:1.1.1.203, RHEA:22407] synonym: "uronate: NAD-oxidoreductase activity" EXACT [EC:1.1.1.203] synonym: "uronate:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.203] synonym: "uronic acid dehydrogenase activity" EXACT [EC:1.1.1.203] xref: EC:1.1.1.203 xref: KEGG:R01981 xref: MetaCyc:URONATE-DEHYDROGENASE-RXN xref: RHEA:22407 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050389 name: uronolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate." [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN] synonym: "D-glucurono-6,2-lactone lactonohydrolase activity" EXACT [EC:3.1.1.19] synonym: "glucuronolactonase activity" EXACT [EC:3.1.1.19] xref: EC:3.1.1.19 xref: MetaCyc:URONOLACTONASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050390 name: valine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + H(+) = 2-methylpropanamine + CO(2)." [EC:4.1.1.14, RHEA:18992] synonym: "L-valine carboxy-lyase (2-methylpropanamine-forming)" EXACT [EC:4.1.1.14] synonym: "L-valine carboxy-lyase activity" EXACT [EC:4.1.1.14] synonym: "l-valine carboxy-lyase activity" EXACT [EC:4.1.1.14] synonym: "leucine decarboxylase activity" EXACT [EC:4.1.1.14] xref: EC:4.1.1.14 xref: KEGG:R01437 xref: MetaCyc:VALINE-DECARBOXYLASE-RXN xref: RHEA:18992 xref: UM-BBD_reactionID:r1052 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050391 name: valine dehydrogenase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH." [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN] synonym: "L-valine:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.8] synonym: "valine dehydrogenase (NADP+) activity" EXACT [] synonym: "valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)" EXACT [EC:1.4.1.8] xref: EC:1.4.1.8 xref: MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050392 name: vicianin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-vicianin + H(2)O = mandelonitrile + vicianose." [EC:3.2.1.119, RHEA:14044] synonym: "(R)-vicianin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.119] synonym: "vicianin b-glucosidase activity" EXACT [] synonym: "vicianin hydrolase activity" EXACT [EC:3.2.1.119] xref: EC:3.2.1.119 xref: KEGG:R03642 xref: MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN xref: RHEA:14044 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050393 name: vinylacetyl-CoA delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: vinylacetyl-CoA = crotonoyl-CoA." [EC:5.3.3.3, RHEA:10575] subset: gosubset_prok synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.3] synonym: "vinylacetyl coenzyme A delta-isomerase activity" EXACT [EC:5.3.3.3] synonym: "vinylacetyl coenzyme A isomerase activity" EXACT [EC:5.3.3.3] synonym: "vinylacetyl-CoA D-isomerase activity" EXACT [] synonym: "vinylacetyl-CoA delta3-delta2-isomerase activity" EXACT [EC:5.3.3.3] xref: EC:5.3.3.3 xref: KEGG:R03031 xref: MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN xref: RHEA:10575 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0050394 name: viomycin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin." [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN] subset: gosubset_prok synonym: "ATP:viomycin O-phosphotransferase activity" EXACT [EC:2.7.1.103] synonym: "capreomycin phosphotransferase activity" EXACT [EC:2.7.1.103] synonym: "viomycin phosphotransferase activity" EXACT [EC:2.7.1.103] xref: EC:2.7.1.103 xref: MetaCyc:VIOMYCIN-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050395 name: vitexin beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside." [EC:2.4.1.105, RHEA:21959] synonym: "UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105] synonym: "UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105] synonym: "uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.105] synonym: "vitexin b-glucosyltransferase activity" EXACT [] xref: EC:2.4.1.105 xref: KEGG:R03565 xref: MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:21959 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050396 name: vomifoliol 4'-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH." [EC:1.1.1.221, RHEA:22807] synonym: "vomifoliol:NAD+ 4'-oxidoreductase activity" EXACT [EC:1.1.1.221] xref: EC:1.1.1.221 xref: KEGG:R04412 xref: MetaCyc:VOMIFOLIOL-4-DEHYDROGENASE-RXN xref: RHEA:22807 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050397 name: Watasenia-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light." [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN] synonym: "luciferase activity" BROAD [EC:1.13.12.8] synonym: "Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.8] synonym: "Watasenia-type luciferase activity" EXACT [EC:1.13.12.8] synonym: "watasenia-type luciferase activity" EXACT [EC:1.13.12.8] xref: EC:1.13.12.8 xref: MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0050398 name: wax-ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate." [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN] synonym: "jojoba wax esterase" NARROW [EC:3.1.1.50] synonym: "wax-ester acylhydrolase activity" EXACT [EC:3.1.1.50] synonym: "WEH" RELATED [EC:3.1.1.50] xref: EC:3.1.1.50 xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050399 name: xanthommatin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin." [EC:1.3.1.41, RHEA:13420] synonym: "5,12-dihydroxanthommatin:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.41] xref: EC:1.3.1.41 xref: KEGG:R03787 xref: MetaCyc:XANTHOMMATIN-REDUCTASE-RXN xref: RHEA:13420 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050400 name: xylitol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xylitol = ADP + 2 H(+) + xylitol 5-phosphate." [EC:2.7.1.122, RHEA:20212] synonym: "ATP:xylitol 5-phosphotransferase activity" EXACT [EC:2.7.1.122] synonym: "xylitol phosphotransferase activity" EXACT [EC:2.7.1.122] xref: EC:2.7.1.122 xref: KEGG:R02136 xref: MetaCyc:XYLITOL-KINASE-RXN xref: RHEA:20212 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050401 name: xylonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O." [EC:4.2.1.82, RHEA:19160] synonym: "D-xylo-aldonate dehydratase activity" EXACT [EC:4.2.1.82] synonym: "D-xylonate dehydratase activity" EXACT [EC:4.2.1.82] synonym: "D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)" EXACT [EC:4.2.1.82] synonym: "D-xylonate hydro-lyase activity" EXACT [EC:4.2.1.82] xref: EC:4.2.1.82 xref: KEGG:R02429 xref: MetaCyc:XYLONATE-DEHYDRATASE-RXN xref: RHEA:19160 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050402 name: xylono-1,4-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate." [EC:3.1.1.68, MetaCyc:XYLONO-14-LACTONASE-RXN] synonym: "D-xylono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.68] synonym: "xylono-g-lactonase activity" EXACT [EC:3.1.1.68] synonym: "xylonolactonase activity" EXACT [EC:3.1.1.68] xref: EC:3.1.1.68 xref: MetaCyc:XYLONO-14-LACTONASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050403 name: trans-zeatin O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H(+) + UDP." [EC:2.4.1.203, RHEA:23227] synonym: "UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "uridine diphosphoglucose-zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "zeatin O-b-D-glucosyltransferase activity" EXACT [] synonym: "zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203] xref: EC:2.4.1.203 xref: KEGG:R02118 xref: MetaCyc:RXN-4723 xref: RHEA:23227 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050404 name: zeatin O-beta-D-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H(+) + UDP." [EC:2.4.2.40, RHEA:14724] comment: Note that this function was formerly EC:2.4.1.204. synonym: "UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.40] synonym: "uridine diphosphoxylose-zeatin xylosyltransferase activity" EXACT [EC:2.4.2.40] synonym: "zeatin O-b-D-xylosyltransferase activity" EXACT [] synonym: "zeatin O-xylosyltransferase activity" EXACT [EC:2.4.2.40] xref: EC:2.4.2.40 xref: KEGG:R02119 xref: MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN xref: RHEA:14724 is_a: GO:0035252 ! UDP-xylosyltransferase activity [Term] id: GO:0050405 name: [acetyl-CoA carboxylase] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate." [EC:2.7.11.27, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN] synonym: "acetyl coenzyme A carboxylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase bound kinase activity" NARROW [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase (AMP-activated) activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase (cAMP-independent) activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase 2 activity" NARROW [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase-2 activity" NARROW [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase-3 (AMP-activated) activity" NARROW [EC:2.7.11.27] synonym: "acetyl-coenzyme A carboxylase kinase activity" EXACT [EC:2.7.11.27] synonym: "ACK2" RELATED [EC:2.7.11.27] synonym: "ACK3" RELATED [EC:2.7.11.27] synonym: "AMPK" RELATED [EC:2.7.11.27] synonym: "ATP:acetyl-CoA carboxylase phosphotransferase activity" EXACT [EC:2.7.11.27] synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27] synonym: "STK5" RELATED [EC:2.7.11.27] xref: EC:2.7.11.27 xref: MetaCyc:2.7.11.27-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050406 name: [acetyl-CoA carboxylase]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate." [EC:3.1.3.44, MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN] synonym: "acetyl-CoA carboxylase-phosphatase activity" EXACT [EC:3.1.3.44] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.44] xref: EC:3.1.3.44 xref: MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050407 name: [glycogen-synthase-D] phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate." [EC:3.1.3.42, MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN] synonym: "glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen synthase D phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen synthetase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen-synthase-D phosphatase activity" EXACT [EC:3.1.3.42] synonym: "Mg2+ dependent glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "phosphatase type 2oC" RELATED [EC:3.1.3.42] synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42] synonym: "UDP-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "UDPglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42] synonym: "uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] xref: EC:3.1.3.42 xref: MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050408 name: [pyruvate kinase]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate." [EC:3.1.3.49, MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN] synonym: "ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.49] synonym: "pyruvate kinase phosphatase activity" EXACT [EC:3.1.3.49] synonym: "pyruvate kinase-phosphatase activity" EXACT [EC:3.1.3.49] xref: EC:3.1.3.49 xref: MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050409 name: indolylacetylinositol arabinosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP." [EC:2.4.2.34, RHEA:19508] subset: gosubset_prok synonym: "arabinosylindolylacetylinositol synthase activity" EXACT [EC:2.4.2.34] synonym: "UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34] synonym: "UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34] xref: EC:2.4.2.34 xref: KEGG:R04335 xref: MetaCyc:2.4.2.34-RXN xref: RHEA:19508 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0052636 ! arabinosyltransferase activity [Term] id: GO:0050410 name: 3-oxolaurate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxolaurate + H(+) = 2-undecanone + CO(2)." [EC:4.1.1.56, RHEA:13388] synonym: "3-oxododecanoate carboxy-lyase (2-undecanone-forming)" EXACT [EC:4.1.1.56] synonym: "3-oxododecanoate carboxy-lyase activity" EXACT [EC:4.1.1.56] synonym: "beta-ketoacyl decarboxylase activity" EXACT [EC:4.1.1.56] synonym: "beta-ketolaurate decarboxylase activity" EXACT [EC:4.1.1.56] xref: EC:4.1.1.56 xref: KEGG:R03747 xref: MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN xref: RHEA:13388 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050411 name: agaritine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor." [EC:2.3.2.9, MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN] synonym: "(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9] synonym: "(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9] synonym: "agaritine g-glutamyltransferase activity" EXACT [] xref: EC:2.3.2.9 xref: MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0050412 name: cinnamate beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP." [EC:2.4.1.177, RHEA:13440] synonym: "cinnamate b-D-glucosyltransferase activity" EXACT [] synonym: "cinnamate glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177] synonym: "UDPG:t-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177] synonym: "UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177] synonym: "uridine diphosphoglucose-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177] xref: EC:2.4.1.177 xref: KEGG:R02256 xref: MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN xref: RHEA:13440 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050413 name: D-alanine 2-hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine." [EC:2.1.2.7, RHEA:10067] synonym: "2-methylserine hydroxymethyltransferase activity" EXACT [EC:2.1.2.7] synonym: "5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity" EXACT [EC:2.1.2.7] synonym: "D-alanine hydroxymethyltransferase activity" EXACT [] xref: EC:2.1.2.7 xref: KEGG:R01225 xref: MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN xref: RHEA:10067 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0050414 name: formimidoylaspartate deiminase activity namespace: molecular_function def: "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3." [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN] synonym: "formiminoaspartate deiminase activity" EXACT [] synonym: "N-formimidoyl-L-aspartate iminohydrolase activity" EXACT [EC:3.5.3.5] xref: EC:3.5.3.5 xref: MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0050415 name: formimidoylglutamase activity namespace: molecular_function def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide." [EC:3.5.3.8, RHEA:22495] subset: gosubset_prok synonym: "formiminoglutamase activity" EXACT [] synonym: "formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8] synonym: "N-formimidoyl-L-glutamate formimidoylhydrolase activity" EXACT [EC:3.5.3.8] synonym: "N-formimino-L-glutamate formiminohydrolase activity" EXACT [EC:3.5.3.8] synonym: "N-formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8] xref: EC:3.5.3.8 xref: KEGG:R02285 xref: MetaCyc:FORMIMINOGLUTAMASE-RXN xref: RHEA:22495 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0050416 name: formimidoylglutamate deiminase activity namespace: molecular_function def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3." [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN] subset: gosubset_prok synonym: "formiminoglutamate deiminase activity" EXACT [] synonym: "formiminoglutamic iminohydrolase activity" EXACT [EC:3.5.3.13] synonym: "N-formimidoyl-L-glutamate iminohydrolase activity" EXACT [EC:3.5.3.13] xref: EC:3.5.3.13 xref: MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0050417 name: glutamin-(asparagin-)ase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate." [EC:3.5.1.38, MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN] subset: gosubset_prok synonym: "glutaminase-(asparagin-)ase activity" EXACT [] synonym: "glutaminase-asparaginase activity" EXACT [EC:3.5.1.38] synonym: "L-ASNase/L-GLNase activity" EXACT [EC:3.5.1.38] synonym: "L-asparagine/L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.38] synonym: "L-glutamine(L-asparagine) amidohydrolase activity" EXACT [EC:3.5.1.38] xref: EC:3.5.1.38 xref: MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050418 name: hydroxylamine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor." [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN] subset: gosubset_prok synonym: "ammonia:(acceptor) oxidoreductase activity" EXACT [EC:1.7.99.1] synonym: "ammonia:acceptor oxidoreductase activity" EXACT [EC:1.7.99.1] synonym: "hydroxylamine (acceptor) reductase activity" EXACT [EC:1.7.99.1] xref: EC:1.7.99.1 xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0050419 name: hydroxymandelonitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate." [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN] synonym: "(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.11] synonym: "(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity" EXACT [EC:4.1.2.11] synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.11] synonym: "sorghum hydroxynitrile lyase activity" EXACT [EC:4.1.2.11] xref: EC:4.1.2.11 xref: MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN is_a: GO:0047606 ! hydroxynitrilase activity [Term] id: GO:0050420 name: maltose synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate." [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN] synonym: "alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)" EXACT [EC:2.4.1.139] xref: EC:2.4.1.139 xref: MetaCyc:MALTOSE-SYNTHASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050421 name: nitrite reductase (NO-forming) activity namespace: molecular_function alt_id: GO:0016666 def: "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+." [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN] comment: Note that EC:1.7.99.3 was merged into this term. subset: gosubset_prok synonym: "[nitrite reductase (cytochrome)]" RELATED [EC:1.7.2.1] synonym: "cd-cytochrome nitrite reductase activity" NARROW [EC:1.7.2.1] synonym: "cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity" NARROW [EC:1.7.2.1] synonym: "cytochrome c-551:O2, NO2+ oxidoreductase activity" EXACT [EC:1.7.2.1] synonym: "cytochrome cd activity" NARROW [EC:1.7.2.1] synonym: "cytochrome cd1 activity" NARROW [EC:1.7.2.1] synonym: "methyl viologen-nitrite reductase activity" NARROW [EC:1.7.2.1] synonym: "nitric-oxide:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.1] synonym: "nitrite reductase (cytochrome) activity" EXACT [] synonym: "nitrite reductase (cytochrome; NO-forming) activity" EXACT [EC:1.7.2.1] synonym: "nitrite reductase activity" EXACT [] synonym: "Pseudomonas cytochrome oxidase activity" NARROW [EC:1.7.2.1] xref: EC:1.7.2.1 xref: MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: GO:0050422 name: strictosidine beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = D-glucose + strictosidine aglycone." [EC:3.2.1.105, RHEA:12920] synonym: "strictosidine b-glucosidase activity" EXACT [] synonym: "strictosidine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.105] xref: EC:3.2.1.105 xref: KEGG:R03820 xref: MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN xref: RHEA:12920 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050423 name: thiamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2." [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN] synonym: "thiamin dehydrogenase activity" EXACT [EC:1.1.3.23] synonym: "thiamin oxidase activity" EXACT [GOC:curators] synonym: "thiamin:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23] synonym: "thiamine dehydrogenase activity" EXACT [EC:1.1.3.23] synonym: "thiamine:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23] xref: EC:1.1.3.23 xref: MetaCyc:THIAMIN-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050424 name: alanine carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "N-benzoyl-L-alanine-amidohydrolase activity" EXACT [EC:3.4.17.6] xref: EC:3.4.17.6 xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0050425 name: carboxypeptidase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2] synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" EXACT [EC:3.4.17.2] synonym: "protaminase activity" RELATED [EC:3.4.17.2] synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2] xref: EC:3.4.17.2 xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0050426 name: peptidyl-glycinamidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [EC:3.4.19.2, MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "carboxamidopeptidase activity" EXACT [EC:3.4.19.2] synonym: "carboxyamidase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl amino acid amide hydrolase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl carboxy-amidase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl carboxyamidase activity" EXACT [EC:3.4.19.2] xref: EC:3.4.19.2 xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN is_obsolete: true replaced_by: GO:0008242 [Term] id: GO:0050427 name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "3'-phosphoadenosine 5'-phosphosulfate metabolism" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolic process" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolism" EXACT [] synonym: "3'-phosphoadenylyl-sulfate metabolic process" EXACT [] synonym: "3'-phosphoadenylyl-sulfate metabolism" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolic process" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolism" EXACT [] synonym: "PAPS metabolic process" EXACT [] synonym: "PAPS metabolism" EXACT [] synonym: "phosphoadenosine phosphosulfate metabolic process" EXACT [] synonym: "phosphoadenosine phosphosulfate metabolism" EXACT [] xref: MetaCyc:PWY-5340 xref: Reactome:1235933 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1253293 "Cytosolic sulfonation of small molecules" xref: Reactome:1263207 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1280230 "Cytosolic sulfonation of small molecules" xref: Reactome:1287770 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1299184 "Cytosolic sulfonation of small molecules" xref: Reactome:1309587 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1326806 "Cytosolic sulfonation of small molecules" xref: Reactome:1336532 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1353014 "Cytosolic sulfonation of small molecules" xref: Reactome:1360455 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1373112 "Cytosolic sulfonation of small molecules" xref: Reactome:1381257 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1393224 "Cytosolic sulfonation of small molecules" xref: Reactome:1402545 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1417617 "Cytosolic sulfonation of small molecules" xref: Reactome:1430618 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1450819 "Cytosolic sulfonation of small molecules" xref: Reactome:1459159 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1471229 "Cytosolic sulfonation of small molecules" xref: Reactome:1476634 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1483219 "Cytosolic sulfonation of small molecules" xref: Reactome:1496910 "Cytosolic sulfonation of small molecules" xref: Reactome:1514299 "Cytosolic sulfonation of small molecules" xref: Reactome:1518144 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:1521173 "Cytosolic sulfonation of small molecules" xref: Reactome:1526909 "Cytosolic sulfonation of small molecules" xref: Reactome:1532646 "Cytosolic sulfonation of small molecules" xref: Reactome:156584 "Cytosolic sulfonation of small molecules" xref: Reactome:176606 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process [Term] id: GO:0050428 name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "3'-phosphoadenosine 5'-phosphosulfate anabolism" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulfate biosynthesis" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulfate formation" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulfate synthesis" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthesis" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthetic process" EXACT [] synonym: "3'-phosphoadenylyl-sulfate biosynthesis" EXACT [] synonym: "3'-phosphoadenylyl-sulfate biosynthetic process" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthesis" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthetic process" EXACT [] synonym: "PAPS biosynthesis" EXACT [] synonym: "PAPS biosynthetic process" EXACT [] synonym: "phosphoadenosine phosphosulfate biosynthesis" EXACT [] synonym: "phosphoadenosine phosphosulfate biosynthetic process" EXACT [] xref: Reactome:1253405 "Formation of PAPS" xref: Reactome:1280342 "Formation of PAPS" xref: Reactome:1299183 "Formation of PAPS" xref: Reactome:1326922 "Formation of PAPS" xref: Reactome:1353013 "Formation of PAPS" xref: Reactome:1373209 "Formation of PAPS" xref: Reactome:1393223 "Formation of PAPS" xref: Reactome:1417719 "Formation of PAPS" xref: Reactome:1450818 "Formation of PAPS" xref: Reactome:1471228 "Formation of PAPS" xref: Reactome:1483218 "Formation of PAPS" xref: Reactome:1496909 "Formation of PAPS" xref: Reactome:1514298 "Formation of PAPS" xref: Reactome:1526908 "Formation of PAPS" xref: Reactome:1532645 "Formation of PAPS" xref: Reactome:174362 "Formation of PAPS" is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process is_a: GO:0050427 ! 3'-phosphoadenosine 5'-phosphosulfate metabolic process [Term] id: GO:0050429 name: calcium-dependent phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+." [EC:3.1.4.3] is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0050430 name: syntaxin-6 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-6." [GOC:ai] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0050431 name: transforming growth factor beta binding namespace: molecular_function def: "Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "TGF-beta binding" EXACT [] synonym: "TGFbeta binding" EXACT [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0050432 name: catecholamine secretion namespace: biological_process def: "The regulated release of catecholamines by a cell or group of cells. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef] is_a: GO:0032940 ! secretion by cell is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0050433 name: regulation of catecholamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051952 ! regulation of amine transport is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0050432 ! catecholamine secretion [Term] id: GO:0050434 name: positive regulation of viral transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of viral transcription." [GOC:ai] synonym: "activation of viral transcription" NARROW [] synonym: "stimulation of viral transcription" NARROW [] synonym: "up regulation of viral transcription" EXACT [] synonym: "up-regulation of viral transcription" EXACT [] synonym: "upregulation of viral transcription" EXACT [] xref: Reactome:167246 "Tat-mediated elongation of the HIV-1 transcript" is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046782 ! regulation of viral transcription is_a: GO:0048524 ! positive regulation of viral reproduction is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0019083 ! viral transcription [Term] id: GO:0050435 name: beta-amyloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai] subset: gosubset_prok synonym: "beta-amyloid metabolism" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0050436 name: microfibril binding namespace: molecular_function def: "Interacting selectively and non-covalently with a microfibril, any small fibril occurring in biological material." [GOC:ai] comment: See also the cellular component term 'microfibril ; GO:0001527'. is_a: GO:0005488 ! binding [Term] id: GO:0050437 name: (-)-endo-fenchol synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (-)-endo-fenchol + diphosphate." [EC:4.2.3.10, RHEA:20568] synonym: "(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10] synonym: "geranyl pyrophosphate:(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10] synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]" RELATED [EC:4.2.3.10] xref: EC:4.2.3.10 xref: KEGG:R02004 xref: MetaCyc:4.2.3.10-RXN xref: RHEA:20568 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050438 name: 2-ethylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H(2)O = (R)-2-ethylmalate + CoA + H(+)." [EC:2.3.3.6, RHEA:23043] synonym: "(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.6] synonym: "2-ethylmalate-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.6] synonym: "acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.6] synonym: "propylmalate synthase activity" EXACT [EC:2.3.3.6] synonym: "propylmalic synthase activity" EXACT [EC:2.3.3.6] xref: EC:2.3.3.6 xref: KEGG:R00998 xref: MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN xref: RHEA:23043 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050439 name: 2-hydroxy-3-oxoadipate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2)." [EC:2.2.1.5, RHEA:14344] synonym: "2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity" EXACT [EC:2.2.1.5] synonym: "2-hydroxy-3-oxoadipate synthetase activity" EXACT [EC:2.2.1.5] synonym: "2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.5] synonym: "alpha-ketoglutaric-glyoxylic carboligase activity" EXACT [EC:2.2.1.5] synonym: "oxoglutarate: glyoxylate carboligase activity" EXACT [EC:2.2.1.5] synonym: "oxoglutarate:glyoxylate carboligase activity" EXACT [EC:2.2.1.5] xref: EC:2.2.1.5 xref: KEGG:R00474 xref: MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN xref: RHEA:14344 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0050440 name: 2-methylcitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+)." [EC:2.3.3.5, RHEA:23783] subset: gosubset_prok synonym: "2-methylcitrate oxaloacetate-lyase activity" EXACT [EC:2.3.3.5] synonym: "MCS activity" EXACT [EC:2.3.3.5] synonym: "methylcitrate synthase activity" EXACT [EC:2.3.3.5] synonym: "methylcitrate synthetase activity" EXACT [EC:2.3.3.5] synonym: "propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)" EXACT [EC:2.3.3.5] xref: EC:2.3.3.5 xref: KEGG:R00931 xref: MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN xref: RHEA:23783 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050441 name: 3-ethylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + glyoxylate + H(2)O = 3-ethylmalate + CoA + H(+)." [EC:2.3.3.7, RHEA:10503] synonym: "2-ethyl-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.7] synonym: "3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity" EXACT [EC:2.3.3.7] synonym: "butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)" EXACT [EC:2.3.3.7] xref: EC:2.3.3.7 xref: KEGG:R01180 xref: MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN xref: RHEA:10503 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050442 name: 3-propylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + H(2)O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)." [EC:2.3.3.12, RHEA:14460] synonym: "3-(n-propyl)-malate synthase activity" EXACT [EC:2.3.3.12] synonym: "3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity" EXACT [EC:2.3.3.12] synonym: "beta-n-propylmalate synthase activity" EXACT [EC:2.3.3.12] synonym: "n-propylmalate synthase activity" EXACT [EC:2.3.3.12] synonym: "N-propylmalate synthase activity" EXACT [EC:2.3.3.12] synonym: "pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)" EXACT [EC:2.3.3.12] xref: EC:2.3.3.12 xref: KEGG:R03040 xref: MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN xref: RHEA:14460 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050444 name: aquacobalamin reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+." [EC:1.16.1.5, MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN] synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) activity" EXACT [EC:1.16.1.5] synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.16.1.5] synonym: "cob(II)alamin:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.5] synonym: "NADPH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.5] synonym: "NADPH2:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5] synonym: "NADPH:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5] xref: EC:1.16.1.5 xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0050445 name: asparagusate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD(+) = asparagusate + H(+) + NADH." [EC:1.8.1.11, RHEA:14884] synonym: "3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.11] synonym: "asparagusate dehydrogenase activity" EXACT [EC:1.8.1.11] synonym: "asparagusate reductase (NADH) activity" EXACT [] synonym: "asparagusate reductase (NADH2)" EXACT [EC:1.8.1.11] synonym: "asparagusic dehydrogenase activity" EXACT [EC:1.8.1.11] synonym: "NADH2:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11] synonym: "NADH:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11] xref: EC:1.8.1.11 xref: KEGG:R03761 xref: MetaCyc:ASPARAGUSATE-REDUCTASE-NADH-RXN xref: RHEA:14884 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0050446 name: azobenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+." [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN] synonym: "azo reductase activity" BROAD [EC:1.7.1.6] synonym: "azo-dye reductase activity" BROAD [EC:1.7.1.6] synonym: "azoreductase activity" BROAD [EC:1.7.1.6] synonym: "dibromopropylaminophenylazobenzoic azoreductase activity" EXACT [EC:1.7.1.6] synonym: "dimethylaminobenzene reductase activity" EXACT [EC:1.7.1.6] synonym: "methyl red azoreductase activity" NARROW [EC:1.7.1.6] synonym: "N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "N,N-dimethyl-4-phenylazoaniline azoreductase activity" EXACT [EC:1.7.1.6] synonym: "NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "NADPH-dependent azoreductase activity" BROAD [EC:1.7.1.6] synonym: "NADPH2-dependent azoreductase activity" EXACT [EC:1.7.1.6] synonym: "NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "NADPH:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "NC-reductase activity" NARROW [EC:1.7.1.6] synonym: "new coccine (NC)-reductase" RELATED [EC:1.7.1.6] synonym: "New coccine (NC)-reductase activity" NARROW [EC:1.7.1.6] synonym: "nicotinamide adenine dinucleotide (phosphate) azoreductase activity" EXACT [EC:1.7.1.6] synonym: "orange I azoreductase activity" NARROW [EC:1.7.1.6] synonym: "orange II azoreductase activity" NARROW [EC:1.7.1.6] synonym: "p-aminoazobenzene reductase activity" EXACT [EC:1.7.1.6] synonym: "p-dimethylaminoazobenzene azoreductase activity" EXACT [EC:1.7.1.6] xref: EC:1.7.1.6 xref: MetaCyc:AZOBENZENE-REDUCTASE-RXN xref: UM-BBD_reactionID:r0808 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0050447 name: zeatin 9-aminocarboxyethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H(+)." [EC:2.5.1.50, RHEA:17336] synonym: "3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50] synonym: "beta-(9-cytokinin)-alanine synthase activity" EXACT [] synonym: "beta-(9-cytokinin)alanine synthase activity" EXACT [EC:2.5.1.50] synonym: "lupinate synthetase activity" EXACT [EC:2.5.1.50] synonym: "lupinic acid synthase activity" EXACT [EC:2.5.1.50] synonym: "lupinic acid synthetase activity" EXACT [EC:2.5.1.50] synonym: "O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity" EXACT [EC:2.5.1.50] synonym: "O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)" EXACT [EC:2.5.1.50] synonym: "O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50] xref: EC:2.5.1.50 xref: KEGG:R03133 xref: MetaCyc:BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN xref: RHEA:17336 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050448 name: beta-cyclopiazonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2)." [EC:1.21.99.1, RHEA:14526] synonym: "b-cyclopiazonate dehydrogenase activity" EXACT [] synonym: "beta-cyclopiazonate oxidocyclase activity" EXACT [EC:1.21.99.1] synonym: "beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1] synonym: "beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1] synonym: "beta-cyclopiazonic oxidocyclase activity" EXACT [EC:1.21.99.1] xref: EC:1.21.99.1 xref: KEGG:R04080 xref: MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN xref: RHEA:14526 is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond [Term] id: GO:0050449 name: casbene synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate." [EC:4.2.3.8, RHEA:14904] synonym: "casbene synthetase activity" EXACT [EC:4.2.3.8] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.8] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)" EXACT [EC:4.2.3.8] xref: EC:4.2.3.8 xref: KEGG:R02064 xref: MetaCyc:CASBENE-SYNTHASE-RXN xref: RHEA:14904 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0050450 name: citrate (Re)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group." [EC:2.3.3.3, ISBN:0121227073, MetaCyc:CITRATE-RE-SYNTHASE-RXN] synonym: "(R)-citrate synthase activity" EXACT [EC:2.3.3.3] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]" RELATED [EC:2.3.3.3] synonym: "citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.3] synonym: "citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]" RELATED [EC:2.3.3.3] synonym: "Re-citrate-synthase activity" EXACT [EC:2.3.3.3] xref: EC:2.3.3.3 xref: MetaCyc:CITRATE-RE-SYNTHASE-RXN is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050451 name: CoA-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+." [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN] synonym: "CoA-disulfide reductase (NAD(P)H) activity" RELATED [EC:1.8.1.14] synonym: "CoA-disulfide reductase (NADH) activity" EXACT [] synonym: "CoA-disulfide reductase (NADH2)" EXACT [EC:1.8.1.14] synonym: "CoA-disulfide reductase [NAD(P)H]" RELATED [EC:1.8.1.14] synonym: "CoA-disulphide reductase activity" EXACT [] synonym: "CoA:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "CoA:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "CoADR activity" EXACT [EC:1.8.1.14] synonym: "coenzyme A disulfide reductase activity" EXACT [EC:1.8.1.14] synonym: "NADH2:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "NADH:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] xref: EC:1.8.1.14 xref: MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0050452 name: CoA-glutathione reductase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+." [EC:1.8.1.10, MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN] synonym: "CoA-glutathione reductase (NADPH) activity" EXACT [] synonym: "coenzyme A disulfide-glutathione reductase activity" EXACT [EC:1.8.1.10] synonym: "coenzyme A glutathione disulfide reductase activity" EXACT [EC:1.8.1.10] synonym: "glutathione:NADP+ oxidoreductase (CoA-acylating)" EXACT [EC:1.8.1.10] synonym: "NADPH-dependent coenzyme A-SS-glutathione reductase activity" EXACT [EC:1.8.1.10] synonym: "NADPH2:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10] synonym: "NADPH:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10] xref: EC:1.8.1.10 xref: MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0050453 name: cob(II)alamin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH." [EC:1.16.1.4, RHEA:17484] synonym: "B(12r) reductase activity" EXACT [EC:1.16.1.4] synonym: "B12r reductase activity" EXACT [EC:1.16.1.4] synonym: "cob(I)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.4] synonym: "NADH2:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4] synonym: "NADH:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4] synonym: "vitamin B(12r) reductase activity" EXACT [EC:1.16.1.4] synonym: "vitamin B12 reductase activity" EXACT [] synonym: "vitamin B12 reduction" RELATED [] synonym: "vitamin B12r reductase activity" EXACT [EC:1.16.1.4] xref: EC:1.16.1.4 xref: KEGG:R00099 xref: MetaCyc:COBIIALAMIN-REDUCTASE-RXN xref: RHEA:17484 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0050454 name: coenzyme F420 hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme F420 + H(2) + H(+) = reduced coenzyme F(420)." [EC:1.12.98.1, RHEA:23763] subset: gosubset_prok synonym: "8-hydroxy-5-deazaflavin-reducing hydrogenase activity" EXACT [EC:1.12.98.1] synonym: "coenzyme F420-dependent hydrogenase activity" EXACT [EC:1.12.98.1] synonym: "F420-reducing hydrogenase activity" EXACT [EC:1.12.98.1] synonym: "hydrogen:coenzyme F420 oxidoreductase activity" EXACT [EC:1.12.98.1] xref: EC:1.12.98.1 xref: KEGG:R03025 xref: MetaCyc:COENZYME-F420-HYDROGENASE-RXN xref: RHEA:23763 is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors [Term] id: GO:0050455 name: columbamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 columbamine + O(2) = 2 berberine + 2 H(2)O." [EC:1.21.3.2, RHEA:23567] synonym: "berberine synthase activity" EXACT [EC:1.21.3.2] synonym: "columbamine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.2] xref: EC:1.21.3.2 xref: KEGG:R00044 xref: MetaCyc:COLUMBAMINE-OXIDASE-RXN xref: RHEA:23567 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0050456 name: cystine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-cysteine + NAD(+) = L-cystine + H(+) + NADH." [EC:1.8.1.6, RHEA:20600] subset: gosubset_prok synonym: "cystine reductase (NADH) activity" EXACT [EC:1.8.1.6] synonym: "cystine reductase (NADH2)" EXACT [EC:1.8.1.6] synonym: "L-cysteine:NAD+ oxidoreductase" EXACT [EC:1.8.1.6] synonym: "NADH-dependent cystine reductase activity" EXACT [EC:1.8.1.6] synonym: "NADH2:L-cystine oxidoreductase" EXACT [EC:1.8.1.6] synonym: "NADH:L-cystine oxidoreductase activity" EXACT [EC:1.8.1.6] xref: EC:1.8.1.6 xref: KEGG:R00892 xref: MetaCyc:CYSTINE-REDUCTASE-NADH-RXN xref: RHEA:20600 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0050457 name: decylcitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)." [EC:2.3.3.2, RHEA:16608] synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.2] synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)" EXACT [EC:2.3.3.2] synonym: "2-decylcitrate synthase activity" EXACT [EC:2.3.3.2] synonym: "dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.2] xref: EC:2.3.3.2 xref: KEGG:R03735 xref: MetaCyc:DECYLCITRATE-SYNTHASE-RXN xref: RHEA:16608 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050458 name: decylhomocitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + H(2)O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)." [EC:2.3.3.4, RHEA:10367] synonym: "2-decylhomocitrate synthase activity" EXACT [EC:2.3.3.4] synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.4] synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)" EXACT [EC:2.3.3.4] synonym: "dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.4] xref: EC:2.3.3.4 xref: KEGG:R03859 xref: MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN xref: RHEA:10367 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050459 name: ethanolamine-phosphate phospho-lyase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate." [EC:4.2.3.2, RHEA:17892] synonym: "amino alcohol O-phosphate phospholyase activity" BROAD [EC:4.2.3.2] synonym: "ethanolamine-phosphate phospho-lyase (deaminating)" EXACT [EC:4.2.3.2] synonym: "ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)" EXACT [EC:4.2.3.2] synonym: "O-phosphoethanolamine-phospholyase activity" EXACT [EC:4.2.3.2] synonym: "O-phosphorylethanol-amine phospho-lyase activity" EXACT [EC:4.2.3.2] xref: EC:4.2.3.2 xref: KEGG:R00748 xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN xref: RHEA:17892 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050460 name: hydroxylamine reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+." [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN] synonym: "ammonium dehydrogenase activity" EXACT [EC:1.7.1.10] synonym: "ammonium:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.10] synonym: "hydroxylamine reductase (NADH2)" EXACT [EC:1.7.1.10] synonym: "N-hydroxy amine reductase activity" EXACT [EC:1.7.1.10] synonym: "NADH-hydroxylamine reductase activity" EXACT [EC:1.7.1.10] synonym: "NADH2:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10] synonym: "NADH:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10] xref: EC:1.7.1.10 xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0050461 name: L-mimosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate." [EC:2.5.1.52, RHEA:12696] synonym: "3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity" EXACT [EC:2.5.1.52] synonym: "O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)" EXACT [EC:2.5.1.52] synonym: "O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52] xref: EC:2.5.1.52 xref: KEGG:R04091 xref: MetaCyc:RXN-7461 xref: RHEA:12696 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050462 name: N-acetylneuraminate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate." [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN] synonym: "(NANA)condensing enzyme activity" EXACT [EC:2.5.1.56] synonym: "N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.56] synonym: "N-acetylneuraminic acid synthase activity" EXACT [EC:2.5.1.56] synonym: "NeuAc synthase activity" EXACT [EC:2.5.1.56] synonym: "phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.56] xref: EC:2.5.1.56 xref: MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050463 name: nitrate reductase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+." [EC:1.7.1.2, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN] synonym: "assimilatory NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2] synonym: "assimilatory nitrate reductase activity" RELATED [EC:1.7.1.2] synonym: "NAD(P)H bispecific nitrate reductase activity" EXACT [EC:1.7.1.2] synonym: "NAD(P)H-nitrate reductase activity" EXACT [EC:1.7.1.2] synonym: "NAD(P)H2:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2] synonym: "NAD(P)H:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2] synonym: "nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.2] synonym: "nitrate reductase [NAD(P)H2]" RELATED [EC:1.7.1.2] synonym: "nitrate reductase NAD(P)H activity" EXACT [EC:1.7.1.2] synonym: "nitrite:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.2] xref: EC:1.7.1.2 is_a: GO:0008940 ! nitrate reductase activity is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0050464 name: nitrate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+." [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN] synonym: "assimilatory NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.3] synonym: "assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "NADPH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.3] synonym: "NADPH:nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "nitrate reductase (NADPH(2)) activity" EXACT [EC:1.7.1.3] synonym: "nitrate reductase (NADPH2)" EXACT [EC:1.7.1.3] synonym: "nitrite:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.3] synonym: "triphosphopyridine nucleotide-nitrate reductase activity" EXACT [EC:1.7.1.3] xref: EC:1.7.1.3 xref: MetaCyc:NITRATE-REDUCTASE-NADPH-RXN is_a: GO:0008940 ! nitrate reductase activity is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0050465 name: nitroquinoline-N-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+." [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN] synonym: "4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.9] synonym: "4-nitroquinoline 1-oxide reductase activity" EXACT [EC:1.7.1.9] synonym: "4NQO reductase activity" EXACT [EC:1.7.1.9] synonym: "NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9] synonym: "NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9] xref: EC:1.7.1.9 xref: MetaCyc:1.7.1.9-RXN is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0050466 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0046992 [Term] id: GO:0050467 name: pentalenene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene." [EC:4.2.3.7, RHEA:18084] subset: gosubset_prok synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7] synonym: "2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7] synonym: "pentalenene synthetase activity" EXACT [EC:4.2.3.7] xref: EC:4.2.3.7 xref: KEGG:R02305 xref: MetaCyc:PENTALENENE-SYNTHASE-RXN xref: RHEA:18084 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0050468 name: reticuline oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2) + H(+)." [EC:1.21.3.3, RHEA:19888] synonym: "(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)" EXACT [EC:1.21.3.3] synonym: "BBE" RELATED [EC:1.21.3.3] synonym: "berberine bridge enzyme activity" EXACT [EC:1.21.3.3] synonym: "berberine-bridge-forming enzyme activity" EXACT [EC:1.21.3.3] synonym: "tetrahydroprotoberberine synthase activity" EXACT [EC:1.21.3.3] xref: EC:1.21.3.3 xref: KEGG:R03831 xref: MetaCyc:RETICULINE-OXIDASE-RXN xref: RHEA:19888 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0050469 name: sabinene-hydrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = diphosphate + sabinene hydrate." [EC:4.2.3.11, RHEA:19568] synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)" EXACT [EC:4.2.3.11] synonym: "sabinene hydrate cyclase activity" EXACT [EC:4.2.3.11] xref: EC:4.2.3.11 xref: KEGG:R02006 xref: MetaCyc:4.2.3.11-RXN xref: RHEA:19568 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050470 name: trimethylamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein." [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN] subset: gosubset_prok synonym: "TMADh activity" EXACT [EC:1.5.8.2] synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" EXACT [EC:1.5.8.2] xref: EC:1.5.8.2 xref: MetaCyc:1.5.8.2-RXN xref: UM-BBD_enzymeID:e0854 is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor [Term] id: GO:0050471 name: uracilylalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate." [EC:2.5.1.53, MetaCyc:URACILYLALANINE-SYNTHASE-RXN] synonym: "3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53] synonym: "isowillardiine synthase activity" EXACT [EC:2.5.1.53] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity" EXACT [EC:2.5.1.53] synonym: "O3-acetyl-L-serine acetate-lyase (adding uracil)" EXACT [EC:2.5.1.53] synonym: "O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53] synonym: "willardiine synthase activity" EXACT [EC:2.5.1.53] synonym: "Willardiine synthase activity" EXACT [EC:2.5.1.53] xref: EC:2.5.1.53 xref: MetaCyc:URACILYLALANINE-SYNTHASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050472 name: zeatin reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin." [EC:1.3.1.69, RHEA:12760] synonym: "dihydrozeatin:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.69] xref: EC:1.3.1.69 xref: KEGG:R05702 xref: MetaCyc:ZEATIN-REDUCTASE-RXN xref: RHEA:12760 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050473 name: arachidonate 15-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate." [EC:1.13.11.33] subset: gosubset_prok synonym: "15-lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "arachidonate omega(6) lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "arachidonate omega6 lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "arachidonate:oxygen 15-oxidoreductase activity" EXACT [EC:1.13.11.33] synonym: "linoleic acid omega6-lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "omega6 lipoxygenase activity" EXACT [EC:1.13.11.33] xref: EC:1.13.11.33 xref: MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050474 name: (S)-norcoclaurine synthase activity namespace: molecular_function alt_id: GO:0050475 def: "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O." [EC:4.2.1.78] synonym: "(S)-norlaudanosoline synthase activity" EXACT [EC:4.2.1.78] synonym: "4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)" EXACT [EC:4.2.1.78] synonym: "4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]" RELATED [EC:4.2.1.78] xref: EC:4.2.1.78 xref: MetaCyc:S-NORLAUDANOSOLINE-SYNTHASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050476 name: acetylenedicarboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate." [EC:4.1.1.78] synonym: "acetylenedicarboxylate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.78] synonym: "acetylenedicarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.78] synonym: "acetylenedicarboxylate hydrase activity" EXACT [EC:4.1.1.78] synonym: "acetylenedicarboxylate hydratase activity" EXACT [EC:4.1.1.78] xref: EC:4.1.1.78 xref: MetaCyc:4.1.1.78-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050477 name: acyl-lysine deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate." [EC:3.5.1.17] synonym: "6-N-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17] synonym: "epsilon-lysine acylase activity" EXACT [EC:3.5.1.17] synonym: "N6-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17] xref: EC:3.5.1.17 xref: MetaCyc:ACYL-LYSINE-DEACYLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050478 name: anthranilate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + anthranilate + O(2) = 3-hydroxyanthranilate + 7,8-dihydrobiopterin + H(2)O." [EC:1.14.16.3, RHEA:21171] synonym: "anthranilate 3-hydroxylase activity" EXACT [] synonym: "anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.3] synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.16.3] synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.16.3] xref: EC:1.14.16.3 xref: KEGG:R01816 xref: MetaCyc:1.14.16.3-RXN xref: RHEA:21171 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050479 name: glyceryl-ether monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN] synonym: "1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity" EXACT [EC:1.14.16.5] synonym: "alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5] synonym: "glyceryl ether oxygenase activity" EXACT [EC:1.14.16.5] synonym: "glyceryl etherase activity" EXACT [EC:1.14.16.5] synonym: "glyceryl-ether cleaving enzyme activity" EXACT [EC:1.14.16.5] synonym: "O-alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5] xref: EC:1.14.16.5 xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050480 name: imidazolonepropionase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+)." [EC:3.5.2.7, RHEA:23663] subset: gosubset_prok synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity" EXACT [EC:3.5.2.7] synonym: "4(5)-imidazolone-5(4)-propionic acid hydrolase activity" EXACT [EC:3.5.2.7] synonym: "imidazolone propionic acid hydrolase activity" EXACT [EC:3.5.2.7] synonym: "imidazolone-5-propionate hydrolase activity" EXACT [EC:3.5.2.7] xref: EC:3.5.2.7 xref: KEGG:R02288 xref: MetaCyc:IMIDAZOLONEPROPIONASE-RXN xref: RHEA:23663 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0050481 name: mandelate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O(2) = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H(2)O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate." [EC:1.14.16.6, RHEA:21719] synonym: "(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.6] synonym: "L-mandelate 4-hydroxylase activity" EXACT [] synonym: "mandelic acid 4-hydroxylase activity" EXACT [EC:1.14.16.6] xref: EC:1.14.16.6 xref: KEGG:R03794 xref: MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN xref: RHEA:21719 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050482 name: arachidonic acid secretion namespace: biological_process def: "The controlled release of arachidonic acid from a cell or group of cells." [GOC:ai] is_a: GO:0015909 ! long-chain fatty acid transport is_a: GO:0032309 ! icosanoid secretion is_a: GO:0046717 ! acid secretion [Term] id: GO:0050483 name: IMP 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai] synonym: "IMP 5' nucleotidase activity" EXACT [] synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED [] xref: MetaCyc:RXN-7607 is_a: GO:0008253 ! 5'-nucleotidase activity [Term] id: GO:0050484 name: GMP 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai] synonym: "GMP 5' nucleotidase activity" EXACT [] synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED [] xref: MetaCyc:RXN-7609 is_a: GO:0008253 ! 5'-nucleotidase activity [Term] id: GO:0050485 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor" EXACT [] xref: EC:1.21.4 is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond [Term] id: GO:0050486 name: intramolecular transferase activity, transferring hydroxy groups namespace: molecular_function def: "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.4.4 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0050487 name: sulfoacetaldehyde acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde." [EC:2.3.3.15, RHEA:24207] comment: Note that the enzyme sulfoacetaldehyde acetyltransferase also has sulfoacetaldehyde lyase activity (GO:0050312). subset: gosubset_prok synonym: "acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)" EXACT [EC:2.3.3.15] synonym: "sulphoacetaldehyde acetyltransferase activity" EXACT [] xref: EC:2.3.3.15 xref: KEGG:R05651 xref: MetaCyc:RXN-2364 xref: RHEA:24207 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050488 name: ecdysteroid UDP-glucosyltransferase activity namespace: molecular_function alt_id: GO:0050489 def: "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid." [GOC:ai, PMID:10073711] synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED [] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050490 name: 1,4-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid." [EC:3.1.1.25, MetaCyc:14-LACTONASE-RXN] synonym: "1,4-lactone hydroxyacylhydrolase activity" EXACT [EC:3.1.1.25] synonym: "gamma-lactonase activity" EXACT [EC:3.1.1.25] xref: EC:3.1.1.25 xref: MetaCyc:14-LACTONASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050491 name: sulcatone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + sulcatol = H(+) + NADH + sulcatone." [EC:1.1.1.260, RHEA:24487] synonym: "sulcatol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.260] xref: EC:1.1.1.260 xref: KEGG:R05678 xref: MetaCyc:1.1.1.260-RXN xref: RHEA:24487 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050492 name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate." [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN] subset: gosubset_prok synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.261] xref: EC:1.1.1.261 xref: MetaCyc:1.1.1.261-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050493 name: GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0164] subset: gosubset_prok synonym: "GPI anchor anabolism via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0164 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0050494 name: GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0165] subset: gosubset_prok synonym: "GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] xref: RESID:AA0165 is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0042082 ! GSI anchor biosynthetic process [Term] id: GO:0050495 name: peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine." [RESID:AA0346] subset: gosubset_prok synonym: "peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine" EXACT [] xref: RESID:AA0346 is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0050496 name: peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine namespace: biological_process def: "The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide." [PMID:10411887, RESID:AA0347] subset: gosubset_prok synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine" EXACT [] xref: RESID:AA0340 is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0050497 name: transferase activity, transferring alkylthio groups namespace: molecular_function def: "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)." [GOC:ai] subset: gosubset_prok xref: EC:2.8.4 is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0050498 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated." [GOC:mah] subset: gosubset_prok xref: EC:1.14.20 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050499 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H." [GOC:mah] subset: gosubset_prok xref: EC:1.20.1 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0050500 name: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1,3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate." [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN] synonym: "1,3-b-galactosyl-N-acetylhexosamine phosphorylase activity" EXACT [] synonym: "beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" EXACT [EC:2.4.1.211] xref: EC:2.4.1.211 xref: MetaCyc:2.4.1.211-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0050501 name: hyaluronan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)](n) + 2n UDP." [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN] subset: gosubset_prok synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" EXACT [EC:2.4.1.212] synonym: "HAS activity" EXACT [EC:2.4.1.212] synonym: "seHAS" RELATED [EC:2.4.1.212] synonym: "spHAS" RELATED [EC:2.4.1.212] xref: EC:2.4.1.212 xref: MetaCyc:2.4.1.212-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050502 name: cis-zeatin O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H(+) + UDP." [EC:2.4.1.215, RHEA:20684] synonym: "cis-zeatin O-b-D-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215] synonym: "UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215] xref: EC:2.4.1.215 xref: KEGG:R07260 xref: MetaCyc:RXN-4735 xref: RHEA:20684 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050503 name: trehalose 6-phosphate phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate." [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN] subset: gosubset_prok synonym: "trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.216] xref: EC:2.4.1.216 xref: MetaCyc:2.4.1.216-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0050504 name: mannosyl-3-phosphoglycerate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)." [EC:2.4.1.217, RHEA:13540] subset: gosubset_prok synonym: "GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.217] synonym: "MPG synthase activity" EXACT [EC:2.4.1.217] xref: EC:2.4.1.217 xref: KEGG:R05768 xref: MetaCyc:2.4.1.217-RXN xref: RHEA:13540 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050505 name: hydroquinone glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydroquinone + UDP-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP." [EC:2.4.1.218, RHEA:12563] synonym: "arbutin synthase activity" EXACT [EC:2.4.1.218] synonym: "hydroquinone:O-glucosyltransferase activity" EXACT [EC:2.4.1.218] synonym: "UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218] synonym: "UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218] xref: EC:2.4.1.218 xref: KEGG:R05769 xref: MetaCyc:2.4.1.218-RXN xref: RHEA:12563 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050506 name: vomilenine glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucose + vomilenine = H(+) + raucaffricine + UDP." [EC:2.4.1.219, RHEA:19388] synonym: "UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] synonym: "UDPG:vomilenine 21-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] synonym: "UDPG:vomilenine 21beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] synonym: "vomilenine-glucosyltransferase activity" EXACT [EC:2.4.1.219] xref: EC:2.4.1.219 xref: KEGG:R05882 xref: MetaCyc:2.4.1.219-RXN xref: RHEA:19388 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050507 name: indoxyl-UDPG glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indoxyl + UDP-D-glucose = H(+) + indican + UDP." [EC:2.4.1.220, RHEA:12007] synonym: "indoxyl-UDPG-glucosyltransferase activity" EXACT [EC:2.4.1.220] synonym: "UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.220] xref: EC:2.4.1.220 xref: KEGG:R06048 xref: MetaCyc:2.4.1.220-RXN xref: RHEA:12007 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050508 name: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN] synonym: "alpha-N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.224] synonym: "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224] xref: EC:2.4.1.224 xref: MetaCyc:2.4.1.224-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0050509 name: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN] synonym: "heparan glucuronyltransferase II activity" EXACT [EC:2.4.1.225] synonym: "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity" EXACT [] synonym: "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity" EXACT [EC:2.4.1.225] synonym: "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.225] xref: EC:2.4.1.225 xref: MetaCyc:2.4.1.225-RXN is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0050510 name: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN] synonym: "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.226] synonym: "chondroitin glucuronyltransferase II activity" EXACT [EC:2.4.1.226] synonym: "N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity" EXACT [] xref: EC:2.4.1.226 xref: MetaCyc:2.4.1.226-RXN is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0050511 name: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP." [EC:2.4.1.227, MetaCyc:2.4.1.227-RXN] comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227. subset: gosubset_prok synonym: "MurG transferase activity" RELATED [EC:2.4.1.227] synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity" EXACT [EC:2.4.1.227] synonym: "UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity" EXACT [EC:2.4.1.227] synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.227] synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT [] xref: EC:2.4.1.227 xref: MetaCyc:RXN-8976 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0050512 name: lactosylceramide 4-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN] synonym: "Gal-beta-1-4Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228] synonym: "galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228] synonym: "globotriaosylceramide/CD77 synthase activity" NARROW [EC:2.4.1.228] synonym: "histo-blood group P(k) UDP-galactose activity" NARROW [EC:2.4.1.228] synonym: "histo-blood group Pk UDP-galactose" RELATED [EC:2.4.1.228] synonym: "lactosylceramide 4-a-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.228] xref: EC:2.4.1.228 xref: MetaCyc:2.4.1.228-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0050513 name: glycoprotein 2-beta-D-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H(+) + UDP." [EC:2.4.2.38, RHEA:10615] synonym: "beta-1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38] synonym: "beta1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38] synonym: "glycoprotein 2-b-D-xylosyltransferase activity" EXACT [] xref: EC:2.4.2.38 xref: KEGG:R06016 xref: MetaCyc:2.4.2.38-RXN xref: RHEA:10615 is_a: GO:0035252 ! UDP-xylosyltransferase activity [Term] id: GO:0050514 name: homospermidine synthase (spermidine-specific) activity namespace: molecular_function def: "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine." [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN] synonym: "spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)" EXACT [EC:2.5.1.45] xref: EC:2.5.1.45 xref: MetaCyc:2.5.1.45-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050515 name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity namespace: molecular_function alt_id: GO:0008698 def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H(+)." [EC:2.7.1.148, RHEA:18440] subset: gosubset_prok synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity" EXACT [EC:2.7.1.148] synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity" EXACT [] synonym: "ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity" EXACT [EC:2.7.1.148] synonym: "CDP-ME kinase activity" EXACT [EC:2.7.1.148] synonym: "CMK activity" RELATED [EC:2.7.1.148] xref: EC:2.7.1.148 xref: KEGG:R05634 xref: MetaCyc:2.7.1.148-RXN xref: RHEA:18440 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050516 name: inositol polyphosphate multikinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [EC:2.7.1.151, MetaCyc:2.7.1.151-RXN] comment: This term was made obsolete because this activity is currently defined as catalyzing two sequential reactions based on a gene product. However, "inositol polyphosphate multikinase activity" in some organisms can catalyze additional reactions. In addition, the reactions listed in the definition can be catalyzed independently by other gene products. synonym: "ArgRIII" RELATED [EC:2.7.1.151] synonym: "AtIpk2-alpha activity" NARROW [EC:2.7.1.151] synonym: "AtIpk2-beta activity" NARROW [EC:2.7.1.151] synonym: "AtIpk2alpha" RELATED [EC:2.7.1.151] synonym: "AtIpk2beta" RELATED [EC:2.7.1.151] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.151] synonym: "inositol polyphosphate 6-/3-/5-kinase activity" EXACT [EC:2.7.1.151] synonym: "inositol-polyphosphate multikinase activity" EXACT [] synonym: "IP3/IP4 6-/3-kinase activity" EXACT [EC:2.7.1.151] synonym: "IP3/IP4 dual-specificity 6-/3-kinase activity" EXACT [EC:2.7.1.151] synonym: "IpK2 activity" RELATED [EC:2.7.1.151] synonym: "IpmK" RELATED [EC:2.7.1.151] xref: EC:2.7.1.151 xref: MetaCyc:2.7.1.151-RXN is_obsolete: true [Term] id: GO:0050517 name: inositol hexakisphosphate kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.21, MetaCyc:2.7.4.21-RXN] comment: Note that this was EC:2.7.1.152. This term was made obsolete because this activity is currently defined as catalyzing two reactions based on a gene product. The reactions listed in the definition can be catalyzed independently by other gene products. synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.4.21] synonym: "ATP:1D-myo-inositol-hexakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.21] synonym: "inositol-hexakisphosphate kinase activity" EXACT [] xref: EC:2.7.4.21 xref: MetaCyc:2.7.1.152-RXN is_obsolete: true [Term] id: GO:0050518 name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity namespace: molecular_function alt_id: GO:0008699 def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate." [EC:2.7.7.60, RHEA:13432] subset: gosubset_prok synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity" EXACT [EC:2.7.7.60] synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity" EXACT [] synonym: "CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" EXACT [] synonym: "MCT activity" RELATED [EC:2.7.7.60] synonym: "MEP cytidylyltransferase activity" EXACT [] xref: EC:2.7.7.60 xref: KEGG:R05633 xref: MetaCyc:2.7.7.60-RXN xref: RHEA:13432 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0050519 name: holo-citrate lyase synthase activity namespace: molecular_function def: "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase." [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN] subset: gosubset_prok synonym: "2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity" EXACT [EC:2.7.7.61] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity" EXACT [EC:2.7.7.61] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity" EXACT [EC:2.7.7.61] synonym: "CitX" RELATED [EC:2.7.7.61] synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61] xref: EC:2.7.7.61 xref: MetaCyc:2.7.7.61-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0050520 name: phosphatidylcholine synthase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)." [EC:2.7.8.24, RHEA:14600] subset: gosubset_prok synonym: "CDP-diacylglycerol:choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] synonym: "CDP-diglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] synonym: "CDPdiglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] synonym: "PC synthase activity" EXACT [EC:2.7.8.24] xref: EC:2.7.8.24 xref: KEGG:R05794 xref: MetaCyc:2.7.8.24-RXN xref: RHEA:14600 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0050521 name: alpha-glucan, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate." [EC:2.7.9.4, MetaCyc:2.7.9.4-RXN] synonym: "a-glucan, water dikinase activity" EXACT [] synonym: "alpha-glucan,water dikinase activity" EXACT [EC:2.7.9.4] synonym: "ATP:alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.4] synonym: "GWD" RELATED [EC:2.7.9.4] synonym: "starch-related R1 protein activity" EXACT [EC:2.7.9.4] xref: EC:2.7.9.4 xref: MetaCyc:2.7.9.4-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0050522 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.20.98 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0050523 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0030613 [Term] id: GO:0050524 name: coenzyme-B sulfoethylthiotransferase activity namespace: molecular_function alt_id: GO:0018552 def: "Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB." [EC:2.8.4.1, RHEA:12535] subset: gosubset_prok synonym: "2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity" EXACT [EC:2.8.4.1] synonym: "coenzyme-B sulphoethylthiotransferase activity" EXACT [] synonym: "methyl coenzyme M reductase activity" EXACT [EC:2.8.4.1] synonym: "methyl-coenzyme-M reductase activity" EXACT [] synonym: "methyl-CoM reductase activity" EXACT [EC:2.8.4.1] xref: EC:2.8.4.1 xref: KEGG:R04541 xref: MetaCyc:METHYL-COM-HTP-RXN xref: RHEA:12535 xref: UM-BBD_reactionID:r0356 is_a: GO:0050497 ! transferase activity, transferring alkylthio groups [Term] id: GO:0050525 name: cutinase activity namespace: molecular_function def: "Catalysis of the reaction: cutin + H2O = cutin monomers." [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN] subset: gosubset_prok synonym: "cutin hydrolase activity" EXACT [EC:3.1.1.74] xref: EC:3.1.1.74 xref: MetaCyc:3.1.1.74-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050526 name: poly(3-hydroxybutyrate) depolymerase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x = 1-5." [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN] subset: gosubset_prok synonym: "PHB depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.75] synonym: "poly(3HB) depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly(HA(SCL)) depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly(HA) depolymerase activity" RELATED [EC:3.1.1.75] synonym: "poly(HASCL) depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" EXACT [EC:3.1.1.75] synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75] xref: EC:3.1.1.75 xref: MetaCyc:3.1.1.75-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050527 name: poly(3-hydroxyoctanoate) depolymerase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x = 1-5." [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN] subset: gosubset_prok synonym: "PHA depolymerase activity" BROAD [EC:3.1.1.76] synonym: "PHO depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly((R)-3-hydroxyoctanoate) hydrolase activity" EXACT [EC:3.1.1.76] synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.76] synonym: "poly(3HO) depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly(HA(MCL)) depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly(HA) depolymerase activity" BROAD [EC:3.1.1.76] synonym: "poly(HAMCL) depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly[(R)-3-hydroxyoctanoate] hydrolase activity" EXACT [EC:3.1.1.76] synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.76] synonym: "poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity" EXACT [EC:3.1.1.76] xref: EC:3.1.1.76 xref: MetaCyc:3.1.1.76-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050528 name: acyloxyacyl hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN] xref: EC:3.1.1.77 xref: MetaCyc:3.1.1.77-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050529 name: polyneuridine-aldehyde esterase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + polyneuridine aldehyde = 16-epivellosimine + CO(2) + methanol." [EC:3.1.1.78, RHEA:17504] synonym: "PNAE activity" EXACT [EC:3.1.1.78] synonym: "polyneuridine aldehyde esterase activity" EXACT [EC:3.1.1.78] synonym: "polyneuridine aldehyde hydrolase (decarboxylating)" EXACT [EC:3.1.1.78] xref: EC:3.1.1.78 xref: KEGG:R05825 xref: MetaCyc:3.1.1.78-RXN xref: RHEA:17504 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050530 name: glucosylglycerol 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H(2)O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate." [EC:3.1.3.69, RHEA:22655] subset: gosubset_prok synonym: "2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.69] synonym: "salt tolerance protein A" RELATED [EC:3.1.3.69] synonym: "StpA" RELATED [EC:3.1.3.69] xref: EC:3.1.3.69 xref: KEGG:R05791 xref: MetaCyc:3.1.3.69-RXN xref: RHEA:22655 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050531 name: mannosyl-3-phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate." [EC:3.1.3.70, RHEA:19312] subset: gosubset_prok synonym: "alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.70] xref: EC:3.1.3.70 xref: KEGG:R05790 xref: MetaCyc:3.1.3.70-RXN xref: RHEA:19312 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050532 name: 2-phosphosulfolactate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H(2)O = (R)-3-sulfolactate + phosphate." [EC:3.1.3.71, RHEA:23419] subset: gosubset_prok synonym: "(2R)-phosphosulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71] synonym: "(R)-2-phospho-3-sulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71] synonym: "2-phosphosulpholactate phosphatase activity" EXACT [] synonym: "ComB phosphatase activity" RELATED [EC:3.1.3.71] xref: EC:3.1.3.71 xref: KEGG:R05789 xref: MetaCyc:R229-RXN xref: RHEA:23419 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050533 name: 5-phytase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate." [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN] synonym: "myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.72] xref: EC:3.1.3.72 xref: MetaCyc:3.1.3.72-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050534 name: 3-deoxyoctulosonase activity namespace: molecular_function def: "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide." [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN] synonym: "3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity" EXACT [EC:3.2.1.144] synonym: "alpha-Kdo-ase activity" EXACT [EC:3.2.1.144] xref: EC:3.2.1.144 xref: MetaCyc:3.2.1.144-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0050535 name: beta-primeverosidase activity namespace: molecular_function def: "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol." [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN] synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity" EXACT [EC:3.2.1.149] synonym: "b-primeverosidase activity" EXACT [] xref: EC:3.2.1.149 xref: MetaCyc:3.2.1.149-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0050536 name: (S)-N-acetyl-1-phenylethylamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylphenylethylamine + H(2)O = acetate + phenylethylamine." [EC:3.5.1.85, RHEA:23955] synonym: "(S)-N-acetyl-1-phenylethylamine amidohydrolase activity" EXACT [EC:3.5.1.85] synonym: "(S)-N-acetylphenylethylamine:H2O hydrolase activity" EXACT [EC:3.5.1.85] xref: EC:3.5.1.85 xref: KEGG:R07301 xref: MetaCyc:3.5.1.85-RXN xref: RHEA:23955 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050537 name: mandelamide amidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mandelamide + H(2)O = (R)-mandelate + NH(4)(+)." [EC:3.5.1.86, RHEA:22879] synonym: "mandelamide hydrolase activity" EXACT [EC:3.5.1.86] synonym: "Pseudomonas mandelamide hydrolase activity" EXACT [EC:3.5.1.86] xref: EC:3.5.1.86 xref: KEGG:R05783 xref: MetaCyc:3.5.1.86-RXN xref: RHEA:22879 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050538 name: N-carbamoyl-L-amino-acid hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate." [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN] subset: gosubset_prok synonym: "L-carbamoylase activity" EXACT [EC:3.5.1.87] synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" EXACT [EC:3.5.1.87] xref: EC:3.5.1.87 xref: MetaCyc:3.5.1.87-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050539 name: maleimide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + maleimide = H(+) + maleamate." [EC:3.5.2.16, RHEA:24479] synonym: "cyclic imide hydrolase activity" EXACT [EC:3.5.2.16] synonym: "cyclic-imide amidohydrolase (decyclicizing)" EXACT [EC:3.5.2.16] synonym: "cyclic-imide amidohydrolase (decyclizing)" EXACT [EC:3.5.2.16] synonym: "imidase activity" BROAD [EC:3.5.2.16] xref: EC:3.5.2.16 xref: KEGG:R05781 xref: MetaCyc:3.5.2.16-RXN xref: RHEA:24479 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0050540 name: 2-aminomuconate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminomuconate + H(2)O + H(+) = (Z)-5-oxohex-2-enedioate + NH(4)(+)." [EC:3.5.99.5, RHEA:20999] subset: gosubset_prok synonym: "2-aminomuconate aminohydrolase activity" EXACT [EC:3.5.99.5] xref: EC:3.5.99.5 xref: KEGG:R03887 xref: MetaCyc:3.5.99.5-RXN xref: RHEA:20999 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050541 name: beta,beta-carotene-9',10'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone." [PMID:11278918] synonym: "b,b-carotene-9',10'-dioxygenase activity" EXACT [] is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0050542 name: icosanoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "eicosanoid binding" EXACT [] is_a: GO:0005504 ! fatty acid binding [Term] id: GO:0050543 name: icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "eicosatetraenoic acid binding" EXACT [] is_a: GO:0050542 ! icosanoid binding [Term] id: GO:0050544 name: arachidonic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GOC:ai] synonym: "arachidonate binding" EXACT [] is_a: GO:0050543 ! icosatetraenoic acid binding [Term] id: GO:0050545 name: sulfopyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfopyruvate + H(+) = CO(2) + sulfoacetaldehyde." [EC:4.1.1.79, RHEA:20951] subset: gosubset_prok synonym: "sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)" EXACT [EC:4.1.1.79] synonym: "sulfopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.79] synonym: "sulphopyruvate decarboxylase activity" EXACT [] xref: EC:4.1.1.79 xref: KEGG:R05774 xref: MetaCyc:R231-RXN xref: RHEA:20951 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050546 name: 4-hydroxyphenylpyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO(2)." [EC:4.1.1.80, RHEA:18700] synonym: "4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)" EXACT [EC:4.1.1.80] synonym: "4-hydroxyphenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.80] xref: EC:4.1.1.80 xref: KEGG:R03341 xref: MetaCyc:4.1.1.80-RXN xref: RHEA:18700 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050547 name: vanillin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin." [EC:4.1.2.41, RHEA:18728] synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41] synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41] xref: EC:4.1.2.41 xref: KEGG:R05773 xref: MetaCyc:4.1.2.41-RXN xref: RHEA:18728 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050548 name: trans-feruloyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA." [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN] synonym: "4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)" EXACT [EC:4.2.1.101] synonym: "trans-feruloyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.101] xref: EC:4.2.1.101 xref: MetaCyc:4.2.1.101-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050549 name: cyclohexyl-isocyanide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: N-cyclohexylformamide + H(+) = cyclohexyl isocyanide + H(2)O." [EC:4.2.1.103, RHEA:18200] subset: gosubset_prok synonym: "isonitrile hydratase activity" EXACT [EC:4.2.1.103] synonym: "N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)" EXACT [EC:4.2.1.103] synonym: "N-cyclohexylformamide hydro-lyase activity" EXACT [EC:4.2.1.103] xref: EC:4.2.1.103 xref: KEGG:R05771 xref: MetaCyc:4.2.1.103-RXN xref: RHEA:18200 xref: UM-BBD_reactionID:r1029 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050550 name: pinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate." [EC:4.2.3.14, MetaCyc:4.2.3.14-RXN] synonym: "(-)-(1S,5S)-pinene synthase activity" EXACT [EC:4.2.3.14] synonym: "beta-geraniolene synthase activity" EXACT [EC:4.2.3.14] synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)" EXACT [EC:4.2.3.14] synonym: "geranyldiphosphate diphosphate lyase (pinene forming)" EXACT [EC:4.2.3.14] xref: EC:4.2.3.14 xref: MetaCyc:4.2.3.14-RXN is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0050551 name: myrcene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene." [EC:4.2.3.15, RHEA:16968] synonym: "geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity" EXACT [] xref: EC:4.2.3.15 xref: KEGG:R02009 xref: MetaCyc:RXN-5110 xref: RHEA:16968 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0050552 name: (4S)-limonene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = limonene + diphosphate." [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN] synonym: "(-)-(4S)-limonene synthase activity" EXACT [] synonym: "4S-(-)-limonene synthase activity" EXACT [EC:4.2.3.16] synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]" RELATED [EC:4.2.3.16] synonym: "geranyldiphosphate diphosphate lyase (limonene forming)" EXACT [EC:4.2.3.16] synonym: "geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]" RELATED [EC:4.2.3.16] xref: EC:4.2.3.16 xref: MetaCyc:4.2.3.16-RXN is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0050553 name: taxadiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene." [EC:4.2.3.17, RHEA:20915] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)" EXACT [EC:4.2.3.17] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)" EXACT [EC:4.2.3.17] synonym: "taxa-4(5),11(12)-diene synthase activity" EXACT [EC:4.2.3.17] xref: EC:4.2.3.17 xref: KEGG:R06305 xref: MetaCyc:4.2.3.17-RXN xref: RHEA:20915 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050554 name: abietadiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate." [EC:4.2.3.18, RHEA:13876] synonym: "(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)" EXACT [EC:4.2.3.18] synonym: "abietadiene cyclase activity" EXACT [EC:4.2.3.18] synonym: "copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.18] xref: EC:4.2.3.18 xref: KEGG:R06301 xref: MetaCyc:4.2.3.18-RXN xref: RHEA:13876 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050555 name: 2-hydroxypropyl-CoM lyase activity namespace: molecular_function def: "Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane." [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN] subset: gosubset_prok synonym: "(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] synonym: "(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] synonym: "2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] synonym: "coenzyme M-epoxyalkane ligase activity" EXACT [EC:4.4.1.23] synonym: "EaCoMT activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkane:2-mercaptoethanesulfonate transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkane:coenzyme M transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkane:CoM transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkyl:CoM transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxypropane:coenzyme M transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxypropyl:CoM transferase activity" EXACT [EC:4.4.1.23] xref: EC:4.4.1.23 xref: MetaCyc:4.2.99.19-RXN xref: UM-BBD_enzymeID:e0538 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0050556 name: deacetylisoipecoside synthase activity namespace: molecular_function def: "Catalysis of the reaction: deacetylisoipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.3, RHEA:21759] synonym: "deacetylisoipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.3] synonym: "deacetylisoipecoside dopamine-lyase activity" EXACT [EC:4.3.3.3] xref: EC:4.3.3.3 xref: KEGG:R05750 xref: MetaCyc:4.3.3.3-RXN xref: RHEA:21759 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0050557 name: deacetylipecoside synthase activity namespace: molecular_function def: "Catalysis of the reaction: deacetylipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.4, RHEA:12299] synonym: "deacetylipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.4] synonym: "deacetylipecoside dopamine-lyase activity" EXACT [EC:4.3.3.4] xref: EC:4.3.3.4 xref: KEGG:R05749 xref: MetaCyc:4.3.3.4-RXN xref: RHEA:12299 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0050558 name: maltose epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-maltose = beta-maltose." [EC:5.1.3.21, RHEA:21231] synonym: "maltose 1-epimerase activity" EXACT [EC:5.1.3.21] xref: EC:5.1.3.21 xref: KEGG:R07319 xref: MetaCyc:5.1.3.21-RXN xref: RHEA:21231 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050559 name: copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate." [EC:5.5.1.12, RHEA:24319] synonym: "(+)-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.12] synonym: "diterpene cyclase activity" BROAD [] xref: EC:5.5.1.12 xref: KEGG:R06298 xref: MetaCyc:RXN-4861 xref: RHEA:24319 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0050560 name: aspartate-tRNA(Asn) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP." [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN] synonym: "aspartate-tRNAAsn ligase activity" EXACT [] synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" EXACT [EC:6.1.1.23] synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23] xref: EC:6.1.1.23 xref: MetaCyc:6.1.1.23-RXN is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0050561 name: glutamate-tRNA(Gln) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP." [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN] synonym: "glutamate-tRNAGln ligase activity" EXACT [] synonym: "L-glutamate:tRNAGlx ligase (AMP-forming)" EXACT [EC:6.1.1.24] synonym: "nondiscriminating glutamyl-tRNA synthetase activity" RELATED [EC:6.1.1.24] xref: EC:6.1.1.24 xref: MetaCyc:6.1.1.24-RXN is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0050562 name: lysine-tRNA(Pyl) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP." [EC:6.1.1.25, MetaCyc:6.1.1.25-RXN] synonym: "L-lysine:tRNAPyl ligase (AMP-forming)" EXACT [EC:6.1.1.25] synonym: "lysine-tRNAPyl ligase activity" EXACT [] xref: EC:6.1.1.25 xref: MetaCyc:6.1.1.25-RXN is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0050563 name: trans-feruloyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown." [EC:6.2.1.34, MetaCyc:6.2.1.34-RXN] synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" EXACT [EC:6.2.1.34] synonym: "trans-feruloyl-CoA synthetase activity" EXACT [EC:6.2.1.34] xref: EC:6.2.1.34 xref: MetaCyc:6.2.1.34-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050564 name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H(2)O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H(+)." [EC:6.3.2.26, RHEA:23199] subset: gosubset_prok synonym: "ACV synthetase activity" BROAD [EC:6.3.2.26] synonym: "L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)" EXACT [EC:6.3.2.26] synonym: "L-alpha-aminoadipyl-cysteinyl-valine synthetase activity" EXACT [EC:6.3.2.26] synonym: "L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity" EXACT [EC:6.3.2.26] xref: EC:6.3.2.26 xref: KEGG:R04870 xref: MetaCyc:6.3.2.26-RXN xref: RHEA:23199 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0050565 name: aerobactin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 N(6)-acetyl-N(6)-hydroxy-L-lysine + 4 ATP + citrate + 2 H(2)O = 4 ADP + aerobactin + 8 H(+) + 4 phosphate." [EC:6.3.2.27, RHEA:11763] synonym: "citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27] synonym: "citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27] xref: EC:6.3.2.27 xref: KEGG:R04357 xref: MetaCyc:6.3.2.27-RXN xref: RHEA:11763 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0050566 name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP." [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN] synonym: "Asp-AdT activity" EXACT [EC:6.3.5.6] synonym: "Asp-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "Asp-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6] synonym: "asparaginyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.6] synonym: "aspartyl-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "aspartyl-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6] xref: EC:6.3.5.6 xref: MetaCyc:6.3.5.6-RXN xref: Wikipedia:Asparaginyl-tRNA_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0050567 name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity namespace: molecular_function alt_id: GO:0008264 alt_id: GO:0017068 def: "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] subset: gosubset_prok synonym: "Glu-AdT activity" EXACT [EC:6.3.5.-] synonym: "glu-tRNA(gln) amidotransferase activity" EXACT [EC:6.3.5.-] synonym: "Glu-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-] synonym: "Glu-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7] synonym: "Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7] synonym: "glutaminyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.7] synonym: "glutamyl-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-] synonym: "glutamyl-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7] synonym: "glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7] xref: EC:6.3.5.7 xref: MetaCyc:6.3.5.7-RXN xref: Wikipedia:Glutaminyl-tRNA_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0050568 name: protein-glutamine glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3." [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN] synonym: "destabilase activity" EXACT [EC:3.5.1.44] synonym: "glutaminyl-peptide glutaminase activity" EXACT [EC:3.5.1.44] synonym: "glutaminylpeptide glutaminase activity" EXACT [EC:3.5.1.44] synonym: "peptidoglutaminase II activity" RELATED [EC:3.5.1.44] synonym: "peptidylglutaminase II" RELATED [EC:3.5.1.44] synonym: "protein-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.44] xref: EC:3.5.1.44 xref: MetaCyc:CHEBDEAMID-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050569 name: glycolaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycolaldehyde + H(2)O + NAD(+) = glycolate + 2 H(+) + NADH." [EC:1.2.1.21, RHEA:20004] subset: gosubset_prok synonym: "glycol aldehyde dehydrogenase activity" EXACT [EC:1.2.1.21] synonym: "glycolaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.21] xref: EC:1.2.1.21 xref: KEGG:R01333 xref: MetaCyc:GLYCOLALD-DEHYDROG-RXN xref: RHEA:20004 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050570 name: 4-hydroxythreonine-4-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+." [EC:1.1.1.262, MetaCyc:1.1.1.262-RXN] subset: gosubset_prok synonym: "4-(phosphohydroxy)-L-threonine dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.262] synonym: "L-threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "NAD(+)-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "NAD+-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "PdxA" RELATED [EC:1.1.1.262] xref: EC:1.1.1.262 xref: MetaCyc:1.1.1.262-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050571 name: 1,5-anhydro-D-fructose reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH." [EC:1.1.1.263, RHEA:20668] synonym: "1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.263] synonym: "AF reductase activity" EXACT [EC:1.1.1.263] xref: EC:1.1.1.263 xref: KEGG:R05682 xref: MetaCyc:1.1.1.263-RXN xref: RHEA:20668 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050572 name: L-idonate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+." [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN] subset: gosubset_prok synonym: "L-idonate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.264] xref: EC:1.1.1.264 xref: MetaCyc:1.1.1.264-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050573 name: dTDP-4-dehydro-6-deoxyglucose reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH." [EC:1.1.1.266, RHEA:21903] synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.1.1.266] synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.266] xref: EC:1.1.1.266 xref: KEGG:R05687 xref: MetaCyc:1.1.1.266-RXN xref: RHEA:21903 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050574 name: 2-(R)-hydroxypropyl-CoM dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.268, RHEA:13252] subset: gosubset_prok synonym: "2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.268] synonym: "2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.268] xref: EC:1.1.1.268 xref: KEGG:R05689 xref: MetaCyc:1.1.1.268-RXN xref: RHEA:13252 xref: UM-BBD_reactionID:r0852 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050575 name: 2-(S)-hydroxypropyl-CoM dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.269, RHEA:21055] subset: gosubset_prok synonym: "2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.269] synonym: "2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.269] xref: EC:1.1.1.269 xref: KEGG:R05690 xref: MetaCyc:1.1.1.269-RXN xref: RHEA:21055 xref: UM-BBD_reactionID:r0853 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050577 name: GDP-L-fucose synthase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN] subset: gosubset_prok synonym: "GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity" EXACT [EC:1.1.1.271] synonym: "GDP-fucose synthetase activity" EXACT [EC:1.1.1.271] synonym: "GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)" EXACT [EC:1.1.1.271] xref: EC:1.1.1.271 xref: MetaCyc:1.1.1.271-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050578 name: (R)-2-hydroxyacid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+." [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN] subset: gosubset_prok synonym: "(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "(R)-sulfolactate:NAD(P)(+) oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "L-sulfolactate dehydrogenase activity" EXACT [EC:1.1.1.272] xref: EC:1.1.1.272 xref: MetaCyc:1.1.1.272-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050579 name: vellosimine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine." [EC:1.1.1.273, RHEA:20032] synonym: "10-deoxysarpagine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.273] xref: EC:1.1.1.273 xref: KEGG:R05827 xref: MetaCyc:1.1.1.273-RXN xref: RHEA:20032 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050580 name: 2,5-didehydrogluconate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+." [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN] subset: gosubset_prok synonym: "2,5-diketo-D-gluconate reductase activity" EXACT [EC:1.1.1.274] synonym: "2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.274] synonym: "YqhE reductase" RELATED [EC:1.1.1.274] xref: EC:1.1.1.274 xref: MetaCyc:1.1.1.274-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050581 name: D-mannitol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: mannitol + O2 = mannose + H2O2." [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN] synonym: "D-arabinitol oxidase activity" RELATED [EC:1.1.3.40] synonym: "D-arabitol oxidase activity" EXACT [EC:1.1.3.40] synonym: "mannitol oxidase activity" EXACT [EC:1.1.3.40] synonym: "mannitol:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.1.3.40] xref: EC:1.1.3.40 xref: MetaCyc:1.1.3.40-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050582 name: xylitol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: xylitol + O2 = xylose + H2O2." [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN] subset: gosubset_prok synonym: "xylitol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.41] xref: EC:1.1.3.41 xref: MetaCyc:1.1.3.41-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050583 name: hydrogen dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + H2 = NADPH + H+." [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN] synonym: "hydrogen:NADP+ oxidoreductase activity" EXACT [EC:1.12.1.3] synonym: "NADP-linked hydrogenase activity" RELATED [EC:1.12.1.3] synonym: "NADP-reducing hydrogenase activity" RELATED [EC:1.12.1.3] xref: EC:1.12.1.3 xref: MetaCyc:1.12.1.3-RXN is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor [Term] id: GO:0050584 name: linoleate 11-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O(2) = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate." [EC:1.13.11.45, RHEA:18996] synonym: "linoleate dioxygenase activity" EXACT [EC:1.13.11.45] synonym: "linoleate:oxygen 11S-oxidoreductase activity" EXACT [EC:1.13.11.45] synonym: "manganese lipoxygenase activity" EXACT [EC:1.13.11.45] xref: EC:1.13.11.45 xref: KEGG:R05718 xref: MetaCyc:1.13.11.45-RXN xref: RHEA:18996 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050585 name: 4-hydroxymandelate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2." [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN] synonym: "4-hydroxyphenylpyruvate dioxygenase II activity" NARROW [EC:1.13.11.46] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.13.11.46] xref: EC:1.13.11.46 xref: MetaCyc:1.13.11.46-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050586 name: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H(+) + O(2) = N-acetylanthranilate + CO." [EC:1.13.11.48, RHEA:21575] subset: gosubset_prok synonym: "(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [EC:1.13.11.48] synonym: "1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity" EXACT [] synonym: "1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [] synonym: "3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.48] synonym: "3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity" EXACT [] xref: EC:1.13.11.48 xref: KEGG:R05720 xref: MetaCyc:1.13.11.48-RXN xref: RHEA:21575 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050587 name: chlorite O2-lyase activity namespace: molecular_function alt_id: GO:0030065 def: "Catalysis of the reaction: chloride + O(2) = chlorite." [EC:1.13.11.49, RHEA:21407] synonym: "chloride:oxygen oxidoreductase activity" EXACT [EC:1.13.11.49] synonym: "chlorite dismutase activity" EXACT [EC:1.13.11.49] xref: EC:1.13.11.49 xref: KEGG:R05721 xref: MetaCyc:1.13.11.49-RXN xref: RHEA:21407 xref: UM-BBD_reactionID:r0982 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050588 name: apo-beta-carotenoid-14',13'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 8'-apo-beta-carotenol + O(2) = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal." [EC:1.13.12.12, RHEA:26026] synonym: "8'-apo-beta-carotenol:O2 oxidoreductase activity" EXACT [EC:1.13.12.12] synonym: "apo-b-carotenoid-14',13'-dioxygenase activity" EXACT [] xref: EC:1.13.12.12 xref: KEGG:R08889 xref: MetaCyc:1.13.12.12-RXN xref: RHEA:26026 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050589 name: leucocyanidin oxygenase activity namespace: molecular_function alt_id: GO:0045432 def: "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O." [EC:1.14.11.19, MetaCyc:1.14.11.19-RXN] synonym: "anthocyanidin synthase activity" RELATED [EC:1.14.11.19] synonym: "leucoanthocyanidin dioxygenase activity" EXACT [EC:1.14.11.19] synonym: "leucoanthocyanidin hydroxylase" RELATED [EC:1.14.11.19] synonym: "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.19] xref: EC:1.14.11.19 xref: MetaCyc:RXN-602 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0050590 name: desacetoxyvindoline 4-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2." [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN] synonym: "D17H activity" RELATED [EC:1.14.11.20] synonym: "deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20] synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity" EXACT [EC:1.14.11.20] synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20] synonym: "desacetoxyvindoline-4-hydroxylase activity" EXACT [EC:1.14.11.20] synonym: "desacetyoxyvindoline-17-hydroxylase activity" EXACT [EC:1.14.11.20] xref: EC:1.14.11.20 xref: MetaCyc:1.14.11.20-RXN is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0050591 name: quinine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152] synonym: "nifedipine oxidase activity" EXACT [EC:1.14.13.67] synonym: "quinine 3-hydroxylase activity" EXACT [] synonym: "quinine,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.67] xref: EC:1.14.13.67 xref: KEGG:R05727 xref: MetaCyc:1.14.13.67-RXN xref: RHEA:20152 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050592 name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+)." [EC:1.14.13.68, RHEA:18404] synonym: "(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68] synonym: "4-hydroxybenzeneacetaldehyde oxime monooxygenase activity" EXACT [EC:1.14.13.68] synonym: "4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68] synonym: "CYP71E1 activity" NARROW [EC:1.14.13.68] synonym: "cytochrome P450-II-dependent monooxygenase activity" NARROW [EC:1.14.13.68] synonym: "cytochrome P450II-dependent monooxygenase activity" EXACT [EC:1.14.13.68] synonym: "NADPH-cytochrome P450 reductase (CYP71E1)" EXACT [EC:1.14.13.68] xref: EC:1.14.13.68 xref: KEGG:R05728 xref: MetaCyc:1.14.13.68-RXN xref: RHEA:18404 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050593 name: N-methylcoclaurine 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+)." [EC:1.14.13.71, RHEA:16652] synonym: "(S)-N-methylcoclaurine 3'-hydroxylase activity" EXACT [EC:1.14.13.71] synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.71] synonym: "cytochrome P450 80B1 activity" EXACT [EC:1.14.13.71] synonym: "N-methylcoclaurine 3'-hydroxylase activity" EXACT [] xref: EC:1.14.13.71 xref: KEGG:R05732 xref: MetaCyc:1.14.13.71-RXN xref: RHEA:16652 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050594 name: tabersonine 16-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+)." [EC:1.14.13.73, RHEA:14136] synonym: "tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)" EXACT [EC:1.14.13.73] xref: EC:1.14.13.73 xref: KEGG:R05855 xref: MetaCyc:1.14.13.73-RXN xref: RHEA:14136 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050595 name: 7-deoxyloganin 7-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O." [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN] synonym: "7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.74] xref: EC:1.14.13.74 xref: MetaCyc:1.14.13.74-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050596 name: vinorine hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + vinorine = H(2)O + NADP(+) + vomilenine." [EC:1.14.13.75, RHEA:17260] synonym: "vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)" EXACT [EC:1.14.13.75] xref: EC:1.14.13.75 xref: KEGG:R05877 xref: MetaCyc:1.14.13.75-RXN xref: RHEA:17260 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050597 name: taxane 10-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+)." [EC:1.14.13.76, RHEA:15244] synonym: "5-alpha-taxadienol-10-beta-hydroxylase activity" EXACT [EC:1.14.13.76] synonym: "taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)" EXACT [EC:1.14.13.76] synonym: "taxane 10b-hydroxylase activity" EXACT [] synonym: "taxane 10beta-hydroxylase activity" EXACT [EC:1.14.13.76] xref: EC:1.14.13.76 xref: KEGG:R06309 xref: MetaCyc:1.14.13.76-RXN xref: RHEA:15244 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050598 name: taxane 13-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol." [EC:1.14.13.77, RHEA:18952] synonym: "taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)" EXACT [EC:1.14.13.77] synonym: "taxane 13a-hydroxylase activity" EXACT [] synonym: "taxane 13alpha-hydroxylase activity" EXACT [EC:1.14.13.77] xref: EC:1.14.13.77 xref: KEGG:R06308 xref: MetaCyc:1.14.13.77-RXN xref: RHEA:18952 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050599 name: deacetoxycephalosporin-C synthase activity namespace: molecular_function alt_id: GO:0045441 def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate." [EC:1.14.20.1, RHEA:20751] subset: gosubset_prok synonym: "DAOC synthase activity" EXACT [EC:1.14.20.1] synonym: "DAOCS activity" EXACT [EC:1.14.20.1] synonym: "deacetoxycephalosporin C synthetase activity" EXACT [] synonym: "expandase activity" EXACT [] synonym: "penicillin N expandase activity" RELATED [EC:1.14.20.1] synonym: "penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)" EXACT [EC:1.14.20.1] xref: EC:1.14.20.1 xref: KEGG:R05301 xref: MetaCyc:1.14.20.1-RXN xref: RHEA:20751 is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated [Term] id: GO:0050600 name: myristoyl-CoA 11-(E) desaturase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.31, MetaCyc:1.14.99.31-RXN] synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31] synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31] xref: EC:1.14.99.31 xref: MetaCyc:1.14.99.31-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050601 name: myristoyl-CoA 11-(Z) desaturase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.32, MetaCyc:1.14.99.32-RXN] synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32] synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32] xref: EC:1.14.99.32 xref: MetaCyc:1.14.99.32-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050602 name: monoprenyl isoflavone epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives." [EC:1.14.99.34, MetaCyc:1.14.99.34-RXN] synonym: "7-O-methylluteone,NADPH:O2 oxidoreductase activity" EXACT [EC:1.14.99.34] synonym: "7-O-methylluteone:O2 oxidoreductase activity" EXACT [EC:1.14.99.34] synonym: "monoprenyl isoflavone monooxygenase activity" EXACT [EC:1.14.99.34] xref: EC:1.14.99.34 xref: MetaCyc:1.14.99.34-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050603 name: thiophene-2-carbonyl-CoA monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(2)O + H(+)." [EC:1.14.99.35, RHEA:18932] synonym: "thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.35] synonym: "thiophene-2-carboxyl-CoA dehydrogenase activity" EXACT [EC:1.14.99.35] synonym: "thiophene-2-carboxyl-CoA hydroxylase activity" EXACT [EC:1.14.99.35] synonym: "thiophene-2-carboxyl-CoA monooxygenase activity" EXACT [EC:1.14.99.35] xref: EC:1.14.99.35 xref: KEGG:R05742 xref: MetaCyc:1.14.99.35-RXN xref: RHEA:18932 xref: UM-BBD_reactionID:r1235 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050604 name: taxadiene 5-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + taxa-4,11-diene = A + H(2)O + taxa-4(20),11-dien-5alpha-ol." [EC:1.14.99.37, RHEA:14052] synonym: "taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)" EXACT [EC:1.14.99.37] synonym: "taxadiene 5a-hydroxylase activity" EXACT [] synonym: "taxadiene 5alpha-hydroxylase activity" EXACT [EC:1.14.99.37] xref: EC:1.14.99.37 xref: KEGG:R06306 xref: MetaCyc:1.14.99.37-RXN xref: RHEA:14052 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050605 name: superoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin." [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN] subset: gosubset_prok synonym: "desulfoferrodoxin activity" RELATED [EC:1.15.1.2] synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2] synonym: "rubredoxin:superoxide oxidoreductase activity" EXACT [EC:1.15.1.2] xref: EC:1.15.1.2 xref: MetaCyc:1.15.1.2-RXN is_a: GO:0016209 ! antioxidant activity is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0050606 name: 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ = 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + H+." [EC:1.2.1.45, MetaCyc:1.2.1.45-RXN] synonym: "2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.45] synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase activity" EXACT [EC:1.2.1.45] synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.45] synonym: "alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.45] xref: EC:1.2.1.45 xref: MetaCyc:1.2.1.45-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050607 name: mycothiol-dependent formaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+." [EC:1.2.1.66, MetaCyc:1.2.1.66-RXN] subset: gosubset_prok synonym: "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT [EC:1.2.1.66] synonym: "NAD/factor-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.2.1.66] xref: EC:1.2.1.66 xref: MetaCyc:1.2.1.66-RXN xref: Reactome:81505 "mycothiol-dependent formaldehyde dehydrogenase activity" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050608 name: vanillin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate." [EC:1.2.1.67, RHEA:13312] synonym: "vanillin:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.67] xref: EC:1.2.1.67 xref: KEGG:R05699 xref: MetaCyc:1.2.1.67-RXN xref: RHEA:13312 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050609 name: phosphonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NAD(+) + phosphonate = 2 H(+) + NADH + phosphate." [EC:1.20.1.1, RHEA:13176] subset: gosubset_prok synonym: "NAD-dependent phosphite dehydrogenas activity" EXACT [EC:1.20.1.1] synonym: "NAD:phosphite oxidoreductase activity" EXACT [EC:1.20.1.1] synonym: "phosphite dehydrogenase activity" EXACT [EC:1.20.1.1] synonym: "phosphonate:NAD+ oxidoreductase activity" EXACT [EC:1.20.1.1] xref: EC:1.20.1.1 xref: KEGG:R05746 xref: MetaCyc:1.20.1.1-RXN xref: RHEA:13176 xref: UM-BBD_reactionID:r1055 is_a: GO:0050499 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor [Term] id: GO:0050610 name: methylarsonate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid." [EC:1.20.4.2, RHEA:15972] synonym: "gluthathione:methylarsonate oxidoreductase activity" EXACT [EC:1.20.4.2] synonym: "MMA(V) reductase activity" EXACT [EC:1.20.4.2] xref: EC:1.20.4.2 xref: KEGG:R05748 xref: MetaCyc:1.20.4.2-RXN xref: RHEA:15972 xref: UM-BBD_reactionID:r0837 is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor [Term] id: GO:0050611 name: arsenate reductase (azurin) activity namespace: molecular_function alt_id: GO:0018691 def: "Catalysis of the reaction: 2 azurin(ox) + H2O + arsenite = 2 azurin(red) + arsenate." [EC:1.20.98.1, MetaCyc:1.20.98.1-RXN] subset: gosubset_prok synonym: "arsenite oxidase activity" EXACT [EC:1.20.98.1] synonym: "arsenite:azurin oxidoreductase activity" EXACT [EC:1.20.98.1] xref: EC:1.20.98.1 xref: MetaCyc:1.20.98.1-RXN xref: UM-BBD_reactionID:r0634 is_a: GO:0050522 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors [Term] id: GO:0050612 name: arsenate reductase (donor) activity namespace: molecular_function def: "Catalysis of the reaction: A + arsenite + H(2)O = AH(2) + arsenate + 2 H(+)." [EC:1.20.99.1, RHEA:18452] synonym: "arsenate:(acceptor) oxidoreductase activity" EXACT [EC:1.20.99.1] synonym: "arsenate:acceptor oxidoreductase activity" EXACT [EC:1.20.99.1] xref: EC:1.20.99.1 xref: KEGG:R05752 xref: MetaCyc:1.20.99.1-RXN xref: RHEA:18452 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0050613 name: delta14-sterol reductase activity namespace: molecular_function alt_id: GO:0000251 def: "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity" EXACT [EC:1.3.1.70] synonym: "C-14 sterol reductase activity" EXACT [] synonym: "D14-sterol reductase activity" EXACT [] synonym: "sterol C-14 reductase activity" EXACT [] synonym: "sterol C14-reductase activity" EXACT [EC:1.3.1.70] xref: EC:1.3.1.70 xref: MetaCyc:1.3.1.70-RXN xref: Reactome:81517 "delta14-sterol reductase activity" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050614 name: delta24-sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol." [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN] synonym: "D24-sterol reductase activity" EXACT [] synonym: "lanosterol Delta(24)-reductase activity" NARROW [EC:1.3.1.72] synonym: "lanosterol delta24-reductase activity" EXACT [EC:1.3.1.72] synonym: "sterol:NADP+ delta24-oxidoreductase activity" EXACT [EC:1.3.1.72] xref: EC:1.3.1.72 xref: MetaCyc:1.3.1.72-RXN xref: Reactome:81519 "delta24-sterol reductase activity" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050615 name: 1,2-dihydrovomilenine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + H(+) + NADPH." [EC:1.3.1.73, RHEA:12323] synonym: "17-O-acetylnorajmaline:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.73] xref: EC:1.3.1.73 xref: KEGG:R05879 xref: MetaCyc:1.3.1.73-RXN xref: RHEA:12323 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050616 name: secologanin synthase activity namespace: molecular_function def: "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O." [EC:1.3.3.9, MetaCyc:1.3.3.9-RXN] synonym: "loganin:oxygen oxidoreductase (ring-cleaving)" EXACT [EC:1.3.3.9] xref: EC:1.3.3.9 xref: MetaCyc:1.3.3.9-RXN is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0050617 name: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN] subset: gosubset_prok synonym: "PebA" RELATED [EC:1.3.7.2] xref: EC:1.3.7.2 xref: MetaCyc:1.3.7.2-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050618 name: phycoerythrobilin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin." [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN] subset: gosubset_prok synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.3] synonym: "PebB" RELATED [EC:1.3.7.3] xref: EC:1.3.7.3 xref: MetaCyc:1.3.7.3-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050619 name: phytochromobilin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN] synonym: "(3Z)-phytochromobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.4] synonym: "HY2" RELATED [EC:1.3.7.4] synonym: "P-Phi-B synthase activity" RELATED [EC:1.3.7.4] synonym: "PFB synthase activity" EXACT [EC:1.3.7.4] synonym: "phytochromobilin synthase activity" EXACT [EC:1.3.7.4] synonym: "PPhiB synthase activity" EXACT [EC:1.3.7.4] xref: EC:1.3.7.4 xref: MetaCyc:1.3.7.4-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050620 name: phycocyanobilin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN] subset: gosubset_prok synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.5] xref: EC:1.3.7.5 xref: MetaCyc:1.3.7.5-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050621 name: tryptophan alpha,beta-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O(2) = alpha,beta-didehydrotryptophan + H(2)O(2) + H(+)." [EC:1.3.3.10, RHEA:19904] comment: Note that this was EC:1.4.3.17. synonym: "L-tryptophan 2',3'-oxidase activity" EXACT [EC:1.3.3.10] synonym: "L-tryptophan alpha,beta-dehydrogenase activity" EXACT [EC:1.3.3.10] synonym: "L-tryptophan:oxygen alpha,beta-oxidoreductase activity" EXACT [EC:1.3.3.10] synonym: "tryptophan a,b-oxidase activity" EXACT [] xref: EC:1.3.3.10 xref: KEGG:R05317 xref: MetaCyc:1.4.3.17-RXN xref: RHEA:19904 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0050622 name: glycine dehydrogenase (cyanide-forming) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2." [EC:1.4.99.5, MetaCyc:1.4.99.5-RXN] synonym: "glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)" EXACT [EC:1.4.99.5] synonym: "HCN synthase activity" EXACT [EC:1.4.99.5] synonym: "hydrogen cyanide synthase activity" EXACT [EC:1.4.99.5] xref: EC:1.4.99.5 xref: MetaCyc:1.4.99.5-RXN is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0050623 name: berberine reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH." [EC:1.5.1.31, RHEA:21271] synonym: "(R)-canadine synthase activity" EXACT [EC:1.5.1.31] synonym: "(R)-tetrahydroberberine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.31] xref: EC:1.5.1.31 xref: KEGG:R07169 xref: MetaCyc:1.5.1.31-RXN xref: RHEA:21271 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050624 name: vomilenine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine." [EC:1.5.1.32, RHEA:16412] synonym: "1,2-dihydrovomilenine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.32] xref: EC:1.5.1.32 xref: KEGG:R05878 xref: MetaCyc:1.5.1.32-RXN xref: RHEA:16412 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050625 name: 2-hydroxy-1,4-benzoquinone reductase activity namespace: molecular_function alt_id: GO:0018540 def: "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)." [EC:1.6.5.7, RHEA:12431] synonym: "1,2,4-trihydroxybenzene:NAD oxidoreductase activity" EXACT [EC:1.6.5.7] synonym: "1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity" EXACT [EC:1.6.5.7] synonym: "2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity" EXACT [EC:1.6.5.7] synonym: "hydroxybenzoquinone reductase activity" EXACT [EC:1.6.5.-] synonym: "NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.7] xref: EC:1.6.5.7 xref: KEGG:R05399 xref: MetaCyc:1.6.5.7-RXN xref: RHEA:12431 xref: UM-BBD_reactionID:r0667 is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: GO:0050626 name: trimethylamine-N-oxide reductase (cytochrome c) activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+." [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN] subset: gosubset_prok synonym: "TMAO reductase activity" EXACT [EC:1.7.2.3] synonym: "TOR activity" EXACT [EC:1.7.2.3] synonym: "trimethylamine:cytochrome c oxidoreductase activity" EXACT [EC:1.7.2.3] xref: EC:1.7.2.3 xref: MetaCyc:1.7.2.3-RXN xref: Wikipedia:Trimethylamine_N-oxide_reductase is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: GO:0050627 name: mycothione reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione." [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN] synonym: "mycothiol-disulfide reductase activity" EXACT [EC:1.8.1.15] synonym: "mycothiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.15] xref: EC:1.8.1.15 xref: MetaCyc:1.8.1.15-RXN xref: Reactome:81545 "mycothione reductase activity" is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0050628 name: 2-oxopropyl-CoM reductase (carboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO(2) + NADPH." [EC:1.8.1.5, RHEA:16980] subset: gosubset_prok synonym: "2-KPCC activity" EXACT [EC:1.8.1.5] synonym: "2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.8.1.5] synonym: "NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5] synonym: "NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5] xref: EC:1.8.1.5 xref: KEGG:R05713 xref: MetaCyc:1.8.1.5-RXN xref: RHEA:16980 xref: UM-BBD_reactionID:r0854 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0050629 name: tetrachloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor." [EC:1.97.1.8, MetaCyc:1.97.1.8-RXN] subset: gosubset_prok synonym: "acceptor:trichloroethene oxidoreductase (chlorinating)" EXACT [EC:1.97.1.8] synonym: "tetrachloroethene reductase activity" EXACT [EC:1.97.1.8] xref: EC:1.97.1.8 xref: MetaCyc:1.97.1.8-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0050630 name: (iso)eugenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol." [EC:2.1.1.146, MetaCyc:2.1.1.146-RXN] synonym: "isoeugenol O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity" EXACT [EC:2.1.1.146] xref: EC:2.1.1.146 xref: MetaCyc:2.1.1.146-RXN is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0050631 name: corydaline synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP(+)." [EC:2.1.1.147, RHEA:14776] synonym: "S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity" EXACT [EC:2.1.1.147] xref: EC:2.1.1.147 xref: KEGG:R07241 xref: MetaCyc:2.1.1.147-RXN xref: RHEA:14776 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0050632 name: propionyl-CoA C2-trimethyltridecanoyltransferase activity namespace: molecular_function alt_id: GO:0004770 def: "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." [EC:2.3.1.154, RHEA:10411] synonym: "3-oxopristanoyl-CoA hydrolase activity" EXACT [EC:2.3.1.154] synonym: "3-oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154] synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154] synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154] synonym: "oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154] synonym: "peroxisomal 3-oxoacyl coenzyme A thiolase" NARROW [EC:2.3.1.154] synonym: "peroxisome sterol carrier protein thiolase" NARROW [EC:2.3.1.154] synonym: "propionyl-CoA C(2)-trimethyltridecanoyltransferase activity" EXACT [] synonym: "SCPx" RELATED [EC:2.3.1.154] synonym: "sterol carrier protein" RELATED [EC:2.3.1.154] synonym: "sterol carrier protein X-related thiolase activity" RELATED [] xref: EC:2.3.1.154 xref: KEGG:R05330 xref: MetaCyc:2.3.1.154-RXN xref: Reactome:81555 "propionyl-CoA C2-trimethyltridecanoyltransferase activity" xref: RHEA:10411 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050633 name: acetyl-CoA C-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA." [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN] synonym: "3-oxopalmitoyl-CoA hydrolase activity" EXACT [EC:2.3.1.155] synonym: "3-oxopalmitoyl-CoA-CoA acetyltransferase activity" EXACT [EC:2.3.1.155] synonym: "myristoyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.155] synonym: "myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity" EXACT [EC:2.3.1.155] xref: EC:2.3.1.155 xref: MetaCyc:2.3.1.155-RXN xref: Reactome:81557 "acetyl-CoA C-myristoyltransferase activity" is_a: GO:0016408 ! C-acyltransferase activity is_a: GO:0019107 ! myristoyltransferase activity [Term] id: GO:0050634 name: phloroisovalerophenone synthase activity namespace: molecular_function def: "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one." [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN] synonym: "3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity" EXACT [EC:2.3.1.156] synonym: "isovaleryl-CoA:malonyl-CoA acyltransferase activity" EXACT [EC:2.3.1.156] synonym: "valerophenone synthase activity" EXACT [EC:2.3.1.156] xref: EC:2.3.1.156 xref: MetaCyc:2.3.1.156-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050635 name: acridone synthase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H(+) + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO(2) + 4 CoA + H(2)O." [EC:2.3.1.159, RHEA:22227] synonym: "malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.159] xref: EC:2.3.1.159 xref: KEGG:R07250 xref: MetaCyc:2.3.1.159-RXN xref: RHEA:22227 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050636 name: vinorine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine." [EC:2.3.1.160, RHEA:24019] synonym: "acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)" EXACT [EC:2.3.1.160] xref: EC:2.3.1.160 xref: KEGG:R05876 xref: MetaCyc:2.3.1.160-RXN xref: RHEA:24019 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050637 name: lovastatin nonaketide synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+)." [EC:2.3.1.161, RHEA:18568] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)" EXACT [EC:2.3.1.161] xref: EC:2.3.1.161 xref: KEGG:R07251 xref: MetaCyc:2.3.1.161-RXN xref: RHEA:18568 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050638 name: taxadien-5-alpha-ol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate." [EC:2.3.1.162, RHEA:22031] synonym: "acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162] synonym: "acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162] synonym: "acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162] synonym: "taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity" EXACT [EC:2.3.1.162] synonym: "taxadien-5a-ol O-acetyltransferase activity" EXACT [] synonym: "taxadien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162] synonym: "taxadienol acetyltransferase activity" EXACT [EC:2.3.1.162] xref: EC:2.3.1.162 xref: KEGG:R06307 xref: MetaCyc:2.3.1.162-RXN xref: RHEA:22031 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050639 name: 10-hydroxytaxane O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C." [EC:2.3.1.163, RHEA:18840] synonym: "acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163] synonym: "acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163] synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.163] xref: EC:2.3.1.163 xref: KEGG:R07252 xref: MetaCyc:2.3.1.163-RXN xref: RHEA:18840 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050640 name: isopenicillin-N N-acyltransferase activity namespace: molecular_function alt_id: GO:0042319 alt_id: GO:0045440 def: "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate." [EC:2.3.1.164, MetaCyc:2.3.1.164-RXN] synonym: "acyl-CoA:isopenicillin N N-acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "acyl-coenzyme A:isopenicillin N acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "isopenicillin N:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "isopenicillin-N acyltransferase activity" EXACT [] xref: EC:2.3.1.164 xref: MetaCyc:2.3.1.164-RXN is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0050641 name: 6-methylsalicylic acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO(2) + 4 CoA + H(2)O + NADP(+)." [EC:2.3.1.165, RHEA:12243] synonym: "6-MSAS activity" EXACT [EC:2.3.1.165] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)" EXACT [EC:2.3.1.165] synonym: "MSAS activity" EXACT [EC:2.3.1.165] xref: EC:2.3.1.165 xref: KEGG:R07253 xref: MetaCyc:2.3.1.165-RXN xref: RHEA:12243 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050642 name: 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA." [EC:2.3.1.166, RHEA:18744] synonym: "2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity" EXACT [EC:2.3.1.166] synonym: "2a-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [] synonym: "2alpha-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] synonym: "benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity" EXACT [EC:2.3.1.166] synonym: "benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] synonym: "benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] xref: EC:2.3.1.166 xref: KEGG:R06310 xref: MetaCyc:2.3.1.166-RXN xref: RHEA:18744 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050643 name: 10-deacetylbaccatin III 10-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA." [EC:2.3.1.167, RHEA:20140] synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.167] xref: EC:2.3.1.167 xref: KEGG:R06311 xref: MetaCyc:2.3.1.167-RXN xref: RHEA:20140 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050644 name: cis-p-coumarate glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP." [EC:2.4.1.209, RHEA:13132] synonym: "UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.209] xref: EC:2.4.1.209 xref: KEGG:R05324 xref: MetaCyc:2.4.1.209-RXN xref: RHEA:13132 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050645 name: limonoid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP." [EC:2.4.1.210] synonym: "LGTase activity" EXACT [EC:2.4.1.210] synonym: "limonoid UDP-glucosyltransferase activity" EXACT [EC:2.4.1.210] synonym: "uridine diphosphoglucose-limonoid glucosyltransferase activity" EXACT [EC:2.4.1.210] xref: EC:2.4.1.210 xref: MetaCyc:2.4.1.210-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050646 name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] is_a: GO:0050543 ! icosatetraenoic acid binding [Term] id: GO:0050647 name: 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] is_a: GO:0050543 ! icosatetraenoic acid binding [Term] id: GO:0050648 name: 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] is_a: GO:0050543 ! icosatetraenoic acid binding [Term] id: GO:0050649 name: testosterone 6-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O." [GOC:ai, PMID:11726664] synonym: "testosterone 6b-hydroxylase activity" EXACT [] is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0050650 name: chondroitin sulfate proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] subset: gosubset_prok synonym: "chondroitin sulfate proteoglycan anabolism" EXACT [] synonym: "chondroitin sulfate proteoglycan biosynthesis" EXACT [] synonym: "chondroitin sulfate proteoglycan formation" EXACT [] synonym: "chondroitin sulfate proteoglycan synthesis" EXACT [] synonym: "chondroitin sulphate proteoglycan biosynthesis" EXACT [] synonym: "chondroitin sulphate proteoglycan biosynthetic process" EXACT [] is_a: GO:0030166 ! proteoglycan biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process [Term] id: GO:0050651 name: dermatan sulfate proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai] subset: gosubset_prok synonym: "chondroitin sulfate B proteoglycan biosynthesis" EXACT [] synonym: "chondroitin sulfate B proteoglycan biosynthetic process" EXACT [] synonym: "dermatan sulfate proteoglycan anabolism" EXACT [] synonym: "dermatan sulfate proteoglycan biosynthesis" EXACT [] synonym: "dermatan sulfate proteoglycan formation" EXACT [] synonym: "dermatan sulfate proteoglycan synthesis" EXACT [] synonym: "dermatan sulphate proteoglycan biosynthesis" EXACT [] synonym: "dermatan sulphate proteoglycan biosynthetic process" EXACT [] is_a: GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process is_a: GO:0050655 ! dermatan sulfate proteoglycan metabolic process [Term] id: GO:0050652 name: dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process namespace: biological_process def: "The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate." [GOC:ai, PMID:11788602] subset: gosubset_prok synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] synonym: "chondroitin sulfate B proteoglycan chain elongation" EXACT [] synonym: "dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] synonym: "dermatan sulfate proteoglycan chain elongation" EXACT [] synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] synonym: "dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process [Term] id: GO:0050653 name: chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process namespace: biological_process def: "The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate." [GOC:ai, PMID:11788602] subset: gosubset_prok synonym: "chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] synonym: "chondroitin sulfate proteoglycan chain elongation" EXACT [] synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] synonym: "chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process [Term] id: GO:0050654 name: chondroitin sulfate proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] subset: gosubset_prok synonym: "chondroitin sulfate proteoglycan metabolism" EXACT [] synonym: "chondroitin sulphate proteoglycan metabolic process" EXACT [] synonym: "chondroitin sulphate proteoglycan metabolism" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0050655 name: dermatan sulfate proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai] subset: gosubset_prok synonym: "chondroitin sulfate B proteoglycan metabolic process" EXACT [] synonym: "chondroitin sulfate B proteoglycan metabolism" EXACT [] synonym: "dermatan sulfate proteoglycan metabolism" EXACT [] synonym: "dermatan sulphate proteoglycan metabolic process" EXACT [] synonym: "dermatan sulphate proteoglycan metabolism" EXACT [] is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process [Term] id: GO:0050656 name: 3'-phosphoadenosine 5'-phosphosulfate binding namespace: molecular_function def: "Interacting selectively and non-covalently with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [GOC:ai] synonym: "3'-phosphoadenosine 5'-phosphosulphate binding" EXACT [] synonym: "3'-phosphoadenylyl-sulfate binding" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate binding" EXACT [] synonym: "PAPS binding" EXACT [] synonym: "phosphoadenosine phosphosulfate binding" EXACT [] is_a: GO:0030554 ! adenyl nucleotide binding [Term] id: GO:0050657 name: nucleic acid transport namespace: biological_process def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport [Term] id: GO:0050658 name: RNA transport namespace: biological_process def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050657 ! nucleic acid transport is_a: GO:0051236 ! establishment of RNA localization [Term] id: GO:0050659 name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.33] synonym: "3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity" EXACT [EC:2.8.2.33] synonym: "GalNAc4S-6ST" RELATED [EC:2.8.2.33] synonym: "N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity" EXACT [EC:2.8.2.33] xref: EC:2.8.2.33 xref: MetaCyc:RXN-7953 xref: MetaCyc:RXN-7954 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050660 name: flavin adenine dinucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "FAD or FADH2 binding" EXACT [] synonym: "flavine-adenine dinucleotide binding" EXACT [] is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0050661 name: NADP binding namespace: molecular_function def: "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] synonym: "NADP or NADPH binding" RELATED [GOC:mah] synonym: "NADP+ or NADPH binding" RELATED [] synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT [] is_a: GO:0000166 ! nucleotide binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0050662 name: coenzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0048037 ! cofactor binding [Term] id: GO:0050663 name: cytokine secretion namespace: biological_process def: "The regulated release of cytokines from a cell or group of cells. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] synonym: "interferon secretion" NARROW [GOC:add, GOC:mah] synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0001816 ! cytokine production [Term] id: GO:0050664 name: oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-] xref: EC:1.6.3 is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0050665 name: hydrogen peroxide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai] subset: gosubset_prok synonym: "H2O2 biosynthetic process" EXACT [GOc:mah] synonym: "hydrogen peroxide anabolism" EXACT [] synonym: "hydrogen peroxide biosynthesis" EXACT [] synonym: "hydrogen peroxide formation" EXACT [] synonym: "hydrogen peroxide generation" EXACT [] synonym: "hydrogen peroxide synthesis" EXACT [] is_a: GO:0042743 ! hydrogen peroxide metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0050666 name: regulation of homocysteine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "regulation of Hcy metabolic process" EXACT [] synonym: "regulation of Hcy metabolism" EXACT [] synonym: "regulation of homocysteine metabolism" EXACT [] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process relationship: regulates GO:0050667 ! homocysteine metabolic process [Term] id: GO:0050667 name: homocysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "Hcy metabolic process" EXACT [] synonym: "Hcy metabolism" EXACT [] synonym: "homocysteine metabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0050668 name: positive regulation of homocysteine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai] subset: gosubset_prok synonym: "activation of homocysteine metabolic process" NARROW [] synonym: "positive regulation of Hcy metabolic process" EXACT [] synonym: "positive regulation of Hcy metabolism" EXACT [] synonym: "positive regulation of homocysteine metabolism" EXACT [] synonym: "stimulation of homocysteine metabolic process" NARROW [] synonym: "up regulation of homocysteine metabolic process" EXACT [] synonym: "up-regulation of homocysteine metabolic process" EXACT [] synonym: "upregulation of homocysteine metabolic process" EXACT [] is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process is_a: GO:0050666 ! regulation of homocysteine metabolic process relationship: positively_regulates GO:0050667 ! homocysteine metabolic process [Term] id: GO:0050669 name: negative regulation of homocysteine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai] subset: gosubset_prok synonym: "down regulation of homocysteine metabolic process" EXACT [] synonym: "down-regulation of homocysteine metabolic process" EXACT [] synonym: "downregulation of homocysteine metabolic process" EXACT [] synonym: "inhibition of homocysteine metabolic process" NARROW [] synonym: "negative regulation of Hcy metabolic process" EXACT [] synonym: "negative regulation of Hcy metabolism" EXACT [] synonym: "negative regulation of homocysteine metabolism" EXACT [] is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process is_a: GO:0050666 ! regulation of homocysteine metabolic process relationship: negatively_regulates GO:0050667 ! homocysteine metabolic process [Term] id: GO:0050670 name: regulation of lymphocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0051249 ! regulation of lymphocyte activation relationship: regulates GO:0046651 ! lymphocyte proliferation [Term] id: GO:0050671 name: positive regulation of lymphocyte proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai] synonym: "activation of lymphocyte proliferation" NARROW [] synonym: "stimulation of lymphocyte proliferation" NARROW [] synonym: "up regulation of lymphocyte proliferation" EXACT [] synonym: "up-regulation of lymphocyte proliferation" EXACT [] synonym: "upregulation of lymphocyte proliferation" EXACT [] is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051251 ! positive regulation of lymphocyte activation relationship: positively_regulates GO:0046651 ! lymphocyte proliferation [Term] id: GO:0050672 name: negative regulation of lymphocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai] synonym: "down regulation of lymphocyte proliferation" EXACT [] synonym: "down-regulation of lymphocyte proliferation" EXACT [] synonym: "downregulation of lymphocyte proliferation" EXACT [] synonym: "inhibition of lymphocyte proliferation" NARROW [] is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051250 ! negative regulation of lymphocyte activation relationship: negatively_regulates GO:0046651 ! lymphocyte proliferation [Term] id: GO:0050673 name: epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0050674 name: urothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050675 name: regulation of urothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of urothelial cell proliferation." [GOC:ai] is_a: GO:0050678 ! regulation of epithelial cell proliferation relationship: regulates GO:0050674 ! urothelial cell proliferation [Term] id: GO:0050676 name: negative regulation of urothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation." [GOC:ai] synonym: "down regulation of urothelial cell proliferation" EXACT [] synonym: "down-regulation of urothelial cell proliferation" EXACT [] synonym: "downregulation of urothelial cell proliferation" EXACT [] synonym: "inhibition of urothelial cell proliferation" NARROW [] is_a: GO:0050675 ! regulation of urothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation relationship: negatively_regulates GO:0050674 ! urothelial cell proliferation [Term] id: GO:0050677 name: positive regulation of urothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of urothelial cell proliferation." [GOC:ai] synonym: "activation of urothelial cell proliferation" NARROW [] synonym: "stimulation of urothelial cell proliferation" NARROW [] synonym: "up regulation of urothelial cell proliferation" EXACT [] synonym: "up-regulation of urothelial cell proliferation" EXACT [] synonym: "upregulation of urothelial cell proliferation" EXACT [] is_a: GO:0050675 ! regulation of urothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation relationship: positively_regulates GO:0050674 ! urothelial cell proliferation [Term] id: GO:0050678 name: regulation of epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050679 name: positive regulation of epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "activation of epithelial cell proliferation" NARROW [] synonym: "stimulation of epithelial cell proliferation" NARROW [] synonym: "up regulation of epithelial cell proliferation" EXACT [] synonym: "up-regulation of epithelial cell proliferation" EXACT [] synonym: "upregulation of epithelial cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation relationship: positively_regulates GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050680 name: negative regulation of epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "down regulation of epithelial cell proliferation" EXACT [] synonym: "down-regulation of epithelial cell proliferation" EXACT [] synonym: "downregulation of epithelial cell proliferation" EXACT [] synonym: "inhibition of epithelial cell proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation relationship: negatively_regulates GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050681 name: androgen receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an androgen receptor." [GOC:ai] synonym: "AR binding" EXACT [] is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0050682 name: AF-2 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation." [PMID:9682036] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050683 name: AF-1 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor." [PMID:9682036] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050684 name: regulation of mRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] subset: gosubset_prok is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0006397 ! mRNA processing [Term] id: GO:0050685 name: positive regulation of mRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai] subset: gosubset_prok synonym: "activation of mRNA processing" NARROW [] synonym: "stimulation of mRNA processing" NARROW [] synonym: "up regulation of mRNA processing" EXACT [] synonym: "up-regulation of mRNA processing" EXACT [] synonym: "upregulation of mRNA processing" EXACT [] is_a: GO:0050684 ! regulation of mRNA processing is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0006397 ! mRNA processing [Term] id: GO:0050686 name: negative regulation of mRNA processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing." [GOC:ai] subset: gosubset_prok synonym: "down regulation of mRNA processing" EXACT [] synonym: "down-regulation of mRNA processing" EXACT [] synonym: "downregulation of mRNA processing" EXACT [] synonym: "inhibition of mRNA processing" NARROW [] is_a: GO:0050684 ! regulation of mRNA processing is_a: GO:0051253 ! negative regulation of RNA metabolic process relationship: negatively_regulates GO:0006397 ! mRNA processing [Term] id: GO:0050687 name: negative regulation of defense response to virus namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." [GOC:ai] synonym: "down regulation of antiviral response" EXACT [] synonym: "down-regulation of antiviral response" EXACT [] synonym: "downregulation of antiviral response" EXACT [] synonym: "inhibition of antiviral response" NARROW [] synonym: "negative regulation of antiviral response" EXACT [GOC:dph] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0050688 ! regulation of defense response to virus relationship: negatively_regulates GO:0051607 ! defense response to virus [Term] id: GO:0050688 name: regulation of defense response to virus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai] synonym: "regulation of antiviral response" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0051607 ! defense response to virus [Term] id: GO:0050689 name: negative regulation of defense response to virus by host namespace: biological_process def: "Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of antiviral response by host" EXACT [] synonym: "down-regulation of antiviral response by host" EXACT [] synonym: "downregulation of antiviral response by host" EXACT [] synonym: "inhibition of antiviral response by host" NARROW [] synonym: "negative regulation by host of antiviral response" EXACT [] synonym: "negative regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] is_a: GO:0050687 ! negative regulation of defense response to virus is_a: GO:0050691 ! regulation of defense response to virus by host [Term] id: GO:0050690 name: regulation of defense response to virus by virus namespace: biological_process def: "Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism." [GOC:ai, GOC:dph] synonym: "regulation by virus of antiviral response" EXACT [] synonym: "regulation of antiviral response by virus" EXACT [GOC:dph] synonym: "viral regulation of antiviral response" EXACT [] xref: Reactome:164938 "Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters" xref: Reactome:164939 "Nef mediated downregulation of CD28 cell surface expression" xref: Reactome:164940 "Nef mediated downregulation of MHC class I complex cell surface expression" xref: Reactome:164943 "Nef mediated activation of the T-cell receptor" xref: Reactome:164944 "Nef and signal transduction" xref: Reactome:167590 "Nef Mediated CD4 Down-regulation" xref: Reactome:182218 "Nef Mediated CD8 Down-regulation" is_a: GO:0050688 ! regulation of defense response to virus [Term] id: GO:0050691 name: regulation of defense response to virus by host namespace: biological_process def: "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism." [GOC:ai, GOC:dph] synonym: "host regulation of antiviral response" EXACT [] synonym: "regulation by host of antiviral response" EXACT [] synonym: "regulation of antiviral response by host" RELATED [GOC:dph] is_a: GO:0050688 ! regulation of defense response to virus [Term] id: GO:0050692 name: DBD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors." [PMID:9682036] synonym: "DNA binding domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050693 name: LBD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." [PMID:9682036] synonym: "ligand binding domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050694 name: galactose 3-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc." [GOC:ai, PMID:11323440, PMID:11356829] synonym: "Gal-3-O-sulfotransferase activity" EXACT [] synonym: "galactose 3-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050695 name: benzoylformate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2." [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN] subset: gosubset_prok synonym: "benzoylformate carboxy-lyase (benzaldehyde-forming)" EXACT [EC:4.1.1.7] synonym: "benzoylformate carboxy-lyase activity" EXACT [EC:4.1.1.7] synonym: "phenylglyoxylate decarboxylase activity" EXACT [] xref: EC:4.1.1.7 xref: MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN xref: UM-BBD_reactionID:r1049 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050696 name: trichloroethylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:ai] subset: gosubset_prok synonym: "trichloroethene catabolic process" EXACT [] synonym: "trichloroethene catabolism" EXACT [] synonym: "trichloroethylene breakdown" EXACT [] synonym: "trichloroethylene catabolism" EXACT [] synonym: "trichloroethylene degradation" EXACT [] is_a: GO:0018979 ! trichloroethylene metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process [Term] id: GO:0050697 name: 1,1,2-trichloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene." [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271] synonym: "1,1,2-trichloroethylene reductive dehalogenase activity" EXACT [] synonym: "TCE-reductive dehalogenase activity" EXACT [] xref: MetaCyc:TCEREDCHLOR-RXN xref: UM-BBD_enzymeID:e0271 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0050698 name: proteoglycan sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans." [EC:2.8.2.-, GOC:ai] synonym: "proteoglycan sulfate transfer" RELATED [] synonym: "proteoglycan sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050699 name: WW domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050700 name: CARD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050701 name: interleukin-1 secretion namespace: biological_process def: "The regulated release of interleukin-1 from a cell or group of cells. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "IL-1 secretion" EXACT [] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032612 ! interleukin-1 production [Term] id: GO:0050702 name: interleukin-1 beta secretion namespace: biological_process def: "The regulated release of interleukin 1 beta from a cell or group of cells." [GOC:ai] synonym: "IL-1b secretion" EXACT [] is_a: GO:0050701 ! interleukin-1 secretion relationship: part_of GO:0032611 ! interleukin-1 beta production [Term] id: GO:0050703 name: interleukin-1 alpha secretion namespace: biological_process def: "The regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai] synonym: "IL-1a secretion" EXACT [] is_a: GO:0050701 ! interleukin-1 secretion relationship: part_of GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0050704 name: regulation of interleukin-1 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells." [GOC:ai] is_a: GO:0032652 ! regulation of interleukin-1 production is_a: GO:0050707 ! regulation of cytokine secretion relationship: regulates GO:0050701 ! interleukin-1 secretion [Term] id: GO:0050705 name: regulation of interleukin-1 alpha secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0050704 ! regulation of interleukin-1 secretion relationship: regulates GO:0050703 ! interleukin-1 alpha secretion [Term] id: GO:0050706 name: regulation of interleukin-1 beta secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells." [GOC:ai] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0050704 ! regulation of interleukin-1 secretion relationship: regulates GO:0050702 ! interleukin-1 beta secretion [Term] id: GO:0050707 name: regulation of cytokine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells." [GOC:ai] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0050708 ! regulation of protein secretion relationship: regulates GO:0050663 ! cytokine secretion [Term] id: GO:0050708 name: regulation of protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell or group of cells." [GOC:ai] subset: gosubset_prok is_a: GO:0051046 ! regulation of secretion is_a: GO:0051223 ! regulation of protein transport is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0009306 ! protein secretion [Term] id: GO:0050709 name: negative regulation of protein secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell or group of cells." [GOC:ai] synonym: "down regulation of protein secretion" EXACT [] synonym: "down-regulation of protein secretion" EXACT [] synonym: "downregulation of protein secretion" EXACT [] synonym: "inhibition of protein secretion" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051224 ! negative regulation of protein transport relationship: negatively_regulates GO:0009306 ! protein secretion [Term] id: GO:0050710 name: negative regulation of cytokine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells." [GOC:ai] synonym: "down regulation of cytokine secretion" EXACT [] synonym: "down-regulation of cytokine secretion" EXACT [] synonym: "downregulation of cytokine secretion" EXACT [] synonym: "inhibition of cytokine secretion" NARROW [] is_a: GO:0050707 ! regulation of cytokine secretion is_a: GO:0050709 ! negative regulation of protein secretion relationship: negatively_regulates GO:0050663 ! cytokine secretion [Term] id: GO:0050711 name: negative regulation of interleukin-1 secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells." [GOC:ai] synonym: "down regulation of interleukin-1 secretion" EXACT [] synonym: "down-regulation of interleukin-1 secretion" EXACT [] synonym: "downregulation of interleukin-1 secretion" EXACT [] synonym: "inhibition of interleukin-1 secretion" NARROW [] is_a: GO:0032692 ! negative regulation of interleukin-1 production is_a: GO:0050704 ! regulation of interleukin-1 secretion is_a: GO:0050710 ! negative regulation of cytokine secretion relationship: negatively_regulates GO:0050701 ! interleukin-1 secretion [Term] id: GO:0050712 name: negative regulation of interleukin-1 alpha secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai] synonym: "down regulation of interleukin-1 alpha secretion" EXACT [] synonym: "down-regulation of interleukin-1 alpha secretion" EXACT [] synonym: "downregulation of interleukin-1 alpha secretion" EXACT [] synonym: "inhibition of interleukin-1 alpha secretion" NARROW [] is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion is_a: GO:0050711 ! negative regulation of interleukin-1 secretion relationship: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion [Term] id: GO:0050713 name: negative regulation of interleukin-1 beta secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells." [GOC:ai] synonym: "down regulation of interleukin-1 beta secretion" EXACT [] synonym: "down-regulation of interleukin-1 beta secretion" EXACT [] synonym: "downregulation of interleukin-1 beta secretion" EXACT [] synonym: "inhibition of interleukin-1 beta secretion" NARROW [] is_a: GO:0032691 ! negative regulation of interleukin-1 beta production is_a: GO:0050706 ! regulation of interleukin-1 beta secretion is_a: GO:0050711 ! negative regulation of interleukin-1 secretion relationship: negatively_regulates GO:0050702 ! interleukin-1 beta secretion [Term] id: GO:0050714 name: positive regulation of protein secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell or group of cells." [GOC:ai] synonym: "activation of protein secretion" NARROW [] synonym: "stimulation of protein secretion" NARROW [] synonym: "up regulation of protein secretion" EXACT [] synonym: "up-regulation of protein secretion" EXACT [] synonym: "upregulation of protein secretion" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051222 ! positive regulation of protein transport relationship: positively_regulates GO:0009306 ! protein secretion [Term] id: GO:0050715 name: positive regulation of cytokine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells." [GOC:ai] synonym: "activation of cytokine secretion" NARROW [] synonym: "stimulation of cytokine secretion" NARROW [] synonym: "up regulation of cytokine secretion" EXACT [] synonym: "up-regulation of cytokine secretion" EXACT [] synonym: "upregulation of cytokine secretion" EXACT [] is_a: GO:0050707 ! regulation of cytokine secretion is_a: GO:0050714 ! positive regulation of protein secretion relationship: positively_regulates GO:0050663 ! cytokine secretion [Term] id: GO:0050716 name: positive regulation of interleukin-1 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells." [GOC:ai] synonym: "activation of interleukin-1 secretion" NARROW [] synonym: "stimulation of interleukin-1 secretion" NARROW [] synonym: "up regulation of interleukin-1 secretion" EXACT [] synonym: "up-regulation of interleukin-1 secretion" EXACT [] synonym: "upregulation of interleukin-1 secretion" EXACT [] is_a: GO:0032732 ! positive regulation of interleukin-1 production is_a: GO:0050704 ! regulation of interleukin-1 secretion is_a: GO:0050715 ! positive regulation of cytokine secretion relationship: positively_regulates GO:0050701 ! interleukin-1 secretion [Term] id: GO:0050717 name: positive regulation of interleukin-1 alpha secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai] synonym: "activation of interleukin-1 alpha secretion" NARROW [] synonym: "stimulation of interleukin-1 alpha secretion" NARROW [] synonym: "up regulation of interleukin-1 alpha secretion" EXACT [] synonym: "up-regulation of interleukin-1 alpha secretion" EXACT [] synonym: "upregulation of interleukin-1 alpha secretion" EXACT [] is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion is_a: GO:0050716 ! positive regulation of interleukin-1 secretion relationship: positively_regulates GO:0050703 ! interleukin-1 alpha secretion [Term] id: GO:0050718 name: positive regulation of interleukin-1 beta secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells." [GOC:ai] synonym: "activation of interleukin-1 beta secretion" NARROW [] synonym: "stimulation of interleukin-1 beta secretion" NARROW [] synonym: "up regulation of interleukin-1 beta secretion" EXACT [] synonym: "up-regulation of interleukin-1 beta secretion" EXACT [] synonym: "upregulation of interleukin-1 beta secretion" EXACT [] is_a: GO:0032731 ! positive regulation of interleukin-1 beta production is_a: GO:0050706 ! regulation of interleukin-1 beta secretion is_a: GO:0050716 ! positive regulation of interleukin-1 secretion relationship: positively_regulates GO:0050702 ! interleukin-1 beta secretion [Term] id: GO:0050719 name: interleukin-1 alpha biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] synonym: "interleukin-1 alpha anabolism" EXACT [] synonym: "interleukin-1 alpha biosynthesis" EXACT [] synonym: "interleukin-1 alpha formation" EXACT [] synonym: "interleukin-1 alpha synthesis" EXACT [] is_a: GO:0042222 ! interleukin-1 biosynthetic process relationship: part_of GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0050720 name: interleukin-1 beta biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] synonym: "interleukin-1 beta anabolism" EXACT [] synonym: "interleukin-1 beta biosynthesis" EXACT [] synonym: "interleukin-1 beta formation" EXACT [] synonym: "interleukin-1 beta synthesis" EXACT [] is_a: GO:0042222 ! interleukin-1 biosynthetic process relationship: part_of GO:0032611 ! interleukin-1 beta production [Term] id: GO:0050721 name: regulation of interleukin-1 alpha biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] synonym: "regulation of interleukin-1 alpha anabolism" EXACT [] synonym: "regulation of interleukin-1 alpha biosynthesis" EXACT [] synonym: "regulation of interleukin-1 alpha formation" EXACT [] synonym: "regulation of interleukin-1 alpha synthesis" EXACT [] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process relationship: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process [Term] id: GO:0050722 name: regulation of interleukin-1 beta biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] synonym: "regulation of interleukin-1 beta anabolism" EXACT [] synonym: "regulation of interleukin-1 beta biosynthesis" EXACT [] synonym: "regulation of interleukin-1 beta formation" EXACT [] synonym: "regulation of interleukin-1 beta synthesis" EXACT [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process relationship: regulates GO:0050720 ! interleukin-1 beta biosynthetic process [Term] id: GO:0050723 name: negative regulation of interleukin-1 alpha biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] synonym: "down regulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "downregulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "inhibition of interleukin-1 alpha biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-1 alpha anabolism" EXACT [] synonym: "negative regulation of interleukin-1 alpha biosynthesis" EXACT [] synonym: "negative regulation of interleukin-1 alpha formation" EXACT [] synonym: "negative regulation of interleukin-1 alpha synthesis" EXACT [] is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process relationship: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process [Term] id: GO:0050724 name: negative regulation of interleukin-1 beta biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] synonym: "down regulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "downregulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "inhibition of interleukin-1 beta biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-1 beta anabolism" EXACT [] synonym: "negative regulation of interleukin-1 beta biosynthesis" EXACT [] synonym: "negative regulation of interleukin-1 beta formation" EXACT [] synonym: "negative regulation of interleukin-1 beta synthesis" EXACT [] is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process relationship: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process [Term] id: GO:0050725 name: positive regulation of interleukin-1 beta biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] synonym: "activation of interleukin-1 beta biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-1 beta anabolism" EXACT [] synonym: "positive regulation of interleukin-1 beta biosynthesis" EXACT [] synonym: "positive regulation of interleukin-1 beta formation" EXACT [] synonym: "positive regulation of interleukin-1 beta synthesis" EXACT [] synonym: "stimulation of interleukin-1 beta biosynthetic process" NARROW [] synonym: "up regulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "upregulation of interleukin-1 beta biosynthetic process" EXACT [] is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process relationship: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process [Term] id: GO:0050726 name: positive regulation of interleukin-1 alpha biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] synonym: "activation of interleukin-1 alpha biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-1 alpha anabolism" EXACT [] synonym: "positive regulation of interleukin-1 alpha biosynthesis" EXACT [] synonym: "positive regulation of interleukin-1 alpha formation" EXACT [] synonym: "positive regulation of interleukin-1 alpha synthesis" EXACT [] synonym: "stimulation of interleukin-1 alpha biosynthetic process" NARROW [] synonym: "up regulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "upregulation of interleukin-1 alpha biosynthetic process" EXACT [] is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process relationship: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process [Term] id: GO:0050727 name: regulation of inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai] is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus relationship: regulates GO:0006954 ! inflammatory response [Term] id: GO:0050728 name: negative regulation of inflammatory response namespace: biological_process alt_id: GO:0030236 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "anti-inflammatory response" EXACT [] synonym: "down regulation of inflammatory response" EXACT [] synonym: "down-regulation of inflammatory response" EXACT [] synonym: "downregulation of inflammatory response" EXACT [] synonym: "inhibition of inflammatory response" NARROW [] is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response relationship: negatively_regulates GO:0006954 ! inflammatory response [Term] id: GO:0050729 name: positive regulation of inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "activation of inflammatory response" NARROW [] synonym: "stimulation of inflammatory response" NARROW [] synonym: "up regulation of inflammatory response" EXACT [] synonym: "up-regulation of inflammatory response" EXACT [] synonym: "upregulation of inflammatory response" EXACT [] is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response relationship: positively_regulates GO:0006954 ! inflammatory response [Term] id: GO:0050730 name: regulation of peptidyl-tyrosine phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] subset: gosubset_prok is_a: GO:0001932 ! regulation of protein phosphorylation relationship: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation [Term] id: GO:0050731 name: positive regulation of peptidyl-tyrosine phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] subset: gosubset_prok synonym: "activation of peptidyl-tyrosine phosphorylation" NARROW [] synonym: "stimulation of peptidyl-tyrosine phosphorylation" NARROW [] synonym: "up regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "up-regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "upregulation of peptidyl-tyrosine phosphorylation" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation relationship: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation [Term] id: GO:0050732 name: negative regulation of peptidyl-tyrosine phosphorylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] subset: gosubset_prok synonym: "down regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "down-regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "downregulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "inhibition of peptidyl-tyrosine phosphorylation" NARROW [] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation relationship: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation [Term] id: GO:0050733 name: RS domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing." [PMID:11684676, PMID:12215544] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050734 name: hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule." [GOC:ai] is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0050735 name: N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0016420 ! malonyltransferase activity [Term] id: GO:0050736 name: O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016420 ! malonyltransferase activity [Term] id: GO:0050737 name: O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0050734 ! hydroxycinnamoyltransferase activity [Term] id: GO:0050738 name: fructosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050739 name: peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium namespace: biological_process def: "The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [RESID:AA0348] subset: gosubset_prok xref: RESID:AA0348 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018206 ! peptidyl-methionine modification is_a: GO:0018211 ! peptidyl-tryptophan modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0050740 name: protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine namespace: biological_process def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine." [RESID:AA0349] subset: gosubset_prok xref: RESID:AA0349 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050741 name: protein-FMN linkage via O3-riboflavin phosphoryl-L-serine namespace: biological_process def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine." [RESID:AA0350] subset: gosubset_prok xref: RESID:AA0350 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050742 name: protein-FMN linkage via S-(4a-FMN)-L-cysteine namespace: biological_process def: "The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine." [RESID:AA0351] subset: gosubset_prok xref: RESID:AA0351 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050743 name: protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine namespace: biological_process def: "The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine." [PMID:8611516, RESID:AA0352] subset: gosubset_prok xref: RESID:AA0352 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050744 name: protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine namespace: biological_process def: "The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine." [RESID:AA0353] subset: gosubset_prok xref: RESID:AA0353 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050745 name: peptide cross-linking via L-cysteinyl-5-imidazolinone glycine namespace: biological_process def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0188] subset: gosubset_prok xref: RESID:AA0188 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine [Term] id: GO:0050746 name: regulation of lipoprotein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] subset: gosubset_prok synonym: "regulation of lipoprotein metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0050747 name: positive regulation of lipoprotein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] subset: gosubset_prok synonym: "activation of lipoprotein metabolic process" NARROW [] synonym: "positive regulation of lipoprotein metabolism" EXACT [] synonym: "stimulation of lipoprotein metabolic process" NARROW [] synonym: "up regulation of lipoprotein metabolic process" EXACT [] synonym: "up-regulation of lipoprotein metabolic process" EXACT [] synonym: "upregulation of lipoprotein metabolic process" EXACT [] is_a: GO:0032270 ! positive regulation of cellular protein metabolic process is_a: GO:0050746 ! regulation of lipoprotein metabolic process relationship: positively_regulates GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0050748 name: negative regulation of lipoprotein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] subset: gosubset_prok synonym: "down regulation of lipoprotein metabolic process" EXACT [] synonym: "down-regulation of lipoprotein metabolic process" EXACT [] synonym: "downregulation of lipoprotein metabolic process" EXACT [] synonym: "inhibition of lipoprotein metabolic process" NARROW [] synonym: "negative regulation of lipoprotein metabolism" EXACT [] is_a: GO:0032269 ! negative regulation of cellular protein metabolic process is_a: GO:0050746 ! regulation of lipoprotein metabolic process relationship: negatively_regulates GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0050749 name: apolipoprotein E receptor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with an apolipoprotein E receptor." [GOC:ai] comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid). is_obsolete: true replaced_by: GO:0070326 [Term] id: GO:0050750 name: low-density lipoprotein particle receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a low-density lipoprotein receptor." [GOC:ai] synonym: "LDL receptor binding" EXACT [] synonym: "low-density lipoprotein receptor binding" EXACT [GOC:dph] is_a: GO:0070325 ! lipoprotein particle receptor binding [Term] id: GO:0050751 name: fractalkine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de] synonym: "ABCD-3 biosynthesis" EXACT [] synonym: "ABCD-3 biosynthetic process" EXACT [] synonym: "CX3C membrane-anchored chemokine biosynthesis" EXACT [] synonym: "CX3C membrane-anchored chemokine biosynthetic process" EXACT [] synonym: "CX3CL1 biosynthesis" EXACT [] synonym: "CX3CL1 biosynthetic process" EXACT [] synonym: "fractalkine anabolism" EXACT [] synonym: "fractalkine biosynthesis" EXACT [] synonym: "fractalkine formation" EXACT [] synonym: "fractalkine synthesis" EXACT [] synonym: "neurotactin biosynthesis" EXACT [] synonym: "neurotactin biosynthetic process" EXACT [] is_a: GO:0042033 ! chemokine biosynthetic process is_a: GO:0050756 ! fractalkine metabolic process relationship: part_of GO:0032603 ! fractalkine production [Term] id: GO:0050752 name: regulation of fractalkine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] synonym: "regulation of CX3CL1 biosynthesis" EXACT [] synonym: "regulation of CX3CL1 biosynthetic process" EXACT [] synonym: "regulation of fractalkine anabolism" EXACT [] synonym: "regulation of fractalkine biosynthesis" EXACT [] synonym: "regulation of fractalkine formation" EXACT [] synonym: "regulation of fractalkine synthesis" EXACT [] synonym: "regulation of neurotactin biosynthesis" EXACT [] synonym: "regulation of neurotactin biosynthetic process" EXACT [] is_a: GO:0032644 ! regulation of fractalkine production is_a: GO:0045073 ! regulation of chemokine biosynthetic process relationship: regulates GO:0050751 ! fractalkine biosynthetic process [Term] id: GO:0050753 name: negative regulation of fractalkine biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] synonym: "down regulation of fractalkine biosynthetic process" EXACT [] synonym: "down-regulation of fractalkine biosynthetic process" EXACT [] synonym: "downregulation of fractalkine biosynthetic process" EXACT [] synonym: "inhibition of fractalkine biosynthetic process" NARROW [] synonym: "negative regulation of CX3CL1 biosynthesis" EXACT [] synonym: "negative regulation of CX3CL1 biosynthetic process" EXACT [] synonym: "negative regulation of fractalkine anabolism" EXACT [] synonym: "negative regulation of fractalkine biosynthesis" EXACT [] synonym: "negative regulation of fractalkine formation" EXACT [] synonym: "negative regulation of fractalkine synthesis" EXACT [] synonym: "negative regulation of neurotactin biosynthesis" EXACT [] synonym: "negative regulation of neurotactin biosynthetic process" EXACT [] is_a: GO:0045079 ! negative regulation of chemokine biosynthetic process is_a: GO:0050752 ! regulation of fractalkine biosynthetic process relationship: negatively_regulates GO:0050751 ! fractalkine biosynthetic process [Term] id: GO:0050754 name: positive regulation of fractalkine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] synonym: "activation of fractalkine biosynthetic process" NARROW [] synonym: "positive regulation of CX3CL1 biosynthesis" EXACT [] synonym: "positive regulation of CX3CL1 biosynthetic process" EXACT [] synonym: "positive regulation of fractalkine anabolism" EXACT [] synonym: "positive regulation of fractalkine biosynthesis" EXACT [] synonym: "positive regulation of fractalkine formation" EXACT [] synonym: "positive regulation of fractalkine synthesis" EXACT [] synonym: "positive regulation of neurotactin biosynthesis" EXACT [] synonym: "positive regulation of neurotactin biosynthetic process" EXACT [] synonym: "stimulation of fractalkine biosynthetic process" NARROW [] synonym: "up regulation of fractalkine biosynthetic process" EXACT [] synonym: "up-regulation of fractalkine biosynthetic process" EXACT [] synonym: "upregulation of fractalkine biosynthetic process" EXACT [] is_a: GO:0045080 ! positive regulation of chemokine biosynthetic process is_a: GO:0050752 ! regulation of fractalkine biosynthetic process relationship: positively_regulates GO:0050751 ! fractalkine biosynthetic process [Term] id: GO:0050755 name: chemokine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "chemokine metabolism" EXACT [] is_a: GO:0042107 ! cytokine metabolic process [Term] id: GO:0050756 name: fractalkine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de] synonym: "ABCD-3 metabolic process" EXACT [] synonym: "ABCD-3 metabolism" EXACT [] synonym: "CX3C membrane-anchored chemokine metabolic process" EXACT [] synonym: "CX3C membrane-anchored chemokine metabolism" EXACT [] synonym: "CX3CL1 metabolic process" EXACT [] synonym: "CX3CL1 metabolism" EXACT [] synonym: "fractalkine metabolism" EXACT [] synonym: "neurotactin metabolic process" EXACT [] synonym: "neurotactin metabolism" EXACT [] is_a: GO:0050755 ! chemokine metabolic process [Term] id: GO:0050757 name: thymidylate synthase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45] subset: gosubset_prok synonym: "thymidylate synthase anabolism" EXACT [] synonym: "thymidylate synthase biosynthesis" EXACT [] synonym: "thymidylate synthase formation" EXACT [] synonym: "thymidylate synthase synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0050758 name: regulation of thymidylate synthase biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] subset: gosubset_prok synonym: "regulation of thymidylate synthase anabolism" EXACT [] synonym: "regulation of thymidylate synthase biosynthesis" EXACT [] synonym: "regulation of thymidylate synthase formation" EXACT [] synonym: "regulation of thymidylate synthase synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process relationship: regulates GO:0050757 ! thymidylate synthase biosynthetic process [Term] id: GO:0050759 name: positive regulation of thymidylate synthase biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] subset: gosubset_prok synonym: "activation of thymidylate synthase biosynthetic process" NARROW [] synonym: "positive regulation of thymidylate synthase anabolism" EXACT [] synonym: "positive regulation of thymidylate synthase biosynthesis" EXACT [] synonym: "positive regulation of thymidylate synthase formation" EXACT [] synonym: "positive regulation of thymidylate synthase synthesis" EXACT [] synonym: "stimulation of thymidylate synthase biosynthetic process" NARROW [] synonym: "up regulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "up-regulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "upregulation of thymidylate synthase biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process relationship: positively_regulates GO:0050757 ! thymidylate synthase biosynthetic process [Term] id: GO:0050760 name: negative regulation of thymidylate synthase biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] subset: gosubset_prok synonym: "down regulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "down-regulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "downregulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "inhibition of thymidylate synthase biosynthetic process" NARROW [] synonym: "negative regulation of thymidylate synthase anabolism" EXACT [] synonym: "negative regulation of thymidylate synthase biosynthesis" EXACT [] synonym: "negative regulation of thymidylate synthase formation" EXACT [] synonym: "negative regulation of thymidylate synthase synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process relationship: negatively_regulates GO:0050757 ! thymidylate synthase biosynthetic process [Term] id: GO:0050761 name: depsipeptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "depsipeptide metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process [Term] id: GO:0050762 name: depsipeptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] subset: gosubset_prok synonym: "depsipeptide breakdown" EXACT [] synonym: "depsipeptide catabolism" EXACT [] synonym: "depsipeptide degradation" EXACT [] is_a: GO:0043171 ! peptide catabolic process is_a: GO:0050761 ! depsipeptide metabolic process [Term] id: GO:0050763 name: depsipeptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] subset: gosubset_prok synonym: "depsipeptide anabolism" EXACT [] synonym: "depsipeptide biosynthesis" EXACT [] synonym: "depsipeptide formation" EXACT [] synonym: "depsipeptide synthesis" EXACT [] is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0050761 ! depsipeptide metabolic process [Term] id: GO:0050764 name: regulation of phagocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai] is_a: GO:0030100 ! regulation of endocytosis relationship: regulates GO:0006909 ! phagocytosis [Term] id: GO:0050765 name: negative regulation of phagocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai] synonym: "down regulation of phagocytosis" EXACT [] synonym: "down-regulation of phagocytosis" EXACT [] synonym: "downregulation of phagocytosis" EXACT [] synonym: "inhibition of phagocytosis" NARROW [] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:0050764 ! regulation of phagocytosis relationship: negatively_regulates GO:0006909 ! phagocytosis [Term] id: GO:0050766 name: positive regulation of phagocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai] synonym: "activation of phagocytosis" NARROW [] synonym: "stimulation of phagocytosis" NARROW [] synonym: "up regulation of phagocytosis" EXACT [] synonym: "up-regulation of phagocytosis" EXACT [] synonym: "upregulation of phagocytosis" EXACT [] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:0050764 ! regulation of phagocytosis relationship: positively_regulates GO:0006909 ! phagocytosis [Term] id: GO:0050767 name: regulation of neurogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060284 ! regulation of cell development relationship: part_of GO:0048699 ! generation of neurons relationship: regulates GO:0022008 ! neurogenesis [Term] id: GO:0050768 name: negative regulation of neurogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai] synonym: "down regulation of neurogenesis" EXACT [] synonym: "down-regulation of neurogenesis" EXACT [] synonym: "downregulation of neurogenesis" EXACT [] synonym: "inhibition of neurogenesis" NARROW [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis relationship: negatively_regulates GO:0022008 ! neurogenesis [Term] id: GO:0050769 name: positive regulation of neurogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai] synonym: "activation of neurogenesis" NARROW [] synonym: "stimulation of neurogenesis" NARROW [] synonym: "up regulation of neurogenesis" EXACT [] synonym: "up-regulation of neurogenesis" EXACT [] synonym: "upregulation of neurogenesis" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis relationship: positively_regulates GO:0022008 ! neurogenesis [Term] id: GO:0050770 name: regulation of axonogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] xref: Reactome:1253478 "p75NTR regulates axonogenesis" xref: Reactome:1280421 "p75NTR regulates axonogenesis" xref: Reactome:1299250 "p75NTR regulates axonogenesis" xref: Reactome:1326994 "p75NTR regulates axonogenesis" xref: Reactome:1353089 "p75NTR regulates axonogenesis" xref: Reactome:1373277 "p75NTR regulates axonogenesis" xref: Reactome:1393302 "p75NTR regulates axonogenesis" xref: Reactome:1417790 "p75NTR regulates axonogenesis" xref: Reactome:1450890 "p75NTR regulates axonogenesis" xref: Reactome:1471284 "p75NTR regulates axonogenesis" xref: Reactome:1483257 "p75NTR regulates axonogenesis" xref: Reactome:193697 "p75NTR regulates axonogenesis" is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0010975 ! regulation of neuron projection development relationship: regulates GO:0007409 ! axonogenesis [Term] id: GO:0050771 name: negative regulation of axonogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "down regulation of axonogenesis" EXACT [] synonym: "down-regulation of axonogenesis" EXACT [] synonym: "downregulation of axonogenesis" EXACT [] synonym: "inhibition of axonogenesis" NARROW [] xref: Reactome:1253477 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1280429 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1299249 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1326993 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1353088 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1373276 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1393301 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1417789 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1450889 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1471283 "Axonal growth inhibition (RHOA activation)" xref: Reactome:1483256 "Axonal growth inhibition (RHOA activation)" xref: Reactome:193634 "Axonal growth inhibition (RHOA activation)" is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:0050770 ! regulation of axonogenesis relationship: negatively_regulates GO:0007409 ! axonogenesis [Term] id: GO:0050772 name: positive regulation of axonogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "activation of axonogenesis" NARROW [] synonym: "stimulation of axonogenesis" NARROW [] synonym: "up regulation of axonogenesis" EXACT [] synonym: "up-regulation of axonogenesis" EXACT [] synonym: "upregulation of axonogenesis" EXACT [] xref: Reactome:1253484 "Axonal growth stimulation" xref: Reactome:1280420 "Axonal growth stimulation" xref: Reactome:1299272 "Axonal growth stimulation" xref: Reactome:1327000 "Axonal growth stimulation" xref: Reactome:1373283 "Axonal growth stimulation" xref: Reactome:1417796 "Axonal growth stimulation" xref: Reactome:1471290 "Axonal growth stimulation" xref: Reactome:1483263 "Axonal growth stimulation" xref: Reactome:209563 "Axonal growth stimulation" is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:0050770 ! regulation of axonogenesis relationship: positively_regulates GO:0007409 ! axonogenesis [Term] id: GO:0050773 name: regulation of dendrite development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] is_a: GO:0010975 ! regulation of neuron projection development relationship: regulates GO:0016358 ! dendrite development [Term] id: GO:0050774 name: negative regulation of dendrite morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] synonym: "down regulation of dendrite morphogenesis" EXACT [] synonym: "down-regulation of dendrite morphogenesis" EXACT [] synonym: "downregulation of dendrite morphogenesis" EXACT [] synonym: "inhibition of dendrite morphogenesis" NARROW [] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:0050768 ! negative regulation of neurogenesis relationship: negatively_regulates GO:0048813 ! dendrite morphogenesis [Term] id: GO:0050775 name: positive regulation of dendrite morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] synonym: "activation of dendrite morphogenesis" NARROW [] synonym: "stimulation of dendrite morphogenesis" NARROW [] synonym: "up regulation of dendrite morphogenesis" EXACT [] synonym: "up-regulation of dendrite morphogenesis" EXACT [] synonym: "upregulation of dendrite morphogenesis" EXACT [] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:0050769 ! positive regulation of neurogenesis relationship: positively_regulates GO:0048813 ! dendrite morphogenesis [Term] id: GO:0050776 name: regulation of immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] xref: Reactome:1253525 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" xref: Reactome:1280464 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" xref: Reactome:1299289 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" xref: Reactome:1327042 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" xref: Reactome:1353136 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" xref: Reactome:1373316 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" xref: Reactome:1393336 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" xref: Reactome:1417834 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" xref: Reactome:1450926 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" xref: Reactome:198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0006955 ! immune response [Term] id: GO:0050777 name: negative regulation of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "down regulation of immune response" EXACT [] synonym: "down-regulation of immune response" EXACT [] synonym: "downregulation of immune response" EXACT [] synonym: "inhibition of immune response" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response relationship: negatively_regulates GO:0006955 ! immune response [Term] id: GO:0050778 name: positive regulation of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "stimulation of immune response" NARROW [] synonym: "up regulation of immune response" EXACT [] synonym: "up-regulation of immune response" EXACT [] synonym: "upregulation of immune response" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response relationship: positively_regulates GO:0006955 ! immune response [Term] id: GO:0050779 name: RNA destabilization namespace: biological_process def: "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai] subset: gosubset_prok is_a: GO:0043487 ! regulation of RNA stability [Term] id: GO:0050780 name: dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a dopamine receptor." [GOC:ai] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0050781 name: ortho-trichlorophenol reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl." [GOC:ai, PMID:12697029] subset: gosubset_prok synonym: "2,4,6-TCP reductive dehalogenase activity" EXACT [] synonym: "2,4,6-trichlorophenol reductive dehalogenase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0050782 name: galactose uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6] synonym: "galactose, glucose uniporter activity" BROAD [] is_a: GO:0005354 ! galactose transmembrane transporter activity is_a: GO:0008516 ! hexose uniporter activity [Term] id: GO:0050783 name: cocaine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cocaine metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0046448 ! tropane alkaloid metabolic process [Term] id: GO:0050784 name: cocaine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cocaine breakdown" EXACT [] synonym: "cocaine catabolism" EXACT [] synonym: "cocaine degradation" EXACT [] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0050783 ! cocaine metabolic process [Term] id: GO:0050785 name: advanced glycation end-product receptor activity namespace: molecular_function def: "Combining with advanced glycation end-products to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins)." [PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812, Wikipedia:RAGE_(receptor)] synonym: "AGE receptor activity" EXACT [PMID:21590515] synonym: "RAGE activity" EXACT [PMID:21590515] is_a: GO:0004872 ! receptor activity [Term] id: GO:0050786 name: RAGE receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products." [GOC:ai] synonym: "advanced glycation end-product receptor binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0050787 name: detoxification of mercury ion namespace: biological_process def: "Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0])." [PMID:10774920] subset: gosubset_prok is_a: GO:0009636 ! response to toxin is_a: GO:0046689 ! response to mercury ion [Term] id: GO:0050788 name: sequestering of mercury namespace: biological_process def: "The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system." [PMID:10774920] synonym: "mercuric ion (Hg2+) sequestering" EXACT [] synonym: "mercuric ion (Hg2+) sequestration" EXACT [] synonym: "mercury (Hg) ion sequestering" EXACT [] synonym: "mercury (Hg) ion sequestration" EXACT [] synonym: "mercury (Hg2+) ion retention" EXACT [] synonym: "mercury (Hg2+) ion storage" EXACT [] synonym: "retention of mercury (Hg2+) ion" EXACT [] synonym: "sequestering of mercuric ion (Hg2+)" EXACT [] synonym: "sequestering of mercury (Hg) ion" EXACT [] synonym: "sequestration of mercuric ion (Hg2+)" EXACT [] synonym: "sequestration of mercury (Hg) ion" EXACT [] synonym: "storage of mercury (Hg2+) ion" EXACT [] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0050787 ! detoxification of mercury ion [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process alt_id: GO:0050791 def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: gosubset_prok synonym: "regulation of physiological process" EXACT [] is_a: GO:0065007 ! biological regulation relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process def: "Any process that modulates the activity of an enzyme." [GOC:ai] subset: gosubset_prok synonym: "regulation of enzyme activity" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0050792 name: regulation of viral reproduction namespace: biological_process def: "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb] synonym: "regulation of viral life cycle" EXACT [GOC:tb] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0016032 ! viral reproduction [Term] id: GO:0050793 name: regulation of developmental process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0032502 ! developmental process [Term] id: GO:0050794 name: regulation of cellular process namespace: biological_process alt_id: GO:0051244 def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of cellular physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0009987 ! cellular process [Term] id: GO:0050795 name: regulation of behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of behaviour" EXACT [] is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0007610 ! behavior [Term] id: GO:0050796 name: regulation of insulin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai] xref: Reactome:1253327 "Regulation of Insulin Secretion" xref: Reactome:1253665 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:1280265 "Regulation of Insulin Secretion" xref: Reactome:1280596 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:1299120 "Regulation of Insulin Secretion" xref: Reactome:1299426 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:1326843 "Regulation of Insulin Secretion" xref: Reactome:1327182 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:1352936 "Regulation of Insulin Secretion" xref: Reactome:1353277 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:1373143 "Regulation of Insulin Secretion" xref: Reactome:1373451 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:1393159 "Regulation of Insulin Secretion" xref: Reactome:1393476 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:1417644 "Regulation of Insulin Secretion" xref: Reactome:1417976 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:1450745 "Regulation of Insulin Secretion" xref: Reactome:1451062 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:1471186 "Regulation of Insulin Secretion" xref: Reactome:1483178 "Regulation of Insulin Secretion" xref: Reactome:1521133 "Regulation of Insulin Secretion" xref: Reactome:1536064 "Regulation of Insulin Secretion" xref: Reactome:400508 "Incretin Synthesis, Secretion, and Inactivation" xref: Reactome:422356 "Regulation of Insulin Secretion" is_a: GO:0090276 ! regulation of peptide hormone secretion relationship: regulates GO:0030073 ! insulin secretion [Term] id: GO:0050797 name: thymidylate synthase (FAD) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + FADH(2) = (6S)-5,6,7,8-tetrahydrofolate + FAD + H(+) + thymidylate." [EC:2.1.1.148, RHEA:12247] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.148] synonym: "FDTS activity" EXACT [EC:2.1.1.148] synonym: "flavin dependent thymidylate synthase activity" EXACT [EC:2.1.1.148] synonym: "Thy1 activity" EXACT [] synonym: "ThyX activity" EXACT [] xref: EC:2.1.1.148 xref: KEGG:R06613 xref: MetaCyc:RXN-8850 xref: RHEA:12247 is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0050798 name: activated T cell proliferation namespace: biological_process def: "The expansion of a T cell population following activation by an antigenic stimulus." [GOC:add, GOC:dph] comment: Note that this term refers to the proliferation of previously activated T cells; it is to be used for gene products involved in T cell proliferation following an antigenic stimulus, including both proteins internal to the T cell and external factors, such as IL-2, which specifically promote proliferation of activated T cells. synonym: "activated T lymphocyte proliferation" EXACT [] synonym: "activated T-cell proliferation" EXACT [] synonym: "activated T-lymphocyte proliferation" EXACT [] synonym: "proliferation of activated T cells" EXACT [GOC:mah] is_a: GO:0042098 ! T cell proliferation [Term] id: GO:0050799 name: cocaine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [GOC:ai] subset: gosubset_prok synonym: "cocaine anabolism" EXACT [] synonym: "cocaine biosynthesis" EXACT [] synonym: "cocaine formation" EXACT [] synonym: "cocaine synthesis" EXACT [] is_a: GO:0009710 ! tropane alkaloid biosynthetic process is_a: GO:0050783 ! cocaine metabolic process [Term] id: GO:0050800 name: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance." [EC:3.6.5.-, GOC:ai] comment: This term was made obsolete because it represents both process and function information. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0006810 [Term] id: GO:0050801 name: ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of ions within an organism or cell." [GOC:ai] subset: gosubset_prok synonym: "electrolyte homeostasis" RELATED [] synonym: "negative regulation of crystal biosynthesis" RELATED [] synonym: "negative regulation of crystal formation" RELATED [] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0050802 name: circadian sleep/wake cycle, sleep namespace: biological_process def: "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai] is_a: GO:0022410 ! circadian sleep/wake cycle process is_a: GO:0030431 ! sleep [Term] id: GO:0050803 name: regulation of synapse structure and activity namespace: biological_process def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0007268 ! synaptic transmission [Term] id: GO:0050804 name: regulation of synaptic transmission namespace: biological_process def: "Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] is_a: GO:0051969 ! regulation of transmission of nerve impulse relationship: regulates GO:0007268 ! synaptic transmission [Term] id: GO:0050805 name: negative regulation of synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "down regulation of synaptic transmission" EXACT [] synonym: "down-regulation of synaptic transmission" EXACT [] synonym: "downregulation of synaptic transmission" EXACT [] synonym: "inhibition of synaptic transmission" NARROW [] is_a: GO:0050804 ! regulation of synaptic transmission is_a: GO:0051970 ! negative regulation of transmission of nerve impulse relationship: negatively_regulates GO:0007268 ! synaptic transmission [Term] id: GO:0050806 name: positive regulation of synaptic transmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "activation of synaptic transmission" NARROW [] synonym: "stimulation of synaptic transmission" NARROW [] synonym: "up regulation of synaptic transmission" EXACT [] synonym: "up-regulation of synaptic transmission" EXACT [] synonym: "upregulation of synaptic transmission" EXACT [] is_a: GO:0050804 ! regulation of synaptic transmission is_a: GO:0051971 ! positive regulation of transmission of nerve impulse relationship: positively_regulates GO:0007268 ! synaptic transmission [Term] id: GO:0050807 name: regulation of synapse organization namespace: biological_process def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of synapse structure" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: part_of GO:0050803 ! regulation of synapse structure and activity relationship: regulates GO:0050808 ! synapse organization [Term] id: GO:0050808 name: synapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] synonym: "synapse development" EXACT [] synonym: "synapse morphogenesis" RELATED [GOC:BHF] synonym: "synapse organisation" EXACT [GOC:curators] synonym: "synapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0043062 ! extracellular structure organization [Term] id: GO:0050809 name: diazepam binding namespace: molecular_function def: "Interacting selectively and non-covalently with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "diazepam binding inhibitor activity" RELATED [] synonym: "Valium binding" EXACT [] is_a: GO:0008144 ! drug binding [Term] id: GO:0050810 name: regulation of steroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai] subset: gosubset_prok synonym: "regulation of steroid anabolism" EXACT [] synonym: "regulation of steroid biosynthesis" EXACT [] synonym: "regulation of steroid formation" EXACT [] synonym: "regulation of steroid synthesis" EXACT [] synonym: "regulation of steroidogenesis" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0006694 ! steroid biosynthetic process [Term] id: GO:0050811 name: GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai] synonym: "4-aminobutanoate receptor binding" EXACT [] synonym: "4-aminobutyrate receptor binding" EXACT [] synonym: "diazepam binding inhibitor activity" RELATED [] synonym: "gamma-aminobutyric acid receptor binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0050812 name: regulation of acyl-CoA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA." [GOC:ai] subset: gosubset_prok synonym: "regulation of acyl-CoA anabolism" EXACT [] synonym: "regulation of acyl-CoA biosynthesis" EXACT [] synonym: "regulation of acyl-CoA formation" EXACT [] synonym: "regulation of acyl-CoA synthesis" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process relationship: regulates GO:0071616 ! acyl-CoA biosynthetic process [Term] id: GO:0050813 name: epothilone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [http://www.onelook.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "epothilone metabolism" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process [Term] id: GO:0050814 name: epothilone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [GOC:ai] subset: gosubset_prok synonym: "epothilone anabolism" EXACT [] synonym: "epothilone biosynthesis" EXACT [] synonym: "epothilone formation" EXACT [] synonym: "epothilone synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0050813 ! epothilone metabolic process [Term] id: GO:0050815 name: phosphoserine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated serine residue within a protein." [GOC:ai] synonym: "phosphoserine/phosphothreonine binding" BROAD [] is_a: GO:0016597 ! amino acid binding is_a: GO:0045309 ! protein phosphorylated amino acid binding [Term] id: GO:0050816 name: phosphothreonine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated threonine residue within a protein." [GOC:ai] synonym: "phosphoserine/phosphothreonine binding" BROAD [] is_a: GO:0045309 ! protein phosphorylated amino acid binding [Term] id: GO:0050817 name: coagulation namespace: biological_process def: "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir synonym: "clotting" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0050818 name: regulation of coagulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai] synonym: "regulation of clotting" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0050817 ! coagulation [Term] id: GO:0050819 name: negative regulation of coagulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." [GOC:ai] synonym: "anticoagulant activity" RELATED [] synonym: "down regulation of coagulation" EXACT [] synonym: "down-regulation of coagulation" EXACT [] synonym: "downregulation of coagulation" EXACT [] synonym: "inhibition of coagulation" NARROW [] synonym: "negative regulation of clotting." EXACT [] is_a: GO:0050818 ! regulation of coagulation is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0050817 ! coagulation [Term] id: GO:0050820 name: positive regulation of coagulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of coagulation." [GOC:ai] synonym: "activation of coagulation" NARROW [] synonym: "positive regulation of clotting" EXACT [] synonym: "stimulation of coagulation" NARROW [] synonym: "up regulation of coagulation" EXACT [] synonym: "up-regulation of coagulation" EXACT [] synonym: "upregulation of coagulation" EXACT [] is_a: GO:0050818 ! regulation of coagulation is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0050817 ! coagulation [Term] id: GO:0050821 name: protein stabilization namespace: biological_process def: "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] subset: gosubset_prok synonym: "lysosomal protein stabilization" NARROW [] synonym: "positive regulation of protein stability" EXACT [] synonym: "protein sequestering" RELATED [] synonym: "protein stabilization activity" RELATED [] is_a: GO:0031647 ! regulation of protein stability [Term] id: GO:0050822 name: peptide stabilization namespace: biological_process def: "Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded." [GOC:ai] subset: gosubset_prok synonym: "peptide stabilization activity" RELATED [] is_a: GO:0006518 ! peptide metabolic process [Term] id: GO:0050823 name: peptide antigen stabilization namespace: biological_process def: "Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded." [GOC:ai] subset: gosubset_prok synonym: "peptide antigen stabilization activity" RELATED [] is_a: GO:0050822 ! peptide stabilization relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0050824 name: water binding namespace: molecular_function def: "Interacting selectively and non-covalently with water (H2O)." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0050825 name: ice binding namespace: molecular_function def: "Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [GOC:curators] subset: gosubset_prok synonym: "antifreeze activity" RELATED [] synonym: "ice crystal binding" EXACT [] synonym: "ice nucleation activity" RELATED [] synonym: "ice nucleation inhibitor activity" RELATED [] is_a: GO:0050824 ! water binding [Term] id: GO:0050826 name: response to freezing namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl] subset: gosubset_prok synonym: "antifreeze activity" RELATED [] synonym: "ice nucleation inhibitor activity" RELATED [] is_a: GO:0009409 ! response to cold [Term] id: GO:0050827 name: toxin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a toxin receptor, a receptor for substances that cause injury to living organisms." [GOC:ai] synonym: "channel-forming toxin activity" RELATED [] synonym: "cytotoxin activity" RELATED [] synonym: "endotoxin activity" RELATED [] synonym: "enterotoxin activity" RELATED [] synonym: "exotoxin activity" RELATED [] synonym: "lipoprotein toxin" RELATED [] synonym: "neurotoxin activity" RELATED [] synonym: "pore-forming toxin activity" RELATED [] synonym: "toxin activity" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0050828 name: regulation of liquid surface tension namespace: biological_process def: "Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "regulation of surface tension of a liquid" EXACT [] synonym: "surfactant activity" RELATED [] is_a: GO:0042592 ! homeostatic process [Term] id: GO:0050829 name: defense response to Gram-negative bacterium namespace: biological_process def: "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] synonym: "defence response to Gram-negative bacteria" EXACT [] synonym: "defence response to Gram-negative bacterium" EXACT [] synonym: "defense response to Gram-negative bacteria" EXACT [] synonym: "Gram-negative antibacterial peptide activity" RELATED [] is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0050830 name: defense response to Gram-positive bacterium namespace: biological_process def: "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] subset: gosubset_prok synonym: "defence response to Gram-positive bacteria" EXACT [] synonym: "defence response to Gram-positive bacterium" EXACT [] synonym: "defense response to Gram-positive bacteria" EXACT [] synonym: "Gram-positive antibacterial peptide activity" RELATED [] is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0050831 name: male-specific defense response to bacterium namespace: biological_process def: "A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:ai] synonym: "male-specific antibacterial peptide activity" RELATED [] synonym: "male-specific defence response to bacteria" EXACT [] synonym: "male-specific defence response to bacterium" EXACT [] synonym: "male-specific defense response to bacteria" EXACT [] is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0050832 name: defense response to fungus namespace: biological_process alt_id: GO:0042831 def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] synonym: "defence response to fungi" EXACT [] synonym: "defence response to fungus" EXACT [] synonym: "defense response to fungi" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0009620 ! response to fungus [Term] id: GO:0050833 name: pyruvate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] xref: Reactome:162197 "pyruvate transmembrane transporter activity" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0050834 name: molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide namespace: biological_process def: "The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355] subset: gosubset_prok xref: RESID:AA0355 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0050835 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [RESID:AA0356] subset: gosubset_prok xref: RESID:AA0356 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster is_a: GO:0050843 ! S-adenosylmethionine catabolic process [Term] id: GO:0050836 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide." [RESID:AA0357] subset: gosubset_prok xref: RESID:AA0357 is_a: GO:0018195 ! peptidyl-arginine modification is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0050837 name: peptide cross-linking via L-cysteinyl-L-selenocysteine namespace: biological_process def: "The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P." [RESID:AA0358] subset: gosubset_prok xref: RESID:AA0358 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0050844 ! peptidyl-selenocysteine modification [Term] id: GO:0050838 name: peptidyl-5-hydroxy-L-lysine trimethylation namespace: biological_process def: "The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359] subset: gosubset_prok xref: RESID:AA0359 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0050839 name: cell adhesion molecule binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai] synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "CAM binding" EXACT [] synonym: "cell adhesion molecule activity" RELATED [] synonym: "cell adhesion receptor activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0050840 name: extracellular matrix binding namespace: molecular_function def: "Interacting selectively and non-covalently with a component of the extracellular matrix." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "extracellular matrix constituent binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0050841 name: peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine namespace: biological_process def: "The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359] subset: gosubset_prok synonym: "peptidyl trimethyl lysine hydroxylase activity" EXACT [] synonym: "peptidyl-trimethyl-lysine hydroxylase activity" EXACT [] xref: RESID:AA0359 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0050842 name: copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide namespace: biological_process def: "The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355] subset: gosubset_prok xref: RESID:AA0355 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster [Term] id: GO:0050843 name: S-adenosylmethionine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] subset: gosubset_prok synonym: "S-adenosyl methionine catabolic process" EXACT [] synonym: "S-adenosyl methionine catabolism" EXACT [] synonym: "S-adenosylmethionine breakdown" EXACT [] synonym: "S-adenosylmethionine catabolism" EXACT [] synonym: "S-adenosylmethionine degradation" EXACT [] synonym: "SAM catabolic process" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process is_a: GO:0046500 ! S-adenosylmethionine metabolic process [Term] id: GO:0050844 name: peptidyl-selenocysteine modification namespace: biological_process def: "The modification of peptidyl-selenocysteine." [GOC:ai] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0050845 name: teichuronic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893] subset: gosubset_prok synonym: "teichuronic acid anabolism" EXACT [] synonym: "teichuronic acid biosynthesis" EXACT [] synonym: "teichuronic acid formation" EXACT [] synonym: "teichuronic acid synthesis" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process is_a: GO:0050846 ! teichuronic acid metabolic process relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0050846 name: teichuronic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893] subset: gosubset_prok synonym: "teichuronic acid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process [Term] id: GO:0050847 name: progesterone receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a progesterone binding to its receptor." [GOC:ai, GOC:mah, PMID:14744870] synonym: "progesterone receptor signalling pathway" EXACT [] is_a: GO:0030518 ! steroid hormone receptor signaling pathway [Term] id: GO:0050848 name: regulation of calcium-mediated signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai] synonym: "regulation of calcium-mediated signalling" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0019722 ! calcium-mediated signaling [Term] id: GO:0050849 name: negative regulation of calcium-mediated signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling." [GOC:ai, PMID:11696592] synonym: "down regulation of calcium-mediated signaling" EXACT [] synonym: "down-regulation of calcium-mediated signaling" EXACT [] synonym: "downregulation of calcium-mediated signaling" EXACT [] synonym: "inhibition of calcium-mediated signaling" NARROW [] synonym: "negative regulation of calcium-mediated signalling" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0050848 ! regulation of calcium-mediated signaling relationship: negatively_regulates GO:0019722 ! calcium-mediated signaling [Term] id: GO:0050850 name: positive regulation of calcium-mediated signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai] synonym: "activation of calcium-mediated signaling" NARROW [] synonym: "positive regulation of calcium-mediated signalling" EXACT [] synonym: "stimulation of calcium-mediated signaling" NARROW [] synonym: "up regulation of calcium-mediated signaling" EXACT [] synonym: "up-regulation of calcium-mediated signaling" EXACT [] synonym: "upregulation of calcium-mediated signaling" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0050848 ! regulation of calcium-mediated signaling relationship: positively_regulates GO:0019722 ! calcium-mediated signaling [Term] id: GO:0050851 name: antigen receptor-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." [GOC:add] synonym: "antigen receptor-mediated signalling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0050852 name: T cell receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GOC:add] synonym: "T lymphocyte receptor signaling pathway" EXACT [] synonym: "T lymphocyte receptor signalling pathway" EXACT [] synonym: "T-cell receptor signaling pathway" EXACT [] synonym: "T-cell receptor signalling pathway" EXACT [] synonym: "T-lymphocyte receptor signaling pathway" EXACT [] synonym: "T-lymphocyte receptor signalling pathway" EXACT [] synonym: "TCR signaling pathway" EXACT [] xref: Reactome:1253544 "TCR signaling" xref: Reactome:1280483 "TCR signaling" xref: Reactome:1299307 "TCR signaling" xref: Reactome:1327061 "TCR signaling" xref: Reactome:1353155 "TCR signaling" xref: Reactome:1373333 "TCR signaling" xref: Reactome:1393357 "TCR signaling" xref: Reactome:1417851 "TCR signaling" xref: Reactome:1450940 "TCR signaling" xref: Reactome:1471328 "TCR signaling" xref: Reactome:1483294 "TCR signaling" xref: Reactome:1496980 "TCR signaling" xref: Reactome:1514367 "TCR signaling" xref: Reactome:1521243 "TCR signaling" xref: Reactome:1526953 "TCR signaling" xref: Reactome:1532688 "TCR signaling" xref: Reactome:202403 "TCR signaling" is_a: GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050853 name: B cell receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add] synonym: "B cell receptor signalling pathway" EXACT [] synonym: "B lymphocyte receptor signaling pathway" EXACT [] synonym: "B lymphocyte receptor signalling pathway" EXACT [] synonym: "B-cell receptor signaling pathway" EXACT [] synonym: "B-cell receptor signalling pathway" EXACT [] synonym: "B-lymphocyte receptor signaling pathway" EXACT [] synonym: "B-lymphocyte receptor signalling pathway" EXACT [] is_a: GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050854 name: regulation of antigen receptor-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] synonym: "regulation of antigen receptor mediated signalling pathway" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050855 name: regulation of B cell receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] synonym: "regulation of B cell receptor signalling pathway" EXACT [] synonym: "regulation of B lymphocyte receptor signaling pathway" EXACT [] synonym: "regulation of B lymphocyte receptor signalling pathway" EXACT [] synonym: "regulation of B-cell receptor signaling pathway" EXACT [] synonym: "regulation of B-cell receptor signalling pathway" EXACT [] synonym: "regulation of B-lymphocyte receptor signaling pathway" EXACT [] synonym: "regulation of B-lymphocyte receptor signalling pathway" EXACT [] is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway relationship: regulates GO:0050853 ! B cell receptor signaling pathway [Term] id: GO:0050856 name: regulation of T cell receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] synonym: "regulation of T lymphocyte receptor signaling pathway" EXACT [] synonym: "regulation of T lymphocyte receptor signalling pathway" EXACT [] synonym: "regulation of T-cell receptor signaling pathway" EXACT [] synonym: "regulation of T-cell receptor signalling pathway" EXACT [] synonym: "regulation of T-lymphocyte receptor signaling pathway" EXACT [] synonym: "regulation of T-lymphocyte receptor signalling pathway" EXACT [] synonym: "regulation of TCR signaling pathway" EXACT [] is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway relationship: regulates GO:0050852 ! T cell receptor signaling pathway [Term] id: GO:0050857 name: positive regulation of antigen receptor-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] synonym: "activation of antigen receptor-mediated signaling pathway" NARROW [] synonym: "positive regulation of antigen receptor mediated signalling pathway" EXACT [] synonym: "stimulation of antigen receptor-mediated signaling pathway" NARROW [] synonym: "up regulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "up-regulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "upregulation of antigen receptor-mediated signaling pathway" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway relationship: positively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050858 name: negative regulation of antigen receptor-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] synonym: "down regulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "down-regulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "downregulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "inhibition of antigen receptor-mediated signaling pathway" NARROW [] synonym: "negative regulation of antigen receptor mediated signalling pathway" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway relationship: negatively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050859 name: negative regulation of B cell receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] synonym: "down regulation of B cell receptor signaling pathway" EXACT [] synonym: "down-regulation of B cell receptor signaling pathway" EXACT [] synonym: "downregulation of B cell receptor signaling pathway" EXACT [] synonym: "inhibition of B cell receptor signaling pathway" NARROW [] synonym: "negative regulation of B cell receptor signalling pathway" EXACT [] synonym: "negative regulation of B lymphocyte receptor signaling pathway" EXACT [] synonym: "negative regulation of B lymphocyte receptor signalling pathway" EXACT [] synonym: "negative regulation of B-cell receptor signaling pathway" EXACT [] synonym: "negative regulation of B-cell receptor signalling pathway" EXACT [] synonym: "negative regulation of B-lymphocyte receptor signaling pathway" EXACT [] synonym: "negative regulation of B-lymphocyte receptor signalling pathway" EXACT [] is_a: GO:0050855 ! regulation of B cell receptor signaling pathway is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway relationship: negatively_regulates GO:0050853 ! B cell receptor signaling pathway [Term] id: GO:0050860 name: negative regulation of T cell receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] synonym: "down regulation of T cell receptor signaling pathway" EXACT [] synonym: "down-regulation of T cell receptor signaling pathway" EXACT [] synonym: "downregulation of T cell receptor signaling pathway" EXACT [] synonym: "inhibition of T cell receptor signaling pathway" NARROW [] synonym: "negative regulation of T cell receptor signalling pathway" EXACT [] synonym: "negative regulation of T lymphocyte receptor signaling pathway" EXACT [] synonym: "negative regulation of T lymphocyte receptor signalling pathway" EXACT [] synonym: "negative regulation of T-cell receptor signaling pathway" EXACT [] synonym: "negative regulation of T-lymphocyte receptor signaling pathway" EXACT [] synonym: "negative regulation of T-lymphocyte receptor signalling pathway" EXACT [] synonym: "negative regulation of TCR signaling pathway" EXACT [] is_a: GO:0050856 ! regulation of T cell receptor signaling pathway is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway relationship: negatively_regulates GO:0050852 ! T cell receptor signaling pathway [Term] id: GO:0050861 name: positive regulation of B cell receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] synonym: "activation of B cell receptor signaling pathway" NARROW [] synonym: "positive regulation of B cell receptor signalling pathway" EXACT [] synonym: "positive regulation of B lymphocyte receptor signaling pathway" EXACT [] synonym: "positive regulation of B lymphocyte receptor signalling pathway" EXACT [] synonym: "positive regulation of B-cell receptor signaling pathway" EXACT [] synonym: "positive regulation of B-cell receptor signalling pathway" EXACT [] synonym: "positive regulation of B-lymphocyte receptor signaling pathway" EXACT [] synonym: "positive regulation of B-lymphocyte receptor signalling pathway" EXACT [] synonym: "stimulation of B cell receptor signaling pathway" NARROW [] synonym: "up regulation of B cell receptor signaling pathway" EXACT [] synonym: "up-regulation of B cell receptor signaling pathway" EXACT [] synonym: "upregulation of B cell receptor signaling pathway" EXACT [] is_a: GO:0050855 ! regulation of B cell receptor signaling pathway is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway relationship: positively_regulates GO:0050853 ! B cell receptor signaling pathway [Term] id: GO:0050862 name: positive regulation of T cell receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] synonym: "activation of T cell receptor signaling pathway" NARROW [] synonym: "positive regulation of T cell receptor signalling pathway" EXACT [] synonym: "positive regulation of T lymphocyte receptor signaling pathway" EXACT [] synonym: "positive regulation of T lymphocyte receptor signalling pathway" EXACT [] synonym: "positive regulation of T-cell receptor signaling pathway" EXACT [] synonym: "positive regulation of T-lymphocyte receptor signaling pathway" EXACT [] synonym: "positive regulation of T-lymphocyte receptor signalling pathway" EXACT [] synonym: "positive regulation of TCR signaling pathway" EXACT [] synonym: "stimulation of T cell receptor signaling pathway" NARROW [] synonym: "up regulation of T cell receptor signaling pathway" EXACT [] synonym: "up-regulation of T cell receptor signaling pathway" EXACT [] synonym: "upregulation of T cell receptor signaling pathway" EXACT [] is_a: GO:0050856 ! regulation of T cell receptor signaling pathway is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway relationship: positively_regulates GO:0050852 ! T cell receptor signaling pathway [Term] id: GO:0050863 name: regulation of T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "regulation of T lymphocyte activation" EXACT [] synonym: "regulation of T-cell activation" EXACT [] synonym: "regulation of T-lymphocyte activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation relationship: regulates GO:0042110 ! T cell activation [Term] id: GO:0050864 name: regulation of B cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell activation." [GOC:ai] synonym: "regulation of B lymphocyte activation" EXACT [] synonym: "regulation of B-cell activation" EXACT [] synonym: "regulation of B-lymphocyte activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation relationship: regulates GO:0042113 ! B cell activation [Term] id: GO:0050865 name: regulation of cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0001775 ! cell activation [Term] id: GO:0050866 name: negative regulation of cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai] synonym: "down regulation of cell activation" EXACT [] synonym: "down-regulation of cell activation" EXACT [] synonym: "downregulation of cell activation" EXACT [] synonym: "inhibition of cell activation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050865 ! regulation of cell activation relationship: negatively_regulates GO:0001775 ! cell activation [Term] id: GO:0050867 name: positive regulation of cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai] synonym: "activation of cell activation" NARROW [] synonym: "stimulation of cell activation" NARROW [] synonym: "up regulation of cell activation" EXACT [] synonym: "up-regulation of cell activation" EXACT [] synonym: "upregulation of cell activation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050865 ! regulation of cell activation relationship: positively_regulates GO:0001775 ! cell activation [Term] id: GO:0050868 name: negative regulation of T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "down regulation of T cell activation" EXACT [] synonym: "down-regulation of T cell activation" EXACT [] synonym: "downregulation of T cell activation" EXACT [] synonym: "inhibition of T cell activation" NARROW [] synonym: "negative regulation of T lymphocyte activation" EXACT [] synonym: "negative regulation of T-cell activation" EXACT [] synonym: "negative regulation of T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation relationship: negatively_regulates GO:0042110 ! T cell activation [Term] id: GO:0050869 name: negative regulation of B cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation." [GOC:ai] synonym: "down regulation of B cell activation" EXACT [] synonym: "down-regulation of B cell activation" EXACT [] synonym: "downregulation of B cell activation" EXACT [] synonym: "inhibition of B cell activation" NARROW [] synonym: "negative regulation of B lymphocyte activation" EXACT [] synonym: "negative regulation of B-cell activation" EXACT [] synonym: "negative regulation of B-lymphocyte activation" EXACT [] is_a: GO:0050864 ! regulation of B cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation relationship: negatively_regulates GO:0042113 ! B cell activation [Term] id: GO:0050870 name: positive regulation of T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "activation of T cell activation" NARROW [] synonym: "positive regulation of T lymphocyte activation" EXACT [] synonym: "positive regulation of T-cell activation" EXACT [] synonym: "positive regulation of T-lymphocyte activation" EXACT [] synonym: "stimulation of T cell activation" NARROW [] synonym: "up regulation of T cell activation" EXACT [] synonym: "up-regulation of T cell activation" EXACT [] synonym: "upregulation of T cell activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation relationship: positively_regulates GO:0042110 ! T cell activation [Term] id: GO:0050871 name: positive regulation of B cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B cell activation." [GOC:ai] synonym: "activation of B cell activation" NARROW [] synonym: "positive regulation of B lymphocyte activation" EXACT [] synonym: "positive regulation of B-cell activation" EXACT [] synonym: "positive regulation of B-lymphocyte activation" EXACT [] synonym: "stimulation of B cell activation" NARROW [] synonym: "up regulation of B cell activation" EXACT [] synonym: "up-regulation of B cell activation" EXACT [] synonym: "upregulation of B cell activation" EXACT [] is_a: GO:0050864 ! regulation of B cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation relationship: positively_regulates GO:0042113 ! B cell activation [Term] id: GO:0050872 name: white fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [PMID:12508945] synonym: "white adipocyte cell differentiation" EXACT [] synonym: "white adipocyte differentiation" EXACT [] is_a: GO:0045444 ! fat cell differentiation [Term] id: GO:0050873 name: brown fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [PMID:12588810] synonym: "brown adipocyte cell differentiation" EXACT [] synonym: "brown adipocyte differentiation" EXACT [] is_a: GO:0045444 ! fat cell differentiation [Term] id: GO:0050877 name: neurological system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio] subset: goslim_generic subset: goslim_pir synonym: "neurophysiological process" EXACT [] synonym: "pan-neural process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0050878 name: regulation of body fluid levels namespace: biological_process def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0050879 name: multicellular organismal movement namespace: biological_process def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb] subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0050880 name: regulation of blood vessel size namespace: biological_process def: "Any process that modulates the size of blood vessels." [GOC:ai] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0035150 ! regulation of tube size relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0050881 name: musculoskeletal movement namespace: biological_process def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph] is_a: GO:0050879 ! multicellular organismal movement [Term] id: GO:0050882 name: voluntary musculoskeletal movement namespace: biological_process def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." [GOC:dph] is_a: GO:0050881 ! musculoskeletal movement [Term] id: GO:0050883 name: musculoskeletal movement, spinal reflex action namespace: biological_process def: "Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord." [GOC:dph] is_a: GO:0050881 ! musculoskeletal movement is_a: GO:0060004 ! reflex [Term] id: GO:0050884 name: neuromuscular process controlling posture namespace: biological_process def: "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts." [GOC:dph, GOC:tb] synonym: "regulation of posture" EXACT [] is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0050885 name: neuromuscular process controlling balance namespace: biological_process def: "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph, http://www.onelook.com/] synonym: "regulation of balance" RELATED [] is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0050886 name: endocrine process namespace: biological_process def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: goslim_pir synonym: "endocrine physiological process" EXACT [] synonym: "endocrine physiology" EXACT [] is_a: GO:0003008 ! system process [Term] id: GO:0050887 name: determination of sensory modality namespace: biological_process def: "The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain." [ISBN:0721619908] is_a: GO:0050893 ! sensory processing [Term] id: GO:0050888 name: determination of stimulus location namespace: biological_process def: "The determination of where on the body surface, within the body or in the environment a stimulus originates." [ISBN:0721619908] is_a: GO:0050893 ! sensory processing [Term] id: GO:0050889 name: determination of stimulus intensity namespace: biological_process def: "The determination of the perceived strength of a sensory stimulus." [ISBN:0721619908] is_a: GO:0050893 ! sensory processing [Term] id: GO:0050890 name: cognition namespace: biological_process def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [http://www.onelook.com/, ISBN:0721619908] xref: Wikipedia:Cognition is_a: GO:0050877 ! neurological system process [Term] id: GO:0050891 name: multicellular organismal water homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism." [GOC:dph, GOC:tb] synonym: "body fluid osmoregulation" RELATED [GOC:dph, GOC:tb] is_a: GO:0030104 ! water homeostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0050892 name: intestinal absorption namespace: biological_process def: "Any process in which nutrients are taken up from the contents of the intestine." [GOC:ai, GOC:dph] is_a: GO:0022600 ! digestive system process [Term] id: GO:0050893 name: sensory processing namespace: biological_process def: "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0050890 ! cognition relationship: part_of GO:0007600 ! sensory perception [Term] id: GO:0050894 name: determination of affect namespace: biological_process def: "Any process in which an emotional response is associated with a particular sensory stimulation." [GOC:ai, GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0050893 ! sensory processing [Term] id: GO:0050896 name: response to stimulus namespace: biological_process alt_id: GO:0051869 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: goslim_pir subset: gosubset_prok subset: high_level_annotation_qc synonym: "physiological response to stimulus" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0050897 name: cobalt ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cobalt (Co) ion." [GOC:ai] subset: gosubset_prok synonym: "cobalt binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0050898 name: nitrile metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile." [CHEBI:18379, GOC:curators, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "nitrile metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0050899 name: nitrile catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "nitrile breakdown" EXACT [] synonym: "nitrile catabolism" EXACT [] synonym: "nitrile degradation" EXACT [] is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0050900 name: leukocyte migration namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration" EXACT [] synonym: "immune cell trafficking" EXACT [] synonym: "leucocyte migration" EXACT [] synonym: "leucocyte trafficking" EXACT [] synonym: "leukocyte trafficking" EXACT [] xref: Reactome:1253237 "Cell surface interactions at the vascular wall" xref: Reactome:1280195 "Cell surface interactions at the vascular wall" xref: Reactome:1299046 "Cell surface interactions at the vascular wall" xref: Reactome:1326750 "Cell surface interactions at the vascular wall" xref: Reactome:1352854 "Cell surface interactions at the vascular wall" xref: Reactome:1373318 "Cell surface interactions at the vascular wall" xref: Reactome:1393359 "Cell surface interactions at the vascular wall" xref: Reactome:1417853 "Cell surface interactions at the vascular wall" xref: Reactome:1450672 "Cell surface interactions at the vascular wall" xref: Reactome:1471336 "Cell surface interactions at the vascular wall" xref: Reactome:202733 "Cell surface interactions at the vascular wall" is_a: GO:0002376 ! immune system process is_a: GO:0016477 ! cell migration [Term] id: GO:0050901 name: leukocyte tethering or rolling namespace: biological_process def: "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation." [ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] is_a: GO:0007159 ! leukocyte cell-cell adhesion relationship: part_of GO:0045123 ! cellular extravasation [Term] id: GO:0050902 name: leukocyte adhesive activation namespace: biological_process def: "The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation." [ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "leukocyte adhesive triggering" EXACT [] is_a: GO:0045321 ! leukocyte activation relationship: part_of GO:0045123 ! cellular extravasation [Term] id: GO:0050903 name: leukocyte activation-dependent arrest namespace: biological_process def: "The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation." [ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] is_a: GO:0007159 ! leukocyte cell-cell adhesion relationship: part_of GO:0045123 ! cellular extravasation [Term] id: GO:0050904 name: diapedesis namespace: biological_process def: "The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [ISBN:078173514, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] comment: Note that the term diapedesis, although sometimes used as a direct synonym for cellular extravasation, is used here for the specific final step of the process, in concordance with recent reviews of the topic. is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0045123 ! cellular extravasation [Term] id: GO:0050905 name: neuromuscular process namespace: biological_process def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai] synonym: "neuromotor process" EXACT [] synonym: "neuromuscular physiological process" EXACT [] is_a: GO:0050877 ! neurological system process [Term] id: GO:0050906 name: detection of stimulus involved in sensory perception namespace: biological_process def: "The series of events involved in sensory perception in which a sensory stimulus is received by a cell and converted into a molecular signal." [GOC:ai, GOC:dph] synonym: "sensory detection of stimulus" EXACT [] synonym: "sensory perception, sensory transduction of stimulus" EXACT [] synonym: "sensory perception, stimulus detection" EXACT [] synonym: "sensory transduction" EXACT [] xref: Wikipedia:Transduction_(physiology) is_a: GO:0051606 ! detection of stimulus relationship: part_of GO:0007600 ! sensory perception [Term] id: GO:0050907 name: detection of chemical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a sensory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "sensory detection of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of chemical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception relationship: part_of GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050908 name: detection of light stimulus involved in visual perception namespace: biological_process def: "The series of events involved in visual perception in which a sensory light stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "sensory detection of light during visual perception" EXACT [] synonym: "sensory detection of light stimulus during visual perception" EXACT [] synonym: "sensory transduction of light during visual perception" EXACT [] synonym: "sensory transduction of light stimulus during visual perception" EXACT [] synonym: "visual perception, detection of light stimulus" EXACT [] synonym: "visual perception, sensory transduction during perception of light" EXACT [] synonym: "visual perception, sensory transduction of light stimulus" EXACT [] is_a: GO:0009584 ! detection of visible light is_a: GO:0050962 ! detection of light stimulus involved in sensory perception relationship: part_of GO:0007601 ! visual perception [Term] id: GO:0050909 name: sensory perception of taste namespace: biological_process def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] synonym: "gustation" EXACT [] synonym: "sense of taste" EXACT [] synonym: "taste" EXACT [] synonym: "taste perception" EXACT [] xref: Wikipedia:Taste is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050910 name: detection of mechanical stimulus involved in sensory perception of sound namespace: biological_process alt_id: GO:0009592 alt_id: GO:0055128 def: "The series of events involved in the perception of sound vibration. The vibration is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "detection of sound" EXACT [] synonym: "hearing, sensory transduction of sound" EXACT [] synonym: "perception of sound, detection of mechanical stimulus" EXACT [] synonym: "perception of sound, sensory detection of mechanical stimulus" EXACT [] synonym: "perception of sound, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during perception of sound" EXACT [] synonym: "sensory transduction of mechanical stimulus during perception of sound" EXACT [] synonym: "sensory transduction of sound" EXACT [] is_a: GO:0050877 ! neurological system process is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: part_of GO:0007605 ! sensory perception of sound [Term] id: GO:0050911 name: detection of chemical stimulus involved in sensory perception of smell namespace: biological_process def: "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "perception of smell, detection of chemical stimulus" EXACT [] synonym: "perception of smell, sensory detection of chemical stimulus" EXACT [] synonym: "perception of smell, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of smell" EXACT [] synonym: "sensory detection of scent" EXACT [] synonym: "sensory detection of smell" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of smell" EXACT [] synonym: "sensory transduction of scent" EXACT [] synonym: "sensory transduction of smell" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception relationship: part_of GO:0007608 ! sensory perception of smell [Term] id: GO:0050912 name: detection of chemical stimulus involved in sensory perception of taste namespace: biological_process def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "perception of taste, detection of chemical stimulus" EXACT [] synonym: "perception of taste, sensory detection of chemical stimulus" EXACT [] synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of taste" EXACT [] synonym: "sensory detection of taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT [] synonym: "sensory transduction of taste" EXACT [] synonym: "taste perception" BROAD [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception relationship: part_of GO:0050909 ! sensory perception of taste [Term] id: GO:0050913 name: sensory perception of bitter taste namespace: biological_process def: "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "bitter taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050914 name: sensory perception of salty taste namespace: biological_process def: "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "salty taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050915 name: sensory perception of sour taste namespace: biological_process def: "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "sour taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050916 name: sensory perception of sweet taste namespace: biological_process def: "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "sweet taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050917 name: sensory perception of umami taste namespace: biological_process def: "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process." [GOC:ai] synonym: "umami taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050918 name: positive chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] subset: gosubset_prok synonym: "chemoattraction" EXACT [] is_a: GO:0006935 ! chemotaxis [Term] id: GO:0050919 name: negative chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] synonym: "chemoaversion" EXACT [] synonym: "chemorepulsion" EXACT [] is_a: GO:0006935 ! chemotaxis [Term] id: GO:0050920 name: regulation of chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] subset: gosubset_prok is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050795 ! regulation of behavior relationship: regulates GO:0006935 ! chemotaxis [Term] id: GO:0050921 name: positive regulation of chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] subset: gosubset_prok synonym: "activation of chemotaxis" NARROW [] synonym: "stimulation of chemotaxis" NARROW [] synonym: "up regulation of chemotaxis" EXACT [] synonym: "up-regulation of chemotaxis" EXACT [] synonym: "upregulation of chemotaxis" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0050920 ! regulation of chemotaxis relationship: positively_regulates GO:0006935 ! chemotaxis [Term] id: GO:0050922 name: negative regulation of chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] synonym: "down regulation of chemotaxis" EXACT [] synonym: "down-regulation of chemotaxis" EXACT [] synonym: "downregulation of chemotaxis" EXACT [] synonym: "inhibition of chemotaxis" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0050920 ! regulation of chemotaxis relationship: negatively_regulates GO:0006935 ! chemotaxis [Term] id: GO:0050923 name: regulation of negative chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] is_a: GO:0050920 ! regulation of chemotaxis relationship: regulates GO:0050919 ! negative chemotaxis [Term] id: GO:0050924 name: positive regulation of negative chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] synonym: "activation of negative chemotaxis" NARROW [] synonym: "stimulation of negative chemotaxis" NARROW [] synonym: "up regulation of negative chemotaxis" EXACT [] synonym: "up-regulation of negative chemotaxis" EXACT [] synonym: "upregulation of negative chemotaxis" EXACT [] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:0050923 ! regulation of negative chemotaxis relationship: positively_regulates GO:0050919 ! negative chemotaxis [Term] id: GO:0050925 name: negative regulation of negative chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] synonym: "down regulation of negative chemotaxis" EXACT [] synonym: "down-regulation of negative chemotaxis" EXACT [] synonym: "downregulation of negative chemotaxis" EXACT [] synonym: "inhibition of negative chemotaxis" NARROW [] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0050923 ! regulation of negative chemotaxis relationship: negatively_regulates GO:0050919 ! negative chemotaxis [Term] id: GO:0050926 name: regulation of positive chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] subset: gosubset_prok is_a: GO:0050920 ! regulation of chemotaxis relationship: regulates GO:0050918 ! positive chemotaxis [Term] id: GO:0050927 name: positive regulation of positive chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] subset: gosubset_prok synonym: "activation of positive chemotaxis" NARROW [] synonym: "stimulation of positive chemotaxis" NARROW [] synonym: "up regulation of positive chemotaxis" EXACT [] synonym: "up-regulation of positive chemotaxis" EXACT [] synonym: "upregulation of positive chemotaxis" EXACT [] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:0050926 ! regulation of positive chemotaxis relationship: positively_regulates GO:0050918 ! positive chemotaxis [Term] id: GO:0050928 name: negative regulation of positive chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] synonym: "down regulation of positive chemotaxis" EXACT [] synonym: "down-regulation of positive chemotaxis" EXACT [] synonym: "downregulation of positive chemotaxis" EXACT [] synonym: "inhibition of positive chemotaxis" NARROW [] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0050926 ! regulation of positive chemotaxis relationship: negatively_regulates GO:0050918 ! positive chemotaxis [Term] id: GO:0050929 name: induction of negative chemotaxis namespace: biological_process def: "Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] is_a: GO:0050924 ! positive regulation of negative chemotaxis [Term] id: GO:0050930 name: induction of positive chemotaxis namespace: biological_process def: "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] subset: gosubset_prok is_a: GO:0050927 ! positive regulation of positive chemotaxis [Term] id: GO:0050931 name: pigment cell differentiation namespace: biological_process alt_id: GO:0043357 alt_id: GO:0043358 def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh] comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. synonym: "chromatophore differentiation" EXACT [] synonym: "pigmented cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048066 ! developmental pigmentation [Term] id: GO:0050932 name: regulation of pigment cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048070 ! regulation of developmental pigmentation relationship: regulates GO:0050931 ! pigment cell differentiation [Term] id: GO:0050933 name: early stripe melanocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development)." [PMID:11858836] synonym: "early stripe melanocyte cell differentiation" EXACT [] synonym: "early stripe melanophore differentiation" EXACT [] is_a: GO:0030318 ! melanocyte differentiation [Term] id: GO:0050934 name: late stripe melanocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development)." [PMID:11858836] synonym: "late stripe melanocyte cell differentiation" EXACT [] synonym: "late stripe melanophore differentiation" EXACT [] is_a: GO:0030318 ! melanocyte differentiation [Term] id: GO:0050935 name: iridophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance." [GOC:jid, GOC:mh, PMID:11858836] synonym: "iridophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0050936 name: xanthophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance." [GOC:jid, GOC:mh, PMID:11858836] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. synonym: "xanthophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0050937 name: regulation of iridophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of iridophore differentiation." [GOC:ai] is_a: GO:0050932 ! regulation of pigment cell differentiation relationship: regulates GO:0050935 ! iridophore differentiation [Term] id: GO:0050938 name: regulation of xanthophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of xanthophore differentiation." [GOC:ai] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. is_a: GO:0050932 ! regulation of pigment cell differentiation relationship: regulates GO:0050936 ! xanthophore differentiation [Term] id: GO:0050939 name: regulation of early stripe melanocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] synonym: "regulation of early stripe melanophore differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation relationship: regulates GO:0050933 ! early stripe melanocyte differentiation [Term] id: GO:0050940 name: regulation of late stripe melanocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] synonym: "regulation of late stripe melanophore differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation relationship: regulates GO:0050934 ! late stripe melanocyte differentiation [Term] id: GO:0050941 name: negative regulation of pigment cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "down regulation of pigment cell differentiation" EXACT [] synonym: "down-regulation of pigment cell differentiation" EXACT [] synonym: "downregulation of pigment cell differentiation" EXACT [] synonym: "inhibition of pigment cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation relationship: negatively_regulates GO:0050931 ! pigment cell differentiation [Term] id: GO:0050942 name: positive regulation of pigment cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "activation of pigment cell differentiation" NARROW [] synonym: "stimulation of pigment cell differentiation" NARROW [] synonym: "up regulation of pigment cell differentiation" EXACT [] synonym: "up-regulation of pigment cell differentiation" EXACT [] synonym: "upregulation of pigment cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation relationship: positively_regulates GO:0050931 ! pigment cell differentiation [Term] id: GO:0050943 name: negative regulation of iridophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation." [GOC:ai] synonym: "down regulation of iridophore differentiation" EXACT [] synonym: "down-regulation of iridophore differentiation" EXACT [] synonym: "downregulation of iridophore differentiation" EXACT [] synonym: "inhibition of iridophore differentiation" NARROW [] is_a: GO:0050937 ! regulation of iridophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation relationship: negatively_regulates GO:0050935 ! iridophore differentiation [Term] id: GO:0050944 name: negative regulation of xanthophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of xanthophore differentiation." [GOC:ai] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. synonym: "down regulation of xanthophore differentiation" EXACT [] synonym: "down-regulation of xanthophore differentiation" EXACT [] synonym: "downregulation of xanthophore differentiation" EXACT [] synonym: "inhibition of xanthophore differentiation" NARROW [] is_a: GO:0050938 ! regulation of xanthophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation relationship: negatively_regulates GO:0050936 ! xanthophore differentiation [Term] id: GO:0050945 name: positive regulation of iridophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of iridophore differentiation." [GOC:ai] synonym: "activation of iridophore differentiation" NARROW [] synonym: "stimulation of iridophore differentiation" NARROW [] synonym: "up regulation of iridophore differentiation" EXACT [] synonym: "up-regulation of iridophore differentiation" EXACT [] synonym: "upregulation of iridophore differentiation" EXACT [] is_a: GO:0050937 ! regulation of iridophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation relationship: positively_regulates GO:0050935 ! iridophore differentiation [Term] id: GO:0050946 name: positive regulation of xanthophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation." [GOC:ai] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. synonym: "activation of xanthophore differentiation" NARROW [] synonym: "stimulation of xanthophore differentiation" NARROW [] synonym: "up regulation of xanthophore differentiation" EXACT [] synonym: "up-regulation of xanthophore differentiation" EXACT [] synonym: "upregulation of xanthophore differentiation" EXACT [] is_a: GO:0050938 ! regulation of xanthophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation relationship: positively_regulates GO:0050936 ! xanthophore differentiation [Term] id: GO:0050947 name: negative regulation of early stripe melanocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] synonym: "down regulation of early stripe melanocyte differentiation" EXACT [] synonym: "down-regulation of early stripe melanocyte differentiation" EXACT [] synonym: "downregulation of early stripe melanocyte differentiation" EXACT [] synonym: "inhibition of early stripe melanocyte differentiation" NARROW [] synonym: "negative regulation of early stripe melanophore differentiation" EXACT [] is_a: GO:0045635 ! negative regulation of melanocyte differentiation is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation relationship: negatively_regulates GO:0050933 ! early stripe melanocyte differentiation [Term] id: GO:0050948 name: positive regulation of early stripe melanocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] synonym: "activation of early stripe melanocyte differentiation" NARROW [] synonym: "positive regulation of early stripe melanophore differentiation" EXACT [] synonym: "stimulation of early stripe melanocyte differentiation" NARROW [] synonym: "up regulation of early stripe melanocyte differentiation" EXACT [] synonym: "up-regulation of early stripe melanocyte differentiation" EXACT [] synonym: "upregulation of early stripe melanocyte differentiation" EXACT [] is_a: GO:0045636 ! positive regulation of melanocyte differentiation is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation relationship: positively_regulates GO:0050933 ! early stripe melanocyte differentiation [Term] id: GO:0050949 name: negative regulation of late stripe melanocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] synonym: "down regulation of late stripe melanocyte differentiation" EXACT [] synonym: "down-regulation of late stripe melanocyte differentiation" EXACT [] synonym: "downregulation of late stripe melanocyte differentiation" EXACT [] synonym: "inhibition of late stripe melanocyte differentiation" NARROW [] synonym: "negative regulation of late stripe melanophore differentiation" EXACT [] is_a: GO:0045635 ! negative regulation of melanocyte differentiation is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation relationship: negatively_regulates GO:0050934 ! late stripe melanocyte differentiation [Term] id: GO:0050950 name: positive regulation of late stripe melanocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] synonym: "activation of late stripe melanocyte differentiation" NARROW [] synonym: "positive regulation of late stripe melanophore differentiation" EXACT [] synonym: "stimulation of late stripe melanocyte differentiation" NARROW [] synonym: "up regulation of late stripe melanocyte differentiation" EXACT [] synonym: "up-regulation of late stripe melanocyte differentiation" EXACT [] synonym: "upregulation of late stripe melanocyte differentiation" EXACT [] is_a: GO:0045636 ! positive regulation of melanocyte differentiation is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation relationship: positively_regulates GO:0050934 ! late stripe melanocyte differentiation [Term] id: GO:0050951 name: sensory perception of temperature stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "sensory perception of thermal stimulus" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050952 name: sensory perception of electrical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050953 name: sensory perception of light stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050954 name: sensory perception of mechanical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanosensory perception" EXACT [] synonym: "perception of mechanical stimulus" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050955 name: thermoception namespace: biological_process def: "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature)." [GOC:ai, http://www.wikipedia.org/Thermoception] synonym: "thermoreception" EXACT [] xref: Wikipedia:Thermoception is_a: GO:0050951 ! sensory perception of temperature stimulus [Term] id: GO:0050956 name: electroception namespace: biological_process def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, http://www.wikipedia.org/Electroreception, PMID:10210663] synonym: "electroception sense" EXACT [] synonym: "electroceptive sense" EXACT [] xref: Wikipedia:Electroreception is_a: GO:0050952 ! sensory perception of electrical stimulus [Term] id: GO:0050957 name: equilibrioception namespace: biological_process def: "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [http://www.medterms.com, http://www.onelook.com/] synonym: "sensory perception of orientation with respect to gravity" EXACT [] xref: Wikipedia:Equilibrioception is_a: GO:0007600 ! sensory perception relationship: part_of GO:0050885 ! neuromuscular process controlling balance [Term] id: GO:0050958 name: magnetoreception namespace: biological_process def: "The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, http://www.wikipedia.org/Magnetoception, PMID:15886990] synonym: "magnetoception" EXACT [] synonym: "sensory perception of magnetic field" EXACT [] xref: Wikipedia:Magnetoception is_a: GO:0007600 ! sensory perception [Term] id: GO:0050959 name: echolocation namespace: biological_process def: "Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning." [http://www.onelook.com/, http://www.wikipedia.org/Animal_echolocation, PMID:16005275] synonym: "perception of environment using reflected sound waves" EXACT [] xref: Wikipedia:Echolocation is_a: GO:0050877 ! neurological system process [Term] id: GO:0050960 name: detection of temperature stimulus involved in thermoception namespace: biological_process def: "The series of events v thermoception in which a sensory temperature stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "sensory detection of heat stimulus during thermoception" NARROW [] synonym: "sensory detection of temperature stimulus during thermoception" EXACT [] synonym: "sensory detection of thermal stimulus during thermoception" EXACT [] synonym: "sensory transduction of heat stimulus during thermoception" NARROW [] synonym: "sensory transduction of temperature stimulus during thermoception" EXACT [] synonym: "sensory transduction of thermal stimulus during thermoception" EXACT [] synonym: "thermoception, sensory detection of heat stimulus" NARROW [] synonym: "thermoception, sensory detection of temperature stimulus" EXACT [] synonym: "thermoception, sensory detection of thermal stimulus" EXACT [] synonym: "thermoception, sensory transduction of heat stimulus" NARROW [] synonym: "thermoception, sensory transduction of temperature stimulus" EXACT [] synonym: "thermoception, sensory transduction of thermal stimulus" EXACT [] is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception relationship: part_of GO:0050955 ! thermoception [Term] id: GO:0050961 name: detection of temperature stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a sensory temperature stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "sensory detection of heat stimulus during sensory perception" NARROW [] synonym: "sensory detection of temperature stimulus" EXACT [] synonym: "sensory detection of temperature stimulus during sensory perception" EXACT [] synonym: "sensory detection of thermal stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of heat stimulus" NARROW [] synonym: "sensory perception, sensory detection of temperature stimulus" EXACT [] synonym: "sensory perception, sensory detection of thermal stimulus" EXACT [] synonym: "sensory perception, sensory transduction of heat stimulus" NARROW [] synonym: "sensory perception, sensory transduction of temperature stimulus" EXACT [] synonym: "sensory perception, sensory transduction of thermal stimulus" EXACT [] synonym: "sensory transduction of heat stimulus during sensory perception" NARROW [] synonym: "sensory transduction of temperature stimulus" EXACT [] synonym: "sensory transduction of temperature stimulus during sensory perception" EXACT [] synonym: "sensory transduction of thermal stimulus during sensory perception" EXACT [] is_a: GO:0016048 ! detection of temperature stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception relationship: part_of GO:0050951 ! sensory perception of temperature stimulus [Term] id: GO:0050962 name: detection of light stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a sensory light stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "sensory detection of light stimulus" EXACT [] synonym: "sensory detection of light stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of light stimulus" EXACT [] synonym: "sensory perception, sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus during sensory perception" EXACT [] is_a: GO:0009583 ! detection of light stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception relationship: part_of GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0050963 name: detection of electrical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a sensory electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "sensory detection of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of electrical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory transduction of electrical stimulus" EXACT [] synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT [] is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0050981 ! detection of electrical stimulus relationship: part_of GO:0050952 ! sensory perception of electrical stimulus [Term] id: GO:0050964 name: detection of electrical stimulus involved in electroception namespace: biological_process def: "The series of events that contribute to electroception in which a sensory electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "detection of electrical stimulus during electroreception" RELATED [GOC:dph, GOC:tb] synonym: "electroception, detection of electrical stimulus" EXACT [] synonym: "electroception, sensory detection of electrical stimulus" EXACT [] synonym: "electroception, sensory transduction" EXACT [] synonym: "electroception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during electroception" RELATED [] synonym: "sensory transduction of electrical stimulus during electroception" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception relationship: part_of GO:0050956 ! electroception [Term] id: GO:0050965 name: detection of temperature stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a sensory temperature stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "perception of pain, detection of temperature stimulus" EXACT [] synonym: "perception of pain, sensory detection of temperature stimulus" EXACT [] synonym: "perception of pain, sensory transduction of temperature stimulus" EXACT [] synonym: "sensory detection of temperature stimulus during perception of pain" EXACT [] synonym: "sensory detection of thermal stimulus during sensory perception of pain" EXACT [] synonym: "sensory perception of pain, sensory detection of thermal stimulus" EXACT [] synonym: "sensory perception of pain, sensory transduction of thermal stimulus" EXACT [] synonym: "sensory transduction of temperature stimulus during perception of pain" EXACT [] synonym: "sensory transduction of thermal stimulus during sensory perception of pain" EXACT [] is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception relationship: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050966 name: detection of mechanical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "perception of pain, detection of mechanical stimulus" EXACT [] synonym: "perception of pain, sensory detection of mechanical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during perception of pain" EXACT [] synonym: "sensory transduction of mechanical stimulus during perception of pain" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050967 name: detection of electrical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events that contribute to the perception of pain in which a sensory electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai, GOC:dph, GOC:tb] synonym: "detection of electrical stimulus during sensory perception of pain" RELATED [GOC:dph, GOC:tb] synonym: "perception of pain, detection of electrical stimulus" EXACT [] synonym: "perception of pain, sensory detection of electrical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during perception of pain" RELATED [] synonym: "sensory transduction of electrical stimulus during perception of pain" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception relationship: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050968 name: detection of chemical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a sensory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "perception of pain, detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of pain" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception relationship: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050969 name: detection of chemical stimulus involved in magnetoreception namespace: biological_process def: "The series of events involved in magnetoception in which a sensory chemical stimulus is received by a cell and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states." [GOC:ai] synonym: "magnetoception, sensory transduction of chemical stimulus" EXACT [] synonym: "magnetoreception, detection of chemical stimulus" EXACT [] synonym: "magnetoreception, sensory detection of chemical stimulus" EXACT [] synonym: "magnetoreception, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during magnetoreception" EXACT [] synonym: "sensory transduction of chemical stimulus during magnetoreception" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception relationship: part_of GO:0050977 ! magnetoreception by sensory perception of chemical stimulus [Term] id: GO:0050970 name: detection of electrical stimulus involved in magnetoreception namespace: biological_process def: "The series of events that contribute to magnetoception in which a sensory electrical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field." [GOC:ai, GOC:dph, GOC:tb, http://www.wikipedia.org/Magnetoception, PMID:15886990] synonym: "detection of electrical stimulus during magnetoreception" RELATED [GOC:dph, GOC:tb] synonym: "magnetoception, sensory transduction of electrical stimulus" EXACT [] synonym: "magnetoreception, detection of electrical stimulus" EXACT [] synonym: "magnetoreception, sensory detection of electrical stimulus" EXACT [] synonym: "magnetoreception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during magnetoreception" RELATED [] synonym: "sensory transduction of electrical stimulus during magnetoreception" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception relationship: part_of GO:0050978 ! magnetoreception by sensory perception of electrical stimulus [Term] id: GO:0050971 name: detection of mechanical stimulus involved in magnetoreception namespace: biological_process def: "The series of events involved in magnetoception in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field." [GOC:ai] synonym: "magnetoception, sensory transduction of mechanical stimulus" EXACT [] synonym: "magnetoreception, detection of mechanical stimulus" EXACT [] synonym: "magnetoreception, sensory detection of mechanical stimulus" EXACT [] synonym: "magnetoreception, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during magnetoreception" EXACT [] synonym: "sensory transduction of mechanical stimulus during magnetoreception" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: part_of GO:0050979 ! magnetoreception by sensory perception of mechanical stimulus [Term] id: GO:0050972 name: detection of mechanical stimulus involved in echolocation namespace: biological_process def: "The series of events involved in echolocation in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave." [GOC:ai] synonym: "echolocation, detection of mechanical stimulus" EXACT [] synonym: "echolocation, sensory detection of mechanical stimulus" EXACT [] synonym: "echolocation, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during echolocation" EXACT [] synonym: "sensory transduction of mechanical stimulus during echolocation" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: part_of GO:0050959 ! echolocation [Term] id: GO:0050973 name: detection of mechanical stimulus involved in equilibrioception namespace: biological_process def: "The series of events involved in equilibrioception in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai] synonym: "equilibrioception, detection of mechanical stimulus" EXACT [] synonym: "equilibrioception, sensory detection of mechanical stimulus" EXACT [] synonym: "equilibrioception, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during equilibrioception" EXACT [] synonym: "sensory transduction of mechanical stimulus during equilibrioception" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: part_of GO:0050957 ! equilibrioception [Term] id: GO:0050974 name: detection of mechanical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "sensory detection of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of mechanical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory transduction of mechanical stimulus during sensory perception" EXACT [] is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0050975 name: sensory perception of touch namespace: biological_process def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] synonym: "perception of touch" EXACT [] synonym: "tactile sense" EXACT [] synonym: "taction" EXACT [] synonym: "tactition" EXACT [] xref: Wikipedia:Touch is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0050976 name: detection of mechanical stimulus involved in sensory perception of touch namespace: biological_process def: "The series of events involved in the perception of touch in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "perception of touch, detection of mechanical stimulus" EXACT [] synonym: "perception of touch, sensory detection of mechanical stimulus" EXACT [] synonym: "perception of touch, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during perception of touch" EXACT [] synonym: "sensory transduction of mechanical stimulus during perception of touch" EXACT [] synonym: "tactition, sensory detection of mechanical stimulus" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: part_of GO:0050975 ! sensory perception of touch [Term] id: GO:0050977 name: magnetoreception by sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli." [GOC:ai, http://www.wikipedia.org/Magnetoception, PMID:15886990] synonym: "magnetoreception by chemical stimulus" EXACT [] synonym: "magnetoreception through chemical stimulus" EXACT [] synonym: "magnetoreception, sensory perception of chemical stimulus" EXACT [] synonym: "magnetoreception, using chemical stimulus" EXACT [GOC:dph, GOC:tb] is_a: GO:0007606 ! sensory perception of chemical stimulus is_a: GO:0050958 ! magnetoreception [Term] id: GO:0050978 name: magnetoreception by sensory perception of electrical stimulus namespace: biological_process def: "The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish." [GOC:ai, http://www.wikipedia.org/Magnetoception, PMID:15886990] synonym: "magnetoreception by electrical stimulus" EXACT [] synonym: "magnetoreception through electrical stimulus" EXACT [] synonym: "magnetoreception, sensory perception of electrical stimulus" EXACT [] synonym: "magnetoreception, using electrical stimulus" EXACT [GOC:dph, GOC:tb] is_a: GO:0050952 ! sensory perception of electrical stimulus is_a: GO:0050958 ! magnetoreception [Term] id: GO:0050979 name: magnetoreception by sensory perception of mechanical stimulus namespace: biological_process def: "The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field." [GOC:ai, http://www.wikipedia.org/Magnetoception, PMID:15886990] synonym: "magnetoreception by sensory perception of mechanical stimulus" EXACT [] synonym: "magnetoreception through mechanical stimulus" EXACT [] synonym: "magnetoreception, sensory perception of mechanical stimulus" EXACT [] synonym: "magnetoreception, using mechanical stimulus" EXACT [GOC:dph, GOC:tb] is_a: GO:0050954 ! sensory perception of mechanical stimulus is_a: GO:0050958 ! magnetoreception [Term] id: GO:0050980 name: detection of light stimulus involved in magnetoreception namespace: biological_process def: "The series of events involved in magnetoception in which a light stimulus is received by a cell and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, http://www.wikipedia.org/Magnetoception, PMID:15886990] synonym: "magnetoreception, detection of light stimulus" EXACT [] synonym: "magnetoreception, sensory detection of light stimulus" EXACT [] synonym: "magnetoreception, sensory transduction of light stimulus" EXACT [] synonym: "sensory detection of light stimulus during magnetoreception" EXACT [] synonym: "sensory transduction of light stimulus during magnetoreception" EXACT [] is_a: GO:0050962 ! detection of light stimulus involved in sensory perception relationship: part_of GO:0050958 ! magnetoreception [Term] id: GO:0050981 name: detection of electrical stimulus namespace: biological_process def: "The series of events by which an electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0051602 ! response to electrical stimulus [Term] id: GO:0050982 name: detection of mechanical stimulus namespace: biological_process def: "The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0050983 name: spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase namespace: biological_process def: "The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN] comment: Note that this reaction is catalyzed by a single enzyme but since it has multiple steps, it appears in the process ontology. subset: gosubset_prok synonym: "(4-aminobutyl)lysine synthase activity" RELATED [EC:2.5.1.46] synonym: "[eIF-5A]-deoxyhypusine synthase activity" RELATED [EC:2.5.1.46] synonym: "spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase" EXACT [] synonym: "spermidine degradation to deoxyhypusine, using deoxyhypusine synthase" EXACT [] xref: EC:2.5.1.46 xref: MetaCyc:2.5.1.46-RXN is_a: GO:0046203 ! spermidine catabolic process [Term] id: GO:0050984 name: peptidyl-serine sulfation namespace: biological_process def: "The sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine." [RESID:AA0361] subset: gosubset_prok xref: RESID:AA0361 is_a: GO:0006477 ! protein sulfation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0050985 name: peptidyl-threonine sulfation namespace: biological_process def: "The sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine." [RESID:AA0362] subset: gosubset_prok xref: RESID:AA0362 is_a: GO:0006477 ! protein sulfation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0050986 name: isopeptide cross-linking via N-(L-isoglutamyl)-glycine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25." [PMID:14531691, RESID:AA0360] subset: gosubset_prok xref: RESID:AA0360 is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0050987 name: enzyme active site formation via O-sulfo-L-serine namespace: biological_process def: "The transient sulfation of peptidyl-serine to form O-sulfo-L-serine." [RESID:AA0361] subset: gosubset_prok xref: RESID:AA0361 is_a: GO:0018307 ! enzyme active site formation is_a: GO:0050984 ! peptidyl-serine sulfation [Term] id: GO:0050988 name: N-terminal peptidyl-methionine carboxylation namespace: biological_process def: "The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine." [RESID:AA0363] subset: gosubset_prok xref: RESID:AA0363 is_a: GO:0018206 ! peptidyl-methionine modification is_a: GO:0050989 ! N-terminal protein amino acid carboxylation [Term] id: GO:0050989 name: N-terminal protein amino acid carboxylation namespace: biological_process def: "The carboxylation of the N-terminal amino acid of proteins." [GOC:ai] subset: gosubset_prok is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0050990 name: N-terminal protein amino acid carbamoylation namespace: biological_process def: "The carbamoylation of the N-terminal amino acid of proteins." [GOC:ai] subset: gosubset_prok synonym: "N-terminal protein amino acid carbamylation" EXACT [] is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0050991 name: enzyme active site formation via O-sulfo-L-threonine namespace: biological_process def: "The transient sulfation of peptidyl-threonine to form O-sulfo-L-threonine." [RESID:AA0362] subset: gosubset_prok xref: RESID:AA0362 is_a: GO:0018307 ! enzyme active site formation is_a: GO:0050985 ! peptidyl-threonine sulfation [Term] id: GO:0050992 name: dimethylallyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate." [GOC:ai] subset: gosubset_prok synonym: "dimethylallyl diphosphate anabolism" EXACT [] synonym: "dimethylallyl diphosphate biosynthesis" EXACT [] synonym: "dimethylallyl diphosphate formation" EXACT [] synonym: "dimethylallyl diphosphate synthesis" EXACT [] synonym: "dimethylallyl pyrophosphate biosynthesis" EXACT [] synonym: "dimethylallyl pyrophosphate biosynthetic process" EXACT [] synonym: "DPP biosynthesis" EXACT [] synonym: "DPP biosynthetic process" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016091 ! prenol biosynthetic process is_a: GO:0050993 ! dimethylallyl diphosphate metabolic process [Term] id: GO:0050993 name: dimethylallyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethylallyl diphosphate." [GOC:ai] subset: gosubset_prok synonym: "dimethylallyl diphosphate metabolism" EXACT [] synonym: "dimethylallyl pyrophosphate metabolic process" EXACT [] synonym: "dimethylallyl pyrophosphate metabolism" EXACT [] synonym: "DPP metabolic process" EXACT [] synonym: "DPP metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0016090 ! prenol metabolic process [Term] id: GO:0050994 name: regulation of lipid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "regulation of lipid breakdown" EXACT [] synonym: "regulation of lipid catabolism" EXACT [] synonym: "regulation of lipid degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0019216 ! regulation of lipid metabolic process relationship: regulates GO:0016042 ! lipid catabolic process [Term] id: GO:0050995 name: negative regulation of lipid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "down regulation of lipid catabolic process" EXACT [] synonym: "down-regulation of lipid catabolic process" EXACT [] synonym: "downregulation of lipid catabolic process" EXACT [] synonym: "inhibition of lipid catabolic process" NARROW [] synonym: "negative regulation of lipid breakdown" EXACT [] synonym: "negative regulation of lipid catabolism" EXACT [] synonym: "negative regulation of lipid degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process relationship: negatively_regulates GO:0016042 ! lipid catabolic process [Term] id: GO:0050996 name: positive regulation of lipid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "activation of lipid catabolic process" NARROW [] synonym: "positive regulation of lipid breakdown" EXACT [] synonym: "positive regulation of lipid catabolism" EXACT [] synonym: "positive regulation of lipid degradation" EXACT [] synonym: "stimulation of lipid catabolic process" NARROW [] synonym: "up regulation of lipid catabolic process" EXACT [] synonym: "up-regulation of lipid catabolic process" EXACT [] synonym: "upregulation of lipid catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process relationship: positively_regulates GO:0016042 ! lipid catabolic process [Term] id: GO:0050997 name: quaternary ammonium group binding namespace: molecular_function def: "Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai] subset: gosubset_prok synonym: "quaternary amine binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0050998 name: nitric-oxide synthase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme nitric-oxide synthase." [GOC:ai] synonym: "NOS binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0050999 name: regulation of nitric-oxide synthase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme nitric-oxide synthase." [GOC:ai] subset: gosubset_prok synonym: "nitric-oxide synthase regulator" EXACT [] synonym: "NOS regulator" EXACT [] synonym: "regulation of NOS activity" EXACT [] xref: Reactome:1253540 "eNOS activation" xref: Reactome:1253541 "eNOS activation and regulation" xref: Reactome:1253546 "NOSIP mediated eNOS trafficking" xref: Reactome:1253547 "NOSTRIN mediated eNOS trafficking" xref: Reactome:1280479 "eNOS activation" xref: Reactome:1280480 "eNOS activation and regulation" xref: Reactome:1280485 "NOSIP mediated eNOS trafficking" xref: Reactome:1280486 "NOSTRIN mediated eNOS trafficking" xref: Reactome:1299303 "eNOS activation" xref: Reactome:1299304 "eNOS activation and regulation" xref: Reactome:1299314 "NOSIP mediated eNOS trafficking" xref: Reactome:1299315 "NOSTRIN mediated eNOS trafficking" xref: Reactome:1327057 "eNOS activation" xref: Reactome:1327058 "eNOS activation and regulation" xref: Reactome:1327065 "NOSIP mediated eNOS trafficking" xref: Reactome:1327066 "NOSTRIN mediated eNOS trafficking" xref: Reactome:1353151 "eNOS activation" xref: Reactome:1353152 "eNOS activation and regulation" xref: Reactome:1353159 "NOSIP mediated eNOS trafficking" xref: Reactome:1353160 "NOSTRIN mediated eNOS trafficking" xref: Reactome:1417847 "eNOS activation" xref: Reactome:1417848 "eNOS activation and regulation" xref: Reactome:1417855 "NOSIP mediated eNOS trafficking" xref: Reactome:1417856 "NOSTRIN mediated eNOS trafficking" xref: Reactome:1450942 "NOSTRIN mediated eNOS trafficking" xref: Reactome:1450943 "eNOS activation and regulation" xref: Reactome:1471324 "eNOS activation" xref: Reactome:1471325 "eNOS activation and regulation" xref: Reactome:1521239 "eNOS activation" xref: Reactome:1521240 "eNOS activation and regulation" xref: Reactome:1538066 "eNOS activation" xref: Reactome:1538067 "eNOS activation and regulation" xref: Reactome:1540350 "eNOS activation" xref: Reactome:1540351 "eNOS activation and regulation" xref: Reactome:203615 "eNOS activation" xref: Reactome:203641 "NOSTRIN mediated eNOS trafficking" xref: Reactome:203754 "NOSIP mediated eNOS trafficking" xref: Reactome:203765 "eNOS activation and regulation" is_a: GO:0032768 ! regulation of monooxygenase activity [Term] id: GO:0051000 name: positive regulation of nitric-oxide synthase activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme nitric-oxide synthase." [GOC:ai] subset: gosubset_prok synonym: "activation of nitric-oxide synthase activity" NARROW [] synonym: "nitric-oxide synthase activator" EXACT [] synonym: "NOS activator" EXACT [] synonym: "positive regulation of NOS activity" EXACT [] synonym: "stimulation of nitric-oxide synthase activity" NARROW [] synonym: "up regulation of nitric-oxide synthase activity" EXACT [] synonym: "up-regulation of nitric-oxide synthase activity" EXACT [] synonym: "upregulation of nitric-oxide synthase activity" EXACT [] is_a: GO:0032770 ! positive regulation of monooxygenase activity is_a: GO:0050999 ! regulation of nitric-oxide synthase activity [Term] id: GO:0051001 name: negative regulation of nitric-oxide synthase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme nitric-oxide synthase." [GOC:ai] subset: gosubset_prok synonym: "down regulation of nitric-oxide synthase activity" EXACT [] synonym: "down-regulation of nitric-oxide synthase activity" EXACT [] synonym: "downregulation of nitric-oxide synthase activity" EXACT [] synonym: "inhibition of nitric-oxide synthase activity" NARROW [] synonym: "negative regulation of NOS activity" EXACT [] synonym: "nitric-oxide synthase inhibitor" NARROW [] synonym: "NOS inhibitor" NARROW [] is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:0050999 ! regulation of nitric-oxide synthase activity [Term] id: GO:0051002 name: ligase activity, forming nitrogen-metal bonds namespace: molecular_function def: "Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.6, GOC:mah] subset: gosubset_prok xref: EC:6.6 is_a: GO:0016874 ! ligase activity [Term] id: GO:0051003 name: ligase activity, forming nitrogen-metal bonds, forming coordination complexes namespace: molecular_function def: "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex." [EC:6.6.1.-] subset: gosubset_prok xref: EC:6.6.1 is_a: GO:0051002 ! ligase activity, forming nitrogen-metal bonds [Term] id: GO:0051004 name: regulation of lipoprotein lipase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme lipoprotein lipase." [GOC:ai] subset: gosubset_prok is_a: GO:0060191 ! regulation of lipase activity [Term] id: GO:0051005 name: negative regulation of lipoprotein lipase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme lipoprotein lipase." [GOC:ai] subset: gosubset_prok synonym: "down regulation of lipoprotein lipase activity" EXACT [] synonym: "down-regulation of lipoprotein lipase activity" EXACT [] synonym: "downregulation of lipoprotein lipase activity" EXACT [] synonym: "inhibition of lipoprotein lipase activity" NARROW [] is_a: GO:0051004 ! regulation of lipoprotein lipase activity is_a: GO:0060192 ! negative regulation of lipase activity [Term] id: GO:0051006 name: positive regulation of lipoprotein lipase activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme lipoprotein lipase." [GOC:ai] subset: gosubset_prok synonym: "activation of lipoprotein lipase activity" NARROW [] synonym: "stimulation of lipoprotein lipase activity" NARROW [] synonym: "up regulation of lipoprotein lipase activity" EXACT [] synonym: "up-regulation of lipoprotein lipase activity" EXACT [] synonym: "upregulation of lipoprotein lipase activity" EXACT [] is_a: GO:0051004 ! regulation of lipoprotein lipase activity is_a: GO:0060193 ! positive regulation of lipase activity [Term] id: GO:0051007 name: squalene-hopene cyclase activity namespace: molecular_function def: "Catalysis of the reaction: squalene = hop-22(29)-ene." [EC:5.4.99.17] subset: gosubset_prok synonym: "squalene mutase (cyclizing)" EXACT [EC:5.4.99.17] synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99.17 xref: MetaCyc:5.4.99.17-RXN is_a: GO:0016866 ! intramolecular transferase activity is_a: GO:0034072 ! squalene cyclase activity [Term] id: GO:0051008 name: Hsp27 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Hsp27 proteins, a lightweight heat shock protein." [GOC:ai] is_a: GO:0031072 ! heat shock protein binding [Term] id: GO:0051009 name: O-acetylhomoserine sulfhydrylase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN] xref: MetaCyc:ACETYLHOMOSER-CYS-RXN is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0051010 name: microtubule plus-end binding namespace: molecular_function def: "Interacting selectively and non-covalently with the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] is_a: GO:0008017 ! microtubule binding [Term] id: GO:0051011 name: microtubule minus-end binding namespace: molecular_function def: "Interacting selectively and non-covalently with the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] is_a: GO:0008017 ! microtubule binding [Term] id: GO:0051012 name: microtubule sliding namespace: biological_process def: "The movement of one microtubule along another microtubule." [PMID:14557818, PMID:14614826] synonym: "microtubule translocation" EXACT [] is_a: GO:0007018 ! microtubule-based movement [Term] id: GO:0051013 name: microtubule severing namespace: biological_process def: "The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234] synonym: "microtubule severing activity" RELATED [] is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0051014 name: actin filament severing namespace: biological_process def: "The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234] synonym: "actin filament severing activity" RELATED [] synonym: "barbed-end actin capping/severing activity" RELATED [] synonym: "F-actin severing" EXACT [] is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0051015 name: actin filament binding namespace: molecular_function def: "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "actin cross-linking activity" RELATED [] synonym: "F-actin binding" EXACT [] is_a: GO:0003779 ! actin binding [Term] id: GO:0051016 name: barbed-end actin filament capping namespace: biological_process def: "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] synonym: "barbed-end actin capping activity" EXACT [] synonym: "barbed-end F-actin capping activity" EXACT [] synonym: "plus-end actin filament capping activity" EXACT [] synonym: "plus-end F-actin capping activity" EXACT [] is_a: GO:0051693 ! actin filament capping [Term] id: GO:0051017 name: actin filament bundle assembly namespace: biological_process alt_id: GO:0045011 def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] synonym: "actin bundling activity" RELATED [] synonym: "actin cable assembly" RELATED [GOC:mah] synonym: "actin cable formation" RELATED [GOC:mah] is_a: GO:0007015 ! actin filament organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0051018 name: protein kinase A binding namespace: molecular_function def: "Interacting selectively and non-covalently with any subunit of protein kinase A." [GOC:ai] comment: Note that this term is a direct child of 'protein binding ; GO:0005515' because it encompasses binding to either the catalytic or regulatory subunit of protein kinase A, and the latter does not have kinase activity. synonym: "PKA binding" EXACT [] synonym: "protein kinase A anchoring activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051019 name: mitogen-activated protein kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase." [GOC:ai] synonym: "MAP kinase binding" EXACT [] synonym: "MAP-kinase anchoring activity" RELATED [] synonym: "MAPK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0051020 name: GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0051021 name: GDP-dissociation inhibitor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a GDP-dissociation inhibitor protein." [GOC:ai] synonym: "GDI binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051022 name: Rho GDP-dissociation inhibitor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein." [GOC:ai] synonym: "Rho GDI binding" EXACT [] is_a: GO:0051021 ! GDP-dissociation inhibitor binding [Term] id: GO:0051023 name: regulation of immunoglobulin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells." [GOC:ai] synonym: "regulation of antibody secretion" EXACT [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0050708 ! regulation of protein secretion relationship: regulates GO:0048305 ! immunoglobulin secretion [Term] id: GO:0051024 name: positive regulation of immunoglobulin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells." [GOC:ai] synonym: "activation of immunoglobulin secretion" NARROW [] synonym: "positive regulation of antibody secretion" EXACT [] synonym: "stimulation of immunoglobulin secretion" NARROW [] synonym: "up regulation of immunoglobulin secretion" EXACT [] synonym: "up-regulation of immunoglobulin secretion" EXACT [] synonym: "upregulation of immunoglobulin secretion" EXACT [] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0051023 ! regulation of immunoglobulin secretion relationship: positively_regulates GO:0048305 ! immunoglobulin secretion [Term] id: GO:0051025 name: negative regulation of immunoglobulin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells." [GOC:ai] synonym: "down regulation of immunoglobulin secretion" EXACT [] synonym: "down-regulation of immunoglobulin secretion" EXACT [] synonym: "downregulation of immunoglobulin secretion" EXACT [] synonym: "inhibition of immunoglobulin secretion" NARROW [] synonym: "negative regulation of antibody secretion" EXACT [] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0051023 ! regulation of immunoglobulin secretion relationship: negatively_regulates GO:0048305 ! immunoglobulin secretion [Term] id: GO:0051026 name: chiasma assembly namespace: biological_process def: "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [http://www.onelook.com] is_a: GO:0022402 ! cell cycle process is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0051027 name: DNA transport namespace: biological_process def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0050657 ! nucleic acid transport [Term] id: GO:0051028 name: mRNA transport namespace: biological_process def: "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport [Term] id: GO:0051029 name: rRNA transport namespace: biological_process def: "The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport [Term] id: GO:0051030 name: snRNA transport namespace: biological_process def: "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport [Term] id: GO:0051031 name: tRNA transport namespace: biological_process def: "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport [Term] id: GO:0051032 name: nucleic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai] is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity [Term] id: GO:0051033 name: RNA transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai] xref: Reactome:160488 "RNA transmembrane transporter activity" is_a: GO:0051032 ! nucleic acid transmembrane transporter activity [Term] id: GO:0051034 name: tRNA transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0051033 ! RNA transmembrane transporter activity [Term] id: GO:0051035 name: DNA transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0051032 ! nucleic acid transmembrane transporter activity [Term] id: GO:0051036 name: regulation of endosome size namespace: biological_process def: "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis." [GOC:ai] synonym: "endosome enlargement" RELATED [] is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0051037 name: regulation of transcription during meiosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription during meiosis." [GOC:go_curators] synonym: "meiotic regulation of transcription" EXACT [] synonym: "regulation of transcription, meiotic" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-dependent [Term] id: GO:0051038 name: negative regulation of transcription during meiosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription during meiosis." [GOC:ai] synonym: "down regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "down-regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "downregulation of transcription during meiosis" EXACT [GOC:mah] synonym: "inhibition of transcription during meiosis" NARROW [GOC:mah] synonym: "meiotic repression of transcription" EXACT [] synonym: "negative regulation of meiotic transcription" EXACT [] synonym: "negative regulation of transcription, meiotic" EXACT [GOC:mah] is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent is_a: GO:0051037 ! regulation of transcription during meiosis [Term] id: GO:0051039 name: positive regulation of transcription during meiosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription during meiosis." [GOC:ai] synonym: "activation of transcription during meiosis" NARROW [GOC:mah] synonym: "positive regulation of meiotic transcription" EXACT [] synonym: "positive regulation of transcription, meiotic" EXACT [GOC:mah] synonym: "stimulation of transcription during meiosis" NARROW [GOC:mah] synonym: "up regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "up-regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "upregulation of transcription during meiosis" EXACT [GOC:mah] is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent is_a: GO:0051037 ! regulation of transcription during meiosis [Term] id: GO:0051040 name: regulation of calcium-independent cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:ai] is_a: GO:0022407 ! regulation of cell-cell adhesion relationship: regulates GO:0016338 ! calcium-independent cell-cell adhesion [Term] id: GO:0051041 name: positive regulation of calcium-independent cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai] synonym: "activation of calcium-independent cell-cell adhesion" NARROW [] synonym: "stimulation of calcium-independent cell-cell adhesion" NARROW [] synonym: "up regulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "up-regulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "upregulation of calcium-independent cell-cell adhesion" EXACT [] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion relationship: positively_regulates GO:0016338 ! calcium-independent cell-cell adhesion [Term] id: GO:0051042 name: negative regulation of calcium-independent cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai] synonym: "down regulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "down-regulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "downregulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "inhibition of calcium-independent cell-cell adhesion" NARROW [] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion relationship: negatively_regulates GO:0016338 ! calcium-independent cell-cell adhesion [Term] id: GO:0051043 name: regulation of membrane protein ectodomain proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:ai] subset: gosubset_prok is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process relationship: regulates GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051044 name: positive regulation of membrane protein ectodomain proteolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis." [GOC:ai] subset: gosubset_prok synonym: "activation of membrane protein ectodomain proteolysis" NARROW [] synonym: "stimulation of membrane protein ectodomain proteolysis" NARROW [] synonym: "up regulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "up-regulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "upregulation of membrane protein ectodomain proteolysis" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis relationship: positively_regulates GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051045 name: negative regulation of membrane protein ectodomain proteolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai] subset: gosubset_prok synonym: "down regulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "down-regulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "downregulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "inhibition of membrane protein ectodomain proteolysis" NARROW [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis relationship: negatively_regulates GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051046 name: regulation of secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells." [GOC:ai] subset: gosubset_prok is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0046903 ! secretion [Term] id: GO:0051047 name: positive regulation of secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or group of cells." [GOC:ai] synonym: "activation of secretion" NARROW [] synonym: "stimulation of secretion" NARROW [] synonym: "up regulation of secretion" EXACT [] synonym: "up-regulation of secretion" EXACT [] synonym: "upregulation of secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0046903 ! secretion [Term] id: GO:0051048 name: negative regulation of secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or group of cells." [GOC:ai] synonym: "down regulation of secretion" EXACT [] synonym: "down-regulation of secretion" EXACT [] synonym: "downregulation of secretion" EXACT [] synonym: "inhibition of secretion" NARROW [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0046903 ! secretion [Term] id: GO:0051049 name: regulation of transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0032879 ! regulation of localization relationship: regulates GO:0006810 ! transport [Term] id: GO:0051050 name: positive regulation of transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "activation of transport" NARROW [] synonym: "stimulation of transport" NARROW [] synonym: "up regulation of transport" EXACT [] synonym: "up-regulation of transport" EXACT [] synonym: "upregulation of transport" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport relationship: positively_regulates GO:0006810 ! transport [Term] id: GO:0051051 name: negative regulation of transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "down regulation of transport" EXACT [] synonym: "down-regulation of transport" EXACT [] synonym: "downregulation of transport" EXACT [] synonym: "inhibition of transport" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051049 ! regulation of transport relationship: negatively_regulates GO:0006810 ! transport [Term] id: GO:0051052 name: regulation of DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: gosubset_prok synonym: "regulation of DNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0006259 ! DNA metabolic process [Term] id: GO:0051053 name: negative regulation of DNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: gosubset_prok synonym: "down regulation of DNA metabolic process" EXACT [] synonym: "down-regulation of DNA metabolic process" EXACT [] synonym: "downregulation of DNA metabolic process" EXACT [] synonym: "inhibition of DNA metabolic process" NARROW [] synonym: "negative regulation of DNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process relationship: negatively_regulates GO:0006259 ! DNA metabolic process [Term] id: GO:0051054 name: positive regulation of DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: gosubset_prok synonym: "activation of DNA metabolic process" NARROW [] synonym: "positive regulation of DNA metabolism" EXACT [] synonym: "stimulation of DNA metabolic process" NARROW [] synonym: "up regulation of DNA metabolic process" EXACT [] synonym: "up-regulation of DNA metabolic process" EXACT [] synonym: "upregulation of DNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process relationship: positively_regulates GO:0006259 ! DNA metabolic process [Term] id: GO:0051055 name: negative regulation of lipid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] subset: gosubset_prok synonym: "down regulation of lipid biosynthetic process" EXACT [] synonym: "down-regulation of lipid biosynthetic process" EXACT [] synonym: "downregulation of lipid biosynthetic process" EXACT [] synonym: "inhibition of lipid biosynthetic process" NARROW [] synonym: "negative regulation of lipid anabolism" EXACT [] synonym: "negative regulation of lipid biosynthesis" EXACT [] synonym: "negative regulation of lipid formation" EXACT [] synonym: "negative regulation of lipid synthesis" EXACT [] synonym: "negative regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: negatively_regulates GO:0008610 ! lipid biosynthetic process [Term] id: GO:0051056 name: regulation of small GTPase mediated signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] synonym: "regulation of small GTPase-mediated signal transduction" EXACT [] xref: Reactome:1253495 "Rho GTPase cycle" xref: Reactome:1280434 "Rho GTPase cycle" xref: Reactome:1299266 "Rho GTPase cycle" xref: Reactome:1327012 "Rho GTPase cycle" xref: Reactome:1353106 "Rho GTPase cycle" xref: Reactome:1373295 "Rho GTPase cycle" xref: Reactome:1393308 "Rho GTPase cycle" xref: Reactome:1417806 "Rho GTPase cycle" xref: Reactome:1450904 "Rho GTPase cycle" xref: Reactome:1471285 "Rho GTPase cycle" xref: Reactome:1483258 "Rho GTPase cycle" xref: Reactome:1496935 "Rho GTPase cycle" xref: Reactome:1514322 "Rho GTPase cycle" xref: Reactome:1521190 "Rho GTPase cycle" xref: Reactome:1526935 "Rho GTPase cycle" xref: Reactome:1532674 "Rho GTPase cycle" xref: Reactome:194840 "Rho GTPase cycle" is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0051057 name: positive regulation of small GTPase mediated signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai] synonym: "activation of small GTPase mediated signal transduction" NARROW [] synonym: "positive regulation of small GTPase-mediated signal transduction" EXACT [] synonym: "stimulation of small GTPase mediated signal transduction" NARROW [] synonym: "up regulation of small GTPase mediated signal transduction" EXACT [] synonym: "up-regulation of small GTPase mediated signal transduction" EXACT [] synonym: "upregulation of small GTPase mediated signal transduction" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction relationship: positively_regulates GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0051058 name: negative regulation of small GTPase mediated signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai] synonym: "down regulation of small GTPase mediated signal transduction" EXACT [] synonym: "down-regulation of small GTPase mediated signal transduction" EXACT [] synonym: "downregulation of small GTPase mediated signal transduction" EXACT [] synonym: "inhibition of small GTPase mediated signal transduction" NARROW [] synonym: "negative regulation of small GTPase-mediated signal transduction" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction relationship: negatively_regulates GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0051059 name: NF-kappaB binding namespace: molecular_function def: "Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0051060 name: pullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1,6)-a-D-glucosidic linkages in pullulan [a linear polymer of a-(1,6)-linked maltotriose units] and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen." [EC:3.2.1.41] subset: gosubset_prok synonym: "alpha-dextrin endo-1,6-alpha-glucosidase activity" EXACT [] synonym: "amylopectin 6-glucanohydrolase activity" EXACT [] synonym: "bacterial debranching enzyme" RELATED [EC:3.2.1.41] synonym: "debranching enzyme activity" BROAD [EC:3.2.1.41] synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.41] synonym: "pullulan 6-glucanohydrolase activity" EXACT [] synonym: "pullulan alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.41] synonym: "R-enzyme" RELATED [EC:3.2.1.41] xref: EC:3.2.1.41 xref: MetaCyc:RXN-1824 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0051061 name: ADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN] synonym: "ADP reduction" RELATED [] xref: MetaCyc:ADPREDUCT-RXN is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity [Term] id: GO:0051062 name: UDP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN] synonym: "UDP reduction" RELATED [] xref: MetaCyc:UDPREDUCT-RXN is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity [Term] id: GO:0051063 name: CDP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin." [MetaCyc:CDPREDUCT-RXN] synonym: "CDP reduction" RELATED [] xref: MetaCyc:CDPREDUCT-RXN is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity [Term] id: GO:0051064 name: TTP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] synonym: "TTP reduction" RELATED [] xref: EC:1.17.4.- is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity [Term] id: GO:0051065 name: CTP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] synonym: "CTP reduction" RELATED [] xref: EC:1.17.4.- is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity [Term] id: GO:0051066 name: dihydrobiopterin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions." [CHEBI:38797, http://www.onelook.com] subset: gosubset_prok synonym: "6,7-dihydrobiopterin metabolic process" NARROW [CHEBI:20680, GOC:curators] synonym: "7,8-dihydrobiopterin metabolic process" NARROW [CHEBI:15375, GOC:curators] synonym: "dihydrobiopterin reduction" NARROW [GOC:curators] synonym: "dihydropterin metabolic process" EXACT [CHEBI:38797] synonym: "dihydropterin metabolism" EXACT [GOC:curators] is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0051067 name: dihydropteridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4." [CHEBI:30156, GOC:ai] subset: gosubset_prok synonym: "6,7-dihydropteridine metabolic process" EXACT [CHEBI:30156, GOC:curators] synonym: "dihydropteridine metabolism" EXACT [] synonym: "dihydropteridine reduction" NARROW [] is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0051068 name: dihydrolipoamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor." [ISBN:0721601464] subset: gosubset_prok synonym: "dihydrolipoamide metabolism" EXACT [] synonym: "dihydrolipoamide reduction" NARROW [] synonym: "dihydrothioctamide metabolic process" EXACT [] synonym: "dihydrothioctamide metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0051069 name: galactomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units." [http://www.els.net/els/public/glossary/] subset: gosubset_prok synonym: "galactomannan metabolism" EXACT [] is_a: GO:0006080 ! substituted mannan metabolic process [Term] id: GO:0051070 name: galactomannan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai] subset: gosubset_prok synonym: "galactomannan anabolism" EXACT [] synonym: "galactomannan biosynthesis" EXACT [] synonym: "galactomannan formation" EXACT [] synonym: "galactomannan synthesis" EXACT [] is_a: GO:0046354 ! mannan biosynthetic process is_a: GO:0051069 ! galactomannan metabolic process [Term] id: GO:0051071 name: 4,6-pyruvylated galactose residue metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185] subset: gosubset_prok synonym: "4,6-pyruvylated galactose residue metabolism" EXACT [] synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process" EXACT [] synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism" EXACT [] synonym: "PvGal metabolic process" EXACT [] synonym: "PvGal metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0051072 name: 4,6-pyruvylated galactose residue biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185] subset: gosubset_prok synonym: "4,6-pyruvylated galactose residue anabolism" EXACT [] synonym: "4,6-pyruvylated galactose residue biosynthesis" EXACT [] synonym: "4,6-pyruvylated galactose residue formation" EXACT [] synonym: "4,6-pyruvylated galactose residue synthesis" EXACT [] synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis" EXACT [] synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process" EXACT [] synonym: "PvGal biosynthesis" EXACT [] synonym: "PvGal biosynthetic process" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0051071 ! 4,6-pyruvylated galactose residue metabolic process [Term] id: GO:0051073 name: adenosylcobinamide-GDP ribazoletransferase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin." [EC:2.7.8.26, MetaCyc:COBALAMINSYN-RXN] synonym: "adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity" EXACT [EC:2.7.8.26] synonym: "cobalamin (5'-phosphate) synthase activity" EXACT [EC:2.7.8.26] synonym: "cobalamin synthase activity" EXACT [] synonym: "cobalamin-5'-phosphate synthase activity" EXACT [EC:2.7.8.26] synonym: "CobS" RELATED [EC:2.7.8.26] xref: EC:2.7.8.26 xref: MetaCyc:COBALAMINSYN-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0051074 name: protein tetramerization activity namespace: molecular_function def: "OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd] comment: This term was made obsolete because it represents a process. is_obsolete: true replaced_by: GO:0051262 [Term] id: GO:0051075 name: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA." [PMID:12731872] subset: gosubset_prok synonym: "S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity" EXACT [] is_a: GO:0016740 ! transferase activity is_a: GO:0016853 ! isomerase activity [Term] id: GO:0051077 name: secondary cell septum namespace: cellular_component def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814] synonym: "secondary septum" BROAD [] is_a: GO:0030428 ! cell septum [Term] id: GO:0051078 name: meiotic nuclear envelope disassembly namespace: biological_process def: "The cell cycle process in which the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf] synonym: "meiotic nuclear envelope breakdown" EXACT [] synonym: "meiotic nuclear envelope catabolism" EXACT [] synonym: "meiotic nuclear envelope degradation" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051081 ! nuclear envelope disassembly relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051079 name: meiosis I nuclear envelope disassembly namespace: biological_process def: "The controlled breakdown of the nuclear envelope during the first division of meiosis." [GOC:bf] synonym: "meiosis I nuclear envelope breakdown" EXACT [] synonym: "meiosis I nuclear envelope catabolism" EXACT [] synonym: "meiosis I nuclear envelope degradation" EXACT [] is_a: GO:0051078 ! meiotic nuclear envelope disassembly relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0051080 name: meiosis II nuclear envelope disassembly namespace: biological_process def: "The controlled breakdown of the nuclear envelope during the second division of meiosis." [GOC:bf] synonym: "meiosis II nuclear envelope breakdown" EXACT [] synonym: "meiosis II nuclear envelope catabolism" EXACT [] synonym: "meiosis II nuclear envelope degradation" EXACT [] is_a: GO:0051078 ! meiotic nuclear envelope disassembly relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0051081 name: nuclear envelope disassembly namespace: biological_process def: "The controlled breakdown of the nuclear envelope in the context of a normal process." [GOC:ai] synonym: "nuclear envelope breakdown" EXACT [] synonym: "nuclear envelope catabolism" EXACT [] synonym: "nuclear envelope degradation" EXACT [] is_a: GO:0006998 ! nuclear envelope organization is_a: GO:0030397 ! membrane disassembly [Term] id: GO:0051082 name: unfolded protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with an unfolded protein." [GOC:ai] subset: gosubset_prok synonym: "binding unfolded ER proteins" NARROW [] synonym: "chaperone activity" RELATED [] synonym: "fimbrium-specific chaperone activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "histone-specific chaperone activity" RELATED [] synonym: "ribosomal chaperone activity" RELATED [] synonym: "tubulin-specific chaperone activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051083 name: 'de novo' cotranslational protein folding namespace: biological_process alt_id: GO:0006444 def: "The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated." [GOC:rb] subset: gosubset_prok synonym: "'de novo' co-translational protein folding" EXACT [] synonym: "multidomain protein assembly" EXACT [] synonym: "nascent polypeptide association" EXACT [] is_a: GO:0006458 ! 'de novo' protein folding [Term] id: GO:0051084 name: 'de novo' posttranslational protein folding namespace: biological_process def: "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] subset: gosubset_prok synonym: "'de novo' post-translational protein folding" EXACT [] xref: Reactome:1253679 "Protein folding" xref: Reactome:1280611 "Protein folding" xref: Reactome:1299442 "Protein folding" xref: Reactome:1327196 "Protein folding" xref: Reactome:1353291 "Protein folding" xref: Reactome:1373468 "Protein folding" xref: Reactome:1393489 "Protein folding" xref: Reactome:1417989 "Protein folding" xref: Reactome:1451076 "Protein folding" xref: Reactome:1471434 "Protein folding" xref: Reactome:1483385 "Protein folding" xref: Reactome:1497049 "Protein folding" xref: Reactome:1514436 "Protein folding" xref: Reactome:1521299 "Protein folding" xref: Reactome:1527007 "Protein folding" xref: Reactome:1532744 "Protein folding" xref: Reactome:1536129 "Protein folding" xref: Reactome:391251 "Protein folding" is_a: GO:0006458 ! 'de novo' protein folding [Term] id: GO:0051085 name: chaperone mediated protein folding requiring cofactor namespace: biological_process def: "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] subset: gosubset_prok synonym: "chaperone co-factor-dependent protein folding" EXACT [] synonym: "chaperone cofactor-dependent 'de novo' protein folding" EXACT [GOC:mah] synonym: "chaperone cofactor-dependent protein folding" EXACT [GOC:rb] is_a: GO:0051084 ! 'de novo' posttranslational protein folding is_a: GO:0061077 ! chaperone-mediated protein folding [Term] id: GO:0051086 name: chaperone mediated protein folding independent of cofactor namespace: biological_process def: "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] subset: gosubset_prok synonym: "chaperone cofactor-independent protein folding" EXACT [GOC:rb] xref: Reactome:1253683 "Folding of actin by CCT/TriC" xref: Reactome:1280615 "Folding of actin by CCT/TriC" xref: Reactome:1299446 "Folding of actin by CCT/TriC" xref: Reactome:1327200 "Folding of actin by CCT/TriC" xref: Reactome:1353295 "Folding of actin by CCT/TriC" xref: Reactome:1373471 "Folding of actin by CCT/TriC" xref: Reactome:1393492 "Folding of actin by CCT/TriC" xref: Reactome:1417993 "Folding of actin by CCT/TriC" xref: Reactome:1451080 "Folding of actin by CCT/TriC" xref: Reactome:1471439 "Folding of actin by CCT/TriC" xref: Reactome:1483388 "Folding of actin by CCT/TriC" xref: Reactome:1497053 "Folding of actin by CCT/TriC" xref: Reactome:1514440 "Folding of actin by CCT/TriC" xref: Reactome:1521303 "Folding of actin by CCT/TriC" xref: Reactome:1527012 "Folding of actin by CCT/TriC" xref: Reactome:1532747 "Folding of actin by CCT/TriC" xref: Reactome:1536131 "Folding of actin by CCT/TriC" xref: Reactome:390450 "Folding of actin by CCT/TriC" xref: Reactome:392030 "Folding of actin by CCT/TriC" is_a: GO:0051084 ! 'de novo' posttranslational protein folding is_a: GO:0061077 ! chaperone-mediated protein folding [Term] id: GO:0051087 name: chaperone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com] subset: gosubset_prok synonym: "chaperone protein binding" EXACT [] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051088 name: PMA-inducible membrane protein ectodomain proteolysis namespace: biological_process def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist." [PMID:12714508] is_a: GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051089 name: constitutive protein ectodomain proteolysis namespace: biological_process def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands." [PMID:12714508] subset: gosubset_prok is_a: GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051090 name: regulation of sequence-specific DNA binding transcription factor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] subset: gosubset_prok synonym: "regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb] xref: Reactome:1253359 "Activation of the AP-1 family of transcription factors" xref: Reactome:1280299 "Activation of the AP-1 family of transcription factors" xref: Reactome:1299151 "Activation of the AP-1 family of transcription factors" xref: Reactome:1326877 "Activation of the AP-1 family of transcription factors" xref: Reactome:1352969 "Activation of the AP-1 family of transcription factors" xref: Reactome:1373170 "Activation of the AP-1 family of transcription factors" xref: Reactome:1393181 "Activation of the AP-1 family of transcription factors" xref: Reactome:1417673 "Activation of the AP-1 family of transcription factors" xref: Reactome:1450775 "Activation of the AP-1 family of transcription factors" xref: Reactome:1471519 "Activation of the AP-1 family of transcription factors" xref: Reactome:1532633 "Activation of the AP-1 family of transcription factors" xref: Reactome:450341 "Activation of the AP-1 family of transcription factors" is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0051091 name: positive regulation of sequence-specific DNA binding transcription factor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] subset: gosubset_prok synonym: "activation of transcription factor activity" NARROW [] synonym: "positive regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb] synonym: "stimulation of transcription factor activity" NARROW [] synonym: "up regulation of transcription factor activity" EXACT [] synonym: "up-regulation of transcription factor activity" EXACT [] synonym: "upregulation of transcription factor activity" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051090 ! regulation of sequence-specific DNA binding transcription factor activity [Term] id: GO:0051092 name: positive regulation of NF-kappaB transcription factor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030] synonym: "activation of NF-kappaB" EXACT [] synonym: "activation of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "NF-kappaB activation" EXACT [] xref: Reactome:1253362 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex" xref: Reactome:1280302 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex" xref: Reactome:1299154 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex" xref: Reactome:1326880 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex" xref: Reactome:1352972 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex" xref: Reactome:1417677 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex" xref: Reactome:1450778 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex" xref: Reactome:445989 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex" is_a: GO:0051091 ! positive regulation of sequence-specific DNA binding transcription factor activity [Term] id: GO:0051093 name: negative regulation of developmental process namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] subset: gosubset_prok synonym: "down regulation of developmental process" EXACT [] synonym: "down-regulation of developmental process" EXACT [] synonym: "downregulation of developmental process" EXACT [] synonym: "inhibition of developmental process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050793 ! regulation of developmental process relationship: negatively_regulates GO:0032502 ! developmental process [Term] id: GO:0051094 name: positive regulation of developmental process namespace: biological_process def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] subset: gosubset_prok synonym: "activation of developmental process" NARROW [] synonym: "stimulation of developmental process" NARROW [] synonym: "up regulation of developmental process" EXACT [] synonym: "up-regulation of developmental process" EXACT [] synonym: "upregulation of developmental process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process relationship: positively_regulates GO:0032502 ! developmental process [Term] id: GO:0051095 name: regulation of helicase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of helicase activity." [GOC:ai] subset: gosubset_prok is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0051096 name: positive regulation of helicase activity namespace: biological_process def: "Any process that activates or increases the activity of a helicase." [GOC:ai] subset: gosubset_prok synonym: "activation of helicase activity" NARROW [] synonym: "stimulation of helicase activity" NARROW [] synonym: "up regulation of helicase activity" EXACT [] synonym: "up-regulation of helicase activity" EXACT [] synonym: "upregulation of helicase activity" EXACT [] is_a: GO:0051095 ! regulation of helicase activity is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0051097 name: negative regulation of helicase activity namespace: biological_process def: "Any process that stops or reduces the activity of a helicase." [GOC:ai] subset: gosubset_prok synonym: "down regulation of helicase activity" EXACT [] synonym: "down-regulation of helicase activity" EXACT [] synonym: "downregulation of helicase activity" EXACT [] synonym: "inhibition of helicase activity" NARROW [] is_a: GO:0051095 ! regulation of helicase activity is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0051098 name: regulation of binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] subset: gosubset_prok is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0051099 name: positive regulation of binding namespace: biological_process def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] subset: gosubset_prok synonym: "activation of binding" NARROW [] synonym: "stimulation of binding" NARROW [] synonym: "up regulation of binding" EXACT [] synonym: "up-regulation of binding" EXACT [] synonym: "upregulation of binding" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051098 ! regulation of binding [Term] id: GO:0051100 name: negative regulation of binding namespace: biological_process def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] subset: gosubset_prok synonym: "down regulation of binding" EXACT [] synonym: "down-regulation of binding" EXACT [] synonym: "downregulation of binding" EXACT [] synonym: "inhibition of binding" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051098 ! regulation of binding [Term] id: GO:0051101 name: regulation of DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:0051098 ! regulation of binding [Term] id: GO:0051102 name: DNA ligation involved in DNA recombination namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination." [GOC:ai] subset: gosubset_prok synonym: "DNA ligation during DNA recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0006266 ! DNA ligation relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0051103 name: DNA ligation involved in DNA repair namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai] subset: gosubset_prok synonym: "DNA ligation during DNA repair" RELATED [GOC:dph, GOC:tb] is_a: GO:0006266 ! DNA ligation relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0051104 name: DNA ligation involved in DNA-dependent DNA replication namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA-dependent DNA replication." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "DNA ligation during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] is_a: GO:0006266 ! DNA ligation relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0051105 name: regulation of DNA ligation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolic process relationship: regulates GO:0006266 ! DNA ligation [Term] id: GO:0051106 name: positive regulation of DNA ligation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] subset: gosubset_prok synonym: "activation of DNA ligation" NARROW [] synonym: "stimulation of DNA ligation" NARROW [] synonym: "up regulation of DNA ligation" EXACT [] synonym: "up-regulation of DNA ligation" EXACT [] synonym: "upregulation of DNA ligation" EXACT [] is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:0051105 ! regulation of DNA ligation relationship: positively_regulates GO:0006266 ! DNA ligation [Term] id: GO:0051107 name: negative regulation of DNA ligation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] subset: gosubset_prok synonym: "down regulation of DNA ligation" EXACT [] synonym: "down-regulation of DNA ligation" EXACT [] synonym: "downregulation of DNA ligation" EXACT [] synonym: "inhibition of DNA ligation" NARROW [] is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:0051105 ! regulation of DNA ligation relationship: negatively_regulates GO:0006266 ! DNA ligation [Term] id: GO:0051108 name: carnitine-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA." [MetaCyc:DCARNCOALIG-RXN] synonym: "carnitine synthetase activity" EXACT [] synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] xref: MetaCyc:DCARNCOALIG-RXN is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0051109 name: crotonobetaine-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA." [MetaCyc:CROTCOALIG-RXN] synonym: "crotonobetaine-CoA synthase activity" EXACT [] synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] xref: MetaCyc:CROTCOALIG-RXN is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0051110 name: peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine namespace: biological_process def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372] subset: gosubset_prok xref: RESID:AA0372 is_a: GO:0051114 ! peptidyl-histidine uridylylation [Term] id: GO:0051111 name: peptidyl-histidine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine)." [RESID:AA0371] subset: gosubset_prok xref: RESID:AA0371 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0051112 name: peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine namespace: biological_process def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371] subset: gosubset_prok xref: RESID:AA0371 is_a: GO:0051111 ! peptidyl-histidine adenylylation [Term] id: GO:0051113 name: enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine namespace: biological_process def: "The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371] subset: gosubset_prok xref: RESID:AA0371 is_a: GO:0018307 ! enzyme active site formation is_a: GO:0051112 ! peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine [Term] id: GO:0051114 name: peptidyl-histidine uridylylation namespace: biological_process def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine)." [RESID:AA0372] subset: gosubset_prok xref: RESID:AA0372 is_a: GO:0018177 ! protein uridylylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0051115 name: enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine namespace: biological_process def: "The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372] subset: gosubset_prok xref: RESID:AA0372 is_a: GO:0018307 ! enzyme active site formation is_a: GO:0051110 ! peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine [Term] id: GO:0051116 name: cobaltochelatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + Co(2+) + H(2)O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H(+) + phosphate." [EC:6.6.1.2, RHEA:15344] subset: gosubset_prok synonym: "CobN-CobST" RELATED [EC:6.6.1.2] synonym: "CobNST" NARROW [] synonym: "hydrogenobyrinic acid a,c-diamide cobaltochelatase activity" EXACT [] synonym: "hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)" EXACT [EC:6.6.1.2] xref: EC:6.6.1.2 xref: KEGG:R05227 xref: MetaCyc:R342-RXN xref: RHEA:15344 is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes [Term] id: GO:0051117 name: ATPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0051118 name: glucan endo-1,3-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." [EC:3.2.1.59] synonym: "1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.59] synonym: "cariogenanase activity" EXACT [EC:3.2.1.59] synonym: "cariogenase activity" EXACT [EC:3.2.1.59] synonym: "endo-(1->3)-alpha-glucanase activity" EXACT [EC:3.2.1.59] synonym: "endo-1,3-alpha-D-glucanase activity" EXACT [EC:3.2.1.59] synonym: "endo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.59] synonym: "mutanase activity" EXACT [EC:3.2.1.59] xref: EC:3.2.1.59 xref: MetaCyc:3.2.1.59-RXN is_a: GO:0004558 ! alpha-glucosidase activity [Term] id: GO:0051119 name: sugar transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sugar/polyol channel activity" NARROW [] xref: Reactome:160010 "sugar transmembrane transporter activity" is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0051120 name: hepoxilin A3 synthase activity namespace: molecular_function def: "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3." [PMID:15123652] is_a: GO:0016853 ! isomerase activity [Term] id: GO:0051121 name: hepoxilin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [PMID:15123652] subset: gosubset_prok synonym: "hepoxilin metabolism" EXACT [] is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0051122 name: hepoxilin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [GOC:ai] subset: gosubset_prok synonym: "hepoxilin anabolism" EXACT [] synonym: "hepoxilin biosynthesis" EXACT [] synonym: "hepoxilin formation" EXACT [] synonym: "hepoxilin synthesis" EXACT [] is_a: GO:0046456 ! icosanoid biosynthetic process is_a: GO:0051121 ! hepoxilin metabolic process [Term] id: GO:0051123 name: RNA polymerase II transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047] synonym: "RNA polymerase II transcription PIC biosynthesis" EXACT [] synonym: "RNA polymerase II transcription PIC formation" EXACT [] synonym: "RNA polymerase II transcriptional preinitiation complex formation" EXACT [] is_a: GO:0070897 ! DNA-dependent transcriptional preinitiation complex assembly relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0051124 name: synaptic growth at neuromuscular junction namespace: biological_process def: "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "cholinergic synaptogenesis" RELATED [] is_a: GO:0007416 ! synapse assembly is_a: GO:0007528 ! neuromuscular junction development is_a: GO:0048589 ! developmental growth [Term] id: GO:0051125 name: regulation of actin nucleation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] is_a: GO:0032956 ! regulation of actin cytoskeleton organization relationship: regulates GO:0045010 ! actin nucleation [Term] id: GO:0051126 name: negative regulation of actin nucleation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] synonym: "down regulation of actin nucleation" EXACT [] synonym: "down-regulation of actin nucleation" EXACT [] synonym: "downregulation of actin nucleation" EXACT [] synonym: "inhibition of actin nucleation" NARROW [] is_a: GO:0051125 ! regulation of actin nucleation is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0045010 ! actin nucleation [Term] id: GO:0051127 name: positive regulation of actin nucleation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] synonym: "activation of actin nucleation" NARROW [] synonym: "stimulation of actin nucleation" NARROW [] synonym: "up regulation of actin nucleation" EXACT [] synonym: "up-regulation of actin nucleation" EXACT [] synonym: "upregulation of actin nucleation" EXACT [] is_a: GO:0051125 ! regulation of actin nucleation is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0045010 ! actin nucleation [Term] id: GO:0051128 name: regulation of cellular component organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] subset: gosubset_prok synonym: "regulation of cell organisation" RELATED [GOC:mah] synonym: "regulation of cell organization" RELATED [GOC:mah] synonym: "regulation of cellular component organisation" EXACT [GOC:curators] synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0016043 ! cellular component organization [Term] id: GO:0051129 name: negative regulation of cellular component organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] subset: gosubset_prok synonym: "down regulation of cell organization" EXACT [] synonym: "down-regulation of cell organization" EXACT [] synonym: "downregulation of cell organization" EXACT [] synonym: "inhibition of cell organization" NARROW [] synonym: "negative regulation of cell organisation" RELATED [GOC:mah] synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051128 ! regulation of cellular component organization relationship: negatively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051130 name: positive regulation of cellular component organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "activation of cell organization" NARROW [] synonym: "positive regulation of cell organisation" EXACT [] synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell organization" NARROW [] synonym: "up regulation of cell organization" EXACT [] synonym: "up-regulation of cell organization" EXACT [] synonym: "upregulation of cell organization" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051128 ! regulation of cellular component organization relationship: positively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051131 name: chaperone-mediated protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] subset: gosubset_prok synonym: "chaperone activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0051132 name: NK T cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments. synonym: "natural killer T cell activation" EXACT [] synonym: "natural T cell activation" EXACT [] synonym: "NK T lymphocyte activation" EXACT [] synonym: "NK T-cell activation" EXACT [] synonym: "NK T-lymphocyte activation" EXACT [] synonym: "NKT cell activation" EXACT [] synonym: "NT cell activation" EXACT [] is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0051133 name: regulation of NK T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] synonym: "regulation of natural killer T cell activation" EXACT [] synonym: "regulation of natural T cell activation" EXACT [] synonym: "regulation of NK T lymphocyte activation" EXACT [] synonym: "regulation of NK T-cell activation" EXACT [] synonym: "regulation of NK T-lymphocyte activation" EXACT [] synonym: "regulation of NKT cell activation" EXACT [] synonym: "regulation of NT cell activation" EXACT [] is_a: GO:0046634 ! regulation of alpha-beta T cell activation relationship: regulates GO:0051132 ! NK T cell activation [Term] id: GO:0051134 name: negative regulation of NK T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] synonym: "down regulation of NK T cell activation" EXACT [] synonym: "down-regulation of NK T cell activation" EXACT [] synonym: "downregulation of NK T cell activation" EXACT [] synonym: "inhibition of NK T cell activation" NARROW [] synonym: "negative regulation of natural killer T cell activation" EXACT [] synonym: "negative regulation of natural T cell activation" EXACT [] synonym: "negative regulation of NK T lymphocyte activation" EXACT [] synonym: "negative regulation of NK T-cell activation" EXACT [] synonym: "negative regulation of NK T-lymphocyte activation" EXACT [] synonym: "negative regulation of NKT cell activation" EXACT [] synonym: "negative regulation of NT cell activation" EXACT [] is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:0051133 ! regulation of NK T cell activation relationship: negatively_regulates GO:0051132 ! NK T cell activation [Term] id: GO:0051135 name: positive regulation of NK T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] synonym: "activation of NK T cell activation" NARROW [] synonym: "positive regulation of natural killer T cell activation" EXACT [] synonym: "positive regulation of natural T cell activation" EXACT [] synonym: "positive regulation of NK T lymphocyte activation" EXACT [] synonym: "positive regulation of NK T-cell activation" EXACT [] synonym: "positive regulation of NK T-lymphocyte activation" EXACT [] synonym: "positive regulation of NKT cell activation" EXACT [] synonym: "positive regulation of NT cell activation" EXACT [] synonym: "stimulation of NK T cell activation" NARROW [] synonym: "up regulation of NK T cell activation" EXACT [] synonym: "up-regulation of NK T cell activation" EXACT [] synonym: "upregulation of NK T cell activation" EXACT [] is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0051133 ! regulation of NK T cell activation relationship: positively_regulates GO:0051132 ! NK T cell activation [Term] id: GO:0051136 name: regulation of NK T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer T cell differentiation" EXACT [] synonym: "regulation of natural T cell differentiation" EXACT [] synonym: "regulation of NK T cell development" RELATED [GOC:add] synonym: "regulation of NK T lymphocyte differentiation" EXACT [] synonym: "regulation of NK T-cell differentiation" EXACT [] synonym: "regulation of NK T-lymphocyte differentiation" EXACT [] synonym: "regulation of NKT cell differentiation" EXACT [] synonym: "regulation of NT cell differentiation" EXACT [] is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation relationship: regulates GO:0001865 ! NK T cell differentiation [Term] id: GO:0051137 name: negative regulation of NK T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of NK T cell differentiation" EXACT [] synonym: "down-regulation of NK T cell differentiation" EXACT [] synonym: "downregulation of NK T cell differentiation" EXACT [] synonym: "inhibition of NK T cell differentiation" NARROW [] synonym: "negative regulation of natural killer T cell differentiation" EXACT [] synonym: "negative regulation of natural T cell differentiation" EXACT [] synonym: "negative regulation of NK T cell development" RELATED [GOC:add] synonym: "negative regulation of NK T lymphocyte differentiation" EXACT [] synonym: "negative regulation of NK T-cell differentiation" EXACT [] synonym: "negative regulation of NK T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of NKT cell differentiation" EXACT [] synonym: "negative regulation of NT cell differentiation" EXACT [] is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation is_a: GO:0051136 ! regulation of NK T cell differentiation relationship: negatively_regulates GO:0001865 ! NK T cell differentiation [Term] id: GO:0051138 name: positive regulation of NK T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of NK T cell differentiation" NARROW [] synonym: "positive regulation of natural killer T cell differentiation" EXACT [] synonym: "positive regulation of natural T cell differentiation" EXACT [] synonym: "positive regulation of NK T cell development" RELATED [GOC:add] synonym: "positive regulation of NK T lymphocyte differentiation" EXACT [] synonym: "positive regulation of NK T-cell differentiation" EXACT [] synonym: "positive regulation of NK T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of NKT cell differentiation" EXACT [] synonym: "positive regulation of NT cell differentiation" EXACT [] synonym: "stimulation of NK T cell differentiation" NARROW [] synonym: "up regulation of NK T cell differentiation" EXACT [] synonym: "up-regulation of NK T cell differentiation" EXACT [] synonym: "upregulation of NK T cell differentiation" EXACT [] is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:0051136 ! regulation of NK T cell differentiation relationship: positively_regulates GO:0001865 ! NK T cell differentiation [Term] id: GO:0051139 name: metal ion:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg] subset: gosubset_prok synonym: "metal ion:proton antiporter activity" EXACT [] xref: Reactome:161488 "metal ion:hydrogen antiporter activity" is_a: GO:0015299 ! solute:hydrogen antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0051140 name: regulation of NK T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] synonym: "regulation of natural killer T cell proliferation" EXACT [] synonym: "regulation of natural T cell proliferation" EXACT [] synonym: "regulation of NK T lymphocyte proliferation" EXACT [] synonym: "regulation of NK T-cell proliferation" EXACT [] synonym: "regulation of NK T-lymphocyte proliferation" EXACT [] synonym: "regulation of NKT cell proliferation" EXACT [] synonym: "regulation of NT cell proliferation" EXACT [] is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation relationship: regulates GO:0001866 ! NK T cell proliferation [Term] id: GO:0051141 name: negative regulation of NK T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] synonym: "down regulation of NK T cell proliferation" EXACT [] synonym: "down-regulation of NK T cell proliferation" EXACT [] synonym: "downregulation of NK T cell proliferation" EXACT [] synonym: "inhibition of NK T cell proliferation" NARROW [] synonym: "negative regulation of natural killer T cell proliferation" EXACT [] synonym: "negative regulation of natural T cell proliferation" EXACT [] synonym: "negative regulation of NK T lymphocyte proliferation" EXACT [] synonym: "negative regulation of NK T-cell proliferation" EXACT [] synonym: "negative regulation of NK T-lymphocyte proliferation" EXACT [] synonym: "negative regulation of NKT cell proliferation" EXACT [] synonym: "negative regulation of NT cell proliferation" EXACT [] is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation is_a: GO:0051140 ! regulation of NK T cell proliferation relationship: negatively_regulates GO:0001866 ! NK T cell proliferation [Term] id: GO:0051142 name: positive regulation of NK T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] synonym: "activation of NK T cell proliferation" NARROW [] synonym: "positive regulation of natural killer T cell proliferation" EXACT [] synonym: "positive regulation of natural T cell proliferation" EXACT [] synonym: "positive regulation of NK T lymphocyte proliferation" EXACT [] synonym: "positive regulation of NK T-cell proliferation" EXACT [] synonym: "positive regulation of NK T-lymphocyte proliferation" EXACT [] synonym: "positive regulation of NKT cell proliferation" EXACT [] synonym: "positive regulation of NT cell proliferation" EXACT [] synonym: "stimulation of NK T cell proliferation" NARROW [] synonym: "up regulation of NK T cell proliferation" EXACT [] synonym: "up-regulation of NK T cell proliferation" EXACT [] synonym: "upregulation of NK T cell proliferation" EXACT [] is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation is_a: GO:0051140 ! regulation of NK T cell proliferation relationship: positively_regulates GO:0001866 ! NK T cell proliferation [Term] id: GO:0051143 name: propanediol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items." [http://www.onelook.com] subset: gosubset_prok synonym: "1,2-dihydroxypropane metabolic process" EXACT [] synonym: "1,2-dihydroxypropane metabolism" EXACT [] synonym: "propanediol metabolism" EXACT [] synonym: "propylene glycol metabolic process" EXACT [] synonym: "propylene glycol metabolism" EXACT [] is_a: GO:0034311 ! diol metabolic process [Term] id: GO:0051144 name: propanediol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH." [GOC:ai] subset: gosubset_prok synonym: "1,2-dihydroxypropane catabolic process" EXACT [] synonym: "1,2-dihydroxypropane catabolism" EXACT [] synonym: "propanediol breakdown" EXACT [] synonym: "propanediol catabolism" EXACT [] synonym: "propanediol degradation" EXACT [] synonym: "propylene glycol catabolic process" EXACT [] synonym: "propylene glycol catabolism" EXACT [] is_a: GO:0034313 ! diol catabolic process is_a: GO:0051143 ! propanediol metabolic process [Term] id: GO:0051145 name: smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] synonym: "nonstriated muscle cell differentiation" EXACT [] is_a: GO:0042692 ! muscle cell differentiation [Term] id: GO:0051146 name: striated muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai] synonym: "voluntary muscle cell differentiation" NARROW [] is_a: GO:0042692 ! muscle cell differentiation [Term] id: GO:0051147 name: regulation of muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0042692 ! muscle cell differentiation [Term] id: GO:0051148 name: negative regulation of muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "down regulation of muscle cell differentiation" EXACT [] synonym: "down-regulation of muscle cell differentiation" EXACT [] synonym: "downregulation of muscle cell differentiation" EXACT [] synonym: "inhibition of muscle cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation relationship: negatively_regulates GO:0042692 ! muscle cell differentiation [Term] id: GO:0051149 name: positive regulation of muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "activation of muscle cell differentiation" NARROW [] synonym: "stimulation of muscle cell differentiation" NARROW [] synonym: "up regulation of muscle cell differentiation" EXACT [] synonym: "up-regulation of muscle cell differentiation" EXACT [] synonym: "upregulation of muscle cell differentiation" EXACT [] xref: Reactome:1253631 "CDO in myogenesis" xref: Reactome:1280563 "CDO in myogenesis" xref: Reactome:1299395 "CDO in myogenesis" xref: Reactome:1327148 "CDO in myogenesis" xref: Reactome:1353243 "CDO in myogenesis" xref: Reactome:1373416 "CDO in myogenesis" xref: Reactome:1393441 "CDO in myogenesis" xref: Reactome:1417943 "CDO in myogenesis" xref: Reactome:1451028 "CDO in myogenesis" xref: Reactome:1471404 "CDO in myogenesis" xref: Reactome:375170 "CDO in myogenesis" is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation relationship: positively_regulates GO:0042692 ! muscle cell differentiation [Term] id: GO:0051150 name: regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation relationship: regulates GO:0051145 ! smooth muscle cell differentiation [Term] id: GO:0051151 name: negative regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "down regulation of smooth muscle cell differentiation" EXACT [] synonym: "down-regulation of smooth muscle cell differentiation" EXACT [] synonym: "downregulation of smooth muscle cell differentiation" EXACT [] synonym: "inhibition of smooth muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation relationship: negatively_regulates GO:0051145 ! smooth muscle cell differentiation [Term] id: GO:0051152 name: positive regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "activation of smooth muscle cell differentiation" NARROW [] synonym: "stimulation of smooth muscle cell differentiation" NARROW [] synonym: "up regulation of smooth muscle cell differentiation" EXACT [] synonym: "up-regulation of smooth muscle cell differentiation" EXACT [] synonym: "upregulation of smooth muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation relationship: positively_regulates GO:0051145 ! smooth muscle cell differentiation [Term] id: GO:0051153 name: regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation relationship: regulates GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0051154 name: negative regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "down regulation of striated muscle cell differentiation" EXACT [] synonym: "down-regulation of striated muscle cell differentiation" EXACT [] synonym: "downregulation of striated muscle cell differentiation" EXACT [] synonym: "inhibition of striated muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation relationship: negatively_regulates GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0051155 name: positive regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "activation of striated muscle cell differentiation" NARROW [] synonym: "stimulation of striated muscle cell differentiation" NARROW [] synonym: "up regulation of striated muscle cell differentiation" EXACT [] synonym: "up-regulation of striated muscle cell differentiation" EXACT [] synonym: "upregulation of striated muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0051156 name: glucose 6-phosphate metabolic process namespace: biological_process alt_id: GO:0006010 def: "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] subset: gosubset_prok synonym: "glucose 6-phosphate metabolism" EXACT [] synonym: "glucose 6-phosphate utilization" RELATED [GOC:mah] is_a: GO:0006006 ! glucose metabolic process [Term] id: GO:0051157 name: arabitol catabolic process namespace: biological_process alt_id: GO:0019591 def: "The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "arabitol breakdown" EXACT [] synonym: "arabitol catabolism" EXACT [] synonym: "arabitol degradation" EXACT [] synonym: "arabitol utilization" RELATED [GOC:mah] is_a: GO:0019527 ! pentitol catabolic process is_a: GO:0051161 ! arabitol metabolic process [Term] id: GO:0051158 name: L-arabitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-arabitol breakdown" EXACT [] synonym: "L-arabitol catabolism" EXACT [] synonym: "L-arabitol degradation" EXACT [] is_a: GO:0051157 ! arabitol catabolic process is_a: GO:0051162 ! L-arabitol metabolic process [Term] id: GO:0051159 name: D-arabitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-arabitol breakdown" EXACT [] synonym: "D-arabitol catabolism" EXACT [] synonym: "D-arabitol degradation" EXACT [] is_a: GO:0051157 ! arabitol catabolic process is_a: GO:0051163 ! D-arabitol metabolic process [Term] id: GO:0051160 name: L-xylitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group." [GOC:ai] subset: gosubset_prok synonym: "L-xylitol breakdown" EXACT [] synonym: "L-xylitol catabolism" EXACT [] synonym: "L-xylitol degradation" EXACT [] is_a: GO:0019527 ! pentitol catabolic process is_a: GO:0051164 ! L-xylitol metabolic process [Term] id: GO:0051161 name: arabitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "arabitol metabolism" EXACT [] is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0051162 name: L-arabitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "L-arabitol metabolism" EXACT [] is_a: GO:0051161 ! arabitol metabolic process [Term] id: GO:0051163 name: D-arabitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-arabitol metabolism" EXACT [] is_a: GO:0051161 ! arabitol metabolic process [Term] id: GO:0051164 name: L-xylitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets." [GOC:ai, http://www.onelook.com] subset: gosubset_prok synonym: "L-xylitol metabolism" EXACT [] is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0051165 name: 2,5-dihydroxypyridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,5-dihydroxypyridine." [CHEBI:16364, GOC:ai] subset: gosubset_prok synonym: "2,5-dihydroxypyridine metabolism" EXACT [] synonym: "pyridine-2,5-diol metabolic process" EXACT [CHEBI:16364] is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0051166 name: 2,5-dihydroxypyridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine." [CHEBI:16364, GOC:ai] subset: gosubset_prok synonym: "2,5-dihydroxypyridine breakdown" EXACT [] synonym: "2,5-dihydroxypyridine catabolism" EXACT [] synonym: "2,5-dihydroxypyridine degradation" EXACT [] synonym: "pyridine-2,5-diol catabolic process" EXACT [CHEBI:16364] is_a: GO:0051165 ! 2,5-dihydroxypyridine metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process [Term] id: GO:0051167 name: xylulose 5-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "D-xylulose 5-phosphate metabolic process" EXACT [] synonym: "D-xylulose 5-phosphate metabolism" EXACT [] synonym: "D-xylulose-5-phosphate metabolic process" EXACT [] synonym: "D-xylulose-5-phosphate metabolism" EXACT [] synonym: "xylulose 5-phosphate metabolism" EXACT [] synonym: "xylulose-5-phosphate metabolic process" EXACT [] synonym: "xylulose-5-phosphate metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0051168 name: nuclear export namespace: biological_process def: "The directed movement of substances out of the nucleus." [GOC:ai] synonym: "export from nucleus" EXACT [] synonym: "nucleus export" EXACT [] synonym: "substance nuclear export" EXACT [] xref: Reactome:1237283 "Nuclear export of snRNA transcripts" xref: Reactome:1264469 "Nuclear export of snRNA transcripts" xref: Reactome:1288871 "Nuclear export of snRNA transcripts" xref: Reactome:1310857 "Nuclear export of snRNA transcripts" xref: Reactome:1337972 "Nuclear export of snRNA transcripts" xref: Reactome:1361608 "Nuclear export of snRNA transcripts" xref: Reactome:1382247 "Nuclear export of snRNA transcripts" xref: Reactome:1403895 "Nuclear export of snRNA transcripts" xref: Reactome:191825 "Nuclear export of snRNA transcripts" is_a: GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0051169 name: nuclear transport namespace: biological_process def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] synonym: "nucleus transport" EXACT [] xref: Reactome:162590 "Import of PIC to the Host Nucleus" xref: Wikipedia:Nuclear_transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0051170 name: nuclear import namespace: biological_process def: "The directed movement of substances into the nucleus." [GOC:ai] synonym: "import into nucleus" EXACT [] synonym: "nucleus import" EXACT [] synonym: "substance nuclear import" EXACT [] xref: Reactome:1264482 "snRNP nuclear import and release" xref: Reactome:1310873 "snRNP nuclear import and release" xref: Reactome:1403914 "snRNP nuclear import and release" xref: Reactome:1432226 "snRNP nuclear import and release" xref: Reactome:191830 "snRNP nuclear import and release" is_a: GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0051171 name: regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] subset: gosubset_prok synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "regulation of nitrogen metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051172 name: negative regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "down regulation of nitrogen metabolic process" EXACT [] synonym: "down-regulation of nitrogen metabolic process" EXACT [] synonym: "downregulation of nitrogen metabolic process" EXACT [] synonym: "inhibition of nitrogen metabolic process" NARROW [] synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "negative regulation of nitrogen metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051173 name: positive regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "activation of nitrogen metabolic process" NARROW [] synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "positive regulation of nitrogen metabolism" EXACT [] synonym: "stimulation of nitrogen metabolic process" NARROW [] synonym: "up regulation of nitrogen metabolic process" EXACT [] synonym: "up-regulation of nitrogen metabolic process" EXACT [] synonym: "upregulation of nitrogen metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051174 name: regulation of phosphorus metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] subset: gosubset_prok synonym: "regulation of phosphorus metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0051175 name: negative regulation of sulfur metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] subset: gosubset_prok synonym: "down regulation of sulfur metabolic process" EXACT [] synonym: "down-regulation of sulfur metabolic process" EXACT [] synonym: "downregulation of sulfur metabolic process" EXACT [] synonym: "inhibition of sulfur metabolic process" NARROW [] synonym: "negative regulation of sulfur metabolism" EXACT [] synonym: "negative regulation of sulphur metabolic process" EXACT [] synonym: "negative regulation of sulphur metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process relationship: negatively_regulates GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0051176 name: positive regulation of sulfur metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] subset: gosubset_prok synonym: "activation of sulfur metabolic process" NARROW [] synonym: "positive regulation of sulfur metabolism" EXACT [] synonym: "positive regulation of sulphur metabolic process" EXACT [] synonym: "positive regulation of sulphur metabolism" EXACT [] synonym: "stimulation of sulfur metabolic process" NARROW [] synonym: "up regulation of sulfur metabolic process" EXACT [] synonym: "up-regulation of sulfur metabolic process" EXACT [] synonym: "upregulation of sulfur metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process relationship: positively_regulates GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0051177 name: meiotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai] is_a: GO:0007062 ! sister chromatid cohesion is_a: GO:0070192 ! chromosome organization involved in meiosis relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051178 name: meiotic chromosome decondensation namespace: biological_process def: "The cell cycle process in which chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai] is_a: GO:0051312 ! chromosome decondensation is_a: GO:0070192 ! chromosome organization involved in meiosis relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051179 name: localization namespace: biological_process def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "establishment and maintenance of cellular component location" NARROW [] synonym: "establishment and maintenance of localization" EXACT [] synonym: "establishment and maintenance of position" EXACT [] synonym: "establishment and maintenance of substance location" NARROW [] synonym: "establishment and maintenance of substrate location" NARROW [] synonym: "localisation" EXACT [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0051180 name: vitamin transport namespace: biological_process def: "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "vitamin or cofactor transport" BROAD [] is_a: GO:0006810 ! transport [Term] id: GO:0051181 name: cofactor transport namespace: biological_process def: "The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "vitamin or cofactor transport" BROAD [] is_a: GO:0006810 ! transport [Term] id: GO:0051182 name: coenzyme transport namespace: biological_process def: "The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] is_a: GO:0051181 ! cofactor transport [Term] id: GO:0051183 name: vitamin transporter activity namespace: molecular_function def: "Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: gosubset_prok synonym: "vitamin or cofactor transporter activity" BROAD [] synonym: "vitamin transmembrane transporter activity" EXACT [GOC:mah] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0051184 name: cofactor transporter activity namespace: molecular_function def: "Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] subset: gosubset_prok synonym: "vitamin or cofactor transporter activity" BROAD [] is_a: GO:0005215 ! transporter activity [Term] id: GO:0051185 name: coenzyme transporter activity namespace: molecular_function def: "Enables the directed movement of a coenzyme into, out of or within a cell, or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0051186 name: cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cofactor metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0051187 name: cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] subset: gosubset_prok synonym: "cofactor breakdown" EXACT [] synonym: "cofactor catabolism" EXACT [] synonym: "cofactor degradation" EXACT [] is_a: GO:0044248 ! cellular catabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0051188 name: cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] subset: gosubset_prok synonym: "cofactor anabolism" EXACT [] synonym: "cofactor biosynthesis" EXACT [] synonym: "cofactor formation" EXACT [] synonym: "cofactor synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0051189 name: prosthetic group metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "prosthetic group metabolism" EXACT [] is_a: GO:0051186 ! cofactor metabolic process relationship: part_of GO:0044267 ! cellular protein metabolic process [Term] id: GO:0051190 name: prosthetic group catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] subset: gosubset_prok synonym: "coenzyme and prosthetic group catabolic process" BROAD [] synonym: "coenzyme and prosthetic group catabolism" BROAD [] synonym: "prosthetic group breakdown" EXACT [] synonym: "prosthetic group catabolism" EXACT [] synonym: "prosthetic group degradation" EXACT [] is_a: GO:0051187 ! cofactor catabolic process is_a: GO:0051189 ! prosthetic group metabolic process relationship: part_of GO:0044257 ! cellular protein catabolic process [Term] id: GO:0051191 name: prosthetic group biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] subset: gosubset_prok synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] synonym: "prosthetic group anabolism" EXACT [] synonym: "prosthetic group biosynthesis" EXACT [] synonym: "prosthetic group formation" EXACT [] synonym: "prosthetic group synthesis" EXACT [] is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0051189 ! prosthetic group metabolic process relationship: part_of GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0051192 name: prosthetic group binding namespace: molecular_function def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules." [GOC:ai] subset: gosubset_prok is_a: GO:0048037 ! cofactor binding [Term] id: GO:0051193 name: regulation of cofactor metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] subset: gosubset_prok synonym: "regulation of cofactor metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0051186 ! cofactor metabolic process [Term] id: GO:0051194 name: positive regulation of cofactor metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] subset: gosubset_prok synonym: "activation of cofactor metabolic process" NARROW [] synonym: "positive regulation of cofactor metabolism" EXACT [] synonym: "stimulation of cofactor metabolic process" NARROW [] synonym: "up regulation of cofactor metabolic process" EXACT [] synonym: "up-regulation of cofactor metabolic process" EXACT [] synonym: "upregulation of cofactor metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process relationship: positively_regulates GO:0051186 ! cofactor metabolic process [Term] id: GO:0051195 name: negative regulation of cofactor metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] subset: gosubset_prok synonym: "down regulation of cofactor metabolic process" EXACT [] synonym: "down-regulation of cofactor metabolic process" EXACT [] synonym: "downregulation of cofactor metabolic process" EXACT [] synonym: "inhibition of cofactor metabolic process" NARROW [] synonym: "negative regulation of cofactor metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process relationship: negatively_regulates GO:0051186 ! cofactor metabolic process [Term] id: GO:0051196 name: regulation of coenzyme metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] subset: gosubset_prok synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "regulation of coenzyme metabolism" EXACT [] is_a: GO:0051193 ! regulation of cofactor metabolic process relationship: regulates GO:0006732 ! coenzyme metabolic process [Term] id: GO:0051197 name: positive regulation of coenzyme metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] subset: gosubset_prok synonym: "activation of coenzyme metabolic process" NARROW [] synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "positive regulation of coenzyme metabolism" EXACT [] synonym: "stimulation of coenzyme metabolic process" NARROW [] synonym: "up regulation of coenzyme metabolic process" EXACT [] synonym: "up-regulation of coenzyme metabolic process" EXACT [] synonym: "upregulation of coenzyme metabolic process" EXACT [] is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process relationship: positively_regulates GO:0006732 ! coenzyme metabolic process [Term] id: GO:0051198 name: negative regulation of coenzyme metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] subset: gosubset_prok synonym: "down regulation of coenzyme metabolic process" EXACT [] synonym: "down-regulation of coenzyme metabolic process" EXACT [] synonym: "downregulation of coenzyme metabolic process" EXACT [] synonym: "inhibition of coenzyme metabolic process" NARROW [] synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "negative regulation of coenzyme metabolism" EXACT [] is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process relationship: negatively_regulates GO:0006732 ! coenzyme metabolic process [Term] id: GO:0051199 name: regulation of prosthetic group metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] subset: gosubset_prok synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "regulation of prosthetic group metabolism" EXACT [] is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process relationship: regulates GO:0051189 ! prosthetic group metabolic process [Term] id: GO:0051200 name: positive regulation of prosthetic group metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] subset: gosubset_prok synonym: "activation of prosthetic group metabolic process" NARROW [] synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "positive regulation of prosthetic group metabolism" EXACT [] synonym: "stimulation of prosthetic group metabolic process" NARROW [] synonym: "up regulation of prosthetic group metabolic process" EXACT [] synonym: "up-regulation of prosthetic group metabolic process" EXACT [] synonym: "upregulation of prosthetic group metabolic process" EXACT [] is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0051199 ! regulation of prosthetic group metabolic process relationship: positively_regulates GO:0051189 ! prosthetic group metabolic process [Term] id: GO:0051201 name: negative regulation of prosthetic group metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] subset: gosubset_prok synonym: "down regulation of prosthetic group metabolic process" EXACT [] synonym: "down-regulation of prosthetic group metabolic process" EXACT [] synonym: "downregulation of prosthetic group metabolic process" EXACT [] synonym: "inhibition of prosthetic group metabolic process" NARROW [] synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "negative regulation of prosthetic group metabolism" EXACT [] is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0051199 ! regulation of prosthetic group metabolic process relationship: negatively_regulates GO:0051189 ! prosthetic group metabolic process [Term] id: GO:0051202 name: phytochromobilin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553] subset: gosubset_prok synonym: "phytochromobilin metabolism" EXACT [] is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0051203 name: peptidyl-aspartic acid reduction to form L-aspartyl aldehyde namespace: biological_process def: "The reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein." [PMID:15237995, RESID:AA0373] comment: See also UniProtKB:P04160. subset: gosubset_prok synonym: "peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde" EXACT [] synonym: "peptidyl-aspartic acid reduction to form L-beta-formylalanine" EXACT [] xref: RESID:AA0373 is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0051204 name: protein insertion into mitochondrial membrane namespace: biological_process def: "The process that results in the incorporation of a protein into a mitochondrial membrane." [GOC:ai] synonym: "integral mitochondrial membrane protein localization" EXACT [] synonym: "integral mitochondrial membrane protein positioning" EXACT [] synonym: "localization of protein in mitochondrial membrane" EXACT [] synonym: "positioning of protein in mitochondrial membrane" EXACT [] synonym: "protein insertion into mitochondrion membrane" EXACT [] synonym: "protein-mitochondrial membrane insertion" EXACT [] synonym: "protein-mitochondrion membrane insertion" EXACT [] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0051205 ! protein insertion into membrane is_a: GO:0072655 ! establishment of protein localization in mitochondrion [Term] id: GO:0051205 name: protein insertion into membrane namespace: biological_process def: "The process that results in the incorporation of a protein into a biological membrane." [GOC:ai] subset: gosubset_prok synonym: "integral membrane protein localization" EXACT [] synonym: "integral membrane protein positioning" EXACT [] synonym: "membrane protein localization" EXACT [] synonym: "membrane protein positioning" EXACT [] synonym: "protein-membrane insertion" EXACT [] is_a: GO:0034613 ! cellular protein localization is_a: GO:0051668 ! localization within membrane relationship: part_of GO:0016044 ! cellular membrane organization [Term] id: GO:0051206 name: silicate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai] subset: gosubset_prok synonym: "silicate metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0051207 name: silicic acid transport namespace: biological_process def: "The directed movement of silicic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Silicic acid, Si(OH)4, is a hydrated form of silicon dioxide that occurs in nature; it is insoluble in water or acids except hydrofluoric acid." [GOC:ai, http://www.onelook.com] is_a: GO:0006810 ! transport [Term] id: GO:0051208 name: sequestering of calcium ion namespace: biological_process def: "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "calcium ion (Ca2+) retention" EXACT [] synonym: "calcium ion (Ca2+) sequestering" EXACT [] synonym: "calcium ion (Ca2+) sequestration" EXACT [] synonym: "calcium ion (Ca2+) storage" EXACT [] synonym: "calcium ion storage activity" RELATED [] synonym: "negative regulation of calcium ion (Ca2+) transport" RELATED [] synonym: "retention of calcium ion (Ca2+)" EXACT [] synonym: "sequestering of calcium ion (Ca2+)" EXACT [] synonym: "sequestration of calcium ion (Ca2+)" EXACT [] synonym: "storage of calcium ion (Ca2+)" EXACT [] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0051209 name: release of sequestered calcium ion into cytosol namespace: biological_process def: "The process in which calcium ions sequestered in the endoplasmic reticulum or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung] synonym: "calcium ion (Ca2+) mobilization" BROAD [] synonym: "calcium mobilization" BROAD [] synonym: "cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] synonym: "cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "cytosolic release of stored calcium ion (Ca2+)" EXACT [] synonym: "release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "release of sequestered calcium ion into cytoplasm" BROAD [] synonym: "release of stored calcium ion (Ca2+)" BROAD [] synonym: "release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] synonym: "release of stored calcium ion (Ca2+) into cytosol" EXACT [] is_a: GO:0051283 ! negative regulation of sequestering of calcium ion is_a: GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0051210 name: isotropic cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth." [GOC:ai, GOC:jid] synonym: "uniform cell growth" RELATED [] is_a: GO:0016049 ! cell growth [Term] id: GO:0051211 name: anisotropic cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell." [GOC:ai] synonym: "non-isotropic cell growth" EXACT [] is_a: GO:0016049 ! cell growth [Term] id: GO:0051212 name: vanadium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with vanadium (V) ions." [GOC:ai] subset: gosubset_prok is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0051213 name: dioxygenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/] subset: goslim_pir subset: gosubset_prok is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0051214 name: RNA virus induced gene silencing namespace: biological_process def: "Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191] synonym: "RNA VIGS" EXACT [] synonym: "RNA virus-induced gene silencing" EXACT [] is_a: GO:0009616 ! virus induced gene silencing [Term] id: GO:0051215 name: DNA virus induced gene silencing namespace: biological_process def: "Gene silencing induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191] synonym: "DNA VIGS" EXACT [] synonym: "DNA virus-induced gene silencing" EXACT [] is_a: GO:0009616 ! virus induced gene silencing [Term] id: GO:0051216 name: cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [http://www.onelook.com] synonym: "cartilage biogenesis" EXACT [] synonym: "cartilage biosynthesis" EXACT [] synonym: "cartilage formation" EXACT [] synonym: "chondrogenesis" EXACT [] xref: Wikipedia:Chondrogenesis is_a: GO:0009888 ! tissue development relationship: part_of GO:0001501 ! skeletal system development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0051217 name: molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) namespace: biological_process def: "The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PDB:1Q16, PMID:12910261, RESID:AA0375] subset: gosubset_prok xref: RESID:AA0375 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0051218 name: tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) namespace: biological_process def: "The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PDB:1HOH, PMID:12220497, RESID:AA0376] subset: gosubset_prok xref: RESID:AA02376 is_a: GO:0042042 ! tungsten incorporation into tungsten-molybdopterin complex is_a: GO:0050844 ! peptidyl-selenocysteine modification [Term] id: GO:0051219 name: phosphoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated protein." [GOC:ai] synonym: "phosphorylated protein binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051220 name: cytoplasmic sequestering of protein namespace: biological_process def: "The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell." [GOC:ai] synonym: "cytoplasmic retention of protein" EXACT [] synonym: "cytoplasmic sequestration of protein" EXACT [] synonym: "cytoplasmic storage of protein" EXACT [] synonym: "maintenance of protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] synonym: "retention of protein in cytoplasm" EXACT [] synonym: "sequestering of protein in cytoplasm" EXACT [] synonym: "sequestration of protein in cytoplasm" EXACT [] synonym: "storage of protein in cytoplasm" EXACT [] is_a: GO:0032507 ! maintenance of protein location in cell is_a: GO:0051224 ! negative regulation of protein transport [Term] id: GO:0051221 name: tungsten incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of tungsten into a metallo-sulfur cluster." [GOC:ai] subset: gosubset_prok synonym: "tungsten incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0051222 name: positive regulation of protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of protein transport" NARROW [] synonym: "stimulation of protein transport" NARROW [] synonym: "up regulation of protein transport" EXACT [] synonym: "up-regulation of protein transport" EXACT [] synonym: "upregulation of protein transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051223 ! regulation of protein transport relationship: positively_regulates GO:0015031 ! protein transport [Term] id: GO:0051223 name: regulation of protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport is_a: GO:0070201 ! regulation of establishment of protein localization relationship: regulates GO:0015031 ! protein transport [Term] id: GO:0051224 name: negative regulation of protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of protein transport" EXACT [] synonym: "down-regulation of protein transport" EXACT [] synonym: "downregulation of protein transport" EXACT [] synonym: "inhibition of protein transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051223 ! regulation of protein transport relationship: negatively_regulates GO:0015031 ! protein transport [Term] id: GO:0051225 name: spindle assembly namespace: biological_process alt_id: GO:0051226 alt_id: GO:0051227 def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] synonym: "bipolar spindle biosynthesis" EXACT [] synonym: "bipolar spindle formation" EXACT [] synonym: "spindle biosynthesis" EXACT [] synonym: "spindle formation" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:0070925 ! organelle assembly [Term] id: GO:0051228 name: mitotic spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai] synonym: "mitotic spindle breakdown" EXACT [] synonym: "mitotic spindle catabolism" EXACT [] synonym: "mitotic spindle degradation" EXACT [] synonym: "spindle breakdown during mitosis" EXACT [] synonym: "spindle degradation during mitosis" EXACT [] synonym: "spindle disassembly during mitosis" EXACT [] is_a: GO:0007052 ! mitotic spindle organization is_a: GO:0051230 ! spindle disassembly [Term] id: GO:0051229 name: meiotic spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai] synonym: "meiotic spindle breakdown" EXACT [] synonym: "meiotic spindle catabolism" EXACT [] synonym: "meiotic spindle degradation" EXACT [] synonym: "spindle breakdown during meiosis" EXACT [] synonym: "spindle degradation during meiosis" EXACT [] synonym: "spindle disassembly during meiosis" EXACT [] is_a: GO:0000212 ! meiotic spindle organization is_a: GO:0051230 ! spindle disassembly [Term] id: GO:0051230 name: spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai] synonym: "spindle breakdown" EXACT [] synonym: "spindle catabolism" EXACT [] synonym: "spindle degradation" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:0071845 ! cellular component disassembly at cellular level [Term] id: GO:0051231 name: spindle elongation namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007051 ! spindle organization [Term] id: GO:0051232 name: meiotic spindle elongation namespace: biological_process def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai] synonym: "spindle elongation during meiosis" EXACT [] is_a: GO:0051231 ! spindle elongation relationship: part_of GO:0000212 ! meiotic spindle organization [Term] id: GO:0051233 name: spindle midzone namespace: cellular_component def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] synonym: "central spindle" EXACT [PMID:14528012] synonym: "spindle equator" EXACT [] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle [Term] id: GO:0051234 name: establishment of localization namespace: biological_process def: "The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0008150 ! biological_process relationship: part_of GO:0051179 ! localization [Term] id: GO:0051235 name: maintenance of location namespace: biological_process def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "retention" NARROW [] synonym: "sequestering" NARROW [] synonym: "storage" NARROW [] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0051179 ! localization [Term] id: GO:0051236 name: establishment of RNA localization namespace: biological_process def: "The directed movement of RNA to a specific location." [GOC:ai] synonym: "establishment of RNA localisation" EXACT [GOC:mah] synonym: "RNA positioning" EXACT [] synonym: "RNA recruitment" EXACT [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0006403 ! RNA localization [Term] id: GO:0051237 name: maintenance of RNA location namespace: biological_process def: "Any process in which RNA is maintained in a location and prevented from moving elsewhere." [GOC:ai] synonym: "maintenance of RNA localization" RELATED [GOC:dph, GOC:tb] synonym: "RNA retention" EXACT [] is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0006403 ! RNA localization [Term] id: GO:0051238 name: sequestering of metal ion namespace: biological_process def: "The process of binding or confining metal ions such that they are separated from other components of a biological system." [GOC:ai] subset: gosubset_prok synonym: "metal ion retention" EXACT [] synonym: "metal ion sequestering" EXACT [] synonym: "metal ion sequestration" EXACT [] synonym: "metal ion storage" EXACT [] synonym: "retention of metal ion" EXACT [] synonym: "sequestration of metal ion" EXACT [] synonym: "storage of metal ion" EXACT [] is_a: GO:0051235 ! maintenance of location [Term] id: GO:0051239 name: regulation of multicellular organismal process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051240 name: positive regulation of multicellular organismal process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "activation of multicellular organismal process" NARROW [] synonym: "stimulation of multicellular organismal process" NARROW [] synonym: "up regulation of multicellular organismal process" EXACT [] synonym: "up-regulation of multicellular organismal process" EXACT [] synonym: "upregulation of multicellular organismal process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process relationship: positively_regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051241 name: negative regulation of multicellular organismal process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "down regulation of multicellular organismal process" EXACT [] synonym: "down-regulation of multicellular organismal process" EXACT [] synonym: "downregulation of multicellular organismal process" EXACT [] synonym: "inhibition of multicellular organismal process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process relationship: negatively_regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051245 name: negative regulation of cellular defense response namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the cellular defense response." [GOC:ai] synonym: "down regulation of cellular defense response" EXACT [] synonym: "down-regulation of cellular defense response" EXACT [] synonym: "downregulation of cellular defense response" EXACT [] synonym: "inhibition of cellular defense response" NARROW [] synonym: "negative regulation of cellular defence response" EXACT [] is_a: GO:0010185 ! regulation of cellular defense response is_a: GO:0031348 ! negative regulation of defense response relationship: negatively_regulates GO:0006968 ! cellular defense response [Term] id: GO:0051246 name: regulation of protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] subset: gosubset_prok synonym: "regulation of protein metabolism" EXACT [] is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] subset: gosubset_prok synonym: "activation of protein metabolic process" NARROW [] synonym: "positive regulation of protein metabolism" EXACT [] synonym: "stimulation of protein metabolic process" NARROW [] synonym: "up regulation of protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process relationship: positively_regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] subset: gosubset_prok synonym: "down regulation of protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] synonym: "inhibition of protein metabolic process" NARROW [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process relationship: negatively_regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051249 name: regulation of lymphocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai] is_a: GO:0002694 ! regulation of leukocyte activation relationship: regulates GO:0046649 ! lymphocyte activation [Term] id: GO:0051250 name: negative regulation of lymphocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "down regulation of lymphocyte activation" EXACT [] synonym: "down-regulation of lymphocyte activation" EXACT [] synonym: "downregulation of lymphocyte activation" EXACT [] synonym: "inhibition of lymphocyte activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation relationship: negatively_regulates GO:0046649 ! lymphocyte activation [Term] id: GO:0051251 name: positive regulation of lymphocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "activation of lymphocyte activation" NARROW [] synonym: "stimulation of lymphocyte activation" NARROW [] synonym: "up regulation of lymphocyte activation" EXACT [] synonym: "up-regulation of lymphocyte activation" EXACT [] synonym: "upregulation of lymphocyte activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation relationship: positively_regulates GO:0046649 ! lymphocyte activation [Term] id: GO:0051252 name: regulation of RNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] subset: gosubset_prok synonym: "regulation of RNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051253 name: negative regulation of RNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] subset: gosubset_prok synonym: "down regulation of RNA metabolic process" EXACT [] synonym: "down-regulation of RNA metabolic process" EXACT [] synonym: "downregulation of RNA metabolic process" EXACT [] synonym: "inhibition of RNA metabolic process" NARROW [] synonym: "negative regulation of RNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process relationship: negatively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051254 name: positive regulation of RNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] subset: gosubset_prok synonym: "activation of RNA metabolic process" NARROW [] synonym: "positive regulation of RNA metabolism" EXACT [] synonym: "stimulation of RNA metabolic process" NARROW [] synonym: "up regulation of RNA metabolic process" EXACT [] synonym: "up-regulation of RNA metabolic process" EXACT [] synonym: "upregulation of RNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process relationship: positively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051255 name: spindle midzone assembly namespace: biological_process def: "The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] synonym: "spindle midzone biogenesis" EXACT [] synonym: "spindle midzone biosynthesis" EXACT [] synonym: "spindle midzone formation" EXACT [] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0051225 ! spindle assembly [Term] id: GO:0051256 name: spindle midzone assembly involved in mitosis namespace: biological_process def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of mitosis." [GOC:ai, GOC:expert_rg, GOC:tb] synonym: "mitotic spindle midzone assembly" RELATED [] synonym: "mitotic spindle midzone biogenesis" EXACT [] synonym: "mitotic spindle midzone biosynthesis" EXACT [] synonym: "mitotic spindle midzone formation" EXACT [] synonym: "spindle midzone biogenesis involved in mitosis" EXACT [] synonym: "spindle midzone formation involved in mitosis" EXACT [] is_a: GO:0051255 ! spindle midzone assembly relationship: part_of GO:0090307 ! spindle assembly involved in mitosis [Term] id: GO:0051257 name: spindle midzone assembly involved in meiosis namespace: biological_process def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis." [GOC:ai, GOC:expert_rg, GOC:tb] synonym: "meiotic spindle midzone assembly" RELATED [] synonym: "meiotic spindle midzone biogenesis" EXACT [] synonym: "meiotic spindle midzone biosynthesis" EXACT [] synonym: "meiotic spindle midzone formation" EXACT [] synonym: "spindle midzone biogenesis involved in meiosis" EXACT [] synonym: "spindle midzone biosynthesis involved in meiosis" EXACT [] synonym: "spindle midzone formation involved in meiosis" EXACT [] is_a: GO:0051255 ! spindle midzone assembly relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0051258 name: protein polymerization namespace: biological_process def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "protein polymer biosynthesis" EXACT [] synonym: "protein polymer biosynthetic process" EXACT [] synonym: "protein polymer formation" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0051259 name: protein oligomerization namespace: biological_process def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] subset: gosubset_prok synonym: "protein oligomer assembly" EXACT [] synonym: "protein oligomer biosynthesis" EXACT [] synonym: "protein oligomer biosynthetic process" EXACT [] synonym: "protein oligomer formation" EXACT [] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0051260 name: protein homooligomerization namespace: biological_process def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] subset: gosubset_prok synonym: "protein homooligomer assembly" EXACT [] synonym: "protein homooligomer biosynthesis" EXACT [] synonym: "protein homooligomer biosynthetic process" EXACT [] synonym: "protein homooligomer formation" EXACT [] synonym: "protein homooligomerization activity" RELATED [] is_a: GO:0051259 ! protein oligomerization [Term] id: GO:0051261 name: protein depolymerization namespace: biological_process def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "protein polymer breakdown" EXACT [] synonym: "protein polymer catabolic process" EXACT [] synonym: "protein polymer catabolism" EXACT [] synonym: "protein polymer degradation" EXACT [] is_a: GO:0043624 ! cellular protein complex disassembly [Term] id: GO:0051262 name: protein tetramerization namespace: biological_process def: "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd] subset: gosubset_prok synonym: "protein tetramer assembly" EXACT [] synonym: "protein tetramer biosynthesis" EXACT [] synonym: "protein tetramer biosynthetic process" EXACT [] synonym: "protein tetramer formation" EXACT [] is_a: GO:0051259 ! protein oligomerization [Term] id: GO:0051263 name: microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine namespace: biological_process def: "The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain." [RESID:AA0374] subset: gosubset_prok synonym: "microcin E492 anabolism by siderophore ester modification of peptidyl-serine" EXACT [] synonym: "microcin E492 formation by siderophore ester modification of peptidyl-serine" EXACT [] synonym: "microcin E492 synthesis by siderophore ester modification of peptidyl-serine" EXACT [] xref: RESID:AA0374 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0051264 name: mono-olein transacylation activity namespace: molecular_function def: "Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol." [GOC:ai, PMID:15364929] synonym: "acyl-CoA-independent mono-olein transacylation" EXACT [] synonym: "MOG transacylation" EXACT [] synonym: "mono-oleoylglycerol O-acyltransferase activity" EXACT [] synonym: "mono-oleoylglycerol transacylase activity" EXACT [] synonym: "monoolein transacylation" EXACT [] synonym: "monooleoylglycerol O-acyltransferase activity" EXACT [] synonym: "monooleoylglycerol transacylase activity" EXACT [] is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0051265 name: diolein transacylation activity namespace: molecular_function def: "Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein." [GOC:ai, PMID:15364929] synonym: "acyl-CoA-independent diolein transacylation" EXACT [] synonym: "dioleoylglycerol O-acyltransferase activity" EXACT [] synonym: "dioleoylglycerol transacylase activity" EXACT [] synonym: "DOG transacylation" EXACT [] is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0051266 name: sirohydrochlorin ferrochelatase activity namespace: molecular_function def: "Catalysis of the reaction: siroheme OK = Fe(2+) + sirohydrochlorin." [EC:4.99.1.4, RHEA:24363] subset: gosubset_prok synonym: "CysG" RELATED [EC:4.99.1.4] synonym: "Met8P" RELATED [EC:4.99.1.4] synonym: "SirB" RELATED [EC:4.99.1.4] synonym: "siroheme ferro-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.4] synonym: "siroheme synthase activity" BROAD [] synonym: "sirohydrochlorin ferro-lyase activity" EXACT [] xref: EC:4.99.1.4 xref: KEGG:R02864 xref: MetaCyc:SIROHEME-FERROCHELAT-RXN xref: RHEA:24363 is_a: GO:0004325 ! ferrochelatase activity [Term] id: GO:0051267 name: CP2 mannose-ethanolamine phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2." [PMID:14985347, PMID:15452134] synonym: "addition of ethanolamine phosphate to mannose of GPI precursor CP2" EXACT [] synonym: "CP2 ethanolamine phosphate transferase activity" EXACT [] synonym: "CP2 EtN-P transferase activity" EXACT [] synonym: "CP2 phosphoethanolamine transferase activity" EXACT [] synonym: "gpi7 activity" RELATED [] is_a: GO:0051377 ! mannose-ethanolamine phosphotransferase activity [Term] id: GO:0051268 name: alpha-keto amide reductase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic." [GOC:ai, PMID:15564669] xref: EC:1.2.-.- is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0051269 name: alpha-keto ester reductase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic." [GOC:ai, PMID:15564669] xref: EC:1.2.-.- is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0051270 name: regulation of cellular component movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] subset: gosubset_prok synonym: "regulation of cell movement" RELATED [] synonym: "regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0006928 ! cellular component movement [Term] id: GO:0051271 name: negative regulation of cellular component movement namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] subset: gosubset_prok synonym: "down regulation of cell motility" EXACT [] synonym: "down-regulation of cell motility" EXACT [] synonym: "downregulation of cell motility" EXACT [] synonym: "inhibition of cell motility" NARROW [] synonym: "negative regulation of cell movement" RELATED [] synonym: "negative regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement relationship: negatively_regulates GO:0006928 ! cellular component movement [Term] id: GO:0051272 name: positive regulation of cellular component movement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] subset: gosubset_prok synonym: "activation of cell motility" NARROW [] synonym: "positive regulation of cell movement" RELATED [] synonym: "positive regulation of cellular component motion" EXACT [GOC:mah] synonym: "stimulation of cell motility" NARROW [] synonym: "up regulation of cell motility" EXACT [] synonym: "up-regulation of cell motility" EXACT [] synonym: "upregulation of cell motility" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement relationship: positively_regulates GO:0006928 ! cellular component movement [Term] id: GO:0051273 name: beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds." [GOC:ai] subset: gosubset_prok synonym: "beta-glucan metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0051274 name: beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-glucans." [GOC:ai] subset: gosubset_prok synonym: "beta-glucan anabolism" EXACT [] synonym: "beta-glucan biosynthesis" EXACT [] synonym: "beta-glucan formation" EXACT [] synonym: "beta-glucan synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0051275 name: beta-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-glucans." [GOC:ai] subset: gosubset_prok synonym: "beta-glucan breakdown" EXACT [] synonym: "beta-glucan catabolism" EXACT [] synonym: "beta-glucan degradation" EXACT [] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0051276 name: chromosome organization namespace: biological_process alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0006996 ! organelle organization [Term] id: GO:0051278 name: fungal-type cell wall polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall." [GOC:ai, GOC:mtg_sensu] synonym: "cell wall polysaccharide anabolism" BROAD [] synonym: "cell wall polysaccharide formation" BROAD [] synonym: "cell wall polysaccharide synthesis" BROAD [] synonym: "chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process" NARROW [] is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis [Term] id: GO:0051279 name: regulation of release of sequestered calcium ion into cytosol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb] synonym: "regulation of calcium ion (Ca2+) mobilization" EXACT [] synonym: "regulation of calcium mobilization" EXACT [] synonym: "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "regulation of cytoplasmic release of stored calcium ion (Ca2+)" EXACT [] synonym: "regulation of release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "regulation of release of stored calcium ion (Ca2+)" BROAD [] synonym: "regulation of release of stored calcium ion (Ca2+) into cytoplasm" EXACT [] synonym: "regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] is_a: GO:0010522 ! regulation of calcium ion transport into cytosol relationship: regulates GO:0051209 ! release of sequestered calcium ion into cytosol [Term] id: GO:0051280 name: negative regulation of release of sequestered calcium ion into cytosol namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] synonym: "down regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "down-regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "downregulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "inhibition of release of sequestered calcium ion into cytosol" NARROW [] synonym: "negative regulation of calcium ion (Ca2+) mobilization" BROAD [] synonym: "negative regulation of calcium mobilization" BROAD [] synonym: "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of release of sequestered calcium ion into cytoplasm" BROAD [] synonym: "negative regulation of release of stored calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol relationship: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol [Term] id: GO:0051281 name: positive regulation of release of sequestered calcium ion into cytosol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] synonym: "activation of release of sequestered calcium ion into cytosol" NARROW [] synonym: "positive regulation of calcium ion (Ca2+) mobilization" BROAD [] synonym: "positive regulation of calcium mobilization" BROAD [] synonym: "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of release of sequestered calcium ion into cytoplasm" BROAD [] synonym: "positive regulation of release of stored calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] synonym: "stimulation of release of sequestered calcium ion into cytosol" NARROW [] synonym: "up regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "up-regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "upregulation of release of sequestered calcium ion into cytosol" EXACT [] is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol relationship: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol [Term] id: GO:0051282 name: regulation of sequestering of calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "regulation of calcium ion (Ca2+) retention" EXACT [] synonym: "regulation of calcium ion (Ca2+) sequestering" EXACT [] synonym: "regulation of calcium ion (Ca2+) sequestration" EXACT [] synonym: "regulation of calcium ion (Ca2+) storage" EXACT [] synonym: "regulation of retention of calcium ion (Ca2+)" EXACT [] synonym: "regulation of sequestering of calcium ion (Ca2+)" EXACT [] synonym: "regulation of sequestration of calcium ion (Ca2+)" EXACT [] synonym: "regulation of storage of calcium ion (Ca2+)" EXACT [] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process is_a: GO:2000021 ! regulation of ion homeostasis relationship: regulates GO:0051208 ! sequestering of calcium ion [Term] id: GO:0051283 name: negative regulation of sequestering of calcium ion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "down regulation of sequestering of calcium ion" EXACT [] synonym: "down-regulation of sequestering of calcium ion" EXACT [] synonym: "downregulation of sequestering of calcium ion" EXACT [] synonym: "inhibition of sequestering of calcium ion" NARROW [] synonym: "negative regulation of calcium ion (Ca2+) retention" EXACT [] synonym: "negative regulation of calcium ion (Ca2+) sequestering" EXACT [] synonym: "negative regulation of calcium ion (Ca2+) sequestration" EXACT [] synonym: "negative regulation of calcium ion (Ca2+) storage" EXACT [] synonym: "negative regulation of retention of calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of sequestering of calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of sequestration of calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of storage of calcium ion (Ca2+)" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051282 ! regulation of sequestering of calcium ion relationship: negatively_regulates GO:0051208 ! sequestering of calcium ion [Term] id: GO:0051284 name: positive regulation of sequestering of calcium ion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "activation of sequestering of calcium ion" NARROW [] synonym: "positive regulation of calcium ion (Ca2+) retention" EXACT [] synonym: "positive regulation of calcium ion (Ca2+) sequestering" EXACT [] synonym: "positive regulation of calcium ion (Ca2+) sequestration" EXACT [] synonym: "positive regulation of calcium ion (Ca2+) storage" EXACT [] synonym: "positive regulation of retention of calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of sequestering of calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of sequestration of calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of storage of calcium ion (Ca2+)" EXACT [] synonym: "stimulation of sequestering of calcium ion" NARROW [] synonym: "up regulation of sequestering of calcium ion" EXACT [] synonym: "up-regulation of sequestering of calcium ion" EXACT [] synonym: "upregulation of sequestering of calcium ion" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051282 ! regulation of sequestering of calcium ion relationship: positively_regulates GO:0051208 ! sequestering of calcium ion [Term] id: GO:0051285 name: cell cortex of cell tip namespace: cellular_component def: "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai] synonym: "cell cortex of cell end" EXACT [] is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0051286 ! cell tip [Term] id: GO:0051286 name: cell tip namespace: cellular_component def: "The region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai, GOC:mah] synonym: "cell end" EXACT [GOC:mah] is_a: GO:0044464 ! cell part [Term] id: GO:0051287 name: NAD binding namespace: molecular_function alt_id: GO:0051288 def: "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] synonym: "NAD or NADH binding" RELATED [GOC:mah] synonym: "NAD+ or NADH binding" RELATED [] synonym: "nicotinamide adenine dinucleotide binding" EXACT [] is_a: GO:0000166 ! nucleotide binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0051289 name: protein homotetramerization namespace: biological_process def: "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators] subset: gosubset_prok synonym: "protein homotetramer assembly" EXACT [] synonym: "protein homotetramer biosynthesis" EXACT [] synonym: "protein homotetramer biosynthetic process" EXACT [] synonym: "protein homotetramer formation" EXACT [] is_a: GO:0051260 ! protein homooligomerization is_a: GO:0051262 ! protein tetramerization [Term] id: GO:0051290 name: protein heterotetramerization namespace: biological_process def: "The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical." [GOC:go_curators] subset: gosubset_prok synonym: "protein heterotetramer assembly" EXACT [] synonym: "protein heterotetramer biosynthesis" EXACT [] synonym: "protein heterotetramer biosynthetic process" EXACT [] synonym: "protein heterotetramer formation" EXACT [] is_a: GO:0051262 ! protein tetramerization is_a: GO:0051291 ! protein heterooligomerization [Term] id: GO:0051291 name: protein heterooligomerization namespace: biological_process def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] subset: gosubset_prok synonym: "protein heterooligomer assembly" EXACT [] synonym: "protein heterooligomer biosynthesis" EXACT [] synonym: "protein heterooligomer biosynthetic process" EXACT [] synonym: "protein heterooligomer formation" EXACT [] is_a: GO:0051259 ! protein oligomerization [Term] id: GO:0051292 name: nuclear pore complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah] synonym: "NPC assembly" EXACT [] synonym: "nuclear pore assembly" EXACT [] synonym: "nuclear pore biogenesis" EXACT [] synonym: "nuclear pore biosynthesis" EXACT [] synonym: "nuclear pore complex biogenesis" EXACT [] synonym: "nuclear pore complex biosynthesis" EXACT [] synonym: "nuclear pore complex formation" EXACT [] synonym: "nuclear pore formation" EXACT [] is_a: GO:0006999 ! nuclear pore organization is_a: GO:0043623 ! cellular protein complex assembly is_a: GO:0046931 ! pore complex assembly [Term] id: GO:0051293 name: establishment of spindle localization namespace: biological_process def: "The directed movement of the spindle to a specific location in the cell." [GOC:ai] synonym: "establishment of spindle localisation" EXACT [GOC:mah] synonym: "spindle positioning" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0051653 ! spindle localization [Term] id: GO:0051294 name: establishment of spindle orientation namespace: biological_process def: "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai] synonym: "orienting of spindle" EXACT [] synonym: "spindle orientation" EXACT [] is_a: GO:0051293 ! establishment of spindle localization relationship: part_of GO:0030010 ! establishment of cell polarity [Term] id: GO:0051295 name: establishment of meiotic spindle localization namespace: biological_process def: "The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai] synonym: "establishment of meiotic spindle localisation" EXACT [GOC:mah] synonym: "meiotic spindle positioning" EXACT [] synonym: "spindle positioning during meiosis" RELATED [] synonym: "spindle positioning involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process is_a: GO:0051293 ! establishment of spindle localization relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051296 name: establishment of meiotic spindle orientation namespace: biological_process def: "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai] synonym: "establishment of spindle orientation during meiosis" RELATED [] synonym: "establishment of spindle orientation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "meiotic spindle orientation" EXACT [] synonym: "orienting of meiotic spindle" EXACT [] is_a: GO:0051294 ! establishment of spindle orientation is_a: GO:0051295 ! establishment of meiotic spindle localization [Term] id: GO:0051297 name: centrosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "centrosome organisation" EXACT [GOC:curators] synonym: "centrosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031023 ! microtubule organizing center organization [Term] id: GO:0051298 name: centrosome duplication namespace: biological_process def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] synonym: "centrosome replication" EXACT [] is_a: GO:0051297 ! centrosome organization relationship: part_of GO:0007098 ! centrosome cycle [Term] id: GO:0051299 name: centrosome separation namespace: biological_process def: "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] is_a: GO:0051297 ! centrosome organization relationship: part_of GO:0007098 ! centrosome cycle [Term] id: GO:0051300 name: spindle pole body organization namespace: biological_process alt_id: GO:0051426 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "SPB maturation" RELATED [GOC:vw] synonym: "SPB organization" EXACT [] synonym: "spindle pole body maturation" RELATED [GOC:vw] synonym: "spindle pole body organisation" EXACT [GOC:curators] synonym: "spindle pole body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0031023 ! microtubule organizing center organization [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis excludes nuclear division; in prokaryotes, there is little difference between cytokinesis and cell division. Note that there is no relationship between this term and 'nuclear division ; GO:0000280' because cell division can take place without nuclear division (as in prokaryotes) and vice versa (as in syncytium formation by mitosis without cytokinesis. subset: goslim_generic subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Cell_division is_a: GO:0009987 ! cellular process [Term] id: GO:0051302 name: regulation of cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0051301 ! cell division [Term] id: GO:0051303 name: establishment of chromosome localization namespace: biological_process def: "The directed movement of a chromosome to a specific location." [GOC:ai] synonym: "chromosome positioning" EXACT [] synonym: "establishment of chromosome localisation" EXACT [GOC:mah] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0050000 ! chromosome localization [Term] id: GO:0051304 name: chromosome separation namespace: biological_process def: "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with untanglement of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, PMID:20352243] synonym: "chromatid release" RELATED [GOC:lb, GOC:mah, PMID:20352243] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007059 ! chromosome segregation [Term] id: GO:0051305 name: chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes." [GOC:ai] synonym: "chromosome migration to spindle pole" EXACT [] synonym: "chromosome movement" BROAD [] synonym: "chromosome movement to spindle pole" EXACT [] is_a: GO:0051303 ! establishment of chromosome localization relationship: part_of GO:0007059 ! chromosome segregation [Term] id: GO:0051306 name: mitotic sister chromatid separation namespace: biological_process def: "The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai] synonym: "chromosome separation during mitosis" RELATED [] synonym: "mitotic chromosome separation" RELATED [] synonym: "mitotic sister chromatid resolution" EXACT [GOC:mah] synonym: "sister chromatid separation during mitosis" EXACT [] is_a: GO:0051304 ! chromosome separation relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0051307 name: meiotic chromosome separation namespace: biological_process def: "The process in which chromosomes are physically detached from each other during meiosis." [GOC:ai] synonym: "chromosome separation during meiosis" EXACT [] synonym: "meiotic chromosome resolution" EXACT [GOC:mah] is_a: GO:0051304 ! chromosome separation relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051308 name: male meiosis chromosome separation namespace: biological_process def: "The process in which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai] synonym: "chromosome separation during male meiosis" EXACT [] synonym: "male meiosis chromosome resolution" EXACT [GOC:mah] is_a: GO:0007060 ! male meiosis chromosome segregation is_a: GO:0051307 ! meiotic chromosome separation [Term] id: GO:0051309 name: female meiosis chromosome separation namespace: biological_process def: "The process in which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai] synonym: "chromosome separation during female meiosis" EXACT [] synonym: "female meiosis chromosome resolution" EXACT [GOC:mah] is_a: GO:0016321 ! female meiosis chromosome segregation is_a: GO:0051307 ! meiotic chromosome separation [Term] id: GO:0051310 name: metaphase plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ai] synonym: "chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051303 ! establishment of chromosome localization relationship: part_of GO:0007059 ! chromosome segregation [Term] id: GO:0051311 name: meiotic metaphase plate congression namespace: biological_process def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai] synonym: "metaphase plate congression during meiosis" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051310 ! metaphase plate congression relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051312 name: chromosome decondensation namespace: biological_process def: "The alteration of chromosome structure from the condensed form to a relaxed disperse form." [GOC:ai] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0051313 name: attachment of spindle microtubules to chromosome namespace: biological_process def: "The process in which spindle microtubules become physically associated with a chromosome." [GOC:ai] synonym: "microtubule and chromosome interaction" BROAD [] synonym: "spindle chromosome attachment" EXACT [] synonym: "spindle-chromosome interaction" BROAD [] is_a: GO:0034453 ! microtubule anchoring relationship: part_of GO:0007059 ! chromosome segregation [Term] id: GO:0051314 name: attachment of spindle microtubules to mitotic chromosome namespace: biological_process def: "The cell cycle process in which spindle microtubules become physically associated with a chromosome during mitosis." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0051313 ! attachment of spindle microtubules to chromosome relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0051315 name: attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation namespace: biological_process def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:dph, GOC:tb] synonym: "mitotic bipolar attachment" RELATED [GOC:vw] is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0051316 name: attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation namespace: biological_process def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation." [GOC:ai, GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED [] synonym: "attachment of spindle microtubules to kinetochore during meiotic chromosome segregation" RELATED [GOC:dph, GOC:tb] is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051317 name: attachment of spindle microtubules to meiotic chromosome namespace: biological_process def: "The cell cycle process in which spindle microtubules become physically associated with a chromosome during meiosis." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0051313 ! attachment of spindle microtubules to chromosome relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051318 name: G1 phase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:ai, GOC:dph, GOC:mah] xref: Wikipedia:G1_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051319 name: G2 phase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:ai, GOC:dph, GOC:mah] xref: Wikipedia:G2_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051320 name: S phase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place." [GOC:ai, GOC:dph, GOC:mah] synonym: "S-phase" EXACT [] xref: Wikipedia:S_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051321 name: meiotic cell cycle namespace: biological_process def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai] is_a: GO:0007049 ! cell cycle [Term] id: GO:0051322 name: anaphase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase, the third stage of chromosome segregation in the cell cycle. Canonically, sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle." [GOC:dph, GOC:mah, http://www.onelook.com] xref: NIF_Subcellular:sao21946128 xref: Wikipedia:Anaphase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051323 name: metaphase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through metaphase, the second stage of chromosome segregation in the cell cycle. Canonically, chromosomes become aligned on the equatorial plate of the cell." [GOC:dph, GOC:mah, http://www.onelook.com] xref: NIF_Subcellular:sao888950834 xref: Wikipedia:Metaphase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051324 name: prophase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through prophase, the first stage of chromosome segregation in the cell cycle. Canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:ai, GOC:dph, GOC:mah] xref: NIF_Subcellular:sao1856556831 xref: Wikipedia:Prophase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051325 name: interphase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:dph, GOC:mah, http://www.onelook.com] synonym: "karyostasis" EXACT [] synonym: "resting phase" BROAD [] xref: NIF_Subcellular:sao727427771 xref: Wikipedia:Interphase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0051326 name: telophase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through telophase, the last stage of chromosome segregation in the cell cycle. Canonically, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:dph, GOC:mah, http://www.onelook.com] xref: Wikipedia:Telophase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051327 name: M phase of meiotic cell cycle namespace: biological_process def: "M phase occurring as part of the meiotic cell cycle. M phase is the part of the cell cycle during which nuclear division takes place. A meiotic cell cycle is one in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai, GOC:dph, GOC:mah] is_a: GO:0000279 ! M phase relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051328 name: interphase of meiotic cell cycle namespace: biological_process def: "Interphase occurring as part of the meiotic cell cycle. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. A meiotic cell cycle is one in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai, GOC:dph, GOC:mah] is_a: GO:0051325 ! interphase relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051329 name: interphase of mitotic cell cycle namespace: biological_process def: "Interphase occurring as part of the mitotic cell cycle. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:ai, GOC:dph, GOC:mah] is_a: GO:0051325 ! interphase relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0051330 name: G1 phase of meiotic cell cycle namespace: biological_process def: "G1 phase occurring as part of the meiotic cell cycle. G1 phase is the interval between the completion of DNA segregation (meiosis in a meiotic cell cycle) and the beginning of DNA synthesis. A meiotic cell cycle is one in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai, GOC:dph, GOC:mah] is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051328 ! interphase of meiotic cell cycle [Term] id: GO:0051331 name: G2 phase of meiotic cell cycle namespace: biological_process def: "G2 phase occurring as part of the meiotic cell cycle. G2 phase is the interval between the completion of DNA synthesis and the beginning of DNA segregation (meiosis in a meiotic cell cycle). A meiotic cell cycle is one in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai, GOC:dph, GOC:mah] is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051328 ! interphase of meiotic cell cycle [Term] id: GO:0051332 name: S phase of meiotic cell cycle namespace: biological_process def: "S phase occurring as part of the meiotic cell cycle. S phase is the part of the cell cycle during which DNA synthesis takes place. A meiotic cell cycle is one in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai, GOC:dph, GOC:mah] synonym: "S-phase of meiotic cell cycle" EXACT [] is_a: GO:0051320 ! S phase relationship: part_of GO:0051328 ! interphase of meiotic cell cycle [Term] id: GO:0051333 name: meiotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process in which the reformation of the nuclear envelope during meiosis occurs." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0031468 ! nuclear envelope reassembly relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051334 name: meiosis I nuclear envelope reassembly namespace: biological_process def: "The reformation of the nuclear envelope during meiosis I." [GOC:ai] is_a: GO:0051333 ! meiotic nuclear envelope reassembly relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0051335 name: meiosis II nuclear envelope reassembly namespace: biological_process def: "The reformation of the nuclear envelope during meiosis II." [GOC:ai] is_a: GO:0051333 ! meiotic nuclear envelope reassembly relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0051336 name: regulation of hydrolase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [EC:3.-.-.-, GOC:ai] subset: gosubset_prok synonym: "hydrolase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0051337 name: amitosis namespace: biological_process def: "Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation." [GOC:curators, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "direct nuclear division" EXACT [] synonym: "Remak nuclear division" EXACT [] is_a: GO:0000280 ! nuclear division [Term] id: GO:0051338 name: regulation of transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-, GOC:ai] subset: gosubset_prok synonym: "transferase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0051339 name: regulation of lyase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, GOC:ai] subset: gosubset_prok synonym: "lyase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0051340 name: regulation of ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [EC:6.-.-.-, GOC:ai] subset: gosubset_prok synonym: "ligase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0051341 name: regulation of oxidoreductase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-, GOC:ai] subset: gosubset_prok synonym: "oxidoreductase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0051342 name: regulation of cyclic-nucleotide phosphodiesterase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [EC:3.1.4.17, GOC:ai, GOC:tb] synonym: "3',5' cyclic nucleotide phosphodiesterase regulator" EXACT [] synonym: "3',5'-cyclic-AMP phosphodiesterase regulator" NARROW [] synonym: "cAMP phosphodiesterase regulator" NARROW [] synonym: "phosphodiesterase regulator" RELATED [] synonym: "regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] synonym: "regulation of cAMP phosphodiesterase activity" NARROW [] synonym: "regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb] synonym: "regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0051343 name: positive regulation of cyclic-nucleotide phosphodiesterase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb] synonym: "3',5' cyclic nucleotide phosphodiesterase activator" EXACT [] synonym: "3',5'-cyclic-AMP phosphodiesterase activator" NARROW [] synonym: "activation of cyclic nucleotide phosphodiesterase activity" NARROW [] synonym: "cAMP phosphodiesterase activator" NARROW [] synonym: "phosphodiesterase activator" RELATED [] synonym: "positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] synonym: "positive regulation of cAMP phosphodiesterase activity" NARROW [] synonym: "positive regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb] synonym: "positive regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] synonym: "stimulation of cyclic nucleotide phosphodiesterase activity" NARROW [] synonym: "up regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "up-regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "upregulation of cyclic nucleotide phosphodiesterase activity" EXACT [] is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0051344 name: negative regulation of cyclic-nucleotide phosphodiesterase activity namespace: biological_process def: "Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb] synonym: "3',5' cyclic nucleotide phosphodiesterase inhibitor" EXACT [] synonym: "3',5'-cyclic-AMP phosphodiesterase inhibitor" NARROW [] synonym: "cAMP phosphodiesterase inhibitor" NARROW [] synonym: "down regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "down-regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "downregulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "inhibition of cyclic nucleotide phosphodiesterase activity" NARROW [] synonym: "negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] synonym: "negative regulation of cAMP phosphodiesterase activity" NARROW [] synonym: "negative regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb] synonym: "negative regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] synonym: "phosphodiesterase inhibitor" RELATED [] is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0051345 name: positive regulation of hydrolase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] subset: gosubset_prok synonym: "activation of hydrolase activity" NARROW [] synonym: "hydrolase activator" EXACT [] synonym: "stimulation of hydrolase activity" NARROW [] synonym: "up regulation of hydrolase activity" EXACT [] synonym: "up-regulation of hydrolase activity" EXACT [] synonym: "upregulation of hydrolase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0051346 name: negative regulation of hydrolase activity namespace: biological_process def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] subset: gosubset_prok synonym: "down regulation of hydrolase activity" EXACT [] synonym: "down-regulation of hydrolase activity" EXACT [] synonym: "downregulation of hydrolase activity" EXACT [] synonym: "hydrolase inhibitor" EXACT [] synonym: "inhibition of hydrolase activity" NARROW [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0051347 name: positive regulation of transferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] subset: gosubset_prok synonym: "activation of transferase activity" NARROW [] synonym: "stimulation of transferase activity" NARROW [] synonym: "transferase activator" EXACT [] synonym: "up regulation of transferase activity" EXACT [] synonym: "up-regulation of transferase activity" EXACT [] synonym: "upregulation of transferase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity [Term] id: GO:0051348 name: negative regulation of transferase activity namespace: biological_process def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] subset: gosubset_prok synonym: "down regulation of transferase activity" EXACT [] synonym: "down-regulation of transferase activity" EXACT [] synonym: "downregulation of transferase activity" EXACT [] synonym: "inhibition of transferase activity" NARROW [] synonym: "transferase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity [Term] id: GO:0051349 name: positive regulation of lyase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai] synonym: "activation of lyase activity" NARROW [] synonym: "lyase activator" EXACT [] synonym: "stimulation of lyase activity" NARROW [] synonym: "up regulation of lyase activity" EXACT [] synonym: "up-regulation of lyase activity" EXACT [] synonym: "upregulation of lyase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051339 ! regulation of lyase activity [Term] id: GO:0051350 name: negative regulation of lyase activity namespace: biological_process def: "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai] synonym: "down regulation of lyase activity" EXACT [] synonym: "down-regulation of lyase activity" EXACT [] synonym: "downregulation of lyase activity" EXACT [] synonym: "inhibition of lyase activity" NARROW [] synonym: "lyase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051339 ! regulation of lyase activity [Term] id: GO:0051351 name: positive regulation of ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] subset: gosubset_prok synonym: "activation of ligase activity" NARROW [] synonym: "ligase activator" EXACT [] synonym: "stimulation of ligase activity" NARROW [] synonym: "up regulation of ligase activity" EXACT [] synonym: "up-regulation of ligase activity" EXACT [] synonym: "upregulation of ligase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051340 ! regulation of ligase activity [Term] id: GO:0051352 name: negative regulation of ligase activity namespace: biological_process def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] subset: gosubset_prok synonym: "down regulation of ligase activity" EXACT [] synonym: "down-regulation of ligase activity" EXACT [] synonym: "downregulation of ligase activity" EXACT [] synonym: "inhibition of ligase activity" NARROW [] synonym: "ligase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051340 ! regulation of ligase activity [Term] id: GO:0051353 name: positive regulation of oxidoreductase activity namespace: biological_process alt_id: GO:0009391 def: "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] subset: gosubset_prok synonym: "activation of oxidoreductase activity" NARROW [] synonym: "oxidoreductase activator" EXACT [] synonym: "ribonucleotide reductase activating enzyme activity" NARROW [] synonym: "stimulation of oxidoreductase activity" NARROW [] synonym: "up regulation of oxidoreductase activity" EXACT [] synonym: "up-regulation of oxidoreductase activity" EXACT [] synonym: "upregulation of oxidoreductase activity" EXACT [] xref: EC:1.97.1.- is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051341 ! regulation of oxidoreductase activity [Term] id: GO:0051354 name: negative regulation of oxidoreductase activity namespace: biological_process def: "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] subset: gosubset_prok synonym: "down regulation of oxidoreductase activity" EXACT [] synonym: "down-regulation of oxidoreductase activity" EXACT [] synonym: "downregulation of oxidoreductase activity" EXACT [] synonym: "inhibition of oxidoreductase activity" NARROW [] synonym: "oxidoreductase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051341 ! regulation of oxidoreductase activity [Term] id: GO:0051355 name: proprioception involved in equilibrioception namespace: biological_process def: "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] synonym: "equilibrioception by proprioception" EXACT [] synonym: "perception of orientation with respect to gravity by proprioception" EXACT [] synonym: "proprioception during equilibrioception" RELATED [GOC:dph, GOC:tb] is_a: GO:0019230 ! proprioception relationship: part_of GO:0050957 ! equilibrioception [Term] id: GO:0051356 name: visual perception involved in equilibrioception namespace: biological_process def: "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] synonym: "equilibrioception by visual perception" NARROW [] synonym: "perception of orientation with respect to gravity by visual perception" EXACT [] synonym: "visual perception during equilibrioception" RELATED [GOC:dph, GOC:tb] is_a: GO:0007601 ! visual perception relationship: part_of GO:0050957 ! equilibrioception [Term] id: GO:0051357 name: peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one namespace: biological_process def: "The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10852900, PMID:11259412, PMID:15491166, RESID:AA0377] comment: Note that this predicted modification is now thought not to exist. See the biological process term 'peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine ; GO:0051359'. synonym: "biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT [] xref: RESID:AA0377 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018206 ! peptidyl-methionine modification is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051358 name: peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine namespace: biological_process def: "The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus." [PMID:11682051, RESID:AA0378] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT [] xref: RESID:AA0378 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051359 name: peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine namespace: biological_process def: "The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor." [PDB:1UIS, PDB:1XQM, PMID:10852900, PMID:12185250, PMID:12909624, PMID:15542608, RESID:AA0379] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT [] xref: RESID:AA0379 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018206 ! peptidyl-methionine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051360 name: peptide cross-linking via L-asparagine 5-imidazolinone glycine namespace: biological_process def: "The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0380] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT [] xref: RESID:AA0380 is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051361 name: peptide cross-linking via L-lysine 5-imidazolinone glycine namespace: biological_process def: "The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0381] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT [] xref: RESID:AA0381 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051362 name: peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine namespace: biological_process def: "The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species." [PDB:1XAE, PMID:10504696, PMID:15628861, RESID:AA0382] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT [] xref: RESID:AA0382 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051363 name: peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein namespace: biological_process def: "The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [PMID:8163519, PMID:9086265, RESID:AA0383] comment: Note that this modification may be unique to the species Finegoldia (Peptostreptococcus) magnus. subset: gosubset_prok xref: RESID:AA0383 is_a: GO:0018104 ! peptidoglycan-protein cross-linking is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0051364 name: N-terminal peptidyl-proline N-formylation namespace: biological_process def: "The formylation of the N-terminal proline of proteins to form the derivative N-formylproline." [PMID:12051774, PMID:5464655, RESID:AA0384] xref: RESID:AA0384 is_a: GO:0018004 ! N-terminal protein formylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0051365 name: cellular response to potassium ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions." [GOC:sm] synonym: "cellular response to K+ ion deprivation" EXACT [] synonym: "cellular response to K+ ion starvation" EXACT [] synonym: "cellular response to potassium ion deprivation" EXACT [] synonym: "cellular response to potassium starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0051366 name: protein decanoylation namespace: biological_process def: "The modification of a protein amino acid by formation of an ester or amide with decanoic acid." [GOC:jsg] synonym: "protein amino acid decanoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0051367 name: peptidyl-serine decanoylation namespace: biological_process def: "The decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin." [GOC:jsg, PMID:12630926, RESID:AA0385] xref: RESID:AA0385 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0051366 ! protein decanoylation [Term] id: GO:0051368 name: peptidyl-threonine octanoylation namespace: biological_process def: "The octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387] xref: RESID:AA0386 is_a: GO:0018190 ! protein octanoylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0051369 name: peptidyl-threonine decanoylation namespace: biological_process def: "The decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387] xref: RESID:AA0387 is_a: GO:0018210 ! peptidyl-threonine modification is_a: GO:0051366 ! protein decanoylation [Term] id: GO:0051370 name: ZASP binding namespace: molecular_function def: "Interacting selectively and non-covalently with Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain." [PMID:10427098, PMID:11699871] synonym: "Z-band alternatively spliced PDZ-motif protein binding" EXACT [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0051371 name: muscle alpha-actinin binding namespace: molecular_function def: "Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165] synonym: "alpha-actinin 2 binding" NARROW [] synonym: "alpha-actinin 3 binding" NARROW [] is_a: GO:0051393 ! alpha-actinin binding [Term] id: GO:0051372 name: nonmuscle alpha-actinin binding namespace: molecular_function def: "Interacting selectively and non-covalently with nonmuscle isoforms of actinin. Nonmuscle alpha-actinin is found at the leading edge of motile cells, cell adhesion sites, focal contacts and along actin stress fibers in migrating cells." [PMID:15014165] synonym: "alpha-actinin 1 binding" NARROW [] synonym: "alpha-actinin 4 binding" EXACT [] is_a: GO:0051393 ! alpha-actinin binding [Term] id: GO:0051373 name: FATZ binding namespace: molecular_function def: "Interacting selectively and non-covalently with a family of FATZ proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871] synonym: "calsarcin binding" EXACT [] synonym: "filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle" EXACT [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0051374 name: FATZ 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with FATZ 1, a protein of FATZ family that is highly expressed in skeletal muscle fast fiber." [PMID:10984498, PMID:11699871] synonym: "calsarcin 2 binding" EXACT [] is_a: GO:0051373 ! FATZ binding [Term] id: GO:0051375 name: FATZ 2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with FATZ 2, a protein of the FATZ family that is highly expressed in skeletal muscle fiber fast IIa and slow I and in cardiac muscle." [PMID:10984498, PMID:11699871] synonym: "calsarcin 1 binding" EXACT [] is_a: GO:0051373 ! FATZ binding [Term] id: GO:0051376 name: FATZ 3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with FATZ 3, a protein of the FATZ family that is highly expressed in skeletal muscle fast fiber." [PMID:10984498, PMID:11699871] synonym: "calsarcin 3 binding" EXACT [] is_a: GO:0051373 ! FATZ binding [Term] id: GO:0051377 name: mannose-ethanolamine phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136] synonym: "addition of ethanolamine phosphate to mannose of GPI precursor" EXACT [] synonym: "ethanolamine phosphate transferase activity" BROAD [] synonym: "EtN-P transferase activity" EXACT [] synonym: "phosphoethanolamine transferase activity" BROAD [] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0051378 name: serotonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai] synonym: "5-hydroxytryptamine binding" EXACT [] is_a: GO:0043176 ! amine binding [Term] id: GO:0051379 name: epinephrine binding namespace: molecular_function def: "Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] synonym: "adrenaline binding" EXACT [] is_a: GO:0043176 ! amine binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0051380 name: norepinephrine binding namespace: molecular_function def: "Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "noradrenaline binding" EXACT [] is_a: GO:0043176 ! amine binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0051381 name: histamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0043176 ! amine binding [Term] id: GO:0051382 name: kinetochore assembly namespace: biological_process alt_id: GO:0000069 def: "The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai] synonym: "centromere and kinetochore complex maturation" NARROW [] synonym: "centromere/kinetochore complex maturation" NARROW [] synonym: "chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "kinetochore biogenesis" EXACT [] synonym: "kinetochore biosynthesis" EXACT [] synonym: "kinetochore formation" RELATED [] is_a: GO:0043623 ! cellular protein complex assembly is_a: GO:0051383 ! kinetochore organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0034508 ! centromere complex assembly [Term] id: GO:0051383 name: kinetochore organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "kinetochore organisation" EXACT [GOC:curators] synonym: "kinetochore organization and biogenesis" RELATED [GOC:mah] is_a: GO:0034621 ! cellular macromolecular complex subunit organization is_a: GO:0051276 ! chromosome organization [Term] id: GO:0051384 name: response to glucocorticoid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai, PMID:9884123] is_a: GO:0031960 ! response to corticosteroid stimulus [Term] id: GO:0051385 name: response to mineralocorticoid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:ai, PMID:9884123] is_a: GO:0031960 ! response to corticosteroid stimulus [Term] id: GO:0051386 name: regulation of nerve growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway." [GOC:ai] synonym: "regulation of nerve growth factor receptor signalling pathway" EXACT [] synonym: "regulation of NGF receptor signaling pathway" EXACT [] synonym: "regulation of NGF receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0048011 ! nerve growth factor receptor signaling pathway [Term] id: GO:0051387 name: negative regulation of nerve growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway." [GOC:ai] synonym: "down regulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of nerve growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of nerve growth factor receptor signalling pathway" EXACT [] synonym: "negative regulation of NGF receptor signaling pathway" EXACT [] synonym: "negative regulation of NGF receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0051386 ! regulation of nerve growth factor receptor signaling pathway relationship: negatively_regulates GO:0048011 ! nerve growth factor receptor signaling pathway [Term] id: GO:0051388 name: positive regulation of nerve growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway." [GOC:ai] synonym: "activation of nerve growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of nerve growth factor receptor signalling pathway" EXACT [] synonym: "positive regulation of NGF receptor signaling pathway" EXACT [] synonym: "positive regulation of NGF receptor signalling pathway" EXACT [] synonym: "stimulation of nerve growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of nerve growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0051386 ! regulation of nerve growth factor receptor signaling pathway relationship: positively_regulates GO:0048011 ! nerve growth factor receptor signaling pathway [Term] id: GO:0051389 name: inactivation of MAPKK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase kinase." [GOC:ai] synonym: "inactivation of MAP kinase kinase activity" EXACT [] synonym: "termination of MAP kinase kinase activity" EXACT [] synonym: "termination of MAPKK activity" EXACT [] is_a: GO:0006469 ! negative regulation of protein kinase activity relationship: part_of GO:0043409 ! negative regulation of MAPKKK cascade [Term] id: GO:0051390 name: inactivation of MAPKKK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase kinase kinase." [GOC:ai] synonym: "inactivation of MAP kinase kinase kinase activity" EXACT [] synonym: "termination of MAP kinase kinase kinase activity" EXACT [] synonym: "termination of MAPKKK activity" EXACT [] is_a: GO:0006469 ! negative regulation of protein kinase activity relationship: part_of GO:0043409 ! negative regulation of MAPKKK cascade [Term] id: GO:0051391 name: tRNA acetylation namespace: biological_process def: "The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0051392 name: tRNA N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA." [PMID:15037780] synonym: "tRNA cytidine N-acetyltransferase activity" EXACT [] is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0051393 name: alpha-actinin binding namespace: molecular_function def: "Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165] is_a: GO:0042805 ! actinin binding [Term] id: GO:0051394 name: regulation of nerve growth factor receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor receptor." [GOC:ai] synonym: "regulation of NGF receptor activity" EXACT [] is_a: GO:0010469 ! regulation of receptor activity is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051386 ! regulation of nerve growth factor receptor signaling pathway [Term] id: GO:0051395 name: negative regulation of nerve growth factor receptor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor receptor." [GOC:ai] synonym: "down regulation of nerve growth factor receptor activity" EXACT [] synonym: "down-regulation of nerve growth factor receptor activity" EXACT [] synonym: "downregulation of nerve growth factor receptor activity" EXACT [] synonym: "inhibition of nerve growth factor receptor activity" NARROW [] synonym: "negative regulation of NGF receptor activity" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:0051394 ! regulation of nerve growth factor receptor activity is_a: GO:2000272 ! negative regulation of receptor activity [Term] id: GO:0051396 name: positive regulation of nerve growth factor receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor receptor." [GOC:ai] synonym: "activation of nerve growth factor receptor activity" NARROW [] synonym: "positive regulation of NGF receptor activity" EXACT [] synonym: "stimulation of nerve growth factor receptor activity" NARROW [] synonym: "up regulation of nerve growth factor receptor activity" EXACT [] synonym: "up-regulation of nerve growth factor receptor activity" EXACT [] synonym: "upregulation of nerve growth factor receptor activity" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:0051394 ! regulation of nerve growth factor receptor activity is_a: GO:2000273 ! positive regulation of receptor activity [Term] id: GO:0051397 name: N-terminal basic amino acid aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0051398 name: N-terminal lysine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] comment: This term was made obsolete because it represents a gene product. synonym: "lysine aminopeptidase activity" BROAD [] synonym: "lysyl aminopeptidase activity" BROAD [] is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0051399 name: N-terminal arginine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] comment: This term was made obsolete because it represents a gene product. synonym: "arginine aminopeptidase activity" BROAD [] synonym: "argininyl aminopeptidase activity" BROAD [] is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0051400 name: BH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] synonym: "Bcl-2 homology domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0051401 name: CH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the calponin homology domain of a protein, a domain of 100 residues that occurs in signaling and cytoskeletal proteins." [PMID:11911887, Prosite:PDOC50021] synonym: "calponin homology domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0051402 name: neuron apoptosis namespace: biological_process def: "The process of apoptosis in neurons, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [MeSH:A.08.663] synonym: "apoptosis of neuronal cells" EXACT [] synonym: "apoptosis of neurons" EXACT [] synonym: "neuron programmed cell death by apoptosis" EXACT [] synonym: "neuronal cell apoptosis" EXACT [] synonym: "neuronal cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neuronal cells by apoptosis" EXACT [] synonym: "programmed cell death of neurons by apoptosis" EXACT [] synonym: "programmed cell death, neuronal cells" EXACT [] synonym: "programmed cell death, neurons" EXACT [] is_a: GO:0006915 ! apoptosis is_a: GO:0070997 ! neuron death [Term] id: GO:0051403 name: stress-activated MAPK cascade namespace: biological_process def: "A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270] synonym: "MAPK11 cascade" NARROW [GOC:add] synonym: "MAPK12 cascade" NARROW [GOC:add] synonym: "MAPK13 cascade" NARROW [GOC:add] synonym: "MAPK14 cascade" NARROW [GOC:add] synonym: "p38 cascade" NARROW [GOC:add] synonym: "p38 MAPK signaling" EXACT [] synonym: "p38 MAPK signalling" EXACT [] synonym: "SAPK cascade" BROAD [GOC:add] synonym: "stress-activated MAPK signaling pathway" EXACT [] synonym: "stress-activated MAPK signalling pathway" EXACT [] synonym: "stress-activated MAPKKK cascade" EXACT [] synonym: "stress-activated MAPKKK signaling pathway" EXACT [] synonym: "stress-activated MAPKKK signalling pathway" EXACT [] xref: Reactome:1253141 "MAP kinase activation in TLR cascade" xref: Reactome:1280075 "MAP kinase activation in TLR cascade" xref: Reactome:1298956 "MAP kinase activation in TLR cascade" xref: Reactome:1326646 "MAP kinase activation in TLR cascade" xref: Reactome:1352758 "MAP kinase activation in TLR cascade" xref: Reactome:1372969 "MAP kinase activation in TLR cascade" xref: Reactome:1392985 "MAP kinase activation in TLR cascade" xref: Reactome:1417465 "MAP kinase activation in TLR cascade" xref: Reactome:1450558 "MAP kinase activation in TLR cascade" xref: Reactome:1471064 "MAP kinase activation in TLR cascade" xref: Reactome:1483080 "MAP kinase activation in TLR cascade" xref: Reactome:1496955 "MAP kinase activation in TLR cascade" xref: Reactome:1514342 "MAP kinase activation in TLR cascade" xref: Reactome:1521215 "MAP kinase activation in TLR cascade" xref: Reactome:1526803 "MAP kinase activation in TLR cascade" xref: Reactome:1532529 "MAP kinase activation in TLR cascade" xref: Reactome:450294 "MAP kinase activation in TLR cascade" is_a: GO:0000165 ! MAPKKK cascade is_a: GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0051404 name: clostripain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds." [EC:3.4.22.8] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8] synonym: "clostridiopeptidase B activity" EXACT [] synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8] xref: EC:3.4.22.8 is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0051405 name: microbial collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." [EC:3.4.24.3] comment: This term was made obsolete because it represents a gene product. synonym: "Achromobacter iophagus collagenase" RELATED [EC:3.4.24.3] synonym: "aspergillopeptidase C" RELATED [EC:3.4.24.3] synonym: "azocollase activity" EXACT [EC:3.4.24.3] synonym: "clostridiopeptidase A activity" EXACT [] synonym: "clostridiopeptidase I" RELATED [EC:3.4.24.3] synonym: "clostridiopeptidase II" RELATED [EC:3.4.24.3] synonym: "Clostridium histolyticum collagenase activity" NARROW [EC:3.4.24.3] synonym: "Clostridium histolyticum proteinase A" RELATED [EC:3.4.24.3] synonym: "collagen peptidase activity" EXACT [EC:3.4.24.3] synonym: "collagen protease activity" EXACT [EC:3.4.24.3] synonym: "collagenase 1 activity" EXACT [] synonym: "collagenase A activity" EXACT [] synonym: "collagenase I activity" EXACT [EC:3.4.24.3] synonym: "collagenase MMP-1" RELATED [EC:3.4.24.3] synonym: "kollaza" RELATED [EC:3.4.24.3] synonym: "matirx metalloproteinase-18" RELATED [EC:3.4.24.3] synonym: "matrix metalloproteinase-1" RELATED [EC:3.4.24.3] synonym: "matrix metalloproteinase-8" RELATED [EC:3.4.24.3] synonym: "metallocollagenase activity" EXACT [EC:3.4.24.3] synonym: "metalloproteinase-1" RELATED [EC:3.4.24.3] synonym: "nucleolysin" RELATED [EC:3.4.24.3] synonym: "soycollagestin" RELATED [EC:3.4.24.3] xref: EC:3.4.24.3 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0051406 name: beta-actinin binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-actinin, a heterodimeric actin-binding protein which caps the barbed end of actin filaments and nucleates actin polymerization in a calcium-independent manner. In myofibrils it is localized in the Z-lines." [PMID:11699871, PMID:2341404, PMID:9742448] synonym: "capZ binding" EXACT [] is_a: GO:0042805 ! actinin binding [Term] id: GO:0051407 name: glycerone phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)." [GOC:ai] synonym: "dihydroxyacetone-phosphate:inorganic phosphate antiporter activity" EXACT [] is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity [Term] id: GO:0051408 name: glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)." [GOC:ai] is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity [Term] id: GO:0051409 name: response to nitrosative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [PMID:15925705] is_a: GO:0006950 ! response to stress [Term] id: GO:0051410 name: detoxification of nitrogen compound namespace: biological_process def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai] synonym: "detoxification of nitrogenous compound" EXACT [] synonym: "nitric oxide (NO) detoxification" NARROW [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0009636 ! response to toxin is_a: GO:0051409 ! response to nitrosative stress [Term] id: GO:0051411 name: ALP binding namespace: molecular_function def: "Interacting selectively and non-covalently wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band." [PMID:11699871] synonym: "actinin-associated LIM protein binding" EXACT [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0051412 name: response to corticosterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [PMID:15240347] is_a: GO:0051384 ! response to glucocorticoid stimulus is_a: GO:0051385 ! response to mineralocorticoid stimulus [Term] id: GO:0051413 name: response to cortisone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:11276391] is_a: GO:0051384 ! response to glucocorticoid stimulus [Term] id: GO:0051414 name: response to cortisol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:11276391] synonym: "response to hydrocortisone stimulus" EXACT [] is_a: GO:0051384 ! response to glucocorticoid stimulus [Term] id: GO:0051415 name: interphase microtubule nucleation by interphase microtubule organizing center namespace: biological_process def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai] synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT [] synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT [] synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT [] synonym: "microtubule nucleation during interphase by IMTOC" EXACT [] synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT [] is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051416 name: myotilin binding namespace: molecular_function def: "Interacting selectively and non-covalently with myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C." [PMID:11699871, PMID:15752755] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0051417 name: microtubule nucleation by spindle pole body namespace: biological_process def: "The 'de novo' formation of a microtubule, mediated by the spindle pole body." [GOC:ai] synonym: "microtubule nucleation by SPB" EXACT [] synonym: "SPB-mediated microtubule nucleation" EXACT [] synonym: "spindle pole body-mediated microtubule nucleation" EXACT [] is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center [Term] id: GO:0051418 name: microtubule nucleation by microtubule organizing center namespace: biological_process def: "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center." [GOC:ai] synonym: "microtubule nucleation by microtubule organising centre" EXACT [] synonym: "microtubule nucleation by MTOC" EXACT [] synonym: "microtubule organizing center-mediated microtubule nucleation" EXACT [] synonym: "MTOC-mediated microtubule nucleation" EXACT [] is_a: GO:0007020 ! microtubule nucleation [Term] id: GO:0051419 name: nebulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone." [PMID:11699871] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0051420 name: nebulette binding namespace: molecular_function def: "Interacting selectively and non-covalently with nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin." [PMID:11699871] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0051421 name: regulation of endo-1,4-beta-xylanase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] synonym: "endo-1,4-beta-xylanase regulator" RELATED [] synonym: "xylanase regulator" RELATED [] is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0051422 name: negative regulation of endo-1,4-beta-xylanase activity namespace: biological_process def: "Any process that stops or reduces the rate of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] synonym: "down regulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "down-regulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "downregulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "endo-1,4-beta-xylanase inhibitor" RELATED [] synonym: "inhibition of endo-1,4-beta-xylanase activity" NARROW [] synonym: "xylanase inhibitor" RELATED [] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity [Term] id: GO:0051423 name: positive regulation of endo-1,4-beta-xylanase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] synonym: "activation of endo-1,4-beta-xylanase activity" NARROW [] synonym: "endo-1,4-beta-xylanase activator" RELATED [] synonym: "stimulation of endo-1,4-beta-xylanase activity" NARROW [] synonym: "up regulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "up-regulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "upregulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "xylanase activator" RELATED [] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity [Term] id: GO:0051424 name: corticotropin-releasing hormone binding namespace: molecular_function alt_id: GO:0017047 def: "Interacting selectively and non-covalently with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [http://www.onelook.com] synonym: "corticoliberin binding" EXACT [] synonym: "corticotropin-releasing factor binding" EXACT [] synonym: "CRF binding" EXACT [GOC:bf] synonym: "CRH binding" EXACT [] is_a: GO:0017046 ! peptide hormone binding [Term] id: GO:0051425 name: PTB domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein." [Pfam:PF02174.5, PMID:15924411] synonym: "phosphotyrosine-interacting domain binding" EXACT [] synonym: "PID binding" BROAD [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0051427 name: hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor for hormones." [GOC:ai] is_a: GO:0005102 ! receptor binding [Term] id: GO:0051428 name: peptide hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor for peptide hormones." [GOC:ai] synonym: "polypeptide hormone receptor binding" EXACT [] is_a: GO:0051427 ! hormone receptor binding [Term] id: GO:0051429 name: corticotropin-releasing hormone receptor binding namespace: molecular_function alt_id: GO:0031742 def: "Interacting selectively and non-covalently with a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [GOC:ai] synonym: "corticotropin releasing factor receptor binding" EXACT [] synonym: "corticotropin releasing factor receptor ligand" NARROW [] synonym: "corticotropin-releasing factor receptor binding" EXACT [GOC:bf] synonym: "CRF receptor binding" EXACT [GOC:bf] synonym: "CRH receptor binding" EXACT [GOC:bf] synonym: "CRHR binding" EXACT [GOC:bf] is_a: GO:0051428 ! peptide hormone receptor binding is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0051430 name: corticotropin-releasing hormone receptor 1 binding namespace: molecular_function alt_id: GO:0031743 def: "Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857] synonym: "CRHR1 binding" EXACT [] synonym: "type 1 corticotropin releasing factor receptor binding" EXACT [] synonym: "type 1 corticotropin releasing factor receptor ligand" NARROW [] synonym: "type 1 corticotropin-releasing factor receptor binding" EXACT [GOC:bf] is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding [Term] id: GO:0051431 name: corticotropin-releasing hormone receptor 2 binding namespace: molecular_function alt_id: GO:0031744 def: "Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery." [PMID:15134857] synonym: "CRHR2 binding" EXACT [] synonym: "type 2 corticotropin releasing factor receptor binding" EXACT [] synonym: "type 2 corticotropin releasing factor receptor ligand" NARROW [] synonym: "type 2 corticotropin-releasing factor receptor binding" EXACT [GOC:bf] is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding [Term] id: GO:0051432 name: BH1 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the BH1 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01080] is_a: GO:0051400 ! BH domain binding [Term] id: GO:0051433 name: BH2 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the BH2 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01258] is_a: GO:0051400 ! BH domain binding [Term] id: GO:0051434 name: BH3 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] is_a: GO:0051400 ! BH domain binding is_a: GO:0070513 ! death domain binding [Term] id: GO:0051435 name: BH4 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the BH4 domain of a protein of the Bcl-2 family. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein." [InterPro:IPR003093, PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01260, Prosite:PS50063] is_a: GO:0051400 ! BH domain binding [Term] id: GO:0051436 name: negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai, GOC:tb] synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW [] synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW [] synonym: "APC inhibition during mitotic cell cycle" NARROW [] synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "mitotic anaphase promoting complex inhibition" NARROW [] synonym: "mitotic anaphase promoting complex inhibitor" NARROW [] synonym: "mitotic anaphase-promoting complex inhibition" NARROW [] synonym: "mitotic anaphase-promoting complex inhibitor" NARROW [] synonym: "mitotic APC inhibition" NARROW [] synonym: "mitotic APC inhibitor" NARROW [] synonym: "mitotic SCF complex inhibitor" NARROW [] synonym: "mitotic ubiquitin ligase inhibitor" NARROW [] synonym: "negative regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] synonym: "negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] xref: Reactome:1235410 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1235422 "Association of Emi1 with Cdh1" xref: Reactome:1235462 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1235506 "Association of Emi1 with Cdc20" xref: Reactome:1235509 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: Reactome:1253270 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1253391 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1262733 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1262752 "Association of Emi1 with Cdh1" xref: Reactome:1262789 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1262830 "Association of Emi1 with Cdc20" xref: Reactome:1262831 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: Reactome:1280205 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1280330 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1287422 "Association of Emi1 with Cdh1" xref: Reactome:1287462 "Association of Emi1 with Cdc20" xref: Reactome:1299075 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1309005 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1309020 "Association of Emi1 with Cdh1" xref: Reactome:1309057 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1309097 "Association of Emi1 with Cdc20" xref: Reactome:1309100 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: Reactome:1326782 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1326908 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1336079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1336094 "Association of Emi1 with Cdh1" xref: Reactome:1336131 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1336172 "Association of Emi1 with Cdc20" xref: Reactome:1336175 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: Reactome:1352886 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1352999 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1360129 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1360141 "Association of Emi1 with Cdh1" xref: Reactome:1360167 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1360208 "Association of Emi1 with Cdc20" xref: Reactome:1373092 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1373195 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1380925 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1380937 "Association of Emi1 with Cdh1" xref: Reactome:1380962 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1381011 "Association of Emi1 with Cdc20" xref: Reactome:1393107 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1393209 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1402022 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1402040 "Association of Emi1 with Cdh1" xref: Reactome:1402077 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1402118 "Association of Emi1 with Cdc20" xref: Reactome:1402121 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: Reactome:141405 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1417593 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1417705 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1430037 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1430060 "Association of Emi1 with Cdh1" xref: Reactome:1430108 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1430150 "Association of Emi1 with Cdc20" xref: Reactome:1430153 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: Reactome:1450684 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1450804 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1458783 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1458818 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1458897 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: Reactome:1471148 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1471215 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1476512 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: Reactome:1483150 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:1489965 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1489985 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1496897 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1505139 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:1505148 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:1514290 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:1521102 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components" xref: Reactome:174079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:174084 "Autodegradation of Cdh1 by Cdh1:APC/C" xref: Reactome:174097 "Association of Emi1 with Cdh1" xref: Reactome:174139 "Dissociation of phospho-Cdh1 from the APC/C complex" xref: Reactome:174235 "Association of Emi1 with Cdc20" xref: Reactome:174251 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" is_a: GO:0051439 ! regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle is_a: GO:0051444 ! negative regulation of ubiquitin-protein ligase activity [Term] id: GO:0051437 name: positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle namespace: biological_process def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai, GOC:tb] synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "mitotic SCF complex activator" NARROW [] synonym: "mitotic ubiquitin ligase activator" NARROW [] synonym: "positive regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] synonym: "positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] xref: Reactome:1235508 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1" xref: Reactome:1253395 "Phosphorylation of the APC/C" xref: Reactome:1253401 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:1280334 "Phosphorylation of the APC/C" xref: Reactome:1280340 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:1309099 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1" xref: Reactome:1326912 "Phosphorylation of the APC/C" xref: Reactome:1326918 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:1336174 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1" xref: Reactome:1353003 "Phosphorylation of the APC/C" xref: Reactome:1353009 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:1360210 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1" xref: Reactome:1373199 "Phosphorylation of the APC/C" xref: Reactome:1373204 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:1381013 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1" xref: Reactome:1393213 "Phosphorylation of the APC/C" xref: Reactome:1393218 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:1402120 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1" xref: Reactome:1417709 "Phosphorylation of the APC/C" xref: Reactome:1417715 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:1430152 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1" xref: Reactome:1450809 "Phosphorylation of the APC/C" xref: Reactome:1458896 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1" xref: Reactome:1471219 "Phosphorylation of the APC/C" xref: Reactome:1471224 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:1483213 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:1532641 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:174113 "SCF-beta-TrCP mediated degradation of Emi1" xref: Reactome:174238 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1" xref: Reactome:176412 "Phosphorylation of the APC/C" is_a: GO:0051439 ! regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle is_a: GO:0051443 ! positive regulation of ubiquitin-protein ligase activity [Term] id: GO:0051438 name: regulation of ubiquitin-protein ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, GOC:ai, GOC:tb] synonym: "anaphase-promoting complex regulator" NARROW [] synonym: "APC regulator" NARROW [] synonym: "regulation of ubiquitin ligase activity" EXACT [GOC:tb] synonym: "SCF complex regulator" NARROW [] synonym: "ubiquitin ligase regulator" RELATED [] synonym: "ubiquitin-protein ligase regulator" RELATED [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:0051340 ! regulation of ligase activity [Term] id: GO:0051439 name: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai] synonym: "mitotic anaphase-promoting complex regulator" NARROW [] synonym: "mitotic APC regulator" NARROW [] synonym: "mitotic SCF complex regulator" NARROW [] synonym: "mitotic ubiquitin ligase regulator" RELATED [] synonym: "mitotic ubiquitin-protein ligase regulator" RELATED [] synonym: "regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] synonym: "regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] xref: Reactome:1253271 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1253392 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1280207 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1280331 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1299077 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1299179 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1326783 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1326909 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1352887 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1353000 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1373093 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1373196 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1393108 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1393210 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1417594 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1417706 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1450685 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1450805 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1471149 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1471216 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1483152 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1496900 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1496901 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1514293 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1514294 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1521103 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:1526905 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1532638 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:1532642 "Regulation of APC/C activators between G1/S and early anaphase" xref: Reactome:176407 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" xref: Reactome:176408 "Regulation of APC/C activators between G1/S and early anaphase" is_a: GO:0022402 ! cell cycle process is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0051440 name: regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] synonym: "meiotic anaphase-promoting complex regulator" NARROW [] synonym: "meiotic APC regulator" NARROW [] synonym: "meiotic SCF complex regulator" NARROW [] synonym: "meiotic ubiquitin ligase regulator" RELATED [] synonym: "meiotic ubiquitin-protein ligase regulator" RELATED [] synonym: "regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb] synonym: "regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051441 name: positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle namespace: biological_process def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] synonym: "meiotic SCF complex activator" NARROW [] synonym: "meiotic ubiquitin ligase activator" NARROW [] synonym: "positive regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb] synonym: "positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] is_a: GO:0051440 ! regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle is_a: GO:0051443 ! positive regulation of ubiquitin-protein ligase activity [Term] id: GO:0051442 name: negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW [] synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW [] synonym: "APC inhibition during meiotic cell cycle" NARROW [] synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW [] synonym: "meiotic anaphase promoting complex inhibition" NARROW [] synonym: "meiotic anaphase promoting complex inhibitor" NARROW [] synonym: "meiotic anaphase-promoting complex inhibition" NARROW [] synonym: "meiotic anaphase-promoting complex inhibitor" NARROW [] synonym: "meiotic APC inhibition" NARROW [] synonym: "meiotic APC inhibitor" NARROW [] synonym: "meiotic SCF complex inhibitor" NARROW [] synonym: "meiotic ubiquitin ligase inhibitor" NARROW [] synonym: "negative regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb] is_a: GO:0051440 ! regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle is_a: GO:0051444 ! negative regulation of ubiquitin-protein ligase activity [Term] id: GO:0051443 name: positive regulation of ubiquitin-protein ligase activity namespace: biological_process def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, GOC:ai, GOC:tb] synonym: "activation of ubiquitin ligase activity" NARROW [] synonym: "anaphase promoting complex activator" NARROW [] synonym: "anaphase-promoting complex activator" NARROW [] synonym: "APC activation" NARROW [] synonym: "APC activator" NARROW [] synonym: "positive regulation of ubiquitin ligase activity" EXACT [GOC:tb] synonym: "SCF complex activator" NARROW [] synonym: "stimulation of ubiquitin ligase activity" NARROW [] synonym: "ubiquitin ligase activator" NARROW [] synonym: "up regulation of ubiquitin ligase activity" EXACT [] synonym: "up-regulation of ubiquitin ligase activity" EXACT [] synonym: "upregulation of ubiquitin ligase activity" EXACT [] is_a: GO:0031398 ! positive regulation of protein ubiquitination is_a: GO:0051351 ! positive regulation of ligase activity is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity [Term] id: GO:0051444 name: negative regulation of ubiquitin-protein ligase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, GOC:ai, GOC:tb] synonym: "anaphase promoting complex inhibition" NARROW [] synonym: "anaphase promoting complex inhibitor" NARROW [] synonym: "anaphase-promoting complex inhibition" NARROW [] synonym: "anaphase-promoting complex inhibitor" NARROW [] synonym: "APC inhibition" NARROW [] synonym: "APC inhibitor" NARROW [] synonym: "down regulation of ubiquitin ligase activity" EXACT [] synonym: "down-regulation of ubiquitin ligase activity" EXACT [] synonym: "downregulation of ubiquitin ligase activity" EXACT [] synonym: "inhibition of ubiquitin ligase activity" NARROW [] synonym: "negative regulation of ubiquitin ligase activity" EXACT [GOC:tb] synonym: "SCF complex inhibitor" NARROW [] synonym: "ubiquitin ligase inhibitor" NARROW [] is_a: GO:0031397 ! negative regulation of protein ubiquitination is_a: GO:0051352 ! negative regulation of ligase activity is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity [Term] id: GO:0051445 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "control of meiotic cell cycle progression" EXACT [] synonym: "meiotic cell cycle control" EXACT [] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle relationship: regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051446 name: positive regulation of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of progression through meiotic cell cycle" NARROW [] synonym: "positive regulation of meiotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through meiotic cell cycle" NARROW [] synonym: "up regulation of progression through meiotic cell cycle" EXACT [] synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] synonym: "upregulation of progression through meiotic cell cycle" EXACT [] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle relationship: positively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051447 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle relationship: negatively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051448 name: gonadotropin-releasing hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with gonadotropin-releasing hormone, a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary and it is synthesized and released by the hypothalamus." [PMID:1984190] synonym: "gonadotrophin releasing hormone binding" EXACT [] is_a: GO:0017046 ! peptide hormone binding [Term] id: GO:0051449 name: thyrotropin-releasing hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system." [GOC:ai] synonym: "thyrotropin releasing hormone binding" EXACT [] is_a: GO:0017046 ! peptide hormone binding [Term] id: GO:0051450 name: myoblast proliferation namespace: biological_process def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0051451 name: myoblast migration namespace: biological_process def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] is_a: GO:0014812 ! muscle cell migration [Term] id: GO:0051452 name: intracellular pH reduction namespace: biological_process def: "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai] synonym: "cell pH reduction" EXACT [] synonym: "cellular acidification" EXACT [] synonym: "intracellular acidification" RELATED [] synonym: "reduction of cellular pH" EXACT [] synonym: "reduction of pH in cell" EXACT [] is_a: GO:0045851 ! pH reduction is_a: GO:0051453 ! regulation of intracellular pH [Term] id: GO:0051453 name: regulation of intracellular pH namespace: biological_process def: "Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb] synonym: "cell pH regulation" EXACT [] synonym: "cellular pH regulation" EXACT [] synonym: "pH regulation in cell" EXACT [] synonym: "regulation of cell pH" EXACT [] is_a: GO:0030641 ! regulation of cellular pH [Term] id: GO:0051454 name: intracellular pH elevation namespace: biological_process def: "Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai] synonym: "cell pH elevation" EXACT [] synonym: "cellular alkalinization" EXACT [] synonym: "elevation of cellular pH" EXACT [] synonym: "intracellular alkalinization" EXACT [] synonym: "pH elevation in cell" EXACT [] is_a: GO:0045852 ! pH elevation is_a: GO:0051453 ! regulation of intracellular pH [Term] id: GO:0051455 name: attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation namespace: biological_process def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb] comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis. synonym: "attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:dph, GOC:tb] synonym: "monopolar attachment" EXACT [] synonym: "sister kinetochore monoorientation" EXACT [] is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation relationship: part_of GO:0045143 ! homologous chromosome segregation [Term] id: GO:0051456 name: attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation namespace: biological_process def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore during meiosis II" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in meiosis II" RELATED [GOC:dph, GOC:tb] synonym: "meiotic bipolar attachment" RELATED [GOC:vw] is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation relationship: part_of GO:0045144 ! meiotic sister chromatid segregation [Term] id: GO:0051457 name: maintenance of protein location in nucleus namespace: biological_process def: "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] synonym: "maintenance of nuclear protein localization" EXACT [] synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of protein location in cell nucleus" EXACT [] synonym: "nuclear protein retention" NARROW [] synonym: "nuclear protein sequestering" NARROW [] synonym: "nuclear protein sequestration" NARROW [] synonym: "protein retention in nucleus" NARROW [] synonym: "protein sequestration in nucleus" NARROW [] synonym: "protein storage in nucleus" NARROW [] synonym: "protein-nuclear retention" NARROW [] synonym: "sequestration of protein in nucleus" NARROW [] synonym: "storage of protein in nucleus" NARROW [] is_a: GO:0072595 ! maintenance of protein localization to organelle relationship: part_of GO:0034504 ! protein localization to nucleus [Term] id: GO:0051458 name: corticotropin secretion namespace: biological_process def: "The regulated release of corticotropin, by a cell or group of cells. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [PMID:11027914] synonym: "ACTH secretion" EXACT [] synonym: "adrenocorticotropic hormone secretion" EXACT [] synonym: "adrenocorticotropin secretion" RELATED [GOC:dph, GOC:tb] synonym: "adrenotropic hormone secretion" EXACT [] synonym: "adrenotropin secretion" EXACT [] synonym: "corticotropic hormone secretion" EXACT [] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0051459 name: regulation of corticotropin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell or group of cells." [GOC:ai, GOC:dph] synonym: "regulation of ACTH secretion" EXACT [] synonym: "regulation of adrenocorticotropic hormone secretion" EXACT [GOC:dph] synonym: "regulation of adrenocorticotropin secretion" EXACT [] synonym: "regulation of adrenotropin hormone secretion" EXACT [] synonym: "regulation of adrenotropin secretion" EXACT [] synonym: "regulation of corticotropic hormone secretion" EXACT [] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0051458 ! corticotropin secretion [Term] id: GO:0051460 name: negative regulation of corticotropin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell or group of cells." [GOC:ai] synonym: "down regulation of adrenocorticotropin secretion" EXACT [] synonym: "down-regulation of adrenocorticotropin secretion" EXACT [] synonym: "downregulation of adrenocorticotropin secretion" EXACT [] synonym: "inhibition of adrenocorticotropin secretion" NARROW [] synonym: "negative regulation of ACTH secretion" EXACT [] synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT [] synonym: "negative regulation of adrenocorticotropin secretion" EXACT [] synonym: "negative regulation of adrenotropic hormone secretion" EXACT [] synonym: "negative regulation of adrenotropin secretion" EXACT [] synonym: "negative regulation of corticotropic hormone secretion" EXACT [] is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051459 ! regulation of corticotropin secretion relationship: negatively_regulates GO:0051458 ! corticotropin secretion [Term] id: GO:0051461 name: positive regulation of corticotropin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell or group of cells." [GOC:ai] synonym: "activation of adrenocorticotropin secretion" NARROW [] synonym: "positive regulation of ACTH secretion" EXACT [] synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT [] synonym: "positive regulation of adrenocorticotropin secretion" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of adrenotropic hormone secretion" EXACT [] synonym: "positive regulation of adrenotropin secretion" EXACT [] synonym: "positive regulation of corticotropic hormone secretion" EXACT [] synonym: "positive regulation of corticotropin secretion" EXACT [] synonym: "stimulation of adrenocorticotropin secretion" NARROW [] synonym: "up regulation of adrenocorticotropin secretion" EXACT [] synonym: "up-regulation of adrenocorticotropin secretion" EXACT [] synonym: "upregulation of adrenocorticotropin secretion" EXACT [] is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051459 ! regulation of corticotropin secretion relationship: positively_regulates GO:0051458 ! corticotropin secretion [Term] id: GO:0051462 name: regulation of cortisol secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells." [GOC:ai] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0043400 ! cortisol secretion [Term] id: GO:0051463 name: negative regulation of cortisol secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells." [GOC:ai] synonym: "down regulation of cortisol secretion" EXACT [] synonym: "down-regulation of cortisol secretion" EXACT [] synonym: "downregulation of cortisol secretion" EXACT [] synonym: "inhibition of cortisol secretion" NARROW [] is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051462 ! regulation of cortisol secretion relationship: negatively_regulates GO:0043400 ! cortisol secretion [Term] id: GO:0051464 name: positive regulation of cortisol secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells." [GOC:ai] synonym: "activation of cortisol secretion" NARROW [] synonym: "stimulation of cortisol secretion" NARROW [] synonym: "up regulation of cortisol secretion" EXACT [] synonym: "up-regulation of cortisol secretion" EXACT [] synonym: "upregulation of cortisol secretion" EXACT [] is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051462 ! regulation of cortisol secretion relationship: positively_regulates GO:0043400 ! cortisol secretion [Term] id: GO:0051465 name: negative regulation of corticotropin-releasing hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells." [GOC:ai] synonym: "down regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "down-regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "downregulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "inhibition of corticotropin-releasing hormone secretion" NARROW [] synonym: "negative regulation of corticotropin-releasing factor secretion" EXACT [] synonym: "negative regulation of CRF secretion" EXACT [] synonym: "negative regulation of CRH secretion" EXACT [] is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion is_a: GO:0046888 ! negative regulation of hormone secretion relationship: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion [Term] id: GO:0051466 name: positive regulation of corticotropin-releasing hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells." [GOC:ai] synonym: "activation of corticotropin-releasing hormone secretion" NARROW [] synonym: "positive regulation of corticotropin-releasing factor secretion" EXACT [] synonym: "positive regulation of CRF secretion" EXACT [] synonym: "positive regulation of CRH secretion" EXACT [] synonym: "stimulation of corticotropin-releasing hormone secretion" NARROW [] synonym: "up regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "up-regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "upregulation of corticotropin-releasing hormone secretion" EXACT [] is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion is_a: GO:0046887 ! positive regulation of hormone secretion relationship: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion [Term] id: GO:0051467 name: detection of steroid hormone stimulus namespace: biological_process def: "The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal." [GOC:ai] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0048545 ! response to steroid hormone stimulus [Term] id: GO:0051468 name: detection of glucocorticoid hormone stimulus namespace: biological_process def: "The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai] is_a: GO:0051384 ! response to glucocorticoid stimulus is_a: GO:0051467 ! detection of steroid hormone stimulus [Term] id: GO:0051469 name: vesicle fusion with vacuole namespace: biological_process alt_id: GO:0042146 def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai] synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED [] synonym: "heterotypic vacuole fusion, non-autophagic" RELATED [] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0007033 ! vacuole organization [Term] id: GO:0051470 name: ectoine transport namespace: biological_process def: "The directed movement of ectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai] subset: gosubset_prok is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0051471 name: ectoine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ectoine from one side of the membrane to the other. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai] subset: gosubset_prok is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0051472 name: glucosylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai] synonym: "glucosylglycerol metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0051473 name: glucosylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai] synonym: "glucosylglycerol anabolism" EXACT [] synonym: "glucosylglycerol biosynthesis" EXACT [] synonym: "glucosylglycerol formation" EXACT [] synonym: "glucosylglycerol synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0019401 ! alditol biosynthetic process is_a: GO:0051472 ! glucosylglycerol metabolic process [Term] id: GO:0051474 name: glucosylglycerol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a glucosylglycerol from one side of the membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0051475 name: glucosylglycerol transport namespace: biological_process def: "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015850 ! organic alcohol transport [Term] id: GO:0051476 name: mannosylglycerate transport namespace: biological_process def: "The directed movement of mannosylglycerate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0051477 name: mannosylglycerate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a mannosylglycerate from one side of the membrane to the other." [GOC:ai, PMID:15034926] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0051478 name: mannosylglycerate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai, PMID:11562374] synonym: "mannosylglycerate metabolism" EXACT [] is_a: GO:0044262 ! cellular carbohydrate metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0051479 name: mannosylglycerate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai] synonym: "mannosylglycerate anabolism" EXACT [] synonym: "mannosylglycerate biosynthesis" EXACT [] synonym: "mannosylglycerate formation" EXACT [] synonym: "mannosylglycerate synthesis" EXACT [] is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0051478 ! mannosylglycerate metabolic process [Term] id: GO:0051480 name: cytosolic calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah] synonym: "calcium ion homeostasis in cytoplasm" BROAD [] synonym: "calcium ion homeostasis in cytosol" EXACT [] synonym: "cytoplasmic calcium ion concentration regulation" BROAD [] synonym: "cytoplasmic calcium ion homeostasis" BROAD [] synonym: "cytosolic calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in cytoplasm" BROAD [] synonym: "regulation of calcium ion concentration in cytosol" EXACT [] synonym: "regulation of cytoplasmic calcium ion concentration" BROAD [] synonym: "regulation of cytosolic calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0051481 name: reduction of cytosolic calcium ion concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in the cytodol." [GOC:ai] synonym: "cytoplasmic calcium ion concentration reduction" BROAD [] synonym: "cytosolic calcium ion concentration reduction" EXACT [] synonym: "reduction of calcium ion concentration in cytoplasm" BROAD [] synonym: "reduction of calcium ion concentration in cytosol" EXACT [] synonym: "reduction of cytoplasmic calcium ion concentration" BROAD [] is_a: GO:0051480 ! cytosolic calcium ion homeostasis [Term] id: GO:0051482 name: elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger namespace: biological_process def: "Any process that increases the concentration of calcium ions in the cytosol that contributes to the process of G-protein signaling coupled to IP3 second messenger." [GOC:ai] synonym: "elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] synonym: "elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" RELATED [] synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] synonym: "elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" RELATED [] is_a: GO:0007204 ! elevation of cytosolic calcium ion concentration relationship: part_of GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger [Term] id: GO:0051483 name: terpenoid biosynthetic process, mevalonate-independent namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai] synonym: "mevalonate-independent terpene biosynthesis" NARROW [] synonym: "mevalonate-independent terpene biosynthetic process" NARROW [] synonym: "mevalonate-independent terpenoid biosynthesis" EXACT [] synonym: "mevalonate-independent terpenoid biosynthetic process" EXACT [] synonym: "terpene biosynthesis, mevalonate-independent" NARROW [] synonym: "terpene biosynthetic process, mevalonate-independent" NARROW [] synonym: "terpenoid anabolism, mevalonate-independent" EXACT [] synonym: "terpenoid formation, mevalonate-independent" EXACT [] synonym: "terpenoid synthesis, mevalonate-independent" EXACT [] is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0051484 name: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway involved in terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai] synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism" RELATED [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb] synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis" RELATED [] synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation" RELATED [] synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis" RELATED [] xref: MetaCyc:NONMEVIPP-PWY is_a: GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway relationship: part_of GO:0051483 ! terpenoid biosynthetic process, mevalonate-independent [Term] id: GO:0051485 name: terpenoid biosynthetic process, mevalonate-dependent namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai] synonym: "terpene biosynthesis, mevalonate-dependent" NARROW [] synonym: "terpene biosynthetic process, mevalonate-dependent" NARROW [] synonym: "terpenoid anabolism, mevalonate-dependent" EXACT [] synonym: "terpenoid formation, mevalonate-dependent" EXACT [] synonym: "terpenoid synthesis, mevalonate-dependent" EXACT [] is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0051486 name: isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway that contributes to terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai] synonym: "isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism" RELATED [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb] synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis" RELATED [] synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation" RELATED [] synonym: "isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis" RELATED [] is_a: GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway relationship: part_of GO:0051485 ! terpenoid biosynthetic process, mevalonate-dependent [Term] id: GO:0051487 name: activation of anaphase-promoting complex activity involved in meiotic cell cycle namespace: biological_process def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex during the meiotic cell cycle." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297] synonym: "activation of anaphase-promoting complex activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" RELATED [] synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" RELATED [] synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" RELATED [] synonym: "anaphase promoting complex activation during meiotic cell cycle" RELATED [] synonym: "anaphase-promoting complex activation during meiotic cell cycle" RELATED [] synonym: "APC activation during meiotic cell cycle" RELATED [] synonym: "meiotic anaphase promoting complex activation" RELATED [] synonym: "meiotic anaphase promoting complex activator" NARROW [] synonym: "meiotic anaphase-promoting complex activator" NARROW [] synonym: "meiotic APC activation" EXACT [] synonym: "meiotic APC activator" NARROW [] is_a: GO:0051441 ! positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle is_a: GO:0051488 ! activation of anaphase-promoting complex activity [Term] id: GO:0051488 name: activation of anaphase-promoting complex activity namespace: biological_process def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297] synonym: "activation of ubiquitin ligase activity of anaphase promoting complex" EXACT [] synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex" EXACT [] synonym: "activation of ubiquitin ligase activity of APC" EXACT [] synonym: "anaphase promoting complex activation" EXACT [] synonym: "anaphase promoting complex activator" NARROW [] synonym: "anaphase-promoting complex activation" EXACT [] synonym: "anaphase-promoting complex activator" NARROW [] synonym: "APC activation" EXACT [] synonym: "APC activator" NARROW [] is_a: GO:0051443 ! positive regulation of ubiquitin-protein ligase activity [Term] id: GO:0051489 name: regulation of filopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] synonym: "regulation of filopodia biosynthesis" EXACT [] synonym: "regulation of filopodia formation" EXACT [] synonym: "regulation of filopodium formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0060491 ! regulation of cell projection assembly relationship: regulates GO:0046847 ! filopodium assembly [Term] id: GO:0051490 name: negative regulation of filopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai] synonym: "down regulation of filopodium formation" EXACT [] synonym: "down-regulation of filopodium formation" EXACT [] synonym: "downregulation of filopodium formation" EXACT [] synonym: "inhibition of filopodium formation" NARROW [] synonym: "negative regulation of filopodia biosynthesis" EXACT [] synonym: "negative regulation of filopodia formation" EXACT [] synonym: "negative regulation of filopodium formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0051489 ! regulation of filopodium assembly relationship: negatively_regulates GO:0046847 ! filopodium assembly [Term] id: GO:0051491 name: positive regulation of filopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of filopodium formation" NARROW [] synonym: "positive regulation of filopodia biosynthesis" EXACT [] synonym: "positive regulation of filopodia formation" EXACT [] synonym: "positive regulation of filopodium formation" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of filopodium formation" NARROW [] synonym: "up regulation of filopodium formation" EXACT [] synonym: "up-regulation of filopodium formation" EXACT [] synonym: "upregulation of filopodium formation" EXACT [] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0051489 ! regulation of filopodium assembly relationship: positively_regulates GO:0046847 ! filopodium assembly [Term] id: GO:0051492 name: regulation of stress fiber assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] synonym: "regulation of stress fibre biosynthesis" RELATED [] synonym: "regulation of stress fibre formation" EXACT [] is_a: GO:0032231 ! regulation of actin filament bundle assembly relationship: regulates GO:0043149 ! stress fiber assembly [Term] id: GO:0051493 name: regulation of cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051494 name: negative regulation of cytoskeleton organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "down regulation of cytoskeleton organization" EXACT [] synonym: "down-regulation of cytoskeleton organization" EXACT [] synonym: "downregulation of cytoskeleton organization" EXACT [] synonym: "inhibition of cytoskeleton organization" NARROW [] synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization relationship: negatively_regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051495 name: positive regulation of cytoskeleton organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "activation of cytoskeleton organization" NARROW [] synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cytoskeleton organization" NARROW [] synonym: "up regulation of cytoskeleton organization" EXACT [] synonym: "up-regulation of cytoskeleton organization" EXACT [] synonym: "upregulation of cytoskeleton organization" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization relationship: positively_regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051496 name: positive regulation of stress fiber assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] synonym: "activation of stress fiber formation" NARROW [] synonym: "positive regulation of stress fibre biosynthesis" RELATED [] synonym: "positive regulation of stress fibre formation" RELATED [] synonym: "stimulation of stress fiber formation" NARROW [] synonym: "up regulation of stress fiber formation" RELATED [] synonym: "up-regulation of stress fiber formation" EXACT [] synonym: "upregulation of stress fiber formation" RELATED [] is_a: GO:0032233 ! positive regulation of actin filament bundle assembly is_a: GO:0051492 ! regulation of stress fiber assembly relationship: positively_regulates GO:0043149 ! stress fiber assembly [Term] id: GO:0051497 name: negative regulation of stress fiber assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] synonym: "down regulation of stress fiber formation" RELATED [] synonym: "down-regulation of stress fiber formation" EXACT [] synonym: "downregulation of stress fiber formation" RELATED [] synonym: "inhibition of stress fiber formation" NARROW [] synonym: "negative regulation of stress fibre biosynthesis" RELATED [] synonym: "negative regulation of stress fibre formation" RELATED [] is_a: GO:0032232 ! negative regulation of actin filament bundle assembly is_a: GO:0051492 ! regulation of stress fiber assembly relationship: negatively_regulates GO:0043149 ! stress fiber assembly [Term] id: GO:0051498 name: syn-copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate." [MetaCyc:RXN-8528] synonym: "diterpene cyclase activity" BROAD [] xref: EC:5.5.1.14 xref: MetaCyc:RXN-8528 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0051499 name: D-aminoacyl-tRNA deacylase activity namespace: molecular_function def: "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0051500 name: D-tyrosyl-tRNA(Tyr) deacylase activity namespace: molecular_function def: "Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine resides in charged tRNA." [PMID:14527667] is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity [Term] id: GO:0051501 name: diterpene phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units." [GOC:ai, http://www.onelook.com, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "diterpene phytoalexin metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0051502 name: diterpene phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses." [GOC:ai] synonym: "diterpene phytoalexin anabolism" EXACT [] synonym: "diterpene phytoalexin biosynthesis" EXACT [] synonym: "diterpene phytoalexin formation" EXACT [] synonym: "diterpene phytoalexin synthesis" EXACT [] is_a: GO:0051501 ! diterpene phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0051503 name: adenine nucleotide transport namespace: biological_process def: "The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015865 ! purine nucleotide transport [Term] id: GO:0051504 name: diterpene phytoalexin precursor biosynthetic process pathway namespace: biological_process def: "A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins." [MetaCyc:PWY-2981] synonym: "diterpene phytoalexin precursor anabolism pathway" EXACT [] synonym: "diterpene phytoalexin precursor formation pathway" EXACT [] synonym: "diterpene phytoalexin precursor synthesis pathway" EXACT [] xref: MetaCyc:PWY-2981 is_a: GO:0046246 ! terpene biosynthetic process relationship: part_of GO:0051502 ! diterpene phytoalexin biosynthetic process [Term] id: GO:0051505 name: cholesterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-cholesterol." [GOC:ai] is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051506 name: ergosterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-ergosterol." [GOC:ai] is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051507 name: beta-sitosterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-beta-sitosterol." [GOC:ai] is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051508 name: stigmasterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-stigmasterol." [GOC:ai] is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051509 name: tomatidine UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-tomatidine." [GOC:ai] is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051510 name: regulation of unidimensional cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0048638 ! regulation of developmental growth relationship: regulates GO:0009826 ! unidimensional cell growth [Term] id: GO:0051511 name: negative regulation of unidimensional cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] synonym: "down regulation of unidimensional cell growth" EXACT [] synonym: "down-regulation of unidimensional cell growth" EXACT [] synonym: "downregulation of unidimensional cell growth" EXACT [] synonym: "inhibition of unidimensional cell growth" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051510 ! regulation of unidimensional cell growth relationship: negatively_regulates GO:0009826 ! unidimensional cell growth [Term] id: GO:0051512 name: positive regulation of unidimensional cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] synonym: "activation of unidimensional cell growth" NARROW [] synonym: "stimulation of unidimensional cell growth" NARROW [] synonym: "up regulation of unidimensional cell growth" EXACT [] synonym: "up-regulation of unidimensional cell growth" EXACT [] synonym: "upregulation of unidimensional cell growth" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051510 ! regulation of unidimensional cell growth relationship: positively_regulates GO:0009826 ! unidimensional cell growth [Term] id: GO:0051513 name: regulation of monopolar cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] is_a: GO:0051510 ! regulation of unidimensional cell growth relationship: regulates GO:0042814 ! monopolar cell growth [Term] id: GO:0051514 name: negative regulation of monopolar cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] synonym: "down regulation of monopolar cell growth" EXACT [] synonym: "down-regulation of monopolar cell growth" EXACT [] synonym: "downregulation of monopolar cell growth" EXACT [] synonym: "inhibition of monopolar cell growth" NARROW [] is_a: GO:0051511 ! negative regulation of unidimensional cell growth is_a: GO:0051513 ! regulation of monopolar cell growth relationship: negatively_regulates GO:0042814 ! monopolar cell growth [Term] id: GO:0051515 name: positive regulation of monopolar cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] synonym: "stimulation of monopolar cell growth" NARROW [] synonym: "up regulation of monopolar cell growth" EXACT [] synonym: "up-regulation of monopolar cell growth" EXACT [] synonym: "upregulation of monopolar cell growth" EXACT [] is_a: GO:0051512 ! positive regulation of unidimensional cell growth is_a: GO:0051513 ! regulation of monopolar cell growth relationship: positively_regulates GO:0042814 ! monopolar cell growth [Term] id: GO:0051516 name: regulation of bipolar cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] is_a: GO:0051510 ! regulation of unidimensional cell growth relationship: regulates GO:0042815 ! bipolar cell growth [Term] id: GO:0051517 name: negative regulation of bipolar cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] synonym: "down regulation of bipolar cell growth" EXACT [] synonym: "down-regulation of bipolar cell growth" EXACT [] synonym: "downregulation of bipolar cell growth" EXACT [] synonym: "inhibition of bipolar cell growth" NARROW [] is_a: GO:0051511 ! negative regulation of unidimensional cell growth is_a: GO:0051516 ! regulation of bipolar cell growth relationship: negatively_regulates GO:0042815 ! bipolar cell growth [Term] id: GO:0051518 name: positive regulation of bipolar cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] synonym: "stimulation of bipolar cell growth" NARROW [] synonym: "up regulation of bipolar cell growth" EXACT [] synonym: "up-regulation of bipolar cell growth" EXACT [] synonym: "upregulation of bipolar cell growth" EXACT [] is_a: GO:0051512 ! positive regulation of unidimensional cell growth is_a: GO:0051516 ! regulation of bipolar cell growth relationship: positively_regulates GO:0042815 ! bipolar cell growth [Term] id: GO:0051519 name: activation of bipolar cell growth namespace: biological_process def: "Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] synonym: "NETO" EXACT [GOC:mah, GOC:vw] synonym: "new end take off" EXACT [GOC:mah, GOC:vw] is_a: GO:0051518 ! positive regulation of bipolar cell growth [Term] id: GO:0051520 name: termination of bipolar cell growth namespace: biological_process def: "Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] is_a: GO:0051517 ! negative regulation of bipolar cell growth [Term] id: GO:0051521 name: termination of monopolar cell growth namespace: biological_process def: "Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell." [GOC:ai] is_a: GO:0051514 ! negative regulation of monopolar cell growth [Term] id: GO:0051522 name: activation of monopolar cell growth namespace: biological_process def: "Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] is_a: GO:0051515 ! positive regulation of monopolar cell growth [Term] id: GO:0051523 name: cell growth mode switching, monopolar to bipolar namespace: biological_process def: "The process in which a cell switches from monopolar cell growth to bipolar cell growth." [GOC:ai] is_a: GO:0051510 ! regulation of unidimensional cell growth [Term] id: GO:0051524 name: cell growth mode switch, bipolar to monopolar namespace: biological_process def: "The process in which a cell switches from bipolar cell growth to monopolar cell growth." [GOC:ai] is_a: GO:0051510 ! regulation of unidimensional cell growth [Term] id: GO:0051525 name: NFAT protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system." [PMID:15928679] synonym: "NFAT binding" EXACT [] synonym: "nuclear factor of activated T cell protein binding" EXACT [] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0051526 name: NFAT1 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with NFAT1 (nuclear factor of activated T cells 1 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] synonym: "NFATc2 binding" EXACT [] synonym: "NFATp binding" EXACT [] is_a: GO:0051525 ! NFAT protein binding [Term] id: GO:0051527 name: NFAT2 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with NFAT2 (nuclear factor of activated T cells 2 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] synonym: "NFATc binding" EXACT [] synonym: "NFATc1 binding" EXACT [] is_a: GO:0051525 ! NFAT protein binding [Term] id: GO:0051528 name: NFAT3 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with NFAT3 (nuclear factor of activated T cells 3 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] synonym: "NFATc4 binding" EXACT [] is_a: GO:0051525 ! NFAT protein binding [Term] id: GO:0051529 name: NFAT4 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with NFAT4 (nuclear factor of activated T cells 4 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] synonym: "NFATc3 binding" RELATED [] synonym: "NFATx binding" EXACT [] is_a: GO:0051525 ! NFAT protein binding [Term] id: GO:0051530 name: NFAT5 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with NFAT1 (nuclear factor of activated T cells 1 protein), a member of the NFAT transcription factor family which is not calcium regulated." [GOC:ai] synonym: "non-calcium-regulated NFAT protein binding" EXACT [] is_a: GO:0051525 ! NFAT protein binding [Term] id: GO:0051531 name: NFAT protein import into nucleus namespace: biological_process def: "The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane." [PMID:11983154, PMID:15870113, PMID:15928679] synonym: "NFAT protein import into cell nucleus" EXACT [] synonym: "NFAT protein nuclear translocation" EXACT [] synonym: "NFAT protein nucleus import" EXACT [] synonym: "NFAT protein transport from cytoplasm to nucleus" EXACT [] synonym: "NFAT protein-nucleus import" EXACT [] is_a: GO:0042991 ! transcription factor import into nucleus [Term] id: GO:0051532 name: regulation of NFAT protein import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] synonym: "regulation of NFAT protein import into cell nucleus" EXACT [] synonym: "regulation of NFAT protein transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of NFAT protein-nucleus import" EXACT [] is_a: GO:0042990 ! regulation of transcription factor import into nucleus relationship: regulates GO:0051531 ! NFAT protein import into nucleus [Term] id: GO:0051533 name: positive regulation of NFAT protein import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] synonym: "activation of NFAT protein import into nucleus" NARROW [] synonym: "positive regulation of NFAT protein import into cell nucleus" EXACT [] synonym: "positive regulation of NFAT protein transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of NFAT protein-nucleus import" EXACT [] synonym: "stimulation of NFAT protein import into nucleus" NARROW [] synonym: "up regulation of NFAT protein import into nucleus" EXACT [] synonym: "up-regulation of NFAT protein import into nucleus" EXACT [] synonym: "upregulation of NFAT protein import into nucleus" EXACT [] is_a: GO:0042993 ! positive regulation of transcription factor import into nucleus is_a: GO:0051532 ! regulation of NFAT protein import into nucleus relationship: positively_regulates GO:0051531 ! NFAT protein import into nucleus [Term] id: GO:0051534 name: negative regulation of NFAT protein import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] synonym: "down regulation of NFAT protein import into nucleus" EXACT [] synonym: "down-regulation of NFAT protein import into nucleus" EXACT [] synonym: "downregulation of NFAT protein import into nucleus" EXACT [] synonym: "inhibition of NFAT protein import into nucleus" NARROW [] synonym: "negative regulation of NFAT protein import into cell nucleus" EXACT [] synonym: "negative regulation of NFAT protein transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of NFAT protein-nucleus import" EXACT [] is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus is_a: GO:0051532 ! regulation of NFAT protein import into nucleus relationship: negatively_regulates GO:0051531 ! NFAT protein import into nucleus [Term] id: GO:0051535 name: syntaxin-5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-5." [GOC:ai, PMID:12388752] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0051536 name: iron-sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] synonym: "Fe/S binding" EXACT [] synonym: "iron sulfur cluster binding" EXACT [] synonym: "iron sulphur cluster binding" EXACT [] synonym: "iron-sulphur cluster binding" EXACT [] is_a: GO:0051540 ! metal cluster binding [Term] id: GO:0051537 name: 2 iron, 2 sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] synonym: "2 Fe 2 S cluster binding" EXACT [] synonym: "2 iron, 2 sulphur cluster binding" EXACT [] synonym: "2Fe-2S cluster binding" EXACT [] synonym: "diiron disulfide cluster binding" EXACT [] synonym: "diiron disulphide cluster binding" EXACT [] synonym: "iron-sulfur cluster 2Fe-2S binding" EXACT [] synonym: "iron-sulphur cluster 2Fe-2S binding" EXACT [] is_a: GO:0051536 ! iron-sulfur cluster binding [Term] id: GO:0051538 name: 3 iron, 4 sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] synonym: "3 Fe 4 S cluster binding" EXACT [] synonym: "3 iron, 4 sulphur cluster binding" EXACT [] synonym: "3Fe-4S cluster binding" EXACT [] synonym: "iron-sulfur cluster 3Fe-4S binding" EXACT [] synonym: "iron-sulphur cluster 3Fe-4S binding" EXACT [] synonym: "triiron tetrasulfide cluster binding" EXACT [] synonym: "triiron tetrasulphide cluster binding" EXACT [] is_a: GO:0051536 ! iron-sulfur cluster binding [Term] id: GO:0051539 name: 4 iron, 4 sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] synonym: "4 Fe 4 S cluster binding" EXACT [] synonym: "4 iron, 4 sulphur cluster binding" EXACT [] synonym: "4Fe-4S cluster binding" EXACT [] synonym: "iron-sulfur cluster 4Fe-4S binding" EXACT [] synonym: "iron-sulphur cluster 4Fe-4S binding" EXACT [] synonym: "tetrairon tetrasulfide cluster binding" EXACT [] synonym: "tetrairon tetrasulphide cluster binding" EXACT [] is_a: GO:0051536 ! iron-sulfur cluster binding [Term] id: GO:0051540 name: metal cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0051541 name: elastin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [http://www.onelook.com] synonym: "elastin metabolism" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0051542 name: elastin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries." [GOC:ai] is_a: GO:0009101 ! glycoprotein biosynthetic process is_a: GO:0051541 ! elastin metabolic process [Term] id: GO:0051543 name: regulation of elastin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process relationship: regulates GO:0051542 ! elastin biosynthetic process [Term] id: GO:0051544 name: positive regulation of elastin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] synonym: "activation of elastin biosynthetic process" NARROW [] synonym: "stimulation of elastin biosynthetic process" NARROW [] synonym: "up regulation of elastin biosynthetic process" EXACT [] synonym: "up-regulation of elastin biosynthetic process" EXACT [] synonym: "upregulation of elastin biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0051543 ! regulation of elastin biosynthetic process relationship: positively_regulates GO:0051542 ! elastin biosynthetic process [Term] id: GO:0051545 name: negative regulation of elastin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] synonym: "down regulation of elastin biosynthetic process" EXACT [] synonym: "down-regulation of elastin biosynthetic process" EXACT [] synonym: "downregulation of elastin biosynthetic process" EXACT [] synonym: "inhibition of elastin biosynthetic process" NARROW [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0051543 ! regulation of elastin biosynthetic process relationship: negatively_regulates GO:0051542 ! elastin biosynthetic process [Term] id: GO:0051546 name: keratinocyte migration namespace: biological_process def: "The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0016477 ! cell migration [Term] id: GO:0051547 name: regulation of keratinocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of keratinocyte migration." [GOC:ai] is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0051546 ! keratinocyte migration [Term] id: GO:0051548 name: negative regulation of keratinocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration." [GOC:ai] synonym: "down regulation of keratinocyte migration" EXACT [] synonym: "down-regulation of keratinocyte migration" EXACT [] synonym: "downregulation of keratinocyte migration" EXACT [] synonym: "inhibition of keratinocyte migration" NARROW [] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0051547 ! regulation of keratinocyte migration relationship: negatively_regulates GO:0051546 ! keratinocyte migration [Term] id: GO:0051549 name: positive regulation of keratinocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of keratinocyte migration." [GOC:ai] synonym: "activation of keratinocyte migration" NARROW [] synonym: "stimulation of keratinocyte migration" NARROW [] synonym: "up regulation of keratinocyte migration" EXACT [] synonym: "up-regulation of keratinocyte migration" EXACT [] synonym: "upregulation of keratinocyte migration" EXACT [] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0051547 ! regulation of keratinocyte migration relationship: positively_regulates GO:0051546 ! keratinocyte migration [Term] id: GO:0051550 name: aurone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides." [CHEBI:47964, GOC:curators] synonym: "aurone metabolism" EXACT [] synonym: "benzalcoumaran-3-one metabolic process" EXACT [] synonym: "benzalcoumaran-3-one metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0042440 ! pigment metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0051551 name: aurone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments." [GOC:ai] synonym: "benzalcoumaran-3-one biosynthesis" EXACT [] synonym: "benzalcoumaran-3-one biosynthetic process" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0051550 ! aurone metabolic process [Term] id: GO:0051552 name: flavone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [http://www.onelook.com] synonym: "2-phenyl-4H-1-benzopyran-4-one metabolic process" NARROW [] synonym: "2-phenyl-4H-1-benzopyran-4-one metabolism" NARROW [] synonym: "2-phenylchromone metabolic process" NARROW [] synonym: "2-phenylchromone metabolism" NARROW [] synonym: "flavone metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0042440 ! pigment metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0051553 name: flavone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [GOC:ai] synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthesis" NARROW [] synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthetic process" NARROW [] synonym: "2-phenylchromone biosynthesis" NARROW [] synonym: "2-phenylchromone biosynthetic process" NARROW [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0051552 ! flavone metabolic process [Term] id: GO:0051554 name: flavonol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [PMID:11402179] synonym: "flavonol metabolism" EXACT [] is_a: GO:0051552 ! flavone metabolic process [Term] id: GO:0051555 name: flavonol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [GOC:ai] xref: MetaCyc:PWY-3101 is_a: GO:0051553 ! flavone biosynthetic process is_a: GO:0051554 ! flavonol metabolic process [Term] id: GO:0051556 name: leucoanthocyanidin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai] synonym: "leucoanthocyanidin metabolism" EXACT [] xref: MetaCyc:PWY1F-823 is_a: GO:0009812 ! flavonoid metabolic process [Term] id: GO:0051557 name: leucoanthocyanidin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0051556 ! leucoanthocyanidin metabolic process [Term] id: GO:0051558 name: phlobaphene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179] synonym: "phlobaphene metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0051559 name: phlobaphene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0051558 ! phlobaphene metabolic process [Term] id: GO:0051560 name: mitochondrial calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah] synonym: "calcium ion homeostasis in mitochondria" EXACT [] synonym: "calcium ion homeostasis in mitochondrion" EXACT [] synonym: "mitochondrial calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in mitochondria" EXACT [] synonym: "regulation of calcium ion concentration in mitochondrion" EXACT [] synonym: "regulation of mitochondrial calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0051561 name: elevation of mitochondrial calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in mitochondria." [GOC:ai] synonym: "elevation of calcium ion concentration in mitochondria" EXACT [] synonym: "elevation of calcium ion concentration in mitochondrion" EXACT [] synonym: "mitochondrial calcium ion concentration elevation" EXACT [] is_a: GO:0051560 ! mitochondrial calcium ion homeostasis [Term] id: GO:0051562 name: reduction of mitochondrial calcium ion concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in mitochondria." [GOC:ai] synonym: "mitochondrial calcium ion concentration reduction" EXACT [] synonym: "reduction of calcium ion concentration in mitochondria" EXACT [] synonym: "reduction of calcium ion concentration in mitochondrion" EXACT [] is_a: GO:0051560 ! mitochondrial calcium ion homeostasis [Term] id: GO:0051563 name: smooth endoplasmic reticulum calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings." [GOC:ai, GOC:mah] synonym: "calcium ion homeostasis in smooth endoplasmic reticulum" EXACT [] synonym: "calcium ion homeostasis in smooth ER" EXACT [] synonym: "regulation of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] synonym: "regulation of calcium ion concentration in smooth ER" EXACT [] synonym: "regulation of smooth endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "regulation of smooth ER calcium ion concentration" EXACT [] synonym: "smooth endoplasmic reticulum calcium ion concentration regulation" EXACT [] synonym: "smooth ER calcium ion concentration regulation" EXACT [] synonym: "smooth ER calcium ion homeostasis" EXACT [] is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0051564 name: elevation of smooth endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai] synonym: "elevation of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] synonym: "elevation of smooth ER calcium ion concentration" EXACT [] synonym: "smooth endoplasmic reticulum calcium ion concentration elevation" EXACT [] is_a: GO:0032470 ! elevation of endoplasmic reticulum calcium ion concentration is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0051565 name: reduction of smooth endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai] synonym: "reduction of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] synonym: "reduction of calcium ion concentration in smooth ER" EXACT [] synonym: "reduction of smooth ER calcium ion concentration" EXACT [] synonym: "smooth endoplasmic reticulum calcium ion concentration reduction" EXACT [] synonym: "smooth ER calcium ion concentration reduction" EXACT [] is_a: GO:0032471 ! reduction of endoplasmic reticulum calcium ion concentration is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0051566 name: anthocyanidin-3-glucoside rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP." [PMID:8130800] synonym: "3RT activity" BROAD [] synonym: "anthocyanidin 3-glucoside-rhamnosyltransferase activity" EXACT [] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0051567 name: histone H3-K9 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone." [GOC:ai] synonym: "histone H3 K9 methylation" EXACT [] synonym: "histone H3K9me" EXACT [] synonym: "histone lysine H3 K9 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0051568 name: histone H3-K4 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] synonym: "histone H3 K4 methylation" EXACT [] synonym: "histone H3K4me" EXACT [] synonym: "histone lysine H3 K4 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0051569 name: regulation of histone H3-K4 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:ai] is_a: GO:0031060 ! regulation of histone methylation relationship: regulates GO:0051568 ! histone H3-K4 methylation [Term] id: GO:0051570 name: regulation of histone H3-K9 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] is_a: GO:0031060 ! regulation of histone methylation relationship: regulates GO:0051567 ! histone H3-K9 methylation [Term] id: GO:0051571 name: positive regulation of histone H3-K4 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah] synonym: "activation of histone H3-K4 methylation" NARROW [] synonym: "stimulation of histone H3-K4 methylation" NARROW [] synonym: "up regulation of histone H3-K4 methylation" EXACT [] synonym: "up-regulation of histone H3-K4 methylation" EXACT [] synonym: "upregulation of histone H3-K4 methylation" EXACT [] is_a: GO:0031062 ! positive regulation of histone methylation is_a: GO:0051569 ! regulation of histone H3-K4 methylation relationship: positively_regulates GO:0051568 ! histone H3-K4 methylation [Term] id: GO:0051572 name: negative regulation of histone H3-K4 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah] synonym: "down regulation of histone H3-K4 methylation" EXACT [] synonym: "down-regulation of histone H3-K4 methylation" EXACT [] synonym: "downregulation of histone H3-K4 methylation" EXACT [] synonym: "inhibition of histone H3-K4 methylation" NARROW [] is_a: GO:0031061 ! negative regulation of histone methylation is_a: GO:0051569 ! regulation of histone H3-K4 methylation relationship: negatively_regulates GO:0051568 ! histone H3-K4 methylation [Term] id: GO:0051573 name: negative regulation of histone H3-K9 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] synonym: "down regulation of histone H3-K9 methylation" EXACT [] synonym: "down-regulation of histone H3-K9 methylation" EXACT [] synonym: "downregulation of histone H3-K9 methylation" EXACT [] synonym: "inhibition of histone H3-K9 methylation" NARROW [] is_a: GO:0031061 ! negative regulation of histone methylation is_a: GO:0051570 ! regulation of histone H3-K9 methylation relationship: negatively_regulates GO:0051567 ! histone H3-K9 methylation [Term] id: GO:0051574 name: positive regulation of histone H3-K9 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] synonym: "activation of histone H3-K9 methylation" NARROW [] synonym: "stimulation of histone H3-K9 methylation" NARROW [] synonym: "up regulation of histone H3-K9 methylation" EXACT [] synonym: "up-regulation of histone H3-K9 methylation" EXACT [] synonym: "upregulation of histone H3-K9 methylation" EXACT [] is_a: GO:0031062 ! positive regulation of histone methylation is_a: GO:0051570 ! regulation of histone H3-K9 methylation relationship: positively_regulates GO:0051567 ! histone H3-K9 methylation [Term] id: GO:0051575 name: 5'-deoxyribose-5-phosphate lyase activity namespace: molecular_function def: "Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site." [PMID:11251121, PMID:16120966] synonym: "5'-deoxyribose phosphate activity" EXACT [] synonym: "dRP lyase activity" BROAD [] synonym: "dRPase activity" BROAD [] is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0051576 name: Myf5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the muscle regulatory factor Myf5." [GOC:ai] is_a: GO:0043426 ! MRF binding [Term] id: GO:0051577 name: MyoD binding namespace: molecular_function def: "Interacting selectively and non-covalently with the muscle regulatory factor MyoD." [GOC:ai] is_a: GO:0043426 ! MRF binding [Term] id: GO:0051578 name: Mrf4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the muscle regulatory factor Mrf4." [GOC:ai] is_a: GO:0043426 ! MRF binding [Term] id: GO:0051579 name: myogenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the muscle regulatory factor myogenin." [GOC:ai] is_a: GO:0043426 ! MRF binding [Term] id: GO:0051580 name: regulation of neurotransmitter uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurotransmitter reuptake" EXACT [] is_a: GO:0050804 ! regulation of synaptic transmission is_a: GO:0051588 ! regulation of neurotransmitter transport relationship: regulates GO:0001504 ! neurotransmitter uptake [Term] id: GO:0051581 name: negative regulation of neurotransmitter uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] synonym: "down regulation of neurotransmitter uptake" EXACT [] synonym: "down-regulation of neurotransmitter uptake" EXACT [] synonym: "downregulation of neurotransmitter uptake" EXACT [] synonym: "negative regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051589 ! negative regulation of neurotransmitter transport relationship: negatively_regulates GO:0001504 ! neurotransmitter uptake [Term] id: GO:0051582 name: positive regulation of neurotransmitter uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] synonym: "activation of neurotransmitter uptake" NARROW [] synonym: "positive regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of neurotransmitter uptake" NARROW [] synonym: "up regulation of neurotransmitter uptake" EXACT [] synonym: "up-regulation of neurotransmitter uptake" EXACT [] synonym: "upregulation of neurotransmitter uptake" EXACT [] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051590 ! positive regulation of neurotransmitter transport relationship: positively_regulates GO:0001504 ! neurotransmitter uptake [Term] id: GO:0051583 name: dopamine uptake namespace: biological_process def: "The directed movement of dopamine into a cell, typically presynaptic neurons or glial cells. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] synonym: "dopamine import" EXACT [GOC:dph, GOC:tb] synonym: "dopamine reuptake" EXACT [] is_a: GO:0015872 ! dopamine transport is_a: GO:0051934 ! catecholamine uptake involved in synaptic transmission relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0051584 name: regulation of dopamine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell." [GOC:ai] synonym: "regulation of dopamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission relationship: regulates GO:0051583 ! dopamine uptake [Term] id: GO:0051585 name: negative regulation of dopamine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai] synonym: "down regulation of dopamine uptake" EXACT [] synonym: "down-regulation of dopamine uptake" EXACT [] synonym: "downregulation of dopamine uptake" EXACT [] synonym: "negative regulation of dopamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051584 ! regulation of dopamine uptake is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission relationship: negatively_regulates GO:0051583 ! dopamine uptake [Term] id: GO:0051586 name: positive regulation of dopamine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai] synonym: "activation of dopamine uptake" NARROW [] synonym: "positive regulation of dopamine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of dopamine uptake" NARROW [] synonym: "up regulation of dopamine uptake" EXACT [] synonym: "up-regulation of dopamine uptake" EXACT [] synonym: "upregulation of dopamine uptake" EXACT [] is_a: GO:0051584 ! regulation of dopamine uptake is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission relationship: positively_regulates GO:0051583 ! dopamine uptake [Term] id: GO:0051587 name: inhibition of dopamine uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of dopamine into a cell." [GOC:ai] synonym: "inhibition of dopamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051585 ! negative regulation of dopamine uptake is_a: GO:0051609 ! inhibition of neurotransmitter uptake [Term] id: GO:0051588 name: regulation of neurotransmitter transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0006836 ! neurotransmitter transport [Term] id: GO:0051589 name: negative regulation of neurotransmitter transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of neurotransmitter transport" EXACT [] synonym: "down-regulation of neurotransmitter transport" EXACT [] synonym: "downregulation of neurotransmitter transport" EXACT [] synonym: "inhibition of neurotransmitter transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport relationship: negatively_regulates GO:0006836 ! neurotransmitter transport [Term] id: GO:0051590 name: positive regulation of neurotransmitter transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of neurotransmitter transport" NARROW [] synonym: "stimulation of neurotransmitter transport" NARROW [] synonym: "up regulation of neurotransmitter transport" EXACT [] synonym: "up-regulation of neurotransmitter transport" EXACT [] synonym: "upregulation of neurotransmitter transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport relationship: positively_regulates GO:0006836 ! neurotransmitter transport [Term] id: GO:0051591 name: response to cAMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:ai] synonym: "response to 3',5' cAMP" EXACT [] synonym: "response to 3',5'-cAMP" EXACT [] synonym: "response to adenosine 3',5'-cyclophosphate" EXACT [] synonym: "response to cyclic AMP" EXACT [] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0051592 name: response to calcium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai] synonym: "response to Ca2+ ion" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0051593 name: response to folic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:ai] synonym: "cellular response to folate" EXACT [GOC:mah] synonym: "cellular response to vitamin B9" EXACT [GOC:mah] is_a: GO:0001101 ! response to acid is_a: GO:0033273 ! response to vitamin [Term] id: GO:0051594 name: detection of glucose namespace: biological_process def: "The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "glucose detection" EXACT [] synonym: "glucose perception" RELATED [] synonym: "glucose sensing" RELATED [] is_a: GO:0009732 ! detection of hexose stimulus is_a: GO:0009749 ! response to glucose stimulus [Term] id: GO:0051595 name: response to methylglyoxal namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus." [GOC:ai] subset: gosubset_prok synonym: "response to pyruvaldehyde" EXACT [] is_a: GO:0009636 ! response to toxin [Term] id: GO:0051596 name: methylglyoxal catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] subset: gosubset_prok synonym: "methylglyoxal breakdown" EXACT [] synonym: "methylglyoxal catabolism" EXACT [] synonym: "methylglyoxal degradation" EXACT [] is_a: GO:0009438 ! methylglyoxal metabolic process is_a: GO:0046185 ! aldehyde catabolic process [Term] id: GO:0051597 name: response to methylmercury namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:ai] synonym: "response to CH3-Hg+" EXACT [] synonym: "response to MeHg+" EXACT [] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0051598 name: meiotic recombination checkpoint namespace: biological_process def: "A checkpoint that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes." [PMID:14718568] synonym: "pachytene checkpoint" EXACT [] is_a: GO:0033313 ! meiotic cell cycle checkpoint is_a: GO:0045835 ! negative regulation of meiosis relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0051599 name: response to hydrostatic pressure namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [Wikipedia:Hydrostatic_pressure] synonym: "response to biomechanical stress" BROAD [] synonym: "response to static fluid pressure" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0051600 name: regulation of endocytosis by exocyst localization namespace: biological_process def: "Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai, GOC:dph, GOC:tb] synonym: "regulation of endocytosis by exocyst localisation" EXACT [GOC:mah] synonym: "regulation of site selection of endocytosis" RELATED [] synonym: "relocation of endocytosis" RELATED [] synonym: "spatial regulation of endocytosis" RELATED [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051601 ! exocyst localization [Term] id: GO:0051601 name: exocyst localization namespace: biological_process def: "Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai] synonym: "establishment and maintenance of exocyst localization" EXACT [] synonym: "exocyst localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization [Term] id: GO:0051602 name: response to electrical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai] synonym: "response to electricity" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0051603 name: proteolysis involved in cellular protein catabolic process namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "peptidolysis during cellular protein catabolic process" RELATED [] synonym: "peptidolysis during cellular protein catabolism" RELATED [] synonym: "peptidolysis involved in cellular protein catabolic process" EXACT [] synonym: "peptidolysis involved in cellular protein catabolism" EXACT [] synonym: "proteolysis during cellular protein catabolic process" RELATED [] synonym: "proteolysis during cellular protein catabolism" RELATED [] is_a: GO:0006508 ! proteolysis relationship: part_of GO:0044257 ! cellular protein catabolic process [Term] id: GO:0051604 name: protein maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: gosubset_prok is_a: GO:0019538 ! protein metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0051605 name: protein maturation by peptide bond cleavage namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein." [GOC:ai, GOC:mah] synonym: "peptidolysis during protein maturation" RELATED [GOC:mah] synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah] synonym: "protein maturation by proteolysis" RELATED [GOC:mah] is_a: GO:0006508 ! proteolysis is_a: GO:0016485 ! protein processing [Term] id: GO:0051606 name: detection of stimulus namespace: biological_process def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "perception of stimulus" RELATED [] synonym: "stimulus detection" EXACT [] synonym: "stimulus sensing" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051607 name: defense response to virus namespace: biological_process def: "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] synonym: "antiviral response" EXACT [] synonym: "defence response to virus" EXACT [] synonym: "defense response to viruses" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0006952 ! defense response is_a: GO:0009615 ! response to virus [Term] id: GO:0051608 name: histamine transport namespace: biological_process def: "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0015837 ! amine transport [Term] id: GO:0051609 name: inhibition of neurotransmitter uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of a neurotransmitter into a cell." [GOC:ai] synonym: "inhibition of neurotransmitter import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake [Term] id: GO:0051610 name: serotonin uptake namespace: biological_process def: "The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] synonym: "5-HT uptake" EXACT [] synonym: "5-hydroxytryptamine uptake" EXACT [] synonym: "5HT uptake" EXACT [] synonym: "serotonin import" EXACT [GOC:dph, GOC:tb] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0006837 ! serotonin transport [Term] id: GO:0051611 name: regulation of serotonin uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell." [GOC:ai] synonym: "regulation of 5-HT uptake" EXACT [] synonym: "regulation of 5-hydroxytryptamine uptake" EXACT [] synonym: "regulation of 5HT uptake" EXACT [] synonym: "regulation of serotonin import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051952 ! regulation of amine transport relationship: regulates GO:0051610 ! serotonin uptake [Term] id: GO:0051612 name: negative regulation of serotonin uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai] synonym: "down regulation of serotonin uptake" EXACT [] synonym: "down-regulation of serotonin uptake" EXACT [] synonym: "downregulation of serotonin uptake" EXACT [] synonym: "negative regulation of 5-HT uptake" EXACT [] synonym: "negative regulation of 5-hydroxytryptamine uptake" EXACT [] synonym: "negative regulation of 5HT uptake" EXACT [] synonym: "negative regulation of serotonin import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051611 ! regulation of serotonin uptake is_a: GO:0051953 ! negative regulation of amine transport relationship: negatively_regulates GO:0051610 ! serotonin uptake [Term] id: GO:0051613 name: positive regulation of serotonin uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai] synonym: "activation of serotonin uptake" NARROW [] synonym: "positive regulation of 5-HT uptake" EXACT [] synonym: "positive regulation of 5-hydroxytryptamine uptake" EXACT [] synonym: "positive regulation of 5HT uptake" EXACT [] synonym: "positive regulation of serotonin import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of serotonin uptake" NARROW [] synonym: "up regulation of serotonin uptake" EXACT [] synonym: "up-regulation of serotonin uptake" EXACT [] synonym: "upregulation of serotonin uptake" EXACT [] is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051611 ! regulation of serotonin uptake is_a: GO:0051954 ! positive regulation of amine transport relationship: positively_regulates GO:0051610 ! serotonin uptake [Term] id: GO:0051614 name: inhibition of serotonin uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of serotonin into a cell." [GOC:ai] synonym: "inhibition of 5-HT uptake" EXACT [] synonym: "inhibition of 5-hydroxytryptamine uptake" EXACT [] synonym: "inhibition of 5HT uptake" EXACT [] synonym: "inhibition of serotonin import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051612 ! negative regulation of serotonin uptake [Term] id: GO:0051615 name: histamine uptake namespace: biological_process def: "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] synonym: "histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0051608 ! histamine transport [Term] id: GO:0051616 name: regulation of histamine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." [GOC:ai] synonym: "regulation of histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051952 ! regulation of amine transport relationship: regulates GO:0051615 ! histamine uptake [Term] id: GO:0051617 name: negative regulation of histamine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] synonym: "down regulation of histamine uptake" EXACT [] synonym: "down-regulation of histamine uptake" EXACT [] synonym: "downregulation of histamine uptake" EXACT [] synonym: "negative regulation of histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051616 ! regulation of histamine uptake is_a: GO:0051953 ! negative regulation of amine transport relationship: negatively_regulates GO:0051615 ! histamine uptake [Term] id: GO:0051618 name: positive regulation of histamine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] synonym: "activation of histamine uptake" NARROW [] synonym: "positive regulation of histamine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of histamine uptake" NARROW [] synonym: "up regulation of histamine uptake" EXACT [] synonym: "up-regulation of histamine uptake" EXACT [] synonym: "upregulation of histamine uptake" EXACT [] is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051616 ! regulation of histamine uptake is_a: GO:0051954 ! positive regulation of amine transport relationship: positively_regulates GO:0051615 ! histamine uptake [Term] id: GO:0051619 name: inhibition of histamine uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of histamine into a cell." [GOC:ai] synonym: "inhibition of histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051617 ! negative regulation of histamine uptake [Term] id: GO:0051620 name: norepinephrine uptake namespace: biological_process def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "levarterenol reuptake" EXACT [] synonym: "levarterenol uptake" EXACT [] synonym: "noradrenaline reuptake" EXACT [] synonym: "noradrenaline uptake" EXACT [] synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "norepinephrine reuptake" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0051934 ! catecholamine uptake involved in synaptic transmission [Term] id: GO:0051621 name: regulation of norepinephrine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai] synonym: "regulation of levarterenol uptake" EXACT [] synonym: "regulation of noradrenaline uptake" EXACT [] synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission relationship: regulates GO:0051620 ! norepinephrine uptake [Term] id: GO:0051622 name: negative regulation of norepinephrine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "down regulation of norepinephrine uptake" EXACT [] synonym: "down-regulation of norepinephrine uptake" EXACT [] synonym: "downregulation of norepinephrine uptake" EXACT [] synonym: "negative regulation of levarterenol uptake" EXACT [] synonym: "negative regulation of noradrenaline uptake" EXACT [] synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051621 ! regulation of norepinephrine uptake is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission relationship: negatively_regulates GO:0051620 ! norepinephrine uptake [Term] id: GO:0051623 name: positive regulation of norepinephrine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "activation of norepinephrine uptake" NARROW [] synonym: "positive regulation of levarterenol uptake" EXACT [] synonym: "positive regulation of noradrenaline uptake" EXACT [] synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of norepinephrine uptake" NARROW [] synonym: "up regulation of norepinephrine uptake" EXACT [] synonym: "up-regulation of norepinephrine uptake" EXACT [] synonym: "upregulation of norepinephrine uptake" EXACT [] is_a: GO:0051621 ! regulation of norepinephrine uptake is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission relationship: positively_regulates GO:0051620 ! norepinephrine uptake [Term] id: GO:0051624 name: inhibition of norepinephrine uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "inhibition of levarterenol uptake" EXACT [] synonym: "inhibition of noradrenaline uptake" EXACT [] synonym: "inhibition of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051622 ! negative regulation of norepinephrine uptake [Term] id: GO:0051625 name: epinephrine uptake namespace: biological_process def: "The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] synonym: "adrenaline reuptake" EXACT [] synonym: "adrenaline uptake" EXACT [] synonym: "epinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "epinephrine reuptake" EXACT [] is_a: GO:0048241 ! epinephrine transport is_a: GO:0051934 ! catecholamine uptake involved in synaptic transmission [Term] id: GO:0051626 name: regulation of epinephrine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell." [GOC:ai] synonym: "regulation of adrenaline uptake" EXACT [] synonym: "regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission relationship: regulates GO:0051625 ! epinephrine uptake [Term] id: GO:0051627 name: negative regulation of epinephrine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai] synonym: "down regulation of epinephrine uptake" EXACT [] synonym: "down-regulation of epinephrine uptake" EXACT [] synonym: "downregulation of epinephrine uptake" EXACT [] synonym: "negative regulation of adrenaline uptake" EXACT [] synonym: "negative regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051626 ! regulation of epinephrine uptake is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission relationship: negatively_regulates GO:0051625 ! epinephrine uptake [Term] id: GO:0051628 name: positive regulation of epinephrine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai] synonym: "activation of epinephrine uptake" NARROW [] synonym: "positive regulation of adrenaline uptake" EXACT [] synonym: "positive regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of epinephrine uptake" NARROW [] synonym: "up regulation of epinephrine uptake" EXACT [] synonym: "up-regulation of epinephrine uptake" EXACT [] synonym: "upregulation of epinephrine uptake" EXACT [] is_a: GO:0051626 ! regulation of epinephrine uptake is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission relationship: positively_regulates GO:0051625 ! epinephrine uptake [Term] id: GO:0051629 name: inhibition of epinephrine uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of epinephrine into a cell." [GOC:ai] synonym: "inhibition of adrenaline uptake" EXACT [] synonym: "inhibition of epinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051627 ! negative regulation of epinephrine uptake [Term] id: GO:0051630 name: acetylcholine uptake namespace: biological_process def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai] synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0015870 ! acetylcholine transport [Term] id: GO:0051631 name: regulation of acetylcholine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai] synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051952 ! regulation of amine transport relationship: regulates GO:0051630 ! acetylcholine uptake [Term] id: GO:0051632 name: negative regulation of acetylcholine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "down regulation of acetylcholine uptake" EXACT [] synonym: "down-regulation of acetylcholine uptake" EXACT [] synonym: "downregulation of acetylcholine uptake" EXACT [] synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051953 ! negative regulation of amine transport relationship: negatively_regulates GO:0051630 ! acetylcholine uptake [Term] id: GO:0051633 name: positive regulation of acetylcholine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "activation of acetylcholine uptake" NARROW [] synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of acetylcholine uptake" NARROW [] synonym: "up regulation of acetylcholine uptake" EXACT [] synonym: "up-regulation of acetylcholine uptake" EXACT [] synonym: "upregulation of acetylcholine uptake" EXACT [] is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051954 ! positive regulation of amine transport relationship: positively_regulates GO:0051630 ! acetylcholine uptake [Term] id: GO:0051634 name: inhibition of acetylcholine uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "inhibition of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051632 ! negative regulation of acetylcholine uptake [Term] id: GO:0051635 name: bacterial cell surface binding namespace: molecular_function alt_id: GO:0008367 def: "Interacting selectively and non-covalently with any component on the surface of a bacterial cell." [GOC:ai] subset: gosubset_prok synonym: "bacterial binding" EXACT [] synonym: "bacterium binding" EXACT [] synonym: "bacterium cell surface binding" EXACT [] synonym: "binding to bacterium" EXACT [] is_a: GO:0043498 ! cell surface binding [Term] id: GO:0051636 name: Gram-negative bacterial cell surface binding namespace: molecular_function alt_id: GO:0008368 def: "Interacting selectively and non-covalently with any component on the surface of a Gram-negative bacterial cell." [GOC:ai] subset: gosubset_prok synonym: "binding to Gram-negative bacterium" EXACT [] synonym: "Gram-negative bacterial binding" EXACT [] synonym: "Gram-negative bacterium binding" EXACT [] synonym: "Gram-negative bacterium cell surface binding" EXACT [] is_a: GO:0051635 ! bacterial cell surface binding [Term] id: GO:0051637 name: Gram-positive bacterial cell surface binding namespace: molecular_function alt_id: GO:0051076 def: "Interacting selectively and non-covalently with any component on the surface of a Gram-positive bacterium." [GOC:ai] subset: gosubset_prok synonym: "binding to Gram-positive bacterium" EXACT [] synonym: "Gram-positive bacterial binding" EXACT [] synonym: "Gram-positive bacterium binding" EXACT [] synonym: "Gram-positive bacterium cell surface binding" EXACT [] is_a: GO:0051635 ! bacterial cell surface binding [Term] id: GO:0051638 name: barbed-end actin filament uncapping namespace: biological_process def: "The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] synonym: "barbed end actin filament uncapping" EXACT [] synonym: "barbed end F-actin uncapping" EXACT [] synonym: "barbed-end F-actin uncapping" EXACT [] synonym: "plus end actin filament uncapping" EXACT [] synonym: "plus end F-actin uncapping" EXACT [] synonym: "plus-end actin filament uncapping" EXACT [] synonym: "plus-end F-actin uncapping" EXACT [] is_a: GO:0051695 ! actin filament uncapping [Term] id: GO:0051639 name: actin filament network formation namespace: biological_process def: "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai] synonym: "actin gel biosynthesis" EXACT [] synonym: "actin gel formation" EXACT [] is_a: GO:0007015 ! actin filament organization [Term] id: GO:0051640 name: organelle localization namespace: biological_process def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] subset: goslim_pir synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization [Term] id: GO:0051641 name: cellular localization namespace: biological_process def: "A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell." [GOC:ai, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "cellular localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular localization" EXACT [] synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] synonym: "intracellular localization" NARROW [] synonym: "localization within cell" NARROW [] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization [Term] id: GO:0051642 name: centrosome localization namespace: biological_process def: "Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "centrosome localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of centrosome localization" EXACT [] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051643 name: endoplasmic reticulum localization namespace: biological_process def: "Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "endoplasmic reticulum localisation" EXACT [GOC:mah] synonym: "ER localization" EXACT [GOC:dph] synonym: "establishment and maintenance of ER localization" EXACT [] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051644 name: plastid localization namespace: biological_process def: "Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of plastid localization" EXACT [] synonym: "plastid localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051645 name: Golgi localization namespace: biological_process def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of Golgi localization" EXACT [] synonym: "Golgi apparatus localization" EXACT [] synonym: "Golgi body localization" EXACT [] synonym: "Golgi localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051646 name: mitochondrion localization namespace: biological_process def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of mitochondria localization" EXACT [] synonym: "establishment and maintenance of mitochondrion localization" EXACT [] synonym: "localization of mitochondria" EXACT [] synonym: "localization of mitochondrion" EXACT [] synonym: "mitochondria localization" EXACT [] synonym: "mitochondrial localization" EXACT [] synonym: "mitochondrion localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051647 name: nucleus localization namespace: biological_process def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "cell nucleus localization" EXACT [] synonym: "establishment and maintenance of nucleus localization" EXACT [] synonym: "localization of nucleus" EXACT [] synonym: "nucleus localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051648 name: vesicle localization namespace: biological_process def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cytoplasmic vesicle localization" EXACT [] synonym: "establishment and maintenance of vesicle localization" EXACT [] synonym: "vesicle localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051649 name: establishment of localization in cell namespace: biological_process def: "The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "establishment of intracellular localization" NARROW [] synonym: "establishment of localisation in cell" EXACT [GOC:mah] synonym: "establishment of localization within cell" NARROW [] synonym: "positioning within cell" NARROW [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0051641 ! cellular localization [Term] id: GO:0051650 name: establishment of vesicle localization namespace: biological_process def: "The directed movement of a vesicle to a specific location." [GOC:ai] synonym: "establishment of vesicle localisation" EXACT [GOC:mah] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0051648 ! vesicle localization [Term] id: GO:0051651 name: maintenance of location in cell namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai] subset: gosubset_prok synonym: "cellular retention" NARROW [] synonym: "cellular sequestering" NARROW [] synonym: "cellular storage" NARROW [] synonym: "intracellular retention" NARROW [] synonym: "intracellular sequestering" NARROW [] synonym: "intracellular storage" NARROW [] synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of intracellular localization" NARROW [] synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of localization within cell" NARROW [] synonym: "retention within cell" NARROW [] synonym: "sequestering within cell" NARROW [] synonym: "storage within cell" NARROW [] is_a: GO:0009987 ! cellular process is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0051641 ! cellular localization [Term] id: GO:0051652 name: maintenance of chromosome location namespace: biological_process def: "Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of chromosome localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0050000 ! chromosome localization [Term] id: GO:0051653 name: spindle localization namespace: biological_process def: "Any process in which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of spindle localization" EXACT [] synonym: "spindle localisation" EXACT [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0051640 ! organelle localization [Term] id: GO:0051654 name: establishment of mitochondrion localization namespace: biological_process def: "The directed movement of the mitochondrion to a specific location." [GOC:ai] synonym: "establishment of mitochondria localization" EXACT [] synonym: "establishment of mitochondrion localisation" EXACT [GOC:mah] synonym: "mitochondria positioning" EXACT [] synonym: "mitochondrial migration" EXACT [] synonym: "mitochondrion positioning" EXACT [] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0051646 ! mitochondrion localization [Term] id: GO:0051655 name: maintenance of vesicle location namespace: biological_process def: "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0051648 ! vesicle localization [Term] id: GO:0051656 name: establishment of organelle localization namespace: biological_process def: "The directed movement of an organelle to a specific location." [GOC:ai] synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0051640 ! organelle localization [Term] id: GO:0051657 name: maintenance of organelle location namespace: biological_process def: "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051651 ! maintenance of location in cell relationship: part_of GO:0051640 ! organelle localization [Term] id: GO:0051658 name: maintenance of nucleus location namespace: biological_process def: "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of cell nucleus location" EXACT [] synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0051647 ! nucleus localization [Term] id: GO:0051659 name: maintenance of mitochondrion location namespace: biological_process def: "Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of mitochondria localization" EXACT [] synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0051646 ! mitochondrion localization [Term] id: GO:0051660 name: establishment of centrosome localization namespace: biological_process def: "The directed movement of the centrosome to a specific location." [GOC:ai] synonym: "centrosome positioning" EXACT [] synonym: "establishment of centrosome localisation" EXACT [GOC:mah] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0051642 ! centrosome localization [Term] id: GO:0051661 name: maintenance of centrosome location namespace: biological_process def: "Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of centrosome localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0051642 ! centrosome localization [Term] id: GO:0051663 name: oocyte nucleus localization involved in oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0051662 def: "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb] synonym: "establishment and maintenance of oocyte nucleus localization during oocyte axis determination" EXACT [] synonym: "oocyte axis determination, oocyte nucleus localization" EXACT [] synonym: "oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "oocyte nucleus localization during oocyte axis determination" RELATED [GOC:dph, GOC:tb] synonym: "oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] synonym: "oocyte nucleus localization involved in oocyte dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051647 ! nucleus localization relationship: part_of GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0051664 name: nuclear pore localization namespace: biological_process def: "Any process in which nuclear pores are transported to, or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of nuclear pore localization" EXACT [] synonym: "nuclear pore localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization is_a: GO:0051668 ! localization within membrane [Term] id: GO:0051665 name: membrane raft localization namespace: biological_process def: "Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:ai, PMID:16645198] synonym: "establishment and maintenance of membrane raft localization" EXACT [] synonym: "lipid raft localization" EXACT [] synonym: "membrane raft localisation" EXACT [GOC:mah] is_a: GO:0051668 ! localization within membrane [Term] id: GO:0051666 name: actin cortical patch localization namespace: biological_process def: "Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:mah] synonym: "actin cortical patch localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of actin cortical patch localization" EXACT [] is_a: GO:0051641 ! cellular localization [Term] id: GO:0051667 name: establishment of plastid localization namespace: biological_process def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai] synonym: "establishment of plastid localisation" EXACT [GOC:mah] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0051644 ! plastid localization [Term] id: GO:0051668 name: localization within membrane namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] subset: gosubset_prok synonym: "establishment and maintenance of localization in membrane" EXACT [] synonym: "establishment and maintenance of position in membrane" EXACT [] synonym: "localisation within membrane" EXACT [GOC:mah] synonym: "localization to membrane" EXACT [] synonym: "positioning within membrane" NARROW [] is_a: GO:0051641 ! cellular localization [Term] id: GO:0051669 name: fructan beta-fructosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.80] synonym: "beta-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.80] synonym: "exo-beta-D-fructosidase activity" EXACT [] synonym: "exo-beta-fructosidase activity" EXACT [] synonym: "fructan b-fructosidase activity" EXACT [] synonym: "fructan exohydrolase activity" EXACT [] synonym: "fructanase activity" EXACT [EC:3.2.1.80] synonym: "polysaccharide beta-fructofuranosidase activity" EXACT [] xref: EC:3.2.1.80 xref: MetaCyc:3.2.1.80-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0051670 name: inulinase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin." [EC:3.2.1.7] synonym: "2,1-beta-D-fructan fructanohydrolase activity" EXACT [] synonym: "endo-inulinase activity" EXACT [] synonym: "exoinulinase activity" EXACT [] synonym: "indoinulinase activity" EXACT [] synonym: "inulase activity" EXACT [] xref: EC:3.2.1.7 xref: MetaCyc:3.2.1.7-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0051671 name: induction of autolysin activity in other organism namespace: biological_process def: "Any process in which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism." [GOC:ai] subset: gosubset_prok synonym: "activation of autolysin activity in another organism" EXACT [] synonym: "activation of autolysis in other organism" NARROW [] synonym: "activation of autolytic activity in other organism" NARROW [] synonym: "induction of autolysin activity in another organism" EXACT [GOC:bf] synonym: "induction of autolysis in other organism" NARROW [] synonym: "induction of autolytic activity in other organism" NARROW [] synonym: "positive regulation of autolysin activity in another organism" BROAD [] is_a: GO:0043946 ! positive regulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0051672 name: catabolism by organism of cell wall peptidoglycan in other organism namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the cell wall peptidoglycans of another organism." [GOC:ai] subset: gosubset_prok synonym: "catabolic process of cell wall peptidoglycans of other organism" EXACT [] synonym: "catabolism of cell wall peptidoglycans of other organism" EXACT [] synonym: "cell wall catabolic process in other organism" NARROW [] synonym: "cell wall catabolism in other organism" NARROW [] synonym: "cell wall peptidoglycan catabolic process in another organism" EXACT [] is_a: GO:0009253 ! peptidoglycan catabolic process is_a: GO:0070910 ! cell wall macromolecule catabolic process involved in cell wall disassembly relationship: part_of GO:0009617 ! response to bacterium relationship: part_of GO:0044278 ! cell wall disassembly in other organism [Term] id: GO:0051673 name: membrane disruption in other organism namespace: biological_process def: "The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism." [GOC:ai] subset: gosubset_prok synonym: "cytolysis, by membrane disruption, in other organism" NARROW [] synonym: "membrane disruption in another organism" EXACT [GOC:bf] is_a: GO:0051704 ! multi-organism process [Term] id: GO:0051674 name: localization of cell namespace: biological_process def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] subset: gosubset_prok synonym: "cell localization" EXACT [] synonym: "establishment and maintenance of cell localization" EXACT [] synonym: "establishment and maintenance of localization of cell" EXACT [] synonym: "localisation of cell" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0051675 name: isopullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)." [EC:3.2.1.57] synonym: "pullulan 4-glucanohydrolase (isopanose-forming) activity" EXACT [] xref: EC:3.2.1.57 xref: MetaCyc:3.2.1.57-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0051676 name: pullulan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [PMID:15013381] synonym: "pullulan metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0051677 name: pullulan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0051676 ! pullulan metabolic process [Term] id: GO:0051678 name: pullulan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0051676 ! pullulan metabolic process [Term] id: GO:0051679 name: 6-alpha-maltosylglucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai, LIGAND:C03367, PubChem_Compound:439991] synonym: "6-alpha-maltosylglucose metabolism" EXACT [] synonym: "isopanose metabolic process" EXACT [] synonym: "isopanose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0051680 name: 6-alpha-maltosylglucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai] synonym: "isopanose biosynthesis" EXACT [] synonym: "isopanose biosynthetic process" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process [Term] id: GO:0051681 name: 6-alpha-maltosylglucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai] synonym: "isopanose catabolic process" EXACT [] synonym: "isopanose catabolism" EXACT [] is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process [Term] id: GO:0051682 name: galactomannan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai] is_a: GO:0046355 ! mannan catabolic process is_a: GO:0051069 ! galactomannan metabolic process [Term] id: GO:0051683 name: establishment of Golgi localization namespace: biological_process def: "The directed movement of the Golgi to a specific location." [GOC:ai] synonym: "establishment of Golgi apparatus localization" EXACT [] synonym: "establishment of Golgi body localization" EXACT [] synonym: "establishment of Golgi localisation" EXACT [GOC:mah] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0051645 ! Golgi localization [Term] id: GO:0051684 name: maintenance of Golgi location namespace: biological_process def: "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of Golgi apparatus localization" EXACT [] synonym: "maintenance of Golgi body localization" EXACT [] synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0051645 ! Golgi localization [Term] id: GO:0051685 name: maintenance of ER location namespace: biological_process def: "Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of endoplasmic reticulum localization" EXACT [] synonym: "maintenance of ER localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0051643 ! endoplasmic reticulum localization [Term] id: GO:0051686 name: establishment of ER localization namespace: biological_process def: "The directed movement of the endoplasmic reticulum to a specific location." [GOC:ai] synonym: "establishment of endoplasmic reticulum localization" EXACT [] synonym: "establishment of ER localisation" EXACT [GOC:mah] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization relationship: part_of GO:0051643 ! endoplasmic reticulum localization [Term] id: GO:0051687 name: maintenance of spindle location namespace: biological_process def: "Any process in which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of spindle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0051653 ! spindle localization [Term] id: GO:0051688 name: maintenance of plastid location namespace: biological_process def: "Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0051644 ! plastid localization [Term] id: GO:0051689 name: multicellular organismal oligosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:ai] synonym: "organismal oligosaccharide breakdown" EXACT [] synonym: "organismal oligosaccharide catabolism" EXACT [] synonym: "organismal oligosaccharide degradation" EXACT [] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:0044276 ! multicellular organismal carbohydrate catabolic process is_a: GO:0051690 ! multicellular organismal oligosaccharide metabolic process [Term] id: GO:0051690 name: multicellular organismal oligosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:ai] synonym: "organismal oligosaccharide metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044261 ! multicellular organismal carbohydrate metabolic process [Term] id: GO:0051691 name: cellular oligosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai] synonym: "cellular oligosaccharide metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0051692 name: cellular oligosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai] synonym: "cellular oligosaccharide breakdown" EXACT [] synonym: "cellular oligosaccharide catabolism" EXACT [] synonym: "cellular oligosaccharide degradation" EXACT [] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0051691 ! cellular oligosaccharide metabolic process [Term] id: GO:0051693 name: actin filament capping namespace: biological_process def: "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] synonym: "actin capping activity" RELATED [] synonym: "F-actin capping activity" RELATED [] is_a: GO:0030835 ! negative regulation of actin filament depolymerization is_a: GO:0030837 ! negative regulation of actin filament polymerization [Term] id: GO:0051694 name: pointed-end actin filament capping namespace: biological_process def: "The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] synonym: "minus-end actin filament capping activity" EXACT [] synonym: "minus-end F-actin capping activity" EXACT [] synonym: "pointed-end actin capping activity" EXACT [] synonym: "pointed-end F-actin capping activity" EXACT [] is_a: GO:0051693 ! actin filament capping [Term] id: GO:0051695 name: actin filament uncapping namespace: biological_process def: "The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] synonym: "F-actin uncapping" EXACT [] is_a: GO:0030836 ! positive regulation of actin filament depolymerization [Term] id: GO:0051696 name: pointed-end actin filament uncapping namespace: biological_process def: "The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] synonym: "minus end actin filament uncapping" EXACT [] synonym: "minus end F-actin uncapping" EXACT [] synonym: "minus-end actin filament uncapping" EXACT [] synonym: "minus-end F-actin uncapping" EXACT [] synonym: "pointed end actin filament uncapping" EXACT [] synonym: "pointed end F-actin uncapping" EXACT [] synonym: "pointed-end F-actin uncapping" EXACT [] is_a: GO:0051695 ! actin filament uncapping [Term] id: GO:0051697 name: protein delipidation namespace: biological_process def: "The breakage of covalent bonds to detach lipid groups from a protein." [GOC:ai] is_a: GO:0006464 ! protein modification process [Term] id: GO:0051698 name: saccharopine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2." [PMID:16233628] synonym: "SAX activity" BROAD [] is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0051699 name: proline oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [MetaCyc:RXN-821] xref: EC:1.5.3.- xref: MetaCyc:RXN-821 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0051700 name: fructosyl-amino acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2." [PMID:16233628] synonym: "FAOD activity" EXACT [] xref: EC:1.5.3.- is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0051701 name: interaction with host namespace: biological_process def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] subset: gosubset_prok is_a: GO:0044419 ! interspecies interaction between organisms relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0051702 name: interaction with symbiont namespace: biological_process def: "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] subset: gosubset_prok is_a: GO:0044419 ! interspecies interaction between organisms relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0051703 name: intraspecies interaction between organisms namespace: biological_process def: "Any process in which an organism has an effect on an organism of the same species." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "intraspecies interaction with other organisms" EXACT [] is_a: GO:0051704 ! multi-organism process [Term] id: GO:0051704 name: multi-organism process namespace: biological_process alt_id: GO:0051706 def: "Any process in which an organism has an effect on another organism of the same or different species." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "interaction between organisms" EXACT [] synonym: "physiological interaction between organisms" EXACT [] synonym: "physiological interaction with other organism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0051705 name: behavioral interaction between organisms namespace: biological_process alt_id: GO:0023032 def: "Any process in which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai] subset: goslim_pir synonym: "behavioral interaction with other organism" EXACT [] synonym: "behavioral signaling" NARROW [] synonym: "behavioral signalling" NARROW [GOC:mah] synonym: "behavioural interaction between organisms" EXACT [] synonym: "behavioural interaction with other organism" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0051704 ! multi-organism process [Term] id: GO:0051707 name: response to other organism namespace: biological_process alt_id: GO:0009613 alt_id: GO:0042828 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] subset: gosubset_prok is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051704 ! multi-organism process [Term] id: GO:0051708 name: intracellular protein transport in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of an organism's proteins within a cell of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "intracellular protein transport in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0006886 ! intracellular protein transport relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0051709 name: regulation of killing of cells of other organism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] subset: gosubset_prok synonym: "regulation of killing of cells of another organism" EXACT [GOC:bf] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0031640 ! killing of cells of other organism [Term] id: GO:0051710 name: regulation of cytolysis in other organism namespace: biological_process alt_id: GO:0001902 def: "Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai] subset: gosubset_prok synonym: "regulation of cytolysis of cells of another organism" EXACT [GOC:bf] synonym: "regulation of cytolysis of cells of another, non-host, organism" NARROW [] is_a: GO:0051709 ! regulation of killing of cells of other organism relationship: regulates GO:0051715 ! cytolysis in other organism [Term] id: GO:0051711 name: negative regulation of killing of cells of other organism namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] subset: gosubset_prok synonym: "down regulation of killing of cells of another organism" EXACT [] synonym: "down-regulation of killing of cells of another organism" EXACT [] synonym: "downregulation of killing of cells of another organism" EXACT [] synonym: "inhibition of killing of cells of another organism" NARROW [] synonym: "negative regulation of killing of cells of another organism" EXACT [GOC:bf] is_a: GO:0031342 ! negative regulation of cell killing is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051709 ! regulation of killing of cells of other organism relationship: negatively_regulates GO:0031640 ! killing of cells of other organism [Term] id: GO:0051712 name: positive regulation of killing of cells of other organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] subset: gosubset_prok synonym: "activation of killing of cells of another organism" NARROW [] synonym: "positive regulation of killing of cells of other organism" EXACT [GOC:bf] synonym: "stimulation of killing of cells of another organism" NARROW [] synonym: "up regulation of killing of cells of another organism" EXACT [] synonym: "up-regulation of killing of cells of another organism" EXACT [] synonym: "upregulation of killing of cells of another organism" EXACT [] is_a: GO:0031343 ! positive regulation of cell killing is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051709 ! regulation of killing of cells of other organism relationship: positively_regulates GO:0031640 ! killing of cells of other organism [Term] id: GO:0051713 name: negative regulation of cytolysis in other organism namespace: biological_process alt_id: GO:0001903 def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cytolysis of cells in another organism." [GOC:ai] subset: gosubset_prok synonym: "down regulation of cytolysis of cells of another organism" EXACT [] synonym: "down-regulation of cytolysis of cells of another organism" EXACT [] synonym: "downregulation of cytolysis of cells of another organism" EXACT [] synonym: "inhibition of cytolysis of cells of another organism" NARROW [] synonym: "negative regulation of cytolysis of cells of another organism" EXACT [GOC:bf] synonym: "negative regulation of cytolysis of cells of another, non-host, organism" NARROW [] is_a: GO:0051710 ! regulation of cytolysis in other organism is_a: GO:0051711 ! negative regulation of killing of cells of other organism relationship: negatively_regulates GO:0051715 ! cytolysis in other organism [Term] id: GO:0051714 name: positive regulation of cytolysis in other organism namespace: biological_process alt_id: GO:0001904 def: "Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai] subset: gosubset_prok synonym: "activation of cytolysis of cells of another organism" NARROW [] synonym: "positive regulation of cytolysis of cells of another organism" EXACT [GOC:bf] synonym: "positive regulation of cytolysis of cells of another, non-host, organism" NARROW [] synonym: "stimulation of cytolysis of cells of another organism" NARROW [] synonym: "up regulation of cytolysis of cells of another organism" EXACT [] synonym: "up-regulation of cytolysis of cells of another organism" EXACT [] synonym: "upregulation of cytolysis of cells of another organism" EXACT [] is_a: GO:0051710 ! regulation of cytolysis in other organism is_a: GO:0051712 ! positive regulation of killing of cells of other organism relationship: positively_regulates GO:0051715 ! cytolysis in other organism [Term] id: GO:0051715 name: cytolysis in other organism namespace: biological_process alt_id: GO:0001901 def: "The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:ai] subset: gosubset_prok synonym: "cytolysis of cells of another organism" EXACT [GOC:bf] synonym: "cytolysis of cells of another, non-host, organism" NARROW [] synonym: "cytolysis of cells of competing organism" NARROW [] is_a: GO:0031640 ! killing of cells of other organism [Term] id: GO:0051716 name: cellular response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC. subset: gosubset_prok subset: high_level_annotation_qc is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051717 name: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:bf, MetaCyc:3.1.3.62-RXN] synonym: "inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity" EXACT [EC:2.7.1.-] synonym: "inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity" EXACT [EC:2.7.1.-] synonym: "inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity" EXACT [EC:2.7.1.-] xref: MetaCyc:3.1.3.62-RXN is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0051718 name: DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA)." [EC:2.1.1.37, PMID:15689527] synonym: "HpaII methylase" NARROW [EC:2.1.1.37] synonym: "HpaII' methylase" NARROW [EC:2.1.1.37] synonym: "M.BsuRIa" NARROW [EC:2.1.1.37] synonym: "M.BsuRIb" NARROW [EC:2.1.1.37] is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity [Term] id: GO:0051719 name: DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN." [EC:2.1.1.37, PMID:15689527] is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity [Term] id: GO:0051720 name: DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG." [EC:2.1.1.37, PMID:15689527] is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity [Term] id: GO:0051721 name: protein phosphatase 2A binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 2A." [GOC:ai] is_a: GO:0019903 ! protein phosphatase binding [Term] id: GO:0051722 name: protein C-terminal methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol." [PMID:10318862, PMID:8650216] synonym: "protein phosphatase methylesterase activity" NARROW [] is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0051723 name: protein methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol." [GOC:ai] subset: gosubset_prok synonym: "PME activity" EXACT [EC:2.7.1.-] synonym: "protein carboxyl methylesterase activity" EXACT [EC:2.7.1.-] synonym: "protein carboxylic ester hydrolase activity" EXACT [] synonym: "protein methyl-esterase activity" EXACT [EC:2.7.1.-] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0051724 name: NAD transporter activity namespace: molecular_function def: "Enables the directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:ai] synonym: "NAD (oxidized) transporter activity" EXACT [] synonym: "NAD (reduced) transporter activity" EXACT [] synonym: "NAD+ transporter activity" EXACT [] synonym: "NADH transporter activity" EXACT [] synonym: "nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "oxidized NAD transporter activity" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "reduced NAD transporter activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0051725 name: protein de-ADP-ribosylation namespace: biological_process def: "The process of removing one or more ADP-ribose residues from a protein." [GOC:ai] synonym: "poly(ADP-ribose) removal from protein" EXACT [] synonym: "protein amino acid de-ADP-ribosylation" EXACT [GOC:bf] synonym: "protein poly(ADP-ribose) catabolic process" EXACT [] synonym: "protein poly(ADP-ribose) catabolism" EXACT [] synonym: "protein poly(ADP-ribose) degradation" EXACT [] synonym: "protein poly(ADP-ribose) hydrolysis" EXACT [] synonym: "removal of ADP-ribose from protein" EXACT [] is_a: GO:0006464 ! protein modification process [Term] id: GO:0051726 name: regulation of cell cycle namespace: biological_process alt_id: GO:0000074 def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "cell cycle control" EXACT [] synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] xref: Reactome:1232389 "Activation of Cdc25C" xref: Reactome:1232399 "Inactivation of Wee1 kinase" xref: Reactome:1232986 "Inactivation of Myt1 kinase" xref: Reactome:1253277 "Polo-like kinase mediated events" xref: Reactome:1260069 "Activation of Cdc25C" xref: Reactome:1260082 "Inactivation of Wee1 kinase" xref: Reactome:1260690 "Inactivation of Myt1 kinase" xref: Reactome:1280213 "Polo-like kinase mediated events" xref: Reactome:1306028 "Activation of Cdc25C" xref: Reactome:1306038 "Inactivation of Wee1 kinase" xref: Reactome:1306605 "Inactivation of Myt1 kinase" xref: Reactome:1326789 "Polo-like kinase mediated events" xref: Reactome:1333585 "Activation of Cdc25C" xref: Reactome:1333595 "Inactivation of Wee1 kinase" xref: Reactome:1334123 "Inactivation of Myt1 kinase" xref: Reactome:1352892 "Polo-like kinase mediated events" xref: Reactome:1357948 "Inactivation of Wee1 kinase" xref: Reactome:1373098 "Polo-like kinase mediated events" xref: Reactome:1379040 "Inactivation of Wee1 kinase" xref: Reactome:1393114 "Polo-like kinase mediated events" xref: Reactome:1399527 "Activation of Cdc25C" xref: Reactome:1399537 "Inactivation of Wee1 kinase" xref: Reactome:1400015 "Inactivation of Myt1 kinase" xref: Reactome:1417600 "Polo-like kinase mediated events" xref: Reactome:1426514 "Activation of Cdc25C" xref: Reactome:1427435 "Inactivation of Myt1 kinase" xref: Reactome:1450691 "Polo-like kinase mediated events" xref: Reactome:1457247 "Activation of Cdc25C" xref: Reactome:1457258 "Inactivation of Wee1 kinase" xref: Reactome:1457562 "Inactivation of Myt1 kinase" xref: Reactome:1471155 "Polo-like kinase mediated events" xref: Reactome:1475837 "Inactivation of Myt1 kinase" xref: Reactome:1483166 "Polo-like kinase mediated events" xref: Reactome:1517493 "Activation of Cdc25C" xref: Reactome:1517583 "Inactivation of Myt1 kinase" xref: Reactome:1521107 "Polo-like kinase mediated events" xref: Reactome:1524306 "Inactivation of Myt1 kinase" xref: Reactome:1526878 "Polo-like kinase mediated events" xref: Reactome:1530125 "Inactivation of Myt1 kinase" xref: Reactome:1532608 "Polo-like kinase mediated events" xref: Reactome:156678 "Activation of Cdc25C" xref: Reactome:156699 "Inactivation of Wee1 kinase" xref: Reactome:156711 "Polo-like kinase mediated events" xref: Reactome:162657 "Inactivation of Myt1 kinase" is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007049 ! cell cycle [Term] id: GO:0051727 name: cell cycle switching, meiotic to mitotic cell cycle namespace: biological_process def: "The process in which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai] synonym: "cell cycle switching, meiosis to mitosis" NARROW [] synonym: "conversion to mitosis" NARROW [] synonym: "conversion to mitotic cell cycle" EXACT [] synonym: "entry into mitosis" NARROW [] synonym: "entry into mitotic cell cycle" EXACT [] synonym: "initiation of mitosis" NARROW [] synonym: "initiation of mitotic cell cycle" EXACT [] synonym: "mitotic entry" NARROW [] is_a: GO:0060184 ! cell cycle switching [Term] id: GO:0051728 name: cell cycle switching, mitotic to meiotic cell cycle namespace: biological_process alt_id: GO:0042061 def: "The process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai] synonym: "cell cycle switching, mitotis to meiosis" NARROW [] synonym: "conversion to meiosis" NARROW [] synonym: "conversion to meiotic cell cycle" EXACT [] synonym: "entry into meiosis" NARROW [] synonym: "entry into meiotic cell cycle" EXACT [] synonym: "initiation of meiosis" NARROW [] synonym: "initiation of meiotic cell cycle" EXACT [] synonym: "meiotic entry" NARROW [] is_a: GO:0060184 ! cell cycle switching [Term] id: GO:0051729 name: germline cell cycle switching, mitotic to meiotic cell cycle namespace: biological_process def: "The process in which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai] synonym: "germline cell cycle switching, mitotis to meiosis" NARROW [] synonym: "germline conversion to meiosis" NARROW [] synonym: "germline conversion to meiotic cell cycle" EXACT [] synonym: "germline entry into meiosis" NARROW [] synonym: "germline entry into meiotic cell cycle" EXACT [] synonym: "germline initiation of meiosis" NARROW [] synonym: "germline initiation of meiotic cell cycle" EXACT [] synonym: "germline meiotic entry" NARROW [] is_a: GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle [Term] id: GO:0051730 name: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA." [EC:2.7.1.78, PMID:8428918] synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "GTP-dependent polyribonucleotide kinase activity" EXACT [] synonym: "GTP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "GTP-dependent RNA kinase activity" EXACT [] synonym: "GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] is_a: GO:0051732 ! polyribonucleotide kinase activity is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity [Term] id: GO:0051731 name: polynucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] synonym: "5'-dephosphopolynucleotide kinase activity" EXACT [] synonym: "5'-hydroxyl polynucleotide kinase activity" EXACT [EC:2.7.1.78] synonym: "PNK" RELATED [EC:2.7.1.78] synonym: "polynucleotide 5'-hydroxy-kinase activity" EXACT [EC:2.7.1.78] synonym: "polynucleotide 5'-hydroxyl kinase (phosphorylating) activity" EXACT [EC:2.7.1.78] synonym: "polynucleotide kinase activity" BROAD [EC:2.7.1.78] xref: EC:2.7.1.- is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity [Term] id: GO:0051732 name: polyribonucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA." [EC:2.7.1.78] synonym: "5'-hydroxyl polyribonucleotide kinase activity" EXACT [EC:2.7.1.78] synonym: "5'-hydroxyl RNA kinase activity" EXACT [EC:2.7.1.78] synonym: "RNA 5'-hydroxyl kinase activity" EXACT [] synonym: "RNA kinase activity" EXACT [] is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity [Term] id: GO:0051733 name: polydeoxyribonucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA." [EC:2.7.1.78] synonym: "DNA 5'-hydroxyl kinase activity" EXACT [] synonym: "DNA kinase activity" EXACT [] is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity [Term] id: GO:0051734 name: ATP-dependent polynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphatase activity" EXACT [EC:2.7.1.78] synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] xref: EC:2.7.1.- is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity [Term] id: GO:0051735 name: GTP-dependent polynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] synonym: "GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] xref: EC:2.7.1.- is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity [Term] id: GO:0051736 name: ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA." [EC:2.7.1.78] synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "ATP-dependent polyribonucleotide kinase activity" EXACT [] synonym: "ATP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP-dependent RNA kinase activity" EXACT [] synonym: "ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] is_a: GO:0051732 ! polyribonucleotide kinase activity is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity [Term] id: GO:0051737 name: GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA." [EC:2.7.1.78, PMID:8428918] synonym: "GTP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "GTP-dependent DNA kinase activity" EXACT [] synonym: "GTP-dependent polydeoxyribonucleotide kinase activity" EXACT [] synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity [Term] id: GO:0051738 name: xanthophyll binding namespace: molecular_function def: "Interacting selectively and non-covalently with xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen." [ISBN:0122146743] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0031409 ! pigment binding [Term] id: GO:0051739 name: ammonia transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of ammonia from one side of the membrane to the other." [GOC:go_curators] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0051740 name: ethylene binding namespace: molecular_function def: "Interacting selectively and non-covalently with ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai] synonym: "ethene binding" EXACT [] is_a: GO:0072328 ! alkene binding [Term] id: GO:0051741 name: 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542] synonym: "MPBQ methyltransferase activity" EXACT [] xref: MetaCyc:RXN-2542 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0051742 name: 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762] synonym: "MSBQ methyltransferase activity" EXACT [] xref: MetaCyc:RXN-2762 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0051743 name: red chlorophyll catabolite reductase activity namespace: molecular_function def: "Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence." [PMID:10743659] synonym: "RCC reductase activity" EXACT [] xref: EC:1.3.7.- xref: MetaCyc:RXN-7741 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0051744 name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity namespace: molecular_function def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72] xref: MetaCyc:RXN1F-72 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0051745 name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.1.2] synonym: "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity" EXACT [EC:1.17.1.2] synonym: "isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity" EXACT [] xref: EC:1.17.1.2 xref: MetaCyc:ISPH2-RXN is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0051746 name: thalianol synthase activity namespace: molecular_function def: "Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)." [PMID:15125655] is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0051747 name: cytosine C-5 DNA demethylase activity namespace: molecular_function def: "Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA." [PMID:10050851] synonym: "DNA demethylase activity" BROAD [PMID:10050851] synonym: "DNA methyltransferase activity acting on cytosine C-5" EXACT [] synonym: "hydrolytic DNA demethylase activity" BROAD [] is_a: GO:0016787 ! hydrolase activity is_a: GO:0035514 ! DNA demethylase activity [Term] id: GO:0051748 name: UTP-monosaccharide-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166] subset: gosubset_prok synonym: "PsUSP" RELATED [EC:2.7.7.64] synonym: "UDP-monosaccharide diphosphorylase activity" EXACT [] synonym: "UDP-monosaccharide pyrophosphorylase activity" EXACT [] synonym: "UDP-sugar pyrophosphorylase activity" EXACT [EC:2.7.7.64] synonym: "USP" RELATED [EC:2.7.7.64] xref: EC:2.7.7.64 xref: MetaCyc:2.7.7.64-RXN is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0051749 name: indole acetic acid carboxyl methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine." [PMID:16169896] synonym: "IAA carboxyl methyltransferase activity" EXACT [] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0051750 name: delta3,5-delta2,4-dienoyl-CoA isomerase activity namespace: molecular_function def: "Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA." [PMID:16040662] is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0051751 name: alpha-1,4-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,4-linkage." [PMID:15772281] is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0051752 name: phosphoglucan, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate." [EC:2.7.9.5, PMID:15618411] synonym: "ATP:phospho-alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.5] synonym: "OK1" RELATED [EC:2.7.9.5] synonym: "PWD" RELATED [EC:2.7.9.5] xref: EC:2.7.9.5 xref: MetaCyc:2.7.9.5-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0051753 name: mannan synthase activity namespace: molecular_function def: "Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-1,4-linked mannan backbone in substrates such as galactomannan." [PMID:14726589] synonym: "galactomannan beta-1,4-mannosyltransferase activity" NARROW [] synonym: "mannan beta-1,4-mannosyltransferase activity" EXACT [] is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity [Term] id: GO:0051754 name: meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "The cell cycle process in which centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576] synonym: "centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf] synonym: "meiotic sister chromatid cohesion at centromere" EXACT [] synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT [] is_a: GO:0070601 ! centromeric sister chromatid cohesion relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion [Term] id: GO:0051755 name: meiotic sister chromatid arm separation namespace: biological_process def: "The cell cycle process in which sister chromatid arms are physically detached from each other during meiosis." [GOC:ai] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I relationship: part_of GO:0051757 ! meiotic sister chromatid separation [Term] id: GO:0051756 name: meiotic sister chromatid centromere separation namespace: biological_process def: "The cell cycle process in which the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] is_a: GO:0034510 ! centromere separation relationship: part_of GO:0045144 ! meiotic sister chromatid segregation relationship: part_of GO:0051757 ! meiotic sister chromatid separation [Term] id: GO:0051757 name: meiotic sister chromatid separation namespace: biological_process def: "The process in which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] synonym: "meiotic sister chromatid resolution" EXACT [GOC:mah] is_a: GO:0051307 ! meiotic chromosome separation [Term] id: GO:0051758 name: homologous chromosome movement towards spindle pole involved in homologous chromosome segregation namespace: biological_process def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, that contributes to meiosis I." [GOC:ai] synonym: "homologous chromosome movement towards spindle pole during meiosis I" RELATED [GOC:dph, GOC:tb] synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT [] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole relationship: part_of GO:0045143 ! homologous chromosome segregation [Term] id: GO:0051759 name: sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation namespace: biological_process def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai] synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT [] synonym: "sister chromosome movement towards spindle pole during meiosis II" RELATED [GOC:dph, GOC:tb] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole relationship: part_of GO:0045144 ! meiotic sister chromatid segregation [Term] id: GO:0051760 name: meiotic sister chromatid cohesion, arms namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576] synonym: "meiotic sister chromatid cohesion along arms" EXACT [] synonym: "sister chromatid cohesion along arms at meiosis I" EXACT [] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion [Term] id: GO:0051761 name: sesquiterpene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] subset: gosubset_prok synonym: "sesquiterpene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0051762 name: sesquiterpene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] subset: gosubset_prok is_a: GO:0046246 ! terpene biosynthetic process is_a: GO:0051761 ! sesquiterpene metabolic process [Term] id: GO:0051763 name: sesquiterpene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] subset: gosubset_prok is_a: GO:0046247 ! terpene catabolic process is_a: GO:0051761 ! sesquiterpene metabolic process [Term] id: GO:0051764 name: actin crosslink formation namespace: biological_process def: "The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai] comment: See also the molecular function term 'protein binding, bridging ; GO:0030674'. synonym: "actin bundling" RELATED [] synonym: "actin crosslinking" EXACT [] synonym: "bridging actin filaments" NARROW [] synonym: "formation of actin crosslink" EXACT [] is_a: GO:0007015 ! actin filament organization [Term] id: GO:0051765 name: inositol tetrakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai] is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0051766 name: inositol trisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP." [GOC:ai] is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0051767 name: nitric-oxide synthase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, GOC:ai] synonym: "NO synthase biosynthesis" EXACT [] synonym: "NO synthase biosynthetic process" EXACT [] synonym: "NOS biosynthesis" EXACT [] synonym: "NOS biosynthetic process" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0051768 name: nitric-oxide synthase 2 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nitric-oxide synthase 2, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [GOC:ai] synonym: "nitric-oxide synthase (type 2) biosynthesis" EXACT [] synonym: "nitric-oxide synthase (type 2) biosynthetic process" EXACT [] synonym: "nitric-oxide synthase (type II) biosynthesis" EXACT [] synonym: "nitric-oxide synthase (type II) biosynthetic process" EXACT [] synonym: "NOS2 synthase biosynthesis" EXACT [] synonym: "NOS2 synthase biosynthetic process" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0051769 name: regulation of nitric-oxide synthase biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase." [GOC:ai] synonym: "regulation of NO synthase biosynthesis" EXACT [] synonym: "regulation of NO synthase biosynthetic process" EXACT [] synonym: "regulation of NOS biosynthesis" EXACT [] synonym: "regulation of NOS biosynthetic process" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process relationship: regulates GO:0051767 ! nitric-oxide synthase biosynthetic process [Term] id: GO:0051770 name: positive regulation of nitric-oxide synthase biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric oxide synthase." [GOC:ai] synonym: "activation of nitric-oxide synthase biosynthetic process" NARROW [] synonym: "positive regulation of NO synthase biosynthesis" EXACT [] synonym: "positive regulation of NO synthase biosynthetic process" EXACT [] synonym: "positive regulation of NOS biosynthesis" EXACT [] synonym: "positive regulation of NOS biosynthetic process" EXACT [] synonym: "stimulation of nitric-oxide synthase biosynthetic process" NARROW [] synonym: "up regulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "up-regulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "upregulation of nitric-oxide synthase biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process relationship: positively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process [Term] id: GO:0051771 name: negative regulation of nitric-oxide synthase biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase." [GOC:ai] synonym: "down regulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "down-regulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "downregulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "inhibition of nitric-oxide synthase biosynthetic process" NARROW [] synonym: "negative regulation of NO synthase biosynthesis" EXACT [] synonym: "negative regulation of NO synthase biosynthetic process" EXACT [] synonym: "negative regulation of NOS biosynthesis" EXACT [] synonym: "negative regulation of NOS biosynthetic process" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process relationship: negatively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process [Term] id: GO:0051772 name: regulation of nitric-oxide synthase 2 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase 2." [GOC:ai] synonym: "regulation of nitric-oxide synthase (type 2) biosynthesis" EXACT [] synonym: "regulation of nitric-oxide synthase (type 2) biosynthetic process" EXACT [] synonym: "regulation of nitric-oxide synthase (type II) biosynthesis" EXACT [] synonym: "regulation of nitric-oxide synthase (type II) biosynthetic process" EXACT [] synonym: "regulation of NOS2 synthase biosynthesis" EXACT [] synonym: "regulation of NOS2 synthase biosynthetic process" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process relationship: regulates GO:0051768 ! nitric-oxide synthase 2 biosynthetic process [Term] id: GO:0051773 name: positive regulation of nitric-oxide synthase 2 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric oxide synthase 2." [GOC:ai] synonym: "activation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthesis" EXACT [] synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthetic process" EXACT [] synonym: "positive regulation of nitric-oxide synthase (type II) biosynthesis" EXACT [] synonym: "positive regulation of nitric-oxide synthase (type II) biosynthetic process" EXACT [] synonym: "positive regulation of NOS2 synthase biosynthesis" EXACT [] synonym: "positive regulation of NOS2 synthase biosynthetic process" EXACT [] synonym: "stimulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "up regulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] synonym: "up-regulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] synonym: "upregulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0051772 ! regulation of nitric-oxide synthase 2 biosynthetic process relationship: positively_regulates GO:0051768 ! nitric-oxide synthase 2 biosynthetic process [Term] id: GO:0051774 name: negative regulation of nitric-oxide synthase 2 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase 2." [GOC:ai] synonym: "down regulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] synonym: "down-regulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] synonym: "downregulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] synonym: "inhibition of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthesis" EXACT [] synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthetic process" EXACT [] synonym: "negative regulation of nitric-oxide synthase (type II) biosynthesis" EXACT [] synonym: "negative regulation of nitric-oxide synthase (type II) biosynthetic process" EXACT [] synonym: "negative regulation of NOS2 synthase biosynthesis" EXACT [] synonym: "negative regulation of NOS2 synthase biosynthetic process" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0051772 ! regulation of nitric-oxide synthase 2 biosynthetic process relationship: negatively_regulates GO:0051768 ! nitric-oxide synthase 2 biosynthetic process [Term] id: GO:0051775 name: response to redox state namespace: biological_process alt_id: GO:0006980 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039] subset: gosubset_prok synonym: "redox signal response" EXACT [] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0051776 name: detection of redox state namespace: biological_process def: "The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039] synonym: "redox sensing" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051775 ! response to redox state [Term] id: GO:0051777 name: ent-kaurenoate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-159] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. synonym: "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [EC:1.14.13.79] synonym: "ent-kaurenoic acid oxidase activity" EXACT [] xref: MetaCyc:1.14.13.79-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0051778 name: ent-7-alpha-hydroxykaurenoate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. xref: MetaCyc:RXN1F-160 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0051779 name: gibberellin 12-aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-161] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'. synonym: "GA12-aldehyde oxidase activity" EXACT [] xref: MetaCyc:RXN1F-161 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0051780 name: behavioral response to nutrient namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai] synonym: "behavioural response to nutrient" EXACT [] is_a: GO:0007584 ! response to nutrient [Term] id: GO:0051781 name: positive regulation of cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] synonym: "activation of cell division" NARROW [] synonym: "stimulation of cell division" NARROW [] synonym: "up regulation of cell division" EXACT [] synonym: "up-regulation of cell division" EXACT [] synonym: "upregulation of cell division" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051302 ! regulation of cell division relationship: positively_regulates GO:0051301 ! cell division [Term] id: GO:0051782 name: negative regulation of cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai] synonym: "down regulation of cell division" EXACT [] synonym: "down-regulation of cell division" EXACT [] synonym: "downregulation of cell division" EXACT [] synonym: "inhibition of cell division" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051302 ! regulation of cell division relationship: negatively_regulates GO:0051301 ! cell division [Term] id: GO:0051783 name: regulation of nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0000280 ! nuclear division [Term] id: GO:0051784 name: negative regulation of nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "down regulation of nuclear division" EXACT [] synonym: "down-regulation of nuclear division" EXACT [] synonym: "downregulation of nuclear division" EXACT [] synonym: "inhibition of nuclear division" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division relationship: negatively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051785 name: positive regulation of nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "activation of nuclear division" NARROW [] synonym: "stimulation of nuclear division" NARROW [] synonym: "up regulation of nuclear division" EXACT [] synonym: "up-regulation of nuclear division" EXACT [] synonym: "upregulation of nuclear division" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division relationship: positively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051786 name: all-trans-retinol 13,14-reductase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction." [EC:1.3.99.23, RHEA:19196] synonym: "(13,14)-all-trans-retinol saturase activity" EXACT [] synonym: "all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity" EXACT [] synonym: "all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity" EXACT [] synonym: "retinol saturase activity" EXACT [EC:1.3.99.23] synonym: "RetSat activity" EXACT [EC:1.3.99.23] xref: EC:1.3.99.23 xref: KEGG:R07163 xref: MetaCyc:1.3.99.23-RXN xref: RHEA:19196 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0051787 name: misfolded protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a misfolded protein." [GOC:ai] xref: Reactome:262343 "misfolded protein binding" is_a: GO:0005515 ! protein binding [Term] id: GO:0051788 name: response to misfolded protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:go_curators] is_a: GO:0006950 ! response to stress is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051789 ! response to protein stimulus [Term] id: GO:0051789 name: response to protein stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:ai] subset: gosubset_prok is_a: GO:0010033 ! response to organic substance [Term] id: GO:0051790 name: short-chain fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than 8 carbons." [GOC:go_curators] synonym: "short chain fatty acid biosynthesis" EXACT [] synonym: "short chain fatty acid biosynthetic process" EXACT [] synonym: "short-chain fatty acid anabolism" EXACT [] synonym: "short-chain fatty acid biosynthesis" EXACT [] synonym: "short-chain fatty acid formation" EXACT [] synonym: "short-chain fatty acid synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0051791 name: medium-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving medium-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C8-12." [GOC:go_curators] synonym: "medium chain fatty acid metabolic process" EXACT [] synonym: "medium chain fatty acid metabolism" EXACT [] synonym: "medium-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0051792 name: medium-chain fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai] synonym: "medium chain fatty acid biosynthesis" EXACT [] synonym: "medium chain fatty acid biosynthetic process" EXACT [] synonym: "medium-chain fatty acid anabolism" EXACT [] synonym: "medium-chain fatty acid biosynthesis" EXACT [] synonym: "medium-chain fatty acid formation" EXACT [] synonym: "medium-chain fatty acid synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0051791 ! medium-chain fatty acid metabolic process [Term] id: GO:0051793 name: medium-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai] synonym: "medium chain fatty acid catabolic process" EXACT [] synonym: "medium chain fatty acid catabolism" EXACT [] synonym: "medium-chain fatty acid breakdown" EXACT [] synonym: "medium-chain fatty acid catabolism" EXACT [] synonym: "medium-chain fatty acid degradation" EXACT [] is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0051791 ! medium-chain fatty acid metabolic process [Term] id: GO:0051794 name: regulation of catagen namespace: biological_process def: "Any process that modulates the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai] is_a: GO:0048819 ! regulation of hair follicle maturation relationship: regulates GO:0042637 ! catagen [Term] id: GO:0051795 name: positive regulation of catagen namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai] synonym: "activation of catagen" NARROW [] synonym: "stimulation of catagen" NARROW [] synonym: "up regulation of catagen" EXACT [] synonym: "up-regulation of catagen" EXACT [] synonym: "upregulation of catagen" EXACT [] is_a: GO:0048818 ! positive regulation of hair follicle maturation is_a: GO:0051794 ! regulation of catagen relationship: positively_regulates GO:0042637 ! catagen [Term] id: GO:0051796 name: negative regulation of catagen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai] synonym: "down regulation of catagen" EXACT [] synonym: "down-regulation of catagen" EXACT [] synonym: "downregulation of catagen" EXACT [] synonym: "inhibition of catagen" NARROW [] is_a: GO:0048817 ! negative regulation of hair follicle maturation is_a: GO:0051794 ! regulation of catagen relationship: negatively_regulates GO:0042637 ! catagen [Term] id: GO:0051797 name: regulation of hair follicle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hair follicle development." [GOC:ai] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0045682 ! regulation of epidermis development relationship: regulates GO:0001942 ! hair follicle development [Term] id: GO:0051798 name: positive regulation of hair follicle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hair follicle development." [GOC:ai] synonym: "activation of hair follicle development" NARROW [] synonym: "stimulation of hair follicle development" NARROW [] synonym: "up regulation of hair follicle development" EXACT [] synonym: "up-regulation of hair follicle development" EXACT [] synonym: "upregulation of hair follicle development" EXACT [] is_a: GO:0045684 ! positive regulation of epidermis development is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051797 ! regulation of hair follicle development relationship: positively_regulates GO:0001942 ! hair follicle development [Term] id: GO:0051799 name: negative regulation of hair follicle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development." [GOC:ai] synonym: "down regulation of hair follicle development" EXACT [] synonym: "down-regulation of hair follicle development" EXACT [] synonym: "downregulation of hair follicle development" EXACT [] synonym: "inhibition of hair follicle development" NARROW [] is_a: GO:0045683 ! negative regulation of epidermis development is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051797 ! regulation of hair follicle development relationship: negatively_regulates GO:0001942 ! hair follicle development [Term] id: GO:0051800 name: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate." [GOC:bf, PMID:9811831] synonym: "PTEN activity" BROAD [] is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity is_a: GO:0042577 ! lipid phosphatase activity [Term] id: GO:0051801 name: cytolysis in other organism involved in symbiotic interaction namespace: biological_process def: "The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] is_a: GO:0051715 ! cytolysis in other organism is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0051802 name: regulation of cytolysis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0051710 ! regulation of cytolysis in other organism relationship: regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction [Term] id: GO:0051803 name: negative regulation of cytolysis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "down regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [] synonym: "downregulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [] synonym: "inhibition of cytolysis of cells in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "negative regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] is_a: GO:0051713 ! negative regulation of cytolysis in other organism is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction relationship: negatively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction [Term] id: GO:0051804 name: positive regulation of cytolysis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "activation of cytolysis of cells in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "positive regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] synonym: "stimulation of cytolysis of cells in other organism during symbiotic interaction" NARROW [] synonym: "up regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] synonym: "up-regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] synonym: "upregulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] is_a: GO:0051714 ! positive regulation of cytolysis in other organism is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction relationship: positively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction [Term] id: GO:0051805 name: evasion or tolerance of immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism avoids the immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mb] subset: gosubset_prok synonym: "evasion or tolerance of immune response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "immune evasion" EXACT [] is_a: GO:0051807 ! evasion or tolerance of defense response of other organism involved in symbiotic interaction is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction [Term] id: GO:0051806 name: entry into cell of other organism involved in symbiotic interaction namespace: biological_process def: "The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction." [GOC:njm] subset: gosubset_prok synonym: "entry into cell of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "other organism cell invasion" EXACT [] is_a: GO:0051828 ! entry into other organism involved in symbiotic interaction [Term] id: GO:0051807 name: evasion or tolerance of defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense response; the defense response is mounted by the second organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:mah] subset: gosubset_prok synonym: "evasion of other organism defence response" EXACT [] synonym: "evasion or tolerance of defense response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0006952 ! defense response is_a: GO:0051834 ! evasion or tolerance of defenses of other organism involved in symbiotic interaction [Term] id: GO:0051808 name: translocation of peptides or proteins into other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of peptides or proteins produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "translocation of peptides or proteins into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "transport of peptides or proteins into other organism during symbiotic interaction" RELATED [] is_a: GO:0015031 ! protein transport is_a: GO:0051836 ! translocation of molecules into other organism involved in symbiotic interaction [Term] id: GO:0051809 name: passive evasion of immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism avoids the immune response of a second organism without directly interfering with the second organism's immune system, where the two organisms are in a symbiotic interaction." [PMID:12439615] subset: gosubset_prok synonym: "passive evasion of immune response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "passive immune evasion" EXACT [] is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction [Term] id: GO:0051810 name: active evasion of immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism avoids the immune response of a second organism which directly affects the second organism's immune system, where the two organisms are in a symbiotic interaction." [PMID:12439615] subset: gosubset_prok synonym: "active evasion of immune response of other organism during symbiotic interaction" RELATED [GOC:dph, GOC:tb] synonym: "active immune evasion" EXACT [] is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction [Term] id: GO:0051811 name: active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism avoids the immune response of a second organism by regulating the second organism's complement system, where the two organisms are in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] synonym: "active evasion of immune response of other organism via regulation of complement system of other organism during symbiotic interaction" RELATED [GOC:dph, GOC:tb] synonym: "active immune evasion via modulation of complement system of other organism" EXACT [] synonym: "active immune evasion via regulation of complement system of other organism" EXACT [] is_a: GO:0051810 ! active evasion of immune response of other organism involved in symbiotic interaction [Term] id: GO:0051812 name: active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism avoids the immune response of a second organism by regulating the second organism's cytokine networks, where the two organisms are in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] synonym: "active evasion of immune response of other organism via regulation of cytokine network of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "active immune evasion via modulation of cytokine network of other organism" EXACT [] synonym: "active immune evasion via regulation of cytokine network of other organism" EXACT [] is_a: GO:0051810 ! active evasion of immune response of other organism involved in symbiotic interaction [Term] id: GO:0051813 name: active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism avoids the immune response of a second organism by regulating the second organism's antigen processing or presentation pathways, where the two organisms are in a symbiotic interaction." [PMID:12439615] synonym: "active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism during symbiotic interaction" RELATED [GOC:dph, GOC:tb] synonym: "active evasion of immune response of other organism via regulation of antigen processing and presentation pathway in other organism during symbiotic interaction" EXACT [] synonym: "active immune evasion via modulation of antigen processing and presentation in other organism" EXACT [] synonym: "active immune evasion via modulation of antigen processing/presentation in other organism" EXACT [] synonym: "active immune evasion via regulation of antigen processing and presentation in other organism" EXACT [] is_a: GO:0042786 ! active evasion of host immune response via regulation of host antigen processing and presentation [Term] id: GO:0051814 name: movement in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "movement in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "movement within other organism during symbiotic interaction" EXACT [] is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0051815 name: migration in other organism involved in symbiotic interaction namespace: biological_process def: "The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "migration in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "migration within other organism during symbiotic interaction" RELATED [] is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction [Term] id: GO:0051816 name: acquisition of nutrients from other organism during symbiotic interaction namespace: biological_process def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0007631 ! feeding behavior relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0051817 name: modification of morphology or physiology of other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "modification of morphology or physiology of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation of morphology or physiology of other organism during symbiotic interaction" RELATED [] synonym: "regulation of morphology of other organism during symbiotic interaction" NARROW [] synonym: "regulation of morphology or physiology of other organism during symbiotic interaction" RELATED [] synonym: "regulation of physiological process in other organism during symbiotic interaction" NARROW [] synonym: "regulation of physiology of other organism during symbiotic interaction" NARROW [] is_a: GO:0035821 ! modification of morphology or physiology of other organism relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0051818 name: disruption of cells of other organism involved in symbiotic interaction namespace: biological_process def: "A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "disruption of cells of other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0051819 name: induction of tumor, nodule, or growth in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism causes the formation of an abnormal mass of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "induction of tumor, nodule, or growth in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0051820 name: induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism causes the formation in a second organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:cc] synonym: "induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0051819 ! induction of tumor, nodule, or growth in other organism involved in symbiotic interaction [Term] id: GO:0051821 name: dissemination or transmission of organism from other organism involved in symbiotic interaction namespace: biological_process def: "The movement of an organism from a second organism to another place in the environment, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism." [GOC:cc] subset: gosubset_prok synonym: "dissemination or transmission of organism from other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0040011 ! locomotion relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0051822 name: dissemination or transmission of organism from other organism by vector involved in symbiotic interaction namespace: biological_process def: "The movement of an organism from a second organism to another place in the environment by means of a vector, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism, and the vector organism is often an insect or an animal." [GOC:cc] subset: gosubset_prok synonym: "dissemination or transmission of organism from other organism by vector during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0051821 ! dissemination or transmission of organism from other organism involved in symbiotic interaction [Term] id: GO:0051823 name: regulation of synapse structural plasticity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane." [PMID:11063967, PMID:14976517, PMID:9884123] synonym: "regulation of synaptic structural plasticity" EXACT [] is_a: GO:0050807 ! regulation of synapse organization [Term] id: GO:0051824 name: recognition of other organism involved in symbiotic interaction namespace: biological_process def: "The set of specific processes that allow an organism to detect the presence of a second organism via physical or chemical signals, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "recognition of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0009595 ! detection of biotic stimulus relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0051825 name: adhesion to other organism involved in symbiotic interaction namespace: biological_process def: "The attachment of an organism to a second organism, where the two organisms are in a symbiotic interaction. Adhesion may be via adhesion molecules, general stickiness etc., and may be either direct or indirect." [GOC:cc] subset: gosubset_prok synonym: "adhesion to other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0022610 ! biological adhesion relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0051826 name: negative regulation of synapse structural plasticity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse structural plasticity." [GOC:ai] synonym: "down regulation of synapse structural plasticity" EXACT [] synonym: "down-regulation of synapse structural plasticity" EXACT [] synonym: "downregulation of synapse structural plasticity" EXACT [] synonym: "inhibition of synapse structural plasticity" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051823 ! regulation of synapse structural plasticity [Term] id: GO:0051827 name: growth or development on or near surface of other organism during symbiotic interaction namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth on or near surface of other organism during symbiotic interaction ; GO:0044153' and 'development on or near surface of other organism during symbiotic interaction ; GO:0044152'. subset: gosubset_prok is_obsolete: true replaced_by: GO:0044152 replaced_by: GO:0044153 [Term] id: GO:0051828 name: entry into other organism involved in symbiotic interaction namespace: biological_process def: "Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "entry into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "invasion into other organism" EXACT [] synonym: "invasion of other organism" EXACT [] synonym: "invasive growth" RELATED [] synonym: "other organism invasion" EXACT [] is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0051829 name: entry into other organism through natural portals involved in symbiotic interaction namespace: biological_process def: "Penetration by an organism into a second organism via naturally occurring openings in the second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "entry into other organism through natural portals during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0051828 ! entry into other organism involved in symbiotic interaction [Term] id: GO:0051830 name: entry into other organism through barriers of other organism involved in symbiotic interaction namespace: biological_process def: "Penetration by an organism into a second organism via active breaching of physical barriers, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "entry into other organism through barriers of other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0051828 ! entry into other organism involved in symbiotic interaction [Term] id: GO:0051831 name: growth or development in other organism during symbiotic interaction namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth in other organism during symbiotic interaction ; GO:0044112' and 'development in other organism during symbiotic interaction ; GO:0044113'. subset: gosubset_prok synonym: "growth or development within other organism during symbiotic interaction" EXACT [] synonym: "invasive growth" BROAD [] is_obsolete: true replaced_by: GO:0044112 replaced_by: GO:0044113 [Term] id: GO:0051832 name: avoidance of defenses of other organism involved in symbiotic interaction namespace: biological_process def: "Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "avoidance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction [Term] id: GO:0051833 name: suppression of defenses of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense(s) of a second organism, where the two organisms are in a symbiotic interaction. Suppression occurs by active mechanisms that normally result in the shutting down of pathways in the second organism." [GOC:cc] subset: gosubset_prok synonym: "negative regulation of defenses of other organism during symbiotic interaction" RELATED [] synonym: "suppression of defenses of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051832 ! avoidance of defenses of other organism involved in symbiotic interaction [Term] id: GO:0051834 name: evasion or tolerance of defenses of other organism involved in symbiotic interaction namespace: biological_process def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction. Defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers)." [GOC:cc] subset: gosubset_prok synonym: "evasion or tolerance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051832 ! avoidance of defenses of other organism involved in symbiotic interaction [Term] id: GO:0051835 name: positive regulation of synapse structural plasticity namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity." [GOC:ai] synonym: "activation of synapse structural plasticity" NARROW [] synonym: "stimulation of synapse structural plasticity" NARROW [] synonym: "up regulation of synapse structural plasticity" EXACT [] synonym: "up-regulation of synapse structural plasticity" EXACT [] synonym: "upregulation of synapse structural plasticity" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051823 ! regulation of synapse structural plasticity [Term] id: GO:0051836 name: translocation of molecules into other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a molecule(s) produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "translocation of molecules into other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "transport of molecules into other organism during symbiotic interaction" RELATED [] is_a: GO:0006810 ! transport relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0051837 name: translocation of DNA into other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of DNA from an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] synonym: "translocation of DNA into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "transport of DNA into other organism during symbiotic interaction" RELATED [] is_a: GO:0051027 ! DNA transport is_a: GO:0051836 ! translocation of molecules into other organism involved in symbiotic interaction [Term] id: GO:0051838 name: cytolysis by host of symbiont cells namespace: biological_process def: "The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction is_a: GO:0051873 ! killing by host of symbiont cells is_a: GO:0052337 ! modification by host of symbiont cell membrane [Term] id: GO:0051839 name: regulation by host of cytolysis of symbiont cells namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction relationship: regulates GO:0051838 ! cytolysis by host of symbiont cells [Term] id: GO:0051840 name: negative regulation by host of cytolysis of symbiont cells namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "down regulation by host of cytolysis of symbiont cells" EXACT [] synonym: "down-regulation by host of cytolysis of symbiont cells" EXACT [] synonym: "downregulation by host of cytolysis of symbiont cells" EXACT [] synonym: "inhibition by host of cytolysis of symbiont cells" NARROW [] is_a: GO:0051803 ! negative regulation of cytolysis in other organism involved in symbiotic interaction is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells [Term] id: GO:0051841 name: positive regulation by host of cytolysis of symbiont cells namespace: biological_process def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "activation by host of cytolysis of symbiont cells" NARROW [] synonym: "stimulation by host of cytolysis of symbiont cells" NARROW [] synonym: "up regulation by host of cytolysis of symbiont cells" EXACT [] synonym: "up-regulation by host of cytolysis of symbiont cells" EXACT [] synonym: "upregulation by host of cytolysis of symbiont cells" EXACT [] is_a: GO:0051804 ! positive regulation of cytolysis in other organism involved in symbiotic interaction is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells [Term] id: GO:0051842 name: evasion or tolerance of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process, either active or passive, by which an organism avoids the effects of the symbiont organism's immune response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mb] comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. synonym: "immune evasion" BROAD [] is_obsolete: true [Term] id: GO:0051843 name: evasion or tolerance of symbiont defense response namespace: biological_process def: "OBSOLETE. Any process, either active or passive, by which an organism avoids or tolerates the effects of a symbiont organism's defense response. The symbiont defense response is mounted by the symbiont in response to the presence of the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mah] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "evasion of symbiont defence response" EXACT [] is_obsolete: true [Term] id: GO:0051844 name: translocation of peptides or proteins into symbiont namespace: biological_process def: "The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "transport of peptides or proteins into symbiont" EXACT [] is_a: GO:0051808 ! translocation of peptides or proteins into other organism involved in symbiotic interaction is_a: GO:0051862 ! translocation of molecules into symbiont [Term] id: GO:0051845 name: passive evasion of symbiont immune response namespace: biological_process def: "OBSOLETE. Any mechanism of immune avoidance that does not directly interfere with the symbiont immune system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "passive immune evasion" BROAD [] is_obsolete: true [Term] id: GO:0051846 name: active evasion of symbiont immune response namespace: biological_process def: "OBSOLETE. Any mechanism of immune avoidance that directly affects the symbiont immune system, e.g. blocking any stage in symbiont MHC class I and II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "active immune evasion" BROAD [] is_obsolete: true [Term] id: GO:0051847 name: active evasion of symbiont immune response via regulation of symbiont complement system namespace: biological_process def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, symbiont macrophages, which are eventually destroyed. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "active immune evasion via modulation of symbiont complement system" EXACT [] synonym: "active immune evasion via regulation of symbiont complement system" EXACT [] is_obsolete: true [Term] id: GO:0051848 name: active evasion of symbiont immune response via regulation of symbiont cytokine network namespace: biological_process def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "active immune evasion via modulation of symbiont cytokine network" EXACT [] synonym: "active immune evasion via regulation of symbiont cytokine network" EXACT [] is_obsolete: true [Term] id: GO:0051849 name: active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation namespace: biological_process def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation pathway" EXACT [] synonym: "active immune evasion via modulation of symbiont antigen processing and presentation" EXACT [] synonym: "active immune evasion via modulation of symbiont antigen processing/presentation" EXACT [] synonym: "active immune evasion via regulation of symbiont antigen processing or presentation" EXACT [] is_obsolete: true [Term] id: GO:0051850 name: acquisition of nutrients from symbiont namespace: biological_process def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0051702 ! interaction with symbiont is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction [Term] id: GO:0051851 name: modification by host of symbiont morphology or physiology namespace: biological_process def: "The process in which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0051702 ! interaction with symbiont is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0051852 name: disruption by host of symbiont cells namespace: biological_process def: "Any process in which an organism has a negative effect on the functioning of the symbiont's cells. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0051818 ! disruption of cells of other organism involved in symbiotic interaction is_a: GO:0051851 ! modification by host of symbiont morphology or physiology [Term] id: GO:0051853 name: induction in symbiont of tumor, nodule, or growth namespace: biological_process def: "OBSOLETE. The process by which an associated organism causes the formation of an abnormal mass of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it does not represent a real process that exists in nature. is_obsolete: true [Term] id: GO:0051854 name: induction in symbiont of tumor, nodule, or growth containing transformed cells namespace: biological_process def: "OBSOLETE. The process by which an organism causes the formation in its symbiont organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it does not represent a real process that exists in nature. is_obsolete: true [Term] id: GO:0051855 name: recognition of symbiont namespace: biological_process def: "The set of specific processes that allow an organism to detect the presence of its symbiont via physical or chemical signals. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0009602 ! detection of symbiont is_a: GO:0051702 ! interaction with symbiont is_a: GO:0051824 ! recognition of other organism involved in symbiotic interaction [Term] id: GO:0051856 name: adhesion to symbiont namespace: biological_process def: "The attachment of an organism to its symbiont via adhesion molecules, general stickiness etc., either directly or indirectly. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0051702 ! interaction with symbiont is_a: GO:0051825 ! adhesion to other organism involved in symbiotic interaction [Term] id: GO:0051857 name: growth or development of organism on or near symbiont surface namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of organism on or near symbiont surface ; GO:0044151' and 'development of organism on or near symbiont surface ; GO:0044150'. subset: gosubset_prok synonym: "growth or development of organism during interaction with symbiont" EXACT [] is_obsolete: true replaced_by: GO:0044150 replaced_by: GO:0044151 [Term] id: GO:0051858 name: avoidance of symbiont defenses namespace: biological_process def: "Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of its symbiont organism's defense(s). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0051702 ! interaction with symbiont is_a: GO:0051832 ! avoidance of defenses of other organism involved in symbiotic interaction is_a: GO:0052201 ! response to symbiont defenses [Term] id: GO:0051859 name: suppression of symbiont defenses namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont defense(s) by active mechanisms that normally result in the shutting down of a symbiont pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0051833 ! suppression of defenses of other organism involved in symbiotic interaction is_a: GO:0051858 ! avoidance of symbiont defenses [Term] id: GO:0051860 name: evasion or tolerance of symbiont defenses namespace: biological_process def: "The process, either active or passive, by which an organism evades or tolerates the effects of the defense(s) or defense molecules of a symbiont organism. Symbiont defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok is_a: GO:0051834 ! evasion or tolerance of defenses of other organism involved in symbiotic interaction is_a: GO:0051858 ! avoidance of symbiont defenses [Term] id: GO:0051861 name: glycolipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html#2.1] is_a: GO:0008289 ! lipid binding [Term] id: GO:0051862 name: translocation of molecules into symbiont namespace: biological_process def: "The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "transport of molecules into symbiont" EXACT [] is_a: GO:0051702 ! interaction with symbiont is_a: GO:0051836 ! translocation of molecules into other organism involved in symbiotic interaction [Term] id: GO:0051863 name: translocation of DNA into symbiont namespace: biological_process def: "OBSOLETE. The directed movement of DNA from an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it does not represent a real process that exists in nature. is_obsolete: true [Term] id: GO:0051864 name: histone demethylase activity (H3-K36 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein." [PMID:16362057] synonym: "[histone-H3]-lysine-36 demethylase activity" EXACT [] synonym: "H3-K36-specific demethylase activity" EXACT [EC:1.14.11.27] synonym: "histone H3-lysine-36 demethylase activity" EXACT [EC:1.14.11.27] synonym: "histone-lysine (H3-K36) demethylase activity" EXACT [EC:1.14.11.27] synonym: "histone-lysine demethylase activity (H3-K36 specific)" EXACT [] synonym: "histone-lysine(H3-K36) demethylase activity" EXACT [] synonym: "JHDM1A activity" NARROW [EC:1.14.11.27] synonym: "JmjC domain-containing histone demethylase 1A activity" NARROW [EC:1.14.11.27] synonym: "protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27] synonym: "protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27] xref: EC:1.14.11.27 xref: MetaCyc:RXN-8660 xref: MetaCyc:RXN-8661 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors is_a: GO:0032452 ! histone demethylase activity [Term] id: GO:0051865 name: protein autoubiquitination namespace: biological_process def: "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai] synonym: "protein auto-ubiquitination" EXACT [] synonym: "protein auto-ubiquitinylation" EXACT [] synonym: "protein autoubiquitinylation" EXACT [] synonym: "protein self-ubiquitination" EXACT [] synonym: "protein self-ubiquitinylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0051866 name: general adaptation syndrome namespace: biological_process alt_id: GO:0051868 def: "General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses." [http://www.onelook.com, PMID:14847556, Wikipedia:General_adaptation_syndrome] synonym: "general adaptation syndrome, physiological process" EXACT [] synonym: "general adaptation syndrome, physiological response" EXACT [] synonym: "physiological process during general adaptation syndrome" EXACT [] synonym: "physiological response during general adaptation syndrome" EXACT [] is_a: GO:0033555 ! multicellular organismal response to stress [Term] id: GO:0051867 name: general adaptation syndrome, behavioral process namespace: biological_process def: "The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus." [GOC:ai] synonym: "behavioral process during general adaptation syndrome" EXACT [] synonym: "behavioral response during general adaptation syndrome" EXACT [] synonym: "behavioural process during general adaptation syndrome" EXACT [] synonym: "behavioural response during general adaptation syndrome" EXACT [] synonym: "general adaptation syndrome, behavioral response" EXACT [] synonym: "general adaptation syndrome, behavioural process" EXACT [] synonym: "general adaptation syndrome, behavioural response" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0051866 ! general adaptation syndrome [Term] id: GO:0051870 name: methotrexate binding namespace: molecular_function def: "Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln] subset: gosubset_prok is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0051871 name: dihydrofolic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "DHF binding" RELATED [] synonym: "dihydrofolate binding" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0051872 name: sphingosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ai] synonym: "(4E)-sphing-4-enine catabolic process" EXACT [] synonym: "(4E)-sphing-4-enine catabolism" EXACT [] synonym: "sphing-4-enine catabolic process" EXACT [] synonym: "sphing-4-enine catabolism" EXACT [] is_a: GO:0006670 ! sphingosine metabolic process is_a: GO:0009310 ! amine catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0046521 ! sphingoid catabolic process [Term] id: GO:0051873 name: killing by host of symbiont cells namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok is_a: GO:0051852 ! disruption by host of symbiont cells is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0051874 name: sphinganine-1-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] synonym: "dihydrosphingosine-1-phosphate catabolic process" EXACT [] synonym: "dihydrosphingosine-1-phosphate catabolism" EXACT [] is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process [Term] id: GO:0051875 name: pigment granule localization namespace: biological_process def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization relationship: part_of GO:0033059 ! cellular pigmentation [Term] id: GO:0051876 name: pigment granule dispersal namespace: biological_process def: "The directed movement of pigment granules within a cell towards the cell periphery." [GOC:mh] is_a: GO:0051905 ! establishment of pigment granule localization [Term] id: GO:0051877 name: pigment granule aggregation in cell center namespace: biological_process def: "The directed movement of dispersed pigment granules towards the center of the cell." [GOC:mh] is_a: GO:0051905 ! establishment of pigment granule localization [Term] id: GO:0051878 name: lateral element assembly namespace: biological_process def: "The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847] is_a: GO:0022402 ! cell cycle process is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0007130 ! synaptonemal complex assembly [Term] id: GO:0051879 name: Hsp90 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai] synonym: "Hsp90 binding" EXACT [] synonym: "Hsp90 class protein binding" EXACT [] is_a: GO:0031072 ! heat shock protein binding [Term] id: GO:0051880 name: G-quadruplex DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome." [PMID:16142245, PMID:9512530] synonym: "G quadruplex DNA binding" EXACT [GOC:mah] synonym: "G quartet binding" BROAD [GOC:mah] synonym: "G quartet DNA binding" EXACT [GOC:mah] synonym: "G-DNA binding" EXACT [] synonym: "G-quartet binding" BROAD [GOC:mah] synonym: "G-quartet DNA binding" EXACT [GOC:mah] synonym: "quadruplex DNA binding" EXACT [] synonym: "tetraplex DNA binding" EXACT [] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0051881 name: regulation of mitochondrial membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0051882 name: mitochondrial depolarization namespace: biological_process def: "The process in which the membrane potential of the mitochondria changes in the depolarizing direction from the resting potential, from negative to positive." [Wikipedia:Depolarization, Wikipedia:Mitochondrion] synonym: "mitochondria depolarization" EXACT [] synonym: "mitochondrial depolarisation" EXACT [] synonym: "mitochondrial membrane depolarization" EXACT [] synonym: "mitochondrion depolarization" EXACT [] is_a: GO:0051881 ! regulation of mitochondrial membrane potential is_a: GO:0051899 ! membrane depolarization [Term] id: GO:0051883 name: killing of cells in other organism involved in symbiotic interaction namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "killing of cells in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0031640 ! killing of cells of other organism is_a: GO:0051818 ! disruption of cells of other organism involved in symbiotic interaction [Term] id: GO:0051884 name: regulation of anagen namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0048819 ! regulation of hair follicle maturation relationship: regulates GO:0042640 ! anagen [Term] id: GO:0051885 name: positive regulation of anagen namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai] synonym: "activation of anagen" NARROW [] synonym: "stimulation of anagen" NARROW [] synonym: "up regulation of anagen" EXACT [] synonym: "up-regulation of anagen" EXACT [] synonym: "upregulation of anagen" EXACT [] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048818 ! positive regulation of hair follicle maturation is_a: GO:0051884 ! regulation of anagen relationship: positively_regulates GO:0042640 ! anagen [Term] id: GO:0051886 name: negative regulation of anagen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai] synonym: "down regulation of anagen" EXACT [] synonym: "down-regulation of anagen" EXACT [] synonym: "downregulation of anagen" EXACT [] synonym: "inhibition of anagen" NARROW [] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0048817 ! negative regulation of hair follicle maturation is_a: GO:0051884 ! regulation of anagen relationship: negatively_regulates GO:0042640 ! anagen [Term] id: GO:0051887 name: regulation of exogen namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai] is_a: GO:0048819 ! regulation of hair follicle maturation relationship: regulates GO:0042638 ! exogen [Term] id: GO:0051888 name: positive regulation of exogen namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai] synonym: "activation of exogen" NARROW [] synonym: "stimulation of exogen" NARROW [] synonym: "up regulation of exogen" EXACT [] synonym: "up-regulation of exogen" EXACT [] synonym: "upregulation of exogen" EXACT [] is_a: GO:0048818 ! positive regulation of hair follicle maturation is_a: GO:0051887 ! regulation of exogen relationship: positively_regulates GO:0042638 ! exogen [Term] id: GO:0051889 name: negative regulation of exogen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai] synonym: "down regulation of exogen" EXACT [] synonym: "down-regulation of exogen" EXACT [] synonym: "downregulation of exogen" EXACT [] synonym: "inhibition of exogen" NARROW [] is_a: GO:0048817 ! negative regulation of hair follicle maturation is_a: GO:0051887 ! regulation of exogen relationship: negatively_regulates GO:0042638 ! exogen [Term] id: GO:0051890 name: regulation of cardioblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0010002 ! cardioblast differentiation [Term] id: GO:0051891 name: positive regulation of cardioblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "activation of cardioblast differentiation" NARROW [] synonym: "stimulation of cardioblast differentiation" NARROW [] synonym: "up regulation of cardioblast differentiation" EXACT [] synonym: "up-regulation of cardioblast differentiation" EXACT [] synonym: "upregulation of cardioblast differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051890 ! regulation of cardioblast differentiation relationship: positively_regulates GO:0010002 ! cardioblast differentiation [Term] id: GO:0051892 name: negative regulation of cardioblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "down regulation of cardioblast differentiation" EXACT [] synonym: "down-regulation of cardioblast differentiation" EXACT [] synonym: "downregulation of cardioblast differentiation" EXACT [] synonym: "inhibition of cardioblast differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051890 ! regulation of cardioblast differentiation relationship: negatively_regulates GO:0010002 ! cardioblast differentiation [Term] id: GO:0051893 name: regulation of focal adhesion assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0090109 ! regulation of cell-substrate junction assembly relationship: regulates GO:0048041 ! focal adhesion assembly [Term] id: GO:0051894 name: positive regulation of focal adhesion assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai] synonym: "activation of focal adhesion formation" NARROW [] synonym: "stimulation of focal adhesion formation" NARROW [] synonym: "up regulation of focal adhesion formation" EXACT [] synonym: "up-regulation of focal adhesion formation" EXACT [] synonym: "upregulation of focal adhesion formation" EXACT [] is_a: GO:0001954 ! positive regulation of cell-matrix adhesion is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051893 ! regulation of focal adhesion assembly relationship: positively_regulates GO:0048041 ! focal adhesion assembly [Term] id: GO:0051895 name: negative regulation of focal adhesion assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai] synonym: "down regulation of focal adhesion formation" EXACT [] synonym: "down-regulation of focal adhesion formation" EXACT [] synonym: "downregulation of focal adhesion formation" EXACT [] synonym: "inhibition of focal adhesion formation" NARROW [] is_a: GO:0001953 ! negative regulation of cell-matrix adhesion is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051893 ! regulation of focal adhesion assembly relationship: negatively_regulates GO:0048041 ! focal adhesion assembly [Term] id: GO:0051896 name: regulation of protein kinase B signaling cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] synonym: "regulation of AKT signaling cascade" EXACT [] synonym: "regulation of AKT signalling cascade" EXACT [] synonym: "regulation of PKB signaling cascade" EXACT [] synonym: "regulation of PKB signalling cascade" EXACT [] synonym: "regulation of protein kinase B signalling cascade" EXACT [] is_a: GO:0010627 ! regulation of intracellular protein kinase cascade relationship: regulates GO:0043491 ! protein kinase B signaling cascade [Term] id: GO:0051897 name: positive regulation of protein kinase B signaling cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] synonym: "activation of protein kinase B signaling cascade" NARROW [] synonym: "positive regulation of AKT signaling cascade" EXACT [] synonym: "positive regulation of AKT signalling cascade" EXACT [] synonym: "positive regulation of PKB signaling cascade" EXACT [] synonym: "positive regulation of PKB signalling cascade" EXACT [] synonym: "positive regulation of protein kinase B signalling cascade" EXACT [] synonym: "stimulation of protein kinase B signaling cascade" NARROW [] synonym: "up regulation of protein kinase B signaling cascade" EXACT [] synonym: "up-regulation of protein kinase B signaling cascade" EXACT [] synonym: "upregulation of protein kinase B signaling cascade" EXACT [] is_a: GO:0010740 ! positive regulation of intracellular protein kinase cascade is_a: GO:0051896 ! regulation of protein kinase B signaling cascade relationship: positively_regulates GO:0043491 ! protein kinase B signaling cascade [Term] id: GO:0051898 name: negative regulation of protein kinase B signaling cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] synonym: "down regulation of protein kinase B signaling cascade" EXACT [] synonym: "down-regulation of protein kinase B signaling cascade" EXACT [] synonym: "downregulation of protein kinase B signaling cascade" EXACT [] synonym: "inhibition of protein kinase B signaling cascade" NARROW [] synonym: "negative regulation of AKT signaling cascade" EXACT [] synonym: "negative regulation of AKT signalling cascade" EXACT [] synonym: "negative regulation of PKB signaling cascade" EXACT [] synonym: "negative regulation of PKB signalling cascade" EXACT [] synonym: "negative regulation of protein kinase B signalling cascade" EXACT [] is_a: GO:0010741 ! negative regulation of intracellular protein kinase cascade is_a: GO:0051896 ! regulation of protein kinase B signaling cascade relationship: negatively_regulates GO:0043491 ! protein kinase B signaling cascade [Term] id: GO:0051899 name: membrane depolarization namespace: biological_process def: "The process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [Wikipedia:Depolarization] xref: Reactome:112308 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" xref: Reactome:1253573 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" xref: Reactome:1280508 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" xref: Reactome:1299338 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" xref: Reactome:1327090 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" xref: Reactome:1353184 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" xref: Reactome:1373362 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" xref: Reactome:1393385 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" xref: Reactome:1417881 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" xref: Reactome:1450971 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels" is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0051900 name: regulation of mitochondrial depolarization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] is_a: GO:0003254 ! regulation of membrane depolarization relationship: regulates GO:0051882 ! mitochondrial depolarization [Term] id: GO:0051901 name: positive regulation of mitochondrial depolarization namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] synonym: "activation of mitochondrial depolarization" NARROW [] synonym: "stimulation of mitochondrial depolarization" NARROW [] synonym: "up regulation of mitochondrial depolarization" EXACT [] synonym: "up-regulation of mitochondrial depolarization" EXACT [] synonym: "upregulation of mitochondrial depolarization" EXACT [] is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051900 ! regulation of mitochondrial depolarization relationship: positively_regulates GO:0051882 ! mitochondrial depolarization [Term] id: GO:0051902 name: negative regulation of mitochondrial depolarization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] synonym: "down regulation of mitochondrial depolarization" EXACT [] synonym: "down-regulation of mitochondrial depolarization" EXACT [] synonym: "downregulation of mitochondrial depolarization" EXACT [] synonym: "inhibition of mitochondrial depolarization" NARROW [] is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051900 ! regulation of mitochondrial depolarization relationship: negatively_regulates GO:0051882 ! mitochondrial depolarization [Term] id: GO:0051903 name: S-(hydroxymethyl)glutathione dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284] synonym: "ADH3 activity" NARROW [EC:1.1.1.284] synonym: "chi-ADH activity" NARROW [EC:1.1.1.284] synonym: "class III alcohol dehydrogenase activity" RELATED [EC:1.1.1.284] synonym: "FDH activity" RELATED [EC:1.1.1.284] synonym: "formic dehydrogenase activity" RELATED [EC:1.1.1.284] synonym: "GD-FALDH activity" EXACT [EC:1.1.1.284] synonym: "glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "GS-FDH activity" EXACT [EC:1.1.1.284] synonym: "NAD- and glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "NAD-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "NAD-linked formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.284] xref: EC:1.1.1.284 xref: MetaCyc:RXN-2962 xref: UM-BBD_reactionID:r1146 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0051904 name: pigment granule transport namespace: biological_process def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "pigment granule translocation" EXACT [] is_a: GO:0006810 ! transport is_a: GO:0051905 ! establishment of pigment granule localization [Term] id: GO:0051905 name: establishment of pigment granule localization namespace: biological_process def: "The directed movement of a pigment granule to a specific location." [GOC:ai] synonym: "establishment of pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051650 ! establishment of vesicle localization relationship: part_of GO:0051875 ! pigment granule localization [Term] id: GO:0051906 name: maintenance of pigment granule location namespace: biological_process def: "Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of pigment granule localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051655 ! maintenance of vesicle location relationship: part_of GO:0051875 ! pigment granule localization [Term] id: GO:0051907 name: S-(hydroxymethyl)glutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione." [EC:4.4.1.22, RHEA:22491] synonym: "Gfa" RELATED [EC:4.4.1.22] synonym: "glutathione-dependent formaldehyde-activating enzyme activity" EXACT [] synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)" EXACT [EC:4.4.1.22] synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase activity" EXACT [EC:4.4.1.22] xref: EC:4.4.1.22 xref: KEGG:R06982 xref: MetaCyc:RXN-2961 xref: RHEA:22491 xref: UM-BBD_reactionID:r1145 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0051908 name: double-stranded DNA specific 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai] is_a: GO:0008309 ! double-stranded DNA specific exodeoxyribonuclease activity is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity [Term] id: GO:0051909 name: acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O." [MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN] synonym: "3-hydroxypropenoate dehydratase activity" EXACT [] synonym: "acetylenecarboxylate hydratase activity" BROAD [] synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] synonym: "alkynoate hydratase activity" BROAD [] xref: EC:4.2.1.- is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0051911 name: Methanosarcina-phenazine hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine." [EC:1.12.98.3] synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] synonym: "hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity" EXACT [EC:1.12.98.3] synonym: "methanophenazine hydrogenase activity" EXACT [] synonym: "methylviologen-reducing hydrogenase activity" EXACT [] xref: EC:1.12.98.3 xref: MetaCyc:RXN-7733 is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors [Term] id: GO:0051912 name: CoB--CoM heterodisulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine." [EC:1.8.98.1] synonym: "CoB-CoM heterodisulfide reductase activity" EXACT [] synonym: "coenzyme B--coenzyme M heterodisulfide reductase activity" EXACT [] synonym: "coenzyme B:coenzyme M:methanophenazine oxidoreductase activity" EXACT [EC:1.8.98.1] synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] synonym: "heterodisulfide reductase activity" BROAD [] synonym: "soluble heterodisulfide reductase activity" RELATED [EC:1.8.98.1] xref: EC:1.8.98.1 xref: MetaCyc:1.8.98.1-RXN is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0051913 name: regulation of synaptic plasticity by chemical substance namespace: biological_process def: "The process in which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] synonym: "regulation of synaptic plasticity by drug" NARROW [] is_a: GO:0042221 ! response to chemical stimulus is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0051914 name: positive regulation of synaptic plasticity by chemical substance namespace: biological_process def: "The process in which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] synonym: "activation of synaptic plasticity by chemical substance" NARROW [] synonym: "positive regulation of synaptic plasticity by drug" NARROW [] synonym: "stimulation of synaptic plasticity by chemical substance" NARROW [] synonym: "up regulation of synaptic plasticity by chemical substance" EXACT [] synonym: "up-regulation of synaptic plasticity by chemical substance" EXACT [] synonym: "upregulation of synaptic plasticity by chemical substance" EXACT [] is_a: GO:0031915 ! positive regulation of synaptic plasticity is_a: GO:0051913 ! regulation of synaptic plasticity by chemical substance [Term] id: GO:0051915 name: induction of synaptic plasticity by chemical substance namespace: biological_process def: "The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] synonym: "activation of synaptic plasticity by chemical substance" EXACT [] synonym: "activation of synaptic plasticity by drug" NARROW [] synonym: "induction of synaptic plasticity by drug" NARROW [] is_a: GO:0051914 ! positive regulation of synaptic plasticity by chemical substance [Term] id: GO:0051916 name: granulocyte colony-stimulating factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with granulocyte colony-stimulating factor, G-CSF." [GOC:ai] synonym: "G-CSF binding" EXACT [] synonym: "granulocyte colony stimulating factor binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0051917 name: regulation of fibrinolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0042730 ! fibrinolysis [Term] id: GO:0051918 name: negative regulation of fibrinolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] synonym: "down regulation of fibrinolysis" EXACT [] synonym: "down-regulation of fibrinolysis" EXACT [] synonym: "downregulation of fibrinolysis" EXACT [] synonym: "inhibition of fibrinolysis" NARROW [] is_a: GO:0030194 ! positive regulation of blood coagulation is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051917 ! regulation of fibrinolysis relationship: negatively_regulates GO:0042730 ! fibrinolysis [Term] id: GO:0051919 name: positive regulation of fibrinolysis namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] synonym: "activation of fibrinolysis" NARROW [] synonym: "stimulation of fibrinolysis" NARROW [] synonym: "up regulation of fibrinolysis" EXACT [] synonym: "up-regulation of fibrinolysis" EXACT [] synonym: "upregulation of fibrinolysis" EXACT [] is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051917 ! regulation of fibrinolysis relationship: positively_regulates GO:0042730 ! fibrinolysis [Term] id: GO:0051920 name: peroxiredoxin activity namespace: molecular_function def: "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15] subset: gosubset_prok synonym: "AhpC activity" NARROW [] synonym: "alkyl hydroperoxide reductase C22 activity" NARROW [] synonym: "PRDX activity" EXACT [] synonym: "Prx activity" EXACT [] synonym: "thiol-containing-reductant:hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.15] xref: EC:1.11.1.15 xref: MetaCyc:1.11.1.15-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0051921 name: adenosylcobyric acid synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H(2)O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H(+) + 4 phosphate." [EC:6.3.5.10, RHEA:23259] synonym: "5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity" EXACT [] synonym: "adenosylcobyric acid synthase (glutamine-hydrolysing) activity" EXACT [] synonym: "adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.10] synonym: "Ado-cobyric acid synthase [glutamine hydrolyzing] activity" EXACT [] synonym: "CobQ activity" BROAD [] synonym: "cobyric acid synthase activity" RELATED [] xref: EC:6.3.5.10 xref: KEGG:R05225 xref: MetaCyc:R345-RXN xref: RHEA:23259 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0051922 name: cholesterol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate." [PMID:12730293] xref: EC:2.8.2.- is_a: GO:0004027 ! alcohol sulfotransferase activity [Term] id: GO:0051923 name: sulfation namespace: biological_process def: "The addition of a sulfate group to a molecule." [http://www.onelook.com] subset: gosubset_prok synonym: "phase II metabolism" BROAD [PMID:20056724] synonym: "sulfonation" EXACT [] synonym: "sulfur addition" EXACT [] synonym: "sulphation" EXACT [] synonym: "sulphur addition" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0051924 name: regulation of calcium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "regulation of calcium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport relationship: regulates GO:0006816 ! calcium ion transport [Term] id: GO:0051925 name: regulation of calcium ion transport via voltage-gated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai] synonym: "regulation of calcium transport via voltage-gated calcium channel" EXACT [] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0051924 ! regulation of calcium ion transport [Term] id: GO:0051926 name: negative regulation of calcium ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of calcium ion transport" EXACT [] synonym: "down-regulation of calcium ion transport" EXACT [] synonym: "downregulation of calcium ion transport" EXACT [] synonym: "inhibition of calcium ion transport" NARROW [] synonym: "negative regulation of calcium transport" EXACT [] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051924 ! regulation of calcium ion transport relationship: negatively_regulates GO:0006816 ! calcium ion transport [Term] id: GO:0051927 name: negative regulation of calcium ion transport via voltage-gated calcium channel activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai] synonym: "down regulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "down-regulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "downregulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "inhibition of calcium ion transport via voltage gated calcium channel" NARROW [] synonym: "negative regulation of calcium transport via voltage gated calcium channel" RELATED [] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel activity is_a: GO:0051926 ! negative regulation of calcium ion transport [Term] id: GO:0051928 name: positive regulation of calcium ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of calcium ion transport" NARROW [] synonym: "positive regulation of calcium transport" EXACT [] synonym: "stimulation of calcium ion transport" NARROW [] synonym: "up regulation of calcium ion transport" EXACT [] synonym: "up-regulation of calcium ion transport" EXACT [] synonym: "upregulation of calcium ion transport" EXACT [] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051924 ! regulation of calcium ion transport relationship: positively_regulates GO:0006816 ! calcium ion transport [Term] id: GO:0051929 name: positive regulation of calcium ion transport via voltage-gated calcium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via the activity of voltage-gated calcium channels." [GOC:ai] synonym: "activation of calcium ion transport via voltage gated calcium channel" NARROW [] synonym: "positive regulation of calcium transport via voltage gated calcium channel" EXACT [] synonym: "stimulation of calcium ion transport via voltage gated calcium channel" NARROW [] synonym: "up regulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "up-regulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "upregulation of calcium ion transport via voltage gated calcium channel" EXACT [] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel activity is_a: GO:0051928 ! positive regulation of calcium ion transport [Term] id: GO:0051930 name: regulation of sensory perception of pain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0051931 ! regulation of sensory perception relationship: regulates GO:0019233 ! sensory perception of pain [Term] id: GO:0051931 name: regulation of sensory perception namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0031644 ! regulation of neurological system process relationship: regulates GO:0007600 ! sensory perception [Term] id: GO:0051932 name: synaptic transmission, GABAergic namespace: biological_process def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [ISBN:0126603030] synonym: "synaptic transmission, GABA mediated" EXACT [] synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT [] synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT [] is_a: GO:0007270 ! neuron-neuron synaptic transmission [Term] id: GO:0051933 name: amino acid uptake involved in synaptic transmission namespace: biological_process def: "The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] synonym: "amino acid neurotransmitter import into glial cell" NARROW [] synonym: "amino acid neurotransmitter import into neuron" NARROW [] synonym: "amino acid neurotransmitter recycling" BROAD [] synonym: "amino acid neurotransmitter reuptake" EXACT [] synonym: "amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0043090 ! amino acid import [Term] id: GO:0051934 name: catecholamine uptake involved in synaptic transmission namespace: biological_process def: "The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] synonym: "catecholamine neurotransmitter import into glial cell" NARROW [] synonym: "catecholamine neurotransmitter import into neuron" NARROW [] synonym: "catecholamine neurotransmitter recycling" BROAD [] synonym: "catecholamine neurotransmitter reuptake" EXACT [] synonym: "catecholamine reuptake during transmission of nerve impulse" RELATED [] synonym: "catecholamine uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0051935 name: glutamate uptake involved in synaptic transmission namespace: biological_process def: "The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] synonym: "glutamate import into glial cell" NARROW [] synonym: "glutamate import into neuron" NARROW [] synonym: "glutamate recycling" BROAD [] synonym: "glutamate reuptake" EXACT [] synonym: "glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "L-glutamate reuptake" EXACT [] synonym: "L-glutamate uptake during transmission of nerve impulse" RELATED [] is_a: GO:0051933 ! amino acid uptake involved in synaptic transmission is_a: GO:0051938 ! L-glutamate import [Term] id: GO:0051936 name: gamma-aminobutyric acid uptake involved in synaptic transmission namespace: biological_process def: "The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] synonym: "GABA import into glial cell" NARROW [] synonym: "GABA import into neuron" NARROW [] synonym: "GABA recycling" BROAD [] synonym: "GABA reuptake" EXACT [] synonym: "gamma-aminobutyric acid import into glial cell" NARROW [] synonym: "gamma-aminobutyric acid import into neuron" NARROW [] synonym: "gamma-aminobutyric acid recycling" BROAD [] synonym: "gamma-aminobutyric acid reuptake" EXACT [] synonym: "gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0051933 ! amino acid uptake involved in synaptic transmission is_a: GO:0051939 ! gamma-aminobutyric acid import [Term] id: GO:0051937 name: catecholamine transport namespace: biological_process def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic alcohol transport [Term] id: GO:0051938 name: L-glutamate import namespace: biological_process def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015813 ! L-glutamate transport is_a: GO:0043092 ! L-amino acid import [Term] id: GO:0051939 name: gamma-aminobutyric acid import namespace: biological_process def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai] subset: gosubset_prok synonym: "4-aminobutyrate import" EXACT [] synonym: "GABA import" EXACT [] synonym: "gamma-aminobutyrate import" EXACT [] synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0043092 ! L-amino acid import [Term] id: GO:0051940 name: regulation of catecholamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai] synonym: "regulation of catecholamine neurotransmitter reuptake" EXACT [] synonym: "regulation of catecholamine neurotransmitter uptake" EXACT [] synonym: "regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051952 ! regulation of amine transport relationship: regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission [Term] id: GO:0051941 name: regulation of amino acid uptake involved in synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] synonym: "regulation of amino acid neurotransmitter reuptake" EXACT [] synonym: "regulation of amino acid neurotransmitter uptake" EXACT [] synonym: "regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0010958 ! regulation of amino acid import is_a: GO:0051580 ! regulation of neurotransmitter uptake relationship: regulates GO:0051933 ! amino acid uptake involved in synaptic transmission [Term] id: GO:0051942 name: negative regulation of amino acid uptake involved in synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] synonym: "down regulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "down-regulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "downregulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "inhibition of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "negative regulation of amino acid neurotransmitter reuptake" EXACT [] synonym: "negative regulation of amino acid neurotransmitter uptake" EXACT [] synonym: "negative regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051956 ! negative regulation of amino acid transport relationship: negatively_regulates GO:0051933 ! amino acid uptake involved in synaptic transmission [Term] id: GO:0051943 name: positive regulation of amino acid uptake involved in synaptic transmission namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] synonym: "activation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "positive regulation of amino acid neurotransmitter reuptake" EXACT [] synonym: "positive regulation of amino acid neurotransmitter uptake" EXACT [] synonym: "stimulation of amino acid uptake during transmission of nerve impulse" NARROW [] synonym: "up regulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "up-regulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "upregulation of amino acid uptake during transmission of nerve impulse" RELATED [] is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051957 ! positive regulation of amino acid transport relationship: positively_regulates GO:0051933 ! amino acid uptake involved in synaptic transmission [Term] id: GO:0051944 name: positive regulation of catecholamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of catecholamine uptake during transmission of nerve impulse" NARROW [] synonym: "positive regulation of catecholamine neurotransmitter reuptake" EXACT [] synonym: "positive regulation of catecholamine neurotransmitter uptake" EXACT [] synonym: "positive regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb] synonym: "stimulation of catecholamine uptake during transmission of nerve impulse" NARROW [] synonym: "up regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "up-regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "upregulation of catecholamine uptake during transmission of nerve impulse" EXACT [] is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission is_a: GO:0051954 ! positive regulation of amine transport relationship: positively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission [Term] id: GO:0051945 name: negative regulation of catecholamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "down-regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "downregulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "inhibition of catecholamine uptake during transmission of nerve impulse" NARROW [] synonym: "negative regulation of catecholamine neurotransmitter reuptake" EXACT [] synonym: "negative regulation of catecholamine neurotransmitter uptake" EXACT [] synonym: "negative regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission is_a: GO:0051953 ! negative regulation of amine transport relationship: negatively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission [Term] id: GO:0051946 name: regulation of glutamate uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] synonym: "regulation of glutamate reuptake" EXACT [] synonym: "regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "regulation of L-glutamate reuptake" EXACT [] synonym: "regulation of L-glutamate uptake during transmission of nerve impulse" EXACT [] is_a: GO:0002036 ! regulation of L-glutamate transport is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission relationship: regulates GO:0051935 ! glutamate uptake involved in synaptic transmission [Term] id: GO:0051947 name: regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] synonym: "regulation of 4-aminobutyrate reuptake" EXACT [] synonym: "regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] synonym: "regulation of GABA reuptake" EXACT [] synonym: "regulation of GABA uptake during transmission of nerve impulse" EXACT [] synonym: "regulation of gamma-aminobutyric acid reuptake" EXACT [] synonym: "regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission relationship: regulates GO:0051936 ! gamma-aminobutyric acid uptake involved in synaptic transmission [Term] id: GO:0051948 name: negative regulation of glutamate uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] synonym: "down regulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "down-regulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "downregulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "inhibition of glutamate uptake during transmission of nerve impulse" NARROW [] synonym: "negative regulation of glutamate reuptake" EXACT [] synonym: "negative regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0002037 ! negative regulation of L-glutamate transport is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse relationship: negatively_regulates GO:0051935 ! glutamate uptake involved in synaptic transmission [Term] id: GO:0051949 name: negative regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] synonym: "down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] synonym: "negative regulation of 4-aminobutyrate reuptake" EXACT [] synonym: "negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] synonym: "negative regulation of GABA reuptake" EXACT [] synonym: "negative regulation of GABA uptake during transmission of nerve impulse" EXACT [] synonym: "negative regulation of gamma-aminobutyric acid reuptake" EXACT [] synonym: "negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse relationship: negatively_regulates GO:0051936 ! gamma-aminobutyric acid uptake involved in synaptic transmission [Term] id: GO:0051950 name: positive regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] synonym: "activation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] synonym: "positive regulation of 4-aminobutyrate reuptake" EXACT [] synonym: "positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] synonym: "positive regulation of GABA reuptake" EXACT [] synonym: "positive regulation of GABA uptake during transmission of nerve impulse" EXACT [] synonym: "positive regulation of gamma-aminobutyric acid reuptake" EXACT [] synonym: "positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] synonym: "up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse relationship: positively_regulates GO:0051936 ! gamma-aminobutyric acid uptake involved in synaptic transmission [Term] id: GO:0051951 name: positive regulation of glutamate uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] synonym: "activation of glutamate uptake during transmission of nerve impulse" NARROW [] synonym: "positive regulation of glutamate reuptake" EXACT [] synonym: "positive regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of glutamate uptake during transmission of nerve impulse" NARROW [] synonym: "up regulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "up-regulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "upregulation of glutamate uptake during transmission of nerve impulse" EXACT [] is_a: GO:0002038 ! positive regulation of L-glutamate transport is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse relationship: positively_regulates GO:0051935 ! glutamate uptake involved in synaptic transmission [Term] id: GO:0051952 name: regulation of amine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0015837 ! amine transport [Term] id: GO:0051953 name: negative regulation of amine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amine transport" EXACT [] synonym: "down-regulation of amine transport" EXACT [] synonym: "downregulation of amine transport" EXACT [] synonym: "inhibition of amine transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051952 ! regulation of amine transport relationship: negatively_regulates GO:0015837 ! amine transport [Term] id: GO:0051954 name: positive regulation of amine transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amine transport" NARROW [] synonym: "stimulation of amine transport" NARROW [] synonym: "up regulation of amine transport" EXACT [] synonym: "up-regulation of amine transport" EXACT [] synonym: "upregulation of amine transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051952 ! regulation of amine transport relationship: positively_regulates GO:0015837 ! amine transport [Term] id: GO:0051955 name: regulation of amino acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051952 ! regulation of amine transport relationship: regulates GO:0006865 ! amino acid transport [Term] id: GO:0051956 name: negative regulation of amino acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amino acid transport" EXACT [] synonym: "down-regulation of amino acid transport" EXACT [] synonym: "downregulation of amino acid transport" EXACT [] synonym: "inhibition of amino acid transport" NARROW [] synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport relationship: negatively_regulates GO:0006865 ! amino acid transport [Term] id: GO:0051957 name: positive regulation of amino acid transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amino acid transport" NARROW [] synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah] synonym: "stimulation of amino acid transport" NARROW [] synonym: "up regulation of amino acid transport" EXACT [] synonym: "up-regulation of amino acid transport" EXACT [] synonym: "upregulation of amino acid transport" EXACT [] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport relationship: positively_regulates GO:0006865 ! amino acid transport [Term] id: GO:0051958 name: methotrexate transport namespace: biological_process def: "The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport [Term] id: GO:0051959 name: dynein light intermediate chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light intermediate chain of the dynein complex." [GOC:bf] is_a: GO:0045502 ! dynein binding [Term] id: GO:0051960 name: regulation of nervous system development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0007399 ! nervous system development [Term] id: GO:0051961 name: negative regulation of nervous system development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "down regulation of nervous system development" EXACT [] synonym: "down-regulation of nervous system development" EXACT [] synonym: "downregulation of nervous system development" EXACT [] synonym: "inhibition of nervous system development" NARROW [] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051960 ! regulation of nervous system development relationship: negatively_regulates GO:0007399 ! nervous system development [Term] id: GO:0051962 name: positive regulation of nervous system development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "activation of nervous system development" NARROW [] synonym: "stimulation of nervous system development" NARROW [] synonym: "up regulation of nervous system development" EXACT [] synonym: "up-regulation of nervous system development" EXACT [] synonym: "upregulation of nervous system development" EXACT [] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051960 ! regulation of nervous system development relationship: positively_regulates GO:0007399 ! nervous system development [Term] id: GO:0051963 name: regulation of synaptogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptogenesis, the formation of a synapse." [GOC:ai] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0050807 ! regulation of synapse organization is_a: GO:0051960 ! regulation of nervous system development relationship: regulates GO:0007416 ! synapse assembly [Term] id: GO:0051964 name: negative regulation of synaptogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptogenesis, the formation of a synapse." [GOC:ai] synonym: "down regulation of synaptogenesis" EXACT [] synonym: "down-regulation of synaptogenesis" EXACT [] synonym: "downregulation of synaptogenesis" EXACT [] synonym: "inhibition of synaptogenesis" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:0051963 ! regulation of synaptogenesis relationship: negatively_regulates GO:0007416 ! synapse assembly [Term] id: GO:0051965 name: positive regulation of synaptogenesis namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptogenesis, the formation of a synapse." [GOC:ai] synonym: "activation of synaptogenesis" NARROW [] synonym: "stimulation of synaptogenesis" NARROW [] synonym: "up regulation of synaptogenesis" EXACT [] synonym: "up-regulation of synaptogenesis" EXACT [] synonym: "upregulation of synaptogenesis" EXACT [] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:0051963 ! regulation of synaptogenesis relationship: positively_regulates GO:0007416 ! synapse assembly [Term] id: GO:0051966 name: regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] is_a: GO:0050804 ! regulation of synaptic transmission relationship: regulates GO:0035249 ! synaptic transmission, glutamatergic [Term] id: GO:0051967 name: negative regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] synonym: "down regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "downregulation of synaptic transmission, glutamatergic" EXACT [] synonym: "inhibition of synaptic transmission, glutamatergic" NARROW [] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic relationship: negatively_regulates GO:0035249 ! synaptic transmission, glutamatergic [Term] id: GO:0051968 name: positive regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] synonym: "activation of synaptic transmission, glutamatergic" NARROW [] synonym: "stimulation of synaptic transmission, glutamatergic" NARROW [] synonym: "up regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "upregulation of synaptic transmission, glutamatergic" EXACT [] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic relationship: positively_regulates GO:0035249 ! synaptic transmission, glutamatergic [Term] id: GO:0051969 name: regulation of transmission of nerve impulse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0031644 ! regulation of neurological system process relationship: regulates GO:0019226 ! transmission of nerve impulse [Term] id: GO:0051970 name: negative regulation of transmission of nerve impulse namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "down regulation of transmission of nerve impulse" EXACT [] synonym: "down-regulation of transmission of nerve impulse" EXACT [] synonym: "downregulation of transmission of nerve impulse" EXACT [] synonym: "inhibition of transmission of nerve impulse" NARROW [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0031645 ! negative regulation of neurological system process is_a: GO:0051969 ! regulation of transmission of nerve impulse relationship: negatively_regulates GO:0019226 ! transmission of nerve impulse [Term] id: GO:0051971 name: positive regulation of transmission of nerve impulse namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "activation of transmission of nerve impulse" NARROW [] synonym: "stimulation of transmission of nerve impulse" NARROW [] synonym: "up regulation of transmission of nerve impulse" EXACT [] synonym: "up-regulation of transmission of nerve impulse" EXACT [] synonym: "upregulation of transmission of nerve impulse" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0031646 ! positive regulation of neurological system process is_a: GO:0051969 ! regulation of transmission of nerve impulse relationship: positively_regulates GO:0019226 ! transmission of nerve impulse [Term] id: GO:0051972 name: regulation of telomerase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [EC:2.-.-.-, GOC:ai] synonym: "telomerase regulator" EXACT [] is_a: GO:0051338 ! regulation of transferase activity [Term] id: GO:0051973 name: positive regulation of telomerase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai] synonym: "activation of telomerase activity" NARROW [] synonym: "stimulation of telomerase activity" NARROW [] synonym: "telomerase activator" RELATED [] synonym: "up regulation of telomerase activity" EXACT [] synonym: "up-regulation of telomerase activity" EXACT [] synonym: "upregulation of telomerase activity" EXACT [] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:0051972 ! regulation of telomerase activity [Term] id: GO:0051974 name: negative regulation of telomerase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai] synonym: "down regulation of telomerase activity" EXACT [] synonym: "down-regulation of telomerase activity" EXACT [] synonym: "downregulation of telomerase activity" EXACT [] synonym: "inhibition of telomerase activity" NARROW [] synonym: "telomerase inhibitor" RELATED [] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:0051972 ! regulation of telomerase activity [Term] id: GO:0051975 name: lysine biosynthetic process via alpha-aminoadipate and saccharopine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine." [MetaCyc:LYSINE-AMINOAD-PWY] synonym: "lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [] synonym: "lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [] xref: MetaCyc:LYSINE-AMINOAD-PWY is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid [Term] id: GO:0051976 name: lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine." [MetaCyc:PWY-3081] synonym: "lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT [] synonym: "lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT [] xref: MetaCyc:PWY-3081 is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid [Term] id: GO:0051977 name: lysophospholipid transport namespace: biological_process def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai] is_a: GO:0015914 ! phospholipid transport [Term] id: GO:0051978 name: lysophospholipid transporter activity namespace: molecular_function def: "Enables the directed movement of lysophospholipids into, out of or within a cell, or between cells. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai] subset: gosubset_prok is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0051979 name: alginic acid acetylation namespace: biological_process def: "The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate." [GOC:mlg] synonym: "alginate acetylation" EXACT [] is_a: GO:0042120 ! alginic acid metabolic process [Term] id: GO:0051980 name: iron-nicotianamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other." [GOC:ai] synonym: "Fe-NA chelate transporter activity" EXACT [] is_a: GO:0015603 ! iron chelate transmembrane transporter activity [Term] id: GO:0051981 name: copper chelate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com] subset: gosubset_prok is_a: GO:0005375 ! copper ion transmembrane transporter activity [Term] id: GO:0051982 name: copper-nicotianamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other." [GOC:ai] synonym: "Cu-NA chelate transporter activity" EXACT [] is_a: GO:0051981 ! copper chelate transmembrane transporter activity [Term] id: GO:0051983 name: regulation of chromosome segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007059 ! chromosome segregation [Term] id: GO:0051984 name: positive regulation of chromosome segregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "activation of chromosome segregation" NARROW [] synonym: "stimulation of chromosome segregation" NARROW [] synonym: "up regulation of chromosome segregation" EXACT [] synonym: "up-regulation of chromosome segregation" EXACT [] synonym: "upregulation of chromosome segregation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051983 ! regulation of chromosome segregation relationship: positively_regulates GO:0007059 ! chromosome segregation [Term] id: GO:0051985 name: negative regulation of chromosome segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "down regulation of chromosome segregation" EXACT [] synonym: "down-regulation of chromosome segregation" EXACT [] synonym: "downregulation of chromosome segregation" EXACT [] synonym: "inhibition of chromosome segregation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051983 ! regulation of chromosome segregation relationship: negatively_regulates GO:0007059 ! chromosome segregation [Term] id: GO:0051986 name: negative regulation of attachment of spindle microtubules to kinetochore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] synonym: "down regulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "down-regulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "downregulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "inhibition of attachment of spindle microtubules to kinetochore" NARROW [] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore relationship: negatively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore [Term] id: GO:0051987 name: positive regulation of attachment of spindle microtubules to kinetochore namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] synonym: "activation of attachment of spindle microtubules to kinetochore" NARROW [] synonym: "stimulation of attachment of spindle microtubules to kinetochore" NARROW [] synonym: "up regulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "up-regulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "upregulation of attachment of spindle microtubules to kinetochore" EXACT [] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore relationship: positively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore [Term] id: GO:0051988 name: regulation of attachment of spindle microtubules to kinetochore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] synonym: "regulation of kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: regulates GO:0008608 ! attachment of spindle microtubules to kinetochore [Term] id: GO:0051989 name: coproporphyrinogen dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine." [EC:1.3.99.22] synonym: "coproporphyrinogen III oxidase activity" EXACT [EC:1.3.99.22] synonym: "coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.22] synonym: "HemN" RELATED [EC:1.3.99.22] synonym: "oxygen-independent coproporphyrinogen-III oxidase activity" EXACT [] synonym: "radical SAM enzyme activity" RELATED [EC:1.3.99.22] xref: EC:1.3.99.22 xref: MetaCyc:HEMN-RXN is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0051990 name: (R)-2-hydroxyglutarate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] subset: gosubset_prok synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT [] xref: EC:1.1.1.- xref: Reactome:263886 "(R)-2-hydroxyglutarate dehydrogenase activity" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0051991 name: UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP." [MetaCyc:NACGLCTRANS-RXN] comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227. subset: gosubset_prok xref: EC:2.4.1.227 xref: MetaCyc:NACGLCTRANS-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0051992 name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13, MetaCyc:PHOSNACMURPENTATRANS-RXN] comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. subset: gosubset_prok xref: EC:2.7.8.13 xref: MetaCyc:PHOSNACMURPENTATRANS-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0051993 name: abscisic acid glucose ester beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose." [PMID:16990135] synonym: "ABA-GE beta-glucosidase activity" EXACT [] is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0051994 name: P-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0051995 name: Se-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0051996 name: squalene synthase activity namespace: molecular_function def: "Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate." [EC:2.5.1.21] comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. subset: gosubset_prok synonym: "squalene synthetase activity" EXACT [EC:2.5.1.21] xref: EC:2.5.1.21 xref: MetaCyc:RXN66-281 is_a: GO:0004311 ! farnesyltranstransferase activity [Term] id: GO:0051997 name: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2." [MetaCyc:RXN-6201] synonym: "4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity" EXACT [] synonym: "OHCU decarboxylase activity" EXACT [] xref: EC:4.1.1.- xref: KEGG:R06604 xref: MetaCyc:RXN-6201 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0051998 name: protein carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to a carboxyl group on a protein." [GOC:ai] synonym: "protein carboxyl methyltransferase activity" EXACT [] is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0010340 ! carboxyl-O-methyltransferase activity [Term] id: GO:0051999 name: mannosyl-inositol phosphorylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] synonym: "mannose inositol phosphoceramide biosynthetic process" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) biosynthetic process" EXACT [] synonym: "mannosyl-inositol phosphorylceramide anabolism" EXACT [] synonym: "mannosyl-inositol phosphorylceramide biosynthesis" EXACT [] synonym: "mannosyl-inositol phosphorylceramide formation" EXACT [] synonym: "mannosyl-inositol phosphorylceramide synthesis" EXACT [] synonym: "MIPC biosynthetic process" EXACT [] is_a: GO:0006675 ! mannosyl-inositol phosphorylceramide metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process [Term] id: GO:0052000 name: Type IV pili-dependent aggregation namespace: biological_process def: "The formation of bacterial aggregates in liquid culture dependent on the presence of Type IV pili." [GOC:ml] subset: gosubset_prok synonym: "auto-aggregation" BROAD [] synonym: "bfp-dependent aggregation" EXACT [] synonym: "bundle-forming fimbriae-dependent aggregation" EXACT [] synonym: "bundle-forming pili-dependent aggregation" EXACT [] synonym: "tfp-dependent aggregation" EXACT [] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0052001 name: Type IV pili-dependent localized adherence to host namespace: biological_process def: "Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml] subset: gosubset_prok is_a: GO:0044406 ! adhesion to host [Term] id: GO:0052002 name: metabolism by symbiont of substance in host namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052003 name: negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "negative modulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] synonym: "negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] is_a: GO:0052004 ! negative regulation by symbiont of host salicylic acid-mediated defense response is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway is_a: GO:0052252 ! negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction [Term] id: GO:0052004 name: negative regulation by symbiont of host salicylic acid-mediated defense response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "down-regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "downregulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "inhibition by symbiont of host salicylic acid-mediated defense response" NARROW [] synonym: "negative regulation of host SA-mediated defense response" EXACT [] synonym: "suppression by organism of host salicylic acid-mediated defense response" EXACT [] synonym: "suppression of host SA mediated defense response" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response is_a: GO:0052253 ! negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction relationship: negatively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway [Term] id: GO:0052005 name: negative regulation by symbiont of host ethylene-mediated defense response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "down-regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "downregulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "inhibition by symbiont of host ethylene-mediated defense response" NARROW [] synonym: "suppression by organism of host ethylene-mediated defense response" EXACT [] is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response is_a: GO:0052254 ! negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction [Term] id: GO:0052006 name: catabolism by symbiont of substance in host namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its host resulting in the breakdown of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of substance in host" EXACT [] is_a: GO:0052002 ! metabolism by symbiont of substance in host is_a: GO:0052227 ! catabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052007 name: biosynthesis by symbiont of substance in host namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its host resulting in the formation of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "biosynthesis by organism of substance in host" EXACT [] is_a: GO:0052002 ! metabolism by symbiont of substance in host is_a: GO:0052226 ! biosynthesis of substance in other organism involved in symbiotic interaction [Term] id: GO:0052008 name: disassembly by symbiont of host cellular component namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "catabolism of host cellular component by organism" EXACT [] synonym: "catabolism of host structural constituent by organism" EXACT [] synonym: "degradation of host cellular component by organism" EXACT [] synonym: "disassembly by organism of host cellular component" EXACT [] is_a: GO:0052043 ! modification by symbiont of host cellular component is_a: GO:0052368 ! disassembly by organism of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052009 name: disassembly by symbiont of host cell wall namespace: biological_process def: "The breakdown of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "catabolism of host cell wall by organism" EXACT [] synonym: "degradation of host cell wall by organism" EXACT [] synonym: "disassembly by organism of host cell wall" EXACT [] is_a: GO:0052008 ! disassembly by symbiont of host cellular component is_a: GO:0052020 ! modification by symbiont of host cell wall is_a: GO:0052339 ! disassembly by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052010 name: catabolism by symbiont of host cell wall cellulose namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "catabolism by organism of host cell wall cellulose" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052172 ! metabolism by symbiont of host cell wall cellulose is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction relationship: part_of GO:0052009 ! disassembly by symbiont of host cell wall [Term] id: GO:0052011 name: catabolism by symbiont of host cell wall pectin namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "catabolism by organism of host cell wall pectin" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052179 ! metabolism by symbiont of host cell wall pectin is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction relationship: part_of GO:0052009 ! disassembly by symbiont of host cell wall [Term] id: GO:0052012 name: catabolism by symbiont of host cell wall chitin namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "catabolism by organism of host cell wall chitin" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052178 ! metabolism by symbiont of host cell wall chitin is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction relationship: part_of GO:0052009 ! disassembly by symbiont of host cell wall [Term] id: GO:0052013 name: catabolism by symbiont of host macromolecule namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host macromolecule" EXACT [] is_a: GO:0052006 ! catabolism by symbiont of substance in host is_a: GO:0052174 ! metabolism by symbiont of host macromolecule is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052014 name: catabolism by symbiont of host protein namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host protein" EXACT [] is_a: GO:0052013 ! catabolism by symbiont of host macromolecule is_a: GO:0052228 ! metabolism by symbiont of host protein is_a: GO:0052363 ! catabolism by organism of protein in other organism involved in symbiotic interaction [Term] id: GO:0052015 name: catabolism by symbiont of host carbohydrate namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host carbohydrate" EXACT [] is_a: GO:0052013 ! catabolism by symbiont of host macromolecule is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052016 name: catabolism by symbiont of host glucan namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host glucan" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052176 ! metabolism by symbiont of host glucan is_a: GO:0052359 ! catabolism by organism of glucan in other organism involved in symbiotic interaction [Term] id: GO:0052017 name: catabolism by symbiont of host xylan namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host xylan" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052177 ! metabolism by symbiont of host xylan is_a: GO:0052366 ! catabolism by organism of xylan in other organism involved in symbiotic interaction [Term] id: GO:0052018 name: modulation by symbiont of RNA levels in host namespace: biological_process def: "The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by symbiont of host RNA levels" EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052249 ! modulation of RNA levels in other organism involved in symbiotic interaction [Term] id: GO:0052019 name: modulation by symbiont of host hormone or growth regulator levels namespace: biological_process def: "The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction [Term] id: GO:0052020 name: modification by symbiont of host cell wall namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "metabolism of host cell wall by organism" EXACT [] is_a: GO:0052043 ! modification by symbiont of host cellular component is_a: GO:0052333 ! modification by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052021 name: modulation by symbiont of ethylene levels in host namespace: biological_process def: "The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels is_a: GO:0052449 ! modulation by organism of ethylene levels in other organism involved in symbiotic interaction [Term] id: GO:0052022 name: modulation by symbiont of jasmonic acid levels in host namespace: biological_process def: "The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels is_a: GO:0052456 ! modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction [Term] id: GO:0052023 name: modulation by symbiont of salicylic acid levels in host namespace: biological_process def: "The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels is_a: GO:0052469 ! modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction [Term] id: GO:0052024 name: positive regulation by symbiont of hormone or growth regulator levels in host namespace: biological_process def: "The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of hormone or growth regulator levels in host" NARROW [] synonym: "positive modulation of hormone or growth regulator levels in host" EXACT [] synonym: "stimulation by symbiont of hormone or growth regulator levels in host" NARROW [] synonym: "up regulation by symbiont of hormone or growth regulator levels in host" EXACT [] synonym: "up-regulation by symbiont of hormone or growth regulator levels in host" EXACT [] synonym: "upregulation by symbiont of hormone or growth regulator levels in host" EXACT [] is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels is_a: GO:0052513 ! positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction [Term] id: GO:0052025 name: modification by symbiont of host cell membrane namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the host cell membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052043 ! modification by symbiont of host cellular component is_a: GO:0052332 ! modification by organism of cell membrane in other organism involved in symbiotic interaction [Term] id: GO:0052026 name: modulation by symbiont of host transcription namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of host transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052312 ! modulation of transcription in other organism involved in symbiotic interaction [Term] id: GO:0052027 name: modulation by symbiont of host signal transduction pathway namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by symbiont of host signal transduction" RELATED [] synonym: "modulation of host signal transduction by symbiont" EXACT [] synonym: "regulation by symbiont of host signal transduction pathway" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052250 ! modulation of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052028 name: positive regulation by symbiont of host signal transduction pathway namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host signal transduction pathway" NARROW [] synonym: "stimulation by symbiont of host signal transduction pathway" NARROW [] synonym: "up regulation by symbiont of host signal transduction pathway" EXACT [] synonym: "up-regulation by symbiont of host signal transduction pathway" EXACT [] synonym: "upregulation by symbiont of host signal transduction pathway" EXACT [] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052029 name: negative regulation by symbiont of host signal transduction pathway namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host signal transduction pathway" EXACT [] synonym: "down-regulation by symbiont of host signal transduction pathway" EXACT [] synonym: "downregulation by symbiont of host signal transduction pathway" EXACT [] synonym: "inhibition by symbiont of host signal transduction pathway" NARROW [] synonym: "negative modulation by organism of host signal transduction pathway" EXACT [] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052030 name: induction by symbiont of host apoptosis namespace: biological_process def: "Any process in which an organism activates programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of host apoptosis" EXACT [] synonym: "activation by organism of host apoptotic programmed cell death" EXACT [] synonym: "induction by organism of host apoptotic programmed cell death" EXACT [] is_a: GO:0052044 ! induction by symbiont of host programmed cell death is_a: GO:0052151 ! positive regulation by symbiont of host apoptosis is_a: GO:0052388 ! induction by organism of apoptosis in other organism involved in symbiotic interaction [Term] id: GO:0052031 name: modulation by symbiont of host defense response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052200 ! response to host defenses is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052032 name: modulation by symbiont of host inflammatory response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism involved in symbiotic interaction [Term] id: GO:0052033 name: pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity namespace: biological_process def: "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] subset: gosubset_prok synonym: "general elicitor-dependent activation of host innate immunity" EXACT [] synonym: "general elicitor-dependent induction of host innate immunity" EXACT [] synonym: "MAMP dependent activation of host innate immunity" EXACT [] synonym: "MAMP dependent induction of host innate immunity" EXACT [] synonym: "PAMP dependent activation of host innate immunity" EXACT [] synonym: "PAMP dependent induction of host innate immunity" EXACT [] synonym: "pathogen-associated molecular pattern dependent activation by organism of host innate immunity" EXACT [] is_a: GO:0052166 ! positive regulation by symbiont of host innate immunity is_a: GO:0052169 ! pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity is_a: GO:0052257 ! pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism involved in symbiotic interaction [Term] id: GO:0052034 name: negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immunity namespace: biological_process def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which an organism tops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] subset: gosubset_prok synonym: "down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] synonym: "down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] synonym: "downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] synonym: "inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW [] synonym: "suppression of general elicitor induced host innate immunity" EXACT [] synonym: "suppression of general elicitor-induced host innate immunity" EXACT [] synonym: "suppression of MAMP induced host innate immunity" EXACT [] synonym: "suppression of MAMP-induced host innate immunity" EXACT [] synonym: "suppression of PAMP induced host innate immunity" EXACT [] synonym: "suppression of PAMP-induced host innate immunity" EXACT [] synonym: "suppression of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] is_a: GO:0052157 ! modulation by symbiont of microbe-associated molecular pattern-induced host innate immunity is_a: GO:0052170 ! negative regulation by symbiont of host innate immunity is_a: GO:0052258 ! negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism involved in symbiotic interaction [Term] id: GO:0052035 name: positive regulation by symbiont of host inflammatory response namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host inflammatory response" NARROW [] synonym: "stimulation by symbiont of host inflammatory response" NARROW [] synonym: "up regulation by symbiont of host inflammatory response" EXACT [] synonym: "up-regulation by symbiont of host inflammatory response" EXACT [] synonym: "upregulation by symbiont of host inflammatory response" EXACT [] is_a: GO:0052032 ! modulation by symbiont of host inflammatory response is_a: GO:0052259 ! positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response [Term] id: GO:0052036 name: negative regulation by symbiont of host inflammatory response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host inflammatory response" EXACT [] synonym: "down-regulation by symbiont of host inflammatory response" EXACT [] synonym: "downregulation by symbiont of host inflammatory response" EXACT [] synonym: "inhibition by symbiont of host inflammatory response" NARROW [] is_a: GO:0052032 ! modulation by symbiont of host inflammatory response is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052260 ! negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction [Term] id: GO:0052037 name: negative regulation by symbiont of host defense response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host defense response" EXACT [] synonym: "down-regulation by symbiont of host defense response" EXACT [] synonym: "downregulation by symbiont of host defense response" EXACT [] synonym: "inhibition by symbiont of host defense response" NARROW [] synonym: "suppression of host defense response" EXACT [] is_a: GO:0044414 ! suppression of host defenses is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052038 name: modulation by symbiont of host intracellular transport namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of host intracellular trafficking" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052230 ! modulation of intracellular transport in other organism involved in symbiotic interaction [Term] id: GO:0052039 name: modification by symbiont of host cytoskeleton namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052043 ! modification by symbiont of host cellular component is_a: GO:0052334 ! modification by organism of cytoskeleton of other organism involved in symbiotic interaction [Term] id: GO:0052040 name: modulation by symbiont of host programmed cell death namespace: biological_process alt_id: GO:0052152 def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by symbiont of host non-apoptotic programmed cell death" NARROW [] synonym: "modulation of host PCD" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052041 name: negative regulation by symbiont of host programmed cell death namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host programmed cell death" EXACT [] synonym: "down-regulation by symbiont of host programmed cell death" EXACT [] synonym: "downregulation by symbiont of host programmed cell death" EXACT [] synonym: "inhibition by symbiont of host programmed cell death" NARROW [] synonym: "inhibition of host programmed cell death" EXACT [] synonym: "suppression by symbiont of host PCD" EXACT [] synonym: "suppression by symbiont of host programmed cell death" EXACT [] is_a: GO:0052040 ! modulation by symbiont of host programmed cell death is_a: GO:0052490 ! negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052042 name: positive regulation by symbiont of host programmed cell death namespace: biological_process alt_id: GO:0052153 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host programmed cell death" NARROW [] synonym: "enhancement of host programmed cell death" EXACT [] synonym: "positive regulation by symbiont of host non-apoptotic programmed cell death" NARROW [] synonym: "stimulation by symbiont of host programmed cell death" NARROW [] is_a: GO:0052040 ! modulation by symbiont of host programmed cell death is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction relationship: part_of GO:0001907 ! killing by symbiont of host cells [Term] id: GO:0052043 name: modification by symbiont of host cellular component namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052111 ! modification by symbiont of host structure is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052044 name: induction by symbiont of host programmed cell death namespace: biological_process def: "The activation by an organism of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of host programmed cell death" EXACT [] is_a: GO:0052400 ! induction by organism of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052045 name: upregulation by symbiont of host programmed cell death namespace: biological_process def: "Any process in which an organism increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "enhancement of host programmed cell death by organism" EXACT [] is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death is_a: GO:0052529 ! upregulation by organism of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052046 name: modification by symbiont of host morphology or physiology via secreted substance namespace: biological_process def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by one of the organisms. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modification of host morphology or physiology via effector molecule" NARROW [] synonym: "modification of host morphology or physiology via ellicitor" NARROW [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052047 name: interaction with other organism via secreted substance involved in symbiotic interaction namespace: biological_process def: "An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "interaction with other organism via secreted substance during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044419 ! interspecies interaction between organisms relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0052048 name: interaction with host via secreted substance involved in symbiotic interaction namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "interaction with host via secreted substance during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044046 ! interaction with host via substance released outside of symbiont is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052049 name: interaction with host via protein secreted by type III secretion system namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type III secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction is_a: GO:0052210 ! interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction [Term] id: GO:0052050 name: interaction with host via substance secreted by type IV secretion system namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the other organism by a type IV secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction is_a: GO:0052209 ! interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction [Term] id: GO:0052051 name: interaction with host via protein secreted by type II secretion system namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction is_a: GO:0052211 ! interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction [Term] id: GO:0052052 name: modification by symbiont of host morphology or physiology via protein secreted by type II secretion system namespace: biological_process def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type II secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance is_a: GO:0052051 ! interaction with host via protein secreted by type II secretion system is_a: GO:0052206 ! modification of morphology or physiology of other organism via protein secreted by type II secretion system involved in symbiotic interaction [Term] id: GO:0052053 name: negative regulation by symbiont of host catalytic activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host enzyme activity" EXACT [] synonym: "down-regulation by symbiont of host enzyme activity" EXACT [] synonym: "downregulation by symbiont of host enzyme activity" EXACT [] synonym: "inhibition by symbiont of host enzyme activity" NARROW [] synonym: "inhibition of host enzyme activity" EXACT [] synonym: "negative regulation by symbiont of host enzyme activity" EXACT [] is_a: GO:0052056 ! negative regulation by symbiont of host molecular function is_a: GO:0052148 ! modulation by symbiont of host catalytic activity is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0052054 name: negative regulation by symbiont of host peptidase activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "down regulation by symbiont of host protease activity" EXACT [] synonym: "down-regulation by symbiont of host protease activity" EXACT [] synonym: "downregulation by symbiont of host protease activity" EXACT [] synonym: "inhibition by symbiont of host protease activity" NARROW [] synonym: "inhibition of host protease activity" EXACT [] synonym: "negative regulation by symbiont of host protease activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity is_a: GO:0052149 ! modulation by symbiont of host protease activity is_a: GO:0052180 ! negative regulation of peptidase activity in other organism involved in symbiotic interaction [Term] id: GO:0052055 name: modulation by symbiont of host molecular function namespace: biological_process def: "The process in which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "modification by symbiont of host molecular function" EXACT [] synonym: "modification by symbiont of host protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052056 name: negative regulation by symbiont of host molecular function namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of host proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "down regulation by symbiont of host protein function" EXACT [] synonym: "down-regulation by symbiont of host protein function" EXACT [] synonym: "downregulation by symbiont of host protein function" EXACT [] synonym: "inhibition by symbiont of host protein function" NARROW [] synonym: "inhibition of host protein function" EXACT [] synonym: "negative regulation by symbiont of host protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0052055 ! modulation by symbiont of host molecular function is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052057 name: modification by symbiont of host morphology or physiology via protein secreted by type III secretion system namespace: biological_process def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type III secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance is_a: GO:0052049 ! interaction with host via protein secreted by type III secretion system is_a: GO:0052207 ! modification of morphology or physiology of other organism via protein secreted by type III secretion system involved in symbiotic interaction [Term] id: GO:0052058 name: modification by symbiont of host morphology or physiology via substance secreted by type IV secretion system namespace: biological_process def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type IV secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance is_a: GO:0052050 ! interaction with host via substance secreted by type IV secretion system is_a: GO:0052208 ! modification of morphology or physiology of other organism via substance secreted by type IV secretion system involved in symbiotic interaction [Term] id: GO:0052059 name: evasion or tolerance by symbiont of host-produced reactive oxygen species namespace: biological_process def: "The process in which an organism avoids the effects of reactive oxygen species produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion by organism of cellular damage caused by host oxidative burst" NARROW [] synonym: "evasion or tolerance by organism of host-produced reactive oxygen species" EXACT [] synonym: "evasion or tolerance by organism of reactive oxygen species produced during host defense response" EXACT [] synonym: "evasion or tolerance of defense-related host metabolic burst" EXACT [] synonym: "evasion or tolerance of defense-related host oxidative burst" EXACT [] synonym: "evasion or tolerance of defense-related host respiratory burst" EXACT [] synonym: "evasion or tolerance of host-produced active oxygen species" EXACT [] synonym: "evasion or tolerance of host-produced AOS" EXACT [] synonym: "evasion or tolerance of host-produced reactive oxygen intermediates" EXACT [] synonym: "evasion or tolerance of host-produced ROIs" EXACT [] synonym: "evasion or tolerance of host-produced ROS" EXACT [] synonym: "evasion or tolerance of reactive oxygen species produced by host in response to organism" EXACT [] is_a: GO:0020012 ! evasion or tolerance of host immune response is_a: GO:0052385 ! evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction is_a: GO:0052567 ! response to defense-related host reactive oxygen species production [Term] id: GO:0052060 name: evasion or tolerance by symbiont of host-produced nitric oxide namespace: biological_process def: "The process in which an organism avoids the effects of nitric oxide produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion or tolerance by organism of host nitric oxide" EXACT [] synonym: "evasion or tolerance by organism of host NO" EXACT [] synonym: "evasion or tolerance by organism of host-produced nitric oxide" EXACT [] synonym: "evasion or tolerance by organism of host-produced NO" EXACT [] synonym: "evasion or tolerance of nitric oxide produced by host in response to organism" EXACT [] synonym: "evasion or tolerance of NO produced by host in response to organism" EXACT [] is_a: GO:0020012 ! evasion or tolerance of host immune response is_a: GO:0052376 ! evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction is_a: GO:0052565 ! response to defense-related host nitric oxide production [Term] id: GO:0052061 name: evasion or tolerance by symbiont of host-produced phytoalexins namespace: biological_process def: "The process in which an organism avoids the effects of phytoalexins produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion or tolerance by organism of host phytoalexins" EXACT [] synonym: "evasion or tolerance by organism of host-produced phytoalexins" EXACT [] synonym: "evasion or tolerance of phytoalexins produced by host in response to organism" EXACT [] synonym: "host phytoalexin detoxification" NARROW [] is_a: GO:0020012 ! evasion or tolerance of host immune response is_a: GO:0052378 ! evasion or tolerance by organism of phytoalexins produced by other organism involved in symbiotic interaction is_a: GO:0052566 ! response to host phytoalexin production [Term] id: GO:0052062 name: induction by symbiont of host phytoalexin production namespace: biological_process def: "The activation by an organism of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of host phytoalexin production" EXACT [] is_a: GO:0052262 ! induction by organism of phytoalexin production in other organism involved in symbiotic interaction is_a: GO:0052344 ! positive regulation by symbiont of host phytoalexin production is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052063 name: induction by symbiont of defense-related host nitric oxide production namespace: biological_process def: "The activation by an organism of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related host nitric oxide production" EXACT [] synonym: "activation by organism of defense-related host NO production" EXACT [] synonym: "induction by organism of defense-related host NO production" EXACT [] is_a: GO:0052263 ! induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction is_a: GO:0052347 ! positive regulation by symbiont of defense-related host nitric oxide production is_a: GO:0052509 ! positive regulation by symbiont of host defense response is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052064 name: induction by symbiont of defense-related host reactive oxygen species production namespace: biological_process def: "The activation by an organism of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related host active oxygen species production" EXACT [] synonym: "activation by organism of defense-related host AOS production" EXACT [] synonym: "activation by organism of defense-related host metabolic burst" EXACT [] synonym: "activation by organism of defense-related host oxidative burst" EXACT [] synonym: "activation by organism of defense-related host reactive oxidative species production" EXACT [] synonym: "activation by organism of defense-related host reactive oxygen intermediate production" EXACT [] synonym: "activation by organism of defense-related host reactive oxygen species production" EXACT [] synonym: "activation by organism of defense-related host respiratory burst" EXACT [] synonym: "activation by organism of defense-related host ROI production" EXACT [] synonym: "activation by organism of defense-related host ROS production" EXACT [] synonym: "induction by organism of defense-related host active oxygen species production" EXACT [] synonym: "induction by organism of defense-related host AOS production" EXACT [] synonym: "induction by organism of defense-related host metabolic burst" EXACT [] synonym: "induction by organism of defense-related host oxidative burst" EXACT [] synonym: "induction by organism of defense-related host reactive oxidative species production" EXACT [] synonym: "induction by organism of defense-related host reactive oxygen intermediate production" EXACT [] synonym: "induction by organism of defense-related host respiratory burst" EXACT [] synonym: "induction by organism of defense-related host ROI production" EXACT [] synonym: "induction by organism of defense-related host ROS production" EXACT [] is_a: GO:0052264 ! induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction is_a: GO:0052369 ! positive regulation by symbiont of defense-related host reactive oxygen species production is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052065 name: positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of defense-related Ca2+ flux in other organism during symbiotic interaction" RELATED [] synonym: "positive regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [] is_a: GO:0052301 ! modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052066 name: entry of symbiont into host cell by promotion of host phagocytosis namespace: biological_process def: "The invasion by an organism of a cell of its host organism by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "entry of organism into host cell by promotion of host phagocytosis" EXACT [] is_a: GO:0030260 ! entry into host cell is_a: GO:0052191 ! positive regulation by symbiont of host phagocytosis is_a: GO:0052370 ! entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction [Term] id: GO:0052067 name: negative regulation by symbiont of entry into host cell via phagocytosis namespace: biological_process def: "Any process in which an organism stops or prevents itself undergoing phagocytosis into a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of entry into host cell via phagocytosis" EXACT [] synonym: "down-regulation by symbiont of entry into host cell via phagocytosis" EXACT [] synonym: "downregulation by symbiont of entry into host cell via phagocytosis" EXACT [] synonym: "inhibition by symbiont of entry into host cell via phagocytosis" NARROW [] synonym: "negative regulation by organism of entry into host cell via host phagocytosis" EXACT [] is_a: GO:0044415 ! evasion or tolerance of host defenses is_a: GO:0052374 ! negative regulation by symbiont of entry into host is_a: GO:0052380 ! modulation by symbiont of entry into host via phagocytosis is_a: GO:0052483 ! negative regulation by organism of entry into cell of other organism via phagocytosis involved in symbiotic interaction [Term] id: GO:0052068 name: negative regulation by symbiont of host jasmonic acid-mediated defense response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "down-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "downregulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "inhibition by symbiont of host jasmonic acid-mediated defense response" NARROW [] synonym: "suppression by organism of host JA-mediated defense response" EXACT [] is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response is_a: GO:0052266 ! negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052562 ! negative regulation by symbiont of host immune response [Term] id: GO:0052069 name: negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "down-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "downregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "inhibition by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "negative regulation by organism of defense-related host JA-mediated signal transduction pathway" EXACT [] is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway is_a: GO:0052068 ! negative regulation by symbiont of host jasmonic acid-mediated defense response is_a: GO:0052082 ! modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway is_a: GO:0052267 ! negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052070 name: negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] synonym: "down-regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] synonym: "downregulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] synonym: "inhibition by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW [] synonym: "suppression by organism of defense-related host ethylene-mediated signal transduction pathway" EXACT [] is_a: GO:0052005 ! negative regulation by symbiont of host ethylene-mediated defense response is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway is_a: GO:0052077 ! modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway is_a: GO:0052268 ! negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052071 name: positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW [] synonym: "activation by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW [] synonym: "stimulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW [] synonym: "up regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] synonym: "up-regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW [] synonym: "upregulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway is_a: GO:0052076 ! positive regulation by symbiont of host ethylene-mediated defense response is_a: GO:0052077 ! modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway is_a: GO:0052269 ! positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052072 name: positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway is_a: GO:0052074 ! positive regulation by symbiont of host salicylic acid-mediated defense response is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway is_a: GO:0052270 ! positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052073 name: positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] synonym: "stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway is_a: GO:0052075 ! positive regulation by symbiont of host jasmonic acid-mediated defense response is_a: GO:0052082 ! modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway is_a: GO:0052271 ! positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052074 name: positive regulation by symbiont of host salicylic acid-mediated defense response namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host salicylic acid-mediated defense response" NARROW [] synonym: "induction by organism of host SA-mediated defense response" NARROW [] synonym: "induction by organism of host salicylic acid-mediated defense response" NARROW [] synonym: "positive regulation by organism of host SA-mediated defense response" EXACT [] synonym: "stimulation by symbiont of host salicylic acid-mediated defense response" NARROW [] synonym: "up regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "up-regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "upregulation by symbiont of host salicylic acid-mediated defense response" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response is_a: GO:0052272 ! positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response relationship: positively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway [Term] id: GO:0052075 name: positive regulation by symbiont of host jasmonic acid-mediated defense response namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host jasmonic acid-mediated defense response" NARROW [] synonym: "induction by organism of host JA-mediated defense response" NARROW [] synonym: "induction by organism of host jasmonic acid-mediated defense response" NARROW [] synonym: "positive regulation by organism of host JA-mediated defense response" EXACT [] synonym: "stimulation by symbiont of host jasmonic acid-mediated defense response" NARROW [] synonym: "up regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "up-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "upregulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response is_a: GO:0052273 ! positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response is_a: GO:0052556 ! positive regulation by symbiont of host immune response [Term] id: GO:0052076 name: positive regulation by symbiont of host ethylene-mediated defense response namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of host ethylene-mediated defense response" NARROW [] synonym: "activation by symbiont of host ethylene-mediated defense response" NARROW [] synonym: "induction by organism of host ethylene-mediated defense response" NARROW [] synonym: "stimulation by symbiont of host ethylene-mediated defense response" NARROW [] synonym: "up regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "up-regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "upregulation by organism of host ethylene-mediated defense response" NARROW [] synonym: "upregulation by symbiont of host ethylene-mediated defense response" EXACT [] is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response is_a: GO:0052274 ! positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response [Term] id: GO:0052077 name: modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052078 name: negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "down-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "downregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "negative regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] synonym: "suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway is_a: GO:0052275 ! negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0075132 ! negative regulation by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0052079 name: positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT [] synonym: "positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] synonym: "stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway is_a: GO:0052276 ! positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response is_a: GO:0075131 ! positive regulation by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0052080 name: modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of defense-related host MAPK-mediated signal transduction pathway by organism" EXACT [] synonym: "modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT [] is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0052081 name: modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of defense-related host SA-mediated signal transduction pathway by organism" EXACT [] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052082 name: modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of defense-related host JA-mediated signal transduction pathway by organism" EXACT [] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052083 name: negative regulation by symbiont of host cell-mediated immune response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host cell-mediated immune response" EXACT [] synonym: "down-regulation by symbiont of host cell-mediated immune response" EXACT [] synonym: "downregulation by symbiont of host cell-mediated immune response" EXACT [] synonym: "inhibition by symbiont of host cell-mediated immune response" NARROW [] synonym: "negative regulation by organism of host cell-based immune response" EXACT [] is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response is_a: GO:0052278 ! negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction is_a: GO:0052562 ! negative regulation by symbiont of host immune response [Term] id: GO:0052084 name: modulation by symbiont of host ethylene-mediated defense response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction [Term] id: GO:0052085 name: negative regulation by symbiont of host T-cell mediated immune response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host T-cell mediated immune response" EXACT [] synonym: "down-regulation by symbiont of host T-cell mediated immune response" EXACT [] synonym: "downregulation by symbiont of host T-cell mediated immune response" EXACT [] synonym: "inhibition by symbiont of host T-cell mediated immune response" NARROW [] is_a: GO:0052083 ! negative regulation by symbiont of host cell-mediated immune response is_a: GO:0052156 ! modulation by symbiont of host T-cell mediated immune response is_a: GO:0052280 ! negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction [Term] id: GO:0052086 name: negative regulation by symbiont of host B-cell mediated immune response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host B-cell mediated immune response" EXACT [] synonym: "down-regulation by symbiont of host B-cell mediated immune response" EXACT [] synonym: "downregulation by symbiont of host B-cell mediated immune response" EXACT [] synonym: "inhibition by symbiont of host B-cell mediated immune response" NARROW [] is_a: GO:0052083 ! negative regulation by symbiont of host cell-mediated immune response is_a: GO:0052154 ! modulation by symbiont of host B-cell mediated immune response is_a: GO:0052281 ! negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction [Term] id: GO:0052087 name: negative regulation by symbiont of defense-related host callose deposition namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of callose deposition performed by the host as part of its defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of defense-related host callose deposition" EXACT [] synonym: "down-regulation by symbiont of defense-related host callose deposition" EXACT [] synonym: "downregulation by symbiont of defense-related host callose deposition" EXACT [] synonym: "inhibition by symbiont of defense-related host callose deposition" NARROW [] synonym: "suppression by organism of defense-related host callose deposition" EXACT [] is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition is_a: GO:0052282 ! negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction [Term] id: GO:0052088 name: modulation by symbiont of host jasmonic acid-mediated defense response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of host JA-mediated defense response" EXACT [] is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052089 name: modulation by symbiont of host salicylic acid-mediated defense response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of host SA-mediated defense response" EXACT [] is_a: GO:0010112 ! regulation of systemic acquired resistance is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway relationship: regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway [Term] id: GO:0052090 name: modulation by symbiont of defense-related host callose deposition namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction [Term] id: GO:0052091 name: modulation by symbiont of nutrient release from host namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052313 ! modulation of nutrient release from other organism involved in symbiotic interaction relationship: part_of GO:0044002 ! acquisition of nutrients from host [Term] id: GO:0052092 name: positive regulation by symbiont of nutrient release from host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of nutrient release from host" NARROW [] synonym: "promotion of nutrient release from host" EXACT [] synonym: "stimulation by symbiont of nutrient release from host" NARROW [] synonym: "up regulation by symbiont of nutrient release from host" EXACT [] synonym: "up-regulation by symbiont of nutrient release from host" EXACT [] synonym: "upregulation by symbiont of nutrient release from host" EXACT [] is_a: GO:0052091 ! modulation by symbiont of nutrient release from host is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism involved in symbiotic interaction [Term] id: GO:0052093 name: formation of specialized structure for nutrient acquisition from host namespace: biological_process def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "formation by organism of specialized structure for nutrient acquisition from host" EXACT [] synonym: "formation by symbiont of specialized structure for nutrient acquisition from host" EXACT [] is_a: GO:0044115 ! development of symbiont involved in interaction with host is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction relationship: part_of GO:0044002 ! acquisition of nutrients from host [Term] id: GO:0052094 name: formation by symbiont of haustorium for nutrient acquisition from host namespace: biological_process def: "The assembly by an organism of a haustorium, a projection from a cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.onelook.com] synonym: "formation by organism of haustoria for nutrient acquisition from host" EXACT [] synonym: "formation by organism of haustorium for nutrient acquisition from host" EXACT [] is_a: GO:0044118 ! development of symbiont in host cell is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host [Term] id: GO:0052095 name: formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction namespace: biological_process def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044111 ! development involved in symbiotic interaction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction [Term] id: GO:0052096 name: formation by symbiont of syncytium involving giant cell for nutrient acquisition from host namespace: biological_process def: "The assembly by an organism of a syncytium, a nematode-induced multi-nucleate and physiologically active aggregation of fused root cells which exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "formation by organism of syncytium involving giant cell for nutrient acquisition from host" EXACT [] is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host [Term] id: GO:0052097 name: interspecies quorum sensing namespace: biological_process def: "The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0009372 ! quorum sensing is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0052098 name: formation by host of specialized structure for nutrient acquisition from symbiont namespace: biological_process def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051850 ! acquisition of nutrients from symbiont is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction [Term] id: GO:0052099 name: acquisition by symbiont of nutrients from host via siderophores namespace: biological_process def: "The process that begins with the production and formation of siderophores in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] synonym: "acquisition by organism of nutrients from host via siderophores" EXACT [] is_a: GO:0044002 ! acquisition of nutrients from host [Term] id: GO:0052100 name: intraspecies quorum sensing namespace: biological_process def: "The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0009372 ! quorum sensing is_a: GO:0051703 ! intraspecies interaction between organisms [Term] id: GO:0052101 name: induction by symbiont of host resistance gene-dependent defense response namespace: biological_process def: "The activation by an organism of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense response in host by specific elicitors" EXACT [] synonym: "activation by organism of host gene-for-gene resistance" EXACT [] synonym: "activation by organism of host resistance gene-dependent defense response" EXACT [] synonym: "activation by organism of pathogen-race/host plant cultivar-specific resistance in host" EXACT [] synonym: "induction by organism of defense response in host by specific elicitors" EXACT [] synonym: "induction by organism of host gene-for-gene resistance" EXACT [] synonym: "induction by organism of pathogen-race/host plant cultivar-specific resistance in host" EXACT [] is_a: GO:0052286 ! induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction is_a: GO:0052527 ! positive regulation by symbiont of host resistance gene-dependent defense response is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052102 name: positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW [] synonym: "positive regulation of defense-related host CDPK pathway by organism" EXACT [] synonym: "stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW [] synonym: "up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] synonym: "up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] synonym: "upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] is_a: GO:0052168 ! modulation by symbiont of defense-related host calcium-dependent protein kinase pathway is_a: GO:0052287 ! positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response [Term] id: GO:0052103 name: induction by symbiont of host induced systemic resistance namespace: biological_process def: "Any process in which an organism activates induced systemic resistance in the host; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of induced systemic resistance in host" EXACT [] synonym: "activation by organism of ISR in host" EXACT [] synonym: "induction by organism of ISR in host" EXACT [] synonym: "induction by symbiont of induced systemic resistance in host" EXACT [] is_a: GO:0052288 ! induction by organism of induced systemic resistance in other organism involved in symbiotic interaction is_a: GO:0052390 ! induction by symbiont of host innate immunity is_a: GO:0052533 ! positive regulation by symbiont of host induced systemic resistance [Term] id: GO:0052104 name: induction by symbiont of host systemic acquired resistance namespace: biological_process def: "Any process in which an organism activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of SAR in host" EXACT [] synonym: "activation by organism of systemic acquired resistance in host" EXACT [] synonym: "induction by organism of SAR in host" EXACT [] synonym: "induction by symbiont of systemic acquired resistance in host" EXACT [] is_a: GO:0052289 ! induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction is_a: GO:0052390 ! induction by symbiont of host innate immunity is_a: GO:0052537 ! positive regulation by symbiont of host systemic acquired resistance [Term] id: GO:0052105 name: induction by symbiont of defense-related host cell wall thickening namespace: biological_process def: "The activation by an organism of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related host cell wall thickening" EXACT [] synonym: "activation by organism of host defensive cell wall thickening" EXACT [] synonym: "induction by organism of host defensive cell wall thickening" EXACT [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052290 ! induction by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction is_a: GO:0052539 ! positive regulation by symbiont of defense-related host cell wall thickening [Term] id: GO:0052106 name: quorum sensing involved in interaction with host namespace: biological_process def: "The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "quorum sensing during interaction with host" RELATED [GOC:tb] is_a: GO:0052097 ! interspecies quorum sensing relationship: part_of GO:0051701 ! interaction with host [Term] id: GO:0052107 name: positive regulation by symbiont of defense-related host callose deposition namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of defense-related host callose deposition" NARROW [] synonym: "induction by organism of defense-related host callose deposition" NARROW [] synonym: "induction by organism of defense-related papilla formation in host" NARROW [] synonym: "positive regulation by organism of defense-related papilla formation in host" EXACT [] synonym: "stimulation by symbiont of defense-related host callose deposition" NARROW [] synonym: "up regulation by symbiont of defense-related host callose deposition" EXACT [] synonym: "up-regulation by symbiont of defense-related host callose deposition" EXACT [] synonym: "upregulation by symbiont of defense-related host callose deposition" EXACT [] is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition is_a: GO:0052291 ! positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response [Term] id: GO:0052108 name: growth or development of symbiont during interaction with host namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont during interaction with host ; GO:0044116' and 'development of symbiont during interaction with host ; GO:0044115'. subset: gosubset_prok synonym: "growth or development of organism during interaction with host" EXACT [] synonym: "growth or development of organism in response to host" EXACT [] is_obsolete: true replaced_by: GO:0044115 replaced_by: GO:0044116 [Term] id: GO:0052109 name: positive regulation by symbiont of defense-related host cell wall callose deposition namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of defense-related host cell wall callose deposition" NARROW [] synonym: "induction by organism of defense-related host cell wall callose deposition" NARROW [] synonym: "positive regulation by organism of defense-related host cell wall callose deposition" EXACT [] synonym: "stimulation by symbiont of defense-related host cell wall callose deposition" NARROW [] synonym: "up regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] synonym: "up-regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] synonym: "upregulation by symbiont of defense-related host cell wall callose deposition" EXACT [] is_a: GO:0052107 ! positive regulation by symbiont of defense-related host callose deposition is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition is_a: GO:0052292 ! positive regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction is_a: GO:0052539 ! positive regulation by symbiont of defense-related host cell wall thickening [Term] id: GO:0052110 name: occlusion by symbiont of host vascular system namespace: biological_process def: "The process in which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] subset: gosubset_prok is_a: GO:0052111 ! modification by symbiont of host structure is_a: GO:0052495 ! occlusion by organism of vascular system in other organism involved in symbiotic interaction [Term] id: GO:0052111 name: modification by symbiont of host structure namespace: biological_process def: "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052112 name: occlusion by symbiont of host xylem namespace: biological_process def: "The process in which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052110 ! occlusion by symbiont of host vascular system is_a: GO:0052497 ! occlusion by organism of xylem in other organism involved in symbiotic interaction [Term] id: GO:0052113 name: adaptation to host osmotic environment namespace: biological_process def: "OBSOLETE. The responsive adjustment of an organism to the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was made obsolete because adaptation was not deemed to be a valid biological process. subset: gosubset_prok synonym: "osmotic tolerance to host environment" EXACT [] is_obsolete: true [Term] id: GO:0052114 name: adaptation to host pH environment namespace: biological_process def: "OBSOLETE. The responsive adjustment of an organism to the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was made obsolete because adaptation was not deemed to be a valid biological process. subset: gosubset_prok synonym: "pH tolerance to host environment" EXACT [] is_obsolete: true [Term] id: GO:0052115 name: energy taxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism in the environment of its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "energy taxis in response to host environment" EXACT [] is_a: GO:0052126 ! movement in host environment is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052116 name: chemotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "chemotaxis in response to host environment" EXACT [] is_a: GO:0052126 ! movement in host environment is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052117 name: aerotaxis in host environment namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "aerotaxis in response to host environment" EXACT [] is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052118 name: positive energy taxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism on, within or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive energy taxis in response to host environment" EXACT [] is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052119 name: negative energy taxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative energy taxis in response to host environment" EXACT [] is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052120 name: positive aerotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive aerotaxis in response to host environment" EXACT [] is_a: GO:0052117 ! aerotaxis in host environment is_a: GO:0052118 ! positive energy taxis in host environment is_a: GO:0052121 ! positive chemotaxis in host environment is_a: GO:0052220 ! positive aerotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052121 name: positive chemotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive chemotaxis in response to host environment" EXACT [] is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052122 name: negative aerotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative aerotaxis in response to host environment" EXACT [] is_a: GO:0052117 ! aerotaxis in host environment is_a: GO:0052119 ! negative energy taxis in host environment is_a: GO:0052123 ! negative chemotaxis in host environment is_a: GO:0052222 ! negative aerotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052123 name: negative chemotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative chemotaxis in response to host environment" EXACT [] is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052124 name: energy taxis within host namespace: biological_process def: "The directed movement of a motile cell or organism within its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0044000 ! movement in host is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052125 name: energy taxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism on or near its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052127 ! movement on or near host is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052126 name: movement in host environment namespace: biological_process def: "The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "movement in response to host" EXACT [] is_a: GO:0051701 ! interaction with host is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0052127 name: movement on or near host namespace: biological_process def: "The directed movement of an organism or motile cell on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052126 ! movement in host environment is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction [Term] id: GO:0052128 name: positive energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] is_a: GO:0009453 ! energy taxis [Term] id: GO:0052129 name: negative energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] is_a: GO:0009453 ! energy taxis [Term] id: GO:0052130 name: negative aerotaxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06] is_a: GO:0009454 ! aerotaxis is_a: GO:0050919 ! negative chemotaxis is_a: GO:0052129 ! negative energy taxis [Term] id: GO:0052131 name: positive aerotaxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06] is_a: GO:0009454 ! aerotaxis is_a: GO:0050918 ! positive chemotaxis is_a: GO:0052128 ! positive energy taxis [Term] id: GO:0052132 name: positive aerotaxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052120 ! positive aerotaxis in host environment is_a: GO:0052138 ! aerotaxis on or near host is_a: GO:0052141 ! positive chemotaxis on or near host is_a: GO:0052146 ! positive energy taxis on or near host is_a: GO:0052232 ! positive aerotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052133 name: positive aerotaxis in host namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive aerotaxis within host" EXACT [] is_a: GO:0052120 ! positive aerotaxis in host environment is_a: GO:0052137 ! aerotaxis in host is_a: GO:0052140 ! positive chemotaxis in host is_a: GO:0052147 ! positive energy taxis in host is_a: GO:0052233 ! positive aerotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052134 name: negative aerotaxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052122 ! negative aerotaxis in host environment is_a: GO:0052136 ! negative chemotaxis on or near host is_a: GO:0052138 ! aerotaxis on or near host is_a: GO:0052145 ! negative energy taxis on or near host is_a: GO:0052234 ! negative aerotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052135 name: negative aerotaxis in host namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative aerotaxis within host" EXACT [] is_a: GO:0052122 ! negative aerotaxis in host environment is_a: GO:0052137 ! aerotaxis in host is_a: GO:0052139 ! negative chemotaxis in host is_a: GO:0052144 ! negative energy taxis in host is_a: GO:0052235 ! negative aerotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052136 name: negative chemotaxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052123 ! negative chemotaxis in host environment is_a: GO:0052143 ! chemotaxis on or near host involved in symbiotic interaction is_a: GO:0052236 ! negative chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052137 name: aerotaxis in host namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "aerotaxis within host" EXACT [] is_a: GO:0052117 ! aerotaxis in host environment is_a: GO:0052124 ! energy taxis within host is_a: GO:0052142 ! chemotaxis within host is_a: GO:0052237 ! aerotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052138 name: aerotaxis on or near host namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052117 ! aerotaxis in host environment is_a: GO:0052125 ! energy taxis on or near host is_a: GO:0052143 ! chemotaxis on or near host involved in symbiotic interaction is_a: GO:0052238 ! aerotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052139 name: negative chemotaxis in host namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative chemotaxis within host" EXACT [] is_a: GO:0052123 ! negative chemotaxis in host environment is_a: GO:0052142 ! chemotaxis within host is_a: GO:0052239 ! negative chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052140 name: positive chemotaxis in host namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive chemotaxis within host" EXACT [] is_a: GO:0052121 ! positive chemotaxis in host environment is_a: GO:0052142 ! chemotaxis within host is_a: GO:0052240 ! positive chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052141 name: positive chemotaxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052121 ! positive chemotaxis in host environment is_a: GO:0052143 ! chemotaxis on or near host involved in symbiotic interaction is_a: GO:0052241 ! positive chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052142 name: chemotaxis within host namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0044000 ! movement in host is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052143 name: chemotaxis on or near host involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "chemotaxis on or near host during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052127 ! movement on or near host is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052144 name: negative energy taxis in host namespace: biological_process def: "The directed movement of a motile cell or organism within its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative energy taxis within host" EXACT [] is_a: GO:0052119 ! negative energy taxis in host environment is_a: GO:0052124 ! energy taxis within host is_a: GO:0052244 ! negative energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052145 name: negative energy taxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism on or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052119 ! negative energy taxis in host environment is_a: GO:0052125 ! energy taxis on or near host is_a: GO:0052245 ! negative energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052146 name: positive energy taxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism on or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052118 ! positive energy taxis in host environment is_a: GO:0052125 ! energy taxis on or near host is_a: GO:0052246 ! positive energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052147 name: positive energy taxis in host namespace: biological_process def: "The directed movement of a motile cell or organism within its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive energy taxis within host" EXACT [] is_a: GO:0052118 ! positive energy taxis in host environment is_a: GO:0052124 ! energy taxis within host is_a: GO:0052247 ! positive energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052148 name: modulation by symbiont of host catalytic activity namespace: biological_process def: "The process in which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "modulation by symbiont of host enzyme activity" EXACT [GOC:tb] synonym: "modulation of catalytic activity of host by symbiont" EXACT [] synonym: "regulation by symbiont of host catalytic activity" EXACT [] synonym: "regulation of catalytic activity of host by symbiont" EXACT [] synonym: "regulation of host catalytic activity by symbiont" EXACT [] is_a: GO:0052055 ! modulation by symbiont of host molecular function is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0052149 name: modulation by symbiont of host protease activity namespace: biological_process def: "The process in which an organism effects a change in host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052148 ! modulation by symbiont of host catalytic activity is_a: GO:0052198 ! modulation of protease activity in other organism involved in symbiotic interaction [Term] id: GO:0052150 name: modulation by symbiont of host apoptosis namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'. subset: gosubset_prok synonym: "modulation by organism of host apoptotic programmed cell death" EXACT [] is_a: GO:0052040 ! modulation by symbiont of host programmed cell death is_a: GO:0052433 ! modulation by organism of apoptosis in other organism involved in symbiotic interaction [Term] id: GO:0052151 name: positive regulation by symbiont of host apoptosis namespace: biological_process alt_id: GO:0033669 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of apoptosis ; GO:0043065'. subset: gosubset_prok synonym: "activation by symbiont of host apoptosis" NARROW [] synonym: "positive regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "stimulation by symbiont of host apoptosis" NARROW [] synonym: "up regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "up regulation by symbiont of host apoptosis" EXACT [] synonym: "up-regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "up-regulation by symbiont of host apoptosis" EXACT [] synonym: "upregulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "upregulation by symbiont of host apoptosis" EXACT [] is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death is_a: GO:0052150 ! modulation by symbiont of host apoptosis is_a: GO:0052501 ! positive regulation by organism of apoptosis in other organism involved in symbiotic interaction [Term] id: GO:0052154 name: modulation by symbiont of host B-cell mediated immune response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "regulation by organism of host B-cell mediated immune response" EXACT [] is_a: GO:0052293 ! modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052155 name: modulation by symbiont of host cell-mediated immune response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of host cell-based immune response" EXACT [] is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052156 name: modulation by symbiont of host T-cell mediated immune response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response is_a: GO:0052295 ! modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction [Term] id: GO:0052157 name: modulation by symbiont of microbe-associated molecular pattern-induced host innate immunity namespace: biological_process def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] subset: gosubset_prok synonym: "modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW [] is_a: GO:0052167 ! modulation by symbiont of host innate immunity is_a: GO:0052296 ! modulation by organism of microbe-associated molecular pattern-induced innate immunity in other organism involved in symbiotic interaction [Term] id: GO:0052158 name: modulation by symbiont of host resistance gene-dependent defense response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense response in host by specific elicitors" EXACT [] synonym: "modulation by organism of host gene-for-gene resistance" EXACT [] synonym: "modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] is_a: GO:0052297 ! modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052159 name: modulation by symbiont of host induced systemic resistance namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by symbiont of induced systemic resistance in host" EXACT [] is_a: GO:0052298 ! modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052160 name: modulation by symbiont of host systemic acquired resistance namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by symbiont of systemic acquired resistance in host" EXACT [] is_a: GO:0052299 ! modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052161 name: modulation by symbiont of defense-related host cell wall thickening namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of host defensive cell wall thickening" RELATED [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction [Term] id: GO:0052162 name: modulation by symbiont of defense-related host calcium ion flux namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related host Ca2+ flux" EXACT [] is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052301 ! modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction [Term] id: GO:0052163 name: modulation by symbiont of defense-related host nitric oxide production namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related host NO production" EXACT [] is_a: GO:0052302 ! modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response is_a: GO:0052565 ! response to defense-related host nitric oxide production [Term] id: GO:0052164 name: modulation by symbiont of defense-related host reactive oxygen species production namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related host active oxygen species production" EXACT [] synonym: "modulation by organism of defense-related host AOS production" EXACT [] synonym: "modulation by organism of defense-related host metabolic burst" EXACT [] synonym: "modulation by organism of defense-related host oxidative burst" EXACT [] synonym: "modulation by organism of defense-related host reactive oxidative species production" EXACT [] synonym: "modulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] synonym: "modulation by organism of defense-related host respiratory burst" EXACT [] synonym: "modulation by organism of defense-related host ROI production" EXACT [] synonym: "modulation by organism of defense-related host ROS production" EXACT [] is_a: GO:0052303 ! modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response is_a: GO:0052567 ! response to defense-related host reactive oxygen species production [Term] id: GO:0052165 name: modulation by symbiont of host phytoalexin production namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052304 ! modulation by organism of phytoalexin production in other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response is_a: GO:0052566 ! response to host phytoalexin production [Term] id: GO:0052166 name: positive regulation by symbiont of host innate immunity namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host innate immunity" NARROW [] synonym: "induction of host innate immune response" NARROW [] synonym: "induction of host innate immunity" NARROW [] synonym: "positive regulation of host innate immune response" EXACT [] synonym: "stimulation by symbiont of host innate immunity" NARROW [] synonym: "up regulation by symbiont of host innate immunity" EXACT [] synonym: "up-regulation by symbiont of host innate immunity" EXACT [] synonym: "upregulation by symbiont of host innate immunity" EXACT [] is_a: GO:0052167 ! modulation by symbiont of host innate immunity is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response is_a: GO:0052556 ! positive regulation by symbiont of host immune response [Term] id: GO:0052167 name: modulation by symbiont of host innate immunity namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of host innate immune response" EXACT [] is_a: GO:0052306 ! modulation by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052168 name: modulation by symbiont of defense-related host calcium-dependent protein kinase pathway namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related host CDPK pathway" EXACT [] is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052307 ! modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction [Term] id: GO:0052169 name: pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity namespace: biological_process def: "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] subset: gosubset_prok is_a: GO:0052167 ! modulation by symbiont of host innate immunity is_a: GO:0052308 ! pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism involved in symbiotic interaction [Term] id: GO:0052170 name: negative regulation by symbiont of host innate immunity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host innate immunity" EXACT [] synonym: "down-regulation by symbiont of host innate immunity" EXACT [] synonym: "downregulation by symbiont of host innate immunity" EXACT [] synonym: "inhibition by symbiont of host innate immunity" NARROW [] synonym: "negative regulation of host innate immune response" EXACT [] is_a: GO:0052037 ! negative regulation by symbiont of host defense response is_a: GO:0052167 ! modulation by symbiont of host innate immunity is_a: GO:0052309 ! negative regulation by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052562 ! negative regulation by symbiont of host immune response [Term] id: GO:0052171 name: growth or development during symbiotic interaction namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development during symbiotic interaction ; GO:0044111' and 'growth during symbiotic interaction ; GO:0044110'. subset: gosubset_prok is_obsolete: true replaced_by: GO:0044110 replaced_by: GO:0044111 [Term] id: GO:0052172 name: metabolism by symbiont of host cell wall cellulose namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction [Term] id: GO:0052173 name: response to defenses of other organism involved in symbiotic interaction namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "response to defenses of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051707 ! response to other organism relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0052174 name: metabolism by symbiont of host macromolecule namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052002 ! metabolism by symbiont of substance in host is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052175 name: metabolism by symbiont of host carbohydrate namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052174 ! metabolism by symbiont of host macromolecule is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052176 name: metabolism by symbiont of host glucan namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving glucans within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052415 ! metabolism by organism of glucan in other organism involved in symbiotic interaction [Term] id: GO:0052177 name: metabolism by symbiont of host xylan namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052421 ! metabolism by organism of xylan in other organism involved in symbiotic interaction [Term] id: GO:0052178 name: metabolism by symbiont of host cell wall chitin namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction [Term] id: GO:0052179 name: metabolism by symbiont of host cell wall pectin namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction [Term] id: GO:0052180 name: negative regulation of peptidase activity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "down regulation of protease activity in other organism during symbiotic interaction" EXACT [] synonym: "down-regulation of protease activity in other organism during symbiotic interaction" EXACT [] synonym: "downregulation of protease activity in other organism during symbiotic interaction" EXACT [] synonym: "inhibition of protease activity in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of protease activity in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:0052198 ! modulation of protease activity in other organism involved in symbiotic interaction is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0052181 name: modulation by host of symbiont defense response namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052201 ! response to symbiont defenses is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052182 name: modification by host of symbiont morphology or physiology via secreted substance namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction is_a: GO:0052213 ! interaction with symbiont via secreted substance involved in symbiotic interaction [Term] id: GO:0052183 name: modification by host of symbiont structure namespace: biological_process def: "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052184 name: modulation by organism of symbiont hormone or growth regulator levels namespace: biological_process def: "OBSOLETE. The alteration by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052185 name: modification of structure of other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modification of structure of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052186 name: modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction namespace: biological_process def: "The alteration by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052187 name: modification by host of symbiont cellular component namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a symbiont cellular component. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052183 ! modification by host of symbiont structure is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052188 name: modification of cellular component in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modification of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052189 name: modulation by symbiont of defense-related host cell wall callose deposition namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction [Term] id: GO:0052190 name: modulation by symbiont of host phagocytosis namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052231 ! modulation of phagocytosis in other organism involved in symbiotic interaction [Term] id: GO:0052191 name: positive regulation by symbiont of host phagocytosis namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host phagocytosis" NARROW [] synonym: "stimulation by symbiont of host phagocytosis" NARROW [] synonym: "up regulation by symbiont of host phagocytosis" EXACT [] synonym: "up-regulation by symbiont of host phagocytosis" EXACT [] synonym: "upregulation by symbiont of host phagocytosis" EXACT [] is_a: GO:0052190 ! modulation by symbiont of host phagocytosis is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction [Term] id: GO:0052192 name: movement in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "locomotion in environment of other organism during symbiotic interaction" RELATED [] synonym: "movement in environment of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0040011 ! locomotion relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0052193 name: movement in symbiont environment namespace: biological_process def: "The directed movement of an organism or motile cell on, within or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0051702 ! interaction with symbiont is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0052194 name: movement on or near symbiont namespace: biological_process def: "The directed movement of an organism or motile cell on or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052193 ! movement in symbiont environment is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction [Term] id: GO:0052195 name: movement on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of an organism or motile cell on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "movement on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0052196 name: negative regulation by host of symbiont defense response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by host of symbiont defense response" EXACT [] synonym: "down-regulation by host of symbiont defense response" EXACT [] synonym: "downregulation by host of symbiont defense response" EXACT [] synonym: "inhibition by host of symbiont defense response" NARROW [] is_a: GO:0051859 ! suppression of symbiont defenses is_a: GO:0052181 ! modulation by host of symbiont defense response is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052197 name: positive regulation by host of symbiont defense response namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by host of symbiont defense response" NARROW [] synonym: "stimulation by host of symbiont defense response" NARROW [] synonym: "up regulation by host of symbiont defense response" EXACT [] synonym: "up-regulation by host of symbiont defense response" EXACT [] synonym: "upregulation by host of symbiont defense response" EXACT [] is_a: GO:0052181 ! modulation by host of symbiont defense response is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052198 name: modulation of protease activity in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of protease activity in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0052199 name: negative regulation of catalytic activity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "down regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "downregulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "inhibition of enzyme activity in other organism" EXACT [] synonym: "inhibition of enzyme activity in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of enzyme activity in other organism during symbiotic interaction" EXACT [GOC:tb] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052200 name: response to host defenses namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction is_a: GO:0075136 ! response to host [Term] id: GO:0052201 name: response to symbiont defenses namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0009608 ! response to symbiont is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction [Term] id: GO:0052202 name: negative regulation by symbiont of defense-related host cell wall callose deposition namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] synonym: "down-regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] synonym: "downregulation by symbiont of defense-related host cell wall callose deposition" EXACT [] synonym: "inhibition by symbiont of defense-related host cell wall callose deposition" NARROW [] is_a: GO:0052087 ! negative regulation by symbiont of defense-related host callose deposition is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition is_a: GO:0052311 ! negative regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction [Term] id: GO:0052203 name: modulation of catalytic activity in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "modulation of enzyme activity within other organism during symbiotic interaction" EXACT [GOC:tb] is_a: GO:0050790 ! regulation of catalytic activity is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052204 name: negative regulation of molecular function in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "down regulation of protein function in other organism during symbiotic interaction" EXACT [] synonym: "down-regulation of protein function in other organism during symbiotic interaction" EXACT [] synonym: "downregulation of protein function in other organism during symbiotic interaction" EXACT [] synonym: "inhibition of protein function in other organism" EXACT [] synonym: "inhibition of protein function in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052205 name: modulation of molecular function in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] subset: gosubset_prok synonym: "modification of molecular function in other organism during symbiotic interaction" EXACT [] synonym: "modification of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] synonym: "modulation of molecular function in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0052206 name: modification of morphology or physiology of other organism via protein secreted by type II secretion system involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type II secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052211 ! interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052207 name: modification of morphology or physiology of other organism via protein secreted by type III secretion system involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type III secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052210 ! interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052208 name: modification of morphology or physiology of other organism via substance secreted by type IV secretion system involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type IV secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052209 ! interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052209 name: interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction namespace: biological_process def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type IV secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052210 name: interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction namespace: biological_process def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type III secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "interaction with other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052211 name: interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction namespace: biological_process def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type II secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "interaction with other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052212 name: modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by one of the organisms, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modification of host morphology or physiology via effector molecule" NARROW [] synonym: "modification of host morphology or physiology via ellicitor" NARROW [] synonym: "modification of morphology or physiology of other organism via secreted substance during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052213 name: interaction with symbiont via secreted substance involved in symbiotic interaction namespace: biological_process def: "An interaction with the symbiont organism mediated by a substance secreted by the other (host) organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "interaction with symbiont via secreted substance during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051702 ! interaction with symbiont is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction [Term] id: GO:0052214 name: metabolism of substance in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "metabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044033 ! multi-organism metabolic process is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052215 name: energy taxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in the environment of a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "energy taxis in response to environment of other organism" EXACT [] is_a: GO:0009453 ! energy taxis is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0052216 name: chemotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "chemotaxis in response to environment of other organism" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0007626 ! locomotory behavior is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0052217 name: aerotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "aerotaxis in response to environment of other organism" EXACT [] is_a: GO:0009454 ! aerotaxis is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052218 name: positive energy taxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on, within or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive energy taxis in response to environment of other organism" EXACT [] is_a: GO:0052128 ! positive energy taxis is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052219 name: negative energy taxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative energy taxis in response to environment of other organism" EXACT [] is_a: GO:0052129 ! negative energy taxis is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052220 name: positive aerotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive aerotaxis in response to environment of other organism" EXACT [] is_a: GO:0052131 ! positive aerotaxis is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052221 name: positive chemotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive chemotaxis in response to environment of other organism" EXACT [] is_a: GO:0050918 ! positive chemotaxis is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052222 name: negative aerotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative aerotaxis in response to environment of other organism" EXACT [] is_a: GO:0052130 ! negative aerotaxis is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052223 name: negative chemotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative chemotaxis in response to environment of other organism" EXACT [] is_a: GO:0050919 ! negative chemotaxis is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052224 name: energy taxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism within a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "energy taxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052225 name: energy taxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on or near a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052226 name: biosynthesis of substance in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the formation of substances, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "biosynthesis of substance in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044034 ! multi-organism biosynthetic process is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052227 name: catabolism of substance in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the breakdown of substances, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "catabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044035 ! multi-organism catabolic process is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052228 name: metabolism by symbiont of host protein namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052174 ! metabolism by symbiont of host macromolecule is_a: GO:0052418 ! metabolism by organism of protein in other organism involved in symbiotic interaction [Term] id: GO:0052229 name: metabolism of macromolecule in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism of macromolecule in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052230 name: modulation of intracellular transport in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of intracellular trafficking in other organism" EXACT [] synonym: "modulation of intracellular transport in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052231 name: modulation of phagocytosis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0050764 ! regulation of phagocytosis is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052232 name: positive aerotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052220 ! positive aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052238 ! aerotaxis on or near other organism involved in symbiotic interaction is_a: GO:0052241 ! positive chemotaxis on or near other organism involved in symbiotic interaction is_a: GO:0052246 ! positive energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052233 name: positive aerotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive aerotaxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0052220 ! positive aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052237 ! aerotaxis in other organism involved in symbiotic interaction is_a: GO:0052240 ! positive chemotaxis in other organism involved in symbiotic interaction is_a: GO:0052247 ! positive energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052234 name: negative aerotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052222 ! negative aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052236 ! negative chemotaxis on or near other organism involved in symbiotic interaction is_a: GO:0052238 ! aerotaxis on or near other organism involved in symbiotic interaction is_a: GO:0052245 ! negative energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052235 name: negative aerotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative aerotaxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0052222 ! negative aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052237 ! aerotaxis in other organism involved in symbiotic interaction is_a: GO:0052239 ! negative chemotaxis in other organism involved in symbiotic interaction is_a: GO:0052244 ! negative energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052236 name: negative chemotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052237 name: aerotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "aerotaxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052238 name: aerotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052239 name: negative chemotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative chemotaxis within other organism during symbiotic interaction" RELATED [] is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052240 name: positive chemotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive chemotaxis within other organism during symbiotic interaction" RELATED [] is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052241 name: positive chemotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052242 name: chemotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "chemotaxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052243 name: chemotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052244 name: negative energy taxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism within a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative energy taxis within other organism during symbiotic interaction" RELATED [] is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052245 name: negative energy taxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "negative energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052246 name: positive energy taxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052247 name: positive energy taxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism within a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "positive energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive energy taxis within other organism during symbiotic interaction" RELATED [] is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052248 name: modulation of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process alt_id: GO:0052459 def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "modulation of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052249 name: modulation of RNA levels in other organism involved in symbiotic interaction namespace: biological_process def: "The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of RNA levels in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052250 name: modulation of signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, occurring in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052251 name: induction by organism of defense response of other organism involved in symbiotic interaction namespace: biological_process def: "The activation by an organism of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] subset: gosubset_prok synonym: "activation of defense response of other organism" EXACT [] synonym: "induction by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052252 name: negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" NARROW [] synonym: "negative modulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT [] synonym: "negative modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" EXACT [] synonym: "negative regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT [] synonym: "negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052253 ! negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052253 name: negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "negative regulation of SA-mediated defense response of other organism" EXACT [] synonym: "suppression by organism of salicylic acid-mediated defense response of other organism" EXACT [] synonym: "suppression of SA mediated defense response of other organism" EXACT [] is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction [Term] id: GO:0052254 name: negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "suppression by organism of ethylene-mediated defense response of other organism" EXACT [] is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction [Term] id: GO:0052255 name: modulation by organism of defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the defense response of a second organism, the response mounted by that organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0031347 ! regulation of defense response is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction [Term] id: GO:0052256 name: modulation by organism of inflammatory response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052257 name: pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism involved in symbiotic interaction namespace: biological_process def: "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah] subset: gosubset_prok synonym: "general elicitor dependent induction of innate immunity of other organism" EXACT [] synonym: "general elicitor-dependent induction of innate immunity of other organism" EXACT [] synonym: "MAMP dependent induction of innate immunity of other organism" EXACT [] synonym: "MAMP-dependent induction of innate immunity of other organism" EXACT [] synonym: "PAMP dependent induction of innate immunity of other organism" EXACT [] synonym: "PAMP-dependent induction of innate immunity of other organism" EXACT [] synonym: "pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052308 ! pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism involved in symbiotic interaction [Term] id: GO:0052258 name: negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism involved in symbiotic interaction namespace: biological_process def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah] subset: gosubset_prok synonym: "down regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "suppression of general elicitor induced innate immunity of other organism" EXACT [] synonym: "suppression of general elicitor-induced innate immunity of other organism" EXACT [] synonym: "suppression of MAMP induced innate immunity of other organism" EXACT [] synonym: "suppression of MAMP-induced innate immunity of other organism" EXACT [] synonym: "suppression of PAMP induced innate immunity of other organism" EXACT [] synonym: "suppression of PAMP-induced innate immunity of other organism" EXACT [] synonym: "suppression of pathogen-associated molecular pattern-induced innate immunity of other organism" EXACT [] is_a: GO:0052296 ! modulation by organism of microbe-associated molecular pattern-induced innate immunity in other organism involved in symbiotic interaction is_a: GO:0052309 ! negative regulation by organism of innate immunity in other organism involved in symbiotic interaction [Term] id: GO:0052259 name: positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of inflammatory response of other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of inflammatory response of other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [] is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052260 name: negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of inflammatory response of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism involved in symbiotic interaction is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052261 name: negative regulation by organism of defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of defense response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of defense response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of defense response of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of defense response of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "suppression of defense response of other organism" EXACT [] is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0051833 ! suppression of defenses of other organism involved in symbiotic interaction is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052262 name: induction by organism of phytoalexin production in other organism involved in symbiotic interaction namespace: biological_process def: "The activation by an organism of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [] synonym: "induction by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052329 ! positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052263 name: induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction namespace: biological_process def: "The activation by an organism of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related nitric oxide production in other organism" EXACT [] synonym: "activation by organism of defense-related NO production in other organism" EXACT [] synonym: "induction by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "induction by organism of defense-related NO production in other organism" EXACT [] is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052345 ! positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052264 name: induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction namespace: biological_process def: "The activation by an organism of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related active oxygen species production in other organism" EXACT [] synonym: "activation by organism of defense-related AOS production in other organism" EXACT [] synonym: "activation by organism of defense-related metabolic burst in other organism" EXACT [] synonym: "activation by organism of defense-related oxidative burst in other organism" EXACT [] synonym: "activation by organism of defense-related reactive oxidative species production in other organism" EXACT [] synonym: "activation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT [] synonym: "activation by organism of defense-related reactive oxygen species production in other organism" EXACT [] synonym: "activation by organism of defense-related respiratory burst in other organism" EXACT [] synonym: "activation by organism of defense-related ROI production in other organism" EXACT [] synonym: "activation by organism of defense-related ROS production in other organism" EXACT [] synonym: "induction by organism of defense-related active oxygen species production in other organism" EXACT [] synonym: "induction by organism of defense-related AOS production in other organism" EXACT [] synonym: "induction by organism of defense-related metabolic burst in other organism" EXACT [] synonym: "induction by organism of defense-related oxidative burst in other organism" EXACT [] synonym: "induction by organism of defense-related reactive oxidative species production in other organism" EXACT [] synonym: "induction by organism of defense-related reactive oxygen intermediate production in other organism" EXACT [] synonym: "induction by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "induction by organism of defense-related respiratory burst in other organism" EXACT [] synonym: "induction by organism of defense-related ROI production in other organism" EXACT [] synonym: "induction by organism of defense-related ROS production in other organism" EXACT [] is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052348 ! positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052265 name: induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction namespace: biological_process def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of Ca2+ flux of other organism" EXACT [] synonym: "activation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [] synonym: "induction by organism of Ca2+ flux of other organism" EXACT [] synonym: "induction by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052065 ! positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052266 name: negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "suppression by organism of JA-mediated defense response of other organism" EXACT [] is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction [Term] id: GO:0052267 name: negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of defense-related JA-mediated signal transduction pathway in other organism" EXACT [] synonym: "negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052266 ! negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052268 name: negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052254 ! negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052269 name: positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] synonym: "positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] is_a: GO:0052274 ! positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052270 name: positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] synonym: "activation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW [] synonym: "activation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] synonym: "induction by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW [] synonym: "positive regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] synonym: "positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] synonym: "upregulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW [] synonym: "upregulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] is_a: GO:0052272 ! positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052271 name: positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW [] synonym: "activation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "activation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] synonym: "induction by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW [] synonym: "induction by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] synonym: "positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT [] synonym: "stimulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW [] synonym: "upregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] is_a: GO:0052273 ! positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052272 name: positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of SA-mediated defense response of other organism" NARROW [] synonym: "induction by organism of salicylic acid-mediated defense response of other organism" NARROW [] synonym: "positive regulation by organism of SA-mediated defense response of other organism" EXACT [] synonym: "positive regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052273 name: positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of JA-mediated defense response of other organism" NARROW [] synonym: "induction by organism of jasmonic acid-mediated defense response of other organism" NARROW [] synonym: "positive regulation by organism of JA-mediated defense response of other organism" EXACT [] synonym: "positive regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [] is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052274 name: positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of ethylene-mediated defense response of other organism" NARROW [] synonym: "activation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of ethylene-mediated defense response of other organism" NARROW [] synonym: "positive regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of ethylene-mediated defense response of other organism" NARROW [] synonym: "upregulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [] is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052275 name: negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "negative regulation by organism of defense-related MAPK-mediated signal transduction pathway in other organism" EXACT [] synonym: "negative regulation by organism of defense-related mitogen-activated protein kinase-mediated signal transduction pathway in other organism" EXACT [] is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052276 name: positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] synonym: "activation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] synonym: "positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive regulation by organism of defense-related MAPK-mediated signal transduction pathway in other organism" EXACT [] synonym: "positive regulation by organism of defense-related mitogen-activated protein kinase-mediated signal transduction pathway in other organism" EXACT [] synonym: "stimulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] synonym: "upregulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [] is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052277 name: modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation of defense-related MAPK-mediated signal transduction pathway of other organism" EXACT [] synonym: "modulation of defense-related mitogen activated protein kinase-mediated signal transduction pathway of other organism" EXACT [] is_a: GO:0052250 ! modulation of signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052278 name: negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of cell-mediated immune response of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of cell-based immune response of other organism during symbiotic interaction" RELATED [] synonym: "negative regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction is_a: GO:0052561 ! negative regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052279 name: modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052280 name: negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of T-cell mediated immune response of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052278 ! negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction is_a: GO:0052295 ! modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction [Term] id: GO:0052281 name: negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of B-cell mediated immune response of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052293 ! modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction is_a: GO:0052561 ! negative regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052282 name: negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "suppression by organism of defense-related callose deposition of other organism" EXACT [] is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction [Term] id: GO:0052283 name: modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of JA-mediated defense response of other organism" EXACT [] synonym: "modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052284 name: modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of SA-mediated defense response of other organism" EXACT [] synonym: "modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052285 name: modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related callose deposition of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052286 name: induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction namespace: biological_process def: "The activation by an organism of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense response of other organism by specific elicitors" EXACT [] synonym: "activation by organism of gene-for-gene resistance in other organism" EXACT [] synonym: "activation by organism of resistance gene-dependent defense response of other organism" EXACT [] synonym: "induction by organism of defense response of other organism by specific elicitors" EXACT [] synonym: "induction by organism of gene-for-gene resistance in other organism" EXACT [] synonym: "induction by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052423 ! positive regulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052287 name: positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of calcium-dependent protein kinase pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive regulation by organism of defense-related CDPK pathway of other organism" RELATED [] synonym: "stimulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" RELATED [] is_a: GO:0050850 ! positive regulation of calcium-mediated signaling is_a: GO:0052307 ! modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052288 name: induction by organism of induced systemic resistance in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [] synonym: "activation by organism of ISR in other organism" EXACT [] synonym: "induction by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "induction by organism of ISR in other organism" EXACT [] is_a: GO:0052382 ! induction by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052532 ! positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction [Term] id: GO:0052289 name: induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of SAR in other organism" EXACT [] synonym: "activation by organism of systemic acquired resistance in other organism" EXACT [] synonym: "induction by organism of SAR in other organism" EXACT [] synonym: "induction by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052382 ! induction by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052535 ! positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction [Term] id: GO:0052290 name: induction by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction namespace: biological_process def: "The activation by an organism of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [] synonym: "activation by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED [] synonym: "induction by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "induction by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED [] is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction [Term] id: GO:0052291 name: positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of defense-related callose deposition of other organism" NARROW [] synonym: "induction by organism of defense-related papilla formation in other organism" NARROW [] synonym: "positive regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "positive regulation by organism of defense-related papilla formation in other organism" EXACT [] synonym: "stimulation by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT [] synonym: "up-regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT [] synonym: "upregulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT [] is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052292 name: positive regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the deposition by a second organism of callose in its cell walls, occurring as part of the defense response, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of defense-related cell wall callose deposition in other organism" NARROW [] synonym: "positive regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [] is_a: GO:0052291 ! positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction [Term] id: GO:0052293 name: modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "regulation by organism of B-cell mediated immune response of other organism" EXACT [] is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052294 name: modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of cell-based immune response of other organism during symbiotic interaction" RELATED [] synonym: "modulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052295 name: modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction [Term] id: GO:0052296 name: modulation by organism of microbe-associated molecular pattern-induced innate immunity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah] synonym: "modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism involved in symbiotic interaction" NARROW [] is_a: GO:0052306 ! modulation by organism of innate immunity in other organism involved in symbiotic interaction [Term] id: GO:0052297 name: modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense response in other organism by specific elicitors" EXACT [] synonym: "modulation by organism of gene-for-gene resistance in other organism" EXACT [] synonym: "modulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052298 name: modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0052306 ! modulation by organism of innate immunity in other organism involved in symbiotic interaction [Term] id: GO:0052299 name: modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0010112 ! regulation of systemic acquired resistance is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052300 name: modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED [] is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052301 name: modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related Ca2+ flux in other organism during symbiotic interaction" EXACT [] synonym: "modulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052302 name: modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation by organism of defense-related NO production in other organism during symbiotic interaction" RELATED [] is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism involved in symbiotic interaction is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052303 name: modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related active oxygen species production in other organism" EXACT [] synonym: "modulation by organism of defense-related AOS production in other organism" EXACT [] synonym: "modulation by organism of defense-related metabolic burst in other organism" EXACT [] synonym: "modulation by organism of defense-related oxidative burst in other organism" EXACT [] synonym: "modulation by organism of defense-related reactive oxidative species production in other organism" EXACT [] synonym: "modulation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT [] synonym: "modulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation by organism of defense-related respiratory burst in other organism" EXACT [] synonym: "modulation by organism of defense-related ROI production in other organism" EXACT [] synonym: "modulation by organism of defense-related ROS production in other organism" EXACT [] is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052304 name: modulation by organism of phytoalexin production in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052549 ! response to phytoalexin production by other organism involved in symbiotic interaction is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052305 name: positive regulation by organism of innate immunity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of innate immunity in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "positive regulation of innate immune response of other organism" EXACT [] synonym: "stimulation by organism of innate immunity in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [] is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0052306 ! modulation by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052306 name: modulation by organism of innate immunity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of innate immunity in other organism involved in symbiotic interaction" RELATED [GOC:dph] synonym: "modulation of innate immune response of other organism" EXACT [] is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052307 name: modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of calcium-dependent protein kinase signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction " RELATED [GOC:dph] synonym: "modulation by organism of defense-related CDPK pathway in other organism during symbiotic interaction" EXACT [] is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052308 name: pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah] synonym: "pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052306 ! modulation by organism of innate immunity in other organism involved in symbiotic interaction [Term] id: GO:0052309 name: negative regulation by organism of innate immunity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of innate immunity in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "negative regulation of innate immune response of other organism" EXACT [] is_a: GO:0052261 ! negative regulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052306 ! modulation by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052561 ! negative regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052310 name: modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction [Term] id: GO:0052311 name: negative regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052282 ! negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction [Term] id: GO:0052312 name: modulation of transcription in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of transcription in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052313 name: modulation of nutrient release from other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation of nutrient release from other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction [Term] id: GO:0052314 name: phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin] subset: goslim_pir subset: gosubset_prok synonym: "phytoalexin metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0052315 name: phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin] synonym: "phytoalexin biosynthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052316 name: phytoalexin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai] synonym: "phytoalexin catabolism" EXACT [] is_a: GO:0044248 ! cellular catabolic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052317 name: camalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving camalexin, an indole phytoalexin." [GOC:ai] synonym: "camalexin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046217 ! indole phytoalexin metabolic process [Term] id: GO:0052318 name: regulation of phytoalexin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai] synonym: "regulation of phytoalexin metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052319 name: regulation of phytoalexin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai] synonym: "regulation of phytoalexin biosynthesis" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0052318 ! regulation of phytoalexin metabolic process relationship: regulates GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0052320 name: positive regulation of phytoalexin metabolic process namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:mtg_pamgo_17jul06] synonym: "activation of phytoalexin metabolism" NARROW [] synonym: "positive regulation of phytoalexin metabolism" RELATED [] synonym: "stimulation of phytoalexin metabolism" NARROW [] synonym: "up regulation of phytoalexin metabolism" EXACT [] synonym: "up-regulation of phytoalexin metabolism" EXACT [] synonym: "upregulation of phytoalexin metabolism" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0052318 ! regulation of phytoalexin metabolic process relationship: positively_regulates GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052321 name: negative regulation of phytoalexin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:ai] synonym: "down regulation of phytoalexin metabolism" EXACT [] synonym: "down-regulation of phytoalexin metabolism" EXACT [] synonym: "downregulation of phytoalexin metabolism" EXACT [] synonym: "inhibition of phytoalexin metabolism" NARROW [] synonym: "negative regulation of phytoalexin metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0052318 ! regulation of phytoalexin metabolic process relationship: negatively_regulates GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052322 name: positive regulation of phytoalexin biosynthetic process namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:mtg_pamgo_17jul06] synonym: "activation of phytoalexin biosynthesis" NARROW [] synonym: "positive regulation of phytoalexin biosynthesis" EXACT [] synonym: "stimulation of phytoalexin biosynthesis" NARROW [] synonym: "up regulation of phytoalexin biosynthesis" EXACT [] synonym: "up-regulation of phytoalexin biosynthesis" EXACT [] synonym: "upregulation of phytoalexin biosynthesis" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process is_a: GO:0052320 ! positive regulation of phytoalexin metabolic process relationship: positively_regulates GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0052323 name: negative regulation of phytoalexin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai] synonym: "down regulation of phytoalexin biosynthesis" EXACT [] synonym: "down-regulation of phytoalexin biosynthesis" EXACT [] synonym: "downregulation of phytoalexin biosynthesis" EXACT [] synonym: "inhibition of phytoalexin biosynthesis" NARROW [] synonym: "negative regulation of phytoalexin biosynthesis" EXACT [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process is_a: GO:0052321 ! negative regulation of phytoalexin metabolic process relationship: negatively_regulates GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0052324 name: cell wall cellulose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:ai] synonym: "cell wall cellulose biosynthesis" EXACT [] synonym: "cellulose biosynthesis during cell wall biosynthesis" RELATED [] is_a: GO:0030244 ! cellulose biosynthetic process is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process relationship: part_of GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0052325 name: cell wall pectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai] synonym: "cell wall pectin biosynthesis" EXACT [] synonym: "pectin biosynthesis during cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045489 ! pectin biosynthetic process is_a: GO:0052546 ! cell wall pectin metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process relationship: part_of GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0052326 name: interaction with symbiont via protein secreted by type IV secretion system namespace: biological_process def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type IV secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052327 name: interaction with symbiont via protein secreted by type II secretion system namespace: biological_process def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type II secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052328 name: interaction with symbiont via protein secreted by type III secretion system namespace: biological_process def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type III secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052329 name: positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of phytoalexin production in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of phytoalexin production in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [] is_a: GO:0052304 ! modulation by organism of phytoalexin production in other organism involved in symbiotic interaction is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052330 name: positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process alt_id: GO:0052518 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0051712 ! positive regulation of killing of cells of other organism is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction relationship: positively_regulates GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0052331 name: hemolysis in other organism involved in symbiotic interaction namespace: biological_process def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another, where two organisms are in a symbiotic interaction." [GOC:add, SP_KW:KW-0354] subset: gosubset_prok synonym: "haemolysis in other organism" EXACT [] synonym: "hemolysin activity" RELATED [] synonym: "hemolysis by organism of erythrocytes in other organism during symbiotic interaction" RELATED [] synonym: "hemolysis by organism of RBCs in other organism during symbiotic interaction" RELATED [CL:0000232] synonym: "hemolysis by organism of red blood cells in other organism during symbiotic interaction" RELATED [CL:0000232] synonym: "hemolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "hemolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] is_a: GO:0044179 ! hemolysis in other organism is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction [Term] id: GO:0052332 name: modification by organism of cell membrane in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the cell membrane of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modification by organism of cell membrane in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052333 name: modification by organism of cell wall of other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "metabolism by organism of cell wall of other organism" RELATED [] synonym: "modification by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052334 name: modification by organism of cytoskeleton of other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modification by organism of cytoskeleton of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052335 name: modification by host of symbiont cytoskeleton namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052187 ! modification by host of symbiont cellular component is_a: GO:0052334 ! modification by organism of cytoskeleton of other organism involved in symbiotic interaction [Term] id: GO:0052336 name: modification by host of symbiont cell wall namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "metabolism of symbiont cell wall by organism" EXACT [] is_a: GO:0052187 ! modification by host of symbiont cellular component is_a: GO:0052333 ! modification by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052337 name: modification by host of symbiont cell membrane namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the symbiont cell membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052187 ! modification by host of symbiont cellular component is_a: GO:0052332 ! modification by organism of cell membrane in other organism involved in symbiotic interaction [Term] id: GO:0052338 name: disassembly by host of symbiont cell wall namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism of symbiont cell wall by organism" EXACT [] synonym: "degradation of symbiont cell wall by organism" EXACT [] is_a: GO:0052336 ! modification by host of symbiont cell wall is_a: GO:0052339 ! disassembly by organism of cell wall of other organism involved in symbiotic interaction is_a: GO:0052367 ! disassembly by host of symbiont cellular component [Term] id: GO:0052339 name: disassembly by organism of cell wall of other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "disassembly by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052333 ! modification by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052340 name: catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "catabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0030245 ! cellulose catabolic process is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction is_a: GO:0070910 ! cell wall macromolecule catabolic process involved in cell wall disassembly relationship: part_of GO:0044278 ! cell wall disassembly in other organism relationship: part_of GO:0052339 ! disassembly by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052341 name: catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "catabolism by organism of cell wall pectin in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction is_a: GO:0070910 ! cell wall macromolecule catabolic process involved in cell wall disassembly relationship: part_of GO:0044278 ! cell wall disassembly in other organism relationship: part_of GO:0052339 ! disassembly by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052342 name: catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "catabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0006039 ! cell wall chitin catabolic process is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction relationship: part_of GO:0052339 ! disassembly by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052343 name: positive regulation by organism of symbiont phytoalexin production namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052344 name: positive regulation by symbiont of host phytoalexin production namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host phytoalexin production" NARROW [] synonym: "stimulation by symbiont of host phytoalexin production" NARROW [] synonym: "up regulation by symbiont of host phytoalexin production" EXACT [] synonym: "up-regulation by symbiont of host phytoalexin production" EXACT [] synonym: "upregulation by symbiont of host phytoalexin production" EXACT [] is_a: GO:0052165 ! modulation by symbiont of host phytoalexin production is_a: GO:0052329 ! positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction is_a: GO:0052556 ! positive regulation by symbiont of host immune response [Term] id: GO:0052345 name: positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "positive regulation by organism of defense-related NO production in other organism during symbiotic interaction" RELATED [] synonym: "stimulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED [] is_a: GO:0052302 ! modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052346 name: positive regulation by organism of defense-related symbiont nitric oxide production namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense-related symbiont NO production" EXACT [] is_obsolete: true [Term] id: GO:0052347 name: positive regulation by symbiont of defense-related host nitric oxide production namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of defense-related host nitric oxide production" NARROW [] synonym: "positive regulation by organism of defense-related host NO production" EXACT [] synonym: "stimulation by symbiont of defense-related host nitric oxide production" NARROW [] synonym: "up regulation by symbiont of defense-related host nitric oxide production" EXACT [] synonym: "up-regulation by symbiont of defense-related host nitric oxide production" EXACT [] synonym: "upregulation by symbiont of defense-related host nitric oxide production" EXACT [] is_a: GO:0052163 ! modulation by symbiont of defense-related host nitric oxide production is_a: GO:0052345 ! positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction is_a: GO:0052556 ! positive regulation by symbiont of host immune response [Term] id: GO:0052348 name: positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of defense-related active oxygen species production in other organism" EXACT [] synonym: "positive regulation by organism of defense-related AOS production in other organism" EXACT [] synonym: "positive regulation by organism of defense-related metabolic burst in other organism" EXACT [] synonym: "positive regulation by organism of defense-related oxidative burst in other organism" EXACT [] synonym: "positive regulation by organism of defense-related reactive oxidative species production in other organism" EXACT [] synonym: "positive regulation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT [] synonym: "positive regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "positive regulation by organism of defense-related respiratory burst in other organism" EXACT [] synonym: "positive regulation by organism of defense-related ROI production in other organism" EXACT [] synonym: "positive regulation by organism of defense-related ROS production in other organism" EXACT [] synonym: "stimulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED [] is_a: GO:0052303 ! modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052349 name: positive regulation by organism of defense-related symbiont reactive oxygen species production namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense-related symbiont active oxygen species production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont AOS production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont metabolic burst" EXACT [] synonym: "positive regulation by organism of defense-related symbiont oxidative burst" EXACT [] synonym: "positive regulation by organism of defense-related symbiont reactive oxidative species production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont respiratory burst" EXACT [] synonym: "positive regulation by organism of defense-related symbiont ROI production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont ROS production" EXACT [] is_obsolete: true [Term] id: GO:0052350 name: induction by organism of induced systemic resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process in which an organism activates induced systemic resistance in the symbiont; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of induced systemic resistance in symbiont" EXACT [] synonym: "activation by organism of ISR in symbiont" EXACT [] synonym: "induction by organism of ISR in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052351 name: induction by organism of systemic acquired resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process in which an organism activates systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of SAR in symbiont" EXACT [] synonym: "activation by organism of systemic acquired resistance in symbiont" EXACT [] synonym: "induction by organism of SAR in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052352 name: biosynthesis by host of substance in symbiont namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the formation of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052226 ! biosynthesis of substance in other organism involved in symbiotic interaction is_a: GO:0052419 ! metabolism by host of substance in symbiont [Term] id: GO:0052353 name: catabolism by host of symbiont carbohydrate namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052360 ! catabolism by host of symbiont macromolecule is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate [Term] id: GO:0052354 name: catabolism by organism of carbohydrate in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044041 ! multi-organism carbohydrate catabolic process is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052355 name: catabolism by host of symbiont cell wall cellulose namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052408 ! metabolism by host of symbiont cell wall cellulose relationship: part_of GO:0052338 ! disassembly by host of symbiont cell wall [Term] id: GO:0052356 name: catabolism by host of symbiont cell wall chitin namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052410 ! metabolism by host of symbiont cell wall chitin relationship: part_of GO:0052338 ! disassembly by host of symbiont cell wall [Term] id: GO:0052357 name: catabolism by host of symbiont cell wall pectin namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052412 ! metabolism by host of symbiont cell wall pectin relationship: part_of GO:0052338 ! disassembly by host of symbiont cell wall [Term] id: GO:0052358 name: catabolism by host of symbiont glucan namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052359 ! catabolism by organism of glucan in other organism involved in symbiotic interaction is_a: GO:0052414 ! metabolism by host of symbiont glucan [Term] id: GO:0052359 name: catabolism by organism of glucan in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052415 ! metabolism by organism of glucan in other organism involved in symbiotic interaction [Term] id: GO:0052360 name: catabolism by host of symbiont macromolecule namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction is_a: GO:0052364 ! catabolism by host of substance in symbiont is_a: GO:0052416 ! metabolism by host of symbiont macromolecule [Term] id: GO:0052361 name: catabolism by organism of macromolecule in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of macromolecule in other organism during symbiotic interaction" RELATED [goc:dph] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0052227 ! catabolism of substance in other organism involved in symbiotic interaction is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052362 name: catabolism by host of symbiont protein namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052360 ! catabolism by host of symbiont macromolecule is_a: GO:0052363 ! catabolism by organism of protein in other organism involved in symbiotic interaction is_a: GO:0052417 ! metabolism by host of symbiont protein [Term] id: GO:0052363 name: catabolism by organism of protein in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0030163 ! protein catabolic process is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction is_a: GO:0052418 ! metabolism by organism of protein in other organism involved in symbiotic interaction [Term] id: GO:0052364 name: catabolism by host of substance in symbiont namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the breakdown of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052227 ! catabolism of substance in other organism involved in symbiotic interaction is_a: GO:0052419 ! metabolism by host of substance in symbiont [Term] id: GO:0052365 name: catabolism by host of symbiont xylan namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052366 ! catabolism by organism of xylan in other organism involved in symbiotic interaction is_a: GO:0052420 ! metabolism by host of symbiont xylan [Term] id: GO:0052366 name: catabolism by organism of xylan in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0045493 ! xylan catabolic process is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052421 ! metabolism by organism of xylan in other organism involved in symbiotic interaction [Term] id: GO:0052367 name: disassembly by host of symbiont cellular component namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism of symbiont cellular component by organism" EXACT [] synonym: "catabolism of symbiont structural constituent by organism" EXACT [] synonym: "degradation of symbiont cellular component by organism" EXACT [] is_a: GO:0052187 ! modification by host of symbiont cellular component is_a: GO:0052368 ! disassembly by organism of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052368 name: disassembly by organism of cellular component in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] subset: gosubset_prok synonym: "catabolism of cellular component in other organism" EXACT [] synonym: "catabolism of structural constituent in other organism" EXACT [] synonym: "degradation of cellular component in other organism" EXACT [] synonym: "disassembly by organism of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052369 name: positive regulation by symbiont of defense-related host reactive oxygen species production namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of defense-related host reactive oxygen species production" NARROW [] synonym: "positive regulation by organism of defense-related host active oxygen species production" EXACT [] synonym: "positive regulation by organism of defense-related host AOS production" EXACT [] synonym: "positive regulation by organism of defense-related host metabolic burst" EXACT [] synonym: "positive regulation by organism of defense-related host oxidative burst" EXACT [] synonym: "positive regulation by organism of defense-related host reactive oxidative species production" EXACT [] synonym: "positive regulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] synonym: "positive regulation by organism of defense-related host respiratory burst" EXACT [] synonym: "positive regulation by organism of defense-related host ROI production" EXACT [] synonym: "positive regulation by organism of defense-related host ROS production" EXACT [] synonym: "stimulation by symbiont of defense-related host reactive oxygen species production" NARROW [] synonym: "up regulation by symbiont of defense-related host reactive oxygen species production" EXACT [] synonym: "up-regulation by symbiont of defense-related host reactive oxygen species production" EXACT [] synonym: "upregulation by symbiont of defense-related host reactive oxygen species production" EXACT [] is_a: GO:0052164 ! modulation by symbiont of defense-related host reactive oxygen species production is_a: GO:0052348 ! positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction is_a: GO:0052509 ! positive regulation by symbiont of host defense response is_a: GO:0052556 ! positive regulation by symbiont of host immune response [Term] id: GO:0052370 name: entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction namespace: biological_process def: "The invasion by an organism of a cell of a second organism by utilizing the second organism's phagocytosis mechanism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0051806 ! entry into cell of other organism involved in symbiotic interaction is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction [Term] id: GO:0052371 name: regulation by organism of entry into other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism relationship: regulates GO:0051828 ! entry into other organism involved in symbiotic interaction [Term] id: GO:0052372 name: modulation by symbiont of entry into host namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0052373 name: negative regulation by organism of entry into other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of entry into other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0052374 name: negative regulation by symbiont of entry into host namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of entry into host" EXACT [] synonym: "down-regulation by symbiont of entry into host" EXACT [] synonym: "downregulation by symbiont of entry into host" EXACT [] synonym: "inhibition by symbiont of entry into host" NARROW [] is_a: GO:0052372 ! modulation by symbiont of entry into host is_a: GO:0052373 ! negative regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0052375 name: evasion or tolerance by organism of symbiont-produced nitric oxide namespace: biological_process def: "OBSOLETE. The process by which an organism avoids the effects of nitric oxide produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "evasion or tolerance by organism of symbiont nitric oxide" EXACT [] synonym: "evasion or tolerance by organism of symbiont NO" EXACT [] synonym: "evasion or tolerance by organism of symbiont-produced NO" EXACT [] synonym: "evasion or tolerance of nitric oxide produced by symbiont in response to organism" EXACT [] synonym: "evasion or tolerance of NO produced by symbiont in response to organism" EXACT [] is_obsolete: true [Term] id: GO:0052376 name: evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism avoids the effects of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion or tolerance by organism of nitric oxide produced by other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "evasion or tolerance by organism of NO produced by other organism during symbiotic interaction" RELATED [] synonym: "evasion or tolerance by organism of other organism-produced nitric oxide" RELATED [] synonym: "evasion or tolerance by organism of other organism-produced NO" RELATED [] is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism involved in symbiotic interaction [Term] id: GO:0052377 name: evasion or tolerance by organism of symbiont-produced phytoalexins namespace: biological_process def: "OBSOLETE. The process by which an organism avoids the effects of phytoalexins produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "evasion or tolerance by organism of symbiont phytoalexins" EXACT [] synonym: "evasion or tolerance of phytoalexins produced by symbiont in response to organism" EXACT [] synonym: "symbiont phytoalexin detoxification" NARROW [] is_obsolete: true [Term] id: GO:0052378 name: evasion or tolerance by organism of phytoalexins produced by other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism avoids the effects of phytoalexins produced as a defense response by the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion or tolerance by organism of phytoalexins produced by other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "evasion or tolerance of other organism phytoalexins" EXACT [] synonym: "evasion or tolerance of phytoalexins produced by other organism" EXACT [] synonym: "phytoalexin detoxification" NARROW [] is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction is_a: GO:0052549 ! response to phytoalexin production by other organism involved in symbiotic interaction [Term] id: GO:0052379 name: modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into a second organism via the phagocytotic processes of the other organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of entry into other organism via other organism phagocytosis during symbiotic interaction" RELATED [] synonym: "modulation by organism of entry into other organism via phagocytosis during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0052380 name: modulation by symbiont of entry into host via phagocytosis namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host, via the phagocytotic processes of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of entry into host via host phagocytosis" EXACT [] is_a: GO:0052372 ! modulation by symbiont of entry into host is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction [Term] id: GO:0052381 name: tRNA dimethylallyltransferase activity namespace: molecular_function alt_id: GO:0004811 def: "Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine." [EC:2.5.1.75] comment: Note that this activity was formerly know in GO and EC as 'tRNA isopentenyltransferase' (EC 2.5.1.8, GO:0004811), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate. synonym: "dimethylallyl-diphosphate:tRNA dimethylallyltransferase activity" EXACT systematic_synonym [EC:2.5.1.75] synonym: "tRNA isopentenyltransferase activity" RELATED [GOC:mah, GOC:vw] synonym: "tRNA prenyltransferase activity" BROAD [EC:2.5.1.75] xref: EC:2.5.1.75 xref: MetaCyc:RXN0-6274 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0052382 name: induction by organism of innate immunity in other organism involved in symbiotic interaction namespace: biological_process def: "The activation by an organism of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of innate immune response in other organism involved in symbiotic interaction" EXACT [] synonym: "activation by organism of innate immunity in other organism involved in symbiotic interaction" EXACT [] synonym: "induction by organism of innate immune response in other organism involved in symbiotic interaction" EXACT [] synonym: "induction by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052383 name: induction by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. The activation by an organism of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont innate immune response" EXACT [] synonym: "activation by organism of symbiont innate immunity" EXACT [] synonym: "induction by organism of symbiont innate immune response" EXACT [] is_obsolete: true [Term] id: GO:0052384 name: evasion or tolerance by organism of symbiont-produced reactive oxygen species namespace: biological_process def: "OBSOLETE. The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "evasion by organism of cellular damage caused by symbiont oxidative burst" NARROW [] synonym: "evasion or tolerance by organism of reactive oxygen species produced during symbiont defense response" EXACT [] synonym: "evasion or tolerance of defense-related symbiont metabolic burst" EXACT [] synonym: "evasion or tolerance of defense-related symbiont oxidative burst" EXACT [] synonym: "evasion or tolerance of defense-related symbiont respiratory burst" EXACT [] synonym: "evasion or tolerance of reactive oxygen species produced by symbiont in response to organism" EXACT [] synonym: "evasion or tolerance of symbiont-produced active oxygen species" EXACT [] synonym: "evasion or tolerance of symbiont-produced AOS" EXACT [] synonym: "evasion or tolerance of symbiont-produced reactive oxygen intermediates" EXACT [] synonym: "evasion or tolerance of symbiont-produced ROIs" EXACT [] synonym: "evasion or tolerance of symbiont-produced ROS" EXACT [] is_obsolete: true [Term] id: GO:0052385 name: evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism avoids the effects of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion by organism of cellular damage caused by oxidative burst of other organism" NARROW [] synonym: "evasion or tolerance by organism of defense-related metabolic burst in other organism during symbiotic interaction" RELATED [] synonym: "evasion or tolerance by organism of defense-related oxidative burst in other organism during symbiotic interaction" RELATED [] synonym: "evasion or tolerance by organism of defense-related respiratory burst in other organism during symbiotic interaction" EXACT [] synonym: "evasion or tolerance by organism of reactive oxygen species produced by other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "evasion or tolerance by organism of reactive oxygen species produced during defense response of other organism" RELATED [] synonym: "evasion or tolerance of active oxygen species produced by other organism" EXACT [] synonym: "evasion or tolerance of AOS produced by other organism" EXACT [] synonym: "evasion or tolerance of reactive oxygen intermediates produced by other organism" EXACT [] synonym: "evasion or tolerance of reactive oxygen species produced by other organism" EXACT [] synonym: "evasion or tolerance of ROIs produced by other organism" EXACT [] synonym: "evasion or tolerance of ROS produced by other organism" EXACT [] is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction [Term] id: GO:0052386 name: cell wall thickening namespace: biological_process def: "A type of cell wall modification in which the cell wall is reinforced and made thicker." [GOC:mtg_pamgo_17jul06] is_a: GO:0042545 ! cell wall modification [Term] id: GO:0052387 name: induction by organism of symbiont apoptosis namespace: biological_process def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont apoptosis" EXACT [] synonym: "activation by organism of symbiont apoptotic programmed cell death" EXACT [] synonym: "induction by organism of symbiont apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052388 name: induction by organism of apoptosis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of apoptosis in other organism during symbiotic interaction" RELATED [] synonym: "activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "induction by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "induction by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED [] is_a: GO:0052400 ! induction by organism of programmed cell death in other organism involved in symbiotic interaction is_a: GO:0052501 ! positive regulation by organism of apoptosis in other organism involved in symbiotic interaction [Term] id: GO:0052389 name: positive regulation by symbiont of defense-related host calcium ion flux namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of defense-related host calcium ion flux" NARROW [] synonym: "positive regulation by organism of defense-related host Ca2+ flux" EXACT [] synonym: "stimulation by symbiont of defense-related host calcium ion flux" NARROW [] synonym: "up regulation by symbiont of defense-related host calcium ion flux" EXACT [] synonym: "up-regulation by symbiont of defense-related host calcium ion flux" EXACT [] synonym: "upregulation by symbiont of defense-related host calcium ion flux" EXACT [] is_a: GO:0052065 ! positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction is_a: GO:0052162 ! modulation by symbiont of defense-related host calcium ion flux is_a: GO:0052509 ! positive regulation by symbiont of host defense response [Term] id: GO:0052390 name: induction by symbiont of host innate immunity namespace: biological_process def: "The activation by an organism of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of host innate immune response" EXACT [] synonym: "activation by organism of host innate immunity" EXACT [] synonym: "induction by organism of host innate immune response" RELATED [] is_a: GO:0052166 ! positive regulation by symbiont of host innate immunity is_a: GO:0052382 ! induction by organism of innate immunity in other organism involved in symbiotic interaction is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052391 name: induction by symbiont of defense-related host calcium ion flux namespace: biological_process def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of host Ca2+ flux" EXACT [] synonym: "activation by organism of host calcium ion flux" EXACT [] synonym: "induction by organism of host Ca2+ flux" EXACT [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052265 ! induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction is_a: GO:0052389 ! positive regulation by symbiont of defense-related host calcium ion flux [Term] id: GO:0052392 name: induction by organism of defense-related symbiont calcium ion flux namespace: biological_process def: "OBSOLETE. The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont Ca2+ flux" EXACT [] synonym: "activation by organism of symbiont calcium ion flux" EXACT [] synonym: "induction by organism of symbiont Ca2+ flux" EXACT [] is_obsolete: true [Term] id: GO:0052393 name: induction by host of symbiont defense response namespace: biological_process def: "The activation by an organism of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "activation of symbiont defense response" EXACT [] is_a: GO:0052197 ! positive regulation by host of symbiont defense response is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052394 name: induction by organism of defense-related symbiont cell wall thickening namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont defense-related cell wall thickening" EXACT [] synonym: "activation by organism of symbiont defensive cell wall thickening" EXACT [] synonym: "induction by organism of symbiont defensive cell wall thickening" EXACT [] is_obsolete: true [Term] id: GO:0052395 name: induction by organism of defense-related symbiont nitric oxide production namespace: biological_process def: "OBSOLETE. The activation by an organism of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont nitric acid production" EXACT [] synonym: "activation by organism of defense-related symbiont NO production" EXACT [] synonym: "induction by organism of defense-related symbiont NO production" EXACT [] is_obsolete: true [Term] id: GO:0052396 name: induction by organism of symbiont non-apoptotic programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont non-apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052398 name: induction by organism of symbiont phytoalexin production namespace: biological_process def: "OBSOLETE. The activation by an organism of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont phytoalexin production" EXACT [] is_obsolete: true [Term] id: GO:0052399 name: induction by organism of symbiont programmed cell death namespace: biological_process def: "OBSOLETE. The activation by an organism of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052400 name: induction by organism of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process alt_id: GO:0012504 alt_id: GO:0052397 def: "The activation by an organism of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of non-apoptotic programmed cell death in other organism" NARROW [] synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" EXACT [] synonym: "induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "induction of non-apoptotic programmed cell death by other organism" RELATED [] is_a: GO:0012502 ! induction of programmed cell death is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death [Term] id: GO:0052401 name: induction by organism of defense-related symbiont reactive oxygen species production namespace: biological_process def: "OBSOLETE. The activation by an organism of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont active oxygen species production" EXACT [] synonym: "activation by organism of defense-related symbiont AOS production" EXACT [] synonym: "activation by organism of defense-related symbiont metabolic burst" EXACT [] synonym: "activation by organism of defense-related symbiont oxidative burst" EXACT [] synonym: "activation by organism of defense-related symbiont reactive oxidative species production" EXACT [] synonym: "activation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] synonym: "activation by organism of defense-related symbiont reactive oxygen species production" EXACT [] synonym: "activation by organism of defense-related symbiont respiratory burst" EXACT [] synonym: "activation by organism of defense-related symbiont ROI production" EXACT [] synonym: "activation by organism of defense-related symbiont ROS production" EXACT [] synonym: "induction by organism of defense-related symbiont active oxygen species production" EXACT [] synonym: "induction by organism of defense-related symbiont AOS production" EXACT [] synonym: "induction by organism of defense-related symbiont metabolic burst" EXACT [] synonym: "induction by organism of defense-related symbiont oxidative burst" EXACT [] synonym: "induction by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] synonym: "induction by organism of defense-related symbiont respiratory burst" EXACT [] synonym: "induction by organism of defense-related symbiont ROI production" EXACT [] synonym: "induction by organism of defense-related symbiont ROS production" EXACT [] is_obsolete: true [Term] id: GO:0052402 name: induction by organism of symbiont resistance gene-dependent defense response namespace: biological_process def: "OBSOLETE. The activation by an organism of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense response in symbiont by specific elicitors" EXACT [] synonym: "activation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] synonym: "activation by organism of symbiont gene-for-gene resistance" EXACT [] synonym: "activation by organism of symbiont resistance gene-dependent defense response" EXACT [] synonym: "induction by organism of defense response in symbiont by specific elicitors" EXACT [] synonym: "induction by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] synonym: "induction by organism of symbiont gene-for-gene resistance" EXACT [] is_obsolete: true [Term] id: GO:0052403 name: negative regulation by host of symbiont catalytic activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by host of symbiont enzyme activity" EXACT [] synonym: "down-regulation by host of symbiont enzyme activity" EXACT [] synonym: "downregulation by host of symbiont enzyme activity" EXACT [] synonym: "inhibition by host of symbiont enzyme activity" NARROW [] synonym: "inhibition of symbiont enzyme activity" EXACT [] synonym: "negative regulation by host of symbiont enzyme activity" EXACT [] is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052405 ! negative regulation by host of symbiont molecular function is_a: GO:0052422 ! modulation by host of symbiont catalytic activity [Term] id: GO:0052404 name: negative regulation by host of symbiont peptidase activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation by host of symbiont protease activity" EXACT [] synonym: "down-regulation by host of symbiont protease activity" EXACT [] synonym: "downregulation by host of symbiont protease activity" EXACT [] synonym: "inhibition by host of symbiont protease activity" NARROW [] synonym: "inhibition of symbiont protease activity" EXACT [] synonym: "negative regulation by host of symbiont protease activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0052180 ! negative regulation of peptidase activity in other organism involved in symbiotic interaction is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity is_a: GO:0052427 ! modulation by host of symbiont protease activity [Term] id: GO:0052405 name: negative regulation by host of symbiont molecular function namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of symbiont proteins. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation by host of symbiont protein function" EXACT [] synonym: "down-regulation by host of symbiont protein function" EXACT [] synonym: "downregulation by host of symbiont protein function" EXACT [] synonym: "inhibition by host of symbiont protein function" NARROW [] synonym: "inhibition of symbiont protein function" EXACT [] synonym: "negative regulation by host of symbiont protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction is_a: GO:0052428 ! modification by host of symbiont molecular function [Term] id: GO:0052406 name: metabolism by host of symbiont carbohydrate namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052416 ! metabolism by host of symbiont macromolecule [Term] id: GO:0052407 name: metabolism by organism of carbohydrate in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving carbohydrates within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044040 ! multi-organism carbohydrate metabolic process is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052408 name: metabolism by host of symbiont cell wall cellulose namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction [Term] id: GO:0052409 name: metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process [Term] id: GO:0052410 name: metabolism by host of symbiont cell wall chitin namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction [Term] id: GO:0052411 name: metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0006037 ! cell wall chitin metabolic process is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052412 name: metabolism by host of symbiont cell wall pectin namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction [Term] id: GO:0052413 name: metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of cell wall pectin in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052546 ! cell wall pectin metabolic process [Term] id: GO:0052414 name: metabolism by host of symbiont glucan namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving glucans within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052415 ! metabolism by organism of glucan in other organism involved in symbiotic interaction [Term] id: GO:0052415 name: metabolism by organism of glucan in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving glucans within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044043 ! multi-organism glucan metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052416 name: metabolism by host of symbiont macromolecule namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction is_a: GO:0052419 ! metabolism by host of substance in symbiont [Term] id: GO:0052417 name: metabolism by host of symbiont protein namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052416 ! metabolism by host of symbiont macromolecule is_a: GO:0052418 ! metabolism by organism of protein in other organism involved in symbiotic interaction [Term] id: GO:0052418 name: metabolism by organism of protein in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "metabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0019538 ! protein metabolic process is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052419 name: metabolism by host of substance in symbiont namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052420 name: metabolism by host of symbiont xylan namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052421 ! metabolism by organism of xylan in other organism involved in symbiotic interaction [Term] id: GO:0052421 name: metabolism by organism of xylan in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving xylan within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0045491 ! xylan metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052422 name: modulation by host of symbiont catalytic activity namespace: biological_process def: "The process in which an organism effects a change in symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modulation by host of symbiont enzyme activity" EXACT [GOC:tb] is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052428 ! modification by host of symbiont molecular function [Term] id: GO:0052423 name: positive regulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of defense response in other organism by specific elicitors" EXACT [] synonym: "positive regulation by organism of gene-for-gene resistance in other organism" EXACT [] synonym: "positive regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED [] is_a: GO:0052297 ! modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052424 name: modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system namespace: biological_process def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type III secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052425 name: modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system namespace: biological_process def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type II secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052426 name: modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system namespace: biological_process def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type IV secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052427 name: modulation by host of symbiont protease activity namespace: biological_process def: "The process in which an organism effects a change in symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052198 ! modulation of protease activity in other organism involved in symbiotic interaction is_a: GO:0052422 ! modulation by host of symbiont catalytic activity [Term] id: GO:0052428 name: modification by host of symbiont molecular function namespace: biological_process def: "The process in which an organism effects a change in the function of proteins in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modification by host of symbiont protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0052182 ! modification by host of symbiont morphology or physiology via secreted substance is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052429 name: modulation by organism of symbiont B-cell mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "regulation by organism of symbiont B-cell mediated immune response" EXACT [] is_obsolete: true [Term] id: GO:0052430 name: modulation by host of symbiont RNA levels namespace: biological_process def: "The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052249 ! modulation of RNA levels in other organism involved in symbiotic interaction [Term] id: GO:0052431 name: modulation by organism of symbiont T-cell mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a symbiont organism, where the two organisms are in a symbiotic interaction. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052432 name: modulation by organism of symbiont apoptosis namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052433 name: modulation by organism of apoptosis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] is_a: GO:0042981 ! regulation of apoptosis is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052434 name: modulation by organism of symbiont cell-mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont cell-based immune response" EXACT [] is_obsolete: true [Term] id: GO:0052435 name: modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of defense-related symbiont MAPK-mediated signal transduction pathway by organism" EXACT [] synonym: "modulation of defense-related symbiont mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT [] is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction [Term] id: GO:0052436 name: modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the symbiont calcium-dependent protein kinase signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont CDPK pathway" EXACT [] is_obsolete: true [Term] id: GO:0052437 name: modulation by organism of defense-related symbiont calcium ion flux namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont Ca2+ flux" EXACT [] is_obsolete: true [Term] id: GO:0052438 name: modulation by organism of defense-related symbiont callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052439 name: modulation by organism of defense-related symbiont cell wall callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052440 name: modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052441 name: modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052250 ! modulation of signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052442 name: modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation of defense-related symbiont JA-mediated signal transduction pathway by organism" EXACT [] is_obsolete: true [Term] id: GO:0052443 name: modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation of defense-related JA-mediated signal transduction pathway in other organism" EXACT [] is_a: GO:0052250 ! modulation of signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052444 name: modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation of defense-related symbiont SA-mediated signal transduction pathway by organism" EXACT [] is_obsolete: true [Term] id: GO:0052445 name: modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation of defense-related SA-mediated signal transduction pathway in other organism" EXACT [] is_a: GO:0052250 ! modulation of signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052446 name: modulation by organism of defense-related symbiont cell wall thickening namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont defensive cell wall thickening" RELATED [] is_obsolete: true [Term] id: GO:0052447 name: modulation by organism of symbiont ethylene-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052448 name: modulation by organism of ethylene levels in symbiont namespace: biological_process def: "OBSOLETE. The alteration by an organism of the levels of ethylene in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052449 name: modulation by organism of ethylene levels in other organism involved in symbiotic interaction namespace: biological_process def: "The alteration by an organism of the levels of ethylene in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of ethylene levels in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction [Term] id: GO:0052450 name: modulation by organism of induced systemic resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052451 name: modulation by organism of symbiont inflammatory response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052452 name: modulation by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation of symbiont innate immune response" EXACT [] is_obsolete: true [Term] id: GO:0052453 name: modulation by organism of symbiont intracellular transport namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation of symbiont intracellular trafficking" EXACT [] is_obsolete: true [Term] id: GO:0052454 name: modulation by organism of symbiont jasmonic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont JA-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052455 name: modulation by organism of jasmonic acid levels in symbiont namespace: biological_process def: "OBSOLETE. The alteration by an organism of the levels of jasmonic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052456 name: modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction namespace: biological_process def: "The alteration by an organism of the levels of jasmonic acid in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of jasmonic acid levels in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction [Term] id: GO:0052457 name: modulation by organism of defense-related symbiont nitric oxide production namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont NO production" EXACT [] is_obsolete: true [Term] id: GO:0052458 name: modulation by organism of symbiont non-apoptotic programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052460 name: modulation by host of nutrient release from symbiont namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052313 ! modulation of nutrient release from other organism involved in symbiotic interaction relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont [Term] id: GO:0052461 name: modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052462 name: modulation by host of symbiont phagocytosis namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052231 ! modulation of phagocytosis in other organism involved in symbiotic interaction [Term] id: GO:0052463 name: modulation by organism of symbiont phytoalexin production namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052464 name: modulation by organism of symbiont programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation of symbiont HR" BROAD [] synonym: "modulation of symbiont hypersensitive response" NARROW [] synonym: "modulation of symbiont PCD" EXACT [] is_obsolete: true [Term] id: GO:0052465 name: modulation by organism of defense-related symbiont reactive oxygen species production namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont active oxygen species production" EXACT [] synonym: "modulation by organism of defense-related symbiont AOS production" EXACT [] synonym: "modulation by organism of defense-related symbiont metabolic burst" EXACT [] synonym: "modulation by organism of defense-related symbiont oxidative burst" EXACT [] synonym: "modulation by organism of defense-related symbiont reactive oxidative species production" EXACT [] synonym: "modulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] synonym: "modulation by organism of defense-related symbiont respiratory burst" EXACT [] synonym: "modulation by organism of defense-related symbiont ROI production" EXACT [] synonym: "modulation by organism of defense-related symbiont ROS production" EXACT [] is_obsolete: true [Term] id: GO:0052466 name: modulation by organism of symbiont resistance gene-dependent defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense response in symbiont by specific elicitors" EXACT [] synonym: "modulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] synonym: "modulation by organism of symbiont gene-for-gene resistance" EXACT [] is_obsolete: true [Term] id: GO:0052467 name: modulation by organism of symbiont salicylic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont SA-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052468 name: modulation by organism of salicylic acid levels in symbiont namespace: biological_process def: "OBSOLETE. The alteration by an organism of the levels of salicylic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052469 name: modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction namespace: biological_process def: "The alteration by an organism of the levels of salicylic acid in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of salicylic acid levels in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction [Term] id: GO:0052470 name: modulation by host of symbiont signal transduction pathway namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052250 ! modulation of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052471 name: modulation by organism of systemic acquired resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052472 name: modulation by host of symbiont transcription namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of symbiont transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052312 ! modulation of transcription in other organism involved in symbiotic interaction [Term] id: GO:0052473 name: negative regulation by organism of symbiont B-cell mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052474 name: negative regulation by organism of symbiont T-cell mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052475 name: negative regulation by organism of symbiont cell-mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont cell-based immune response" EXACT [] is_obsolete: true [Term] id: GO:0052476 name: negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. synonym: "negative regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] synonym: "suppression by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052477 name: negative regulation by organism of defense-related symbiont callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of callose deposition performed by the symbiont as part of its defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "suppression by organism of defense-related symbiont callose deposition" EXACT [] is_obsolete: true [Term] id: GO:0052478 name: negative regulation by organism of defense-related symbiont cell wall callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. is_obsolete: true [Term] id: GO:0052479 name: negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "suppression by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052480 name: negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of defense-related symbiont JA-mediated signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052481 name: negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative modulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] synonym: "negative modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052482 name: defense response by cell wall thickening namespace: biological_process def: "A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism." [GOC:mtg_pamgo_17jul06] synonym: "cell wall thickening during defense response" RELATED [GOC:dph] is_a: GO:0006952 ! defense response is_a: GO:0033554 ! cellular response to stress is_a: GO:0052386 ! cell wall thickening [Term] id: GO:0052483 name: negative regulation by organism of entry into cell of other organism via phagocytosis involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops or prevents itself undergoing phagocytosis into a cell in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED [] synonym: "downregulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED [] synonym: "inhibition by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of entry into cell of other organism via other organism phagocytosis during symbiotic interaction" RELATED [] synonym: "negative regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051834 ! evasion or tolerance of defenses of other organism involved in symbiotic interaction is_a: GO:0052373 ! negative regulation by organism of entry into other organism involved in symbiotic interaction is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction [Term] id: GO:0052484 name: negative regulation by organism of symbiont ethylene-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "suppression by organism of symbiont ethylene-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052485 name: negative regulation by organism of symbiont inflammatory response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052486 name: negative regulation by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the symbiont organism, the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation of symbiont innate immune response" EXACT [] is_obsolete: true [Term] id: GO:0052487 name: negative regulation by organism of symbiont jasmonic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "suppression by organism of symbiont JA-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052488 name: negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "suppression of general elicitor induced symbiont innate immunity" EXACT [] synonym: "suppression of general elicitor-induced symbiont innate immunity" EXACT [] synonym: "suppression of MAMP induced symbiont innate immunity" EXACT [] synonym: "suppression of MAMP-induced symbiont innate immunity" EXACT [] synonym: "suppression of PAMP induced symbiont innate immunity" EXACT [] synonym: "suppression of PAMP-induced symbiont innate immunity" EXACT [] synonym: "suppression of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT [] is_obsolete: true [Term] id: GO:0052489 name: negative regulation by host of symbiont programmed cell death namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by host of symbiont programmed cell death" EXACT [] synonym: "down-regulation by host of symbiont programmed cell death" EXACT [] synonym: "downregulation by host of symbiont programmed cell death" EXACT [] synonym: "inhibition by host of symbiont programmed cell death" NARROW [] synonym: "inhibition of symbiont programmed cell death" EXACT [] is_a: GO:0052490 ! negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052490 name: negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "inhibition of programmed cell death in other organism" EXACT [] synonym: "negative regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052491 name: negative regulation by organism of symbiont salicylic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation of symbiont SA-mediated defense response" EXACT [] synonym: "suppression by organism of symbiont salicylic acid-mediated defense response" EXACT [] synonym: "suppression of symbiont SA mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052492 name: negative regulation by host of symbiont signal transduction pathway namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by host of symbiont signal transduction pathway" EXACT [] synonym: "down-regulation by host of symbiont signal transduction pathway" EXACT [] synonym: "downregulation by host of symbiont signal transduction pathway" EXACT [] synonym: "inhibition by host of symbiont signal transduction pathway" NARROW [] synonym: "negative modulation by organism of symbiont signal transduction pathway" EXACT [] is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052493 name: negative regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "negative modulation by organism of other organism signal transduction pathway" RELATED [] synonym: "negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052250 ! modulation of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052494 name: occlusion by host of symbiont vascular system namespace: biological_process def: "The process in which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] subset: gosubset_prok is_a: GO:0052183 ! modification by host of symbiont structure is_a: GO:0052495 ! occlusion by organism of vascular system in other organism involved in symbiotic interaction [Term] id: GO:0052495 name: occlusion by organism of vascular system in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] subset: gosubset_prok synonym: "occlusion by organism of vascular system in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052496 name: occlusion by host of symbiont xylem namespace: biological_process def: "The process in which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052494 ! occlusion by host of symbiont vascular system is_a: GO:0052497 ! occlusion by organism of xylem in other organism involved in symbiotic interaction [Term] id: GO:0052497 name: occlusion by organism of xylem in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "occlusion by organism of xylem in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052495 ! occlusion by organism of vascular system in other organism involved in symbiotic interaction [Term] id: GO:0052498 name: pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "general elicitor-dependent activation of symbiont innate immunity" EXACT [] synonym: "general elicitor-dependent induction of symbiont innate immunity" EXACT [] synonym: "MAMP dependent activation of symbiont innate immunity" EXACT [] synonym: "MAMP dependent induction of symbiont innate immunity" EXACT [] synonym: "PAMP dependent activation of symbiont innate immunity" EXACT [] synonym: "PAMP dependent induction of symbiont innate immunity" EXACT [] synonym: "pathogen-associated molecular pattern dependent activation by organism of symbiont innate immunity" EXACT [] is_obsolete: true [Term] id: GO:0052499 name: pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052500 name: positive regulation by organism of symbiont apoptosis namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of symbiont apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052501 name: positive regulation by organism of apoptosis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of apoptosis in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive regulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "stimulation by organism of apoptosis in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [] is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction is_a: GO:0052433 ! modulation by organism of apoptosis in other organism involved in symbiotic interaction [Term] id: GO:0052502 name: positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT [] synonym: "positive regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] synonym: "stimulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "up regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "up-regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "upregulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] is_a: GO:0052276 ! positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction is_a: GO:0052435 ! modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway is_a: GO:0075100 ! positive regulation by host of symbiont protein kinase-mediated signal transduction [Term] id: GO:0052503 name: positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont calcium-dependent protein kinase pathway during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation of defense-related symbiont CDPK pathway by organism" EXACT [] is_obsolete: true [Term] id: GO:0052504 name: positive regulation by organism of defense-related symbiont callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "induction by organism of defense-related papilla formation in symbiont" NARROW [] synonym: "induction by organism of defense-related symbiont callose deposition" NARROW [] synonym: "positive regulation by organism of defense-related papilla formation in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052505 name: positive regulation by organism of defense-related symbiont cell wall callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "induction by organism of defense-related symbiont cell wall callose deposition" NARROW [] is_obsolete: true [Term] id: GO:0052506 name: positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] is_obsolete: true [Term] id: GO:0052507 name: positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] is_obsolete: true [Term] id: GO:0052508 name: positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] is_obsolete: true [Term] id: GO:0052509 name: positive regulation by symbiont of host defense response namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host defense response" NARROW [] synonym: "stimulation by symbiont of host defense response" NARROW [] synonym: "up regulation by symbiont of host defense response" EXACT [] synonym: "up-regulation by symbiont of host defense response" EXACT [] synonym: "upregulation by symbiont of host defense response" EXACT [] is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052510 name: positive regulation by organism of defense response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense response of other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of defense response of other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense response of other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense response of other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense response of other organism during symbiotic interaction" RELATED [] is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052511 name: positive regulation by organism of symbiont ethylene-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont ethylene-mediated defense response" NARROW [] synonym: "induction by organism of symbiont ethylene-mediated defense response" NARROW [] synonym: "upregulation by organism of symbiont ethylene-mediated defense response" NARROW [] is_obsolete: true [Term] id: GO:0052512 name: positive regulation by organism of hormone or growth regulator levels in symbiont namespace: biological_process def: "OBSOLETE. The increase by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive modulation of hormone or growth regulator levels in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052513 name: positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction namespace: biological_process def: "The increase by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" NARROW [] synonym: "positive modulation of hormone or growth regulator levels in other organism" EXACT [] synonym: "positive regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED [] is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction [Term] id: GO:0052514 name: positive regulation by organism of symbiont inflammatory response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052515 name: positive regulation by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation of symbiont innate immune response" EXACT [] is_obsolete: true [Term] id: GO:0052516 name: positive regulation by organism of symbiont jasmonic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "induction by organism of symbiont JA-mediated defense response" NARROW [] synonym: "induction by organism of symbiont jasmonic acid-mediated defense response" NARROW [] synonym: "positive regulation by organism of symbiont JA-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052517 name: positive regulation by organism of symbiont non-apoptotic programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052519 name: positive regulation by host of nutrient release from symbiont namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by host of nutrient release from symbiont" NARROW [] synonym: "promotion of nutrient release from symbiont" EXACT [] synonym: "stimulation by host of nutrient release from symbiont" NARROW [] synonym: "up regulation by host of nutrient release from symbiont" EXACT [] synonym: "up-regulation by host of nutrient release from symbiont" EXACT [] synonym: "upregulation by host of nutrient release from symbiont" EXACT [] is_a: GO:0052460 ! modulation by host of nutrient release from symbiont is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism involved in symbiotic interaction [Term] id: GO:0052520 name: positive regulation by organism of nutrient release from other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of nutrient release from other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "promotion of nutrient release from other organism" EXACT [] synonym: "stimulation by organism of nutrient release from other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [] is_a: GO:0052313 ! modulation of nutrient release from other organism involved in symbiotic interaction [Term] id: GO:0052521 name: positive regulation by host of symbiont phagocytosis namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by host of symbiont phagocytosis" NARROW [] synonym: "stimulation by host of symbiont phagocytosis" NARROW [] synonym: "up regulation by host of symbiont phagocytosis" EXACT [] synonym: "up-regulation by host of symbiont phagocytosis" EXACT [] synonym: "upregulation by host of symbiont phagocytosis" EXACT [] is_a: GO:0052462 ! modulation by host of symbiont phagocytosis is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction [Term] id: GO:0052522 name: positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of phagocytosis in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of phagocytosis in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [] is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:0052231 ! modulation of phagocytosis in other organism involved in symbiotic interaction [Term] id: GO:0052523 name: positive regulation by organism of symbiont programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "enhancement or induction of symbiont programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052524 name: positive regulation by organism of symbiont salicylic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "induction by organism of symbiont SA-mediated defense response" NARROW [] synonym: "induction by organism of symbiont salicylic acid-mediated defense response" NARROW [] synonym: "positive regulation by organism of symbiont SA-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052525 name: positive regulation by host of symbiont signal transduction pathway namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by host of symbiont signal transduction pathway" NARROW [] synonym: "stimulation by host of symbiont signal transduction pathway" NARROW [] synonym: "up regulation by host of symbiont signal transduction pathway" EXACT [] synonym: "up-regulation by host of symbiont signal transduction pathway" EXACT [] synonym: "upregulation by host of symbiont signal transduction pathway" EXACT [] is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052526 name: positive regulation by organism of signal transduction pathway in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [] is_a: GO:0052250 ! modulation of signal transduction pathway in other organism involved in symbiotic interaction [Term] id: GO:0052527 name: positive regulation by symbiont of host resistance gene-dependent defense response namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host resistance gene-dependent defense response" NARROW [] synonym: "positive regulation by organism of defense response in host by specific elicitors" EXACT [] synonym: "positive regulation by organism of host gene-for-gene resistance" EXACT [] synonym: "positive regulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] synonym: "stimulation by symbiont of host resistance gene-dependent defense response" NARROW [] synonym: "up regulation by symbiont of host resistance gene-dependent defense response" EXACT [] synonym: "up-regulation by symbiont of host resistance gene-dependent defense response" EXACT [] synonym: "upregulation by symbiont of host resistance gene-dependent defense response" EXACT [] is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response is_a: GO:0052423 ! positive regulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction is_a: GO:0052556 ! positive regulation by symbiont of host immune response [Term] id: GO:0052528 name: upregulation by organism of symbiont programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "enhancement of symbiont programmed cell death by organism" EXACT [] is_obsolete: true [Term] id: GO:0052529 name: upregulation by organism of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism increases the frequency, rate or extent of programmed cell death in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "enhancement of other organism programmed cell death by organism" RELATED [] synonym: "upregulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052530 name: positive regulation by organism of symbiont resistance gene-dependent defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense response in symbiont by specific elicitors" EXACT [] synonym: "positive regulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] synonym: "positive regulation by organism of symbiont gene-for-gene resistance" EXACT [] is_obsolete: true [Term] id: GO:0052531 name: positive regulation by organism of defense-related symbiont calcium ion flux namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense-related symbiont Ca2+ flux" EXACT [] is_obsolete: true [Term] id: GO:0052532 name: positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of induced systemic resistance in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of induced systemic resistance in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0052298 ! modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism involved in symbiotic interaction [Term] id: GO:0052533 name: positive regulation by symbiont of host induced systemic resistance namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of induced systemic resistance in host" NARROW [] synonym: "positive regulation by symbiont of induced systemic resistance in host" EXACT [] synonym: "stimulation by symbiont of induced systemic resistance in host" NARROW [] synonym: "up regulation by symbiont of induced systemic resistance in host" EXACT [] synonym: "up-regulation by symbiont of induced systemic resistance in host" EXACT [] synonym: "upregulation by symbiont of induced systemic resistance in host" EXACT [] is_a: GO:0052159 ! modulation by symbiont of host induced systemic resistance is_a: GO:0052509 ! positive regulation by symbiont of host defense response is_a: GO:0052532 ! positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction is_a: GO:0052556 ! positive regulation by symbiont of host immune response [Term] id: GO:0052534 name: positive regulation by organism of induced systemic resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052535 name: positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of systemic acquired resistance in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of systemic acquired resistance in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0052299 ! modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism involved in symbiotic interaction [Term] id: GO:0052536 name: positive regulation by organism of systemic acquired resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052537 name: positive regulation by symbiont of host systemic acquired resistance namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of systemic acquired resistance in host" NARROW [] synonym: "positive regulation by symbiont of systemic acquired resistance in host" EXACT [] synonym: "stimulation by symbiont of systemic acquired resistance in host" NARROW [] synonym: "up regulation by symbiont of systemic acquired resistance in host" EXACT [] synonym: "up-regulation by symbiont of systemic acquired resistance in host" EXACT [] synonym: "upregulation by symbiont of systemic acquired resistance in host" EXACT [] is_a: GO:0052160 ! modulation by symbiont of host systemic acquired resistance is_a: GO:0052509 ! positive regulation by symbiont of host defense response is_a: GO:0052535 ! positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction is_a: GO:0052556 ! positive regulation by symbiont of host immune response [Term] id: GO:0052538 name: positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "positive regulation by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED [] synonym: "stimulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [] is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction [Term] id: GO:0052539 name: positive regulation by symbiont of defense-related host cell wall thickening namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of a host process resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of defense-related host cell wall thickening" NARROW [] synonym: "positive regulation by organism of host defensive cell wall thickening" EXACT [] synonym: "stimulation by symbiont of defense-related host cell wall thickening" NARROW [] synonym: "up regulation by symbiont of defense-related host cell wall thickening" EXACT [] synonym: "up-regulation by symbiont of defense-related host cell wall thickening" EXACT [] synonym: "upregulation by symbiont of defense-related host cell wall thickening" EXACT [] is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening is_a: GO:0052509 ! positive regulation by symbiont of host defense response is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction [Term] id: GO:0052540 name: positive regulation by organism of defense-related symbiont cell wall thickening namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of symbiont defensive cell wall thickening" EXACT [] is_obsolete: true [Term] id: GO:0052541 name: plant-type cell wall cellulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "cell wall cellulose metabolism" EXACT [] synonym: "cellulose and pectin-containing cell wall cellulose metabolic process" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0030243 ! cellulose metabolic process relationship: part_of GO:0009664 ! plant-type cell wall organization [Term] id: GO:0052542 name: defense response by callose deposition namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] synonym: "callose deposition during defense response" RELATED [GOC:dph] synonym: "callose localization during defense response" RELATED [] is_a: GO:0006952 ! defense response is_a: GO:0052545 ! callose localization [Term] id: GO:0052543 name: callose deposition in cell wall namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] synonym: "callose localization in cell wall" EXACT [] synonym: "cell wall callose deposition" EXACT [] synonym: "cell wall callose localization" EXACT [] is_a: GO:0052386 ! cell wall thickening is_a: GO:0052545 ! callose localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0052544 name: defense response by callose deposition in cell wall namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] synonym: "callose deposition in cell wall during defense response" RELATED [GOC:dph] synonym: "callose localization in cell wall during defense response" EXACT [] synonym: "cell wall callose deposition during defense response" EXACT [] synonym: "cell wall callose localization during defense response" EXACT [] is_a: GO:0052482 ! defense response by cell wall thickening is_a: GO:0052542 ! defense response by callose deposition is_a: GO:0052543 ! callose deposition in cell wall [Term] id: GO:0052545 name: callose localization namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06, http://www.onelook.com] synonym: "callose localisation" EXACT [GOC:mah] is_a: GO:0033037 ! polysaccharide localization [Term] id: GO:0052546 name: cell wall pectin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai] synonym: "cell wall pectin metabolism" EXACT [] synonym: "cellulose and pectin-containing cell wall pectin metabolic process" EXACT [] synonym: "pectin metabolism during cell wall biogenesis" EXACT [] synonym: "plant-type cell wall pectin metabolic process" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0045488 ! pectin metabolic process relationship: part_of GO:0009664 ! plant-type cell wall organization [Term] id: GO:0052547 name: regulation of peptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [EC:3.4, GOC:ai] synonym: "peptidase regulator activity" RELATED [] is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0052548 name: regulation of endopeptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:ai, GOC:hjd] synonym: "protease regulator activity" RELATED [] is_a: GO:0052547 ! regulation of peptidase activity [Term] id: GO:0052549 name: response to phytoalexin production by other organism involved in symbiotic interaction namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "response to phytoalexin production by other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction [Term] id: GO:0052550 name: response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "response to defense-related reactive oxygen species production by other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction [Term] id: GO:0052551 name: response to defense-related nitric oxide production by other organism involved in symbiotic interaction namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "response to defense-related nitric oxide production by other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction [Term] id: GO:0052552 name: modulation by organism of immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "modulation by organism of immune response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0050776 ! regulation of immune response is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction [Term] id: GO:0052553 name: modulation by symbiont of host immune response namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction is_a: GO:0052572 ! response to host immune response [Term] id: GO:0052554 name: modulation by organism of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052555 name: positive regulation by organism of immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of immune response of other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of immune response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "stimulation by organism of immune response of other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of immune response of other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of immune response of other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of immune response of other organism during symbiotic interaction" RELATED [] is_a: GO:0050778 ! positive regulation of immune response is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052556 name: positive regulation by symbiont of host immune response namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by symbiont of host immune response" NARROW [] synonym: "stimulation by symbiont of host immune response" NARROW [] synonym: "up regulation by symbiont of host immune response" EXACT [] synonym: "up-regulation by symbiont of host immune response" EXACT [] synonym: "upregulation by symbiont of host immune response" EXACT [] is_a: GO:0052553 ! modulation by symbiont of host immune response is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052557 name: positive regulation by organism of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052558 name: induction by organism of immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "activation by organism of immune response of other organism during symbiotic interaction" EXACT [] synonym: "induction by organism of immune response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052559 name: induction by symbiont of host immune response namespace: biological_process def: "Any process in which an organism activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052556 ! positive regulation by symbiont of host immune response is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052560 name: induction by organism of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052561 name: negative regulation by organism of immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by organism of immune response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of immune response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of immune response of other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of immune response of other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of immune response of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0050777 ! negative regulation of immune response is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052562 name: negative regulation by symbiont of host immune response namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "down regulation by symbiont of host immune response" EXACT [] synonym: "down-regulation by symbiont of host immune response" EXACT [] synonym: "downregulation by symbiont of host immune response" EXACT [] synonym: "inhibition by symbiont of host immune response" NARROW [] is_a: GO:0052553 ! modulation by symbiont of host immune response is_a: GO:0052561 ! negative regulation by organism of immune response of other organism involved in symbiotic interaction [Term] id: GO:0052563 name: negative regulation by organism of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052564 name: response to immune response of other organism involved in symbiotic interaction namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok synonym: "response to immune response of other organism during symbiotic interaction" RELATED [gOC:dph] is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction [Term] id: GO:0052565 name: response to defense-related host nitric oxide production namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism involved in symbiotic interaction is_a: GO:0052572 ! response to host immune response [Term] id: GO:0052566 name: response to host phytoalexin production namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052549 ! response to phytoalexin production by other organism involved in symbiotic interaction is_a: GO:0052572 ! response to host immune response [Term] id: GO:0052567 name: response to defense-related host reactive oxygen species production namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction is_a: GO:0052572 ! response to host immune response [Term] id: GO:0052568 name: response to symbiont phytoalexin production namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052569 name: response to defense-related symbiont nitric oxide production namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052570 name: response to defense-related symbiont reactive oxygen species production namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052571 name: response to symbiont immune response namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. is_obsolete: true [Term] id: GO:0052572 name: response to host immune response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] subset: gosubset_prok is_a: GO:0052200 ! response to host defenses is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction [Term] id: GO:0052573 name: UDP-D-galactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "UDP-D-galactopyranose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-D-galactopyranose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-D-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "uridine diphosphate galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "uridine diphosphate galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0052574 name: UDP-D-galactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "UDP-D-galactopyranose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-D-galactopyranose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-D-galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-galactose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "uridine diphosphate galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "uridine diphosphate galactose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0052573 ! UDP-D-galactose metabolic process [Term] id: GO:0052575 name: carbohydrate localization namespace: biological_process def: "Any process in which a carbohydrate is transported to, or maintained in, a specific location. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [CHEBI:23008, GOC:mah] subset: gosubset_prok synonym: "carbohydrate localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0052576 name: carbohydrate storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [CHEBI:23008, GOC:ai] is_a: GO:0052575 ! carbohydrate localization [Term] id: GO:0052577 name: germacrene-D synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate." [EC:4.2.3.22] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene D-forming] activity" EXACT [EC:4.2.3.22] xref: EC:4.2.3.22 xref: KEGG:R07648 xref: MetaCyc:RXN-8562 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0052578 name: alpha-farnesene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate." [MetaCyc:RXN-8574] synonym: "(E,E)-alpha-farnesene synthase activity" EXACT [MetaCyc:RXN-8574] xref: MetaCyc:RXN-8574 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0052579 name: (+)-pulegone reductase, (+)-isomenthone as substrate, activity namespace: molecular_function def: "Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+." [EC:1.3.1.81, MetaCyc:RXN-5164] synonym: "(+)-isomenthone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.81] xref: EC:1.3.1.81 xref: MetaCyc:RXN-5164 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0052580 name: (+)-pulegone reductase, (-)-menthone as substrate, activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+." [EC:1.3.1.81, MetaCyc:RXN-5163] synonym: "(-)-menthone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.81] xref: EC:1.3.1.81 xref: MetaCyc:RXN-5164 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0052581 name: (-)-isopiperitenone reductase activity namespace: molecular_function def: "Catalysis of the reaction: (6R)-isoperitenone + H(+) + NADPH = (2R,5R)-isopulegone + NADP(+)." [EC:1.3.1.82, RHEA:25651] synonym: "(+)-cis-isopulegone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.82] xref: EC:1.3.1.82 xref: KEGG:R06417 xref: MetaCyc:RXN-5161 xref: RHEA:25651 is_a: GO:0035671 ! enone reductase activity [Term] id: GO:0052582 name: (+)-menthofuran synthase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pulegone + H(+) + NADPH + O(2) = (R)-menthofuran + 2 H(2)O + NADP(+)." [EC:1.14.13.104, RHEA:25661] synonym: "(+)-MFS activity" BROAD [EC:1.14.13.104] synonym: "(+)-pulegone 9-hydroxylase activity" EXACT [EC:1.14.13.104] synonym: "(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating) activity" EXACT [EC:1.14.13.104] synonym: "cytochrome P450 menthofuran synthase activity" EXACT [EC:1.14.13.104] synonym: "menthofuran synthase activity" EXACT [EC:1.14.13.104] xref: EC:1.14.13.104 xref: KEGG:R08923 xref: MetaCyc:1.14.13.104-RXN xref: RHEA:25661 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052583 name: oxidoreductase activity, acting on halogen in donors namespace: molecular_function def: "Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah] xref: EC:1.22 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0052584 name: oxidoreductase activity, acting on halogen in donors, with NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:mah] xref: EC:1.22.1 is_a: GO:0052583 ! oxidoreductase activity, acting on halogen in donors [Term] id: GO:0052585 name: oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:ai] subset: gosubset_prok xref: EC:1.4.5 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0052586 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:jl] xref: EC:1.7.5 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0052587 name: diacetyl reductase ((R)-acetoin forming) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-acetoin + NAD(+) = diacetyl + H(+) + NADH." [EC:1.1.1.303, RHEA:22903] synonym: "(R)-acetoin dehydrogenase activity" EXACT [EC:1.1.1.303] xref: EC:1.1.1.303 xref: KEGG:R02855 xref: MetaCyc:RXN-11036 xref: RHEA:22903 is_a: GO:0019152 ! acetoin dehydrogenase activity [Term] id: GO:0052588 name: diacetyl reductase ((S)-acetoin forming) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-acetoin + NAD(+) = diacetyl + H(+) + NADH." [EC:1.1.1.304, RHEA:27289] synonym: "(S)-acetoin dehydrogenase activity" EXACT [EC:1.1.1.304] xref: EC:1.1.1.304 xref: KEGG:R09078 xref: MetaCyc:RXN-11032 xref: RHEA:27289 is_a: GO:0019152 ! acetoin dehydrogenase activity [Term] id: GO:0052589 name: malate dehydrogenase (menaquinone) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol." [MetaCyc:RXNI-3] synonym: "(S)-malate:(menaquinone) oxidoreductase activity" EXACT [EC:1.1.5.4] synonym: "(S)-malate:menaquinone oxidoreductase activity" EXACT [EC:1.1.5.4] xref: EC:1.1.5.4 xref: MetaCyc:RXNI-3 is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0052590 name: sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol." [MetaCyc:RXN0-5258] comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. subset: gosubset_prok xref: EC:1.1.5.3 xref: MetaCyc:RXN0-5258 is_a: GO:0004368 ! glycerol-3-phosphate dehydrogenase activity [Term] id: GO:0052591 name: sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN] comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. subset: gosubset_prok xref: EC:1.1.5.3 xref: MetaCyc:GLYC3PDEHYDROG-RXN is_a: GO:0052590 ! sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity [Term] id: GO:0052592 name: oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulphur protein as acceptor" EXACT [] xref: EC:1.17.7 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0052593 name: tryptamine:oxygen oxidoreductase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+." [MetaCyc:RXN-1401] xref: EC:1.4.3.21 xref: KEGG:R02173 xref: MetaCyc:RXN-1401 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052594 name: aminoacetone:oxygen oxidoreductase(deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+." [MetaCyc:AMACETOXID-RXN] xref: EC:1.4.3.21 xref: KEGG:R02529 xref: MetaCyc:AMACETOXID-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052595 name: aliphatic-amine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:AMINEOXID-RXN] synonym: "aliphatic-amine:oxygen oxidoreductase(deaminating) activity" EXACT [] xref: EC:1.4.3.21 xref: MetaCyc:AMINEOXID-RXN xref: RHEA:16156 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052596 name: phenethylamine:oxygen oxidoreductase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:AMINEPHEN-RXN] xref: EC:1.4.3.21 xref: KEGG:R02613 xref: MetaCyc:AMINEPHEN-RXN xref: RHEA:25268 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052597 name: diamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide." [MetaCyc:RXN-9599] synonym: "diamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] xref: EC:1.4.3.22 xref: MetaCyc:RXN-9599 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052598 name: histamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-9600] synonym: "1H-Imidazole-4-ethanamine oxidase activity" EXACT [KEGG:R02150] synonym: "1H-Imidazole-4-ethanamine:oxygen oxidoreductase (deaminating) activity" EXACT [KEGG:R02150] synonym: "histamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] xref: EC:1.4.3.22 xref: KEGG:R02150 xref: MetaCyc:RXN-9600 xref: RHEA:25628 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052599 name: methylputrescine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-8244] synonym: "N-methylputrescine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] xref: EC:1.4.3.22 xref: KEGG:R05334 xref: MetaCyc:RXN-8244 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052600 name: propane-1,3-diamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-6381] synonym: "1,3-diaminopropane oxidase activity" EXACT [KEGG:C00986] synonym: "propane-1,3-diamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] synonym: "trimethylenediamine oxidase activity" EXACT [CHEBI:15725] xref: EC:1.4.3.22 xref: KEGG:R03139 xref: MetaCyc:RXN-6381 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052601 name: (S)-limonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-(4S)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4S)-limonene-1,2-epoxide." [MetaCyc:RXN-9409] synonym: "(-)-limonene 1,2-monooxygenase activity" EXACT [EC:1.14.13.107] synonym: "(-)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.107] synonym: "(S)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] xref: EC:1.14.13.107 xref: MetaCyc:RXN-9409 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0052602 name: 4-chloronitrobenzene nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O." [MetaCyc:RXN-8833] xref: MetaCyc:RXN-8833 xref: UM-BBD_enzymeID:e0245 is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0052603 name: 1-chloro-4-nitrosobenzene nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O." [MetaCyc:RXN-8834] xref: MetaCyc:RXN-8834 xref: UM-BBD_enzymeID:e0245 is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0052604 name: delta-tocopherol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol." [MetaCyc:RXN-2561, PMID:12213958] xref: KEGG:R07503 xref: MetaCyc:RXN-2561 is_a: GO:0009975 ! cyclase activity [Term] id: GO:0052605 name: gamma-tocopherol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol." [MetaCyc:RXN-2543, PMID:12213958] xref: KEGG:R07502 xref: MetaCyc:RXN-2543 is_a: GO:0009975 ! cyclase activity [Term] id: GO:0052606 name: chlorophyllide a oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O." [EC:1.13.12.14, MetaCyc:RXN-7676] synonym: "CAO activity" BROAD [EC:1.13.12.14] synonym: "chlorophyll a oxygenase activity" EXACT [] synonym: "chlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14] xref: EC:1.13.12.14 xref: KEGG:R08203 xref: MetaCyc:RXN-7676 xref: RHEA:22679 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0052607 name: 7-hydroxy-chlorophyllide a oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O." [EC:1.13.12.14, MetaCyc:RXN-7677] synonym: "7-hydroxychlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14] synonym: "7-hydroxychlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14] synonym: "CAO activity" BROAD [EC:1.13.12.14] synonym: "chlorophyll b synthetase activity" EXACT [] synonym: "chlorophyll-b synthase activity" EXACT [EC:1.13.12.14] xref: EC:1.13.12.14 xref: KEGG:R08204 xref: MetaCyc:RXN-7677 xref: RHEA:22139 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0052608 name: echinenone 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8214] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99.- xref: MetaCyc:RXN-8214 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052609 name: 4-ketotorulene 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8218] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99.- xref: MetaCyc:RXN-8218 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052610 name: beta-cryptoxanthin hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8026] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99.- xref: MetaCyc:RXN-8026 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052611 name: beta-carotene 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8025] synonym: "beta-carotene 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99.- xref: MetaCyc:RXN-8025 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052612 name: adonirubin 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8187] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99.- xref: MetaCyc:RXN-8187 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052613 name: canthaxanthin 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8186] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99.- xref: MetaCyc:RXN-8186 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052614 name: uracil oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate." [MetaCyc:RXN0-6444, PMID:20369853, PMID:20400551] synonym: "pyrimidine oxygenase activity" BROAD [MetaCyc:RXN0-6444] xref: MetaCyc:RXN0-6444 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0052615 name: ent-kaurene oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol." [MetaCyc:1.14.13.78-RXN] xref: EC:1.14.13.78 xref: MetaCyc:1.14.13.78-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052616 name: ent-kaur-16-en-19-ol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al." [MetaCyc:RXN-5242] xref: EC:1.14.13.78 xref: MetaCyc:RXN-5242 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052617 name: ent-kaur-16-en-19-al oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate." [MetaCyc:RXN-7580] xref: EC:1.14.13.78 xref: MetaCyc:RXN-7580 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052618 name: coenzyme F420-0:L-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate." [MetaCyc:RXN-8080] xref: EC:6.3.2.31 xref: MetaCyc:RXN-8080 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052619 name: coenzyme F420-1:gamma-L-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate." [MetaCyc:RXN-8081] xref: EC:6.3.2.34 xref: MetaCyc:RXN-8081 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052620 name: thymine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2." [MetaCyc:RXN-8646] xref: EC:1.17.99.4 xref: MetaCyc:RXN-8646 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0052621 name: diguanylate cyclase activity namespace: molecular_function alt_id: GO:0043789 def: "Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+)." [EC:2.7.7.65, RHEA:24901] synonym: "GTP:GTP guanylyltransferase activity" BROAD [EC:2.7.7.65] xref: EC:2.7.7.65 xref: KEGG:R08057 xref: MetaCyc:RXN0-5359 xref: RHEA:24901 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0052622 name: ATP dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate." [EC:2.5.1.27, MetaCyc:RXN-4303] synonym: "2-isopentenyl-diphosphate:ATP 2-isopentenyltransferase activity" EXACT [] synonym: "2-isopentenyl-diphosphate:ATP delta2-isopentenyltransferase activity" EXACT [KEGG:R08052] synonym: "ATP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "ATP isopentenyltransferase activity" EXACT [] synonym: "dimethylallyl-diphosphate:ATP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] xref: EC:2.5.1.- xref: KEGG:R08052 xref: MetaCyc:RXN-4303 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0052623 name: ADP dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate." [EC:2.5.1.27, MetaCyc:RXN-4305] synonym: "2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity" EXACT [] synonym: "2-isopentenyl-diphosphate:ADP delta2-isopentenyltransferase activity" EXACT [KEGG:R08051] synonym: "ADP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "ADP isopentenyltransferase activity" EXACT [] synonym: "dimethylallyl-diphosphate:ADP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] xref: EC:2.5.1.- xref: KEGG:R08051 xref: MetaCyc:RXN-4305 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0052624 name: 2-phytyl-1,4-naphthoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+." [MetaCyc:RXN-6723, MetaCyc:RXN-7569, PMID:14617060] synonym: "demethylphylloquinone methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinone methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:demethylphylloquinone methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:salicylate carboxyl methyltransferase activity" EXACT [] synonym: "SA methyltransferase activity" BROAD [] synonym: "salicylate methyltransferase activity" BROAD [] synonym: "salicylic acid methyltransferase activity" BROAD [] xref: EC:2.1.1.- xref: KEGG:R06859 xref: MetaCyc:RXN-6723 xref: MetaCyc:RXN-7569 is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0052625 name: 4-aminobenzoate amino acid synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10884, PMID:19189963] synonym: "4-aminobenzoyl amino acid synthetase activity" EXACT [] synonym: "p-aminobenzoate amino acid synthetase activity" EXACT [] synonym: "p-aminobenzoyl amino acid synthetase activity" EXACT [] synonym: "pABA amino acid synthetase activity" EXACT [] xref: EC:6.3.-.- is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052626 name: benzoate amino acid synthetase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10886, PMID:19189963] synonym: "benzoyl amino acid synthetase activity" EXACT [] xref: EC:6.3.-.- is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052627 name: vanillate amino acid synthetase activity namespace: molecular_function def: "Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10885, PMID:19189963] xref: EC:6.3.-.- is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052628 name: 4-hydroxybenzoate amino acid synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10884, PMID:19189963] synonym: "4-hydroxybenzoyl amino acid synthetase activity" EXACT [] synonym: "4HBA amino acid synthetase activity" EXACT [] synonym: "p-hydroxybenzoate amino acid synthetase activity" EXACT [] synonym: "p-hydroxybenzoyl amino acid synthetase activity" EXACT [] xref: EC:6.3.-.- is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052629 name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [MetaCyc:RXN-10958, PMID:19901554] xref: EC:3.1.3.- xref: MetaCyc:RXN-10958 is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity [Term] id: GO:0052630 name: UDP-N-acetylgalactosamine diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine." [EC:2.7.7.23] subset: gosubset_prok synonym: "N-acetylgalactosamine 1-phosphate uridylyltransferase" EXACT [] synonym: "N-acetylgalactosamine-1-phosphate uridyltransferase activity" EXACT [] synonym: "UDP-acetylgalactosamine pyrophosphorylase activity" EXACT [] synonym: "UDP-GalNAc pyrophosphorylase activity" EXACT [] synonym: "UDP-N-acetylgalactosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphate-N-acetylgalactosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphoacetylgalactosamine phosphorylase activity" EXACT [] synonym: "uridine diphosphoacetylgalactosamine pyrophosphorylase activity" EXACT [] synonym: "UTP:2-acetamido-2-deoxy-alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [] synonym: "UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase activity" EXACT [] xref: EC:2.7.7.- is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0052631 name: sphingolipid delta-8 desaturase activity namespace: molecular_function def: "Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8)." [PMID:17600137, PMID:9786850] xref: MetaCyc:RXN-7798 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0052632 name: citrate hydro-lyase (cis-aconitate-forming) activity namespace: molecular_function def: "Catalysis of the reactions: citrate = cis-aconitate + H2O." [EC:4.2.1.3, MetaCyc:ACONITATEDEHYDR-RXN] synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3] synonym: "cis-aconitase activity" BROAD [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" BROAD [EC:4.2.1.3] xref: EC:4.2.1.3 xref: KEGG:R01325 xref: MetaCyc:ACONITATEDEHYDR-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0052633 name: isocitrate hydro-lyase (cis-aconitate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: cis-aconitate + H2O = isocitrate." [EC:4.2.1.3, MetaCyc:ACONITATEHYDR-RXN] synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3] synonym: "cis-aconitase activity" BROAD [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" BROAD [EC:4.2.1.3] xref: EC:4.2.1.3 xref: KEGG:R01900 xref: MetaCyc:ACONITATEHYDR-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0052634 name: C-19 gibberellin 2-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons." [EC:1.14.11.13, GOC:kad] synonym: "(C-19 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT [] synonym: "C(19) gibberellin 2-oxidase activity" EXACT [] synonym: "C-19 GA 2-oxidase activity" EXACT [] synonym: "C-19 gibberellin 2-beta-hydroxylase activity" EXACT [] synonym: "C-19 gibberellin 2-oxidase activity" EXACT [] synonym: "C-19 gibberellin 2beta-dioxygenase activity" EXACT [] synonym: "C-19 gibberellin 2beta-hydroxylase activity" EXACT [] xref: EC:1.14.11.- is_a: GO:0045543 ! gibberellin 2-beta-dioxygenase activity [Term] id: GO:0052635 name: C-20 gibberellin 2-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons." [EC:1.14.11.13, GOC:kad] synonym: "(C-20 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT [] synonym: "C(20) gibberellin 2-oxidase activity" EXACT [] synonym: "C-20 GA 2-oxidase activity" EXACT [] synonym: "C-20 gibberellin 2-beta-hydroxylase activity" EXACT [] synonym: "C-20 gibberellin 2-oxidase activity" EXACT [] synonym: "C-20 gibberellin 2beta-dioxygenase activity" EXACT [] synonym: "C-20 gibberellin 2beta-hydroxylase activity" EXACT [] xref: EC:1.14.11.- is_a: GO:0045543 ! gibberellin 2-beta-dioxygenase activity [Term] id: GO:0052636 name: arabinosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:ai] synonym: "arabinosyl transferase activity" EXACT [] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0052637 name: delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol." [GOC:ai, MetaCyc:RXN-8319, PMID:19682287] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0052638 name: indole-3-butyrate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP." [MetaCyc:RXN-11655] synonym: "IBA-Glc synthetase activity" EXACT [] synonym: "IBA-glucose synthase activity" EXACT [] synonym: "IBAGlu synthase activity" EXACT [] synonym: "indol-3-ylbutyrylglucose synthase activity" EXACT [] synonym: "indole-3-butyric acid glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:(indol-3-yl)butyrate beta-D-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:indol-3-ylbutyrate glucosyl-transferase activity" EXACT [] synonym: "UDP-glucose:indol-3-ylbutyrate glucosyltransferase activity" EXACT [] synonym: "UDPG-indol-3-ylbutyryl glucosyl transferase activity" EXACT [] synonym: "UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity" EXACT [] synonym: "uridine diphosphoglucose-indolebutyrate glucosyltransferase activity" EXACT [] xref: EC:2.4.1.- xref: MetaCyc:RXN-11655 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052639 name: salicylic acid glucosyltransferase (ester-forming) activity namespace: molecular_function def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP." [MetaCyc:RXN-11659] synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11659] synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] synonym: "UDP:glucose:SA glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] synonym: "UDP:glucose:salicylate glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] synonym: "UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] xref: EC:2.4.1.- xref: MetaCyc:RXN-11659 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052640 name: salicylic acid glucosyltransferase (glucoside-forming) activity namespace: molecular_function def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP." [MetaCyc:RXN-11658] synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11658] synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] synonym: "UDP:glucose:SA glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] synonym: "UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] synonym: "UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] xref: EC:2.4.1.- xref: MetaCyc:RXN-11658 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052641 name: benzoic acid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP." [MetaCyc:RXN-11660] synonym: "benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] synonym: "UDP:glucose:BA glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] synonym: "UDP:glucose:benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] synonym: "UDP:glucose:benzoic acid glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] xref: EC:2.4.1.- is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052642 name: lysophosphatidic acid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol." [PMID:20045079, PMID:7966317] synonym: "LPA phosphatase activity" EXACT [] synonym: "lysophosphatidate phosphatase activity" EXACT [] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0052643 name: chlorophyllide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorophyllides, any chlorophyll lacking the terpenoid side chain such as phytyl or farnesyl." [CHEBI:38206] synonym: "chlorophyllide metabolism" EXACT [] is_a: GO:0015994 ! chlorophyll metabolic process [Term] id: GO:0052644 name: chlorophyllide a metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorophyllide a, a chlorophyll lacking the terpenoid side chain, which is the functional parent of chlorophyll a." [CHEBI:16900] synonym: "chlorophyllide a metabolism" EXACT [] is_a: GO:0052643 ! chlorophyllide metabolic process [Term] id: GO:0052645 name: F420-0 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving F420-0 (5-O-{[(1S)-1-carboxyethoxy](hydroxy)phosphoryl}-1-deoxy-1-(8-hydroxy-2,4-dioxo-2H-pyrimido[4,5-b]quinolin-10(4H)-yl)-D-ribitol), the fragment of coenzyme F420 remaining after formal hydrolytic removal of all of the glutamate residues." [CHEBI:59532] synonym: "coenzyme F420-0 metabolic process" EXACT [CHEBI:59532] synonym: "coenzyme F420-0 metabolism" EXACT [CHEBI:59532] synonym: "F420-0 metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0052648 ! ribitol phosphate metabolic process [Term] id: GO:0052646 name: alditol phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [CHEBI:22297, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "alditol phosphate metabolism" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0052647 name: pentitol phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentitol phosphates, any phosphorylated alditol with a chain of five carbon atoms in the molecule." [CHEBI:25898, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pentitol phosphate metabolism" EXACT [] is_a: GO:0052646 ! alditol phosphate metabolic process [Term] id: GO:0052648 name: ribitol phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribitol phosphates, any phosphorylated form of ribitol, the pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [CHEBI:26554, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribitol phosphate metabolism" EXACT [] is_a: GO:0052647 ! pentitol phosphate metabolic process [Term] id: GO:0052649 name: coenzyme gamma-F420-2 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzyme gamma-F420-2 (F420-2; coenzyme F420; N-{N-[O-(7,8-didemethyl-8-hydroxy-5-deazariboflavin phospho)-(S)-lactyl]-gamma-L-glutamyl}-L-glutamate), the amide obtained by formal condensation of the carboxylic acid group of F420-0 with the amino group of L-gamma-glutamyl-L-glutamic acid." [CHEBI:16848] synonym: "coenzyme F420 metabolic process" EXACT [CHEBI:16848] synonym: "coenzyme F420 metabolism" EXACT [CHEBI:16848] synonym: "coenzyme gamma-F420-2 metabolism" EXACT [] synonym: "F420-2 metabolic process" EXACT [CHEBI:16848] synonym: "F420-2 metabolism" EXACT [CHEBI:16848] is_a: GO:0052648 ! ribitol phosphate metabolic process [Term] id: GO:0052650 name: NADP-retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+." [RHEA:25036] synonym: "all-trans retinal reductase activity" BROAD [EC:1.1.1.300] synonym: "all-trans-retinol dehydrogenase activity" BROAD [EC:1.1.1.300] synonym: "NADP(H)-dependent retinol dehydrogenase/reductase activity" EXACT [EC:1.1.1.300] synonym: "retinol dehydrogenase [NADP+] activity" EXACT [EC:1.1.1.300] synonym: "retinol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.300] xref: EC:1.1.1.300 xref: KEGG:R08379 xref: MetaCyc:RXN-10841 xref: RHEA:25036 is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] id: GO:0052651 name: monoacylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "monoacylglycerol breakdown" EXACT [] synonym: "monoacylglycerol catabolism" EXACT [] synonym: "monoacylglycerol degradation" EXACT [] is_a: GO:0046462 ! monoacylglycerol metabolic process is_a: GO:0046464 ! acylglycerol catabolic process [Term] id: GO:0052652 name: cyclic purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine." [CHEBI:36982] synonym: "cyclic purine nucleotide metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0052653 name: 3',5'-cyclic diguanylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3',5'-cyclic diguanylic acid, a cyclic purine dinucleotide in which the base groups are guanine." [CHEBI:593038] synonym: "3',5'-cyclic diguanylic acid metabolism" EXACT [] synonym: "cdiGMP metabolic process" EXACT [] synonym: "cdiGMP metabolism" EXACT [] synonym: "cyclic diguanylate metabolic process" EXACT [] synonym: "cyclic diguanylate metabolism" EXACT [] is_a: GO:0052652 ! cyclic purine nucleotide metabolic process [Term] id: GO:0052654 name: L-leucine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutaratic acid + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN] synonym: "L-leucine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG:R01090 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity [Term] id: GO:0052655 name: L-valine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutaratic acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN] synonym: "L-valine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG:R01214 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity [Term] id: GO:0052656 name: L-isoleucine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN] synonym: "L-isoleucine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG:R02199 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity [Term] id: GO:0052657 name: guanine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] subset: gosubset_prok synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "GPRT" RELATED [EC:2.4.2.8] synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "guanosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "guanosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "guanylate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "guanylic pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8] xref: EC:2.4.2.8 xref: KEGG:R01229 xref: MetaCyc:GUANPRIBOSYLTRAN-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0052658 name: inositol-1,4,5-trisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19800] synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.56] synonym: "5PTase activity" RELATED [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol triphosphate 5-phosphomonoesterase activity" BROAD [] synonym: "inositol trisphosphate phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "Ins(1,4,5)P3 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "InsP(3) 5-phosphatase activity" BROAD [EC:3.1.3.56] synonym: "InsP3 5-phosphatase activity" BROAD [EC:3.1.3.56] synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] xref: EC:3.1.3.56 xref: KEGG:R03394 xref: MetaCyc:3.1.3.56-RXN xref: RHEA:19800 is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] id: GO:0052659 name: inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11395] synonym: "5PTase activity" RELATED [EC:3.1.3.56] synonym: "D-myo-inositol (1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,3,4,5)P(4) 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] xref: EC:3.1.3.56 xref: KEGG:R03430 xref: MetaCyc:RXN-8730 xref: RHEA:11395 is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0052660 name: R-lactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+." [RHEA:23875] subset: gosubset_prok synonym: "(R)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "D-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] xref: KEGG:R03080 xref: MetaCyc:RXN-8641 xref: RHEA:23875 is_a: GO:0008912 ! lactaldehyde reductase activity [Term] id: GO:0052661 name: S-lactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+." [RHEA:15936] subset: gosubset_prok synonym: "(S)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "L-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] xref: KEGG:R02258 xref: MetaCyc:LACTALDREDUCT-RXN xref: RHEA:15936 is_a: GO:0008912 ! lactaldehyde reductase activity [Term] id: GO:0052662 name: zeaxanthin epoxidase activity namespace: molecular_function def: "Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O." [EC:1.14.13.90] synonym: "zea-epoxidase activity" EXACT [EC:1.14.13.90] synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90] xref: EC:1.14.13.90 xref: KEGG:R06946 "zeaxanthin,NADH:oxygen oxidoreductase activity" xref: KEGG:R07199 "zeaxanthin,NADPH:oxygen oxidoreductase activity" xref: MetaCyc:RXN-7978 xref: RHEA:24085 "zeaxanthin,NADPH:oxygen oxidoreductase activity" xref: RHEA:24089 "zeaxanthin,NADH:oxygen oxidoreductase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052663 name: antheraxanthin epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: antheraxanthin + NAD(P)H + H+ + O2 = all-trans-violaxanthin + NAD(P)+ + H2O." [MetaCyc:RXN-7979] synonym: "antheraxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90] xref: EC:1.14.13.90 xref: KEGG:R06947 "antheraxanthin,NADH:oxygen oxidoreductase activity" xref: KEGG:R07200 "antheraxanthin,NADPH:oxygen oxidoreductase activity" xref: MetaCyc:RXN-7979 xref: RHEA:14938 "zeaxanthin,NADPH:oxygen oxidoreductase activity" xref: RHEA:14942 "zeaxanthin,NADH:oxygen oxidoreductase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052664 name: nitroalkane oxidase activity namespace: molecular_function def: "Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2." [EC:1.7.3.1] synonym: "NAO activity" EXACT [EC:1.7.3.1] synonym: "nitroalkane reductase activity" EXACT [EC:1.7.3.1] synonym: "nitroalkane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1] xref: EC:1.7.3.1 xref: KEGG:R00799 xref: MetaCyc:RXN-11045 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0052665 name: tRNA (uracil-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil." [EC:2.1.1.34] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (uracil-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA uracil-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "transfer ribonucleate uracil 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (uracil 2')-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA uracil 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA uracil-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] xref: EC:2.1.1.- xref: MetaCyc:RXN0-5143 is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity [Term] id: GO:0052666 name: tRNA (cytosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine." [EC:2.1.1.34] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (cytosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA cytosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "transfer ribonucleate cytosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (cytosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA cytosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA cytosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] xref: EC:2.1.1.- xref: MetaCyc:RXN0-5143 is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity [Term] id: GO:0052667 name: phosphomethylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)." [KEGG:R06868, MetaCyc:RXN-5642, RHEA:25322] synonym: "N-methylethanolamine phosphate N-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase activity" EXACT systematic_synonym [KEGG:R06868] xref: EC:2.1.1.- xref: KEGG:R06868 xref: MetaCyc:RXN-5642 xref: RHEA:25322 is_a: GO:0008170 ! N-methyltransferase activity [Term] id: GO:0052668 name: farnesol kinase activity namespace: molecular_function def: "Catalysis of the reaction: farnesol + nucleoside triphosphate = farnesyl monophosphate + nucleoside diphosphate." [GOC:kd, MetaCyc:RXN-11625] synonym: "farnesol phosphotransferase activity" EXACT [] synonym: "trans,trans-farnesol kinase activity" NARROW [] xref: EC:2.7.1.- is_a: GO:0052673 ! prenol kinase activity [Term] id: GO:0052669 name: CTP:2-trans,-6-trans-farnesol kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+." [MetaCyc:RXN-11625] synonym: "CTP:2-trans,-6-trans-farnesol phosphotransferase activity" EXACT [] xref: EC:2.7.1.- xref: MetaCyc:RXN-11625 is_a: GO:0052668 ! farnesol kinase activity [Term] id: GO:0052670 name: geraniol kinase activity namespace: molecular_function def: "Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate." [GOC:kd] synonym: "geraniol phosphotransferase activity" EXACT [] xref: EC:2.7.1.- is_a: GO:0052673 ! prenol kinase activity [Term] id: GO:0052671 name: geranylgeraniol kinase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate." [GOC:kd, MetaCyc:RXN-11629] synonym: "geranylgeraniol phosphotransferase activity" EXACT [] xref: EC:2.7.1.- is_a: GO:0052673 ! prenol kinase activity [Term] id: GO:0052672 name: CTP:geranylgeraniol kinase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP." [MetaCyc:RXN-11629] synonym: "CTP:geranylgeraniol phosphotransferase activity" EXACT [] xref: EC:2.7.1.- xref: MetaCyc:RXN-11629 is_a: GO:0052671 ! geranylgeraniol kinase activity [Term] id: GO:0052673 name: prenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity." [GOC:ai, GOC:kd] synonym: "prenol phosphotransferase activity" EXACT [] synonym: "prenyl alcohol kinase activity" EXACT [] synonym: "prenyl alcohol phosphotransferase activity" EXACT [] xref: EC:2.7.1.- is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0052674 name: ent-pimara-9(11),15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate." [RHEA:25547] synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.31] synonym: "PMD synthase activity" BROAD [EC:4.2.3.31] xref: EC:4.2.3.31 xref: MetaCyc:RXN-9299 xref: RHEA:25547 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052675 name: 3-methylbutanol:NADP oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265, KEGG:R05686] synonym: "3-methylbutanal reductase (NADP) activity" EXACT [] synonym: "3-methylbutanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.265] synonym: "3-methylbutyraldehyde reductase (NADP) activity" EXACT [] synonym: "isoamyl alcohol oxidase (NADP) activity" EXACT [] xref: KEGG:R05686 xref: RHEA:18528 is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] id: GO:0052676 name: 3-methylbutanol:NAD oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265, KEGG:R05685] synonym: "3-methylbutanal reductase (NAD) activity" EXACT [] synonym: "3-methylbutanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.265] synonym: "3-methylbutyraldehyde reductase (NAD) activity" EXACT [] synonym: "isoamyl alcohol oxidase (NAD) activity" EXACT [] xref: KEGG:R05685 xref: RHEA:18532 is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0052677 name: D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+." [EC:1.1.1.287] synonym: "ARD1p" RELATED [EC:1.1.1.287] synonym: "D-arabinitol dehydrogenase 1 activity" BROAD [EC:1.1.1.287] synonym: "D-arabinitol:NADP+ dehydrogenase activity" BROAD [EC:1.1.1.287] synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" BROAD [EC:1.1.1.287] xref: EC:1.1.1.- xref: KEGG:R07143 xref: MetaCyc:RXN-7971 xref: RHEA:21279 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0052678 name: levopimaradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate." [RHEA:25551] synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-abieta-8(14),12-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.32] xref: EC:4.2.3.32 xref: KEGG:R06302 xref: MetaCyc:4.2.3.32-RXN xref: RHEA:25551 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052679 name: terpentetriene synthase activity namespace: molecular_function def: "Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene." [RHEA:25620] synonym: "terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) activity" EXACT systematic_synonym [EC:4.2.3.36] xref: EC:4.2.3.36 xref: MetaCyc:RXN-9455 xref: RHEA:25620 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052680 name: epi-isozizaene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate." [RHEA:25995] synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] activity" EXACT systematic_synonym [EC:4.2.3.37, KEGG:R07830] xref: EC:4.2.3.37 xref: KEGG:R07830 xref: MetaCyc:RXN-9349 xref: RHEA:25995 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052681 name: alpha-bisabolene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate." [RHEA:25439] synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.38] synonym: "bisabolene synthase activity" BROAD [KEGG:R08370] xref: EC:4.2.3.38 xref: KEGG:R08370 xref: MetaCyc:RXN-8550 xref: RHEA:25439 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052682 name: epi-cedrol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate." [RHEA:26118] synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) activity" EXACT systematic_synonym [EC:4.2.3.39] synonym: "8-epicedrol synthase activity" EXACT [] synonym: "epicedrol synthase activity" EXACT [] xref: EC:4.2.3.39 xref: KEGG:R09140 xref: MetaCyc:RXN-10004 xref: RHEA:26118 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052683 name: (Z)-gamma-bisabolene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate." [RHEA:26084] synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.40] xref: EC:4.2.3.40 xref: MetaCyc:RXN-10005 xref: RHEA:26084 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052684 name: L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity namespace: molecular_function def: "Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O." [MetaCyc:RXN0-2382] synonym: "L-serine hydro-lyase (adding indole; L-tryptophan-forming) activity" EXACT [GOC:bf] synonym: "tryptophan synthase beta subunit activity" NARROW [] xref: EC:4.2.1.- xref: KEGG:R00674 xref: MetaCyc:RXN0-2382 xref: RHEA:26435 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0052685 name: perillic acid:CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA." [KEGG:R06368] synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731] xref: EC:6.2.1.- xref: KEGG:R06367 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0052686 name: perillic acid:CoA ligase (AMP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA." [KEGG:R06368] synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731] xref: EC:6.2.1.- xref: KEGG:R06368 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0052687 name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG:R06396] synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737] xref: EC:6.2.1.- xref: KEGG:R06396 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0052688 name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG:R06515] synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737] xref: EC:6.2.1.- xref: KEGG:R06515 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0052689 name: carboxylic ester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a carboxylic ester to give an alcohol and a carboxylate." [EC:3.1.1, GOC:curators] xref: EC:3.1.1 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0052690 name: trichloro-p-hydroquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0031, UM-BBD_reactionID:r0315] synonym: "pentaerythritol tetranitrate reductase activity" RELATED [UM-BBD_enzymeID:e0028] synonym: "tetrachlorohydroquinone reductive dehalogenase activity" RELATED [UM-BBD_enzymeID:e0251] synonym: "trichlorohydroquinone reductive dehalogenase activity" EXACT [] synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028] xref: EC:1.6.99.1 xref: EC:1.8.99.- xref: UM-BBD_reactionID:r0031 xref: UM-BBD_reactionID:r0315 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0052691 name: UDP-arabinopyranose mutase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose." [EC:5.4.99.30, RHEA:28353] synonym: "UDP-arabinopyranose pyranomutase activity" EXACT systematic_synonym [EC:5.4.99.30] synonym: "UDP-L-Ara mutase activity" EXACT [EC:5.4.99.30] synonym: "UDP-L-arabinopyranose furanomutase activity" EXACT [EC:5.4.99.30] synonym: "UDP-L-arabinose mutase activity" EXACT [EC:5.4.99.30] synonym: "uridine-diphosphate-L-arabinose mutase activity" EXACT [EC:5.4.99.30] xref: EC:5.4.99.30 xref: MetaCyc:RXN-11552 xref: RHEA:28353 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0052692 name: raffinose alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose." [MetaCyc:RXN-11502] synonym: "alkaline alpha-galactosidase activity" BROAD [] synonym: "raffinose galactohydrolase activity" BROAD [] synonym: "raffinose-specific alkaline alpha-galactosidase activity" EXACT [PMID:20739305] xref: EC:3.2.1.22 xref: KEGG:R01103 xref: MetaCyc:RXN-11502 is_a: GO:0004557 ! alpha-galactosidase activity [Term] id: GO:0052693 name: epoxyqueuosine reductase activity namespace: molecular_function def: "Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant." [PMID:21502530] xref: EC:1.-.-.- is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0055001 name: muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] is_a: GO:0048468 ! cell development relationship: part_of GO:0042692 ! muscle cell differentiation [Term] id: GO:0055002 name: striated muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] is_a: GO:0055001 ! muscle cell development relationship: part_of GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0055003 name: cardiac myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] synonym: "cardiac myofibril development" EXACT [] synonym: "cardiac myofibril morphogenesis" EXACT [] synonym: "heart myofibril assembly" RELATED [] is_a: GO:0030239 ! myofibril assembly relationship: part_of GO:0055013 ! cardiac muscle cell development [Term] id: GO:0055004 name: atrial cardiac myofibril development namespace: biological_process def: "The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] synonym: "atrial heart myofibril development" EXACT [] is_a: GO:0055003 ! cardiac myofibril assembly relationship: part_of GO:0055014 ! atrial cardiac muscle cell development [Term] id: GO:0055005 name: ventricular cardiac myofibril development namespace: biological_process def: "The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] synonym: "ventricular heart myofibril development" EXACT [] is_a: GO:0055003 ! cardiac myofibril assembly relationship: part_of GO:0055015 ! ventricular cardiac muscle cell development [Term] id: GO:0055006 name: cardiac cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol] synonym: "heart cell development" RELATED [] is_a: GO:0048468 ! cell development relationship: part_of GO:0035051 ! cardiac cell differentiation [Term] id: GO:0055007 name: cardiac muscle cell differentiation namespace: biological_process def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiomyocyte differentiation" EXACT [] synonym: "heart muscle cell differentiation" RELATED [] is_a: GO:0035051 ! cardiac cell differentiation is_a: GO:0051146 ! striated muscle cell differentiation relationship: part_of GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055008 name: cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol] synonym: "heart muscle morphogenesis" EXACT [] synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055009 name: atrial cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol] synonym: "atrial heart muscle morphogenesis" EXACT [] synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac atrium muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis relationship: part_of GO:0003209 ! cardiac atrium morphogenesis relationship: part_of GO:0003228 ! atrial cardiac muscle tissue development [Term] id: GO:0055010 name: ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol] synonym: "cardiac ventricle muscle morphogenesis" EXACT [] synonym: "ventricular heart muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis relationship: part_of GO:0003229 ! ventricular cardiac muscle tissue development [Term] id: GO:0055011 name: atrial cardiac muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol, GOC:mtg_heart] synonym: "atrial cardiomyocyte differentiation" EXACT [] synonym: "atrial heart muscle cell differentiation" EXACT [] is_a: GO:0055007 ! cardiac muscle cell differentiation [Term] id: GO:0055012 name: ventricular cardiac muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_heart] synonym: "ventricular cardiomyocyte differentiation" EXACT [] synonym: "ventricular heart muscle cell differentiation" EXACT [] is_a: GO:0055007 ! cardiac muscle cell differentiation [Term] id: GO:0055013 name: cardiac muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle] synonym: "heart muscle cell development" EXACT [] is_a: GO:0055001 ! muscle cell development is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0055007 ! cardiac muscle cell differentiation [Term] id: GO:0055014 name: atrial cardiac muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol] synonym: "atrial cardiomyocyte development" EXACT [] synonym: "atrial heart muscle development" EXACT [] is_a: GO:0055013 ! cardiac muscle cell development relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation [Term] id: GO:0055015 name: ventricular cardiac muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_muscle] synonym: "ventricular cardiomyocyte development" EXACT [] synonym: "ventricular heart muscle cell development" EXACT [] is_a: GO:0055013 ! cardiac muscle cell development relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation [Term] id: GO:0055016 name: hypochord development namespace: biological_process def: "The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta." [GOC:devbiol, GOC:lb] synonym: "subnotochordal rod development" EXACT [] is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0055017 name: cardiac muscle tissue growth namespace: biological_process def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol] synonym: "heart muscle growth" EXACT [] is_a: GO:0040007 ! growth relationship: part_of GO:0048738 ! cardiac muscle tissue development relationship: part_of GO:0060419 ! heart growth [Term] id: GO:0055018 name: regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "regulation of cardiac muscle fibre development" EXACT [] synonym: "regulation of heart muscle fiber development" EXACT [] is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:0055024 ! regulation of cardiac muscle tissue development is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0048739 ! cardiac muscle fiber development [Term] id: GO:0055019 name: negative regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "down regulation of cardiac muscle fiber development" EXACT [] synonym: "down-regulation of cardiac muscle fiber development" EXACT [] synonym: "downregulation of cardiac muscle fiber development" EXACT [] synonym: "inhibition of cardiac muscle fiber development" NARROW [] synonym: "negative regulation of cardiac muscle fibre development" EXACT [] synonym: "negative regulation of heart muscle fiber development" RELATED [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0055018 ! regulation of cardiac muscle fiber development relationship: negatively_regulates GO:0048739 ! cardiac muscle fiber development relationship: part_of GO:0055026 ! negative regulation of cardiac muscle tissue development [Term] id: GO:0055020 name: positive regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "activation of cardiac muscle fiber development" NARROW [] synonym: "positive regulation of cardiac muscle fibre development" EXACT [] synonym: "positive regulation of heart muscle fiber development" EXACT [] synonym: "stimulation of cardiac muscle fiber development" NARROW [] synonym: "up regulation of cardiac muscle fiber development" EXACT [] synonym: "up-regulation of cardiac muscle fiber development" EXACT [] synonym: "upregulation of cardiac muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0055018 ! regulation of cardiac muscle fiber development relationship: part_of GO:0055025 ! positive regulation of cardiac muscle tissue development relationship: positively_regulates GO:0048739 ! cardiac muscle fiber development [Term] id: GO:0055021 name: regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk] is_a: GO:0055024 ! regulation of cardiac muscle tissue development is_a: GO:0060420 ! regulation of heart growth relationship: regulates GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0055022 name: negative regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "down regulation of cardiac muscle growth" EXACT [] synonym: "down-regulation of cardiac muscle growth" EXACT [] synonym: "downregulation of cardiac muscle growth" EXACT [] synonym: "inhibition of cardiac muscle growth" NARROW [] synonym: "negative regulation of heart muscle growth" RELATED [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0061117 ! negative regulation of heart growth relationship: negatively_regulates GO:0055017 ! cardiac muscle tissue growth relationship: part_of GO:0055026 ! negative regulation of cardiac muscle tissue development [Term] id: GO:0055023 name: positive regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "activation of cardiac muscle growth" NARROW [] synonym: "positive regulation of heart muscle growth" EXACT [] synonym: "stimulation of cardiac muscle growth" NARROW [] synonym: "up regulation of cardiac muscle growth" EXACT [] synonym: "up-regulation of cardiac muscle growth" EXACT [] synonym: "upregulation of cardiac muscle growth" EXACT [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0060421 ! positive regulation of heart growth relationship: part_of GO:0055025 ! positive regulation of cardiac muscle tissue development relationship: positively_regulates GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0055024 name: regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "regulation of heart muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development relationship: regulates GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055025 name: positive regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "activation of cardiac muscle development" NARROW [] synonym: "positive regulation of heart muscle development" EXACT [] synonym: "stimulation of cardiac muscle development" NARROW [] synonym: "up regulation of cardiac muscle development" EXACT [] synonym: "up-regulation of cardiac muscle development" EXACT [] synonym: "upregulation of cardiac muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development relationship: positively_regulates GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055026 name: negative regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "down regulation of cardiac muscle development" EXACT [] synonym: "down-regulation of cardiac muscle development" EXACT [] synonym: "downregulation of cardiac muscle development" EXACT [] synonym: "inhibition of cardiac muscle development" NARROW [] synonym: "negative regulation of heart muscle development" EXACT [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development relationship: negatively_regulates GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055028 name: cortical microtubule namespace: cellular_component def: "Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol." [GOC:mtg_sensu] is_a: GO:0005881 ! cytoplasmic microtubule is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton [Term] id: GO:0055029 name: nuclear DNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0055031 name: gamma-tubulin large complex, equatorial microtubule organizing center namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at equatorial microtubule organizing centers." [GOC:mtg_sensu] synonym: "gamma-tubulin large complex, eMTOC" EXACT [] synonym: "gamma-tubulin large complex, equatorial microtubule organizing centre" EXACT [] is_a: GO:0000931 ! gamma-tubulin large complex is_a: GO:0032155 ! cell division site part relationship: part_of GO:0000923 ! equatorial microtubule organizing center [Term] id: GO:0055032 name: gamma-tubulin large complex, spindle pole body namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the spindle pole body." [GOC:mtg_sensu] is_a: GO:0000931 ! gamma-tubulin large complex relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0055033 name: gamma-tubulin large complex, interphase microtubule organizing center namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at interphase microtubule organizing centers." [GOC:mtg_sensu] synonym: "gamma-tubulin large complex, iMTOC" EXACT [] synonym: "gamma-tubulin large complex, interphase microtubule organizing centre" EXACT [] is_a: GO:0000931 ! gamma-tubulin large complex relationship: part_of GO:0031021 ! interphase microtubule organizing center [Term] id: GO:0055034 name: Bolwig's organ development namespace: biological_process def: "The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [GOC:mtg_sensu] is_a: GO:0001654 ! eye development [Term] id: GO:0055035 name: plastid thylakoid membrane namespace: cellular_component def: "The lipid bilayer membrane of any thylakoid within a plastid." [GOC:jid, GOC:rph] is_a: GO:0042651 ! thylakoid membrane is_a: GO:0044435 ! plastid part relationship: part_of GO:0031976 ! plastid thylakoid [Term] id: GO:0055036 name: virion membrane namespace: cellular_component def: "The lipid bilayer surrounding a virion." [GOC:jid, GOC:rph, PMID:213106] is_a: GO:0044423 ! virion part [Term] id: GO:0055037 name: recycling endosome namespace: cellular_component def: "Organelle consisting of networks of 60nm tubules organized around the microtubule organizing centre in some cell types. They transport receptors from late endosomes back to the plasma membrane for recycling and are also involved in membrane trafficking." [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] synonym: "endosome recycling compartment" RELATED [GOC:dph, PMID:12370264] synonym: "ERC" RELATED [GOC:dph, PMID:1237064] is_a: GO:0005768 ! endosome [Term] id: GO:0055038 name: recycling endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a recycling endosome." [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0055037 ! recycling endosome [Term] id: GO:0055039 name: trichocyst namespace: cellular_component def: "A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in \"nets\" to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft." [GOC:jid, GOC:rph, http://www.iscid.org/encyclopedia/, PMID:3667715] xref: Wikipedia:Trichocyst is_a: GO:0043264 ! extracellular non-membrane-bounded organelle [Term] id: GO:0055040 name: periplasmic flagellum namespace: cellular_component def: "Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella." [GOC:jid, GOC:rph, PMID:15175283, PMID:1624463] is_a: GO:0009288 ! bacterial-type flagellum relationship: part_of GO:0042597 ! periplasmic space [Term] id: GO:0055041 name: cyclopentanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH." [EC:1.1.1.163, RHEA:11731] synonym: "cyclopentanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.163] synonym: "cyclopentanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.163] xref: EC:1.1.1.163 xref: KEGG:R02553 xref: MetaCyc:CYCLOPENTANOL-DEHYDROGENASE-RXN xref: RHEA:11731 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0055042 name: 5-valerolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate." [GOC:jid, GOC:mlg] is_a: GO:0046573 ! lactonohydrolase activity [Term] id: GO:0055043 name: 5-oxovalerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+." [GOC:jid, GOC:mlg] is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0055044 name: symplast namespace: cellular_component def: "The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata." [GOC:mtg_sensu] subset: goslim_pir xref: Wikipedia:Symplast is_a: GO:0005575 ! cellular_component [Term] id: GO:0055045 name: antipodal cell degeneration namespace: biological_process def: "The process in which the antipodal cells undergo programmed cell death." [GOC:mtg_plant] is_a: GO:0010623 ! developmental programmed cell death relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0055046 name: microgametogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure." [GOC:mtg_plant] synonym: "pollen development from the microspore" EXACT systematic_synonym [] xref: Wikipedia:Microgametogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0055047 name: generative cell mitosis namespace: biological_process def: "The process in which the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells." [GOC:mtg_plant] is_a: GO:0007067 ! mitosis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0048232 ! male gamete generation [Term] id: GO:0055048 name: anastral spindle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins." [GOC:expert_rg, GOC:mtg_sensu, GOC:tb, PMID:15034926] is_a: GO:0051225 ! spindle assembly [Term] id: GO:0055049 name: astral spindle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes." [GOC:tb] is_a: GO:0051225 ! spindle assembly [Term] id: GO:0055050 name: astral spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells." [GOC:tb] is_a: GO:0007053 ! spindle assembly involved in male meiosis is_a: GO:0055049 ! astral spindle assembly [Term] id: GO:0055051 name: ATP-binding cassette (ABC) transporter complex, integrated substrate binding namespace: cellular_component def: "A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a \"half transporter\". Two \"half-transporters\" come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex [Term] id: GO:0055052 name: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing namespace: cellular_component def: "A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex [Term] id: GO:0055053 name: mannose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+." [GOC:ct] is_a: GO:0009679 ! hexose:hydrogen symporter activity is_a: GO:0015578 ! mannose transmembrane transporter activity [Term] id: GO:0055054 name: fructose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+." [GOC:ct] is_a: GO:0005353 ! fructose transmembrane transporter activity is_a: GO:0009679 ! hexose:hydrogen symporter activity [Term] id: GO:0055055 name: D-glucose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose." [GOC:ct] is_a: GO:0005356 ! hydrogen:glucose symporter activity is_a: GO:0055056 ! D-glucose transmembrane transporter activity [Term] id: GO:0055056 name: D-glucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:jid, GOC:jsg, GOC:mah] xref: Reactome:260833 "D-glucose transmembrane transporter activity" is_a: GO:0005355 ! glucose transmembrane transporter activity [Term] id: GO:0055057 name: neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167] synonym: "neuroblast cell division" EXACT [] is_a: GO:0048103 ! somatic stem cell division relationship: part_of GO:0007405 ! neuroblast proliferation [Term] id: GO:0055058 name: symmetric neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells." [GOC:dph] is_a: GO:0055057 ! neuroblast division [Term] id: GO:0055059 name: asymmetric neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] is_a: GO:0045165 ! cell fate commitment is_a: GO:0055057 ! neuroblast division [Term] id: GO:0055060 name: asymmetric neuroblast division resulting in ganglion mother cell formation namespace: biological_process def: "Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell." [GOC:dph] is_a: GO:0014017 ! neuroblast fate commitment is_a: GO:0055059 ! asymmetric neuroblast division [Term] id: GO:0055061 name: di-, tri-valent inorganic anion homeostasis namespace: biological_process def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] comment: This term was made obsolete because it has been split. is_obsolete: true consider: GO:0072505 consider: GO:0072506 [Term] id: GO:0055062 name: phosphate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell." [GOC:jid, GOC:mah] is_a: GO:0072506 ! trivalent inorganic anion homeostasis [Term] id: GO:0055063 name: sulfate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell." [GOC:jid, GOC:mah] synonym: "sulphate ion homeostasis" EXACT [] is_a: GO:0072505 ! divalent inorganic anion homeostasis [Term] id: GO:0055064 name: chloride ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell." [GOC:jid, GOC:mah] is_a: GO:0055083 ! monovalent inorganic anion homeostasis [Term] id: GO:0055065 name: metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] subset: gosubset_prok is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0055066 name: di-, tri-valent inorganic cation homeostasis namespace: biological_process def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] comment: This term was made obsolete because it has been split. subset: gosubset_prok is_obsolete: true consider: GO:0072507 consider: GO:0072508 [Term] id: GO:0055067 name: monovalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] subset: gosubset_prok is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0055068 name: cobalt ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cobalt ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] synonym: "cobalt homeostasis" BROAD [] is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0055069 name: zinc ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] synonym: "zinc homeostasis" BROAD [] is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0055070 name: copper ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] subset: gosubset_prok synonym: "copper homeostasis" BROAD [] is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0055071 name: manganese ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell." [GOC:jid, GOC:mah] subset: gosubset_prok synonym: "manganese homeostasis" BROAD [] is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0055072 name: iron ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] subset: gosubset_prok synonym: "iron homeostasis" BROAD [] is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0055073 name: cadmium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cadmium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] synonym: "cadmium homeostasis" EXACT [] is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0055074 name: calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] synonym: "regulation of calcium ion concentration" EXACT [] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0055075 name: potassium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell." [GOC:jid, GOC:mah] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0055076 name: transition metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:jid, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0055077 name: gap junction hemi-channel activity namespace: molecular_function def: "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction." [GOC:dgh] synonym: "connexon channel activity" EXACT [] is_a: GO:0022829 ! wide pore channel activity relationship: part_of GO:0005243 ! gap junction channel activity [Term] id: GO:0055078 name: sodium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0055079 name: aluminum ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of aluminum ions within an organism or cell." [GOC:jid, GOC:lr, GOC:mah] synonym: "aluminium ion homeostasis" EXACT [GOC:mah] is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0055080 name: cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] subset: gosubset_prok is_a: GO:0050801 ! ion homeostasis [Term] id: GO:0055081 name: anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of anions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] is_a: GO:0050801 ! ion homeostasis [Term] id: GO:0055082 name: cellular chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell." [GOC:isa_complete, GOC:jid] subset: gosubset_prok is_a: GO:0019725 ! cellular homeostasis is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0055083 name: monovalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] is_a: GO:0055081 ! anion homeostasis [Term] id: GO:0055084 name: fruiting body development in response to starvation namespace: biological_process def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. The process begins with a response to a lack of nutrients and ends when the fruiting body is a mature structure." [GOC:mtg_sensu] is_a: GO:0030582 ! fruiting body development is_a: GO:0042594 ! response to starvation [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] subset: goslim_generic subset: goslim_pombe xref: Reactome:1252925 "SLC-mediated transmembrane transport" xref: Reactome:1252926 "Transmembrane transport of small molecules" xref: Reactome:1253666 "ABC-family proteins mediated transport" xref: Reactome:1279859 "SLC-mediated transmembrane transport" xref: Reactome:1279860 "Transmembrane transport of small molecules" xref: Reactome:1280597 "ABC-family proteins mediated transport" xref: Reactome:1298773 "SLC-mediated transmembrane transport" xref: Reactome:1298774 "Transmembrane transport of small molecules" xref: Reactome:1299427 "ABC-family proteins mediated transport" xref: Reactome:1326428 "SLC-mediated transmembrane transport" xref: Reactome:1326429 "Transmembrane transport of small molecules" xref: Reactome:1327183 "ABC-family proteins mediated transport" xref: Reactome:1352544 "SLC-mediated transmembrane transport" xref: Reactome:1352545 "Transmembrane transport of small molecules" xref: Reactome:1353278 "ABC-family proteins mediated transport" xref: Reactome:1372771 "SLC-mediated transmembrane transport" xref: Reactome:1372772 "Transmembrane transport of small molecules" xref: Reactome:1373452 "ABC-family proteins mediated transport" xref: Reactome:1392781 "SLC-mediated transmembrane transport" xref: Reactome:1392782 "Transmembrane transport of small molecules" xref: Reactome:1393477 "ABC-family proteins mediated transport" xref: Reactome:1417258 "SLC-mediated transmembrane transport" xref: Reactome:1417259 "Transmembrane transport of small molecules" xref: Reactome:1417977 "ABC-family proteins mediated transport" xref: Reactome:1450347 "SLC-mediated transmembrane transport" xref: Reactome:1450348 "Transmembrane transport of small molecules" xref: Reactome:1451063 "ABC-family proteins mediated transport" xref: Reactome:1470888 "SLC-mediated transmembrane transport" xref: Reactome:1470889 "Transmembrane transport of small molecules" xref: Reactome:1471425 "ABC-family proteins mediated transport" xref: Reactome:1482920 "SLC-mediated transmembrane transport" xref: Reactome:1482921 "Transmembrane transport of small molecules" xref: Reactome:1483376 "ABC-family proteins mediated transport" xref: Reactome:1496716 "SLC-mediated transmembrane transport" xref: Reactome:1496717 "Transmembrane transport of small molecules" xref: Reactome:1497041 "ABC-family proteins mediated transport" xref: Reactome:1514107 "SLC-mediated transmembrane transport" xref: Reactome:1514108 "Transmembrane transport of small molecules" xref: Reactome:1514428 "ABC-family proteins mediated transport" xref: Reactome:1521084 "Transmembrane transport of small molecules" xref: Reactome:1521280 "SLC-mediated transmembrane transport" xref: Reactome:1521291 "ABC-family proteins mediated transport" xref: Reactome:1526677 "SLC-mediated transmembrane transport" xref: Reactome:1526678 "Transmembrane transport of small molecules" xref: Reactome:1526996 "ABC-family proteins mediated transport" xref: Reactome:1532404 "SLC-mediated transmembrane transport" xref: Reactome:1532405 "Transmembrane transport of small molecules" xref: Reactome:1532734 "ABC-family proteins mediated transport" xref: Reactome:1535963 "SLC-mediated transmembrane transport" xref: Reactome:1535964 "Transmembrane transport of small molecules" xref: Reactome:1538017 "SLC-mediated transmembrane transport" xref: Reactome:1538018 "Transmembrane transport of small molecules" xref: Reactome:1539378 "Transmembrane transport of small molecules" xref: Reactome:1539381 "SLC-mediated transmembrane transport" xref: Reactome:1540316 "SLC-mediated transmembrane transport" xref: Reactome:1540317 "Transmembrane transport of small molecules" xref: Reactome:382551 "Transmembrane transport of small molecules" xref: Reactome:382556 "ABC-family proteins mediated transport" xref: Reactome:425407 "SLC-mediated transmembrane transport" is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process [Term] id: GO:0055086 name: nucleobase, nucleoside and nucleotide metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides." [GOC:vw] subset: goslim_pombe subset: gosubset_prok synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] xref: Reactome:1252960 "Metabolism of nucleotides" xref: Reactome:1279890 "Metabolism of nucleotides" xref: Reactome:1298802 "Metabolism of nucleotides" xref: Reactome:1326463 "Metabolism of nucleotides" xref: Reactome:1352578 "Metabolism of nucleotides" xref: Reactome:1372806 "Metabolism of nucleotides" xref: Reactome:1392817 "Metabolism of nucleotides" xref: Reactome:1417290 "Metabolism of nucleotides" xref: Reactome:1450381 "Metabolism of nucleotides" xref: Reactome:1470936 "Metabolism of nucleotides" xref: Reactome:1482948 "Metabolism of nucleotides" xref: Reactome:1496733 "Metabolism of nucleotides" xref: Reactome:1514123 "Metabolism of nucleotides" xref: Reactome:1520950 "Metabolism of nucleotides" xref: Reactome:1526698 "Metabolism of nucleotides" xref: Reactome:1532424 "Metabolism of nucleotides" xref: Reactome:1535979 "Metabolism of nucleotides" xref: Reactome:1537992 "Metabolism of nucleotides" xref: Reactome:1539242 "Metabolism of nucleotides" xref: Reactome:1540298 "Metabolism of nucleotides" xref: Reactome:15869 "Metabolism of nucleotides" is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0055087 name: Ski complex namespace: cellular_component def: "A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p." [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509, PMID:18042677] xref: Wikipedia:Ski_complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0055088 name: lipid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0055089 name: fatty acid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0055090 name: acylglycerol homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell." [GOC:BHF, GOC:rl] synonym: "glyceride homeostasis" EXACT [] is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0055091 name: phospholipid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0055092 name: sterol homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sterol within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0055093 name: response to hyperoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv] synonym: "response to hyperoxic stress" EXACT [] synonym: "response to increased oxygen tension" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0055094 name: response to lipoprotein stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein stimulus." [GOC:BHF, GOC:rl] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0055095 name: lipoprotein particle mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of a lipoprotein particle." [GOC:rl] synonym: "lipoprotein mediated signalling " EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0071402 ! cellular response to lipoprotein particle stimulus [Term] id: GO:0055096 name: low-density lipoprotein particle mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of low-density lipoprotein particle." [GOC:BHF, GOC:rl] synonym: "low-density lipoprotein mediated signalling" EXACT [] is_a: GO:0055095 ! lipoprotein particle mediated signaling relationship: part_of GO:0071404 ! cellular response to low-density lipoprotein particle stimulus [Term] id: GO:0055097 name: high density lipoprotein particle mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of high density lipoprotein particle." [GOC:BHF, GOC:rl] synonym: "high density lipoprotein mediated signalling" EXACT [] is_a: GO:0055095 ! lipoprotein particle mediated signaling relationship: part_of GO:0071403 ! cellular response to high density lipoprotein particle stimulus [Term] id: GO:0055098 name: response to low-density lipoprotein particle stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus." [GOC:BHF, GOC:rl] synonym: "response to low-density lipoprotein particle stimulus" RELATED [GOC:dph] is_a: GO:0055094 ! response to lipoprotein stimulus [Term] id: GO:0055099 name: response to high density lipoprotein particle stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus." [GOC:BHF, GOC:rl] synonym: "response to high density lipoprotein particle stimulus" EXACT [GOC:dph] is_a: GO:0055094 ! response to lipoprotein stimulus [Term] id: GO:0055100 name: adiponectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism." [GOC:BHF, GOC:rl, PMID:15210937] is_a: GO:0005515 ! protein binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0055101 name: glycerophospholipase inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of a glycerophospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai, GOC:BHF, GOC:rl] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'glycerophosphate activity', which also cannot be found in the literature. is_obsolete: true [Term] id: GO:0055102 name: lipase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:rl] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0055103 name: ligase regulator activity namespace: molecular_function def: "Modulates the activity of a ligase." [GOC:BHF, GOC:rl] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0055104 name: ligase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ligase." [GOC:BHF, GOC:rl] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0055105 name: ubiquitin-protein ligase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ubiquitin-protein ligase." [GOC:BHF, GOC:rl] is_a: GO:0055104 ! ligase inhibitor activity is_a: GO:0055106 ! ubiquitin-protein ligase regulator activity [Term] id: GO:0055106 name: ubiquitin-protein ligase regulator activity namespace: molecular_function def: "Modulates the activity of a ubiquitin-protein ligase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] is_a: GO:0055103 ! ligase regulator activity [Term] id: GO:0055107 name: Golgi to secretory granule transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators] is_a: GO:0046907 ! intracellular transport [Term] id: GO:0055108 name: Golgi to transport vesicle transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid] is_a: GO:0046907 ! intracellular transport relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0055109 name: invagination involved in gastrulation with mouth forming second namespace: biological_process def: "The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055110 name: involution involved in gastrulation with mouth forming second namespace: biological_process def: "The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055111 name: ingression involved in gastrulation with mouth forming second namespace: biological_process def: "The migration of individual cells into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055112 name: delamination involved in gastrulation with mouth forming second namespace: biological_process def: "The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0060232 ! delamination relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055113 name: epiboly involved in gastrulation with mouth forming second namespace: biological_process def: "The expansion of one cell sheet over other cells involved in deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055114 name: oxidation-reduction process namespace: biological_process def: "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] subset: gosubset_prok synonym: "oxidation reduction" EXACT [GOC:curators] synonym: "oxidoreductase process" EXACT systematic_synonym [] xref: Wikipedia:Redox is_a: GO:0008152 ! metabolic process [Term] id: GO:0055115 name: entry into diapause namespace: biological_process def: "The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:ds, GOC:jid, GOC:mah] xref: Wikipedia:Diapause is_a: GO:0022611 ! dormancy process [Term] id: GO:0055116 name: entry into reproductive diapause namespace: biological_process def: "The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ds, GOC:jid, GOC:mah] is_a: GO:0055115 ! entry into diapause [Term] id: GO:0055117 name: regulation of cardiac muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0008016 ! regulation of heart contraction relationship: regulates GO:0060048 ! cardiac muscle contraction [Term] id: GO:0055118 name: negative regulation of cardiac muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0045988 ! negative regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction relationship: negatively_regulates GO:0060048 ! cardiac muscle contraction [Term] id: GO:0055119 name: relaxation of cardiac muscle namespace: biological_process def: "The process in which the extent of cardiac muscle contraction is reduced." [GOC:ecd] is_a: GO:0055118 ! negative regulation of cardiac muscle contraction is_a: GO:0090075 ! relaxation of muscle [Term] id: GO:0055120 name: striated muscle dense body namespace: cellular_component def: "A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere." [GOC:kmv, PMID:17492481] is_a: GO:0044449 ! contractile fiber part [Term] id: GO:0055121 name: response to high fluence blue light stimulus by blue high-fluence system namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2." [GOC:mtg_far_red] synonym: "response to high fluence blue light" BROAD [] synonym: "response to high fluence blue light by bhf system" RELATED [] is_a: GO:0009637 ! response to blue light is_a: GO:0009644 ! response to high light intensity [Term] id: GO:0055122 name: response to very low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mtg_far_red] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0055123 name: digestive system development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid] is_a: GO:0048731 ! system development [Term] id: GO:0055124 name: premature neural plate formation namespace: biological_process def: "The formation of the neural plate before the appropriate time." [GOC:jid] is_obsolete: true [Term] id: GO:0055125 name: Nic96 complex namespace: cellular_component def: "A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p." [GOC:jh, PMID:12791264, PMID:15741174] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005643 ! nuclear pore [Term] id: GO:0055126 name: Nup82 complex namespace: cellular_component def: "A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p." [GOC:jh, PMID:12791264, PMID:15741174] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005643 ! nuclear pore [Term] id: GO:0055127 name: vibrational conductance of sound to the inner ear namespace: biological_process def: "The transmission of vibrations via ossicles to the inner ear." [GOC:mh] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0007605 ! sensory perception of sound [Term] id: GO:0055129 name: L-proline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd] synonym: "pyrrolidine-2-carboxylic acid biosynthetic process" BROAD [] is_a: GO:0006561 ! proline biosynthetic process [Term] id: GO:0055130 name: D-alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine." [GOC:ecd] synonym: "(2R)-2-aminopropanoic acid catabolic process" EXACT [] is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0046436 ! D-alanine metabolic process [Term] id: GO:0055131 name: C3HC4-type RING finger domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway." [GOC:amm, InterPro:IPR001841, InterPro:IPR018957] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0060001 name: minus-end directed microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557] synonym: "minus-end directed actin filament motor activity" RELATED [GOC:dph] synonym: "minus-end directed actin-filament motor activity" EXACT [GOC:dph] synonym: "pointed-end directed actin-filament motor activity" EXACT [GOC:dph] is_a: GO:0000146 ! microfilament motor activity [Term] id: GO:0060002 name: plus-end directed microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers." [GOC:dph, PMID:10519557] synonym: "barbed-end directed actin-filament motor activity" EXACT [GOC:dph] synonym: "plus-end directed actin filament motor activity" RELATED [GOC:dph] synonym: "plus-end directed actin-filament motor activity" EXACT [GOC:dph] is_a: GO:0000146 ! microfilament motor activity [Term] id: GO:0060003 name: copper ion export namespace: biological_process def: "The directed movement of copper ions out of a cell or organelle." [GOC:dph] synonym: "copper export" EXACT [GOC:dph] is_a: GO:0035434 ! copper ion transmembrane transport [Term] id: GO:0060004 name: reflex namespace: biological_process def: "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." [GOC:dph, ISBN:087797099] xref: Wikipedia:Reflex is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0060005 name: vestibular reflex namespace: biological_process def: "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [PMID:11784757] is_a: GO:0060004 ! reflex [Term] id: GO:0060006 name: angular vestibuloocular reflex namespace: biological_process def: "A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757] is_a: GO:0060005 ! vestibular reflex [Term] id: GO:0060007 name: linear vestibuloocular reflex namespace: biological_process def: "A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757] is_a: GO:0060005 ! vestibular reflex [Term] id: GO:0060008 name: Sertoli cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0008584 ! male gonad development [Term] id: GO:0060009 name: Sertoli cell development namespace: biological_process def: "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0060008 ! Sertoli cell differentiation [Term] id: GO:0060010 name: Sertoli cell fate commitment namespace: biological_process def: "The process in which the cellular identity of Sertoli cells is acquired and determined." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0045165 ! cell fate commitment is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0060008 ! Sertoli cell differentiation [Term] id: GO:0060011 name: Sertoli cell proliferation namespace: biological_process def: "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] is_a: GO:0008283 ! cell proliferation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0008584 ! male gonad development [Term] id: GO:0060012 name: synaptic transmission, glycinergic namespace: biological_process def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dph] synonym: "glycinergic synaptic transmission" EXACT [] is_a: GO:0007270 ! neuron-neuron synaptic transmission [Term] id: GO:0060013 name: righting reflex namespace: biological_process def: "A reflex process in which an animal immediately tries to turn over after being placed in a supine position." [GOC:dph, PMID:8635460] synonym: "righting response" EXACT [GOC:dph] is_a: GO:0060004 ! reflex [Term] id: GO:0060014 name: granulosa cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals." [GOC:dph] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0060015 name: granulosa cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become granulosa cells." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0060014 ! granulosa cell differentiation [Term] id: GO:0060016 name: granulosa cell development namespace: biological_process def: "The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0060014 ! granulosa cell differentiation [Term] id: GO:0060017 name: parathyroid gland development namespace: biological_process def: "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0060018 name: astrocyte fate commitment namespace: biological_process def: "The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte." [GOC:dph] is_a: GO:0021781 ! glial cell fate commitment relationship: part_of GO:0048708 ! astrocyte differentiation [Term] id: GO:0060019 name: radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0060020 name: Bergmann glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501] is_a: GO:0048708 ! astrocyte differentiation [Term] id: GO:0060021 name: palate development namespace: biological_process def: "The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "palatum development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0060022 name: hard palate development namespace: biological_process def: "The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "palatum durum development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060021 ! palate development [Term] id: GO:0060023 name: soft palate development namespace: biological_process def: "The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "palatum molle development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "velum palatum development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060021 ! palate development [Term] id: GO:0060024 name: rhythmic synaptic transmission namespace: biological_process def: "Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit." [GOC:dph] is_a: GO:0050804 ! regulation of synaptic transmission [Term] id: GO:0060025 name: regulation of synaptic activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb] is_a: GO:0050804 ! regulation of synaptic transmission relationship: part_of GO:0050803 ! regulation of synapse structure and activity [Term] id: GO:0060026 name: convergent extension namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis." [GOC:dgf, GOC:dph, PMID:12062082] xref: Wikipedia:Convergent_extension is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0060027 name: convergent extension involved in gastrulation namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:dph, PMID:12062082] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060026 ! convergent extension relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0060028 name: convergent extension involved in axis elongation namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism." [GOC:dph, PMID:12062082] is_a: GO:0060026 ! convergent extension relationship: part_of GO:0003401 ! axis elongation [Term] id: GO:0060029 name: convergent extension involved in organogenesis namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ." [GOC:dph, PMID:12062082] is_a: GO:0060026 ! convergent extension [Term] id: GO:0060030 name: dorsal convergence namespace: biological_process def: "The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement." [GOC:dgf, GOC:dph, PMID:12062082] is_a: GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0060027 ! convergent extension involved in gastrulation [Term] id: GO:0060031 name: mediolateral intercalation namespace: biological_process def: "The interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dgf, GOC:dph, PMID:12062082] is_a: GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0060027 ! convergent extension involved in gastrulation [Term] id: GO:0060032 name: notochord regression namespace: biological_process def: "The developmental process in which the stucture of the notochord is destroyed in an embryo." [GOC:dph] is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0048570 ! notochord morphogenesis [Term] id: GO:0060033 name: anatomical structure regression namespace: biological_process def: "The developmental process in which an anatomical stucture is destroyed as a part of its normal progression." [GOC:dph] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0060034 name: notochord cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate." [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030903 ! notochord development [Term] id: GO:0060035 name: notochord cell development namespace: biological_process def: "The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0060034 ! notochord cell differentiation [Term] id: GO:0060036 name: notochord cell vacuolation namespace: biological_process def: "The assembly and arrangement of a vacuole within a cell of the notochord." [GOC:cb, GOC:dph, PMID:10964477] is_a: GO:0007033 ! vacuole organization relationship: part_of GO:0060035 ! notochord cell development [Term] id: GO:0060037 name: pharyngeal system development namespace: biological_process def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph] is_a: GO:0048731 ! system development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0060038 name: cardiac muscle cell proliferation namespace: biological_process def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571] synonym: "cardiac myocyte proliferation" EXACT [] synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473] synonym: "heart muscle cell proliferation" EXACT [] is_a: GO:0014855 ! striated muscle cell proliferation relationship: part_of GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0060039 name: pericardium development namespace: biological_process def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0060040 name: retinal bipolar neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0060041 name: retina development in camera-type eye namespace: biological_process alt_id: GO:0002073 def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729] synonym: "retina development in camera-style eye" EXACT [] synonym: "retinal development" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0060042 name: retina morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu] synonym: "retina morphogenesis in camera-style eye" EXACT [] synonym: "retinogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048593 ! camera-type eye morphogenesis relationship: part_of GO:0060041 ! retina development in camera-type eye [Term] id: GO:0060043 name: regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph] synonym: "regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0055021 ! regulation of cardiac muscle tissue growth relationship: regulates GO:0060038 ! cardiac muscle cell proliferation [Term] id: GO:0060044 name: negative regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "negative regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation relationship: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation [Term] id: GO:0060045 name: positive regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "positive regulation of heart muscle cell proliferation" RELATED [] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation relationship: positively_regulates GO:0060038 ! cardiac muscle cell proliferation [Term] id: GO:0060046 name: regulation of acrosome reaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the acrosome reaction." [GOC:dph] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0007340 ! acrosome reaction [Term] id: GO:0060047 name: heart contraction namespace: biological_process def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] synonym: "cardiac contraction" RELATED [] synonym: "heart beating" EXACT [] synonym: "hemolymph circulation" RELATED [] is_a: GO:0003015 ! heart process relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0060048 name: cardiac muscle contraction namespace: biological_process def: "Muscle contraction of cardiac muscle tissue." [GOC:dph] synonym: "heart muscle contraction" EXACT [] is_a: GO:0006941 ! striated muscle contraction relationship: part_of GO:0060047 ! heart contraction [Term] id: GO:0060049 name: regulation of protein glycosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph] synonym: "regulation of protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0006486 ! protein glycosylation [Term] id: GO:0060050 name: positive regulation of protein glycosylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph] synonym: "positive regulation of protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0060049 ! regulation of protein glycosylation relationship: positively_regulates GO:0006486 ! protein glycosylation [Term] id: GO:0060051 name: negative regulation of protein glycosylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph] synonym: "negative regulation of protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0060049 ! regulation of protein glycosylation relationship: negatively_regulates GO:0006486 ! protein glycosylation [Term] id: GO:0060052 name: neurofilament cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph] synonym: "neurofilament cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045104 ! intermediate filament cytoskeleton organization [Term] id: GO:0060053 name: neurofilament cytoskeleton namespace: cellular_component def: "Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons." [GOC:dph] is_a: GO:0045111 ! intermediate filament cytoskeleton [Term] id: GO:0060054 name: positive regulation of epithelial cell proliferation involved in wound healing namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0060055 name: angiogenesis involved in wound healing namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph, PMID:15039218] is_a: GO:0001525 ! angiogenesis relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0060056 name: mammary gland involution namespace: biological_process def: "The tissue remodeling that removes differentiated mammary epithelia during weaning." [GOC:dph, PMID:15282149] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0060443 ! mammary gland morphogenesis [Term] id: GO:0060057 name: apoptosis involved in mammary gland involution namespace: biological_process def: "The form of programmed cell death that triggers the activity of proteolytic caspases, whose actions dismantle the mammary epithelial cells resulting in their death." [GOC:dph] is_a: GO:0060561 ! apoptosis involved in morphogenesis relationship: part_of GO:0060056 ! mammary gland involution [Term] id: GO:0060058 name: positive regulation of apoptosis involved in mammary gland involution namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptosis of mammary epithelial cells during mammary gland involution." [GOC:dph, PMID:15282149] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000026 ! regulation of multicellular organismal development relationship: positively_regulates GO:0060057 ! apoptosis involved in mammary gland involution [Term] id: GO:0060059 name: embryonic retina morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage ." [GOC:dgh, GOC:dph] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0060060 name: post-embryonic retina morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage ." [GOC:dgh, GOC:dph] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0060061 name: Spemann organizer formation namespace: biological_process def: "Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:bf, GOC:dph] synonym: "Spemann's organizer formation" EXACT [] synonym: "Spemann-Mangold organizer formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0031128 ! developmental induction [Term] id: GO:0060062 name: Spemann organizer formation at the dorsal lip of the blastopore namespace: biological_process def: "Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:dph, PMID:9442883] comment: Occurs in amphibia, cephalochordates, cyclostomes and cartilaginous fish. synonym: "Spemann's organizer formation at the dorsal lip of the blastopore" EXACT [] synonym: "Spemann-Mangold organizer formation at the dorsal lip of the blastopore" EXACT [] is_a: GO:0060061 ! Spemann organizer formation [Term] id: GO:0060063 name: Spemann organizer formation at the embryonic shield namespace: biological_process def: "Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan." [GOC:dph, PMID:9442883] comment: Occurs in Teleost fish. synonym: "Spemann's organizer formation at the embryonic shield" EXACT [] synonym: "Spemann-Mangold organizer formation at the embryonic shield" EXACT [] is_a: GO:0060061 ! Spemann organizer formation [Term] id: GO:0060064 name: Spemann organizer formation at the anterior end of the primitive streak namespace: biological_process def: "Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan." [GOC:dph, PMID:9442883] comment: Occurs in reptiles, birds and mammals. synonym: "Spemann organizer formation in amniotes" RELATED [] synonym: "Spemann's organizer formation at the anterior end of the primitive streak" EXACT [] synonym: "Spemann-Mangold organizer formation at the anterior end of the primitive streak" RELATED [] is_a: GO:0060061 ! Spemann organizer formation [Term] id: GO:0060065 name: uterus development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] synonym: "Mullerian tract development" RELATED [] is_a: GO:0048513 ! organ development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0060066 name: oviduct development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:dph, GOC:ebc, http://www.thefreedictionary.com/oviduct] synonym: "fallopian tube development" NARROW [GOC:bf] synonym: "Mullerian tract development" RELATED [] is_a: GO:0035295 ! tube development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0060067 name: cervix development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] synonym: "Mullerian tract development" RELATED [] is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0060068 name: vagina development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0060069 name: Wnt receptor signaling pathway, regulating spindle positioning namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle." [GOC:bf, GOC:dph, PMID:11532397] synonym: "non-canonical Wnt signaling pathway" BROAD [] synonym: "Wnt receptor signalling pathway, regulating spindle positioning" EXACT [] is_a: GO:0035567 ! non-canonical Wnt receptor signaling pathway [Term] id: GO:0060070 name: canonical Wnt receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488] synonym: "canonical Wnt signaling pathway" EXACT [] synonym: "frizzled-1 receptor signaling pathway" NARROW [] synonym: "Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] synonym: "Wnt receptor signaling pathway via beta-catenin" EXACT [] synonym: "Wnt receptor signalling pathway through beta-catenin" EXACT [] is_a: GO:0016055 ! Wnt receptor signaling pathway [Term] id: GO:0060071 name: Wnt receptor signaling pathway, planar cell polarity pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity." [GOC:bf, GOC:dph, PMID:11532397] synonym: "non-canonical Wnt signaling pathway" RELATED [GOC:bf] synonym: "PCP pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [] synonym: "Wnt-JNK signaling pathway" RELATED [GOC:bf] synonym: "Wnt-PCP signaling pathway" RELATED [GOC:rph] is_a: GO:0035567 ! non-canonical Wnt receptor signaling pathway is_a: GO:0090175 ! regulation of establishment of planar polarity [Term] id: GO:0060072 name: large conductance calcium-activated potassium channel activity namespace: molecular_function alt_id: GO:0022895 def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074] synonym: "BK calcium-activated potassium channel activity" EXACT [] synonym: "BK channel activity" RELATED [] synonym: "BK KCa channels" EXACT [] synonym: "large conductance KCa channels" EXACT [] is_a: GO:0015269 ! calcium-activated potassium channel activity [Term] id: GO:0060073 name: micturition namespace: biological_process def: "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph] synonym: "urination" EXACT [] synonym: "urine voiding" EXACT [] xref: Wikipedia:Urination is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion [Term] id: GO:0060074 name: synapse maturation namespace: biological_process def: "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef] synonym: "synaptic maturation" EXACT [] is_a: GO:0021700 ! developmental maturation is_a: GO:0050808 ! synapse organization relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0060075 name: regulation of resting membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized." [GOC:dph, GOC:ef, ISBN:0195088433] synonym: "regulation of resting potential" EXACT [] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0060076 name: excitatory synapse namespace: cellular_component def: "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] xref: Wikipedia:Excitatory_synapse is_a: GO:0045202 ! synapse [Term] id: GO:0060077 name: inhibitory synapse namespace: cellular_component def: "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] xref: Wikipedia:Inhibitory_postsynaptic_potential is_a: GO:0045202 ! synapse [Term] id: GO:0060078 name: regulation of postsynaptic membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of the postsynaptic membrane potential, which is generated by changes in the membrane potential of the post synaptic neuron that receives information at a synapse. The presynaptic neuron releases neurotransmitters into the synaptic cleft which bind to receptors on the postsynaptic neuron. After being bound by the neurotransmitters, these receptors can open or close an ion channel, allowing ions to enter or leave the cell and therefore altering the membrane potential of the postsynaptic neuron." [GOC:dph, GOC:ef] is_a: GO:0042391 ! regulation of membrane potential relationship: part_of GO:0007268 ! synaptic transmission [Term] id: GO:0060079 name: regulation of excitatory postsynaptic membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef] synonym: "regulation of EPSP" RELATED [] is_a: GO:0051899 ! membrane depolarization is_a: GO:0060078 ! regulation of postsynaptic membrane potential [Term] id: GO:0060080 name: regulation of inhibitory postsynaptic membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of the inhibitory postsynaptic potential (IPSP) which is a temporay decrease in postsynaptic potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dph, GOC:ef] synonym: "IPSP" RELATED [] is_a: GO:0060078 ! regulation of postsynaptic membrane potential is_a: GO:0060081 ! membrane hyperpolarization [Term] id: GO:0060081 name: membrane hyperpolarization namespace: biological_process def: "The process in which membrane potential changes in the hyperpolarizing direction from the resting potential, usually from negative to more negative." [GOC:dph] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0060082 name: eye blink reflex namespace: biological_process def: "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." [GOC:dph, PMID:2913208] synonym: "nictitating membrane reflex" EXACT [] is_a: GO:0060004 ! reflex [Term] id: GO:0060083 name: smooth muscle contraction involved in micturition namespace: biological_process def: "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." [GOC:dph, PMID:15827347] synonym: "smooth muscle contraction involved in urination" RELATED [] synonym: "urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:dph] is_a: GO:0014832 ! urinary bladder smooth muscle contraction relationship: part_of GO:0060073 ! micturition [Term] id: GO:0060084 name: synaptic transmission involved in micturition namespace: biological_process def: "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347] synonym: "synaptic transmission involved in urination" RELATED [] is_a: GO:0007274 ! neuromuscular synaptic transmission relationship: part_of GO:0060073 ! micturition [Term] id: GO:0060085 name: smooth muscle relaxation of the bladder outlet namespace: biological_process def: "A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347] synonym: "synaptic transmission involved in urination" EXACT [] is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:0090075 ! relaxation of muscle relationship: part_of GO:0060073 ! micturition [Term] id: GO:0060086 name: circadian temperature homeostasis namespace: biological_process def: "Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours." [GOC:dph, GOC:tb] synonym: "circadian regulation of body temperature" RELATED [] synonym: "circadian thermoregulation" EXACT [GOC:dph, GOC:tb] is_a: GO:0001659 ! temperature homeostasis is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0060087 name: relaxation of vascular smooth muscle namespace: biological_process def: "A process in which the extent of vascular smooth muscle contraction is reduced. Vascular smooth muscle relaxation is mediated via a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity." [GOC:dph, PMID:15867178, PMID:19996365] synonym: "vascular smooth muscle relaxation" EXACT [] is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:0090075 ! relaxation of muscle relationship: part_of GO:0042311 ! vasodilation [Term] id: GO:0060088 name: auditory receptor cell stereocilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells." [GOC:dph, PMID:10978835] synonym: "auditory receptor cell stereocilium organisation" EXACT [GOC:curators] synonym: "auditory receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0060122 ! inner ear receptor stereocilium organization relationship: part_of GO:0002093 ! auditory receptor cell morphogenesis [Term] id: GO:0060089 name: molecular transducer activity namespace: molecular_function def: "The molecular function that accepts an input of one form and creates an output of a different form." [GOC:mtg_MIT_16mar07] subset: goslim_pir subset: gosubset_prok is_a: GO:0003674 ! molecular_function [Term] id: GO:0060090 name: binding, bridging namespace: molecular_function def: "The binding activity of a molecule that brings together two or more molecules, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07] subset: goslim_pir subset: gosubset_prok synonym: "molecular adaptor activity" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0060091 name: kinocilium namespace: cellular_component def: "A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia." [GOC:dph, PMID:15882574] xref: Wikipedia:Kinocilium is_a: GO:0031513 ! nonmotile primary cilium is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part relationship: part_of GO:0032421 ! stereocilium bundle [Term] id: GO:0060092 name: regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] is_a: GO:0050804 ! regulation of synaptic transmission relationship: regulates GO:0060012 ! synaptic transmission, glycinergic [Term] id: GO:0060093 name: negative regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "negative regulation of glycinergic synaptic transmission" EXACT [] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic relationship: negatively_regulates GO:0060012 ! synaptic transmission, glycinergic [Term] id: GO:0060094 name: positive regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "positive regulation of glycinergic synaptic transmission" EXACT [] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic relationship: positively_regulates GO:0060012 ! synaptic transmission, glycinergic [Term] id: GO:0060095 name: zinc potentiation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "zinc potentiation of glycinergic synaptic transmission" EXACT [] is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic [Term] id: GO:0060096 name: serotonin secretion, neurotransmission namespace: biological_process def: "The regulated release of serotonin by a cell or group of cells, in which released serotonin acts as a neurotransmitter." [GOC:dph] is_a: GO:0001820 ! serotonin secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0060097 name: cytoskeletal rearrangement involved in phagocytosis, engulfment namespace: biological_process def: "The assembly and arrangement of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] is_a: GO:0007010 ! cytoskeleton organization relationship: part_of GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060098 name: membrane reorganization involved in phagocytosis, engulfment namespace: biological_process def: "The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] is_a: GO:0007009 ! plasma membrane organization relationship: part_of GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060099 name: regulation of phagocytosis, engulfment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] is_a: GO:0050764 ! regulation of phagocytosis relationship: regulates GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060100 name: positive regulation of phagocytosis, engulfment namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:0060099 ! regulation of phagocytosis, engulfment relationship: positively_regulates GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060101 name: negative regulation of phagocytosis, engulfment namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] is_a: GO:0050765 ! negative regulation of phagocytosis is_a: GO:0060099 ! regulation of phagocytosis, engulfment relationship: negatively_regulates GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060102 name: collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0060103 name: collagen and cuticulin-based cuticle extracellular matrix part namespace: cellular_component def: "Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer." [GOC:dph] is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060104 name: surface coat of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "surface coat of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060105 name: epicuticle of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060106 name: cortical layer of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060107 name: annuli extracellular matrix namespace: cellular_component def: "The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "annulae" RELATED [] synonym: "annular rings" RELATED [] synonym: "annule(s)" RELATED [] synonym: "annulus" RELATED [] is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060108 name: annular furrow extracellular matrix namespace: cellular_component def: "The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline." [GOC:dph, GOC:kmv, ISSN:15518507] is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060109 name: medial layer of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "medial layer struts" RELATED [] is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060110 name: basal layer of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "basal layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060111 name: alae of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "alae of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060112 name: generation of ovulation cycle rhythm namespace: biological_process def: "The process which controls the timing of the type of sexual cycle seen in female mammals." [GOC:dph] synonym: "generation of estrus cycle rhythm" EXACT [] synonym: "generation of menstrual cycle rhythm" RELATED [] synonym: "generation of oestrus cycle rhythm" EXACT [] is_a: GO:0022602 ! ovulation cycle process [Term] id: GO:0060113 name: inner ear receptor cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound." [GOC:dph] synonym: "inner ear hair cell differentiation" EXACT [] is_a: GO:0042490 ! mechanoreceptor differentiation relationship: part_of GO:0048839 ! inner ear development [Term] id: GO:0060114 name: vestibular receptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell." [GOC:dph] synonym: "vestibular hair cell differentiation" EXACT [] is_a: GO:0060113 ! inner ear receptor cell differentiation [Term] id: GO:0060115 name: vestibular receptor cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a vestibular receptor cell." [GOC:dph] synonym: "vestibular hair cell fate commitment" EXACT [] is_a: GO:0060120 ! inner ear receptor cell fate commitment relationship: part_of GO:0060114 ! vestibular receptor cell differentiation [Term] id: GO:0060116 name: vestibular receptor cell morphogenesis namespace: biological_process def: "Any process that alters the size or shape of a vestibular receptor cell." [GOC:dph, GOC:tb] synonym: "vestibular hair cell morphogenesis" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0060118 ! vestibular receptor cell development [Term] id: GO:0060117 name: auditory receptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] synonym: "auditory hair cell development" EXACT [] is_a: GO:0060119 ! inner ear receptor cell development relationship: part_of GO:0042491 ! auditory receptor cell differentiation [Term] id: GO:0060118 name: vestibular receptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] synonym: "vestibular hair cell development" EXACT [] is_a: GO:0060119 ! inner ear receptor cell development relationship: part_of GO:0060114 ! vestibular receptor cell differentiation [Term] id: GO:0060119 name: inner ear receptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] synonym: "inner ear hair cell development" EXACT [] is_a: GO:0048666 ! neuron development relationship: part_of GO:0060113 ! inner ear receptor cell differentiation [Term] id: GO:0060120 name: inner ear receptor cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become an inner ear receptor cell." [GOC:dph] synonym: "inner ear hair cell fate commitment" EXACT [] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0060113 ! inner ear receptor cell differentiation [Term] id: GO:0060121 name: vestibular receptor cell stereocilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells." [GOC:dph] synonym: "vestibular hair cell stereocilium organization" EXACT [] synonym: "vestibular receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0060122 ! inner ear receptor stereocilium organization relationship: part_of GO:0060116 ! vestibular receptor cell morphogenesis [Term] id: GO:0060122 name: inner ear receptor stereocilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells." [GOC:dph] synonym: "inner ear hair cell receptor stereocilium organization" EXACT [] synonym: "inner ear receptor stereocilium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030030 ! cell projection organization relationship: part_of GO:0060119 ! inner ear receptor cell development [Term] id: GO:0060123 name: regulation of growth hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells." [GOC:dph] is_a: GO:0090276 ! regulation of peptide hormone secretion relationship: regulates GO:0030252 ! growth hormone secretion [Term] id: GO:0060124 name: positive regulation of growth hormone secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells." [GOC:dph] is_a: GO:0060123 ! regulation of growth hormone secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion relationship: positively_regulates GO:0030252 ! growth hormone secretion [Term] id: GO:0060125 name: negative regulation of growth hormone secretion namespace: biological_process def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells." [GOC:dph] is_a: GO:0060123 ! regulation of growth hormone secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion relationship: negatively_regulates GO:0030252 ! growth hormone secretion [Term] id: GO:0060126 name: somatotropin secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] synonym: "growth hormone secreting cell differentiation" EXACT [] synonym: "somatotrope differentiation" RELATED [] synonym: "somatotroph differentiation" RELATED [] synonym: "somatotrophin secreting cell differentiation" EXACT [] synonym: "somatotropic cell differentiation" RELATED [] synonym: "somatrophic cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021984 ! adenohypophysis development [Term] id: GO:0060127 name: prolactin secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] synonym: "epsilon-acidophil differentiation" EXACT [] synonym: "lactotrope differentiation" EXACT [] synonym: "lactotroph differentiation" EXACT [] synonym: "lactotropic cell differentiation" EXACT [] synonym: "mammotrope differentiation" EXACT [] synonym: "mammotroph differentiation" EXACT [] synonym: "mammotrophic cell differentiation" EXACT [] synonym: "mammotropic cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021984 ! adenohypophysis development [Term] id: GO:0060128 name: corticotropin hormone secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT [] synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph] synonym: "corticotrope differentiation" EXACT [] synonym: "corticotroph differentiation" EXACT [] synonym: "corticotrophin hormone secreting cell differentiation" RELATED [] synonym: "corticotropin hormone secreting cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021984 ! adenohypophysis development [Term] id: GO:0060129 name: thyroid-stimulating hormone-secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin." [GOC:dph] synonym: "beta-basophil differentiation" EXACT [] synonym: "thyroid stimulating hormone secreting cell differentiation" EXACT [] synonym: "thyrotrope differentiation" EXACT [] synonym: "thyrotroph differentiation" EXACT [] synonym: "TSH-secreting cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021984 ! adenohypophysis development [Term] id: GO:0060130 name: thyroid-stimulating hormone-secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a thyroid-stimulating hormone-secreting cell over time, from its formation to the mature structure. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph] synonym: "beta-basophil development" EXACT [] synonym: "thyroid stimulating hormone secreting cell development" EXACT [] synonym: "thyrotrope development" EXACT [] synonym: "thyrotroph development" EXACT [] synonym: "TSH-secreting cell development" EXACT [] is_a: GO:0048468 ! cell development relationship: part_of GO:0060129 ! thyroid-stimulating hormone-secreting cell differentiation [Term] id: GO:0060131 name: corticotropin hormone secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] synonym: "adrenocorticotrophic hormone secreting cell development" EXACT [] synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph] synonym: "corticotrope development" EXACT [] synonym: "corticotroph development" RELATED [] synonym: "corticotrophin hormone secreting cell development" RELATED [] synonym: "corticotropin hormone secreting cell development" EXACT [] is_a: GO:0048468 ! cell development relationship: part_of GO:0060128 ! corticotropin hormone secreting cell differentiation [Term] id: GO:0060132 name: prolactin secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] synonym: "epsilon-acidophil development" EXACT [] synonym: "lactotrope development" EXACT [] synonym: "lactotroph development" EXACT [] synonym: "lactotropic cell development" EXACT [] synonym: "mammotrope development" EXACT [] synonym: "mammotroph development" EXACT [] synonym: "mammotrophic cell development" EXACT [] synonym: "mammotropic cell development" EXACT [] is_a: GO:0048468 ! cell development relationship: part_of GO:0060127 ! prolactin secreting cell differentiation [Term] id: GO:0060133 name: somatotropin secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] synonym: "growth hormone secreting cell development" EXACT [] synonym: "somatotrope development" RELATED [] synonym: "somatotroph development" RELATED [] synonym: "somatotrophin secreting cell development" EXACT [] synonym: "somatotropic cell development" EXACT [] synonym: "somatrophic cell development" RELATED [] is_a: GO:0048468 ! cell development relationship: part_of GO:0060126 ! somatotropin secreting cell differentiation [Term] id: GO:0060134 name: prepulse inhibition namespace: biological_process def: "The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse." [GOC:dph, PMID:10341260] synonym: "PPI" RELATED [] synonym: "pre-pulse inhibition" EXACT [] xref: Wikipedia:Prepulse_inhibition is_a: GO:0032102 ! negative regulation of response to external stimulus relationship: part_of GO:0001964 ! startle response [Term] id: GO:0060135 name: maternal process involved in female pregnancy namespace: biological_process def: "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007565 ! female pregnancy [Term] id: GO:0060136 name: embryonic process involved in female pregnancy namespace: biological_process def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007565 ! female pregnancy relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0060137 name: maternal process involved in parturition namespace: biological_process def: "A reproductive process occurring in the mother that results in birth." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007567 ! parturition [Term] id: GO:0060138 name: fetal process involved in parturition namespace: biological_process def: "A reproductive process occurring in the embryo that results in birth." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007567 ! parturition relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0060139 name: positive regulation of apoptosis by virus namespace: biological_process def: "Any viral process that activates or increases the frequency, rate or extent of cell death by apoptosis." [GOC:dph] is_a: GO:0019048 ! virus-host interaction is_a: GO:0043065 ! positive regulation of apoptosis relationship: part_of GO:0006926 ! virus-infected cell apoptosis [Term] id: GO:0060140 name: syncytium formation by plasma membrane fusion of virally targeted cells namespace: biological_process def: "The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0000768 ! syncytium formation by plasma membrane fusion is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0006948 ! induction by virus of host cell-cell fusion [Term] id: GO:0060141 name: positive regulation of syncytium formation by virus namespace: biological_process def: "The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion relationship: part_of GO:0006948 ! induction by virus of host cell-cell fusion [Term] id: GO:0060142 name: regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0000768 ! syncytium formation by plasma membrane fusion [Term] id: GO:0060143 name: positive regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion relationship: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion [Term] id: GO:0060144 name: host cellular processes involved in virus induced gene silencing namespace: biological_process def: "The set of cellular processes occurring in the host cell that contribute to the process of posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes." [GOC:dph] is_a: GO:0009987 ! cellular process relationship: part_of GO:0009616 ! virus induced gene silencing [Term] id: GO:0060145 name: viral gene silencing in virus induced gene silencing namespace: biological_process def: "The posttranscriptional gene silencing of viral genes after viral infection." [GOC:dph] is_a: GO:0016441 ! posttranscriptional gene silencing relationship: part_of GO:0009616 ! virus induced gene silencing [Term] id: GO:0060146 name: host gene silencing in virus induced gene silencing namespace: biological_process def: "The posttranscriptional gene silencing of host genes that are homologous to viral genes after viral infection." [GOC:dph] is_a: GO:0016441 ! posttranscriptional gene silencing relationship: part_of GO:0009616 ! virus induced gene silencing [Term] id: GO:0060147 name: regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] is_a: GO:0060968 ! regulation of gene silencing relationship: regulates GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0060148 name: positive regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0060147 ! regulation of posttranscriptional gene silencing relationship: positively_regulates GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0060149 name: negative regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] is_a: GO:0060147 ! regulation of posttranscriptional gene silencing is_a: GO:0060969 ! negative regulation of gene silencing relationship: negatively_regulates GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0060150 name: viral triggering of virus induced gene silencing namespace: biological_process def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression of both viral genes and host homologues to those genes by a posttranscriptional mechanism in a virally infected cell." [GOC:dph] is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing relationship: part_of GO:0009616 ! virus induced gene silencing [Term] id: GO:0060151 name: peroxisome localization namespace: biological_process def: "Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325] synonym: "peroxisome localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0060152 name: microtubule-based peroxisome localization namespace: biological_process def: "The microtubule-based process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325] synonym: "microtubule-based peroxisome localisation" EXACT [GOC:mah] is_a: GO:0007017 ! microtubule-based process is_a: GO:0060151 ! peroxisome localization [Term] id: GO:0060153 name: modulation by virus of host cell cycle namespace: biological_process def: "Any viral process that modulates the rate or extent of progression through the cell cycle." [GOC:dph] synonym: "regulation by virus of host cell cycle" EXACT [] synonym: "regulation of host cell cycle by virus" EXACT [] synonym: "viral process regulating host cell cycle" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0044071 ! modulation by symbiont of host cell cycle [Term] id: GO:0060154 name: cellular process regulating host cell cycle in response to virus namespace: biological_process def: "Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus." [GOC:dph] is_a: GO:0009615 ! response to virus is_a: GO:0051726 ! regulation of cell cycle relationship: part_of GO:0019055 ! modification by virus of host cell cycle regulation [Term] id: GO:0060155 name: platelet dense granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:dph, PMID:11487378] synonym: "bull's eye body organization and biogenesis" RELATED [] synonym: "platelet dense body organization and biogenesis" RELATED [] synonym: "platelet dense granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0060156 name: milk ejection namespace: biological_process def: "An automatic response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." [GOC:dph, GOC:st] is_a: GO:0060004 ! reflex [Term] id: GO:0060157 name: urinary bladder development namespace: biological_process def: "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion." [GOC:dph, GOC:ln] is_a: GO:0048513 ! organ development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0060158 name: activation of phospholipase C activity by dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:tb, PMID:12675914] synonym: "activation of phospholipase C activity by dopamine receptor signalling pathway" EXACT [GOC:mah] synonym: "dopamine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "phospholipase C-activating dopamine receptor signaling pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0060159 name: regulation of dopamine receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway relationship: regulates GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0060160 name: negative regulation of dopamine receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "negative regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway relationship: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0060161 name: positive regulation of dopamine receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "positive regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway relationship: positively_regulates GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0060162 name: negative regulation of phospholipase C-activating dopamine receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway." [GOC:dph, GOC:tb, PMID:15016423] synonym: "negative regulation of dopamine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of phospholipase C-activating dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway relationship: negatively_regulates GO:0060158 ! activation of phospholipase C activity by dopamine receptor signaling pathway [Term] id: GO:0060163 name: subpallium neuron fate commitment namespace: biological_process def: "The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] synonym: "subpallium neuronal precursor fate commitment" RELATED [] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0060164 name: regulation of timing of neuron differentiation namespace: biological_process def: "The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron." [GOC:dph] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0048505 ! regulation of timing of cell differentiation [Term] id: GO:0060165 name: regulation of timing of subpallium neuron differentiation namespace: biological_process def: "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] is_a: GO:0060164 ! regulation of timing of neuron differentiation relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0060166 name: olfactory pit development namespace: biological_process def: "The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx." [GOC:dph, ISBN:0124020607] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043584 ! nose development [Term] id: GO:0060167 name: regulation of adenosine receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "regulation of adenosine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway relationship: regulates GO:0001973 ! adenosine receptor signaling pathway [Term] id: GO:0060168 name: positive regulation of adenosine receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "positive regulation of adenosine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway relationship: positively_regulates GO:0001973 ! adenosine receptor signaling pathway [Term] id: GO:0060169 name: negative regulation of adenosine receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "negative regulation of adenosine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway relationship: negatively_regulates GO:0001973 ! adenosine receptor signaling pathway [Term] id: GO:0060170 name: cilium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cilium." [GOC:dph, GOC:rph] is_a: GO:0031253 ! cell projection membrane is_a: GO:0044441 ! cilium part [Term] id: GO:0060171 name: stereocilium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a stereocilium." [GOC:dph, GOC:rph] is_a: GO:0031528 ! microvillus membrane is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part relationship: part_of GO:0032420 ! stereocilium [Term] id: GO:0060172 name: spindle astral microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph] is_a: GO:0007019 ! microtubule depolymerization is_a: GO:0030953 ! spindle astral microtubule organization [Term] id: GO:0060173 name: limb development namespace: biological_process def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378] synonym: "limb bud development" NARROW [GOC:dph] xref: Wikipedia:Limb_development is_a: GO:0048736 ! appendage development [Term] id: GO:0060174 name: limb bud formation namespace: biological_process def: "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable." [GOC:dgh, GOC:dph] synonym: "limb formation" EXACT [] synonym: "limbbud formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035108 ! limb morphogenesis [Term] id: GO:0060175 name: brain-derived neurotrophic factor receptor activity namespace: molecular_function def: "Combining with brain-derived neurotrophic factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph] synonym: "BDNF receptor activity" RELATED [GOC:dph] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity is_a: GO:0005030 ! neurotrophin receptor activity [Term] id: GO:0060176 name: regulation of aggregation involved in sorocarp development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:dph, GOC:tb] is_a: GO:0031156 ! regulation of sorocarp development relationship: regulates GO:0031152 ! aggregation involved in sorocarp development [Term] id: GO:0060177 name: regulation of angiotensin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin." [GOC:dph, GOC:tb] synonym: "regulation of angiotensin metabolism" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process [Term] id: GO:0060178 name: regulation of exocyst localization namespace: biological_process def: "Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:dph, GOC:tb] synonym: "regulation of exocyst localisation" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0051601 ! exocyst localization [Term] id: GO:0060179 name: male mating behavior namespace: biological_process def: "The specific actions or reactions of a male organism that are associated with reproduction." [GOC:dph, GOC:tb] is_a: GO:0033057 ! multicellular organismal reproductive behavior relationship: part_of GO:0007617 ! mating behavior [Term] id: GO:0060180 name: female mating behavior namespace: biological_process def: "The specific actions or reactions of a female organism that are associated with reproduction." [GOC:dph, GOC:tb] is_a: GO:0033057 ! multicellular organismal reproductive behavior relationship: part_of GO:0007617 ! mating behavior [Term] id: GO:0060182 name: apelin receptor activity namespace: molecular_function def: "Combining with the peptide apelin to initiate a change in cell activity." [GOC:dph] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0060183 name: apelin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an apelin receptor binding to one of its physiological ligands." [GOC:dph] synonym: "apelin receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0060184 name: cell cycle switching namespace: biological_process def: "The process in which a cell switches cell cycle mode." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0060185 name: outer ear unfolding namespace: biological_process def: "The opening and spreading out of the outer ear." [GOC:dph] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0042473 ! outer ear morphogenesis [Term] id: GO:0060186 name: outer ear emergence namespace: biological_process def: "The growth of the outer ear." [GOC:dph] synonym: "ear elevation" RELATED [GOC:dph] synonym: "ear extroversion" RELATED [GOC:dph] synonym: "outer ear growth" RELATED [GOC:dph] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0042473 ! outer ear morphogenesis [Term] id: GO:0060187 name: cell pole namespace: cellular_component def: "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph] is_a: GO:0044464 ! cell part [Term] id: GO:0060188 name: regulation of protein desumoylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0016926 ! protein desumoylation [Term] id: GO:0060189 name: positive regulation of protein desumoylation namespace: biological_process def: "Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0060188 ! regulation of protein desumoylation relationship: positively_regulates GO:0016926 ! protein desumoylation [Term] id: GO:0060190 name: negative regulation of protein desumoylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0060188 ! regulation of protein desumoylation relationship: negatively_regulates GO:0016926 ! protein desumoylation [Term] id: GO:0060191 name: regulation of lipase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0060192 name: negative regulation of lipase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0060191 ! regulation of lipase activity [Term] id: GO:0060193 name: positive regulation of lipase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0060191 ! regulation of lipase activity [Term] id: GO:0060194 name: regulation of antisense RNA transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:jp, GOC:tb, PMID:18075583] is_a: GO:0006355 ! regulation of transcription, DNA-dependent relationship: regulates GO:0009300 ! antisense RNA transcription [Term] id: GO:0060195 name: negative regulation of antisense RNA transcription namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583] is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent is_a: GO:0060194 ! regulation of antisense RNA transcription relationship: negatively_regulates GO:0009300 ! antisense RNA transcription [Term] id: GO:0060196 name: positive regulation of antisense RNA transcription namespace: biological_process def: "Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583] is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent is_a: GO:0060194 ! regulation of antisense RNA transcription relationship: positively_regulates GO:0009300 ! antisense RNA transcription [Term] id: GO:0060197 name: cloacal septation namespace: biological_process def: "The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development." [GOC:dph, GOC:st] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0035844 ! cloaca development [Term] id: GO:0060198 name: clathrin sculpted vesicle namespace: cellular_component def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release." [GOC:dph] is_a: GO:0030136 ! clathrin-coated vesicle [Term] id: GO:0060199 name: clathrin sculpted glutamate transport vesicle namespace: cellular_component def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate." [GOC:dph] is_a: GO:0030133 ! transport vesicle is_a: GO:0060198 ! clathrin sculpted vesicle [Term] id: GO:0060200 name: clathrin sculpted acetylcholine transport vesicle namespace: cellular_component def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine." [GOC:dph] is_a: GO:0030133 ! transport vesicle is_a: GO:0060198 ! clathrin sculpted vesicle [Term] id: GO:0060201 name: clathrin sculpted acetylcholine transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin sculpted acetylcholine transport vesicle." [GOC:dph] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030665 ! clathrin coated vesicle membrane relationship: part_of GO:0060200 ! clathrin sculpted acetylcholine transport vesicle [Term] id: GO:0060202 name: clathrin sculpted acetylcholine transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin sculpted acetylcholine transport vesicle." [GOC:dph] is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0060200 ! clathrin sculpted acetylcholine transport vesicle [Term] id: GO:0060203 name: clathrin sculpted glutamate transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin sculpted glutamate transport vesicle." [GOC:dph] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030665 ! clathrin coated vesicle membrane relationship: part_of GO:0060199 ! clathrin sculpted glutamate transport vesicle [Term] id: GO:0060204 name: clathrin sculpted glutamate transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin sculpted glutamate transport vesicle." [GOC:dph] is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0060199 ! clathrin sculpted glutamate transport vesicle [Term] id: GO:0060205 name: cytoplasmic membrane-bounded vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle." [GOC:dph] synonym: "cytoplasmic membrane-enclosed vesicle lumen" EXACT [] is_a: GO:0031983 ! vesicle lumen is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0060206 name: estrous cycle phase namespace: biological_process def: "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." [GOC:dph] xref: Wikipedia:Estrous_cycle is_a: GO:0022602 ! ovulation cycle process [Term] id: GO:0060207 name: diestrus namespace: biological_process def: "The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0060206 ! estrous cycle phase [Term] id: GO:0060208 name: proestrus namespace: biological_process def: "The estrous cycle phase in which there is heightened follicular activity." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0060206 ! estrous cycle phase [Term] id: GO:0060209 name: estrus namespace: biological_process def: "The estrous cycle phase in which a female is sexually receptive." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "oestrus" EXACT [] is_a: GO:0060206 ! estrous cycle phase [Term] id: GO:0060210 name: metestrus namespace: biological_process def: "The estrous cycle phase in which there is subsiding follicular function." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0060206 ! estrous cycle phase [Term] id: GO:0060211 name: regulation of nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] synonym: "regulation of 3' to 5' mRNA deadenylation" RELATED [] synonym: "regulation of mRNA deadenylation" RELATED [] synonym: "regulation of nuclear mRNA poly(A) tail shortening" RELATED [] is_a: GO:0031440 ! regulation of mRNA 3'-end processing is_a: GO:0061013 ! regulation of mRNA catabolic process relationship: regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening [Term] id: GO:0060212 name: negative regulation of nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] synonym: "negative regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nuclear mRNA poly(A) tail shortening" RELATED [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0031441 ! negative regulation of mRNA 3'-end processing is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening relationship: negatively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening [Term] id: GO:0060213 name: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] synonym: "positive regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of nuclear mRNA poly(A) tail shortening" RELATED [] is_a: GO:0031442 ! positive regulation of mRNA 3'-end processing is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening is_a: GO:0061014 ! positive regulation of mRNA catabolic process relationship: positively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening [Term] id: GO:0060214 name: endocardium formation namespace: biological_process def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003160 ! endocardium morphogenesis [Term] id: GO:0060215 name: primitive hemopoiesis namespace: biological_process def: "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691] synonym: "primitive haematopoiesis" EXACT [] synonym: "primitive haemopoiesis" EXACT [] synonym: "primitive hematopoiesis" RELATED [] is_a: GO:0035162 ! embryonic hemopoiesis [Term] id: GO:0060216 name: definitive hemopoiesis namespace: biological_process def: "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691] synonym: "definitive haematopoiesis" RELATED [] synonym: "definitive haemopoiesis" EXACT [] synonym: "definitive hematopoiesis" EXACT [] is_a: GO:0030097 ! hemopoiesis [Term] id: GO:0060217 name: hemangioblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages." [GOC:bf, GOC:dph, PMID:15378083, PMID:9670018] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060215 ! primitive hemopoiesis [Term] id: GO:0060218 name: hemopoietic stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hemopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:dph, PMID:15378083] synonym: "haematopoietic stem cell differentiation" EXACT [] synonym: "haemopoietic stem cell differentiation" EXACT [] synonym: "hematopoietic stem cell differentiation" EXACT [] is_a: GO:0048863 ! stem cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0060219 name: camera-type eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001754 ! eye photoreceptor cell differentiation relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0060220 name: camera-type eye photoreceptor cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye." [GOC:dph] is_a: GO:0042706 ! eye photoreceptor cell fate commitment relationship: part_of GO:0060219 ! camera-type eye photoreceptor cell differentiation [Term] id: GO:0060221 name: retinal rod cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation [Term] id: GO:0060222 name: regulation of retinal cone cell fate commitment namespace: biological_process def: "Any process that modulates the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0061074 ! regulation of neural retina development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0046551 ! retinal cone cell fate commitment [Term] id: GO:0060223 name: retinal rod cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment relationship: part_of GO:0060221 ! retinal rod cell differentiation [Term] id: GO:0060224 name: regulation of retinal rod cell fate commitment namespace: biological_process def: "Any process that modulates the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0061074 ! regulation of neural retina development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0060223 ! retinal rod cell fate commitment [Term] id: GO:0060225 name: positive regulation of retinal rod cell fate commitment namespace: biological_process def: "Any process that increases the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation is_a: GO:0060224 ! regulation of retinal rod cell fate commitment relationship: positively_regulates GO:0060223 ! retinal rod cell fate commitment [Term] id: GO:0060226 name: negative regulation of retinal cone cell fate commitment namespace: biological_process def: "Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation is_a: GO:0060222 ! regulation of retinal cone cell fate commitment relationship: negatively_regulates GO:0046551 ! retinal cone cell fate commitment [Term] id: GO:0060227 name: Notch signaling pathway involved in camera-type eye photoreceptor fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a precursor cell to a eye photoreceptor fate." [GOC:dph] synonym: "Notch signalling pathway involved in camera-type eye photoreceptor fate commitment" EXACT [GOC:mah] is_a: GO:0007219 ! Notch signaling pathway relationship: part_of GO:0060220 ! camera-type eye photoreceptor cell fate commitment [Term] id: GO:0060228 name: phosphatidylcholine-sterol O-acyltransferase activator activity namespace: molecular_function def: "Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines." [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615] synonym: "LCAT activator activity" NARROW [GOC:tb] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0060229 name: lipase activator activity namespace: molecular_function def: "Increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0060230 name: lipoprotein lipase activator activity namespace: molecular_function def: "Increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein." [GOC:BHF, GOC:dph, GOC:tb, PMID:10727238] is_a: GO:0060229 ! lipase activator activity [Term] id: GO:0060231 name: mesenchymal to epithelial transition namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph] is_a: GO:0003382 ! epithelial cell morphogenesis [Term] id: GO:0060232 name: delamination namespace: biological_process def: "The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170] is_a: GO:0022408 ! negative regulation of cell-cell adhesion [Term] id: GO:0060233 name: oenocyte delamination namespace: biological_process def: "The negative regulation of cell adhesion process in which an oenocyte splits off of an existing epithelial sheet." [GOC:dph] is_a: GO:0060232 ! delamination [Term] id: GO:0060234 name: neuroblast delamination namespace: biological_process def: "The negative regulation of cell adhesion process in which a neuroblast slits off of a neurectodermal sheet." [GOC:dph] is_a: GO:0060232 ! delamination [Term] id: GO:0060235 name: lens induction in camera-type eye namespace: biological_process def: "Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens." [GOC:dph, ISBN:0878932437] is_a: GO:0031128 ! developmental induction relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye [Term] id: GO:0060236 name: regulation of mitotic spindle organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mitotic spindle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0090224 ! regulation of spindle organization relationship: regulates GO:0007052 ! mitotic spindle organization [Term] id: GO:0060237 name: regulation of fungal-type cell wall organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:tb] synonym: "regulation of fungal-type cell wall organization and biogenesis" RELATED [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0031505 ! fungal-type cell wall organization [Term] id: GO:0060238 name: regulation of signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0031137 ! regulation of conjugation with cellular fusion is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0032005 ! regulation of conjugation with cellular fusion by signal transduction [Term] id: GO:0060239 name: positive regulation of signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0032005 ! regulation of conjugation with cellular fusion by signal transduction [Term] id: GO:0060240 name: negative regulation of signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0032005 ! regulation of conjugation with cellular fusion by signal transduction [Term] id: GO:0060241 name: lysozyme inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a lysozyme, an enzyme that hydrolyses the beta- (1,4) glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan." [GOC:dph] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0060242 name: contact inhibition namespace: biological_process def: "The cellular process in which cells stop growing or dividing in response to increased cell density." [GOC:dph, PMID:17376520] xref: Wikipedia:Contact_inhibition is_a: GO:0009987 ! cellular process [Term] id: GO:0060243 name: negative regulation of cell growth involved in contact inhibition namespace: biological_process def: "The negative regulation of cell growth in response to increased cell density." [GOC:dph] is_a: GO:0030308 ! negative regulation of cell growth relationship: part_of GO:0060242 ! contact inhibition [Term] id: GO:0060244 name: negative regulation of cell proliferation involved in contact inhibition namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell proliferation relationship: part_of GO:0060242 ! contact inhibition [Term] id: GO:0060245 name: detection of cell density namespace: biological_process def: "The series of events in which information about the density of cells in a population is received and converted into a molecular signal." [GOC:dph] is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0060246 name: detection of cell density by contact stimulus namespace: biological_process def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal." [GOC:dph] is_a: GO:0060245 ! detection of cell density [Term] id: GO:0060247 name: detection of cell density by secreted molecule namespace: biological_process def: "The series of events in which information about the density of cells in a population is received by the detection of a secreted molecule and is converted into a molecular signal." [GOC:dph] is_a: GO:0060245 ! detection of cell density [Term] id: GO:0060248 name: detection of cell density by contact stimulus involved in contact inhibition namespace: biological_process def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation." [GOC:dph] is_a: GO:0060246 ! detection of cell density by contact stimulus relationship: part_of GO:0060242 ! contact inhibition [Term] id: GO:0060249 name: anatomical structure homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph] synonym: "anatomical structure maintenance" EXACT [GOC:dph] is_a: GO:0042592 ! homeostatic process [Term] id: GO:0060250 name: germ-line stem-cell niche homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph] synonym: "germ-line stem-cell niche maintenance" EXACT [GOC:dph, GOC:tb] synonym: "maintenance of germ line stem cell niche" EXACT [GOC:dph] synonym: "maintenance of germ line stem-cell niche" EXACT [GOC:dph] synonym: "maintenance of germ-line stem cell niche" EXACT [GOC:dph] synonym: "maintenance of germ-line stem-cell niche" EXACT [GOC:dph] is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0060251 name: regulation of glial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0014009 ! glial cell proliferation [Term] id: GO:0060252 name: positive regulation of glial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation relationship: positively_regulates GO:0014009 ! glial cell proliferation [Term] id: GO:0060253 name: negative regulation of glial cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation relationship: negatively_regulates GO:0014009 ! glial cell proliferation [Term] id: GO:0060254 name: regulation of N-terminal protein palmitoylation namespace: biological_process def: "Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0050746 ! regulation of lipoprotein metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0006500 ! N-terminal protein palmitoylation [Term] id: GO:0060255 name: regulation of macromolecule metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0060256 name: regulation of flocculation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb] is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0000128 ! flocculation [Term] id: GO:0060257 name: negative regulation of flocculation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0060256 ! regulation of flocculation relationship: negatively_regulates GO:0000128 ! flocculation [Term] id: GO:0060258 name: negative regulation of filamentous growth namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb] is_a: GO:0010570 ! regulation of filamentous growth is_a: GO:0045926 ! negative regulation of growth relationship: negatively_regulates GO:0030447 ! filamentous growth [Term] id: GO:0060259 name: regulation of feeding behavior namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb] is_a: GO:0050795 ! regulation of behavior relationship: regulates GO:0007631 ! feeding behavior [Term] id: GO:0060260 name: regulation of transcription initiation from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:2000142 ! regulation of transcription initiation, DNA-dependent relationship: regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0060261 name: positive regulation of transcription initiation from RNA polymerase II promoter namespace: biological_process def: "Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb] is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter is_a: GO:2000144 ! positive regulation of transcription initiation, DNA-dependent relationship: positively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0060262 name: negative regulation of N-terminal protein palmitoylation namespace: biological_process def: "Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process is_a: GO:0060254 ! regulation of N-terminal protein palmitoylation relationship: negatively_regulates GO:0006500 ! N-terminal protein palmitoylation [Term] id: GO:0060263 name: regulation of respiratory burst namespace: biological_process def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0045730 ! respiratory burst [Term] id: GO:0060264 name: regulation of respiratory burst involved in inflammatory response namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "regulation of respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060263 ! regulation of respiratory burst relationship: regulates GO:0002536 ! respiratory burst involved in inflammatory response [Term] id: GO:0060265 name: positive regulation of respiratory burst involved in inflammatory response namespace: biological_process def: "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response is_a: GO:0060267 ! positive regulation of respiratory burst relationship: positively_regulates GO:0002536 ! respiratory burst involved in inflammatory response [Term] id: GO:0060266 name: negative regulation of respiratory burst involved in inflammatory response namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response is_a: GO:0060268 ! negative regulation of respiratory burst is_a: GO:0060284 ! regulation of cell development relationship: negatively_regulates GO:0002536 ! respiratory burst involved in inflammatory response [Term] id: GO:0060267 name: positive regulation of respiratory burst namespace: biological_process def: "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060263 ! regulation of respiratory burst relationship: positively_regulates GO:0045730 ! respiratory burst [Term] id: GO:0060268 name: negative regulation of respiratory burst namespace: biological_process def: "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060263 ! regulation of respiratory burst relationship: negatively_regulates GO:0045730 ! respiratory burst [Term] id: GO:0060269 name: centripetally migrating follicle cell migration namespace: biological_process def: "The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte." [GOC:dph] is_a: GO:0007297 ! ovarian follicle cell migration [Term] id: GO:0060270 name: main body follicle cell migration namespace: biological_process def: "The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte." [GOC:dph] is_a: GO:0007297 ! ovarian follicle cell migration [Term] id: GO:0060271 name: cilium morphogenesis namespace: biological_process def: "A process that is carried out at the cellular level and in which the structure of a cilium is organized." [GOC:BHF, GOC:dph] synonym: "cilium organization" RELATED [GOC:dph] is_a: GO:0048858 ! cell projection morphogenesis [Term] id: GO:0060272 name: embryonic skeletal joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A joint is the connecting structure between the bones of the skeleton." [GOC:BHF, GOC:dph] is_a: GO:0048704 ! embryonic skeletal system morphogenesis relationship: part_of GO:0072498 ! embryonic skeletal joint development [Term] id: GO:0060273 name: crying behavior namespace: biological_process def: "The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli." [GOC:dph] is_a: GO:0007610 ! behavior [Term] id: GO:0060274 name: maintenance of stationary phase namespace: biological_process def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrients or a build-up of toxic substances in the environment." [GOC:dph] is_a: GO:0048874 ! homeostasis of number of cells in a free-living population [Term] id: GO:0060275 name: maintenance of stationary phase in response to starvation namespace: biological_process def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment." [GOC:dph] is_a: GO:0042594 ! response to starvation is_a: GO:0060274 ! maintenance of stationary phase [Term] id: GO:0060276 name: maintenance of stationary phase in response to toxin namespace: biological_process def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment." [GOC:dph] is_a: GO:0009636 ! response to toxin is_a: GO:0060274 ! maintenance of stationary phase [Term] id: GO:0060277 name: negative regulation of transcription involved in G1 phase of mitotic cell cycle namespace: biological_process def: "Any process that stop, prevents or decreases transcription as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:tb] synonym: "negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0000114 ! regulation of transcription involved in G1 phase of mitotic cell cycle is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter [Term] id: GO:0060278 name: regulation of ovulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0030728 ! ovulation [Term] id: GO:0060279 name: positive regulation of ovulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060278 ! regulation of ovulation is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0030728 ! ovulation [Term] id: GO:0060280 name: negative regulation of ovulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060278 ! regulation of ovulation is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0030728 ! ovulation [Term] id: GO:0060281 name: regulation of oocyte development namespace: biological_process def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0048599 ! oocyte development [Term] id: GO:0060282 name: positive regulation of oocyte development namespace: biological_process def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0048599 ! oocyte development [Term] id: GO:0060283 name: negative regulation of oocyte development namespace: biological_process def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0048599 ! oocyte development [Term] id: GO:0060284 name: regulation of cell development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0048468 ! cell development [Term] id: GO:0060285 name: ciliary cell motility namespace: biological_process def: "Cell motility due to the motion of one or more cilia." [GOC:dgh, GOC:dph, GOC:mlg] is_a: GO:0001539 ! ciliary or flagellar motility [Term] id: GO:0060286 name: flagellar cell motility namespace: biological_process def: "Cell motility due to the motion of one or more flagella." [GOC:dgh, GOC:dph, GOC:mlg] is_a: GO:0001539 ! ciliary or flagellar motility [Term] id: GO:0060287 name: cilium movement involved in determination of left/right asymmetry namespace: biological_process def: "The movement of cilia of epithelial cells resulting in the transport of signals which determine asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:mlg] synonym: "cilium movement involved in determinationof L/R asymmetry" EXACT [] is_a: GO:0003351 ! epithelial cilium movement relationship: part_of GO:0007368 ! determination of left/right symmetry [Term] id: GO:0060288 name: formation of a compartment boundary namespace: biological_process def: "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] synonym: "compartment boundary formation" EXACT [] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007386 ! compartment pattern formation [Term] id: GO:0060289 name: compartment boundary maintenance namespace: biological_process def: "A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] is_a: GO:0001894 ! tissue homeostasis relationship: part_of GO:0007386 ! compartment pattern formation [Term] id: GO:0060290 name: transdifferentiation namespace: biological_process def: "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate." [GOC:dph, GOC:kmv] xref: Wikipedia:Transdifferentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0060291 name: long-term synaptic potentiation namespace: biological_process def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph] synonym: "long-term potentiation" BROAD [GOC:dph] synonym: "LTP" RELATED [GOC:dph] is_a: GO:0048167 ! regulation of synaptic plasticity is_a: GO:0050806 ! positive regulation of synaptic transmission [Term] id: GO:0060292 name: long term synaptic depression namespace: biological_process def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph] synonym: "long term depression" BROAD [GOC:dph] synonym: "LTD" RELATED [GOC:dph] is_a: GO:0048167 ! regulation of synaptic plasticity is_a: GO:0050805 ! negative regulation of synaptic transmission [Term] id: GO:0060293 name: germ plasm namespace: cellular_component def: "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line." [GOC:dph] xref: Wikipedia:Germ_plasm is_a: GO:0045495 ! pole plasm [Term] id: GO:0060294 name: cilium movement involved in cell motility namespace: biological_process def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement relationship: part_of GO:0060285 ! ciliary cell motility [Term] id: GO:0060295 name: regulation of cilium movement involved in cell motility namespace: biological_process def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:2000145 ! regulation of cell motility relationship: regulates GO:0060294 ! cilium movement involved in cell motility [Term] id: GO:0060296 name: regulation of cilium beat frequency involved in ciliary motility namespace: biological_process def: "Any process that modulates the frequency of cilium beating involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0060295 ! regulation of cilium movement involved in cell motility is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0060297 name: regulation of sarcomere organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0045214 ! sarcomere organization [Term] id: GO:0060298 name: positive regulation of sarcomere organization namespace: biological_process def: "Any process that increases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization relationship: positively_regulates GO:0045214 ! sarcomere organization [Term] id: GO:0060299 name: negative regulation of sarcomere organization namespace: biological_process def: "Any process that decreases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization relationship: negatively_regulates GO:0045214 ! sarcomere organization [Term] id: GO:0060300 name: regulation of cytokine activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0043393 ! regulation of protein binding [Term] id: GO:0060301 name: positive regulation of cytokine activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:0060300 ! regulation of cytokine activity [Term] id: GO:0060302 name: negative regulation of cytokine activity namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:0060300 ! regulation of cytokine activity [Term] id: GO:0060303 name: regulation of nucleosome density namespace: biological_process def: "Any process that modulates the number of nucleosomes in a given region of a chromosome." [GOC:dph, GOC:tb] is_a: GO:0034728 ! nucleosome organization is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0060304 name: regulation of phosphatidylinositol dephosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol." [GOC:dph, GOC:tb] synonym: "regulation of phosphoinositide dephosphorylation" EXACT [GOC:curators] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0035303 ! regulation of dephosphorylation is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0046856 ! phosphatidylinositol dephosphorylation [Term] id: GO:0060305 name: regulation of cell diameter namespace: biological_process def: "Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell." [GOC:dph, GOC:tb] synonym: "regulation of cell width" BROAD [GOC:dph, GOC:tb] is_a: GO:0008361 ! regulation of cell size [Term] id: GO:0060306 name: regulation of membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0060307 name: regulation of ventricular cardiomyocyte membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte." [GOC:BHF, GOC:dph, GOC:tb] synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb] synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb] is_a: GO:0055117 ! regulation of cardiac muscle contraction is_a: GO:0060306 ! regulation of membrane repolarization [Term] id: GO:0060308 name: GTP cyclohydrolase I regulator activity namespace: molecular_function def: "Modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0060309 name: elastin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [GOC:BHF, GOC:dph, GOC:tb] synonym: "elastin breakdown" EXACT [] synonym: "elastin catabolism" EXACT [] synonym: "elastin degradation" EXACT [] is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0051541 ! elastin metabolic process [Term] id: GO:0060310 name: regulation of elastin catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of elastin breakdown" RELATED [GOC:dph, GOC:tb] synonym: "regulation of elastin catabolism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of elastin degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0060309 ! elastin catabolic process [Term] id: GO:0060311 name: negative regulation of elastin catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down-regulation of elastin catabolic process" EXACT [] synonym: "negative regulation of elastin breakdown" EXACT [] synonym: "negative regulation of elastin catabolism" EXACT [] synonym: "negative regulation of elastin degradation" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0060310 ! regulation of elastin catabolic process relationship: negatively_regulates GO:0060309 ! elastin catabolic process [Term] id: GO:0060312 name: regulation of blood vessel remodeling namespace: biological_process def: "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0034103 ! regulation of tissue remodeling relationship: regulates GO:0001974 ! blood vessel remodeling [Term] id: GO:0060313 name: negative regulation of blood vessel remodeling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down-regulation of blood vessel remodeling" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of blood vessel remodeling" NARROW [GOC:dph, GOC:tb] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0060312 ! regulation of blood vessel remodeling relationship: negatively_regulates GO:0001974 ! blood vessel remodeling [Term] id: GO:0060314 name: regulation of ryanodine-sensitive calcium-release channel activity namespace: biological_process def: "Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0051924 ! regulation of calcium ion transport [Term] id: GO:0060315 name: negative regulation of ryanodine-sensitive calcium-release channel activity namespace: biological_process def: "Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity [Term] id: GO:0060316 name: positive regulation of ryanodine-sensitive calcium-release channel activity namespace: biological_process def: "Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity [Term] id: GO:0060317 name: cardiac epithelial to mesenchymal transition namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, PMID:16314491, PMID:1996351] synonym: "heart epithelial to mesenchymal transition" EXACT [] is_a: GO:0001837 ! epithelial to mesenchymal transition relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0060318 name: definitive erythrocyte differentiation namespace: biological_process def: "Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph] synonym: "definitive erythropoiesis" EXACT [] synonym: "definitive RBC differentiation" EXACT [CL:0000232] synonym: "definitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation relationship: part_of GO:0060216 ! definitive hemopoiesis [Term] id: GO:0060319 name: primitive erythrocyte differentiation namespace: biological_process def: "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph] synonym: "primitive erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "primitive RBC differentiation" EXACT [CL:0000232] synonym: "primitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation relationship: part_of GO:0060215 ! primitive hemopoiesis [Term] id: GO:0060320 name: rejection of self pollen namespace: biological_process def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the rejection of the self pollen by cells in the stigma." [GOC:dph, GOC:tb] is_a: GO:0048544 ! recognition of pollen [Term] id: GO:0060321 name: acceptance of pollen namespace: biological_process def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the acceptance of pollen by cells in the stigma." [GOC:dph, GOC:tb] synonym: "acceptance of non-self pollen" RELATED [GOC:dph, GOC:tb] synonym: "acceptance of self pollen" NARROW [GOC:dph, GOC:tb] is_a: GO:0048544 ! recognition of pollen [Term] id: GO:0060322 name: head development namespace: biological_process def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0060323 name: head morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0010171 ! body morphogenesis relationship: part_of GO:0060322 ! head development [Term] id: GO:0060324 name: face development namespace: biological_process def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060322 ! head development [Term] id: GO:0060325 name: face morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060323 ! head morphogenesis relationship: part_of GO:0060324 ! face development [Term] id: GO:0060326 name: cell chemotaxis namespace: biological_process def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph] is_a: GO:0006935 ! chemotaxis is_a: GO:0016477 ! cell migration is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0060327 name: cytoplasmic actin-based contraction involved in cell motility namespace: biological_process def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another." [GOC:dph] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0048870 ! cell motility [Term] id: GO:0060328 name: cytoplasmic actin-based contraction involved in forward cell motility namespace: biological_process def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell." [GOC:dph] synonym: "cytoplasmic actin-based contraction involved in forward cell locomotion" RELATED [] is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility [Term] id: GO:0060329 name: cytoplasmic actin-based contraction involved in rearward cell motility namespace: biological_process def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell." [GOC:dph] synonym: "cytoplasmic actin-based contraction involved in rearward cell locomotion" RELATED [] is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility [Term] id: GO:0060330 name: regulation of response to interferon-gamma namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] synonym: "regulation of response to gamma-interferon" RELATED [] synonym: "regulation of response to immune interferon" EXACT [] synonym: "regulation of response to type II IFN" EXACT [] synonym: "regulation of response to type II interferon" EXACT [] is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0060759 ! regulation of response to cytokine stimulus relationship: regulates GO:0034341 ! response to interferon-gamma [Term] id: GO:0060331 name: negative regulation of response to interferon-gamma namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] synonym: "negative regulation of response to gamma-interferon" RELATED [] synonym: "negative regulation of response to immune interferon" EXACT [] synonym: "negative regulation of response to type II IFN" EXACT [] synonym: "negative regulation of response to type II interferon" EXACT [] is_a: GO:0060330 ! regulation of response to interferon-gamma is_a: GO:0060761 ! negative regulation of response to cytokine stimulus relationship: negatively_regulates GO:0034341 ! response to interferon-gamma [Term] id: GO:0060332 name: positive regulation of response to interferon-gamma namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] synonym: "positive regulation of response to gamma-interferon" RELATED [] synonym: "positive regulation of response to immune interferon" EXACT [] synonym: "positive regulation of response to type II IFN" EXACT [] synonym: "positive regulation of response to type II interferon" EXACT [] is_a: GO:0060330 ! regulation of response to interferon-gamma is_a: GO:0060760 ! positive regulation of response to cytokine stimulus relationship: positively_regulates GO:0034341 ! response to interferon-gamma [Term] id: GO:0060333 name: interferon-gamma-mediated signaling pathway namespace: biological_process def: "A series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:add, GOC:dph] synonym: "gamma-interferon-mediated signaling pathway" EXACT [GOC:dph] synonym: "immune interferon signaling pathway" EXACT [GOC:dph] synonym: "interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] synonym: "type II IFN-mediated signaling pathway" RELATED [] synonym: "type II interferon-mediated signaling pathway" EXACT [GOC:dph] xref: Reactome:877300 "Interferon gamma signaling" is_a: GO:0019221 ! cytokine-mediated signaling pathway is_a: GO:0071346 ! cellular response to interferon-gamma [Term] id: GO:0060334 name: regulation of interferon-gamma-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] synonym: "regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] synonym: "regulation of immune interferon signaling pathway" EXACT [GOC:dph] synonym: "regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] synonym: "regulation of type II IFN-mediated signaling pathway" EXACT [GOC:dph] synonym: "regulation of type II interferon-mediated signaling pathway" EXACT [GOC:dph] xref: Reactome:877312 "Regulation of IFNG signaling" is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0060330 ! regulation of response to interferon-gamma relationship: regulates GO:0060333 ! interferon-gamma-mediated signaling pathway [Term] id: GO:0060335 name: positive regulation of interferon-gamma-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] synonym: "positive regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] synonym: "positive regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph] synonym: "positive regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of type II IFN-mediated pathway" EXACT [GOC:dph] synonym: "positive regulation of type II interferon-mediated signaling pathway" EXACT [GOC:dph] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0060332 ! positive regulation of response to interferon-gamma is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway relationship: positively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway [Term] id: GO:0060336 name: negative regulation of interferon-gamma-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] synonym: "negative regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] synonym: "negative regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph] synonym: "negative regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of type II IFN-mediated signaling pathway" EXACT [GOC:dph] synonym: "negative regulation of type II interferon-mediated signaling pathway" EXACT [GOC:dph] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0060331 ! negative regulation of response to interferon-gamma is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway relationship: negatively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway [Term] id: GO:0060337 name: type I interferon-mediated signaling pathway namespace: biological_process def: "A series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph] synonym: "type I interferon-mediated signalling pathway" EXACT [GOC:mah] xref: Reactome:909733 "Interferon alpha/beta signaling" is_a: GO:0019221 ! cytokine-mediated signaling pathway is_a: GO:0071357 ! cellular response to type I interferon [Term] id: GO:0060338 name: regulation of type I interferon-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] synonym: "regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah] xref: Reactome:912694 "Regulation of IFNA signaling" is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0060337 ! type I interferon-mediated signaling pathway [Term] id: GO:0060339 name: negative regulation of type I interferon-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] synonym: "negative regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway relationship: negatively_regulates GO:0060337 ! type I interferon-mediated signaling pathway [Term] id: GO:0060340 name: positive regulation of type I interferon-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] synonym: "positive regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway relationship: positively_regulates GO:0060337 ! type I interferon-mediated signaling pathway [Term] id: GO:0060341 name: regulation of cellular localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] synonym: "regulation of cellular localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0051641 ! cellular localization [Term] id: GO:0060342 name: photoreceptor inner segment membrane namespace: cellular_component def: "The membrane surrounding the outer segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:dph] is_a: GO:0016020 ! membrane relationship: part_of GO:0001917 ! photoreceptor inner segment [Term] id: GO:0060343 name: trabecula formation namespace: biological_process def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] synonym: "trabecula biogenesis" RELATED [GOC:dph] synonym: "trabeculation" EXACT [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0009887 ! organ morphogenesis relationship: part_of GO:0061383 ! trabecula morphogenesis [Term] id: GO:0060344 name: liver trabecula formation namespace: biological_process def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "liver trabecula biogenesis" RELATED [] synonym: "liver trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation relationship: part_of GO:0001889 ! liver development [Term] id: GO:0060345 name: spleen trabecula formation namespace: biological_process def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "spleen trabecula biogenesis" RELATED [GOC:dph] synonym: "spleen trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation relationship: part_of GO:0048536 ! spleen development [Term] id: GO:0060346 name: bone trabecula formation namespace: biological_process def: "The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "bone trabecula biogenesis" RELATED [GOC:dph] synonym: "bone trabeculation" EXACT [GOC:dph] synonym: "skeletal trabecula biogenesis" RELATED [GOC:dph] synonym: "skeletal trabecula formation" EXACT [GOC:dph] synonym: "skeletal trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation relationship: part_of GO:0048705 ! skeletal system morphogenesis [Term] id: GO:0060347 name: heart trabecula formation namespace: biological_process def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "cardiac trabecula formation" EXACT [GOC:dph] synonym: "cardiac trabeculation" EXACT [GOC:dph] synonym: "heart trabecula biogenesis" RELATED [GOC:dph] synonym: "heart trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation relationship: part_of GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0061384 ! heart trabecular morphogenesis [Term] id: GO:0060348 name: bone development namespace: biological_process def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001501 ! skeletal system development [Term] id: GO:0060349 name: bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0060348 ! bone development [Term] id: GO:0060350 name: endochondral bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679] is_a: GO:0060349 ! bone morphogenesis [Term] id: GO:0060351 name: cartilage development involved in endochondral bone morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph] is_a: GO:0051216 ! cartilage development relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0060352 name: cell adhesion molecule production namespace: biological_process def: "The appearance of a cell adhesion molecule due to biosynthesis or secretion." [GOC:BHF, GOC:rl] is_a: GO:0009987 ! cellular process [Term] id: GO:0060353 name: regulation of cell adhesion molecule production namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0060352 ! cell adhesion molecule production [Term] id: GO:0060354 name: negative regulation of cell adhesion molecule production namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0060353 ! regulation of cell adhesion molecule production relationship: negatively_regulates GO:0060352 ! cell adhesion molecule production [Term] id: GO:0060355 name: positive regulation of cell adhesion molecule production namespace: biological_process def: "Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0060353 ! regulation of cell adhesion molecule production relationship: positively_regulates GO:0060352 ! cell adhesion molecule production [Term] id: GO:0060356 name: leucine import namespace: biological_process def: "The directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] synonym: "L-leucine import" NARROW [] synonym: "L-leucine uptake" NARROW [] synonym: "leucine uptake" EXACT [] is_a: GO:0015820 ! leucine transport is_a: GO:0043090 ! amino acid import [Term] id: GO:0060357 name: regulation of leucine import namespace: biological_process def: "Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] synonym: "regulation of L-leucine import" NARROW [GOC:dph, GOC:tb] synonym: "regulation of L-leucine uptake" NARROW [GOC:dph, GOC:tb] synonym: "regulation of leucine uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0010958 ! regulation of amino acid import relationship: regulates GO:0060356 ! leucine import [Term] id: GO:0060358 name: negative regulation of leucine import namespace: biological_process def: "Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:0060357 ! regulation of leucine import relationship: negatively_regulates GO:0060356 ! leucine import [Term] id: GO:0060359 name: response to ammonium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:dph, GOC:tb] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0060360 name: negative regulation of leucine import in response to ammonium ion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of leucine uptake in response to ammonium ion" EXACT [] is_a: GO:0060358 ! negative regulation of leucine import is_a: GO:0071242 ! cellular response to ammonium ion [Term] id: GO:0060361 name: flight namespace: biological_process def: "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] is_a: GO:0040011 ! locomotion [Term] id: GO:0060362 name: flight involved in flight behavior namespace: biological_process def: "Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight." [GOC:dph] is_a: GO:0031987 ! locomotion involved in locomotory behavior is_a: GO:0060361 ! flight relationship: part_of GO:0007629 ! flight behavior [Term] id: GO:0060363 name: cranial suture morphogenesis namespace: biological_process def: "The process in which the cranial suture is generated and organized." [GOC:dph, GOC:sl] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060349 ! bone morphogenesis [Term] id: GO:0060364 name: frontal suture morphogenesis namespace: biological_process def: "The process in which the frontal suture is generated and organized." [GOC:dph, GOC:sl] is_a: GO:0060363 ! cranial suture morphogenesis [Term] id: GO:0060365 name: coronal suture morphogenesis namespace: biological_process def: "The process in which the coronal suture is generated and organized." [GOC:dph, GOC:sl] is_a: GO:0060363 ! cranial suture morphogenesis [Term] id: GO:0060366 name: lambdoid suture morphogenesis namespace: biological_process def: "The process in which the lambdoid suture is generated and organized." [GOC:dph, GOC:sl] is_a: GO:0060363 ! cranial suture morphogenesis [Term] id: GO:0060367 name: sagittal suture morphogenesis namespace: biological_process def: "The process in which the sagittal suture is generated and organized." [GOC:dph, GOC:sl] is_a: GO:0060363 ! cranial suture morphogenesis [Term] id: GO:0060368 name: regulation of Fc receptor mediated stimulatory signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:dph, GOC:tb] synonym: "regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway [Term] id: GO:0060369 name: positive regulation of Fc receptor mediated stimulatory signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060368 ! regulation of Fc receptor mediated stimulatory signaling pathway relationship: positively_regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway [Term] id: GO:0060370 name: susceptibility to T cell mediated cytotoxicity namespace: biological_process def: "The process of causing a cell to become susceptible to T cell mediated cytotoxicity." [GOC:dph, GOC:tb] is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity [Term] id: GO:0060371 name: regulation of atrial cardiomyocyte membrane depolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb] synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb] synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb] synonym: "regulation of atrial cardiac muscle cell depolarization" EXACT [GOC:dph, GOC:tb] is_a: GO:0003254 ! regulation of membrane depolarization is_a: GO:0055117 ! regulation of cardiac muscle contraction [Term] id: GO:0060372 name: regulation of atrial cardiomyocyte membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb] synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb] synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] synonym: "regulation of atrial cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb] is_a: GO:0055117 ! regulation of cardiac muscle contraction is_a: GO:0060306 ! regulation of membrane repolarization [Term] id: GO:0060373 name: regulation of ventricular cardiomyocyte membrane depolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte." [GOC:dph, GOC:tb] synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiac muscle cell membrane depolarization" EXACT [] synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb] is_a: GO:0003254 ! regulation of membrane depolarization is_a: GO:0055117 ! regulation of cardiac muscle contraction [Term] id: GO:0060374 name: mast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0060375 name: regulation of mast cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation relationship: regulates GO:0060374 ! mast cell differentiation [Term] id: GO:0060376 name: positive regulation of mast cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0060375 ! regulation of mast cell differentiation relationship: positively_regulates GO:0060374 ! mast cell differentiation [Term] id: GO:0060377 name: negative regulation of mast cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0060375 ! regulation of mast cell differentiation relationship: negatively_regulates GO:0060374 ! mast cell differentiation [Term] id: GO:0060378 name: regulation of brood size namespace: biological_process def: "Any process that modulates the extent of brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:dph, GOC:tb] is_a: GO:0048609 ! multicellular organismal reproductive process is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0060379 name: cardiac muscle cell myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb] synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb] synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation [Term] id: GO:0060380 name: regulation of single-stranded telomeric DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA." [GOC:dph, GOC:tb] synonym: "regulation of telomeric ssDNA binding" EXACT [GOC:mah] is_a: GO:0051101 ! regulation of DNA binding [Term] id: GO:0060381 name: positive regulation of single-stranded telomeric DNA binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of telomeric ssDNA binding" EXACT [GOC:mah] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:0060380 ! regulation of single-stranded telomeric DNA binding [Term] id: GO:0060382 name: regulation of DNA strand elongation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:dph, GOC:tb] is_a: GO:0051052 ! regulation of DNA metabolic process relationship: regulates GO:0022616 ! DNA strand elongation [Term] id: GO:0060383 name: positive regulation of DNA strand elongation namespace: biological_process def: "Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:0060382 ! regulation of DNA strand elongation relationship: positively_regulates GO:0022616 ! DNA strand elongation [Term] id: GO:0060384 name: innervation namespace: biological_process def: "The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue." [GOC:dph, GOC:sart] is_a: GO:0032502 ! developmental process relationship: part_of GO:0021675 ! nerve development [Term] id: GO:0060385 name: axonogenesis involved in innervation namespace: biological_process def: "The neurite development process that generates a long process of a neuron, as it invades a target tissue." [GOC:dph, GOC:sart] is_a: GO:0007409 ! axonogenesis relationship: part_of GO:0060384 ! innervation [Term] id: GO:0060386 name: synaptogenesis involved in innervation namespace: biological_process def: "The biosynthesis of a synapse within a target tissue in which a nerve is invading." [GOC:dph, GOC:sart] is_a: GO:0007416 ! synapse assembly relationship: part_of GO:0060384 ! innervation [Term] id: GO:0060387 name: fertilization envelope namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release." [GOC:dph, ISBN:0878932437] synonym: "fertilization membrane" RELATED [] is_a: GO:0035805 ! egg coat [Term] id: GO:0060388 name: vitelline envelope namespace: cellular_component def: "A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization." [GOC:dph, ISBN:0878932437] synonym: "fertilization membrane" RELATED [] is_a: GO:0035805 ! egg coat [Term] id: GO:0060389 name: pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor." [GOC:dph, ISBN:3527303782] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0060390 name: regulation of SMAD protein import into nucleus namespace: biological_process def: "Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of SMAD protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0007184 ! SMAD protein import into nucleus [Term] id: GO:0060391 name: positive regulation of SMAD protein import into nucleus namespace: biological_process def: "Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of SMAD protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0042307 ! positive regulation of protein import into nucleus is_a: GO:0060390 ! regulation of SMAD protein import into nucleus is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0007184 ! SMAD protein import into nucleus [Term] id: GO:0060392 name: negative regulation of SMAD protein import into nucleus namespace: biological_process def: "Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of SMAD protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0042308 ! negative regulation of protein import into nucleus is_a: GO:0060390 ! regulation of SMAD protein import into nucleus is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0007184 ! SMAD protein import into nucleus [Term] id: GO:0060393 name: regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation [Term] id: GO:0060394 name: negative regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation [Term] id: GO:0060395 name: SMAD protein signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0060396 name: growth hormone receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph, PMID:11445442] synonym: "cellular response to growth hormone" RELATED [GOC:dph] synonym: "GH receptor signaling pathway" RELATED [GOC:dph] synonym: "growth hormone receptor signalling pathway" EXACT [GOC:dph] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway is_a: GO:0071378 ! cellular response to growth hormone stimulus [Term] id: GO:0060397 name: JAK-STAT cascade involved in growth hormone signaling pathway namespace: biological_process def: "The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GOC:BHF, GOC:dph, PMID:11445442] synonym: "JAK-STAT cascade involved in growth hormone signalling pathway" EXACT [GOC:dph] is_a: GO:0007259 ! JAK-STAT cascade relationship: part_of GO:0060396 ! growth hormone receptor signaling pathway [Term] id: GO:0060398 name: regulation of growth hormone receptor signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph] synonym: "regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0060396 ! growth hormone receptor signaling pathway [Term] id: GO:0060399 name: positive regulation of growth hormone receptor signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph] synonym: "positive regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway relationship: positively_regulates GO:0060396 ! growth hormone receptor signaling pathway [Term] id: GO:0060400 name: negative regulation of growth hormone receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:dph] synonym: "negative regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway relationship: negatively_regulates GO:0060396 ! growth hormone receptor signaling pathway [Term] id: GO:0060401 name: cytosolic calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within the cytosol." [GOC:dph, GOC:tb] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0060402 name: calcium ion transport into cytosol namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into the cytosol." [GOC:dph, GOC:tb] is_a: GO:0007204 ! elevation of cytosolic calcium ion concentration is_a: GO:0060401 ! cytosolic calcium ion transport [Term] id: GO:0060403 name: post-mating oviposition namespace: biological_process def: "The deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb] is_a: GO:0018991 ! oviposition is_a: GO:0045297 ! post-mating behavior [Term] id: GO:0060404 name: axonemal microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:dph, GOC:tb] is_a: GO:0007019 ! microtubule depolymerization [Term] id: GO:0060405 name: regulation of penile erection namespace: biological_process def: "Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0043084 ! penile erection [Term] id: GO:0060406 name: positive regulation of penile erection namespace: biological_process def: "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060405 ! regulation of penile erection is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0043084 ! penile erection [Term] id: GO:0060407 name: negative regulation of penile erection namespace: biological_process def: "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060405 ! regulation of penile erection is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0043084 ! penile erection [Term] id: GO:0060408 name: regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0050804 ! regulation of synaptic transmission is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0008291 ! acetylcholine metabolic process [Term] id: GO:0060409 name: positive regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process relationship: positively_regulates GO:0008291 ! acetylcholine metabolic process [Term] id: GO:0060410 name: negative regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process relationship: negatively_regulates GO:0008291 ! acetylcholine metabolic process [Term] id: GO:0060411 name: cardiac septum morphogenesis namespace: biological_process alt_id: GO:0003280 def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart] synonym: "heart septum morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003279 ! cardiac septum development [Term] id: GO:0060412 name: ventricular septum morphogenesis namespace: biological_process def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph] synonym: "interventricular septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0003281 ! ventricular septum development [Term] id: GO:0060413 name: atrial septum morphogenesis namespace: biological_process alt_id: GO:0003287 def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart] synonym: "atrial septum morphogenesis" EXACT [] synonym: "interatrial septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0003209 ! cardiac atrium morphogenesis relationship: part_of GO:0003283 ! atrial septum development [Term] id: GO:0060414 name: aorta smooth muscle tissue morphogenesis namespace: biological_process def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. The aorta originates in the left ventricle of the heart and transports oxygenated blood to the rest of the body." [GOC:dph] is_a: GO:0060415 ! muscle tissue morphogenesis relationship: part_of GO:0048745 ! smooth muscle tissue development relationship: part_of GO:0048844 ! artery morphogenesis [Term] id: GO:0060415 name: muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0048644 ! muscle organ morphogenesis [Term] id: GO:0060416 name: response to growth hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:BHF, GOC:dph] is_a: GO:0043434 ! response to peptide hormone stimulus [Term] id: GO:0060417 name: yolk namespace: cellular_component def: "The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo." [GOC:dph, GOC:tb, PMID:18046696] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0060418 name: yolk plasma namespace: cellular_component def: "Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:dph, GOC:tb, PMID:18046696] is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0060417 ! yolk [Term] id: GO:0060419 name: heart growth namespace: biological_process def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0035265 ! organ growth relationship: part_of GO:0007507 ! heart development [Term] id: GO:0060420 name: regulation of heart growth namespace: biological_process def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0060419 ! heart growth [Term] id: GO:0060421 name: positive regulation of heart growth namespace: biological_process def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0046622 ! positive regulation of organ growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0060420 ! regulation of heart growth relationship: positively_regulates GO:0060419 ! heart growth [Term] id: GO:0060422 name: peptidyl-dipeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain." [GOC:dph, GOC:tb] is_a: GO:0030414 ! peptidase inhibitor activity [Term] id: GO:0060423 name: foregut regionalization namespace: biological_process def: "The pattern specification process that results in the spatial subdivision of an axis or axes along the foregut to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:dph, GOC:mtg_lung] is_a: GO:0009952 ! anterior/posterior pattern formation [Term] id: GO:0060424 name: lung field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the foregut into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung] synonym: "lung specification" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0010092 ! specification of organ identity is_a: GO:0060423 ! foregut regionalization relationship: part_of GO:0060431 ! primary lung bud formation [Term] id: GO:0060425 name: lung morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060426 name: lung vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0001944 ! vasculature development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060427 name: lung connective tissue development namespace: biological_process def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary connective tissue development" EXACT [] is_a: GO:0009888 ! tissue development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060428 name: lung epithelium development namespace: biological_process def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060429 name: epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] is_a: GO:0009888 ! tissue development [Term] id: GO:0060430 name: lung saccule development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells." [GOC:dph, GOC:mtg_lung] synonym: "lung saccular development" BROAD [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048286 ! lung alveolus development [Term] id: GO:0060431 name: primary lung bud formation namespace: biological_process def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung] synonym: "lung formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048645 ! organ formation is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis is_a: GO:0060572 ! morphogenesis of an epithelial bud [Term] id: GO:0060432 name: lung pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the lung, to which cells respond and eventually are instructed to differentiate." [GOC:dph] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060433 name: bronchus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0048513 ! organ development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0060434 name: bronchus morphogenesis namespace: biological_process def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0060433 ! bronchus development [Term] id: GO:0060435 name: bronchiole development namespace: biological_process def: "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph, GOC:mtg_lung] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060436 name: bronchiole morphogenesis namespace: biological_process def: "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060435 ! bronchiole development [Term] id: GO:0060437 name: lung growth namespace: biological_process def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph] is_a: GO:0035265 ! organ growth relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060438 name: trachea development namespace: biological_process def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048513 ! organ development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0060439 name: trachea morphogenesis namespace: biological_process def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0060438 ! trachea development [Term] id: GO:0060440 name: trachea formation namespace: biological_process def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048645 ! organ formation relationship: part_of GO:0060439 ! trachea morphogenesis [Term] id: GO:0060441 name: epithelial tube branching involved in lung morphogenesis namespace: biological_process def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung] synonym: "lung branching morphogenesis" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of a tube is_a: GO:0060562 ! epithelial tube morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0060425 ! lung morphogenesis [Term] id: GO:0060442 name: branching involved in prostate gland morphogenesis namespace: biological_process def: "The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph] synonym: "prostate branching" RELATED [GOC:dph] synonym: "prostate gland branching morphogenesis" EXACT [GOC:dph] is_a: GO:0060740 ! prostate gland epithelium morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium [Term] id: GO:0060443 name: mammary gland morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph] is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0060444 name: branching involved in mammary gland duct morphogenesis namespace: biological_process def: "The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph] synonym: "mammary gland branching morphogenesis" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of a tube is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0060603 ! mammary gland duct morphogenesis [Term] id: GO:0060445 name: branching involved in salivary gland morphogenesis namespace: biological_process def: "The process in which the branching structure of the salivary gland is generated and organized." [GOC:dph] is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0060446 name: branching involved in open tracheal system development namespace: biological_process def: "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of a tube is_a: GO:0060562 ! epithelial tube morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0060447 name: bud outgrowth involved in lung branching namespace: biological_process def: "The process in which a region of the lung epithelium initiates an outgrowth." [GOC:dph, GOC:mtg_lung] synonym: "bud formation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060602 ! branch elongation of an epithelium relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060448 name: dichotomous subdivision of terminal units involved in lung branching namespace: biological_process def: "The process in which a lung bud bifurcates." [GOC:dph, GOC:mtg_lung] synonym: "bud bifurcation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060449 name: bud elongation involved in lung branching namespace: biological_process def: "The process in which a bud in the lung grows out from the point where it is formed." [GOC:dph, GOC:mtg_lung] is_a: GO:0060602 ! branch elongation of an epithelium relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060450 name: positive regulation of hindgut contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] is_a: GO:0043134 ! regulation of hindgut contraction is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:0060456 ! positive regulation of digestive system process relationship: positively_regulates GO:0043133 ! hindgut contraction [Term] id: GO:0060451 name: negative regulation of hindgut contraction namespace: biological_process def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] is_a: GO:0043134 ! regulation of hindgut contraction is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:0060457 ! negative regulation of digestive system process relationship: negatively_regulates GO:0043133 ! hindgut contraction [Term] id: GO:0060452 name: positive regulation of cardiac muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb] is_a: GO:0045989 ! positive regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction relationship: positively_regulates GO:0060048 ! cardiac muscle contraction [Term] id: GO:0060453 name: regulation of gastric acid secretion namespace: biological_process def: "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051046 ! regulation of secretion relationship: regulates GO:0001696 ! gastric acid secretion [Term] id: GO:0060454 name: positive regulation of gastric acid secretion namespace: biological_process def: "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060453 ! regulation of gastric acid secretion is_a: GO:0060456 ! positive regulation of digestive system process relationship: positively_regulates GO:0001696 ! gastric acid secretion [Term] id: GO:0060455 name: negative regulation of gastric acid secretion namespace: biological_process def: "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060453 ! regulation of gastric acid secretion is_a: GO:0060457 ! negative regulation of digestive system process relationship: negatively_regulates GO:0001696 ! gastric acid secretion [Term] id: GO:0060456 name: positive regulation of digestive system process namespace: biological_process def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0022600 ! digestive system process [Term] id: GO:0060457 name: negative regulation of digestive system process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0022600 ! digestive system process [Term] id: GO:0060458 name: right lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0030324 ! lung development [Term] id: GO:0060459 name: left lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "left pulmonary development" EXACT [GOC:dph] is_a: GO:0030324 ! lung development [Term] id: GO:0060460 name: left lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph] is_a: GO:0060425 ! lung morphogenesis relationship: part_of GO:0060459 ! left lung development [Term] id: GO:0060461 name: right lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung] is_a: GO:0060425 ! lung morphogenesis relationship: part_of GO:0060458 ! right lung development [Term] id: GO:0060462 name: lung lobe development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060463 name: lung lobe morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060462 ! lung lobe development [Term] id: GO:0060464 name: lung lobe formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060463 ! lung lobe morphogenesis [Term] id: GO:0060465 name: pharynx development namespace: biological_process def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk] synonym: "pharyngeal development" RELATED [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0060466 name: activation of meiosis involved in egg activation namespace: biological_process def: "Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation." [GOC:dph] synonym: "reactivation of meiosis after fertilization" NARROW [GOC:dph] synonym: "resumption of meiosis involved in egg activation" EXACT [GOC:dph] is_a: GO:0045836 ! positive regulation of meiosis relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060467 name: negative regulation of fertilization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph] is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0009566 ! fertilization [Term] id: GO:0060468 name: prevention of polyspermy namespace: biological_process def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph] synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph] synonym: "polyspermy block" EXACT [GOC:dph] is_a: GO:0060467 ! negative regulation of fertilization relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060469 name: positive regulation of transcription involved in egg activation namespace: biological_process def: "Any process that increases the rate, frequency or extent of transcription as a part of the process of egg activation." [GOC:dph] synonym: "activation of the egg genome" RELATED [GOC:dph] synonym: "activation of the maternal genome" RELATED [GOC:dph] is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060470 name: elevation of cytosolic calcium ion concentration involved in egg activation namespace: biological_process def: "The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg." [GOC:dph] is_a: GO:0007204 ! elevation of cytosolic calcium ion concentration is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060471 name: cortical granule exocytosis namespace: biological_process def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy." [GOC:dph] synonym: "cortical granule release" RELATED [GOC:dph] is_a: GO:0017156 ! calcium ion-dependent exocytosis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0060468 ! prevention of polyspermy [Term] id: GO:0060472 name: positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol." [GOC:dph] is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis is_a: GO:0050865 ! regulation of cell activation is_a: GO:0060470 ! elevation of cytosolic calcium ion concentration involved in egg activation is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0060471 ! cortical granule exocytosis [Term] id: GO:0060473 name: cortical granule namespace: cellular_component def: "A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy." [GOC:dph] synonym: "cortical vesicle" RELATED [GOC:dph] is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0060474 name: positive regulation of sperm motility involved in capacitation namespace: biological_process def: "The process in which the controlled movement of a sperm cell is initiated as part of the process required for sperm to reach fertilization competence." [GOC:dph] is_a: GO:2000147 ! positive regulation of cell motility relationship: part_of GO:0048240 ! sperm capacitation relationship: positively_regulates GO:0030317 ! sperm motility [Term] id: GO:0060475 name: positive regulation of actin filament polymerization involved in acrosome reaction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin polymerization as part of the acrosome reaction." [GOC:dph] synonym: "positive regulation of actin polymerization involved in acrosome reaction" RELATED [GOC:dph] is_a: GO:0030838 ! positive regulation of actin filament polymerization relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0060476 name: protein localization involved in acrosome reaction namespace: biological_process def: "The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction." [GOC:dph] synonym: "protein localisation involved in acrosome reaction" EXACT [GOC:mah] is_a: GO:0008105 ! asymmetric protein localization is_a: GO:0030029 ! actin filament-based process is_a: GO:0034613 ! cellular protein localization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0060477 name: peptidyl-serine phosphorylation involved in acrosome reaction namespace: biological_process def: "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine that is part of the acrosome reaction." [GOC:dph] is_a: GO:0018105 ! peptidyl-serine phosphorylation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0060478 name: acrosomal vesicle exocytosis namespace: biological_process def: "The release of intracellular molecules contained within the acrosomal granule by fusion of the vesicle with the plasma membrane of the oocyte, requiring calcium ions." [GOC:dph] synonym: "acrosomal granule exocytosis" RELATED [GOC:dph] synonym: "acrosome exocytosis" EXACT [GOC:dph] is_a: GO:0017156 ! calcium ion-dependent exocytosis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0060479 name: lung cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060480 name: lung goblet cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary goblet cell differentiation" EXACT [] is_a: GO:0060487 ! lung epithelial cell differentiation relationship: part_of GO:0060481 ! lobar bronchus epithelium development [Term] id: GO:0060481 name: lobar bronchus epithelium development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus." [GOC:dph, GOC:mtg_lung] is_a: GO:0060428 ! lung epithelium development relationship: part_of GO:0060482 ! lobar bronchus development [Term] id: GO:0060482 name: lobar bronchus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi." [GOC:dph, GOC:mtg_lung] is_a: GO:0060433 ! bronchus development [Term] id: GO:0060483 name: lobar bronchus mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus." [GOC:dph, GOC:mtg_lung] is_a: GO:0060484 ! lung-associated mesenchyme development relationship: part_of GO:0060482 ! lobar bronchus development [Term] id: GO:0060484 name: lung-associated mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung." [GOC:dph, GOC:mtg_lung] synonym: "lung mesenchyme development" EXACT [GOC:dph] synonym: "pulmonary mesenchyme development" EXACT [GOC:dph] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060485 name: mesenchyme development namespace: biological_process def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph] synonym: "mesenchymal development" EXACT [GOC:dph] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0060486 name: Clara cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Clara cell. A Clara cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles." [GOC:dph, GOC:mtg_lung] is_a: GO:0060487 ! lung epithelial cell differentiation [Term] id: GO:0060487 name: lung epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph] synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060479 ! lung cell differentiation relationship: part_of GO:0060428 ! lung epithelium development [Term] id: GO:0060488 name: orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis namespace: biological_process def: "The process in which a lung bud bifurcates perpendicular to the plane of the previous bud." [GOC:dph, GOC:mtg_lung] synonym: "perpendicular dichotomous subdivision of terminal units involved in lung branching morphogenesis" EXACT [GOC:dph] is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching [Term] id: GO:0060489 name: planar dichotomous subdivision of terminal units involved in lung branching morphogenesis namespace: biological_process def: "The process in which a lung bud bifurcates parallel to the plane of the previous bud." [GOC:dph, GOC:mtg_lung] is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching [Term] id: GO:0060490 name: lateral sprouting involved in lung morphogenesis namespace: biological_process def: "The process in which a branch forms along the side of the lung epithelial tube." [GOC:dph, GOC:mtg_lung] is_a: GO:0060601 ! lateral sprouting from an epithelium relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060491 name: regulation of cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb] synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0044087 ! regulation of cellular component biogenesis relationship: regulates GO:0030031 ! cell projection assembly [Term] id: GO:0060492 name: lung induction namespace: biological_process def: "The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung." [GOC:dph] is_a: GO:0001759 ! organ induction is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis relationship: positively_regulates GO:0060424 ! lung field specification [Term] id: GO:0060493 name: mesenchymal-endodermal cell signaling involved in lung induction namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell in the foregut and contributes to the formation of the lung bud." [GOC:dph, GOC:mtg_lung] synonym: "mesenchymal-endodermal cell signalling involved in lung induction" EXACT [GOC:mah] is_a: GO:0060494 ! inductive mesenchymal-endodermal cell signaling is_a: GO:0060496 ! mesenchymal-epithelial cell signaling involved in lung development is_a: GO:0060497 ! mesenchymal-endodermal cell signaling relationship: part_of GO:0060492 ! lung induction [Term] id: GO:0060494 name: inductive mesenchymal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell changing the fate of the endodermal cell." [GOC:dph, GOC:mtg_lung] synonym: "inductive mesenchymal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0060495 name: cell-cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung] synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060496 name: mesenchymal-epithelial cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung] synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060638 ! mesenchymal-epithelial cell signaling [Term] id: GO:0060497 name: mesenchymal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph] synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0060638 ! mesenchymal-epithelial cell signaling [Term] id: GO:0060498 name: retinoic acid receptor signaling pathway involved in lung bud formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands contributing to the formation of the primary lung bud." [GOC:dph, GOC:mtg_lung] synonym: "retinoic acid receptor signalling pathway involved in lung bud formation" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway relationship: part_of GO:0060431 ! primary lung bud formation [Term] id: GO:0060499 name: fibroblast growth factor receptor signaling pathway involved in lung induction namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands resulting in the formation of the lung bud along the lateral-esophageal sulcus." [GOC:dph, GOC:mtg_lung] synonym: "fibroblast growth factor receptor signalling pathway involved in lung induction" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0031131 ! reception of an inductive signal relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction [Term] id: GO:0060500 name: regulation of transcription from RNA polymerase II promoter involved in lung bud formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the initial primordium of the lung is formed." [GOC:dph, GOC:mtg_lung] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0060431 ! primary lung bud formation [Term] id: GO:0060501 name: positive regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:2000027 ! regulation of organ morphogenesis relationship: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis [Term] id: GO:0060502 name: epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph] is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060428 ! lung epithelium development [Term] id: GO:0060503 name: bud dilation involved in lung branching namespace: biological_process def: "The process in which a bud in the lung increases radially." [GOC:dph] synonym: "bud expansion" EXACT [GOC:dph] is_a: GO:0003401 ! axis elongation relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060504 name: positive regulation of epithelial cell proliferation involved in lung bud dilation namespace: biological_process def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially." [GOC:dph] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0060501 ! positive regulation of epithelial cell proliferation involved in lung morphogenesis is_a: GO:0061047 ! positive regulation of branching involved in lung morphogenesis relationship: positively_regulates GO:0060505 ! epithelial cell proliferation involved in lung bud dilation [Term] id: GO:0060505 name: epithelial cell proliferation involved in lung bud dilation namespace: biological_process def: "The multiplication or reproduction of epithelial cells that contribute to the radial growth of a lung bud." [GOC:dph] is_a: GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis relationship: part_of GO:0060503 ! bud dilation involved in lung branching [Term] id: GO:0060506 name: smoothened signaling pathway involved in lung development namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development." [GOC:dph, GOC:mtg_lung] synonym: "hedgehog signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in lung development" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development [Term] id: GO:0060507 name: epidermal growth factor receptor signaling pathway involved in lung development namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor-type receptor binding to one of its physiological ligands. This process contributes to lung development." [GOC:dph, GOC:mtg_lung] synonym: "epidermal growth factor receptor signalling pathway involved in lung development" EXACT [GOC:mah] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development [Term] id: GO:0060508 name: lung basal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary basal cell differentiation" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060479 ! lung cell differentiation relationship: part_of GO:0060481 ! lobar bronchus epithelium development [Term] id: GO:0060509 name: Type I pneumocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles." [GOC:dph, GOC:mtg_lung, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "membranous pneumocyte differentiation" EXACT [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "small alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "squamous alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0060487 ! lung epithelial cell differentiation [Term] id: GO:0060510 name: Type II pneumocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Type II pneumocyte. A Type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies." [GOC:dph, GOC:mtg_lung, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "granular pneumocyte differentiation" RELATED [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "great alveolar cell differentiation" EXACT [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "large alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0060487 ! lung epithelial cell differentiation [Term] id: GO:0060511 name: creation of an inductive signal by a mesenchymal cell involved in lung induction namespace: biological_process def: "The process in which splanchnic mesenchymal cells send a signal over a short range to endodermal cells inducing them to form the primary lung bud." [GOC:dph, GOC:mtg_lung] is_a: GO:0031130 ! creation of an inductive signal relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction [Term] id: GO:0060512 name: prostate gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a prostate gland are generated and organized." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! organ morphogenesis is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060513 name: prostatic bud formation namespace: biological_process def: "The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph, PMID:18977204] synonym: "primary prostate bud formation" EXACT [GOC:dph] synonym: "prostate ductal budding" EXACT [GOC:dph, PMID:11401393] synonym: "prostate gland formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048645 ! organ formation is_a: GO:0060572 ! morphogenesis of an epithelial bud is_a: GO:0060601 ! lateral sprouting from an epithelium is_a: GO:0060740 ! prostate gland epithelium morphogenesis [Term] id: GO:0060514 name: prostate induction namespace: biological_process def: "The close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, PMID:18977204] is_a: GO:0001759 ! organ induction is_a: GO:0060685 ! regulation of prostatic bud formation is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0060515 ! prostate field specification [Term] id: GO:0060515 name: prostate field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010092 ! specification of organ identity relationship: part_of GO:0060513 ! prostatic bud formation [Term] id: GO:0060516 name: primary prostatic bud elongation namespace: biological_process def: "The increase in size of the prostatic bud as it forms." [GOC:dph, PMID:18977204] synonym: "prostate bud elongation" BROAD [GOC:dph] synonym: "prostate bud elongation involved in prostate morphogenesis" EXACT [GOC:dph] is_a: GO:0060602 ! branch elongation of an epithelium is_a: GO:0060737 ! prostate gland morphogenetic growth is_a: GO:0060740 ! prostate gland epithelium morphogenesis [Term] id: GO:0060517 name: epithelial cell proliferation involved in prostatic bud elongation namespace: biological_process def: "The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud." [GOC:dph, PMID:18977204] is_a: GO:0060767 ! epithelial cell proliferation involved in prostate gland development relationship: part_of GO:0060516 ! primary prostatic bud elongation [Term] id: GO:0060518 name: cell migration involved in prostatic bud elongation namespace: biological_process def: "The orderly movement of epithelial cells from one site to another contributing to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204] is_a: GO:0010631 ! epithelial cell migration is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0060516 ! primary prostatic bud elongation [Term] id: GO:0060519 name: cell adhesion involved in prostatic bud elongation namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204] is_a: GO:0007155 ! cell adhesion is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0060516 ! primary prostatic bud elongation [Term] id: GO:0060520 name: activation of prostate induction by androgen receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, GOC:tb, PMID:18977204] synonym: "activation of prostate induction by androgen receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0030521 ! androgen receptor signaling pathway is_a: GO:0042659 ! regulation of cell fate specification relationship: positively_regulates GO:0060514 ! prostate induction [Term] id: GO:0060521 name: mesenchymal-epithelial cell signaling involved in prostate induction namespace: biological_process def: "Signaling at short range from urogenital sinus mesenchymal cells to cells of the urogenital epithelium resulting in the epithelial cells adopting a prostatic fate." [GOC:dph, PMID:18977204] synonym: "mesenchymal-epithelial cell signalling involved in prostate induction" EXACT [GOC:mah] is_a: GO:0060522 ! inductive mesenchymal to epithelial cell signaling is_a: GO:0060739 ! mesenchymal-epithelial cell signaling involved in prostate gland development relationship: part_of GO:0060514 ! prostate induction [Term] id: GO:0060522 name: inductive mesenchymal to epithelial cell signaling namespace: biological_process def: "Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells." [GOC:dph] synonym: "inductive mesenchymal to epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0060523 name: prostate epithelial cord elongation namespace: biological_process def: "The developmental growth process in which solid chords of prostate epithelium increase in length." [GOC:dph, PMID:18977204] is_a: GO:0060602 ! branch elongation of an epithelium is_a: GO:0060737 ! prostate gland morphogenetic growth is_a: GO:0060740 ! prostate gland epithelium morphogenesis relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis [Term] id: GO:0060524 name: dichotomous subdivision of prostate epithelial cord terminal unit namespace: biological_process def: "The process in which a prostate epithelial cord bifurcates at its end." [GOC:dph, PMID:18977204] synonym: "prostate epithelial cord bifurcation" EXACT [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis [Term] id: GO:0060525 name: prostate glandular acinus development namespace: biological_process def: "The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060526 name: prostate glandular acinus morphogenesis namespace: biological_process def: "The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland." [GOC:dph] is_a: GO:0060740 ! prostate gland epithelium morphogenesis relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060527 name: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis namespace: biological_process def: "The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini." [GOC:dph, PMID:18977204] is_a: GO:0060442 ! branching involved in prostate gland morphogenesis relationship: part_of GO:0060526 ! prostate glandular acinus morphogenesis [Term] id: GO:0060528 name: secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate." [GOC:dph, PMID:18977204] is_a: GO:0002067 ! glandular epithelial cell differentiation is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060529 name: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate." [GOC:dph, PMID:18977204] is_a: GO:0002067 ! glandular epithelial cell differentiation is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060530 name: smooth muscle cell differentiation involved in prostate glandular acinus development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060531 name: neuroendocrine cell differentiation involved in prostate gland acinus development namespace: biological_process def: "The process in which relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0061101 ! neuroendocrine cell differentiation relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060532 name: bronchus cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cartilage development" EXACT [] is_a: GO:0051216 ! cartilage development relationship: part_of GO:0060433 ! bronchus development [Term] id: GO:0060533 name: bronchus cartilage morphogenesis namespace: biological_process def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis relationship: part_of GO:0060434 ! bronchus morphogenesis relationship: part_of GO:0060532 ! bronchus cartilage development [Term] id: GO:0060534 name: trachea cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051216 ! cartilage development relationship: part_of GO:0060438 ! trachea development [Term] id: GO:0060535 name: trachea cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis relationship: part_of GO:0060439 ! trachea morphogenesis relationship: part_of GO:0060534 ! trachea cartilage development [Term] id: GO:0060536 name: cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0009887 ! organ morphogenesis relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0060537 name: muscle tissue development namespace: biological_process def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph] is_a: GO:0009888 ! tissue development [Term] id: GO:0060538 name: skeletal muscle organ development namespace: biological_process def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph] is_a: GO:0007517 ! muscle organ development [Term] id: GO:0060539 name: diaphragm development namespace: biological_process def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph] is_a: GO:0060538 ! skeletal muscle organ development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0060540 name: diaphragm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph] is_a: GO:0048644 ! muscle organ morphogenesis relationship: part_of GO:0060539 ! diaphragm development [Term] id: GO:0060541 name: respiratory system development namespace: biological_process def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph] is_a: GO:0048731 ! system development [Term] id: GO:0060542 name: regulation of strand invasion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:tb] is_a: GO:0000018 ! regulation of DNA recombination relationship: regulates GO:0042148 ! strand invasion [Term] id: GO:0060543 name: negative regulation of strand invasion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:elh, GOC:tb] synonym: "negative regulation of D-loop biosynthesis" RELATED [GOC:elh] synonym: "negative regulation of D-loop formation" RELATED [GOC:elh] synonym: "negative regulation of Rad51-mediated strand invasion" EXACT [GOC:elh] is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:0060542 ! regulation of strand invasion relationship: negatively_regulates GO:0042148 ! strand invasion [Term] id: GO:0060544 name: regulation of necroptosis namespace: biological_process def: "Any process that modulates the rate frequency or extent of necroptosis. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010939 ! regulation of necrotic cell death relationship: regulates GO:0070266 ! necroptosis [Term] id: GO:0060545 name: positive regulation of necroptosis namespace: biological_process def: "Any process that increases the rate frequency or extent of necroptosis. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010940 ! positive regulation of necrotic cell death is_a: GO:0060544 ! regulation of necroptosis relationship: positively_regulates GO:0070266 ! necroptosis [Term] id: GO:0060546 name: negative regulation of necroptosis namespace: biological_process def: "Any process that decreases the rate frequency or extent of necroptosis. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0060544 ! regulation of necroptosis is_a: GO:0060547 ! negative regulation of necrotic cell death relationship: negatively_regulates GO:0070266 ! necroptosis [Term] id: GO:0060547 name: negative regulation of necrotic cell death namespace: biological_process def: "Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010939 ! regulation of necrotic cell death is_a: GO:0060548 ! negative regulation of cell death relationship: negatively_regulates GO:0070265 ! necrotic cell death [Term] id: GO:0060548 name: negative regulation of cell death namespace: biological_process def: "Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010941 ! regulation of cell death is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0008219 ! cell death [Term] id: GO:0060549 name: regulation of fructose 1,6-bisphosphate 1-phosphatase activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity [Term] id: GO:0060550 name: positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0060549 ! regulation of fructose 1,6-bisphosphate 1-phosphatase activity [Term] id: GO:0060551 name: regulation of fructose 1,6-bisphosphate metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process relationship: regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process [Term] id: GO:0060552 name: positive regulation of fructose 1,6-bisphosphate metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0060551 ! regulation of fructose 1,6-bisphosphate metabolic process relationship: positively_regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process [Term] id: GO:0060553 name: induction of necroptosis namespace: biological_process def: "Any process that starts the inactive process of necroptosis. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb] synonym: "activation of necroptosis" EXACT [GOC:dph, GOC:tb] is_a: GO:0060545 ! positive regulation of necroptosis [Term] id: GO:0060554 name: induction of necroptosis of activated-T cells namespace: biological_process def: "Any process that starts the inactive process of necroptosis in an activated T cell. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0060553 ! induction of necroptosis [Term] id: GO:0060555 name: induction of necroptosis by extracellular signals namespace: biological_process def: "Any process that starts the inactive process of necroptosis as a result of a signal outside the cell. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0060553 ! induction of necroptosis [Term] id: GO:0060556 name: regulation of vitamin D biosynthetic process namespace: biological_process def: "Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process relationship: regulates GO:0042368 ! vitamin D biosynthetic process [Term] id: GO:0060557 name: positive regulation of vitamin D biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046136 ! positive regulation of vitamin metabolic process is_a: GO:0060556 ! regulation of vitamin D biosynthetic process relationship: positively_regulates GO:0042368 ! vitamin D biosynthetic process [Term] id: GO:0060558 name: regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032768 ! regulation of monooxygenase activity [Term] id: GO:0060559 name: positive regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032770 ! positive regulation of monooxygenase activity is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity [Term] id: GO:0060560 name: developmental growth involved in morphogenesis namespace: biological_process def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] synonym: "differential growth" EXACT [GOC:dph] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0060561 name: apoptosis involved in morphogenesis namespace: biological_process def: "The process of apoptosis that contributes to the shaping of an anatomical structure." [GOC:dph] synonym: "morphogenetic apoptosis" RELATED [GOC:dph] is_a: GO:0006915 ! apoptosis is_a: GO:0010623 ! developmental programmed cell death relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0060562 name: epithelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0035239 ! tube morphogenesis [Term] id: GO:0060563 name: neuroepithelial cell differentiation namespace: biological_process def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0060564 name: negative regulation of mitotic anaphase-promoting complex activity namespace: biological_process def: "Any process that decreases the rate frequency or extent of anaphase-promoting complex activity regulating the mitotic cell cycle." [GOC:dph, GOC:tb] synonym: "negative regulation of anaphase-promoting complex activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of APC activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition is_a: GO:0051436 ! negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle relationship: negatively_regulates GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0060565 name: inhibition of mitotic anaphase-promoting complex activity namespace: biological_process def: "Any process that prevents the activation of anaphase-promoting complex activity regulating the mitotic cell cycle." [GOC:dph, GOC:tb] synonym: "inhibition of APC activity during mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "inhibition of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0060564 ! negative regulation of mitotic anaphase-promoting complex activity [Term] id: GO:0060566 name: positive regulation of transcription termination, DNA-dependent namespace: biological_process def: "Any process that increases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0031554 ! regulation of transcription termination, DNA-dependent is_a: GO:0043243 ! positive regulation of protein complex disassembly is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent relationship: positively_regulates GO:0006353 ! transcription termination, DNA-dependent [Term] id: GO:0060567 name: negative regulation of transcription termination, DNA-dependent namespace: biological_process def: "Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0031554 ! regulation of transcription termination, DNA-dependent is_a: GO:0043242 ! negative regulation of protein complex disassembly is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent relationship: negatively_regulates GO:0006353 ! transcription termination, DNA-dependent [Term] id: GO:0060568 name: regulation of peptide hormone processing namespace: biological_process def: "Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage is_a: GO:0032350 ! regulation of hormone metabolic process relationship: regulates GO:0016486 ! peptide hormone processing [Term] id: GO:0060569 name: positive regulation of peptide hormone processing namespace: biological_process def: "Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] is_a: GO:0010954 ! positive regulation of protein maturation by peptide bond cleavage is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0060568 ! regulation of peptide hormone processing relationship: positively_regulates GO:0016486 ! peptide hormone processing [Term] id: GO:0060570 name: negative regulation of peptide hormone processing namespace: biological_process def: "Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] is_a: GO:0010955 ! negative regulation of protein maturation by peptide bond cleavage is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0060568 ! regulation of peptide hormone processing relationship: negatively_regulates GO:0016486 ! peptide hormone processing [Term] id: GO:0060571 name: morphogenesis of an epithelial fold namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph] synonym: "epithelial folding" EXACT [GOC:dph] synonym: "folding of an epithelial sheet" RELATED [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0060572 name: morphogenesis of an epithelial bud namespace: biological_process def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph] is_a: GO:0060571 ! morphogenesis of an epithelial fold [Term] id: GO:0060573 name: cell fate specification involved in pattern specification namespace: biological_process def: "The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:tb] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification [Term] id: GO:0060574 name: intestinal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation relationship: part_of GO:0060576 ! intestinal epithelial cell development [Term] id: GO:0060575 name: intestinal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0060576 name: intestinal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development relationship: part_of GO:0060575 ! intestinal epithelial cell differentiation [Term] id: GO:0060577 name: pulmonary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph] synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis [Term] id: GO:0060578 name: superior vena cava morphogenesis namespace: biological_process def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis [Term] id: GO:0060579 name: ventral spinal cord interneuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning relationship: part_of GO:0021514 ! ventral spinal cord interneuron differentiation [Term] id: GO:0060580 name: ventral spinal cord interneuron fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph] is_a: GO:0048664 ! neuron fate determination relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment [Term] id: GO:0060581 name: cell fate commitment involved in pattern specification namespace: biological_process def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0007389 ! pattern specification process [Term] id: GO:0060582 name: cell fate determination involved in pattern specification namespace: biological_process def: "A process involved in commitment of a cell to a fate in a developmental field. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification [Term] id: GO:0060583 name: regulation of actin cortical patch localization namespace: biological_process def: "Any process that modulates the localization of an actin cortical patch. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:dph, GOC:tb] synonym: "regulation of actin cortical patch localisation" EXACT [GOC:mah] is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0051666 ! actin cortical patch localization [Term] id: GO:0060584 name: regulation of prostaglandin-endoperoxide synthase activity namespace: biological_process def: "Any process that modulates the rate, frequency or prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of (PG)H synthase activity" EXACT [EC:1.14.99.1] synonym: "regulation of fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] synonym: "regulation of PG synthetase activity" EXACT [EC:1.14.99.1] synonym: "regulation of prostaglandin synthetase activity" EXACT [EC:1.14.99.1] is_a: GO:0051341 ! regulation of oxidoreductase activity [Term] id: GO:0060585 name: positive regulation of prostaglandin-endoperoxide synthase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of (PG)H synthase activity" EXACT [EC:1.14.99.1] synonym: "positive regulation of fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] synonym: "positive regulation of PG synthetase activity" EXACT [EC:1.14.99.1] synonym: "positive regulation of prostaglandin synthetase activity" EXACT [EC:1.14.99.1] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:0060584 ! regulation of prostaglandin-endoperoxide synthase activity [Term] id: GO:0060586 name: multicellular organismal iron ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism." [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0048871 ! multicellular organismal homeostasis is_a: GO:0055072 ! iron ion homeostasis [Term] id: GO:0060587 name: regulation of lipoprotein lipid oxidation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0034442 ! regulation of lipoprotein oxidation relationship: regulates GO:0034439 ! lipoprotein lipid oxidation [Term] id: GO:0060588 name: negative regulation of lipoprotein lipid oxidation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0034443 ! negative regulation of lipoprotein oxidation is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0060587 ! regulation of lipoprotein lipid oxidation relationship: negatively_regulates GO:0034439 ! lipoprotein lipid oxidation [Term] id: GO:0060589 name: nucleoside-triphosphatase regulator activity namespace: molecular_function def: "Modulates the rate of NTP hydrolysis by a NTPase." [GOC:dph, GOC:tb] synonym: "NTPase regulator activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0060590 name: ATPase regulator activity namespace: molecular_function def: "Modulates the rate of ATP hydrolysis by an ATPase." [GOC:dph, GOC:tb] is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity [Term] id: GO:0060591 name: chondroblast differentiation namespace: biological_process def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph] synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0060592 name: mammary gland formation namespace: biological_process def: "The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme." [GOC:dph, PMID:16168142, PMID:17120154] synonym: "mammary bud formation" RELATED [GOC:dph] synonym: "mammary line formation" NARROW [GOC:dph] synonym: "mammary placode formation" NARROW [GOC:dph] synonym: "mammary sprout formation" RELATED [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060443 ! mammary gland morphogenesis [Term] id: GO:0060593 name: Wnt receptor signaling pathway involved in mammary gland specification namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142] synonym: "Wnt receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0060594 ! mammary gland specification [Term] id: GO:0060594 name: mammary gland specification namespace: biological_process def: "The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph] synonym: "mammary line specification" RELATED [GOC:dph] is_a: GO:0010092 ! specification of organ identity is_a: GO:0060592 ! mammary gland formation [Term] id: GO:0060595 name: fibroblast growth factor receptor signaling pathway involved in mammary gland specification namespace: biological_process def: "The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142] synonym: "fibroblast growth factor receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0060594 ! mammary gland specification [Term] id: GO:0060596 name: mammary placode formation namespace: biological_process def: "The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper." [GOC:dph, PMID:16168142] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0060592 ! mammary gland formation [Term] id: GO:0060597 name: regulation of transcription from RNA polymerase II promoter involved in mammary gland formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of the mammary line, placode or bud." [GOC:dph, PMID:16168142] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0060592 ! mammary gland formation [Term] id: GO:0060598 name: dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis namespace: biological_process def: "The process in which the terminal end of a mammary duct bifurcates." [GOC:dph, PMID:17120154] synonym: "primary mammary duct branching " EXACT [GOC:dph] is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis [Term] id: GO:0060599 name: lateral sprouting involved in mammary gland duct morphogenesis namespace: biological_process def: "The process in which a branch forms along the side of a mammary duct." [GOC:dph, PMID:17120154] synonym: "mammary gland duct secondary branching" EXACT [GOC:dph] is_a: GO:0060601 ! lateral sprouting from an epithelium relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis [Term] id: GO:0060600 name: dichotomous subdivision of an epithelial terminal unit namespace: biological_process def: "The process in which an epithelial cord, rod or tube bifurcates at its end." [GOC:dph] synonym: "primary branching of an epithelium" RELATED [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium [Term] id: GO:0060601 name: lateral sprouting from an epithelium namespace: biological_process def: "The process in which a branch forms along the side of an epithelium." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium [Term] id: GO:0060602 name: branch elongation of an epithelium namespace: biological_process def: "The growth process in which a branch increases in length from its base to its tip." [GOC:dph] is_a: GO:0003401 ! axis elongation relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium [Term] id: GO:0060603 name: mammary gland duct morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk." [GOC:dph, PMID:17120154] is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0060443 ! mammary gland morphogenesis relationship: part_of GO:0061180 ! mammary gland epithelium development [Term] id: GO:0060604 name: mammary gland duct cavitation namespace: biological_process def: "Creation of the central hole of the mammary gland duct by the hollowing out of a solid rod." [GOC:dph, PMID:17120154] synonym: "milk duct cavitation" RELATED [GOC:dph] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0060603 ! mammary gland duct morphogenesis [Term] id: GO:0060605 name: tube lumen cavitation namespace: biological_process def: "The formation of a lumen by hollowing out a solid rod or cord." [GOC:dph] is_a: GO:0035148 ! tube formation [Term] id: GO:0060606 name: tube closure namespace: biological_process def: "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold." [GOC:dph] is_a: GO:0035148 ! tube formation [Term] id: GO:0060607 name: cell-cell adhesion involved in sealing an epithelial fold namespace: biological_process def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of an epithelial tube." [GOC:dph] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0060606 ! tube closure [Term] id: GO:0060608 name: cell-cell adhesion involved in neural tube closure namespace: biological_process def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of the neural tube." [GOC:dph] is_a: GO:0060607 ! cell-cell adhesion involved in sealing an epithelial fold relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0060609 name: apoptosis involved in tube lumen cavitation namespace: biological_process def: "The process of apoptosis that contributes to the hollowing out of an epithelial rod or cord to form the central hole in a tube." [GOC:dph] is_a: GO:0060561 ! apoptosis involved in morphogenesis relationship: part_of GO:0060605 ! tube lumen cavitation [Term] id: GO:0060610 name: mesenchymal cell differentiation involved in mammary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mammary gland mesenchymal cell. Mammary gland mesenchymal cells form a loosely connected network of cells that surround the mammary ducts." [GOC:dph] synonym: "mammary gland mesenchymal cell differentiation" EXACT [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0060611 name: mammary gland fat development namespace: biological_process def: "The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." [GOC:dph] is_a: GO:0060612 ! adipose tissue development relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0060612 name: adipose tissue development namespace: biological_process def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph] synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0060613 name: fat pad development namespace: biological_process def: "The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue." [GOC:dph] is_a: GO:0060612 ! adipose tissue development [Term] id: GO:0060614 name: negative regulation of mammary gland development in males by androgen receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell." [GOC:dph] synonym: "negative regulation of mammary gland development in males by androgen receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0030521 ! androgen receptor signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000026 ! regulation of multicellular organismal development relationship: negatively_regulates GO:0030879 ! mammary gland development [Term] id: GO:0060615 name: mammary gland bud formation namespace: biological_process def: "The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis." [GOC:dph, PMID:12558599] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060648 ! mammary gland bud morphogenesis [Term] id: GO:0060616 name: mammary gland cord formation namespace: biological_process def: "The process in which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad." [GOC:dph, PMID:12558599] synonym: "mammary gland sprout formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0060652 ! mammary gland cord morphogenesis [Term] id: GO:0060617 name: positive regulation of mammary placode formation by mesenchymal-epithelial signaling namespace: biological_process def: "Any process that initiates the formation of a mammary placode through a mechanism that mediates the transfer of information from a mesenchymal cell to an epithelial cell resulting in the epithelial cell adopting the identity of a cell of the mammary placode." [GOC:dph, PMID:12558599] synonym: "positive regulation of mammary placode formation by mesenchymal-epithelial signalling" EXACT [GOC:mah] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060638 ! mesenchymal-epithelial cell signaling is_a: GO:2000026 ! regulation of multicellular organismal development relationship: positively_regulates GO:0060596 ! mammary placode formation [Term] id: GO:0060618 name: nipple development namespace: biological_process def: "The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0060619 name: cell migration involved in mammary placode formation namespace: biological_process def: "The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode." [GOC:dph, PMID:12558599] is_a: GO:0010631 ! epithelial cell migration relationship: part_of GO:0060596 ! mammary placode formation [Term] id: GO:0060620 name: regulation of cholesterol import namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032374 ! regulation of cholesterol transport is_a: GO:0034762 ! regulation of transmembrane transport relationship: regulates GO:0070508 ! cholesterol import [Term] id: GO:0060621 name: negative regulation of cholesterol import namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0060620 ! regulation of cholesterol import relationship: negatively_regulates GO:0070508 ! cholesterol import [Term] id: GO:0060622 name: regulation of ascospore wall beta-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of ascospore wall beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb] is_a: GO:0034307 ! regulation of ascospore formation is_a: GO:0090093 ! regulation of fungal-type cell wall beta-glucan biosynthetic process relationship: regulates GO:0034412 ! ascospore wall beta-glucan biosynthetic process [Term] id: GO:0060623 name: regulation of chromosome condensation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization relationship: regulates GO:0030261 ! chromosome condensation [Term] id: GO:0060624 name: regulation of ascospore wall 1,3-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of ascospore wall 1,3-beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb] synonym: "regulation of ascospore wall 1,3-beta-glucan biosynthetic process" BROAD [] is_a: GO:0060622 ! regulation of ascospore wall beta-glucan biosynthetic process is_a: GO:0090334 ! regulation of cell wall 1,3-beta-D-glucan biosynthetic process relationship: regulates GO:0034413 ! ascospore wall 1,3-beta-D-glucan biosynthetic process [Term] id: GO:0060625 name: regulation of protein deneddylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:dph, GOC:tb] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0000338 ! protein deneddylation [Term] id: GO:0060626 name: regulation of cullin deneddylation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cullin deneddylation, the modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1)." [GOC:dph, GOC:tb] is_a: GO:0060625 ! regulation of protein deneddylation relationship: regulates GO:0010388 ! cullin deneddylation [Term] id: GO:0060627 name: regulation of vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0016192 ! vesicle-mediated transport [Term] id: GO:0060628 name: regulation of ER to Golgi vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:dph, GOC:tb] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0006888 ! ER to Golgi vesicle-mediated transport [Term] id: GO:0060629 name: regulation of homologous chromosome segregation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of homologous chromosome segregation, the cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:dph, GOC:tb] is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0060631 ! regulation of meiosis I relationship: regulates GO:0045143 ! homologous chromosome segregation [Term] id: GO:0060630 name: regulation of M/G1 transition of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of M/G1 transition of the mitotic cell cycle, the progression from M phase to G1 phase of the mitotic cell cycle." [GOC:dph, GOC:tb] is_a: GO:2000602 ! regulation of interphase of mitotic cell cycle relationship: regulates GO:0000216 ! M/G1 transition of mitotic cell cycle [Term] id: GO:0060631 name: regulation of meiosis I namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb] is_a: GO:0040020 ! regulation of meiosis relationship: regulates GO:0007127 ! meiosis I [Term] id: GO:0060632 name: regulation of microtubule-based movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process relationship: regulates GO:0007018 ! microtubule-based movement [Term] id: GO:0060633 name: negative regulation of transcription initiation from RNA polymerase II promoter namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb] is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter is_a: GO:2000143 ! negative regulation of transcription initiation, DNA-dependent relationship: negatively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0060634 name: regulation of 4,6-pyruvylated galactose residue biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process [Term] id: GO:0060635 name: positive regulation of 1,3-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta-1,3 glucans." [GOC:dph, GOC:tb] synonym: "positive regulation of 1,3-beta-glucan biosynthetic process" BROAD [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032953 ! regulation of 1,3-beta-D-glucan biosynthetic process relationship: positively_regulates GO:0006075 ! 1,3-beta-D-glucan biosynthetic process [Term] id: GO:0060636 name: negative regulation of 1,3-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta-1,3 glucans." [GOC:dph, GOC:tb] synonym: "negative regulation of 1,3-beta-glucan biosynthetic process" BROAD [] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0032953 ! regulation of 1,3-beta-D-glucan biosynthetic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0006075 ! 1,3-beta-D-glucan biosynthetic process [Term] id: GO:0060637 name: positive regulation of lactation by mesenchymal-epithelial cell signaling namespace: biological_process def: "The process that increases the rate, frequency, or extent of lactation as a result of the secretion of a signal from the mammary fat and its reception by a mammary epithelial cell." [GOC:dph, PMID:12558599] synonym: "positive regulation of lactation by mesenchymal-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060638 ! mesenchymal-epithelial cell signaling is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0007595 ! lactation [Term] id: GO:0060638 name: mesenchymal-epithelial cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph] synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0060639 name: positive regulation of salivary gland formation by mesenchymal-epithelial signaling namespace: biological_process def: "Any process that induces the formation of the salivary gland field by means of the secretion of a signal by a mesenchymal cell and its reception and interpretation by an epithelial cell resulting in it adopting the identity of a salivary gland bud cell." [GOC:dph] synonym: "positive regulation of salivary gland formation by mesenchymal-epithelial signalling" EXACT [GOC:mah] is_a: GO:0060638 ! mesenchymal-epithelial cell signaling relationship: positively_regulates GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0060640 name: positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signaling namespace: biological_process def: "Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud." [GOC:dph] synonym: "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signalling" EXACT [GOC:mah] is_a: GO:0042488 ! positive regulation of odontogenesis of dentine-containing tooth is_a: GO:0060638 ! mesenchymal-epithelial cell signaling [Term] id: GO:0060641 name: mammary gland duct regression in males namespace: biological_process def: "The process in which the epithelium of the mammary duct is destroyed in males." [GOC:dph, PMID:12558599] is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0060603 ! mammary gland duct morphogenesis [Term] id: GO:0060642 name: white fat cell differentiation involved in mammary gland fat development namespace: biological_process def: "The process in which a preadipocyte acquires specialized features of a white adipocyte of the mammary gland. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [GOC:dph, PMID:12558599] is_a: GO:0050872 ! white fat cell differentiation relationship: part_of GO:0060611 ! mammary gland fat development [Term] id: GO:0060643 name: epithelial cell differentiation involved in mammary gland bud morphogenesis namespace: biological_process def: "The process in which a cell of the mammary placode becomes a cell of the mammary gland bud." [GOC:dph] is_a: GO:0060644 ! mammary gland epithelial cell differentiation relationship: part_of GO:0060615 ! mammary gland bud formation [Term] id: GO:0060644 name: mammary gland epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0061180 ! mammary gland epithelium development [Term] id: GO:0060645 name: peripheral mammary gland bud epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an epithelial cell at the periphery of the mammary gland bud. Cells at the periphery of the bud are larger that those of the surrounding epithelium and are arranged concentrically." [GOC:dph, PMID:12558599] is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis [Term] id: GO:0060646 name: internal mammary gland bud epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape." [GOC:dph, PMID:12558599] is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis [Term] id: GO:0060647 name: mesenchymal cell condensation involved in mammary fat development namespace: biological_process def: "The cell adhesion process in which mammary mesenchyme cells adhere to one another in the initial stages of the formation of mammary fat development." [GOC:dph, PMID:12558599] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0060611 ! mammary gland fat development [Term] id: GO:0060648 name: mammary gland bud morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord." [GOC:dph, PMID:12558599] is_a: GO:0060572 ! morphogenesis of an epithelial bud relationship: part_of GO:0060603 ! mammary gland duct morphogenesis [Term] id: GO:0060649 name: mammary gland bud elongation namespace: biological_process def: "The process in which the mammary gland bud grows along its axis." [GOC:dph, PMID:12558599] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060648 ! mammary gland bud morphogenesis [Term] id: GO:0060650 name: epithelial cell proliferation involved in mammary gland bud elongation namespace: biological_process def: "The multiplication or reproduction of mammary gland bud epithelial cells, resulting in the elongation of the bud." [GOC:dph, PMID:12558599] is_a: GO:0033598 ! mammary gland epithelial cell proliferation relationship: part_of GO:0060649 ! mammary gland bud elongation [Term] id: GO:0060651 name: regulation of epithelial cell proliferation involved in mammary gland bud elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mammary gland bud epithelial cell proliferation that results in the elongation of the bud." [GOC:dph, PMID:12558599] is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0060650 ! epithelial cell proliferation involved in mammary gland bud elongation [Term] id: GO:0060652 name: mammary gland cord morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat." [GOC:dph, PMID:12558599] synonym: "mammary gland sprout morphogenesis" EXACT [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0060603 ! mammary gland duct morphogenesis [Term] id: GO:0060653 name: epithelial cell differentiation involved in mammary gland cord morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified." [GOC:dph, PMID:12558599] synonym: "epithelial cell differentiation involved in mammary gland sprout morphogenesis" RELATED [GOC:dph] is_a: GO:0060644 ! mammary gland epithelial cell differentiation relationship: part_of GO:0060652 ! mammary gland cord morphogenesis [Term] id: GO:0060654 name: mammary gland cord elongation namespace: biological_process def: "The process in which the mammary gland sprout grows along its axis." [GOC:dph, PMID:12558599] is_a: GO:0060602 ! branch elongation of an epithelium relationship: part_of GO:0060652 ! mammary gland cord morphogenesis [Term] id: GO:0060655 name: branching involved in mammary gland cord morphogenesis namespace: biological_process def: "The process in which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct." [GOC:dph, PMID:12558599] is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis relationship: part_of GO:0060652 ! mammary gland cord morphogenesis [Term] id: GO:0060656 name: regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching of the mammary gland cord as a result of a signal being created by a mammary fat precursor cell and its subsequent reception and interpretation by a mammary cord epithelial cell." [GOC:dph, PMID:12558599] synonym: "regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0060762 ! regulation of branching involved in mammary gland duct morphogenesis relationship: regulates GO:0060655 ! branching involved in mammary gland cord morphogenesis [Term] id: GO:0060657 name: regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell." [GOC:dph, PMID:12558599] synonym: "regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: regulates GO:0060654 ! mammary gland cord elongation [Term] id: GO:0060658 name: nipple morphogenesis namespace: biological_process def: "The process in which the nipple is generated and organized." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060618 ! nipple development [Term] id: GO:0060659 name: nipple sheath formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis. This process begins with a circular ingrowth of the epidermis around the region of the mammary sprout. It ends before the region begins to elevate." [GOC:dph, PMID:12558599] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060658 ! nipple morphogenesis [Term] id: GO:0060660 name: epidermis morphogenesis involved in nipple formation namespace: biological_process def: "The process in which the epidermis of the nipple sheath is uplifted to form an umbrella-like projection." [GOC:dph, PMID:12558599] is_a: GO:0048730 ! epidermis morphogenesis relationship: part_of GO:0060658 ! nipple morphogenesis [Term] id: GO:0060661 name: submandibular salivary gland formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed." [GOC:dph, PMID:17336109] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0060662 name: salivary gland cavitation namespace: biological_process def: "The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland." [GOC:dph] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0060663 name: apoptosis involved in salivary gland cavitation namespace: biological_process def: "The apoptosis process in which the solid core of the gland is hollowed out to form the duct." [GOC:dph, PMID:17336109] is_a: GO:0060609 ! apoptosis involved in tube lumen cavitation relationship: part_of GO:0060662 ! salivary gland cavitation [Term] id: GO:0060664 name: epithelial cell proliferation involved in salivary gland morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland." [GOC:dph, PMID:17336109] is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0060665 name: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium." [GOC:dph, PMID:17336109] synonym: "regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalling" EXACT [GOC:mah] is_a: GO:0060638 ! mesenchymal-epithelial cell signaling is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis [Term] id: GO:0060666 name: dichotomous subdivision of terminal units involved in salivary gland branching namespace: biological_process def: "The process in which a salivary epithelial cord bifurcates at its end." [GOC:dph] is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis [Term] id: GO:0060667 name: branch elongation involved in salivary gland morphogenesis namespace: biological_process def: "The differential growth of the salivary branches along their axis, resulting in the growth of a branch." [GOC:dph] is_a: GO:0060602 ! branch elongation of an epithelium relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis [Term] id: GO:0060668 name: regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland." [GOC:dph] synonym: "regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0035426 ! extracellular matrix-cell signaling is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis [Term] id: GO:0060669 name: embryonic placenta morphogenesis namespace: biological_process def: "The process in which the embryonic placenta is generated and organized." [GOC:dph] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001892 ! embryonic placenta development [Term] id: GO:0060670 name: branching involved in embryonic placenta morphogenesis namespace: biological_process def: "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer." [GOC:dph, PMID:16916377] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0060669 ! embryonic placenta morphogenesis relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis [Term] id: GO:0060671 name: epithelial cell differentiation involved in embryonic placenta development namespace: biological_process def: "The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer." [GOC:dph, PMID:16916377] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development relationship: part_of GO:0060711 ! labyrinthine layer development [Term] id: GO:0060672 name: epithelial cell morphogenesis involved in placental branching namespace: biological_process def: "The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:16916377] is_a: GO:0003382 ! epithelial cell morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060670 ! branching involved in embryonic placenta morphogenesis relationship: part_of GO:0060671 ! epithelial cell differentiation involved in embryonic placenta development [Term] id: GO:0060673 name: cell-cell signaling involved in placenta development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another." [GOC:dph, PMID:16916377] synonym: "cell-cell signalling involved in placenta development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0001892 ! embryonic placenta development [Term] id: GO:0060674 name: placenta blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure." [GOC:dph, PMID:16916377] is_a: GO:0001568 ! blood vessel development relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0060675 name: ureteric bud morphogenesis namespace: biological_process def: "The process in which the ureteric bud is generated and organized." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0001657 ! ureteric bud development [Term] id: GO:0060676 name: ureteric bud formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud." [GOC:dph, PMID:16916378] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0060675 ! ureteric bud morphogenesis [Term] id: GO:0060677 name: ureteric bud elongation namespace: biological_process def: "The process in which the ureteric bud grows along its axis." [GOC:dph, PMID:16916378] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060675 ! ureteric bud morphogenesis [Term] id: GO:0060678 name: dichotomous subdivision of terminal units involved in ureteric bud branching namespace: biological_process def: "The process in which a ureteric bud bifurcates at its end." [GOC:dph, PMID:16916378] synonym: "bifid subdivision of terminal units involved in ureteric bud branching" EXACT [GOC:dph, PMID:16916378] is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis [Term] id: GO:0060679 name: trifid subdivision of terminal units involved in ureteric bud branching namespace: biological_process def: "The process in which a ureteric bud splits into three units at its end." [GOC:dph, PMID:16916378] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis [Term] id: GO:0060680 name: lateral sprouting involved in ureteric bud morphogenesis namespace: biological_process def: "The process in which a branch forms along the side of a ureteric bud." [GOC:dph, PMID:16916378] is_a: GO:0060601 ! lateral sprouting from an epithelium relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis [Term] id: GO:0060681 name: branch elongation involved in ureteric bud branching namespace: biological_process def: "The growth of a branch of the ureteric bud along its axis." [GOC:dph, PMID:16916378] is_a: GO:0060602 ! branch elongation of an epithelium is_a: GO:0060677 ! ureteric bud elongation relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis [Term] id: GO:0060682 name: primary ureteric bud growth namespace: biological_process def: "The process in which the primary ureteric bud grows along its axis dorsally toward the metanephric blastema." [GOC:dph, PMID:16916378] is_a: GO:0060677 ! ureteric bud elongation [Term] id: GO:0060683 name: regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland." [GOC:dph, PMID:18559345] synonym: "regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalling" EXACT [GOC:mah] is_a: GO:0060684 ! epithelial-mesenchymal cell signaling is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis [Term] id: GO:0060684 name: epithelial-mesenchymal cell signaling namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0060685 name: regulation of prostatic bud formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph] is_a: GO:0003156 ! regulation of organ formation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0060513 ! prostatic bud formation [Term] id: GO:0060686 name: negative regulation of prostatic bud formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0060685 ! regulation of prostatic bud formation is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0060513 ! prostatic bud formation [Term] id: GO:0060687 name: regulation of branching involved in prostate gland morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:2000027 ! regulation of organ morphogenesis is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0060442 ! branching involved in prostate gland morphogenesis [Term] id: GO:0060688 name: regulation of morphogenesis of a branching structure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0001763 ! morphogenesis of a branching structure [Term] id: GO:0060689 name: cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland." [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007431 ! salivary gland development [Term] id: GO:0060690 name: epithelial cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060689 ! cell differentiation involved in salivary gland development [Term] id: GO:0060691 name: epithelial cell maturation involved in salivary gland development namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation relationship: part_of GO:0060690 ! epithelial cell differentiation involved in salivary gland development [Term] id: GO:0060692 name: mesenchymal cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the salivary gland. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation is_a: GO:0060689 ! cell differentiation involved in salivary gland development [Term] id: GO:0060693 name: regulation of branching involved in salivary gland morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0060445 ! branching involved in salivary gland morphogenesis [Term] id: GO:0060694 name: regulation of cholesterol transporter activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032374 ! regulation of cholesterol transport is_a: GO:0032409 ! regulation of transporter activity [Term] id: GO:0060695 name: negative regulation of cholesterol transporter activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0060694 ! regulation of cholesterol transporter activity [Term] id: GO:0060696 name: regulation of phospholipid catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0050994 ! regulation of lipid catabolic process relationship: regulates GO:0009395 ! phospholipid catabolic process [Term] id: GO:0060697 name: positive regulation of phospholipid catabolic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:0060696 ! regulation of phospholipid catabolic process relationship: positively_regulates GO:0009395 ! phospholipid catabolic process [Term] id: GO:0060698 name: endoribonuclease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an endoribonuclease, any enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb] is_a: GO:0008428 ! ribonuclease inhibitor activity [Term] id: GO:0060699 name: regulation of endoribonuclease activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb] is_a: GO:0060700 ! regulation of ribonuclease activity [Term] id: GO:0060700 name: regulation of ribonuclease activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb] is_a: GO:0032069 ! regulation of nuclease activity [Term] id: GO:0060701 name: negative regulation of ribonuclease activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb] is_a: GO:0032074 ! negative regulation of nuclease activity is_a: GO:0060700 ! regulation of ribonuclease activity [Term] id: GO:0060702 name: negative regulation of endoribonuclease activity namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb] is_a: GO:0060699 ! regulation of endoribonuclease activity is_a: GO:0060701 ! negative regulation of ribonuclease activity [Term] id: GO:0060703 name: deoxyribonuclease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of deoxyribonuclease." [GOC:dph, GOC:tb] synonym: "DNase inhibitor activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0060704 name: acinar cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize an acinar cell of the salivary gland. Acinar cells are protein-secreting cells in the gland." [GOC:dph] is_a: GO:0060689 ! cell differentiation involved in salivary gland development [Term] id: GO:0060705 name: neuron differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the neurons of the salivary gland." [GOC:dph] is_a: GO:0030182 ! neuron differentiation is_a: GO:0060689 ! cell differentiation involved in salivary gland development [Term] id: GO:0060706 name: cell differentiation involved in embryonic placenta development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta." [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001892 ! embryonic placenta development [Term] id: GO:0060707 name: trophoblast giant cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua." [GOC:dph, PMID:16269175] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development [Term] id: GO:0060708 name: spongiotrophoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell." [GOC:dph, PMID:16269175] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development relationship: part_of GO:0060712 ! spongiotrophoblast layer development [Term] id: GO:0060709 name: glycogen cell development involved in embryonic placenta development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer." [GOC:dph, PMID:16269175] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development relationship: part_of GO:0060712 ! spongiotrophoblast layer development [Term] id: GO:0060710 name: chorio-allantoic fusion namespace: biological_process def: "The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois." [GOC:dph] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis [Term] id: GO:0060711 name: labyrinthine layer development namespace: biological_process def: "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001892 ! embryonic placenta development [Term] id: GO:0060712 name: spongiotrophoblast layer development namespace: biological_process def: "The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001892 ! embryonic placenta development [Term] id: GO:0060713 name: labyrinthine layer morphogenesis namespace: biological_process def: "The process in which the labyrinthine layer of the placenta is generated and organized." [GOC:dph] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060711 ! labyrinthine layer development [Term] id: GO:0060714 name: labyrinthine layer formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta." [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis [Term] id: GO:0060715 name: syncytiotrophoblast cell differentiation involved in labyrinthine layer development namespace: biological_process def: "The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta." [GOC:dph] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development relationship: part_of GO:0060711 ! labyrinthine layer development [Term] id: GO:0060716 name: labyrinthine layer blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GOC:dph] is_a: GO:0048568 ! embryonic organ development is_a: GO:0060674 ! placenta blood vessel development relationship: part_of GO:0060711 ! labyrinthine layer development [Term] id: GO:0060717 name: chorion development namespace: biological_process def: "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane." [GOC:dph] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0060718 name: chorionic trophoblast cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [GOC:dph, PMID:16983341] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060717 ! chorion development [Term] id: GO:0060719 name: chorionic trophoblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:16983341, GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0060718 ! chorionic trophoblast cell differentiation [Term] id: GO:0060720 name: spongiotrophoblast cell proliferation namespace: biological_process def: "The multiplication or reproduction of spongiotrophoblast cells, resulting in the expansion of the population in the spongiotrophoblast layer." [GOC:dph] is_a: GO:0060722 ! cell proliferation involved in embryonic placenta development relationship: part_of GO:0090214 ! spongiotrophoblast layer developmental growth [Term] id: GO:0060721 name: regulation of spongiotrophoblast cell proliferation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation." [GOC:dph] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0060723 ! regulation of cell proliferation involved in embryonic placenta development relationship: regulates GO:0060720 ! spongiotrophoblast cell proliferation [Term] id: GO:0060722 name: cell proliferation involved in embryonic placenta development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta." [GOC:dph] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0001892 ! embryonic placenta development [Term] id: GO:0060723 name: regulation of cell proliferation involved in embryonic placenta development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development." [GOC:dph] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development [Term] id: GO:0060724 name: coreceptor activity involved in epidermal growth factor receptor signaling pathway namespace: molecular_function def: "Combining with an extracellular messenger, and in cooperation with a primary EGF receptor, initiating a change in cell activity through the EGF receptor signaling pathway." [GOC:dph, GOC:tb] synonym: "coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0015026 ! coreceptor activity [Term] id: GO:0060725 name: regulation of coreceptor activity namespace: biological_process def: "Any process that modulates the rate or frequency of coreceptor activity, combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:dph, GOC:tb] is_a: GO:0010469 ! regulation of receptor activity [Term] id: GO:0060726 name: regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb] synonym: "regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb] is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway is_a: GO:0060725 ! regulation of coreceptor activity [Term] id: GO:0060727 name: positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that increases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb] synonym: "positive regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb] is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway is_a: GO:2000273 ! positive regulation of receptor activity [Term] id: GO:0060728 name: negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb] synonym: "negative regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb] is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway is_a: GO:2000272 ! negative regulation of receptor activity [Term] id: GO:0060729 name: intestinal epithelial structure maintenance namespace: biological_process def: "A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb] synonym: "epithelial structure maintenance of intestine" EXACT [GOC:dph, GOC:tb] synonym: "maintenance of intestinal epithelium" EXACT [GOC:dph, GOC:tb] is_a: GO:0030277 ! maintenance of gastrointestinal epithelium [Term] id: GO:0060730 name: regulation of intestinal epithelial structure maintenance namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0044058 ! regulation of digestive system process relationship: regulates GO:0060729 ! intestinal epithelial structure maintenance [Term] id: GO:0060731 name: positive regulation of intestinal epithelial structure maintenance namespace: biological_process def: "Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:dph, GOC:tb] is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0060456 ! positive regulation of digestive system process is_a: GO:0060730 ! regulation of intestinal epithelial structure maintenance relationship: positively_regulates GO:0060729 ! intestinal epithelial structure maintenance [Term] id: GO:0060732 name: positive regulation of inositol phosphate biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process relationship: positively_regulates GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0060733 name: regulation of eIF2 alpha phosphorylation by amino acid starvation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation." [GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0034198 ! cellular response to amino acid starvation is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation [Term] id: GO:0060734 name: regulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress." [GOC:dph, GOC:tb] synonym: "regulation of eIF2 alpha phosphorylation by ER stress" EXACT [GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation [Term] id: GO:0060735 name: regulation of eIF2 alpha phosphorylation by dsRNA namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA." [GOC:dph, GOC:tb] synonym: "regulation of eIF2 alpha phosphorylation by double-stranded RNA" EXACT [GOC:dph] synonym: "regulation of eIF2 alpha phosphorylation by PKR" NARROW [GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0071359 ! cellular response to dsRNA is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation [Term] id: GO:0060736 name: prostate gland growth namespace: biological_process def: "The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048589 ! developmental growth relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060737 name: prostate gland morphogenetic growth namespace: biological_process def: "The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form." [GOC:dph] synonym: "prostate gland growth involved in morphogenesis" EXACT [GOC:dph] is_a: GO:0060560 ! developmental growth involved in morphogenesis is_a: GO:0060736 ! prostate gland growth relationship: part_of GO:0060512 ! prostate gland morphogenesis [Term] id: GO:0060738 name: epithelial-mesenchymal signaling involved in prostate gland development namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time." [GOC:dph] synonym: "epithelial-mesenchymal signalling involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0060684 ! epithelial-mesenchymal cell signaling relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060739 name: mesenchymal-epithelial cell signaling involved in prostate gland development namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time." [GOC:dph] synonym: "mesenchymal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0060638 ! mesenchymal-epithelial cell signaling relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060740 name: prostate gland epithelium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0060512 ! prostate gland morphogenesis [Term] id: GO:0060741 name: prostate gland stromal morphogenesis namespace: biological_process def: "The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060512 ! prostate gland morphogenesis [Term] id: GO:0060742 name: epithelial cell differentiation involved in prostate gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060743 name: epithelial cell maturation involved in prostate gland development namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] synonym: "prostate gland epithelial cell development" EXACT [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0060742 ! epithelial cell differentiation involved in prostate gland development [Term] id: GO:0060744 name: mammary gland branching involved in thelarche namespace: biological_process def: "The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, PMID:19261859] synonym: "mammary gland branching involved in puberty" RELATED [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis relationship: part_of GO:0042695 ! thelarche [Term] id: GO:0060745 name: mammary gland branching involved in pregnancy namespace: biological_process def: "The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy." [GOC:dph, PMID:19261859] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060135 ! maternal process involved in female pregnancy is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis [Term] id: GO:0060746 name: parental behavior namespace: biological_process def: "A reproductive behavior in which a parent cares for and rears offspring." [GOC:dph] is_a: GO:0033057 ! multicellular organismal reproductive behavior [Term] id: GO:0060747 name: oral incubation namespace: biological_process def: "A parental behavior in which fertilized eggs are taken into the mouth and held until hatching." [GOC:dph] is_a: GO:0060746 ! parental behavior [Term] id: GO:0060748 name: tertiary branching involved in mammary gland duct morphogenesis namespace: biological_process def: "The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy." [GOC:dph, PMID:18614704] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048754 ! branching morphogenesis of a tube is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0060745 ! mammary gland branching involved in pregnancy [Term] id: GO:0060749 name: mammary gland alveolus development namespace: biological_process def: "The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061377 ! mammary gland lobule development [Term] id: GO:0060750 name: epithelial cell proliferation involved in mammary gland duct elongation namespace: biological_process def: "The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth." [GOC:dph] is_a: GO:0033598 ! mammary gland epithelial cell proliferation relationship: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching [Term] id: GO:0060751 name: branch elongation involved in mammary gland duct branching namespace: biological_process def: "The developmental growth process in which a branch of a mammary gland duct elongates." [GOC:dph] synonym: "mammary gland duct branch elongation" EXACT [GOC:dph] is_a: GO:0060602 ! branch elongation of an epithelium relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis [Term] id: GO:0060752 name: intestinal phytosterol absorption namespace: biological_process def: "Any process in which phytosterols are taken up from the contents of the intestine." [GOC:dph, GOC:tb] is_a: GO:0015918 ! sterol transport is_a: GO:0050892 ! intestinal absorption [Term] id: GO:0060753 name: regulation of mast cell chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis relationship: regulates GO:0002551 ! mast cell chemotaxis [Term] id: GO:0060754 name: positive regulation of mast cell chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0060753 ! regulation of mast cell chemotaxis relationship: positively_regulates GO:0002551 ! mast cell chemotaxis [Term] id: GO:0060755 name: negative regulation of mast cell chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0060753 ! regulation of mast cell chemotaxis relationship: negatively_regulates GO:0002551 ! mast cell chemotaxis [Term] id: GO:0060756 name: foraging behavior namespace: biological_process def: "Behavior by which an organism locates food." [GOC:dph, GOC:tb] is_a: GO:0007610 ! behavior [Term] id: GO:0060757 name: adult foraging behavior namespace: biological_process def: "Behavior by which an adult locates food." [GOC:dph, GOC:tb] is_a: GO:0060756 ! foraging behavior [Term] id: GO:0060758 name: foraging behavior by probing substrate namespace: biological_process def: "Foraging behavior in which an anatomical part of the organism is inserted into the substrate to locate food." [GOC:dph, GOC:tb] is_a: GO:0060756 ! foraging behavior [Term] id: GO:0060759 name: regulation of response to cytokine stimulus namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0034097 ! response to cytokine stimulus [Term] id: GO:0060760 name: positive regulation of response to cytokine stimulus namespace: biological_process def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus relationship: positively_regulates GO:0034097 ! response to cytokine stimulus [Term] id: GO:0060761 name: negative regulation of response to cytokine stimulus namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus relationship: negatively_regulates GO:0034097 ! response to cytokine stimulus [Term] id: GO:0060762 name: regulation of branching involved in mammary gland duct morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0060444 ! branching involved in mammary gland duct morphogenesis [Term] id: GO:0060763 name: mammary duct terminal end bud growth namespace: biological_process def: "The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty." [GOC:dph, PMID:10804170] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060603 ! mammary gland duct morphogenesis [Term] id: GO:0060764 name: cell-cell signaling involved in mammary gland development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure." [GOC:dph] synonym: "cell-cell signalling involved in mammary gland development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0060765 name: regulation of androgen receptor signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph] synonym: "regulation of androgen receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway relationship: regulates GO:0030521 ! androgen receptor signaling pathway [Term] id: GO:0060766 name: negative regulation of androgen receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph] synonym: "negative regulation of androgen receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0033144 ! negative regulation of steroid hormone receptor signaling pathway is_a: GO:0060765 ! regulation of androgen receptor signaling pathway relationship: negatively_regulates GO:0030521 ! androgen receptor signaling pathway [Term] id: GO:0060767 name: epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060768 name: regulation of epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050678 ! regulation of epithelial cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development [Term] id: GO:0060769 name: positive regulation of epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development [Term] id: GO:0060770 name: negative regulation of epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development [Term] id: GO:0060771 name: phyllotactic patterning namespace: biological_process def: "The radial pattern formation process that results in the formation of leaf or flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009956 ! radial pattern formation [Term] id: GO:0060772 name: leaf phyllotactic patterning namespace: biological_process def: "The radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060771 ! phyllotactic patterning [Term] id: GO:0060773 name: flower phyllotactic patterning namespace: biological_process def: "The radial pattern formation process that results in the formation of flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060771 ! phyllotactic patterning [Term] id: GO:0060774 name: auxin mediated signaling pathway involved in phyllotactic patterning namespace: biological_process def: "The series of molecular signals generated in response to detection of auxin that contributes to the radial pattern formation process resulting in the formation of leaf or flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "auxin mediated signalling pathway involved in phyllotactic patterning" EXACT [GOC:mah] is_a: GO:0009734 ! auxin mediated signaling pathway relationship: part_of GO:0060771 ! phyllotactic patterning [Term] id: GO:0060775 name: planar cell polarity pathway involved in gastrula mediolateral intercalation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway relationship: part_of GO:0060031 ! mediolateral intercalation [Term] id: GO:0060776 name: simple leaf morphogenesis namespace: biological_process def: "The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009965 ! leaf morphogenesis [Term] id: GO:0060777 name: compound leaf morphogenesis namespace: biological_process def: "The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009965 ! leaf morphogenesis [Term] id: GO:0060778 name: primary leaflet morphogenesis namespace: biological_process def: "The process in which the primary leaflet attains its shape. A primary leaflet is a leaflet that develops directly from the rachis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060794 ! leaflet morphogenesis [Term] id: GO:0060779 name: secondary leaflet morphogenesis namespace: biological_process def: "The process in which the secondary leaflet attains its shape. A secondary leaflet develops by branching or division of a primary leaflet." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060794 ! leaflet morphogenesis [Term] id: GO:0060780 name: intercalary leaflet morphogenesis namespace: biological_process def: "The process in which the intercalary leaflet attains its shape. An intercalary leaflet is a leaflet that develops between primary leaflets." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060794 ! leaflet morphogenesis [Term] id: GO:0060781 name: mesenchymal cell proliferation involved in prostate gland development namespace: biological_process def: "The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph, PMID:12221011] is_a: GO:0010463 ! mesenchymal cell proliferation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060782 name: regulation of mesenchymal cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, PMID:12221011] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0060781 ! mesenchymal cell proliferation involved in prostate gland development [Term] id: GO:0060783 name: mesenchymal smoothened signaling pathway involved in prostate gland development namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development." [PMID:12221011] synonym: "mesenchymal hedgehog signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd] synonym: "mesenchymal hh signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd] synonym: "mesenchymal smoothened signalling pathway involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0060738 ! epithelial-mesenchymal signaling involved in prostate gland development [Term] id: GO:0060784 name: regulation of cell proliferation involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph] is_a: GO:0042127 ! regulation of cell proliferation relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0060785 name: regulation of apoptosis involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." [GOC:dph] is_a: GO:0042981 ! regulation of apoptosis relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0060786 name: regulation of cell differentiation involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." [GOC:dph] is_a: GO:0045595 ! regulation of cell differentiation relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0060787 name: positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that increases the rate or extent of the formation of the posterior neural plate, the posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "positive regulation of posterior neural plate formation by FGF receptor signaling pathway" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of posterior neural plate formation by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000027 ! regulation of organ morphogenesis relationship: positively_regulates GO:0090018 ! posterior neural plate formation [Term] id: GO:0060788 name: ectodermal placode formation namespace: biological_process def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0071697 ! ectodermal placode morphogenesis [Term] id: GO:0060789 name: hair follicle placode formation namespace: biological_process def: "The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0001942 ! hair follicle development [Term] id: GO:0060790 name: tooth placode formation namespace: biological_process def: "The developmental process in which the tooth placode forms. An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0042475 ! odontogenesis of dentine-containing tooth [Term] id: GO:0060791 name: sebaceous gland placode formation namespace: biological_process def: "The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0048733 ! sebaceous gland development [Term] id: GO:0060792 name: sweat gland development namespace: biological_process def: "The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048732 ! gland development [Term] id: GO:0060793 name: sweat gland placode formation namespace: biological_process def: "The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0060792 ! sweat gland development [Term] id: GO:0060794 name: leaflet morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the leaflet are generated and organized." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060777 ! compound leaf morphogenesis [Term] id: GO:0060795 name: cell fate commitment involved in formation of primary germ layers namespace: biological_process def: "The commitment of cells to specific cell fates of the endoderm, ectoderm and mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001704 ! formation of primary germ layer [Term] id: GO:0060796 name: regulation of transcription involved in primary germ layer cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0060795 ! cell fate commitment involved in formation of primary germ layers [Term] id: GO:0060797 name: transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt a mesoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in primary germ layer cell fate commitment" EXACT [GOC:mah] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: part_of GO:0060795 ! cell fate commitment involved in formation of primary germ layers [Term] id: GO:0060798 name: transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah] is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment relationship: part_of GO:0007501 ! mesodermal cell fate specification [Term] id: GO:0060799 name: transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in endodermal cell fate specification" EXACT [GOC:mah] is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment relationship: part_of GO:0001714 ! endodermal cell fate specification [Term] id: GO:0060800 name: regulation of cell differentiation involved in embryonic placenta development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development [Term] id: GO:0060801 name: negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway namespace: biological_process def: "The transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "negative regulation of trophoblast cell differentiation by transforming growth factor beta signalling pathway" EXACT [GOC:mah] is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development [Term] id: GO:0060802 name: epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification namespace: biological_process def: "Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "epiblast cell-extraembryonic ectoderm cell signalling involved in anterior/posterior axis specification" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0009948 ! anterior/posterior axis specification [Term] id: GO:0060803 name: BMP signaling pathway involved in mesodermal cell fate specification namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and ultimately resulting in an cell becoming specified to adopt a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "BMP signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0007501 ! mesodermal cell fate specification [Term] id: GO:0060804 name: positive regulation of WNT receptor signaling pathway by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a WNT receptor signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "positive regulation of WNT receptor signalling pathway by BMP signalling pathway" EXACT [GOC:mah] is_a: GO:0030177 ! positive regulation of Wnt receptor signaling pathway is_a: GO:0030509 ! BMP signaling pathway [Term] id: GO:0060805 name: negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development [Term] id: GO:0060806 name: negative regulation of cell differentiation involved in embryonic placenta development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060800 ! regulation of cell differentiation involved in embryonic placenta development relationship: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development [Term] id: GO:0060807 name: regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that ultimately results in a cell being specified to adopt a definitive endodermal cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060796 ! regulation of transcription involved in primary germ layer cell fate commitment relationship: part_of GO:0001714 ! endodermal cell fate specification [Term] id: GO:0060808 name: positive regulation of mesodermal to mesenchymal transition involved in gastrulation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition relationship: positively_regulates GO:0060809 ! mesodermal to mesenchymal transition involved in gastrulation [Term] id: GO:0060809 name: mesodermal to mesenchymal transition involved in gastrulation namespace: biological_process def: "The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001837 ! epithelial to mesenchymal transition is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0060810 name: intracellular mRNA localization involved in pattern specification process namespace: biological_process def: "Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "intracellular mRNA localisation involved in pattern specification process" EXACT [GOC:mah] is_a: GO:0008298 ! intracellular mRNA localization relationship: part_of GO:0007389 ! pattern specification process [Term] id: GO:0060811 name: intracellular mRNA localization involved in anterior/posterior axis specification namespace: biological_process def: "Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "intracellular mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah] is_a: GO:0060810 ! intracellular mRNA localization involved in pattern specification process relationship: part_of GO:0009948 ! anterior/posterior axis specification [Term] id: GO:0060812 name: orthodenticle mRNA localization namespace: biological_process def: "Any process in which orthodenticle mRNA is transported to and maintained in the oocyte and/or syncytial embryo as part of the process that will specify the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "orthodenticle mRNA localisation" EXACT [GOC:mah] is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification [Term] id: GO:0060813 name: anterior mRNA localization involved in anterior/posterior axis specification namespace: biological_process def: "Any process in which a mRNA is transported to, and maintained in the anterior portion of the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "anterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah] is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification [Term] id: GO:0060814 name: posterior mRNA localization involved in anterior/posterior axis specification namespace: biological_process def: "Any process in which a mRNA is transported to and maintained in the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "posterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah] is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification [Term] id: GO:0060815 name: regulation of translation involved in anterior/posterior axis specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0006417 ! regulation of translation relationship: part_of GO:0009948 ! anterior/posterior axis specification [Term] id: GO:0060816 name: random inactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome [Term] id: GO:0060817 name: inactivation of paternal X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome [Term] id: GO:0060818 name: inactivation of paternal X chromosome by genetic imprinting namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genetic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060817 ! inactivation of paternal X chromosome is_a: GO:0060819 ! inactivation of X chromosome by genetic imprinting [Term] id: GO:0060819 name: inactivation of X chromosome by genetic imprinting namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genetic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0006349 ! regulation of gene expression by genetic imprinting is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome [Term] id: GO:0060820 name: inactivation of X chromosome by heterochromatin formation namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome is_a: GO:0031507 ! heterochromatin formation [Term] id: GO:0060821 name: inactivation of X chromosome by DNA methylation namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by a mechanism of DNA methylation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome [Term] id: GO:0060822 name: transforming growth factor beta receptor signaling pathway involved in axial mesodermal cell fate specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of an axial mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in axial mesodermal cell fate specification" EXACT [GOC:mah] is_a: GO:0060798 ! transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification relationship: part_of GO:0048327 ! axial mesodermal cell fate specification [Term] id: GO:0060823 name: canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] synonym: "Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0060824 name: retinoic acid receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the formation of the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "retinoic acid receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0060825 name: fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0060826 name: transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands, contributing to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0060827 name: regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of Wnt receptor signaling through beta-catenin that results in the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0060828 ! regulation of canonical Wnt receptor signaling pathway relationship: regulates GO:0060823 ! canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation [Term] id: GO:0060828 name: regulation of canonical Wnt receptor signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway relationship: regulates GO:0060070 ! canonical Wnt receptor signaling pathway [Term] id: GO:0060829 name: negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal] is_a: GO:0060827 ! regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation is_a: GO:0090090 ! negative regulation of canonical Wnt receptor signaling pathway [Term] id: GO:0060830 name: ciliary receptor clustering involved in smoothened signaling pathway namespace: biological_process def: "Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "ciliary receptor clustering involved in hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "ciliary receptor clustering involved in hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "ciliary receptor clustering involved in smoothened signalling pathway" EXACT [GOC:mah] is_a: GO:0043113 ! receptor clustering relationship: part_of GO:0007224 ! smoothened signaling pathway [Term] id: GO:0060831 name: smoothened signaling pathway involved in dorsal/ventral neural tube patterning namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0021904 ! dorsal/ventral neural tube patterning [Term] id: GO:0060832 name: oocyte animal/vegetal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007309 ! oocyte axis specification [Term] id: GO:0060833 name: Wnt receptor signaling pathway involved in animal/vegetal axis specification namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the specification of the animal/vegetal axis of an oocyte." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "Wnt receptor signalling pathway involved in animal/vegetal axis specification" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0060832 ! oocyte animal/vegetal axis specification [Term] id: GO:0060834 name: oral/aboral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "oral/aboral axis determination" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification [Term] id: GO:0060835 name: transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the specification of the oral/aboral axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor receptor beta signalling pathway involved in oral/aboral axis specification" EXACT [GOC:mah] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: part_of GO:0060834 ! oral/aboral axis specification [Term] id: GO:0060836 name: lymphatic endothelial cell differentiation namespace: biological_process def: "The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045446 ! endothelial cell differentiation relationship: part_of GO:0001945 ! lymph vessel development [Term] id: GO:0060837 name: blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045446 ! endothelial cell differentiation relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0060838 name: lymphatic endothelial cell fate commitment namespace: biological_process def: "The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060839 ! endothelial cell fate commitment relationship: part_of GO:0060836 ! lymphatic endothelial cell differentiation [Term] id: GO:0060839 name: endothelial cell fate commitment namespace: biological_process def: "The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0045446 ! endothelial cell differentiation [Term] id: GO:0060840 name: artery development namespace: biological_process def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development [Term] id: GO:0060841 name: venous blood vessel development namespace: biological_process def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development [Term] id: GO:0060842 name: arterial endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation [Term] id: GO:0060843 name: venous endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation [Term] id: GO:0060844 name: arterial endothelial cell fate commitment namespace: biological_process def: "The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060846 ! blood vessel endothelial cell fate commitment relationship: part_of GO:0060842 ! arterial endothelial cell differentiation [Term] id: GO:0060845 name: venous endothelial cell fate commitment namespace: biological_process def: "The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060846 ! blood vessel endothelial cell fate commitment relationship: part_of GO:0060843 ! venous endothelial cell differentiation [Term] id: GO:0060846 name: blood vessel endothelial cell fate commitment namespace: biological_process def: "The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060839 ! endothelial cell fate commitment relationship: part_of GO:0060837 ! blood vessel endothelial cell differentiation [Term] id: GO:0060847 name: endothelial cell fate specification namespace: biological_process def: "The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0060839 ! endothelial cell fate commitment [Term] id: GO:0060848 name: endothelial cell fate determination namespace: biological_process def: "A process involved in cell fate commitment of an endothelial cell. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0060839 ! endothelial cell fate commitment [Term] id: GO:0060849 name: regulation of transcription involved in lymphatic endothelial cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment [Term] id: GO:0060850 name: regulation of transcription involved in cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter [Term] id: GO:0060851 name: vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "vascular endothelial growth factor receptor signalling pathway involved in lymphatic endothelial cell fate commitment" EXACT [GOC:mah] is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment [Term] id: GO:0060852 name: regulation of transcription involved in venous endothelial cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate and contributes to a cell adopting a venous endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060845 ! venous endothelial cell fate commitment is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment [Term] id: GO:0060853 name: Notch signaling pathway involved in arterial endothelial cell fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "Notch signalling pathway involved in arterial endothelial cell fate commitment" EXACT [GOC:mah] is_a: GO:0007219 ! Notch signaling pathway relationship: part_of GO:0060844 ! arterial endothelial cell fate commitment [Term] id: GO:0060854 name: patterning of lymph vessels namespace: biological_process def: "The process that regulates the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0001946 ! lymphangiogenesis [Term] id: GO:0060855 name: venous endothelial cell migration involved in lymph vessel development namespace: biological_process def: "The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0001945 ! lymph vessel development [Term] id: GO:0060856 name: establishment of blood-brain barrier namespace: biological_process def: "Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] synonym: "establishment of BBB" EXACT [PMID:20080302] is_a: GO:0048468 ! cell development [Term] id: GO:0060857 name: establishment of glial blood-brain barrier namespace: biological_process def: "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] synonym: "establishment of glial BBB" EXACT [PMID:20080302] is_a: GO:0021782 ! glial cell development is_a: GO:0060856 ! establishment of blood-brain barrier [Term] id: GO:0060858 name: vesicle-mediated transport involved in floral organ abscission namespace: biological_process def: "The directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "membrane trafficking involved in floral organ shedding" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0010227 ! floral organ abscission [Term] id: GO:0060859 name: regulation of vesicle-mediated transport involved in floral organ abscission namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:0060860 ! regulation of floral organ abscission relationship: regulates GO:0060858 ! vesicle-mediated transport involved in floral organ abscission [Term] id: GO:0060860 name: regulation of floral organ abscission namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009909 ! regulation of flower development relationship: regulates GO:0010227 ! floral organ abscission [Term] id: GO:0060861 name: positive regulation of floral organ abscission namespace: biological_process def: "Any process that increases the rate, frequency, or extent of floral organ shedding, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0060860 ! regulation of floral organ abscission is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0010227 ! floral organ abscission [Term] id: GO:0060862 name: negative regulation of floral organ abscission namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0060860 ! regulation of floral organ abscission is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0010227 ! floral organ abscission [Term] id: GO:0060863 name: regulation of floral organ abscission by signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately modulating the rate, or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007165 ! signal transduction is_a: GO:0060860 ! regulation of floral organ abscission [Term] id: GO:0060864 name: positive regulation of floral organ abscission by small GTPase mediated signal transduction namespace: biological_process def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that increases the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007264 ! small GTPase mediated signal transduction is_a: GO:0060861 ! positive regulation of floral organ abscission is_a: GO:0060863 ! regulation of floral organ abscission by signal transduction [Term] id: GO:0060865 name: negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand and contributing to the decrease in the rate or frequency of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0060862 ! negative regulation of floral organ abscission [Term] id: GO:0060866 name: leaf abscission namespace: biological_process def: "The controlled shedding of a leaf." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009838 ! abscission [Term] id: GO:0060867 name: fruit abscission namespace: biological_process def: "The controlled shedding of a fruit." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009838 ! abscission [Term] id: GO:0060868 name: regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction namespace: biological_process def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that modulates the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007264 ! small GTPase mediated signal transduction is_a: GO:0060859 ! regulation of vesicle-mediated transport involved in floral organ abscission [Term] id: GO:0060869 name: transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission namespace: biological_process def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand that contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway involved in floral organ abscission" EXACT [GOC:mah] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0010227 ! floral organ abscission [Term] id: GO:0060870 name: cell wall disassembly involved in floral organ abscission namespace: biological_process def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009830 ! cell wall modification involved in abscission is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0010227 ! floral organ abscission [Term] id: GO:0060871 name: cellular cell wall disassembly namespace: biological_process def: "A cellular process that results in the breakdown of the cell wall." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007047 ! cellular cell wall organization is_a: GO:0022411 ! cellular component disassembly is_a: GO:0044277 ! cell wall disassembly [Term] id: GO:0060872 name: semicircular canal development namespace: biological_process def: "The progression of the semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048839 ! inner ear development [Term] id: GO:0060873 name: anterior semicircular canal development namespace: biological_process def: "The progession of the anterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060872 ! semicircular canal development [Term] id: GO:0060874 name: posterior semicircular canal development namespace: biological_process def: "The progession of the posterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060872 ! semicircular canal development [Term] id: GO:0060875 name: lateral semicircular canal development namespace: biological_process def: "The progession of the lateral semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060872 ! semicircular canal development [Term] id: GO:0060876 name: semicircular canal formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048752 ! semicircular canal morphogenesis [Term] id: GO:0060877 name: regionalization involved in semicircular canal formation namespace: biological_process def: "The pattern specification process that results in the subdivision of the otic epithelium in space to define an area or volume in which cells will differentiate to give rise to the semicircular canals." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization relationship: part_of GO:0060876 ! semicircular canal formation [Term] id: GO:0060878 name: pouch outgrowth involved in semicircular canal formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0060876 ! semicircular canal formation [Term] id: GO:0060879 name: semicircular canal fusion namespace: biological_process def: "Creation of the central hole of the semicircular canal by sealing the edges of the pouch that forms ruing the process of semicircular canal formation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060606 ! tube closure relationship: part_of GO:0060876 ! semicircular canal formation [Term] id: GO:0060880 name: cell morphogenesis involved in semicircular canal fusion namespace: biological_process def: "The change in form (cell shape and size) that occurs when a semicircular canal epithelial cell acquires the structural features that allow it to contribute to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060879 ! semicircular canal fusion [Term] id: GO:0060881 name: basal lamina disassembly namespace: biological_process def: "A process that results in the breakdown of the basal lamina." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0022617 ! extracellular matrix disassembly [Term] id: GO:0060882 name: basal lamina disassembly involved in semicircular canal fusion namespace: biological_process def: "A process that results in the breakdown of the basal lamina that contributes to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060881 ! basal lamina disassembly relationship: part_of GO:0060879 ! semicircular canal fusion [Term] id: GO:0060883 name: regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basal lamina disassembly involved in semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007154 ! cell communication is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:0045995 ! regulation of embryonic development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0060882 ! basal lamina disassembly involved in semicircular canal fusion [Term] id: GO:0060884 name: clearance of cells from fusion plate namespace: biological_process def: "The morphogenetic process in which cells are removed from the inner loop of a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048752 ! semicircular canal morphogenesis [Term] id: GO:0060885 name: clearance of cells from fusion plate by apoptosis namespace: biological_process def: "The process of apoptosis that contributes to the shaping of the semicircular canal by removing cells in the fusion plate, forming the loops of the canals." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060561 ! apoptosis involved in morphogenesis is_a: GO:0060884 ! clearance of cells from fusion plate [Term] id: GO:0060886 name: clearance of cells from fusion plate by epithelial to mesenchymal transition namespace: biological_process def: "The process of epithelial to mesenchymal transition that contributes to the shaping of the semicircular canal by effectively removing epithelial cells from the fusion plate, forming the loops of the canals." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001837 ! epithelial to mesenchymal transition is_a: GO:0060884 ! clearance of cells from fusion plate [Term] id: GO:0060887 name: limb epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0008544 ! epidermis development relationship: part_of GO:0060173 ! limb development [Term] id: GO:0060888 name: limb epidermis stratification namespace: biological_process def: "The pattern specification process that results in the subdivision of the epidermis of the limb in space to define a volume in which specific patterns of basal cell, spinous cell and granular cells will differentiate giving rise to the layers of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0060887 ! limb epidermis development [Term] id: GO:0060889 name: limb basal epidermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal basal cell. A epidermal basal cell cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into more specialized cell of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009913 ! epidermal cell differentiation is_a: GO:0048863 ! stem cell differentiation relationship: part_of GO:0060887 ! limb epidermis development [Term] id: GO:0060890 name: limb spinous cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal spinous cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0030216 ! keratinocyte differentiation relationship: part_of GO:0060887 ! limb epidermis development [Term] id: GO:0060891 name: limb granular cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal granular cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0030216 ! keratinocyte differentiation relationship: part_of GO:0060887 ! limb epidermis development [Term] id: GO:0060892 name: limb basal epidermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009957 ! epidermal cell fate specification relationship: part_of GO:0060888 ! limb epidermis stratification relationship: part_of GO:0060889 ! limb basal epidermal cell differentiation [Term] id: GO:0060893 name: limb granular cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009957 ! epidermal cell fate specification relationship: part_of GO:0060888 ! limb epidermis stratification relationship: part_of GO:0060891 ! limb granular cell differentiation [Term] id: GO:0060894 name: limb spinous cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009957 ! epidermal cell fate specification relationship: part_of GO:0060888 ! limb epidermis stratification relationship: part_of GO:0060890 ! limb spinous cell differentiation [Term] id: GO:0060895 name: retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the dorsal ventral patterning of the spinal cord." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "retinoic acid receptor signalling pathway involved in spinal cord dorsal/ventral patterning" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning [Term] id: GO:0060896 name: neural plate pattern specification namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0060897 name: neural plate regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization relationship: part_of GO:0060896 ! neural plate pattern specification [Term] id: GO:0060898 name: eye field cell fate commitment involved in camera-type eye formation namespace: biological_process def: "The commitment of neurectodermal cells to cells of the eye field and their capacity to differentiate into eye field cells. Eye field cells are neurectodermal cells that will form the optic placode." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0046619 ! optic placode formation involved in camera-type eye formation relationship: part_of GO:0060897 ! neural plate regionalization [Term] id: GO:0060899 name: regulation of transcription involved in eye field cell fate commitment of camera-type eye namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neurectodermal cell to a specialized neurectodermal cell that will give rise to the optic vesicle." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0060898 ! eye field cell fate commitment involved in camera-type eye formation [Term] id: GO:0060900 name: embryonic camera-type eye formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis [Term] id: GO:0060901 name: regulation of hair cycle by canonical Wnt receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of hair cycle by canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of hair cycle by Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0060070 ! canonical Wnt receptor signaling pathway [Term] id: GO:0060902 name: regulation of hair cycle by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of hair cycle by BMP signalling pathway" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0042634 ! regulation of hair cycle [Term] id: GO:0060903 name: positive regulation of meiosis I namespace: biological_process def: "Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb] is_a: GO:0060631 ! regulation of meiosis I is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0007127 ! meiosis I [Term] id: GO:0060904 name: regulation of protein folding in endoplasmic reticulum namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:dph, GOC:tb] is_a: GO:0032268 ! regulation of cellular protein metabolic process relationship: regulates GO:0034975 ! protein folding in endoplasmic reticulum [Term] id: GO:0060905 name: regulation of induction of conjugation upon nitrogen starvation namespace: biological_process def: "Any process that modulates the frequency of induction of conjugation upon nitrogen starvation, the process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0031142 ! induction of conjugation upon nitrogen starvation [Term] id: GO:0060906 name: negative regulation of chromatin silencing by small RNA namespace: biological_process def: "Any process that decreases the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:tb] is_a: GO:0010964 ! regulation of chromatin silencing by small RNA is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0060967 ! negative regulation of gene silencing by RNA relationship: negatively_regulates GO:0031048 ! chromatin silencing by small RNA [Term] id: GO:0060907 name: positive regulation of macrophage cytokine production namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:dph, GOC:tb] is_a: GO:0010935 ! regulation of macrophage cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response relationship: positively_regulates GO:0010934 ! macrophage cytokine production [Term] id: GO:0060908 name: plasmid copy number maintenance namespace: biological_process def: "The maintenance of the number of copies of extrachromosomal plasmid DNA." [GOC:dph, GOC:tb] is_a: GO:0006276 ! plasmid maintenance [Term] id: GO:0060909 name: regulation of DNA replication initiation involved in plasmid copy number maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation relationship: part_of GO:0060908 ! plasmid copy number maintenance [Term] id: GO:0060910 name: negative regulation of DNA replication initiation involved in plasmid copy number maintenance namespace: biological_process def: "Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb] is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation is_a: GO:0060909 ! regulation of DNA replication initiation involved in plasmid copy number maintenance [Term] id: GO:0060911 name: cardiac cell fate commitment namespace: biological_process def: "The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system." [GOC:mtg_heart] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0035051 ! cardiac cell differentiation [Term] id: GO:0060912 name: cardiac cell fate specification namespace: biological_process def: "The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:mtg_heart] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0060911 ! cardiac cell fate commitment [Term] id: GO:0060913 name: cardiac cell fate determination namespace: biological_process def: "The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:mtg_heart] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0060911 ! cardiac cell fate commitment [Term] id: GO:0060914 name: heart formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "cardiogenesis" RELATED [GOC:mtg_heart] is_a: GO:0048645 ! organ formation relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0060915 name: mesenchymal cell differentiation involved in lung development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060916 name: mesenchymal cell proliferation involved in lung development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph] is_a: GO:0010463 ! mesenchymal cell proliferation relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060917 name: regulation of 1,6-beta-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta-1,6 glucans." [GOC:dph, GOC:tb] is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process relationship: regulates GO:0006078 ! 1,6-beta-glucan biosynthetic process [Term] id: GO:0060918 name: auxin transport namespace: biological_process def: "The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0009914 ! hormone transport [Term] id: GO:0060919 name: auxin influx namespace: biological_process def: "The process involved in the transport of auxin into the cell." [GOC:dph, GOC:tb] is_a: GO:0060918 ! auxin transport [Term] id: GO:0060920 name: pacemaker cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_heart] is_a: GO:0055007 ! cardiac muscle cell differentiation [Term] id: GO:0060921 name: sinoatrial node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0060920 ! pacemaker cell differentiation relationship: part_of GO:0003163 ! sinoatrial node development [Term] id: GO:0060922 name: atrioventricular node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart] synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart] is_a: GO:0060920 ! pacemaker cell differentiation relationship: part_of GO:0003162 ! atrioventricular node development [Term] id: GO:0060923 name: cardiac muscle cell fate commitment namespace: biological_process def: "The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart] synonym: "cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart] synonym: "heart muscle cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0055007 ! cardiac muscle cell differentiation [Term] id: GO:0060924 name: atrial cardiac muscle cell fate commitment namespace: biological_process def: "The commitment of cells to atrial cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart] synonym: "atrial cardiomyocyte cell fate commitment" RELATED [GOC:mtg_heart] synonym: "atrial heart muscle cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060923 ! cardiac muscle cell fate commitment relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation [Term] id: GO:0060925 name: ventricular cardiac muscle cell fate commitment namespace: biological_process def: "The commitment of cells to ventricular cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the ventricle. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart] synonym: "ventricular cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart] synonym: "ventricular heart muscle cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060923 ! cardiac muscle cell fate commitment relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation [Term] id: GO:0060926 name: pacemaker cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_heart] is_a: GO:0055013 ! cardiac muscle cell development relationship: part_of GO:0060920 ! pacemaker cell differentiation [Term] id: GO:0060927 name: pacemaker cell fate commitment namespace: biological_process def: "The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_heart] is_a: GO:0060923 ! cardiac muscle cell fate commitment relationship: part_of GO:0060920 ! pacemaker cell differentiation [Term] id: GO:0060928 name: atrioventricular node cell development namespace: biological_process def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "AV node cell development" EXACT [GOC:mtg_heart] is_a: GO:0060926 ! pacemaker cell development relationship: part_of GO:0060922 ! atrioventricular node cell differentiation [Term] id: GO:0060929 name: atrioventricular node cell fate commitment namespace: biological_process def: "The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells." [GOC:mtg_heart] synonym: "AV node cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060927 ! pacemaker cell fate commitment relationship: part_of GO:0060922 ! atrioventricular node cell differentiation [Term] id: GO:0060930 name: sinoatrial node cell fate commitment namespace: biological_process def: "The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell commitment" EXACT [GOC:mtg_heart] is_a: GO:0060927 ! pacemaker cell fate commitment relationship: part_of GO:0060921 ! sinoatrial node cell differentiation [Term] id: GO:0060931 name: sinoatrial node cell development namespace: biological_process def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell development" EXACT [GOC:mtg_heart] is_a: GO:0060926 ! pacemaker cell development relationship: part_of GO:0060921 ! sinoatrial node cell differentiation [Term] id: GO:0060932 name: His-Purkinje system cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055007 ! cardiac muscle cell differentiation relationship: part_of GO:0003164 ! His-Purkinje system development [Term] id: GO:0060933 name: His-Purkinje system cell development namespace: biological_process def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation [Term] id: GO:0060934 name: His-Purkinje system cell fate commitment namespace: biological_process def: "The commitment of cells to His-Purkinje cell fates and their capacity to differentiate into His-Purkinje cells. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation [Term] id: GO:0060935 name: cardiac fibroblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0035051 ! cardiac cell differentiation [Term] id: GO:0060936 name: cardiac fibroblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation [Term] id: GO:0060937 name: cardiac fibroblast cell fate commitment namespace: biological_process def: "The commitment of cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation [Term] id: GO:0060938 name: epicardium-derived cardiac fibroblast cell differentiation namespace: biological_process def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060935 ! cardiac fibroblast cell differentiation [Term] id: GO:0060939 name: epicardium-derived cardiac fibroblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060936 ! cardiac fibroblast cell development relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation [Term] id: GO:0060940 name: epithelial to mesenchymal transition involved in cardiac fibroblast development namespace: biological_process def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0060939 ! epicardium-derived cardiac fibroblast cell development [Term] id: GO:0060941 name: epicardium-derived cardiac fibroblast cell fate commitment namespace: biological_process def: "The commitment of an epicardial cell to a cardiac fibroblast cell fate and its capacity to differentiate into a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060937 ! cardiac fibroblast cell fate commitment relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation [Term] id: GO:0060942 name: neural crest-derived cardiac fibroblast cell differentiation namespace: biological_process def: "The process in which a neural crest cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060935 ! cardiac fibroblast cell differentiation [Term] id: GO:0060943 name: neural crest-derived cardiac fibroblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation from a neural crest cell to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060936 ! cardiac fibroblast cell development relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation [Term] id: GO:0060944 name: neural crest-derived cardiac fibroblast cell fate commitment namespace: biological_process def: "The commitment of neural crest cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060937 ! cardiac fibroblast cell fate commitment relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation [Term] id: GO:0060945 name: cardiac neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart] synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart] is_a: GO:0030182 ! neuron differentiation is_a: GO:0035051 ! cardiac cell differentiation relationship: part_of GO:0048483 ! autonomic nervous system development [Term] id: GO:0060946 name: cardiac blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation is_a: GO:0060837 ! blood vessel endothelial cell differentiation [Term] id: GO:0060947 name: cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart] synonym: "heart vascular smooth muscle cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0035051 ! cardiac cell differentiation is_a: GO:0035886 ! vascular smooth muscle cell differentiation relationship: part_of GO:0060976 ! coronary vasculature development [Term] id: GO:0060948 name: cardiac vascular smooth muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "heart vascular smooth muscle cell development" EXACT [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation [Term] id: GO:0060949 name: cardiac vascular smooth muscle cell fate commitment namespace: biological_process def: "The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart] synonym: "heart vascular smooth muscle cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation [Term] id: GO:0060950 name: cardiac glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0035051 ! cardiac cell differentiation [Term] id: GO:0060951 name: neural crest-derived cardiac glial cell differentiation namespace: biological_process def: "The process in which a neural crest cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart] is_a: GO:0060950 ! cardiac glial cell differentiation [Term] id: GO:0060952 name: cardiac glial cell development namespace: biological_process def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart] is_a: GO:0021782 ! glial cell development is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060950 ! cardiac glial cell differentiation [Term] id: GO:0060953 name: cardiac glial cell fate commitment namespace: biological_process def: "The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart] is_a: GO:0021781 ! glial cell fate commitment is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060950 ! cardiac glial cell differentiation [Term] id: GO:0060954 name: neural crest-derived cardiac glial cell development namespace: biological_process def: "The process aimed at the progression of a neural crest-derived cardiac glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:mtg_heart] is_a: GO:0060952 ! cardiac glial cell development relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation [Term] id: GO:0060955 name: neural crest-derived cardiac glial cell fate commitment namespace: biological_process def: "The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart] is_a: GO:0060953 ! cardiac glial cell fate commitment relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation [Term] id: GO:0060956 name: endocardial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation is_a: GO:0045446 ! endothelial cell differentiation relationship: part_of GO:0003157 ! endocardium development [Term] id: GO:0060957 name: endocardial cell fate commitment namespace: biological_process def: "The commitment of a cell to an endocardial cell fate and its capacity to differentiate into an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart] is_a: GO:0060839 ! endothelial cell fate commitment is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060956 ! endocardial cell differentiation [Term] id: GO:0060958 name: endocardial cell development namespace: biological_process def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart] is_a: GO:0001885 ! endothelial cell development relationship: part_of GO:0060956 ! endocardial cell differentiation [Term] id: GO:0060959 name: cardiac neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "heart neuron development" EXACT [GOC:mtg_heart] is_a: GO:0048666 ! neuron development is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060945 ! cardiac neuron differentiation [Term] id: GO:0060960 name: cardiac neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron of the heart." [GOC:mtg_heart] synonym: "heart neuron fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0048663 ! neuron fate commitment is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060945 ! cardiac neuron differentiation [Term] id: GO:0060961 name: phospholipase D inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phospholipase D, an enzyme that catalyzes the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [GOC:dph, GOC:tb] is_a: GO:0004859 ! phospholipase inhibitor activity [Term] id: GO:0060962 name: regulation of ribosomal protein gene transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:dph, GOC:tb] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter [Term] id: GO:0060963 name: positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:dph, GOC:tb] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0060962 ! regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Term] id: GO:0060964 name: regulation of gene silencing by miRNA namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [GOC:dph, GOC:tb] is_a: GO:0060147 ! regulation of posttranscriptional gene silencing is_a: GO:0060966 ! regulation of gene silencing by RNA relationship: regulates GO:0035195 ! gene silencing by miRNA [Term] id: GO:0060965 name: negative regulation of gene silencing by miRNA namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [GOC:dph, GOC:tb] is_a: GO:0060149 ! negative regulation of posttranscriptional gene silencing is_a: GO:0060964 ! regulation of gene silencing by miRNA is_a: GO:0060967 ! negative regulation of gene silencing by RNA relationship: negatively_regulates GO:0035195 ! gene silencing by miRNA [Term] id: GO:0060966 name: regulation of gene silencing by RNA namespace: biological_process def: "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] is_a: GO:0060968 ! regulation of gene silencing relationship: regulates GO:0031047 ! gene silencing by RNA [Term] id: GO:0060967 name: negative regulation of gene silencing by RNA namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] is_a: GO:0060966 ! regulation of gene silencing by RNA is_a: GO:0060969 ! negative regulation of gene silencing relationship: negatively_regulates GO:0031047 ! gene silencing by RNA [Term] id: GO:0060968 name: regulation of gene silencing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0016458 ! gene silencing [Term] id: GO:0060969 name: negative regulation of gene silencing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0060968 ! regulation of gene silencing relationship: negatively_regulates GO:0016458 ! gene silencing [Term] id: GO:0060970 name: embryonic heart tube dorsal/ventral pattern formation namespace: biological_process def: "The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis." [GOC:mtg_heart] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0035050 ! embryonic heart tube development [Term] id: GO:0060971 name: embryonic heart tube left/right pattern formation namespace: biological_process def: "The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:mtg_heart] is_a: GO:0060972 ! left/right pattern formation relationship: part_of GO:0035050 ! embryonic heart tube development [Term] id: GO:0060972 name: left/right pattern formation namespace: biological_process def: "The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:mtg_heart] is_a: GO:0003002 ! regionalization [Term] id: GO:0060973 name: cell migration involved in heart development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart] is_a: GO:0016477 ! cell migration relationship: part_of GO:0007507 ! heart development [Term] id: GO:0060974 name: cell migration involved in heart formation namespace: biological_process def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development [Term] id: GO:0060975 name: cardioblast migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "cardiac progenitor cell midline migration" EXACT [GOC:mtg_heart] synonym: "cardioblast midline convergence" EXACT [GOC:mtg_heart] is_a: GO:0003260 ! cardioblast migration is_a: GO:0003318 ! cell migration to the midline involved in heart development relationship: part_of GO:0060029 ! convergent extension involved in organogenesis [Term] id: GO:0060976 name: coronary vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart vasculature development" EXACT [GOC:mtg_heart] is_a: GO:0001568 ! blood vessel development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0060977 name: coronary vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart] synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0060976 ! coronary vasculature development [Term] id: GO:0060978 name: angiogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart] synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart] synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001525 ! angiogenesis relationship: part_of GO:0060977 ! coronary vasculature morphogenesis [Term] id: GO:0060979 name: vasculogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart] synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart] synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001570 ! vasculogenesis relationship: part_of GO:0060977 ! coronary vasculature morphogenesis [Term] id: GO:0060980 name: cell migration involved in coronary vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart] is_a: GO:0035441 ! cell migration involved in vasculogenesis is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis [Term] id: GO:0060981 name: cell migration involved in coronary angiogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis [Term] id: GO:0060982 name: coronary artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle." [GOC:mtg_heart] is_a: GO:0048844 ! artery morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis [Term] id: GO:0060983 name: epicardium-derived cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart] is_a: GO:0060947 ! cardiac vascular smooth muscle cell differentiation [Term] id: GO:0060984 name: epicardium-derived cardiac vascular smooth muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell that was derived from the epicardium over time, from its formation to the mature state." [GOC:mtg_heart] is_a: GO:0060948 ! cardiac vascular smooth muscle cell development relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation [Term] id: GO:0060985 name: epicardium-derived cardiac vascular smooth muscle cell fate commitment namespace: biological_process def: "The commitment of an epicardial cell to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart] is_a: GO:0060949 ! cardiac vascular smooth muscle cell fate commitment relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation [Term] id: GO:0060986 name: endocrine hormone secretion namespace: biological_process def: "The regulated release of a hormone into the circulatory system." [GOC:dph] is_a: GO:0046879 ! hormone secretion relationship: part_of GO:0050886 ! endocrine process [Term] id: GO:0060987 name: lipid tube namespace: cellular_component def: "A macromolecular complex that contains a tube of lipid surrounded by a protein coat." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032994 ! protein-lipid complex [Term] id: GO:0060988 name: lipid tube assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as the fuse or undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "lipid tubulation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0034622 ! cellular macromolecular complex assembly [Term] id: GO:0060989 name: lipid tube assembly involved in organelle fusion namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "lipid tubulation involved in organelle fusion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060988 ! lipid tube assembly relationship: part_of GO:0048284 ! organelle fusion [Term] id: GO:0060990 name: lipid tube assembly involved in organelle fission namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "lipid tubulation involved in organelle fission" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060988 ! lipid tube assembly relationship: part_of GO:0048285 ! organelle fission [Term] id: GO:0060991 name: lipid tube assembly involved in cytokinesis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in cytokinesis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "lipid tubulation involved in cytokinesis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060988 ! lipid tube assembly relationship: part_of GO:0000919 ! cell plate assembly [Term] id: GO:0060992 name: response to fungicide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi." [GOC:dph] is_a: GO:0009636 ! response to toxin [Term] id: GO:0060993 name: kidney morphogenesis namespace: biological_process def: "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0060994 name: regulation of transcription from RNA polymerase II promoter involved in kidney development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the kidney progresses from its initial formation to the mature state." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0060995 name: cell-cell signaling involved in kidney development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in kidney development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0060996 name: dendritic spine development namespace: biological_process def: "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0016358 ! dendrite development [Term] id: GO:0060997 name: dendritic spine morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0032990 ! cell part morphogenesis is_a: GO:0097061 ! dendritic spine organization relationship: part_of GO:0048813 ! dendrite morphogenesis relationship: part_of GO:0060996 ! dendritic spine development [Term] id: GO:0060998 name: regulation of dendritic spine development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0050773 ! regulation of dendrite development relationship: regulates GO:0060996 ! dendritic spine development [Term] id: GO:0060999 name: positive regulation of dendritic spine development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0060998 ! regulation of dendritic spine development relationship: positively_regulates GO:0060996 ! dendritic spine development [Term] id: GO:0061000 name: negative regulation of dendritic spine development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0060998 ! regulation of dendritic spine development relationship: negatively_regulates GO:0060996 ! dendritic spine development [Term] id: GO:0061001 name: regulation of dendritic spine morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:0060998 ! regulation of dendritic spine development relationship: regulates GO:0060997 ! dendritic spine morphogenesis [Term] id: GO:0061002 name: negative regulation of dendritic spine morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0061000 ! negative regulation of dendritic spine development is_a: GO:0061001 ! regulation of dendritic spine morphogenesis relationship: negatively_regulates GO:0060997 ! dendritic spine morphogenesis [Term] id: GO:0061003 name: positive regulation of dendritic spine morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0060999 ! positive regulation of dendritic spine development is_a: GO:0061001 ! regulation of dendritic spine morphogenesis relationship: positively_regulates GO:0060997 ! dendritic spine morphogenesis [Term] id: GO:0061004 name: pattern specification involved in kidney development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "kidney pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "kidney pattern specification" EXACT [GOC:mtg_kidney_jan10] synonym: "pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072048 ! renal system pattern specification relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0061005 name: cell differentiation involved in kidney development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0061006 name: regulation of cell proliferation involved in kidney morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0060993 ! kidney morphogenesis [Term] id: GO:0061007 name: hepaticobiliary system process namespace: biological_process def: "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] synonym: "hepatobiliary system process" EXACT [GOC:dph] is_a: GO:0003008 ! system process [Term] id: GO:0061008 name: hepaticobiliary system development namespace: biological_process def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] synonym: "hepatobiliary system development" EXACT [GOC:dph] is_a: GO:0048731 ! system development [Term] id: GO:0061009 name: common bile duct development namespace: biological_process def: "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gall bladder. The common bile duct transports bile from the liver and gall bladder to the intestine." [PMID:20614624] synonym: "bile duct development" EXACT [GOC:dph] synonym: "CBD development" EXACT [PMID:20614624] synonym: "EHBD development" BROAD [PMID:20614624] synonym: "extrahepatic bile duct development" BROAD [PMID:20614624] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061008 ! hepaticobiliary system development [Term] id: GO:0061010 name: gall bladder development namespace: biological_process def: "The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile." [GOC:dph] is_a: GO:0048513 ! organ development relationship: part_of GO:0061008 ! hepaticobiliary system development [Term] id: GO:0061011 name: hepatic duct development namespace: biological_process def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct." [GOC:dph, PMID:20614624] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061008 ! hepaticobiliary system development [Term] id: GO:0061013 name: regulation of mRNA catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0006402 ! mRNA catabolic process [Term] id: GO:0061014 name: positive regulation of mRNA catabolic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "positive regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:0061013 ! regulation of mRNA catabolic process relationship: positively_regulates GO:0006402 ! mRNA catabolic process [Term] id: GO:0061015 name: snRNA import into nucleus namespace: biological_process def: "The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006404 ! RNA import into nucleus is_a: GO:0051030 ! snRNA transport [Term] id: GO:0061016 name: snRNA import into Cajal body namespace: biological_process def: "The directed movement of snRNA, small nuclear ribonucleic acid, into a Cajal body." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051030 ! snRNA transport [Term] id: GO:0061017 name: hepatoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394] is_a: GO:0048863 ! stem cell differentiation relationship: part_of GO:0001889 ! liver development [Term] id: GO:0061024 name: membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_generic is_a: GO:0016043 ! cellular component organization [Term] id: GO:0061025 name: membrane fusion namespace: biological_process def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] is_a: GO:0061024 ! membrane organization [Term] id: GO:0061026 name: cardiac muscle tissue regeneration namespace: biological_process def: "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:dph] is_a: GO:0042246 ! tissue regeneration [Term] id: GO:0061027 name: umbilical cord development namespace: biological_process def: "The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:dph] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0061028 name: establishment of endothelial barrier namespace: biological_process def: "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:dph] is_a: GO:0001885 ! endothelial cell development [Term] id: GO:0061029 name: eyelid development in camera-type eye namespace: biological_process def: "The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0061030 name: epithelial cell differentiation involved in mammary gland alveolus development namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus." [GOC:dph] is_a: GO:0060644 ! mammary gland epithelial cell differentiation relationship: part_of GO:0060749 ! mammary gland alveolus development [Term] id: GO:0061031 name: endodermal digestive tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm." [GOC:dph] is_a: GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0061032 name: visceral serous pericardium development namespace: biological_process def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph] synonym: "epicardium development" EXACT [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060039 ! pericardium development [Term] id: GO:0061033 name: secretion by lung epithelial cell involved in lung growth namespace: biological_process def: "The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development." [GOC:dph] synonym: "fetal lung liquid secretion" RELATED [GOC:dph] is_a: GO:0032940 ! secretion by cell relationship: part_of GO:0060437 ! lung growth [Term] id: GO:0061034 name: olfactory bulb mitral cell layer development namespace: biological_process def: "The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021772 ! olfactory bulb development [Term] id: GO:0061035 name: regulation of cartilage development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0051216 ! cartilage development [Term] id: GO:0061036 name: positive regulation of cartilage development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0061035 ! regulation of cartilage development relationship: positively_regulates GO:0051216 ! cartilage development [Term] id: GO:0061037 name: negative regulation of cartilage development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0061035 ! regulation of cartilage development relationship: negatively_regulates GO:0051216 ! cartilage development [Term] id: GO:0061038 name: uterus morphogenesis namespace: biological_process def: "The process in which anatomical structures of the uterus are generated and organized." [GOC:BHF, GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0060065 ! uterus development [Term] id: GO:0061039 name: ovum-producing ovary development namespace: biological_process def: "The process whose specific outcome is the progression of an ovary that produces an ovum over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0008585 ! female gonad development [Term] id: GO:0061040 name: ovum-producing ovary morphogenesis namespace: biological_process def: "The process in which an ovum-producing ovary is generated and organized." [GOC:BHF, GOC:dph] is_a: GO:0035262 ! gonad morphogenesis relationship: part_of GO:0061039 ! ovum-producing ovary development [Term] id: GO:0061041 name: regulation of wound healing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph] is_a: GO:0080134 ! regulation of response to stress relationship: regulates GO:0042060 ! wound healing [Term] id: GO:0061042 name: vascular wound healing namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph] is_a: GO:0060055 ! angiogenesis involved in wound healing [Term] id: GO:0061043 name: regulation of vascular wound healing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:dph] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0061041 ! regulation of wound healing relationship: regulates GO:0061042 ! vascular wound healing [Term] id: GO:0061044 name: negative regulation of vascular wound healing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph] is_a: GO:0016525 ! negative regulation of angiogenesis is_a: GO:0061043 ! regulation of vascular wound healing is_a: GO:0061045 ! negative regulation of wound healing relationship: negatively_regulates GO:0061042 ! vascular wound healing [Term] id: GO:0061045 name: negative regulation of wound healing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0061041 ! regulation of wound healing relationship: negatively_regulates GO:0042060 ! wound healing [Term] id: GO:0061046 name: regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0061047 name: positive regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis relationship: positively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0061048 name: negative regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis relationship: negatively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0061049 name: cell growth involved in cardiac muscle cell development namespace: biological_process def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph] synonym: "cardiomyocyte growth" RELATED [GOC:dph] synonym: "heart muscle cell growth" RELATED [GOD:dph] is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0003301 ! physiological cardiac muscle hypertrophy relationship: part_of GO:0055013 ! cardiac muscle cell development [Term] id: GO:0061050 name: regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development [Term] id: GO:0061051 name: positive regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development relationship: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development [Term] id: GO:0061052 name: negative regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development relationship: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development [Term] id: GO:0061053 name: somite development namespace: biological_process def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0061054 name: dermatome development namespace: biological_process def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061053 ! somite development [Term] id: GO:0061055 name: myotome development namespace: biological_process def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061053 ! somite development [Term] id: GO:0061056 name: sclerotome development namespace: biological_process def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061053 ! somite development [Term] id: GO:0061057 name: peptidoglycan recognition protein signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and mediated by Imd. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] synonym: "Imd signaling pathway" EXACT [GOC:dph] synonym: "Imd signalling pathway" EXACT [GOC:dph] synonym: "immune deficiency pathway" RELATED [GOC:dph] synonym: "immune deficiency signaling pathway" RELATED [GOC:dph] synonym: "PGRP signaling pathway" RELATED [GOC:dph] is_a: GO:0007166 ! cell surface receptor linked signaling pathway relationship: part_of GO:0042742 ! defense response to bacterium [Term] id: GO:0061058 name: regulation of peptidoglycan recognition protein signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] synonym: "regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0031347 ! regulation of defense response is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway [Term] id: GO:0061059 name: positive regulation of peptidoglycan recognition protein signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] synonym: "positive regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway relationship: positively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway [Term] id: GO:0061060 name: negative regulation of peptidoglycan recognition protein signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] synonym: "negative regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway relationship: negatively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway [Term] id: GO:0061061 name: muscle structure development namespace: biological_process def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0061062 name: regulation of nematode larval development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] is_a: GO:0048580 ! regulation of post-embryonic development relationship: regulates GO:0002119 ! nematode larval development [Term] id: GO:0061063 name: positive regulation of nematode larval development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0061062 ! regulation of nematode larval development relationship: positively_regulates GO:0002119 ! nematode larval development [Term] id: GO:0061064 name: negative regulation of nematode larval development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0061062 ! regulation of nematode larval development relationship: negatively_regulates GO:0002119 ! nematode larval development [Term] id: GO:0061065 name: regulation of dauer larval development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv] is_a: GO:0061062 ! regulation of nematode larval development relationship: regulates GO:0040024 ! dauer larval development [Term] id: GO:0061066 name: positive regulation of dauer larval development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv] is_a: GO:0061063 ! positive regulation of nematode larval development is_a: GO:0061065 ! regulation of dauer larval development relationship: positively_regulates GO:0040024 ! dauer larval development [Term] id: GO:0061067 name: negative regulation of dauer larval development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv] is_a: GO:0061064 ! negative regulation of nematode larval development is_a: GO:0061065 ! regulation of dauer larval development relationship: negatively_regulates GO:0040024 ! dauer larval development [Term] id: GO:0061068 name: urethra development namespace: biological_process def: "The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body." [GOC:dph] is_a: GO:0048513 ! organ development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0061069 name: male urethra development namespace: biological_process def: "The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body." [GOC:dph] is_a: GO:0061068 ! urethra development [Term] id: GO:0061070 name: female urethra development namespace: biological_process def: "The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening." [GOC:dph] is_a: GO:0061068 ! urethra development [Term] id: GO:0061071 name: urethra epithelium development namespace: biological_process def: "The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes." [GOC:dph] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0061068 ! urethra development [Term] id: GO:0061072 name: iris morphogenesis namespace: biological_process def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0061073 name: ciliary body morphogenesis namespace: biological_process def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0061074 name: regulation of neural retina development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0003407 ! neural retina development [Term] id: GO:0061075 name: positive regulation of neural retina development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0061074 ! regulation of neural retina development relationship: positively_regulates GO:0003407 ! neural retina development [Term] id: GO:0061076 name: negative regulation of neural retina development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0061074 ! regulation of neural retina development relationship: negatively_regulates GO:0003407 ! neural retina development [Term] id: GO:0061077 name: chaperone-mediated protein folding namespace: biological_process def: "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] is_a: GO:0006457 ! protein folding [Term] id: GO:0061078 name: positive regulation of prostaglandin secretion involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells and contributes to the immune response." [GOC:BHF, GOC:dph] synonym: "positive regulation of prostaglandin secretion during immune response " RELATED [GOC:dph] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0032308 ! positive regulation of prostaglandin secretion is_a: GO:0050776 ! regulation of immune response relationship: positively_regulates GO:0090323 ! prostaglandin secretion involved in immune response [Term] id: GO:0061079 name: left horn of sinus venosus development namespace: biological_process def: "The progression of the left horn of the sinus venosus from its initial formation to the mature structure." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003235 ! sinus venosus development [Term] id: GO:0061080 name: right horn of sinus venosus development namespace: biological_process def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003235 ! sinus venosus development [Term] id: GO:0061081 name: positive regulation of myeloid leukocyte cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response." [GOC:BHF, GOC:dph] synonym: "positive regulation of myeloid cell cytokine production involved in immune response" RELATED [GOC:dph] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response relationship: positively_regulates GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0061082 name: myeloid leukocyte cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid cell." [GOC:dph] is_a: GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0061083 name: regulation of protein refolding namespace: biological_process def: "Any process that regulates the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:dph, GOC:tb] is_a: GO:0032268 ! regulation of cellular protein metabolic process relationship: regulates GO:0042026 ! protein refolding [Term] id: GO:0061084 name: negative regulation of protein refolding namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032269 ! negative regulation of cellular protein metabolic process is_a: GO:0061083 ! regulation of protein refolding relationship: negatively_regulates GO:0042026 ! protein refolding [Term] id: GO:0061085 name: regulation of histone H3-K27 methylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] is_a: GO:0031060 ! regulation of histone methylation relationship: regulates GO:0070734 ! histone H3-K27 methylation [Term] id: GO:0061086 name: negative regulation of histone H3-K27 methylation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] is_a: GO:0031061 ! negative regulation of histone methylation is_a: GO:0061085 ! regulation of histone H3-K27 methylation relationship: negatively_regulates GO:0070734 ! histone H3-K27 methylation [Term] id: GO:0061087 name: positive regulation of histone H3-K27 methylation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] is_a: GO:0031062 ! positive regulation of histone methylation is_a: GO:0061085 ! regulation of histone H3-K27 methylation relationship: positively_regulates GO:0070734 ! histone H3-K27 methylation [Term] id: GO:0061088 name: regulation of sequestering of zinc ion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process is_a: GO:2000021 ! regulation of ion homeostasis relationship: regulates GO:0032119 ! sequestering of zinc ion [Term] id: GO:0061089 name: negative regulation of sequestering of zinc ion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0061088 ! regulation of sequestering of zinc ion relationship: negatively_regulates GO:0032119 ! sequestering of zinc ion [Term] id: GO:0061090 name: positive regulation of sequestering of zinc ion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0061088 ! regulation of sequestering of zinc ion relationship: positively_regulates GO:0032119 ! sequestering of zinc ion [Term] id: GO:0061091 name: regulation of phospholipid translocation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0045332 ! phospholipid translocation [Term] id: GO:0061092 name: positive regulation of phospholipid translocation namespace: biological_process def: "Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0061091 ! regulation of phospholipid translocation relationship: positively_regulates GO:0045332 ! phospholipid translocation [Term] id: GO:0061093 name: negative regulation of phospholipid translocation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0061091 ! regulation of phospholipid translocation relationship: negatively_regulates GO:0045332 ! phospholipid translocation [Term] id: GO:0061094 name: regulation of turning behavior involved in mating namespace: biological_process def: "Any process that modulates the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0050795 ! regulation of behavior is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0034607 ! turning behavior involved in mating [Term] id: GO:0061095 name: positive regulation of turning behavior involved in mating namespace: biological_process def: "Any process that increases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb] is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061094 ! regulation of turning behavior involved in mating is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0034607 ! turning behavior involved in mating [Term] id: GO:0061096 name: negative regulation of turning behavior involved in mating namespace: biological_process def: "Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb] is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061094 ! regulation of turning behavior involved in mating is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0034607 ! turning behavior involved in mating [Term] id: GO:0061097 name: regulation of protein tyrosine kinase activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] is_a: GO:0045859 ! regulation of protein kinase activity [Term] id: GO:0061098 name: positive regulation of protein tyrosine kinase activity namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:0061097 ! regulation of protein tyrosine kinase activity [Term] id: GO:0061099 name: negative regulation of protein tyrosine kinase activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0061097 ! regulation of protein tyrosine kinase activity [Term] id: GO:0061100 name: lung neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746] is_a: GO:0060487 ! lung epithelial cell differentiation is_a: GO:0061101 ! neuroendocrine cell differentiation [Term] id: GO:0061101 name: neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0061102 name: stomach neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium." [GOC:dph, PMID:18173746] synonym: "gastric neuroendocrine cell differentiation" RELATED [GOC:dph] is_a: GO:0061101 ! neuroendocrine cell differentiation relationship: part_of GO:0048513 ! organ development relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0061103 name: carotid body glomus cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia." [GOC:dph, PMID:6243386] is_a: GO:0061101 ! neuroendocrine cell differentiation relationship: part_of GO:0048513 ! organ development [Term] id: GO:0061104 name: adrenal chromaffin cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles." [GOC:dph] is_a: GO:0061101 ! neuroendocrine cell differentiation relationship: part_of GO:0030325 ! adrenal gland development [Term] id: GO:0061105 name: regulation of stomach neuroendocrine cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0061102 ! stomach neuroendocrine cell differentiation [Term] id: GO:0061106 name: negative regulation of stomach neuroendocrine cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0061105 ! regulation of stomach neuroendocrine cell differentiation relationship: negatively_regulates GO:0061102 ! stomach neuroendocrine cell differentiation [Term] id: GO:0061107 name: seminal vesicle development namespace: biological_process def: "The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen." [GOC:dph] is_a: GO:0048608 ! reproductive structure development is_a: GO:0048732 ! gland development [Term] id: GO:0061108 name: seminal vesicle epithelium development namespace: biological_process def: "The progression of the seminal vesicle epithelium over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060429 ! epithelium development relationship: part_of GO:0061107 ! seminal vesicle development [Term] id: GO:0061109 name: dense core granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph] is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0061110 name: dense core granule biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a dense core granule. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the dense core granule." [GOC:dph] is_a: GO:0071843 ! cellular component biogenesis at cellular level [Term] id: GO:0061111 name: epithelial-mesenchymal cell signaling involved in lung development namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060684 ! epithelial-mesenchymal cell signaling [Term] id: GO:0061112 name: negative regulation of bud outgrowth involved in lung branching namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of bud outgrowth involved in lung branching." [GOC:dph] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0061048 ! negative regulation of branching involved in lung morphogenesis relationship: negatively_regulates GO:0060447 ! bud outgrowth involved in lung branching [Term] id: GO:0061113 name: pancreas morphogenesis namespace: biological_process def: "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized." [GOC:dph] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0031016 ! pancreas development [Term] id: GO:0061114 name: branching involved in pancreas morphogenesis namespace: biological_process def: "The process in which the branches of the pancreas are generated and organized." [GOC:dph] is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0061113 ! pancreas morphogenesis [Term] id: GO:0061115 name: lung proximal/distal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the lung. The proximal/distal axis of the lung is defined by a line that runs from the trachea to the alveoli." [GOC:dph] is_a: GO:0009946 ! proximal/distal axis specification is_a: GO:0060432 ! lung pattern specification process [Term] id: GO:0061116 name: ductus venosus closure namespace: biological_process def: "The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth." [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis [Term] id: GO:0061117 name: negative regulation of heart growth namespace: biological_process def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd] is_a: GO:0046621 ! negative regulation of organ growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0060420 ! regulation of heart growth relationship: negatively_regulates GO:0060419 ! heart growth [Term] id: GO:0061118 name: regulation of positive chemotaxis to cAMP namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph] is_a: GO:0050926 ! regulation of positive chemotaxis relationship: regulates GO:0043327 ! chemotaxis to cAMP [Term] id: GO:0061119 name: regulation of positive chemotaxis to cAMP by chlorinated alkylphenone namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph, PMID:19684855] is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP [Term] id: GO:0061120 name: regulation of positive chemotaxis to cAMP by DIF-1 namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone [Term] id: GO:0061121 name: regulation of positive chemotaxis to cAMP by DIF-2 namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone [Term] id: GO:0061122 name: positive regulation of positive chemotaxis to cAMP namespace: biological_process def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph] is_a: GO:0050927 ! positive regulation of positive chemotaxis is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP relationship: positively_regulates GO:0043327 ! chemotaxis to cAMP [Term] id: GO:0061123 name: negative regulation of positive chemotaxis to cAMP namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph] is_a: GO:0050928 ! negative regulation of positive chemotaxis is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP relationship: negatively_regulates GO:0043327 ! chemotaxis to cAMP [Term] id: GO:0061124 name: positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone namespace: biological_process def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph] is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone is_a: GO:0061122 ! positive regulation of positive chemotaxis to cAMP [Term] id: GO:0061125 name: negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph] is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone is_a: GO:0061123 ! negative regulation of positive chemotaxis to cAMP [Term] id: GO:0061126 name: positive regulation of positive chemotaxis to cAMP by DIF-1 namespace: biological_process def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1 is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone [Term] id: GO:0061127 name: negative regulation of positive chemotaxis to cAMP by DIF-1 namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1 is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone [Term] id: GO:0061128 name: positive regulation of chemotaxis to cAMP by DIF-2 namespace: biological_process def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2 is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone [Term] id: GO:0061129 name: negative regulation of positive chemotaxis to cAMP by DIF-2 namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2 is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone [Term] id: GO:0061130 name: pancreatic bud formation namespace: biological_process def: "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud." [GOC:dph] is_a: GO:0048645 ! organ formation is_a: GO:0061114 ! branching involved in pancreas morphogenesis [Term] id: GO:0061131 name: pancreas field specification namespace: biological_process def: "The process in which a specific region of the gut is delineated into the area in which the pancreas will develop." [GOC:dph] is_a: GO:0010092 ! specification of organ identity relationship: part_of GO:0061130 ! pancreatic bud formation [Term] id: GO:0061132 name: pancreas induction namespace: biological_process def: "The close range interaction of two or more cells or tissues that causes the cells of the gut to change their fates and specify the development of the pancreas." [GOC:dph] is_a: GO:0001759 ! organ induction is_a: GO:0060688 ! regulation of morphogenesis of a branching structure relationship: positively_regulates GO:0061131 ! pancreas field specification [Term] id: GO:0061133 name: endopeptidase activator activity namespace: molecular_function def: "Increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:dph, GOC:tb] is_a: GO:0016504 ! peptidase activator activity is_a: GO:0061135 ! endopeptidase regulator activity [Term] id: GO:0061134 name: peptidase regulator activity namespace: molecular_function def: "Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0061135 name: endopeptidase regulator activity namespace: molecular_function def: "Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:dph, GOC:tb] is_a: GO:0061134 ! peptidase regulator activity [Term] id: GO:0061136 name: regulation of proteasomal protein catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process relationship: regulates GO:0010498 ! proteasomal protein catabolic process [Term] id: GO:0061137 name: bud dilation namespace: biological_process def: "The process in which a branch bud increases radially. A branch bud is the initial area of outgrowth in the formation of a new branch." [GOC:dph] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0001763 ! morphogenesis of a branching structure [Term] id: GO:0061138 name: morphogenesis of a branching epithelium namespace: biological_process def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph] is_a: GO:0001763 ! morphogenesis of a branching structure is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0061139 name: bud field specification namespace: biological_process def: "The regionalization process in which the identity of a bud primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph] is_a: GO:0003002 ! regionalization relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium [Term] id: GO:0061140 name: lung secretory cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph] is_a: GO:0060487 ! lung epithelial cell differentiation [Term] id: GO:0061141 name: lung ciliated cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains a motile cilium for moving substances released from lung secretory cells." [GOC:dph] is_a: GO:0060487 ! lung epithelial cell differentiation [Term] id: GO:0061142 name: mesothelial-mesenchymal cell signaling involved in early lung development namespace: biological_process def: "Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung." [GOC:dph] synonym: "mesothelial-mesenchymal cell signalling involved in early lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development [Term] id: GO:0061143 name: alveolar primary septum development namespace: biological_process def: "The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms." [GOC:dph] is_a: GO:0060428 ! lung epithelium development relationship: part_of GO:0060430 ! lung saccule development [Term] id: GO:0061144 name: alveolar secondary septum development namespace: biological_process def: "The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule." [GOC:dph] is_a: GO:0060428 ! lung epithelium development relationship: part_of GO:0060430 ! lung saccule development [Term] id: GO:0061145 name: lung smooth muscle development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0048745 ! smooth muscle tissue development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0061146 name: Peyer's patch morphogenesis namespace: biological_process def: "The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048541 ! Peyer's patch development [Term] id: GO:0061147 name: endocardial endothelium development namespace: biological_process def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] is_a: GO:0003158 ! endothelium development relationship: part_of GO:0003157 ! endocardium development [Term] id: GO:0061148 name: extracellular matrix organization involved in endocardium development namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] is_a: GO:0030198 ! extracellular matrix organization relationship: part_of GO:0003157 ! endocardium development [Term] id: GO:0061149 name: BMP signaling pathway involved in ureter morphogenesis namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "BMP signalling pathway involved in ureter morphogenesis" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0072197 ! ureter morphogenesis [Term] id: GO:0061150 name: renal system segmentation namespace: biological_process def: "The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis." [GOC:dph] synonym: "urinary tract segmentation" EXACT [GOC:dph] is_a: GO:0035282 ! segmentation is_a: GO:0072048 ! renal system pattern specification [Term] id: GO:0061151 name: BMP signaling pathway involved in renal system segmentation namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the segmentation of the renal system." [GOC:dph] synonym: "BMP signalling pathway involved in renal system segmentation" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0061150 ! renal system segmentation [Term] id: GO:0061152 name: trachea submucosa development namespace: biological_process def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060438 ! trachea development [Term] id: GO:0061153 name: trachea gland development namespace: biological_process def: "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection." [GOC:dph] is_a: GO:0048732 ! gland development relationship: part_of GO:0061152 ! trachea submucosa development [Term] id: GO:0061154 name: endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. An endothelium is an epithelium that lines an anatomical structure." [GOC:dph] is_a: GO:0003159 ! morphogenesis of an endothelium is_a: GO:0060562 ! epithelial tube morphogenesis [Term] id: GO:0061155 name: pulmonary artery endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph] is_a: GO:0061154 ! endothelial tube morphogenesis relationship: part_of GO:0061156 ! pulmonary artery morphogenesis [Term] id: GO:0061156 name: pulmonary artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph] is_a: GO:0048844 ! artery morphogenesis [Term] id: GO:0061157 name: mRNA destabilization namespace: biological_process def: "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh] is_a: GO:0050779 ! RNA destabilization [Term] id: GO:0061158 name: 3'-UTR-mediated mRNA destabilization namespace: biological_process def: "An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:dph, GOC:jh] is_a: GO:0061157 ! mRNA destabilization [Term] id: GO:0061159 name: establishment of bipolar cell polarity involved in cell morphogenesis namespace: biological_process def: "The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw] is_a: GO:0061171 ! establishment of bipolar cell polarity relationship: part_of GO:0000902 ! cell morphogenesis [Term] id: GO:0061160 name: regulation of establishment of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell." [GOC:dph, GOC:vw] is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape [Term] id: GO:0061161 name: positive regulation of establishment of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell." [GOC:dph, GOC:vw] is_a: GO:0061160 ! regulation of establishment of bipolar cell polarity regulating cell shape is_a: GO:0061173 ! positive regulation of establishment of bipolar cell polarity is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape [Term] id: GO:0061162 name: establishment of monopolar cell polarity namespace: biological_process def: "The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity [Term] id: GO:0061163 name: endoplasmic reticulum polarization namespace: biological_process def: "The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell." [GOC:dph, GOC:vw] is_a: GO:0007029 ! endoplasmic reticulum organization is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0061164 name: transitional endoplasmic reticulum polarization at cell division site namespace: biological_process def: "The endoplasmic reticulum polarization process that results in the structure being polarized at the site of future cell division." [GOC:dph, GOC:vw] is_a: GO:0061163 ! endoplasmic reticulum polarization [Term] id: GO:0061165 name: endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site namespace: biological_process def: "The process in which endoplasmic reticulum is transiently localized to the site where a cell will divide." [GOC:dph, GOC:vw] synonym: "endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" EXACT [GOC:mah] synonym: "ER localization involved in ER polarization at cell division site" EXACT [GOC:dph] is_a: GO:0051643 ! endoplasmic reticulum localization relationship: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site [Term] id: GO:0061166 name: establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site namespace: biological_process def: "The directed movement of the endoplasmic reticulum to the site where a cell will divide." [GOC:dph, GOC:vw] synonym: "establishment of endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" EXACT [GOC:mah] is_a: GO:0051686 ! establishment of ER localization relationship: part_of GO:0061165 ! endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site [Term] id: GO:0061167 name: maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site namespace: biological_process def: "The process in which the endoplasmic reticulum is maintained at the site of cell division and is prevented from moving elsewhere." [GOC:dph, GOC:vw] is_a: GO:0051685 ! maintenance of ER location relationship: part_of GO:0061165 ! endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site [Term] id: GO:0061168 name: regulation of hair follicle placode formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051797 ! regulation of hair follicle development relationship: regulates GO:0060789 ! hair follicle placode formation [Term] id: GO:0061169 name: positive regulation of hair placode formation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0061168 ! regulation of hair follicle placode formation relationship: positively_regulates GO:0060789 ! hair follicle placode formation [Term] id: GO:0061170 name: negative regulation of hair follicle placode formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0061168 ! regulation of hair follicle placode formation relationship: negatively_regulates GO:0060789 ! hair follicle placode formation [Term] id: GO:0061171 name: establishment of bipolar cell polarity namespace: biological_process def: "The specification and formation of bipolar intracellular organization or cell growth patterns. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw] is_a: GO:0030010 ! establishment of cell polarity [Term] id: GO:0061172 name: regulation of establishment of bipolar cell polarity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw] is_a: GO:2000114 ! regulation of establishment of cell polarity relationship: regulates GO:0061171 ! establishment of bipolar cell polarity [Term] id: GO:0061173 name: positive regulation of establishment of bipolar cell polarity namespace: biological_process def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity." [GOC:dph, GOC:vw] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity relationship: positively_regulates GO:0061171 ! establishment of bipolar cell polarity [Term] id: GO:0061174 name: type I terminal button namespace: cellular_component def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph] synonym: "type I terminal bouton" EXACT [GOC:dph] is_a: GO:0043195 ! terminal button [Term] id: GO:0061175 name: type II terminal button namespace: cellular_component def: "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph] synonym: "type II terminal bouton" EXACT [GOC:dph] is_a: GO:0043195 ! terminal button [Term] id: GO:0061176 name: type Ib terminal button namespace: cellular_component def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal buttons are larger than type Is terminal buttons." [GOC:dph] synonym: "type Ib terminal bouton" EXACT [GOC:dph] is_a: GO:0061174 ! type I terminal button [Term] id: GO:0061177 name: type Is terminal button namespace: cellular_component def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal buttons are smaller than type Ib terminal buttons." [GOC:dph] synonym: "type Is terminal bouton" RELATED [GOC:dph] is_a: GO:0061174 ! type I terminal button [Term] id: GO:0061178 name: regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] synonym: "regulation of insulin secretion in response to glucose" EXACT [GOC:dph] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050796 ! regulation of insulin secretion relationship: regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus [Term] id: GO:0061179 name: negative regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] synonym: "negative regulation of insulin secretion in response to glucose " RELATED [GOC:dph] synonym: "negative regulation of insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] is_a: GO:0046676 ! negative regulation of insulin secretion is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus relationship: negatively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus [Term] id: GO:0061180 name: mammary gland epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph] synonym: "breast epithelium development" EXACT [GOC:dph] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0061181 name: regulation of chondrocyte development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0002063 ! chondrocyte development [Term] id: GO:0061182 name: negative regulation of chondrocyte development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0061181 ! regulation of chondrocyte development relationship: negatively_regulates GO:0002063 ! chondrocyte development [Term] id: GO:0061183 name: regulation of dermatome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0061054 ! dermatome development [Term] id: GO:0061184 name: positive regulation of dermatome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development relationship: positively_regulates GO:0061054 ! dermatome development [Term] id: GO:0061185 name: negative regulation of dermatome development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development relationship: negatively_regulates GO:0061054 ! dermatome development [Term] id: GO:0061186 name: negative regulation of chromatin silencing at silent mating-type cassette namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, PMID:10388812] is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0090054 ! regulation of chromatin silencing at silent mating-type cassette relationship: negatively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette [Term] id: GO:0061187 name: regulation of chromatin silencing at rDNA namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin." [GOC:dph, PMID:10388812] is_a: GO:0031935 ! regulation of chromatin silencing relationship: regulates GO:0000183 ! chromatin silencing at rDNA [Term] id: GO:0061188 name: negative regulation of chromatin silencing at rDNA namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin." [GOC:dph, PMID:10388812] is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0061187 ! regulation of chromatin silencing at rDNA relationship: negatively_regulates GO:0000183 ! chromatin silencing at rDNA [Term] id: GO:0061189 name: positive regulation of sclerotome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0061190 ! regulation of sclerotome development relationship: positively_regulates GO:0061056 ! sclerotome development [Term] id: GO:0061190 name: regulation of sclerotome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0061056 ! sclerotome development [Term] id: GO:0061191 name: positive regulation of vacuole fusion, non-autophagic namespace: biological_process def: "Any process that increases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph] is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic is_a: GO:0044090 ! positive regulation of vacuole organization relationship: positively_regulates GO:0042144 ! vacuole fusion, non-autophagic [Term] id: GO:0061192 name: negative regulation of vacuole fusion, non-autophagic namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic relationship: negatively_regulates GO:0042144 ! vacuole fusion, non-autophagic [Term] id: GO:0061193 name: taste bud development namespace: biological_process def: "The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043586 ! tongue development [Term] id: GO:0061194 name: taste bud morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0043587 ! tongue morphogenesis relationship: part_of GO:0061193 ! taste bud development [Term] id: GO:0061195 name: taste bud formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0061194 ! taste bud morphogenesis [Term] id: GO:0061196 name: fungiform papilla development namespace: biological_process def: "The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043586 ! tongue development [Term] id: GO:0061197 name: fungiform papilla morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0043587 ! tongue morphogenesis relationship: part_of GO:0061196 ! fungiform papilla development [Term] id: GO:0061198 name: fungiform papilla formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0061197 ! fungiform papilla morphogenesis [Term] id: GO:0061199 name: striated muscle contraction involved in embryonic body morphogenesis namespace: biological_process def: "The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology." [GOC:dph, GOC:kmv] is_a: GO:0006941 ! striated muscle contraction relationship: part_of GO:0010172 ! embryonic body morphogenesis [Term] id: GO:0061200 name: clathrin sculpted gamma-aminobutyric acid transport vesicle namespace: cellular_component def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle." [GOC:dph] synonym: "clathrin sculpted GABA transport vesicle" EXACT [GOC:dph] is_a: GO:0060198 ! clathrin sculpted vesicle [Term] id: GO:0061201 name: clathrin sculpted gamma-aminobutyric acid transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph] synonym: "clathrin sculpted GABA transport vesicle lumen" EXACT [GOC:dph] is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0061200 ! clathrin sculpted gamma-aminobutyric acid transport vesicle [Term] id: GO:0061202 name: clathrin sculpted gamma-aminobutyric acid transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph] synonym: "clathrin sculpted GABA transport vesicle membrane" EXACT [GOC:dph] is_a: GO:0030665 ! clathrin coated vesicle membrane relationship: part_of GO:0061200 ! clathrin sculpted gamma-aminobutyric acid transport vesicle [Term] id: GO:0061203 name: striated muscle paramyosin thick filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the paramyosin-based thick filaments of myofibrils in striated muscle." [GOC:dph, GOC:kmv] is_a: GO:0061204 ! paramyosin filament assembly or disassembly relationship: part_of GO:0030239 ! myofibril assembly [Term] id: GO:0061204 name: paramyosin filament assembly or disassembly namespace: biological_process def: "The formation or disassembly of a filament composed of paramyosin molecules." [GOC:dph, GOC:kmv] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0061205 name: paramesonephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin." [GOC:dph] synonym: "Mullerian duct development" EXACT [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0061206 name: mesonephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephros are generated and organized." [GOC:mtg_kidney_jan10] is_a: GO:0060993 ! kidney morphogenesis relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061207 name: mesonephric juxtaglomerulus cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072052 ! juxtaglomerulus cell differentiation relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development [Term] id: GO:0061208 name: cell differentiation involved in mesonephros development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061209 name: cell proliferation involved in mesonephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061210 name: cell-cell signaling involved in mesonephros development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in mesonephros development" EXACT [GOC:mah] is_a: GO:0060995 ! cell-cell signaling involved in kidney development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061211 name: mesonephric collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061212 name: mesonephric juxtaglomerular apparatus development namespace: biological_process def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10] is_a: GO:0072051 ! juxtaglomerular apparatus development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061213 name: positive regulation of mesonephros development namespace: biological_process def: "Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0090184 ! positive regulation of kidney development relationship: positively_regulates GO:0001823 ! mesonephros development [Term] id: GO:0061214 name: mesonephric smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072194 ! kidney smooth muscle tissue development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061215 name: mesonephric nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061216 name: regulation of transcription from RNA polymerase II promoter involved in mesonephros development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the mesonephros progressing from its initial formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061217 name: regulation of mesonephros development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0090183 ! regulation of kidney development relationship: regulates GO:0001823 ! mesonephros development [Term] id: GO:0061218 name: negative regulation of mesonephros development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0090185 ! negative regulation of kidney development relationship: negatively_regulates GO:0001823 ! mesonephros development [Term] id: GO:0061219 name: mesonephric mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061220 name: mesonephric macula densa development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072024 ! macula densa development relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development [Term] id: GO:0061221 name: mesonephric mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072131 ! kidney mesenchyme morphogenesis relationship: part_of GO:0061219 ! mesonephric mesenchyme development [Term] id: GO:0061222 name: mesonephric mesenchymal cell proliferation involved in mesonephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesonephric mesenchymal cell population." [GOC:mtg_kidney_jan10] is_a: GO:0061209 ! cell proliferation involved in mesonephros development is_a: GO:0072135 ! kidney mesenchymal cell proliferation relationship: part_of GO:0061219 ! mesonephric mesenchyme development [Term] id: GO:0061223 name: mesonephric mesenchymal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development relationship: part_of GO:0061219 ! mesonephric mesenchyme development [Term] id: GO:0061224 name: mesonephric glomerulus development namespace: biological_process def: "The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0032835 ! glomerulus development relationship: part_of GO:0061215 ! mesonephric nephron development [Term] id: GO:0061225 name: mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development namespace: biological_process def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10] synonym: "mesonephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "mesonephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061209 ! cell proliferation involved in mesonephros development is_a: GO:0072122 ! extraglomerular mesangial cell proliferation relationship: part_of GO:0061215 ! mesonephric nephron development [Term] id: GO:0061226 name: proximal/distal pattern formation involved in mesonephric nephron development namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the mesonephros. The proximal/distal axis is defined by a line that runs from the glomerulus (proximal end) outward toward the mesonephric duct (distal end)." [GOC:mtg_kidney_jan10] is_a: GO:0061227 ! pattern specification involved in mesonephros development is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development relationship: part_of GO:0061215 ! mesonephric nephron development [Term] id: GO:0061227 name: pattern specification involved in mesonephros development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "mesonephros pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "mesonephros pattern specification" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061228 name: mesonephric nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072028 ! nephron morphogenesis relationship: part_of GO:0061206 ! mesonephros morphogenesis relationship: part_of GO:0061215 ! mesonephric nephron development [Term] id: GO:0061229 name: mesonephric juxtaglomerulus cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072142 ! juxtaglomerulus cell development relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation [Term] id: GO:0061230 name: mesonephric juxtaglomerulus cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10] is_a: GO:0072150 ! juxtaglomerulus cell fate commitment relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation [Term] id: GO:0061231 name: mesonephric glomerulus vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072012 ! glomerulus vasculature development relationship: part_of GO:0061224 ! mesonephric glomerulus development [Term] id: GO:0061232 name: mesonephric glomerular epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \\\"feet\\\" that interdigitate with the \\\"feet\\\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072010 ! glomerular epithelium development is_a: GO:0072163 ! mesonephric epithelium development relationship: part_of GO:0061224 ! mesonephric glomerulus development [Term] id: GO:0061233 name: mesonephric glomerular basement membrane development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric glomerular basement membrane over time, from its formation to the mature structure. The mesonephric glomerular basement membrane is the basal laminal portion of the mesonephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10] is_a: GO:0032836 ! glomerular basement membrane development relationship: part_of GO:0061224 ! mesonephric glomerulus development [Term] id: GO:0061234 name: mesonephric glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072102 ! glomerulus morphogenesis relationship: part_of GO:0061224 ! mesonephric glomerulus development relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis [Term] id: GO:0061235 name: mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis namespace: biological_process def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis [Term] id: GO:0061236 name: mesonephric comma-shaped body morphogenesis namespace: biological_process def: "The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072049 ! comma-shaped body morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis [Term] id: GO:0061237 name: convergent extension involved in mesonephric nephron morphogenesis namespace: biological_process def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis [Term] id: GO:0061238 name: establishment of planar polarity involved in mesonephric nephron morphogenesis namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] synonym: "establishment of planar cell polarity involved in mesonephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10] is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis [Term] id: GO:0061239 name: mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis [Term] id: GO:0061240 name: mesonephric nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072171 ! mesonephric tubule morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis relationship: part_of GO:0061242 ! mesonephric nephron tubule development [Term] id: GO:0061241 name: mesonephric nephron epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072163 ! mesonephric epithelium development relationship: part_of GO:0061215 ! mesonephric nephron development [Term] id: GO:0061242 name: mesonephric nephron tubule development namespace: biological_process def: "The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061241 ! mesonephric nephron epithelium development is_a: GO:0072080 ! nephron tubule development is_a: GO:0072164 ! mesonephric tubule development [Term] id: GO:0061243 name: mesonephric renal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072077 ! renal vesicle morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis [Term] id: GO:0061244 name: mesonephric S-shaped body morphogenesis namespace: biological_process def: "The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072050 ! S-shaped body morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis [Term] id: GO:0061245 name: establishment or maintenance of bipolar cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0061246 name: establishment or maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell." [GOC:dph, GOC:vw] is_a: GO:0008360 ! regulation of cell shape is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity [Term] id: GO:0061247 name: mesonephric glomerular mesangium development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072109 ! glomerular mesangium development relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development [Term] id: GO:0061248 name: mesonephric glomerulus vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072103 ! glomerulus vasculature morphogenesis relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development relationship: part_of GO:0061234 ! mesonephric glomerulus morphogenesis [Term] id: GO:0061249 name: mesonephric glomerular capillary formation namespace: biological_process def: "The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] is_a: GO:0072104 ! glomerular capillary formation relationship: part_of GO:0061248 ! mesonephric glomerulus vasculature morphogenesis [Term] id: GO:0061250 name: mesonephric glomerular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072311 ! glomerular epithelial cell differentiation relationship: part_of GO:0061232 ! mesonephric glomerular epithelium development [Term] id: GO:0061251 name: mesonephric glomerular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation [Term] id: GO:0061252 name: mesonephric glomerular epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072314 ! glomerular epithelial cell fate commitment relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation [Term] id: GO:0061253 name: mesonephric glomerular parietal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation [Term] id: GO:0061254 name: mesonephric glomerular parietal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] is_a: GO:0061251 ! mesonephric glomerular epithelial cell development is_a: GO:0072016 ! glomerular parietal epithelial cell development relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation [Term] id: GO:0061255 name: mesonephric glomerular parietal epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10] is_a: GO:0061252 ! mesonephric glomerular epithelial cell fate commitment is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation [Term] id: GO:0061256 name: mesonephric glomerular visceral epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \\\"feet\\\" that interdigitate with the \\\"feet\\\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation is_a: GO:0072112 ! glomerular visceral epithelial cell differentiation [Term] id: GO:0061257 name: mesonephric glomerular visceral epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \\\"feet\\\" that interdigitate with the \\\"feet\\\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061251 ! mesonephric glomerular epithelial cell development is_a: GO:0072015 ! glomerular visceral epithelial cell development relationship: part_of GO:0061256 ! mesonephric glomerular visceral epithelial cell differentiation [Term] id: GO:0061258 name: mesonephric glomerular visceral epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \\\"feet\\\" that interdigitate with the \\\"feet\\\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061251 ! mesonephric glomerular epithelial cell development is_a: GO:0072149 ! glomerular visceral epithelial cell fate commitment relationship: part_of GO:0061256 ! mesonephric glomerular visceral epithelial cell differentiation [Term] id: GO:0061259 name: mesonephric glomerular mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061260 ! mesonephric mesangial cell differentiation is_a: GO:0072008 ! glomerular mesangial cell differentiation relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development [Term] id: GO:0061260 name: mesonephric mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072007 ! mesangial cell differentiation [Term] id: GO:0061261 name: mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephric mesenchyme to epithelial transition" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0060231 ! mesenchymal to epithelial transition relationship: part_of GO:0061206 ! mesonephros morphogenesis [Term] id: GO:0061262 name: mesonephric renal vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephros formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072033 ! renal vesicle formation relationship: part_of GO:0061243 ! mesonephric renal vesicle morphogenesis [Term] id: GO:0061263 name: mesonephric glomerular mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072144 ! glomerular mesangial cell development relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation [Term] id: GO:0061264 name: mesonephric glomerular mesangial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell." [GOC:mtg_kidney_jan10] is_a: GO:0072152 ! glomerular mesangial cell fate commitment relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation [Term] id: GO:0061265 name: mesonephric nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072160 ! nephron tubule epithelial cell differentiation relationship: part_of GO:0061242 ! mesonephric nephron tubule development [Term] id: GO:0061266 name: mesonephric interstitial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "mesonephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072071 ! renal interstitial cell differentiation [Term] id: GO:0061267 name: mesonephric interstitial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric interstitial cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "mesonephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072141 ! renal interstitial cell development relationship: part_of GO:0061266 ! mesonephric interstitial cell differentiation [Term] id: GO:0061268 name: mesonephric interstitial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric interstitial cell." [GOC:mtg_kidney_jan10] is_a: GO:0072153 ! renal interstitial cell fate commitment relationship: part_of GO:0061266 ! mesonephric interstitial cell differentiation [Term] id: GO:0061269 name: mesonephric glomerular mesangial cell proliferation involved in mesonephros development namespace: biological_process def: "The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10] is_a: GO:0061209 ! cell proliferation involved in mesonephros development is_a: GO:0072110 ! glomerular mesangial cell proliferation relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development [Term] id: GO:0061270 name: mesonephric intraglomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10] is_a: GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development is_a: GO:0072123 ! intraglomerular mesangial cell proliferation [Term] id: GO:0061271 name: mesenchymal to epithelial transition involved in mesonephric renal vesicle formation namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation relationship: part_of GO:0061262 ! mesonephric renal vesicle formation [Term] id: GO:0061272 name: mesonephric connecting tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephric collecting tubule development" EXACT [GOC:dph] synonym: "mesonephric connecting duct development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061242 ! mesonephric nephron tubule development is_a: GO:0072027 ! connecting tubule development [Term] id: GO:0061273 name: mesonephric distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis is_a: GO:0072156 ! distal tubule morphogenesis relationship: part_of GO:0061274 ! mesonephric distal tubule development [Term] id: GO:0061274 name: mesonephric distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061242 ! mesonephric nephron tubule development is_a: GO:0072017 ! distal tubule development [Term] id: GO:0061275 name: mesonephric proximal tubule development namespace: biological_process def: "The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061242 ! mesonephric nephron tubule development is_a: GO:0072014 ! proximal tubule development [Term] id: GO:0061276 name: mesonephric proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis is_a: GO:0072158 ! proximal tubule morphogenesis relationship: part_of GO:0061275 ! mesonephric proximal tubule development [Term] id: GO:0061277 name: mesonephric nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072172 ! mesonephric tubule formation relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis [Term] id: GO:0061278 name: epithelial cell migration involved in mesonephric nephron tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis [Term] id: GO:0061279 name: epithelial cell migration involved in mesonephric distal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis [Term] id: GO:0061280 name: epithelial cell migration involved in mesonephric proximal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis [Term] id: GO:0061281 name: specification of mesonephric connecting tubule identity namespace: biological_process def: "The process in which the connecting tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10] synonym: "specification of mesonephric collecting tubule identity" EXACT [GOC:dph] is_a: GO:0061282 ! specification of mesonephric nephron tubule identity is_a: GO:0072085 ! specification of connecting tubule identity relationship: part_of GO:0061272 ! mesonephric connecting tubule development [Term] id: GO:0061282 name: specification of mesonephric nephron tubule identity namespace: biological_process def: "The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0061226 ! proximal/distal pattern formation involved in mesonephric nephron development relationship: part_of GO:0061277 ! mesonephric nephron tubule formation [Term] id: GO:0061283 name: specification of mesonephric distal tubule identity namespace: biological_process def: "The process in which the distal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0061282 ! specification of mesonephric nephron tubule identity is_a: GO:0072084 ! specification of distal tubule identity relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis [Term] id: GO:0061284 name: specification of mesonephric proximal tubule identity namespace: biological_process def: "The process in which the proximal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0061282 ! specification of mesonephric nephron tubule identity is_a: GO:0072082 ! specification of proximal tubule identity relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis [Term] id: GO:0061285 name: mesonephric capsule development namespace: biological_process def: "The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." [GOC:mtg_kidney_jan10] is_a: GO:0072127 ! renal capsule development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0061286 name: mesonephric capsule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072128 ! renal capsule morphogenesis relationship: part_of GO:0061285 ! mesonephric capsule development [Term] id: GO:0061287 name: mesonephric capsule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072129 ! renal capsule formation relationship: part_of GO:0061286 ! mesonephric capsule morphogenesis [Term] id: GO:0061288 name: mesonephric capsule specification namespace: biological_process def: "The regionalization process in which the identity of the mesonephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] is_a: GO:0072130 ! renal capsule specification relationship: part_of GO:0061287 ! mesonephric capsule formation [Term] id: GO:0061289 name: Wnt receptor signaling pathway involved in kidney development namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the kidney over time." [GOC:mtg_kidney_jan10] synonym: "Wnt receptor signalling pathway involved in kidney development" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0061290 name: canonical Wnt receptor signaling pathway involved in metanephric kidney development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] synonym: "canonical Wnt receptor signalling pathway involved in metanephric kidney development" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway is_a: GO:0061289 ! Wnt receptor signaling pathway involved in kidney development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0061291 name: canonical Wnt receptor signaling pathway involved in ureteric bud branching namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] synonym: "canonical Wnt receptor signalling pathway involved in ureteric bud branching" EXACT [GOC:mah] is_a: GO:0061290 ! canonical Wnt receptor signaling pathway involved in metanephric kidney development relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis [Term] id: GO:0061292 name: canonical Wnt receptor signaling pathway involved in mesonephros development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the mesonephros over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] synonym: "canonical Wnt receptor signalling pathway involved in mesonephros development" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt receptor signaling pathway is_a: GO:0061289 ! Wnt receptor signaling pathway involved in kidney development [Term] id: GO:0061293 name: canonical Wnt receptor signaling pathway involved in mesonephric nephron development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the mesonephric nephron over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] synonym: "canonical Wnt receptor signalling pathway involved in mesonephric nephron development" EXACT [GOC:mah] is_a: GO:0061292 ! canonical Wnt receptor signaling pathway involved in mesonephros development relationship: part_of GO:0061215 ! mesonephric nephron development [Term] id: GO:0061294 name: mesonephric renal vesicle induction namespace: biological_process def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0072034 ! renal vesicle induction relationship: positively_regulates GO:0061262 ! mesonephric renal vesicle formation [Term] id: GO:0061295 name: regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0072039 ! regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis relationship: regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis [Term] id: GO:0061296 name: negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0061295 ! regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis is_a: GO:0072040 ! negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis relationship: negatively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis [Term] id: GO:0061297 name: positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:0061295 ! regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis is_a: GO:0072041 ! positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis relationship: positively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis [Term] id: GO:0061298 name: retina vasculature development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] synonym: "retinal vasculature development" EXACT [GOC:dph] is_a: GO:0001944 ! vasculature development relationship: part_of GO:0060041 ! retina development in camera-type eye [Term] id: GO:0061299 name: retina vasculature morphogenesis in camera-type eye namespace: biological_process def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph] synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0061298 ! retina vasculature development in camera-type eye [Term] id: GO:0061300 name: cerebellum vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0001944 ! vasculature development [Term] id: GO:0061301 name: cerebellum vasculature morphogenesis namespace: biological_process def: "The process in which the vasculature of the cerebellum is generated and organized." [GOC:BHF, GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021549 ! cerebellum development relationship: part_of GO:0061300 ! cerebellum vasculature development [Term] id: GO:0061302 name: smooth muscle cell-matrix adhesion namespace: biological_process def: "The binding of a smooth muscle cell to the extracellular matrix via adhesion molecules." [GOC:BHF, GOC:dph, PMID:8837777] is_a: GO:0007160 ! cell-matrix adhesion [Term] id: GO:0061303 name: cornea development in camera-type eye namespace: biological_process def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0061304 name: retinal blood vessel morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] is_a: GO:0048514 ! blood vessel morphogenesis is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye [Term] id: GO:0061305 name: maintenance of bipolar cell polarity regulating in cell shape namespace: biological_process def: "The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell." [GOC:dph, GOC:vw] is_a: GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape [Term] id: GO:0061306 name: DNA strand renaturation involved in double-strand break repair namespace: biological_process def: "The identification and annealing of complementary base pairs in single-strand DNA that contributes to double-strand break repair." [GOC:dph] is_a: GO:0000733 ! DNA strand renaturation relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0061307 name: cardiac neural crest cell differentiation involved in heart development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442] is_a: GO:0014033 ! neural crest cell differentiation is_a: GO:0035051 ! cardiac cell differentiation [Term] id: GO:0061308 name: cardiac neural crest cell development involved in heart development namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0014032 ! neural crest cell development relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development [Term] id: GO:0061309 name: cardiac neural crest cell development involved in outflow tract morphogenesis namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development [Term] id: GO:0061310 name: canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in cardiac neural crest cell differentiation." [GOC:dph, GOC:mtg_heart] synonym: "canonical Wnt receptor signalling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:mah] is_a: GO:0044335 ! canonical Wnt receptor signaling pathway involved in neural crest cell differentiation is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development [Term] id: GO:0061311 name: cell surface receptor linked signaling pathway involved in heart development namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell contributing to the progression of the heart over time." [GOC:dph, GOC:mtg_heart] synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor linked signaling pathway relationship: part_of GO:0007507 ! heart development [Term] id: GO:0061312 name: BMP signaling pathway involved in heart development namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the progression of the heart over time." [GOC:dph, GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0061311 ! cell surface receptor linked signaling pathway involved in heart development [Term] id: GO:0061313 name: fibroblast growth factor receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands and contributing to the progression of the heart over time." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0061311 ! cell surface receptor linked signaling pathway involved in heart development [Term] id: GO:0061314 name: Notch signaling involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time." [GOC:mtg_heart] synonym: "Notch signalling involved in heart development" EXACT [GOC:mah] is_a: GO:0007219 ! Notch signaling pathway is_a: GO:0061311 ! cell surface receptor linked signaling pathway involved in heart development [Term] id: GO:0061315 name: canonical Wnt receptor signaling pathway involved in positive regulation of cardiac muscle cell proliferation namespace: biological_process def: "The canonical Wnt receptor signaling pathway that contributes to an expansion of the population of cardiac muscle cells." [GOC:mtg_heart] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [GOC:mah] is_a: GO:0044340 ! canonical Wnt receptor signaling pathway involved in regulation of cell proliferation is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development relationship: part_of GO:0060045 ! positive regulation of cardiac muscle cell proliferation [Term] id: GO:0061316 name: canonical Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart] synonym: "canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0003306 ! Wnt receptor signaling pathway involved in heart development is_a: GO:0060070 ! canonical Wnt receptor signaling pathway [Term] id: GO:0061317 name: canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart, PMID:17576928] synonym: "canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:mah] is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development relationship: part_of GO:0060923 ! cardiac muscle cell fate commitment [Term] id: GO:0061318 name: renal filtration cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0061319 name: nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002520, GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0061318 ! renal filtration cell differentiation [Term] id: GO:0061320 name: pericardial nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0061319 ! nephrocyte differentiation [Term] id: GO:0061321 name: garland nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0061319 ! nephrocyte differentiation [Term] id: GO:0061322 name: disseminated nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002524, GOC:19783135, GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0061319 ! nephrocyte differentiation [Term] id: GO:0061323 name: cell proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0061324 name: canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation namespace: biological_process def: "The canonical Wnt receptor signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells." [GOC:dph, GOC:mtg_heart] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [GOC:mah] is_a: GO:0044340 ! canonical Wnt receptor signaling pathway involved in regulation of cell proliferation is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis relationship: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis [Term] id: GO:0061325 name: cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis [Term] id: GO:0061326 name: renal tubule development namespace: biological_process def: "The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0061327 name: anterior Malpighian tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0072002 ! Malpighian tubule development [Term] id: GO:0061328 name: posterior Malpighian tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0072002 ! Malpighian tubule development [Term] id: GO:0061329 name: Malpighian tubule principal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0072002 ! Malpighian tubule development [Term] id: GO:0061330 name: Malpighian tubule stellate cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0072002 ! Malpighian tubule development [Term] id: GO:0061331 name: cell proliferation involved in Malpighian tubule morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis [Term] id: GO:0061332 name: Malpighian tubule bud morphogenesis namespace: biological_process def: "The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] synonym: "Malpighian tubule formation" EXACT [GOC:dph] is_a: GO:0060572 ! morphogenesis of an epithelial bud is_a: GO:0072079 ! nephron tubule formation relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis [Term] id: GO:0061333 name: renal tubule morphogenesis namespace: biological_process def: "The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0061326 ! renal tubule development [Term] id: GO:0061334 name: cell rearrangement involved in Malpighian tubule morphogenesis namespace: biological_process def: "The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0048870 ! cell motility relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis [Term] id: GO:0061335 name: cell growth involved in Malpighian tubule morphogenesis namespace: biological_process def: "The growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis [Term] id: GO:0061336 name: cell morphogenesis involved in Malpighian tubule morphogenesis namespace: biological_process def: "The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis [Term] id: GO:0061337 name: cardiac conduction namespace: biological_process def: "A heart process that regulates cardiac muscle contraction through signal initiation and propagation." [GOC:dph] is_a: GO:0003015 ! heart process is_a: GO:0055117 ! regulation of cardiac muscle contraction [Term] id: GO:0061338 name: atrioventricular node impulse conduction delay namespace: biological_process def: "A heart process that modulates the propagation of the signal that causes the heart muscle to contract." [GOC:dph] is_a: GO:0003015 ! heart process relationship: part_of GO:0061337 ! cardiac conduction [Term] id: GO:0061339 name: establishment or maintenance of monopolar cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0061340 name: establishment or maintenance of monopolar cell polarity regulating in cell shape namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a monopolar intracellular organization or cell growth patterns that regulating the shape of a cell." [GOC:dph, GOC:vw] is_a: GO:0008360 ! regulation of cell shape is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity [Term] id: GO:0061341 name: non-canonical Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, PMID:16860783] synonym: "non-canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0003306 ! Wnt receptor signaling pathway involved in heart development is_a: GO:0035567 ! non-canonical Wnt receptor signaling pathway [Term] id: GO:0061342 name: regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway namespace: biological_process def: "Any process that decreased the extent of cell adhesion that contributes to the shaping of the heart." [PMID:16860783] synonym: "regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway" EXACT [GOC:mah] is_a: GO:0061341 ! non-canonical Wnt receptor signaling pathway involved in heart development is_a: GO:0061344 ! regulation of cell adhesion involved in heart morphogenesis [Term] id: GO:0061343 name: cell adhesion involved in heart morphogenesis namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0007155 ! cell adhesion relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0061344 name: regulation of cell adhesion involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis [Term] id: GO:0061345 name: planar cell polarity pathway involved in cardiac muscle cell fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to a cardioblast being committed to a cardiac muscle cell fate." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway is_a: GO:0061341 ! non-canonical Wnt receptor signaling pathway involved in heart development [Term] id: GO:0061346 name: planar cell polarity pathway involved in heart morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway is_a: GO:0061341 ! non-canonical Wnt receptor signaling pathway involved in heart development relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0061347 name: planar cell polarity pathway involved in outflow tract morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis [Term] id: GO:0061348 name: planar cell polarity pathway involved in ventricular septum morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0061349 name: planar cell polarity pathway involved in cardiac right atrium morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis [Term] id: GO:0061350 name: planar cell polarity pathway involved in cardiac muscle tissue morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis [Term] id: GO:0061351 name: neural precursor cell proliferation namespace: biological_process def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0061352 name: cell chemotaxis involved in Malpighian tubule morphogenesis namespace: biological_process def: "The directed movement of the outgrowing Malpighian tubule guided by specific chemical cues/signals. Movement may be towards a guidance cue (positive chemotaxis) or away from it (negative chemotaxis). Guidance contributes to the final positioning of the tubule." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0060326 ! cell chemotaxis is_a: GO:0061334 ! cell rearrangement involved in Malpighian tubule morphogenesis [Term] id: GO:0061353 name: BMP signaling pathway involved in Malpighian tubule cell chemotaxis namespace: biological_process def: "The series of molecular signals generated as a consequence of a BMP receptor binding to one of its physiological ligands leading to the directed movement of a Malpighian tubule cells toward a stimulus and contributing to the shaping of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] synonym: "bone morphogenic protein receptor signalling pathway involved in Malpighian tubule cell chemotaxis" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0061352 ! cell chemotaxis involved in Malpighian tubule morphogenesis [Term] id: GO:0061354 name: planar cell polarity pathway involved in pericardium morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: part_of GO:0003344 ! pericardium morphogenesis [Term] id: GO:0061355 name: Wnt protein secretion namespace: biological_process def: "The controlled release of a Wnt protein from a cell or group of cells." [GOC:bf, PMID:19223472] is_a: GO:0009306 ! protein secretion is_a: GO:0023061 ! signal release [Term] id: GO:0061356 name: regulation of Wnt protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell or group of cells." [GOC:bf, PMID:19223472] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0050708 ! regulation of protein secretion relationship: regulates GO:0061355 ! Wnt protein secretion [Term] id: GO:0061357 name: positive regulation of Wnt protein secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell or group of cells." [GOC:bf, PMID:19223472] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0061356 ! regulation of Wnt protein secretion relationship: positively_regulates GO:0061355 ! Wnt protein secretion [Term] id: GO:0061358 name: negative regulation of Wnt protein secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell or group of cells." [GOC:bf, PMID:19223472] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0061356 ! regulation of Wnt protein secretion relationship: negatively_regulates GO:0061355 ! Wnt protein secretion [Term] id: GO:0061359 name: regulation of Wnt receptor signaling pathway by Wnt protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signaling pathway by the controlled release of a Wnt protein from a cell or group of cells." [GOC:bf, GOC:jl, PMID:19223472] synonym: "regulation of Wnt receptor signalling pathway by Wnt protein secretion" EXACT [GOC:mah] is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway is_a: GO:0061355 ! Wnt protein secretion [Term] id: GO:0061360 name: optic chiasma development namespace: biological_process def: "The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature." [GOC:dph] synonym: "optic chiasm development" EXACT [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021554 ! optic nerve development [Term] id: GO:0061361 name: positive regulation of maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph] is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape relationship: positively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating in cell shape [Term] id: GO:0061362 name: negative regulation of maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape relationship: negatively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating in cell shape [Term] id: GO:0061363 name: negative regulation of progesterone biosynthesis involved in luteolysis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis." [GOC:dph] synonym: "functional luteolysis" EXACT [GOC:dph] is_a: GO:2000183 ! negative regulation of progesterone biosynthetic process relationship: negatively_regulates GO:0006701 ! progesterone biosynthetic process relationship: part_of GO:0001554 ! luteolysis [Term] id: GO:0061364 name: apoptosis involved in luteolysis namespace: biological_process def: "The process of apoptosis that contributes to luteolysis." [PMID:18566128] synonym: "structural luteolysis" EXACT [GOC:dph] is_a: GO:0006915 ! apoptosis is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0001554 ! luteolysis [Term] id: GO:0061365 name: positive regulation of triglyceride lipase activity namespace: biological_process def: "Any process that increases the activity of triglyceride lipase." [GOC:dph] is_a: GO:0060193 ! positive regulation of lipase activity [Term] id: GO:0061366 name: behavioral response to chemical pain namespace: biological_process def: "Any process that results in a change in the behaviour of an organism as a result of a chemical pain stimulus." [GOC:dph] is_a: GO:0007635 ! chemosensory behavior is_a: GO:0048266 ! behavioral response to pain [Term] id: GO:0061367 name: behavioral response to acetic acid induced pain namespace: biological_process def: "Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus." [GOC:dph] is_a: GO:0061366 ! behavioral response to chemical pain [Term] id: GO:0061368 name: behavioral response to formalin induced pain namespace: biological_process def: "Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus." [GOC:dph] is_a: GO:0061366 ! behavioral response to chemical pain [Term] id: GO:0061369 name: negative regulation of testicular blood vessel morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle." [GOC:BHF, GOC:dph] synonym: "negative regulation of testicular vasculature morphogenesis" BROAD [GOC:BHF, GOC:dph] is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis [Term] id: GO:0061370 name: testosterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5." [GOC:dph] is_a: GO:0006702 ! androgen biosynthetic process [Term] id: GO:0061371 name: determination of heart left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the heart with respect to the left and right halves of the organism." [GOC:dph, GOC:mtg_heart] synonym: "determination of cardiac left/right asymmetry" EXACT [GOC:dph] is_a: GO:0007368 ! determination of left/right symmetry [Term] id: GO:0061372 name: activin receptor signaling pathway involved in heart jogging namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor and contributing to the process of heart jogging." [GOC:dph, GOC:mtg_heart] synonym: "activin receptor signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0032924 ! activin receptor signaling pathway relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0061373 name: mammillary axonal complex development namespace: biological_process def: "The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain." [GOC:dph, PMID:10662642] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021767 ! mammillary body development [Term] id: GO:0061374 name: mammillothalamic axonal tract development namespace: biological_process def: "The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit." [GOC:dph, PMID:10662642] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061373 ! mammillary axonal complex development [Term] id: GO:0061375 name: mammillotectal axonal tract development namespace: biological_process def: "The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus." [GOC:dph, PMID:10662642] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061373 ! mammillary axonal complex development [Term] id: GO:0061376 name: mammillotegmental axonal tract development namespace: biological_process def: "The process in which the mammillotegmental tract progresses over time, from its formation to the mature structure. The mammillotegmental tract is the collection of axons that connects the ventral diencephalon to the tegmentum and pons." [GOC:dph, PMID:10662642] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061373 ! mammillary axonal complex development [Term] id: GO:0061377 name: mammary gland lobule development namespace: biological_process def: "The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0061378 name: corpora quadrigemina development namespace: biological_process def: "The progression of the corpora quadrigemina over time, from its formation to the mature structure. The corpora quadrigemina is a part of the midbrain that is made up of the superior and inferior colliculi." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030901 ! midbrain development [Term] id: GO:0061379 name: inferior colliculus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061378 ! corpora quadrigemina development [Term] id: GO:0061380 name: superior colliculus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061378 ! corpora quadrigemina development [Term] id: GO:0061381 name: cell migration in diencephalon namespace: biological_process def: "The orderly movement of a cell that will reside in the diencephalon." [GOC:dph] is_a: GO:0021885 ! forebrain cell migration relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0061382 name: Malpighian tubule tip cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0072002 ! Malpighian tubule development [Term] id: GO:0061383 name: trabecula morphogenesis namespace: biological_process def: "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0061384 name: heart trabecular morphogenesis namespace: biological_process def: "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] is_a: GO:0061383 ! trabecula morphogenesis [Term] id: GO:0061385 name: fibroblast proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis [Term] id: GO:0061386 name: closure of optic fissure namespace: biological_process def: "The closure of the temporary ventral gap in the optic cup that contributes to its shaping." [GOC:dph] synonym: "closure or choriod fissure" RELATED [GOC:dph] is_a: GO:0002011 ! morphogenesis of an epithelial sheet relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development [Term] id: GO:0065001 name: specification of axis polarity namespace: biological_process def: "The pattern specification process in which the polarity of a body or organ axis is established and maintained." [GOC:mah] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0009798 ! axis specification [Term] id: GO:0065002 name: intracellular protein transmembrane transport namespace: biological_process def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete] synonym: "intracellular membrane translocation of a protein" EXACT [] synonym: "intracellular protein transport across a membrane" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0065003 name: macromolecular complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex." [GOC:jl] subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "macromolecule complex assembly" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0065004 name: protein-DNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] subset: gosubset_prok synonym: "DNA-protein complex assembly" EXACT [GOC:mah] is_a: GO:0034622 ! cellular macromolecular complex assembly is_a: GO:0071824 ! protein-DNA complex subunit organization [Term] id: GO:0065005 name: protein-lipid complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex." [GOC:jl] subset: gosubset_prok is_a: GO:0065003 ! macromolecular complex assembly is_a: GO:0071825 ! protein-lipid complex subunit organization [Term] id: GO:0065006 name: protein-carbohydrate complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and carbohydrates to form a protein-carbohydrate complex." [GOC:jl] subset: gosubset_prok is_a: GO:0065003 ! macromolecular complex assembly is_a: GO:0071823 ! protein-carbohydrate complex subunit organization [Term] id: GO:0065007 name: biological regulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any biological process, quality or function." [GOC:isa_complete] subset: goslim_pir subset: gosubset_prok synonym: "regulation" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0065008 name: regulation of biological quality namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:isa_complete] subset: gosubset_prok synonym: "regulation of biological attribute" EXACT [] synonym: "regulation of biological characteristic" EXACT [] is_a: GO:0065007 ! biological regulation [Term] id: GO:0065009 name: regulation of molecular function namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] subset: gosubset_prok synonym: "regulation of a molecular function" EXACT [] is_a: GO:0065007 ! biological regulation [Term] id: GO:0065010 name: extracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] synonym: "extracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043230 ! extracellular organelle [Term] id: GO:0070001 name: aspartic-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0070002 name: glutamic-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0070003 name: threonine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0070004 name: cysteine-type exopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] is_a: GO:0008234 ! cysteine-type peptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0070005 name: cysteine-type aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] xref: EC:3.4.18 is_a: GO:0004177 ! aminopeptidase activity is_a: GO:0070004 ! cysteine-type exopeptidase activity [Term] id: GO:0070006 name: metalloaminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] is_a: GO:0004177 ! aminopeptidase activity is_a: GO:0008235 ! metalloexopeptidase activity [Term] id: GO:0070007 name: glutamic-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070002 ! glutamic-type peptidase activity [Term] id: GO:0070008 name: serine-type exopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE, ISBN:0716720094] subset: gosubset_prok xref: EC:3.4.21 is_a: GO:0008236 ! serine-type peptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0070009 name: serine-type aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] is_a: GO:0004177 ! aminopeptidase activity is_a: GO:0070008 ! serine-type exopeptidase activity [Term] id: GO:0070010 name: peptidase activity, acting on D-amino acid peptides namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds formed between D-amino acids." [GOC:mah] is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070011 name: peptidase activity, acting on L-amino acid peptides namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids." [GOC:mah] subset: gosubset_prok is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070012 name: oligopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070013 name: intracellular organelle lumen namespace: cellular_component def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] is_a: GO:0043233 ! organelle lumen is_a: GO:0044446 ! intracellular organelle part [Term] id: GO:0070014 name: sucrase-isomaltase complex namespace: cellular_component def: "A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities." [PMID:3366777] synonym: "oligo-1,6-glucosidase complex" RELATED [] xref: Wikipedia:Sucrase-isomaltase is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0070016 name: armadillo repeat domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation." [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225] synonym: "Arm repeat domain binding" EXACT [] synonym: "armadillo domain binding" EXACT [] synonym: "armadillo repeat binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070017 name: alphav-beta3 integrin-thrombospondin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin." [PMID:2478219] synonym: "ITGAV-ITGB3-THBS1 complex" NARROW [CORUM:2846] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070018 name: transforming growth factor beta type I receptor complex namespace: cellular_component def: "A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers." [Reactome:REACT_7737] synonym: "TGF-beta type I receptor complex" EXACT [] synonym: "TGF-beta type I receptor dimer" EXACT [Reactome:REACT_7737] is_a: GO:0070022 ! transforming growth factor beta receptor complex [Term] id: GO:0070019 name: transforming growth factor beta type II receptor complex namespace: cellular_component def: "A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers." [Reactome:REACT_7415] synonym: "TGF-beta type II receptor complex" EXACT [] synonym: "TGF-beta type II receptor dimer" EXACT [Reactome:REACT_7415] is_a: GO:0070022 ! transforming growth factor beta receptor complex [Term] id: GO:0070020 name: transforming growth factor beta1-type II receptor complex namespace: cellular_component def: "A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer." [Reactome:REACT_7218] subset: goslim_pir synonym: "TGF-beta receptor II-TGF-beta1 complex" EXACT [] synonym: "TGF-beta1-type II receptor complex" EXACT [Reactome:REACT_7218] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070021 name: transforming growth factor beta1-type II receptor-type I receptor complex namespace: cellular_component def: "A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer." [Reactome:REACT_7425] subset: goslim_pir synonym: "TGF-beta 1:type II receptor:type I receptor complex" EXACT [Reactome:REACT_7425] synonym: "TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex" EXACT [] synonym: "TGF-beta1-type II receptor-type I receptor complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070022 name: transforming growth factor beta receptor complex namespace: cellular_component def: "A dimeric receptor complex that binds transforming growth factor beta (TGF-beta); consists of two TGF-beta receptor monomers." [GOC:mah, Reactome:REACT_7415, Reactome:REACT_7737] synonym: "TGF-beta receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0070023 name: interleukin-12-interleukin-12 receptor complex namespace: cellular_component def: "A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer." [PMID:11900991] subset: goslim_pir synonym: "IL12-IL12 receptor complex" EXACT [] synonym: "IL12B-IL12RB1-IL12RB2 complex" NARROW [CORUM:2020] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070024 name: CD19-Vav-PIK3R1 complex namespace: cellular_component def: "A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K)." [PMID:7528218] subset: goslim_pir synonym: "CD19-Vav-PI 3-kinase (p85 subunit) complex" EXACT [CORUM:2574] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070025 name: carbon monoxide binding namespace: molecular_function def: "Interacting selectively and non-covalently with carbon monoxide (CO)." [GOC:ecd] subset: gosubset_prok synonym: "CO binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0070026 name: nitric oxide binding namespace: molecular_function def: "Interacting selectively and non-covalently with nitric oxide (NO)." [GOC:ecd] subset: gosubset_prok synonym: "nitrogen monoxide binding" EXACT [] synonym: "nitrosyl binding" EXACT [CHEBI:16480] synonym: "NO binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0070027 name: carbon monoxide sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO)." [GOC:ecd] is_a: GO:0070025 ! carbon monoxide binding [Term] id: GO:0070028 name: regulation of transcription by carbon monoxide namespace: biological_process def: "Any process involving carbon monoxide that modulates the frequency, rate or extent of transcription." [GOC:ecd] subset: gosubset_prok synonym: "regulation of transcription by CO" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0071245 ! cellular response to carbon monoxide [Term] id: GO:0070029 name: alphav-beta3 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin." [PMID:7532190] synonym: "ITGAV-ITGB3-SPP1 complex" NARROW [CORUM:2358] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070030 name: alphav-beta1 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin." [PMID:7592829] synonym: "ITGAV-ITGB1-SPP1 complex" NARROW [CORUM:2885] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070031 name: alphav-beta5 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin." [PMID:7592829] synonym: "ITGAV-ITGB5-SPP1 complex" NARROW [CORUM:2347] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070032 name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof)." [PMID:7553862] synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)" NARROW [CORUM:795] synonym: "Vamp2-Snap25-Stx1a-Cplx1 complex" NARROW [CORUM:795] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070033 name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof)." [PMID:7553862] synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)" NARROW [CORUM:796] synonym: "Vamp2-Snap25-Stx1a-Cplx2 complex" NARROW [CORUM:796] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070034 name: telomeric RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the telomerase RNA template or to RNA complementary to it." [GOC:krc, PMID:16884717] synonym: "telomeric RNA repeat binding" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0070035 name: purine NTP-dependent helicase activity namespace: molecular_function def: "Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah] subset: gosubset_prok is_a: GO:0004386 ! helicase activity [Term] id: GO:0070036 name: GTP-dependent helicase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah] subset: gosubset_prok is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0070035 ! purine NTP-dependent helicase activity [Term] id: GO:0070037 name: rRNA (pseudouridine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule." [GOC:imk, GOC:mah] subset: gosubset_prok is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0070038 name: rRNA (pseudouridine-N3-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine." [GOC:imk, GOC:mah] subset: gosubset_prok is_a: GO:0070037 ! rRNA (pseudouridine) methyltransferase activity [Term] id: GO:0070039 name: rRNA (guanosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine." [GOC:imk, GOC:mah] subset: gosubset_prok is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0070040 name: rRNA (adenine-C2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C2-methyladenine." [GOC:imk, GOC:mah] subset: gosubset_prok is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0070041 name: rRNA (uridine-C5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine." [GOC:imk, GOC:mah] subset: gosubset_prok is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity [Term] id: GO:0070042 name: rRNA (uridine-N3-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine." [GOC:imk, GOC:mah] subset: gosubset_prok is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity [Term] id: GO:0070043 name: rRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine." [GOC:imk, GOC:mah] subset: gosubset_prok is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0070044 name: synaptobrevin 2-SNAP-25-syntaxin-1a complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434] synonym: "Snap25-Stx1a-Vamp2 complex" NARROW [] synonym: "SNARE complex (Snap25, Stx1a, Vamp2)" NARROW [CORUM:998] synonym: "SNARE complex (Stx1a, SNAP25, VAMP)" NARROW [CORUM:841] synonym: "Stx1a-SNAP25-VAMP complex" NARROW [CORUM:841] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070045 name: synaptobrevin 2-SNAP-25-syntaxin-2 complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx2, Snap25, Vamp2)" NARROW [CORUM:851] synonym: "Stx2-Snap25-Vamp2 complex" NARROW [CORUM:851] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070046 name: synaptobrevin 2-SNAP-25-syntaxin-3 complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx3, Snap25, Vamp2)" NARROW [CORUM:852] synonym: "Stx3-Snap25-Vamp2 complex" NARROW [CORUM:852] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070047 name: synaptobrevin 2-SNAP-25-syntaxin-4 complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx4, Snap25, Vamp2)" NARROW [CORUM:853] synonym: "Stx4-Snap25-Vamp2 complex" NARROW [CORUM:853] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070048 name: endobrevin-SNAP-25-syntaxin-1a complex namespace: cellular_component def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx1a, Snap25, Vamp8)" NARROW [CORUM:854] synonym: "Stx1a-Snap25-Vamp8 complex" NARROW [CORUM:854] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070049 name: endobrevin-SNAP-25-syntaxin-2 complex namespace: cellular_component def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx2, Snap25, Vamp8)" NARROW [CORUM:855] synonym: "Stx2-Snap25-Vamp8 complex" NARROW [CORUM:855] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070050 name: neuron homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] synonym: "neuron maintenance" EXACT [] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0070051 name: fibrinogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:BHF, GOC:mah, GOC:vk] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0070052 name: collagen V binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type V collagen." [GOC:BHF, GOC:mah] is_a: GO:0005518 ! collagen binding [Term] id: GO:0070053 name: thrombospondin receptor activity namespace: molecular_function def: "Combining with thrombospondin to initiate a change in cell activity." [GOC:BHF, GOC:vk] is_a: GO:0004872 ! receptor activity [Term] id: GO:0070054 name: mRNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process alt_id: GO:0061012 def: "Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, GOC:mah] comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. subset: gosubset_prok synonym: "cytosolic mRNA splicing" RELATED [GOC:curators] is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation is_a: GO:0006397 ! mRNA processing [Term] id: GO:0070055 name: HAC1-type intron splice site recognition and cleavage namespace: biological_process def: "The process in which the tertiary structure of a HAC1 type intron is recognized, and the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, PMID:10357823] subset: gosubset_prok is_a: GO:0006396 ! RNA processing relationship: part_of GO:0070054 ! mRNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0070056 name: prospore membrane leading edge namespace: cellular_component def: "The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization." [GOC:mah, PMID:14702385] synonym: "forespore membrane leading edge" EXACT [] is_a: GO:0044425 ! membrane part relationship: part_of GO:0005628 ! prospore membrane [Term] id: GO:0070057 name: prospore membrane spindle pole body attachment site namespace: cellular_component def: "The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus." [GOC:mah, PMID:14702385] synonym: "forespore membrane SPB attachment site" EXACT [] synonym: "forespore membrane spindle pole body attachment site" EXACT [] synonym: "prospore membrane SPB attachment site" EXACT [] is_a: GO:0044425 ! membrane part relationship: part_of GO:0005628 ! prospore membrane [Term] id: GO:0070058 name: tRNA gene clustering namespace: biological_process def: "The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae." [GOC:jh, GOC:mah, PMID:18708579] is_a: GO:0051276 ! chromosome organization is_a: GO:0051641 ! cellular localization [Term] id: GO:0070059 name: apoptosis in response to endoplasmic reticulum stress namespace: biological_process def: "Apoptosis that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, PMID:18701708] synonym: "apoptosis in response to ER stress" EXACT [] synonym: "apoptosis triggered by ER stress" EXACT [] synonym: "endoplasmic reticulum stress-induced apoptosis" EXACT [] synonym: "ER stress-induced apoptosis" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0070060 name: 'de novo' actin filament nucleation namespace: biological_process def: "The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament." [GOC:mah, PMID:17477841] synonym: "formin-mediated actin filament nucleation" NARROW [] synonym: "unbranched actin filament nucleation" RELATED [] is_a: GO:0045010 ! actin nucleation [Term] id: GO:0070061 name: fructose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose." [CHEBI:28757, GOC:BHF, GOC:mah] subset: gosubset_prok is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0070062 name: extracellular vesicular exosome namespace: cellular_component def: "A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:BHF, GOC:mah, PMID:15908444, PMID:17641064] is_a: GO:0031988 ! membrane-bounded vesicle is_a: GO:0065010 ! extracellular membrane-bounded organelle [Term] id: GO:0070063 name: RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase molecule or complex." [GOC:BHF, GOC:mah, GOC:txnOH] subset: gosubset_prok is_a: GO:0019899 ! enzyme binding [Term] id: GO:0070064 name: proline-rich region binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0070065 name: cellubrevin-VAMP4-syntaxin-16 complex namespace: cellular_component def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof)." [PMID:11839770] synonym: "SNARE complex (Vamp3, Vamp4, Stx16)" NARROW [CORUM:875] synonym: "Vamp3-Vamp4-Stx16 complex" NARROW [CORUM:875] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070066 name: cellubrevin-VAMP4-endobrevin-syntaxin-6 complex namespace: cellular_component def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof)." [PMID:11839770] synonym: "SNARE complex (Vamp3, Vamp4, Vam8, Stx6)" NARROW [CORUM:874] synonym: "Vamp3-Vamp4-Vam8-Stx6 complex" NARROW [CORUM:874] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070067 name: syntaxin-6-syntaxin-16-Vti1a complex namespace: cellular_component def: "A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070068 name: VAMP4-syntaxin-6-syntaxin-16-Vti1a complex namespace: cellular_component def: "A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770] synonym: "SNARE complex (Vamp4, Stx6, Stx16, Vti1a)" NARROW [CORUM:877] synonym: "Vamp4-Stx6-Stx16-Vti1a complex" RELATED [CORUM:877] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070069 name: cytochrome complex namespace: cellular_component def: "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah] is_a: GO:0043234 ! protein complex [Term] id: GO:0070070 name: proton-transporting V-type ATPase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient." [GOC:mah] synonym: "V-ATPase assembly" RELATED [] synonym: "V-ATPase complex assembly" RELATED [] is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly [Term] id: GO:0070071 name: proton-transporting two-sector ATPase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane." [GOC:mah] subset: gosubset_prok is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0070072 name: vacuolar proton-transporting V-type ATPase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah] synonym: "V-ATPase assembly" BROAD [] synonym: "V-ATPase complex assembly" BROAD [] is_a: GO:0070070 ! proton-transporting V-type ATPase complex assembly [Term] id: GO:0070073 name: clustering of voltage-gated calcium channels namespace: biological_process def: "The process in which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:183853250] synonym: "clustering of voltage gated calcium channels" EXACT [] synonym: "clustering of voltage-dependent calcium channels" EXACT [] synonym: "voltage-gated calcium channel clustering" EXACT [] is_a: GO:0045161 ! neuronal ion channel clustering [Term] id: GO:0070074 name: mononeme namespace: cellular_component def: "A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts." [GOC:BHF, PMID:18048320] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0070075 name: tear secretion namespace: biological_process def: "The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium." [GOC:rph] is_a: GO:0007589 ! body fluid secretion [Term] id: GO:0070076 name: histone lysine demethylation namespace: biological_process def: "The modification of a histone by the removal of a methyl group from a lysine residue." [GOC:mah] is_a: GO:0016577 ! histone demethylation [Term] id: GO:0070077 name: histone arginine demethylation namespace: biological_process def: "The modification of a histone by the removal of a methyl group from an arginine residue." [GOC:mah] is_a: GO:0016577 ! histone demethylation [Term] id: GO:0070078 name: histone H3-R2 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone." [GOC:vk] is_a: GO:0070077 ! histone arginine demethylation [Term] id: GO:0070079 name: histone H4-R3 demethylation namespace: biological_process def: "The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone." [GOC:vk] is_a: GO:0070077 ! histone arginine demethylation [Term] id: GO:0070080 name: titin Z domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34." [GOC:mah, InterPro:IPR015129] synonym: "Z repeat domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070081 name: clathrin sculpted monoamine transport vesicle namespace: cellular_component def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines." [GOC:mg2] is_a: GO:0030133 ! transport vesicle is_a: GO:0060198 ! clathrin sculpted vesicle [Term] id: GO:0070082 name: clathrin sculpted monoamine transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin sculpted monoamine transport vesicle." [GOC:mg2] is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0070081 ! clathrin sculpted monoamine transport vesicle [Term] id: GO:0070083 name: clathrin sculpted monoamine transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin sculpted monoamine transport vesicle." [GOC:mg2] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030665 ! clathrin coated vesicle membrane relationship: part_of GO:0070081 ! clathrin sculpted monoamine transport vesicle [Term] id: GO:0070084 name: protein initiator methionine removal namespace: biological_process def: "The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah] synonym: "removal of initiator methionine from protein" EXACT [] is_a: GO:0006464 ! protein modification process [Term] id: GO:0070085 name: glycosylation namespace: biological_process def: "The covalent attachment of a glycosyl residue to a substrate molecule." [GOC:mah] xref: Wikipedia:Glycosylation is_a: GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0070086 name: ubiquitin-dependent endocytosis namespace: biological_process def: "Endocytosis of a protein that requires the substrate to be modified by uniquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded." [GOC:jp, GOC:mah, PMID:9409540] synonym: "ubiquitin-mediated endocytosis" EXACT [GOC:jp] is_a: GO:0006897 ! endocytosis [Term] id: GO:0070087 name: chromo shadow domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain." [GOC:BHF, GOC:vk, InterPro:IPR008251, PMID:7667093] synonym: "chromoshadow domain binding" EXACT [GOC:vk] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070088 name: PHA granule namespace: cellular_component def: "An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR." [GOC:mah, PMID:15762612] subset: gosubset_prok synonym: "PHB granule" NARROW [] synonym: "polyhydroxyalkanoate granule" EXACT [] is_a: GO:0016234 ! inclusion body is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070089 name: chloride-activated potassium channel activity namespace: molecular_function def: "Catalysis of the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:kmv, GOC:mtg_transport] subset: gosubset_prok is_a: GO:0005267 ! potassium channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0070090 name: metaphase plate namespace: cellular_component def: "The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division." [GOC:mah] is_a: GO:0044424 ! intracellular part [Term] id: GO:0070091 name: glucagon secretion namespace: biological_process def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070092 name: regulation of glucagon secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] is_a: GO:0090276 ! regulation of peptide hormone secretion relationship: regulates GO:0070091 ! glucagon secretion [Term] id: GO:0070093 name: negative regulation of glucagon secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] synonym: "down regulation of glucagon secretion" EXACT [] synonym: "down-regulation of glucagon secretion" EXACT [] synonym: "downregulation of glucagon secretion" EXACT [] synonym: "inhibition of glucagon secretion" NARROW [] is_a: GO:0070092 ! regulation of glucagon secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion relationship: negatively_regulates GO:0070091 ! glucagon secretion [Term] id: GO:0070094 name: positive regulation of glucagon secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] synonym: "activation of glucagon secretion" NARROW [] synonym: "stimulation of glucagon secretion" NARROW [] synonym: "up regulation of glucagon secretion" EXACT [] synonym: "up-regulation of glucagon secretion" EXACT [] synonym: "upregulation of glucagon secretion" EXACT [] is_a: GO:0070092 ! regulation of glucagon secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion relationship: positively_regulates GO:0070091 ! glucagon secretion [Term] id: GO:0070095 name: fructose-6-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with fructose 6-phosphate." [GOC:mah] synonym: "D-fructose 6-phosphate binding" NARROW [] synonym: "fructose 6-phosphate binding" EXACT [] is_a: GO:0070061 ! fructose binding [Term] id: GO:0070096 name: mitochondrial outer membrane translocase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex." [GOC:BHF, GOC:vk] synonym: "TOM complex assembly" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007008 ! outer mitochondrial membrane organization [Term] id: GO:0070097 name: delta-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the delta subunit of the catenin complex." [GOC:rph] is_a: GO:0005515 ! protein binding [Term] id: GO:0070098 name: chemokine-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] synonym: "chemokine-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0070099 name: regulation of chemokine-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] synonym: "regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway relationship: regulates GO:0070098 ! chemokine-mediated signaling pathway [Term] id: GO:0070100 name: negative regulation of chemokine-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] synonym: "negative regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway relationship: negatively_regulates GO:0070098 ! chemokine-mediated signaling pathway [Term] id: GO:0070101 name: positive regulation of chemokine-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] synonym: "positive regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway relationship: positively_regulates GO:0070098 ! chemokine-mediated signaling pathway [Term] id: GO:0070102 name: interleukin-6-mediated signaling pathway namespace: biological_process def: "A series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:add, GOC:BHF, GOC:mah] synonym: "IL-6-mediated signaling pathway" RELATED [] synonym: "interleukin-6-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway is_a: GO:0071354 ! cellular response to interleukin-6 [Term] id: GO:0070103 name: regulation of interleukin-6-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] synonym: "regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway relationship: regulates GO:0070102 ! interleukin-6-mediated signaling pathway [Term] id: GO:0070104 name: negative regulation of interleukin-6-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "negative regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway relationship: negatively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway [Term] id: GO:0070105 name: positive regulation of interleukin-6-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "positive regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway relationship: positively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway [Term] id: GO:0070106 name: interleukin-27-mediated signaling pathway namespace: biological_process def: "A series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:add, GOC:BHF, GOC:mah] synonym: "IL-27-mediated signaling pathway" EXACT [GOC:mah] synonym: "IL27RA/IL6ST signaling pathway" EXACT [GOC:add] synonym: "interleukin-27-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0070107 name: regulation of interleukin-27-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] synonym: "regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] synonym: "regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway relationship: regulates GO:0070106 ! interleukin-27-mediated signaling pathway [Term] id: GO:0070108 name: negative regulation of interleukin-27-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "negative regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] synonym: "negative regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway relationship: negatively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway [Term] id: GO:0070109 name: positive regulation of interleukin-27-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "positive regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] synonym: "positive regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway relationship: positively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway [Term] id: GO:0070110 name: ciliary neurotrophic factor receptor complex namespace: cellular_component def: "A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR." [GOC:BHF, GOC:mah, GOC:rl, PMID:12707266] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0070111 name: organellar chromatophore namespace: cellular_component def: "A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora." [GOC:expert_mm, PMID:18356055] synonym: "Paulinella-type chromatophore" EXACT [] is_a: GO:0043660 ! bacteroid-containing symbiosome [Term] id: GO:0070112 name: organellar chromatophore membrane namespace: cellular_component def: "Either of the lipid bilayers that surround an organellar chromatophore." [GOC:mah] subset: gosubset_prok synonym: "Paulinella-type chromatophore membrane" EXACT [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0070111 ! organellar chromatophore [Term] id: GO:0070113 name: organellar chromatophore inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah] synonym: "Paulinella-type chromatophore inner membrane" EXACT [GOC:mah] is_a: GO:0070112 ! organellar chromatophore membrane [Term] id: GO:0070114 name: organellar chromatophore outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah] synonym: "Paulinella-type chromatophore outer membrane" EXACT [GOC:mah] is_a: GO:0043661 ! peribacteroid membrane is_a: GO:0070112 ! organellar chromatophore membrane [Term] id: GO:0070115 name: organellar chromatophore intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers that surround an organellar chromatophore." [GOC:mah] subset: gosubset_prok synonym: "Paulinella-type chromatophore intermembrane space" EXACT [GOC:mah] is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0070111 ! organellar chromatophore [Term] id: GO:0070116 name: organellar chromatophore thylakoid namespace: cellular_component def: "A thylakoid located in an organellar chromatophore." [GOC:mah] subset: gosubset_prok synonym: "Paulinella-type chromatophore thylakoid" EXACT [GOC:mah] is_a: GO:0009579 ! thylakoid is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0070111 ! organellar chromatophore [Term] id: GO:0070117 name: organellar chromatophore thylakoid lumen namespace: cellular_component def: "The volume enclosed by an organellar chromatophore thylakoid membrane." [GOC:mah] synonym: "Paulinella-type chromatophore thylakoid lumen" EXACT [GOC:mah] is_a: GO:0031977 ! thylakoid lumen is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0070116 ! organellar chromatophore thylakoid [Term] id: GO:0070118 name: organellar chromatophore thylakoid membrane namespace: cellular_component def: "The lipid bilayer membrane of any thylakoid within an organellar chromatophore." [GOC:mah] synonym: "Paulinella-type chromatophore thylakoid membrane" EXACT [GOC:mah] is_a: GO:0042651 ! thylakoid membrane is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0070116 ! organellar chromatophore thylakoid [Term] id: GO:0070119 name: ciliary neurotrophic factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor." [GOC:BHF, GOC:mah] synonym: "CNTF binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0070120 name: ciliary neurotrophic factor-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of ciliary neurotrophic factor binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "ciliary neurotrophic factor-mediated signalling pathway" EXACT [GOC:mah] synonym: "CNTF-mediated signaling pathway" EXACT [GOC:rl] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0070121 name: Kupffer's vesicle development namespace: biological_process def: "The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period." [GOC:dgh] synonym: "KV development" EXACT [GOC:dgh] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0070122 name: isopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond)." [GOC:mah, http://128.240.24.212/cgi-bin/omd?isopeptide+bond] is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070123 name: transforming growth factor beta receptor activity, type III namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors." [GOC:BHF, GOC:mah, PMID:9759503] synonym: "betaglycan" NARROW [] synonym: "endoglin" NARROW [] synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED [] synonym: "type III TGF-beta receptor activity" EXACT [] synonym: "type III TGFbeta receptor activity" EXACT [] synonym: "type III transforming growth factor beta receptor activity" EXACT [] is_a: GO:0005024 ! transforming growth factor beta receptor activity [Term] id: GO:0070124 name: mitochondrial translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah] synonym: "mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0006413 ! translational initiation relationship: part_of GO:0032543 ! mitochondrial translation [Term] id: GO:0070125 name: mitochondrial translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah] synonym: "mitochondrial translation elongation" EXACT [GOC:mah] is_a: GO:0006414 ! translational elongation relationship: part_of GO:0032543 ! mitochondrial translation [Term] id: GO:0070126 name: mitochondrial translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http://mitogenome.org/index.php/Genetic_Code_of_mitochondria] synonym: "mitochondrial translation termination" EXACT [GOC:mah] is_a: GO:0006415 ! translational termination relationship: part_of GO:0032543 ! mitochondrial translation [Term] id: GO:0070127 name: tRNA aminoacylation for mitochondrial protein translation namespace: biological_process def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion." [GOC:mah] is_a: GO:0006418 ! tRNA aminoacylation for protein translation relationship: part_of GO:0032543 ! mitochondrial translation [Term] id: GO:0070129 name: regulation of mitochondrial translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0006417 ! regulation of translation is_a: GO:0010821 ! regulation of mitochondrion organization relationship: regulates GO:0032543 ! mitochondrial translation [Term] id: GO:0070130 name: negative regulation of mitochondrial translation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0017148 ! negative regulation of translation is_a: GO:0070129 ! regulation of mitochondrial translation relationship: negatively_regulates GO:0032543 ! mitochondrial translation [Term] id: GO:0070131 name: positive regulation of mitochondrial translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0045727 ! positive regulation of translation is_a: GO:0070129 ! regulation of mitochondrial translation relationship: positively_regulates GO:0032543 ! mitochondrial translation [Term] id: GO:0070132 name: regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0070129 ! regulation of mitochondrial translation relationship: regulates GO:0070124 ! mitochondrial translational initiation [Term] id: GO:0070133 name: negative regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:0070132 ! regulation of mitochondrial translational initiation relationship: negatively_regulates GO:0070124 ! mitochondrial translational initiation [Term] id: GO:0070134 name: positive regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0045948 ! positive regulation of translational initiation is_a: GO:0070132 ! regulation of mitochondrial translational initiation relationship: positively_regulates GO:0070124 ! mitochondrial translational initiation [Term] id: GO:0070135 name: beta-1,2-oligomannoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669] synonym: "beta-1,2-oligomannoside metabolism" EXACT [GOC:mah] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0070136 name: beta-1,2-oligomannoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669] synonym: "beta-1,2-oligomannoside anabolism" EXACT [GOC:mah] synonym: "beta-1,2-oligomannoside biosynthesis" EXACT [GOC:mah] synonym: "beta-1,2-oligomannoside formation" EXACT [GOC:mah] synonym: "beta-1,2-oligomannoside synthesis" EXACT [GOC:mah] is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process is_a: GO:0070135 ! beta-1,2-oligomannoside metabolic process [Term] id: GO:0070137 name: small conjugating protein-specific endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)." [GOC:mah] is_a: GO:0004197 ! cysteine-type endopeptidase activity is_a: GO:0019783 ! small conjugating protein-specific protease activity [Term] id: GO:0070138 name: small conjugating protein-specific isopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an isopeptide bond between a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO) and a protein to which the small protein has been conjugated." [GOC:mah] is_a: GO:0019783 ! small conjugating protein-specific protease activity is_a: GO:0070122 ! isopeptidase activity [Term] id: GO:0070139 name: SUMO-specific endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah] is_a: GO:0016929 ! SUMO-specific protease activity is_a: GO:0070137 ! small conjugating protein-specific endopeptidase activity [Term] id: GO:0070140 name: SUMO-specific isopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated." [GOC:mah] is_a: GO:0016929 ! SUMO-specific protease activity is_a: GO:0070138 ! small conjugating protein-specific isopeptidase activity [Term] id: GO:0070141 name: response to UV-A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 400 to 500 nm." [GOC:BHF, GOC:mah] synonym: "response to UV-A light stimulus" EXACT [] synonym: "response to UV-A radiation stimulus" EXACT [] synonym: "response to UVA light stimulus" EXACT [] synonym: "response to UVA radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0070142 name: synaptic vesicle budding namespace: biological_process def: "Evagination of a membrane to form a synaptic vesicle." [GOC:mah] is_a: GO:0006900 ! membrane budding relationship: part_of GO:0048489 ! synaptic vesicle transport [Term] id: GO:0070143 name: mitochondrial alanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006419 ! alanyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070144 name: mitochondrial arginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006420 ! arginyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070145 name: mitochondrial asparaginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006421 ! asparaginyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070146 name: mitochondrial aspartyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006422 ! aspartyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070147 name: mitochondrial cysteinyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006423 ! cysteinyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070148 name: mitochondrial glutaminyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006425 ! glutaminyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070149 name: mitochondrial glutamyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006424 ! glutamyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070150 name: mitochondrial glycyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006426 ! glycyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070151 name: mitochondrial histidyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006427 ! histidyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070152 name: mitochondrial isoleucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006428 ! isoleucyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070153 name: mitochondrial leucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006429 ! leucyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070154 name: mitochondrial lysyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006430 ! lysyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070155 name: mitochondrial methionyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006431 ! methionyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070156 name: mitochondrial phenylalanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006432 ! phenylalanyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070157 name: mitochondrial prolyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006433 ! prolyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070158 name: mitochondrial seryl-tRNA aminoacylation namespace: biological_process def: "The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006434 ! seryl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070159 name: mitochondrial threonyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006435 ! threonyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070160 name: occluding junction namespace: cellular_component def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181] synonym: "occluding cell junction" EXACT [GOC:mah] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0070161 name: anchoring junction namespace: cellular_component def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] synonym: "anchoring cell junction" EXACT [GOC:mah] is_a: GO:0030054 ! cell junction [Term] id: GO:0070162 name: adiponectin secretion namespace: biological_process def: "The regulated release of adiponectin, a protein hormone, by adipose tissue." [GOC:BHF, GOC:rl] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0070163 name: regulation of adiponectin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell or group of cells." [GOC:mah] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0070162 ! adiponectin secretion [Term] id: GO:0070164 name: negative regulation of adiponectin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell or group of cells." [GOC:BHF, GOC:mah] synonym: "down regulation of adiponectin secretion" EXACT [GOC:mah] synonym: "down-regulation of adiponectin secretion" EXACT [GOC:mah] synonym: "downregulation of adiponectin secretion" EXACT [GOC:mah] synonym: "inhibition of adiponectin secretion" NARROW [GOC:mah] is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0070163 ! regulation of adiponectin secretion relationship: negatively_regulates GO:0070162 ! adiponectin secretion [Term] id: GO:0070165 name: positive regulation of adiponectin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell or group of cells." [GOC:BHF, GOC:mah] synonym: "activation of adiponectin secretion" NARROW [GOC:mah] synonym: "stimulation of adiponectin secretion" NARROW [GOC:mah] synonym: "up regulation of adiponectin secretion" EXACT [GOC:mah] synonym: "up-regulation of adiponectin secretion" EXACT [GOC:mah] synonym: "upregulation of adiponectin secretion" EXACT [GOC:mah] is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0070163 ! regulation of adiponectin secretion relationship: positively_regulates GO:0070162 ! adiponectin secretion [Term] id: GO:0070166 name: enamel mineralization namespace: biological_process def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel." [GOC:BHF, GOC:mah, PMID:16931858] synonym: "enamel formation" RELATED [PMID:16931858] is_a: GO:0034505 ! tooth mineralization [Term] id: GO:0070167 name: regulation of biomineral tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] synonym: "regulation of biomineral formation" EXACT [GOC:dph, GOC:tb] synonym: "regulation of biomineralization" EXACT [GOC:mah] synonym: "regulation of mineralization" EXACT [GOC:mah] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0031214 ! biomineral tissue development [Term] id: GO:0070168 name: negative regulation of biomineral tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] synonym: "negative regulation of biomineral formation" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of biomineralization" EXACT [GOC:mah] synonym: "negative regulation of mineralization" EXACT [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070167 ! regulation of biomineral tissue development relationship: negatively_regulates GO:0031214 ! biomineral tissue development [Term] id: GO:0070169 name: positive regulation of biomineral tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] synonym: "positive regulation of biomineral formation" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of biomineralization" EXACT [GOC:mah] synonym: "positive regulation of mineralization" EXACT [GOC:mah] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070167 ! regulation of biomineral tissue development relationship: positively_regulates GO:0031214 ! biomineral tissue development [Term] id: GO:0070170 name: regulation of tooth mineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0070167 ! regulation of biomineral tissue development relationship: regulates GO:0034505 ! tooth mineralization [Term] id: GO:0070171 name: negative regulation of tooth mineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] is_a: GO:0070168 ! negative regulation of biomineral tissue development is_a: GO:0070170 ! regulation of tooth mineralization relationship: negatively_regulates GO:0034505 ! tooth mineralization [Term] id: GO:0070172 name: positive regulation of tooth mineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] is_a: GO:0070169 ! positive regulation of biomineral tissue development is_a: GO:0070170 ! regulation of tooth mineralization relationship: positively_regulates GO:0034505 ! tooth mineralization [Term] id: GO:0070173 name: regulation of enamel mineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah] is_a: GO:0070170 ! regulation of tooth mineralization relationship: regulates GO:0070166 ! enamel mineralization [Term] id: GO:0070174 name: negative regulation of enamel mineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah] is_a: GO:0070171 ! negative regulation of tooth mineralization is_a: GO:0070173 ! regulation of enamel mineralization relationship: negatively_regulates GO:0070166 ! enamel mineralization [Term] id: GO:0070175 name: positive regulation of enamel mineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah] is_a: GO:0070172 ! positive regulation of tooth mineralization is_a: GO:0070173 ! regulation of enamel mineralization relationship: positively_regulates GO:0070166 ! enamel mineralization [Term] id: GO:0070176 name: DRM complex namespace: cellular_component def: "A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification." [PMID:17075059] synonym: "DP/Rb/MuvB" EXACT [PMID:17075059] is_a: GO:0017053 ! transcriptional repressor complex [Term] id: GO:0070177 name: contractile vacuole discharge namespace: biological_process def: "The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane." [GOC:mah, PMID:10369671] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0070178 name: D-serine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid." [CHEBI:16523, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-serine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0070179 name: D-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine." [CHEBI:16523, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "D-serine anabolism" EXACT [] synonym: "D-serine biosynthesis" EXACT [] synonym: "D-serine formation" EXACT [] synonym: "D-serine synthesis" EXACT [] is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0046437 ! D-amino acid biosynthetic process is_a: GO:0070178 ! D-serine metabolic process [Term] id: GO:0070180 name: LSU rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh] synonym: "25S rRNA binding" EXACT [GOC:elh] is_a: GO:0019843 ! rRNA binding [Term] id: GO:0070181 name: SSU rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [GOC:elh] synonym: "18S rRNA binding" EXACT [GOC:elh] is_a: GO:0019843 ! rRNA binding [Term] id: GO:0070182 name: DNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA polymerase." [GOC:BHF, GOC:mah] subset: gosubset_prok is_a: GO:0019899 ! enzyme binding [Term] id: GO:0070183 name: mitochondrial tryptophanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006436 ! tryptophanyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070184 name: mitochondrial tyrosyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling threonine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006437 ! tyrosyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070185 name: mitochondrial valyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006438 ! valyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation [Term] id: GO:0070186 name: growth hormone activity namespace: molecular_function def: "The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth." [GOC:BHF, GOC:mah, PMID:11445442] synonym: "GH activity" EXACT [PMID:11445442] synonym: "pituitary growth hormone activity" NARROW [GOC:vk] synonym: "placental growth hormone activity" NARROW [GOC:vk] is_a: GO:0005179 ! hormone activity [Term] id: GO:0070187 name: telosome namespace: cellular_component def: "A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex contains TRF1, TRF2, POT1, RAP1, TIN2 and TPP1 in mammalian cells, and Pot1, Tpz1, Ccq1, Poz1, and Rap1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1." [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880] synonym: "Pot1 complex" EXACT [GOC:vw] synonym: "Pot1-Tpz1 complex" EXACT [GOC:vw] synonym: "shelterin complex" EXACT [GOC:mah, GOC:vw] is_a: GO:0000783 ! nuclear telomere cap complex [Term] id: GO:0070188 name: Stn1-Ten1 complex namespace: cellular_component def: "A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present." [GOC:mah, GOC:vw, PMID:17715303, PMID:19064932] is_a: GO:0000783 ! nuclear telomere cap complex [Term] id: GO:0070189 name: kynurenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph] synonym: "kynurenine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0070190 name: inositol hexakisphosphate 1-kinase or 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179] is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0070191 name: methionine-R-sulfoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin." [GOC:mcc, PMID:17535911, PMID:19049972] xref: EC:1.8.4.- is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0070192 name: chromosome organization involved in meiosis namespace: biological_process def: "A process of chromosome organization that is involved in meiosis." [GOC:mah] synonym: "meiotic chromosome organization" EXACT [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0070193 name: synaptonemal complex organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis." [GOC:mah] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0070194 name: synaptonemal complex disassembly namespace: biological_process def: "The controlled breakdown of a synaptonemal complex." [GOC:mah] is_a: GO:0070193 ! synaptonemal complex organization is_a: GO:0071845 ! cellular component disassembly at cellular level [Term] id: GO:0070195 name: growth hormone receptor complex namespace: cellular_component def: "A receptor complex that consists of two identical subunits and binds growth hormone." [GOC:BHF, GOC:mah, GOC:vk, PMID:11445442] is_a: GO:0043235 ! receptor complex [Term] id: GO:0070196 name: eukaryotic translation initiation factor 3 complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex." [GOC:mah] synonym: "eIF-3 assembly" EXACT [GOC:mah] synonym: "eIF3 assembly" EXACT [GOC:mah] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0070197 name: attachment of telomeres to nuclear envelope namespace: biological_process def: "The cell cycle process in which physical connections are formed between telomeres and the nuclear envelope, facilitating bouquet formation." [GOC:jp, PMID:18818742] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0045141 ! meiotic telomere clustering [Term] id: GO:0070198 name: protein localization to chromosome, telomeric region namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome." [GOC:BHF, GOC:mah] synonym: "protein localisation to chromosome, telomeric region" EXACT [GOC:mah] synonym: "protein localization to telomere" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome [Term] id: GO:0070199 name: establishment of protein localization to chromosome namespace: biological_process def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0034502 ! protein localization to chromosome [Term] id: GO:0070200 name: establishment of protein localization to telomere namespace: biological_process def: "The directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] synonym: "establishment of protein localisation to telomere" EXACT [GOC:mah] synonym: "establishment of protein localization to chromosome, telomeric region" EXACT [GOC:mah] is_a: GO:0070199 ! establishment of protein localization to chromosome relationship: part_of GO:0070198 ! protein localization to chromosome, telomeric region [Term] id: GO:0070201 name: regulation of establishment of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization relationship: regulates GO:0045184 ! establishment of protein localization [Term] id: GO:0070202 name: regulation of establishment of protein localization to chromosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0070201 ! regulation of establishment of protein localization relationship: regulates GO:0070199 ! establishment of protein localization to chromosome [Term] id: GO:0070203 name: regulation of establishment of protein localization to telomere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation to telomere" EXACT [GOC:mah] is_a: GO:0070202 ! regulation of establishment of protein localization to chromosome relationship: regulates GO:0070200 ! establishment of protein localization to telomere [Term] id: GO:0070204 name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2)." [EC:2.2.1.9, RHEA:25596] comment: Note that this function was formerly EC:4.1.3.18. subset: gosubset_prok synonym: "MenD" RELATED [EC:2.2.1.9] synonym: "SEPHCHC synthase activity" EXACT [EC:2.2.1.9] xref: EC:2.2.1.9 xref: KEGG:R08165 xref: MetaCyc:2.5.1.64-RXN xref: RHEA:25596 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0070205 name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate." [EC:4.2.99.20, RHEA:25600] synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity" EXACT [EC:4.2.99.20] synonym: "6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity" EXACT [EC:4.2.99.20] synonym: "MenH" RELATED [EC:4.2.99.20] synonym: "SHCHC synthase activity" EXACT [EC:4.2.99.20] synonym: "YfbB" RELATED [EC:4.2.99.20] xref: EC:4.2.99.20 xref: KEGG:R08166 xref: MetaCyc:RXN-9310 xref: RHEA:25600 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0070206 name: protein trimerization namespace: biological_process def: "The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits." [GOC:hjd] subset: gosubset_prok synonym: "protein trimer assembly" EXACT [GOC:hjd] synonym: "protein trimer biosynthesis" EXACT [GOC:hjd] synonym: "protein trimer biosynthetic process" EXACT [GOC:hjd] synonym: "protein trimer formation" EXACT [GOC:hjd] is_a: GO:0051259 ! protein oligomerization [Term] id: GO:0070207 name: protein homotrimerization namespace: biological_process def: "The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits." [GOC:hjd] subset: gosubset_prok synonym: "protein homotrimer assembly" EXACT [GOC:hjd] synonym: "protein homotrimer biosynthesis" EXACT [GOC:hjd] synonym: "protein homotrimer biosynthetic process" EXACT [GOC:hjd] synonym: "protein homotrimer formation" EXACT [GOC:hjd] is_a: GO:0051260 ! protein homooligomerization is_a: GO:0070206 ! protein trimerization [Term] id: GO:0070208 name: protein heterotrimerization namespace: biological_process def: "The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical." [GOC:hjd] subset: gosubset_prok synonym: "protein heterotrimer assembly" EXACT [GOC:hjd] synonym: "protein heterotrimer biosynthesis" EXACT [GOC:hjd] synonym: "protein heterotrimer biosynthetic process" EXACT [GOC:hjd] synonym: "protein heterotrimer formation" EXACT [GOC:hjd] is_a: GO:0051291 ! protein heterooligomerization is_a: GO:0070206 ! protein trimerization [Term] id: GO:0070209 name: ASTRA complex namespace: cellular_component def: "A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p." [GOC:rb, PMID:19040720] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0070210 name: Rpd3L-Expanded complex namespace: cellular_component def: "A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720] synonym: "Clr6-LE complex" EXACT [GOC:vw] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0070211 name: Snt2C complex namespace: cellular_component def: "A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p." [GOC:rb, PMID:19040720] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0000790 ! nuclear chromatin [Term] id: GO:0070212 name: protein poly-ADP-ribosylation namespace: biological_process def: "The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain." [GOC:BHF, GOC:mah, GOC:rl] synonym: "addition of poly-ADP-ribose to protein" EXACT [GOC:rl] synonym: "poly(ADP-ribose) addition to protein" EXACT [GOC:rl] synonym: "protein amino acid poly-ADP-ribosylation" EXACT [GOC:bf] synonym: "protein poly(ADP-ribose) metabolism" RELATED [GOC:rl] synonym: "protein poly(ADP-ribose) synthesis" EXACT [GOC:rl] is_a: GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0070213 name: protein auto-ADP-ribosylation namespace: biological_process def: "The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GOC:BHF, GOC:rl] synonym: "protein amino acid auto-ADP-ribosylation" EXACT [GOC:bf] is_a: GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0070214 name: CSK-GAP-A.p62 complex namespace: cellular_component def: "A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation." [PMID:7544435] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0070215 name: MDM2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with any isoform of the MDM2 protein, a negative regulator of p53." [GOC:mah, GOC:nln] is_a: GO:0005515 ! protein binding [Term] id: GO:0070216 name: MDM4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with any isoform of the MDM4 protein, a negative regulator of p53." [GOC:mah, GOC:nln] synonym: "MDMX binding" EXACT [GOC:nln] is_a: GO:0005515 ! protein binding [Term] id: GO:0070217 name: transcription factor TFIIIB complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex." [GOC:mah] synonym: "TFIIIB assembly" EXACT [GOC:mah] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0070218 name: sulfide ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sulfide ions within an organism or cell." [GOC:mah] synonym: "sulfide generation" RELATED [GOC:mah] synonym: "sulfide homeostasis" EXACT [GOC:mah] synonym: "sulfide production" RELATED [GOC:mah] synonym: "sulphide generation" RELATED [GOC:mah] synonym: "sulphide homeostasis" EXACT [GOC:mah] synonym: "sulphide ion homeostasis" EXACT [GOC:mah] synonym: "sulphide production" RELATED [GOC:mah] is_a: GO:0055083 ! monovalent inorganic anion homeostasis [Term] id: GO:0070219 name: cellular sulfide ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sulfide ions at the level of a cell." [GOC:mah] synonym: "cellular sulfide homeostasis" EXACT [GOC:mah] synonym: "cellular sulphide homeostasis" EXACT [GOC:mah] synonym: "cellular sulphide ion homeostasis" EXACT [GOC:mah] is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis is_a: GO:0070218 ! sulfide ion homeostasis [Term] id: GO:0070220 name: aerobic sulfur oxidation namespace: biological_process def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen." [MetaCyc:SULFUROX-PWY] subset: gosubset_prok synonym: "aerobic sulphur oxidation" EXACT [GOC:mah] xref: MetaCyc:SULFUROX-PWY is_a: GO:0019417 ! sulfur oxidation [Term] id: GO:0070221 name: sulfide oxidation, using sulfide:quinone oxidoreductase namespace: biological_process def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase." [MetaCyc:P222-PWY] subset: gosubset_prok synonym: "sulfide oxidation, using sulfide-quinone reductase" EXACT [GOC:mah, MetaCyc:P222-PWY] synonym: "sulphide oxidation, using sulfide:quinone oxidoreductase" EXACT [GOC:mah] xref: MetaCyc:P222-PWY is_a: GO:0019418 ! sulfide oxidation [Term] id: GO:0070222 name: sulfide oxidation, using sulfide dehydrogenase namespace: biological_process def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase." [MetaCyc:PWY-5274] subset: gosubset_prok synonym: "sulphide oxidation, using sulfide dehydrogenase" EXACT [GOC:mah] xref: MetaCyc:PWY-5274 is_a: GO:0019418 ! sulfide oxidation [Term] id: GO:0070223 name: sulfide oxidation, using sulfur dioxygenase namespace: biological_process def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase." [MetaCyc:PWY-5285] subset: gosubset_prok synonym: "sulphide oxidation, using sulfur dioxygenase" EXACT [GOC:mah] xref: MetaCyc:PWY-5285 is_a: GO:0019418 ! sulfide oxidation [Term] id: GO:0070224 name: sulfide:quinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone." [MetaCyc:R17-RXN] subset: gosubset_prok synonym: "sulfide-quinone reductase activity" EXACT [MetaCyc:MONOMER-12314] synonym: "sulphide:quinone oxidoreductase activity" EXACT [GOC:mah] xref: EC:1.8.5.- xref: MetaCyc:R17-RXN is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [Term] id: GO:0070225 name: sulfide dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S0 + reduced cytochrome c." [MetaCyc:RXN-8156] subset: gosubset_prok synonym: "flavocytochrome c sulfide dehydrogenase activity" EXACT [MetaCyc:RXN-8156] synonym: "sulphide dehydrogenase activity" EXACT [GOC:mah] xref: EC:1.8.2.- xref: MetaCyc:RXN-8156 is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor [Term] id: GO:0070226 name: sulfur:ferric ion oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+." [MetaCyc:SULFFEOXIDO-RXN] subset: gosubset_prok synonym: "hydrogen sulfide:ferric ion oxidoreductase" EXACT [MetaCyc:SULFFEOXIDO-RXN] xref: MetaCyc:SULFFEOXIDO-RXN is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0070227 name: lymphocyte apoptosis namespace: biological_process def: "The process of apoptosis in a lymphocyte." [GOC:add, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). is_a: GO:0071887 ! leukocyte apoptosis [Term] id: GO:0070228 name: regulation of lymphocyte apoptosis namespace: biological_process def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). is_a: GO:2000106 ! regulation of leukocyte apoptosis relationship: regulates GO:0070227 ! lymphocyte apoptosis [Term] id: GO:0070229 name: negative regulation of lymphocyte apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptosis is_a: GO:2000107 ! negative regulation of leukocyte apoptosis relationship: negatively_regulates GO:0070227 ! lymphocyte apoptosis [Term] id: GO:0070230 name: positive regulation of lymphocyte apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add] synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add] synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptosis is_a: GO:2000108 ! positive regulation of leukocyte apoptosis relationship: positively_regulates GO:0070227 ! lymphocyte apoptosis [Term] id: GO:0070231 name: T cell apoptosis namespace: biological_process def: "The process of apoptosis in a T cell." [GOC:add, ISBN:0781765196] synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "T lymphocyte apoptosis" EXACT [GOC:add] synonym: "T-cell apoptosis" EXACT [GOC:add] synonym: "T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070227 ! lymphocyte apoptosis [Term] id: GO:0070232 name: regulation of T cell apoptosis namespace: biological_process def: "Any process that modulates the occurrence or rate of T cell death by apoptosis." [GOC:add, ISBN:0781765196] synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptosis relationship: regulates GO:0070231 ! T cell apoptosis [Term] id: GO:0070233 name: negative regulation of T cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptosis." [GOC:add, ISBN:0781765196] synonym: "down regulation of T cell apoptosis" EXACT [GOC:add] synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add] synonym: "downregulation of T cell apoptosis" EXACT [GOC:add] synonym: "inhibition of T cell apoptosis" NARROW [GOC:add] synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070229 ! negative regulation of lymphocyte apoptosis is_a: GO:0070232 ! regulation of T cell apoptosis relationship: negatively_regulates GO:0070231 ! T cell apoptosis [Term] id: GO:0070234 name: positive regulation of T cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptosis." [GOC:add, ISBN:0781765196] synonym: "activation of T cell apoptosis" NARROW [GOC:add] synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add] synonym: "stimulation of T cell apoptosis" NARROW [GOC:add] synonym: "up regulation of T cell apoptosis" EXACT [GOC:add] synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add] synonym: "upregulation of T cell apoptosis" EXACT [GOC:add] is_a: GO:0070230 ! positive regulation of lymphocyte apoptosis is_a: GO:0070232 ! regulation of T cell apoptosis relationship: positively_regulates GO:0070231 ! T cell apoptosis [Term] id: GO:0070235 name: regulation of activation-induced cell death of T cells namespace: biological_process def: "Any process that modulates the occurrence or rate of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196] synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "regulation of activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "regulation of AICD" BROAD [GOC:add] synonym: "regulation of antigen-driven apoptosis" BROAD [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0070232 ! regulation of T cell apoptosis relationship: regulates GO:0006924 ! activation-induced cell death of T cells [Term] id: GO:0070236 name: negative regulation of activation-induced cell death of T cells namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196] synonym: "down regulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "down-regulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "downregulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "inhibition of activation-induced cell death of T cells" NARROW [GOC:add] synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "negative regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "negative regulation of activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "negative regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "negative regulation of AICD" BROAD [GOC:add] synonym: "negative regulation of antigen-driven apoptosis" BROAD [] is_a: GO:0070233 ! negative regulation of T cell apoptosis is_a: GO:0070235 ! regulation of activation-induced cell death of T cells relationship: negatively_regulates GO:0006924 ! activation-induced cell death of T cells [Term] id: GO:0070237 name: positive regulation of activation-induced cell death of T cells namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196] synonym: "activation of activation-induced cell death of T cells" NARROW [GOC:add] synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "positive regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "positive regulation of activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "positive regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "positive regulation of AICD" BROAD [GOC:add] synonym: "positive regulation of antigen-driven apoptosis" BROAD [GOC:add] synonym: "stimulation of activation-induced cell death of T cells" NARROW [GOC:add] synonym: "up regulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "up-regulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "upregulation of activation-induced cell death of T cells" EXACT [GOC:add] is_a: GO:0070234 ! positive regulation of T cell apoptosis is_a: GO:0070235 ! regulation of activation-induced cell death of T cells relationship: positively_regulates GO:0006924 ! activation-induced cell death of T cells [Term] id: GO:0070238 name: activated T cell autonomous cell death namespace: biological_process def: "A type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products." [GOC:add, ISBN:0781765196] synonym: "ACAD" BROAD [GOC:add] synonym: "activated cell autonomous cell death" BROAD [GOC:add] synonym: "activated T cell apoptosis" BROAD [GOC:add] synonym: "activated T lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "activated T-cell autonomous cell death" EXACT [GOC:add] synonym: "activated T-lymphocyte autonomous cell death" EXACT [GOC:add] is_a: GO:0070231 ! T cell apoptosis relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0070239 name: regulation of activated T cell autonomous cell death namespace: biological_process def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196] synonym: "regulation of ACAD" BROAD [GOC:add] synonym: "regulation of activated cell autonomous cell death" BROAD [GOC:add] synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "regulation of activated T-cell autonomous cell death" EXACT [GOC:add] synonym: "regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0070232 ! regulation of T cell apoptosis relationship: regulates GO:0070238 ! activated T cell autonomous cell death [Term] id: GO:0070240 name: negative regulation of activated T cell autonomous cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196] synonym: "down regulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "down-regulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "downregulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "inhibition of activated T cell autonomous cell death" NARROW [GOC:add] synonym: "negative regulation of ACAD" BROAD [GOC:add] synonym: "negative regulation of activated cell autonomous cell death" BROAD [GOC:add] synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "negative regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "negative regulation of activated T-cell autonomous cell death" EXACT [GOC:add] synonym: "negative regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add] is_a: GO:0070233 ! negative regulation of T cell apoptosis is_a: GO:0070239 ! regulation of activated T cell autonomous cell death relationship: negatively_regulates GO:0070238 ! activated T cell autonomous cell death [Term] id: GO:0070241 name: positive regulation of activated T cell autonomous cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196] synonym: "activation of activated T cell autonomous cell death" NARROW [GOC:add] synonym: "positive regulation of ACAD" BROAD [GOC:add] synonym: "positive regulation of activated cell autonomous cell death" BROAD [GOC:add] synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "positive regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "positive regulation of activated T-cell autonomous cell death" EXACT [GOC:add] synonym: "positive regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "stimulation of activated T cell autonomous cell death" NARROW [GOC:add] synonym: "up regulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "up-regulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "upregulation of activated T cell autonomous cell death" EXACT [GOC:add] is_a: GO:0070234 ! positive regulation of T cell apoptosis is_a: GO:0070239 ! regulation of activated T cell autonomous cell death relationship: positively_regulates GO:0070238 ! activated T cell autonomous cell death [Term] id: GO:0070242 name: thymocyte apoptosis namespace: biological_process def: "The process of apoptosis in a thymocyte." [GOC:add, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "immature T cell apoptosis" RELATED [GOC:add] is_a: GO:0070231 ! T cell apoptosis [Term] id: GO:0070243 name: regulation of thymocyte apoptosis namespace: biological_process def: "Any process that modulates the occurrence or rate of thymocyte death by apoptosis." [GOC:add, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "regulation of immature T cell apoptosis" RELATED [GOC:add] is_a: GO:0070232 ! regulation of T cell apoptosis relationship: regulates GO:0070242 ! thymocyte apoptosis [Term] id: GO:0070244 name: negative regulation of thymocyte apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptosis." [GOC:add, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "down regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "down-regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "downregulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "inhibition of thymocyte apoptosis" NARROW [GOC:add] synonym: "negative regulation of immature T cell apoptosis" RELATED [GOC:add] is_a: GO:0070233 ! negative regulation of T cell apoptosis is_a: GO:0070243 ! regulation of thymocyte apoptosis relationship: negatively_regulates GO:0070242 ! thymocyte apoptosis [Term] id: GO:0070245 name: positive regulation of thymocyte apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptosis." [GOC:add, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "activation of thymocyte apoptosis" NARROW [GOC:add] synonym: "positive regulation of immature T cell apoptosis" RELATED [GOC:add] synonym: "stimulation of thymocyte apoptosis" NARROW [GOC:add] synonym: "up regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "up-regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "upregulation of thymocyte apoptosis" EXACT [GOC:add] is_a: GO:0070234 ! positive regulation of T cell apoptosis is_a: GO:0070243 ! regulation of thymocyte apoptosis relationship: positively_regulates GO:0070242 ! thymocyte apoptosis [Term] id: GO:0070246 name: natural killer cell apoptosis namespace: biological_process def: "The process of apoptosis in a natural killer cell." [GOC:add, PMID:15728472] synonym: "NK cell apoptosis" EXACT [GOC:add] is_a: GO:0070227 ! lymphocyte apoptosis [Term] id: GO:0070247 name: regulation of natural killer cell apoptosis namespace: biological_process def: "Any process that modulates the occurrence or rate of natural killer cell death by apoptosis." [GOC:add, ISBN:0781765196] synonym: "regulation of NK cell apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptosis relationship: regulates GO:0070246 ! natural killer cell apoptosis [Term] id: GO:0070248 name: negative regulation of natural killer cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell death by apoptosis." [GOC:add, ISBN:0781765196] synonym: "down regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "down-regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "downregulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "inhibition of natural killer cell apoptosis" NARROW [GOC:add] synonym: "negative regulation of NK cell apoptosis" EXACT [GOC:add] is_a: GO:0070229 ! negative regulation of lymphocyte apoptosis is_a: GO:0070247 ! regulation of natural killer cell apoptosis relationship: negatively_regulates GO:0070246 ! natural killer cell apoptosis [Term] id: GO:0070249 name: positive regulation of natural killer cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptosis." [GOC:add, ISBN:0781765196] synonym: "activation of natural killer cell apoptosis" NARROW [GOC:add] synonym: "positive regulation of NK cell apoptosis" EXACT [GOC:add] synonym: "stimulation of natural killer cell apoptosis" NARROW [GOC:add] synonym: "up regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "up-regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "upregulation of natural killer cell apoptosis" EXACT [GOC:add] is_a: GO:0070230 ! positive regulation of lymphocyte apoptosis is_a: GO:0070247 ! regulation of natural killer cell apoptosis relationship: positively_regulates GO:0070246 ! natural killer cell apoptosis [Term] id: GO:0070250 name: mating projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone." [GOC:jp] synonym: "shmoo membrane" NARROW [GOC:jp] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0070251 name: pristanate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA." [GOC:pde, PMID:10198260] subset: gosubset_prok synonym: "pristanate:CoA ligase (AMP-forming)" EXACT [GOc:mah] synonym: "pristanoyl-CoA ligase activity" EXACT [GOC:mah] xref: EC:6.2.1.- xref: Reactome:389766 "pristanate-CoA ligase activity" is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0070252 name: actin-mediated cell contraction namespace: biological_process def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0070253 name: somatostatin secretion namespace: biological_process def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070254 name: mucus secretion namespace: biological_process def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544] synonym: "mucus production" EXACT [GOC:add] is_a: GO:0007589 ! body fluid secretion [Term] id: GO:0070255 name: regulation of mucus secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or group of cells." [GOC:add] synonym: "regulation of mucus production" EXACT [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0070254 ! mucus secretion [Term] id: GO:0070256 name: negative regulation of mucus secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or group of cells." [GOC:add] synonym: "negative regulation of mucus production" EXACT [GOC:add] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070255 ! regulation of mucus secretion relationship: negatively_regulates GO:0070254 ! mucus secretion [Term] id: GO:0070257 name: positive regulation of mucus secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or group of cells." [GOC:add] synonym: "positive regulation of mucus production" EXACT [GOC:add] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070255 ! regulation of mucus secretion relationship: positively_regulates GO:0070254 ! mucus secretion [Term] id: GO:0070258 name: inner membrane complex namespace: cellular_component def: "A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell." [GOC:mah, PMID:12456714] is_a: GO:0044464 ! cell part relationship: part_of GO:0020039 ! pellicle [Term] id: GO:0070259 name: tyrosyl-DNA phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA." [GOC:elh, PMID:16751265] comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0070260 name: 5'-tyrosyl-DNA phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA." [PMID:16751265] comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity [Term] id: GO:0070262 name: peptidyl-serine dephosphorylation namespace: biological_process def: "The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine." [GOC:bf] is_a: GO:0006470 ! protein dephosphorylation [Term] id: GO:0070263 name: external side of fungal-type cell wall namespace: cellular_component def: "The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents." [GOC:mah] is_a: GO:0010339 ! external side of cell wall relationship: part_of GO:0009277 ! fungal-type cell wall [Term] id: GO:0070264 name: transcription factor TFIIIE complex namespace: cellular_component def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins." [GOC:jp, PMID:19116144] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0070265 name: necrotic cell death namespace: biological_process def: "A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:18846107] comment: Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals. synonym: "cellular necrosis" EXACT [GOC:add] synonym: "necrosis" BROAD [GOC:mah] is_a: GO:0008219 ! cell death [Term] id: GO:0070266 name: necroptosis namespace: biological_process def: "A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:mah, PMID:18846107] synonym: "programmed necrotic cell death" EXACT [GOC:mah] is_a: GO:0070265 ! necrotic cell death [Term] id: GO:0070267 name: oncosis namespace: biological_process def: "A cellular process that results in swelling of the cell body, and that is morphologically characteristic of necrotic cell death." [PMID:17873035, PMID:18846107] comment: Note that oncosis is sometimes described as a type of cell death, but recent nomenclature recommendations define it as a feature of necrotic cell death rather than a distinct mode of cell death. is_a: GO:0045793 ! positive regulation of cell size relationship: part_of GO:0070265 ! necrotic cell death [Term] id: GO:0070268 name: cornification namespace: biological_process def: "A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability)." [PMID:18846107] is_a: GO:0012501 ! programmed cell death relationship: part_of GO:0031424 ! keratinization [Term] id: GO:0070269 name: pyroptosis namespace: biological_process def: "A type of programmed cell death that results from the apical activation of caspase-1." [PMID:18846107] is_a: GO:0012501 ! programmed cell death [Term] id: GO:0070270 name: mitotic catastrophe namespace: biological_process def: "A type of programmed cell death that occurs during or shortly after a dysregulated or failed mitosis and can be accompanied by morphological alterations including micronucleation and multinucleation." [PMID:18846107] synonym: "cell death occurring during metaphase" RELATED [PMID:18846107] synonym: "cell death preceded by multinucleation" RELATED [PMID:18846107] is_a: GO:0012501 ! programmed cell death [Term] id: GO:0070271 name: protein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex." [GOC:mah] subset: goslim_yeast subset: gosubset_prok synonym: "protein complex biogenesis and assembly" EXACT [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0070272 name: proton-transporting ATP synthase complex biogenesis namespace: biological_process def: "The biogenesis of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mah, PMID:19103153] synonym: "F-type ATPase complex biogenesis" EXACT [GOC:mah] is_a: GO:0070271 ! protein complex biogenesis is_a: GO:0071843 ! cellular component biogenesis at cellular level [Term] id: GO:0070273 name: phosphatidylinositol-4-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0070274 name: RES complex namespace: cellular_component def: "A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p." [PMID:15565172, PMID:18809678, PMID:19010333, PMID:19033360] synonym: "pre-mRNA retention and splicing complex" EXACT [GOC:sre] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070275 name: aerobic ammonia oxidation to nitrite via pyruvic oxime namespace: biological_process def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite." [MetaCyc:PWY-2242] subset: gosubset_prok xref: MetaCyc:PWY-2242 is_a: GO:0019329 ! ammonia oxidation [Term] id: GO:0070276 name: halogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [CHEBI:22473, GOC:mah] synonym: "halogen metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0070277 name: iodide oxidation namespace: biological_process def: "The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons." [GOC:mah, MetaCyc:IODIDE-PEROXIDASE-RXN] is_a: GO:0055114 ! oxidation-reduction process is_a: GO:0070276 ! halogen metabolic process [Term] id: GO:0070278 name: extracellular matrix constituent secretion namespace: biological_process def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:mah] synonym: "ECM constituent secretion" EXACT [GOC:mah] synonym: "ECM secretion" EXACT [GOC:mah] is_a: GO:0032940 ! secretion by cell relationship: part_of GO:0030198 ! extracellular matrix organization [Term] id: GO:0070279 name: vitamin B6 binding namespace: molecular_function def: "Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah] is_a: GO:0019842 ! vitamin binding [Term] id: GO:0070280 name: pyridoxal binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah] is_a: GO:0070279 ! vitamin B6 binding [Term] id: GO:0070281 name: pyridoxamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16410, GOC:mah] is_a: GO:0070279 ! vitamin B6 binding [Term] id: GO:0070282 name: pyridoxine binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16709, GOC:mah] is_a: GO:0070279 ! vitamin B6 binding [Term] id: GO:0070283 name: radical SAM enzyme activity namespace: molecular_function def: "Catalysis of a reaction in which S-adenosyl-L-methionine (SAM) undergoes reductive cleavage to serve as a source of the 5'-deoxyadenosyl radical." [PMID:17291766, PMID:18307109] xref: Reactome:396401 "radical SAM enzyme activity" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0070284 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine." [PMID:18953358] synonym: "HMP-P synthase activity" EXACT [PMID:18953358] synonym: "ThiC" RELATED [PMID:18953358] is_a: GO:0016853 ! isomerase activity is_a: GO:0070283 ! radical SAM enzyme activity [Term] id: GO:0070285 name: pigment cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs] is_a: GO:0048468 ! cell development relationship: part_of GO:0050931 ! pigment cell differentiation [Term] id: GO:0070286 name: axonemal dynein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:mah, PMID:19052621] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0070287 name: ferritin receptor activity namespace: molecular_function def: "Combining with ferritin, an iron-storing protein complex, to initiate a change in cell activity." [GOC:mah, PMID:17459943, PMID:19154717] synonym: "ferritin complex receptor activity" EXACT [GOC:mah] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0070288 name: ferritin complex namespace: cellular_component def: "A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain." [GOC:mah, PMID:19154717] is_a: GO:0043234 ! protein complex [Term] id: GO:0070289 name: extracellular ferritin complex namespace: cellular_component def: "A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains." [GOC:mah, PMID:19154717] synonym: "serum ferritin complex" RELATED [PMID:19154717] is_a: GO:0044421 ! extracellular region part is_a: GO:0070288 ! ferritin complex [Term] id: GO:0070290 name: NAPE-specific phospholipase D activity namespace: molecular_function def: "Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693] xref: EC:3.1.4.4 is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0070291 name: N-acylethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group." [CHEBI:52640, GOC:elh, PMID:14634025, PMID:15878693] synonym: "N-acylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693] synonym: "NAE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15877693] synonym: "NAE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693] is_a: GO:0042439 ! ethanolamine-containing compound metabolic process [Term] id: GO:0070292 name: N-acylphosphatidylethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group." [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693] synonym: "N-acylphosphatidylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693] synonym: "NAPE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15877693] synonym: "NAPE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693] is_a: GO:0046337 ! phosphatidylethanolamine metabolic process [Term] id: GO:0070293 name: renal absorption namespace: biological_process def: "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron." [GOC:dph, GOC:mah, GOC:yaf] synonym: "nephron absorption" EXACT [GOC:mah] synonym: "renal reabsorption" EXACT [GOC:dph] is_a: GO:0003014 ! renal system process [Term] id: GO:0070294 name: renal sodium ion absorption namespace: biological_process def: "A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron." [GOC:dph, GOC:mah] synonym: "nephron sodium ion absorption" EXACT [GOC:mah] synonym: "renal sodium ion reabsorption" EXACT [GOC:dph] is_a: GO:0003096 ! renal sodium ion transport is_a: GO:0070293 ! renal absorption [Term] id: GO:0070295 name: renal water absorption namespace: biological_process def: "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron." [GOC:dph, GOC:mah] synonym: "nephron water absorption" EXACT [GOC:mah] synonym: "renal water reabsorption" EXACT [GOC:dph] is_a: GO:0003097 ! renal water transport is_a: GO:0070293 ! renal absorption [Term] id: GO:0070296 name: sarcoplasmic reticulum calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum." [GOC:vk] is_a: GO:0006816 ! calcium ion transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0070297 name: regulation of two-component signal transduction system (phosphorelay) namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction via a two-component phosphorelay signal transduction system." [GOC:mah] subset: gosubset_prok synonym: "regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah] synonym: "regulation of two-component signal transduction system (phosphorelay)" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0000160 ! two-component signal transduction system (phosphorelay) [Term] id: GO:0070298 name: negative regulation of two-component signal transduction system (phosphorelay) namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a two-component phosphorelay signal transduction system." [GOC:mah] synonym: "down regulation of two-component signal transduction" EXACT [GOC:mah] synonym: "down-regulation of two-component signal transduction" EXACT [GOC:mah] synonym: "downregulation of two-component signal transduction" EXACT [GOC:mah] synonym: "inhibition of two-component signal transduction" NARROW [GOC:mah] synonym: "negative regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah] synonym: "negative regulation of two-component signal transduction system (phosphorelay)" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0070297 ! regulation of two-component signal transduction system (phosphorelay) relationship: negatively_regulates GO:0000160 ! two-component signal transduction system (phosphorelay) [Term] id: GO:0070299 name: positive regulation of two-component signal transduction system (phosphorelay) namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction via a two-component phosphorelay signal transduction system." [GOC:mah] synonym: "activation of two-component signal transduction" NARROW [GOC:mah] synonym: "positive regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah] synonym: "positive regulation of two-component signal transduction system (phosphorelay)" EXACT [GOC:mah] synonym: "stimulation of two-component signal transduction" NARROW [GOC:mah] synonym: "up regulation of two-component signal transduction" EXACT [GOC:mah] synonym: "up-regulation of two-component signal transduction" EXACT [GOC:mah] synonym: "upregulation of two-component signal transduction" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0070297 ! regulation of two-component signal transduction system (phosphorelay) relationship: positively_regulates GO:0000160 ! two-component signal transduction system (phosphorelay) [Term] id: GO:0070300 name: phosphatidic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [CHEBI:16337, GOC:jp, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "phosphatidate binding" EXACT [GOC:jp] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0070301 name: cellular response to hydrogen peroxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [CHEBI:16240, GOC:mah] is_a: GO:0034614 ! cellular response to reactive oxygen species is_a: GO:0042542 ! response to hydrogen peroxide [Term] id: GO:0070302 name: regulation of stress-activated protein kinase signaling cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade." [GOC:mah] synonym: "regulation of SAPK signaling pathway" EXACT [GOC:mah] synonym: "regulation of stress-activated protein kinase signaling pathway" EXACT [] synonym: "regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0010627 ! regulation of intracellular protein kinase cascade is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0070303 name: negative regulation of stress-activated protein kinase signaling cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah] synonym: "down regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "down-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "downregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "inhibition of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] synonym: "negative regulation of SAPK signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of stress-activated protein kinase signaling pathway" EXACT [] synonym: "negative regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0010741 ! negative regulation of intracellular protein kinase cascade is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade relationship: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0070304 name: positive regulation of stress-activated protein kinase signaling cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah] synonym: "activation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] synonym: "positive regulation of SAPK signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of stress-activated protein kinase signaling pathway" EXACT [] synonym: "positive regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] synonym: "stimulation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] synonym: "up regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "up-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "upregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] is_a: GO:0010740 ! positive regulation of intracellular protein kinase cascade is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade relationship: positively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0070305 name: response to cGMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:sl] synonym: "response to 3',5' cGMP" EXACT [GOC:mah] synonym: "response to 3',5'-cGMP" EXACT [GOC:mah] synonym: "response to cyclic GMP" EXACT [GOC:mah] synonym: "response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0070306 name: lens fiber cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities." [GOC:mah, PMID:7693735] synonym: "lens fibre cell differentiation" EXACT [GOC:mah] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0002088 ! lens development in camera-type eye [Term] id: GO:0070307 name: lens fiber cell development namespace: biological_process def: "The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] synonym: "lens fibre cell development" EXACT [GOC:mah] is_a: GO:0048468 ! cell development relationship: part_of GO:0070306 ! lens fiber cell differentiation [Term] id: GO:0070308 name: lens fiber cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] synonym: "lens fibre cell fate commitment" EXACT [GOC:mah] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0070306 ! lens fiber cell differentiation [Term] id: GO:0070309 name: lens fiber cell morphogenesis namespace: biological_process def: "The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] synonym: "elongation of lens fiber cell" NARROW [GOC:mah, GOC:vk] synonym: "lens fiber cell morphogenesis during differentiation" EXACT systematic_synonym [GOC:mah] synonym: "lens fibre cell morphogenesis" EXACT [GOC:mah] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye relationship: part_of GO:0070307 ! lens fiber cell development [Term] id: GO:0070310 name: ATR-ATRIP complex namespace: cellular_component def: "A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A." [GOC:mah, PMID:14724280] synonym: "Mec1-Lcd1 complex" NARROW [PMID:17339343] synonym: "Rad3-Rad26 complex" NARROW [PMID:17339343] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070311 name: nucleosomal methylation activator complex namespace: cellular_component def: "A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription." [GOC:mah, PMID:14729568] synonym: "NUMAC" EXACT [PMID:14729568] is_a: GO:0016585 ! chromatin remodeling complex is_a: GO:0035097 ! histone methyltransferase complex [Term] id: GO:0070312 name: RAD52-ERCC4-ERCC1 complex namespace: cellular_component def: "A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein." [PMID:14734547] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0070313 name: RGS6-DNMT1-DMAP1 complex namespace: cellular_component def: "A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1." [GOC:mah, PMID:14734556] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070314 name: G1 to G0 transition namespace: biological_process def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence." [GOC:mah, ISBN:0815316194] synonym: "cell cycle quiescence" RELATED [GOC:mah] synonym: "establishment of cell quiescence" EXACT [GOC:mah] synonym: "G1/G0 transition" EXACT [GOC:mah] synonym: "stationary phase" RELATED [GOC:mah] is_a: GO:0007050 ! cell cycle arrest [Term] id: GO:0070315 name: G1 to G0 transition involved in cell differentiation namespace: biological_process def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation." [GOC:mah, ISBN:0815316194] synonym: "G1/G0 transition involved in cell differentiation" EXACT [GOC:mah] is_a: GO:0070314 ! G1 to G0 transition relationship: part_of GO:0030154 ! cell differentiation [Term] id: GO:0070316 name: regulation of G0 to G1 transition namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process relationship: regulates GO:0045023 ! G0 to G1 transition [Term] id: GO:0070317 name: negative regulation of G0 to G1 transition namespace: biological_process def: "A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] synonym: "maintenance of cell cycle quiescence" EXACT [GOC:mah] synonym: "maintenance of cell quiescence" EXACT [GOC:mah] synonym: "maintenance of G0 arrest" EXACT [GOC:mah] synonym: "maintenance of G0 phase" EXACT [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0070316 ! regulation of G0 to G1 transition relationship: negatively_regulates GO:0045023 ! G0 to G1 transition [Term] id: GO:0070318 name: positive regulation of G0 to G1 transition namespace: biological_process def: "A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0070316 ! regulation of G0 to G1 transition is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0045023 ! G0 to G1 transition [Term] id: GO:0070319 name: Golgi to plasma membrane transport vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] synonym: "Golgi-plasma membrane transport vesicle" EXACT [GOC:mah] is_a: GO:0070382 ! exocytic vesicle [Term] id: GO:0070320 name: inward rectifier potassium channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of an inwardly rectifying potassium channel." [GOC:mah] is_a: GO:0019870 ! potassium channel inhibitor activity [Term] id: GO:0070321 name: regulation of translation in response to nitrogen starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] is_a: GO:0006995 ! cellular response to nitrogen starvation is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0070322 name: negative regulation of translation in response to nitrogen starvation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] synonym: "down regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "down-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "downregulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "inhibition of translation in response to nitrogen starvation" NARROW [GOC:mah] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0070321 ! regulation of translation in response to nitrogen starvation [Term] id: GO:0070323 name: positive regulation of translation in response to nitrogen starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] synonym: "activation of translation in response to nitrogen starvation" NARROW [GOC:mah] synonym: "stimulation of translation in response to nitrogen starvation" NARROW [GOC:mah] synonym: "up regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "up-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "upregulation of translation in response to nitrogen starvation" EXACT [GOC:mah] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0070321 ! regulation of translation in response to nitrogen starvation [Term] id: GO:0070324 name: thyroid hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland." [GOC:rph] synonym: "thyroxine binding" NARROW [GOC:mah] synonym: "triiodothyronine binding" NARROW [GOC:mah] is_a: GO:0042562 ! hormone binding [Term] id: GO:0070325 name: lipoprotein particle receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipoprotein particle receptor." [GOC:BHF, GOC:rl] is_a: GO:0005102 ! receptor binding [Term] id: GO:0070326 name: very-low-density lipoprotein particle receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a very-low-density lipoprotein receptor." [GOC:BHF, GOC:mah] synonym: "apolipoprotein E receptor binding" RELATED [GOC:rl] synonym: "very-low-density lipoprotein particle receptor binding" EXACT [GOC:dph] synonym: "VLDL receptor binding" EXACT [GOC:mah] synonym: "VLDLR binding" EXACT [GOC:mah] is_a: GO:0070325 ! lipoprotein particle receptor binding [Term] id: GO:0070327 name: thyroid hormone transport namespace: biological_process def: "The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:rph] synonym: "thyroxine transport" NARROW [GOC:mah] synonym: "triiodothyronine transport" NARROW [GOC:mah] is_a: GO:0009914 ! hormone transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0070328 name: triglyceride homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] synonym: "triacylglycerol homeostasis" EXACT [GOC:rl] is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0070329 name: tRNA seleno-modification namespace: biological_process def: "The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule." [GOC:jsg, PMID:14594807] subset: gosubset_prok synonym: "tRNA base modification to selenouridine" EXACT [GOC:mah] is_a: GO:0001887 ! selenium compound metabolic process is_a: GO:0006400 ! tRNA modification [Term] id: GO:0070330 name: aromatase activity namespace: molecular_function def: "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] subset: gosubset_prok synonym: "estrogen synthetase activity" NARROW [] xref: EC:1.14.14.1 xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0551 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0070331 name: CD20-Lck-Fyn complex namespace: cellular_component def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn." [GOC:mah, PMID:7545683] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0070332 name: CD20-Lck-Lyn-Fyn complex namespace: cellular_component def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn." [GOC:mah, PMID:7545683] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0070333 name: alpha6-beta4 integrin-Shc-Grb2 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2." [PMID:7556090] synonym: "ITGA6-ITGB4-SHC-GRB2 complex" NARROW [CORUM:3096] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070334 name: alpha6-beta4 integrin-laminin 5 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5." [GOC:mah, PMID:7556090] synonym: "ITGA6-ITGB4-LAMA5 complex" NARROW [CORUM:2322] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070335 name: aspartate binding namespace: molecular_function def: "Interacting selectively and non-covalently with glutamate, the anion of 2-aminobutanedioic acid." [GOC:mah] synonym: "aspartic acid binding" EXACT [GOC:mah] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0070336 name: flap-structured DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154] subset: gosubset_prok is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0070337 name: 3'-flap-structured DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154] subset: gosubset_prok is_a: GO:0070336 ! flap-structured DNA binding [Term] id: GO:0070338 name: 5'-flap-structured DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers." [GOC:mah, PMID:15189154] subset: gosubset_prok is_a: GO:0070336 ! flap-structured DNA binding [Term] id: GO:0070339 name: response to bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:add, PMID:12077222] is_a: GO:0032493 ! response to bacterial lipoprotein [Term] id: GO:0070340 name: detection of bacterial lipopeptide namespace: biological_process def: "The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal." [GOC:add, PMID:12077222] is_a: GO:0042494 ! detection of bacterial lipoprotein is_a: GO:0070339 ! response to bacterial lipopeptide [Term] id: GO:0070341 name: fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl] synonym: "adipocyte proliferation" EXACT [GOC:sl] synonym: "adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0070342 name: brown fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species." [CL:0000449, GOC:mah, GOC:sl] synonym: "brown adipocyte proliferation" EXACT [GOC:sl] synonym: "brown adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070341 ! fat cell proliferation [Term] id: GO:0070343 name: white fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population." [CL:0000448, GOC:mah, GOC:sl] synonym: "white adipocyte proliferation" EXACT [GOC:sl] synonym: "white adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070341 ! fat cell proliferation [Term] id: GO:0070344 name: regulation of fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0070341 ! fat cell proliferation [Term] id: GO:0070345 name: negative regulation of fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0070344 ! regulation of fat cell proliferation relationship: negatively_regulates GO:0070341 ! fat cell proliferation [Term] id: GO:0070346 name: positive regulation of fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0070344 ! regulation of fat cell proliferation relationship: positively_regulates GO:0070341 ! fat cell proliferation [Term] id: GO:0070347 name: regulation of brown fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of brown adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of brown adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070344 ! regulation of fat cell proliferation relationship: regulates GO:0070342 ! brown fat cell proliferation [Term] id: GO:0070348 name: negative regulation of brown fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of brown fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of brown adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of brown adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070345 ! negative regulation of fat cell proliferation is_a: GO:0070347 ! regulation of brown fat cell proliferation relationship: negatively_regulates GO:0070342 ! brown fat cell proliferation [Term] id: GO:0070349 name: positive regulation of brown fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of brown fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of brown adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of brown adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of brown fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of brown fat cell proliferation" EXACT [GOC:mah] is_a: GO:0070346 ! positive regulation of fat cell proliferation is_a: GO:0070347 ! regulation of brown fat cell proliferation relationship: positively_regulates GO:0070342 ! brown fat cell proliferation [Term] id: GO:0070350 name: regulation of white fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of white adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of white adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070344 ! regulation of fat cell proliferation relationship: regulates GO:0070343 ! white fat cell proliferation [Term] id: GO:0070351 name: negative regulation of white fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of white fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of white adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of white adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070345 ! negative regulation of fat cell proliferation is_a: GO:0070350 ! regulation of white fat cell proliferation relationship: negatively_regulates GO:0070343 ! white fat cell proliferation [Term] id: GO:0070352 name: positive regulation of white fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of white fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of white adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of white adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of white fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of white fat cell proliferation" EXACT [GOC:mah] is_a: GO:0070346 ! positive regulation of fat cell proliferation is_a: GO:0070350 ! regulation of white fat cell proliferation relationship: positively_regulates GO:0070343 ! white fat cell proliferation [Term] id: GO:0070353 name: GATA1-TAL1-TCF3-Lmo2 complex namespace: cellular_component def: "A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070354 name: GATA2-TAL1-TCF3-Lmo2 complex namespace: cellular_component def: "A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070355 name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex namespace: cellular_component def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof)." [PMID:7654227] synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)" NARROW [CORUM:1247] synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex" NARROW [CORUM:1247] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070356 name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex namespace: cellular_component def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof)." [PMID:7654227] synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)" NARROW [CORUM:1244] synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex" NARROW [CORUM:1244] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070357 name: alphav-beta3 integrin-CD47 complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP)." [PMID:2277087, PMID:7691831] synonym: "ITGB3-ITGAV-CD47 complex" NARROW [CORUM:2356] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070358 name: actin polymerization-dependent cell motility namespace: biological_process def: "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell." [GOC:mah, PMID:15773977] subset: gosubset_prok synonym: "cell motility by actin tail formation" EXACT [PMID:15773977] is_a: GO:0048870 ! cell motility [Term] id: GO:0070359 name: actin polymerization-dependent cell motility involved in migration of symbiont in host namespace: biological_process def: "A process involved in the controlled movement of a bacterial cell within a host cell, powered by the continuous polymerization of host actin at one pole of the cell." [GOC:jl, GOC:mah, PMID:15773977] subset: gosubset_prok synonym: "actin polymerization-dependent cell motility involved in migration of symbiont within host" EXACT [] is_a: GO:0070358 ! actin polymerization-dependent cell motility relationship: part_of GO:0070360 ! migration of symbiont within host by polymerization of host actin [Term] id: GO:0070360 name: migration of symbiont within host by polymerization of host actin namespace: biological_process def: "The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of host actin at one pole of the symbiont cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mah] subset: gosubset_prok is_a: GO:0044001 ! migration in host [Term] id: GO:0070361 name: mitochondrial light strand promoter anti-sense binding namespace: molecular_function def: "Interacting selectively and non-covalently with the anti-sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "LSP non-coding strand binding" EXACT [PMID:9485316] synonym: "LSPas binding" EXACT [PMID:9485316] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0070362 name: mitochondrial heavy strand promoter anti-sense binding namespace: molecular_function def: "Interacting selectively and non-covalently with the anti-sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "HSP non-coding strand binding" EXACT [PMID:9485316] synonym: "HSPas binding" EXACT [PMID:9485316] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0070363 name: mitochondrial light strand promoter sense binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "LSP coding strand binding" EXACT [PMID:9485316] synonym: "LSPs binding" EXACT [PMID:9485316] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0070364 name: mitochondrial heavy strand promoter sense binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "HSP coding strand binding" EXACT [PMID:9485316] synonym: "HSPs binding" EXACT [PMID:9485316] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0070365 name: hepatocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884] synonym: "liver cell differentiation" EXACT [GOC:mah] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001889 ! liver development [Term] id: GO:0070366 name: regulation of hepatocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "regulation of liver cell differentiation" EXACT [GOC:sl] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0070365 ! hepatocyte differentiation [Term] id: GO:0070367 name: negative regulation of hepatocyte differentiation namespace: biological_process def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah] synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070366 ! regulation of hepatocyte differentiation relationship: negatively_regulates GO:0070365 ! hepatocyte differentiation [Term] id: GO:0070368 name: positive regulation of hepatocyte differentiation namespace: biological_process def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah] synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl] synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah] synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070366 ! regulation of hepatocyte differentiation relationship: positively_regulates GO:0070365 ! hepatocyte differentiation [Term] id: GO:0070369 name: beta-catenin-TCF7L2 complex namespace: cellular_component def: "A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, PMID:9065401, PMID:9065402] subset: gosubset_prok synonym: "beta-catenin-TCF4 complex" EXACT [PMID:9065401, PMID:9065402] is_a: GO:0071664 ! catenin-TCF7L2 complex [Term] id: GO:0070370 name: cellular heat acclimation namespace: biological_process def: "Any process that increases heat tolerance of a cell in response to high temperatures." [GOC:jp] synonym: "cellular thermotolerance" EXACT [GOC:jp] is_a: GO:0010286 ! heat acclimation is_a: GO:0034605 ! cellular response to heat [Term] id: GO:0070371 name: ERK1 and ERK2 cascade namespace: biological_process def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases." [GOC:add, ISBN:0121245462, ISBN:0896039986] comment: Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases. synonym: "ERK cascade" BROAD [GOC:add] synonym: "ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] synonym: "ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] synonym: "ERK1 cascade" NARROW [GOC:add] synonym: "ERK1/2 cascade" EXACT [GOC:add] synonym: "ERK2 cascade" NARROW [GOC:add] synonym: "MAPK1 cascade" NARROW [GOC:add] synonym: "MAPK3 cascade" NARROW [GOC:add] xref: Reactome:112411 "ERK2 activation" xref: Reactome:1253161 "ERK2 activation" xref: Reactome:1280095 "ERK2 activation" xref: Reactome:1298944 "ERK2 activation" xref: Reactome:1326666 "ERK2 activation" xref: Reactome:1352778 "ERK2 activation" xref: Reactome:1372967 "ERK2 activation" xref: Reactome:1392983 "ERK2 activation" xref: Reactome:1417463 "ERK2 activation" xref: Reactome:1450578 "ERK2 activation" xref: Reactome:1471085 "ERK2 activation" xref: Reactome:1483101 "ERK2 activation" xref: Reactome:1526824 "ERK2 activation" xref: Reactome:1532550 "ERK2 activation" xref: Reactome:451478 "ERK activation" xref: Reactome:451533 "ERK2 activation" is_a: GO:0000165 ! MAPKKK cascade [Term] id: GO:0070372 name: regulation of ERK1 and ERK2 cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] synonym: "regulation of ERK cascade" BROAD [GOC:add] synonym: "regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] synonym: "regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] synonym: "regulation of ERK1 cascade" NARROW [GOC:add] synonym: "regulation of ERK1/2 cascade" EXACT [GOC:add] synonym: "regulation of ERK2 cascade" NARROW [GOC:add] synonym: "regulation of MAPK1 cascade" NARROW [GOC:add] synonym: "regulation of MAPK3 cascade" NARROW [GOC:add] is_a: GO:0043408 ! regulation of MAPKKK cascade relationship: regulates GO:0070371 ! ERK1 and ERK2 cascade [Term] id: GO:0070373 name: negative regulation of ERK1 and ERK2 cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] synonym: "down regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "down-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "downregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "inhibition of ERK1 and ERK2 cascade" NARROW [GOC:mah] synonym: "negative regulation of ERK cascade" BROAD [GOC:add] synonym: "negative regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of ERK1 cascade" NARROW [GOC:add] synonym: "negative regulation of ERK1/2 cascade" EXACT [GOC:add] synonym: "negative regulation of ERK2 cascade" NARROW [GOC:add] synonym: "negative regulation of MAPK1 cascade" NARROW [GOC:add] synonym: "negative regulation of MAPK3 cascade" NARROW [GOC:add] is_a: GO:0043409 ! negative regulation of MAPKKK cascade is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade relationship: negatively_regulates GO:0070371 ! ERK1 and ERK2 cascade [Term] id: GO:0070374 name: positive regulation of ERK1 and ERK2 cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah] synonym: "activation of ERK1 and ERK2 cascade" NARROW [GOC:mah] synonym: "positive regulation of ERK cascade" BROAD [GOC:add] synonym: "positive regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of ERK1 cascade" NARROW [GOC:add] synonym: "positive regulation of ERK1/2 cascade" EXACT [GOC:add] synonym: "positive regulation of ERK2 cascade" NARROW [GOC:add] synonym: "positive regulation of MAPK1 cascade" NARROW [GOC:add] synonym: "positive regulation of MAPK3 cascade" NARROW [GOC:add] synonym: "stimulation of ERK1 and ERK2 cascade" NARROW [GOC:mah] synonym: "up regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "up-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "upregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] is_a: GO:0043410 ! positive regulation of MAPKKK cascade is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade relationship: positively_regulates GO:0070371 ! ERK1 and ERK2 cascade [Term] id: GO:0070375 name: BMK cascade namespace: biological_process def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase." [GOC:add, ISBN:0896039986, PMID:16376520, PMID:16880823] synonym: "BMK signaling pathway" EXACT [GOC:mah] synonym: "BMK signalling pathway" EXACT [GOC:mah] synonym: "BMK1 cascade" EXACT [GOC:add] synonym: "ERK5 cascade" EXACT [GOC:add] synonym: "ERK5 signaling pathway" EXACT [PMID:16376520] synonym: "MAPK7 cascade" EXACT [GOC:add] is_a: GO:0000165 ! MAPKKK cascade [Term] id: GO:0070376 name: regulation of BMK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the BMK cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] synonym: "regulation of BMK signaling pathway" EXACT [GOC:mah] synonym: "regulation of BMK signalling pathway" EXACT [GOC:mah] synonym: "regulation of BMK1 cascade" EXACT [GOC:add] synonym: "regulation of ERK5 cascade" EXACT [GOC:add] synonym: "regulation of ERK5 signaling pathway" EXACT [PMID:16376520] synonym: "regulation of MAPK7 cascade" EXACT [GOC:add] is_a: GO:0043408 ! regulation of MAPKKK cascade relationship: regulates GO:0070375 ! BMK cascade [Term] id: GO:0070377 name: negative regulation of BMK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the BMK cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] synonym: "down regulation of BMK cascade" EXACT [GOC:mah] synonym: "down-regulation of BMK cascade" EXACT [GOC:mah] synonym: "downregulation of BMK cascade" EXACT [GOC:mah] synonym: "inhibition of BMK cascade" NARROW [GOC:mah] synonym: "negative regulation of BMK signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of BMK signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of BMK1 cascade" EXACT [GOC:add] synonym: "negative regulation of ERK5 cascade" EXACT [GOC:add] synonym: "negative regulation of ERK5 signaling pathway" EXACT [PMID:16376520] synonym: "negative regulation of MAPK7 cascade" EXACT [GOC:add] is_a: GO:0043409 ! negative regulation of MAPKKK cascade is_a: GO:0070376 ! regulation of BMK cascade relationship: negatively_regulates GO:0070375 ! BMK cascade [Term] id: GO:0070378 name: positive regulation of BMK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the BMK cascade." [GOC:mah] synonym: "activation of BMK cascade" NARROW [GOC:mah] synonym: "positive regulation of BMK signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of BMK signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of BMK1 cascade" EXACT [GOC:add] synonym: "positive regulation of ERK5 cascade" EXACT [GOC:add] synonym: "positive regulation of ERK5 signaling pathway" EXACT [PMID:16376520] synonym: "positive regulation of MAPK7 cascade" EXACT [GOC:add] synonym: "stimulation of BMK cascade" NARROW [GOC:mah] synonym: "up regulation of BMK cascade" EXACT [GOC:mah] synonym: "up-regulation of BMK cascade" EXACT [GOC:mah] synonym: "upregulation of BMK cascade" EXACT [GOC:mah] is_a: GO:0043410 ! positive regulation of MAPKKK cascade is_a: GO:0070376 ! regulation of BMK cascade relationship: positively_regulates GO:0070375 ! BMK cascade [Term] id: GO:0070379 name: high mobility group box 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with high mobility group box 1 (HMBGB1)." [GOC:add, PMID:18431461] synonym: "HMGB1 binding" EXACT [GOC:add] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0070380 name: high mobility group box 1 receptor activity namespace: molecular_function def: "Combining with high mobility group box 1 (HMBGB1) to initiate a change in cell activity." [GOC:add, PMID:18431461] synonym: "HMGB1 receptor activity" EXACT [GOC:add] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0070379 ! high mobility group box 1 binding [Term] id: GO:0070381 name: endosome to plasma membrane transport vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah, PMID:10679016, PMID:12110576] synonym: "endosome-plasma membrane transport vesicle" EXACT [GOC:mah] is_a: GO:0070382 ! exocytic vesicle [Term] id: GO:0070382 name: exocytic vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] synonym: "exocytotic vesicle" EXACT [GOC:kad] is_a: GO:0030133 ! transport vesicle [Term] id: GO:0070383 name: DNA cytosine deamination namespace: biological_process def: "The removal of an amino group from a cytosine residue in DNA, forming a uracil residue." [GOC:mah] is_a: GO:0045006 ! DNA deamination [Term] id: GO:0070384 name: Harderian gland development namespace: biological_process def: "The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species." [GOC:hjd, PMID:16856596, PMID:7559104] comment: Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages. is_a: GO:0048732 ! gland development [Term] id: GO:0070385 name: egasyn-beta-glucuronidase complex namespace: cellular_component def: "A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum." [PMID:7744842] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0070386 name: procollagen-proline 4-dioxygenase complex, alpha(I) type namespace: cellular_component def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline)." [PMID:14500733, PMID:7753822] synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type" EXACT [PMID:7753822] synonym: "prolyl 4-hydroxylase complex (alpha(I)-type)" BROAD [CORUM:472] is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex [Term] id: GO:0070387 name: procollagen-proline 4-dioxygenase complex, alpha(II) type namespace: cellular_component def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations." [PMID:14500733, PMID:7753822] synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type" EXACT [PMID:7753822] synonym: "prolyl 4-hydroxylase complex (alpha(II)-type)" BROAD [CORUM:473] is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex [Term] id: GO:0070388 name: procollagen-proline 4-dioxygenase complex, alpha(III) type namespace: cellular_component def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform." [PMID:14500733] synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type" EXACT [PMID:14500733] synonym: "prolyl 4-hydroxylase complex (alpha(III)-type)" BROAD [CORUM:474] is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex [Term] id: GO:0070389 name: chaperone cofactor-dependent protein refolding namespace: biological_process def: "The process of assisting in the restoration of the biological activity of an unfolded or misfolded protein, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:mah, GOC:rb] subset: gosubset_prok synonym: "chaperone co-factor-dependent protein refolding" EXACT [] is_a: GO:0042026 ! protein refolding is_a: GO:0061077 ! chaperone-mediated protein folding [Term] id: GO:0070390 name: transcription export complex 2 namespace: cellular_component def: "A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152] synonym: "Sac3-Thp1-Sus1-Cdc31 complex" EXACT [PMID:17786152] synonym: "TREX-2 complex" EXACT [GOC:dgf] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070391 name: response to lipoteichoic acid namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] synonym: "response to LTA" EXACT [GOC:add] is_a: GO:0002237 ! response to molecule of bacterial origin [Term] id: GO:0070392 name: detection of lipoteichoic acid namespace: biological_process def: "The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] synonym: "detection of LTA" EXACT [GOC:add] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0070391 ! response to lipoteichoic acid [Term] id: GO:0070393 name: teichoic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues." [GOC:add, PMID:14665680] synonym: "teichoic acid breakdown" EXACT [GOC:add] synonym: "teichoic acid catabolism" EXACT [GOC:add] synonym: "teichoic acid degradation" EXACT [GOC:add] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0046374 ! teichoic acid metabolic process [Term] id: GO:0070394 name: lipoteichoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] synonym: "lipoteichoic acid metabolism" EXACT [GOC:add] synonym: "LTA metabolic process" EXACT [GOC:add] is_a: GO:0046374 ! teichoic acid metabolic process [Term] id: GO:0070395 name: lipoteichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] synonym: "lipoteichoic acid anabolism" EXACT [GOC:add] synonym: "lipoteichoic acid biosynthesis" EXACT [GOC:add] synonym: "lipoteichoic acid formation" EXACT [GOC:add] synonym: "lipoteichoic acid synthesis" EXACT [GOC:add] synonym: "LTA biosynthetic process" BROAD [GOC:add] is_a: GO:0019350 ! teichoic acid biosynthetic process is_a: GO:0070394 ! lipoteichoic acid metabolic process [Term] id: GO:0070396 name: lipoteichoic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680] synonym: "lipoteichoic acid breakdown" EXACT [GOC:add] synonym: "lipoteichoic acid catabolism" EXACT [GOC:add] synonym: "lipoteichoic acid degradation" EXACT [GOC:add] is_a: GO:0070393 ! teichoic acid catabolic process is_a: GO:0070394 ! lipoteichoic acid metabolic process [Term] id: GO:0070397 name: wall teichoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688] synonym: "wall teichoic acid metabolism" EXACT [GOC:add] synonym: "WTA metabolic process" EXACT [GOC:add] is_a: GO:0046374 ! teichoic acid metabolic process [Term] id: GO:0070398 name: wall teichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688] synonym: "wall teichoic acid anabolism" EXACT [GOC:add] synonym: "wall teichoic acid biosynthesis" EXACT [GOC:add] synonym: "wall teichoic acid formation" EXACT [GOC:add] synonym: "wall teichoic acid synthesis" EXACT [GOC:add] synonym: "WTA biosynthetic process" EXACT [GOC:add] is_a: GO:0019350 ! teichoic acid biosynthetic process is_a: GO:0070397 ! wall teichoic acid metabolic process [Term] id: GO:0070399 name: wall teichoic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680] synonym: "wall teichoic acid breakdown" EXACT [GOC:add] synonym: "wall teichoic acid catabolism" EXACT [GOC:add] synonym: "wall teichoic acid degradation" EXACT [GOC:add] is_a: GO:0070397 ! wall teichoic acid metabolic process [Term] id: GO:0070400 name: teichoic acid D-alanylation namespace: biological_process def: "The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid." [GOC:add, PMID:14665680, PMID:16020688] synonym: "teichoic acid alanylation" EXACT [GOC:add] is_a: GO:0019350 ! teichoic acid biosynthetic process [Term] id: GO:0070401 name: NADP+ binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] synonym: "NADP (oxidized) binding" EXACT [GOC:mah] synonym: "NADP binding" RELATED [GOC:mah] synonym: "oxidized NADP binding" EXACT [GOC:mah] synonym: "oxidized nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah] is_a: GO:0050661 ! NADP binding [Term] id: GO:0070402 name: NADPH binding namespace: molecular_function def: "Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] synonym: "NADP (reduced) binding" EXACT [GOC:mah] synonym: "reduced NADP binding" EXACT [GOC:mah] synonym: "reduced nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah] is_a: GO:0050661 ! NADP binding [Term] id: GO:0070403 name: NAD+ binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] synonym: "NAD (oxidized) binding" EXACT [GOC:mah] synonym: "NAD binding" RELATED [GOC:mah] synonym: "oxidized NAD binding" EXACT [GOC:mah] synonym: "oxidized nicotinamide adenine dinucleotide binding" EXACT [GOC:mah] is_a: GO:0051287 ! NAD binding [Term] id: GO:0070404 name: NADH binding namespace: molecular_function def: "Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] synonym: "NAD (reduced) binding" EXACT [GOC:mah] synonym: "reduced NAD binding" EXACT [GOC:mah] synonym: "reduced nicotinamide adenine dinucleotide binding" EXACT [GOC:mah] is_a: GO:0051287 ! NAD binding [Term] id: GO:0070405 name: ammonium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with ammonium ions (NH4+)." [CHEBI:28938, GOC:ecd] is_a: GO:0043169 ! cation binding [Term] id: GO:0070406 name: glutamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with glutamine, 2,5-diamino-5-oxopentanoic acid." [CHEBI:28300, GOC:ecd] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0070407 name: oxidation-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein." [GOC:mah] synonym: "oxidation-dependent protein breakdown" EXACT [GOC:mah] synonym: "oxidation-dependent protein catabolism" EXACT [GOC:mah] synonym: "oxidation-dependent protein degradation" EXACT [GOC:mah] synonym: "oxidation-dependent proteolysis" EXACT [GOC:mah] synonym: "oxidized protein catabolic process" EXACT [GOC:mah] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0070408 name: carbamoyl phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph] synonym: "carbamoyl phosphate metabolism" EXACT [GOC:mah] xref: UM-BBD_pathwayID:bzn is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0070409 name: carbamoyl phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph] subset: gosubset_prok synonym: "carbamoyl phosphate anabolism" EXACT [] synonym: "carbamoyl phosphate biosynthesis" EXACT [] synonym: "carbamoyl phosphate formation" EXACT [] synonym: "carbamoyl phosphate synthesis" EXACT [] synonym: "carbamyl phosphate biosynthetic process" EXACT [GOC:rph] is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0070408 ! carbamoyl phosphate metabolic process [Term] id: GO:0070410 name: co-SMAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] is_a: GO:0046332 ! SMAD binding [Term] id: GO:0070411 name: I-SMAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] is_a: GO:0046332 ! SMAD binding [Term] id: GO:0070412 name: R-SMAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] is_a: GO:0046332 ! SMAD binding [Term] id: GO:0070413 name: trehalose metabolism in response to stress namespace: biological_process def: "The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress." [GOC:jp, GOC:mah, PMID:9797333] synonym: "trehalose metabolic process involved in response to stress" EXACT systematic_synonym [GOC:mah] is_a: GO:0005991 ! trehalose metabolic process is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0070414 name: trehalose metabolism in response to heat stress namespace: biological_process def: "The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333] synonym: "trehalose metabolic process involved in response to heat stress" EXACT systematic_synonym [GOC:mah] is_a: GO:0034605 ! cellular response to heat is_a: GO:0070413 ! trehalose metabolism in response to stress [Term] id: GO:0070415 name: trehalose metabolism in response to cold stress namespace: biological_process def: "The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333] synonym: "trehalose metabolic process involved in response to cold stress" EXACT systematic_synonym [GOC:mah] is_a: GO:0070413 ! trehalose metabolism in response to stress is_a: GO:0070417 ! cellular response to cold [Term] id: GO:0070416 name: trehalose metabolism in response to water deprivation namespace: biological_process def: "The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water." [GOC:jp, GOC:mah, PMID:9797333] synonym: "trehalose metabolic process involved in response to water deprivation" EXACT systematic_synonym [GOC:mah] is_a: GO:0042631 ! cellular response to water deprivation is_a: GO:0070413 ! trehalose metabolism in response to stress [Term] id: GO:0070417 name: cellular response to cold namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp] synonym: "cellular response to cold stress" EXACT [GOC:jp] is_a: GO:0009409 ! response to cold is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0070418 name: DNA-dependent protein kinase complex namespace: cellular_component def: "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392] synonym: "DNA-dependent protein kinase, DNA-end-binding complex" NARROW [] synonym: "DNA-PK complex" EXACT [] synonym: "DNA-PK-Ku antigen complex" EXACT [CORUM:355] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070419 name: nonhomologous end joining complex namespace: cellular_component def: "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628] synonym: "NHEJ complex" EXACT [GOC:mah] synonym: "non-homologous end joining complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0070420 name: Ku-DNA ligase complex namespace: cellular_component def: "A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria." [GOC:mah, PMID:17938628] is_a: GO:0070419 ! nonhomologous end joining complex [Term] id: GO:0070421 name: DNA ligase III-XRCC1 complex namespace: cellular_component def: "A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair." [PMID:15141024, PMID:7760816] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070422 name: G-protein beta/gamma-Raf-1 complex namespace: cellular_component def: "A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7782277] comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. synonym: "G protein complex (GNG2, GNB2L1, RAF1)" RELATED [CORUM:1539] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070423 name: nucleotide-binding oligomerization domain containing signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein." [GOC:add, PMID:17944960, PMID:18585455] synonym: "NOD signaling pathway" EXACT [GOC:add] synonym: "nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway is_a: GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [Term] id: GO:0070424 name: regulation of nucleotide-binding oligomerization domain containing signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] synonym: "regulation of NOD signaling pathway" EXACT [GOC:add] synonym: "regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070425 name: negative regulation of nucleotide-binding oligomerization domain containing signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] synonym: "negative regulation of NOD signaling pathway" EXACT [GOC:add] synonym: "negative regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway relationship: negatively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070426 name: positive regulation of nucleotide-binding oligomerization domain containing signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] synonym: "positive regulation of NOD signaling pathway" EXACT [GOC:add] synonym: "positive regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway relationship: positively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070427 name: nucleotide-binding oligomerization domain containing 1 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 1 (NOD1)." [GOC:add, PMID:17944960, PMID:18585455] synonym: "NOD1 signaling pathway" EXACT [GOC:add] synonym: "nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070428 name: regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] synonym: "regulation of NOD1 signaling pathway" EXACT [GOC:add] synonym: "regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway relationship: regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway [Term] id: GO:0070429 name: negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] synonym: "negative regulation of NOD1 signaling pathway" EXACT [GOC:add] synonym: "negative regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway relationship: negatively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway [Term] id: GO:0070430 name: positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] synonym: "positive regulation of NOD1 signaling pathway" EXACT [GOC:add] synonym: "positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway relationship: positively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway [Term] id: GO:0070431 name: nucleotide-binding oligomerization domain containing 2 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2)." [GOC:add, PMID:17944960, PMID:18585455] synonym: "NOD2 signaling pathway" EXACT [GOC:add] synonym: "nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070432 name: regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add] synonym: "regulation of NOD2 signaling pathway" EXACT [GOC:add] synonym: "regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway relationship: regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway [Term] id: GO:0070433 name: negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add] synonym: "negative regulation of NOD2 signaling pathway" EXACT [GOC:add] synonym: "negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway relationship: negatively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway [Term] id: GO:0070434 name: positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add] synonym: "positive regulation of NOD2 signaling pathway" EXACT [GOC:add] synonym: "positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway relationship: positively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway [Term] id: GO:0070435 name: Shc-EGFR complex namespace: cellular_component def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267] synonym: "Shc-Egfr complex, EGF stimulated" NARROW [CORUM:2887] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070436 name: Grb2-EGFR complex namespace: cellular_component def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267] synonym: "Grb2-Egfr complex, EGF stimulated" NARROW [CORUM:2889] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070437 name: Grb2-Shc complex namespace: cellular_component def: "A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway." [GOC:mah, PMID:7798267] synonym: "Grb2-Shc complex, EGF stimulated" NARROW [CORUM:2888] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070438 name: mTOR-FKBP12-rapamycin complex namespace: cellular_component def: "A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase, the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A) and rapamycin (sirolimus)." [GOC:sl, PMID:20005306, PMID:7822316] synonym: "Fkbp1a-Frap1 complex" NARROW [CORUM:2987] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0070439 name: Mad-Max-mSin3A complex namespace: cellular_component def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p." [PMID:7889570] is_a: GO:0017053 ! transcriptional repressor complex [Term] id: GO:0070440 name: Mad-Max-mSin3B complex namespace: cellular_component def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p." [PMID:7889570] is_a: GO:0017053 ! transcriptional repressor complex [Term] id: GO:0070441 name: G-protein beta/gamma-Btk complex namespace: cellular_component def: "A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7972043] comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. synonym: "G protein complex (BTK, GNG1, GNG2)" RELATED [CORUM:1615] synonym: "G protein complex (Btk, Gng2, Gnb1)" RELATED [CORUM:3195] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070442 name: alphaIIb-beta3 integrin complex namespace: cellular_component def: "An integrin complex that comprises one alphaIIb subunit and one beta3 subunit." [PMID:12297042] synonym: "ITGA2B-ITGB3 complex" NARROW [CORUM:2381] is_a: GO:0008305 ! integrin complex [Term] id: GO:0070443 name: Mad-Max complex namespace: cellular_component def: "A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max." [PMID:8224841] is_a: GO:0017053 ! transcriptional repressor complex [Term] id: GO:0070444 name: oligodendrocyte progenitor proliferation namespace: biological_process def: "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system." [GOC:mah, GOC:sl, PMID:15504915] synonym: "oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0070445 name: regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:2000177 ! regulation of neural precursor cell proliferation relationship: regulates GO:0070444 ! oligodendrocyte progenitor proliferation [Term] id: GO:0070446 name: negative regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "negative regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation relationship: negatively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation [Term] id: GO:0070447 name: positive regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "positive regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation relationship: positively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation [Term] id: GO:0070448 name: laricitrin 5'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin." [MetaCyc:RXN-8452] comment: Note that this term represents one of two reactions that are grouped together in EC 2.1.1.149. synonym: "CrCOMT2" RELATED [EC:2.1.1.149] synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [EC:2.1.1.149] synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [EC:2.1.1.149] xref: EC:2.1.1.149 xref: MetaCyc:RXN-8452 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0070449 name: elongin complex namespace: cellular_component def: "A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits." [PMID:12676794] comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. synonym: "elongin (SIII) complex" EXACT [CORUM:56] synonym: "transcription elongation factor SIII complex" EXACT [PMID:8244996] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0070450 name: interleukin4-interleukin-4 receptor complex namespace: cellular_component def: "A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule." [GOC:mah, PMID:10358772] subset: goslim_pir synonym: "IL4-IL4 receptor complex" EXACT [GOC:mah] synonym: "IL4-IL4R-IL2RG complex" NARROW [CORUM:1515] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070451 name: cell hair namespace: cellular_component def: "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084] subset: goslim_pir synonym: "imaginal disc-derived wing hair" NARROW [GOC:mah] synonym: "non-sensory hair" EXACT [GOC:bf] xref: Wikipedia:Membrane_nanotube is_a: GO:0042995 ! cell projection [Term] id: GO:0070452 name: positive regulation of ergosterol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah] synonym: "activation of ergosterol biosynthetic process" NARROW [] synonym: "positive regulation of ergosterol anabolism" EXACT [] synonym: "positive regulation of ergosterol biosynthesis" EXACT [] synonym: "positive regulation of ergosterol formation" EXACT [] synonym: "positive regulation of ergosterol synthesis" EXACT [] synonym: "stimulation of ergosterol biosynthetic process" NARROW [] synonym: "up regulation of ergosterol biosynthetic process" EXACT [] synonym: "up-regulation of ergosterol biosynthetic process" EXACT [] synonym: "upregulation of ergosterol biosynthetic process" EXACT [] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032443 ! regulation of ergosterol biosynthetic process relationship: positively_regulates GO:0006696 ! ergosterol biosynthetic process [Term] id: GO:0070453 name: regulation of heme biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah] subset: gosubset_prok synonym: "regulation of haem biosynthesis" EXACT [GOC:mah] synonym: "regulation of haem biosynthetic process" EXACT [GOC:mah] synonym: "regulation of heme anabolism" EXACT [GOC:mah] synonym: "regulation of heme biosynthesis" EXACT [GOC:mah] synonym: "regulation of heme formation" EXACT [GOC:mah] synonym: "regulation of heme synthesis" EXACT [GOC:mah] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process relationship: regulates GO:0006783 ! heme biosynthetic process [Term] id: GO:0070454 name: negative regulation of heme biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah] synonym: "down regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of heme biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of haem biosynthetic process" EXACT [GOC:mah] synonym: "negative regulation of heme anabolism" EXACT [GOC:mah] synonym: "negative regulation of heme biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of heme formation" EXACT [GOC:mah] synonym: "negative regulation of heme synthesis" EXACT [GOC:mah] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0070453 ! regulation of heme biosynthetic process relationship: negatively_regulates GO:0006783 ! heme biosynthetic process [Term] id: GO:0070455 name: positive regulation of heme biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah] synonym: "activation of heme biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of haem biosynthetic process" EXACT [GOC:mah] synonym: "positive regulation of heme anabolism" EXACT [GOC:mah] synonym: "positive regulation of heme biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of heme formation" EXACT [GOC:mah] synonym: "positive regulation of heme synthesis" EXACT [GOC:mah] synonym: "stimulation of heme biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of heme biosynthetic process" EXACT [GOC:mah] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0070453 ! regulation of heme biosynthetic process relationship: positively_regulates GO:0006783 ! heme biosynthetic process [Term] id: GO:0070456 name: galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate." [GOC:mah] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0070457 name: D-galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate." [GOC:mah, PMID:9462881] is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity [Term] id: GO:0070458 name: cellular detoxification of nitrogen compound namespace: biological_process def: "Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:mah] synonym: "cellular detoxification of nitrogenous compound" EXACT [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0070459 name: prolactin secretion namespace: biological_process def: "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070460 name: thyroid-stimulating hormone secretion namespace: biological_process def: "The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "thyroid stimulating hormone secretion" EXACT [GOC:mah] synonym: "TSH secretion" EXACT [] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070461 name: SAGA-type complex namespace: cellular_component def: "A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [GOC:mah, PMID:10637607, PMID:17337012] synonym: "SAGA family complex" EXACT [PMID:17337012] is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0070462 name: plus-end specific microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148] is_a: GO:0007019 ! microtubule depolymerization [Term] id: GO:0070463 name: tubulin-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate." [GOC:mah, PMID:16906148] synonym: "tubulin-activated ATPase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0070464 name: alphav-beta3 integrin-collagen alpha3(VI) complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen." [PMID:8387021] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070465 name: alpha1-beta1 integrin-alpha3(VI) complex namespace: cellular_component def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021] synonym: "ITGA1-ITGB1-COL6A3 complex" NARROW [CORUM:2434] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070466 name: alpha2-beta1 integrin-alpha3(VI) complex namespace: cellular_component def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021] synonym: "ITGA2-ITGB1-COL6A3 complex" NARROW [CORUM:2431] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070467 name: RC-1 DNA recombination complex namespace: cellular_component def: "A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA." [PMID:8392064, PMID:8670910] synonym: "DNA recombination complex RC-1" EXACT [GOC:mah] synonym: "RC-1 complex (recombination complex 1)" EXACT [CORUM:364] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070468 name: dentine secretion namespace: biological_process def: "The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentine." [GOC:mah, http://herkules.oulu.fi/isbn9514270355/html/i259726.html, PMID:12856968] synonym: "dentin secretion" EXACT [GOC:mah] synonym: "predentin secretion" EXACT [http://herkules.oulu.fi/isbn9514270355/html/i259726.html] is_a: GO:0070278 ! extracellular matrix constituent secretion relationship: part_of GO:0042475 ! odontogenesis of dentine-containing tooth [Term] id: GO:0070469 name: respiratory chain namespace: cellular_component def: "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] synonym: "membrane electron transport chain" EXACT [GOC:mah] is_a: GO:0044425 ! membrane part [Term] id: GO:0070470 name: plasma membrane respiratory chain namespace: cellular_component def: "A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:mah, ISBN:0198547684] synonym: "plasma membrane electron transport chain" EXACT [GOC:mah] is_a: GO:0044459 ! plasma membrane part is_a: GO:0070469 ! respiratory chain [Term] id: GO:0070471 name: uterine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth." [GOC:sl] synonym: "myometrial contraction" EXACT [GOC:sl] synonym: "myometrial smooth muscle contraction" EXACT [GOC:sl] synonym: "myometrium contraction" EXACT [GOC:sl] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0070472 name: regulation of uterine smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators] synonym: "regulation of myometrial contraction" EXACT [GOC:sl] synonym: "regulation of myometrial smooth muscle contraction" EXACT [GOC:sl] synonym: "regulation of myometrium contraction" EXACT [GOC:sl] is_a: GO:0006940 ! regulation of smooth muscle contraction relationship: regulates GO:0070471 ! uterine smooth muscle contraction [Term] id: GO:0070473 name: negative regulation of uterine smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators] synonym: "down regulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "down-regulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "downregulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "inhibition of uterine smooth muscle contraction" NARROW [GOC:mah] synonym: "negative regulation of myometrial contraction" EXACT [GOC:sl] synonym: "negative regulation of myometrial smooth muscle contraction" EXACT [GOC:sl] synonym: "negative regulation of myometrium contraction" EXACT [GOC:sl] synonym: "uterine smooth muscle relaxation" RELATED [GOC:mah] is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:0070472 ! regulation of uterine smooth muscle contraction relationship: negatively_regulates GO:0070471 ! uterine smooth muscle contraction [Term] id: GO:0070474 name: positive regulation of uterine smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators] synonym: "activation of uterine smooth muscle contraction" NARROW [GOC:mah] synonym: "positive regulation of myometrial contraction" EXACT [GOC:sl] synonym: "positive regulation of myometrial smooth muscle contraction" EXACT [GOC:sl] synonym: "positive regulation of myometrium contraction" EXACT [GOC:sl] synonym: "stimulation of uterine smooth muscle contraction" NARROW [GOC:mah] synonym: "up regulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "up-regulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "upregulation of uterine smooth muscle contraction" EXACT [GOC:mah] is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:0070472 ! regulation of uterine smooth muscle contraction relationship: positively_regulates GO:0070471 ! uterine smooth muscle contraction [Term] id: GO:0070475 name: rRNA base methylation namespace: biological_process def: "The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah] is_a: GO:0031167 ! rRNA methylation [Term] id: GO:0070476 name: rRNA (guanine-N7)-methylation namespace: biological_process def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [GOC:mah] is_a: GO:0070475 ! rRNA base methylation [Term] id: GO:0070477 name: endospore core namespace: cellular_component def: "An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive." [GOC:mah, PMID:15035041, PMID:18035610] is_a: GO:0044424 ! intracellular part [Term] id: GO:0070478 name: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [PMID:12769863] synonym: "3'-5' NMD" EXACT [GOC:jp] synonym: "3'-5' nonsense-mediated decay" EXACT [GOC:jp] synonym: "3'-5' nonsense-mediated mRNA decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay is_a: GO:0034427 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' is_a: GO:0043928 ! exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [Term] id: GO:0070479 name: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [PMID:18554525] synonym: "5'-3' NMD" EXACT [GOC:jp] synonym: "5'-3' nonsense-mediated decay" EXACT [GOC:jp] synonym: "5'-3' nonsense-mediated mRNA decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA degradation, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay is_a: GO:0034428 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' is_a: GO:0070480 ! exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay [Term] id: GO:0070480 name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:jp] synonym: "exonucleolytic nuclear-transcribed mRNA breakdown involved in deadenylation-independent decay" EXACT [GOC:mah] synonym: "exonucleolytic nuclear-transcribed mRNA catabolism involved in deadenylation-independent decay" EXACT [GOC:mah] synonym: "exonucleolytic nuclear-transcribed mRNA degradation involved in deadenylation-independent decay" EXACT [GOC:mah] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic is_a: GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [Term] id: GO:0070481 name: nuclear-transcribed mRNA catabolic process, non-stop decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon." [PMID:11910110] synonym: "non-stop decay" EXACT [GOC:jp] synonym: "non-stop mRNA decay" EXACT [GOC:jp] synonym: "nonstop mRNA decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA breakdown, non-stop decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA catabolism, non-stop decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA degradation, non-stop decay" EXACT [GOC:mah] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0070482 name: response to oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0070483 name: detection of hypoxia namespace: biological_process def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah] synonym: "detection of reduced oxygen levels" EXACT [GOC:vk] is_a: GO:0001666 ! response to hypoxia is_a: GO:0003032 ! detection of oxygen [Term] id: GO:0070484 name: dehydro-D-arabinono-1,4-lactone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [CHEBI:17803, GOC:cjk, GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone metabolism" EXACT [GOC:mah] is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0070485 name: dehydro-D-arabinono-1,4-lactone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [CHEBI:17803, GOC:cjk, GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone anabolism" EXACT [GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone biosynthesis" EXACT [GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone formation" EXACT [GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0070484 ! dehydro-D-arabinono-1,4-lactone metabolic process [Term] id: GO:0070486 name: leukocyte aggregation namespace: biological_process def: "The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules." [GOC:sl, PMID:12972508] synonym: "immune cell aggregation" EXACT [CL:0000738] synonym: "leucocyte aggregation" EXACT [CL:0000738, GOC:sl] synonym: "white blood cell aggregation" EXACT [CL:0000738, GOC:sl] synonym: "white corpuscle aggregation" EXACT [GOC:sl] is_a: GO:0007159 ! leukocyte cell-cell adhesion is_a: GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0070487 name: monocyte aggregation namespace: biological_process def: "The adhesion of one monocyte to one or more other monocytes via adhesion molecules." [GOC:sl, PMID:12972508] synonym: "mononuclear phagocyte aggregation" EXACT [GOC:sl] is_a: GO:0070486 ! leukocyte aggregation [Term] id: GO:0070488 name: neutrophil aggregation namespace: biological_process def: "The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules." [GOC:sl, PMID:12972508] synonym: "neutrocyte aggregation" EXACT [CL:0000775, GOC:mah] synonym: "neutrophil leucocyte aggregation" EXACT [CL:0000775, GOC:mah] synonym: "neutrophil leukocyte aggregation" EXACT [CL:0000775, GOC:mah] synonym: "neutrophilic leucocyte aggregation" EXACT [CL:0000775, GOC:mah] synonym: "neutrophilic leukocyte aggregation" EXACT [CL:0000775, GOC:mah] is_a: GO:0070486 ! leukocyte aggregation [Term] id: GO:0070489 name: T cell aggregation namespace: biological_process def: "The adhesion of one T cell to one or more other T cells via adhesion molecules." [GOC:sl, PMID:12972508] synonym: "T lymphocyte aggregation" EXACT [CL:0000084, GOC:sl] synonym: "T-cell aggregation" EXACT [CL:0000084, GOC:mah] synonym: "T-lymphocyte aggregation" EXACT [CL:0000084, GOC:mah] is_a: GO:0071593 ! lymphocyte aggregation [Term] id: GO:0070490 name: protein pupylation namespace: biological_process def: "The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of Pup and the epsilon-amino group of a lysine residue of the target protein." [PMID:18980670] synonym: "Pup-protein conjugation" EXACT [GOC:mah] synonym: "pupylation" EXACT [GOC:mah] is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0070491 name: repressing transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0070492 name: oligosaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah] subset: gosubset_prok is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0070493 name: thrombin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah, PMID:1672265] synonym: "thrombin receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0070494 name: regulation of thrombin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a thrombin receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "regulation of thrombin receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway relationship: regulates GO:0070493 ! thrombin receptor signaling pathway [Term] id: GO:0070495 name: negative regulation of thrombin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "negative regulation of thrombin receptor signalling pathway" RELATED [GOC:mah] is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0070494 ! regulation of thrombin receptor signaling pathway relationship: negatively_regulates GO:0070493 ! thrombin receptor signaling pathway [Term] id: GO:0070496 name: positive regulation of thrombin receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "positive regulation of thrombin receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0070494 ! regulation of thrombin receptor signaling pathway relationship: positively_regulates GO:0070493 ! thrombin receptor signaling pathway [Term] id: GO:0070497 name: 6-carboxy-5,6,7,8-tetrahydropterin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + PPPi." [GOC:imk, PMID:19231875] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0070498 name: interleukin-1-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of interleukin-1 binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "IL-1 alpha-mediated signaling pathway" NARROW [GOC:add] synonym: "IL-1 beta-mediated signaling pathway" NARROW [GOC:add] synonym: "IL-1-mediated signaling pathway" EXACT [GOC:mah] synonym: "interleukin-1 alpha-mediated signaling pathway" NARROW [GOC:add] synonym: "interleukin-1 beta-mediated signaling pathway" NARROW [GOC:add] synonym: "interleukin-1-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway is_a: GO:0071347 ! cellular response to interleukin-1 [Term] id: GO:0070499 name: exosporium assembly namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore." [GOC:mah] synonym: "exosporium formation" EXACT [GOC:mah] is_a: GO:0045229 ! external encapsulating structure organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0070500 name: poly-gamma-glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787] synonym: "poly-gamma-glutamate metabolism" EXACT [GOC:mah] is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0070501 name: poly-gamma-glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787] synonym: "poly-gamma-glutamate anabolism" EXACT [GOC:mah] synonym: "poly-gamma-glutamate biosynthesis" EXACT [GOC:mah] synonym: "poly-gamma-glutamate formation" EXACT [GOC:mah] synonym: "poly-gamma-glutamate synthesis" EXACT [GOC:mah] is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0070500 ! poly-gamma-glutamate metabolic process [Term] id: GO:0070502 name: capsule poly-gamma-glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule." [GOC:mah, PMID:16689787] synonym: "capsular poly-gamma-glutamate biosynthetic process" EXACT [GOC:mah] synonym: "capsule poly-gamma-glutamate anabolism" EXACT [GOC:mah] synonym: "capsule poly-gamma-glutamate biosynthesis" EXACT [GOC:mah] synonym: "capsule poly-gamma-glutamate formation" EXACT [GOC:mah] synonym: "capsule poly-gamma-glutamate synthesis" EXACT [GOC:mah] is_a: GO:0045230 ! capsule organization is_a: GO:0070501 ! poly-gamma-glutamate biosynthetic process [Term] id: GO:0070503 name: selenium-containing prosthetic group metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah] synonym: "selenium-containing prosthetic group metabolism" EXACT [GOC:mah] is_a: GO:0001887 ! selenium compound metabolic process is_a: GO:0051189 ! prosthetic group metabolic process [Term] id: GO:0070504 name: selenium-containing prosthetic group biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah] synonym: "selenium-containing prosthetic group anabolism" EXACT [GOC:mah] synonym: "selenium-containing prosthetic group biosynthesis" EXACT [GOC:mah] synonym: "selenium-containing prosthetic group formation" EXACT [GOC:mah] synonym: "selenium-containing prosthetic group synthesis" EXACT [GOC:mah] is_a: GO:0051191 ! prosthetic group biosynthetic process is_a: GO:0070503 ! selenium-containing prosthetic group metabolic process [Term] id: GO:0070505 name: pollen coat namespace: cellular_component def: "A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma." [GOC:mah, GOC:rph, PMID:12930826, PMID:15012271] synonym: "pollenkitt" EXACT [PMID:15012271] synonym: "tryphine" EXACT [PMID:15012271] is_a: GO:0044420 ! extracellular matrix part [Term] id: GO:0070506 name: high-density lipoprotein particle receptor activity namespace: molecular_function def: "Combining with a high-density lipoprotein particle to initiate a change in cell activity." [GOC:BHF, GOC:rl] synonym: "HDL receptor" EXACT [GOC:rl] synonym: "high-density lipoprotein receptor activity" EXACT [GOC:dph] is_a: GO:0008035 ! high-density lipoprotein particle binding is_a: GO:0030228 ! lipoprotein particle receptor activity [Term] id: GO:0070507 name: regulation of microtubule cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051493 ! regulation of cytoskeleton organization relationship: regulates GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0070508 name: cholesterol import namespace: biological_process def: "The directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:rl] synonym: "cholesterol uptake" EXACT [GOC:rl] is_a: GO:0030301 ! cholesterol transport is_a: GO:0035376 ! sterol import [Term] id: GO:0070509 name: calcium ion import namespace: biological_process def: "The directed movement of calcium ions into a cell or organelle." [GOC:mah] synonym: "calcium ion uptake" EXACT [GOC:mah] is_a: GO:0070588 ! calcium ion transmembrane transport [Term] id: GO:0070510 name: regulation of histone H4-K20 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah] is_a: GO:0031060 ! regulation of histone methylation relationship: regulates GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0070511 name: negative regulation of histone H4-K20 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah] synonym: "down regulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "down-regulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "downregulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "inhibition of histone H4-K20 methylation" NARROW [GOC:mah] is_a: GO:0031061 ! negative regulation of histone methylation is_a: GO:0070510 ! regulation of histone H4-K20 methylation relationship: negatively_regulates GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0070512 name: positive regulation of histone H4-K20 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah] synonym: "activation of histone H4-K20 methylation" NARROW [GOC:mah] synonym: "stimulation of histone H4-K20 methylation" NARROW [GOC:mah] synonym: "up regulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "up-regulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "upregulation of histone H4-K20 methylation" EXACT [GOC:mah] is_a: GO:0031062 ! positive regulation of histone methylation is_a: GO:0070510 ! regulation of histone H4-K20 methylation relationship: positively_regulates GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0070513 name: death domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531] comment: For binding to the death effector domain, consider instead the term 'death effector domain binding ; GO:0035877'. is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070514 name: SRF-myogenin-E12 complex namespace: cellular_component def: "A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes." [PMID:8617811] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0070515 name: alphaIIb-beta3 integrin-talin complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin." [PMID:8663236] synonym: "ITGA2b-ITGB3-TLN1 complex" NARROW [CORUM:2378] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070516 name: CAK-ERCC2 complex namespace: cellular_component def: "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842] synonym: "cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070517 name: DNA replication factor C core complex namespace: cellular_component def: "A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37." [PMID:8692848, PMID:9228079, PMID:9582326] subset: goslim_pir synonym: "RFC core complex" EXACT [CORUM:278] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043599 ! nuclear DNA replication factor C complex [Term] id: GO:0070518 name: alpha4-beta1 integrin-CD53 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family." [PMID:8757325] synonym: "ITGA4-ITGB1-CD53 complex" NARROW [CORUM:2420] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070519 name: alpha4-beta1 integrin-CD63 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8757325] synonym: "ITGA4-ITGB1-CD63 complex" NARROW [CORUM:2424] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070520 name: alpha4-beta1 integrin-CD81 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family." [PMID:10229664, PMID:8757325] synonym: "ITGA4-ITGB1-CD81 complex" NARROW [CORUM:2419] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070521 name: alpha4-beta1 integrin-CD82 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family." [PMID:8757325] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070522 name: ERCC4-ERCC1 complex namespace: cellular_component def: "A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae." [PMID:14734547] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "Rad1-Rad10 complex" EXACT [GOC:mah] synonym: "XPF-ERCC1 complex" EXACT [PMID:14734547] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0070523 name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036] is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0070524 name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146] synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146] xref: EC:1.1.1.146 xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0070525 name: threonylcarbamoyladenosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007] synonym: "t6A metabolic process" EXACT [PMID:19287007] synonym: "t6A metabolism" EXACT [PMID:19287007] synonym: "threonylcarbamoyladenosine metabolism" EXACT [GOC:MAH] is_a: GO:0046085 ! adenosine metabolic process [Term] id: GO:0070526 name: threonylcarbamoyladenosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007] synonym: "t6A biosynthesis" EXACT [PMID:19287007] synonym: "t6A biosynthetic process" EXACT [PMID:19287007] synonym: "threonylcarbamoyladenosine anabolism" EXACT [GOC:mah] synonym: "threonylcarbamoyladenosine biosynthesis" EXACT [GOC:mah] synonym: "threonylcarbamoyladenosine formation" EXACT [GOC:mah] synonym: "threonylcarbamoyladenosine synthesis" EXACT [GOC:mah] is_a: GO:0006400 ! tRNA modification is_a: GO:0070525 ! threonylcarbamoyladenosine metabolic process [Term] id: GO:0070527 name: platelet aggregation namespace: biological_process def: "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk] synonym: "blood platelet aggregation" EXACT [CL:0000233] synonym: "thrombocyte aggregation" RELATED [CL:0000233] is_a: GO:0034109 ! homotypic cell-cell adhesion relationship: part_of GO:0030168 ! platelet activation [Term] id: GO:0070528 name: protein kinase C signaling cascade namespace: biological_process def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:mah] synonym: "PKC signaling cascade" EXACT [GOC:mah] synonym: "protein kinase C signalling cascade" EXACT [GOC:mah] is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0070529 name: L-tryptophan aminotransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid." [GOC:mah] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0070530 name: K63-linked polyubiquitin binding namespace: molecular_function def: "Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers." [GOC:mah, PMID:15556404, PMID:17525341] is_a: GO:0031593 ! polyubiquitin binding [Term] id: GO:0070531 name: BRCA1-A complex namespace: cellular_component def: "A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070532 name: BRCA1-B complex namespace: cellular_component def: "A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites." [GOC:mah, PMID:16391231] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070533 name: BRCA1-C complex namespace: cellular_component def: "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070534 name: protein K63-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404] synonym: "protein K63-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination [Term] id: GO:0070535 name: histone H2A K63-linked ubiquitination namespace: biological_process def: "A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:18430235] is_a: GO:0033522 ! histone H2A ubiquitination is_a: GO:0070534 ! protein K63-linked ubiquitination [Term] id: GO:0070536 name: protein K63-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193] xref: Reactome:688986 "protein K63-linked deubiquitination" is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0070537 name: histone H2A K63-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:19202061, PMID:19214193] is_a: GO:0016578 ! histone deubiquitination is_a: GO:0070536 ! protein K63-linked deubiquitination [Term] id: GO:0070538 name: oleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid." [CHEBI:16196, GOC:lp, GOC:mah] is_a: GO:0005504 ! fatty acid binding [Term] id: GO:0070539 name: linoleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid." [CHEBI:17351, GOC:lp, GOC:mah] is_a: GO:0005504 ! fatty acid binding [Term] id: GO:0070540 name: stearic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with stearic acid, the 18-carbon saturated fatty acid octadecanoic acid." [CHEBI:28842, GOC:lp, GOC:mah] is_a: GO:0005504 ! fatty acid binding [Term] id: GO:0070541 name: response to platinum ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:sl] synonym: "response to platinum" EXACT [GOc:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0070542 name: response to fatty acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [CHEBI:35366, GOC:lp] is_a: GO:0033993 ! response to lipid [Term] id: GO:0070543 name: response to linoleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [CHEBI:17351, GOC:lp] synonym: "response to linoleate" EXACT [GOC:mah] is_a: GO:0070542 ! response to fatty acid [Term] id: GO:0070544 name: histone H3-K36 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone." [GOC:sart, PMID:19061644] synonym: "H3K36 demethylation" RELATED [] is_a: GO:0070076 ! histone lysine demethylation [Term] id: GO:0070545 name: PeBoW complex namespace: cellular_component def: "A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively." [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269] is_a: GO:0043234 ! protein complex is_a: GO:0044452 ! nucleolar part relationship: part_of GO:0030686 ! 90S preribosome [Term] id: GO:0070546 name: L-phenylalanine aminotransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid." [GOC:mah] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0070547 name: L-tyrosine aminotransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid." [GOC:mah] subset: gosubset_prok is_a: GO:0008483 ! transaminase activity [Term] id: GO:0070548 name: L-glutamine aminotransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid." [GOC:mah] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0070549 name: negative regulation of translation involved in RNA interference namespace: biological_process def: "A process of negative regulation of translation that is mediated by the association of small interfering RNAs (siRNAs) with a cognate target mRNA." [GOC:mah, PMID:18771919] synonym: "down regulation of translation involved in RNA interference" EXACT [GOC:mah] synonym: "down-regulation of translation involved in RNA interference" EXACT [GOC:mah] synonym: "downregulation of translation involved in RNA interference" EXACT [GOC:mah] synonym: "inhibition of translation involved in RNA interference" NARROW [GOC:mah] synonym: "RNA interference, negative regulation of translation" EXACT [GOC:mah] is_a: GO:0040033 ! negative regulation of translation, ncRNA-mediated relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0070550 name: rDNA condensation namespace: biological_process def: "The cell cycle process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase." [GOC:dgf, PMID:10811823, PMID:15137940] is_a: GO:0007076 ! mitotic chromosome condensation [Term] id: GO:0070551 name: endoribonuclease activity, cleaving siRNA-paired mRNA namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters." [GOC:mah, PMID:15105377] synonym: "argonaute endoribonuclease activity" RELATED [GOC:mah] is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0070552 name: BRISC complex namespace: cellular_component def: "A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070553 name: nicotinic acid receptor activity namespace: molecular_function def: "Combining with nicotinic acid to initiate a change in cell activity." [CHEBI:15940, GOC:mah, PMID:12522134] synonym: "niacin receptor activity" EXACT [CHEBI:15940, GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0070554 name: synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof)." [PMID:8824312] synonym: "SNARE complex (Stx3, Snap25, Vamp2, Cplx1)" NARROW [CORUM:842] synonym: "Stx3-Snap25-Vamp2-Cplx1 complex" NARROW [CORUM:842] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070555 name: response to interleukin-1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:BHF, GOC:mah] synonym: "response to IL-1" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0070556 name: TAF4B-containing transcription factor TFIID complex namespace: cellular_component def: "A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4." [GOC:mah, PMID:8858156] synonym: "TFIID complex, B-cell specific" RELATED [CORUM:485] is_a: GO:0005669 ! transcription factor TFIID complex [Term] id: GO:0070557 name: PCNA-p21 complex namespace: cellular_component def: "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication." [GOC:mah, PMID:7911228, PMID:7915843] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070558 name: alphaM-beta2 integrin-CD63 complex namespace: cellular_component def: "A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8871662] synonym: "ITGAM-ITGB2-CD63 complex" NARROW [CORUM:2153] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070559 name: lysosomal multienzyme complex namespace: cellular_component def: "A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism." [GOC:mah, PMID:8910459] synonym: "GALNS-lysosomal hydrolase 1.27 MDa complex" NARROW [CORUM:1379] is_a: GO:0043234 ! protein complex is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0070560 name: protein secretion by platelet namespace: biological_process def: "The regulated release of proteins by a platelet or group of platelets." [GOC:BHF, GOC:mah] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0070561 name: vitamin D receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah, PMID:12637589] synonym: "VDR signaling pathway" EXACT [PMID:12637589] synonym: "vitamin D receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0030522 ! intracellular receptor mediated signaling pathway is_a: GO:0071305 ! cellular response to vitamin D [Term] id: GO:0070562 name: regulation of vitamin D receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah] synonym: "regulation of VDR signaling pathway" EXACT [PMID:12637589] synonym: "regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels relationship: regulates GO:0070561 ! vitamin D receptor signaling pathway [Term] id: GO:0070563 name: negative regulation of vitamin D receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah] synonym: "down regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "down-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "downregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "inhibition of vitamin D receptor signaling pathway" NARROW [GOC:mah] synonym: "negative regulation of VDR signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of VDR signalling pathway" EXACT [GOC:mah] synonym: "negative regulation vitamin D receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway relationship: negatively_regulates GO:0070561 ! vitamin D receptor signaling pathway [Term] id: GO:0070564 name: positive regulation of vitamin D receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah] synonym: "activation of vitamin D receptor signaling pathway" NARROW [GOC:mah] synonym: "positive regulation of VDR signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah] synonym: "stimulation of vitamin D receptor signaling pathway" NARROW [GOC:mah] synonym: "up regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "up-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "upregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway relationship: positively_regulates GO:0070561 ! vitamin D receptor signaling pathway [Term] id: GO:0070565 name: telomere-telomerase complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome." [GOC:pde, PMID:19179534] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. subset: goslim_pir subset: gosubset_prok is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000781 ! chromosome, telomeric region [Term] id: GO:0070566 name: adenylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah] subset: gosubset_prok is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0070567 name: cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah] subset: gosubset_prok is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0070568 name: guanylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a guanylyl group to an acceptor." [GOC:mah] subset: gosubset_prok is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0070569 name: uridylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah] subset: gosubset_prok is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0070570 name: regulation of neuron projection regeneration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0031102 ! neuron projection regeneration [Term] id: GO:0070571 name: negative regulation of neuron projection regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0070570 ! regulation of neuron projection regeneration relationship: negatively_regulates GO:0031102 ! neuron projection regeneration [Term] id: GO:0070572 name: positive regulation of neuron projection regeneration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0070570 ! regulation of neuron projection regeneration relationship: positively_regulates GO:0031102 ! neuron projection regeneration [Term] id: GO:0070573 name: metallodipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] synonym: "metallo-exo-dipeptidase activity" EXACT [GOC:rb] synonym: "metalloexodipeptidase activity" EXACT [GOC:mah] is_a: GO:0008235 ! metalloexopeptidase activity is_a: GO:0016805 ! dipeptidase activity [Term] id: GO:0070574 name: cadmium ion transmembrane transport namespace: biological_process def: "A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] subset: gosubset_prok synonym: "transmembrane cadmium transport" EXACT [GOC:mah] is_a: GO:0015691 ! cadmium ion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0070575 name: peptide mating pheromone maturation involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation." [GOC:mah] synonym: "peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] synonym: "peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] is_a: GO:0007323 ! peptide pheromone maturation relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation [Term] id: GO:0070576 name: vitamin D 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:mah, PMID:15546903] synonym: "calciferol 24-hydroxylase activity" NARROW [GOC:rl] synonym: "cholecalciferol 24-hydroxylase activity" NARROW [GOC:rl] synonym: "ergocalciferol 24-hydroxylase activity" NARROW [GOC:rl] synonym: "vitamin D2 24-hydroxylase activity" NARROW [GOC:rl] synonym: "vitamin D3 24-hydroxylase activity" NARROW [GOC:rl] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0070577 name: histone acetyl-lysine binding namespace: molecular_function def: "Interacting selectively and non-covalently with an acetylated lysine residue within a histone." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821] synonym: "acetylated histone residue binding" BROAD [GOC:rl] is_a: GO:0042393 ! histone binding [Term] id: GO:0070578 name: RISC-loading complex namespace: cellular_component def: "A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP." [GOC:ab, PMID:18178619] synonym: "microRNA loading complex" EXACT [GOC:ab] synonym: "miRLC" EXACT [GOC:ab] synonym: "RLC" RELATED [GOC:ab, GOC:mah] is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0070579 name: methylcytosine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2." [PMID:19372391] is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0070580 name: base J metabolic process namespace: biological_process def: "The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J." [PMID:19114062] synonym: "base J metabolism" EXACT [GOC:mah] synonym: "beta-D-glucosyl-HOMedU metabolic process" EXACT [GOC:mah] synonym: "beta-D-glucosyl-hydroxymethyluracil metabolism" EXACT [PMID:19114062] is_a: GO:0006206 ! pyrimidine base metabolic process [Term] id: GO:0070581 name: rolling circle DNA replication namespace: biological_process def: "A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon." [GOC:cb, GOC:mah, ISBN:0198506732] synonym: "rolling circle replication" EXACT [GOC:cb] is_a: GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0070582 name: theta DNA replication namespace: biological_process def: "A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template." [GOC:cb, GOC:mah, ISBN:0198506732] synonym: "theta replication" EXACT [GOC:cb] is_a: GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0070583 name: spore membrane bending pathway namespace: biological_process def: "The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore." [GOC:dgf, PMID:18756268] synonym: "ascospore-type prospore membrane bending" EXACT [GOC:mah] synonym: "forespore membrane bending" EXACT [GOC:mah] synonym: "FSM bending" EXACT [GOC:mah] is_a: GO:0016044 ! cellular membrane organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0032120 ! ascospore-type prospore membrane assembly [Term] id: GO:0070584 name: mitochondrion morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah] comment: This term was added by GO_REF:0000021. Note that this term is intended for annotation of gene products involved in mitochondrial shape changes associated with development; an example is the morphogenesis of the Nebenkern during spermatogenesis. is_a: GO:0007005 ! mitochondrion organization is_a: GO:0032990 ! cell part morphogenesis [Term] id: GO:0070585 name: protein localization in mitochondrion namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] synonym: "protein localisation in mitochondrion" EXACT [GOC:mah] synonym: "protein localization to mitochondrion" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0070586 name: cell-cell adhesion involved in gastrulation namespace: biological_process def: "The attachment of one cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770] comment: This term was added by GO_REF:0000021. is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0070587 name: regulation of cell-cell adhesion involved in gastrulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0022407 ! regulation of cell-cell adhesion relationship: regulates GO:0070586 ! cell-cell adhesion involved in gastrulation [Term] id: GO:0070588 name: calcium ion transmembrane transport namespace: biological_process def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] subset: gosubset_prok synonym: "transmembrane calcium transport" EXACT [GOC:mah] is_a: GO:0006816 ! calcium ion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0070589 name: cellular component macromolecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component." [GOC:mah] synonym: "cellular component macromolecule biosynthesis" EXACT [GOC:mah] is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: part_of GO:0044085 ! cellular component biogenesis [Term] id: GO:0070590 name: spore wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore." [GOC:mah] is_a: GO:0042546 ! cell wall biogenesis relationship: part_of GO:0030435 ! sporulation resulting in formation of a cellular spore [Term] id: GO:0070591 name: ascospore wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall." [GOC:mah] is_a: GO:0009272 ! fungal-type cell wall biogenesis is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0070590 ! spore wall biogenesis relationship: part_of GO:0030437 ! ascospore formation [Term] id: GO:0070592 name: cell wall polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall." [GOC:mah] subset: gosubset_prok synonym: "cell wall polysaccharide anabolism" EXACT [GOC:mah] synonym: "cell wall polysaccharide biosynthesis" EXACT [GOC:mah] synonym: "cell wall polysaccharide synthesis" EXACT [GOC:mah] is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process [Term] id: GO:0070593 name: dendrite self-avoidance namespace: biological_process def: "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551] synonym: "dendrite repulsion" EXACT [GOC:sart] is_a: GO:0008038 ! neuron recognition [Term] id: GO:0070594 name: juvenile hormone response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "JHRE binding" EXACT [GOC:mah] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0070595 name: 1,3-alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds." [GOC:mah] synonym: "1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0030978 ! alpha-glucan metabolic process [Term] id: GO:0070596 name: 1,3-alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds." [GOC:mah] synonym: "1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "alpha-1,3 glucan anabolism" EXACT [GOC:mah] synonym: "alpha-1,3 glucan biosynthesis" EXACT [GOC:mah] synonym: "alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah] synonym: "alpha-1,3 glucan formation" EXACT [GOC:mah] synonym: "alpha-1,3 glucan synthesis" EXACT [GOC:mah] is_a: GO:0030979 ! alpha-glucan biosynthetic process is_a: GO:0070595 ! 1,3-alpha-glucan metabolic process [Term] id: GO:0070597 name: cell wall 1,3-alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0070595 ! 1,3-alpha-glucan metabolic process [Term] id: GO:0070598 name: cell wall 1,3-alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1,3-alpha-glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process is_a: GO:0070596 ! 1,3-alpha-glucan biosynthetic process is_a: GO:0070597 ! cell wall 1,3-alpha-glucan metabolic process [Term] id: GO:0070599 name: fungal-type cell wall 1,3-alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0070597 ! cell wall 1,3-alpha-glucan metabolic process [Term] id: GO:0070600 name: fungal-type cell wall 1,3-alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1,3-alpha-glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah] synonym: "fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0070598 ! cell wall 1,3-alpha-glucan biosynthetic process is_a: GO:0070599 ! fungal-type cell wall 1,3-alpha-glucan metabolic process [Term] id: GO:0070601 name: centromeric sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome." [GOC:mah] synonym: "sister chromatid cohesion at centromere" EXACT [GOC:mah] is_a: GO:0007062 ! sister chromatid cohesion [Term] id: GO:0070602 name: regulation of centromeric sister chromatid cohesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome." [GOC:mah] synonym: "regulation of sister chromatid cohesion at centromere" EXACT [GOC:mah] is_a: GO:0007063 ! regulation of sister chromatid cohesion relationship: regulates GO:0070601 ! centromeric sister chromatid cohesion [Term] id: GO:0070603 name: SWI/SNF-type complex namespace: cellular_component def: "A chromatin remodeling complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components." [GOC:mah, PMID:16155938] synonym: "SWI-SNF global transcription activator complex " RELATED [CORUM:224] synonym: "SWI-SNF-type complex" EXACT [GOC:mah] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0070604 name: PBAF complex namespace: cellular_component def: "A SWI/SNF-type complex that contains the ATPase product of the mammalian BAF180 gene." [GOC:mah, PMID:16155938, PMID:8895581] synonym: "Polybromo- and BAF containing complex" EXACT [CORUM:565] synonym: "SWI/SNF complex B" EXACT [CORUM:565] is_a: GO:0070603 ! SWI/SNF-type complex [Term] id: GO:0070605 name: regulation of 1,3-alpha-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds." [GOC:mah] synonym: "regulation of 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0032948 ! regulation of alpha-glucan metabolic process relationship: regulates GO:0070595 ! 1,3-alpha-glucan metabolic process [Term] id: GO:0070606 name: regulation of 1,3-alpha-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds." [GOC:mah] synonym: "regulation of 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "regulation of 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan anabolism" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan formation" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan synthesis" EXACT [GOC:mah] is_a: GO:0032949 ! regulation of alpha-glucan biosynthetic process is_a: GO:0070605 ! regulation of 1,3-alpha-glucan metabolic process relationship: regulates GO:0070596 ! 1,3-alpha-glucan biosynthetic process [Term] id: GO:0070607 name: regulation of cell wall 1,3-alpha-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0070605 ! regulation of 1,3-alpha-glucan metabolic process relationship: regulates GO:0070597 ! cell wall 1,3-alpha-glucan metabolic process [Term] id: GO:0070608 name: regulation of cell wall 1,3-alpha-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of 1,3-alpha-glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0070606 ! regulation of 1,3-alpha-glucan biosynthetic process is_a: GO:0070607 ! regulation of cell wall 1,3-alpha-glucan metabolic process relationship: regulates GO:0070598 ! cell wall 1,3-alpha-glucan biosynthetic process [Term] id: GO:0070609 name: regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "regulation of ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "regulation of ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "regulation of ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0070607 ! regulation of cell wall 1,3-alpha-glucan metabolic process relationship: regulates GO:0070599 ! fungal-type cell wall 1,3-alpha-glucan metabolic process [Term] id: GO:0070610 name: regulation of fungal-type cell wall 1,3-alpha-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of 1,3-alpha-glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah] synonym: "regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0070608 ! regulation of cell wall 1,3-alpha-glucan biosynthetic process is_a: GO:0070609 ! regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process relationship: regulates GO:0070600 ! fungal-type cell wall 1,3-alpha-glucan biosynthetic process [Term] id: GO:0070611 name: histone methyltransferase activity (H3-R2 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3." [EC:2.1.1.125, GOC:mah, PMID:17898714] synonym: "histone methylase activity (H3-R2 specific)" EXACT [GOC:mah] synonym: "histone-arginine N-methyltransferase activity (H3-R2 specific)" EXACT [GOC:mah] is_a: GO:0008469 ! histone-arginine N-methyltransferase activity [Term] id: GO:0070612 name: histone methyltransferase activity (H2A-R3 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A." [EC:2.1.1.125, GOC:mah, PMID:17898714] synonym: "histone methylase activity (H2A-R3 specific)" EXACT [GOC:mah] synonym: "histone-arginine N-methyltransferase activity (H2A-R3 specific)" EXACT [GOC:mah] is_a: GO:0008469 ! histone-arginine N-methyltransferase activity [Term] id: GO:0070613 name: regulation of protein processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein processing, the posttranslational modification of a protein leading to the attainment of the full functional capacity of the protein." [GOC:mah] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051246 ! regulation of protein metabolic process relationship: regulates GO:0016485 ! protein processing [Term] id: GO:0070614 name: tungstate ion transport namespace: biological_process def: "The directed movement of tungstate (WO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten." [GOC:dh] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0070615 name: nucleosome-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes." [GOC:mah, PMID:19165147] synonym: "nucleosome-activated ATPase activity" EXACT [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0070616 name: regulation of thiamine diphosphate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah] subset: gosubset_prok synonym: "regulation of thiamin diphosphate biosynthetic process" EXACT [GOC:curators] synonym: "regulation of thiamine diphosphate anabolism" EXACT [GOC:mah] synonym: "regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah] synonym: "regulation of thiamine diphosphate formation" EXACT [GOC:mah] synonym: "regulation of thiamine diphosphate synthesis" EXACT [GOC:mah] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process relationship: regulates GO:0009229 ! thiamine diphosphate biosynthetic process [Term] id: GO:0070617 name: negative regulation of thiamine diphosphate biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah] subset: gosubset_prok synonym: "down regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of thiamine diphosphate biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of thiamin diphosphate biosynthetic process" EXACT [GOC:curators] synonym: "negative regulation of thiamine diphosphate anabolism" EXACT [GOC:mah] synonym: "negative regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of thiamine diphosphate formation" EXACT [GOC:mah] synonym: "negative regulation of thiamine diphosphate synthesis" EXACT [GOC:mah] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0070616 ! regulation of thiamine diphosphate biosynthetic process relationship: negatively_regulates GO:0009229 ! thiamine diphosphate biosynthetic process [Term] id: GO:0070618 name: Grb2-Sos complex namespace: cellular_component def: "A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013] synonym: "Grb2-mSos1 complex" NARROW [CORUM:2545] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070619 name: Shc-Grb2-Sos complex namespace: cellular_component def: "A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7970708, PMID:8940013] synonym: "Shc-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2553] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070620 name: EGFR-Grb2-Sos complex namespace: cellular_component def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013] synonym: "Egfr-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2548] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070621 name: EGFR-Shc-Grb2-Sos complex namespace: cellular_component def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070622 name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex namespace: cellular_component def: "A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits." [GOC:mah, PMID:8940155] synonym: "N-acetylglucosamine-1-phosphotransferase complex" RELATED [CORUM:406] synonym: "UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex" EXACT [PMID:8940155] is_a: GO:0043234 ! protein complex is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0070623 name: regulation of thiamine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah] subset: gosubset_prok synonym: "regulation of thiamin biosynthetic process" EXACT [GOC:curators] synonym: "regulation of thiamine anabolism" EXACT [GOC:mah] synonym: "regulation of thiamine biosynthesis" EXACT [GOC:mah] synonym: "regulation of thiamine formation" EXACT [GOC:mah] synonym: "regulation of thiamine synthesis" EXACT [GOC:mah] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: regulates GO:0009228 ! thiamine biosynthetic process [Term] id: GO:0070624 name: negative regulation of thiamine biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah] subset: gosubset_prok synonym: "down regulation of thiamine biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of thiamine biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of thiamine biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of thiamine biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of thiamin biosynthetic process" EXACT [GOC:curators] synonym: "negative regulation of thiamine anabolism" EXACT [GOC:mah] synonym: "negative regulation of thiamine biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of thiamine formation" EXACT [GOC:mah] synonym: "negative regulation of thiamine synthesis" EXACT [GOC:mah] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0070623 ! regulation of thiamine biosynthetic process relationship: negatively_regulates GO:0009228 ! thiamine biosynthetic process [Term] id: GO:0070625 name: zymogen granule exocytosis namespace: biological_process def: "The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions." [GOC:BHF, GOC:vk, PMID:17442889] is_a: GO:0017156 ! calcium ion-dependent exocytosis [Term] id: GO:0070626 name: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah] synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah] synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] xref: EC:4.3.2.2 xref: KEGG:R04559 xref: MetaCyc:AICARSYN-RXN is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0070627 name: ferrous iron import namespace: biological_process def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions across a membrane into a cell or organelle." [GOC:mah] synonym: "ferrous ion import" EXACT [] synonym: "ferrous iron uptake" EXACT [] is_a: GO:0015684 ! ferrous iron transport is_a: GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0070628 name: proteasome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0070629 name: 1,4-alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-1,4 glucans, compounds composed of glucose residues linked by 1,4-alpha-D-glucosidic bonds." [GOC:mah] subset: gosubset_prok synonym: "1,4-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "alpha-1,4 glucan metabolic process" EXACT [GOC:mah] synonym: "alpha-1,4 glucan metabolism" EXACT [GOC:mah] is_a: GO:0030978 ! alpha-glucan metabolic process [Term] id: GO:0070630 name: 1,4-alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-1,4 glucans, compounds composed of glucose residues linked by 1,4-alpha-D-glucosidic bonds." [GOC:mah] synonym: "1,4-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "1,4-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "1,4-alpha-glucan formation" EXACT [GOC:mah] synonym: "1,4-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "alpha-1,4 glucan anabolism" EXACT [GOC:mah] synonym: "alpha-1,4 glucan biosynthesis" EXACT [GOC:mah] synonym: "alpha-1,4 glucan biosynthetic process" EXACT [GOC:mah] synonym: "alpha-1,4 glucan formation" EXACT [GOC:mah] synonym: "alpha-1,4 glucan synthesis" EXACT [GOC:mah] is_a: GO:0030979 ! alpha-glucan biosynthetic process is_a: GO:0070629 ! 1,4-alpha-glucan metabolic process [Term] id: GO:0070631 name: spindle pole body localization namespace: biological_process def: "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah] synonym: "establishment and maintenance of spindle pole body localization" EXACT [GOC:mah] synonym: "spindle pole body localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization [Term] id: GO:0070632 name: establishment of spindle pole body localization namespace: biological_process def: "Any process in which a spindle pole body is transported to a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah] synonym: "establishment of spindle pole body localisation" EXACT [GOC:mah] synonym: "spindle pole body positioning" EXACT [GOC:vw] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0070631 ! spindle pole body localization [Term] id: GO:0070633 name: transepithelial transport namespace: biological_process def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, ISBN:0716731363] is_a: GO:0006810 ! transport [Term] id: GO:0070634 name: transepithelial ammonium transport namespace: biological_process def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf] is_a: GO:0015696 ! ammonium transport is_a: GO:0070633 ! transepithelial transport [Term] id: GO:0070635 name: nicotinamide riboside hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose." [MetaCyc:RXN-8441, PMID:19001417] synonym: "N-ribosylnicotinamide hydrolase activity" EXACT [CHEBI:15927] synonym: "nicotinamide ribonucleoside hydrolase activity" EXACT [CHEBI:15927] xref: EC:3.2.2.- xref: MetaCyc:RXN-8441 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0070636 name: nicotinic acid riboside hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose." [GOC:mah, PMID:19001417] synonym: "D-ribosylnicotinate hydrolase activity" EXACT [GOC:mah] synonym: "D-ribosylnicotinic acid hydrolase activity" EXACT [CHEBI:27748] synonym: "nicotinate ribonucleoside hydrolase activity" EXACT [GOC:mah] synonym: "nicotinate riboside hydrolase activity" EXACT [GOC:mah] synonym: "nicotinic acid ribonucleoside hydrolase activity" EXACT [GOC:mah] xref: EC:3.2.2.- is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0070637 name: pyridine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [CHEBI:47896, GOC:mah] subset: gosubset_prok synonym: "pyridine nucleoside metabolism" EXACT [GOC:mah] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0070638 name: pyridine nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [CHEBI:47896, GOC:mah] subset: gosubset_prok synonym: "pyridine nucleoside breakdown" EXACT [GOC:mah] synonym: "pyridine nucleoside catabolism" EXACT [GOC:mah] synonym: "pyridine nucleoside degradation" EXACT [GOC:mah] is_a: GO:0009164 ! nucleoside catabolic process is_a: GO:0070637 ! pyridine nucleoside metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process [Term] id: GO:0070639 name: vitamin D2 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol." [CHEBI:28934, GOC:BHF, GOC:mah] synonym: "calciferol metabolic process" EXACT [CHEBI:28934] synonym: "ergocalciferol metabolic process" EXACT [CHEBI:28934] synonym: "vitamin D2 metabolism" EXACT [GOC:mah] is_a: GO:0042359 ! vitamin D metabolic process [Term] id: GO:0070640 name: vitamin D3 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol." [CHEBI:28940, GOC:BHF, GOC:mah] synonym: "calciol metabolic process" EXACT [CHEBI:28940] synonym: "cholecalciferol metabolic process" EXACT [CHEBI:28940] synonym: "vitamin D3 metabolism" EXACT [GOC:mah] is_a: GO:0042359 ! vitamin D metabolic process [Term] id: GO:0070641 name: vitamin D4 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol." [CHEBI:33237, GOC:BHF, GOC:mah] synonym: "vitamin D4 metabolism" EXACT [GOC:mah] is_a: GO:0042359 ! vitamin D metabolic process [Term] id: GO:0070642 name: vitamin D5 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol." [GOC:BHF, GOC:mah, PubChem_Compound:9547700] synonym: "vitamin D5 metabolism" EXACT [GOC:mah] is_a: GO:0042359 ! vitamin D metabolic process [Term] id: GO:0070643 name: vitamin D 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-25 of any form of vitamin D." [GOC:BHF, GOC:mah] synonym: "calciferol 25-hydroxylase activity" NARROW [GOC:mah] synonym: "cholecalciferol 25-hydroxylase activity" NARROW [GOC:mah] synonym: "ergocalciferol 25-hydroxylase activity" NARROW [GOC:mah] synonym: "vitamin D2 25-hydroxylase activity" NARROW [GOC:mah] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0070644 name: vitamin D response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:vk, PMID:17426122] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "VDRE binding" EXACT [GOC:vk, PMID:17426122] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0070645 name: Ubisch body namespace: cellular_component def: "A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development." [GOC:ecd, GOC:mah, PMID:14612572, PMID:16524248] synonym: "orbicule" EXACT [PMID:14612572] is_a: GO:0044420 ! extracellular matrix part [Term] id: GO:0070646 name: protein modification by small protein removal namespace: biological_process def: "A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein." [GOC:mah] is_a: GO:0070647 ! protein modification by small protein conjugation or removal [Term] id: GO:0070647 name: protein modification by small protein conjugation or removal namespace: biological_process def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] subset: goslim_pombe is_a: GO:0006464 ! protein modification process [Term] id: GO:0070648 name: formin-nucleated actin cable namespace: cellular_component def: "An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth." [PMID:14671023, PMID:16959963] is_a: GO:0032432 ! actin filament bundle [Term] id: GO:0070649 name: formin-nucleated actin cable assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:mah, PMID:14671023, PMID:16959963] synonym: "formin-nucleated actin cable formation" EXACT [GOC:mah] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0070650 name: actin filament bundle distribution namespace: biological_process def: "Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell." [GOC:mah] is_a: GO:0007015 ! actin filament organization [Term] id: GO:0070651 name: nonfunctional rRNA decay namespace: biological_process def: "An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system." [GOC:mah, GOC:rn, PMID:17188037, PMID:19390089] synonym: "NRD" RELATED [GOC:rn] is_a: GO:0016075 ! rRNA catabolic process [Term] id: GO:0070652 name: HAUS complex namespace: cellular_component def: "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217] synonym: "HAUS augmin complex" EXACT [GOC:mm2] is_a: GO:0005875 ! microtubule associated complex [Term] id: GO:0070653 name: high-density lipoprotein particle receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a high-density lipoprotein receptor." [GOC:BHF, GOC:mah] synonym: "HDL receptor binding" EXACT [GOC:mah] synonym: "high-density lipoprotein receptor binding" EXACT [GOC:dph] is_a: GO:0070325 ! lipoprotein particle receptor binding [Term] id: GO:0070654 name: sensory epithelium regeneration namespace: biological_process def: "The regrowth of a sensory epithelium following its loss or destruction." [GOC:dsf, PMID:19381250] is_a: GO:0042246 ! tissue regeneration [Term] id: GO:0070655 name: mechanosensory epithelium regeneration namespace: biological_process def: "The regrowth of lost or destroyed mechanosensory epithelia." [GOC:dsf, PMID:19381250] is_a: GO:0070654 ! sensory epithelium regeneration [Term] id: GO:0070656 name: mechanoreceptor differentiation involved in mechanosensory epithelium regeneration namespace: biological_process def: "Differentiation of new mechanoreceptors to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250] is_a: GO:0042490 ! mechanoreceptor differentiation relationship: part_of GO:0070655 ! mechanosensory epithelium regeneration [Term] id: GO:0070657 name: neuromast regeneration namespace: biological_process def: "The regrowth of a neuromast following its loss or destruction." [GOC:dsf, PMID:19381250] is_a: GO:0070655 ! mechanosensory epithelium regeneration [Term] id: GO:0070658 name: neuromast hair cell differentiation involved in neuromast regeneration namespace: biological_process def: "Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250] is_a: GO:0048886 ! neuromast hair cell differentiation is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration relationship: part_of GO:0070657 ! neuromast regeneration [Term] id: GO:0070659 name: inner ear sensory epithelium regeneration namespace: biological_process def: "The regrowth of lost or destroyed inner ear sensory epithelia." [GOC:dsf, PMID:19381250] is_a: GO:0070655 ! mechanosensory epithelium regeneration [Term] id: GO:0070660 name: inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration namespace: biological_process def: "Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250] is_a: GO:0060113 ! inner ear receptor cell differentiation is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration relationship: part_of GO:0070659 ! inner ear sensory epithelium regeneration [Term] id: GO:0070661 name: leukocyte proliferation namespace: biological_process def: "The expansion of a leukocyte population by cell division." [GOC:add] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0070662 name: mast cell proliferation namespace: biological_process def: "The expansion of a mast cell population by cell division." [GOC:add] is_a: GO:0070661 ! leukocyte proliferation [Term] id: GO:0070663 name: regulation of leukocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0070661 ! leukocyte proliferation [Term] id: GO:0070664 name: negative regulation of leukocyte proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation relationship: negatively_regulates GO:0070661 ! leukocyte proliferation [Term] id: GO:0070665 name: positive regulation of leukocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "activation of leukocyte proliferation" NARROW [GOC:mah] synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah] synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation relationship: positively_regulates GO:0070661 ! leukocyte proliferation [Term] id: GO:0070666 name: regulation of mast cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mast cell proliferation." [GOC:add, GOC:mah] is_a: GO:0070663 ! regulation of leukocyte proliferation relationship: regulates GO:0070662 ! mast cell proliferation [Term] id: GO:0070667 name: negative regulation of mast cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mast cell proliferation." [GOC:add, GOC:mah] synonym: "down regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "downregulation of mast cell proliferation" EXACT [GOC:mah] synonym: "inhibition of mast cell proliferation" NARROW [GOC:mah] is_a: GO:0070664 ! negative regulation of leukocyte proliferation is_a: GO:0070666 ! regulation of mast cell proliferation relationship: negatively_regulates GO:0070662 ! mast cell proliferation [Term] id: GO:0070668 name: positive regulation of mast cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of mast cell proliferation." [GOC:add, GOC:mah] synonym: "activation of mast cell proliferation" NARROW [GOC:mah] synonym: "stimulation of mast cell proliferation" NARROW [GOC:mah] synonym: "up regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "upregulation of mast cell proliferation" EXACT [GOC:mah] is_a: GO:0070665 ! positive regulation of leukocyte proliferation is_a: GO:0070666 ! regulation of mast cell proliferation relationship: positively_regulates GO:0070662 ! mast cell proliferation [Term] id: GO:0070669 name: response to interleukin-2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah] synonym: "response to IL-2" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0070670 name: response to interleukin-4 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah] synonym: "response to IL-4" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0070671 name: response to interleukin-12 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah] synonym: "response to IL-12" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0070672 name: response to interleukin-15 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah] synonym: "response to IL-15" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0070673 name: response to interleukin-18 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah] synonym: "response to IL-18" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0070674 name: hypoxanthine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "hypoxanthine oxidoreductase activity" BROAD [EC:1.17.1.4] synonym: "hypoxanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "hypoxanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "hypoxanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "hypoxanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "NAD-hypoxanthine dehydrogenase activity" EXACT [EC:1.17.1.4] is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0070675 name: hypoxanthine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2." [GOC:mah, GOC:pde] subset: gosubset_prok synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2] synonym: "hypoxanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "hypoxanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "hypoxanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: GO:0070676 name: intralumenal vesicle formation namespace: biological_process def: "The evagination of the endosome membrane, resulting in the formation of a vesicle." [GOC:jp, PMID:19234443] synonym: "endosome membrane budding" EXACT [GOC:jp, GOC:mah] is_a: GO:0006900 ! membrane budding [Term] id: GO:0070677 name: rRNA (cytosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine." [GOC:mah, PMID:19400805] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity [Term] id: GO:0070678 name: preprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing." [GOC:imk, GOC:mah, PMID:12914940] synonym: "unprocessed protein binding" EXACT [GOC:imk] is_a: GO:0005515 ! protein binding [Term] id: GO:0070679 name: inositol 1,4,5 trisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah] subset: gosubset_prok synonym: "InsP3 binding" EXACT [GOC:mah] synonym: "IP3 binding" EXACT [GOC:mah] is_a: GO:0043178 ! alcohol binding [Term] id: GO:0070680 name: asparaginyl-tRNAAsn biosynthesis via transamidation namespace: biological_process def: "A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase." [GOC:mah, MetaCyc:PWY490-4] xref: MetaCyc:PWY490-4 is_a: GO:0043039 ! tRNA aminoacylation [Term] id: GO:0070681 name: glutaminyl-tRNAGln biosynthesis via transamidation namespace: biological_process def: "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921] xref: MetaCyc:PWY-5921 is_a: GO:0043039 ! tRNA aminoacylation [Term] id: GO:0070682 name: proteasome regulatory particle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex." [GOC:mah, GOC:rb, PMID:19412159] synonym: "proteasome regulatory complex assembly" EXACT [GOC:mah] is_a: GO:0043248 ! proteasome assembly [Term] id: GO:0070683 name: mitotic cell cycle G2/M transition decatenation checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until sister chromatids are sufficiently separated, with concatenated molecules topologically resolved." [GOC:jp, GOC:mah] synonym: "topo II checkpoint" EXACT [GOC:jp] synonym: "topoisomerase II checkpoint" EXACT [GOC:jp] is_a: GO:0071780 ! mitotic cell cycle G2/M transition checkpoint [Term] id: GO:0070684 name: seminal clot liquefaction namespace: biological_process def: "The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa." [GOC:mah, PMID:18482984] synonym: "semen liquefaction" EXACT [PMID:18482984] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007320 ! insemination [Term] id: GO:0070685 name: macropinocytic cup namespace: cellular_component def: "A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin." [PMID:12538772, PMID:16968738, PMID:9044041] synonym: "crown" EXACT [GOC:pf, PMID:9044041] is_a: GO:0042995 ! cell projection [Term] id: GO:0070686 name: macropinocytic cup membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a macropinocytic cup." [GOC:mah] synonym: "crown membrane" EXACT [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0070685 ! macropinocytic cup [Term] id: GO:0070687 name: macropinocytic cup cytoskeleton namespace: cellular_component def: "The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup." [GOC:mah] synonym: "crown cytoskeleton" EXACT [GOC:mah] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0030864 ! cortical actin cytoskeleton relationship: part_of GO:0070685 ! macropinocytic cup [Term] id: GO:0070688 name: MLL5-L complex namespace: cellular_component def: "A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively." [GOC:mah, PMID:19377461] is_a: GO:0035097 ! histone methyltransferase complex [Term] id: GO:0070689 name: threonine catabolic process to propionate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound propionate." [GOC:mah, MetaCyc:PWY-5437] subset: gosubset_prok synonym: "threonine breakdown to propionate" EXACT [GOC:mah] synonym: "threonine catabolism to propionate" EXACT [GOC:mah] synonym: "threonine degradation to propionate" EXACT [GOC:mah] xref: MetaCyc:PWY-5437 is_a: GO:0006567 ! threonine catabolic process [Term] id: GO:0070690 name: threonine catabolic process to acetyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound acetyl-Coenzyme A." [GOC:mah, MetaCyc:PWY-5436] subset: gosubset_prok synonym: "threonine breakdown to acetyl-CoA" EXACT [GOC:mah] synonym: "threonine catabolism to acetyl-CoA" EXACT [GOC:mah] synonym: "threonine degradation to acetyl-CoA" EXACT [GOC:mah] xref: MetaCyc:PWY-5436 is_a: GO:0006567 ! threonine catabolic process [Term] id: GO:0070691 name: dimeric positive transcription elongation factor complex b namespace: cellular_component def: "A positive transcription elongation factor complex b that comprises two subunits; an example is the budding yeast complex containing Svg1p (also called Bur1p) and Bur2p." [GOC:mah, PMID:16721054, PMID:19328067] synonym: "Bur1/Bur2 complex" NARROW [PMID:16721054, PMID:19328067] synonym: "Sgv1/Bur2 complex" NARROW [GOC:mah] is_a: GO:0008024 ! positive transcription elongation factor complex b [Term] id: GO:0070692 name: trimeric positive transcription elongation factor complex b namespace: cellular_component def: "A positive transcription elongation factor complex b that comprises three subunits; an example is the budding yeast Ctk complex, which consists of Ctk1p, Ctk2p and Ctk3p." [GOC:mah, PMID:16721054, PMID:19328067] synonym: "CTDK-I complex" NARROW [PMID:16721054, PMID:19328067] synonym: "Ctk complex" NARROW [PMID:16721054] is_a: GO:0008024 ! positive transcription elongation factor complex b [Term] id: GO:0070693 name: P-TEFb-cap methyltransferase complex namespace: cellular_component def: "A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase." [PMID:17332744, PMID:19328067] synonym: "Cdk9-Pcm1 complex" NARROW [GOC:vw] synonym: "P-TEFb-Pcm1 complex" NARROW [GOC:vw] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070694 name: deoxyribonucleoside 5'-monophosphate N-glycosidase activity namespace: molecular_function def: "Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base." [GOC:ab, PMID:17234634] subset: gosubset_prok synonym: "deoxynucleoside 5'-monophosphate N-glycosidase activity" EXACT [] xref: EC:3.2.2.- xref: IMG:03312 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0070695 name: FHF complex namespace: cellular_component def: "A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex)." [GOC:ab, GOC:mah, PMID:18799622] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070696 name: transmembrane receptor protein serine/threonine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity." [GOC:BHF, GOC:mah] is_a: GO:0033612 ! receptor serine/threonine kinase binding [Term] id: GO:0070697 name: activin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an activin receptor." [GOC:BHF, GOC:vk] is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding [Term] id: GO:0070698 name: type I activin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type I activin receptor." [GOC:BHF, GOC:vk] is_a: GO:0070697 ! activin receptor binding [Term] id: GO:0070699 name: type II activin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type II activin receptor." [GOC:BHF, GOC:vk] is_a: GO:0070697 ! activin receptor binding [Term] id: GO:0070700 name: BMP receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a BMP receptor." [GOC:BHF, GOC:vk] synonym: "bone morphogenetic protein receptor binding" EXACT [GOC:mah] is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding [Term] id: GO:0070701 name: mucus layer namespace: cellular_component def: "An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394] is_a: GO:0044421 ! extracellular region part [Term] id: GO:0070702 name: inner mucus layer namespace: cellular_component def: "The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394] is_a: GO:0070701 ! mucus layer [Term] id: GO:0070703 name: outer mucus layer namespace: cellular_component def: "The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394] is_a: GO:0070701 ! mucus layer [Term] id: GO:0070704 name: sterol desaturase activity namespace: molecular_function def: "Catalysis of the introduction of a double bond into a sterol molecule." [GOC:mah, GOC:vw] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0070705 name: RNA nucleotide insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of one or more nucleotides." [GOC:cb, GOC:mah] is_a: GO:0009451 ! RNA modification [Term] id: GO:0070706 name: RNA nucleotide deletion namespace: biological_process def: "The modification of an RNA molecule by removal of a single nucleotide." [GOC:cb, GOC:mah] synonym: "RNA nucleotide excision" EXACT [GOC:cb, GOC:mah] is_a: GO:0009451 ! RNA modification [Term] id: GO:0070707 name: RNA dinucleotide insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of a dinucleotide." [GOC:cb, GOC:mah] is_a: GO:0070705 ! RNA nucleotide insertion [Term] id: GO:0070708 name: RNA cytidine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of a cytidine nucleotide." [GOC:cb, GOC:mah] synonym: "RNA C insertion" EXACT [GOC:mah] is_a: GO:0070705 ! RNA nucleotide insertion [Term] id: GO:0070709 name: RNA guanosine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of a guanosine nucleotide." [GOC:cb, GOC:mah] synonym: "RNA G insertion" EXACT [GOC:mah] is_a: GO:0070705 ! RNA nucleotide insertion [Term] id: GO:0070710 name: RNA uridine deletion namespace: biological_process def: "The modification of an RNA molecule by removal of a uridine nucleotide." [GOC:cb, GOC:mah] synonym: "RNA U deletion" EXACT [GOC:mah] synonym: "RNA uridine excision" EXACT [GOC:cb, GOC:mah] is_a: GO:0070706 ! RNA nucleotide deletion [Term] id: GO:0070711 name: RNA adenosine-uridine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide." [GOC:cb, GOC:mah] synonym: "RNA AU insertion" EXACT [GOC:mah] is_a: GO:0070707 ! RNA dinucleotide insertion [Term] id: GO:0070712 name: RNA cytidine-uridine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide." [GOC:cb, GOC:mah] synonym: "RNA CU insertion" EXACT [GOC:mah] is_a: GO:0070707 ! RNA dinucleotide insertion [Term] id: GO:0070713 name: RNA guanosine-cytidine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide." [GOC:cb, GOC:mah] synonym: "RNA GC insertion" EXACT [GOC:mah] is_a: GO:0070707 ! RNA dinucleotide insertion [Term] id: GO:0070714 name: RNA guanosine-uridine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide." [GOC:cb, GOC:mah] synonym: "RNA GU insertion" EXACT [GOC:mah] is_a: GO:0070707 ! RNA dinucleotide insertion [Term] id: GO:0070715 name: sodium-dependent organic cation transport namespace: biological_process def: "The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] is_a: GO:0015695 ! organic cation transport [Term] id: GO:0070716 name: mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication namespace: biological_process def: "A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication." [GOC:BHF, GOC:mah] subset: gosubset_prok synonym: "mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] is_a: GO:0006298 ! mismatch repair is_a: GO:0045005 ! maintenance of fidelity involved in DNA-dependent DNA replication [Term] id: GO:0070717 name: poly-purine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah] is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0070718 name: alphaPDGFR-SHP-2 complex namespace: cellular_component def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348] synonym: "PDGFRA-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3183] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070719 name: alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex namespace: cellular_component def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348] synonym: "PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated" NARROW [CORUM:2551] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070720 name: Grb2-SHP-2 complex namespace: cellular_component def: "A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348] synonym: "GRB2-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3186] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070721 name: ISGF3 complex namespace: cellular_component def: "A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein." [GOC:mah, PMID:8943351] synonym: "interferon-stimulated gene factor 3 transcription complex" EXACT [CORUM:60] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0070722 name: Tle3-Aes complex namespace: cellular_component def: "A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product." [GOC:mah, PMID:8955148] synonym: "Grg3b-Grg5 complex" EXACT [CORUM:3130, PMID:8955148] is_a: GO:0017053 ! transcriptional repressor complex [Term] id: GO:0070723 name: response to cholesterol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:BHF, GOC:vk] is_a: GO:0033993 ! response to lipid [Term] id: GO:0070724 name: BMP receptor complex namespace: cellular_component def: "A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits." [GOC:mah, GOC:mh, PMID:19377468] synonym: "bone morphogenetic protein receptor complex" EXACT [GOC:mah] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0070725 name: Yb body namespace: cellular_component def: "A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell." [GOC:sart, PMID:19433453] is_a: GO:0044424 ! intracellular part [Term] id: GO:0070726 name: cell wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells." [GOC:mah] is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0042546 ! cell wall biogenesis [Term] id: GO:0070727 name: cellular macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular macromolecule localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization [Term] id: GO:0070728 name: leucine binding namespace: molecular_function def: "Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid." [CHEBI:25017, GOC:BHF, GOC:mah] synonym: "Leu binding" EXACT [GOC:mah] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0070729 name: cyclic nucleotide transport namespace: biological_process def: "The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0006862 ! nucleotide transport [Term] id: GO:0070730 name: cAMP transport namespace: biological_process def: "The directed movement of cyclic AMP (cAMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "cyclic AMP transport" EXACT [GOC:mah] is_a: GO:0070729 ! cyclic nucleotide transport [Term] id: GO:0070731 name: cGMP transport namespace: biological_process def: "The directed movement of cyclic GMP (cGMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "cyclic GMP transport" EXACT [GOC:mah] is_a: GO:0070729 ! cyclic nucleotide transport [Term] id: GO:0070732 name: spindle envelope namespace: cellular_component def: "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889] subset: goslim_candida is_a: GO:0031967 ! organelle envelope [Term] id: GO:0070733 name: protein adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins." [GOC:mah, PMID:19039103, PMID:19362538] subset: gosubset_prok synonym: "adenosine monophosphate-protein transferase activity" EXACT [GOC:mah] synonym: "AMPylator" RELATED [GOC:mah] is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0070734 name: histone H3-K27 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:mah] synonym: "histone H3 K27 methylation" EXACT [GOC:mah] synonym: "histone H3K27me" EXACT [GOC:mah] synonym: "histone lysine H3 K27 methylation" EXACT [GOC:mah] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0070735 name: protein-glycine ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein." [GOC:mah, PMID:19524510] synonym: "protein glycylase activity" EXACT [GOC:mah] xref: EC:6.3.2.- is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0070736 name: protein-glycine ligase activity, initiating namespace: molecular_function def: "Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein." [GOC:mah, PMID:19524510] synonym: "protein glycylase activity, initiating" EXACT [GOC:mah] xref: EC:6.3.2.- is_a: GO:0070735 ! protein-glycine ligase activity [Term] id: GO:0070737 name: protein-glycine ligase activity, elongating namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain." [GOC:mah, PMID:19524510] synonym: "protein glycylase activity, elongating" EXACT [GOC:mah] xref: EC:6.3.2.- is_a: GO:0070735 ! protein-glycine ligase activity [Term] id: GO:0070738 name: tubulin-glycine ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin." [GOC:mah, PMID:19524510] synonym: "tubulin glycylase activity" EXACT [GOC:mah] xref: EC:6.3.2.- is_a: GO:0070735 ! protein-glycine ligase activity [Term] id: GO:0070739 name: protein-glutamic acid ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein." [GOC:mah, PMID:19524510] synonym: "protein glutamylase activity" EXACT [GOC:mah] synonym: "protein-glutamate ligase activity" EXACT [GOC:mah] xref: EC:6.3.2.- is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0070740 name: tubulin-glutamic acid ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510] synonym: "tubulin glutamylase activity" EXACT [GOC:mah] synonym: "tubulin-glutamate ligase activity" EXACT [GOC:mah] xref: EC:6.3.2.- is_a: GO:0070739 ! protein-glutamic acid ligase activity [Term] id: GO:0070741 name: response to interleukin-6 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] synonym: "response to IL-6" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0070742 name: C2H2 zinc finger domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion." [GOC:BHF, GOC:mah, Pfam:PF00096] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070743 name: interleukin-23 complex namespace: cellular_component def: "A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space." [GOC:add, PMID:11114383, PMID:15999093] comment: Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12. synonym: "IL-23 complex" EXACT [GOC:add] synonym: "IL12B" NARROW [GOC:add] synonym: "IL23A" NARROW [GOC:add] synonym: "p19" NARROW [GOC:add] synonym: "p40" NARROW [GOC:add] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0070744 name: interleukin-27 complex namespace: cellular_component def: "A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:15999093, PMID:19161428] comment: Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits. synonym: "EBI3" NARROW [GOC:add] synonym: "IL-27 complex" EXACT [GOC:add] synonym: "IL27" NARROW [GOC:add] synonym: "p28" NARROW [GOC:add] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0070745 name: interleukin-35 complex namespace: cellular_component def: "A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:19161428, PMID:19161429] comment: Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene. synonym: "EBI3" NARROW [GOC:add] synonym: "IL-35 complex" EXACT [GOC:add] synonym: "IL12A" NARROW [GOC:add] synonym: "p35" NARROW [GOC:add] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0070746 name: interleukin-35 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-35." [GOC:add] synonym: "IL-35 binding" EXACT [GOC:add] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0070747 name: interleukin-35 receptor activity namespace: molecular_function def: "Combining with interleukin-35 to initiate a change in cell activity." [GOC:add] synonym: "IL-35 receptor activity" EXACT [GOC:add] synonym: "IL-35R" EXACT [GOC:add] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0070746 ! interleukin-35 binding [Term] id: GO:0070748 name: interleukin-35 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-35 receptor." [GOC:add] synonym: "IL-35" NARROW [GOC:add] synonym: "interleukin-35 receptor ligand" NARROW [GOC:add] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0070749 name: interleukin-35 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] synonym: "IL-35 biosynthesis" EXACT [GOC:mah] synonym: "IL-35 biosynthetic process" EXACT [GOC:add] synonym: "interleukin-35 anabolism" EXACT [GOC:mah] synonym: "interleukin-35 biosynthesis" EXACT [GOC:mah] synonym: "interleukin-35 formation" EXACT [GOC:mah] synonym: "interleukin-35 synthesis" EXACT [GOC:mah] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0070753 ! interleukin-35 production [Term] id: GO:0070750 name: regulation of interleukin-35 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] synonym: "regulation of IL-35 biosynthesis" EXACT [GOC:mah] synonym: "regulation of IL-35 biosynthetic process" EXACT [GOC:add] synonym: "regulation of interleukin-35 anabolism" EXACT [GOC:mah] synonym: "regulation of interleukin-35 biosynthesis" EXACT [GOC:mah] synonym: "regulation of interleukin-35 formation" EXACT [GOC:mah] synonym: "regulation of interleukin-35 synthesis" EXACT [GOC:mah] is_a: GO:0042035 ! regulation of cytokine biosynthetic process is_a: GO:0070754 ! regulation of interleukin-35 production relationship: regulates GO:0070749 ! interleukin-35 biosynthetic process [Term] id: GO:0070751 name: negative regulation of interleukin-35 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] synonym: "down regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of interleukin-35 biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of IL-35 biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of IL-35 biosynthetic process" EXACT [GOC:add] synonym: "negative regulation of interleukin-35 anabolism" EXACT [GOC:mah] synonym: "negative regulation of interleukin-35 biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of interleukin-35 formation" EXACT [GOC:mah] synonym: "negative regulation of interleukin-35 synthesis" EXACT [GOC:mah] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process relationship: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process [Term] id: GO:0070752 name: positive regulation of interleukin-35 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] synonym: "activation of interleukin-35 biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of IL-35 biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of IL-35 biosynthetic process" EXACT [GOC:add] synonym: "positive regulation of interleukin-35 anabolism" EXACT [GOC:mah] synonym: "positive regulation of interleukin-35 biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of interleukin-35 formation" EXACT [GOC:mah] synonym: "positive regulation of interleukin-35 synthesis" EXACT [GOC:mah] synonym: "stimulation of interleukin-35 biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process relationship: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process [Term] id: GO:0070753 name: interleukin-35 production namespace: biological_process def: "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-35 production" EXACT [GOC:add] is_a: GO:0001816 ! cytokine production [Term] id: GO:0070754 name: regulation of interleukin-35 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-35 production." [GOC:mah] synonym: "regulation of IL-35 production" EXACT [GOC:add] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0070753 ! interleukin-35 production [Term] id: GO:0070755 name: negative regulation of interleukin-35 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production." [GOC:mah] synonym: "down regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "down-regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "downregulation of interleukin-35 production" EXACT [GOC:mah] synonym: "inhibition of interleukin-35 production" NARROW [GOC:mah] synonym: "negative regulation of IL-35 production" EXACT [GOC:add] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0070754 ! regulation of interleukin-35 production relationship: negatively_regulates GO:0070753 ! interleukin-35 production [Term] id: GO:0070756 name: positive regulation of interleukin-35 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-35 production." [GOC:mah] synonym: "activation of interleukin-35 production" NARROW [GOC:mah] synonym: "positive regulation of IL-35 production" EXACT [GOC:add] synonym: "stimulation of interleukin-35 production" NARROW [GOC:mah] synonym: "up regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "up-regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "upregulation of interleukin-35 production" EXACT [GOC:mah] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0070754 ! regulation of interleukin-35 production relationship: positively_regulates GO:0070753 ! interleukin-35 production [Term] id: GO:0070757 name: interleukin-35-mediated signaling pathway namespace: biological_process def: "A series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:add, GOC:mah] synonym: "IL-35-mediated signaling pathway" EXACT [GOC:add] synonym: "interleukin-35-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0070758 name: regulation of interleukin-35-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35-mediated binding to a cell surface receptor." [GOC:mah] synonym: "regulation of IL-35-mediated signaling pathway" EXACT [GOC:mah] synonym: "regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway relationship: regulates GO:0070757 ! interleukin-35-mediated signaling pathway [Term] id: GO:0070759 name: negative regulation of interleukin-35-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah] synonym: "negative regulation of IL-35-mediated signaling pathway" EXACT [GOC:add] synonym: "negative regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway relationship: negatively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway [Term] id: GO:0070760 name: positive regulation of interleukin-35-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah] synonym: "positive regulation of IL-35-mediated signaling pathway" EXACT [GOC:add] synonym: "positive regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway relationship: positively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway [Term] id: GO:0070761 name: pre-snoRNP complex namespace: cellular_component def: "A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes." [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390] synonym: "pre-small nucleolar ribonucleoprotein complex" EXACT [GOC:rl] is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0070762 name: NDC1 complex namespace: cellular_component def: "A protein complex that forms part of the nuclear pore complex, and contains three transmembrane nucleoporins, encoded in S. cerevisiae by Ndc1p, Pom152p and Pom34p." [GOC:mah, PMID:19414609] synonym: "NDC1 subcomplex" EXACT [PMID:19414609] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005643 ! nuclear pore [Term] id: GO:0070763 name: Delta1 complex namespace: cellular_component def: "A protein complex that consists of homodimer of the Notch ligand Delta1." [PMID:12794186] synonym: "Delta1 homodimer complex" EXACT [CORUM:3271] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070764 name: gamma-secretase-Delta1 complex namespace: cellular_component def: "A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex." [PMID:12794186] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070765 name: gamma-secretase complex namespace: cellular_component def: "A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein." [GOC:mah, PMID:15286082, PMID:15890777, PMID:17047368] synonym: "CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)" NARROW [CORUM:142] synonym: "gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)" NARROW [CORUM:130, CORUM:2891, CORUM:43, CORUM:45, CORUM:466] synonym: "gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:468] synonym: "gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)" RELATED [CORUM:3128] synonym: "gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:467] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070766 name: endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex namespace: cellular_component def: "A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof)." [PMID:8973549] synonym: "SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)" NARROW [CORUM:1876] synonym: "Stx4-Napa-Vamp3-Nsf-Vamp2 complex" NARROW [CORUM:1876] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070767 name: BRCA1-Rad51 complex namespace: cellular_component def: "A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity." [GOC:mah, PMID:9008167] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070768 name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex namespace: cellular_component def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof)." [PMID:8999968] synonym: "Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex" NARROW [CORUM:1873] synonym: "SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)" NARROW [CORUM:1873] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070769 name: alphaIIb-beta3 integrin-CIB complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin." [PMID:9030514] synonym: "ITGA2B-ITGB3-CIB1 complex" NARROW [CORUM:2379] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070770 name: alphaIIb-beta3 integrin-CD47-FAK complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK." [PMID:9169439] synonym: "ITGA2b-ITGB3-CD47-FAK complex" NARROW [CORUM:2896] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070771 name: alphaIIb-beta3 integrin-CD47-Src complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src." [PMID:9169439] synonym: "ITGA2b-ITGB3-CD47-SRC complex" NARROW [CORUM:2377] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0070772 name: PAS complex namespace: cellular_component def: "A protein complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p." [PMID:18950639, PMID:19037259, PMID:19158662] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0070773 name: protein N-terminal glutamine amidohydrolase activity namespace: molecular_function def: "Catalysis of the deamidation of an N-terminal glutamin residue of a protein." [PMID:19560421] synonym: "NtQ-amidase activity" EXACT [PMID:19560421] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0070774 name: phytoceramidase activity namespace: molecular_function def: "Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine." [GOC:pde, PMID:11356846] xref: Reactome:428211 "phytoceramidase activity" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! ceramidase activity [Term] id: GO:0070775 name: H3 histone acetyltransferase complex namespace: cellular_component def: "A multisubunit complex that catalyzes the acetylation of histone H3." [GOC:mah] synonym: "H3 HAT complex" EXACT [GOC:mah] is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0070776 name: MOZ/MORF histone acetyltransferase complex namespace: cellular_component def: "A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358] is_a: GO:0070775 ! H3 histone acetyltransferase complex [Term] id: GO:0070777 name: D-aspartate transport namespace: biological_process def: "The directed movement of D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17364, GOC:mah, GOC:rph] is_a: GO:0015810 ! aspartate transport is_a: GO:0042940 ! D-amino acid transport [Term] id: GO:0070778 name: L-aspartate transport namespace: biological_process def: "The directed movement of L-aspartate, the L-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17053, GOC:mah] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015810 ! aspartate transport [Term] id: GO:0070779 name: D-aspartate import namespace: biological_process def: "The directed movement of D-aspartate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:rph] subset: gosubset_prok synonym: "D-aspartate uptake" EXACT [GOC:mah] is_a: GO:0043090 ! amino acid import is_a: GO:0070777 ! D-aspartate transport [Term] id: GO:0070780 name: dihydrosphingosine-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate." [GOC:pde, PMID:12815058] synonym: "dihydrosphingosine-1-phosphate phosphohydrolase activity" EXACT [GOC:mah] synonym: "sphinganine-1-phosphate phosphatase activity" EXACT [GOC:mah] xref: MetaCyc:RXN3DJ-25 xref: Reactome:428665 "dihydrosphingosine-1-phosphate phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0070781 name: response to biotin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:sl] synonym: "response to Bios IIB" EXACT [GOC:sl] synonym: "response to coenzyme R" EXACT [GOC:sl] synonym: "response to vitamin B7" EXACT [GOC:sl] synonym: "response to vitamin H" EXACT [GOC:sl] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0070782 name: phosphatidylserine exposure on apoptotic cell surface namespace: biological_process def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an \"eat-me\" signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity." [GOC:mah, GOC:rk, PMID:11536005] synonym: "externalization of phosphatidylserine" EXACT [GOC:rk] is_a: GO:0017121 ! phospholipid scrambling relationship: part_of GO:0006915 ! apoptosis [Term] id: GO:0070783 name: growth of unicellular organism as a thread of attached cells namespace: biological_process def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc] subset: goslim_candida is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms [Term] id: GO:0070784 name: regulation of growth of unicellular organism as a thread of attached cells namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah] is_a: GO:0010570 ! regulation of filamentous growth relationship: regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0070785 name: negative regulation of growth of unicellular organism as a thread of attached cells namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah] is_a: GO:0060258 ! negative regulation of filamentous growth is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells relationship: negatively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0070786 name: positive regulation of growth of unicellular organism as a thread of attached cells namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah] is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells is_a: GO:0090033 ! positive regulation of filamentous growth relationship: positively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0070787 name: conidiophore development namespace: biological_process def: "The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [PMID:9529886] is_a: GO:0075259 ! spore-bearing organ development [Term] id: GO:0070788 name: conidiophore stalk development namespace: biological_process def: "The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [PMID:9529886] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0070787 ! conidiophore development [Term] id: GO:0070789 name: metula development namespace: biological_process def: "The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [PMID:9529886] synonym: "development of primary sterigmata" EXACT [PMID:9529886] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0070787 ! conidiophore development [Term] id: GO:0070790 name: phialide development namespace: biological_process def: "The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips." [PMID:9529886] synonym: "development of secondary sterigmata" EXACT [PMID:9529886] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0070787 ! conidiophore development [Term] id: GO:0070791 name: cleistothecium development namespace: biological_process def: "The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [ISBN:0471522295, PMID:17446882] is_a: GO:0000909 ! sporocarp development involved in sexual reproduction [Term] id: GO:0070792 name: Hulle cell development namespace: biological_process def: "The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [PMID:19210625] synonym: "Huelle cell development" EXACT [GOC:mah] synonym: "Hulle cell formation" NARROW [PMID:19210625] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0070791 ! cleistothecium development [Term] id: GO:0070793 name: regulation of conidiophore development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0070787 ! conidiophore development [Term] id: GO:0070794 name: negative regulation of conidiophore development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah] is_a: GO:0070793 ! regulation of conidiophore development is_a: GO:0075262 ! negative regulation of spore-bearing organ development relationship: negatively_regulates GO:0070787 ! conidiophore development [Term] id: GO:0070795 name: positive regulation of conidiophore development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah] is_a: GO:0070793 ! regulation of conidiophore development is_a: GO:0075261 ! positive regulation of spore-bearing organ development relationship: positively_regulates GO:0070787 ! conidiophore development [Term] id: GO:0070796 name: regulation of cleistothecium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah] is_a: GO:0031155 ! regulation of fruiting body development relationship: regulates GO:0070791 ! cleistothecium development [Term] id: GO:0070797 name: negative regulation of cleistothecium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah] is_a: GO:0070796 ! regulation of cleistothecium development is_a: GO:0075262 ! negative regulation of spore-bearing organ development relationship: negatively_regulates GO:0070791 ! cleistothecium development [Term] id: GO:0070798 name: positive regulation of cleistothecium development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah] is_a: GO:0070796 ! regulation of cleistothecium development is_a: GO:0075261 ! positive regulation of spore-bearing organ development relationship: positively_regulates GO:0070791 ! cleistothecium development [Term] id: GO:0070799 name: regulation of conidiophore stalk development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah] is_a: GO:0070793 ! regulation of conidiophore development relationship: regulates GO:0070788 ! conidiophore stalk development [Term] id: GO:0070800 name: negative regulation of conidiophore stalk development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0070799 ! regulation of conidiophore stalk development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0070788 ! conidiophore stalk development [Term] id: GO:0070801 name: positive regulation of conidiophore stalk development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0070799 ! regulation of conidiophore stalk development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0070788 ! conidiophore stalk development [Term] id: GO:0070802 name: regulation of metula development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah] is_a: GO:0060284 ! regulation of cell development is_a: GO:0070793 ! regulation of conidiophore development relationship: regulates GO:0070789 ! metula development [Term] id: GO:0070803 name: negative regulation of metula development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0070802 ! regulation of metula development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0070789 ! metula development [Term] id: GO:0070804 name: positive regulation of metula development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0070802 ! regulation of metula development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0070789 ! metula development [Term] id: GO:0070805 name: regulation of phialide development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah] is_a: GO:0060284 ! regulation of cell development is_a: GO:0070793 ! regulation of conidiophore development relationship: regulates GO:0070790 ! phialide development [Term] id: GO:0070806 name: negative regulation of phialide development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0070805 ! regulation of phialide development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0070790 ! phialide development [Term] id: GO:0070807 name: positive regulation of phialide development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0070805 ! regulation of phialide development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0070790 ! phialide development [Term] id: GO:0070808 name: regulation of Hulle cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah] is_a: GO:0060284 ! regulation of cell development is_a: GO:0070796 ! regulation of cleistothecium development relationship: regulates GO:0070792 ! Hulle cell development [Term] id: GO:0070809 name: negative regulation of Hulle cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0070808 ! regulation of Hulle cell development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0070792 ! Hulle cell development [Term] id: GO:0070810 name: positive regulation of Hulle cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0070808 ! regulation of Hulle cell development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0070792 ! Hulle cell development [Term] id: GO:0070811 name: glycerol-2-phosphate transport namespace: biological_process def: "The directed movement of glycerol-2-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol-2-phosphate is a phosphoric monoester of glycerol." [GOC:mah] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0070812 name: glycerol-2-phosphate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-2-phosphate(out) = ADP + phosphate + glycerol-2-phosphate(in)." [GOC:mah] subset: gosubset_prok is_a: GO:0015168 ! glycerol transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0070813 name: hydrogen sulfide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah] synonym: "hydrogen sulfide metabolism" EXACT [GOC:mah] synonym: "hydrogen sulphide metabolic process" EXACT [GOC:mah] synonym: "hydrogen sulphide metabolism" EXACT [GOC:mah] is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0070814 name: hydrogen sulfide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah] synonym: "hydrogen sulfide anabolism" EXACT [GOC:mah] synonym: "hydrogen sulfide biosynthesis" EXACT [GOC:mah] synonym: "hydrogen sulfide formation" EXACT [GOC:mah] synonym: "hydrogen sulfide synthesis" EXACT [GOC:mah] synonym: "hydrogen sulphide biosynthesis" EXACT [GOC:mah] synonym: "hydrogen sulphide biosynthetic process" EXACT [GOC:mah] is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0070813 ! hydrogen sulfide metabolic process [Term] id: GO:0070815 name: peptidyl-lysine 5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2." [PMID:19574390] synonym: "lysine hydroxylase activity" BROAD [GOC:mah] synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [GOC:mah] synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [GOC:mah] synonym: "lysyl hydroxylase activity" BROAD [GOC:mah] synonym: "peptide-lysine 5-dioxygenase activity" EXACT [GOC:mah] synonym: "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity" EXACT [EC:1.14.11.4, GOC:mah] synonym: "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.11.4, GOC:mah] synonym: "protein lysine hydroxylase activity" EXACT [GOC:mah] is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0070816 name: phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process alt_id: GO:0016245 def: "The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683] synonym: "CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:mah] synonym: "generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:krc] synonym: "generation of II(0) form of RNA polymerase II" EXACT [GOC:krc] synonym: "hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:krc] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0006468 ! protein phosphorylation [Term] id: GO:0070817 name: P-TEFb-cap methyltransferase complex localization namespace: biological_process def: "Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of P-TEFb-cap methyltransferase complex localization" EXACT [GOC:MAH] synonym: "P-TEFb-cap methyltransferase complex localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization [Term] id: GO:0070818 name: protoporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: protoporphyrinogen-IX + acceptor = protoporphyrin-IX + reduced acceptor." [EC:1.3.3.4, GOC:mah, PMID:19583219] subset: gosubset_prok synonym: "protoporphyrinogen IX oxidase activity" EXACT [EC:1.3.3.4] synonym: "protoporphyrinogen-IX oxidase activity" EXACT [EC:1.3.3.4] synonym: "protoporphyrinogenase activity" EXACT [EC:1.3.3.4] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0070819 name: menaquinone-dependent protoporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: protoporphyrinogen-IX + menaquinone = protoporphyrin-IX + reduced menaquinone." [GOC:mah, PMID:19583219] subset: gosubset_prok synonym: "protoporphyrinogen-IX:menaquinone oxidoreductase activity" EXACT [GOC:mah] is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor is_a: GO:0070818 ! protoporphyrinogen oxidase activity [Term] id: GO:0070820 name: tertiary granule namespace: cellular_component def: "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0070821 name: tertiary granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a tertiary granule." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0070820 ! tertiary granule [Term] id: GO:0070822 name: Sin3-type complex namespace: cellular_component def: "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0070823 name: HDA1 complex namespace: cellular_component def: "A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p." [GOC:dgf, GOC:mah, PMID:11287668, PMID:8663039] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0000790 ! nuclear chromatin [Term] id: GO:0070824 name: SHREC complex namespace: cellular_component def: "A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures." [GOC:mah, PMID:17289569] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0017053 ! transcriptional repressor complex [Term] id: GO:0070825 name: micropyle namespace: cellular_component def: "An external encapsulating structure part of the chorion. A single cone-shaped specialization that forms an opening in the chorion that allows sperm entry into the egg prior to fertilization." [GOC:cvs, GOC:mah, PMID:18649270] is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0042600 ! chorion [Term] id: GO:0070826 name: paraferritin complex namespace: cellular_component def: "A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme." [GOC:mah, GOC:rph, PMID:11842004, PMID:8639593] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070827 name: chromatin maintenance namespace: biological_process def: "The chromatin organization process that preserves chromatin in a stable functional or structural state." [GOC:mah] is_a: GO:0006325 ! chromatin organization is_a: GO:0071956 ! cellular component maintenance at cellular level [Term] id: GO:0070828 name: heterochromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah] is_a: GO:0006325 ! chromatin organization [Term] id: GO:0070829 name: heterochromatin maintenance namespace: biological_process def: "The chromatin organization process that preserves heterochromatin in a stable functional or structural state." [GOC:mah] is_a: GO:0070827 ! chromatin maintenance is_a: GO:0070828 ! heterochromatin organization [Term] id: GO:0070830 name: tight junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah] synonym: "tight junction formation" EXACT [GOC:mah] xref: Reactome:1253737 "Tight junction interactions" xref: Reactome:1280668 "Tight junction interactions" xref: Reactome:1299494 "Tight junction interactions" xref: Reactome:1327254 "Tight junction interactions" xref: Reactome:1353349 "Tight junction interactions" xref: Reactome:1373522 "Tight junction interactions" xref: Reactome:1393543 "Tight junction interactions" xref: Reactome:1418042 "Tight junction interactions" xref: Reactome:1451135 "Tight junction interactions" xref: Reactome:420029 "Tight junction interactions" is_a: GO:0007043 ! cell-cell junction assembly relationship: part_of GO:0043297 ! apical junction assembly [Term] id: GO:0070831 name: basement membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah] comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer. is_a: GO:0071711 ! basement membrane organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0070832 name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-2] xref: MetaCyc:PWY4FS-2 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process [Term] id: GO:0070833 name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-3] xref: MetaCyc:PWY4FS-3 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process [Term] id: GO:0070834 name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-4] xref: MetaCyc:PWY4FS-4 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process [Term] id: GO:0070835 name: chromium ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of chromium (Cr) ions from one side of a membrane to the other." [GOC:mah] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0070836 name: caveola assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane." [GOC:BHF, GOC:mah, GOC:vk, PMID:12633858] synonym: "caveola formation" EXACT [GOC:mah] synonym: "caveolar biogenesis" RELATED [PMID:12633858] is_a: GO:0001765 ! membrane raft assembly [Term] id: GO:0070837 name: dehydroascorbic acid transport namespace: biological_process def: "The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C." [GOC:sl] synonym: "dehydroascorbate transport" EXACT [GOC:sl] is_a: GO:0051180 ! vitamin transport [Term] id: GO:0070838 name: divalent metal ion transport namespace: biological_process def: "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] subset: gosubset_prok is_a: GO:0030001 ! metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport [Term] id: GO:0070839 name: divalent metal ion export namespace: biological_process def: "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, out of a cell or organelle." [GOC:mah] is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0070840 name: dynein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:BHF, GOC:mah] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0070841 name: inclusion body assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah] is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0070842 name: aggresome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein." [GOC:BHF, GOC:rl, PMID:14675537] is_a: GO:0070841 ! inclusion body assembly [Term] id: GO:0070843 name: misfolded protein transport namespace: biological_process def: "The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537] is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0070844 name: polyubiquitinated protein transport namespace: biological_process def: "The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537] synonym: "polyubiquitylated protein transport" EXACT [GOC:mah] is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0070845 name: polyubiquitinated misfolded protein transport namespace: biological_process def: "The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537] synonym: "misfolded polyubiquitinated protein transport" RELATED [GOC:mah] synonym: "polyubiquitylated misfolded protein transport" EXACT [GOC:mah] is_a: GO:0070843 ! misfolded protein transport is_a: GO:0070844 ! polyubiquitinated protein transport [Term] id: GO:0070846 name: Hsp90 deacetylation namespace: biological_process def: "The modification of an Hsp90 protein by removal of acetyl groups." [GOC:BHF, GOC:mah] is_a: GO:0006476 ! protein deacetylation [Term] id: GO:0070847 name: core mediator complex namespace: cellular_component def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] synonym: "C mediator complex" EXACT [PMID:17870225] synonym: "S mediator complex" EXACT [PMID:17043218] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0070848 name: response to growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0070849 name: response to epidermal growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:BHF, GOC:mah] synonym: "response to EGF stimulus" EXACT [GOC:mah] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor stimulus [Term] id: GO:0070850 name: TACC/TOG complex namespace: cellular_component def: "A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase." [GOC:mah, GOC:vw, PMID:19606211] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0070851 name: growth factor receptor binding namespace: molecular_function def: "Interacting selectively with a growth factor receptor." [GOC:mah] is_a: GO:0005102 ! receptor binding [Term] id: GO:0070852 name: cell body fiber namespace: cellular_component def: "A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches." [GOC:dos, GOC:mah] synonym: "cell body fibre" EXACT [] synonym: "primary neurite" RELATED [GOC:dos, GOC:mah] is_a: GO:0043005 ! neuron projection [Term] id: GO:0070853 name: myosin VI binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:15473855] is_a: GO:0017022 ! myosin binding [Term] id: GO:0070854 name: myosin VI heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin VI complex." [GOC:sart] is_a: GO:0032036 ! myosin heavy chain binding is_a: GO:0070853 ! myosin VI binding [Term] id: GO:0070855 name: myosin VI head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin VI heavy chain." [GOC:sart] is_a: GO:0032028 ! myosin head/neck binding is_a: GO:0070854 ! myosin VI heavy chain binding [Term] id: GO:0070856 name: myosin VI light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin VI complex." [GOC:sart] is_a: GO:0032027 ! myosin light chain binding is_a: GO:0070853 ! myosin VI binding [Term] id: GO:0070857 name: regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "regulation of bile acid formation" EXACT [GOC:mah] synonym: "regulation of bile acid synthesis" EXACT [GOC:mah] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process relationship: regulates GO:0006699 ! bile acid biosynthetic process [Term] id: GO:0070858 name: negative regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of bile acid formation" EXACT [GOC:mah] synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0070857 ! regulation of bile acid biosynthetic process relationship: negatively_regulates GO:0006699 ! bile acid biosynthetic process [Term] id: GO:0070859 name: positive regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of bile acid formation" EXACT [GOC:mah] synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah] synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0070857 ! regulation of bile acid biosynthetic process relationship: positively_regulates GO:0006699 ! bile acid biosynthetic process [Term] id: GO:0070860 name: RNA polymerase I core factor complex namespace: cellular_component def: "A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872] comment: Note that, although this complex can be considered analogous to the mammalian transcription factor SL complex, the core factor complex does not include TBP, whereas SL1 does. is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0070861 name: regulation of protein exit from endoplasmic reticulum namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah] synonym: "regulation of protein exit from ER" EXACT [GOC:mah] synonym: "regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah] synonym: "regulation of protein export from ER" EXACT [GOC:mah] is_a: GO:0033157 ! regulation of intracellular protein transport relationship: regulates GO:0032527 ! protein exit from endoplasmic reticulum [Term] id: GO:0070862 name: negative regulation of protein exit from endoplasmic reticulum namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah] synonym: "down regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "down-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "downregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "inhibition of protein exit from endoplasmic reticulum" NARROW [GOC:mah] synonym: "negative regulation of protein exit from ER" EXACT [GOC:mah] synonym: "negative regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah] synonym: "negative regulation of protein export from ER" EXACT [GOC:mah] is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum is_a: GO:0090317 ! negative regulation of intracellular protein transport relationship: negatively_regulates GO:0032527 ! protein exit from endoplasmic reticulum [Term] id: GO:0070863 name: positive regulation of protein exit from endoplasmic reticulum namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah] synonym: "activation of protein exit from endoplasmic reticulum" NARROW [GOC:mah] synonym: "positive regulation of protein exit from ER" EXACT [GOC:mah] synonym: "positive regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah] synonym: "positive regulation of protein export from ER" EXACT [GOC:mah] synonym: "stimulation of protein exit from endoplasmic reticulum" NARROW [GOC:mah] synonym: "up regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "up-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "upregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum is_a: GO:0090316 ! positive regulation of intracellular protein transport relationship: positively_regulates GO:0032527 ! protein exit from endoplasmic reticulum [Term] id: GO:0070864 name: sperm individualization complex namespace: cellular_component def: "A macromolecular complex that cytoskeletal components and part of the cell membrane, forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716] is_a: GO:0032991 ! macromolecular complex is_a: GO:0044464 ! cell part [Term] id: GO:0070865 name: investment cone namespace: cellular_component def: "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716] synonym: "F-actin cone" EXACT [PMID:15829565] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0070864 ! sperm individualization complex [Term] id: GO:0070866 name: sterol-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) in the presence of sterols." [GOC:ecd] is_a: GO:0005515 ! protein binding [Term] id: GO:0070867 name: mating projection tip membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a mating projection tip." [GOC:mah] is_a: GO:0044459 ! plasma membrane part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0043332 ! mating projection tip [Term] id: GO:0070868 name: heterochromatin organization involved in chromatin silencing namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah] is_a: GO:0070828 ! heterochromatin organization relationship: part_of GO:0006342 ! chromatin silencing [Term] id: GO:0070869 name: heterochromatin formation involved in chromatin silencing namespace: biological_process def: "Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing." [GOC:mah] is_a: GO:0031507 ! heterochromatin formation is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing [Term] id: GO:0070870 name: heterochromatin maintenance involved in chromatin silencing namespace: biological_process def: "A chromatin organization process that preserves heterochromatin in a stable functional or structural state, and that contributes to chromatin silencing." [GOC:mah] is_a: GO:0070829 ! heterochromatin maintenance is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing [Term] id: GO:0070871 name: cell wall organization involved in conjugation with cellular fusion namespace: biological_process def: "A process of cell wall organization that contributes to conjugation with cellular fusion." [GOC:mah] is_a: GO:0007047 ! cellular cell wall organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0070872 name: plasma membrane organization involved in conjugation with cellular fusion namespace: biological_process def: "A process of plasma membrane organization that contributes to conjugation with cellular fusion." [GOC:mah] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0070873 name: regulation of glycogen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy relationship: regulates GO:0005977 ! glycogen metabolic process [Term] id: GO:0070874 name: negative regulation of glycogen metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "negative regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process relationship: negatively_regulates GO:0005977 ! glycogen metabolic process [Term] id: GO:0070875 name: positive regulation of glycogen metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "positive regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010907 ! positive regulation of glucose metabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process relationship: positively_regulates GO:0005977 ! glycogen metabolic process [Term] id: GO:0070876 name: SOSS complex namespace: cellular_component def: "A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80." [PMID:19683501] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070877 name: microprocessor complex namespace: cellular_component def: "A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0070878 name: pri-miRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding." [PMID:15531877, PMID:15574589] synonym: "primary microRNA binding" EXACT [PMID:15531877, PMID:15574589] is_a: GO:0003723 ! RNA binding [Term] id: GO:0070879 name: fungal-type cell wall beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah, GOC:vw] synonym: "fungal-type cell wall beta-glucan metabolism" EXACT [GOC:mah] is_a: GO:0034406 ! cell wall beta-glucan metabolic process is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis [Term] id: GO:0070880 name: fungal-type cell wall beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah] synonym: "fungal-type cell wall beta-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-glucan synthesis" EXACT [GOC:mah] is_a: GO:0051274 ! beta-glucan biosynthetic process is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process [Term] id: GO:0070881 name: regulation of proline transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proline transport." [GOC:mah] is_a: GO:0051955 ! regulation of amino acid transport relationship: regulates GO:0015824 ! proline transport [Term] id: GO:0070882 name: cellular cell wall organization or biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] subset: goslim_pombe subset: gosubset_prok synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah] is_a: GO:0071554 ! cell wall organization or biogenesis is_a: GO:0071841 ! cellular component organization or biogenesis at cellular level [Term] id: GO:0070883 name: pre-miRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094] synonym: "precursor microRNA binding" EXACT [PMID:18951094] is_a: GO:0003723 ! RNA binding [Term] id: GO:0070884 name: regulation of calcineurin-NFAT signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway." [GOC:ai] synonym: "regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah] is_a: GO:0050848 ! regulation of calcium-mediated signaling relationship: regulates GO:0033173 ! calcineurin-NFAT signaling pathway [Term] id: GO:0070885 name: negative regulation of calcineurin-NFAT signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway." [GOC:mah] synonym: "down regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] synonym: "down-regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] synonym: "downregulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] synonym: "inhibition of calcineurin-NFAT signaling pathway" NARROW [GOC:mah] synonym: "negative regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah] is_a: GO:0050849 ! negative regulation of calcium-mediated signaling is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling pathway relationship: negatively_regulates GO:0033173 ! calcineurin-NFAT signaling pathway [Term] id: GO:0070886 name: positive regulation of calcineurin-NFAT signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway." [GOC:mah] synonym: "activation of calcineurin-NFAT signaling pathway" NARROW [GOC:mah] synonym: "positive regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah] synonym: "stimulation of calcineurin-NFAT signaling pathway" NARROW [GOC:mah] synonym: "up regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] synonym: "up-regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] synonym: "upregulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] is_a: GO:0050850 ! positive regulation of calcium-mediated signaling is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling pathway relationship: positively_regulates GO:0033173 ! calcineurin-NFAT signaling pathway [Term] id: GO:0070887 name: cellular response to chemical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] is_a: GO:0042221 ! response to chemical stimulus is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0070888 name: E-box binding namespace: molecular_function def: "Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "E-box promoter binding" EXACT [GOC:vk] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0070889 name: platelet alpha granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets." [GOC:rph, PMID:16123220] synonym: "platelet alpha granule organization and biogenesis" RELATED [GOC:mah] synonym: "platelet alpha-granule organization" EXACT [GOC:mah] is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0070890 name: sodium-dependent L-ascorbate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)." [GOC:mah, PMID:18094143] is_a: GO:0015229 ! L-ascorbic acid transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0070891 name: lipoteichoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoteichoic acid." [GOC:add, PMID:14665680] is_a: GO:0005488 ! binding [Term] id: GO:0070892 name: lipoteichoic acid receptor activity namespace: molecular_function def: "Combining with lipoteichoic acid to initiate a change in cell activity." [GOC:add, PMID:14665680] is_a: GO:0008329 ! pattern recognition receptor activity is_a: GO:0070891 ! lipoteichoic acid binding [Term] id: GO:0070893 name: transposon integration namespace: biological_process def: "Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome." [GOC:jp, PMID:10882723] is_a: GO:0015074 ! DNA integration is_a: GO:0032196 ! transposition [Term] id: GO:0070894 name: regulation of transposon integration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah] is_a: GO:0010528 ! regulation of transposition is_a: GO:0051052 ! regulation of DNA metabolic process relationship: regulates GO:0070893 ! transposon integration [Term] id: GO:0070895 name: negative regulation of transposon integration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah] synonym: "down regulation of transposon integration" EXACT [GOC:mah] synonym: "down-regulation of transposon integration" EXACT [GOC:mah] synonym: "downregulation of transposon integration" EXACT [GOC:mah] synonym: "inhibition of transposon integration" NARROW [GOC:mah] is_a: GO:0010529 ! negative regulation of transposition is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:0070894 ! regulation of transposon integration relationship: negatively_regulates GO:0070893 ! transposon integration [Term] id: GO:0070896 name: positive regulation of transposon integration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah] synonym: "activation of transposon integration" NARROW [GOC:mah] synonym: "stimulation of transposon integration" NARROW [GOC:mah] synonym: "up regulation of transposon integration" EXACT [GOC:mah] synonym: "up-regulation of transposon integration" EXACT [GOC:mah] synonym: "upregulation of transposon integration" EXACT [GOC:mah] is_a: GO:0010530 ! positive regulation of transposition is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:0070894 ! regulation of transposon integration relationship: positively_regulates GO:0070893 ! transposon integration [Term] id: GO:0070897 name: DNA-dependent transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:jp, GOC:txnOH] synonym: "transcription PIC biosynthesis" BROAD [GOC:mah] synonym: "transcription PIC formation" BROAD [GOC:mah] synonym: "transcriptional preinitiation complex formation" BROAD [GOC:mah] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006352 ! transcription initiation, DNA-dependent [Term] id: GO:0070898 name: RNA polymerase III transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter." [GOC:jp, PMID:11387215] synonym: "RNA polymerase III transcription PIC biosynthesis" EXACT [GOC:mah] synonym: "RNA polymerase III transcription PIC formation" EXACT [GOC:mah] synonym: "RNA polymerase III transcriptional preinitiation complex formation" EXACT [GOC:mah] is_a: GO:0070897 ! DNA-dependent transcriptional preinitiation complex assembly relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter [Term] id: GO:0070899 name: mitochondrial tRNA wobble uridine modification namespace: biological_process def: "The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified." [GOC:mah, GOC:mcc] is_a: GO:0002098 ! tRNA wobble uridine modification is_a: GO:0070900 ! mitochondrial tRNA modification [Term] id: GO:0070900 name: mitochondrial tRNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically." [GOC:mah, GOC:mcc] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0006400 ! tRNA modification is_a: GO:0070525 ! threonylcarbamoyladenosine metabolic process [Term] id: GO:0070901 name: mitochondrial tRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc] is_a: GO:0030488 ! tRNA methylation is_a: GO:0070900 ! mitochondrial tRNA modification [Term] id: GO:0070902 name: mitochondrial tRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc] is_a: GO:0031119 ! tRNA pseudouridine synthesis is_a: GO:0070900 ! mitochondrial tRNA modification [Term] id: GO:0070903 name: mitochondrial tRNA thio-modification namespace: biological_process def: "The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc] is_a: GO:0034227 ! tRNA thio-modification is_a: GO:0070900 ! mitochondrial tRNA modification [Term] id: GO:0070904 name: transepithelial L-ascorbic acid transport namespace: biological_process def: "The directed movement of L-ascorbic acid from one side of an epithelium to the other." [GOC:mah, GOC:yaf] synonym: "transepithelial L-ascorbate transport" EXACT [GOC:mah] synonym: "transepithelial vitamin C transport" EXACT [GOC:mah] is_a: GO:0015882 ! L-ascorbic acid transport is_a: GO:0070633 ! transepithelial transport [Term] id: GO:0070905 name: serine binding namespace: molecular_function def: "Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid." [CHEBI:17822, GOC:rph] synonym: "Ser binding" EXACT [GOC:mah] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0070906 name: aspartate:alanine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out)." [GOC:dh] synonym: "aspartate-alanine antiporter activity" EXACT [GOC:mah] synonym: "aspartate/alanine antiporter activity" EXACT [GOC:mah] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0070907 name: histidine:histamine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)." [GOC:dh] synonym: "histidine-histamine antiporter activity" EXACT [GOC:mah] synonym: "histidine/histamine antiporter activity" EXACT [GOC:mah] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0070908 name: tyrosine:tyramine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh] synonym: "tyrosine-tyramine antiporter activity" EXACT [GOC:mah] synonym: "tyrosine/tyramine antiporter activity" EXACT [GOC:mah] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0070909 name: glutamate:gamma-aminobutyric acid antiporter activity namespace: molecular_function def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh] synonym: "glutamate-gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah] synonym: "glutamate/gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah] synonym: "glutamate: GABA antiporter activity" EXACT [GOC:dh] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0070910 name: cell wall macromolecule catabolic process involved in cell wall disassembly namespace: biological_process def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall." [GOC:mah] is_a: GO:0016998 ! cell wall macromolecule catabolic process relationship: part_of GO:0060871 ! cellular cell wall disassembly [Term] id: GO:0070911 name: global genome nucleotide-excision repair namespace: biological_process def: "The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome." [PMID:10197977, PMID:18794354] subset: gosubset_prok synonym: "GG-NER" EXACT [PMID:10197977] synonym: "GGR" EXACT [GOC:vw, PMID:18794354] synonym: "global genome NER" EXACT [GOC:mah] synonym: "global genomic nucleotide-excision repair" EXACT [GOC:mah, GOC:vw] synonym: "global genomic repair" EXACT [GOC:vw, PMID:18794354] is_a: GO:0006289 ! nucleotide-excision repair [Term] id: GO:0070912 name: Ddb1-Ckn1 complex namespace: cellular_component def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0070913 name: Ddb1-Wdr21 complex namespace: cellular_component def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0070914 name: UV-damage excision repair namespace: biological_process def: "A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100] synonym: "UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:vw] synonym: "UVDE-dependent excision repair" EXACT [GOC:vw, PMID:9619100] synonym: "UVER" EXACT [GOC:vw, PMID:9619100] is_a: GO:0006281 ! DNA repair [Term] id: GO:0070915 name: lysophosphatidic acid receptor activity namespace: molecular_function def: "Combining with lysophosphatidic acid to initiate a change in cell activity." [GOC:mah] is_a: GO:0045125 ! bioactive lipid receptor activity [Term] id: GO:0070916 name: inositol phosphoceramide synthase complex namespace: cellular_component def: "A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces)." [GOC:mah, PMID:19726565] synonym: "IPC synthase complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0070917 name: inositol phosphoceramide synthase regulator activity namespace: molecular_function def: "Modulates the activity of inositol phosphoceramide synthase." [GOC:mah] comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "IPC synthase regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0070918 name: production of small RNA involved in gene silencing by RNA namespace: biological_process def: "The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease." [GOC:mah, PMID:19239886] synonym: "gene silencing by RNA, production of guide RNA" EXACT [GOC:mah] synonym: "gene silencing by RNA, production of small RNA" EXACT [GOC:mah] is_a: GO:0031050 ! dsRNA fragmentation relationship: part_of GO:0031047 ! gene silencing by RNA [Term] id: GO:0070919 name: production of siRNA involved in chromatin silencing by small RNA namespace: biological_process def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA." [GOC:mah, PMID:19239886] synonym: "chromatin silencing by small RNA, production of guide RNAs" EXACT [] synonym: "chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah] synonym: "production of guide RNAs involved in chromatin silencing by small RNA" EXACT [GOC:mah] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0031048 ! chromatin silencing by small RNA [Term] id: GO:0070920 name: regulation of production of small RNA involved in gene silencing by RNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the production of small RNA involved in gene silencing by RNA." [GOC:mah] synonym: "regulation of gene silencing by RNA, production of guide RNA" EXACT [GOC:mah] synonym: "regulation of gene silencing by RNA, production of small RNA" EXACT [GOC:mah] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0051252 ! regulation of RNA metabolic process is_a: GO:0060966 ! regulation of gene silencing by RNA relationship: regulates GO:0070918 ! production of small RNA involved in gene silencing by RNA [Term] id: GO:0070921 name: regulation of production of siRNA involved in chromatin silencing by small RNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA." [GOC:mah] synonym: "regulation of chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah] is_a: GO:0010964 ! regulation of chromatin silencing by small RNA is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA relationship: regulates GO:0070919 ! production of siRNA involved in chromatin silencing by small RNA [Term] id: GO:0070922 name: small RNA loading onto RISC namespace: biological_process def: "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA." [GOC:mah, PMID:19239886] synonym: "gene silencing by RNA, small RNA loading onto RISC" EXACT [GOC:mah] synonym: "RISC assembly" RELATED [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0031047 ! gene silencing by RNA [Term] id: GO:0070923 name: siRNA loading onto RISC involved in chromatin silencing by small RNA namespace: biological_process def: "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of chromatin silencing by small RNA." [GOC:mah, PMID:19239886] synonym: "chromatin silencing by small RNA, siRNA loading onto RISC" EXACT [GOC:mah] is_a: GO:0070922 ! small RNA loading onto RISC relationship: part_of GO:0031048 ! chromatin silencing by small RNA [Term] id: GO:0070924 name: heterochromatin formation involved in chromatin silencing by small RNA namespace: biological_process def: "The process in which an siRNA-associated RNA-induced silencing complex (siRISC) associates with nascent transcripts and RNA polymerase to induce the formation of heterochromatin." [GOC:mah, PMID:19239886] synonym: "chromatin silencing by small RNA, heterochromatin formation" EXACT [GOC:mah] synonym: "small RNA-mediated heterochromatin biosynthesis" EXACT [GOC:mah] synonym: "small RNA-mediated heterochromatin formation" EXACT [GOC:mah] is_a: GO:0070869 ! heterochromatin formation involved in chromatin silencing relationship: part_of GO:0031048 ! chromatin silencing by small RNA [Term] id: GO:0070925 name: organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0006996 ! organelle organization [Term] id: GO:0070926 name: regulation of ATP:ADP antiporter activity namespace: biological_process def: "Any process that modulates the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah] is_a: GO:0022898 ! regulation of transmembrane transporter activity [Term] id: GO:0070927 name: negative regulation of ATP:ADP antiporter activity namespace: biological_process def: "Any process that stops or reduces the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah] synonym: "down regulation of ATP:ADP antiporter activity" EXACT [GOC:mah] synonym: "down-regulation of ATP:ADP antiporter activity" EXACT [GOC:mah] synonym: "downregulation of ATP:ADP antiporter activity" EXACT [GOC:mah] synonym: "inhibition of ATP:ADP antiporter activity" NARROW [GOC:mah] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0070926 ! regulation of ATP:ADP antiporter activity [Term] id: GO:0070928 name: regulation of mRNA stability, ncRNA-mediated namespace: biological_process def: "Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jh2] synonym: "ncRNA-mediated regulation of mRNA stability" EXACT [GOC:mah] synonym: "regulation of mRNA stability, non-coding RNA-mediated" EXACT [GOC:mah] is_a: GO:0043488 ! regulation of mRNA stability [Term] id: GO:0070929 name: trans-translation namespace: biological_process def: "A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes." [GOC:jh2, GOC:mah] is_a: GO:0006414 ! translational elongation [Term] id: GO:0070930 name: co-translational protein tagging namespace: biological_process def: "A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation." [GOC:jh2, GOC:mah] comment: Note that this term is not a child of 'co-translational protein modification process ; GO:0043686' because co-translational protein modification implies modification of a previously incorporated amino acid in a nascent chain, rather than addition of new sequence to the C-terminus. synonym: "cotranslational protein tagging" EXACT [GOC:mah] synonym: "protein modification by trans-translation" EXACT [GOC:mah] is_a: GO:0006464 ! protein modification process [Term] id: GO:0070931 name: Golgi-associated vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a Golgi-associated vesicle." [GOC:mah] is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0005798 ! Golgi-associated vesicle [Term] id: GO:0070932 name: histone H3 deacetylation namespace: biological_process def: "The modification of histone H3 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl] is_a: GO:0016575 ! histone deacetylation [Term] id: GO:0070933 name: histone H4 deacetylation namespace: biological_process def: "The modification of histone H4 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl] is_a: GO:0016575 ! histone deacetylation [Term] id: GO:0070934 name: CRD-mediated mRNA stabilization namespace: biological_process def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] synonym: "coding region determinant-mediated mRNA stabilization" EXACT [GOC:mah] is_a: GO:0048255 ! mRNA stabilization [Term] id: GO:0070935 name: 3'-UTR-mediated mRNA stabilization namespace: biological_process def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303] synonym: "3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:mah] is_a: GO:0048255 ! mRNA stabilization [Term] id: GO:0070936 name: protein K48-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404] synonym: "protein K48-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination [Term] id: GO:0070937 name: CRD-mediated mRNA stability complex namespace: cellular_component def: "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, IGF2BP1 and at least four additional proteins: HNRNPU, SYNCRIP, YBX1, and DHX9." [GOC:mah, PMID:19029303] comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070938 name: contractile ring namespace: cellular_component def: "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889] synonym: "constriction ring" RELATED [GOC:mah] synonym: "cytokinetic ring" RELATED [GOC:mah] is_a: GO:0044464 ! cell part [Term] id: GO:0070939 name: Dsl1p complex namespace: cellular_component def: "A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p." [GOC:jh, GOC:mah, PMID:19151722] comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070940 name: dephosphorylation of RNA polymerase II C-terminal domain namespace: biological_process def: "The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683] synonym: "CTD domain dephosphorylation of RNA polymerase II" EXACT [GOC:mah] synonym: "generation of hypophosphorylated CTD of RNA polymerase II" EXACT [GOC:krc] synonym: "generation of II(A) form of RNA polymerase II" EXACT [GOC:krc] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0006470 ! protein dephosphorylation [Term] id: GO:0070941 name: eisosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an eisosome, a large immobile protein complex that forms at the plasma membrane and marks endocytic sites." [GOC:jp, PMID:19564405] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0070942 name: neutrophil mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a neutrophil." [GOC:add, ISBN:0781765196] synonym: "neutrophil mediated cell killing" EXACT [GOC:add] is_a: GO:0001909 ! leukocyte mediated cytotoxicity relationship: part_of GO:0002446 ! neutrophil mediated immunity [Term] id: GO:0070943 name: neutrophil mediated killing of symbiont cell namespace: biological_process def: "The directed killing of a symbiont target cell by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0051873 ! killing by host of symbiont cells is_a: GO:0070942 ! neutrophil mediated cytotoxicity [Term] id: GO:0070944 name: neutrophil mediated killing of bacterium namespace: biological_process def: "The directed killing of a bacterium by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0070943 ! neutrophil mediated killing of symbiont cell relationship: part_of GO:0042742 ! defense response to bacterium [Term] id: GO:0070945 name: neutrophil mediated killing of gram-negative bacterium namespace: biological_process def: "The directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0070944 ! neutrophil mediated killing of bacterium relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium [Term] id: GO:0070946 name: neutrophil mediated killing of gram-positive bacterium namespace: biological_process def: "The directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0070944 ! neutrophil mediated killing of bacterium relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium [Term] id: GO:0070947 name: neutrophil mediated killing of fungus namespace: biological_process def: "The directed killing of a fungal cell by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0070943 ! neutrophil mediated killing of symbiont cell relationship: part_of GO:0050832 ! defense response to fungus [Term] id: GO:0070948 name: regulation of neutrophil mediated cytotoxicity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "regulation of neutrophil mediated cell killing" EXACT [GOC:add] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity relationship: regulates GO:0070942 ! neutrophil mediated cytotoxicity [Term] id: GO:0070949 name: regulation of neutrophil mediated killing of symbiont cell namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0051709 ! regulation of killing of cells of other organism is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity relationship: regulates GO:0070943 ! neutrophil mediated killing of symbiont cell [Term] id: GO:0070950 name: regulation of neutrophil mediated killing of bacterium namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell relationship: regulates GO:0070944 ! neutrophil mediated killing of bacterium [Term] id: GO:0070951 name: regulation of neutrophil mediated killing of gram-negative bacterium namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium relationship: regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium [Term] id: GO:0070952 name: regulation of neutrophil mediated killing of gram-positive bacterium namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-positive bacterium, the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium relationship: regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium [Term] id: GO:0070953 name: regulation of neutrophil mediated killing of fungus namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell relationship: regulates GO:0070947 ! neutrophil mediated killing of fungus [Term] id: GO:0070954 name: negative regulation of neutrophil mediated cytotoxicity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated cytotoxicity" NARROW [GOC:mah] synonym: "negative regulation of neutrophil mediated cell killing" EXACT [GOC:add] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity relationship: negatively_regulates GO:0070942 ! neutrophil mediated cytotoxicity [Term] id: GO:0070955 name: negative regulation of neutrophil mediated killing of symbiont cell namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah] is_a: GO:0051711 ! negative regulation of killing of cells of other organism is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell is_a: GO:0070954 ! negative regulation of neutrophil mediated cytotoxicity relationship: negatively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell [Term] id: GO:0070956 name: negative regulation of neutrophil mediated killing of bacterium namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of bacterium" NARROW [GOC:mah] is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell relationship: negatively_regulates GO:0070944 ! neutrophil mediated killing of bacterium [Term] id: GO:0070957 name: negative regulation of neutrophil mediated killing of gram-negative bacterium namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah] is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium relationship: negatively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium [Term] id: GO:0070958 name: negative regulation of neutrophil mediated killing of gram-positive bacterium namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah] is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium relationship: negatively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium [Term] id: GO:0070959 name: negative regulation of neutrophil mediated killing of fungus namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of fungus" NARROW [GOC:mah] is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell relationship: negatively_regulates GO:0070947 ! neutrophil mediated killing of fungus [Term] id: GO:0070960 name: positive regulation of neutrophil mediated cytotoxicity namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated cytotoxicity" NARROW [GOC:mah] synonym: "positive regulation of neutrophil mediated cell killing" EXACT [GOC:add] synonym: "stimulation of neutrophil mediated cytotoxicity" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity relationship: positively_regulates GO:0070942 ! neutrophil mediated cytotoxicity [Term] id: GO:0070961 name: positive regulation of neutrophil mediated killing of symbiont cell namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] is_a: GO:0051712 ! positive regulation of killing of cells of other organism is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell is_a: GO:0070960 ! positive regulation of neutrophil mediated cytotoxicity relationship: positively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell [Term] id: GO:0070962 name: positive regulation of neutrophil mediated killing of bacterium namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of bacterium" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of bacterium" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell relationship: positively_regulates GO:0070944 ! neutrophil mediated killing of bacterium [Term] id: GO:0070963 name: positive regulation of neutrophil mediated killing of gram-negative bacterium namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium relationship: positively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium [Term] id: GO:0070964 name: positive regulation of neutrophil mediated killing of gram-positive bacterium namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium relationship: positively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium [Term] id: GO:0070965 name: positive regulation of neutrophil mediated killing of fungus namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of fungus" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of fungus" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell relationship: positively_regulates GO:0070947 ! neutrophil mediated killing of fungus [Term] id: GO:0070966 name: nuclear-transcribed mRNA catabolic process, no-go decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation." [GOC:jp, PMID:16554824] synonym: "no-go decay" EXACT [GOC:jp] synonym: "no-go mRNA decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA breakdown, no-go decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA catabolism, no-go decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA degradation, no-go decay" EXACT [GOC:jp] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0070967 name: coenzyme F420 binding namespace: molecular_function def: "Interacting selectively and non-covalently with F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:16848, GOC:dh] is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0070968 name: pyrroloquinoline quinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases." [CHEBI:18315, GOC:dh] synonym: "PQQ binding" EXACT [GOC:dh] is_a: GO:0048038 ! quinone binding [Term] id: GO:0070969 name: ULK1-ATG13-FIP200 complex namespace: cellular_component def: "A protein complex that is essential for mammalian autophagy, and consists of at least 3 proteins: ULK1, ATG13 and RB1CC1(FIP200). This complex is the mammalian counterpart of Atg1-Atg13-Atg17 in yeast." [PMID:19211835, PMID:19258318, PMID:19597335] synonym: "ULK1-ATG13-RB1CC1 complex" EXACT [GOC:curators] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070970 name: interleukin-2 secretion namespace: biological_process def: "The regulated release of interleukin-2 from a cell or group of cells." [GOC:mah, PMID:16930574] synonym: "IL-2 secretion" EXACT [GOC:mah] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032623 ! interleukin-2 production [Term] id: GO:0070971 name: endoplasmic reticulum exit site namespace: cellular_component def: "An endoplasmic reticulum part at which COPII-coated vesicles are produced." [PMID:15623529, PMID:16957052] synonym: "ER exit site" EXACT [GOC:mah] synonym: "transitional ER" EXACT [PMID:15623529] is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0070972 name: protein localization in endoplasmic reticulum namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah] synonym: "protein localisation in endoplasmic reticulum" EXACT [GOC:mah] synonym: "protein localization in ER" EXACT [GOC:mah] synonym: "protein localization to endoplasmic reticulum" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0070973 name: protein localization to endoplasmic reticulum exit site namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah] synonym: "protein localisation to endoplasmic reticulum exit site" EXACT [GOC:mah] synonym: "protein localization to ER exit site" EXACT [GOC:mah] is_a: GO:0070972 ! protein localization in endoplasmic reticulum [Term] id: GO:0070974 name: POU domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors." [GOC:mah, GOC:yaf, InterPro:IPR000327] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070975 name: FHA domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich." [GOC:mah, InterPro:IPR000253] synonym: "Forkhead-associated domain binding" EXACT [InterPro:IPR000253] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070976 name: TIR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157] synonym: "Toll-Interleukin receptor domain binding" EXACT [InterPro:IPR000157] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070977 name: bone maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0060348 ! bone development [Term] id: GO:0070978 name: voltage-gated calcium channel complex assembly namespace: biological_process def: "Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex." [GOC:mh] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0070979 name: protein K11-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135] is_a: GO:0000209 ! protein polyubiquitination [Term] id: GO:0070980 name: biphenyl catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [CHEBI:17097, PMID:16310831, PMID:16339959, UniPathway:UPA00155] synonym: "biphenyl breakdown" EXACT [GOC:mah] synonym: "biphenyl catabolism" EXACT [GOC:mah] synonym: "biphenyl degradation" EXACT [GOC:mah] is_a: GO:0018879 ! biphenyl metabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0070981 name: L-asparagine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [CHEBI:17196, GOC:mah] subset: gosubset_prok synonym: "L-asparagine anabolism" EXACT [GOC:mah] synonym: "L-asparagine biosynthesis" EXACT [GOC:mah] synonym: "L-asparagine formation" EXACT [GOC:mah] synonym: "L-asparagine synthesis" EXACT [GOC:mah] is_a: GO:0006529 ! asparagine biosynthetic process is_a: GO:0070982 ! L-asparagine metabolic process [Term] id: GO:0070982 name: L-asparagine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [CHEBI:17196, GOC:mah] subset: gosubset_prok synonym: "L-asparagine metabolism" EXACT [GOC:mah] is_a: GO:0006528 ! asparagine metabolic process [Term] id: GO:0070983 name: dendrite guidance namespace: biological_process def: "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] synonym: "dendritic guidance" EXACT [GOC:sart] is_a: GO:0006928 ! cellular component movement relationship: part_of GO:0048813 ! dendrite morphogenesis [Term] id: GO:0070984 name: SET domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation." [GOC:sart, Pfam:PF00856, PMID:12575990] synonym: "SET binding" EXACT [GOC:sart] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070985 name: TFIIK complex namespace: cellular_component def: "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces, TFIIK contains Ccl1p, Tfb3p and Kin2p." [GOC:mah, PMID:19818408] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0005675 ! holo TFIIH complex [Term] id: GO:0070986 name: left/right axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes)." [GOC:dph, GOC:gvg, GOC:mah] synonym: "left-right axis specification" EXACT [GOC:mah] synonym: "left/right axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0060972 ! left/right pattern formation [Term] id: GO:0070987 name: error-free translesion synthesis namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level." [GOC:elh] comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication. subset: gosubset_prok is_a: GO:0019985 ! translesion synthesis [Term] id: GO:0070988 name: demethylation namespace: biological_process def: "The process of removing one or more methyl groups from a molecule." [GOC:BHF, GOC:rl] is_a: GO:0006730 ! one-carbon metabolic process [Term] id: GO:0070989 name: oxidative demethylation namespace: biological_process def: "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0055114 ! oxidation-reduction process is_a: GO:0070988 ! demethylation [Term] id: GO:0070990 name: snRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0043021 ! ribonucleoprotein binding [Term] id: GO:0070991 name: medium-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue." [GOC:BHF, GOC:mah] synonym: "MCAD activity" EXACT [GOC:mah] xref: EC:1.3.99.- is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0070992 name: translation initiation complex namespace: cellular_component def: "A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, GOC:mah] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070993 name: translation preinitiation complex namespace: cellular_component def: "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0070994 name: detection of oxidative stress namespace: biological_process def: "The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal." [GOC:mah] is_a: GO:0006979 ! response to oxidative stress [Term] id: GO:0070995 name: NADPH oxidation namespace: biological_process def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP." [GOC:BHF, GOC:mah] synonym: "NADP (reduced) dehydrogenation" EXACT [GOC:mah] synonym: "NADP (reduced) oxidation" EXACT [GOC:mah] synonym: "NADPH dehydrogenation" EXACT [GOC:mah] synonym: "reduced NADP dehydrogenation" EXACT [GOC:mah] synonym: "reduced NADP oxidation" EXACT [GOC:mah] synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenation" EXACT [GOC:mah] synonym: "reduced nicotinamide adenine dinucleotide phosphate oxidation" EXACT [GOC:mah] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0070996 name: type 1 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 melanocortin receptor." [GOC:BHF, GOC:mah] synonym: "type 1 melanocortin receptor ligand" NARROW [GOC:mah] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0070997 name: neuron death namespace: biological_process def: "The process of cell death in a neuron." [GOC:BHF, GOC:mah] synonym: "neuron cell death" EXACT [GOC:mah, GOC:rl] synonym: "neuronal cell death" EXACT [GOC:mah] is_a: GO:0008219 ! cell death [Term] id: GO:0070998 name: sensory perception of gravity namespace: biological_process def: "The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:mah] is_a: GO:0007600 ! sensory perception [Term] id: GO:0070999 name: detection of mechanical stimulus involved in sensory perception of gravity namespace: biological_process def: "The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:mah] is_a: GO:0009590 ! detection of gravity is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: part_of GO:0070998 ! sensory perception of gravity [Term] id: GO:0071000 name: response to magnetism namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:sl] synonym: "response to magnetic stimulus" EXACT [GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0071001 name: U4/U6 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains base-paired U4 and U6 small nuclear RNAs." [GOC:mah, PMID:14685174] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0071002 name: U4atac/U6atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains base-paired U4atac and U6atac small nuclear RNAs." [GOC:mah, PMID:14685174] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0071003 name: penta-snRNP complex namespace: cellular_component def: "A ribonucleoprotein complex formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:mah, PMID:11804584, PMID:12724403] synonym: "penta-RNP complex" EXACT [GOC:rb] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0071004 name: U2-type prespliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890] synonym: "GT-AG prespliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major prespliceosome" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "yeast U2-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071010 ! prespliceosome [Term] id: GO:0071005 name: U2-type precatalytic spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] synonym: "GT-AG precatalytic spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major precatalytic spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U2-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U12-type spliceosomal complex A2-1" RELATED [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071011 ! precatalytic spliceosome [Term] id: GO:0071006 name: U2-type catalytic step 1 spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] synonym: "GT-AG catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U2-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "U2-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U2-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071012 ! catalytic step 1 spliceosome [Term] id: GO:0071007 name: U2-type catalytic step 2 spliceosome namespace: cellular_component def: "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] synonym: "GT-AG catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U2-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U2-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071013 ! catalytic step 2 spliceosome [Term] id: GO:0071008 name: U2-type post-mRNA release spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "GT-AG post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "major post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071014 ! post-mRNA release spliceosomal complex [Term] id: GO:0071009 name: U4atac/U6atac x U5 tri-snRNP complex namespace: cellular_component def: "A ribonucleoprotein complex formed by the association of the U4atac/U6atac and U5 small nuclear ribonucleoproteins." [GOC:mah, PMID:16201866] synonym: "U4atac/U6atac . U5 snRNP complex" EXACT [] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0071010 name: prespliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890] synonym: "mammalian spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "yeast spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0071011 name: precatalytic spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] synonym: "mammalian spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0071012 name: catalytic step 1 spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] synonym: "activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393] synonym: "mammalian spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0071013 name: catalytic step 2 spliceosome namespace: cellular_component def: "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] synonym: "mammalian spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0071014 name: post-mRNA release spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0071015 name: U12-type prespliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:10197985, PMID:16201866] synonym: "AT-AC prespliceosome" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "minor prespliceosome" EXACT [GOC:krc, GOC:mah] synonym: "yeast U12-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071010 ! prespliceosome [Term] id: GO:0071016 name: U12-type precatalytic spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:16201866] synonym: "AT-AC precatalytic spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U12-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor precatalytic spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "yeast U12-type spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071011 ! precatalytic spliceosome [Term] id: GO:0071017 name: U12-type catalytic step 1 spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866] synonym: "AT-AC catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U12-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "U12-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U12-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071012 ! catalytic step 1 spliceosome [Term] id: GO:0071018 name: U12-type catalytic step 2 spliceosome namespace: cellular_component def: "A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866] synonym: "AT-AC catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U12-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "yeast U12-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071013 ! catalytic step 2 spliceosome [Term] id: GO:0071019 name: U12-type post-mRNA release spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866] synonym: "AT-AC post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0005691 ! U6atac snRNP is_a: GO:0005693 ! U12 snRNP is_a: GO:0071014 ! post-mRNA release spliceosomal complex [Term] id: GO:0071020 name: post-spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "mammalian spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0071021 name: U2-type post-spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "GT-AG post-spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "major post-spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U2-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071020 ! post-spliceosomal complex [Term] id: GO:0071022 name: U12-type post-spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "AT-AC post-spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor post-spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "yeast U12-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071020 ! post-spliceosomal complex [Term] id: GO:0071023 name: trans spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates." [GOC:krc, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0071024 name: SL snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains spliced leader (SL) RNA." [GOC:krc, ISBN:0879697393] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0071025 name: RNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant RNAs." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "RNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0071026 name: cytoplasmic RNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "cytoplasmic aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "cytoplasmic RNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071025 ! RNA surveillance [Term] id: GO:0071027 name: nuclear RNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear RNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071025 ! RNA surveillance [Term] id: GO:0071028 name: nuclear mRNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear aberrant mRNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear mRNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process is_a: GO:0071027 ! nuclear RNA surveillance [Term] id: GO:0071029 name: nuclear ncRNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear aberrant ncRNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear ncRNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0034661 ! ncRNA catabolic process is_a: GO:0071027 ! nuclear RNA surveillance [Term] id: GO:0071030 name: nuclear mRNA surveillance of spliceosomal pre-mRNA splicing namespace: biological_process def: "The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear mRNA quality control of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear RNA catabolic process of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071028 ! nuclear mRNA surveillance [Term] id: GO:0071031 name: nuclear mRNA surveillance of mRNA 3'-end processing namespace: biological_process def: "The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear mRNA catabolic process of mRNA with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear mRNA quality control of mRNAs with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071028 ! nuclear mRNA surveillance [Term] id: GO:0071032 name: nuclear mRNA surveillance of mRNP export namespace: biological_process def: "The set of processes involved in identifying and degrading incorrectly formed or aberrant nuclear mRNPs docked at the nuclear pore complex prior to export to the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear mRNA catabolic process of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear mRNA quality control of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071028 ! nuclear mRNA surveillance [Term] id: GO:0071033 name: nuclear retention of pre-mRNA at the site of transcription namespace: biological_process def: "The process involved in retention of aberrant or improperly formed mRNAs, e.g. those that are incorrectly or incompletely spliced or that have incorrectly formed 3'-ends, within the nucleus at the site of transcription." [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728, PMID:14718167, PMID:18644474] is_a: GO:0008298 ! intracellular mRNA localization relationship: part_of GO:0071028 ! nuclear mRNA surveillance [Term] id: GO:0071034 name: CUT catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs)." [GOC:dgf, GOC:krc] synonym: "cryptic unstable transcript catabolic process" EXACT [GOC:dgf, GOC:krc] is_a: GO:0034661 ! ncRNA catabolic process is_a: GO:0071043 ! CUT metabolic process [Term] id: GO:0071035 name: nuclear polyadenylation-dependent rRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA." [GOC:dgf, GOC:krc, PMID:15173578, PMID:15572680, PMID:15935758, PMID:17652137, PMID:18591258] is_a: GO:0016075 ! rRNA catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process [Term] id: GO:0071036 name: nuclear polyadenylation-dependent snoRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA." [GOC:dgf, GOC:krc, PMID:15935758] is_a: GO:0016077 ! snoRNA catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process [Term] id: GO:0071037 name: nuclear polyadenylation-dependent snRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA." [GOC:dgf, GOC:krc] is_a: GO:0016076 ! snRNA catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process [Term] id: GO:0071038 name: nuclear polyadenylation-dependent tRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA." [GOC:dgf, GOC:krc] is_a: GO:0016078 ! tRNA catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process [Term] id: GO:0071039 name: nuclear polyadenylation-dependent CUT catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258] is_a: GO:0071034 ! CUT catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process [Term] id: GO:0071040 name: nuclear polyadenylation-dependent antisense transcript catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript." [GOC:dgf, GOC:krc, PMID:18022365] is_a: GO:0071041 ! antisense RNA transcript catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process [Term] id: GO:0071041 name: antisense RNA transcript catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product." [GOC:dgf, GOC:krc] is_a: GO:0034661 ! ncRNA catabolic process is_a: GO:0042868 ! antisense RNA metabolic process [Term] id: GO:0071042 name: nuclear polyadenylation-dependent mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474] is_a: GO:0071047 ! polyadenylation-dependent mRNA catabolic process [Term] id: GO:0071043 name: CUT metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcribed from intergenic regions. Many intergenic regions are heavily transcribed, but the transcripts are rarely detected due to rapid degradation by the nuclear exosome." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0071044 name: histone mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA)." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process is_a: GO:0008334 ! histone mRNA metabolic process [Term] id: GO:0071045 name: nuclear histone mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393] is_a: GO:0071044 ! histone mRNA catabolic process [Term] id: GO:0071046 name: nuclear polyadenylation-dependent ncRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc, PMID:17410208] is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process is_a: GO:0071029 ! nuclear ncRNA surveillance [Term] id: GO:0071047 name: polyadenylation-dependent mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc] is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process [Term] id: GO:0071048 name: nuclear retention of unspliced pre-mRNA at the site of transcription namespace: biological_process def: "The process involved in retention of incorrectly or incompletely spliced pre-mRNA within the nucleus at the site of transcription." [GOC:dgf, GOC:krc, PMID:14718167] is_a: GO:0071033 ! nuclear retention of pre-mRNA at the site of transcription relationship: part_of GO:0071030 ! nuclear mRNA surveillance of spliceosomal pre-mRNA splicing [Term] id: GO:0071049 name: nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription namespace: biological_process def: "The process involved in retention of mRNAs that have incorrectly formed 3'-ends within the nucleus at the site of transcription." [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728] is_a: GO:0071033 ! nuclear retention of pre-mRNA at the site of transcription relationship: part_of GO:0071031 ! nuclear mRNA surveillance of mRNA 3'-end processing [Term] id: GO:0071050 name: snoRNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA molecule. In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation." [GOC:dgf, GOC:krc, PMID:18951092] is_a: GO:0043629 ! ncRNA polyadenylation [Term] id: GO:0071051 name: polyadenylation-dependent snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092] is_a: GO:0031126 ! snoRNA 3'-end processing [Term] id: GO:0071052 name: alpha9-beta1 integrin-ADAM1 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM1 complex" NARROW [CORUM:2964] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071053 name: alpha9-beta1 integrin-ADAM2 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM2 complex" NARROW [CORUM:2441] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071054 name: alpha9-beta1 integrin-ADAM3 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM3 complex" NARROW [CORUM:2965] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071055 name: alpha9-beta1 integrin-ADAM9 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM9 complex" NARROW [CORUM:2440] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071056 name: alpha9-beta1 integrin-ADAM15 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM15 complex" NARROW [CORUM:2445] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071057 name: alphav-beta3 integrin-ADAM15 complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:10944520, PMID:11882657] synonym: "ITGAV-ITGB3-ADAM15 complex" NARROW [CORUM:2359] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071058 name: alpha3-beta1 integrin-CD151 complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151." [PMID:10811835, PMID:11884516] synonym: "ITGA3-ITGB1-CD151 complex" NARROW [CORUM:2400] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071059 name: alpha6-beta1 integrin-CD151 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516] synonym: "ITGA6-ITGB1-CD151 complex" NARROW [CORUM:2411] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071060 name: alpha7-beta1 integrin-CD151 complex namespace: cellular_component def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516] synonym: "ITGA7-ITGB1-CD151 complex" NARROW [CORUM:2395] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071061 name: alpha6-beta4 integrin-CD151 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151." [PMID:10811835] synonym: "ITGA6-ITGB4-CD151 complex" NARROW [CORUM:2320] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071062 name: alphav-beta3 integrin-vitronectin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin." [PMID:10835423] synonym: "ITGAV-ITGB3-VTN complex" NARROW [CORUM:2826] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071063 name: sensory perception of wind namespace: biological_process def: "The series of events required for an organism to receive sensory mechanical stimulus resulting from air flow, convert it to a molecular signal, and recognize and characterize the signal." [GOC:mah, PMID:19279637] synonym: "perception of wind" EXACT [GOC:mah] synonym: "sensory perception of air flow" EXACT [GOC:mah, PMID:19279637] is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0071064 name: alphaE-beta7 integrin-E-cadherin complex namespace: cellular_component def: "A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin." [PMID:10837471] synonym: "ITGAE-ITGB7-CDH1 complex" NARROW [CORUM:1834] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071065 name: alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1." [PMID:10209034] synonym: "ITGA9-ITGB1-VCAM1 complex" NARROW [CORUM:2442] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071066 name: detection of mechanical stimulus involved in sensory perception of wind namespace: biological_process def: "The series of events involved in the perception of wind in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:mah, PMID:19279637] synonym: "detection of mechanical stimulus involved in sensory perception of air flow" EXACT [GOC:mah] synonym: "detection of wind" EXACT [GOC:mah] synonym: "perception of wind, detection of mechanical stimulus" EXACT [GOC:mah] synonym: "perception of wind, sensory detection of mechanical stimulus" EXACT [GOC:mah] synonym: "perception of wind, sensory transduction of mechanical stimulus" EXACT [GOC:mah] synonym: "sensory detection of mechanical stimulus during perception of wind" EXACT [GOC:mah] synonym: "sensory transduction of mechanical stimulus during perception of wind" EXACT [GOC:mah] synonym: "sensory transduction of wind" EXACT [GOC:mah] is_a: GO:0050877 ! neurological system process is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: part_of GO:0071063 ! sensory perception of wind [Term] id: GO:0071067 name: alphav-beta3 integrin-ADAM23 complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23." [PMID:10749942] synonym: "ITGAV-ITGB3-ADAM23 complex" NARROW [CORUM:2364] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071068 name: alpha9-beta1 integrin-ADAM12 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12." [PMID:10944520] synonym: "ITGA9-ITGB1-ADAM12 complex" NARROW [CORUM:2447] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071069 name: alpha4-beta1 integrin-thrombospondin-1 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1." [PMID:11980922] synonym: "ITGA4-ITGB1-THBS1 complex" NARROW [CORUM:2426] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071070 name: alpha4-beta1 integrin-thrombospondin-2 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2." [PMID:11980922] synonym: "ITGA4-ITGB1-THBS2 complex" NARROW [CORUM:2428] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071071 name: regulation of phospholipid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah] subset: gosubset_prok synonym: "regulation of phospholipid anabolism" EXACT [GOC:mah] synonym: "regulation of phospholipid biosynthesis" EXACT [GOC:mah] synonym: "regulation of phospholipid formation" EXACT [GOC:mah] synonym: "regulation of phospholipid synthesis" EXACT [GOC:mah] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0008654 ! phospholipid biosynthetic process [Term] id: GO:0071072 name: negative regulation of phospholipid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah] subset: gosubset_prok synonym: "down regulation of phospholipid biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of phospholipid biosynthetic process" EXACT [GOC:ma] synonym: "downregulation of phospholipid biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of phospholipid biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of phospholipid anabolism" EXACT [GOC:mah] synonym: "negative regulation of phospholipid biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of phospholipid formation" EXACT [GOC:mah] synonym: "negative regulation of phospholipid synthesis" EXACT [GOC:mah] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process relationship: negatively_regulates GO:0008654 ! phospholipid biosynthetic process [Term] id: GO:0071073 name: positive regulation of phospholipid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah] subset: gosubset_prok synonym: "activation of phospholipid biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of phospholipid anabolism" EXACT [GOC:mah] synonym: "positive regulation of phospholipid biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of phospholipid formation" EXACT [GOC:mah] synonym: "positive regulation of phospholipid synthesis" EXACT [GOC:mah] synonym: "stimulation of phospholipid biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of phospholipid biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of phospholipid biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of phospholipid biosynthetic process" EXACT [GOC:mah] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process relationship: positively_regulates GO:0008654 ! phospholipid biosynthetic process [Term] id: GO:0071074 name: eukaryotic initiation factor eIF2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd] is_a: GO:0031369 ! translation initiation factor binding [Term] id: GO:0071075 name: CUGBP1-eIF2 complex namespace: cellular_component def: "A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation." [PMID:16931514] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0071076 name: RNA 3' uridylation namespace: biological_process def: "The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule." [GOC:vw, PMID:19430462] is_a: GO:0031123 ! RNA 3'-end processing [Term] id: GO:0071077 name: adenosine 3',5'-bisphosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other." [CHEBI:37240, GOC:mah, PubChem_Compound:159296] synonym: "adenosine 3',5'-diphosphate transporter activity" EXACT [PubChem_Compound:159296] synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity" EXACT [PubChem_Compound:159296] is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity [Term] id: GO:0071078 name: fibronectin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion." [PMID:10684262] synonym: "FN-TGM2 complex" NARROW [CORUM:2375] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071079 name: alpha2-beta1 integrin-chondroadherin complex namespace: cellular_component def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin." [PMID:9281592] synonym: "ITGA2-ITGB1-CHAD complex" NARROW [CORUM:2430] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071080 name: alpha3-beta1 integrin-basigin complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin." [PMID:9360995] synonym: "ITGA3-ITGB1-BSG complex" NARROW [CORUM:2398] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071081 name: alpha3-beta1 integrin-CD63 complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63." [PMID:7629079] synonym: "ITGA3-ITGB1-CD63 complex" NARROW [CORUM:2399] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071082 name: alpha9-beta1 integrin-tenascin complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin." [PMID:9565552] synonym: "ITGA9-ITGB1-TNC complex" NARROW [CORUM:2443] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071083 name: alphaV-beta3 integrin-CD47-FCER2 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2)." [PMID:10037797] synonym: "ITGAV-ITGB3-CD447-FCER2 complex" NARROW [CORUM:2355] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071084 name: alpha2-beta1 integrin-CD47 complex namespace: cellular_component def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47." [PMID:10397731] synonym: "ITGA2-ITGB1-CD47 complex" NARROW [CORUM:2429] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071085 name: alphaIIb-beta3 integrin-CD9 complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9." [PMID:10429193] synonym: "ITGA2b-ITGB3-CD9 complex" NARROW [CORUM:2370] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071086 name: alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib." [PMID:10429193] synonym: "ITGA2b-ITGB3-CD9-GP1b-CD47 complex" NARROW [CORUM:2872] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071087 name: alpha11-beta1 integrin-collagen type I complex namespace: cellular_component def: "A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen." [PMID:10464311] synonym: "ITGA11-ITGB1-COL1A1 complex" NARROW [CORUM:3059] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071088 name: alpha5-beta1 integrin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262] synonym: "ITGA5-ITGB1-TGM2 complex" NARROW [CORUM:2433] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071089 name: alphaV-beta3 integrin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase." [PMID:10684262] synonym: "ITGAV-ITGB3-TGM2 complex" NARROW [CORUM:3095] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071090 name: alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262] synonym: "ITGA2b-ITGB3-FN1-TGM2 complex" NARROW [CORUM:2376] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071091 name: alpha1-beta1 integrin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262] synonym: "ITGA1-ITGB1-TGM2 complex" NARROW [CORUM:2894] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071092 name: alpha3-beta1 integrin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262] synonym: "ITGA3-ITGB1-TGM2 complex" NARROW [CORUM:2402] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071093 name: alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262] synonym: "ITGA5-ITGB1-FN1-TGM2 complex" NARROW [CORUM:2383] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071094 name: alpha6-beta4 integrin-CD9 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9." [PMID:10711425] synonym: "ITGA6-ITGB4-CD9 complex" NARROW [CORUM:2770] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071095 name: alpha3-beta1 integrin-thrombospondin complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin." [PMID:11358957] synonym: "ITGA3-ITGB1-THBS1 complex" NARROW [CORUM:2401] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071096 name: alphaV-beta3 integrin-gelsolin complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin." [PMID:11577104] synonym: "ITGAV-ITGB3-Gsn complex" NARROW [CORUM:2360] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071097 name: alphaV-beta3 integrin-paxillin-Pyk2 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2." [PMID:11683411] synonym: "ITGAV-ITGB3-PXN-PTK2b complex" NARROW [CORUM:2363] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071098 name: alpha6-beta4 integrin-Fyn complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn." [PMID:11684709] synonym: "ITGA6-ITGB4-FYN complex" NARROW [CORUM:2321] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071099 name: alphaV-beta6 integrin-TGFbeta-3 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3)." [PMID:11821050] synonym: "ITGAV-ITGB6-TFGB3 complex" NARROW [CORUM:2353] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071100 name: alphaV-beta8 integrin-MMP14-TGFbeta-1 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1)." [PMID:11970960] synonym: "ITGAV-ITGB8-MMP14-TGFB1 complex" NARROW [CORUM:2342] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071101 name: alpha4-beta1 integrin-JAM2 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2." [PMID:12070135] synonym: "ITGA4-ITGB1-JAM2 complex" NARROW [CORUM:2422] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071102 name: alpha4-beta1 integrin-paxillin complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin." [PMID:12221126] synonym: "ITGA4-ITGB1-PXN complex" NARROW [CORUM:2425] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071103 name: DNA conformation change namespace: biological_process def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah] subset: gosubset_prok synonym: "DNA conformation modification" EXACT [GOC:mah] is_a: GO:0009987 ! cellular process [Term] id: GO:0071104 name: response to interleukin-9 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah] synonym: "response to IL-9" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0071105 name: response to interleukin-11 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah] synonym: "response to IL-11" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0071106 name: adenosine 3',5'-bisphosphate transmembrane transport namespace: biological_process def: "The directed movement of adenosine 3',5'-bisphosphate across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:37240, GOC:mah, PubChem_Compound:159296] synonym: "adenosine 3',5'-diphosphate transport" EXACT [PubChem_Compound:159296] synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transport" EXACT [PubChem_Compound:159296] is_a: GO:0035427 ! purine nucleoside transmembrane transport [Term] id: GO:0071107 name: response to parathyroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0071108 name: protein K48-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah] is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0071109 name: superior temporal gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus." [FMA:61905, GOC:BHF, GOC:mah, PMID:11484000] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021987 ! cerebral cortex development [Term] id: GO:0071110 name: histone biotinylation namespace: biological_process def: "The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041] is_a: GO:0009305 ! protein biotinylation is_a: GO:0016570 ! histone modification [Term] id: GO:0071111 name: cyclic-guanylate-specific phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)." [EC:3.1.4.52, RHEA:24905] subset: gosubset_prok synonym: "c-di-GMP phosphodiesterase activity" EXACT [EC:3.1.4.52] synonym: "c-di-GMP-specific phosphodiesterase activity" EXACT [EC:3.1.4.52] synonym: "cyclic bis(3->5')diguanylate phosphodiesterase activity" EXACT [EC:3.1.4.52] synonym: "PDEA1" RELATED [EC:3.1.4.52] synonym: "phosphodiesterase A1 activity" RELATED [EC:3.1.4.52] synonym: "VieA" RELATED [EC:3.1.4.52] xref: EC:3.1.4.52 xref: KEGG:R08991 xref: MetaCyc:RXN0-4181 xref: RHEA:24905 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0071112 name: alpha4-beta4 integrin-EMILIN-1 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN)." [PMID:12456677] synonym: "ITGA4-ITGB4-EMILIN1 complex" NARROW [CORUM:2417] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071113 name: alphaIIb-beta3 integrin-ICAM-4 complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4." [PMID:12477717] synonym: "ITGAIIb-ITGB3-ICAM4 complex" NARROW [CORUM:3115] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071114 name: alphaV-beta3 integrin-tumstatin complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen." [PMID:12682293] synonym: "ITGAV-ITGB3-COL4A3 complex" NARROW [CORUM:2365] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071115 name: alpha5-beta1 integrin-endostatin complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen." [PMID:12682293] synonym: "ITGA5-ITGB1-CAL4A3 complex" NARROW [CORUM:2853] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071116 name: alpha6-beta1 integrin-CYR61 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis." [PMID:12826661] synonym: "ITGA6-ITGB1-CYR61 complex" NARROW [CORUM:2437] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071117 name: alpha5-beta1 integrin-fibronectin-NOV complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV." [PMID:12902636] synonym: "ITGA5-ITGB1-FN-1-NOV complex" NARROW [CORUM:2850] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071118 name: alphaV-beta3 integrin-NOV complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV." [PMID:12902636] synonym: "ITGAV-ITGB3-FN-1-NOV complex" NARROW [CORUM:2849] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071119 name: alpha7-beta1 integrin-nicotinamide riboside kinase complex namespace: cellular_component def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP)." [PMID:12941630] synonym: "ITGA7-ITGB1-ITGB1BP3 complex" NARROW [CORUM:2397] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071120 name: alpha4-beta1 integrin-CD47 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47." [PMID:15292185] synonym: "ITGA4-ITGB1-CB47 complex" NARROW [CORUM:2423] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071121 name: alpha9-beta1 integrin-VEGF-D complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D." [PMID:15590642] synonym: "ITGA9-ITGB1-FIGF complex" NARROW [CORUM:2446] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071122 name: alpha9-beta1 integrin-VEGF-A complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A." [PMID:17363377] synonym: "ITGA9-ITGB1-VEGFA complex" NARROW [CORUM:2972] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071123 name: alpha9-beta1 integrin-VEGF-C complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C." [PMID:15590642] synonym: "ITGA9-ITGB1-VEGFC complex" NARROW [CORUM:2971] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071124 name: alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex namespace: cellular_component def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2." [PMID:15592458] synonym: "ITGA1-ITGB1-PTPN2 complex" NARROW [CORUM:2435] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071125 name: alphaV-beta3 integrin-EGFR complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor." [PMID:15834425] synonym: "ITGAV-ITGB3-EGFR complex" NARROW [CORUM:2369] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071126 name: alphaV-beta6 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin." [PMID:16005200] synonym: "ITGAV-ITGB6-SPP1 complex" NARROW [CORUM:2352] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071127 name: alpha9-beta1 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin." [PMID:16005200] synonym: "ITGA9-ITGB1-SPP1 complex" NARROW [CORUM:3111] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071128 name: alpha5-beta1 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin." [PMID:16005200] synonym: "ITGA5-ITGB1-SPP1 complex" NARROW [CORUM:3112] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071129 name: alphaV-beta3 integrin-LPP3 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422] synonym: "ITGAV-ITGB3-PPAP2B complex" NARROW [CORUM:2366] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071130 name: alpha5-beta1 integrin-LPP3 complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422] synonym: "ITGA5-ITGB1-PPAP2B complex" NARROW [CORUM:2386] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071131 name: alphaV-beta3 integrin-laminin alpha-4 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4." [PMID:16824487] synonym: "ITGAV-ITGB3-LAMA4 complex" NARROW [CORUM:2374] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071132 name: alphaX-beta2 integrin-ICAM-4 complex namespace: cellular_component def: "A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4." [PMID:16985175] synonym: "ITGAX-ITGB2-ICAM4 complex" NARROW [CORUM:3114] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071133 name: alpha9-beta1 integrin-ADAM8 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8." [PMID:16995821] synonym: "ITGA9-ITGB1-ADAM8 complex" NARROW [CORUM:2989] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071134 name: alpha9-beta1 integrin-thrombospondin-1 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1." [PMID:17413041] synonym: "ITGA9-ITGB1-THBS1 complex" NARROW [CORUM:2967] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071135 name: alpha7-beta1 integrin-focal adhesion kinase complex namespace: cellular_component def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase." [PMID:17598176] synonym: "ITGA7-ITGB1-PTK2 complex" NARROW [CORUM:3106] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071136 name: alpha7-beta1 integrin-laminin alpha-2 complex namespace: cellular_component def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2." [PMID:17598176] synonym: "ITGA7-ITGB1-LAMA2 complex" NARROW [CORUM:3105] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071137 name: alphaV-beta3 integrin-CD98 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98." [PMID:18032696] synonym: "ITGAV-ITGB3-SLC3A2 complex" NARROW [CORUM:3103] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071138 name: alpha5-beta5-fibronectin-SFRP2 complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2." [PMID:14709558] synonym: "ITGA5-ITGB5-FN-1-SFRP2 complex" NARROW [CORUM:2388] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071139 name: resolution of recombination intermediates namespace: biological_process def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw] is_a: GO:0051304 ! chromosome separation relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0071140 name: resolution of mitotic recombination intermediates namespace: biological_process def: "The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw] is_a: GO:0071139 ! resolution of recombination intermediates relationship: part_of GO:0006312 ! mitotic recombination [Term] id: GO:0071141 name: SMAD protein complex namespace: cellular_component def: "A protein complex that consists of SMAD proteins; may be homomeric or heteromeric." [GOC:mah, PMID:9670020] synonym: "SMAD complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0071142 name: SMAD2 protein complex namespace: cellular_component def: "A protein complex that consists of a SMAD2 homotrimer." [GOC:mah, PMID:9670020] synonym: "SMAD2 homotrimer complex" EXACT [CORUM:2999] is_a: GO:0071141 ! SMAD protein complex [Term] id: GO:0071143 name: SMAD3 protein complex namespace: cellular_component def: "A protein complex that consists of a SMAD3 homotrimer." [GOC:mah, PMID:9670020] synonym: "SMAD3 homotrimer complex" EXACT [CORUM:3003] is_a: GO:0071141 ! SMAD protein complex [Term] id: GO:0071144 name: SMAD2-SMAD3 protein complex namespace: cellular_component def: "A heteromeric SMAD protein complex that contains SMAD2 and SMAD3." [GOC:mah, PMID:9670020] synonym: "SMAD2-SMAD3 complex" EXACT [CORUM:3000] is_a: GO:0071141 ! SMAD protein complex [Term] id: GO:0071145 name: SMAD2-SMAD4 protein complex namespace: cellular_component def: "A heteromeric SMAD protein complex that contains SMAD2 and SMAD4." [GOC:mah, PMID:9670020] synonym: "SMAD2-SMAD4 heteromer complex" EXACT [CORUM:3001] is_a: GO:0071141 ! SMAD protein complex [Term] id: GO:0071146 name: SMAD3-SMAD4 protein complex namespace: cellular_component def: "A heteromeric SMAD protein complex that contains SMAD3 and SMAD4." [GOC:mah, PMID:9670020] synonym: "SMAD3-SMAD4 complex" EXACT [CORUM:3002] is_a: GO:0071141 ! SMAD protein complex [Term] id: GO:0071147 name: TEAD-2 multiprotein complex namespace: cellular_component def: "A protein complex that consists of the DNA binding protein TEAD-2 bound to 12 other polypeptides including the transcriptional coactivator YAP, the multi-PDZ domain protein MPDZ (also called MUPP1), a 14-3-3 domain protein, and others." [CORUM:2870, GOC:mah, PMID:11358867] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0071148 name: TEAD-1-YAP complex namespace: cellular_component def: "A transcription factor complex that is composed of the DNA biding protein TEAD-1 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0071149 name: TEAD-2-YAP complex namespace: cellular_component def: "A transcription factor complex that is composed of the DNA biding protein TEAD-2 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0071150 name: TEAD-3-YAP complex namespace: cellular_component def: "A transcription factor complex that is composed of the DNA biding protein TEAD-3 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0071151 name: TEAD-4-YAP complex namespace: cellular_component def: "A transcription factor complex that is composed of the DNA biding protein TEAD-4 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0071152 name: G-protein alpha(q)-synembrin complex namespace: cellular_component def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] synonym: "Ric-8A G(q) alpha subunit complex" NARROW [CORUM:175] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0071153 name: G-protein alpha(o)-synembrin complex namespace: cellular_component def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] synonym: "Ric-8A G(o) alpha-1 subunit complex" NARROW [CORUM:172] synonym: "Ric-8A G(o) alpha-2 subunit complex" NARROW [CORUM:174] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0071154 name: G-protein alpha(i)1-synembrin complex namespace: cellular_component def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] synonym: "Ric-8A G(i) alpha-1 subunit complex" NARROW [CORUM:170] synonym: "Ric-8A G(i) alpha-2 subunit complex" RELATED [CORUM:171] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0071155 name: G-protein alpha(13)-synembrin complex namespace: cellular_component def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] synonym: "Ric-8A G alpha 13 subunit complex" NARROW [CORUM:176] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0071156 name: regulation of cell cycle arrest namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process relationship: regulates GO:0007050 ! cell cycle arrest [Term] id: GO:0071157 name: negative regulation of cell cycle arrest namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0071156 ! regulation of cell cycle arrest relationship: negatively_regulates GO:0007050 ! cell cycle arrest [Term] id: GO:0071158 name: positive regulation of cell cycle arrest namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah] is_a: GO:0071156 ! regulation of cell cycle arrest is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0007050 ! cell cycle arrest [Term] id: GO:0071159 name: NF-kappaB complex namespace: cellular_component def: "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0071160 name: cyanophycin synthetase activity (L-aspartate-adding) namespace: molecular_function def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp." [EC:6.3.2.29] subset: gosubset_prok xref: EC:6.3.1.29 is_a: GO:0043860 ! cyanophycin synthetase activity [Term] id: GO:0071161 name: cyanophycin synthetase activity (L-arginine-adding) namespace: molecular_function def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1." [EC:6.3.2.30] subset: gosubset_prok xref: EC:6.3.1.30 is_a: GO:0043860 ! cyanophycin synthetase activity [Term] id: GO:0071162 name: CMG complex namespace: cellular_component def: "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [PMID:19228417] synonym: "unwindosome" EXACT [PMID:19228417] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0071163 name: DNA replication preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication, by the assembly of additional proteins onto an existing prereplicative complex." [GOC:mah] synonym: "DNA replication preinitiation complex formation" EXACT [GOC:mah] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0071164 name: RNA trimethylguanosine synthase activity namespace: molecular_function def: "Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine." [GOC:BHF, PMID:11983179, PMID:18775984] synonym: "cap hypermethylase activity" EXACT [PMID:11983179] synonym: "small nuclear RNA methyltransferase activity" RELATED [GOC:rl] synonym: "snRNA methyltransferase activity" RELATED [GOC:rl] is_a: GO:0008173 ! RNA methyltransferase activity [Term] id: GO:0071165 name: GINS complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks." [GOC:mah, PMID:16990792] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0071166 name: ribonucleoprotein complex localization namespace: biological_process def: "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah] synonym: "cellular ribonucleoprotein complex localization" EXACT [GOC:mah] synonym: "establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "RNP localization" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization [Term] id: GO:0071167 name: ribonucleoprotein complex import into nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex from the cytoplasm to the nucleus." [GOC:BHF, GOC:mah] synonym: "ribonucleoprotein complex import into cell nucleus" EXACT [GOC:mah] synonym: "ribonucleoprotein complex nucleus import" EXACT [GOC:mah] synonym: "ribonucleoprotein complex targeting to nucleus" EXACT [GOC:mah] synonym: "ribonucleoprotein complex transport from cytoplasm to nucleus" EXACT [GOC:mah] synonym: "ribonucleoprotein import into nucleus" EXACT [GOC:rl] synonym: "RNP import into nucleus" EXACT [GOC:mah] is_a: GO:0051170 ! nuclear import is_a: GO:0071166 ! ribonucleoprotein complex localization [Term] id: GO:0071168 name: protein localization to chromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome [Term] id: GO:0071169 name: establishment of protein localization to chromatin namespace: biological_process def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0070199 ! establishment of protein localization to chromosome relationship: part_of GO:0071168 ! protein localization to chromatin [Term] id: GO:0071170 name: site-specific DNA replication termination namespace: biological_process def: "A DNA replication termination process that takes place at a specific termination site." [GOC:mah, PMID:12009298, PMID:18723894] comment: See also the biological process term 'replication fork arrest ; GO:0043111' and its children. is_a: GO:0006274 ! DNA replication termination [Term] id: GO:0071171 name: site-specific DNA replication termination at RTS1 barrier namespace: biological_process def: "A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching." [GOC:vw, PMID:12009298, PMID:18723894] is_a: GO:0071170 ! site-specific DNA replication termination relationship: part_of GO:0071516 ! establishment of imprinting at mating-type locus [Term] id: GO:0071172 name: dihydromonapterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+." [GOC:imk, PMID:19897652] subset: gosubset_prok is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0071173 name: spindle assembly checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah] synonym: "SAC" BROAD [GOC:mah] is_a: GO:0031577 ! spindle checkpoint [Term] id: GO:0071174 name: mitotic cell cycle spindle checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:mah] synonym: "mitotic spindle checkpoint" EXACT [GOC:mah] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0031577 ! spindle checkpoint [Term] id: GO:0071175 name: MAML2-RBP-Jkappa-ICN1 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML2-RBP-Jkappa-Notch1 complex" EXACT [CORUM:1949] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071176 name: MAML2-RBP-Jkappa-ICN2 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML2-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3217] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071177 name: MAML2-RBP-Jkappa-ICN3 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML2-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3218] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071178 name: MAML2-RBP-Jkappa-ICN4 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML2-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3219] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071179 name: MAML3-RBP-Jkappa-ICN1 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML3-RBP-Jkappa-Notch1 complex" EXACT [CORUM:3220] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071180 name: MAML3-RBP-Jkappa-ICN2 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML3-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3221] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071181 name: MAML3-RBP-Jkappa-ICN3 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML3-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3222] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071182 name: MAML3-RBP-Jkappa-ICN4 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML3-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3223] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071183 name: protocadherin-alpha-protocadherin-gamma complex namespace: cellular_component def: "A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0071184 name: protocadherin-alpha-v4-protocadherin-gamma-a1 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdhga1-Pcdha4 complex" NARROW [CORUM:1014] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex [Term] id: GO:0071185 name: protocadherin-alpha-v4-protocadherin-gamma-a3 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdhga1-Pcdhga3 complex" NARROW [CORUM:1016] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex [Term] id: GO:0071186 name: protocadherin-alpha-v4-protocadherin-gamma-b2 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdhga1-Pcdhgb2 complex" NARROW [CORUM:1015] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex [Term] id: GO:0071187 name: protocadherin-alpha-v4-protocadherin-gamma-b4 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdhga1-Pcdhgb4 complex" NARROW [CORUM:1017] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex [Term] id: GO:0071188 name: protocadherin-alpha-v7-protocadherin-gamma-a1 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdha7-Pcdhga1 complex" NARROW [CORUM:1021] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex [Term] id: GO:0071189 name: protocadherin-alpha-v7-protocadherin-gamma-a3 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdha7-Pcdhga3 complex" NARROW [CORUM:1019] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex [Term] id: GO:0071190 name: protocadherin-alpha-v7-protocadherin-gamma-b2 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdha7-Pcdhgb4 complex" NARROW [CORUM:1018] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex [Term] id: GO:0071191 name: protocadherin-alpha-v7-protocadherin-gamma-b4 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdha7-Pcdhgb2 complex" NARROW [CORUM:1020] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex [Term] id: GO:0071192 name: Kv4.2-KChIP1 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] xref: CORUM:606 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071193 name: Kv4.2-KChIP2 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] xref: CORUM:607 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071194 name: Kv4.2-KChIP3 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] xref: CORUM:608 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071195 name: Kv4.2-KChIP4 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] xref: CORUM:3090 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071196 name: Kv4.3-KChIP1 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15356203] xref: CORUM:3091 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071197 name: Kv4.2-Kv4.3 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3." [PMID:15356203] xref: CORUM:609 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071198 name: Kv4.1-DPP6 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355] synonym: "Kv4.1-DPPX channel complex" EXACT [PMID:15911355] xref: CORUM:600 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071199 name: Kv4.1-DPP10 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355] synonym: "Kv4.1-DPPY channel complex" EXACT [PMID:15911355] xref: CORUM:601 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071200 name: Kv4.2-DPP6 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:12575952, PMID:15911355] synonym: "Kv4.2-DPPX channel complex" EXACT [PMID:15911355] xref: CORUM:603 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071201 name: Kv4.3-DPP6 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:12575952, PMID:15911355] synonym: "Kv4.3-DPPX channel complex" EXACT [PMID:15911355] xref: CORUM:599 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071202 name: Kv4.3-DPP10 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15911355] synonym: "Kv4.3-DPPY channel complex" EXACT [PMID:15911355] xref: CORUM:598 is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0071203 name: WASH complex namespace: cellular_component def: "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0071204 name: histone pre-mRNA 3'end processing complex namespace: cellular_component def: "A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1." [GOC:mah, PMID:19470752] synonym: "histone 3'end pre-mRNA complex" EXACT [GOC:mah] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0071205 name: protein localization to juxtaparanode region of axon namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon." [GOC:BHF, GOC:mah] synonym: "protein localisation to juxtaparanode region of axon" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0071206 name: establishment of protein localization to juxtaparanode region of axon namespace: biological_process def: "The directed movement of a protein to the juxtaparanode region of an axon." [GOC:BHF, GOC:mah] synonym: "establishment of protein localisation to juxtaparanode region of axon" EXACT [GOC:mah] is_a: GO:0045184 ! establishment of protein localization relationship: part_of GO:0071205 ! protein localization to juxtaparanode region of axon [Term] id: GO:0071207 name: histone pre-mRNA stem-loop binding namespace: molecular_function def: "Interacting selectively and non-covalently with a conserved stem-loop structure found in histone pre-mRNAs." [PMID:19470752] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0071208 name: histone pre-mRNA DCP binding namespace: molecular_function def: "Interacting selectively and non-covalently with the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing." [PMID:19470752] is_a: GO:0003723 ! RNA binding [Term] id: GO:0071209 name: U7 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U7 small nuclear RNA (U7 snRNA)." [GOC:mah, PMID:12975319] comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). is_a: GO:0017069 ! snRNA binding [Term] id: GO:0071210 name: protein insertion into membrane raft namespace: biological_process def: "The process in which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah] synonym: "establishment of protein localization to membrane raft" EXACT [GOC:mah, GOC:vw] is_a: GO:0051205 ! protein insertion into membrane [Term] id: GO:0071211 name: protein targeting to vacuole involved in autophagy namespace: biological_process def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm." [GOC:mah] is_a: GO:0006623 ! protein targeting to vacuole relationship: part_of GO:0006914 ! autophagy [Term] id: GO:0071212 name: subsynaptic reticulum namespace: cellular_component def: "An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331] synonym: "SSR" EXACT [PMID:19244343] is_a: GO:0033267 ! axon part is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044456 ! synapse part relationship: part_of GO:0061174 ! type I terminal button [Term] id: GO:0071213 name: cellular response to 1-aminocyclopropane-1-carboxylic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:mah] is_a: GO:0009961 ! response to 1-aminocyclopropane-1-carboxylic acid is_a: GO:0071230 ! cellular response to amino acid stimulus [Term] id: GO:0071214 name: cellular response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to abiotic stress" NARROW [GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0071215 name: cellular response to abscisic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:mah] is_a: GO:0009737 ! response to abscisic acid stimulus is_a: GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0071216 name: cellular response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah] synonym: "cellular response to biotic stress" NARROW [GOC:mah] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0071217 name: cellular response to external biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:mah] is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0071216 ! cellular response to biotic stimulus is_a: GO:0071496 ! cellular response to external stimulus [Term] id: GO:0071218 name: cellular response to misfolded protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0051788 ! response to misfolded protein is_a: GO:0071216 ! cellular response to biotic stimulus is_a: GO:0071445 ! cellular response to protein stimulus [Term] id: GO:0071219 name: cellular response to molecule of bacterial origin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:mah] synonym: "cellular response to bacteria associated molecule" EXACT [GOC:mah] synonym: "cellular response to bacterial associated molecule" EXACT [GOC:mah] synonym: "cellular response to bacterium associated molecule" EXACT [GOC:mah] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:0071216 ! cellular response to biotic stimulus [Term] id: GO:0071220 name: cellular response to bacterial lipoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:mah] is_a: GO:0032493 ! response to bacterial lipoprotein is_a: GO:0071219 ! cellular response to molecule of bacterial origin [Term] id: GO:0071221 name: cellular response to bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:mah] is_a: GO:0070339 ! response to bacterial lipopeptide is_a: GO:0071220 ! cellular response to bacterial lipoprotein [Term] id: GO:0071222 name: cellular response to lipopolysaccharide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah] synonym: "cellular response to endotoxin" BROAD [GOC:mah, GOC:sl] synonym: "cellular response to LPS" EXACT [GOC:mah] is_a: GO:0032496 ! response to lipopolysaccharide is_a: GO:0071219 ! cellular response to molecule of bacterial origin [Term] id: GO:0071223 name: cellular response to lipoteichoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:mah] synonym: "cellular response to LTA" EXACT [GOC:mah] is_a: GO:0070391 ! response to lipoteichoic acid is_a: GO:0071219 ! cellular response to molecule of bacterial origin [Term] id: GO:0071224 name: cellular response to peptidoglycan namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:mah] is_a: GO:0032494 ! response to peptidoglycan is_a: GO:0071219 ! cellular response to molecule of bacterial origin [Term] id: GO:0071225 name: cellular response to muramyl dipeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:mah] is_a: GO:0032495 ! response to muramyl dipeptide is_a: GO:0071224 ! cellular response to peptidoglycan [Term] id: GO:0071226 name: cellular response to molecule of fungal origin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:mah] synonym: "cellular response to fungus associated molecule" EXACT [GOC:mah] is_a: GO:0002238 ! response to molecule of fungal origin is_a: GO:0071216 ! cellular response to biotic stimulus [Term] id: GO:0071227 name: cellular response to molecule of oomycetes origin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:mah] synonym: "cellular response to oomycetes associated molecule" EXACT [GOC:mah] is_a: GO:0002240 ! response to molecule of oomycetes origin is_a: GO:0071216 ! cellular response to biotic stimulus is_a: GO:0071310 ! cellular response to organic substance relationship: part_of GO:0009620 ! response to fungus [Term] id: GO:0071228 name: cellular response to tumor cell namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:mah] is_a: GO:0002347 ! response to tumor cell is_a: GO:0071216 ! cellular response to biotic stimulus [Term] id: GO:0071229 name: cellular response to acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus." [GOC:mah] is_a: GO:0001101 ! response to acid is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0071230 name: cellular response to amino acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah] synonym: "cellular response to amino acid" EXACT [GOC:mah] is_a: GO:0043200 ! response to amino acid stimulus is_a: GO:0071229 ! cellular response to acid is_a: GO:0071418 ! cellular response to amine stimulus [Term] id: GO:0071231 name: cellular response to folic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:mah] synonym: "response to folate" EXACT [GOC:mah] synonym: "response to vitamin B9" EXACT [GOC:mah] is_a: GO:0051593 ! response to folic acid is_a: GO:0071229 ! cellular response to acid is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071232 name: cellular response to histidine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [GOC:mah] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0080052 ! response to histidine [Term] id: GO:0071233 name: cellular response to leucine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mah] is_a: GO:0043201 ! response to leucine is_a: GO:0071230 ! cellular response to amino acid stimulus [Term] id: GO:0071234 name: cellular response to phenylalanine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [GOC:mah] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0080053 ! response to phenylalanine [Term] id: GO:0071235 name: cellular response to proline namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:mah] is_a: GO:0010238 ! response to proline is_a: GO:0071230 ! cellular response to amino acid stimulus [Term] id: GO:0071236 name: cellular response to antibiotic namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:mah] subset: gosubset_prok is_a: GO:0046677 ! response to antibiotic is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0071237 name: cellular response to bacteriocin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [GOC:mah] subset: gosubset_prok is_a: GO:0046678 ! response to bacteriocin is_a: GO:0071236 ! cellular response to antibiotic [Term] id: GO:0071238 name: cellular response to brefeldin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah] is_a: GO:0031001 ! response to brefeldin A is_a: GO:0071236 ! cellular response to antibiotic [Term] id: GO:0071239 name: cellular response to streptomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:mah] is_a: GO:0046679 ! response to streptomycin is_a: GO:0071236 ! cellular response to antibiotic [Term] id: GO:0071240 name: cellular response to food namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:mah] is_a: GO:0032094 ! response to food is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0071241 name: cellular response to inorganic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0010035 ! response to inorganic substance is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0071242 name: cellular response to ammonium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:mah] is_a: GO:0060359 ! response to ammonium ion is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071243 name: cellular response to arsenic-containing substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah] subset: gosubset_prok synonym: "cellular response to arsenic" EXACT [GOC:curators] is_a: GO:0046685 ! response to arsenic-containing substance is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071244 name: cellular response to carbon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah] is_a: GO:0010037 ! response to carbon dioxide is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071245 name: cellular response to carbon monoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:mah] is_a: GO:0034465 ! response to carbon monoxide is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071246 name: cellular response to chlorate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:mah] is_a: GO:0010157 ! response to chlorate is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071247 name: cellular response to chromate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0046687 ! response to chromate is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071248 name: cellular response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to heavy metal" NARROW [GOC:mah] synonym: "cellular response to metal" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071249 name: cellular response to nitrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah] is_a: GO:0010167 ! response to nitrate is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071250 name: cellular response to nitrite namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah] is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0080033 ! response to nitrite [Term] id: GO:0071251 name: cellular response to silicon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:mah] synonym: "cellular response to silica" EXACT [GOC:mah] synonym: "cellular response to silox" EXACT [GOC:mah] is_a: GO:0034021 ! response to silicon dioxide is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071252 name: cellular response to sulfur dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [GOC:mah] is_a: GO:0010477 ! response to sulfur dioxide is_a: GO:0071241 ! cellular response to inorganic substance [Term] id: GO:0071253 name: connexin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions." [GOC:mah, PMID:19864490] is_a: GO:0005515 ! protein binding [Term] id: GO:0071254 name: cytoplasmic U snRNP body namespace: cellular_component def: "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295] synonym: "U body" EXACT [GOC:sart, PMID:17595295] synonym: "U-body" EXACT [GOc:mah] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0071255 name: CVT vesicle assembly namespace: biological_process def: "A vesicle organization process that takes place as part of the CVT pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI)." [GOC:rb, PMID:10966461, PMID:11085977] synonym: "CVT vesicle biosynthesis" RELATED [GOC:mah] synonym: "CVT vesicle formation" EXACT [GOC:mah] is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0032258 ! CVT pathway [Term] id: GO:0071256 name: translocon complex namespace: cellular_component alt_id: GO:0031206 def: "A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins." [GOC:mah, PMID:10611978, PMID:18166647, PMID:8612571] synonym: "Sec complex-associated translocon complex" NARROW [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane [Term] id: GO:0071257 name: cellular response to electrical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:mah] synonym: "cellular response to electricity" RELATED [GOC:mah] is_a: GO:0051602 ! response to electrical stimulus is_a: GO:0071214 ! cellular response to abiotic stimulus [Term] id: GO:0071258 name: cellular response to gravity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:mah] synonym: "cellular response to gravitational stimulus" EXACT [GOC:mah] is_a: GO:0009629 ! response to gravity is_a: GO:0071214 ! cellular response to abiotic stimulus [Term] id: GO:0071259 name: cellular response to magnetism namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:mah] synonym: "cellular response to magnetic stimulus" EXACT [GOC:mah] is_a: GO:0071000 ! response to magnetism is_a: GO:0071214 ! cellular response to abiotic stimulus [Term] id: GO:0071260 name: cellular response to mechanical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:mah] synonym: "cellular mechanical stimulus response" EXACT [GOC:mah] is_a: GO:0009612 ! response to mechanical stimulus is_a: GO:0071214 ! cellular response to abiotic stimulus is_a: GO:0071496 ! cellular response to external stimulus [Term] id: GO:0071261 name: Ssh1 translocon complex namespace: cellular_component def: "A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences." [GOC:mah, PMID:12134063, PMID:8612571] synonym: "Ssh1p-Sss1p-Sbh2p complex" NARROW [GOC:mah] is_a: GO:0071256 ! translocon complex [Term] id: GO:0071262 name: regulation of translational initiation in response to starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah] synonym: "regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0043558 ! regulation of translational initiation in response to stress [Term] id: GO:0071263 name: negative regulation of translational initiation in response to starvation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment." [GOC:mah] synonym: "down regulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "down-regulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "downregulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "inhibition of translation initiation in response to starvation" NARROW [GOC:mah] synonym: "negative regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw] is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:0071262 ! regulation of translational initiation in response to starvation [Term] id: GO:0071264 name: positive regulation of translational initiation in response to starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah] synonym: "activation of translation initiation in response to starvation" NARROW [GOC:mah] synonym: "positive regulation of translational initiation in response to nutrient starvation" EXACT [GOC:mah] synonym: "stimulation of translation initiation in response to starvation" NARROW [GOC:mah] synonym: "up regulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "up-regulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "upregulation of translation initiation in response to starvation" EXACT [GOC:mah] is_a: GO:0032058 ! positive regulation of translational initiation in response to stress is_a: GO:0071262 ! regulation of translational initiation in response to starvation [Term] id: GO:0071265 name: L-methionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid." [CHEBI:16643, GOC:ecd] synonym: "L-methionine anabolism" EXACT [GOC:mah] synonym: "L-methionine biosynthesis" EXACT [GOC:mah] synonym: "L-methionine formation" EXACT [GOC:mah] synonym: "L-methionine synthesis" EXACT [GOC:mah] is_a: GO:0009086 ! methionine biosynthetic process [Term] id: GO:0071266 name: 'de novo' L-methionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components." [CHEBI:16643, GOC:ecd] synonym: "'de novo' L-methionine anabolism" EXACT [GOC:mah] synonym: "'de novo' L-methionine biosynthesis" EXACT [GOC:mah] synonym: "'de novo' L-methionine formation" EXACT [GOC:mah] synonym: "'de novo' L-methionine synthesis" EXACT [GOC:mah] is_a: GO:0071265 ! L-methionine biosynthetic process [Term] id: GO:0071267 name: L-methionine salvage namespace: biological_process def: "Any process that generates L-methionine from derivatives of it, without de novo synthesis." [CHEBI:16643, GOC:ecd] is_a: GO:0071265 ! L-methionine biosynthetic process [Term] id: GO:0071268 name: homocysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid." [CHEBI:17230, GOC:ecd, GOC:mah] synonym: "homocysteine anabolism" EXACT [GOC:mah] synonym: "homocysteine biosynthesis" EXACT [GOC:mah] synonym: "homocysteine formation" EXACT [GOC:mah] synonym: "homocysteine synthesis" EXACT [GOC:mah] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0050667 ! homocysteine metabolic process [Term] id: GO:0071269 name: L-homocysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-homocysteine, the L-enantiomer of 2-amino-4-sulfanylbutanoic acid." [CHEBI:17588, GOC:ecd, GOC:mah] synonym: "L-homocysteine anabolism" EXACT [GOC:mah] synonym: "L-homocysteine biosynthesis" EXACT [GOC:mah] synonym: "L-homocysteine formation" EXACT [GOC:mah] synonym: "L-homocysteine synthesis" EXACT [GOC:mah] is_a: GO:0071268 ! homocysteine biosynthetic process [Term] id: GO:0071270 name: 1-butanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-butanol, an alkyl primary alcohol with the formula C4H10O." [CHEBI:28885, GOC:ecd, GOC:mah] synonym: "1-butanol metabolism" EXACT [GOC:mah] synonym: "butan-1-ol metabolic process" EXACT [CHEBI:28885] synonym: "butanol metabolic process" BROAD [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0071271 name: 1-butanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O." [CHEBI:28885, GOC:ecd, GOC:mah] synonym: "1-butanol anabolism" EXACT [GOC:mah] synonym: "1-butanol biosynthesis" EXACT [GOC:mah] synonym: "1-butanol formation" EXACT [GOC:mah] synonym: "1-butanol synthesis" EXACT [GOC:mah] synonym: "butan-1-ol biosynthetic process" EXACT [CHEBI:28885] synonym: "butanol biosynthetic process" BROAD [GOC:mah] is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0071270 ! 1-butanol metabolic process [Term] id: GO:0071272 name: morphine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [CHEBI:17303, GOC:mah] subset: gosubset_prok synonym: "morphine metabolism" EXACT [GOC:mah] xref: Wikipedia:Morphine is_a: GO:0033076 ! isoquinoline alkaloid metabolic process [Term] id: GO:0071273 name: morphine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [CHEBI:17303, GOC:ecd, GOC:mah] subset: gosubset_prok synonym: "morphine breakdown" EXACT [GOC:mah] synonym: "morphine catabolism" EXACT [GOC:mah] synonym: "morphine degradation" EXACT [GOC:mah] xref: UniPathway:Q02198 is_a: GO:0071272 ! morphine metabolic process is_a: GO:0071274 ! isoquinoline alkaloid catabolic process [Term] id: GO:0071274 name: isoquinoline alkaloid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] subset: gosubset_prok synonym: "ipecac alkaloid catabolism" RELATED [GOC:mah] synonym: "isoquinoline alkaloid breakdown" EXACT [GOC:mah] synonym: "isoquinoline alkaloid catabolism" EXACT [GOC:mah] synonym: "isoquinoline alkaloid degradation" EXACT [GOC:mah] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0033076 ! isoquinoline alkaloid metabolic process [Term] id: GO:0071275 name: cellular response to aluminum ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:mah] synonym: "cellular response to aluminium ion" EXACT [GOC:mah] synonym: "cellular response to aluminum" EXACT [GOC:mah] is_a: GO:0010044 ! response to aluminum ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071276 name: cellular response to cadmium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to cadmium" EXACT [GOC:mah] is_a: GO:0046686 ! response to cadmium ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071277 name: cellular response to calcium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah] synonym: "cellular response to Ca2+ ion" EXACT [GOC:mah] is_a: GO:0051592 ! response to calcium ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071278 name: cellular response to cesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:mah] synonym: "cellular response to cesium" EXACT [GOC:mah] is_a: GO:0010164 ! response to cesium ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071279 name: cellular response to cobalt ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah] is_a: GO:0032025 ! response to cobalt ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071280 name: cellular response to copper ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to copper" EXACT [GOC:mah] is_a: GO:0046688 ! response to copper ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071281 name: cellular response to iron ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:mah] synonym: "cellular response to iron" EXACT [GOC:mah] is_a: GO:0010039 ! response to iron ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071282 name: cellular response to iron(II) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:mah] synonym: "cellular response to iron(II)" EXACT [GOC:mah] is_a: GO:0010040 ! response to iron(II) ion is_a: GO:0071281 ! cellular response to iron ion [Term] id: GO:0071283 name: cellular response to iron(III) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:mah] synonym: "cellular response to iron(III)" EXACT [GOC:mah] is_a: GO:0010041 ! response to iron(III) ion is_a: GO:0071281 ! cellular response to iron ion [Term] id: GO:0071284 name: cellular response to lead ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:mah] is_a: GO:0010288 ! response to lead ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071285 name: cellular response to lithium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:mah] is_a: GO:0010226 ! response to lithium ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071286 name: cellular response to magnesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah] is_a: GO:0032026 ! response to magnesium ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071287 name: cellular response to manganese ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:mah] synonym: "cellular response to manganese" EXACT [GOC:mah] is_a: GO:0010042 ! response to manganese ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071288 name: cellular response to mercury ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to mercuric ion" EXACT [GOC:mah] synonym: "cellular response to mercury" EXACT [GOC:mah] is_a: GO:0046689 ! response to mercury ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071289 name: cellular response to nickel ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:mah] synonym: "cellular response to nickel" EXACT [GOC:mah] is_a: GO:0010045 ! response to nickel ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071290 name: cellular response to platinum ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:mah] synonym: "cellular response to platinum" EXACT [GOc:mah] is_a: GO:0070541 ! response to platinum ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071291 name: cellular response to selenium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mah] is_a: GO:0010269 ! response to selenium ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071292 name: cellular response to silver ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [GOC:mah] is_a: GO:0010272 ! response to silver ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071293 name: cellular response to tellurium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to tellurium" EXACT [GOC:mah] is_a: GO:0046690 ! response to tellurium ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071294 name: cellular response to zinc ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:mah] synonym: "cellular response to zinc" EXACT [GOC:mah] is_a: GO:0010043 ! response to zinc ion is_a: GO:0071248 ! cellular response to metal ion [Term] id: GO:0071295 name: cellular response to vitamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:mah] is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0033273 ! response to vitamin [Term] id: GO:0071296 name: cellular response to biotin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:mah] synonym: "cellular response to Bios IIB" EXACT [GOC:sl] synonym: "cellular response to coenzyme R" EXACT [GOC:sl] synonym: "cellular response to vitamin B7" EXACT [GOC:sl] synonym: "cellular response to vitamin H" EXACT [GOC:sl] is_a: GO:0070781 ! response to biotin is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071297 name: cellular response to cobalamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:mah] synonym: "cellular response to vitamin B12" EXACT [GOC:mah] is_a: GO:0033590 ! response to cobalamin is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071298 name: cellular response to L-ascorbic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:mah] synonym: "cellular response to ascorbic acid" BROAD [GOC:mah] synonym: "cellular response to L-ascorbate" EXACT [GOC:mah] synonym: "cellular response to vitamin C" EXACT [GOC:mah] is_a: GO:0033591 ! response to L-ascorbic acid is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071299 name: cellular response to vitamin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:mah] synonym: "cellular response to retinol" NARROW [GOC:mah] is_a: GO:0033189 ! response to vitamin A is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071300 name: cellular response to retinoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:mah] synonym: "cellular response to vitamin A acid" EXACT [GOC:mah] is_a: GO:0032526 ! response to retinoic acid is_a: GO:0071299 ! cellular response to vitamin A [Term] id: GO:0071301 name: cellular response to vitamin B1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:mah] synonym: "cellular response to thiamin" EXACT [GOC:mah] synonym: "cellular response to thiamine" EXACT [GOC:mah] is_a: GO:0010266 ! response to vitamin B1 is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071302 name: cellular response to vitamin B2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:mah] synonym: "cellular response to riboflavin" EXACT [GOC:mah] is_a: GO:0033274 ! response to vitamin B2 is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071303 name: cellular response to vitamin B3 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:mah] synonym: "cellular response to niacin" NARROW [GOC:mah] synonym: "cellular response to nicotinamide" NARROW [GOC:mah] is_a: GO:0033552 ! response to vitamin B3 is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071304 name: cellular response to vitamin B6 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah] is_a: GO:0034516 ! response to vitamin B6 is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071305 name: cellular response to vitamin D namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:mah] synonym: "cellular response to calciferol" EXACT [GOC:mah] synonym: "cellular response to cholecalciferol" NARROW [GOC:mah] synonym: "cellular response to ergocalciferol" NARROW [GOC:mah] is_a: GO:0033280 ! response to vitamin D is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071306 name: cellular response to vitamin E namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:mah] synonym: "cellular response to DL-alpha-tocopherol acetate" NARROW [GOC:mah] synonym: "cellular response to DL-alpha-tocopheryl acetate" NARROW [GOC:mah] synonym: "cellular response to O-Acetyl-alpha-tocopherol" NARROW [GOC:mah] is_a: GO:0033197 ! response to vitamin E is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071307 name: cellular response to vitamin K namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:mah] is_a: GO:0032571 ! response to vitamin K is_a: GO:0071295 ! cellular response to vitamin [Term] id: GO:0071308 name: cellular response to menaquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:mah] synonym: "cellular response to menatetrenone" EXACT [GOC:mah] synonym: "cellular response to vitamin K2" EXACT [GOC:mah] is_a: GO:0032572 ! response to menaquinone is_a: GO:0071307 ! cellular response to vitamin K [Term] id: GO:0071309 name: cellular response to phylloquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:mah] synonym: "cellular response to vitamin K1" EXACT [GOC:mah] is_a: GO:0032573 ! response to phylloquinone is_a: GO:0071307 ! cellular response to vitamin K [Term] id: GO:0071310 name: cellular response to organic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0010033 ! response to organic substance is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0071311 name: cellular response to acetate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0010034 ! response to acetate is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071312 name: cellular response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:mah] is_a: GO:0043279 ! response to alkaloid is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071313 name: cellular response to caffeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:mah] is_a: GO:0031000 ! response to caffeine is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071415 ! cellular response to purine-containing compound [Term] id: GO:0071314 name: cellular response to cocaine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:mah] is_a: GO:0042220 ! response to cocaine is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071416 ! cellular response to tropane [Term] id: GO:0071315 name: cellular response to morphine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:mah] is_a: GO:0043278 ! response to morphine is_a: GO:0071317 ! cellular response to isoquinoline alkaloid [Term] id: GO:0071316 name: cellular response to nicotine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:mah] is_a: GO:0035094 ! response to nicotine is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071317 name: cellular response to isoquinoline alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:mah] is_a: GO:0014072 ! response to isoquinoline alkaloid is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071318 name: cellular response to ATP namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:mah] synonym: "cellular response to adenosine 5'-triphosphate" EXACT [GOC:mah] synonym: "cellular response to adenosine triphosphate" EXACT [GOC:mah] is_a: GO:0033198 ! response to ATP is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071319 name: cellular response to benzoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [GOC:mah] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0080021 ! response to benzoic acid stimulus [Term] id: GO:0071320 name: cellular response to cAMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah] synonym: "cellular response to 3',5' cAMP" EXACT [GOC:mah] synonym: "cellular response to 3',5'-cAMP" EXACT [GOC:mah] synonym: "cellular response to adenosine 3',5'-cyclophosphate" EXACT [GOC:mah] synonym: "cellular response to cyclic AMP" EXACT [GOC:mah] is_a: GO:0051591 ! response to cAMP is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071321 name: cellular response to cGMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:mah] synonym: "cellular response to 3',5' cGMP" EXACT [GOC:mah] synonym: "cellular response to 3',5'-cGMP" EXACT [GOC:mah] synonym: "cellular response to cyclic GMP" EXACT [GOC:mah] synonym: "cellular response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah] is_a: GO:0070305 ! response to cGMP is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071322 name: cellular response to carbohydrate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah] is_a: GO:0009743 ! response to carbohydrate stimulus is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071323 name: cellular response to chitin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:mah] is_a: GO:0010200 ! response to chitin is_a: GO:0071322 ! cellular response to carbohydrate stimulus [Term] id: GO:0071324 name: cellular response to disaccharide stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:mah] is_a: GO:0034285 ! response to disaccharide stimulus is_a: GO:0071322 ! cellular response to carbohydrate stimulus [Term] id: GO:0071325 name: cellular response to mannitol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah] is_a: GO:0010555 ! response to mannitol stimulus is_a: GO:0071322 ! cellular response to carbohydrate stimulus [Term] id: GO:0071326 name: cellular response to monosaccharide stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] is_a: GO:0034284 ! response to monosaccharide stimulus is_a: GO:0071322 ! cellular response to carbohydrate stimulus [Term] id: GO:0071327 name: cellular response to trehalose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [GOC:mah] is_a: GO:0010353 ! response to trehalose stimulus is_a: GO:0071324 ! cellular response to disaccharide stimulus [Term] id: GO:0071328 name: cellular response to maltose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:mah] is_a: GO:0034286 ! response to maltose stimulus is_a: GO:0071324 ! cellular response to disaccharide stimulus [Term] id: GO:0071329 name: cellular response to sucrose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah] is_a: GO:0009744 ! response to sucrose stimulus is_a: GO:0071324 ! cellular response to disaccharide stimulus [Term] id: GO:0071330 name: cellular response to trehalose-6-phosphate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [GOC:mah] is_a: GO:0071324 ! cellular response to disaccharide stimulus is_a: GO:0080094 ! response to trehalose-6-phosphate stimulus [Term] id: GO:0071331 name: cellular response to hexose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah] is_a: GO:0009746 ! response to hexose stimulus is_a: GO:0071326 ! cellular response to monosaccharide stimulus [Term] id: GO:0071332 name: cellular response to fructose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah] is_a: GO:0009750 ! response to fructose stimulus is_a: GO:0071331 ! cellular response to hexose stimulus [Term] id: GO:0071333 name: cellular response to glucose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah] is_a: GO:0001678 ! cellular glucose homeostasis is_a: GO:0009749 ! response to glucose stimulus is_a: GO:0071331 ! cellular response to hexose stimulus [Term] id: GO:0071334 name: cellular response to rhamnose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mah] synonym: "cellular response to L-rhamnose stimulus" NARROW [GOC:mah] is_a: GO:0032149 ! response to rhamnose stimulus is_a: GO:0071331 ! cellular response to hexose stimulus [Term] id: GO:0071335 name: hair follicle cell proliferation namespace: biological_process def: "The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population." [GOC:rph, PMID:16086254] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0071336 name: regulation of hair follicle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hair follicle cell proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0071335 ! hair follicle cell proliferation [Term] id: GO:0071337 name: negative regulation of hair follicle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of hair follicle cell proliferation." [GOC:mah] synonym: "down regulation of hair follicle cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of hair follicle cell proliferation" EXACT [GOC:mah] synonym: "downregulation of hair follicle cell proliferation" EXACT [GOc:mah] synonym: "inhibition of hair follicle cell proliferation" NARROW [GOC:mah] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0071336 ! regulation of hair follicle cell proliferation relationship: negatively_regulates GO:0071335 ! hair follicle cell proliferation [Term] id: GO:0071338 name: positive regulation of hair follicle cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of hair follicle cell proliferation." [GOC:mah] synonym: "activation of hair follicle cell proliferation" NARROW [GOC:mah] synonym: "stimulation of hair follicle cell proliferation" NARROW [GOC:mah] synonym: "up regulation of hair follicle cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of hair follicle cell proliferation" EXACT [GOC:mah] synonym: "upregulation of hair follicle cell proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0071336 ! regulation of hair follicle cell proliferation relationship: positively_regulates GO:0071335 ! hair follicle cell proliferation [Term] id: GO:0071339 name: MLL1 complex namespace: cellular_component def: "A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5." [GOC:sp, PMID:15960975] is_a: GO:0035097 ! histone methyltransferase complex [Term] id: GO:0071340 name: skeletal muscle nicotinic acetylcholine receptor clustering namespace: biological_process def: "The accumulation of acetylcholine receptors (AChRs) in a narrow, central region of muscle fibers, in apposition to nerve terminals." [GOC:dsf, PMID:19285469] synonym: "skeletal muscle AChR clustering" EXACT [GOC:mah] is_a: GO:0001941 ! postsynaptic membrane organization is_a: GO:0043113 ! receptor clustering relationship: part_of GO:0007528 ! neuromuscular junction development [Term] id: GO:0071341 name: medial cortical node namespace: cellular_component def: "A protein complex that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis." [GOC:mah, GOC:vw, PMID:19474789, PMID:19959363] synonym: "mid1p medial cortical dot" EXACT [GOC:vw] synonym: "midsome" EXACT [GOC:vw, PMID:19959363] is_a: GO:0032155 ! cell division site part is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0031097 ! medial cortex [Term] id: GO:0071342 name: regulation of establishment of contractile ring localization involved in cell cycle cytokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location that contributes to cytokinesis during cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0060341 ! regulation of cellular localization is_a: GO:2000073 ! regulation of site selection involved in cell cycle cytokinesis relationship: regulates GO:0032188 ! establishment of contractile ring localization involved in cell cycle cytokinesis [Term] id: GO:0071343 name: negative regulation of establishment of contractile ring localization involved in cell cycle cytokinesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location." [GOC:mah] synonym: "negative regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "negative regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0071342 ! regulation of establishment of contractile ring localization involved in cell cycle cytokinesis is_a: GO:0071776 ! negative regulation of cell cycle cytokinesis relationship: negatively_regulates GO:0032188 ! establishment of contractile ring localization involved in cell cycle cytokinesis [Term] id: GO:0071344 name: diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid." [CHEBI:35782, GOC:pde] subset: gosubset_prok synonym: "pyrophosphate metabolism" EXACT [GOC:mah] xref: Reactome:1252964 "Pyrophosphate hydrolysis" xref: Reactome:1279894 "Pyrophosphate hydrolysis" xref: Reactome:1298805 "Pyrophosphate hydrolysis" xref: Reactome:1326467 "Pyrophosphate hydrolysis" xref: Reactome:1352581 "Pyrophosphate hydrolysis" xref: Reactome:1372809 "Pyrophosphate hydrolysis" xref: Reactome:1392821 "Pyrophosphate hydrolysis" xref: Reactome:1417294 "Pyrophosphate hydrolysis" xref: Reactome:1450384 "Pyrophosphate hydrolysis" xref: Reactome:1470911 "Pyrophosphate hydrolysis" xref: Reactome:1482951 "Pyrophosphate hydrolysis" xref: Reactome:1520951 "Pyrophosphate hydrolysis" xref: Reactome:1526701 "Pyrophosphate hydrolysis" xref: Reactome:1532427 "Pyrophosphate hydrolysis" xref: Reactome:71737 "Pyrophosphate hydrolysis" is_a: GO:0006796 ! phosphate metabolic process [Term] id: GO:0071345 name: cellular response to cytokine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] is_a: GO:0034097 ! response to cytokine stimulus is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071346 name: cellular response to interferon-gamma namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon." [GOC:mah] synonym: "cellular response to gamma-interferon" RELATED [GOC:mah] synonym: "cellular response to immune interferon" EXACT [GOC:mah] synonym: "cellular response to type II IFN" EXACT [GOC:mah] synonym: "cellular response to type II interferon" EXACT [GOC:mah] is_a: GO:0034341 ! response to interferon-gamma is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071347 name: cellular response to interleukin-1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:mah] synonym: "cellular response to IL-1" EXACT [GOC:mah] is_a: GO:0070555 ! response to interleukin-1 is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071348 name: cellular response to interleukin-11 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah] synonym: "cellular response to IL-11" EXACT [GOC:mah] is_a: GO:0071105 ! response to interleukin-11 is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071349 name: cellular response to interleukin-12 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah] synonym: "cellular response to IL-12" EXACT [GOC:mah] is_a: GO:0070671 ! response to interleukin-12 is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071350 name: cellular response to interleukin-15 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah] synonym: "cellular response to IL-15" EXACT [GOC:mah] is_a: GO:0070672 ! response to interleukin-15 is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071351 name: cellular response to interleukin-18 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah] synonym: "cellular response to IL-18" EXACT [GOC:mah] is_a: GO:0070673 ! response to interleukin-18 is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071352 name: cellular response to interleukin-2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah] synonym: "cellular response to IL-2" EXACT [GOC:mah] is_a: GO:0070669 ! response to interleukin-2 is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071353 name: cellular response to interleukin-4 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah] synonym: "cellular response to IL-4" EXACT [GOC:mah] is_a: GO:0070670 ! response to interleukin-4 is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071354 name: cellular response to interleukin-6 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] synonym: "cellular response to IL-6" EXACT [GOC:mah] is_a: GO:0070741 ! response to interleukin-6 is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071355 name: cellular response to interleukin-9 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah] synonym: "cellular response to IL-9" EXACT [GOC:mah] is_a: GO:0071104 ! response to interleukin-9 is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071356 name: cellular response to tumor necrosis factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] synonym: "cellular response to TNF" EXACT [GOC:mah] is_a: GO:0034612 ! response to tumor necrosis factor is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071357 name: cellular response to type I interferon namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah] synonym: "cellular response to type I IFN" EXACT [GOC:mah] is_a: GO:0034340 ! response to type I interferon is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071358 name: cellular response to type III interferon namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Type III interferons are members of the interferon-lambda gene family." [GOC:mah] synonym: "cellular response to interferon-lambda" EXACT [GOC:mah] synonym: "cellular response to type III IFN" EXACT [GOC:mah] is_a: GO:0034342 ! response to type III interferon is_a: GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0071359 name: cellular response to dsRNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:mah] synonym: "cellular response to double-stranded RNA" EXACT [GOC:mah] is_a: GO:0043331 ! response to dsRNA is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071360 name: cellular response to exogenous dsRNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:mah] synonym: "cellular response to exogenous double-stranded RNA" EXACT [GOC:mah] synonym: "cellular response to viral dsRNA" NARROW [GOC:mah] is_a: GO:0043330 ! response to exogenous dsRNA is_a: GO:0071359 ! cellular response to dsRNA [Term] id: GO:0071361 name: cellular response to ethanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah] is_a: GO:0045471 ! response to ethanol is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071362 name: cellular response to ether namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:mah] is_a: GO:0045472 ! response to ether [Term] id: GO:0071363 name: cellular response to growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] is_a: GO:0070848 ! response to growth factor stimulus is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071364 name: cellular response to epidermal growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah] synonym: "cellular response to EGF stimulus" EXACT [GOC:mah] is_a: GO:0070849 ! response to epidermal growth factor stimulus is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0071365 name: cellular response to auxin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:mah] is_a: GO:0009733 ! response to auxin stimulus is_a: GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0071366 name: cellular response to indolebutyric acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [GOC:mah] synonym: "cellular response to IBA stimulus" EXACT [GOC:mah] synonym: "cellular response to indole-3-butyric acid stimulus" NARROW [GOC:mah] is_a: GO:0071365 ! cellular response to auxin stimulus is_a: GO:0080026 ! response to indolebutyric acid stimulus [Term] id: GO:0071367 name: cellular response to brassinosteroid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:mah] is_a: GO:0009741 ! response to brassinosteroid stimulus is_a: GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0071368 name: cellular response to cytokinin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:mah] is_a: GO:0009735 ! response to cytokinin stimulus is_a: GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0071369 name: cellular response to ethylene stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:mah] synonym: "cellular response to ethene stimulus" EXACT [GOC:mah] is_a: GO:0009723 ! response to ethylene stimulus is_a: GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0071370 name: cellular response to gibberellin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:mah] synonym: "cellular response to gibberellic acid stimulus" NARROW [GOC:mah] is_a: GO:0009739 ! response to gibberellin stimulus is_a: GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0071371 name: cellular response to gonadotropin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0034698 ! response to gonadotropin stimulus [Term] id: GO:0071372 name: cellular response to follicle-stimulating hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah] synonym: "cellular response to follicle stimulating hormone stimulus" EXACT [] synonym: "cellular response to FSH stimulus" EXACT [] is_a: GO:0032354 ! response to follicle-stimulating hormone stimulus is_a: GO:0071371 ! cellular response to gonadotropin stimulus [Term] id: GO:0071373 name: cellular response to luteinizing hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:mah] is_a: GO:0034699 ! response to luteinizing hormone stimulus is_a: GO:0071371 ! cellular response to gonadotropin stimulus [Term] id: GO:0071374 name: cellular response to parathyroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071107 ! response to parathyroid hormone stimulus [Term] id: GO:0071375 name: cellular response to peptide hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0043434 ! response to peptide hormone stimulus [Term] id: GO:0071376 name: cellular response to corticotropin-releasing hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [GOC:mah] synonym: "cellular response to corticoliberin stimulus" EXACT [GOC:mah] synonym: "cellular response to corticotropin-releasing factor stimulus" EXACT [GOC:mah] synonym: "cellular response to CRF stimulus" EXACT [GOC:mah] synonym: "cellular response to CRH stimulus" EXACT [GOC:mah] is_a: GO:0043435 ! response to corticotropin-releasing hormone stimulus is_a: GO:0071375 ! cellular response to peptide hormone stimulus [Term] id: GO:0071377 name: cellular response to glucagon stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:mah] xref: Reactome:1253201 "Glucagon signaling in metabolic regulation" xref: Reactome:1280135 "Glucagon signaling in metabolic regulation" xref: Reactome:1299015 "Glucagon signaling in metabolic regulation" xref: Reactome:1326707 "Glucagon signaling in metabolic regulation" xref: Reactome:1352819 "Glucagon signaling in metabolic regulation" xref: Reactome:1373028 "Glucagon signaling in metabolic regulation" xref: Reactome:1393045 "Glucagon signaling in metabolic regulation" xref: Reactome:1417521 "Glucagon signaling in metabolic regulation" xref: Reactome:1450617 "Glucagon signaling in metabolic regulation" xref: Reactome:1471119 "Glucagon signaling in metabolic regulation" xref: Reactome:1483185 "Glucagon signaling in metabolic regulation" xref: Reactome:1521079 "Glucagon signaling in metabolic regulation" xref: Reactome:1526857 "Glucagon signaling in metabolic regulation" xref: Reactome:1532584 "Glucagon signaling in metabolic regulation" xref: Reactome:163359 "Glucagon signaling in metabolic regulation" is_a: GO:0033762 ! response to glucagon stimulus is_a: GO:0071375 ! cellular response to peptide hormone stimulus [Term] id: GO:0071378 name: cellular response to growth hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:mah] is_a: GO:0060416 ! response to growth hormone stimulus is_a: GO:0071375 ! cellular response to peptide hormone stimulus [Term] id: GO:0071379 name: cellular response to prostaglandin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0034694 ! response to prostaglandin stimulus is_a: GO:0071396 ! cellular response to lipid [Term] id: GO:0071380 name: cellular response to prostaglandin E stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:mah] is_a: GO:0034695 ! response to prostaglandin E stimulus is_a: GO:0071379 ! cellular response to prostaglandin stimulus [Term] id: GO:0071381 name: cellular response to prostaglandin F stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:mah] is_a: GO:0034696 ! response to prostaglandin F stimulus is_a: GO:0071379 ! cellular response to prostaglandin stimulus [Term] id: GO:0071382 name: cellular response to prostaglandin I stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:mah] is_a: GO:0034697 ! response to prostaglandin I stimulus is_a: GO:0071379 ! cellular response to prostaglandin stimulus [Term] id: GO:0071383 name: cellular response to steroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0048545 ! response to steroid hormone stimulus [Term] id: GO:0071384 name: cellular response to corticosteroid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah] is_a: GO:0031960 ! response to corticosteroid stimulus is_a: GO:0071383 ! cellular response to steroid hormone stimulus [Term] id: GO:0071385 name: cellular response to glucocorticoid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:mah] is_a: GO:0051384 ! response to glucocorticoid stimulus is_a: GO:0071384 ! cellular response to corticosteroid stimulus [Term] id: GO:0071386 name: cellular response to corticosterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [GOC:mah] is_a: GO:0051412 ! response to corticosterone stimulus is_a: GO:0071385 ! cellular response to glucocorticoid stimulus is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus [Term] id: GO:0071387 name: cellular response to cortisol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [GOC:mah] synonym: "cellular response to hydrocortisone stimulus" EXACT [GOC:mah] is_a: GO:0051414 ! response to cortisol stimulus is_a: GO:0071385 ! cellular response to glucocorticoid stimulus [Term] id: GO:0071388 name: cellular response to cortisone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [GOC:mah] is_a: GO:0051413 ! response to cortisone stimulus is_a: GO:0071385 ! cellular response to glucocorticoid stimulus [Term] id: GO:0071389 name: cellular response to mineralocorticoid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:mah] is_a: GO:0051385 ! response to mineralocorticoid stimulus is_a: GO:0071384 ! cellular response to corticosteroid stimulus [Term] id: GO:0071390 name: cellular response to ecdysone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah] is_a: GO:0035075 ! response to ecdysone is_a: GO:0071383 ! cellular response to steroid hormone stimulus [Term] id: GO:0071391 name: cellular response to estrogen stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:mah] synonym: "cellular response to oestrogen stimulus" EXACT [GOC:mah] is_a: GO:0043627 ! response to estrogen stimulus is_a: GO:0071383 ! cellular response to steroid hormone stimulus [Term] id: GO:0071392 name: cellular response to estradiol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah] synonym: "cellular response to E2 stimulus" EXACT [GOC:mah] is_a: GO:0032355 ! response to estradiol stimulus is_a: GO:0071391 ! cellular response to estrogen stimulus [Term] id: GO:0071393 name: cellular response to progesterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:mah] is_a: GO:0032570 ! response to progesterone stimulus is_a: GO:0071383 ! cellular response to steroid hormone stimulus [Term] id: GO:0071394 name: cellular response to testosterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:mah] is_a: GO:0033574 ! response to testosterone stimulus is_a: GO:0071383 ! cellular response to steroid hormone stimulus [Term] id: GO:0071395 name: cellular response to jasmonic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:mah] is_a: GO:0009753 ! response to jasmonic acid stimulus is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0071396 name: cellular response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] is_a: GO:0033993 ! response to lipid is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071397 name: cellular response to cholesterol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:mah] is_a: GO:0070723 ! response to cholesterol is_a: GO:0071396 ! cellular response to lipid [Term] id: GO:0071398 name: cellular response to fatty acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:mah] is_a: GO:0070542 ! response to fatty acid is_a: GO:0071396 ! cellular response to lipid [Term] id: GO:0071399 name: cellular response to linoleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [GOC:mah] synonym: "cellular response to linoleate" EXACT [GOC:mah] is_a: GO:0070543 ! response to linoleic acid is_a: GO:0071398 ! cellular response to fatty acid [Term] id: GO:0071400 name: cellular response to oleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [GOC:mah] synonym: "cellular response to oleate" EXACT [GOC:mah] is_a: GO:0034201 ! response to oleic acid is_a: GO:0071398 ! cellular response to fatty acid [Term] id: GO:0071401 name: cellular response to triglyceride namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:mah] synonym: "cellular response to triacylglyceride" EXACT [GOC:mah] synonym: "cellular response to triacylglycerol" EXACT [GOC:mah] is_a: GO:0034014 ! response to triglyceride is_a: GO:0071396 ! cellular response to lipid [Term] id: GO:0071402 name: cellular response to lipoprotein particle stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:mah] is_a: GO:0055094 ! response to lipoprotein stimulus is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0071403 name: cellular response to high density lipoprotein particle stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus." [GOC:mah] is_a: GO:0055099 ! response to high density lipoprotein particle stimulus is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus [Term] id: GO:0071404 name: cellular response to low-density lipoprotein particle stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus." [GOC:mah] is_a: GO:0055098 ! response to low-density lipoprotein particle stimulus is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus [Term] id: GO:0071405 name: cellular response to methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:mah] is_a: GO:0033986 ! response to methanol is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071406 name: cellular response to methylmercury namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:mah] synonym: "cellular response to CH3-Hg+" EXACT [GOC:mah] synonym: "cellular response to MeHg+" EXACT [GOC:mah] is_a: GO:0051597 ! response to methylmercury is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071407 name: cellular response to organic cyclic compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah] synonym: "cellular response to organic cyclic substance" EXACT [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071408 name: cellular response to cycloalkane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [GOC:mah] is_a: GO:0014071 ! response to cycloalkane is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071409 name: cellular response to cycloheximide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:mah] synonym: "cellular response to actidione" EXACT [GOC:mah] is_a: GO:0046898 ! response to cycloheximide is_a: GO:0071408 ! cellular response to cycloalkane [Term] id: GO:0071410 name: cellular response to cyclopentenone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [GOC:mah] is_a: GO:0010583 ! response to cyclopentenone is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071411 name: cellular response to fluoxetine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:mah] is_a: GO:0014076 ! response to fluoxetine is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071412 name: cellular response to genistein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah] is_a: GO:0033595 ! response to genistein is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071413 name: cellular response to hydroxyisoflavone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [GOC:mah] is_a: GO:0033594 ! response to hydroxyisoflavone is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071414 name: cellular response to methotrexate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:mah] is_a: GO:0031427 ! response to methotrexate is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071415 name: cellular response to purine-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [CHEBI:26401, GOC:mah] synonym: "cellular response to purine" RELATED [GOC:curators] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071416 name: cellular response to tropane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [GOC:mah] is_a: GO:0014073 ! response to tropane is_a: GO:0071407 ! cellular response to organic cyclic compound [Term] id: GO:0071417 name: cellular response to organic nitrogen namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic nitrogen stimulus. An organic nitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [GOC:mah] synonym: "cellular response to organonitrogen compound" EXACT [GOC:mah] is_a: GO:0010243 ! response to organic nitrogen is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0071418 name: cellular response to amine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah] is_a: GO:0014075 ! response to amine stimulus is_a: GO:0071417 ! cellular response to organic nitrogen [Term] id: GO:0071419 name: cellular response to amphetamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:mah] is_a: GO:0001975 ! response to amphetamine is_a: GO:0071418 ! cellular response to amine stimulus [Term] id: GO:0071420 name: cellular response to histamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:mah] synonym: "cellular response to histamine stimulus" EXACT [GOC:mah] is_a: GO:0034776 ! response to histamine is_a: GO:0071418 ! cellular response to amine stimulus [Term] id: GO:0071421 name: manganese ion transmembrane transport namespace: biological_process def: "A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "transmembrane manganese transport" EXACT [GOC:mah] is_a: GO:0006828 ! manganese ion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0071422 name: succinate transmembrane transport namespace: biological_process def: "A process in which a succinate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "transmembrane succinate transport" EXACT [GOC:mah] is_a: GO:0015744 ! succinate transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0071423 name: malate transmembrane transport namespace: biological_process def: "A process in which a malate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "transmembrane malate transport" EXACT [GOC:mah] is_a: GO:0015743 ! malate transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0071424 name: rRNA (cytosine-N4-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine." [GOC:imk, PMID:19965768] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity [Term] id: GO:0071425 name: hemopoietic stem cell proliferation namespace: biological_process def: "The expansion of a hemopoietic stem cell population by cell division. A hemopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:mah] synonym: "hematopoietic stem cell proliferation" EXACT [GOC:mah] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0071426 name: ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm." [GOC:mah] synonym: "ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071166 ! ribonucleoprotein complex localization [Term] id: GO:0071427 name: mRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains messenger RNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "mRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "mRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "mRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "mRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus [Term] id: GO:0071428 name: rRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "rRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "rRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "rRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "rRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus [Term] id: GO:0071429 name: snRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains small nuclear RNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "snRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "snRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "snRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "snRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus [Term] id: GO:0071430 name: pre-microRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains pre-microRNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "pre-microRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "pre-microRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "pre-microRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "pre-microRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus [Term] id: GO:0071431 name: tRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains transfer RNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "tRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "tRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "tRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "tRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus [Term] id: GO:0071432 name: peptide mating pheromone maturation involved in conjugation with cellular fusion namespace: biological_process def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion." [GOC:mah] synonym: "a-factor processing (proteolytic)" NARROW [GOC:vw] synonym: "alpha-factor maturation" NARROW [GOC:vw] synonym: "mating-type peptide pheromone maturation involved in conjugation with cellular fusion" EXACT [GOC:mah] synonym: "peptide mating pheromone formation involved in conjugation with cellular fusion" EXACT [GOC:mah] synonym: "peptide mating pheromone processing involved in conjugation with cellular fusion" EXACT [GOC:mah] is_a: GO:0007323 ! peptide pheromone maturation relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0071433 name: cell wall repair namespace: biological_process def: "A process of cell wall organization that results in the restoration of the cell wall following damage." [GOC:mah, GOC:vw] is_a: GO:0007047 ! cellular cell wall organization [Term] id: GO:0071434 name: cell chemotaxis to angiotensin namespace: biological_process def: "The directed movement of a motile cell in response to the presence of angiotensin." [GOC:mah] synonym: "angiotensin mediated chemotaxis" BROAD [GOC:mah] synonym: "angiotensin-mediated cell chemotaxis" EXACT [GOC:mah] is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0071435 name: potassium ion export namespace: biological_process def: "The directed movement of potassium ions out of a cell or organelle." [GOC:mah] synonym: "potassium export" EXACT [GOC:mah] is_a: GO:0071805 ! potassium ion transmembrane transport [Term] id: GO:0071436 name: sodium ion export namespace: biological_process def: "The directed movement of sodium ions out of a cell or organelle." [GOC:mah] synonym: "sodium export" EXACT [GOC:mah] is_a: GO:0035725 ! sodium ion transmembrane transport [Term] id: GO:0071437 name: invadopodium namespace: cellular_component def: "A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate." [GOC:mah, PMID:16651416, PMID:19491051, PMID:19931459] is_a: GO:0042995 ! cell projection [Term] id: GO:0071438 name: invadopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding an invadopodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0071437 ! invadopodium [Term] id: GO:0071439 name: clathrin complex namespace: cellular_component def: "A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411] synonym: "clathrin triskelion" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0030118 ! clathrin coat [Term] id: GO:0071440 name: regulation of histone H3-K14 acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah] synonym: "regulation of histone H3 acetylation at K14" EXACT [GOC:mah] synonym: "regulation of histone H3K14 acetylation" EXACT [GOC:mah] is_a: GO:0035065 ! regulation of histone acetylation relationship: regulates GO:0044154 ! histone H3-K14 acetylation [Term] id: GO:0071441 name: negative regulation of histone H3-K14 acetylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah] synonym: "down regulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "down-regulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "downregulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "inhibition of histone H3-K14 acetylation" NARROW [GOC:mah] synonym: "negative regulation of histone H3 acetylation at K14" EXACT [GOC:mah] synonym: "negative regulation of histone H3K14 acetylation" EXACT [GOC:mah] is_a: GO:0035067 ! negative regulation of histone acetylation is_a: GO:0071440 ! regulation of histone H3-K14 acetylation relationship: negatively_regulates GO:0044154 ! histone H3-K14 acetylation [Term] id: GO:0071442 name: positive regulation of histone H3-K14 acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah] synonym: "activation of histone H3-K14 acetylation" NARROW [GOC:mah] synonym: "positive regulation of histone H3 acetylation at K14" EXACT [GOC:mah] synonym: "positive regulation of histone H3K14 acetylation" EXACT [GOC:mah] synonym: "stimulation of histone H3-K14 acetylation" NARROW [GOC:mah] synonym: "up regulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "up-regulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "upregulation of histone H3-K14 acetylation" EXACT [GOC:mah] is_a: GO:0035066 ! positive regulation of histone acetylation is_a: GO:0071440 ! regulation of histone H3-K14 acetylation relationship: positively_regulates GO:0044154 ! histone H3-K14 acetylation [Term] id: GO:0071443 name: tDNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA sequences encoding transfer RNA." [GOC:mah] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0071444 name: cellular response to pheromone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular pheromone response" EXACT [GOC:mah] is_a: GO:0019236 ! response to pheromone is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071445 name: cellular response to protein stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0051789 ! response to protein stimulus is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071446 name: cellular response to salicylic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:mah] is_a: GO:0009751 ! response to salicylic acid stimulus is_a: GO:0071310 ! cellular response to organic substance [Term] id: GO:0071447 name: cellular response to hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [GOC:mah] subset: gosubset_prok is_a: GO:0033194 ! response to hydroperoxide is_a: GO:0034599 ! cellular response to oxidative stress [Term] id: GO:0071448 name: cellular response to alkyl hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [GOC:mah] is_a: GO:0033195 ! response to alkyl hydroperoxide is_a: GO:0071447 ! cellular response to hydroperoxide [Term] id: GO:0071449 name: cellular response to lipid hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:mah] subset: gosubset_prok synonym: "cellular response to LHPO" EXACT [GOC:mah] is_a: GO:0006982 ! response to lipid hydroperoxide is_a: GO:0071447 ! cellular response to hydroperoxide [Term] id: GO:0071450 name: cellular response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:mah] subset: gosubset_prok is_a: GO:0000305 ! response to oxygen radical is_a: GO:0034614 ! cellular response to reactive oxygen species [Term] id: GO:0071451 name: cellular response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:mah] subset: gosubset_prok is_a: GO:0000303 ! response to superoxide is_a: GO:0071450 ! cellular response to oxygen radical [Term] id: GO:0071452 name: cellular response to singlet oxygen namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:mah] subset: gosubset_prok is_a: GO:0000304 ! response to singlet oxygen is_a: GO:0034614 ! cellular response to reactive oxygen species [Term] id: GO:0071453 name: cellular response to oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah] is_a: GO:0070482 ! response to oxygen levels is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0071454 name: cellular response to anoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:mah] comment: Note that this term should not be confused with 'cellular response to hypoxia ; GO:0071456'. synonym: "cellular response to anaerobic conditions" EXACT [GOC:elh] synonym: "cellular response to anoxic stress" EXACT [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034059 ! response to anoxia is_a: GO:0071453 ! cellular response to oxygen levels [Term] id: GO:0071455 name: cellular response to hyperoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:mah] synonym: "cellular response to hyperoxic stress" EXACT [GOC:mah] synonym: "cellular response to increased oxygen tension" EXACT [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0055093 ! response to hyperoxia is_a: GO:0071453 ! cellular response to oxygen levels [Term] id: GO:0071456 name: cellular response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] comment: Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "cellular response to hypoxic stress" EXACT [GOC:mah] synonym: "cellular response to lowered oxygen tension" EXACT [GOC:mah] is_a: GO:0001666 ! response to hypoxia is_a: GO:0033554 ! cellular response to stress is_a: GO:0071453 ! cellular response to oxygen levels [Term] id: GO:0071457 name: cellular response to ozone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:mah] is_a: GO:0010193 ! response to ozone is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0071458 name: integral to cytosolic side of endoplasmic reticulum membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the cytosol." [GOC:mah] synonym: "integral to cytosolic side of ER membrane" EXACT [GOC:mah] synonym: "integral to ER membrane, cytosolic side" EXACT [GOC:vw] is_a: GO:0030176 ! integral to endoplasmic reticulum membrane [Term] id: GO:0071459 name: protein localization to chromosome, centromeric region namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome." [GOC:mah] synonym: "protein localisation to chromosome, centromeric region" EXACT [GOC:mah] synonym: "protein localization to centromere" EXACT [GOC:mah] synonym: "protein localization to chromosome, centric region" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome [Term] id: GO:0071460 name: cellular response to cell-matrix adhesion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion." [GOC:sl, PMID:11425869] is_a: GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0071461 name: cellular response to redox state namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah] subset: gosubset_prok synonym: "cellular redox signal response" EXACT [GOC:mah] is_a: GO:0051775 ! response to redox state [Term] id: GO:0071462 name: cellular response to water namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0009415 ! response to water is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:0071214 ! cellular response to abiotic stimulus [Term] id: GO:0071463 name: cellular response to humidity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:mah] is_a: GO:0009270 ! response to humidity is_a: GO:0071462 ! cellular response to water [Term] id: GO:0071464 name: cellular response to hydrostatic pressure namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:mah] synonym: "cellular response to biomechanical stress" BROAD [GOC:mah] synonym: "cellular response to static fluid pressure" EXACT [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0051599 ! response to hydrostatic pressure is_a: GO:0071462 ! cellular response to water [Term] id: GO:0071465 name: cellular response to desiccation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:mah] subset: gosubset_prok synonym: "desiccation tolerance" RELATED [GOC:mah] is_a: GO:0009269 ! response to desiccation is_a: GO:0042631 ! cellular response to water deprivation [Term] id: GO:0071466 name: cellular response to xenobiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:mah] subset: gosubset_prok is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0071467 name: cellular response to pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0009268 ! response to pH is_a: GO:0071214 ! cellular response to abiotic stimulus [Term] id: GO:0071468 name: cellular response to acidity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7." [GOC:mah] synonym: "cellular response to acidic pH" EXACT [GOC:mah] is_a: GO:0010447 ! response to acidity is_a: GO:0071467 ! cellular response to pH [Term] id: GO:0071469 name: cellular response to alkalinity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7." [GOC:mah] synonym: "cellular response to alkaline pH" EXACT [GOC:mah] synonym: "cellular response to basic pH" EXACT [GOC:mah] is_a: GO:0010446 ! response to alkalinity is_a: GO:0071467 ! cellular response to pH [Term] id: GO:0071470 name: cellular response to osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] subset: gosubset_prok synonym: "cellular osmotic response" EXACT [GOC:mah] synonym: "cellular osmotic stress response" EXACT [GOC:mah] is_a: GO:0006970 ! response to osmotic stress is_a: GO:0033554 ! cellular response to stress is_a: GO:0071214 ! cellular response to abiotic stimulus [Term] id: GO:0071471 name: cellular response to non-ionic osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:mah] is_a: GO:0010335 ! response to non-ionic osmotic stress is_a: GO:0071470 ! cellular response to osmotic stress [Term] id: GO:0071472 name: cellular response to salt stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] subset: gosubset_prok synonym: "cellular response to ionic osmotic stress" EXACT [GOC:mah] synonym: "cellular salinity response" EXACT [GOC:mah] is_a: GO:0009651 ! response to salt stress is_a: GO:0071470 ! cellular response to osmotic stress [Term] id: GO:0071473 name: cellular response to cation stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:mah] subset: gosubset_prok is_a: GO:0043157 ! response to cation stress is_a: GO:0071472 ! cellular response to salt stress [Term] id: GO:0071474 name: cellular hyperosmotic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:mah] synonym: "cellular HOG response" EXACT [GOC:mah] synonym: "cellular hypertonic response" EXACT [GOC:mah] synonym: "cellular response to hypertonicity" EXACT [GOC:mah, GOC:yaf] is_a: GO:0006972 ! hyperosmotic response is_a: GO:0071470 ! cellular response to osmotic stress [Term] id: GO:0071475 name: cellular hyperosmotic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] synonym: "cellular response to hyperosmotic salt stress" EXACT [GOC:mah] is_a: GO:0042538 ! hyperosmotic salinity response is_a: GO:0071472 ! cellular response to salt stress is_a: GO:0071474 ! cellular hyperosmotic response [Term] id: GO:0071476 name: cellular hypotonic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:mah] synonym: "cellular hypo-osmotic response" EXACT [GOC:mah] is_a: GO:0006971 ! hypotonic response is_a: GO:0071470 ! cellular response to osmotic stress [Term] id: GO:0071477 name: cellular hypotonic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] synonym: "cellular response to hypotonic salt stress" EXACT [GOC:mah] is_a: GO:0042539 ! hypotonic salinity response is_a: GO:0071472 ! cellular response to salt stress is_a: GO:0071476 ! cellular hypotonic response [Term] id: GO:0071478 name: cellular response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. subset: gosubset_prok synonym: "cellular response to electromagnetic radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to radiation stimulus" EXACT [GOC:mah] is_a: GO:0009314 ! response to radiation is_a: GO:0071214 ! cellular response to abiotic stimulus [Term] id: GO:0071479 name: cellular response to ionizing radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah] synonym: "cellular response to ionising radiation" EXACT [GOC:mah] synonym: "cellular response to ionizing radiation stimulus" EXACT [GOC:mah] is_a: GO:0010212 ! response to ionizing radiation is_a: GO:0071478 ! cellular response to radiation [Term] id: GO:0071480 name: cellular response to gamma radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah] synonym: "cellular response to gamma ray" RELATED [GOC:mah] synonym: "cellular response to gamma-ray photon" RELATED [GOC:mah] is_a: GO:0010332 ! response to gamma radiation is_a: GO:0071479 ! cellular response to ionizing radiation [Term] id: GO:0071481 name: cellular response to X-ray namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah] synonym: "cellular response to X-ray radiation stimulus" EXACT [GOC:mah] is_a: GO:0010165 ! response to X-ray is_a: GO:0071479 ! cellular response to ionizing radiation [Term] id: GO:0071482 name: cellular response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah] subset: gosubset_prok is_a: GO:0009416 ! response to light stimulus is_a: GO:0071478 ! cellular response to radiation [Term] id: GO:0071483 name: cellular response to blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:mah] synonym: "cellular response to blue light stimulus" EXACT [GOC:mah] is_a: GO:0009637 ! response to blue light is_a: GO:0071482 ! cellular response to light stimulus [Term] id: GO:0071484 name: cellular response to light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:mah] is_a: GO:0009642 ! response to light intensity is_a: GO:0071482 ! cellular response to light stimulus [Term] id: GO:0071485 name: cellular response to absence of light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:mah] is_a: GO:0009646 ! response to absence of light is_a: GO:0071484 ! cellular response to light intensity [Term] id: GO:0071486 name: cellular response to high light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:mah] is_a: GO:0009644 ! response to high light intensity is_a: GO:0071484 ! cellular response to light intensity [Term] id: GO:0071487 name: cellular response to low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:mah] is_a: GO:0009645 ! response to low light intensity stimulus is_a: GO:0071484 ! cellular response to light intensity [Term] id: GO:0071488 name: cellular response to very low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mah] is_a: GO:0055122 ! response to very low light intensity stimulus is_a: GO:0071484 ! cellular response to light intensity [Term] id: GO:0071489 name: cellular response to red or far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] is_a: GO:0009639 ! response to red or far red light is_a: GO:0071482 ! cellular response to light stimulus [Term] id: GO:0071490 name: cellular response to far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] synonym: "cellular response to far red light stimulus" EXACT [GOC:mah] is_a: GO:0010218 ! response to far red light is_a: GO:0071489 ! cellular response to red or far red light [Term] id: GO:0071491 name: cellular response to red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] synonym: "cellular response to red light stimulus" EXACT [GOC:mah] is_a: GO:0010114 ! response to red light is_a: GO:0071489 ! cellular response to red or far red light [Term] id: GO:0071492 name: cellular response to UV-A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 400 to 500 nm." [GOC:mah] synonym: "cellular response to UV-A light stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-A radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UVA light stimulus" EXACT [GOC:mah] synonym: "cellular response to UVA radiation stimulus" EXACT [GOC:mah] is_a: GO:0034644 ! cellular response to UV is_a: GO:0070141 ! response to UV-A [Term] id: GO:0071493 name: cellular response to UV-B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 290 to 320 nm." [GOC:mah] synonym: "cellular response to medium wave ultraviolet light stimulus" EXACT [GOC:mah] synonym: "cellular response to medium wave ultraviolet radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-B light stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-B radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UVB light stimulus" EXACT [GOC:mah] synonym: "cellular response to UVB radiation stimulus" EXACT [GOC:mah] is_a: GO:0010224 ! response to UV-B is_a: GO:0034644 ! cellular response to UV [Term] id: GO:0071494 name: cellular response to UV-C namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 290 nm." [GOC:mah] synonym: "cellular response to germicidal ultraviolet light stimulus" EXACT [GOC:mah] synonym: "cellular response to germicidal ultraviolet radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to shortwave ultraviolet light stimulus" EXACT [GOC:mah] synonym: "cellular response to shortwave ultraviolet radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-C light stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-C radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UVC light stimulus" EXACT [GOC:mah] synonym: "cellular response to UVC radiation stimulus" EXACT [GOC:mah] is_a: GO:0010225 ! response to UV-C is_a: GO:0034644 ! cellular response to UV [Term] id: GO:0071495 name: cellular response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] subset: gosubset_prok is_a: GO:0009719 ! response to endogenous stimulus [Term] id: GO:0071496 name: cellular response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to environmental stimulus" EXACT [GOC:mah] is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0071497 name: cellular response to freezing namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:mah] subset: gosubset_prok synonym: "antifreeze activity" RELATED [GOC:mah] synonym: "ice nucleation inhibitor activity" RELATED [GOC:mah] is_a: GO:0050826 ! response to freezing is_a: GO:0070417 ! cellular response to cold [Term] id: GO:0071498 name: cellular response to fluid shear stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034405 ! response to fluid shear stress [Term] id: GO:0071499 name: cellular response to laminar fluid shear stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers." [GOC:mah] is_a: GO:0034616 ! response to laminar fluid shear stress is_a: GO:0071498 ! cellular response to fluid shear stress [Term] id: GO:0071500 name: cellular response to nitrosative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0051409 ! response to nitrosative stress [Term] id: GO:0071501 name: cellular response to sterol depletion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:mah] synonym: "cellular sterol depletion response" EXACT [GOC:mah] is_a: GO:0006991 ! response to sterol depletion is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0071502 name: cellular response to temperature stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to thermal stimulus" EXACT [GOC:mah] is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0071503 name: response to heparin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0071504 name: cellular response to heparin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071503 ! response to heparin [Term] id: GO:0071505 name: response to mycophenolic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [CHEBI:168396, GOC:mah] synonym: "response to mycophenolate" EXACT [GOC:mah] is_a: GO:0070542 ! response to fatty acid [Term] id: GO:0071506 name: cellular response to mycophenolic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [CHEBI:168396, GOC:mah] synonym: "cellular response to mycophenolate" EXACT [GOC:mah] is_a: GO:0071398 ! cellular response to fatty acid is_a: GO:0071505 ! response to mycophenolic acid [Term] id: GO:0071507 name: MAPKKK cascade involved in conjugation with cellular fusion namespace: biological_process def: "A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of conjugation with cellular fusion." [GOC:mah, GOC:vw] synonym: "conjugation with cellular fusion, MAPKKK cascade" EXACT [GOC:mah] synonym: "MAPKKK cascade involved in mating response" RELATED [GOC:mah] is_a: GO:0000165 ! MAPKKK cascade is_a: GO:0032005 ! regulation of conjugation with cellular fusion by signal transduction relationship: part_of GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion [Term] id: GO:0071508 name: activation of MAPK activity involved in conjugation with cellular fusion namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah] synonym: "activation of MAPK activity involved in mating response" RELATED [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAPK activity" EXACT [GOC:mah] is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion [Term] id: GO:0071509 name: activation of MAPKK activity involved in conjugation with cellular fusion namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of conjugation with cellular fusion." [GOC:mah] synonym: "activation of MAP kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah] synonym: "activation of MAPKK activity involved in mating response" RELATED [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAP kinase kinase activity" EXACT [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAPKK activity" EXACT [GOC:mah] is_a: GO:0000186 ! activation of MAPKK activity is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion [Term] id: GO:0071510 name: activation of MAPKKK activity involved in conjugation with cellular fusion namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of conjugation with cellular fusion." [GOC:mah] synonym: "activation of MAP kinase kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah] synonym: "activation of MAPKKK activity involved in mating response" RELATED [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAP kinase kinase kinase activity" EXACT [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAPKKK activity" EXACT [GOC:mah] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion [Term] id: GO:0071511 name: inactivation of MAPK activity involved in conjugation with cellular fusion namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah] synonym: "conjugation with cellular fusion, inactivation of MAPK activity" EXACT [GOC:mah] synonym: "conjugation with cellular fusion, termination of MAPK activity" EXACT [GOC:mah] synonym: "inactivation of MAPK activity involved in mating response" RELATED [GOC:mah] synonym: "termination of MAPK activity during conjugation with cellular fusion" EXACT [GOC:mah] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion [Term] id: GO:0071512 name: MAPK import into nucleus involved in conjugation with cellular fusion namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus that occurs in the context of conjugation with cellular fusion." [GOC:mah] synonym: "conjugation with cellular fusion, MAPK import into nucleus" EXACT [GOC:mah] synonym: "conjugation with cellular fusion, nuclear translocation of MAPK" NARROW [GOC:mah] synonym: "MAPK import into nucleus involved in mating response" RELATED [GOC:mah] synonym: "nuclear translocation of MAPK involved in conjugation with cellular fusion" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in mating response" RELATED [GOC:mah] is_a: GO:0000189 ! MAPK import into nucleus relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion [Term] id: GO:0071513 name: phosphopantothenoylcysteine decarboxylase complex namespace: cellular_component def: "A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces." [GOC:jh, PMID:19915539] comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0071514 name: genetic imprinting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [GOC:mah, GOC:vw] synonym: "DNA imprinting" EXACT [GOC:mah] is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process [Term] id: GO:0071515 name: genetic imprinting at mating-type locus namespace: biological_process def: "A genetic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894] synonym: "mating type determination, imprinting" EXACT [GOC:vw] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0031494 ! regulation of mating type switching is_a: GO:0071514 ! genetic imprinting [Term] id: GO:0071516 name: establishment of imprinting at mating-type locus namespace: biological_process def: "The initial formation of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:18723894] synonym: "mating type determination, establishment of imprinting" EXACT [GOC:vw] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0071515 ! genetic imprinting at mating-type locus [Term] id: GO:0071517 name: maintenance of imprinting at mating-type locus namespace: biological_process def: "Any process involved in preserving the structure of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894] synonym: "mating type determination, maintenance of imprinting" EXACT [GOC:mah] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0071515 ! genetic imprinting at mating-type locus [Term] id: GO:0071518 name: autoinducer-2 kinase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP." [GOC:imk, PMID:17274596, PMID:20025244] synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [CHEBI:425228, GOC:mah] xref: MetaCyc:RXN0-5461 is_a: GO:0016301 ! kinase activity [Term] id: GO:0071519 name: actin filament bundle assembly involved in actomyosin contractile ring formation namespace: biological_process def: "A process of actin filament bundle formation that occurs in the context of assembling an actomyosin contractile ring during cytokinesis." [GOC:mah, PMID:19713940] is_a: GO:0051017 ! actin filament bundle assembly is_a: GO:2000689 ! actin filament organization involved in cytokinetic actomyosin contractile ring assembly relationship: part_of GO:0000915 ! cytokinesis, actomyosin contractile ring assembly [Term] id: GO:0071520 name: actin filament bundle convergence involved in actomyosin contractile ring formation namespace: biological_process def: "A process of actin filament bundle distribution that occurs in the context of assembling an actomyosin contractile ring during cytokinesis, and that results in the compaction of actin filaments into a tight ring." [GOC:mah, PMID:19713940] is_a: GO:0070650 ! actin filament bundle distribution is_a: GO:2000689 ! actin filament organization involved in cytokinetic actomyosin contractile ring assembly relationship: part_of GO:0000915 ! cytokinesis, actomyosin contractile ring assembly [Term] id: GO:0071521 name: Cdc42 GTPase complex namespace: cellular_component def: "A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway." [GOC:mah, GOC:vw, PMID:10567532, PMID:7923372, PMID:8943016] synonym: "Ras1-Scd1-Scd2-Cdc42-Shk1 complex" EXACT [GOC:vw] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0071522 name: ureidoglycine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3." [MetaCyc:URUR-RXN, PMID:19935661, PMID:20038185] subset: gosubset_prok xref: EC:3.5.3.- xref: MetaCyc:URUR-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0071523 name: TIR domain-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TIR domain interaction." [GOC:amm] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071524 name: pyrrolysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [CHEBI:21860, GOC:dh, PMID:17204561] subset: gosubset_prok synonym: "monomethylamine methyltransferase cofactor lysine adduct biosynthetic process" EXACT [CHEBI:21860] synonym: "pyrrolysine anabolism" EXACT [GOC:mah] synonym: "pyrrolysine biosynthesis" EXACT [GOC:mah] synonym: "pyrrolysine formation" EXACT [GOC:mah] synonym: "pyrrolysine synthesis" EXACT [GOC:mah] is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0071525 ! pyrrolysine metabolic process [Term] id: GO:0071525 name: pyrrolysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [CHEBI:21860, GOC:mah, PMID:17204561] subset: gosubset_prok synonym: "monomethylamine methyltransferase cofactor lysine adduct metabolic process" EXACT [CHEBI:21860] synonym: "pyrrolysine metabolism" EXACT [GOC:mah] is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0071526 name: semaphorin-plexin signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959] synonym: "semaphorin-plexin signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0071527 name: semaphorin-plexin signaling pathway involved in outflow tract morphogenesis namespace: biological_process def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand that contributes to outflow tract morphogenesis." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959] synonym: "semaphorin-plexin signalling pathway involved in outflow tract morphogenesis" EXACT [GOC:mah] is_a: GO:0071526 ! semaphorin-plexin signaling pathway relationship: part_of GO:0003151 ! outflow tract morphogenesis [Term] id: GO:0071528 name: tRNA re-export from nucleus namespace: biological_process def: "The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export." [GOC:mcc, PMID:17475781, PMID:20032305] synonym: "tRNA reexport from nucleus" EXACT [GOC:mcc] is_a: GO:0006409 ! tRNA export from nucleus [Term] id: GO:0071529 name: cementum mineralization namespace: biological_process def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum." [GOC:sl, PMID:17043865] synonym: "cementum formation" RELATED [GOC:mah] is_a: GO:0034505 ! tooth mineralization [Term] id: GO:0071530 name: FHA domain-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction." [GOC:amm, InterPro:IPR000253] synonym: "forkhead-associated domain-mediated complex assembly" EXACT [GOC:mah] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071531 name: Rel homology domain-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction." [GOC:amm, InterPro:IPR011539] synonym: "RHD domain-mediated complex assembly" EXACT [GOC:mah] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071532 name: ankyrin repeat binding namespace: molecular_function def: "Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure." [GOC:mah, InterPro:IPR002110] synonym: "ANK repeat binding" EXACT [GOC:amm] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0071533 name: ankyrin repeat-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an ankyrin repeat interaction." [GOC:amm, InterPro:IPR002110] synonym: "ANK repeat-mediated complex assembly" EXACT [GOC:amm] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071534 name: zf-TRAF domain-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TRAF-type zinc finger (zf-TRAF) domain interaction." [GOC:amm, InterPro:IPR001293] synonym: "TRAF-type zinc finger domain-mediated complex assembly" EXACT [GOC:mah] synonym: "zinc finger TRAF-type domain-mediated complex assembly" EXACT [GOC:mah] synonym: "zinc-finger-TRAF domain-mediated complex assembly" EXACT [GOC:mah] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071535 name: RING-like zinc finger domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain." [GOC:mah, InterPro:IPR014857] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0071536 name: RING-like zinc finger domain-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RING-like zinc finger domain interaction." [GOC:amm, InterPro:IPR014857] synonym: "RING-like domain-mediated complex assembly" EXACT [GOC:mah] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071537 name: C3HC4-type RING finger domain-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a C3HC4-type RING finger domain interaction." [GOC:amm, InterPro:IPR018957] synonym: "zinc finger C3HC4 type domain-mediated complex assembly" EXACT [GOC:amm] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071538 name: SH2 domain-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an SH2 domain interaction." [GOC:amm] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071539 name: protein localization to centrosome namespace: biological_process def: "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd] synonym: "protein localisation to centrosome" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0071540 name: eukaryotic translation initiation factor 3 complex, eIF3e namespace: cellular_component def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." [PMID:15904532, PMID:19061185] synonym: "eIF3e-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah] is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex [Term] id: GO:0071541 name: eukaryotic translation initiation factor 3 complex, eIF3m namespace: cellular_component def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185] synonym: "eIF3m-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah] is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex [Term] id: GO:0071542 name: dopaminergic neuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine." [GOC:rph] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0071543 name: diphosphoinositol polyphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729] synonym: "diphosphoinositol polyphosphate metabolism" EXACT [GOC:mah] is_a: GO:0043647 ! inositol phosphate metabolic process [Term] id: GO:0071544 name: diphosphoinositol polyphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729] synonym: "diphosphoinositol polyphosphate breakdown" EXACT [GOC:mah] synonym: "diphosphoinositol polyphosphate catabolism" EXACT [GOC:mah] synonym: "diphosphoinositol polyphosphate degradation" EXACT [GOC:mah] is_a: GO:0071543 ! diphosphoinositol polyphosphate metabolic process is_a: GO:0071545 ! inositol phosphate catabolic process [Term] id: GO:0071545 name: inositol phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah] comment: See also the biological process term 'inositol phosphate dephosphorylation ; GO:0046855'. synonym: "inositol phosphate breakdown" EXACT [GOC:mah] synonym: "inositol phosphate catabolism" EXACT [GOC:mah] synonym: "inositol phosphate degradation" EXACT [GOC:mah] synonym: "myo-inositol phosphate catabolic process" NARROW [GOC:mah] is_a: GO:0043647 ! inositol phosphate metabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0071546 name: pi-body namespace: cellular_component def: "A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505] synonym: "intermitochondrial cement" EXACT [GOC:sp] is_a: GO:0043186 ! P granule [Term] id: GO:0071547 name: piP-body namespace: cellular_component def: "A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway." [GOC:sp, PMID:20011505] is_a: GO:0043186 ! P granule [Term] id: GO:0071548 name: response to dexamethasone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf] is_a: GO:0051384 ! response to glucocorticoid stimulus [Term] id: GO:0071549 name: cellular response to dexamethasone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf] is_a: GO:0051414 ! response to cortisol stimulus is_a: GO:0071385 ! cellular response to glucocorticoid stimulus is_a: GO:0071548 ! response to dexamethasone stimulus [Term] id: GO:0071550 name: death domain-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction." [GOC:amm, InterPro:IPR000488] synonym: "DD-mediated complex assembly" EXACT [GOC:mah] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071551 name: RIP homotypic interaction motif binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases." [GOC:mah, PMID:11734559] synonym: "RHIM binding" EXACT [GOC:mah] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0071552 name: RIP homotypic interaction motif-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RIP homotypic interaction motif (RHIM) interaction." [GOC:amm, PMID:11734559] synonym: "RHIM-mediated complex assembly" EXACT [GOC:mah] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071553 name: pyrimidinergic nucleotide receptor activity, G-protein coupled namespace: molecular_function def: "Combining with a pyrimidine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:sl, PMID:10736418, PMID:12369950, PMID:15796906] synonym: "G protein coupled pyrimidinergic nucleotide receptor activity" EXACT [] synonym: "G-protein coupled pyrimidinergic nucleotide receptor activity" EXACT [] synonym: "G-protein-coupled pyrimidinergic nucleotide receptor activity" EXACT [] synonym: "pyrimidinergic nucleotide receptor activity, G protein coupled" EXACT [] is_a: GO:0001608 ! nucleotide receptor activity, G-protein coupled is_a: GO:0016502 ! nucleotide receptor activity [Term] id: GO:0071554 name: cell wall organization or biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah] is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0071555 name: cell wall organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah] subset: goslim_candida subset: goslim_pir subset: gosubset_prok synonym: "cell wall organisation" EXACT [GOC:curators] synonym: "cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0071556 name: integral to lumenal side of endoplasmic reticulum membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the lumen." [GOC:mah] synonym: "integral to ER membrane, lumenal side" EXACT [GOC:vw] synonym: "integral to lumenal side of ER membrane" EXACT [GOC:mah] is_a: GO:0030176 ! integral to endoplasmic reticulum membrane [Term] id: GO:0071557 name: histone H3-K27 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone." [GOC:sp, PMID:20023638] synonym: "H3K27 demethylation" RELATED [GOC:mah] is_a: GO:0070076 ! histone lysine demethylation [Term] id: GO:0071558 name: histone demethylase activity (H3-K27 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein." [GOC:sp, PMID:20622853] is_a: GO:0032452 ! histone demethylase activity [Term] id: GO:0071559 name: response to transforming growth factor beta stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah] synonym: "response to TGF-beta stimulus" EXACT [GOC:mah] synonym: "response to TGFbeta stimulus" EXACT [GOC:mah] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor stimulus [Term] id: GO:0071560 name: cellular response to transforming growth factor beta stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575] synonym: "cellular response to TGF-beta stimulus" EXACT [GOC:mah] synonym: "cellular response to TGFbeta stimulus" EXACT [GOC:mah] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:0071559 ! response to transforming growth factor beta stimulus [Term] id: GO:0071561 name: nucleus-vacuole junction namespace: cellular_component def: "An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156, PMID:16806880] synonym: "nucleus-vacuole membrane contact site" EXACT [GOC:mah] synonym: "NV junction" EXACT [GOC:jp, PMID:16709156] synonym: "NVJ" EXACT [GOC:mah, PMID:16806880] is_a: GO:0044232 ! organelle membrane contact site [Term] id: GO:0071562 name: nucleus-vacuole junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction, which are membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156] synonym: "nucleus-vacuole junction formation" EXACT [GOC:jp] synonym: "NV junction assembly" EXACT [GOC:jp, PMID:16709156] synonym: "NV junction formation" EXACT [GOC:jp, PMID:16709156] synonym: "NVJ assembly" EXACT [GOC:mah, PMID:16806880] synonym: "NVJ formation" EXACT [GOC:mah, PMID:16806880] is_a: GO:0022614 ! membrane to membrane docking is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0034727 ! piecemeal microautophagy of nucleus [Term] id: GO:0071563 name: Myo2p-Vac17p-Vac8p transport complex namespace: cellular_component def: "A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p." [GOC:jp, PMID:12594460] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0071564 name: npBAF complex namespace: cellular_component def: "A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells." [GOC:mah, GOC:ss, PMID:17640523] is_a: GO:0070603 ! SWI/SNF-type complex [Term] id: GO:0071565 name: nBAF complex namespace: cellular_component def: "A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth." [GOC:mah, GOC:ss, PMID:17640523] is_a: GO:0070603 ! SWI/SNF-type complex [Term] id: GO:0071566 name: UFM1 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:sp, PMID:20018847] is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0071567 name: UFM1 hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates." [GOC:sp, PMID:20018847] is_a: GO:0019783 ! small conjugating protein-specific protease activity [Term] id: GO:0071568 name: UFM1 conjugating enzyme activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein UFM1 to other proteins or other substrate molecules." [GOC:sp, PMID:20018847] is_a: GO:0019787 ! small conjugating protein ligase activity [Term] id: GO:0071569 name: protein ufmylation namespace: biological_process def: "Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847] is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0071570 name: cement gland development namespace: biological_process def: "The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed." [GOC:bf] is_a: GO:0048732 ! gland development [Term] id: GO:0071571 name: LRR domain-mediated complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an LRR (leucine-rich repeat) domain interaction." [GOC:amm, InterPro:IPR001611] synonym: "leucine-rich repeat domain-mediated complex assembly" EXACT [GOC:mah] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071572 name: histone H3-K56 deacetylation namespace: biological_process def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone." [GOC:mah] is_a: GO:0070932 ! histone H3 deacetylation [Term] id: GO:0071573 name: telosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a telosome. A telosome is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase." [GOC:mah, GOC:vw] synonym: "Pot1 complex assembly" EXACT [GOC:mah] synonym: "Pot1-Tpz1 complex assembly" EXACT [GOC:mah] synonym: "shelterin complex formation" EXACT [GOC:mah] is_a: GO:0065004 ! protein-DNA complex assembly [Term] id: GO:0071574 name: protein localization to medial cortex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the medial cortex." [GOC:mah] synonym: "protein localisation to medial cortex" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0071575 name: integral to external side of plasma membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of the plasma membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm." [GOC:mah] is_a: GO:0005887 ! integral to plasma membrane is_a: GO:0031233 ! intrinsic to external side of plasma membrane [Term] id: GO:0071576 name: tetrahydrodictyopterin binding namespace: molecular_function def: "Interacting selectively with tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one." [CHEBI:52447, GOC:mah] synonym: "D-threo-tetrahydrobiopterin" EXACT [GOC:mah] synonym: "DH4 binding" EXACT [GOC:mah] is_a: GO:0034617 ! tetrahydrobiopterin binding [Term] id: GO:0071577 name: zinc ion transmembrane transport namespace: biological_process def: "A process in which a zinc ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] synonym: "zinc transmembrane transport" EXACT [GOC:mah] is_a: GO:0006829 ! zinc ion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0071578 name: zinc ion import namespace: biological_process def: "The directed movement of zinc ions across a membrane into a cell or organelle." [GOC:BHF, GOC:mah] synonym: "zinc import" EXACT [GOC:mah] synonym: "zinc uptake" EXACT [GOC:mah] is_a: GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0071579 name: regulation of zinc ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] is_a: GO:0010959 ! regulation of metal ion transport relationship: regulates GO:0006829 ! zinc ion transport [Term] id: GO:0071580 name: regulation of zinc ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah] is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0065007 ! biological regulation is_a: GO:0071579 ! regulation of zinc ion transport relationship: regulates GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0071581 name: regulation of zinc ion import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah] is_a: GO:0065007 ! biological regulation is_a: GO:0071580 ! regulation of zinc ion transmembrane transport relationship: regulates GO:0071578 ! zinc ion import [Term] id: GO:0071582 name: negative regulation of zinc ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0071579 ! regulation of zinc ion transport relationship: negatively_regulates GO:0006829 ! zinc ion transport [Term] id: GO:0071583 name: negative regulation of zinc ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah] is_a: GO:0034766 ! negative regulation of ion transmembrane transport is_a: GO:0071580 ! regulation of zinc ion transmembrane transport is_a: GO:0071582 ! negative regulation of zinc ion transport relationship: negatively_regulates GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0071584 name: negative regulation of zinc ion import namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah] is_a: GO:0071581 ! regulation of zinc ion import is_a: GO:0071583 ! negative regulation of zinc ion transmembrane transport relationship: negatively_regulates GO:0071578 ! zinc ion import [Term] id: GO:0071585 name: detoxification of cadmium ion namespace: biological_process def: "Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion." [GOC:BHF, PMID:16741752] is_a: GO:0009636 ! response to toxin is_a: GO:0046686 ! response to cadmium ion [Term] id: GO:0071586 name: CAAX-box protein processing namespace: biological_process def: "The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah] is_a: GO:0051605 ! protein maturation by peptide bond cleavage relationship: part_of GO:0080120 ! CAAX-box protein maturation [Term] id: GO:0071587 name: CAAX-box protein modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins." [GOC:mah] is_a: GO:0043687 ! post-translational protein modification relationship: part_of GO:0080120 ! CAAX-box protein maturation [Term] id: GO:0071588 name: hydrogen peroxide mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of hydrogen peroxide (H2O2)." [GOC:mah, PMID:17043891] synonym: "H2O2 mediated signaling pathway" EXACT [GOC:mah] synonym: "hydrogen peroxide mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction [Term] id: GO:0071589 name: pyridine nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any pyridine nucleoside, one of a family of organic molecules consisting of a pyridine base covalently bonded to a sugar, usually ribose." [CHEBI:47896, GOC:mah] subset: gosubset_prok synonym: "pyridine nucleoside anabolism" EXACT [GOC:mah] synonym: "pyridine nucleoside biosynthesis" EXACT [GOC:mah] synonym: "pyridine nucleoside formation" EXACT [GOC:mah] synonym: "pyridine nucleoside synthesis" EXACT [GOC:mah] is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0070637 ! pyridine nucleoside metabolic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process [Term] id: GO:0071590 name: nicotinamide riboside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [CHEBI:15927, GOC:mah, PMID:19846558] synonym: "N-ribosylnicotinamide biosynthetic process" EXACT [CHEBI:15927] synonym: "nicotinamide riboside anabolism" EXACT [GOC:mah] synonym: "nicotinamide riboside biosynthesis" EXACT [GOC:mah] synonym: "nicotinamide riboside formation" EXACT [GOC:mah] synonym: "nicotinamide riboside synthesis" EXACT [GOC:mah] is_a: GO:0046495 ! nicotinamide riboside metabolic process is_a: GO:0071589 ! pyridine nucleoside biosynthetic process [Term] id: GO:0071591 name: nicotinic acid riboside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [CHEBI:27748, GOC:mah, PMID:19846558] synonym: "D-ribosylnicotinic acid metabolic process" EXACT [CHEBI:27748] synonym: "nicotinic acid riboside metabolism" EXACT [GOC:mah] is_a: GO:0070637 ! pyridine nucleoside metabolic process [Term] id: GO:0071592 name: nicotinic acid riboside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [CHEBI:27748, GOC:mah, PMID:19846558] synonym: "D-ribosylnicotinic acid biosynthetic process" EXACT [CHEBI:27748] synonym: "nicotinic acid riboside anabolism" EXACT [GOC:mah] synonym: "nicotinic acid riboside biosynthesis" EXACT [GOC:mah] synonym: "nicotinic acid riboside formation" EXACT [GOC:mah] synonym: "nicotinic acid riboside synthesis" EXACT [GOC:mah] is_a: GO:0071589 ! pyridine nucleoside biosynthetic process is_a: GO:0071591 ! nicotinic acid riboside metabolic process [Term] id: GO:0071593 name: lymphocyte aggregation namespace: biological_process def: "The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules." [GOC:sl] is_a: GO:0070486 ! leukocyte aggregation [Term] id: GO:0071594 name: thymocyte aggregation namespace: biological_process def: "The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules." [GOC:sl, PMID:1382990] synonym: "immature T cell aggregation" BROAD [CL:0000893, GOC:sl] synonym: "immature T-cell aggregation" BROAD [CL:0000893, GOC:mah] synonym: "immature T-lymphocyte aggregation" EXACT [CL:0000893, GOC:mah] synonym: "T cell precursor aggregation" EXACT [GOC:sl] synonym: "thymic lymphocyte aggregation" EXACT [GOC:sl] is_a: GO:0070489 ! T cell aggregation [Term] id: GO:0071595 name: Nem1-Spo7 phosphatase complex namespace: cellular_component def: "A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p." [GOC:mah, PMID:9822591] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0071596 name: ubiquitin-dependent protein catabolic process via the N-end rule pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437] synonym: "ubiquitin-dependent protein breakdown via the N-end rule pathway" EXACT [GOC:mah] synonym: "ubiquitin-dependent protein catabolism via the N-end rule pathway" EXACT [GOC:mah] synonym: "ubiquitin-dependent protein degradation via the N-end rule pathway" EXACT [GOC:mah] is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process [Term] id: GO:0071597 name: cellular birth scar namespace: cellular_component def: "Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation." [GOC:mcc, PMID:16672383, PMID:7730409] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009277 ! fungal-type cell wall [Term] id: GO:0071598 name: neuronal RNA granule namespace: cellular_component def: "A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli." [GOC:BHF, GOC:mah, PMID:19015237] is_a: GO:0035770 ! RNA granule is_a: GO:0044463 ! cell projection part relationship: part_of GO:0032838 ! cell projection cytoplasm relationship: part_of GO:0043005 ! neuron projection [Term] id: GO:0071599 name: otic vesicle development namespace: biological_process def: "The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah] is_a: GO:0007423 ! sensory organ development is_a: GO:0048839 ! inner ear development [Term] id: GO:0071600 name: otic vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah] is_a: GO:0042472 ! inner ear morphogenesis is_a: GO:0048562 ! embryonic organ morphogenesis relationship: part_of GO:0071599 ! otic vesicle development [Term] id: GO:0071601 name: sphere organelle namespace: cellular_component def: "A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins." [PMID:7758244, PMID:8349728] is_a: GO:0016604 ! nuclear body [Term] id: GO:0071602 name: phytosphingosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol." [CHEBI:46961, GOC:mah] synonym: "phytosphingosine anabolism" EXACT [GOC:mah] synonym: "phytosphingosine biosynthesis" EXACT [GOC:mah] synonym: "phytosphingosine formation" EXACT [GOC:mah] synonym: "phytosphingosine synthesis" EXACT [GOC:mah] is_a: GO:0006671 ! phytosphingosine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:0046520 ! sphingoid biosynthetic process [Term] id: GO:0071603 name: endothelial cell-cell adhesion namespace: biological_process def: "The attachment of an endothelial cell to another endothelial cell via adhesion molecules." [GOC:BHF] is_a: GO:0090136 ! epithelial cell-cell adhesion [Term] id: GO:0071604 name: transforming growth factor-beta production namespace: biological_process def: "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." [GOC:add, GOC:rv] synonym: "TGF-B production" EXACT [GOC:mah] synonym: "TGF-beta production" EXACT [GOC:mah] synonym: "TGFB production" EXACT [GOC:mah] synonym: "TGFb production" EXACT [GOC:rv] is_a: GO:0001816 ! cytokine production [Term] id: GO:0071605 name: monocyte chemotactic protein-1 production namespace: biological_process def: "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL2 production" EXACT [GOC:add, GOC:rv] synonym: "MCP-1 production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071606 name: chemokine (C-C motif) ligand 4 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL4 production" EXACT [GOC:add, GOC:rv] synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv] synonym: "MIP-1b production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071607 name: macrophage inflammatory protein-1 gamma production namespace: biological_process def: "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL9 production" EXACT [GOC:add, GOC:rv] synonym: "chemokine (C-C motif) ligand 9 production" EXACT [GOC:add, GOC:rv] synonym: "MIP-1g production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071608 name: macrophage inflammatory protein-1 alpha production namespace: biological_process def: "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL3 production" EXACT [GOC:add, GOC:rv] synonym: "chemokine (C-C motif) ligand 3 production" EXACT [GOC:add, GOC:rv] synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv] synonym: "MIP-1a production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071609 name: chemokine (C-C motif) ligand 5 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL5 production" EXACT [GOC:add, GOC:rv] synonym: "RANTES production" EXACT [GOC:bf] synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071610 name: chemokine (C-C motif) ligand 1 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL1 production" EXACT [GOC:add, GOC:rv] synonym: "T cell activation 3 production" EXACT [GOC:add, GOC:rv] synonym: "TCA-3 production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071611 name: granulocyte colony-stimulating factor production namespace: biological_process def: "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "colony stimulating factor 3 (granulocyte) production" EXACT [GOC:add] synonym: "CSF3 production" EXACT [GOC:add] synonym: "filgrastim production" EXACT [GOC:add] synonym: "G-CSF production" EXACT [GOC:add] synonym: "granulocyte colony stimulating factor production" EXACT [] synonym: "lenograstim production" EXACT [GOC:add] synonym: "pluripoietin production" EXACT [GOC:add] is_a: GO:0001816 ! cytokine production [Term] id: GO:0071612 name: IP-10 production namespace: biological_process def: "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "chemokine (C-C motif) ligand 10 production" EXACT [GOC:add, GOC:rv] synonym: "CXCL10 production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071613 name: granzyme B production namespace: biological_process def: "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0071614 name: linoleic acid epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid." [GOC:BHF, PMID:11042099] synonym: "linoleic acid monooxygenase activity" EXACT [GOC:mah] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0071615 name: oxidative deethylation namespace: biological_process def: "The process of removing one or more ethyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0071616 name: acyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk] subset: gosubset_prok synonym: "acyl-CoA anabolism" EXACT [GOC:mah] synonym: "acyl-CoA biosynthesis" EXACT [GOC:mah] synonym: "acyl-CoA formation" EXACT [GOC:mah] synonym: "acyl-CoA synthesis" EXACT [GOC:mah] is_a: GO:0006637 ! acyl-CoA metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0035384 ! thioester biosynthetic process [Term] id: GO:0071617 name: lysophospholipid acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk] is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0071618 name: lysophosphatidylethanolamine acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine." [GOC:cjk] is_a: GO:0071617 ! lysophospholipid acyltransferase activity [Term] id: GO:0071619 name: phosphorylation of RNA polymerase II C-terminal domain serine 2 residues namespace: biological_process def: "The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser5 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans." [GOC:krc, PMID:17079683] is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain [Term] id: GO:0071620 name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues namespace: biological_process def: "The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans)." [GOC:krc, PMID:17079683] is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain [Term] id: GO:0071621 name: granulocyte chemotaxis namespace: biological_process def: "The movement of a granulocyte in response to an external stimulus." [GOC:rph] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0071622 name: regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002688 ! regulation of leukocyte chemotaxis relationship: regulates GO:0071621 ! granulocyte chemotaxis [Term] id: GO:0071623 name: negative regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis relationship: negatively_regulates GO:0071621 ! granulocyte chemotaxis [Term] id: GO:0071624 name: positive regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis relationship: positively_regulates GO:0071621 ! granulocyte chemotaxis [Term] id: GO:0071625 name: vocalization behavior namespace: biological_process def: "The behavior in which an organism produces sounds by a mechanism involving its respiratory system." [GOC:mah] synonym: "vocalisation behaviour" EXACT [GOC:mah] is_a: GO:0007610 ! behavior [Term] id: GO:0071626 name: mastication namespace: biological_process def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg] synonym: "chewing" EXACT [GOC:mah] is_a: GO:0022600 ! digestive system process [Term] id: GO:0071627 name: integral to fungal-type vacuolar membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the fungal-type vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031166 ! integral to vacuolar membrane is_a: GO:0071628 ! intrinsic to fungal-type vacuolar membrane [Term] id: GO:0071628 name: intrinsic to fungal-type vacuolar membrane namespace: cellular_component def: "Located in the fungal-type vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] is_a: GO:0031310 ! intrinsic to vacuolar membrane relationship: part_of GO:0000329 ! fungal-type vacuole membrane [Term] id: GO:0071629 name: cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635] comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah] synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah] synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah] is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0071218 ! cellular response to misfolded protein [Term] id: GO:0071630 name: nucleus-associated proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635] comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. synonym: "nucleus-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah] synonym: "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah] synonym: "nucleus-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah] is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0071218 ! cellular response to misfolded protein [Term] id: GO:0071631 name: mating pheromone secretion involved in conjugation with cellular fusion namespace: biological_process def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh, GOC:jh, GOC:mah] synonym: "mating-type pheromone secretion involved in conjugation with cellular fusion" EXACT [GOC:vw] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0071835 ! mating pheromone secretion involved in conjugation relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0071632 name: optomotor response namespace: biological_process def: "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195] xref: Wikipedia:Optomotor_response is_a: GO:0007634 ! optokinetic behavior [Term] id: GO:0071633 name: dihydroceramidase activity namespace: molecular_function def: "Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine." [GOC:mah, PMID:10900202] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! ceramidase activity [Term] id: GO:0071634 name: regulation of transforming growth factor-beta production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] synonym: "regulation of TGF-B production" EXACT [GOC:mah] synonym: "regulation of TGF-beta production" EXACT [GOC:mah] synonym: "regulation of TGFB production" EXACT [GOC:mah] synonym: "regulation of TGFb production" EXACT [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0071604 ! transforming growth factor-beta production [Term] id: GO:0071635 name: negative regulation of transforming growth factor-beta production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] synonym: "negative regulation of TGF-B production" EXACT [GOC:mah] synonym: "negative regulation of TGF-beta production" EXACT [GOC:mah] synonym: "negative regulation of TGFB production" EXACT [GOC:mah] synonym: "negative regulation of TGFb production" EXACT [GOC:mah] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0071634 ! regulation of transforming growth factor-beta production relationship: negatively_regulates GO:0071604 ! transforming growth factor-beta production [Term] id: GO:0071636 name: positive regulation of transforming growth factor-beta production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] synonym: "positive regulation of TGF-B production" EXACT [GOC:mah] synonym: "positive regulation of TGF-beta production" EXACT [GOC:mah] synonym: "positive regulation of TGFB production" EXACT [GOC:mah] synonym: "positive regulation of TGFb production" EXACT [GOC:mah] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0071634 ! regulation of transforming growth factor-beta production relationship: positively_regulates GO:0071604 ! transforming growth factor-beta production [Term] id: GO:0071637 name: regulation of monocyte chemotactic protein-1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah] synonym: "regulation of CCL2 production" EXACT [GOC:mah] synonym: "regulation of MCP-1 production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0071605 ! monocyte chemotactic protein-1 production [Term] id: GO:0071638 name: negative regulation of monocyte chemotactic protein-1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah] synonym: "negative regulation of CCL2 production" EXACT [GOC:mah] synonym: "negative regulation of MCP-1 production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production relationship: negatively_regulates GO:0071605 ! monocyte chemotactic protein-1 production [Term] id: GO:0071639 name: positive regulation of monocyte chemotactic protein-1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah] synonym: "positive regulation of CCL2 production" EXACT [GOC:mah] synonym: "positive regulation of MCP-1 production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production relationship: positively_regulates GO:0071605 ! monocyte chemotactic protein-1 production [Term] id: GO:0071640 name: regulation of macrophage inflammatory protein 1 alpha production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah] synonym: "regulation of CCL3 production" EXACT [GOC:mah] synonym: "regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah] synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "regulation of MIP-1a production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production [Term] id: GO:0071641 name: negative regulation of macrophage inflammatory protein 1 alpha production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah] synonym: "negative regulation of CCL3 production" EXACT [GOC:mah] synonym: "negative regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah] synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "negative regulation of MIP-1a production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production relationship: negatively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production [Term] id: GO:0071642 name: positive regulation of macrophage inflammatory protein 1 alpha production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah] synonym: "positive regulation of CCL3 production" EXACT [GOC:mah] synonym: "positive regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah] synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "positive regulation of MIP-1a production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production relationship: positively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production [Term] id: GO:0071643 name: regulation of chemokine (C-C motif) ligand 4 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah] synonym: "regulation of CCL4 production" EXACT [GOC:mah] synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "regulation of MIP-1b production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production [Term] id: GO:0071644 name: negative regulation of chemokine (C-C motif) ligand 4 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah] synonym: "negative regulation of CCL4 production" EXACT [GOC:mah] synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "negative regulation of MIP-1b production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production relationship: negatively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production [Term] id: GO:0071645 name: positive regulation of chemokine (C-C motif) ligand 4 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah] synonym: "positive regulation of CCL4 production" EXACT [GOC:mah] synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "positive regulation of MIP-1b production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production relationship: positively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production [Term] id: GO:0071646 name: regulation of macrophage inflammatory protein-1 gamma production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah] synonym: "regulation of CCL9 production" EXACT [GOC:mah] synonym: "regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah] synonym: "regulation of MIP-1g production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production [Term] id: GO:0071647 name: negative regulation of macrophage inflammatory protein-1 gamma production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah] synonym: "negative regulation of CCL9 production" EXACT [GOC:mah] synonym: "negative regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah] synonym: "negative regulation of MIP-1g production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production relationship: negatively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production [Term] id: GO:0071648 name: positive regulation of macrophage inflammatory protein-1 gamma production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah] synonym: "positive regulation of CCL9 production" EXACT [GOC:mah] synonym: "positive regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah] synonym: "positive regulation of MIP-1g production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production relationship: positively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production [Term] id: GO:0071649 name: regulation of chemokine (C-C motif) ligand 5 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah] synonym: "regulation of CCL5 production" EXACT [GOC:mah] synonym: "regulation of RANTES production" EXACT [GOC:bf] synonym: "regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production [Term] id: GO:0071650 name: negative regulation of chemokine (C-C motif) ligand 5 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah] synonym: "negative regulation of CCL5 production" EXACT [GOC:mah] synonym: "negative regulation of RANTES production" EXACT [GOC:bf] synonym: "negative regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production relationship: negatively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production [Term] id: GO:0071651 name: positive regulation of chemokine (C-C motif) ligand 5 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah] synonym: "positive regulation of CCL5 production" EXACT [GOC:mah] synonym: "positive regulation of RANTES production" EXACT [GOC:bf] synonym: "positive regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production relationship: positively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production [Term] id: GO:0071652 name: regulation of chemokine (C-C motif) ligand 1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah] synonym: "regulation of CCL1 production" EXACT [GOC:mah] synonym: "regulation of T cell activation 3 production" EXACT [GOC:mah] synonym: "regulation of TCA-3 production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production [Term] id: GO:0071653 name: negative regulation of chemokine (C-C motif) ligand 1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah] synonym: "negative regulation of CCL1 production" EXACT [GOC:mah] synonym: "negative regulation of T cell activation 3 production" EXACT [GOC:mah] synonym: "negative regulation of TCA-3 production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production relationship: negatively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production [Term] id: GO:0071654 name: positive regulation of chemokine (C-C motif) ligand 1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah] synonym: "positive regulation of CCL1 production" EXACT [GOC:mah] synonym: "positive regulation of T cell activation 3 production" EXACT [GOC:mah] synonym: "positive regulation of TCA-3 production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production relationship: positively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production [Term] id: GO:0071655 name: regulation of granulocyte colony-stimulating factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah] synonym: "regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah] synonym: "regulation of CSF3 production" EXACT [GOC:mah] synonym: "regulation of filgrastim production" EXACT [GOC:mah] synonym: "regulation of G-CSF production" EXACT [GOC:mah] synonym: "regulation of granulocyte colony stimulating factor production" EXACT [] synonym: "regulation of lenograstim production" EXACT [GOC:mah] synonym: "regulation of pluripoietin production" EXACT [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0071611 ! granulocyte colony-stimulating factor production [Term] id: GO:0071656 name: negative regulation of granulocyte colony-stimulating factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor." [GOC:mah] synonym: "negative regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah] synonym: "negative regulation of CSF3 production" EXACT [GOC:mah] synonym: "negative regulation of filgrastim production" EXACT [GOC:mah] synonym: "negative regulation of G-CSF production" EXACT [GOC:mah] synonym: "negative regulation of granulocyte colony stimulating factor production" EXACT [] synonym: "negative regulation of lenograstim production" EXACT [GOC:mah] synonym: "negative regulation of pluripoietin production" EXACT [GOC:mah] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production relationship: negatively_regulates GO:0071611 ! granulocyte colony-stimulating factor production [Term] id: GO:0071657 name: positive regulation of granulocyte colony-stimulating factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah] synonym: "positive regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah] synonym: "positive regulation of CSF3 production" EXACT [GOC:mah] synonym: "positive regulation of filgrastim production" EXACT [GOC:mah] synonym: "positive regulation of G-CSF production" EXACT [GOC:mah] synonym: "positive regulation of granulocyte colony stimulating factor production" EXACT [] synonym: "positive regulation of lenograstim production" EXACT [GOC:mah] synonym: "positive regulation of pluripoietin production" EXACT [GOC:mah] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production relationship: positively_regulates GO:0071611 ! granulocyte colony-stimulating factor production [Term] id: GO:0071658 name: regulation of IP-10 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of IP-10." [GOC:mah] synonym: "regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah] synonym: "regulation of CXCL10 production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0071612 ! IP-10 production [Term] id: GO:0071659 name: negative regulation of IP-10 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of IP-10." [GOC:mah] synonym: "negative regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah] synonym: "negative regulation of CXCL10 production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071658 ! regulation of IP-10 production relationship: negatively_regulates GO:0071612 ! IP-10 production [Term] id: GO:0071660 name: positive regulation of IP-10 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of IP-10." [GOC:mah] synonym: "positive regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah] synonym: "positive regulation of CXCL10 production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071658 ! regulation of IP-10 production relationship: positively_regulates GO:0071612 ! IP-10 production [Term] id: GO:0071661 name: regulation of granzyme B production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of granzyme B." [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: regulates GO:0071613 ! granzyme B production [Term] id: GO:0071662 name: negative regulation of granzyme B production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granzyme B." [GOC:mah] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0071661 ! regulation of granzyme B production relationship: negatively_regulates GO:0071613 ! granzyme B production [Term] id: GO:0071663 name: positive regulation of granzyme B production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of granzyme B." [GOC:mah] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0071661 ! regulation of granzyme B production relationship: positively_regulates GO:0071613 ! granzyme B production [Term] id: GO:0071664 name: catenin-TCF7L2 complex namespace: cellular_component def: "A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054] subset: gosubset_prok synonym: "catenin-TCF4 complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0071665 name: gamma-catenin-TCF7L2 complex namespace: cellular_component def: "A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054] subset: gosubset_prok synonym: "gamma-catenin-TCF4 complex" EXACT [GOC:mah] synonym: "plakoglobin-TCF4 complex" EXACT [PMID:14661054] is_a: GO:0071664 ! catenin-TCF7L2 complex [Term] id: GO:0071666 name: Slit-Robo signaling complex namespace: cellular_component def: "A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766] synonym: "Slit-Robo signalling complex" EXACT [GOC:mah] is_a: GO:0032992 ! protein-carbohydrate complex [Term] id: GO:0071667 name: DNA/RNA hybrid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA/DNA hybrid." [GOC:ecd] synonym: "RNA/DNA hybrid binding" EXACT [GOC:ecd] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0071668 name: plant-type cell wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall." [GOC:mah] is_a: GO:0009664 ! plant-type cell wall organization is_a: GO:0070726 ! cell wall assembly relationship: part_of GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0071669 name: plant-type cell wall organization or biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [GOC:ecd, GOC:mah] synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0070882 ! cellular cell wall organization or biogenesis [Term] id: GO:0071670 name: smooth muscle cell chemotaxis namespace: biological_process def: "The directed movement of a smooth muscle cell in response to an external stimulus." [GOC:mah] is_a: GO:0014909 ! smooth muscle cell migration is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0071671 name: regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0050920 ! regulation of chemotaxis relationship: regulates GO:0071670 ! smooth muscle cell chemotaxis [Term] id: GO:0071672 name: negative regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] synonym: "down regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "down-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "downregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "inhibition of smooth muscle cell chemotaxis" NARROW [GOC:mah] is_a: GO:0014912 ! negative regulation of smooth muscle cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis relationship: negatively_regulates GO:0071670 ! smooth muscle cell chemotaxis [Term] id: GO:0071673 name: positive regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] synonym: "activation of smooth muscle cell chemotaxis" NARROW [GOC:mah] synonym: "stimulation of smooth muscle cell chemotaxis" NARROW [GOC:mah] synonym: "up regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "up-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "upregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] is_a: GO:0014911 ! positive regulation of smooth muscle cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis relationship: positively_regulates GO:0071670 ! smooth muscle cell chemotaxis [Term] id: GO:0071674 name: mononuclear cell migration namespace: biological_process def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] is_a: GO:0050900 ! leukocyte migration [Term] id: GO:0071675 name: regulation of mononuclear cell migration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] is_a: GO:0002685 ! regulation of leukocyte migration relationship: regulates GO:0071674 ! mononuclear cell migration [Term] id: GO:0071676 name: negative regulation of mononuclear cell migration namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0071675 ! regulation of mononuclear cell migration relationship: negatively_regulates GO:0071674 ! mononuclear cell migration [Term] id: GO:0071677 name: positive regulation of mononuclear cell migration namespace: biological_process def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] synonym: "activation of mononuclear cell migration" NARROW [GOC:mah] synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah] synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0071675 ! regulation of mononuclear cell migration relationship: positively_regulates GO:0071674 ! mononuclear cell migration [Term] id: GO:0071678 name: olfactory bulb axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah] synonym: "olfactory bulb axon pathfinding" EXACT [GOC:vk] is_a: GO:0007411 ! axon guidance [Term] id: GO:0071679 name: commissural neuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah] synonym: "commissural neuron axon pathfinding" EXACT [GOC:vk] is_a: GO:0007411 ! axon guidance [Term] id: GO:0071680 name: response to indole-3-methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [CHEBI:24814, GOC:mah] synonym: "response to indole-3-carbinol" EXACT [CHEBI:24814] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0071681 name: cellular response to indole-3-methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [CHEBI:24814, GOC:mah] synonym: "cellular response to indole-3-carbinol" EXACT [CHEBI:24814] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071680 ! response to indole-3-methanol [Term] id: GO:0071682 name: endocytic vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde] is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen relationship: part_of GO:0030139 ! endocytic vesicle [Term] id: GO:0071683 name: sensory dendrite namespace: cellular_component def: "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah] is_a: GO:0030425 ! dendrite [Term] id: GO:0071684 name: organism emergence from protective structure namespace: biological_process def: "The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case." [GOC:mah] is_a: GO:0032502 ! developmental process [Term] id: GO:0071685 name: NADH dehydrogenase complex (plastoquinone) namespace: cellular_component def: "An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids." [DOI:10.1078/0176-1617-00593, GOC:mah] is_a: GO:0030964 ! NADH dehydrogenase complex is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0031976 ! plastid thylakoid [Term] id: GO:0071686 name: horsetail nucleus namespace: cellular_component def: "The elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:vw, PMID:15030757] is_a: GO:0005634 ! nucleus [Term] id: GO:0071687 name: horsetail nucleus leading edge namespace: cellular_component def: "The part of the horsetail nucleus where telomeres cluster under the SPB and that leads horsetail movement. The horsetail nucleus is the elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:mah, GOC:vw, PMID:15030757] is_a: GO:0044428 ! nuclear part relationship: part_of GO:0071686 ! horsetail nucleus [Term] id: GO:0071688 name: striated muscle myosin thick filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle." [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0031034 ! myosin filament assembly relationship: part_of GO:0030239 ! myofibril assembly [Term] id: GO:0071689 name: muscle thin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle." [GOC:mah] is_a: GO:0007015 ! actin filament organization relationship: part_of GO:0030239 ! myofibril assembly [Term] id: GO:0071690 name: cardiac muscle myosin thick filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle." [GOC:mah] is_a: GO:0071688 ! striated muscle myosin thick filament assembly relationship: part_of GO:0055003 ! cardiac myofibril assembly [Term] id: GO:0071691 name: cardiac muscle thin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle." [GOC:mah] is_a: GO:0007015 ! actin filament organization relationship: part_of GO:0055003 ! cardiac myofibril assembly [Term] id: GO:0071692 name: protein localization in extracellular region namespace: biological_process def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] synonym: "protein localisation in extracellular region" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization [Term] id: GO:0071693 name: protein transport within extracellular region namespace: biological_process def: "The directed movement of proteins in the extracellular region, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015031 ! protein transport is_a: GO:0035592 ! establishment of protein localization in extracellular region [Term] id: GO:0071694 name: maintenance of protein location in extracellular region namespace: biological_process def: "Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization to organelle relationship: part_of GO:0071692 ! protein localization in extracellular region [Term] id: GO:0071695 name: anatomical structure maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] is_a: GO:0021700 ! developmental maturation relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0071696 name: ectodermal placode development namespace: biological_process def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0071697 name: ectodermal placode morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0071696 ! ectodermal placode development [Term] id: GO:0071698 name: olfactory placode development namespace: biological_process def: "The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] is_a: GO:0071696 ! ectodermal placode development [Term] id: GO:0071699 name: olfactory placode morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0071697 ! ectodermal placode morphogenesis relationship: part_of GO:0071698 ! olfactory placode development [Term] id: GO:0071700 name: olfactory placode maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory placode to attain its fully functional state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0071698 ! olfactory placode development [Term] id: GO:0071701 name: regulation of MAPK export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:dgf] synonym: "regulation of cytoplasmic translocation of MAP kinase" EXACT [GOC:mah] synonym: "regulation of cytoplasmic translocation of mitogen-activated protein kinase" EXACT [GOC:mah] synonym: "regulation of MAPK export from cell nucleus" EXACT [GOC:mah] synonym: "regulation of MAPK export out of nucleus" EXACT [GOC:mah] synonym: "regulation of MAPK transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "regulation of MAPK-nucleus export" EXACT [GOC:mah] is_a: GO:0046825 ! regulation of protein export from nucleus relationship: regulates GO:0045204 ! MAPK export from nucleus [Term] id: GO:0071702 name: organic substance transport namespace: biological_process def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [CHEBI:50860, GOC:mah] is_a: GO:0006810 ! transport [Term] id: GO:0071703 name: detection of organic substance namespace: biological_process def: "The series of events in which an organic substance stimulus is received by a cell and converted into a molecular signal." [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0071704 name: organic substance metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic substances, any molecular entities containing carbon." [CHEBI:50860, GOC:mah] is_a: GO:0008152 ! metabolic process [Term] id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:51143, GOC:mah] is_a: GO:0006810 ! transport [Term] id: GO:0071706 name: tumor necrosis factor superfamily cytokine production namespace: biological_process def: "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add] synonym: "TNF superfamily production" RELATED [GOC:rv] synonym: "TNFSF cytokine production" EXACT [GOC:add] is_a: GO:0001816 ! cytokine production [Term] id: GO:0071707 name: immunoglobulin heavy chain V-D-J recombination namespace: biological_process def: "The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149] synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add] synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add] synonym: "immunoglobulin V-D-J joining" EXACT [GOC:add] is_a: GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: GO:0071708 name: immunoglobulin light chain V-J recombination namespace: biological_process def: "The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149] synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add] synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add] synonym: "immunoglobulin V-J joining" EXACT [GOC:add] is_a: GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: GO:0071709 name: membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah] is_a: GO:0016044 ! cellular membrane organization is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0044091 ! membrane biogenesis [Term] id: GO:0071710 name: membrane macromolecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a membrane in a cell." [GOC:mah] synonym: "membrane macromolecule anabolism" EXACT [GOC:mah] synonym: "membrane macromolecule biosynthesis" EXACT [GOC:mah] synonym: "membrane macromolecule formation" EXACT [GOC:mah] synonym: "membrane macromolecule synthesis" EXACT [GOC:mah] is_a: GO:0070589 ! cellular component macromolecule biosynthetic process relationship: part_of GO:0044091 ! membrane biogenesis [Term] id: GO:0071711 name: basement membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah] comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. is_a: GO:0030198 ! extracellular matrix organization [Term] id: GO:0071712 name: ER-associated misfolded protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:vw, PMID:14607247, PMID:19520858] comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. synonym: "endoplasmic reticulum-associated misfolded protein catabolic process" EXACT [GOC:mah] synonym: "endoplasmic reticulum-associated misfolded protein catabolism" EXACT [GOC:mah] synonym: "ER-associated misfolded protein breakdown" EXACT [GOC:mah] synonym: "ER-associated misfolded protein catabolism" EXACT [GOC:mah] synonym: "ER-associated misfolded protein degradation" EXACT [GOC:mah] is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process is_a: GO:0030433 ! ER-associated protein catabolic process is_a: GO:0071218 ! cellular response to misfolded protein [Term] id: GO:0071713 name: para-aminobenzoyl-glutamate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate." [GOC:imk, PMID:20190044] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0071714 name: icosanoid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of icosanoids from one side of the membrane to the other." [GOC:sl] synonym: "eicosanoid transmembrane transporter activity" EXACT [GOC:sl] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015245 ! fatty acid transporter activity [Term] id: GO:0071715 name: icosanoid transport namespace: biological_process def: "The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [CHEBI:23899, GOC:mah] synonym: "eicosanoid transport" EXACT [GOC:sl] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0071716 name: leukotriene transport namespace: biological_process def: "The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [CHEBI:25029, GOC:mah] is_a: GO:0071715 ! icosanoid transport [Term] id: GO:0071717 name: thromboxane transport namespace: biological_process def: "The directed movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [CHEBI:26995, GOC:mah] is_a: GO:0071715 ! icosanoid transport [Term] id: GO:0071718 name: sodium-independent icosanoid transport namespace: biological_process def: "The directed, sodium-independent, movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [CHEBI:23899, GOC:mah, GOC:sl] synonym: "sodium-independent eicosanoid transport" EXACT [GOC:sl] is_a: GO:0071715 ! icosanoid transport [Term] id: GO:0071719 name: sodium-independent leukotriene transport namespace: biological_process def: "The directed, sodium-independent, movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [CHEBI:25029, GOC:mah] is_a: GO:0071716 ! leukotriene transport is_a: GO:0071718 ! sodium-independent icosanoid transport [Term] id: GO:0071720 name: sodium-independent prostaglandin transport namespace: biological_process def: "The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015732 ! prostaglandin transport is_a: GO:0071718 ! sodium-independent icosanoid transport [Term] id: GO:0071721 name: sodium-independent thromboxane transport namespace: biological_process def: "The directed, sodium-independent, movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [CHEBI:26995, GOC:mah] is_a: GO:0071717 ! thromboxane transport is_a: GO:0071718 ! sodium-independent icosanoid transport [Term] id: GO:0071722 name: detoxification of arsenic-containing substance namespace: biological_process def: "Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds." [GOC:kmv, PMID:11313333, PMID:20221439] synonym: "detoxification of arsenic" EXACT [GOC:curators] is_a: GO:0009636 ! response to toxin is_a: GO:0046685 ! response to arsenic-containing substance [Term] id: GO:0071723 name: lipopeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "bacterial lipopeptide binding" NARROW [GOC:add] synonym: "bacterial lipoprotein binding" RELATED [GOC:add] is_a: GO:0042277 ! peptide binding [Term] id: GO:0071724 name: response to diacyl bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "response to diacylated bacterial lipoprotein" EXACT [GOC:add] is_a: GO:0070339 ! response to bacterial lipopeptide [Term] id: GO:0071725 name: response to triacyl bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "response to triacylated bacterial lipoprotein" EXACT [GOC:add] is_a: GO:0070339 ! response to bacterial lipopeptide [Term] id: GO:0071726 name: cellular response to diacyl bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "cellular response to diacylated bacterial lipoprotein" EXACT [GOC:add] is_a: GO:0071221 ! cellular response to bacterial lipopeptide is_a: GO:0071724 ! response to diacyl bacterial lipopeptide [Term] id: GO:0071727 name: cellular response to triacyl bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "cellular response to triacylated bacterial lipoprotein" EXACT [GOC:add] is_a: GO:0071221 ! cellular response to bacterial lipopeptide is_a: GO:0071725 ! response to triacyl bacterial lipopeptide [Term] id: GO:0071728 name: beak development namespace: biological_process def: "The progression of the beak over time from its initial formation until its mature state. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary ramaphotheca, mandibular ramaphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0071729 name: beak morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the beak are generated and organized. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary ramaphotheca, mandibular ramaphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0071728 ! beak development [Term] id: GO:0071730 name: beak formation namespace: biological_process def: "The process that gives rise to the beak. This process pertains to the initial formation of a structure from unspecified parts. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary ramaphotheca, mandibular ramaphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0071729 ! beak morphogenesis [Term] id: GO:0071731 name: response to nitric oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0071732 name: cellular response to nitric oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah] is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0071731 ! response to nitric oxide [Term] id: GO:0071733 name: transcriptional activation by promoter-enhancer looping namespace: biological_process def: "The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:mah, PMID:15060134, PMID:19923429] synonym: "long-range enhancer-promoter communication" RELATED [PMID:15060134] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0090202 ! gene looping [Term] id: GO:0071734 name: biotin-[pyruvate-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase)." [GOC:mah, PMID:10551847] synonym: "biotin-[pyruvate carboxylase] ligase activity" EXACT [GOC:jp] synonym: "biotin-[pyruvate carboxylase] synthetase activity" EXACT [GOC:mah] synonym: "biotin-pyruvate carboxylase synthetase activity" EXACT [GOC:mah] synonym: "biotin-pyruvate-carboxylase ligase activity" EXACT [GOC:mah] synonym: "biotin:apo-pyruvate-carboxylase ligase" EXACT [GOC:mah] xref: EC:6.3.4.- is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0071735 name: IgG immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. synonym: "IgG1" NARROW [GOC:add] synonym: "IgG2" NARROW [GOC:add] synonym: "IgG2a" NARROW [GOC:add] synonym: "IgG2b" NARROW [GOC:add] synonym: "IgG2c" NARROW [GOC:add] synonym: "IgG3" NARROW [GOC:add] synonym: "IgG4" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071736 name: IgG immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. synonym: "IgG antibody" NARROW [GOC:add] synonym: "IgG1 antibody" NARROW [GOC:add] synonym: "IgG2 antibody" NARROW [GOC:add] synonym: "IgG2a antibody" NARROW [GOC:add] synonym: "IgG2b antibody" NARROW [GOC:add] synonym: "IgG2c antibody" NARROW [GOC:add] synonym: "IgG3 antibody" NARROW [GOC:add] synonym: "IgG4 antibody" NARROW [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071735 ! IgG immunoglobulin complex [Term] id: GO:0071737 name: IgG B cell receptor complex namespace: cellular_component def: "An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196] comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. synonym: "membrane-bound IgG" NARROW [GOC:add] synonym: "membrane-bound IgG1" NARROW [GOC:add] synonym: "membrane-bound IgG2" NARROW [GOC:add] synonym: "membrane-bound IgG2a" NARROW [GOC:add] synonym: "membrane-bound IgG2b" NARROW [GOC:add] synonym: "membrane-bound IgG2c" NARROW [GOC:add] synonym: "membrane-bound IgG3" NARROW [GOC:add] synonym: "membrane-bound IgG4" NARROW [GOC:add] synonym: "surface IgG" NARROW [GOC:add] synonym: "surface IgG1" NARROW [GOC:add] synonym: "surface IgG2" NARROW [GOC:add] synonym: "surface IgG2a" NARROW [GOC:add] synonym: "surface IgG2b" NARROW [GOC:add] synonym: "surface IgG2c" NARROW [GOC:add] synonym: "surface IgG3" NARROW [GOC:add] synonym: "surface IgG4" NARROW [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071735 ! IgG immunoglobulin complex [Term] id: GO:0071738 name: IgD immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071739 name: IgD immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgD antibody" EXACT [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071738 ! IgD immunoglobulin complex [Term] id: GO:0071740 name: IgD B cell receptor complex namespace: cellular_component def: "An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "membrane-bound IgD" EXACT [GOC:add] synonym: "surface IgD" EXACT [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071738 ! IgD immunoglobulin complex [Term] id: GO:0071741 name: IgD immunoglobulin complex, GPI-anchored namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "GPI-anchored IgD" EXACT [GOC:add] is_a: GO:0071738 ! IgD immunoglobulin complex [Term] id: GO:0071742 name: IgE immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071743 name: IgE immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgE antibody" EXACT [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071742 ! IgE immunoglobulin complex [Term] id: GO:0071744 name: IgE B cell receptor complex namespace: cellular_component def: "An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196] comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "membrane-bound IgE" EXACT [GOC:add] synonym: "surface IgE" EXACT [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071742 ! IgE immunoglobulin complex [Term] id: GO:0071745 name: IgA immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgA1 antibody" NARROW [GOC:add] synonym: "IgA2 antibody" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071746 name: IgA immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgA antibody" EXACT [GOC:add] synonym: "IgA1 antibody" NARROW [GOC:add] synonym: "IgA2 antibody" NARROW [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071745 ! IgA immunoglobulin complex [Term] id: GO:0071747 name: IgA B cell receptor complex namespace: cellular_component def: "An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "membrane-bound IgA" NARROW [GOC:add] synonym: "membrane-bound IgA1" NARROW [GOC:add] synonym: "membrane-bound IgA2" NARROW [GOC:add] synonym: "surface IgA" NARROW [GOC:add] synonym: "surface IgA1" NARROW [GOC:add] synonym: "surface IgA2" NARROW [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071745 ! IgA immunoglobulin complex [Term] id: GO:0071748 name: monomeric IgA immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "monomeric IgA antibody" EXACT [GOC:add] synonym: "monomeric IgA1 antibody" NARROW [GOC:add] synonym: "monomeric IgA2 antibody" NARROW [GOC:add] is_a: GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: GO:0071749 name: polymeric IgA immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a polymeric forms. synonym: "pIgA antibody" EXACT [GOC:add] synonym: "pIgA1 antibody" NARROW [GOC:add] synonym: "polymeric IgA antibody" EXACT [GOC:add] synonym: "polymeric IgA1 antibody" NARROW [GOC:add] is_a: GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: GO:0071750 name: dimeric IgA immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form. synonym: "dimeric IgA antibody" EXACT [GOC:add] synonym: "dimeric IgA1 antibody" NARROW [GOC:add] is_a: GO:0071749 ! polymeric IgA immunoglobulin complex [Term] id: GO:0071751 name: secretory IgA immunoglobulin complex namespace: cellular_component def: "A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA. synonym: "secretory IgA antibody" EXACT [GOC:add] synonym: "sIgA antibody" EXACT [GOC:add] synonym: "sIgA1 antibody" NARROW [GOC:add] is_a: GO:0071749 ! polymeric IgA immunoglobulin complex [Term] id: GO:0071752 name: secretory dimeric IgA immunoglobulin complex namespace: cellular_component def: "A dimeric form of secretory IgA immunoglobulin complex." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form. synonym: "secretory dimeric IgA antibody" EXACT [GOC:add] synonym: "secretory dimeric IgA1 antibody" NARROW [GOC:add] is_a: GO:0071750 ! dimeric IgA immunoglobulin complex is_a: GO:0071751 ! secretory IgA immunoglobulin complex [Term] id: GO:0071753 name: IgM immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071754 name: IgM immunoglobulin complex, circulating namespace: cellular_component def: "A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgM antibody" EXACT [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071753 ! IgM immunoglobulin complex [Term] id: GO:0071755 name: IgM B cell receptor complex namespace: cellular_component def: "An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "membrane-bound IgM" NARROW [GOC:add] synonym: "surface IgM" NARROW [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071753 ! IgM immunoglobulin complex [Term] id: GO:0071756 name: pentameric IgM immunoglobulin complex namespace: cellular_component def: "A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "pentameric IgM antibody" EXACT [GOC:add] is_a: GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: GO:0071757 name: hexameric IgM immunoglobulin complex namespace: cellular_component def: "A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "hexameric IgM antibody" EXACT [GOC:add] is_a: GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: GO:0071758 name: IgW immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgW immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgW is found in fish. is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071759 name: IgX immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgX isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgX immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgX immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgX is found in amphibians. is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071760 name: IgY immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgY immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgY is found in amphibians, reptiles, and birds. is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071761 name: IgZ immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish." [GOC:add, ISBN:0781765196] comment: Note that an IgZ immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgZ is found in bony fish, and called IgT in certain species, such as trout. synonym: "IgT antibody" NARROW [GOC:add] synonym: "IgT immunoglobulin complex" EXACT [ISBN:0781765196] synonym: "IgZ antibody" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071762 name: heavy chain immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains." [GOC:add, ISBN:0781765196, PMID:12543123, PMID:16051357] comment: Note that a heavy chain immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgNAR is found in serum of cartilaginous fish as a heavy chain dimer without immunoglobulin light chains. Note that HCab is found in camels as a heavy chain dimer without immunoglobulin light chains. synonym: "HCab" NARROW [GOC:add] synonym: "Ig NAR immunoglobulin complex" NARROW [GOC:add] synonym: "IgNAR antibody" NARROW [GOC:add] synonym: "IgNAR immunoglobulin complex" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071763 name: nuclear membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah] synonym: "nuclear membrane organisation" EXACT [GOC:mah] synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0006998 ! nuclear envelope organization [Term] id: GO:0071764 name: nuclear outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah] synonym: "nuclear outer membrane organisation" EXACT [GOC:mah] synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071763 ! nuclear membrane organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0071765 name: nuclear inner membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane." [GOC:mah] synonym: "nuclear inner membrane organisation" EXACT [GOC:mah] synonym: "nuclear inner membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071763 ! nuclear membrane organization [Term] id: GO:0071766 name: Actinobacterium-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Actinobacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. Actinobacterial cell walls contain characteristic mycolic acids, of which some are covalently linked to the cell wall peptidoglycan and others accumulate at the cell surface." [GOC:mah, PMID:15653820, PMID:3149973] subset: gosubset_prok is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0071767 name: mycolic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, PMID:15653820] synonym: "mycolate metabolic process" EXACT [GOC:mah] synonym: "mycolic acid metabolism" EXACT [GOC:mah] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0071768 name: mycolic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, MetaCyc:PWYG-321, PMID:15653820] synonym: "mycolate biosynthetic process" EXACT [GOC:mah] synonym: "mycolic acid anabolism" EXACT [GOC:mah] synonym: "mycolic acid biosynthesis" EXACT [GOC:mah] synonym: "mycolic acid formation" EXACT [GOC:mah] synonym: "mycolic acid synthesis" EXACT [GOC:mah] xref: MetaCyc:PWYG-321 is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process is_a: GO:0071767 ! mycolic acid metabolic process relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis [Term] id: GO:0071769 name: mycolate cell wall layer assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer." [GOC:mah, MetaCyc:PWY-6397, PMID:15653820, PMID:3149973] synonym: "mycolate cell wall layer biogenesis" RELATED [GOC:mah] xref: MetaCyc:PWY-6397 is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis [Term] id: GO:0071770 name: DIM/DIP cell wall layer assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components, including (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate and diphthioceranate, to form the DIM/DIP layer of the Actinobacterium-type cell wall." [GOC:mah, PMID:15653820, PMID:3149973] synonym: "DIM cell wall layer assembly" EXACT [GOC:mah] synonym: "DIM/DIP cell wall layer biogenesis" RELATED [GOC:mah] synonym: "PDIM cell wall layer assembly" EXACT [GOC:mah] is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis [Term] id: GO:0071771 name: aldehyde decarbonylase activity namespace: molecular_function def: "Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO." [GOC:kad, PMID:6593720, PMID:8718622] synonym: "decarbonylase activity" EXACT [EC:4.1.99.5, GOC:kad, GOC:mah] xref: EC:4.1.99.- is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0071772 name: response to BMP stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah] synonym: "response to bone morphogenetic protein stimulus" EXACT [GOC:mah] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor stimulus [Term] id: GO:0071773 name: cellular response to BMP stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah] synonym: "cellular response to bone morphogenetic protein stimulus" EXACT [GOC:mah] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:0071772 ! response to BMP stimulus [Term] id: GO:0071774 name: response to fibroblast growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus." [GOC:mah] synonym: "response to FGF stimulus" EXACT [GOC:mah] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor stimulus [Term] id: GO:0071775 name: regulation of cell cycle cytokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells, that occurs in the context of cell cycle progression." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0032465 ! regulation of cytokinesis relationship: regulates GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0071776 name: negative regulation of cell cycle cytokinesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells, that occurs in the context of cell cycle progression." [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:0071775 ! regulation of cell cycle cytokinesis relationship: negatively_regulates GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0071777 name: positive regulation of cell cycle cytokinesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells, that occurs in the context of cell cycle progression." [GOC:mah] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:0071775 ! regulation of cell cycle cytokinesis is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0071778 name: WINAC complex namespace: cellular_component def: "A SWI/SNF-type complex that directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF), and mediates the recruitment of unliganded VDR to VDR target sites in promoters. The WINAC complex contains at least 13 subunits, including WSTF, several SWI/SNF components, and DNA replication-related factors." [GOC:BHF, PMID:12837248] is_a: GO:0070603 ! SWI/SNF-type complex [Term] id: GO:0071779 name: G1/S transition checkpoint namespace: biological_process def: "A cell cycle checkpoint that blocks entry into S phase." [GOC:mah] synonym: "G1/S checkpoint" EXACT [] is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0071780 name: mitotic cell cycle G2/M transition checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that blocks entry into M phase." [GOC:mah] synonym: "mitotic G2/M checkpoint" EXACT [GOC:mah] is_a: GO:0000086 ! G2/M transition of mitotic cell cycle is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle is_a: GO:0031576 ! G2/M transition checkpoint [Term] id: GO:0071781 name: endoplasmic reticulum cisternal network namespace: cellular_component def: "An endoplasmic reticulum part that comprises the membranes with low curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] synonym: "ER cisternal network" EXACT [GOC:mah] is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0071782 name: endoplasmic reticulum tubular network namespace: cellular_component def: "An endoplasmic reticulum part that comprises the membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] synonym: "ER tubular network" EXACT [GOC:mah] is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0071783 name: endoplasmic reticulum cisternal network organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] synonym: "endoplasmic reticulum cisternal network organisation" EXACT [GOC:mah] synonym: "ER cisternal network organisation" EXACT [GOC:mah] synonym: "ER cisternal network organization" EXACT [GOC:mah] is_a: GO:0007029 ! endoplasmic reticulum organization [Term] id: GO:0071784 name: endoplasmic reticulum cisternal network assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] synonym: "endoplasmic reticulum cisternal network formation" EXACT [GOC:mah] synonym: "ER cisternal network assembly" EXACT [GOC:mah] synonym: "ER cisternal network formation" EXACT [GOC:mah] is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0071785 name: endoplasmic reticulum cisternal network maintenance namespace: biological_process def: "The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] synonym: "ER cisternal network maintenance" EXACT [GOC:mah] is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization is_a: GO:0071956 ! cellular component maintenance at cellular level [Term] id: GO:0071786 name: endoplasmic reticulum tubular network organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] synonym: "endoplasmic reticulum tubular network organisation" EXACT [GOC:mah] synonym: "ER tubular network organisation" EXACT [GOC:mah] synonym: "ER tubular network organization" EXACT [GOC:mah] is_a: GO:0007029 ! endoplasmic reticulum organization [Term] id: GO:0071787 name: endoplasmic reticulum tubular network assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] synonym: "endoplasmic reticulum tubular network formation" EXACT [GOC:mah] synonym: "ER tubular network assembly" EXACT [GOC:mah] synonym: "ER tubular network formation" EXACT [GOC:mah] is_a: GO:0071786 ! endoplasmic reticulum tubular network organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0071788 name: endoplasmic reticulum tubular network maintenance namespace: biological_process def: "The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] synonym: "ER tubular network maintenance" EXACT [GOC:mah] is_a: GO:0071786 ! endoplasmic reticulum tubular network organization is_a: GO:0071956 ! cellular component maintenance at cellular level [Term] id: GO:0071789 name: spindle pole body localization in nuclear envelope namespace: biological_process def: "A process in which a spindle pole body is transported to, or maintained in, a specific location in the nuclear envelope. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah, PMID:20434336] synonym: "spindle pole body anchorage" EXACT [GOC:vw] synonym: "spindle pole body docking" EXACT [GOC:vw] synonym: "spindle pole body localisation in nuclear envelope" EXACT [GOC:mah] is_a: GO:0070631 ! spindle pole body localization [Term] id: GO:0071790 name: establishment of spindle pole body localization in nuclear envelope namespace: biological_process def: "A process in which a spindle pole body is transported to a specific location in the nuclear envelope. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah, PMID:20434336] synonym: "establishment of spindle pole body localisation in nuclear envelope" EXACT [GOC:mah] is_a: GO:0070632 ! establishment of spindle pole body localization is_a: GO:0071789 ! spindle pole body localization in nuclear envelope [Term] id: GO:0071791 name: chemokine (C-C motif) ligand 5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 5." [GOC:add, GOC:amm] synonym: "CCL5 binding" EXACT [GOC:add, GOC:amm] synonym: "RANTES binding" EXACT [GOC:bf] synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted binding" EXACT [GOC:add] is_a: GO:0019957 ! C-C chemokine binding [Term] id: GO:0071792 name: bacillithiol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541] subset: gosubset_prok synonym: "bacillithiol metabolism" EXACT [GOC:mah] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0071793 name: bacillithiol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541] subset: gosubset_prok synonym: "bacillithiol anabolism" EXACT [GOC:mah] synonym: "bacillithiol biosynthesis" EXACT [GOC:mah] synonym: "bacillithiol formation" EXACT [GOC:mah] synonym: "bacillithiol synthesis" EXACT [GOC:mah] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0071792 ! bacillithiol metabolic process [Term] id: GO:0071794 name: CAP-Gly domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets." [GOC:mah, InterPro:IPR000938] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0071795 name: K11-linked polyubiquitin binding namespace: molecular_function def: "Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers." [GOC:sp, PMID:18775313] is_a: GO:0031593 ! polyubiquitin binding [Term] id: GO:0071796 name: K6-linked polyubiquitin binding namespace: molecular_function def: "Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers." [GOC:sp, PMID:17525341, PMID:20351172] is_a: GO:0031593 ! polyubiquitin binding [Term] id: GO:0071797 name: LUBAC complex namespace: cellular_component def: "A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex." [GOC:sp, PMID:17006537, PMID:19136968, PMID:21455180] is_a: GO:0000151 ! ubiquitin ligase complex [Term] id: GO:0071798 name: response to prostaglandin D stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl] is_a: GO:0034694 ! response to prostaglandin stimulus [Term] id: GO:0071799 name: cellular response to prostaglandin D stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl] is_a: GO:0071379 ! cellular response to prostaglandin stimulus is_a: GO:0071798 ! response to prostaglandin D stimulus [Term] id: GO:0071800 name: podosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell." [GOC:mah, GOC:sl] is_a: GO:0006461 ! protein complex assembly [Term] id: GO:0071801 name: regulation of podosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of podosome assembly." [GOC:mah, GOC:sl] comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. is_a: GO:0043254 ! regulation of protein complex assembly relationship: regulates GO:0071800 ! podosome assembly [Term] id: GO:0071802 name: negative regulation of podosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of podosome assembly." [GOC:mah, GOC:sl] synonym: "down regulation of podosome assembly" EXACT [GOC:mah] synonym: "down-regulation of podosome assembly" EXACT [GOC:mah] synonym: "downregulation of podosome assembly" EXACT [GOC:mah] synonym: "inhibition of podosome assembly" NARROW [GOC:mah] is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0071801 ! regulation of podosome assembly relationship: negatively_regulates GO:0071800 ! podosome assembly [Term] id: GO:0071803 name: positive regulation of podosome assembly namespace: biological_process def: "Any process that activates or increases the rate or extent of podosome assembly." [GOC:mah, GOC:sl] synonym: "activation of podosome assembly" NARROW [GOC:mah] synonym: "stimulation of podosome assembly" NARROW [GOC:mah] synonym: "up regulation of podosome assembly" EXACT [GOC:mah] synonym: "up-regulation of podosome assembly" EXACT [GOC:mah] synonym: "upregulation of podosome assembly" EXACT [GOC:mah] is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0071801 ! regulation of podosome assembly relationship: positively_regulates GO:0071800 ! podosome assembly [Term] id: GO:0071804 name: cellular potassium ion transport namespace: biological_process def: "The directed movement of potassium (K) ions into, out of, or within a cell." [GOC:mah, GOC:vw] is_a: GO:0006813 ! potassium ion transport is_a: GO:0009987 ! cellular process [Term] id: GO:0071805 name: potassium ion transmembrane transport namespace: biological_process def: "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] is_a: GO:0034220 ! ion transmembrane transport is_a: GO:0071804 ! cellular potassium ion transport [Term] id: GO:0071806 name: protein transmembrane transport namespace: biological_process def: "The directed movement of a protein across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:vw] is_a: GO:0015031 ! protein transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0071807 name: replication fork arrest involved in DNA replication termination namespace: biological_process def: "A replication fork arrest process that contributes to the termination of DNA replication." [GOC:mah, PMID:17347517, PMID:20797631] is_a: GO:0043111 ! replication fork arrest relationship: part_of GO:0006274 ! DNA replication termination [Term] id: GO:0071808 name: satellite fibril namespace: cellular_component def: "An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section)." [GOC:mah, GOC:sl, PMID:20108326] is_a: GO:0044447 ! axoneme part [Term] id: GO:0071809 name: regulation of fever generation by regulation of prostaglandin biosynthesis namespace: biological_process def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah] is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process is_a: GO:0031620 ! regulation of fever generation [Term] id: GO:0071810 name: regulation of fever generation by regulation of prostaglandin secretion namespace: biological_process def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:BHF, GOC:dph, GOC:mah] is_a: GO:0031620 ! regulation of fever generation is_a: GO:0032306 ! regulation of prostaglandin secretion [Term] id: GO:0071811 name: positive regulation of fever generation by positive regulation of prostaglandin biosynthesis namespace: biological_process def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah] is_a: GO:0031394 ! positive regulation of prostaglandin biosynthetic process is_a: GO:0031622 ! positive regulation of fever generation is_a: GO:0071809 ! regulation of fever generation by regulation of prostaglandin biosynthesis [Term] id: GO:0071812 name: positive regulation of fever generation by positive regulation of prostaglandin secretion namespace: biological_process def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:BHF, GOC:dph, GOC:mah] is_a: GO:0031622 ! positive regulation of fever generation is_a: GO:0032308 ! positive regulation of prostaglandin secretion is_a: GO:0071810 ! regulation of fever generation by regulation of prostaglandin secretion [Term] id: GO:0071813 name: lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [CHEBI:6495, GOC:BHF, GOC:mah] synonym: "lipoprotein binding" RELATED [GOC:mah] synonym: "plasma lipoprotein binding" RELATED [GOC:mah] synonym: "plasma lipoprotein particle binding" EXACT [GOC:mah] is_a: GO:0071814 ! protein-lipid complex binding [Term] id: GO:0071814 name: protein-lipid complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules." [GOC:BHF, GOC:mah] is_a: GO:0005488 ! binding [Term] id: GO:0071815 name: intermediate-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm." [GOC:BHF, GOC:mah] synonym: "IDL binding" EXACT [GOC:BHF] synonym: "intermediate-density lipoprotein binding" EXACT [GOC:dph] is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0071816 name: tail-anchored membrane protein insertion into ER membrane namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083] synonym: "protein insertion of tail-anchored membrane proteins into ER membrane" EXACT [GOC:sp] synonym: "tail-anchored membrane protein insertion into endoplasmic reticulum membrane" EXACT [GOC:mah] synonym: "type II transmembrane protein insertion into ER membrane" EXACT [GOC:mah, GOC:sp] is_a: GO:0045048 ! protein insertion into ER membrane [Term] id: GO:0071817 name: MMXD complex namespace: cellular_component def: "A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation." [GOC:sp, PMID:20797633] synonym: "MMS19-MIP18-XPD complex" EXACT [GOC:sp, PMID:20797633] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle [Term] id: GO:0071818 name: BAT3 complex namespace: cellular_component def: "An ER membrane insertion complex that acts by facilitating tail-anchored protein capture by ASNA1/TRC40. In mammals the complex contains Bat3, TRC35 and Ubl4A." [GOC:mah, GOC:sp, PMID:20676083] is_a: GO:0072379 ! ER membrane insertion complex [Term] id: GO:0071819 name: DUBm complex namespace: cellular_component def: "A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473] synonym: "deubiquitinating module" EXACT [GOC:jp, PMID:20395473] synonym: "deubiquitination module" EXACT [PMID:19226466] synonym: "SAGA DUBm complex" NARROW [GOC:jp] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071820 name: N-box binding namespace: molecular_function def: "Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses." [GOC:yaf, PMID:11498047] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "N box binding" EXACT [GOC:mah] synonym: "N-box promoter binding" EXACT [GOC:mah] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0071821 name: FANCM-MHF complex namespace: cellular_component def: "A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes." [GOC:mah, GOC:vw, PMID:20347428] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0071822 name: protein complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0071823 name: protein-carbohydrate complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex." [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0071824 name: protein-DNA complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah] synonym: "DNA-protein complex subunit organization" EXACT [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0071825 name: protein-lipid complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex." [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0071826 name: ribonucleoprotein complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah] synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0071827 name: plasma lipoprotein particle organization namespace: biological_process def: "A protein-lipid complex subunit organization process that results in the formation, disassembly, or alteration of a plasma lipoprotein particle. A plasma lipoprotein particle is a spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins." [GOC:BHF, GOC:mah] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0071825 ! protein-lipid complex subunit organization [Term] id: GO:0071828 name: apolipoprotein E recycling namespace: biological_process def: "The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle." [GOC:BHF, PMID:16373604] synonym: "APOE recycling" EXACT [GOC:BHF] is_a: GO:0015031 ! protein transport relationship: part_of GO:0034380 ! high-density lipoprotein particle assembly relationship: part_of GO:0034382 ! chylomicron remnant clearance [Term] id: GO:0071829 name: plasma lipoprotein particle disassembly namespace: biological_process def: "The disaggregation of a plasma lipoprotein particle into its constituent components." [GOC:mah] is_a: GO:0032987 ! protein-lipid complex disassembly is_a: GO:0071827 ! plasma lipoprotein particle organization relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels [Term] id: GO:0071830 name: triglyceride-rich lipoprotein particle clearance namespace: biological_process def: "The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF] is_a: GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0071831 name: intermediate-density lipoprotein particle clearance namespace: biological_process def: "The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF] synonym: "IDL clearance" EXACT [GOC:BHF] is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance [Term] id: GO:0071832 name: peptide pheromone export involved in conjugation namespace: biological_process def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh, GOC:jh, GOC:mah] is_a: GO:0000770 ! peptide pheromone export relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0071833 name: peptide pheromone export involved in conjugation with cellular fusion namespace: biological_process def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh, GOC:jh, GOC:mah] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0071832 ! peptide pheromone export involved in conjugation relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0071834 name: mating pheromone secretion namespace: biological_process def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction." [GOC:mah] synonym: "mating-type pheromone secretion" EXACT [GOC:vw] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0071835 name: mating pheromone secretion involved in conjugation namespace: biological_process def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh, GOC:jh, GOC:mah] synonym: "mating-type pheromone secretion involved in conjugation" EXACT [GOC:mah, GOC:vw] is_a: GO:0071834 ! mating pheromone secretion relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0071836 name: nectar secretion namespace: biological_process def: "The controlled release of a nectar by a cell, a group of cells, or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins." [GOC:kad, PMID:19861655] synonym: "nectar production" RELATED [GOC:kad] is_a: GO:0046903 ! secretion [Term] id: GO:0071837 name: HMG box domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin." [InterPro:IPR009071, PMID:18445004] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0071838 name: cell proliferation in bone marrow namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow." [GOC:mah, PMID:17063141] synonym: "bone marrow cell proliferation" EXACT [GOC:yaf] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0071839 name: apoptosis in bone marrow namespace: biological_process def: "The process of apoptosis in cells in the bone marrow." [GOC:mah, PMID:17063141] synonym: "bone marrow cell apoptosis" EXACT [GOC:yaf] synonym: "bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah] synonym: "killing of bone marrow cells" EXACT [GOC:mah] synonym: "programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah] synonym: "programmed cell death, bone marrow cells" EXACT [GOC:mah] is_a: GO:0006915 ! apoptosis [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0071841 name: cellular component organization or biogenesis at cellular level namespace: biological_process def: "A process that is carried out at the cellular level, and results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0071842 name: cellular component organization at cellular level namespace: biological_process def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] is_a: GO:0016043 ! cellular component organization is_a: GO:0071841 ! cellular component organization or biogenesis at cellular level [Term] id: GO:0071843 name: cellular component biogenesis at cellular level namespace: biological_process def: "A process that is carried out at the cellular level, and that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis is_a: GO:0071841 ! cellular component organization or biogenesis at cellular level [Term] id: GO:0071844 name: cellular component assembly at cellular level namespace: biological_process def: "A process that is carried out at the cellular level and results in the aggregation, arrangement and bonding together of a cellular component." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0071845 name: cellular component disassembly at cellular level namespace: biological_process def: "A process that is carried out at the cellular level and results in the breakdown of a cellular component." [GOC:mah] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0071846 name: actin filament debranching namespace: biological_process def: "An actin filament severing process that results in the removal of actin filament branches specifically at the branch points." [GOC:jh, GOC:mah, PMID:20362448] is_a: GO:0051014 ! actin filament severing [Term] id: GO:0071847 name: TNFSF11-mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of TNFSF11 binding to a cell surface receptor." [GOC:BHF, PMID:18606301] synonym: "RANKL-mediated signaling pathway" EXACT [GOC:BHF] synonym: "TNFSF11-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0071848 name: positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling namespace: biological_process def: "Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade." [GOC:BHF, PMID:18606301] synonym: "positive regulation of ERK1 and ERK2 cascade via RANKL-mediated signaling" EXACT [GOC:BHF] synonym: "positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalling" EXACT [GOC:mah] is_a: GO:0070374 ! positive regulation of ERK1 and ERK2 cascade is_a: GO:0071847 ! TNFSF11-mediated signaling pathway [Term] id: GO:0071849 name: G1 cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw] is_a: GO:0030996 ! cell cycle arrest in response to nitrogen starvation [Term] id: GO:0071850 name: mitotic cell cycle arrest namespace: biological_process def: "The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:mah] synonym: "arrest of mitotic cell cycle progression" EXACT [GOC:mah] synonym: "cessation of mitotic cell cycle" EXACT [GOC:mah] synonym: "termination of mitotic cell cycle" EXACT [GOC:mah] is_a: GO:0007050 ! cell cycle arrest [Term] id: GO:0071851 name: mitotic G1 cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "The process in which the mitotic cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw] synonym: "G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:vw] is_a: GO:0030996 ! cell cycle arrest in response to nitrogen starvation is_a: GO:0071850 ! mitotic cell cycle arrest [Term] id: GO:0071852 name: fungal-type cell wall organization or biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall." [GOC:mah] synonym: "fungal-type cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0070882 ! cellular cell wall organization or biogenesis [Term] id: GO:0071853 name: fungal-type cell wall disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a fungal-type cell wall." [GOC:mah] is_a: GO:0031505 ! fungal-type cell wall organization is_a: GO:0060871 ! cellular cell wall disassembly [Term] id: GO:0071854 name: cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly namespace: biological_process def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the fungal-type cell wall." [GOC:mah] is_a: GO:0070910 ! cell wall macromolecule catabolic process involved in cell wall disassembly relationship: part_of GO:0071853 ! fungal-type cell wall disassembly [Term] id: GO:0071855 name: neuropeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0071857 name: beta-endorphin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-endorphin receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0071858 name: corazonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a corazonin receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0071859 name: neuropeptide F receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuropeptide F receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0071860 name: proctolin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proctolin receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0071861 name: tachykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tachykinin receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0071862 name: protein phosphatase type 1 activator activity namespace: molecular_function def: "Increases the activity of the enzyme protein phosphatase type 1." [GOC:vw] is_a: GO:0008599 ! protein phosphatase type 1 regulator activity is_a: GO:0072542 ! protein phosphatase activator activity [Term] id: GO:0071863 name: regulation of cell proliferation in bone marrow namespace: biological_process def: "A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, PMID:17063141] synonym: "regulation of bone marrow cell proliferation" EXACT [GOC:yaf] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0071838 ! cell proliferation in bone marrow [Term] id: GO:0071864 name: positive regulation of cell proliferation in bone marrow namespace: biological_process def: "A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, PMID:17063141] synonym: "activation of cell proliferation in bone marrow" NARROW [GOC:mah] synonym: "positive regulation of bone marrow cell proliferation" EXACT [GOC:yaf] synonym: "stimulation of cell proliferation in bone marrow" NARROW [GOC:mah] synonym: "up regulation of cell proliferation in bone marrow" EXACT [GOC:mah] synonym: "up-regulation of cell proliferation in bone marrow" EXACT [GOC:mah] synonym: "upregulation of cell proliferation in bone marrow" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0071863 ! regulation of cell proliferation in bone marrow relationship: positively_regulates GO:0071838 ! cell proliferation in bone marrow [Term] id: GO:0071865 name: regulation of apoptosis in bone marrow namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptosis in the bone marrow." [GOC:mah, PMID:17063141] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0071839 ! apoptosis in bone marrow [Term] id: GO:0071866 name: negative regulation of apoptosis in bone marrow namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptosis in the bone marrow." [GOC:mah, PMID:17063141] synonym: "down regulation of apoptosis in bone marrow" EXACT [GOC:mah] synonym: "down-regulation of apoptosis in bone marrow" EXACT [GOC:mah] synonym: "downregulation of apoptosis in bone marrow" EXACT [GOC:mah] synonym: "inhibition of apoptosis in bone marrow" NARROW [GOC:mah] synonym: "negative regulation of bone marrow cell apoptosis" EXACT [GOC:mah, GOC:yaf] synonym: "negative regulation of bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah] synonym: "negative regulation of killing of bone marrow cells" EXACT [GOC:mah] synonym: "negative regulation of programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah] synonym: "negative regulation of programmed cell death, bone marrow cells" EXACT [GOC:mah] is_a: GO:0043066 ! negative regulation of apoptosis is_a: GO:0071865 ! regulation of apoptosis in bone marrow relationship: negatively_regulates GO:0071839 ! apoptosis in bone marrow [Term] id: GO:0071867 name: response to monoamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [CHEBI:35375, GOC:mah] is_a: GO:0014075 ! response to amine stimulus [Term] id: GO:0071868 name: cellular response to monoamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [CHEBI:35375, GOC:mah] is_a: GO:0071418 ! cellular response to amine stimulus is_a: GO:0071867 ! response to monoamine stimulus [Term] id: GO:0071869 name: response to catecholamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [CHEBI:33567, GOC:BHF, GOC:mah] is_a: GO:0071867 ! response to monoamine stimulus [Term] id: GO:0071870 name: cellular response to catecholamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [CHEBI:33567, GOC:BHF, GOC:mah] is_a: GO:0071868 ! cellular response to monoamine stimulus is_a: GO:0071869 ! response to catecholamine stimulus [Term] id: GO:0071871 name: response to epinephrine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [CHEBI:33568, GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "response to adrenaline stimulus" EXACT [GOC:mah] is_a: GO:0071869 ! response to catecholamine stimulus [Term] id: GO:0071872 name: cellular response to epinephrine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [CHEBI:33568, GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "cellular response to adrenaline stimulus" EXACT [GOC:mah] is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:0071871 ! response to epinephrine stimulus [Term] id: GO:0071873 name: response to norepinephrine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [CHEBI:33569, GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "response to noradrenaline stimulus" EXACT [GOC:mah] is_a: GO:0071869 ! response to catecholamine stimulus [Term] id: GO:0071874 name: cellular response to norepinephrine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [CHEBI:33569, GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah] is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:0071873 ! response to norepinephrine stimulus [Term] id: GO:0071875 name: adrenergic receptor signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF] synonym: "adrenergic receptor signalling pathway" EXACT [GOC:mah] synonym: "adrenoceptor signaling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0071876 name: initiation of adrenergic receptor signal transduction namespace: biological_process def: "OBSOLETE. A process of signal initiation in which epinephrine or norepinephrine causes activation of an adrenergic receptor." [GOC:BHF, GOC:mah] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0004935 consider: GO:0005179 consider: GO:0071872 consider: GO:0071874 consider: GO:0071875 [Term] id: GO:0071877 name: regulation of adrenergic receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah] synonym: "regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway relationship: regulates GO:0071875 ! adrenergic receptor signaling pathway [Term] id: GO:0071878 name: negative regulation of adrenergic receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah] synonym: "negative regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0071877 ! regulation of adrenergic receptor signaling pathway relationship: negatively_regulates GO:0071875 ! adrenergic receptor signaling pathway [Term] id: GO:0071879 name: positive regulation of adrenergic receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the adrenergic receptor protein signaling pathway. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah] synonym: "positive regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0071877 ! regulation of adrenergic receptor signaling pathway relationship: positively_regulates GO:0071875 ! adrenergic receptor signaling pathway [Term] id: GO:0071880 name: activation of adenylate cyclase activity by adrenergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:BHF, GOC:mah] synonym: "activation of adenylate cyclase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] synonym: "adrenergic receptor, adenylate cyclase activating pathway" EXACT [GOC:mah] synonym: "adrenergic receptor, adenylyl cyclase activating pathway" EXACT [GOC:mah] is_a: GO:0007189 ! activation of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0071875 ! adrenergic receptor signaling pathway [Term] id: GO:0071881 name: inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:BHF, GOC:mah] synonym: "adrenergic receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:mah] synonym: "adrenergic receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:mah] synonym: "inhibition of adenylate cyclase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0071875 ! adrenergic receptor signaling pathway [Term] id: GO:0071882 name: activation of phospholipase C activity by adrenergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:BHF, GOC:mah] synonym: "activation of phospholipase C activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] synonym: "adrenergic receptor, phospholipase C activating pathway" EXACT [GOC:mah] synonym: "phospholipase C-activating adrenergic receptor signaling pathway" EXACT [GOC:mah] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0071875 ! adrenergic receptor signaling pathway [Term] id: GO:0071883 name: activation of MAPK activity by adrenergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, followed by the activation of a MAP kinase." [GOC:BHF, GOC:mah] synonym: "activation of MAP kinase activity by adrenergic receptor signaling pathway" EXACT [GOC:mah] synonym: "activation of MAP kinase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] synonym: "activation of MAPK activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0071875 ! adrenergic receptor signaling pathway [Term] id: GO:0071884 name: vitamin D receptor activator activity namespace: molecular_function def: "Interacting (directly or indirectly) with vitamin D receptors such that the proportion of receptors in the active form is increased." [GOC:BHF, GOC:vk] is_a: GO:0030546 ! receptor activator activity is_a: GO:0030548 ! acetylcholine receptor regulator activity [Term] id: GO:0071885 name: N-terminal protein N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser." [PMID:20481588] synonym: "X-Pro-Lys N-terminal methyltransferase" NARROW [GOC:rn] is_a: GO:0008276 ! protein methyltransferase activity [Term] id: GO:0071886 name: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding namespace: molecular_function def: "Interacting selectively and non-covalently with the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug." [CHEBI:100436, GOC:yaf, PMID:19057895] synonym: "(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding" EXACT [CHEBI:100436] synonym: "1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding" EXACT [PMID:19057895] synonym: "4-iodo-2,5-dimethoxyphenylisopropylamine binding" EXACT [PubChem_Compound:1229] is_a: GO:0043176 ! amine binding [Term] id: GO:0071887 name: leukocyte apoptosis namespace: biological_process def: "The process of apoptosis in a leukocyte." [CL:0000738, GOC:BHF, GOC:mah] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). is_a: GO:0006915 ! apoptosis [Term] id: GO:0071888 name: macrophage apoptosis namespace: biological_process def: "The process of apoptosis in a macrophage." [CL:0000235, GOC:BHF, GOC:mah] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). is_a: GO:0071887 ! leukocyte apoptosis [Term] id: GO:0071889 name: 14-3-3 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, InterPro:IPR000308, PMID:15167810, PMID:19575580, PRO:000003237] is_a: GO:0005515 ! protein binding [Term] id: GO:0071890 name: bicarbonate binding namespace: molecular_function def: "Interacting selectively and non-covalently with bicarbonate (CHO3-) ions." [CHEBI:17544] synonym: "hydrogencarbonate binding" EXACT [CHEBI:17544] is_a: GO:0043168 ! anion binding [Term] id: GO:0071891 name: N-terminal peptidyl-proline dimethylation involved in translation namespace: biological_process def: "An N-terminal peptidyl-proline dimethylation process that contributes to translation." [GOC:mah] is_a: GO:0018016 ! N-terminal peptidyl-proline dimethylation relationship: part_of GO:0006412 ! translation [Term] id: GO:0071892 name: thrombocyte activation namespace: biological_process def: "A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals." [GOC:lb, GOC:mah, PMID:10606877, PMID:15634265, PMID:20180901] synonym: "blood coagulation, thrombocyte activation" EXACT [GOC:mah] is_a: GO:0001775 ! cell activation relationship: part_of GO:0007596 ! blood coagulation [Term] id: GO:0071893 name: BMP signaling pathway involved in nephric duct formation namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to nephric duct formation." [GOC:mah, GOC:mtg_kidney_jan10] synonym: "BMP signalling pathway involved in nephric duct formation" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0072179 ! nephric duct formation [Term] id: GO:0071894 name: histone H2B conserved C-terminal lysine ubiquitination namespace: biological_process def: "A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:mah, GOC:vw] synonym: "budding yeast H2B K123 ubiquitination" NARROW [GOC:vw] synonym: "fission yeast H2B K119 ubiquitination" NARROW [GOC:vw] synonym: "mammalian H2B K120 ubiquitination" NARROW [GOC:vw] is_a: GO:0033523 ! histone H2B ubiquitination [Term] id: GO:0071895 name: odontoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentine." [GOC:sl, PMID:20425127] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0071896 name: protein localization to adherens junction namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:BHF, GOC:mah] synonym: "protein localisation to adherens junction" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization [Term] id: GO:0071897 name: DNA biosynthetic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:mah] subset: gosubset_prok synonym: "DNA anabolism" EXACT [GOC:mah] synonym: "DNA biosynthesis" EXACT [GOC:mah] synonym: "DNA formation" EXACT [GOC:mah] synonym: "DNA synthesis" EXACT [GOC:mah] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:0071898 name: regulation of estrogen receptor binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of estrogen receptor binding, interacting selectively with a an estrogen receptor." [GOC:BHF, GOC:mah] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0071899 name: negative regulation of estrogen receptor binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor." [GOC:BHF, GOC:mah] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:0071898 ! regulation of estrogen receptor binding [Term] id: GO:0071900 name: regulation of protein serine/threonine kinase activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] is_a: GO:0045859 ! regulation of protein kinase activity [Term] id: GO:0071901 name: negative regulation of protein serine/threonine kinase activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:BHF, GOC:mah] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity [Term] id: GO:0071902 name: positive regulation of protein serine/threonine kinase activity namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity [Term] id: GO:0071903 name: protein N-linked N-acetylglucosaminylation via asparagine namespace: biological_process def: "A process of protein N-linked glycosylation via asparagine in which N-acetylglucosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)amino-4-oxobutanoic acid residue." [RESID:AA0151] synonym: "protein amino acid N-linked N-acetylglucosaminylation via asparagine" EXACT [GOC:bf] xref: RESID:AA0151 is_a: GO:0018279 ! protein N-linked glycosylation via asparagine [Term] id: GO:0071904 name: protein N-linked N-acetylgalactosaminylation via asparagine namespace: biological_process def: "A process of protein N-linked glycosylation via asparagine in which N-acetylgalactosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid residue." [RESID:AA0420] synonym: "protein amino acid N-linked N-acetylgalactosaminylation via asparagine" EXACT [GOC:bf] xref: RESID:AA0420 is_a: GO:0018279 ! protein N-linked glycosylation via asparagine [Term] id: GO:0071905 name: protein N-linked glucosylation via asparagine namespace: biological_process def: "A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue." [RESID:AA0421] synonym: "protein amino acid N-linked glucosylation via asparagine" EXACT [GOC:bf] xref: RESID:AA0421 is_a: GO:0018279 ! protein N-linked glycosylation via asparagine [Term] id: GO:0071906 name: CRD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins." [GOC:yaf, PMID:19460168] synonym: "context dependent regulatory domain binding" EXACT [GOC:mah] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0071907 name: determination of digestive tract left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs] synonym: "determination of gut left/right asymmetry" EXACT [GOC:cvs] synonym: "determination of left/right asymmetry of the digestive tract" EXACT [GOC:cvs] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0071908 name: determination of intestine left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism." [GOC:cvs] is_a: GO:0071907 ! determination of digestive tract left/right asymmetry [Term] id: GO:0071909 name: determination of stomach left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the stomach with respect to the left and right halves of the organism." [GOC:cvs] is_a: GO:0071907 ! determination of digestive tract left/right asymmetry [Term] id: GO:0071910 name: determination of liver left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the liver with respect to the left and right halves of the organism." [GOC:cvs] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0001889 ! liver development [Term] id: GO:0071911 name: synchronous neurotransmitter secretion namespace: biological_process def: "Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933] is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0071912 name: asynchronous neurotransmitter secretion namespace: biological_process def: "Release of neurotransmitter at the synapse that persists for tens to hundreds of milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933] is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0071913 name: citrate secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mah, GOC:mtg_transport, GOC:vw] subset: gosubset_prok synonym: "citrate carrier activity" EXACT [GOC:mah] is_a: GO:0005371 ! tricarboxylate secondary active transmembrane transporter activity is_a: GO:0015137 ! citrate transmembrane transporter activity [Term] id: GO:0071914 name: prominosome namespace: cellular_component def: "An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known." [PMID:15976444, PMID:17109118, PMID:17283184] synonym: "prominin-containing extracellular membrane vesicle" EXACT [GOC:curators] is_a: GO:0031988 ! membrane-bounded vesicle is_a: GO:0065010 ! extracellular membrane-bounded organelle [Term] id: GO:0071915 name: protein-lysine lysylation namespace: biological_process def: "The addition of lysine group to a lysine residue in a protein, producing N6-(lysyl)-L-lysine. This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:imk, GOC:jsg, PMID:20729861] synonym: "protein amino acid lysylation" EXACT [GOC:imk] is_a: GO:0018205 ! peptidyl-lysine modification relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification [Term] id: GO:0071916 name: dipeptide transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of a dipeptide across a membrane into, out of or within a cell, or between cells. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:mah] is_a: GO:0035673 ! oligopeptide transmembrane transporter activity is_a: GO:0042936 ! dipeptide transporter activity [Term] id: GO:0071917 name: triose-phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a triose phosphate from one side of a membrane to the other." [GOC:mah, GOC:vw] is_a: GO:0015145 ! monosaccharide transmembrane transporter activity [Term] id: GO:0071918 name: urea transmembrane transport namespace: biological_process def: "The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015840 ! urea transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0071919 name: G-quadruplex DNA formation namespace: biological_process def: "A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature." [GOC:sre, PMID:20098422] synonym: "G quadruplex DNA formation" EXACT [GOC:mah] synonym: "G quartet DNA formation" EXACT [GOC:mah] synonym: "G-quartet DNA formation" EXACT [GOC:mah] is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0071920 name: cleavage body namespace: cellular_component def: "A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing." [PMID:10564273, PMID:11598190, PMID:8654386] is_a: GO:0016604 ! nuclear body [Term] id: GO:0071921 name: cohesin localization to chromatin namespace: biological_process def: "A process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah, PMID:10882066, PMID:17113138] synonym: "cohesin association with chromatin" EXACT [GOC:lb] synonym: "cohesin localisation to chromatin" EXACT [GOC:mah] is_a: GO:0071168 ! protein localization to chromatin relationship: part_of GO:0007062 ! sister chromatid cohesion [Term] id: GO:0071922 name: regulation of cohesin localization to chromatin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138] synonym: "regulation of cohesin association with chromatin" EXACT [GOC:lb] synonym: "regulation of cohesin localisation to chromatin" EXACT [GOC:mah] is_a: GO:0007063 ! regulation of sister chromatid cohesion is_a: GO:0032880 ! regulation of protein localization is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0071921 ! cohesin localization to chromatin [Term] id: GO:0071923 name: negative regulation of cohesin localization to chromatin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138] synonym: "negative regulation of cohesin association with chromatin" EXACT [GOC:lb] synonym: "negative regulation of cohesin localisation to chromatin" EXACT [GOC:mah] is_a: GO:0045875 ! negative regulation of sister chromatid cohesion is_a: GO:0071922 ! regulation of cohesin localization to chromatin relationship: negatively_regulates GO:0071921 ! cohesin localization to chromatin [Term] id: GO:0071924 name: chemokine (C-C motif) ligand 22 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:18832724] synonym: "C-C motif chemokine 22 production" EXACT [GOC:mah] synonym: "CCL-22 production" EXACT [GOC:mah] synonym: "CCL22 production" EXACT [GOC:mah] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071925 name: thymic stromal lymphopoietin production namespace: biological_process def: "The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:17129180] synonym: "TSLP production" EXACT [GOC:mah] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071926 name: endocannabinoid signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol." [GOC:mah, PMID:15550444] synonym: "endocannabinoid signalling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0071927 name: octopamine signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor." [GOC:mah, PMID:15355245] synonym: "octopamine signalling pathway" EXACT [GOC:mah] is_a: GO:0007211 ! octopamine or tyramine signaling pathway [Term] id: GO:0071928 name: tyramine signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor." [GOC:mah, PMID:15355245] synonym: "tyramine signalling pathway" EXACT [GOC:mah] is_a: GO:0007211 ! octopamine or tyramine signaling pathway [Term] id: GO:0071929 name: alpha-tubulin acetylation namespace: biological_process def: "The addition of an acetyl group to the lysine 40 residue of alpha-tubulin." [GOC:kmv, PMID:17786050] is_a: GO:0018393 ! internal peptidyl-lysine acetylation [Term] id: GO:0071930 name: negative regulation of transcription involved in G1/S phase of mitotic cell cycle namespace: biological_process def: "Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw] synonym: "negative regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah] is_a: GO:0000083 ! regulation of transcription involved in G1/S phase of mitotic cell cycle is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter [Term] id: GO:0071931 name: positive regulation of transcription involved in G1/S phase of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw] synonym: "positive regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah] is_a: GO:0000083 ! regulation of transcription involved in G1/S phase of mitotic cell cycle is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter [Term] id: GO:0071932 name: replication fork reversal namespace: biological_process def: "Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved." [PMID:19406929] is_a: GO:0031297 ! replication fork processing [Term] id: GO:0071933 name: Arp2/3 complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)." [GOC:mah] is_a: GO:0032403 ! protein complex binding [Term] id: GO:0071934 name: thiamine transmembrane transport namespace: biological_process def: "The directed movement of thiamine across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mah] synonym: "thiamin transmembrane transport" EXACT [GOC:mah] synonym: "vitamin B1 transmembrane transport" EXACT [GOC:mah] is_a: GO:0015888 ! thiamine transport is_a: GO:0035461 ! vitamin transmembrane transport [Term] id: GO:0071935 name: octopamine signaling pathway involved in response to food namespace: biological_process def: "The series of molecular signals initiated by binding of octopamine to a receptor on the surface of the target cell that contributes to a response to a food stimulus." [GOC:mah, PMID:19609300] synonym: "octopamine signalling pathway involved in response to food" EXACT [GOC:mah] is_a: GO:0071927 ! octopamine signaling pathway relationship: part_of GO:0032094 ! response to food [Term] id: GO:0071936 name: coreceptor activity involved in Wnt receptor signaling pathway namespace: molecular_function def: "Combining with an extracellular messenger, and in cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt receptor signaling pathway." [GOC:BHF, GOC:mah] synonym: "coreceptor activity involved in Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0015026 ! coreceptor activity [Term] id: GO:0071937 name: barrier septum formation involved in cell cycle cytokinesis namespace: biological_process def: "A barrier septum formation process that occurs during, and contributes to, cytokinesis that occurs in the context of cell cycle progression." [GOC:mah] is_a: GO:0000917 ! barrier septum formation relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0071938 name: vitamin A transport namespace: biological_process def: "The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551] synonym: "vitamin A uptake and transport" RELATED [GOC:rs] is_a: GO:0046865 ! terpenoid transport is_a: GO:0051180 ! vitamin transport [Term] id: GO:0071939 name: vitamin A import namespace: biological_process def: "The directed movement of vitamin A into a cell or organelle. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551] synonym: "vitamin A uptake" EXACT [GOC:mah, GOC:rs] is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0071938 ! vitamin A transport [Term] id: GO:0071940 name: fungal-type cell wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall." [GOC:mah] synonym: "fungal-type cell wall formation" RELATED [GOC:mah] is_a: GO:0070726 ! cell wall assembly relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis [Term] id: GO:0071941 name: nitrogen cycle metabolic process namespace: biological_process def: "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization." [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle] subset: goslim_generic subset: goslim_pombe xref: Wikipedia:Nitrogen_cycle is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0071942 name: XPC complex namespace: cellular_component def: "A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2." [PMID:11279143, PMID:15964821, PMID:19941824] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0071943 name: Myc-Max complex namespace: cellular_component def: "A transcriptional factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max." [GOC:cna, PMID:16620027, PMID:16620031, PMID:20170194] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0071944 name: cell periphery namespace: cellular_component def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures." [GOC:mah] is_a: GO:0044464 ! cell part [Term] id: GO:0071945 name: regulation of flagellar cell motility by regulation of motor speed namespace: biological_process def: "A process that modulates flagellar motility by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein. This process is observed in prokaryotes, where it requires cyclic di-GMP binding to the brake protein." [GOC:mah, PMID:20371342] is_a: GO:2000153 ! regulation of flagellar cell motility [Term] id: GO:0071946 name: cis-acting DNA replication termination namespace: biological_process def: "A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing." [GOC:vw, PMID:20850009] synonym: "cis acting DNA replication termination" EXACT [GOC:vw] is_a: GO:0071170 ! site-specific DNA replication termination [Term] id: GO:0071947 name: protein deubiquitination involved in ubiquitin-dependent protein catabolic process namespace: biological_process def: "The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism." [GOC:mah] is_a: GO:0016579 ! protein deubiquitination relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process [Term] id: GO:0071948 name: activation-induced B cell apoptosis namespace: biological_process def: "B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death." [GOC:tfm, PMID:11032170, PMID:19300454] synonym: "activated B cell apoptosis" BROAD [GOC:tfm] synonym: "activation-induced B-cell apoptosis" EXACT [GOC:tfm] synonym: "activation-induced cell death of B cells" EXACT [GOC:tfm] synonym: "activation-induced cell death of B lymphocytes" EXACT [GOC:tfm] synonym: "activation-induced cell death of B-cells" EXACT [GOC:tfm] synonym: "activation-induced cell death of B-lymphocytes" EXACT [GOC:tfm] synonym: "AICD" BROAD [GOC:tfm] synonym: "antigen-driven apoptosis" BROAD [GOC:tfm] is_a: GO:0001783 ! B cell apoptosis [Term] id: GO:0071949 name: FAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] subset: gosubset_prok synonym: "oxidized flavin adenine dinucleotide binding" EXACT [GOC:mah] synonym: "oxidized flavine-adenine dinucleotide binding" EXACT [GOC:mah] is_a: GO:0050660 ! flavin adenine dinucleotide binding [Term] id: GO:0071950 name: FADH2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] subset: gosubset_prok synonym: "reduced flavin adenine dinucleotide binding" EXACT [GOC:mah] synonym: "reduced flavine-adenine dinucleotide binding" EXACT [GOC:mah] is_a: GO:0050660 ! flavin adenine dinucleotide binding [Term] id: GO:0071951 name: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet)." [GOC:jsg, PMID:5337045] is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0071952 name: conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of O-phosphoserine charged on a tRNA(Cys) to cysteinyl-tRNA." [GOC:jsg, PMID:17351629, PMID:18559341] comment: Note that this process has been observed in some archeal and bacterial species. subset: gosubset_prok is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0071953 name: elastic fiber namespace: cellular_component def: "An extracellular matrix part that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620] synonym: "elastic fibre" EXACT [GOC:mah] synonym: "elastin fiber" EXACT [GOC:BHF] is_a: GO:0044420 ! extracellular matrix part [Term] id: GO:0071954 name: chemokine (C-C motif) ligand 11 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, MGI:103576, PMID:9600955] synonym: "C-C motif chemokine 11 production" EXACT [GOC:mah] synonym: "CCL-11 production" EXACT [GOC:mah] synonym: "CCL11 production" EXACT [GOC:mah] synonym: "eotaxin production" BROAD [GOC:mah] synonym: "eotaxin-1 production" EXACT [GOC:mah] is_a: GO:0032602 ! chemokine production [Term] id: GO:0071955 name: recycling endosome to Golgi transport namespace: biological_process def: "The directed movement of substances from recycling endosomes to the Golgi." [GOC:lb] is_a: GO:0042147 ! retrograde transport, endosome to Golgi is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0071956 name: cellular component maintenance at cellular level namespace: biological_process def: "A process that is carried out at the cellular level and results in the preservation of a cellular component in a stable functional or structural state." [GOC:mah] is_a: GO:0043954 ! cellular component maintenance is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0071957 name: old spindle pole body namespace: cellular_component def: "The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis." [GOC:mah, GOC:vw, PMID:15132994] synonym: "old SPB" EXACT [GOC:mah] is_a: GO:0005816 ! spindle pole body [Term] id: GO:0071958 name: new spindle pole body namespace: cellular_component def: "The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize." [GOC:mah, GOC:vw, PMID:15132994] synonym: "new SPB" EXACT [GOC:mah] is_a: GO:0005816 ! spindle pole body [Term] id: GO:0071959 name: maintenance of mitotic sister chromatid cohesion, arms namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436] synonym: "maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:mah] synonym: "maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:mah] is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion relationship: part_of GO:0071961 ! mitotic sister chromatid cohesion, arms [Term] id: GO:0071960 name: maintenance of mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436] synonym: "maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah] synonym: "maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:mah] synonym: "maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:mah] is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion relationship: part_of GO:0071962 ! mitotic sister chromatid cohesion, centromeric [Term] id: GO:0071961 name: mitotic sister chromatid cohesion, arms namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during mitosis." [GOC:mah] synonym: "mitotic sister chromatid cohesion along arms" EXACT [GOC:mah] synonym: "sister chromatid cohesion along arms at mitosis" EXACT [GOC:mah] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion [Term] id: GO:0071962 name: mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "The cell cycle process in which centromeres of sister chromatids are joined during mitosis." [GOC:mah] synonym: "centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah] synonym: "mitotic sister chromatid cohesion at centromere" EXACT [GOC:mah] synonym: "sister chromatid cohesion at centromere at mitosis" EXACT [GOC:mah] is_a: GO:0070601 ! centromeric sister chromatid cohesion relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion [Term] id: GO:0071965 name: multicellular organismal locomotion namespace: biological_process def: "Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another." [GOC:mah] is_a: GO:0050879 ! multicellular organismal movement [Term] id: GO:0071966 name: fungal-type cell wall polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the polysaccharides which make up the fungal-type cell wall." [GOC:mah] is_a: GO:0010383 ! cell wall polysaccharide metabolic process relationship: part_of GO:0071852 ! fungal-type cell wall organization or biogenesis [Term] id: GO:0071967 name: lipopolysaccharide core heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+." [MetaCyc:RXN0-5122] subset: gosubset_prok synonym: "LPS core heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY] xref: MetaCyc:RXN0-5122 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity [Term] id: GO:0071968 name: lipid A-core heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+." [MetaCyc:RXN0-5127] subset: gosubset_prok xref: MetaCyc:RXN0-5127 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity [Term] id: GO:0071969 name: fungal-type cell wall 1,3-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-glucan metabolic process" BROAD [] synonym: "fungal-type cell wall 1,3-beta-glucan metabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0034407 ! cell wall 1,3-beta-D-glucan metabolic process is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process [Term] id: GO:0071970 name: fungal-type cell wall 1,3-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-glucan biosynthetic process" BROAD [] synonym: "fungal-type cell wall 1,3-beta-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-glucan synthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0034411 ! cell wall 1,3-beta-D-glucan biosynthetic process is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process is_a: GO:0071969 ! fungal-type cell wall 1,3-beta-D-glucan metabolic process [Term] id: GO:0071971 name: extracellular vesicular exosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:mah, GOC:tfm, PMID:19442504] is_a: GO:0070925 ! organelle assembly [Term] id: GO:0071972 name: peptidoglycan L,D-transpeptidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine." [MetaCyc:RXN-11349] xref: MetaCyc:RXN-11349 is_a: GO:0004185 ! serine-type carboxypeptidase activity [Term] id: GO:0071973 name: bacterial-type flagellar cell motility namespace: biological_process def: "Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:mah] subset: gosubset_prok synonym: "flagellin-based flagellar cell motility" EXACT [GOC:mah] is_a: GO:0060286 ! flagellar cell motility [Term] id: GO:0071974 name: microtubule-based flagellar cell motility namespace: biological_process def: "Cell motility due to the motion of one or more microtubule-based flagella. A microtubule-based flagellum is a long, whiplike protrusion from the surface of a eukaryotic cell that is similar in structure to a cilium." [GOC:mah] is_a: GO:0060286 ! flagellar cell motility [Term] id: GO:0071975 name: cell swimming namespace: biological_process def: "Cell motility that results in the smooth movement of a cell through a liquid medium." [PMID:18461074] subset: gosubset_prok synonym: "cell swimming motility" EXACT [GOC:mah] is_a: GO:0048870 ! cell motility [Term] id: GO:0071976 name: cell gliding namespace: biological_process def: "Cell motility that results in the smooth movement of a cell along a solid surface." [PMID:18461074] subset: gosubset_prok synonym: "cell gliding motility" EXACT [GOC:mah] is_a: GO:0048870 ! cell motility [Term] id: GO:0071977 name: bacterial-type flagellar swimming motility namespace: biological_process def: "Bacterial-type flagellar motility that results in the smooth movement of a cell through a liquid medium." [PMID:18461074] subset: gosubset_prok synonym: "bacterial-type flagellum-mediated cell swimming" EXACT [GOC:mah] is_a: GO:0071973 ! bacterial-type flagellar cell motility is_a: GO:0071975 ! cell swimming [Term] id: GO:0071978 name: bacterial-type flagellar swarming motility namespace: biological_process def: "Bacterial-type flagellar motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria." [PMID:14527279, PMID:18461074] subset: gosubset_prok synonym: "bacterial-type flagellum-mediated cell swarming" EXACT [GOC:mah] is_a: GO:0071973 ! bacterial-type flagellar cell motility [Term] id: GO:0071979 name: cytoskeleton-mediated cell swimming namespace: biological_process def: "Cell motility in which contractile cytoskeletal elements alter cell shape, resulting in the smooth movement of a cell through a liquid medium." [PMID:18461074] subset: gosubset_prok synonym: "cytoskeleton-mediated swimming motility" EXACT [GOC:mah] is_a: GO:0071975 ! cell swimming [Term] id: GO:0071980 name: cell surface adhesin-mediated gliding motility namespace: biological_process def: "Cell gliding that results from the actions of cell surface adhesin proteins that are propelled by membrane motor proteins." [PMID:18461074] subset: gosubset_prok is_a: GO:0071976 ! cell gliding [Term] id: GO:0071981 name: exit from diapause namespace: biological_process def: "The dormancy process that results in exit from diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah] is_a: GO:0022611 ! dormancy process [Term] id: GO:0071982 name: maintenance of diapause namespace: biological_process def: "The dormancy process that results an organism remaining in diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah] is_a: GO:0022611 ! dormancy process [Term] id: GO:0071983 name: exit from reproductive diapause namespace: biological_process def: "The dormancy process that results in exit from reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah] is_a: GO:0071981 ! exit from diapause [Term] id: GO:0071984 name: maintenance of reproductive diapause namespace: biological_process def: "The dormancy process that results an organism remaining in reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah] is_a: GO:0071982 ! maintenance of diapause [Term] id: GO:0071985 name: multivesicular body sorting pathway namespace: biological_process def: "A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537] is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0071986 name: Ragulator complex namespace: cellular_component def: "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), and C11orf59 (p18). The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, and is also involved in ERK/MAPK signaling." [PMID:19177150, PMID:20381137] synonym: "MAPKSP1/ROBLD3/C11orf59 complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0031902 ! late endosome membrane relationship: part_of GO:0045121 ! membrane raft [Term] id: GO:0071987 name: WD40-repeat domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain." [GOC:yaf, InterPro:IPR017986] synonym: "beta-transducin repeat domain binding" EXACT [GOC:yaf] synonym: "WD domain binding" EXACT [GOC:yaf] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0071988 name: protein localization to spindle pole body namespace: biological_process def: "A process in which a protein is transported to, or maintained at, the spindle pole body." [GOC:mah] synonym: "protein localisation to spindle pole body" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0071989 name: establishment of protein localization to spindle pole body namespace: biological_process def: "The directed movement of a protein to a specific location at the spindle pole body." [GOC:mah] synonym: "establishment of protein localisation to spindle pole body" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0071988 ! protein localization to spindle pole body [Term] id: GO:0071990 name: maintenance of protein location at spindle pole body namespace: biological_process def: "Any process in which a protein is maintained in a specific location at the spindle pole body, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization to organelle relationship: part_of GO:0071988 ! protein localization to spindle pole body [Term] id: GO:0071991 name: phytochelatin transporter activity namespace: molecular_function def: "Enables the directed movement of a phytochelatin into, out of or within a cell, or between cells. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015197 ! peptide transporter activity [Term] id: GO:0071992 name: phytochelatin transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of a phytochelatin across a membrane into, out of or within a cell, or between cells. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0022857 ! transmembrane transporter activity is_a: GO:0071991 ! phytochelatin transporter activity [Term] id: GO:0071993 name: phytochelatin transport namespace: biological_process def: "The directed movement of a phytochelatin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] is_a: GO:0015833 ! peptide transport [Term] id: GO:0071994 name: phytochelatin transmembrane transport namespace: biological_process def: "The directed movement of a phytochelatin across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071993 ! phytochelatin transport [Term] id: GO:0071995 name: phytochelatin import into vacuole namespace: biological_process def: "The directed movement of phytochelatins into the vacuole. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] synonym: "phytochelatin transport into vacuole" EXACT [GOC:vw] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0071994 ! phytochelatin transmembrane transport [Term] id: GO:0071996 name: glutathione import into vacuole namespace: biological_process def: "The directed movement of glutathione into the vacuole." [GOC:mah] synonym: "glutathione transport into vacuole" EXACT [GOC:vw] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0034775 ! glutathione transmembrane transport [Term] id: GO:0071997 name: glutathione S-conjugate-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of glutathione S-conjugate across a membrane." [GOC:mah] is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0071998 name: ascospore release from ascus namespace: biological_process def: "A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mah] synonym: "ascospore liberation" EXACT [DOI:10.1016/S0953-7562(96)80057-8] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0071999 name: extracellular polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures." [GOC:mah, GOC:vw] subset: gosubset_prok synonym: "extracellular polysaccharide breakdown" EXACT [GOC:mah] synonym: "extracellular polysaccharide catabolism" EXACT [GOC:mah] synonym: "extracellular polysaccharide degradation" EXACT [GOC:mah] is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0046379 ! extracellular polysaccharide metabolic process [Term] id: GO:0072000 name: extracellular polysaccharide catabolic process involved in ascospore release from ascus namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah, GOC:vw] subset: gosubset_prok synonym: "ascus catabolic process" RELATED [GOC:vw] synonym: "ascus endolysis" RELATED [GOC:vw] synonym: "extracellular polysaccharide breakdown involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "extracellular polysaccharide catabolism involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "extracellular polysaccharide degradation involved in ascospore release from ascus" EXACT [GOC:mah] is_a: GO:0071999 ! extracellular polysaccharide catabolic process relationship: part_of GO:0071998 ! ascospore release from ascus [Term] id: GO:0072001 name: renal system development namespace: biological_process def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System] synonym: "urinary system development" BROAD [GOC:yaf] synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463] is_a: GO:0048731 ! system development relationship: part_of GO:0001655 ! urogenital system development [Term] id: GO:0072002 name: Malpighian tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0048513 ! organ development is_a: GO:0061326 ! renal tubule development [Term] id: GO:0072003 name: kidney rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] synonym: "kidney anlage formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060993 ! kidney morphogenesis [Term] id: GO:0072004 name: kidney field specification namespace: biological_process def: "The process that results in the delineation of regions of the embryo into the area in which the kidney rudiment will develop." [GOC:mtg_kidney_jan10] synonym: "specification of kidney anlage" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0010092 ! specification of organ identity relationship: part_of GO:0072003 ! kidney rudiment formation [Term] id: GO:0072005 name: maintenance of kidney identity namespace: biological_process def: "The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] synonym: "maintenance of kidney anlage identity" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0048496 ! maintenance of organ identity relationship: part_of GO:0072003 ! kidney rudiment formation [Term] id: GO:0072006 name: nephron development namespace: biological_process def: "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072007 name: mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development [Term] id: GO:0072008 name: glomerular mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072007 ! mesangial cell differentiation relationship: part_of GO:0072109 ! glomerular mesangium development [Term] id: GO:0072009 name: nephron epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0072006 ! nephron development [Term] id: GO:0072010 name: glomerular epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0032835 ! glomerulus development [Term] id: GO:0072011 name: glomerular endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0072012 ! glomerulus vasculature development [Term] id: GO:0072012 name: glomerulus vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10] synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0001568 ! blood vessel development relationship: part_of GO:0032835 ! glomerulus development [Term] id: GO:0072013 name: glomus development namespace: biological_process def: "The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." [GOC:mtg_kidney_jan10, PMID:10572058, PMID:15647339, PMID:9268568, XAO:0000318] synonym: "pronephric glomus development" EXACT [GOC:mtg_kidney_jan10, PMID:15895368] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0072014 name: proximal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development [Term] id: GO:0072015 name: glomerular visceral epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] synonym: "podocyte development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation [Term] id: GO:0072016 name: glomerular parietal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] synonym: "Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation [Term] id: GO:0072017 name: distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development [Term] id: GO:0072019 name: proximal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072014 ! proximal tubule development [Term] id: GO:0072020 name: proximal straight tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule." [GOC:mtg_kidney_jan10] synonym: "S3 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072014 ! proximal tubule development [Term] id: GO:0072021 name: ascending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072070 ! loop of Henle development [Term] id: GO:0072022 name: descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072070 ! loop of Henle development [Term] id: GO:0072023 name: thick ascending limb development namespace: biological_process alt_id: GO:0072026 def: "The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10] synonym: "TAL development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072017 ! distal tubule development [Term] id: GO:0072024 name: macula densa development namespace: biological_process def: "The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072006 ! nephron development relationship: part_of GO:0072051 ! juxtaglomerular apparatus development [Term] id: GO:0072025 name: distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is a portion of the nephron tubule that connects the loop of Henle to the collecting duct." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072017 ! distal tubule development [Term] id: GO:0072027 name: connecting tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct." [GOC:mtg_kidney_jan10] synonym: "connecting duct development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development [Term] id: GO:0072028 name: nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060993 ! kidney morphogenesis relationship: part_of GO:0072006 ! nephron development [Term] id: GO:0072029 name: long nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla." [GOC:mtg_kidney_jan10] synonym: "juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development [Term] id: GO:0072030 name: short nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development [Term] id: GO:0072031 name: proximal convoluted tubule segment 1 development namespace: biological_process def: "The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:mtg_kidney_jan10, MA:0002612] synonym: "S1 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072019 ! proximal convoluted tubule development [Term] id: GO:0072032 name: proximal convoluted tubule segment 2 development namespace: biological_process def: "The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride." [GOC:mtg_kidney_jan10, MA:0002613] synonym: "S2 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072019 ! proximal convoluted tubule development [Term] id: GO:0072033 name: renal vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0072077 ! renal vesicle morphogenesis [Term] id: GO:0072034 name: renal vesicle induction namespace: biological_process def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle." [GOC:mtg_kidney_jan10] synonym: "nephron induction" EXACT [GOC:mtg_kidney_jan10] synonym: "positive regulation of nephron formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0031128 ! developmental induction is_a: GO:0090184 ! positive regulation of kidney development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: positively_regulates GO:0072033 ! renal vesicle formation [Term] id: GO:0072035 name: pre-tubular aggregate formation namespace: biological_process def: "The cell adhesion process in which mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10] synonym: "mesenchymal cell condensation involved in renal vesicle formation" EXACT [GOC:mtg_kidney_jan10] synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0072033 ! renal vesicle formation [Term] id: GO:0072036 name: mesenchymal to epithelial transition involved in renal vesicle formation namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0060231 ! mesenchymal to epithelial transition relationship: part_of GO:0072033 ! renal vesicle formation [Term] id: GO:0072037 name: mesenchymal stem cell differentiation involved in nephron morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development is_a: GO:0072497 ! mesenchymal stem cell differentiation relationship: part_of GO:0072028 ! nephron morphogenesis [Term] id: GO:0072038 name: mesenchymal stem cell maintenance involved in nephron morphogenesis namespace: biological_process def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0035019 ! somatic stem cell maintenance relationship: part_of GO:0072028 ! nephron morphogenesis [Term] id: GO:0072039 name: regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis namespace: biological_process def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0042981 ! regulation of apoptosis is_a: GO:0090183 ! regulation of kidney development is_a: GO:2000027 ! regulation of organ morphogenesis is_a: GO:2000036 ! regulation of stem cell maintenance relationship: regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis [Term] id: GO:0072040 name: negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis namespace: biological_process def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0043066 ! negative regulation of apoptosis is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0072039 ! regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis relationship: negatively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis [Term] id: GO:0072041 name: positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis namespace: biological_process def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0072039 ! regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis relationship: positively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis [Term] id: GO:0072042 name: regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation and contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072091 ! regulation of stem cell proliferation relationship: regulates GO:0072090 ! mesenchymal stem cell proliferation involved in nephron morphogenesis [Term] id: GO:0072043 name: regulation of pre-tubular aggregate formation by cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process in which mammary mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10] synonym: "regulation of pre-tubular aggregate formation by cell-cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0090183 ! regulation of kidney development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0072035 ! pre-tubular aggregate formation [Term] id: GO:0072044 name: collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072045 name: convergent extension involved in nephron morphogenesis namespace: biological_process def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0060029 ! convergent extension involved in organogenesis relationship: part_of GO:0072028 ! nephron morphogenesis [Term] id: GO:0072046 name: establishment of planar polarity involved in nephron morphogenesis namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] synonym: "establishment of planar cell polarity involved in nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10] is_a: GO:0001736 ! establishment of planar polarity relationship: part_of GO:0072028 ! nephron morphogenesis [Term] id: GO:0072047 name: proximal/distal pattern formation involved in nephron development namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10] synonym: "proximal-distal pattern formation involved in nephron development" EXACT [GOC:mtg_kidney_jan10] synonym: "proximal/distal nephron patterning" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0009954 ! proximal/distal pattern formation is_a: GO:0061004 ! pattern specification involved in kidney development relationship: part_of GO:0072006 ! nephron development [Term] id: GO:0072048 name: renal system pattern specification namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system." [GOC:mtg_kidney_jan10] synonym: "renal system pattern formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0072049 name: comma-shaped body morphogenesis namespace: biological_process def: "The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0072028 ! nephron morphogenesis [Term] id: GO:0072050 name: S-shaped body morphogenesis namespace: biological_process def: "The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0072028 ! nephron morphogenesis [Term] id: GO:0072051 name: juxtaglomerular apparatus development namespace: biological_process def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072052 name: juxtaglomerulus cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072051 ! juxtaglomerular apparatus development [Term] id: GO:0072053 name: renal inner medulla development namespace: biological_process def: "The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney." [GOC:mtg_kidney_jan10] synonym: "inner renal medulla development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072054 name: renal outer medulla development namespace: biological_process def: "The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla." [GOC:mtg_kidney_jan10] synonym: "outer renal medulla development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072055 name: renal cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072056 name: pyramid development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10] synonym: "kidney pyramid development" EXACT [GOC:mah] synonym: "pyramids development" EXACT [GOC:mah] synonym: "renal medulla development" EXACT [GOC:mah] synonym: "renal pyramid development" EXACT [GOC:mah] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072057 name: inner stripe development namespace: biological_process def: "The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072054 ! renal outer medulla development [Term] id: GO:0072058 name: outer stripe development namespace: biological_process def: "The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072054 ! renal outer medulla development [Term] id: GO:0072059 name: cortical collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072044 ! collecting duct development [Term] id: GO:0072060 name: outer medullary collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development [Term] id: GO:0072061 name: inner medullary collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development [Term] id: GO:0072062 name: proximal convoluted tubule segment 1 cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the S1 cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "S1 cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072031 ! proximal convoluted tubule segment 1 development [Term] id: GO:0072063 name: short descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072022 ! descending thin limb development relationship: part_of GO:0072030 ! short nephron development [Term] id: GO:0072064 name: long descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072022 ! descending thin limb development relationship: part_of GO:0072029 ! long nephron development [Term] id: GO:0072065 name: long descending thin limb bend development namespace: biological_process def: "The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072064 ! long descending thin limb development [Term] id: GO:0072066 name: prebend segment development namespace: biological_process def: "The process whose specific outcome is the progression of the prebend segment over time, from its formation to the mature structure. The prebend segment is a part of the descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072022 ! descending thin limb development [Term] id: GO:0072067 name: early distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072025 ! distal convoluted tubule development [Term] id: GO:0072068 name: late distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072025 ! distal convoluted tubule development [Term] id: GO:0072069 name: DCT cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072025 ! distal convoluted tubule development [Term] id: GO:0072070 name: loop of Henle development namespace: biological_process alt_id: GO:0072018 def: "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule." [GOC:mtg_kidney_jan10] synonym: "intermediate tubule development" EXACT [] is_a: GO:0072080 ! nephron tubule development [Term] id: GO:0072071 name: renal interstitial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "kidney interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development [Term] id: GO:0072072 name: kidney stroma development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney stroma over time, from its formation to the mature structure. The kidney stroma is the mesenchyme of the mature kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development [Term] id: GO:0072073 name: kidney epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072074 name: kidney mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072075 name: metanephric mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072076 name: nephrogenic mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development relationship: part_of GO:0072006 ! nephron development [Term] id: GO:0072077 name: renal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0072028 ! nephron morphogenesis relationship: part_of GO:0072087 ! renal vesicle development relationship: part_of GO:0072088 ! nephron epithelium morphogenesis [Term] id: GO:0072078 name: nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0061333 ! renal tubule morphogenesis is_a: GO:0072088 ! nephron epithelium morphogenesis relationship: part_of GO:0072028 ! nephron morphogenesis relationship: part_of GO:0072080 ! nephron tubule development [Term] id: GO:0072079 name: nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0072078 ! nephron tubule morphogenesis [Term] id: GO:0072080 name: nephron tubule development namespace: biological_process def: "The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0061326 ! renal tubule development is_a: GO:0072009 ! nephron epithelium development [Term] id: GO:0072081 name: specification of nephron tubule identity namespace: biological_process def: "The process in which the tubules arranged along the proximal/distal axis of the nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0007379 ! segment specification relationship: part_of GO:0072047 ! proximal/distal pattern formation involved in nephron development relationship: part_of GO:0072079 ! nephron tubule formation [Term] id: GO:0072082 name: specification of proximal tubule identity namespace: biological_process def: "The process in which the proximal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072158 ! proximal tubule morphogenesis [Term] id: GO:0072084 name: specification of distal tubule identity namespace: biological_process def: "The process in which the distal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072156 ! distal tubule morphogenesis [Term] id: GO:0072085 name: specification of connecting tubule identity namespace: biological_process def: "The process in which the connecting tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072027 ! connecting tubule development [Term] id: GO:0072086 name: specification of loop of Henle identity namespace: biological_process alt_id: GO:0072083 def: "The process in which the loop of Henle of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "specification of intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072070 ! loop of Henle development [Term] id: GO:0072087 name: renal vesicle development namespace: biological_process def: "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0072009 ! nephron epithelium development [Term] id: GO:0072088 name: nephron epithelium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0072009 ! nephron epithelium development [Term] id: GO:0072089 name: stem cell proliferation namespace: biological_process def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0072090 name: mesenchymal stem cell proliferation involved in nephron morphogenesis namespace: biological_process def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072089 ! stem cell proliferation [Term] id: GO:0072091 name: regulation of stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0072089 ! stem cell proliferation [Term] id: GO:0072092 name: ureteric bud invasion namespace: biological_process def: "The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0060677 ! ureteric bud elongation relationship: part_of GO:0072093 ! metanephric renal vesicle formation [Term] id: GO:0072093 name: metanephric renal vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephros formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072033 ! renal vesicle formation relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis [Term] id: GO:0072094 name: metanephric renal vesicle induction namespace: biological_process def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle." [GOC:mtg_kidney_jan10] synonym: "positive regulation of metanephros formation" BROAD [GOC:mtg_kidney_jan10] is_a: GO:0072034 ! renal vesicle induction is_a: GO:0072216 ! positive regulation of metanephros development relationship: positively_regulates GO:0072093 ! metanephric renal vesicle formation [Term] id: GO:0072095 name: regulation of branch elongation involved in ureteric bud branching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis relationship: regulates GO:0060681 ! branch elongation involved in ureteric bud branching [Term] id: GO:0072096 name: negative regulation of branch elongation involved in ureteric bud branching namespace: biological_process def: "Any process that reduces the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0072095 ! regulation of branch elongation involved in ureteric bud branching relationship: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching [Term] id: GO:0072097 name: negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the reduction of the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10] synonym: "negative regulation of branch elongation involved in ureteric bud branching by BMP signalling pathway" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0072096 ! negative regulation of branch elongation involved in ureteric bud branching [Term] id: GO:0072098 name: anterior/posterior pattern specification involved in kidney development namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "anterior/posterior pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10] synonym: "kidney anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development [Term] id: GO:0072099 name: anterior/posterior pattern specification involved in ureteric bud development namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "ureteric bud anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development relationship: part_of GO:0001657 ! ureteric bud development [Term] id: GO:0072100 name: specification of ureteric bud anterior/posterior symmetry namespace: biological_process def: "The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10] synonym: "specification of ureteric bud anterior/posterior asymmetry" EXACT [GOC:dph] is_a: GO:0009799 ! specification of symmetry is_a: GO:0072099 ! anterior/posterior pattern specification involved in ureteric bud development [Term] id: GO:0072101 name: specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10] synonym: "specification of ureteric bud anterior/posterior asymmetry by BMP signaling pathway" EXACT [GOC:dph] synonym: "specification of ureteric bud anterior/posterior symmetry by BMP signalling pathway" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0072100 ! specification of ureteric bud anterior/posterior symmetry [Term] id: GO:0072102 name: glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0032835 ! glomerulus development [Term] id: GO:0072103 name: glomerulus vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0072012 ! glomerulus vasculature development relationship: part_of GO:0072102 ! glomerulus morphogenesis [Term] id: GO:0072104 name: glomerular capillary formation namespace: biological_process def: "The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0072103 ! glomerulus vasculature morphogenesis [Term] id: GO:0072105 name: ureteric peristalsis namespace: biological_process def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_kidney_jan10] is_a: GO:0014849 ! ureter smooth muscle contraction is_a: GO:0030432 ! peristalsis [Term] id: GO:0072106 name: regulation of ureteric bud formation namespace: biological_process def: "Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0090183 ! regulation of kidney development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0060676 ! ureteric bud formation [Term] id: GO:0072107 name: positive regulation of ureteric bud formation namespace: biological_process def: "Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0072106 ! regulation of ureteric bud formation relationship: positively_regulates GO:0060676 ! ureteric bud formation [Term] id: GO:0072108 name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation relationship: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis [Term] id: GO:0072109 name: glomerular mesangium development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072012 ! glomerulus vasculature development [Term] id: GO:0072110 name: glomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population." [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development relationship: part_of GO:0072109 ! glomerular mesangium development [Term] id: GO:0072111 name: cell proliferation involved in kidney development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072112 name: glomerular visceral epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] synonym: "podocyte differentiation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061318 ! renal filtration cell differentiation is_a: GO:0072311 ! glomerular epithelial cell differentiation [Term] id: GO:0072113 name: head kidney development namespace: biological_process def: "The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis." [GOC:mtg_kidney_jan10, ZFA:0000669] is_a: GO:0048793 ! pronephros development [Term] id: GO:0072114 name: pronephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney morphogenesis" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0060993 ! kidney morphogenesis relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0072115 name: head kidney morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] is_a: GO:0072114 ! pronephros morphogenesis relationship: part_of GO:0072113 ! head kidney development [Term] id: GO:0072116 name: pronephros formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072003 ! kidney rudiment formation relationship: part_of GO:0072114 ! pronephros morphogenesis [Term] id: GO:0072117 name: head kidney formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] is_a: GO:0072116 ! pronephros formation relationship: part_of GO:0072115 ! head kidney morphogenesis [Term] id: GO:0072118 name: pronephros structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney structural organization" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0072114 ! pronephros morphogenesis [Term] id: GO:0072119 name: head kidney structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] is_a: GO:0072118 ! pronephros structural organization relationship: part_of GO:0072115 ! head kidney morphogenesis [Term] id: GO:0072120 name: pronephros maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney maturation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048799 ! organ maturation relationship: part_of GO:0048793 ! pronephros development [Term] id: GO:0072121 name: head kidney maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] is_a: GO:0072120 ! pronephros maturation relationship: part_of GO:0072113 ! head kidney development [Term] id: GO:0072122 name: extraglomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10] synonym: "Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development relationship: part_of GO:0072006 ! nephron development [Term] id: GO:0072123 name: intraglomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10] is_a: GO:0072110 ! glomerular mesangial cell proliferation [Term] id: GO:0072124 name: regulation of glomerular mesangial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0090192 ! regulation of glomerulus development relationship: regulates GO:0072110 ! glomerular mesangial cell proliferation [Term] id: GO:0072125 name: negative regulation of glomerular mesangial cell proliferation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation relationship: negatively_regulates GO:0072110 ! glomerular mesangial cell proliferation [Term] id: GO:0072126 name: positive regulation of glomerular mesangial cell proliferation namespace: biological_process def: "Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation relationship: positively_regulates GO:0072110 ! glomerular mesangial cell proliferation [Term] id: GO:0072127 name: renal capsule development namespace: biological_process def: "The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072128 name: renal capsule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0072127 ! renal capsule development [Term] id: GO:0072129 name: renal capsule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0072128 ! renal capsule morphogenesis [Term] id: GO:0072130 name: renal capsule specification namespace: biological_process def: "The regionalization process in which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] is_a: GO:0003002 ! regionalization relationship: part_of GO:0072129 ! renal capsule formation [Term] id: GO:0072131 name: kidney mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072132 ! mesenchyme morphogenesis relationship: part_of GO:0072074 ! kidney mesenchyme development [Term] id: GO:0072132 name: mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0009887 ! organ morphogenesis relationship: part_of GO:0060485 ! mesenchyme development [Term] id: GO:0072133 name: metanephric mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072131 ! kidney mesenchyme morphogenesis relationship: part_of GO:0072075 ! metanephric mesenchyme development [Term] id: GO:0072134 name: nephrogenic mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072131 ! kidney mesenchyme morphogenesis relationship: part_of GO:0072076 ! nephrogenic mesenchyme development [Term] id: GO:0072135 name: kidney mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation is_a: GO:0072111 ! cell proliferation involved in kidney development relationship: part_of GO:0072074 ! kidney mesenchyme development [Term] id: GO:0072136 name: metanephric mesenchymal cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population." [GOC:mtg_kidney_jan10] is_a: GO:0072135 ! kidney mesenchymal cell proliferation is_a: GO:0072203 ! cell proliferation involved in metanephros development relationship: part_of GO:0072075 ! metanephric mesenchyme development [Term] id: GO:0072137 name: condensed mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0072138 name: mesenchymal cell proliferation involved in ureteric bud development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development." [GOC:mtg_kidney_jan10] synonym: "ureteric bud mesenchymal cell proliferation" BROAD [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation relationship: part_of GO:0001657 ! ureteric bud development [Term] id: GO:0072139 name: glomerular parietal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] is_a: GO:0072311 ! glomerular epithelial cell differentiation [Term] id: GO:0072140 name: DCT cell development namespace: biological_process def: "The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072069 ! DCT cell differentiation [Term] id: GO:0072141 name: renal interstitial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a renal interstitial cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "kidney interstitial cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072071 ! renal interstitial cell differentiation [Term] id: GO:0072142 name: juxtaglomerulus cell development namespace: biological_process def: "The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation [Term] id: GO:0072143 name: mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072007 ! mesangial cell differentiation [Term] id: GO:0072144 name: glomerular mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072143 ! mesangial cell development relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation [Term] id: GO:0072145 name: proximal convoluted tubule segment 1 cell development namespace: biological_process def: "The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "S1 cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation [Term] id: GO:0072146 name: DCT cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell." [GOC:mtg_kidney_jan10] synonym: "distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072069 ! DCT cell differentiation [Term] id: GO:0072147 name: glomerular parietal epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10] synonym: "Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072148 ! epithelial cell fate commitment is_a: GO:0072314 ! glomerular epithelial cell fate commitment relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation [Term] id: GO:0072148 name: epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell." [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030855 ! epithelial cell differentiation [Term] id: GO:0072149 name: glomerular visceral epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] synonym: "podocyte cell fate commitment" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072148 ! epithelial cell fate commitment is_a: GO:0072314 ! glomerular epithelial cell fate commitment relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation [Term] id: GO:0072150 name: juxtaglomerulus cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell." [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation [Term] id: GO:0072151 name: mesangial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell." [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072007 ! mesangial cell differentiation [Term] id: GO:0072152 name: glomerular mesangial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell." [GOC:mtg_kidney_jan10] is_a: GO:0072151 ! mesangial cell fate commitment relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation [Term] id: GO:0072153 name: renal interstitial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a renal interstitial cell." [GOC:mtg_kidney_jan10] synonym: "kidney interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072071 ! renal interstitial cell differentiation [Term] id: GO:0072154 name: proximal convoluted tubule segment 1 cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "S1 cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation [Term] id: GO:0072155 name: epithelial cell migration involved in nephron tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0010631 ! epithelial cell migration is_a: GO:0035787 ! cell migration involved in kidney development relationship: part_of GO:0072078 ! nephron tubule morphogenesis [Term] id: GO:0072156 name: distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis relationship: part_of GO:0072017 ! distal tubule development [Term] id: GO:0072157 name: epithelial cell migration involved in distal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis relationship: part_of GO:0072156 ! distal tubule morphogenesis [Term] id: GO:0072158 name: proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis relationship: part_of GO:0072014 ! proximal tubule development [Term] id: GO:0072159 name: epithelial cell migration involved in proximal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis relationship: part_of GO:0072158 ! proximal tubule morphogenesis [Term] id: GO:0072160 name: nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development relationship: part_of GO:0072080 ! nephron tubule development [Term] id: GO:0072161 name: mesenchymal cell differentiation involved in kidney development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0048762 ! mesenchymal cell differentiation is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072074 ! kidney mesenchyme development [Term] id: GO:0072162 name: metanephric mesenchymal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072075 ! metanephric mesenchyme development [Term] id: GO:0072163 name: mesonephric epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0001823 ! mesonephros development [Term] id: GO:0072164 name: mesonephric tubule development namespace: biological_process def: "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0072163 ! mesonephric epithelium development [Term] id: GO:0072165 name: anterior mesonephric tubule development namespace: biological_process def: "The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072164 ! mesonephric tubule development [Term] id: GO:0072166 name: posterior mesonephric tubule development namespace: biological_process def: "The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072164 ! mesonephric tubule development [Term] id: GO:0072167 name: specification of mesonephric tubule identity namespace: biological_process def: "The process in which the tubules of the mesonephros acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072172 ! mesonephric tubule formation [Term] id: GO:0072168 name: specification of anterior mesonephric tubule identity namespace: biological_process def: "The process in which the tubules of the anterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0072167 ! specification of mesonephric tubule identity relationship: part_of GO:0072165 ! anterior mesonephric tubule development [Term] id: GO:0072169 name: specification of posterior mesonephric tubule identity namespace: biological_process def: "The process in which the tubules of the posterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0072167 ! specification of mesonephric tubule identity relationship: part_of GO:0072166 ! posterior mesonephric tubule development [Term] id: GO:0072170 name: metanephric tubule development namespace: biological_process def: "The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072171 name: mesonephric tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis relationship: part_of GO:0072164 ! mesonephric tubule development [Term] id: GO:0072172 name: mesonephric tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072079 ! nephron tubule formation relationship: part_of GO:0072171 ! mesonephric tubule morphogenesis [Term] id: GO:0072173 name: metanephric tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0072170 ! metanephric tubule development [Term] id: GO:0072174 name: metanephric tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0072173 ! metanephric tubule morphogenesis [Term] id: GO:0072175 name: epithelial tube formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10] is_a: GO:0035148 ! tube formation relationship: part_of GO:0060562 ! epithelial tube morphogenesis [Term] id: GO:0072176 name: nephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development [Term] id: GO:0072177 name: mesonephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072164 ! mesonephric tubule development is_a: GO:0072176 ! nephric duct development [Term] id: GO:0072178 name: nephric duct morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0072176 ! nephric duct development [Term] id: GO:0072179 name: nephric duct formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0072178 ! nephric duct morphogenesis [Term] id: GO:0072180 name: mesonephric duct morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072171 ! mesonephric tubule morphogenesis is_a: GO:0072178 ! nephric duct morphogenesis relationship: part_of GO:0072177 ! mesonephric duct development [Term] id: GO:0072181 name: mesonephric duct formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072172 ! mesonephric tubule formation is_a: GO:0072179 ! nephric duct formation is_a: GO:0072180 ! mesonephric duct morphogenesis [Term] id: GO:0072182 name: regulation of nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0090183 ! regulation of kidney development is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development relationship: regulates GO:0072160 ! nephron tubule epithelial cell differentiation [Term] id: GO:0072183 name: negative regulation of nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development relationship: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation [Term] id: GO:0072184 name: renal vesicle progenitor cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072087 ! renal vesicle development [Term] id: GO:0072185 name: metanephric cap development namespace: biological_process def: "The biological process whose specific outcome is the progression of the metanephric cap from an initial condition to its mature state. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10] is_a: GO:0072075 ! metanephric mesenchyme development [Term] id: GO:0072186 name: metanephric cap morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric cap are generated and organized. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10] is_a: GO:0072133 ! metanephric mesenchyme morphogenesis relationship: part_of GO:0072185 ! metanephric cap development [Term] id: GO:0072187 name: metanephric cap formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0072186 ! metanephric cap morphogenesis [Term] id: GO:0072188 name: metanephric cap specification namespace: biological_process def: "The process in which the metanephric cap acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0072048 ! renal system pattern specification is_a: GO:0072187 ! metanephric cap formation [Term] id: GO:0072189 name: ureter development namespace: biological_process def: "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:mtg_kidney_jan10] is_a: GO:0048513 ! organ development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0072190 name: ureter urothelium development namespace: biological_process def: "The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter." [GOC:mtg_kidney_jan10] synonym: "ureter epithelium development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0072189 ! ureter development [Term] id: GO:0072191 name: ureter smooth muscle development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048745 ! smooth muscle tissue development relationship: part_of GO:0072189 ! ureter development [Term] id: GO:0072192 name: ureter epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter." [GOC:mtg_kidney_jan10] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0072190 ! ureter urothelium development [Term] id: GO:0072193 name: ureter smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter." [GOC:mtg_kidney_jan10] is_a: GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0072191 ! ureter smooth muscle development [Term] id: GO:0072194 name: kidney smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048745 ! smooth muscle tissue development relationship: part_of GO:0001822 ! kidney development [Term] id: GO:0072195 name: kidney smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0051145 ! smooth muscle cell differentiation is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072194 ! kidney smooth muscle tissue development [Term] id: GO:0072196 name: proximal/distal pattern formation involved in pronephric nephron development namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros." [GOC:mtg_kidney_jan10] synonym: "pronephros proximal/distal pattern formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0039017 ! pattern specification involved in pronephros development is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development [Term] id: GO:0072197 name: ureter morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder." [GOC:mtg_kidney_jan10] is_a: GO:0009887 ! organ morphogenesis is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0072189 ! ureter development [Term] id: GO:0072198 name: mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development." [GOC:mtg_kidney_jan10] synonym: "ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation relationship: part_of GO:0072189 ! ureter development [Term] id: GO:0072199 name: regulation of mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] synonym: "regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development [Term] id: GO:0072200 name: negative regulation of mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] synonym: "negative regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "negative regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation relationship: negatively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development [Term] id: GO:0072201 name: negative regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation relationship: negatively_regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0072202 name: cell differentiation involved in metanephros development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state." [GOC:mah, GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072203 name: cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072204 name: cell-cell signaling involved in metanephros development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in metanephros development" EXACT [GOC:mah] is_a: GO:0060995 ! cell-cell signaling involved in kidney development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072205 name: metanephric collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072206 name: metanephric juxtaglomerular apparatus development namespace: biological_process def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10] is_a: GO:0072051 ! juxtaglomerular apparatus development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072207 name: metanephric epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072208 name: metanephric smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072194 ! kidney smooth muscle tissue development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072209 name: metanephric mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072007 ! mesangial cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development [Term] id: GO:0072210 name: metanephric nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072211 name: metanephric pyramids development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10] synonym: "metanephric kidney pyramid development" EXACT [GOC:mah] synonym: "metanephric pyramids development" EXACT [GOC:mah] synonym: "metanephric renal medulla development" EXACT [GOC:mah] synonym: "metanephric renal pyramid development" EXACT [GOC:mah] is_a: GO:0072056 ! pyramid development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072212 name: regulation of transcription from RNA polymerase II promoter involved in metanephros development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the metanephros progresses from its initial formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072213 name: metanephric capsule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072127 ! renal capsule development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072214 name: metanephric cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072055 ! renal cortex development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072215 name: regulation of metanephros development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0090183 ! regulation of kidney development relationship: regulates GO:0001656 ! metanephros development [Term] id: GO:0072216 name: positive regulation of metanephros development namespace: biological_process def: "Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:0090184 ! positive regulation of kidney development relationship: positively_regulates GO:0001656 ! metanephros development [Term] id: GO:0072217 name: negative regulation of metanephros development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:0090185 ! negative regulation of kidney development relationship: negatively_regulates GO:0001656 ! metanephros development [Term] id: GO:0072218 name: metanephric ascending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10] is_a: GO:0072021 ! ascending thin limb development relationship: part_of GO:0072236 ! metanephric loop of Henle development [Term] id: GO:0072219 name: metanephric cortical collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10] is_a: GO:0072059 ! cortical collecting duct development relationship: part_of GO:0072205 ! metanephric collecting duct development [Term] id: GO:0072220 name: metanephric descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle." [GOC:mtg_kidney_jan10] is_a: GO:0072022 ! descending thin limb development relationship: part_of GO:0072236 ! metanephric loop of Henle development [Term] id: GO:0072221 name: metanephric distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is a portion of the metanephric nephron tubule that connects the metanephric loop of Henle to the collecting duct." [GOC:mtg_kidney_jan10] is_a: GO:0072025 ! distal convoluted tubule development relationship: part_of GO:0072235 ! metanephric distal tubule development [Term] id: GO:0072222 name: metanephric early distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072067 ! early distal convoluted tubule development relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development [Term] id: GO:0072223 name: metanephric glomerular mesangium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072109 ! glomerular mesangium development relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development [Term] id: GO:0072224 name: metanephric glomerulus development namespace: biological_process def: "The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros." [GOC:mah] synonym: "metanephric glomerular development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0032835 ! glomerulus development relationship: part_of GO:0072210 ! metanephric nephron development [Term] id: GO:0072225 name: metanephric late distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072068 ! late distal convoluted tubule development relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development [Term] id: GO:0072226 name: metanephric long descending thin limb bend development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric long descending thin limb bend over time, from its formation to the mature structure. The metanephric long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072065 ! long descending thin limb bend development relationship: part_of GO:0072220 ! metanephric descending thin limb development relationship: part_of GO:0072269 ! metanephric long descending thin limb development [Term] id: GO:0072227 name: metanephric macula densa development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072024 ! macula densa development relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development [Term] id: GO:0072228 name: metanephric prebend segment development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric prebend segment over time, from its formation to the mature structure. The metanephric prebend segment is a part of the metanephric descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10] is_a: GO:0072066 ! prebend segment development relationship: part_of GO:0072220 ! metanephric descending thin limb development [Term] id: GO:0072229 name: metanephric proximal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072019 ! proximal convoluted tubule development relationship: part_of GO:0072237 ! metanephric proximal tubule development [Term] id: GO:0072230 name: metanephric proximal straight tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule." [GOC:mtg_kidney_jan10] synonym: "metanephric S3 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072020 ! proximal straight tubule development relationship: part_of GO:0072237 ! metanephric proximal tubule development [Term] id: GO:0072231 name: metanephric proximal convoluted tubule segment 1 development namespace: biological_process def: "The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "metanephric S1 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072031 ! proximal convoluted tubule segment 1 development relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development [Term] id: GO:0072232 name: metanephric proximal convoluted tubule segment 2 development namespace: biological_process def: "The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "metanephric S2 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072032 ! proximal convoluted tubule segment 2 development relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development [Term] id: GO:0072233 name: metanephric thick ascending limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10] synonym: "metanephric TAL development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072023 ! thick ascending limb development relationship: part_of GO:0072235 ! metanephric distal tubule development [Term] id: GO:0072234 name: metanephric nephron tubule development namespace: biological_process def: "The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development is_a: GO:0072170 ! metanephric tubule development is_a: GO:0072243 ! metanephric nephron epithelium development [Term] id: GO:0072235 name: metanephric distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072017 ! distal tubule development relationship: part_of GO:0072234 ! metanephric nephron tubule development [Term] id: GO:0072236 name: metanephric loop of Henle development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric intermediate tubule development" EXACT [] is_a: GO:0072070 ! loop of Henle development relationship: part_of GO:0072234 ! metanephric nephron tubule development [Term] id: GO:0072237 name: metanephric proximal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072014 ! proximal tubule development is_a: GO:0072234 ! metanephric nephron tubule development [Term] id: GO:0072238 name: metanephric long nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072029 ! long nephron development is_a: GO:0072210 ! metanephric nephron development [Term] id: GO:0072239 name: metanephric glomerulus vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10] synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072012 ! glomerulus vasculature development relationship: part_of GO:0072224 ! metanephric glomerulus development [Term] id: GO:0072240 name: metanephric DCT cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "metanephric distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072069 ! DCT cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development [Term] id: GO:0072241 name: metanephric DCT cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "metanephric distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072140 ! DCT cell development relationship: part_of GO:0072240 ! metanephric DCT cell differentiation [Term] id: GO:0072242 name: metanephric DCT cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell." [GOC:mtg_kidney_jan10] synonym: "metanephric distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072146 ! DCT cell fate commitment relationship: part_of GO:0072240 ! metanephric DCT cell differentiation [Term] id: GO:0072243 name: metanephric nephron epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072207 ! metanephric epithelium development [Term] id: GO:0072244 name: metanephric glomerular epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072010 ! glomerular epithelium development is_a: GO:0072207 ! metanephric epithelium development relationship: part_of GO:0072224 ! metanephric glomerulus development [Term] id: GO:0072245 name: metanephric glomerular parietal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation [Term] id: GO:0072246 name: metanephric glomerular parietal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] synonym: "metanephric Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072016 ! glomerular parietal epithelial cell development is_a: GO:0072313 ! metanephric glomerular epithelial cell development relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation [Term] id: GO:0072247 name: metanephric glomerular parietal epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10] synonym: "metanephric Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation [Term] id: GO:0072248 name: metanephric glomerular visceral epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric podocyte differentiation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072112 ! glomerular visceral epithelial cell differentiation is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation [Term] id: GO:0072249 name: metanephric glomerular visceral epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric podocyte development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072015 ! glomerular visceral epithelial cell development is_a: GO:0072313 ! metanephric glomerular epithelial cell development relationship: part_of GO:0072248 ! metanephric glomerular visceral epithelial cell differentiation [Term] id: GO:0072250 name: metanephric glomerular visceral epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric podocyte cell fate commitment" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072149 ! glomerular visceral epithelial cell fate commitment is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment relationship: part_of GO:0072248 ! metanephric glomerular visceral epithelial cell differentiation [Term] id: GO:0072251 name: metanephric juxtaglomerulus cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072052 ! juxtaglomerulus cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development [Term] id: GO:0072252 name: metanephric juxtaglomerulus cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072142 ! juxtaglomerulus cell development relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation [Term] id: GO:0072253 name: metanephric juxtaglomerulus cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10] is_a: GO:0072150 ! juxtaglomerulus cell fate commitment relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation [Term] id: GO:0072254 name: metanephric glomerular mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072008 ! glomerular mesangial cell differentiation is_a: GO:0072209 ! metanephric mesangial cell differentiation relationship: part_of GO:0072223 ! metanephric glomerular mesangium development [Term] id: GO:0072255 name: metanephric glomerular mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072144 ! glomerular mesangial cell development relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation [Term] id: GO:0072256 name: metanephric glomerular mesangial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular mesangial cell." [GOC:mtg_kidney_jan10] is_a: GO:0072152 ! glomerular mesangial cell fate commitment relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation [Term] id: GO:0072257 name: metanephric nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072160 ! nephron tubule epithelial cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072234 ! metanephric nephron tubule development [Term] id: GO:0072258 name: metanephric interstitial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "metanephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072071 ! renal interstitial cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development [Term] id: GO:0072259 name: metanephric interstitial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric interstitial cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "metanephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072141 ! renal interstitial cell development relationship: part_of GO:0072258 ! metanephric interstitial cell differentiation [Term] id: GO:0072260 name: metanephric interstitial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial cell." [GOC:mtg_kidney_jan10] synonym: "metanephros interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072153 ! renal interstitial cell fate commitment relationship: part_of GO:0072258 ! metanephric interstitial cell differentiation [Term] id: GO:0072261 name: metanephric extraglomerular mesangial cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10] synonym: "metanephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "metanephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072122 ! extraglomerular mesangial cell proliferation is_a: GO:0072203 ! cell proliferation involved in metanephros development relationship: part_of GO:0072210 ! metanephric nephron development [Term] id: GO:0072262 name: metanephric glomerular mesangial cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10] is_a: GO:0072110 ! glomerular mesangial cell proliferation is_a: GO:0072203 ! cell proliferation involved in metanephros development relationship: part_of GO:0072223 ! metanephric glomerular mesangium development [Term] id: GO:0072263 name: metanephric intraglomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10] is_a: GO:0072123 ! intraglomerular mesangial cell proliferation is_a: GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development [Term] id: GO:0072264 name: metanephric glomerular endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072011 ! glomerular endothelium development relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development [Term] id: GO:0072265 name: metanephric capsule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072128 ! renal capsule morphogenesis relationship: part_of GO:0072213 ! metanephric capsule development [Term] id: GO:0072266 name: metanephric capsule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072129 ! renal capsule formation relationship: part_of GO:0072265 ! metanephric capsule morphogenesis [Term] id: GO:0072267 name: metanephric capsule specification namespace: biological_process def: "The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] is_a: GO:0072130 ! renal capsule specification relationship: part_of GO:0072266 ! metanephric capsule formation [Term] id: GO:0072268 name: pattern specification involved in metanephros development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "metanephros pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "metanephros pattern specification" EXACT [GOC:mtg_kidney_jan10] synonym: "pattern formation involved in metanephros development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0072269 name: metanephric long descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072064 ! long descending thin limb development relationship: part_of GO:0072238 ! metanephric long nephron development [Term] id: GO:0072270 name: metanephric short nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10] is_a: GO:0072030 ! short nephron development is_a: GO:0072210 ! metanephric nephron development [Term] id: GO:0072271 name: metanephric short descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072063 ! short descending thin limb development relationship: part_of GO:0072270 ! metanephric short nephron development [Term] id: GO:0072272 name: proximal/distal pattern formation involved in metanephric nephron development namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10] synonym: "proximal-distal pattern formation involved in metanephric nephron development" EXACT [GOC:mtg_kidney_jan10] synonym: "proximal/distal metanephric nephron patterning" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development is_a: GO:0072268 ! pattern specification involved in metanephros development relationship: part_of GO:0072210 ! metanephric nephron development [Term] id: GO:0072273 name: metanephric nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072028 ! nephron morphogenesis relationship: part_of GO:0003338 ! metanephros morphogenesis relationship: part_of GO:0072210 ! metanephric nephron development [Term] id: GO:0072274 name: metanephric glomerular basement membrane development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10] is_a: GO:0032836 ! glomerular basement membrane development relationship: part_of GO:0072224 ! metanephric glomerulus development [Term] id: GO:0072275 name: metanephric glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072102 ! glomerulus morphogenesis relationship: part_of GO:0072224 ! metanephric glomerulus development [Term] id: GO:0072276 name: metanephric glomerulus vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072103 ! glomerulus vasculature morphogenesis relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development relationship: part_of GO:0072275 ! metanephric glomerulus morphogenesis [Term] id: GO:0072277 name: metanephric glomerular capillary formation namespace: biological_process def: "The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] is_a: GO:0072104 ! glomerular capillary formation relationship: part_of GO:0072276 ! metanephric glomerulus vasculature morphogenesis [Term] id: GO:0072278 name: metanephric comma-shaped body morphogenesis namespace: biological_process def: "The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072049 ! comma-shaped body morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis [Term] id: GO:0072279 name: convergent extension involved in metanephric nephron morphogenesis namespace: biological_process def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis [Term] id: GO:0072280 name: establishment of planar polarity involved in metanephric nephron morphogenesis namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10] synonym: "establishment of planar cell polarity involved in metanephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10] is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis [Term] id: GO:0072281 name: mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072273 ! metanephric nephron morphogenesis [Term] id: GO:0072282 name: metanephric nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis is_a: GO:0072173 ! metanephric tubule morphogenesis relationship: part_of GO:0072234 ! metanephric nephron tubule development relationship: part_of GO:0072273 ! metanephric nephron morphogenesis [Term] id: GO:0072283 name: metanephric renal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072077 ! renal vesicle morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis [Term] id: GO:0072284 name: metanephric S-shaped body morphogenesis namespace: biological_process def: "The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072050 ! S-shaped body morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis [Term] id: GO:0072285 name: mesenchymal to epithelial transition involved in metanephric renal vesicle formation namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation relationship: part_of GO:0072093 ! metanephric renal vesicle formation [Term] id: GO:0072286 name: metanephric connecting tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric connecting duct development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072027 ! connecting tubule development is_a: GO:0072234 ! metanephric nephron tubule development [Term] id: GO:0072287 name: metanephric distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072156 ! distal tubule morphogenesis is_a: GO:0072282 ! metanephric nephron tubule morphogenesis relationship: part_of GO:0072235 ! metanephric distal tubule development [Term] id: GO:0072288 name: metanephric proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072158 ! proximal tubule morphogenesis is_a: GO:0072282 ! metanephric nephron tubule morphogenesis relationship: part_of GO:0072237 ! metanephric proximal tubule development [Term] id: GO:0072289 name: metanephric nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072079 ! nephron tubule formation relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis [Term] id: GO:0072290 name: epithelial cell migration involved in metanephric nephron tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0035788 ! cell migration involved in metanephros development is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis [Term] id: GO:0072291 name: epithelial cell migration involved in metanephric distal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis [Term] id: GO:0072292 name: epithelial cell migration involved in metanephric proximal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis [Term] id: GO:0072293 name: specification of metanephric nephron tubule identity namespace: biological_process def: "The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072272 ! proximal/distal pattern formation involved in metanephric nephron development relationship: part_of GO:0072289 ! metanephric nephron tubule formation [Term] id: GO:0072294 name: specification of metanephric connecting tubule identity namespace: biological_process def: "The process in which the connecting tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072085 ! specification of connecting tubule identity is_a: GO:0072293 ! specification of metanephric nephron tubule identity relationship: part_of GO:0072286 ! metanephric connecting tubule development [Term] id: GO:0072295 name: specification of metanephric distal tubule identity namespace: biological_process def: "The process in which the distal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072084 ! specification of distal tubule identity is_a: GO:0072293 ! specification of metanephric nephron tubule identity relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis [Term] id: GO:0072296 name: specification of metanephric loop of Henle identity namespace: biological_process def: "The process in which the loop of Henle of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "specification of metanephric intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072086 ! specification of loop of Henle identity is_a: GO:0072293 ! specification of metanephric nephron tubule identity relationship: part_of GO:0072236 ! metanephric loop of Henle development [Term] id: GO:0072297 name: specification of metanephric proximal tubule identity namespace: biological_process def: "The process in which the proximal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072082 ! specification of proximal tubule identity is_a: GO:0072293 ! specification of metanephric nephron tubule identity relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis [Term] id: GO:0072298 name: regulation of metanephric glomerulus development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0001656 ! metanephros development is_a: GO:0072215 ! regulation of metanephros development is_a: GO:0090192 ! regulation of glomerulus development relationship: regulates GO:0072224 ! metanephric glomerulus development [Term] id: GO:0072299 name: negative regulation of metanephric glomerulus development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:0072298 ! regulation of metanephric glomerulus development is_a: GO:0090194 ! negative regulation of glomerulus development relationship: negatively_regulates GO:0072224 ! metanephric glomerulus development [Term] id: GO:0072300 name: positive regulation of metanephric glomerulus development namespace: biological_process def: "Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:0072298 ! regulation of metanephric glomerulus development is_a: GO:0090193 ! positive regulation of glomerulus development relationship: positively_regulates GO:0072224 ! metanephric glomerulus development [Term] id: GO:0072301 name: regulation of metanephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation is_a: GO:0072298 ! regulation of metanephric glomerulus development relationship: regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development [Term] id: GO:0072302 name: negative regulation of metanephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation relationship: negatively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development [Term] id: GO:0072303 name: positive regulation of glomerular metanephric mesangial cell proliferation namespace: biological_process def: "Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation relationship: positively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development [Term] id: GO:0072304 name: regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis namespace: biological_process def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072039 ! regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis is_a: GO:0072215 ! regulation of metanephros development relationship: regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis [Term] id: GO:0072305 name: negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis namespace: biological_process def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072040 ! negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis is_a: GO:0072304 ! regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis relationship: negatively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis [Term] id: GO:0072306 name: positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis namespace: biological_process def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephronin the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072041 ! positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis is_a: GO:0072304 ! regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis relationship: positively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis [Term] id: GO:0072307 name: regulation of metanephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation is_a: GO:0072215 ! regulation of metanephros development relationship: regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation [Term] id: GO:0072308 name: negative regulation of metanephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation is_a: GO:0072307 ! regulation of metanephric nephron tubule epithelial cell differentiation relationship: negatively_regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation [Term] id: GO:0072309 name: mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis namespace: biological_process def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis [Term] id: GO:0072310 name: glomerular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation [Term] id: GO:0072311 name: glomerular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development relationship: part_of GO:0072010 ! glomerular epithelium development [Term] id: GO:0072312 name: metanephric glomerular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072202 ! cell differentiation involved in metanephros development is_a: GO:0072311 ! glomerular epithelial cell differentiation relationship: part_of GO:0072244 ! metanephric glomerular epithelium development [Term] id: GO:0072313 name: metanephric glomerular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: part_of GO:0072312 ! metanephric glomerular epithelial cell differentiation [Term] id: GO:0072314 name: glomerular epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation [Term] id: GO:0072315 name: metanephric glomerular epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072314 ! glomerular epithelial cell fate commitment [Term] id: GO:0072316 name: alpha-glucan catabolic process involved in ascospore release from ascus namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah] subset: gosubset_prok synonym: "alpha-glucan breakdown involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "alpha-glucan catabolism involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "alpha-glucan degradation involved in ascospore release from ascus" EXACT [GOC:mah] is_a: GO:0030980 ! alpha-glucan catabolic process is_a: GO:0072000 ! extracellular polysaccharide catabolic process involved in ascospore release from ascus [Term] id: GO:0072317 name: beta-glucan catabolic process involved in ascospore release from ascus namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-glucans in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah] subset: gosubset_prok synonym: "beta-glucan breakdown involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "beta-glucan catabolism involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "beta-glucan degradation involved in ascospore release from ascus" EXACT [GOC:mah] is_a: GO:0051275 ! beta-glucan catabolic process is_a: GO:0072000 ! extracellular polysaccharide catabolic process involved in ascospore release from ascus [Term] id: GO:0072318 name: clathrin coat disassembly namespace: biological_process def: "The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system." [PMID:11084334, PMID:11146663, PMID:8524399] synonym: "clathrin-coat disassembly" EXACT [GOC:rb] synonym: "clathrin-coat uncoating" EXACT [GOC:rb] synonym: "clathrin-coated vesicle uncoating" EXACT [GOC:mah] is_a: GO:0072319 ! vesicle uncoating [Term] id: GO:0072319 name: vesicle uncoating namespace: biological_process def: "A protein depolymerization process that results in the disassembly of vesicle coat proteins." [GOC:mah] synonym: "vesicle coat disassembly" EXACT [GOC:mah] is_a: GO:0051261 ! protein depolymerization relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0072320 name: volume-sensitive chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:mah] is_a: GO:0005225 ! volume-sensitive anion channel activity is_a: GO:0005254 ! chloride channel activity [Term] id: GO:0072321 name: chaperone-mediated protein transport namespace: biological_process def: "The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins." [GOC:mah, PMID:20378773] is_a: GO:0015031 ! protein transport [Term] id: GO:0072322 name: protein transport across periplasmic space namespace: biological_process def: "The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane or cell wall." [GOC:mah] is_a: GO:0015031 ! protein transport [Term] id: GO:0072323 name: chaperone-mediated protein transport across periplasmic space namespace: biological_process def: "The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane, mediated by chaperone molecules that bind to the transported proteins. This process has been observed in Gram-negative bacteria." [GOC:mah, PMID:20378773] is_a: GO:0072321 ! chaperone-mediated protein transport is_a: GO:0072322 ! protein transport across periplasmic space [Term] id: GO:0072324 name: ascus epiplasm namespace: cellular_component def: "An extracellular part that consist of ascus cytoplasm that is not packaged into ascospores." [DOI:10.1016/S0953-7562(96)80057-8] comment: Note that this term is an is_a child of 'extracellular region part' because it is part of the ascus that lies external to spores, each of which is a cell. is_a: GO:0044421 ! extracellular region part [Term] id: GO:0072325 name: vulval cell fate commitment namespace: biological_process def: "The process in which the cellular identity of nematode vulval cells is acquired and determined. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0040025 ! vulval development [Term] id: GO:0072326 name: vulval cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell regardless of its environment; upon determination, the cell fate cannot be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0072325 ! vulval cell fate commitment [Term] id: GO:0072327 name: vulval cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0072325 ! vulval cell fate commitment [Term] id: GO:0072328 name: alkene binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [CHEBI:32878, GOC:mah] is_a: GO:0005488 ! binding [Term] id: GO:0072329 name: monocarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [CHEBI:25384, GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0072330 name: monocarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [CHEBI:25384, GOC:mah] synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah] synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah] synonym: "monocarboxylic acid formation" EXACT [GOC:mah] synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0072331 name: signal transduction by p53 class mediator namespace: biological_process def: "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0072332 name: signal transduction by p53 class mediator resulting in induction of apoptosis namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of apoptosis." [GOC:mah] is_a: GO:0008629 ! induction of apoptosis by intracellular signals is_a: GO:0072331 ! signal transduction by p53 class mediator [Term] id: GO:0072333 name: signal transduction by p53 class mediator resulting in induction of anoikis namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of anoikis." [GOC:BHF, GOC:mah] is_a: GO:0072332 ! signal transduction by p53 class mediator resulting in induction of apoptosis is_a: GO:2000210 ! positive regulation of anoikis [Term] id: GO:0072334 name: UDP-galactose transmembrane transport namespace: biological_process def: "The directed movement of UDP-galactose across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015785 ! UDP-galactose transport is_a: GO:0034219 ! carbohydrate transmembrane transport [Term] id: GO:0072335 name: regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt receptor signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh] synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0060828 ! regulation of canonical Wnt receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0044335 ! canonical Wnt receptor signaling pathway involved in neural crest cell differentiation [Term] id: GO:0072336 name: negative regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt receptor signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah] is_a: GO:0072335 ! regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation is_a: GO:0090090 ! negative regulation of canonical Wnt receptor signaling pathway relationship: negatively_regulates GO:0044335 ! canonical Wnt receptor signaling pathway involved in neural crest cell differentiation [Term] id: GO:0072337 name: modified amino acid transport namespace: biological_process def: "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:25359, GOC:mah] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0072338 name: cellular lactam metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:24995, GOC:mah] subset: gosubset_prok synonym: "cellular lactam metabolism" EXACT [GOC:mah] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0072339 name: cellular lactam biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:24995, GOC:mah] subset: gosubset_prok synonym: "cellular lactam anabolism" EXACT [GOC:mah] synonym: "cellular lactam biosynthesis" EXACT [GOC:mah] synonym: "cellular lactam formation" EXACT [GOC:mah] synonym: "cellular lactam synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0072338 ! cellular lactam metabolic process [Term] id: GO:0072340 name: cellular lactam catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:24995, GOC:mah] subset: gosubset_prok synonym: "cellular lactam breakdown" EXACT [GOC:mah] synonym: "cellular lactam catabolism" EXACT [GOC:mah] synonym: "cellular lactam degradation" EXACT [GOC:mah] is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072338 ! cellular lactam metabolic process [Term] id: GO:0072341 name: modified amino acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a modified amino acid." [CHEBI:25359, GOC:mah] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0072342 name: response to anion stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of anion stress, an increase or decrease in the concentration of negatively charged ions in the environment." [GOC:cvs, PMID:19641131] is_a: GO:0009651 ! response to salt stress [Term] id: GO:0072343 name: pancreatic stellate cell proliferation namespace: biological_process def: "The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus." [CL:0002410, GOC:mah, PMID:17200706] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0072344 name: rescue of stalled ribosome namespace: biological_process def: "A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex." [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543] subset: gosubset_prok is_a: GO:0006414 ! translational elongation is_a: GO:0006417 ! regulation of translation [Term] id: GO:0072345 name: NAADP-sensitive calcium-release channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts." [PMID:19387438, PMID:19557428] is_a: GO:0005218 ! intracellular ligand-gated calcium channel activity [Term] id: GO:0072346 name: cADPR-sensitive calcium-release channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts." [PMID:11752598] is_a: GO:0005218 ! intracellular ligand-gated calcium channel activity [Term] id: GO:0072347 name: response to anesthetic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart] synonym: "response to anaesthetic" EXACT [GOC:mah] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0072348 name: sulfur compound transport namespace: biological_process def: "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "sulfur-containing compound transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport [Term] id: GO:0072349 name: modified amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of modified amino acids from one side of a membrane to the other." [CHEBI:25359, GOC:mah] subset: gosubset_prok synonym: "modified amino acid transporter activity" BROAD [GOC:mah] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0072350 name: tricarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." [CHEBI:27093, GOC:mah] subset: gosubset_prok synonym: "tricarboxylic acid metabolism" EXACT [GOC:mah] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0072351 name: tricarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [CHEBI:27093, GOC:mah] subset: gosubset_prok synonym: "tricarboxylate biosynthesis" EXACT [GOC:mah] synonym: "tricarboxylate biosynthetic process" EXACT [GOC:mah] synonym: "tricarboxylic acid anabolism" EXACT [GOC:mah] synonym: "tricarboxylic acid biosynthesis" EXACT [GOC:mah] synonym: "tricarboxylic acid formation" EXACT [GOC:mah] synonym: "tricarboxylic acid synthesis" EXACT [GOC:mah] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] id: GO:0072352 name: tricarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [CHEBI:27093, GOC:mah] subset: gosubset_prok synonym: "tricarboxylate catabolic process" EXACT [GOC:mah] synonym: "tricarboxylate catabolism" EXACT [GOC:mah] synonym: "tricarboxylic acid breakdown" EXACT [GOC:mah] synonym: "tricarboxylic acid catabolism" EXACT [GOC:mah] synonym: "tricarboxylic acid degradation" EXACT [GOC:mah] is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] id: GO:0072353 name: cellular age-dependent response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:mah] is_a: GO:0001315 ! age-dependent response to reactive oxygen species is_a: GO:0034614 ! cellular response to reactive oxygen species [Term] id: GO:0072354 name: histone kinase activity (H3-T3 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the threonine-3 residue of the N-terminal tail of histone H3." [GOC:mah] synonym: "histone threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah] synonym: "histone-threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah] is_a: GO:0035184 ! histone threonine kinase activity [Term] id: GO:0072355 name: histone H3-T3 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 3 of the histone." [GOC:mah] is_a: GO:0035405 ! histone-threonine phosphorylation [Term] id: GO:0072356 name: chromosome passenger complex localization to kinetochore namespace: biological_process def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis." [GOC:mah] synonym: "chromosomal passenger complex localization to kinetochore" EXACT [GOC:mah] synonym: "chromosome passenger complex localisation to kinetochore" RELATED [GOC:mah] synonym: "CPC complex localization to kinetochore" EXACT [GOC:vw] synonym: "CPC localization to kinetochore" EXACT [GOC:mah] is_a: GO:0034501 ! protein localization to kinetochore is_a: GO:0034629 ! cellular protein complex localization [Term] id: GO:0072357 name: PTW/PP1 phosphatase complex namespace: cellular_component def: "A protein serine/threonine phosphatase complex that contains a catalytic subunits (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061] is_a: GO:0008287 ! protein serine/threonine phosphatase complex [Term] id: GO:0072358 name: cardiovascular system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels." [GOC:mah, UBERON:0004535] is_a: GO:0048731 ! system development relationship: part_of GO:0072359 ! circulatory system development [Term] id: GO:0072359 name: circulatory system development namespace: biological_process def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] is_a: GO:0048731 ! system development [Term] id: GO:0072360 name: vascular cord development namespace: biological_process def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072358 ! cardiovascular system development [Term] id: GO:0072361 name: regulation of glycolysis by regulation of transcription from an RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycolysis by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] is_a: GO:0006110 ! regulation of glycolysis is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter [Term] id: GO:0072362 name: regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycolysis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0072361 ! regulation of glycolysis by regulation of transcription from an RNA polymerase II promoter [Term] id: GO:0072363 name: regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycolysis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0072361 ! regulation of glycolysis by regulation of transcription from an RNA polymerase II promoter [Term] id: GO:0072364 name: regulation of cellular ketone metabolic process by regulation of transcription from an RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] synonym: "regulation of cellular ketone metabolism by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0010565 ! regulation of cellular ketone metabolic process [Term] id: GO:0072365 name: regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] synonym: "regulation of cellular ketone metabolism by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from an RNA polymerase II promoter [Term] id: GO:0072366 name: regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] synonym: "regulation of cellular ketone metabolism by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from an RNA polymerase II promoter [Term] id: GO:0072367 name: regulation of lipid transport by regulation of transcription from an RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid transport by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0032368 ! regulation of lipid transport [Term] id: GO:0072368 name: regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0072367 ! regulation of lipid transport by regulation of transcription from an RNA polymerase II promoter [Term] id: GO:0072369 name: regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0072367 ! regulation of lipid transport by regulation of transcription from an RNA polymerase II promoter [Term] id: GO:0072370 name: histone H2A-S121 phosphorylation namespace: biological_process def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 121 of the histone." [GOC:mah, PMID:19965387] synonym: "histone H2A phosphorylation at S121" EXACT [GOC:mah] synonym: "histone H2AS121 phosphorylation" EXACT [GOC:mah] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0072371 name: histone kinase activity (H2A-S121 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-121 residue of the N-terminal tail of histone H2A." [GOC:mah, PMID:19965387] synonym: "histone serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah] synonym: "histone-serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah] is_a: GO:0035174 ! histone serine kinase activity [Term] id: GO:0072372 name: primary cilium namespace: cellular_component def: "A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors." [GOC:curators, PMID:17009929, PMID:20144998] is_a: GO:0005929 ! cilium [Term] id: GO:0072373 name: alpha-carotene epsilon hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O." [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962] xref: EC:1.14.99.- is_a: GO:0072374 ! carotene epsilon hydroxylase activity [Term] id: GO:0072374 name: carotene epsilon hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962] xref: EC:1.14.99.- is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0072375 name: medium-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375] synonym: "middle-term memory" EXACT [GOC:sart] synonym: "MTM" NARROW [GOC:sart] is_a: GO:0007613 ! memory [Term] id: GO:0072376 name: protein activation cascade namespace: biological_process def: "A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events." [GOC:add, GOC:mah, GOC:pde] synonym: "protein activation pathway" EXACT [GOC:add] synonym: "protein activitory cascade" EXACT [GOC:add] is_a: GO:0019538 ! protein metabolic process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0072377 name: blood coagulation, common pathway namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex." [GOC:add, GOC:mah, GOC:pde, PMID:1931959] comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation [Term] id: GO:0072378 name: blood coagulation, fibrin clot formation namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events." [GOC:add, GOC:mah, GOC:pde] comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0007596 ! blood coagulation [Term] id: GO:0072379 name: ER membrane insertion complex namespace: cellular_component def: "A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast." [GOC:mah, PMID:20676083, PMID:20850366] synonym: "endoplasmic reticulum membrane insertion complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0072380 name: TRC complex namespace: cellular_component def: "An ER membrane insertion complex that contains subunits that recognize two types of transmembrane domain signals. In budding yeast the complex contains Get4p, Get5p, Sgt2p, and at least two heat shock proteins (HSPs)." [GOC:mah, PMID:20850366] synonym: "TMD recognition complex" EXACT [PMID:20850366] is_a: GO:0072379 ! ER membrane insertion complex [Term] id: GO:0072381 name: positive regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt receptor signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mah] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah] is_a: GO:0072335 ! regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation is_a: GO:0090263 ! positive regulation of canonical Wnt receptor signaling pathway relationship: positively_regulates GO:0044335 ! canonical Wnt receptor signaling pathway involved in neural crest cell differentiation [Term] id: GO:0072382 name: minus-end-directed vesicle transport along microtubule namespace: biological_process def: "The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah] synonym: "microtubule minus-end-directed vesicle distribution" NARROW [GOC:rl] synonym: "microtubule minus-end-directed vesicle localization" EXACT [GOC:rl] is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0072385 ! minus-end-directed organelle transport along microtubule [Term] id: GO:0072383 name: plus-end-directed vesicle transport along microtubule namespace: biological_process def: "The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah] synonym: "microtubule plus-end-directed vesicle distribution" NARROW [GOC:rl] synonym: "microtubule plus-end-directed vesicle localization" EXACT [GOC:rl] is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0072386 ! plus-end-directed organelle transport along microtubule [Term] id: GO:0072384 name: organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] synonym: "microtubule-based organelle localization" EXACT [GOC:rl] is_a: GO:0010970 ! microtubule-based transport [Term] id: GO:0072385 name: minus-end-directed organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah] synonym: "microtubule minus-end-directed organelle distribution" NARROW [GOC:rl] synonym: "microtubule minus-end-directed organelle localization" EXACT [GOC:rl] is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0072386 name: plus-end-directed organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah] synonym: "microtubule plus-end-directed organelle distribution" NARROW [GOC:rl] synonym: "microtubule plus-end-directed organelle localization" EXACT [GOC:rl] is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0072387 name: flavin adenine dinucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:24040, GOC:mah] synonym: "FAD or FADH2 metabolic process" EXACT [GOC:curators] synonym: "flavin adenine dinucleotide metabolism" EXACT [GOC:curators] synonym: "flavin-adenine dinucleotide metabolic process" EXACT [GOC:curators] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process [Term] id: GO:0072388 name: flavin adenine dinucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:24040, GOC:mah] synonym: "FAD or FADH2 biosynthetic process" EXACT [GOC:curators] synonym: "flavin adenine dinucleotide anabolism" EXACT [GOC:curators] synonym: "flavin adenine dinucleotide biosynthesis" EXACT [GOC:curators] synonym: "flavin adenine dinucleotide formation" EXACT [GOC:curators] synonym: "flavin adenine dinucleotide synthesis" EXACT [GOC:curators] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process [Term] id: GO:0072389 name: flavin adenine dinucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:24040, GOC:mah] synonym: "FAD or FADH2 catabolic process" EXACT [GOC:curators] synonym: "flavin adenine dinucleotide breakdown" EXACT [GOC:curators] synonym: "flavin adenine dinucleotide catabolism" EXACT [GOC:curators] synonym: "flavin adenine dinucleotide degradation" EXACT [GOC:curators] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process [Term] id: GO:0072390 name: phenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [CHEBI:15882, GOC:mah] is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0072391 name: phenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [CHEBI:15882, GOC:mah] is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072390 ! phenol metabolic process [Term] id: GO:0072392 name: phenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [CHEBI:15882, GOC:mah] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0072390 ! phenol metabolic process [Term] id: GO:0072393 name: microtubule anchoring at microtubule organizing center namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938] synonym: "microtubule anchoring at microtubule organising centre" EXACT [GOC:mah] synonym: "microtubule anchoring at MTOC" EXACT [GOC:BHF] is_a: GO:0034453 ! microtubule anchoring [Term] id: GO:0072394 name: detection of stimulus involved in cell cycle checkpoint namespace: biological_process def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a cell cycle checkpoint." [GOC:mah] synonym: "cell cycle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "cell cycle checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in cell cycle checkpoint" RELATED [GOC:mah] is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0000075 ! cell cycle checkpoint [Term] id: GO:0072395 name: signal transduction involved in cell cycle checkpoint namespace: biological_process def: "A signal transduction process that contributes to a cell cycle checkpoint." [GOC:mah] is_a: GO:0035556 ! intracellular signal transduction relationship: part_of GO:0000075 ! cell cycle checkpoint [Term] id: GO:0072396 name: response to cell cycle checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of cell cycle checkpoint signaling; contributes to a cell cycle checkpoint." [GOC:mah] synonym: "cell cycle checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in cell cycle checkpoint" EXACT [GOC:mah] is_a: GO:0071216 ! cellular response to biotic stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus relationship: part_of GO:0000075 ! cell cycle checkpoint [Term] id: GO:0072397 name: detection of stimulus involved in cytokinesis checkpoint namespace: biological_process def: "The series of events in which information about the formation and integrity of cytokinetic structures, such as the contractile ring, is received and converted into a molecular signal, contributing to a cytokinesis checkpoint." [GOC:mah] synonym: "cytokinesis checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "cytokinesis checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in cytokinesis checkpoint" RELATED [GOC:mah] is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint relationship: part_of GO:0031565 ! cytokinesis checkpoint [Term] id: GO:0072398 name: signal transduction involved in cytokinesis checkpoint namespace: biological_process def: "A signal transduction process that contributes to a cytokinesis checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint relationship: part_of GO:0031565 ! cytokinesis checkpoint [Term] id: GO:0072399 name: response to cytokinesis checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of cytokinesis checkpoint signaling; contributes to a cytokinesis checkpoint." [GOC:mah] synonym: "cytokinesis checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in cytokinesis checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signal relationship: part_of GO:0031565 ! cytokinesis checkpoint [Term] id: GO:0072400 name: detection of stimulus involved in DNA integrity checkpoint namespace: biological_process def: "The series of events in which information about changes in DNA structure is received and converted into a molecular signal, contributing to a DNA integrity checkpoint." [GOC:mah] synonym: "DNA integrity checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "DNA integrity checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in DNA integrity checkpoint" RELATED [GOC:mah] is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint relationship: part_of GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0072401 name: signal transduction involved in DNA integrity checkpoint namespace: biological_process def: "A signal transduction process that contributes to a DNA integrity checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint relationship: part_of GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0072402 name: response to DNA integrity checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of DNA integrity checkpoint signaling; contributes to a DNA integrity checkpoint." [GOC:mah] synonym: "DNA integrity checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in DNA integrity checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signal relationship: part_of GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0072403 name: detection of stimulus involved in G1/S transition checkpoint namespace: biological_process def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a G1/S transition checkpoint." [GOC:mah] synonym: "G1/S transition checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "G1/S transition checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in G1/S transition checkpoint" RELATED [GOC:mah] is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint relationship: part_of GO:0071779 ! G1/S transition checkpoint [Term] id: GO:0072404 name: signal transduction involved in G1/S transition checkpoint namespace: biological_process def: "A signal transduction process that contributes to a G1/S transition checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint relationship: part_of GO:0071779 ! G1/S transition checkpoint [Term] id: GO:0072405 name: response to G1/S transition checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of G1/S transition checkpoint signaling; contributes to a G1/S transition checkpoint." [GOC:mah] synonym: "G1/S transition checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in G1/S transition checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signal relationship: part_of GO:0071779 ! G1/S transition checkpoint [Term] id: GO:0072406 name: detection of stimulus involved in G2/M transition checkpoint namespace: biological_process def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a G2/M transition checkpoint." [GOC:mah] synonym: "G2/M transition checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "G2/M transition checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in G2/M transition checkpoint" RELATED [GOC:mah] is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint relationship: part_of GO:0031576 ! G2/M transition checkpoint [Term] id: GO:0072407 name: signal transduction involved in G2/M transition checkpoint namespace: biological_process def: "A signal transduction process that contributes to a G2/M transition checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint relationship: part_of GO:0031576 ! G2/M transition checkpoint [Term] id: GO:0072408 name: response to G2/M transition checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of G2/M transition checkpoint signaling; contributes to a G2/M transition checkpoint." [GOC:mah] synonym: "G2/M transition checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in G2/M transition checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signal relationship: part_of GO:0031576 ! G2/M transition checkpoint [Term] id: GO:0072409 name: detection of stimulus involved in meiotic cell cycle checkpoint namespace: biological_process def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a meiotic cell cycle checkpoint." [GOC:mah] synonym: "meiotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "meiotic cell cycle checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in meiotic cell cycle checkpoint" RELATED [GOC:mah] is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint relationship: part_of GO:0033313 ! meiotic cell cycle checkpoint [Term] id: GO:0072410 name: response to meiotic cell cycle checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint." [GOC:mah] synonym: "meiotic cell cycle checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in meiotic cell cycle checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signal relationship: part_of GO:0033313 ! meiotic cell cycle checkpoint [Term] id: GO:0072411 name: signal transduction involved in meiotic cell cycle checkpoint namespace: biological_process def: "A signal transduction process that contributes to a meiotic cell cycle checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint relationship: part_of GO:0033313 ! meiotic cell cycle checkpoint [Term] id: GO:0072412 name: detection of stimulus involved in mitotic cell cycle checkpoint namespace: biological_process def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic cell cycle checkpoint." [GOC:mah] synonym: "mitotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle checkpoint" RELATED [GOC:mah] is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint relationship: part_of GO:0007093 ! mitotic cell cycle checkpoint [Term] id: GO:0072413 name: signal transduction involved in mitotic cell cycle checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint relationship: part_of GO:0007093 ! mitotic cell cycle checkpoint [Term] id: GO:0072414 name: response to mitotic cell cycle checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic cell cycle checkpoint signaling; contributes to a mitotic cell cycle checkpoint." [GOC:mah] synonym: "mitotic cell cycle checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic cell cycle checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signal relationship: part_of GO:0007093 ! mitotic cell cycle checkpoint [Term] id: GO:0072415 name: detection of stimulus involved in spindle checkpoint namespace: biological_process def: "The series of events in which information about the assembly, orientation or integrity of the spindle is received and converted into a molecular signal, contributing to a spindle checkpoint." [GOC:mah] synonym: "sensing involved in spindle checkpoint" RELATED [GOC:mah] synonym: "spindle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "spindle checkpoint sensor process" RELATED [GOC:mah] is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint relationship: part_of GO:0031577 ! spindle checkpoint [Term] id: GO:0072416 name: signal transduction involved in spindle checkpoint namespace: biological_process def: "A signal transduction process that contributes to a spindle checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint relationship: part_of GO:0031577 ! spindle checkpoint [Term] id: GO:0072417 name: response to spindle checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of spindle checkpoint signaling; contributes to a spindle checkpoint." [GOC:mah] synonym: "response to signal involved in spindle checkpoint" EXACT [GOC:mah] synonym: "spindle checkpoint effector process" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signal relationship: part_of GO:0031577 ! spindle checkpoint [Term] id: GO:0072418 name: detection of stimulus involved in septin checkpoint namespace: biological_process def: "The series of events in which information about the formation and integrity of the septin ring is received and converted into a molecular signal, contributing to a septin checkpoint." [GOC:mah] synonym: "sensing involved in septin checkpoint" RELATED [GOC:mah] synonym: "septin checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "septin checkpoint sensor process" RELATED [GOC:mah] is_a: GO:0072397 ! detection of stimulus involved in cytokinesis checkpoint relationship: part_of GO:0000135 ! septin checkpoint [Term] id: GO:0072419 name: signal transduction involved in septin checkpoint namespace: biological_process def: "A signal transduction process that contributes to a septin checkpoint." [GOC:mah] is_a: GO:0072398 ! signal transduction involved in cytokinesis checkpoint relationship: part_of GO:0000135 ! septin checkpoint [Term] id: GO:0072420 name: response to septin checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of septin checkpoint signaling; contributes to a v checkpoint." [GOC:mah] synonym: "response to signal involved in septin checkpoint" EXACT [GOC:mah] synonym: "septin checkpoint effector process" EXACT [GOC:mah] is_a: GO:0072399 ! response to cytokinesis checkpoint signal relationship: part_of GO:0000135 ! septin checkpoint [Term] id: GO:0072421 name: detection of DNA damage stimulus involved in DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a DNA damage checkpoint." [GOC:mah] synonym: "DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0042769 ! DNA damage response, detection of DNA damage is_a: GO:0072400 ! detection of stimulus involved in DNA integrity checkpoint relationship: part_of GO:0000077 ! DNA damage checkpoint [Term] id: GO:0072422 name: signal transduction involved in DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah] is_a: GO:0042770 ! signal transduction in response to DNA damage is_a: GO:0072401 ! signal transduction involved in DNA integrity checkpoint relationship: part_of GO:0000077 ! DNA damage checkpoint [Term] id: GO:0072423 name: response to DNA damage checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of DNA damage checkpoint signaling; contributes to a DNA damage checkpoint." [GOC:mah] synonym: "DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072402 ! response to DNA integrity checkpoint signal relationship: part_of GO:0000077 ! DNA damage checkpoint [Term] id: GO:0072424 name: detection of DNA damage stimulus involved in G2/M transition DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a G2/M transition DNA damage checkpoint." [GOC:mah] synonym: "G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "G2/M transition DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in G2/M transition DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0072406 ! detection of stimulus involved in G2/M transition checkpoint is_a: GO:0072421 ! detection of DNA damage stimulus involved in DNA damage checkpoint relationship: part_of GO:0031572 ! G2/M transition DNA damage checkpoint [Term] id: GO:0072425 name: signal transduction involved in G2/M transition DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to a G2/M transition DNA damage checkpoint." [GOC:mah] is_a: GO:0072407 ! signal transduction involved in G2/M transition checkpoint is_a: GO:0072422 ! signal transduction involved in DNA damage checkpoint relationship: part_of GO:0031572 ! G2/M transition DNA damage checkpoint [Term] id: GO:0072426 name: response to G2/M transition DNA damage checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling; contributes to a G2/M transition DNA damage checkpoint." [GOC:mah] synonym: "G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072408 ! response to G2/M transition checkpoint signal is_a: GO:0072423 ! response to DNA damage checkpoint signal relationship: part_of GO:0031572 ! G2/M transition DNA damage checkpoint [Term] id: GO:0072427 name: detection of DNA damage stimulus involved in intra-S DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to an intra-S DNA damage checkpoint." [GOC:mah] synonym: "intra-S DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "intra-S DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in intra-S DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0072421 ! detection of DNA damage stimulus involved in DNA damage checkpoint relationship: part_of GO:0031573 ! intra-S DNA damage checkpoint [Term] id: GO:0072428 name: signal transduction involved in intra-S DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to an intra-S DNA damage checkpoint." [GOC:mah] is_a: GO:0072422 ! signal transduction involved in DNA damage checkpoint relationship: part_of GO:0031573 ! intra-S DNA damage checkpoint [Term] id: GO:0072429 name: response to intra-S DNA damage checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of intra-S DNA damage checkpoint signaling; contributes to an intra-S DNA damage checkpoint." [GOC:mah] synonym: "intra-S DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in intra-S DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072423 ! response to DNA damage checkpoint signal relationship: part_of GO:0031573 ! intra-S DNA damage checkpoint [Term] id: GO:0072430 name: detection of DNA damage stimulus involved in mitotic cell cycle G1/S transition DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mah] synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle G1/S transition DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0072403 ! detection of stimulus involved in G1/S transition checkpoint is_a: GO:0072421 ! detection of DNA damage stimulus involved in DNA damage checkpoint is_a: GO:0072472 ! detection of stimulus involved in mitotic cell cycle G1/S checkpoint relationship: part_of GO:0031571 ! mitotic cell cycle G1/S transition DNA damage checkpoint [Term] id: GO:0072431 name: signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mah] is_a: GO:0072404 ! signal transduction involved in G1/S transition checkpoint is_a: GO:0072422 ! signal transduction involved in DNA damage checkpoint is_a: GO:0072474 ! signal transduction involved in mitotic cell cycle G1/S checkpoint relationship: part_of GO:0031571 ! mitotic cell cycle G1/S transition DNA damage checkpoint [Term] id: GO:0072432 name: response to mitotic cell cycle G1/S transition DNA damage checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic cell cycle G1/S transition DNA damage checkpoint signaling; contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mah] synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072405 ! response to G1/S transition checkpoint signal is_a: GO:0072423 ! response to DNA damage checkpoint signal is_a: GO:0072473 ! response to mitotic cell cycle G1/S checkpoint signal relationship: part_of GO:0031571 ! mitotic cell cycle G1/S transition DNA damage checkpoint [Term] id: GO:0072433 name: detection of DNA damage stimulus involved in mitotic G2/M transition DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic G2/M transition DNA damage checkpoint." [GOC:mah] synonym: "mitotic G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic G2/M transition DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic G2/M transition DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0072424 ! detection of DNA damage stimulus involved in G2/M transition DNA damage checkpoint is_a: GO:0072454 ! detection of stimulus involved in mitotic G2/M transition checkpoint relationship: part_of GO:0007095 ! mitotic cell cycle G2/M transition DNA damage checkpoint [Term] id: GO:0072434 name: signal transduction involved in mitotic G2/M transition DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic G2/M transition DNA damage checkpoint." [GOC:mah] is_a: GO:0072425 ! signal transduction involved in G2/M transition DNA damage checkpoint is_a: GO:0072456 ! signal transduction involved in mitotic G2/M transition checkpoint relationship: part_of GO:0007095 ! mitotic cell cycle G2/M transition DNA damage checkpoint [Term] id: GO:0072435 name: response to mitotic G2/M transition DNA damage checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling; contributes to a mitotic G2/M transition DNA damage checkpoint." [GOC:mah] synonym: "mitotic G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072426 ! response to G2/M transition DNA damage checkpoint signal is_a: GO:0072455 ! response to mitotic G2/M transition checkpoint signal relationship: part_of GO:0007095 ! mitotic cell cycle G2/M transition DNA damage checkpoint [Term] id: GO:0072436 name: detection of stimulus involved in DNA replication checkpoint namespace: biological_process def: "The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a DNA replication checkpoint." [GOC:mah] synonym: "DNA replication checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "DNA replication checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in DNA replication checkpoint" RELATED [GOC:mah] is_a: GO:0042769 ! DNA damage response, detection of DNA damage is_a: GO:0072400 ! detection of stimulus involved in DNA integrity checkpoint relationship: part_of GO:0000076 ! DNA replication checkpoint [Term] id: GO:0072437 name: signal transduction involved in DNA replication checkpoint namespace: biological_process def: "A signal transduction process that contributes to a DNA replication checkpoint." [GOC:mah] is_a: GO:0072401 ! signal transduction involved in DNA integrity checkpoint relationship: part_of GO:0000076 ! DNA replication checkpoint [Term] id: GO:0072438 name: response to DNA replication checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of DNA replication checkpoint signaling; contributes to a DNA v checkpoint." [GOC:mah] synonym: "DNA replication checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in DNA replication checkpoint" EXACT [GOC:mah] is_a: GO:0072402 ! response to DNA integrity checkpoint signal relationship: part_of GO:0000076 ! DNA replication checkpoint [Term] id: GO:0072439 name: detection of stimulus involved in meiotic DNA replication checkpoint namespace: biological_process def: "The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a meiotic DNA replication checkpoint." [GOC:mah] synonym: "meiotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "meiotic DNA replication checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in meiotic DNA replication checkpoint" RELATED [GOC:mah] is_a: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint is_a: GO:0072436 ! detection of stimulus involved in DNA replication checkpoint relationship: part_of GO:0033315 ! meiotic cell cycle DNA replication checkpoint [Term] id: GO:0072440 name: signal transduction involved in meiotic DNA replication checkpoint namespace: biological_process def: "A signal transduction process that contributes to a meiotic DNA replication checkpoint." [GOC:mah] is_a: GO:0072411 ! signal transduction involved in meiotic cell cycle checkpoint is_a: GO:0072437 ! signal transduction involved in DNA replication checkpoint relationship: part_of GO:0033315 ! meiotic cell cycle DNA replication checkpoint [Term] id: GO:0072441 name: response to meiotic DNA replication checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic DNA replication checkpoint signaling; contributes to a meiotic DNA replication checkpoint." [GOC:mah] synonym: "meiotic DNA replication checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in meiotic DNA replication checkpoint" EXACT [GOC:mah] is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signal is_a: GO:0072438 ! response to DNA replication checkpoint signal relationship: part_of GO:0033315 ! meiotic cell cycle DNA replication checkpoint [Term] id: GO:0072442 name: detection of stimulus involved in mitotic DNA replication checkpoint namespace: biological_process alt_id: GO:0072445 def: "The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a mitotic DNA replication checkpoint." [GOC:mah] synonym: "detection of stimulus involved in S-M checkpoint" EXACT [] synonym: "mitotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic DNA replication checkpoint sensor process" RELATED [GOC:mah] synonym: "S-M checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "S-M checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic DNA replication checkpoint" RELATED [GOC:mah] synonym: "sensing involved in S-M checkpoint" RELATED [GOC:mah] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint is_a: GO:0072436 ! detection of stimulus involved in DNA replication checkpoint relationship: part_of GO:0033314 ! mitotic cell cycle DNA replication checkpoint [Term] id: GO:0072443 name: signal transduction involved in mitotic DNA replication checkpoint namespace: biological_process alt_id: GO:0072446 def: "A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mah] synonym: "signal transduction involved in S-M checkpoint" EXACT [] is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint is_a: GO:0072437 ! signal transduction involved in DNA replication checkpoint relationship: part_of GO:0033314 ! mitotic cell cycle DNA replication checkpoint [Term] id: GO:0072444 name: response to mitotic DNA replication checkpoint signal namespace: biological_process alt_id: GO:0072447 def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic DNA replication checkpoint signaling; contributes to a mitotic DNA replication checkpoint." [GOC:mah] synonym: "mitotic DNA replication checkpoint effector process" EXACT [GOC:mah] synonym: "response to S-M checkpoint signal" EXACT [] synonym: "response to signal involved in mitotic DNA replication checkpoint" EXACT [GOC:mah] synonym: "response to signal involved in S-M checkpoint" EXACT [GOC:mah] synonym: "S-M checkpoint effector process" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signal is_a: GO:0072438 ! response to DNA replication checkpoint signal relationship: part_of GO:0033314 ! mitotic cell cycle DNA replication checkpoint [Term] id: GO:0072448 name: detection of stimulus involved in mitotic cell cycle G1/S transition size control checkpoint namespace: biological_process def: "The series of events in which information about cell size is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition size control checkpoint." [GOC:mah] synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED [GOC:mah] is_a: GO:0072403 ! detection of stimulus involved in G1/S transition checkpoint is_a: GO:0072469 ! detection of stimulus involved in cell size control checkpoint is_a: GO:0072472 ! detection of stimulus involved in mitotic cell cycle G1/S checkpoint relationship: part_of GO:0031568 ! mitotic cell cycle G1/S transition size control checkpoint [Term] id: GO:0072449 name: response to mitotic cell cycle G1/S transition size control checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling; contributes to a mitotic cell cycle G1/S transition size control checkpoint." [GOC:mah] synonym: "mitotic cell cycle G1/S transition size control checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic cell cycle G1/S transition size control checkpoint" EXACT [GOC:mah] is_a: GO:0072405 ! response to G1/S transition checkpoint signal is_a: GO:0072470 ! response to cell size control checkpoint signal is_a: GO:0072473 ! response to mitotic cell cycle G1/S checkpoint signal relationship: part_of GO:0031568 ! mitotic cell cycle G1/S transition size control checkpoint [Term] id: GO:0072450 name: signal transduction involved in mitotic cell cycle G1/S transition size control checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle G1/S transition size control checkpoint." [GOC:mah] is_a: GO:0072404 ! signal transduction involved in G1/S transition checkpoint is_a: GO:0072471 ! signal transduction involved in cell size control checkpoint is_a: GO:0072474 ! signal transduction involved in mitotic cell cycle G1/S checkpoint relationship: part_of GO:0031568 ! mitotic cell cycle G1/S transition size control checkpoint [Term] id: GO:0072451 name: detection of stimulus involved in G2/M transition size control checkpoint namespace: biological_process def: "The series of events in which information about cell size is received and converted into a molecular signal, contributing to a G2/M transition size control checkpoint." [GOC:mah] synonym: "detection of stimulus involved in mitotic cell cycle G2/M transition size control checkpoint" RELATED [GOC:mah] synonym: "G2/M transition size control checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "G2/M transition size control checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in G2/M transition size control checkpoint" RELATED [GOC:mah] is_a: GO:0072406 ! detection of stimulus involved in G2/M transition checkpoint is_a: GO:0072469 ! detection of stimulus involved in cell size control checkpoint relationship: part_of GO:0031569 ! G2/M transition size control checkpoint [Term] id: GO:0072452 name: response to G2/M transition size control checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of G2/M transition size control checkpoint signaling; contributes to a G2/M transition size control checkpoint." [GOC:mah] synonym: "G2/M transition size control checkpoint effector process" EXACT [GOC:mah] synonym: "response to mitotic cell cycle G2/M transition size control checkpoint signal" EXACT [GOC:mah] synonym: "response to signal involved in G2/M transition size control checkpoint" EXACT [GOC:mah] is_a: GO:0072408 ! response to G2/M transition checkpoint signal is_a: GO:0072470 ! response to cell size control checkpoint signal relationship: part_of GO:0031569 ! G2/M transition size control checkpoint [Term] id: GO:0072453 name: signal transduction involved in G2/M transition size control checkpoint namespace: biological_process def: "A signal transduction process that contributes to a G2/M transition size control checkpoint." [GOC:mah] synonym: "signal transduction involved in mitotic cell cycle G2/M transition size control checkpoint" EXACT [GOC:mah] is_a: GO:0072407 ! signal transduction involved in G2/M transition checkpoint is_a: GO:0072471 ! signal transduction involved in cell size control checkpoint relationship: part_of GO:0031569 ! G2/M transition size control checkpoint [Term] id: GO:0072454 name: detection of stimulus involved in mitotic G2/M transition checkpoint namespace: biological_process def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic G2/M checkpoint." [GOC:mah] synonym: "mitotic G2/M transition checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic G2/M transition checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic G2/M transition checkpoint" RELATED [GOC:mah] is_a: GO:0072406 ! detection of stimulus involved in G2/M transition checkpoint relationship: part_of GO:0071780 ! mitotic cell cycle G2/M transition checkpoint [Term] id: GO:0072455 name: response to mitotic G2/M transition checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic G2/M transition checkpoint signaling; contributes to a mitotic G2/M transition checkpoint." [GOC:mah] synonym: "mitotic G2/M transition checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic G2/M transition checkpoint" EXACT [GOC:mah] is_a: GO:0072408 ! response to G2/M transition checkpoint signal relationship: part_of GO:0071780 ! mitotic cell cycle G2/M transition checkpoint [Term] id: GO:0072456 name: signal transduction involved in mitotic G2/M transition checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic G2/M transition checkpoint." [GOC:mah] is_a: GO:0072407 ! signal transduction involved in G2/M transition checkpoint relationship: part_of GO:0071780 ! mitotic cell cycle G2/M transition checkpoint [Term] id: GO:0072457 name: detection of stimulus involved in mitotic G2/M transition decatenation checkpoint namespace: biological_process def: "The series of events in which information about whether sister chromatids are sufficiently separated is received and converted into a molecular signal, contributing to a mitotic G2/M decatenation checkpoint." [GOC:mah] synonym: "mitotic G2/M transition decatenation checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic G2/M transition decatenation checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah] is_a: GO:0072454 ! detection of stimulus involved in mitotic G2/M transition checkpoint relationship: part_of GO:0070683 ! mitotic cell cycle G2/M transition decatenation checkpoint [Term] id: GO:0072458 name: response to mitotic G2/M transition decatenation checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic G2/M transition decatenation checkpoint signaling; contributes to a mitotic G2/M transition decatenation checkpoint." [GOC:mah] synonym: "mitotic G2/M transition decatenation checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic G2/M transition decatenation checkpoint" EXACT [GOC:mah] is_a: GO:0072455 ! response to mitotic G2/M transition checkpoint signal relationship: part_of GO:0070683 ! mitotic cell cycle G2/M transition decatenation checkpoint [Term] id: GO:0072459 name: signal transduction involved in mitotic G2/M transition decatenation checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic G2/M transition decatenation checkpoint." [GOC:mah] is_a: GO:0072456 ! signal transduction involved in mitotic G2/M transition checkpoint relationship: part_of GO:0070683 ! mitotic cell cycle G2/M transition decatenation checkpoint [Term] id: GO:0072460 name: detection of stimulus involved in meiotic recombination checkpoint namespace: biological_process def: "The series of events in which information about whether recombination is complete is received and converted into a molecular signal, contributing to a meiotic recombination checkpoint." [GOC:mah] synonym: "meiotic recombination checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "meiotic recombination checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in meiotic recombination checkpoint" RELATED [GOC:mah] is_a: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint relationship: part_of GO:0051598 ! meiotic recombination checkpoint [Term] id: GO:0072461 name: response to meiotic recombination checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic recombination checkpoint signaling; contributes to a meiotic recombination checkpoint." [GOC:mah] synonym: "meiotic recombination checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in meiotic recombination checkpoint" EXACT [GOC:mah] is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signal relationship: part_of GO:0051598 ! meiotic recombination checkpoint [Term] id: GO:0072462 name: signal transduction involved in meiotic recombination checkpoint namespace: biological_process def: "A signal transduction process that contributes to a meiotic recombination checkpoint." [GOC:mah] is_a: GO:0072411 ! signal transduction involved in meiotic cell cycle checkpoint relationship: part_of GO:0051598 ! meiotic recombination checkpoint [Term] id: GO:0072463 name: detection of stimulus involved in meiotic spindle assembly checkpoint namespace: biological_process def: "The series of events in which information about whether spindle is correctly assembled and chromosomes are attached to the spindle is received and converted into a molecular signal, contributing to a meiotic spindle assembly checkpoint." [GOC:mah] synonym: "meiotic spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "meiotic spindle assembly checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in meiotic spindle assembly checkpoint" RELATED [GOC:mah] is_a: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint is_a: GO:0072484 ! detection of stimulus involved in spindle assembly checkpoint relationship: part_of GO:0033316 ! meiotic spindle assembly checkpoint [Term] id: GO:0072464 name: response to meiotic spindle assembly checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic spindle assembly checkpoint signaling; contributes to a meiotic spindle assembly checkpoint." [GOC:mah] synonym: "meiotic spindle assembly checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in meiotic spindle assembly checkpoint" EXACT [GOC:mah] is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signal is_a: GO:0072485 ! response to spindle assembly checkpoint signal relationship: part_of GO:0033316 ! meiotic spindle assembly checkpoint [Term] id: GO:0072465 name: signal transduction involved in meiotic spindle assembly checkpoint namespace: biological_process def: "A signal transduction process that contributes to a meiotic spindle assembly checkpoint." [GOC:mah] is_a: GO:0072411 ! signal transduction involved in meiotic cell cycle checkpoint is_a: GO:0072486 ! signal transduction involved in spindle assembly checkpoint relationship: part_of GO:0033316 ! meiotic spindle assembly checkpoint [Term] id: GO:0072466 name: detection of stimulus involved in cell shape checkpoint namespace: biological_process def: "The series of events in which information about aspects of cell polarity control is received and converted into a molecular signal, contributing to a cell shape checkpoint." [GOC:mah] synonym: "cell shape checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "cell shape checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in cell shape checkpoint" RELATED [GOC:mah] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint relationship: part_of GO:0000078 ! cell shape checkpoint [Term] id: GO:0072467 name: response to cell shape checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of cell shape checkpoint signaling; contributes to a cell shape checkpoint." [GOC:mah] synonym: "cell shape checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in cell shape checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signal relationship: part_of GO:0000078 ! cell shape checkpoint [Term] id: GO:0072468 name: signal transduction involved in cell shape checkpoint namespace: biological_process def: "A signal transduction process that contributes to a cell shape checkpoint." [GOC:mah] is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint relationship: part_of GO:0000078 ! cell shape checkpoint [Term] id: GO:0072469 name: detection of stimulus involved in cell size control checkpoint namespace: biological_process def: "The series of events in which information about cell size is received and converted into a molecular signal, contributing to a cell size control checkpoint." [GOC:mah] synonym: "cell size control checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "cell size control checkpoint sensor process" RELATED [GOC:mah] synonym: "detection of stimulus involved in mitotic cell cycle cell size control checkpoint" EXACT [GOC:mah] synonym: "sensing involved in cell size control checkpoint" RELATED [GOC:mah] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint relationship: part_of GO:0031567 ! cell size control checkpoint [Term] id: GO:0072470 name: response to cell size control checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of cell size control checkpoint signaling; contributes to a cell size control checkpoint." [GOC:mah] synonym: "cell size control checkpoint effector process" EXACT [GOC:mah] synonym: "response to mitotic cell cycle cell size control checkpoint signal" EXACT [GOC:mah] synonym: "response to signal involved in cell size control checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signal relationship: part_of GO:0031567 ! cell size control checkpoint [Term] id: GO:0072471 name: signal transduction involved in cell size control checkpoint namespace: biological_process def: "A signal transduction process that contributes to a cell size control checkpoint." [GOC:mah] is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint relationship: part_of GO:0031567 ! cell size control checkpoint [Term] id: GO:0072472 name: detection of stimulus involved in mitotic cell cycle G1/S checkpoint namespace: biological_process def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S checkpoint." [GOC:mah] synonym: "mitotic cell cycle G1/S checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle G1/S checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint relationship: part_of GO:0031575 ! mitotic cell cycle G1/S transition checkpoint [Term] id: GO:0072473 name: response to mitotic cell cycle G1/S checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic cell cycle G1/S checkpoint signaling; contributes to a mitotic cell cycle G1/S checkpoint." [GOC:mah] synonym: "mitotic cell cycle G1/S checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic cell cycle G1/S checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signal relationship: part_of GO:0031575 ! mitotic cell cycle G1/S transition checkpoint [Term] id: GO:0072474 name: signal transduction involved in mitotic cell cycle G1/S checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle G1/S checkpoint." [GOC:mah] is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint relationship: part_of GO:0031575 ! mitotic cell cycle G1/S transition checkpoint [Term] id: GO:0072475 name: detection of stimulus involved in mitotic cell cycle spindle checkpoint namespace: biological_process def: "The series of events in which information about whether the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle checkpoint." [GOC:mah] synonym: "mitotic cell cycle spindle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle spindle checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle spindle checkpoint" RELATED [GOC:mah] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint is_a: GO:0072415 ! detection of stimulus involved in spindle checkpoint relationship: part_of GO:0071174 ! mitotic cell cycle spindle checkpoint [Term] id: GO:0072476 name: response to mitotic cell cycle spindle checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling; contributes to a mitotic cell cycle spindle checkpoint." [GOC:mah] synonym: "mitotic cell cycle spindle checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic cell cycle spindle checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signal is_a: GO:0072417 ! response to spindle checkpoint signal relationship: part_of GO:0071174 ! mitotic cell cycle spindle checkpoint [Term] id: GO:0072477 name: signal transduction involved in mitotic cell cycle spindle checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle spindle checkpoint." [GOC:mah] is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint is_a: GO:0072416 ! signal transduction involved in spindle checkpoint relationship: part_of GO:0071174 ! mitotic cell cycle spindle checkpoint [Term] id: GO:0072478 name: detection of stimulus involved in mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "The series of events in which information about whether the spindle is correctly assembled, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle assembly checkpoint." [GOC:mah] synonym: "mitotic cell cycle spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle spindle assembly checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle spindle assembly checkpoint" RELATED [GOC:mah] is_a: GO:0072475 ! detection of stimulus involved in mitotic cell cycle spindle checkpoint is_a: GO:0072484 ! detection of stimulus involved in spindle assembly checkpoint relationship: part_of GO:0007094 ! mitotic cell cycle spindle assembly checkpoint [Term] id: GO:0072479 name: response to mitotic cell cycle spindle assembly checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic cell cycle spindle assembly checkpoint signaling; contributes to a mitotic cell cycle spindle assembly checkpoint." [GOC:mah] synonym: "mitotic cell cycle spindle assembly checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic cell cycle spindle assembly checkpoint" EXACT [GOC:mah] is_a: GO:0072476 ! response to mitotic cell cycle spindle checkpoint signal is_a: GO:0072485 ! response to spindle assembly checkpoint signal relationship: part_of GO:0007094 ! mitotic cell cycle spindle assembly checkpoint [Term] id: GO:0072480 name: signal transduction involved in mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint." [GOC:mah] is_a: GO:0072477 ! signal transduction involved in mitotic cell cycle spindle checkpoint is_a: GO:0072486 ! signal transduction involved in spindle assembly checkpoint relationship: part_of GO:0007094 ! mitotic cell cycle spindle assembly checkpoint [Term] id: GO:0072481 name: detection of stimulus involved in mitotic cell cycle spindle orientation checkpoint namespace: biological_process def: "The series of events in which information about whether the spindle is correctly oriented is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle orientation checkpoint." [GOC:mah] synonym: "mitotic cell cycle spindle orientation checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle spindle orientation checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle spindle orientation checkpoint" RELATED [GOC:mah] is_a: GO:0072475 ! detection of stimulus involved in mitotic cell cycle spindle checkpoint relationship: part_of GO:0031578 ! mitotic cell cycle spindle orientation checkpoint [Term] id: GO:0072482 name: response to mitotic cell cycle spindle orientation checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling; contributes to a mitotic cell cycle spindle orientation checkpoint." [GOC:mah] synonym: "mitotic cell cycle spindle orientation checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic cell cycle spindle orientation checkpoint" EXACT [GOC:mah] is_a: GO:0072476 ! response to mitotic cell cycle spindle checkpoint signal relationship: part_of GO:0031578 ! mitotic cell cycle spindle orientation checkpoint [Term] id: GO:0072483 name: signal transduction involved in mitotic cell cycle spindle orientation checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle spindle orientation checkpoint." [GOC:mah] is_a: GO:0072477 ! signal transduction involved in mitotic cell cycle spindle checkpoint relationship: part_of GO:0031578 ! mitotic cell cycle spindle orientation checkpoint [Term] id: GO:0072484 name: detection of stimulus involved in spindle assembly checkpoint namespace: biological_process def: "The series of events in which information about spindle assembly is received and converted into a molecular signal, contributing to a spindle assembly checkpoint." [GOC:mah] synonym: "sensing involved in spindle assembly checkpoint" RELATED [GOC:mah] synonym: "spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "spindle assembly checkpoint sensor process" RELATED [GOC:mah] is_a: GO:0072415 ! detection of stimulus involved in spindle checkpoint relationship: part_of GO:0071173 ! spindle assembly checkpoint [Term] id: GO:0072485 name: response to spindle assembly checkpoint signal namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of spindle assembly checkpoint signaling; contributes to a spindle assembly checkpoint." [GOC:mah] synonym: "response to signal involved in spindle assembly checkpoint" EXACT [GOC:mah] synonym: "spindle assembly checkpoint effector process" EXACT [GOC:mah] is_a: GO:0072417 ! response to spindle checkpoint signal relationship: part_of GO:0071173 ! spindle assembly checkpoint [Term] id: GO:0072486 name: signal transduction involved in spindle assembly checkpoint namespace: biological_process def: "A signal transduction process that contributes to a spindle assembly checkpoint." [GOC:mah] is_a: GO:0072416 ! signal transduction involved in spindle checkpoint relationship: part_of GO:0071173 ! spindle assembly checkpoint [Term] id: GO:0072487 name: MSL complex namespace: cellular_component def: "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852] is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0072488 name: ammonium transmembrane transport namespace: biological_process def: "The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+." [GOC:mah] is_a: GO:0015696 ! ammonium transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0072489 name: methylammonium transmembrane transport namespace: biological_process def: "The directed movement of methylammonium across a membrane by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015843 ! methylammonium transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0072490 name: toluene-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives." [CHEBI:27024, GOC:mah] synonym: "toluene and derivative metabolic process" EXACT [GOC:mah] synonym: "toluene-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0072491 name: toluene-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives." [CHEBI:27024, GOC:mah] synonym: "toluene and derivative catabolic process" EXACT [GOC:mah] synonym: "toluene-containing compound breakdown" EXACT [GOC:mah] synonym: "toluene-containing compound catabolism" EXACT [GOC:mah] synonym: "toluene-containing compound degradation" EXACT [GOC:mah] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0072492 name: host cell mitochondrial intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope." [GOC:ecd] subset: gosubset_prok is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044190 ! host cell mitochondrial envelope [Term] id: GO:0072493 name: host cell endosome lumen namespace: cellular_component def: "The volume enclosed by the membranes of the host cell endosome." [GOC:ecd] subset: gosubset_prok synonym: "host endosome lumen" EXACT [GOC:mah] is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044174 ! host cell endosome [Term] id: GO:0072494 name: host multivesicular body namespace: cellular_component def: "A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm." [GOC:rph] subset: gosubset_prok synonym: "host cell multivesicular body" EXACT [GOC:mah] is_a: GO:0044184 ! host cell late endosome [Term] id: GO:0072495 name: host cell Cajal body namespace: cellular_component def: "A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:rph] subset: gosubset_prok synonym: "coiled body of host" EXACT [GOC:rph] synonym: "host cell coiled body" EXACT [GOC:mah] is_a: GO:0044094 ! host cell nuclear part relationship: part_of GO:0044095 ! host cell nucleoplasm [Term] id: GO:0072496 name: Pup ligase activity namespace: molecular_function def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residue of the small ubiquitin-related modifier Pup and a substrate lysine residue." [GOC:sp] synonym: "Pup conjugating enzyme activity" EXACT [GOC:mah] synonym: "Pup ligase activity" EXACT [GOC:mah] is_a: GO:0019787 ! small conjugating protein ligase activity [Term] id: GO:0072497 name: mesenchymal stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0002452, GOC:BHF] is_a: GO:0048863 ! stem cell differentiation [Term] id: GO:0072498 name: embryonic skeletal joint development namespace: biological_process def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure." [GOC:BHF, GOC:vk] is_a: GO:0048706 ! embryonic skeletal system development [Term] id: GO:0072499 name: photoreceptor cell axon guidance namespace: biological_process def: "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] synonym: "photoreceptor cell axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance [Term] id: GO:0072500 name: negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor namespace: biological_process def: "Any process in which a ligand-bound hormone receptor acts in the nucleus to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:mah] is_a: GO:0034339 ! regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor [Term] id: GO:0072501 name: cellular divalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell." [GOC:mah] comment: Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular trivalent inorganic anion homeostasis' ; GO:0072502'). is_a: GO:0030002 ! cellular anion homeostasis is_a: GO:0072505 ! divalent inorganic anion homeostasis [Term] id: GO:0072502 name: cellular trivalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell." [GOC:mah] comment: Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular divalent inorganic anion homeostasis' ; GO:0072501'). is_a: GO:0030002 ! cellular anion homeostasis is_a: GO:0072506 ! trivalent inorganic anion homeostasis [Term] id: GO:0072503 name: cellular divalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell." [GOC:mah] comment: Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular trivalent inorganic cation homeostasis' ; GO:0072504'). subset: gosubset_prok is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0072504 name: cellular trivalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of trivalent cations at the level of a cell." [GOC:mah] comment: Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular divalent inorganic cation homeostasis' ; GO:0072503'). subset: gosubset_prok is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0072508 ! trivalent inorganic cation homeostasis [Term] id: GO:0072505 name: divalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'trivalent inorganic anion homeostasis' ; GO:0072506'). is_a: GO:0055081 ! anion homeostasis [Term] id: GO:0072506 name: trivalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'divalent inorganic anion homeostasis' ; GO:0072505'). is_a: GO:0055081 ! anion homeostasis [Term] id: GO:0072507 name: divalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'trivalent inorganic cation homeostasis' ; GO:0072508'). subset: gosubset_prok is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0072508 name: trivalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of trivalent cations within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'divalent inorganic cation homeostasis' ; GO:0072507'). subset: gosubset_prok is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0072509 name: divalent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of inorganic cations with a valency of two from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:mah] subset: gosubset_prok is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0072510 name: trivalent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of inorganic cations with a valency of three from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:mah] subset: gosubset_prok is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0072511 name: divalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:mah] subset: gosubset_prok is_a: GO:0006812 ! cation transport [Term] id: GO:0072512 name: trivalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:mah] subset: gosubset_prok is_a: GO:0006812 ! cation transport [Term] id: GO:0072513 name: positive regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mah] synonym: "negative regulation of second heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0003266 ! regulation of secondary heart field cardioblast proliferation is_a: GO:0008284 ! positive regulation of cell proliferation [Term] id: GO:0072514 name: trehalose transport in response to water deprivation namespace: biological_process def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water." [GOC:mah] is_a: GO:0015771 ! trehalose transport is_a: GO:0042631 ! cellular response to water deprivation [Term] id: GO:0072515 name: trehalose transport in response to desiccation namespace: biological_process def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water." [GOC:mah] is_a: GO:0071465 ! cellular response to desiccation is_a: GO:0072514 ! trehalose transport in response to water deprivation [Term] id: GO:0072516 name: viral assembly compartment namespace: cellular_component def: "A membrane-bounded compartment that forms in the cytoplasm of virus-infected cells, in which virus assembly takes place." [GOC:BHF, PMID:20374631] synonym: "viral assembly site" RELATED [GOC:BHF] synonym: "virion assembly compartment" EXACT [GOC:mah] is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0072517 name: host cell viral assembly compartment namespace: cellular_component def: "A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place." [GOC:BHF, PMID:20374631] synonym: "host cell viral assembly site" RELATED [GOC:BHF] synonym: "host cell virion assembly compartment" EXACT [GOC:mah] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0072518 name: Rho-dependent protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires binding of the GTPase Rho." [GOC:ecd, PMID:12778124, PMID:20230755] synonym: "Rho-associated protein kinase activity" EXACT [GOC:ecd] synonym: "ROCK kinase activity" EXACT [GOC:ecd] is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0072519 name: parasitism namespace: biological_process def: "An interaction between two organisms living together in more or less intimate association in a relationship in which association is disadvantageous or destructive to one of the organisms." [GOC:curators] is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0072520 name: seminiferous tubule development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa." [GOC:BHF, GOC:mah, UBERON:0001343] is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0008584 ! male gonad development [Term] id: GO:0072521 name: purine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] synonym: "purine and derivative metabolic process" EXACT [GOC:curators] synonym: "purine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0072522 name: purine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] synonym: "purine and derivative biosynthetic process" EXACT [GOC:curators] synonym: "purine-containing compound anabolism" EXACT [GOC:mah] synonym: "purine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "purine-containing compound formation" EXACT [GOC:mah] synonym: "purine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0072523 name: purine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] synonym: "purine and derivative catabolic process" EXACT [GOC:curators] synonym: "purine-containing compound breakdown" EXACT [GOC:mah] synonym: "purine-containing compound catabolism" EXACT [GOC:mah] synonym: "purine-containing compound degradation" EXACT [GOC:mah] is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0072524 name: pyridine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah] synonym: "pyridine and derivative metabolic process" EXACT [GOC:curators] synonym: "pyridine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0072525 name: pyridine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah] synonym: "pyridine and derivative biosynthetic process" EXACT [GOC:curators] synonym: "pyridine-containing compound anabolism" EXACT [GOC:mah] synonym: "pyridine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "pyridine-containing compound formation" EXACT [GOC:mah] synonym: "pyridine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0072526 name: pyridine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah] synonym: "pyridine and derivative catabolic process" EXACT [GOC:curators] synonym: "pyridine-containing compound breakdown" EXACT [GOC:mah] synonym: "pyridine-containing compound catabolism" EXACT [GOC:mah] synonym: "pyridine-containing compound degradation" EXACT [GOC:mah] is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0072527 name: pyrimidine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] synonym: "pyrimidine and derivative metabolic process" EXACT [GOC:curators] synonym: "pyrimidine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0072528 name: pyrimidine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] synonym: "pyrimidine and derivative biosynthetic process" EXACT [GOC:curators] synonym: "pyrimidine-containing compound anabolism" EXACT [GOC:mah] synonym: "pyrimidine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "pyrimidine-containing compound formation" EXACT [GOC:mah] synonym: "pyrimidine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0072529 name: pyrimidine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] synonym: "pyrimidine and derivative catabolic process" EXACT [GOC:curators] synonym: "pyrimidine-containing compound breakdown" EXACT [GOC:mah] synonym: "pyrimidine-containing compound catabolism" EXACT [GOC:mah] synonym: "pyrimidine-containing compound degradation" EXACT [GOC:mah] is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0072530 name: purine-containing compound transmembrane transport namespace: biological_process def: "The directed movement of a purine-containing compound across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0072531 name: pyrimidine-containing compound transmembrane transport namespace: biological_process def: "The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0072532 name: tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives." [GOC:kad, PMID:19779199] comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-triferuloyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tri-(hydroxyferuloyl)-spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11262 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11262) and the KEGG reaction R08986 (http://www.genome.jp/dbget-bin/www_bget?rn:R08986). is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0072533 name: tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives." [GOC:kad, PMID:19779199] comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-tricoumaroyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tricaffeoyl spermidine +3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11260 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11260). is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0072534 name: perineuronal net namespace: cellular_component def: "A dense extracellular matrix (ECM) structure that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain." [GOC:sl, PMID:18364019] synonym: "PNN" EXACT [GOC:sl] is_a: GO:0044420 ! extracellular matrix part [Term] id: GO:0072535 name: tumor necrosis factor (ligand) superfamily member 11 production namespace: biological_process def: "The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah] synonym: "RANKL production" EXACT [GOC:ebc] synonym: "TNFSF11 production" EXACT [GOC:mah] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0072536 name: interleukin-23 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-23. The complex comprises two subunits, including the same beta subunit found in the interleukin-12 receptor." [GOC:BHF, GOC:mah, PMID:12023369] synonym: "IL-23 receptor complex" EXACT [GOC:mah] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0072537 name: fibroblast activation namespace: biological_process def: "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [CL:0000057, GOC:BHF, GOC:mah] is_a: GO:0001775 ! cell activation [Term] id: GO:0072538 name: T-helper 17 type immune response namespace: biological_process def: "An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22." [GOC:BHF, GOC:ebc] synonym: "Th17 immune response" EXACT [GOC:mah] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0072539 name: T-helper 17 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T-helper 17 cell development" RELATED [GOC:mah] is_a: GO:0042093 ! T-helper cell differentiation relationship: part_of GO:0072538 ! T-helper 17 type immune response [Term] id: GO:0072540 name: T-helper 17 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc] synonym: "T-helper 17 cell fate commitment" EXACT [GOc:mah] synonym: "Th17 cell lineage commitment" EXACT [CL:0000899, GOC:mah] synonym: "Th17 fate commitment" EXACT [CL:0000899] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0072539 ! T-helper 17 cell differentiation [Term] id: GO:0072541 name: peroxynitrite reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 R-SH + ONOO- = R-SS-R + NO2- + H2O." [GOC:rs, PMID:11001062] comment: Note that this activity is usually associated in vivo with an NADPH-dependent disulfide reductase activity, so that catalysis of the reduction of peroxynitrite to nitrite involves the possible creation of oxygen or water, using NADPH as reduction equivalent. synonym: "peroxynitritase activity" EXACT [GOC:rs] is_a: GO:0051920 ! peroxiredoxin activity [Term] id: GO:0072542 name: protein phosphatase activator activity namespace: molecular_function def: "Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [GOC:mah] is_a: GO:0019211 ! phosphatase activator activity is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0072543 name: protein phosphatase type 2A activator activity namespace: molecular_function def: "Increases the activity of the enzyme protein phosphatase type 2A." [GOC:vw] is_a: GO:0008601 ! protein phosphatase type 2A regulator activity is_a: GO:0072542 ! protein phosphatase activator activity [Term] id: GO:0072544 name: L-DOPA binding namespace: molecular_function def: "Interacting selectively with L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid." [CHEBI:15765, GOC:mah] synonym: "L-dopa binding" EXACT [CHEBI:15765] is_a: GO:0072341 ! modified amino acid binding [Term] id: GO:0072545 name: tyrosine binding namespace: molecular_function def: "Interacting selectively and non-covalently with2-amino-3-(4-hydroxyphenyl)propanoic acid." [CHEBI:18186, GOC:mah] synonym: "Tyr binding" EXACT [GOC:mah] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0072546 name: ER membrane protein complex namespace: cellular_component def: "A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [GOC:dgf, PMID:19325107] synonym: "EMC" EXACT [] synonym: "endoplasmic reticulum membrane protein complex" EXACT [GOC:mah] is_a: GO:0043234 ! protein complex relationship: part_of GO:0030176 ! integral to endoplasmic reticulum membrane [Term] id: GO:0072547 name: tricoumaroylspermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] synonym: "tricoumaroyl spermidine meta-hydroxylase activity" EXACT [GOC:mah] is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity [Term] id: GO:0072548 name: dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity [Term] id: GO:0072549 name: monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity [Term] id: GO:0072550 name: triferuloylspermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] synonym: "triferuloyl spermidine meta-hydroxylase activity" EXACT [GOC:mah] is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity [Term] id: GO:0072551 name: diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity [Term] id: GO:0072552 name: monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity [Term] id: GO:0072553 name: terminal button organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:BHF, GOC:mah] synonym: "bouton organization" EXACT [GOC:mah] synonym: "presynaptic bouton organization" EXACT [GOC:mah] synonym: "synaptic bouton organization" EXACT [GOC:mah] synonym: "terminal bouton organization" EXACT [GOC:mah] synonym: "terminal button organisation" EXACT [GOC:mah] is_a: GO:0071842 ! cellular component organization at cellular level relationship: part_of GO:0050808 ! synapse organization [Term] id: GO:0072554 name: blood vessel lumenization namespace: biological_process def: "The process in which a developing blood vessel forms an endothelial lumen through which blood will flow." [GOC:dsf, PMID:16799567, PMID:20926893] is_a: GO:0061154 ! endothelial tube morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0072555 name: 17-beta-ketosteroid reductase activity namespace: molecular_function def: "Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+." [GOC:kad, PMID:17074428] synonym: "17-beta-ketosteroid reductase (NADPH) activity" EXACT [GOC:kad] synonym: "7beta-ketosteroid reductase activity" EXACT [GOC:kad] is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0072556 name: other organism presynaptic membrane namespace: cellular_component def: "A presynaptic membrane that is part of another organism, i.e. a secondary organism with which the first organism is interacting. A presynaptic membrane is specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:mah] is_a: GO:0044218 ! other organism cell membrane [Term] id: GO:0072557 name: IPAF inflammasome complex namespace: cellular_component def: "A protein complex that consists of four components, NALP1, PYCARD (ASC)(27), caspase-1 and caspase-5, and includes among its functions that of being the primary mediator of susceptibility to anthrax lethal toxin." [GOC:add, GOC:BHF, PMID:20303873] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0072558 name: NALP1 inflammasome complex namespace: cellular_component def: "A protein complex that consists of three components, NALP3, PYCARD and caspase-1, and includes among its functions the sensing of various stimuli including anti-viral compounds R837 and R848, bacterial mRNA, gout-associated crystals, bacterial toxins derived from Listeria monocytogenes, Staphylococcus aureus and Shigella flexneri." [GOC:add, GOC:BHF, PMID:20303873] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0072559 name: NALP3 inflammasome complex namespace: cellular_component def: "A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri." [GOC:add, GOC:BHF, PMID:20303873] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0072560 name: type B pancreatic cell maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF] comment: These processes continue to 60 DPA in Gossypium spp. synonym: "pancreatic B cell maturation" EXACT [CL:0000169, GOC:mah] synonym: "pancreatic beta cell maturation" EXACT [CL:0000169, GOC:mah] is_a: GO:0048469 ! cell maturation relationship: part_of GO:0003323 ! type B pancreatic cell development [Term] id: GO:0072561 name: protein-methionine-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine S-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [GOC:mah] xref: EC:1.8.4.- is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0072562 name: blood microparticle namespace: cellular_component def: "A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids." [GOC:BHF, GOC:mah, PMID:16373184] comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain. synonym: "cell membrane microparticle" EXACT [PMID:16373184] is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0072563 name: endothelial microparticle namespace: cellular_component def: "A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184] comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain. is_a: GO:0072562 ! blood microparticle [Term] id: GO:0072564 name: blood microparticle formation namespace: biological_process def: "The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell." [GOC:BHF, GOC:mah, PMID:16373184] comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain. synonym: "microparticle generation" EXACT [PMID:20978343] synonym: "microparticle release" EXACT [PMID:16373184] is_a: GO:0016043 ! cellular component organization is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0072565 name: endothelial microparticle formation namespace: biological_process def: "The cellular component organization process in which microparticles bud off from an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184] comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain. synonym: "endothelial microparticle generation" EXACT [GOC:mah, PMID:20978343] synonym: "endothelial microparticle release" EXACT [GOC:mah, PMID:16373184] is_a: GO:0072564 ! blood microparticle formation [Term] id: GO:0072566 name: chemokine (C-X-C motif) ligand 1 production namespace: biological_process def: "The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah] synonym: "CXCL1 production" EXACT [GOC:BHF] synonym: "KC production" EXACT [GOC:BHF] synonym: "keratinocyte derived chemokine production" EXACT [GOC:BHF] synonym: "SCYB1 production" EXACT [GOC:BHF] is_a: GO:0032602 ! chemokine production [Term] id: GO:0072567 name: chemokine (C-X-C motif) ligand 2 production namespace: biological_process def: "The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah] synonym: "CXCL2 production" EXACT [GOC:mah] synonym: "MIP-2 production" EXACT [GOC:BHF] synonym: "MIP2 production" EXACT [GOC:BHF] synonym: "SCYB2 production" EXACT [GOC:BHF] is_a: GO:0032602 ! chemokine production [Term] id: GO:0072568 name: protein kinase C delta binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein kinase C delta." [GOC:BHF, PMID:17161867] synonym: "PKC delta binding" EXACT [GOC:BHF, GOC:pr] is_a: GO:0005080 ! protein kinase C binding [Term] id: GO:0072569 name: protein kinase C eta binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein kinase C eta." [GOC:BHF, PMID:17161867] synonym: "PKC eta binding" EXACT [GOC:BHF, GOC:pr] is_a: GO:0005080 ! protein kinase C binding [Term] id: GO:0072570 name: ADP-D-ribose binding namespace: molecular_function def: "Interacting selectively and non-covalently with ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [CHEBI:16864, GOC:mah, GOC:sart, PMID:20088964] synonym: "ADP-ribose binding" BROAD [GOC:mah] is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0072571 name: mono-ADP-D-ribose binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [CHEBI:16864, GOC:mah, GOC:sart, PMID:20088964] synonym: "mADPr binding" EXACT [PMID:20088964] synonym: "mono-ADP-ribose binding" BROAD [GOC:mah] is_a: GO:0005529 ! sugar binding is_a: GO:0072570 ! ADP-D-ribose binding [Term] id: GO:0072572 name: poly-ADP-D-ribose binding namespace: molecular_function def: "Interacting selectively and non-covalently with polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [CHEBI:61151, GOC:mah, GOC:sart, PMID:20088964] synonym: "pADPr binding" EXACT [PMID:20088964] synonym: "poly-ADP-ribose binding" BROAD [GOC:mah] is_a: GO:0030247 ! polysaccharide binding is_a: GO:0072570 ! ADP-D-ribose binding [Term] id: GO:0072573 name: tolerance induction to lipopolysaccharide namespace: biological_process def: "Tolerance induction directed at lipopolysaccharide antigens." [GOC:BHF, GOC:mah] synonym: "tolerance induction to endotoxin" BROAD [GOC:add, GOC:mah] synonym: "tolerance induction to LPS" EXACT [GOC:add, GOC:mah] is_a: GO:0002507 ! tolerance induction is_a: GO:0031665 ! negative regulation of lipopolysaccharide-mediated signaling pathway is_a: GO:0034144 ! negative regulation of toll-like receptor 4 signaling pathway is_a: GO:0071222 ! cellular response to lipopolysaccharide [Term] id: GO:0072574 name: hepatocyte proliferation namespace: biological_process def: "The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules." [CL:0000182, GOC:BHF, GOC:mah] is_a: GO:0072575 ! epithelial cell proliferation involved in liver morphogenesis [Term] id: GO:0072575 name: epithelial cell proliferation involved in liver morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver." [GOC:BHF, GOC:mah] is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0072576 ! liver morphogenesis [Term] id: GO:0072576 name: liver morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the liver are generated and organized." [GOC:mah] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0001889 ! liver development [Term] id: GO:0072577 name: endothelial cell apoptosis namespace: biological_process def: "The process of apoptosis in endothelial cells. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah] synonym: "apoptosis of endothelial cells" EXACT [GOC:mah] synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah] synonym: "killing of endothelial cells" EXACT [GOC:mah] synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah] synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah] is_a: GO:0006915 ! apoptosis [Term] id: GO:0072578 name: neurotransmitter-gated ion channel clustering namespace: biological_process def: "The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane." [GOC:dsf, PMID:20843816] is_a: GO:0043113 ! receptor clustering relationship: part_of GO:0007416 ! synapse assembly [Term] id: GO:0072579 name: glycine receptor clustering namespace: biological_process def: "The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane." [GOC:dsf, GOC:mah, PMID:20843816] is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering [Term] id: GO:0072580 name: bacterial-type EF-P lysine modification namespace: biological_process def: "The modification of a lysine residue in a protein, producing (2S)-2-amino-6-([(3S)-3,6-diaminohexanoyl]amino)hexanoic acid. This modification is observed in, and is probably unique to, the prokaryotic translation elongation factor P (EF-P)." [GOC:curators, GOC:mah, PMID:20729861, RESID:AA0530, RESID:AA0531] is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0072581 name: protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine namespace: biological_process def: "The modification of an N6-(lysyl)-L-lysine residue in a protein, producing protein-N6-(beta-lysyl)-L-lysine ((2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid). This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:jsg, GOC:mah, PMID:20729861, RESID:AA0531] is_a: GO:0018205 ! peptidyl-lysine modification relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification [Term] id: GO:0072582 name: 17-beta-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+." [GOC:kad, PMID:17074428] is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0072583 name: clathrin-mediated endocytosis namespace: biological_process def: "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965] synonym: "clathrin coated pit-dependent endocytosis" EXACT [GOC:BHF] synonym: "clathrin-dependent endocytosis" EXACT [GOC:mah] is_a: GO:0006897 ! endocytosis [Term] id: GO:0072584 name: caveolin-mediated endocytosis namespace: biological_process def: "An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers." [GOC:BHF, GOC:mah, PMID:17318224, PMID:18498251, PMID:8970738, PMID:9234965] synonym: "caveolae-dependent endocytosis" EXACT [GOC:mah] synonym: "caveolae-mediated endocytosis" EXACT [GOC:mah] synonym: "caveolin-dependent endocytosis" EXACT [GOC:BHF] is_a: GO:0006897 ! endocytosis [Term] id: GO:0072585 name: xanthosine nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine." [GOC:kad, MetaCyc:RXN0-363, PMID:21235647] synonym: "xanthosine ribohydrolase activity" EXACT [GOC:kad] xref: MetaCyc:RXN0-363 is_a: GO:0008477 ! purine nucleosidase activity [Term] id: GO:0072586 name: DNA topoisomerase (ATP-hydrolyzing) regulator activity namespace: molecular_function def: "Modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0072587 name: DNA topoisomerase (ATP-hydrolyzing) activator activity namespace: molecular_function def: "Increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0072586 ! DNA topoisomerase (ATP-hydrolyzing) regulator activity [Term] id: GO:0072588 name: box H/ACA RNP complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA of the box H/ACA type, a subtype of the small nucleolar RNA (snoRNA) family. RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs, although some have evolved other functions. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and on U2 small nuclear RNA (U2 snRNA)." [GOC:mah, GOC:vw, PMID:17284456, PMID:20227365] synonym: "box H/ACA snoRNP pseudouridylase complex" RELATED [GOC:mah] synonym: "sRNP complex" NARROW [GOC:mah, PMID:17284456, PMID:20227365] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex [Term] id: GO:0072589 name: box H/ACA scaRNP complex namespace: cellular_component def: "A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs." [GOC:mah, PMID:17284456, PMID:20227365] synonym: "nucleoplasmic box H/ACA RNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:20227365] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0072588 ! box H/ACA RNP complex relationship: part_of GO:0015030 ! Cajal body [Term] id: GO:0072590 name: N-acetyl-L-aspartate-L-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate." [PMID:20643647, PMID:20657015] is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0072591 name: citrate-L-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate." [PMID:20657015] is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0072592 name: oxygen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [CHEBI:33263, GOC:mah] synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263] synonym: "oxygen metabolism" EXACT [GOC:mah] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0072593 name: reactive oxygen species metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [CHEBI:26523, GOC:mah] synonym: "reactive oxygen species metabolism" EXACT [GOC:mah] synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0072594 name: establishment of protein localization to organelle namespace: biological_process def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah] is_a: GO:0045184 ! establishment of protein localization relationship: part_of GO:0033365 ! protein localization to organelle [Term] id: GO:0072595 name: maintenance of protein localization to organelle namespace: biological_process def: "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] is_a: GO:0032507 ! maintenance of protein location in cell relationship: part_of GO:0033365 ! protein localization to organelle [Term] id: GO:0072596 name: establishment of protein localization to chloroplast namespace: biological_process def: "The directed movement of a protein to a specific location in a chloroplast." [GOC:mah] synonym: "establishment of protein localisation to chloroplast" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0072598 ! protein localization to chloroplast [Term] id: GO:0072597 name: maintenance of protein location in chloroplast namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization to organelle relationship: part_of GO:0072598 ! protein localization to chloroplast [Term] id: GO:0072598 name: protein localization to chloroplast namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a chloroplast." [GOC:ecd] synonym: "protein localisation to chloroplast" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0072599 name: establishment of protein localization in endoplasmic reticulum namespace: biological_process def: "The directed movement of a protein to a specific location in the endoplasmic reticulum." [GOC:mah] synonym: "establishment of protein localisation to endoplasmic reticulum" EXACT [GOC:mah] synonym: "establishment of protein localisation to ER" EXACT [GOC:mah] synonym: "establishment of protein localization to ER" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0070972 ! protein localization in endoplasmic reticulum [Term] id: GO:0072600 name: establishment of protein localization in Golgi namespace: biological_process def: "The directed movement of a protein to a specific location in the Golgi apparatus." [GOC:mah] synonym: "establishment of protein localisation to Golgi" EXACT [GOC:mah] synonym: "establishment of protein localisation to Golgi apparatus" EXACT [GOC:mah] synonym: "establishment of protein localization to Golgi apparatus" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0034067 ! protein localization in Golgi apparatus [Term] id: GO:0072601 name: interleukin-3 secretion namespace: biological_process def: "The regulated release of interleukin-3 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-3 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032632 ! interleukin-3 production [Term] id: GO:0072602 name: interleukin-4 secretion namespace: biological_process def: "The regulated release of interleukin-4 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-4 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032633 ! interleukin-4 production [Term] id: GO:0072603 name: interleukin-5 secretion namespace: biological_process def: "The regulated release of interleukin-5 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-5 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032634 ! interleukin-5 production [Term] id: GO:0072604 name: interleukin-6 secretion namespace: biological_process def: "The regulated release of interleukin-6 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-6 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032635 ! interleukin-6 production [Term] id: GO:0072605 name: interleukin-7 secretion namespace: biological_process def: "The regulated release of interleukin-7 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-7 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032636 ! interleukin-7 production [Term] id: GO:0072606 name: interleukin-8 secretion namespace: biological_process def: "The regulated release of interleukin-8 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-8 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032637 ! interleukin-8 production [Term] id: GO:0072607 name: interleukin-9 secretion namespace: biological_process def: "The regulated release of interleukin-9 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-9 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032638 ! interleukin-9 production [Term] id: GO:0072608 name: interleukin-10 secretion namespace: biological_process def: "The regulated release of interleukin-10 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-10 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032613 ! interleukin-10 production [Term] id: GO:0072609 name: interleukin-11 secretion namespace: biological_process def: "The regulated release of interleukin-11 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-11 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032614 ! interleukin-11 production [Term] id: GO:0072610 name: interleukin-12 secretion namespace: biological_process def: "The regulated release of interleukin-12 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "CLMF secretion" NARROW [GOC:BHF] synonym: "IL-12 secretion" EXACT [GOC:BHF] synonym: "IL12 secretion" EXACT [GOC:BHF] synonym: "interleukin-12 complex secretion" EXACT [GOC:BHF] synonym: "NKSF secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032615 ! interleukin-12 production [Term] id: GO:0072611 name: interleukin-13 secretion namespace: biological_process def: "The regulated release of interleukin-13 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-13 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032616 ! interleukin-13 production [Term] id: GO:0072612 name: interleukin-14 secretion namespace: biological_process def: "The regulated release of interleukin-14 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-14 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032617 ! interleukin-14 production [Term] id: GO:0072613 name: interleukin-15 secretion namespace: biological_process def: "The regulated release of interleukin-15 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-15 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032618 ! interleukin-15 production [Term] id: GO:0072614 name: interleukin-16 secretion namespace: biological_process def: "The regulated release of interleukin-16 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-16 secretion" EXACT [GOC:BHF] synonym: "IL16 secretion" EXACT [GOC:BHF] synonym: "LCF secretion" NARROW [GOC:BHF] synonym: "pro-interleukin-16 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032619 ! interleukin-16 production [Term] id: GO:0072615 name: interleukin-17 secretion namespace: biological_process def: "The regulated release of interleukin-17 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "CTLA-8 secretion" EXACT [GOC:BHF] synonym: "Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:BHF] synonym: "IL-17 secretion" EXACT [GOC:BHF] synonym: "IL-17A secretion" EXACT [GOC:BHF] synonym: "IL17A secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032620 ! interleukin-17 production [Term] id: GO:0072616 name: interleukin-18 secretion namespace: biological_process def: "The regulated release of interleukin-18 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IGIF secretion" EXACT [GOC:BHF] synonym: "IL-18 secretion" EXACT [GOC:BHF] synonym: "IL1F4 secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032621 ! interleukin-18 production [Term] id: GO:0072617 name: interleukin-19 secretion namespace: biological_process def: "The regulated release of interleukin-19 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-19 secretion" EXACT [GOC:BHF] synonym: "ZMDA1 secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032622 ! interleukin-19 production [Term] id: GO:0072618 name: interleukin-20 secretion namespace: biological_process def: "The regulated release of interleukin-20 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-20 secretion" EXACT [GOC:BHF] synonym: "ZCYTO10 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032624 ! interleukin-20 production [Term] id: GO:0072619 name: interleukin-21 secretion namespace: biological_process def: "The regulated release of interleukin-21 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-21 secretion" EXACT [GOC:BHF] synonym: "IL21 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032625 ! interleukin-21 production [Term] id: GO:0072620 name: interleukin-22 secretion namespace: biological_process def: "The regulated release of interleukin-22 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-22 secretion" EXACT [GOC:BHF] synonym: "IL22 secretion" EXACT [GOC:BHF] synonym: "ILTIF secretion" EXACT [GOC:BHF] synonym: "ZCYTO18 secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032626 ! interleukin-22 production [Term] id: GO:0072621 name: interleukin-23 secretion namespace: biological_process def: "The regulated release of interleukin-23 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-23 secretion" EXACT [GOC:BHF] synonym: "IL23 secretion" EXACT [GOC:BHF] synonym: "interleukin-23 complex secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032627 ! interleukin-23 production [Term] id: GO:0072622 name: interleukin-24 secretion namespace: biological_process def: "The regulated release of interleukin-24 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-24 secretion" EXACT [GOC:BHF] synonym: "IL24 secretion" EXACT [GOC:BHF] synonym: "MDA7 secretion" EXACT [GOC:BHF] synonym: "ST16 secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032628 ! interleukin-24 production [Term] id: GO:0072623 name: interleukin-25 secretion namespace: biological_process def: "The regulated release of interleukin-25 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-25 secretion" EXACT [GOC:BHF] synonym: "IL17E secretion" EXACT [GOC:BHF] synonym: "IL25 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032629 ! interleukin-25 production [Term] id: GO:0072624 name: interleukin-26 secretion namespace: biological_process def: "The regulated release of interleukin-26 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "AK155 secretion" NARROW [GOC:BHF] synonym: "IL-26 secretion" EXACT [GOC:BHF] synonym: "IL26 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032630 ! interleukin-26 production [Term] id: GO:0072625 name: interleukin-27 secretion namespace: biological_process def: "The regulated release of interleukin-27 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-27 secretion" EXACT [GOC:BHF] synonym: "IL27 secretion" EXACT [GOC:BHF] synonym: "interleukin-27 complex secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032631 ! interleukin-27 production [Term] id: GO:0072626 name: interleukin-35 secretion namespace: biological_process def: "The regulated release of interleukin-35 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-35 secretion" EXACT [GOC:BHF] synonym: "IL35 secretion" EXACT [GOC:BHF] synonym: "interleukin-35 complex secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0070753 ! interleukin-35 production [Term] id: GO:0072627 name: interleukin-28A production namespace: biological_process def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-28A production" EXACT [GOC:BHF] synonym: "IL28A production" EXACT [GOC:BHF] synonym: "interferon lambda 2 production" EXACT [GOC:BHF] is_a: GO:0034343 ! type III interferon production [Term] id: GO:0072628 name: interleukin-28A secretion namespace: biological_process def: "The regulated release of interleukin-28A from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-28A secretion" EXACT [GOC:BHF] synonym: "IL28A secretion" EXACT [GOC:BHF] synonym: "interferon lambda 2 secretion" EXACT [GOC:BHF] is_a: GO:0072644 ! type III interferon secretion relationship: part_of GO:0072627 ! interleukin-28A production [Term] id: GO:0072629 name: interleukin-28B production namespace: biological_process def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-28B production" EXACT [GOC:BHF] synonym: "IL28B production" EXACT [GOC:BHF] synonym: "interferon lambda 3 production" EXACT [GOC:BHF] is_a: GO:0034343 ! type III interferon production [Term] id: GO:0072630 name: interleukin-28B secretion namespace: biological_process def: "The regulated release of interleukin-28B from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-28B secretion" EXACT [GOC:BHF] synonym: "IL28B secretion" EXACT [GOC:BHF] synonym: "interferon lambda 3 secretion" EXACT [GOC:BHF] is_a: GO:0072644 ! type III interferon secretion relationship: part_of GO:0072629 ! interleukin-28B production [Term] id: GO:0072631 name: interleukin-29 production namespace: biological_process def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-29 production" EXACT [GOC:BHF] synonym: "IL29 production" EXACT [GOC:BHF] synonym: "interferon lambda 1 production" EXACT [GOC:BHF] is_a: GO:0034343 ! type III interferon production [Term] id: GO:0072632 name: interleukin-29 secretion namespace: biological_process def: "The regulated release of interleukin-29 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-29 secretion" EXACT [GOC:BHF] synonym: "IL29 secretion" EXACT [GOC:BHF] synonym: "interferon lambda 1 secretion" EXACT [GOC:BHF] is_a: GO:0072644 ! type III interferon secretion relationship: part_of GO:0072631 ! interleukin-29 production [Term] id: GO:0072633 name: interleukin-30 production namespace: biological_process def: "The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-30 production" EXACT [GOC:BHF] synonym: "interleukin-30 complex production" EXACT [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0072634 name: interleukin-30 secretion namespace: biological_process def: "The regulated release of interleukin-30 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-30 secretion" EXACT [GOC:BHF] synonym: "interleukin-30 complex secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0072633 ! interleukin-30 production [Term] id: GO:0072635 name: interleukin-31 production namespace: biological_process def: "The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-31 production" EXACT [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0072636 name: interleukin-31 secretion namespace: biological_process def: "The regulated release of interleukin-31 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-31 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0072635 ! interleukin-31 production [Term] id: GO:0072637 name: interleukin-32 production namespace: biological_process def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-32 production" EXACT [GOC:BHF] synonym: "IL32 production" EXACT [GOC:BHF] synonym: "NK4 production" NARROW [GOC:BHF] synonym: "TAIF production" NARROW [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0072638 name: interleukin-32 secretion namespace: biological_process def: "The regulated release of interleukin-32 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-32 secretion" EXACT [GOC:BHF] synonym: "IL32 secretion" EXACT [GOC:BHF] synonym: "NK4 secretion" NARROW [GOC:BHF] synonym: "TAIF secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0072637 ! interleukin-32 production [Term] id: GO:0072639 name: interleukin-33 production namespace: biological_process def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "C9orf26 production" NARROW [GOC:BHF] synonym: "IL-33 production" EXACT [GOC:BHF] synonym: "IL1F11 production" NARROW [GOC:BHF] synonym: "IL33 production" EXACT [GOC:BHF] synonym: "NF-HEV production" EXACT [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0072640 name: interleukin-33 secretion namespace: biological_process def: "The regulated release of interleukin-33 from a cell or group of cells." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "C9orf26 secretion" NARROW [GOC:BHF] synonym: "IL-33 secretion" EXACT [GOC:BHF] synonym: "IL1F11 secretion" NARROW [GOC:BHF] synonym: "IL33 secretion" EXACT [GOC:BHF] synonym: "NF-HEV secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0072639 ! interleukin-33 production [Term] id: GO:0072641 name: type I interferon secretion namespace: biological_process def: "The regulated release of type I interferon from a cell or group of cells." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "type I IFN secretion" EXACT [GOC:mah] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032606 ! type I interferon production [Term] id: GO:0072642 name: interferon-alpha secretion namespace: biological_process def: "The regulated release of interferon-alpha from a cell or group of cells." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-alpha secretion" EXACT [GOC:mah] synonym: "IFNA secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0032607 ! interferon-alpha production [Term] id: GO:0072643 name: interferon-gamma secretion namespace: biological_process def: "The regulated release of interferon-gamma from a cell or group of cells." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-gamma secretion" EXACT [GOC:mah] synonym: "IFNG secretion" EXACT [GOC:BHF] synonym: "type II IFN secretion" EXACT [GOC:mah] synonym: "type II interferon secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032609 ! interferon-gamma production [Term] id: GO:0072644 name: type III interferon secretion namespace: biological_process def: "The regulated release of type III interferon from a cell or group of cells." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "type III IFN secretion" EXACT [GOC:mah] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0034343 ! type III interferon production [Term] id: GO:0072645 name: interferon-delta production namespace: biological_process def: "The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-delta production" EXACT [GOC:mah] synonym: "IFND production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072646 name: interferon-delta secretion namespace: biological_process def: "The regulated release of interferon-delta from a cell or group of cells." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-delta secretion" EXACT [GOC:mah] synonym: "IFND secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072645 ! interferon-delta production [Term] id: GO:0072647 name: interferon-epsilon production namespace: biological_process def: "The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-epsilon production" EXACT [GOC:mah] synonym: "IFNE production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072648 name: interferon-epsilon secretion namespace: biological_process def: "The regulated release of interferon-epsilon from a cell or group of cells." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-epsilon secretion" EXACT [GOC:mah] synonym: "IFNE secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072647 ! interferon-epsilon production [Term] id: GO:0072649 name: interferon-kappa production namespace: biological_process def: "The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-kappa production" EXACT [GOC:mah] synonym: "IFNK production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072650 name: interferon-kappa secretion namespace: biological_process def: "The regulated release of interferon-kappa from a cell or group of cells." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-kappa secretion" EXACT [GOC:mah] synonym: "IFNK secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072649 ! interferon-kappa production [Term] id: GO:0072651 name: interferon-tau production namespace: biological_process def: "The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-tau production" EXACT [GOC:mah] synonym: "IFNT production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072652 name: interferon-tau secretion namespace: biological_process def: "The regulated release of interferon-tau from a cell or group of cells." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-tau secretion" EXACT [GOC:mah] synonym: "IFNT secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072651 ! interferon-tau production [Term] id: GO:0072653 name: interferon-omega production namespace: biological_process def: "The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-omega production" EXACT [GOC:mah] synonym: "IFNW production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072654 name: interferon-omega secretion namespace: biological_process def: "The regulated release of interferon-omega from a cell or group of cells." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-omega secretion" EXACT [GOC:mah] synonym: "IFNW secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072653 ! interferon-omega production [Term] id: GO:0072655 name: establishment of protein localization in mitochondrion namespace: biological_process def: "The directed movement of a protein to a specific location in the mitochondrion." [GOC:mah] synonym: "establishment of protein localisation to mitochondrion" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0070585 ! protein localization in mitochondrion [Term] id: GO:0072656 name: maintenance of protein location in mitochondrion namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0070585 ! protein localization in mitochondrion is_a: GO:0072595 ! maintenance of protein localization to organelle [Term] id: GO:0072657 name: protein localization in membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah] synonym: "protein localisation in membrane" EXACT [GOC:mah] is_a: GO:0016044 ! cellular membrane organization is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0072658 name: maintenance of protein location in membrane namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0032507 ! maintenance of protein location in cell relationship: part_of GO:0072657 ! protein localization in membrane [Term] id: GO:0072659 name: protein localization in plasma membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] synonym: "protein localisation in plasma membrane" EXACT [GOC:mah] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0072657 ! protein localization in membrane [Term] id: GO:0072660 name: maintenance of protein location in plasma membrane namespace: biological_process def: "Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072658 ! maintenance of protein location in membrane relationship: part_of GO:0072659 ! protein localization in plasma membrane [Term] id: GO:0072661 name: protein targeting to plasma membrane namespace: biological_process def: "The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein." [GOC:mah] synonym: "protein-plasma membrane targeting" EXACT [GOC:mah] is_a: GO:0006605 ! protein targeting is_a: GO:0090002 ! establishment of protein localization in plasma membrane [Term] id: GO:0072662 name: protein localization to peroxisome namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a peroxisome." [GOC:ecd] synonym: "protein localisation to peroxisome" EXACT [GOC:mah] is_a: GO:0007031 ! peroxisome organization is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0072663 name: establishment of protein localization to peroxisome namespace: biological_process def: "The directed movement of a protein to a specific location in a peroxisome." [GOC:mah] synonym: "establishment of protein localisation to peroxisome" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0072662 ! protein localization to peroxisome [Term] id: GO:0072664 name: maintenance of protein location in peroxisome namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a peroxisome, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization to organelle relationship: part_of GO:0072662 ! protein localization to peroxisome [Term] id: GO:0072665 name: protein localization to vacuole namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd] synonym: "protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0007033 ! vacuole organization is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0072666 name: establishment of protein localization to vacuole namespace: biological_process def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah] synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0072665 ! protein localization to vacuole [Term] id: GO:0072667 name: maintenance of protein location in vacuole namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization to organelle relationship: part_of GO:0072665 ! protein localization to vacuole [Term] id: GO:0072668 name: tubulin complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a tubulin complex. Includes the synthesis and folding of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex. A tubulin complex is a heterodimer of tubulins alpha and beta, from which microtubules are assembled." [GOC:mah] is_a: GO:0070271 ! protein complex biogenesis [Term] id: GO:0072669 name: tRNA-splicing ligase complex namespace: cellular_component def: "A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021] synonym: "tRNA splicing ligase complex" EXACT [GOC:mah] xref: MetaCyc:ENTMULTI-CPLX is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0072670 name: mitochondrial tRNA threonylcarbamoyladenosine modification namespace: biological_process def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GOC:mcc, PMID:21183954] synonym: "mitochondrial tRNA t6A modification" EXACT [GOC:mcc] is_a: GO:0070900 ! mitochondrial tRNA modification [Term] id: GO:0072671 name: mitochondria-associated protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions." [GOC:mcc, PMID:21070972, PMID:21109188] synonym: "MAD" EXACT [GOC:mcc] synonym: "mitochondria-associated protein degradation" EXACT [GOC:mcc] synonym: "mitochondrion-associated protein catabolic process" EXACT [GOC:mah] is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0072672 name: neutrophil extravasation namespace: biological_process def: "The migration of a neutrophil from the blood vessels into the surrounding tissue." [CL:0000775, GOC:BHF] is_a: GO:0045123 ! cellular extravasation [Term] id: GO:0072673 name: lamellipodium morphogenesis namespace: biological_process def: "A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized." [GOC:BHF, GOC:mah] synonym: "lamellipodium organization" RELATED [GOC:mah] is_a: GO:0048858 ! cell projection morphogenesis [Term] id: GO:0072674 name: multinuclear osteoclast differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000779, GOC:mah, PMID:12713016] synonym: "multinuclear osteoclast formation" RELATED [GOC:BHF, GOC:mah] synonym: "multinuclear osteoclast morphogenesis" RELATED [GOC:BHF, GOC:mah] is_a: GO:0030316 ! osteoclast differentiation [Term] id: GO:0072675 name: osteoclast fusion namespace: biological_process def: "The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast." [CL:0000092, CL:0000779, GOC:BHF, GOC:mah, PMID:12713016] is_a: GO:0000768 ! syncytium formation by plasma membrane fusion relationship: part_of GO:0072674 ! multinuclear osteoclast differentiation [Term] id: GO:0072676 name: lymphocyte migration namespace: biological_process def: "The movement of a lymphocyte within or between different tissues and organs of the body." [CL:0000542, GOC:BHF, GOC:mah] is_a: GO:0050900 ! leukocyte migration [Term] id: GO:0072677 name: eosinophil migration namespace: biological_process def: "The movement of an eosinophil within or between different tissues and organs of the body." [CL:0000771, GOC:BHF, GOC:mah] is_a: GO:0050900 ! leukocyte migration [Term] id: GO:0072678 name: T cell migration namespace: biological_process def: "The movement of a T cell within or between different tissues and organs of the body." [CL:0000084, GOC:BHF, GOC:mah] synonym: "T lymphocyte migration" EXACT [CL:0000084] synonym: "T-cell migration" EXACT [CL:0000084] synonym: "T-lymphocyte migration" EXACT [CL:0000084] is_a: GO:0072676 ! lymphocyte migration [Term] id: GO:0072679 name: thymocyte migration namespace: biological_process def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development." [CL:0000893, GOC:BHF, GOC:mah] synonym: "immature T cell migration" RELATED [CL:0000893] synonym: "immature T lymphocyte migration" RELATED [CL:0000893] synonym: "immature T-cell migration" RELATED [CL:0000893] synonym: "immature T-lymphocyte migration" RELATED [CL:0000893] synonym: "thymic lymphocyte migration" EXACT [CL:0000893] is_a: GO:0072678 ! T cell migration [Term] id: GO:0072680 name: extracellular matrix-dependent thymocyte migration namespace: biological_process def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on extracellular matrix components including fibronectin, collagen and laminin." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819] synonym: "extracellular matrix-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah] synonym: "extracellular matrix-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah] synonym: "extracellular matrix-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah] synonym: "extracellular matrix-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah] synonym: "extracellular matrix-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah] is_a: GO:0006929 ! substrate-dependent cell migration is_a: GO:0072679 ! thymocyte migration [Term] id: GO:0072681 name: fibronectin-dependent thymocyte migration namespace: biological_process def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819] synonym: "fibronectin-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah] synonym: "fibronectin-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah] synonym: "fibronectin-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah] synonym: "fibronectin-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah] synonym: "fibronectin-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah] is_a: GO:0072680 ! extracellular matrix-dependent thymocyte migration [Term] id: GO:0072682 name: eosinophil extravasation namespace: biological_process def: "The migration of an eosinophil from the blood vessels into the surrounding tissue." [CL:0000771, GOC:BHF, GOC:mah] is_a: GO:0045123 ! cellular extravasation is_a: GO:0072677 ! eosinophil migration [Term] id: GO:0072683 name: T cell extravasation namespace: biological_process def: "The migration of a T cell from the blood vessels into the surrounding tissue." [CL:0000084, GOC:BHF, GOC:mah] synonym: "T lymphocyte extravasation" EXACT [CL:0000084] synonym: "T-cell extravasation" EXACT [CL:0000084] synonym: "T-lymphocyte extravasation" EXACT [CL:0000084] is_a: GO:0045123 ! cellular extravasation is_a: GO:0072678 ! T cell migration [Term] id: GO:0072684 name: mitochondrial tRNA 3'-trailer cleavage, endonucleolytic namespace: biological_process def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion." [GOC:mah] synonym: "mitochondrial endonucleolytic tRNA 3'-end cleavage" EXACT [GOC:mah] synonym: "mitochondrial endonucleolytic tRNA 3'-trailer cleavage" RELATED [GOC:mah] synonym: "mitochondrial tRNA 3'-end cleavage, endonucleolytic" EXACT [GOC:mah] is_a: GO:0000965 ! mitochondrial RNA 3'-end processing is_a: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic [Term] id: GO:0072685 name: Mre11 complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an Mre11 complex, a trimeric protein complex that possesses endonuclease activity and is involved in meiotic recombination, DNA repair and checkpoint signaling." [GOC:mah, PMID:19211838] synonym: "MRN complex assembly" EXACT [GOC:mah] synonym: "MRX complex assembly" EXACT [GOC:mah] synonym: "Rad50 complex assembly" EXACT [GOC:mah] synonym: "RAD50-MRE11-NBN complex assembly" EXACT [CORUM:2767, GOC:mah] synonym: "Rad50-Rad32-Nbs1 complex assembly" EXACT [GOC:mah] synonym: "RMX complex assembly" EXACT [GOC:mah] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0075000 name: response to host osmotic environment namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "response of symbiont to host osmotic environment" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075001 name: adhesion of symbiont infection structure to host namespace: biological_process def: "The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. synonym: "adhesion of symbiont infection structure to host during symbiotic interaction" EXACT [] synonym: "attachment of symbiont infection structure to host" EXACT [] is_a: GO:0044406 ! adhesion to host [Term] id: GO:0075002 name: adhesion of symbiont germination tube to host namespace: biological_process def: "The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont germination tube to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075003 name: adhesion of symbiont appressorium to host namespace: biological_process def: "The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont appressorium to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075004 name: adhesion of symbiont spore to host namespace: biological_process def: "The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont spore to host during symbiotic interaction" EXACT [] is_a: GO:0044406 ! adhesion to host [Term] id: GO:0075005 name: spore germination on or near host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0009847 ! spore germination is_a: GO:0044132 ! development of symbiont on or near host is_a: GO:0051701 ! interaction with host [Term] id: GO:0075006 name: modulation of spore germination on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044138 ! modulation of development of symbiont on or near host relationship: regulates GO:0075005 ! spore germination on or near host [Term] id: GO:0075007 name: positive regulation of spore germination on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075006 ! modulation of spore germination on or near host relationship: positively_regulates GO:0075005 ! spore germination on or near host [Term] id: GO:0075008 name: negative regulation of spore germination on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075006 ! modulation of spore germination on or near host relationship: negatively_regulates GO:0075005 ! spore germination on or near host [Term] id: GO:0075009 name: germ tube formation on or near host namespace: biological_process def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044132 ! development of symbiont on or near host relationship: part_of GO:0075005 ! spore germination on or near host [Term] id: GO:0075010 name: modulation of germ tube formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075006 ! modulation of spore germination on or near host relationship: regulates GO:0075009 ! germ tube formation on or near host [Term] id: GO:0075011 name: positive regulation of germ tube formation on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075007 ! positive regulation of spore germination on or near host is_a: GO:0075010 ! modulation of germ tube formation on or near host relationship: positively_regulates GO:0075009 ! germ tube formation on or near host [Term] id: GO:0075012 name: negative regulation of germ tube formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075008 ! negative regulation of spore germination on or near host is_a: GO:0075010 ! modulation of germ tube formation on or near host relationship: negatively_regulates GO:0075009 ! germ tube formation on or near host [Term] id: GO:0075013 name: growth or development of symbiont on or near host phyllosphere namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host phyllosphere ; GO:0044135' and 'development of symbiont on or near host phyllosphere ; GO:0044134'. is_obsolete: true replaced_by: GO:0044134 replaced_by: GO:0044135 [Term] id: GO:0075014 name: growth or development of symbiont on or near host rhizosphere namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host rhizosphere ; GO:0044137' and 'development of symbiont on or near host rhizosphere ; GO:0044136'. is_obsolete: true replaced_by: GO:0044136 replaced_by: GO:0044137 [Term] id: GO:0075015 name: formation of infection structure on or near host namespace: biological_process def: "The process in which a symbiont structure that serves to infect the host is formed on or near its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. synonym: "formation by symbiont of infection structure on or near host" EXACT [] is_a: GO:0044115 ! development of symbiont involved in interaction with host is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0075016 name: appressorium formation on or near host namespace: biological_process def: "The process in which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "appressorium formation for entry into host, on or near host" EXACT [] synonym: "formation of an appressorium by symbiont on or near host" EXACT [] is_a: GO:0044134 ! development of symbiont on or near host phyllosphere is_a: GO:0075015 ! formation of infection structure on or near host [Term] id: GO:0075017 name: regulation of appressorium formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044138 ! modulation of development of symbiont on or near host relationship: regulates GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075018 name: positive regulation of appressorium formation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075017 ! regulation of appressorium formation on or near host relationship: positively_regulates GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075019 name: negative regulation of appressorium formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075017 ! regulation of appressorium formation on or near host relationship: negatively_regulates GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075020 name: calcium or calmodulin-mediated activation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont calcium or calmodulin-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "Ca++ or calmodulin-mediated activation of appressorium formation" EXACT [] synonym: "Ca2+ or calmodulin-mediated activation of appressorium formation" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075021 name: cAMP-mediated activation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont cAMP mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "cyclic AMP mediated activation of appressorium formation" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075022 name: ethylene-mediated activation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075023 name: MAPK-mediated regulation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "mitogen-activated protein kinase-mediated activation of appressorium formation" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075024 name: phospholipase C-mediated activation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont phospholipase C-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075025 name: initiation of appressorium on or near host namespace: biological_process def: "The process in which a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "appressorium initiation on or near host" EXACT [] synonym: "initiation of appressorium by symbiont on or near host" EXACT [] synonym: "initiation of symbiont appressorium on or near host" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075026 name: regulation of appressorium initiation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "regulation of initiation of appressorium on or near host" EXACT [] is_a: GO:0075017 ! regulation of appressorium formation on or near host relationship: regulates GO:0075025 ! initiation of appressorium on or near host [Term] id: GO:0075027 name: positive regulation of appressorium initiation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "positive regulation of initiation of appressorium on or near host" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host is_a: GO:0075026 ! regulation of appressorium initiation on or near host relationship: positively_regulates GO:0075025 ! initiation of appressorium on or near host [Term] id: GO:0075028 name: negative regulation of appressorium initiation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium initiation near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "negative regulation of initiation of appressorium on or near host" EXACT [] is_a: GO:0075019 ! negative regulation of appressorium formation on or near host is_a: GO:0075026 ! regulation of appressorium initiation on or near host relationship: negatively_regulates GO:0075025 ! initiation of appressorium on or near host [Term] id: GO:0075029 name: formation of symbiont germ tube hook structure on or near host namespace: biological_process def: "The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "formation of germ tube tip of symbiont on or near the exterior of host" EXACT [] synonym: "symbiont germ tube hook structure formation on or near host" EXACT [] is_a: GO:0075015 ! formation of infection structure on or near host relationship: part_of GO:0075025 ! initiation of appressorium on or near host [Term] id: GO:0075030 name: modulation of symbiont germ tube hook structure formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "modulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] synonym: "regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] is_a: GO:0075026 ! regulation of appressorium initiation on or near host relationship: regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host [Term] id: GO:0075031 name: positive regulation of symbiont germ tube hook structure formation on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "positive regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] synonym: "positive regulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] is_a: GO:0075027 ! positive regulation of appressorium initiation on or near host is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host relationship: positively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host [Term] id: GO:0075032 name: negative regulation of symbiont germ tube hook structure formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "negative regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] synonym: "negative regulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] is_a: GO:0075028 ! negative regulation of appressorium initiation on or near host is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host relationship: negatively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host [Term] id: GO:0075033 name: septum formation involved in appressorium formation on or near host namespace: biological_process def: "The process in which a symbiont partition is formed to separate the appressorium from the germination tube, occurring on or near the exterior of its host organism during appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "septum formation during appressorium formation on or near host" RELATED [GOC:tb] is_a: GO:0044132 ! development of symbiont on or near host relationship: part_of GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075034 name: nuclear division involved in appressorium formation on or near host namespace: biological_process def: "The process in which nuclear division occurs within a symbiont spore that contributes to appressorium formation on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "nuclear division during appressorium formation on or near host" RELATED [GOC:dph] is_a: GO:0000280 ! nuclear division relationship: part_of GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075035 name: maturation of appressorium on or near host namespace: biological_process def: "The process in which specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "appressorium maturation on or near host" EXACT [] synonym: "maturation of symbiont appressorium on or near host" EXACT [] is_a: GO:0044115 ! development of symbiont involved in interaction with host relationship: part_of GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075036 name: regulation of appressorium maturation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "regulation of maturation of appressorium on or near host" EXACT [] is_a: GO:0075017 ! regulation of appressorium formation on or near host relationship: regulates GO:0075035 ! maturation of appressorium on or near host [Term] id: GO:0075037 name: positive regulation of appressorium maturation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "positive regulation maturation of appressorium on or near host" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host is_a: GO:0075036 ! regulation of appressorium maturation on or near host relationship: positively_regulates GO:0075035 ! maturation of appressorium on or near host [Term] id: GO:0075038 name: negative regulation of appressorium maturation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium maturation in, near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "negative regulation of maturation of appressorium on or near host" EXACT [] is_a: GO:0075019 ! negative regulation of appressorium formation on or near host is_a: GO:0075036 ! regulation of appressorium maturation on or near host relationship: negatively_regulates GO:0075035 ! maturation of appressorium on or near host [Term] id: GO:0075039 name: establishment of turgor in appressorium namespace: biological_process def: "The process in which hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "establishment of turgor in symbiont appressorium on or near host" EXACT [] synonym: "formation of turgor in appressorium" EXACT [] synonym: "generation of turgor in appressorium" EXACT [] is_a: GO:0044115 ! development of symbiont involved in interaction with host relationship: part_of GO:0075035 ! maturation of appressorium on or near host [Term] id: GO:0075040 name: regulation of establishment of turgor in appressorium namespace: biological_process def: "Any process modulates the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "regulation of turgor formation in appressorium" RELATED [] is_a: GO:0075036 ! regulation of appressorium maturation on or near host relationship: regulates GO:0075039 ! establishment of turgor in appressorium [Term] id: GO:0075041 name: positive regulation of establishment of turgor in appressorium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075018 ! positive regulation of appressorium formation on or near host is_a: GO:0075040 ! regulation of establishment of turgor in appressorium relationship: positively_regulates GO:0075039 ! establishment of turgor in appressorium [Term] id: GO:0075042 name: negative regulation of establishment of turgor in appressorium namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075038 ! negative regulation of appressorium maturation on or near host is_a: GO:0075040 ! regulation of establishment of turgor in appressorium relationship: negatively_regulates GO:0075039 ! establishment of turgor in appressorium [Term] id: GO:0075043 name: maintenance of turgor in appressorium by melanization namespace: biological_process def: "The process in which melanin is produced in the appressorium of the symbiont on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "melanization of appressorium to maintain turgor pressure" EXACT [] is_a: GO:0042438 ! melanin biosynthetic process is_a: GO:0075040 ! regulation of establishment of turgor in appressorium [Term] id: GO:0075044 name: autophagy of host cells involved in interaction with symbiont namespace: biological_process def: "The process in which the host cells digest parts of their own cytoplasm during interaction with its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should be used to annotate gene products of host. synonym: "autophagy of host cells during interaction with symbiont" RELATED [GOC:dph] is_a: GO:0075071 ! autophagy involved in symbiotic interaction [Term] id: GO:0075045 name: regulation of formation by symbiont of haustorium for nutrient acquisition from host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044127 ! regulation of development of symbiont in host is_a: GO:0060259 ! regulation of feeding behavior relationship: regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host [Term] id: GO:0075046 name: positive regulation of formation by symbiont of haustorium for nutrient acquisition from host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044129 ! positive regulation of development of symbiont in host is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host relationship: positively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host [Term] id: GO:0075047 name: negative regulation of formation by symbiont of haustorium for nutrient acquisition from host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044131 ! negative regulation of development of symbiont in host is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host relationship: negatively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host [Term] id: GO:0075048 name: cell wall strengthening in symbiont involved in entry into host namespace: biological_process def: "A process in which the cell wall of the symbiont is strengthened or thickened during penetration into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "cell wall strengthening in symbiont during entry into host" RELATED [GOC:tb] synonym: "cell wall thickening in symbiont during entry into host" RELATED [] synonym: "symbiont cell wall strengthening during entry into host" RELATED [] is_a: GO:0052386 ! cell wall thickening relationship: part_of GO:0044409 ! entry into host [Term] id: GO:0075049 name: modulation of symbiont cell wall strengthening involved in entry into host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "modulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0052372 ! modulation by symbiont of entry into host relationship: regulates GO:0075048 ! cell wall strengthening in symbiont involved in entry into host [Term] id: GO:0075050 name: positive regulation of symbiont cell wall strengthening involved in entry into host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "positive regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0075049 ! modulation of symbiont cell wall strengthening involved in entry into host is_a: GO:0075294 ! positive regulation by symbiont of entry into host relationship: positively_regulates GO:0075048 ! cell wall strengthening in symbiont involved in entry into host [Term] id: GO:0075051 name: negative regulation of symbiont cell wall strengthening involved in entry into host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "negative regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0052374 ! negative regulation by symbiont of entry into host is_a: GO:0075049 ! modulation of symbiont cell wall strengthening involved in entry into host relationship: negatively_regulates GO:0075048 ! cell wall strengthening in symbiont involved in entry into host [Term] id: GO:0075052 name: entry into host via a specialized structure namespace: biological_process def: "Penetration via a specialized structure of symbiont into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "entry into host via a specialized structure during symbiotic interaction" EXACT [] is_a: GO:0044409 ! entry into host [Term] id: GO:0075053 name: formation of symbiont penetration peg for entry into host namespace: biological_process def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "symbiont penetration peg formation for entry into host" EXACT [] is_a: GO:0075015 ! formation of infection structure on or near host relationship: part_of GO:0075052 ! entry into host via a specialized structure [Term] id: GO:0075054 name: modulation of symbiont penetration peg formation for entry into host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0052372 ! modulation by symbiont of entry into host relationship: regulates GO:0075053 ! formation of symbiont penetration peg for entry into host [Term] id: GO:0075055 name: positive regulation of symbiont penetration peg formation for entry into host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host is_a: GO:0075294 ! positive regulation by symbiont of entry into host relationship: positively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host [Term] id: GO:0075056 name: negative regulation of symbiont penetration peg formation for entry into host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0052374 ! negative regulation by symbiont of entry into host is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host relationship: negatively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host [Term] id: GO:0075057 name: initiation of symbiont penetration peg namespace: biological_process def: "The process in which a relatively unspecialized cell of the symbiont starts to acquire the characteristics of a mature penetration peg to penetrate into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "symbiont penetration peg initiation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0075053 ! formation of symbiont penetration peg for entry into host [Term] id: GO:0075058 name: modulation of symbiont penetration peg initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of penetration peg initiation, the process in which a relatively unspecialized cell start to acquire the characteristics of a mature penetration peg when the symbiont penetrates its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host relationship: regulates GO:0075057 ! initiation of symbiont penetration peg [Term] id: GO:0075059 name: positive regulation of symbiont penetration peg initiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg initiation, the process in which a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075055 ! positive regulation of symbiont penetration peg formation for entry into host is_a: GO:0075058 ! modulation of symbiont penetration peg initiation relationship: positively_regulates GO:0075057 ! initiation of symbiont penetration peg [Term] id: GO:0075060 name: negative regulation of symbiont penetration peg initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration peg initiation, the process in which a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075056 ! negative regulation of symbiont penetration peg formation for entry into host is_a: GO:0075058 ! modulation of symbiont penetration peg initiation relationship: negatively_regulates GO:0075057 ! initiation of symbiont penetration peg [Term] id: GO:0075061 name: formation of symbiont invasive hypha in host namespace: biological_process def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of invasive growth within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "formation of symbiont invasive hypha within host" EXACT [] synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT [] synonym: "symbiont invasive hypha formation within host" EXACT [] is_a: GO:0044114 ! development of symbiont in host [Term] id: GO:0075062 name: regulation of symbiont invasive hypha formation in host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "regulation of symbiont invasive hypha formation within host" EXACT [] is_a: GO:0044127 ! regulation of development of symbiont in host relationship: regulates GO:0075061 ! formation of symbiont invasive hypha in host [Term] id: GO:0075063 name: positive regulation of symbiont invasive hypha formation in host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "positive regulation of symbiont invasive hypha formation within host" EXACT [] is_a: GO:0044129 ! positive regulation of development of symbiont in host is_a: GO:0075062 ! regulation of symbiont invasive hypha formation in host relationship: positively_regulates GO:0075061 ! formation of symbiont invasive hypha in host [Term] id: GO:0075064 name: negative regulation of symbiont invasive hypha formation in host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "negative regulation of symbiont invasive hypha formation within host" EXACT [] is_a: GO:0044131 ! negative regulation of development of symbiont in host is_a: GO:0075062 ! regulation of symbiont invasive hypha formation in host relationship: negatively_regulates GO:0075061 ! formation of symbiont invasive hypha in host [Term] id: GO:0075065 name: growth or development of symbiont in host cell namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host cell ; GO:0044118' and 'growth of symbiont in host cell ; GO:0044119'. is_obsolete: true replaced_by: GO:0044118 replaced_by: GO:0044119 [Term] id: GO:0075066 name: growth or development of symbiont in host organelle namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host organelle ; GO:0044120' and 'growth of symbiont in host organelle ; GO:0044121'. is_obsolete: true replaced_by: GO:0044120 replaced_by: GO:0044121 [Term] id: GO:0075067 name: growth or development of symbiont in host intercellular space namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development during symbiotic interaction ; GO:0044111' and 'growth of symbiont in host intercellular space ; GO:0044125'. is_obsolete: true replaced_by: GO:0044124 replaced_by: GO:0044125 [Term] id: GO:0075068 name: growth or development of symbiont in host vascular tissue namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host vascular tissue ; GO:0044122' and 'growth of symbiont in host vascular tissue ; GO:0044123'. is_obsolete: true replaced_by: GO:0044122 replaced_by: GO:0044123 [Term] id: GO:0075069 name: adhesion of symbiont infection cushion to host namespace: biological_process def: "The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont infection cushion to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075070 name: adhesion of symbiont hyphopodium to host namespace: biological_process def: "The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont hyphopodium to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075071 name: autophagy involved in symbiotic interaction namespace: biological_process def: "The process in which cells digest parts of their own cytoplasm during a symbiotic interaction; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should be used to annotate gene products of the organism involved in this process. synonym: "autophagy during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0006914 ! autophagy relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0075072 name: autophagy of symbiont cells involved in interaction with host namespace: biological_process def: "The process in which symbiont cells digest parts of their own cytoplasm during interaction with its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should be used to annotate gene products of symbiont. synonym: "autophagy of symbiont cells during interaction with host" RELATED [GOC:dph] is_a: GO:0075071 ! autophagy involved in symbiotic interaction relationship: part_of GO:0051701 ! interaction with host [Term] id: GO:0075073 name: autophagy of symbiont cells on or near host surface namespace: biological_process def: "The process in which symbiont cells digest parts of their own cytoplasm, occurring when the symbiont is on or near its host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should be used to annotate gene products of symbiont. is_a: GO:0075072 ! autophagy of symbiont cells involved in interaction with host [Term] id: GO:0075074 name: spore autophagy involved in appressorium formation on or near host namespace: biological_process def: "The process in which a symbiont spore digests parts of its own cytoplasm, occurring when the appressorium forms on or near the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "autophagy of spores during appressorium formation on or near host" EXACT [] synonym: "spore autophagy during appressorium formation on or near host" RELATED [GOC:tb] is_a: GO:0075073 ! autophagy of symbiont cells on or near host surface relationship: part_of GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075075 name: modulation by host of symbiont adenylate cyclase activity namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host adenylate cyclase activity ; GO:0075106". is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0052422 ! modulation by host of symbiont catalytic activity [Term] id: GO:0075076 name: positive regulation by host of symbiont adenylate cyclase activity namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase activity ; GO:0075107". is_a: GO:0043947 ! positive regulation by host of symbiont catalytic activity is_a: GO:0045762 ! positive regulation of adenylate cyclase activity is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity [Term] id: GO:0075077 name: negative regulation by host of symbiont adenylate cyclase activity namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host adenylate cyclase activity ; GO:0075108". is_a: GO:0007194 ! negative regulation of adenylate cyclase activity is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity [Term] id: GO:0075078 name: modulation by host of symbiont receptor-mediated signal transduction namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host receptor-mediated signal transduction ; GO:0075109". is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway [Term] id: GO:0075079 name: positive regulation by host of symbiont receptor-mediated signal transduction namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host receptor-mediated signal transduction ; GO:0075110". is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction [Term] id: GO:0075080 name: negative regulation by host of symbiont receptor-mediated signal transduction namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host receptor-mediated signal transduction ; GO:0075111". is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction [Term] id: GO:0075081 name: modulation by host of symbiont transmembrane receptor-mediated signal transduction namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075112". is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction [Term] id: GO:0075082 name: positive regulation by host of symbiont transmembrane receptor-mediated signal transduction namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075113". is_a: GO:0075079 ! positive regulation by host of symbiont receptor-mediated signal transduction is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction [Term] id: GO:0075083 name: negative regulation by host of symbiont transmembrane receptor-mediated signal transduction namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075114". is_a: GO:0075080 ! negative regulation by host of symbiont receptor-mediated signal transduction is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction [Term] id: GO:0075084 name: modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075115". synonym: "modulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction [Term] id: GO:0075085 name: positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075116". synonym: "activation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] synonym: "promotion by host of symbiont transmembrane receptor protein activity involved in cAMP-mediated signal transduction" EXACT [] synonym: "stimulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "upregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT [] is_a: GO:0075082 ! positive regulation by host of symbiont transmembrane receptor-mediated signal transduction is_a: GO:0075084 ! modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction is_a: GO:0075206 ! positive regulation by host of symbiont cAMP-mediated signal transduction [Term] id: GO:0075086 name: negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075117". synonym: "downregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT [] synonym: "inhibition by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] is_a: GO:0075083 ! negative regulation by host of symbiont transmembrane receptor-mediated signal transduction is_a: GO:0075084 ! modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction is_a: GO:0075207 ! negative regulation by host of symbiont cAMP-mediated signal transduction [Term] id: GO:0075087 name: modulation by host of symbiont G-protein coupled receptor protein signal transduction namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075118". is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction [Term] id: GO:0075088 name: positive regulation by host of symbiont G-protein coupled receptor protein signal transduction namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075119". is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0075082 ! positive regulation by host of symbiont transmembrane receptor-mediated signal transduction is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction [Term] id: GO:0075089 name: negative regulation by host of symbiont G-protein coupled receptor protein signal transduction namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075120". is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0075083 ! negative regulation by host of symbiont transmembrane receptor-mediated signal transduction is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction [Term] id: GO:0075090 name: modulation by host of symbiont signal transduction mediated by G-protein alpha subunit namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075121". is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction [Term] id: GO:0075091 name: positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075122". is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction is_a: GO:0075090 ! modulation by host of symbiont signal transduction mediated by G-protein alpha subunit [Term] id: GO:0075092 name: negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075123". is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction is_a: GO:0075090 ! modulation by host of symbiont signal transduction mediated by G-protein alpha subunit [Term] id: GO:0075093 name: modulation by host of symbiont signal transduction mediated by G-protein beta subunit namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075124". is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction [Term] id: GO:0075094 name: positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075125". is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction is_a: GO:0075093 ! modulation by host of symbiont signal transduction mediated by G-protein beta subunit [Term] id: GO:0075095 name: negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075126". is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction is_a: GO:0075093 ! modulation by host of symbiont signal transduction mediated by G-protein beta subunit [Term] id: GO:0075096 name: modulation by host of symbiont signal transduction mediated by G-protein gamma subunit namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075127". is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction [Term] id: GO:0075097 name: positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075128". is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction is_a: GO:0075096 ! modulation by host of symbiont signal transduction mediated by G-protein gamma subunit [Term] id: GO:0075098 name: negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075129". is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction is_a: GO:0075096 ! modulation by host of symbiont signal transduction mediated by G-protein gamma subunit [Term] id: GO:0075099 name: modulation by host of symbiont protein kinase-mediated signal transduction namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075130". is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway [Term] id: GO:0075100 name: positive regulation by host of symbiont protein kinase-mediated signal transduction namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075131". is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction [Term] id: GO:0075101 name: negative regulation by host of symbiont protein kinase-mediated signal transduction namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075132". is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction [Term] id: GO:0075102 name: negative regulation by host of symbiont MAP kinase-mediated signal transduction namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont MAP kinase-mediated signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host MAP kinase-mediated signal transduction pathway ; GO:0052078". is_a: GO:0052435 ! modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway is_a: GO:0075101 ! negative regulation by host of symbiont protein kinase-mediated signal transduction [Term] id: GO:0075103 name: modulation by host of symbiont calcium or calmodulin-mediated signal transduction namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075133". synonym: "modulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway [Term] id: GO:0075104 name: positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075134". synonym: "positive regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway is_a: GO:0075103 ! modulation by host of symbiont calcium or calmodulin-mediated signal transduction [Term] id: GO:0075105 name: negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075135". synonym: "negative regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway is_a: GO:0075103 ! modulation by host of symbiont calcium or calmodulin-mediated signal transduction [Term] id: GO:0075106 name: modulation by symbiont of host adenylate cyclase activity namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont adenylate cyclase activity ; GO:0075075". synonym: "Modulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] synonym: "Modulation by symbiont of host adenyl cyclase activity" EXACT [] synonym: "Modulation by symbiont of host adenylyl cyclase activity" EXACT [] synonym: "Modulation by symbiont of host adenylylcyclase activity" EXACT [] synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] synonym: "Modulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] synonym: "Modulation by symbiont of host cAMP generating peptide activity" RELATED [] is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0052148 ! modulation by symbiont of host catalytic activity [Term] id: GO:0075107 name: positive regulation by symbiont of host adenylate cyclase activity namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont adenylate cyclase activity ; GO:0075076". synonym: "Positive regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] synonym: "Positive regulation by symbiont of host adenyl cyclase activity" EXACT [] synonym: "Positive regulation by symbiont of host adenylyl cyclase activity" EXACT [] synonym: "Positive regulation by symbiont of host adenylylcyclase activity" EXACT [] synonym: "Positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] synonym: "Positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] synonym: "Positive regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] synonym: "Positive regulation by symbiont of host cAMP generating peptide activity" RELATED [] is_a: GO:0043948 ! positive regulation by symbiont of host catalytic activity is_a: GO:0045762 ! positive regulation of adenylate cyclase activity is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity [Term] id: GO:0075108 name: negative regulation by symbiont of host adenylate cyclase activity namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont adenylate cyclase activity ; GO:0075077". synonym: "Negative regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] synonym: "Negative regulation by symbiont of host adenyl cyclase activity" EXACT [] synonym: "Negative regulation by symbiont of host adenylyl cyclase activity" EXACT [] synonym: "Negative regulation by symbiont of host adenylylcyclase activity" EXACT [] synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] synonym: "Negative regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] synonym: "Negative regulation by symbiont of host cAMP generating peptide activity" RELATED [] is_a: GO:0007194 ! negative regulation of adenylate cyclase activity is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity [Term] id: GO:0075109 name: modulation by symbiont of host receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont receptor-mediated signal transduction ; GO:0075078". is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0075110 name: positive regulation by symbiont of host receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont receptor-mediated signal transduction ; GO:0075079". is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction [Term] id: GO:0075111 name: negative regulation by symbiont of host receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont receptor-mediated signal transduction ; GO:0075080". is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction [Term] id: GO:0075112 name: modulation by symbiont of host transmembrane receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075081". is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction [Term] id: GO:0075113 name: positive regulation by symbiont of host transmembrane receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075082". is_a: GO:0075110 ! positive regulation by symbiont of host receptor-mediated signal transduction is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction [Term] id: GO:0075114 name: negative regulation by symbiont of host transmembrane receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075083". is_a: GO:0075111 ! negative regulation by symbiont of host receptor-mediated signal transduction is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction [Term] id: GO:0075115 name: modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075084". synonym: "modulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction [Term] id: GO:0075116 name: positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075085". synonym: "activation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] synonym: "promotion by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] synonym: "stimulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "upregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] is_a: GO:0075113 ! positive regulation by symbiont of host transmembrane receptor-mediated signal transduction is_a: GO:0075115 ! modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction is_a: GO:0075209 ! positive regulation by symbiont of host cAMP-mediated signal transduction [Term] id: GO:0075117 name: negative regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075086". synonym: "downregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] synonym: "inhibition by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction is_a: GO:0075115 ! modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction is_a: GO:0075210 ! negative regulation by symbiont of host cAMP-mediated signal transduction [Term] id: GO:0075118 name: modulation by symbiont of host G-protein coupled receptor protein signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont G-protein coupled receptor protein signal transduction ; GO:0075087". is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction [Term] id: GO:0075119 name: positive regulation by symbiont of host G-protein coupled receptor protein signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075088". is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0075113 ! positive regulation by symbiont of host transmembrane receptor-mediated signal transduction is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction [Term] id: GO:0075120 name: negative regulation by symbiont of host G-protein coupled receptor protein signal transduction namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont G-protein coupled receptor protein signal transduction ; GO:0075089". is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction [Term] id: GO:0075121 name: modulation by symbiont of host signal transduction mediated by G-protein alpha subunit namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075090". is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction [Term] id: GO:0075122 name: positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075091". is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction is_a: GO:0075121 ! modulation by symbiont of host signal transduction mediated by G-protein alpha subunit [Term] id: GO:0075123 name: negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075092". is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction is_a: GO:0075121 ! modulation by symbiont of host signal transduction mediated by G-protein alpha subunit [Term] id: GO:0075124 name: modulation by symbiont of host signal transduction mediated by G-protein beta subunit namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075093". is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction [Term] id: GO:0075125 name: positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075094". is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction is_a: GO:0075124 ! modulation by symbiont of host signal transduction mediated by G-protein beta subunit [Term] id: GO:0075126 name: negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075095". is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction is_a: GO:0075124 ! modulation by symbiont of host signal transduction mediated by G-protein beta subunit [Term] id: GO:0075127 name: modulation by symbiont of host signal transduction mediated by G-protein gamma subunit namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075096". is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction [Term] id: GO:0075128 name: positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075097". is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction is_a: GO:0075127 ! modulation by symbiont of host signal transduction mediated by G-protein gamma subunit [Term] id: GO:0075129 name: negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075098". is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction is_a: GO:0075127 ! modulation by symbiont of host signal transduction mediated by G-protein gamma subunit [Term] id: GO:0075130 name: modulation by symbiont of host protein kinase-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075099". is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0075131 name: positive regulation by symbiont of host protein kinase-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075100". is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0075132 name: negative regulation by symbiont of host protein kinase-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075101". is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0075133 name: modulation by symbiont of host calcium or calmodulin-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075103". synonym: "modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0075134 name: positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075104". synonym: "positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction [Term] id: GO:0075135 name: negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075105". synonym: "negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction [Term] id: GO:0075136 name: response to host namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. subset: gosubset_prok synonym: "response of symbiont to host" RELATED [] is_a: GO:0051701 ! interaction with host is_a: GO:0051707 ! response to other organism [Term] id: GO:0075137 name: response to host redox environment namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "response of symbiont to host redox environment" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075138 name: response to host oxygen tension environment namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "response of symbiont to host oxygen tension environment" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075139 name: response to host iron concentration namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "response of symbiont to host iron concentration" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075140 name: response to host defense molecules namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting host defense molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "response of symbiont to host defense molecules" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075141 name: maintenance of symbiont tolerance to host environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075136 ! response to host [Term] id: GO:0075142 name: maintenance of symbiont tolerance to host oxygen tension environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against oxygen tension environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075138 ! response to host oxygen tension environment is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075143 name: maintenance of symbiont tolerance to host redox environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against redox environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075137 ! response to host redox environment is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075144 name: maintenance of symbiont tolerance to host iron concentration namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against iron concentration environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075139 ! response to host iron concentration is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075145 name: maintenance of symbiont tolerance to host defense molecules namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against defense molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075140 ! response to host defense molecules is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075146 name: maintenance of symbiont tolerance to host osmotic environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against osmotic environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075000 ! response to host osmotic environment is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075147 name: regulation of signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont signal transduction in response to host" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0075136 ! response to host [Term] id: GO:0075148 name: positive regulation of signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of symbiont signal transduction in response to host" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0075147 ! regulation of signal transduction in response to host [Term] id: GO:0075149 name: negative regulation of signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont signal transduction in response to host" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0075147 ! regulation of signal transduction in response to host [Term] id: GO:0075150 name: regulation of receptor-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] is_a: GO:0075147 ! regulation of signal transduction in response to host [Term] id: GO:0075151 name: positive regulation of receptor-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] is_a: GO:0075148 ! positive regulation of signal transduction in response to host is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host [Term] id: GO:0075152 name: negative regulation of receptor-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] is_a: GO:0075149 ! negative regulation of signal transduction in response to host is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host [Term] id: GO:0075153 name: regulation of transmembrane receptor-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host [Term] id: GO:0075154 name: positive regulation of transmembrane receptor-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] is_a: GO:0075151 ! positive regulation of receptor-mediated signal transduction in response to host is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host [Term] id: GO:0075155 name: negative regulation of transmembrane receptor-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] is_a: GO:0075152 ! negative regulation of receptor-mediated signal transduction in response to host is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host [Term] id: GO:0075156 name: regulation of G-protein coupled receptor protein signaling pathway in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah] synonym: "regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host [Term] id: GO:0075157 name: positive regulation of G-protein coupled receptor protein signaling pathway in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah] synonym: "positive regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0075154 ! positive regulation of transmembrane receptor-mediated signal transduction in response to host is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host [Term] id: GO:0075158 name: negative regulation of G-protein coupled receptor protein signaling pathway in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah] synonym: "negative regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0075155 ! negative regulation of transmembrane receptor-mediated signal transduction in response to host is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host [Term] id: GO:0075159 name: regulation of G-protein alpha subunit-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host [Term] id: GO:0075160 name: positive regulation of G-protein alpha subunit-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein signaling pathway in response to host is_a: GO:0075159 ! regulation of G-protein alpha subunit-mediated signal transduction in response to host [Term] id: GO:0075161 name: negative regulation of G-protein alpha subunit-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein signaling pathway in response to host is_a: GO:0075159 ! regulation of G-protein alpha subunit-mediated signal transduction in response to host [Term] id: GO:0075162 name: regulation of G-protein beta subunit-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host [Term] id: GO:0075163 name: positive regulation of G-protein beta subunit-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein signaling pathway in response to host is_a: GO:0075162 ! regulation of G-protein beta subunit-mediated signal transduction in response to host [Term] id: GO:0075164 name: negative regulation of G-protein beta subunit-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein signaling pathway in response to host is_a: GO:0075162 ! regulation of G-protein beta subunit-mediated signal transduction in response to host [Term] id: GO:0075165 name: regulation of G-protein gamma subunit-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host [Term] id: GO:0075166 name: positive regulation of G-protein gamma subunit-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein signaling pathway in response to host is_a: GO:0075165 ! regulation of G-protein gamma subunit-mediated signal transduction in response to host [Term] id: GO:0075167 name: negative regulation of G-protein gamma subunit-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein signaling pathway in response to host is_a: GO:0075165 ! regulation of G-protein gamma subunit-mediated signal transduction in response to host [Term] id: GO:0075168 name: regulation of protein kinase-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT [] is_a: GO:0075147 ! regulation of signal transduction in response to host [Term] id: GO:0075169 name: positive regulation of symbiont protein kinase-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075148 ! positive regulation of signal transduction in response to host is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host [Term] id: GO:0075170 name: negative regulation of protein kinase-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT [] is_a: GO:0075149 ! negative regulation of signal transduction in response to host is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host [Term] id: GO:0075171 name: regulation of MAP kinase-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host [Term] id: GO:0075172 name: positive regulation of MAP kinase-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] is_a: GO:0075169 ! positive regulation of symbiont protein kinase-mediated signal transduction in response to host is_a: GO:0075171 ! regulation of MAP kinase-mediated signal transduction in response to host [Term] id: GO:0075173 name: negative regulation of MAP kinase-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] is_a: GO:0075170 ! negative regulation of protein kinase-mediated signal transduction in response to host is_a: GO:0075171 ! regulation of MAP kinase-mediated signal transduction in response to host [Term] id: GO:0075174 name: regulation of cAMP-mediated signaling in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of cAMP-mediated signal transduction in response to host" EXACT [] synonym: "regulation of cAMP-mediated signalling in response to host" EXACT [] synonym: "regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] is_a: GO:0043949 ! regulation of cAMP-mediated signaling is_a: GO:0075147 ! regulation of signal transduction in response to host [Term] id: GO:0075175 name: positive regulation of cAMP-mediated signaling in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of cAMP-mediated signal transduction in response to host" EXACT [] synonym: "positive regulation of cAMP-mediated signalling in response to host" EXACT [] synonym: "positive regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] is_a: GO:0075148 ! positive regulation of signal transduction in response to host is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host [Term] id: GO:0075176 name: negative regulation of cAMP-mediated signaling in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of cAMP-mediated signal transduction in response to host" EXACT [] synonym: "negative regulation of cAMP-mediated signalling in response to host" EXACT [] synonym: "negative regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] is_a: GO:0043951 ! negative regulation of cAMP-mediated signaling is_a: GO:0075149 ! negative regulation of signal transduction in response to host is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host [Term] id: GO:0075177 name: regulation of calcium or calmodulin-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "modulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] synonym: "modulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] is_a: GO:0075147 ! regulation of signal transduction in response to host [Term] id: GO:0075178 name: positive regulation of calcium or calmodulin-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] synonym: "positive regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] is_a: GO:0075148 ! positive regulation of signal transduction in response to host is_a: GO:0075177 ! regulation of calcium or calmodulin-mediated signal transduction in response to host [Term] id: GO:0075179 name: negative regulation of calcium or calmodulin-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] synonym: "negative regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] is_a: GO:0075149 ! negative regulation of signal transduction in response to host is_a: GO:0075177 ! regulation of calcium or calmodulin-mediated signal transduction in response to host [Term] id: GO:0075180 name: regulation of transcription in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont transcription in response to host" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0075136 ! response to host [Term] id: GO:0075181 name: positive regulation of symbiont transcription in response to host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0075180 ! regulation of transcription in response to host [Term] id: GO:0075182 name: negative regulation of symbiont transcription in response to host namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process is_a: GO:0075180 ! regulation of transcription in response to host [Term] id: GO:0075183 name: infection cushion formation on or near host namespace: biological_process def: "The process in which an organized mass of hyphae is formed on or near the host organism, and numerous infective hyphae develop from the hyphae mass. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075015 ! formation of infection structure on or near host [Term] id: GO:0075184 name: regulation of infection cushion formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism relationship: regulates GO:0075183 ! infection cushion formation on or near host [Term] id: GO:0075185 name: positive regulation of infection cushion formation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075184 ! regulation of infection cushion formation on or near host relationship: positively_regulates GO:0075183 ! infection cushion formation on or near host [Term] id: GO:0075186 name: negative regulation of infection cushion formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0075184 ! regulation of infection cushion formation on or near host relationship: negatively_regulates GO:0075183 ! infection cushion formation on or near host [Term] id: GO:0075187 name: hyphopodium formation on or near host namespace: biological_process def: "The process in which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075015 ! formation of infection structure on or near host [Term] id: GO:0075188 name: regulation of hyphopodium formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044138 ! modulation of development of symbiont on or near host relationship: regulates GO:0075187 ! hyphopodium formation on or near host [Term] id: GO:0075189 name: positive regulation of hyphopodium formation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075188 ! regulation of hyphopodium formation on or near host relationship: positively_regulates GO:0075187 ! hyphopodium formation on or near host [Term] id: GO:0075190 name: negative regulation of hyphopodium formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075188 ! regulation of hyphopodium formation on or near host relationship: negatively_regulates GO:0075187 ! hyphopodium formation on or near host [Term] id: GO:0075191 name: autophagy of host cells on or near symbiont surface namespace: biological_process def: "The process in which the host cells digest parts of their own cytoplasm, occurring when the host is on or near its symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should be used to annotate gene products of host. is_a: GO:0075044 ! autophagy of host cells involved in interaction with symbiont [Term] id: GO:0075192 name: haustorium mother cell formation on or near host namespace: biological_process def: "The process in which a symbiont cell is formed on or near its host organism, via separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075015 ! formation of infection structure on or near host [Term] id: GO:0075193 name: regulation of haustorium mother cell formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044138 ! modulation of development of symbiont on or near host relationship: regulates GO:0075192 ! haustorium mother cell formation on or near host [Term] id: GO:0075194 name: positive regulation of haustorium mother cell formation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host relationship: positively_regulates GO:0075192 ! haustorium mother cell formation on or near host [Term] id: GO:0075195 name: negative regulation of haustorium mother cell formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host relationship: negatively_regulates GO:0075192 ! haustorium mother cell formation on or near host [Term] id: GO:0075196 name: adhesion of symbiont haustorium mother cell to host namespace: biological_process def: "The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont haustorium mother cell to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075197 name: formation of symbiont haustorium neck for entry into host namespace: biological_process def: "The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "symbiont haustorium neck formation for entry into host" EXACT [] is_a: GO:0075015 ! formation of infection structure on or near host relationship: part_of GO:0075052 ! entry into host via a specialized structure [Term] id: GO:0075198 name: modulation of symbiont haustorium neck formation for entry into host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0052372 ! modulation by symbiont of entry into host relationship: regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host [Term] id: GO:0075199 name: positive regulation of symbiont haustorium neck formation for entry into host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host is_a: GO:0075294 ! positive regulation by symbiont of entry into host relationship: positively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host [Term] id: GO:0075200 name: negative regulation of symbiont haustorium neck formation for entry into host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0052374 ! negative regulation by symbiont of entry into host is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host relationship: negatively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host [Term] id: GO:0075201 name: formation of symbiont penetration hypha for entry into host namespace: biological_process def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process in which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "symbiont penetration hypha formation for entry into host" EXACT [] is_a: GO:0075015 ! formation of infection structure on or near host relationship: part_of GO:0075052 ! entry into host via a specialized structure [Term] id: GO:0075202 name: modulation of symbiont penetration hypha formation for entry into host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0052372 ! modulation by symbiont of entry into host relationship: regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host [Term] id: GO:0075203 name: positive regulation of symbiont penetration hypha formation for entry into host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host is_a: GO:0075294 ! positive regulation by symbiont of entry into host relationship: positively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host [Term] id: GO:0075204 name: negative regulation of symbiont penetration hypha formation for entry into host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0052374 ! negative regulation by symbiont of entry into host is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host relationship: negatively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host [Term] id: GO:0075205 name: modulation by host of symbiont cAMP-mediated signal transduction namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The cAMP-mediated signal transduction is defined as a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host cAMP-mediated signal transduction ; GO:0075208". synonym: "modulation by host of symbiont cAMP-mediated signaling" RELATED [] synonym: "modulation by host of symbiont cAMP-mediated signalling" EXACT [] synonym: "regulation by host of symbiont cAMP-mediated signaling" EXACT [] is_a: GO:0043949 ! regulation of cAMP-mediated signaling is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway [Term] id: GO:0075206 name: positive regulation by host of symbiont cAMP-mediated signal transduction namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host cAMP-mediated signal transduction ; GO:0075209". synonym: "positive regulation by host of symbiont cAMP-mediated signaling" EXACT [] is_a: GO:0043950 ! positive regulation of cAMP-mediated signaling is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction [Term] id: GO:0075207 name: negative regulation by host of symbiont cAMP-mediated signal transduction namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host cAMP-mediated signal transduction ; GO:0075210". synonym: "negative regulation by host of symbiont cAMP-mediated signaling" EXACT [] is_a: GO:0043951 ! negative regulation of cAMP-mediated signaling is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction [Term] id: GO:0075208 name: modulation by symbiont of host cAMP-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont cAMP-mediated signal transduction ; GO:0075205". synonym: "modulation by symbiont of host cAMP-mediated signaling" EXACT [] is_a: GO:0043949 ! regulation of cAMP-mediated signaling is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0075209 name: positive regulation by symbiont of host cAMP-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075206". synonym: "positive regulation by symbiont of host cAMP-mediated signaling" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction [Term] id: GO:0075210 name: negative regulation by symbiont of host cAMP-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075207". synonym: "negative regulation by symbiont of host cAMP-mediated signaling" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction [Term] id: GO:0075211 name: regulation of transmembrane receptor-mediated cAMP signaling in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] synonym: "regulation of transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] synonym: "regulation of transmembrane receptor-mediated cAMP signalling in response to host" EXACT [] is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host [Term] id: GO:0075212 name: positive regulation of transmembrane receptor-mediated cAMP signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "positive regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" RELATED [] is_a: GO:0075154 ! positive regulation of transmembrane receptor-mediated signal transduction in response to host is_a: GO:0075175 ! positive regulation of cAMP-mediated signaling in response to host is_a: GO:0075211 ! regulation of transmembrane receptor-mediated cAMP signaling in response to host [Term] id: GO:0075213 name: negative regulation of transmembrane receptor-mediated cAMP signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "negative regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] is_a: GO:0075155 ! negative regulation of transmembrane receptor-mediated signal transduction in response to host is_a: GO:0075176 ! negative regulation of cAMP-mediated signaling in response to host is_a: GO:0075211 ! regulation of transmembrane receptor-mediated cAMP signaling in response to host [Term] id: GO:0075214 name: spore encystment on host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044132 ! development of symbiont on or near host [Term] id: GO:0075215 name: modulation of spore encystment on host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044138 ! modulation of development of symbiont on or near host relationship: regulates GO:0075214 ! spore encystment on host [Term] id: GO:0075216 name: positive regulation of spore encystment on host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075215 ! modulation of spore encystment on host relationship: positively_regulates GO:0075214 ! spore encystment on host [Term] id: GO:0075217 name: negative regulation of spore encystment on host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075215 ! modulation of spore encystment on host relationship: negatively_regulates GO:0075214 ! spore encystment on host [Term] id: GO:0075218 name: zoospore encystment on host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075214 ! spore encystment on host [Term] id: GO:0075219 name: modulation of zoospore encystment on host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075215 ! modulation of spore encystment on host relationship: regulates GO:0075218 ! zoospore encystment on host [Term] id: GO:0075220 name: positive regulation of zoospore encystment on host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075216 ! positive regulation of spore encystment on host is_a: GO:0075219 ! modulation of zoospore encystment on host relationship: positively_regulates GO:0075218 ! zoospore encystment on host [Term] id: GO:0075221 name: negative regulation of zoospore encystment on host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075217 ! negative regulation of spore encystment on host is_a: GO:0075219 ! modulation of zoospore encystment on host relationship: negatively_regulates GO:0075218 ! zoospore encystment on host [Term] id: GO:0075222 name: sporangium germination on or near host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth occurring on or near its host organism. A sporangium is a structure producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "direct germination on or near host" NARROW [] synonym: "germination of symbiont sporangium on or near host" EXACT [] synonym: "symbiont sporangium germination on or near host" EXACT [] is_a: GO:0043582 ! sporangium development is_a: GO:0044132 ! development of symbiont on or near host [Term] id: GO:0075223 name: modulation of sporangium germination on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporangium germination. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044138 ! modulation of development of symbiont on or near host is_a: GO:0075310 ! regulation of sporangium development relationship: regulates GO:0075222 ! sporangium germination on or near host [Term] id: GO:0075224 name: positive regulation of sporangium germination on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075223 ! modulation of sporangium germination on or near host is_a: GO:0075311 ! positive regulation of sporangium development relationship: positively_regulates GO:0075222 ! sporangium germination on or near host [Term] id: GO:0075225 name: negative regulation of sporangium germination on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075223 ! modulation of sporangium germination on or near host is_a: GO:0075312 ! negative regulation of sporangium development relationship: negatively_regulates GO:0075222 ! sporangium germination on or near host [Term] id: GO:0075226 name: encysted zoospore germination on or near host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in the symbiont encysted zoospore, which is on or near its host organism and germinates by developing a germ tube that may penetrate the host directly or indirectly through an appresorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075005 ! spore germination on or near host [Term] id: GO:0075227 name: modulation of encysted zoospore germination on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075006 ! modulation of spore germination on or near host relationship: regulates GO:0075226 ! encysted zoospore germination on or near host [Term] id: GO:0075228 name: positive regulation of encysted zoospore germination on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075007 ! positive regulation of spore germination on or near host is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host relationship: positively_regulates GO:0075226 ! encysted zoospore germination on or near host [Term] id: GO:0075229 name: negative regulation of encysted zoospore germination on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075008 ! negative regulation of spore germination on or near host is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host relationship: negatively_regulates GO:0075226 ! encysted zoospore germination on or near host [Term] id: GO:0075230 name: spore movement on or near host namespace: biological_process def: "Any process involved in the directed movement of a motile spore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052127 ! movement on or near host [Term] id: GO:0075231 name: modulation of spore movement on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism relationship: regulates GO:0075230 ! spore movement on or near host [Term] id: GO:0075232 name: positive regulation of spore movement on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0075231 ! modulation of spore movement on or near host relationship: positively_regulates GO:0075230 ! spore movement on or near host [Term] id: GO:0075233 name: negative regulation of spore movement on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0075231 ! modulation of spore movement on or near host relationship: negatively_regulates GO:0075230 ! spore movement on or near host [Term] id: GO:0075234 name: zoospore movement on or near host namespace: biological_process def: "Any process involved in the directed movement of a zoospore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "zoospore motility on or near host" EXACT [] is_a: GO:0075230 ! spore movement on or near host [Term] id: GO:0075235 name: modulation of zoospore movement on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zoospore movement on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "regulation of zoospore motility on or near host" EXACT [] is_a: GO:0075231 ! modulation of spore movement on or near host relationship: regulates GO:0075234 ! zoospore movement on or near host [Term] id: GO:0075236 name: positive regulation of zoospore movement on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075232 ! positive regulation of spore movement on or near host is_a: GO:0075235 ! modulation of zoospore movement on or near host relationship: positively_regulates GO:0075234 ! zoospore movement on or near host [Term] id: GO:0075237 name: negative regulation of zoospore movement on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075233 ! negative regulation of spore movement on or near host is_a: GO:0075235 ! modulation of zoospore movement on or near host relationship: negatively_regulates GO:0075234 ! zoospore movement on or near host [Term] id: GO:0075238 name: maintenance of symbiont tolerance to host pH environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against pH environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment is_a: GO:0075293 ! response to host pH environment [Term] id: GO:0075239 name: zoospore formation namespace: biological_process def: "The process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] is_a: GO:0034300 ! sporangiospore formation [Term] id: GO:0075240 name: regulation of zoospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] is_a: GO:0075286 ! regulation of sporangiospore formation relationship: regulates GO:0075239 ! zoospore formation [Term] id: GO:0075241 name: positive regulation of zoospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] is_a: GO:0075240 ! regulation of zoospore formation is_a: GO:0075287 ! positive regulation of sporangiospore formation relationship: positively_regulates GO:0075239 ! zoospore formation [Term] id: GO:0075242 name: negative regulation of zoospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] is_a: GO:0075240 ! regulation of zoospore formation is_a: GO:0075288 ! negative regulation of sporangiospore formation relationship: negatively_regulates GO:0075239 ! zoospore formation [Term] id: GO:0075243 name: oospore formation namespace: biological_process def: "The process in which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0075244 name: regulation of oospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore relationship: regulates GO:0075243 ! oospore formation [Term] id: GO:0075245 name: positive regulation of oospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075244 ! regulation of oospore formation relationship: positively_regulates GO:0075243 ! oospore formation [Term] id: GO:0075246 name: negative regulation of oospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075244 ! regulation of oospore formation relationship: negatively_regulates GO:0075243 ! oospore formation [Term] id: GO:0075247 name: aeciospore formation namespace: biological_process def: "The process in which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host." [GOC:pamgo_curators] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0075248 name: regulation of aeciospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore relationship: regulates GO:0075247 ! aeciospore formation [Term] id: GO:0075249 name: positive regulation of aeciospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075248 ! regulation of aeciospore formation relationship: positively_regulates GO:0075247 ! aeciospore formation [Term] id: GO:0075250 name: negative regulation of aeciospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075248 ! regulation of aeciospore formation relationship: negatively_regulates GO:0075247 ! aeciospore formation [Term] id: GO:0075251 name: uredospore formation namespace: biological_process def: "The process which specific outcome is the formation of an asexual, dikaryotic, often rusty-colored spore, produced in a structure called a uredinium; mostly found in the rust fungus." [GOC:pamgo_curators] synonym: "urediniospore formation" EXACT [] synonym: "ureidospore formation" EXACT [] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0075252 name: regulation of uredospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] synonym: "regulation of ureidospore formation" EXACT [] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore relationship: regulates GO:0075251 ! uredospore formation [Term] id: GO:0075253 name: positive regulation of uredospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] synonym: "positive regulation of ureidospore formation" EXACT [] is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075252 ! regulation of uredospore formation relationship: positively_regulates GO:0075251 ! uredospore formation [Term] id: GO:0075254 name: negative regulation of uredospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] synonym: "negative regulation of ureidospore formation" EXACT [] is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075252 ! regulation of uredospore formation relationship: negatively_regulates GO:0075251 ! uredospore formation [Term] id: GO:0075255 name: teliospore formation namespace: biological_process def: "The set of processes leading to the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0075256 name: regulation of teliospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore relationship: regulates GO:0075255 ! teliospore formation [Term] id: GO:0075257 name: positive regulation of teliospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075256 ! regulation of teliospore formation relationship: positively_regulates GO:0075255 ! teliospore formation [Term] id: GO:0075258 name: negative regulation of teliospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075256 ! regulation of teliospore formation relationship: negatively_regulates GO:0075255 ! teliospore formation [Term] id: GO:0075259 name: spore-bearing organ development namespace: biological_process def: "The process whose specific outcome is the progression of a spore-bearing organ over time, from its formation to the mature structure. A spore-bearing organ is an anatomical structure that produces new spores." [GOC:mah, GOC:mcc, GOC:pamgo_curators] synonym: "fruiting structure development" EXACT [] is_a: GO:0048513 ! organ development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0075260 name: regulation of spore-bearing organ development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0075259 ! spore-bearing organ development [Term] id: GO:0075261 name: positive regulation of spore-bearing organ development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0075260 ! regulation of spore-bearing organ development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0075259 ! spore-bearing organ development [Term] id: GO:0075262 name: negative regulation of spore-bearing organ development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0075260 ! regulation of spore-bearing organ development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0075259 ! spore-bearing organ development [Term] id: GO:0075263 name: oogonium development namespace: biological_process def: "The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes." [GOC:pamgo_curators] is_a: GO:0075259 ! spore-bearing organ development [Term] id: GO:0075264 name: regulation of oogonium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0075263 ! oogonium development [Term] id: GO:0075265 name: positive regulation of oogonium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075264 ! regulation of oogonium development relationship: positively_regulates GO:0075263 ! oogonium development [Term] id: GO:0075266 name: negative regulation of oogonium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075264 ! regulation of oogonium development relationship: negatively_regulates GO:0075263 ! oogonium development [Term] id: GO:0075267 name: aecium development namespace: biological_process def: "The process in which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium." [GOC:pamgo_curators] is_a: GO:0030582 ! fruiting body development [Term] id: GO:0075268 name: regulation of aecium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] is_a: GO:0031155 ! regulation of fruiting body development relationship: regulates GO:0075267 ! aecium development [Term] id: GO:0075269 name: positive regulation of aecium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075268 ! regulation of aecium development relationship: positively_regulates GO:0075267 ! aecium development [Term] id: GO:0075270 name: negative regulation of aecium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075268 ! regulation of aecium development relationship: negatively_regulates GO:0075267 ! aecium development [Term] id: GO:0075271 name: zygosporangium development namespace: biological_process def: "The process in which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes." [GOC:pamgo_curators] is_a: GO:0075259 ! spore-bearing organ development [Term] id: GO:0075272 name: regulation of zygosporangium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0075271 ! zygosporangium development [Term] id: GO:0075273 name: positive regulation of zygosporangium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075272 ! regulation of zygosporangium development relationship: positively_regulates GO:0075271 ! zygosporangium development [Term] id: GO:0075274 name: negative regulation of zygosporangium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075272 ! regulation of zygosporangium development relationship: negatively_regulates GO:0075271 ! zygosporangium development [Term] id: GO:0075275 name: telium development namespace: biological_process def: "The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] is_a: GO:0075259 ! spore-bearing organ development [Term] id: GO:0075276 name: regulation of telium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0075275 ! telium development [Term] id: GO:0075277 name: positive regulation of telium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075276 ! regulation of telium development relationship: positively_regulates GO:0075275 ! telium development [Term] id: GO:0075278 name: negative regulation of telium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075276 ! regulation of telium development relationship: negatively_regulates GO:0075275 ! telium development [Term] id: GO:0075279 name: uredinium development namespace: biological_process def: "The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] synonym: "development of uredium" EXACT [] is_a: GO:0075259 ! spore-bearing organ development [Term] id: GO:0075280 name: regulation of uredinium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0075279 ! uredinium development [Term] id: GO:0075281 name: positive regulation of uredinium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075280 ! regulation of uredinium development relationship: positively_regulates GO:0075279 ! uredinium development [Term] id: GO:0075282 name: negative regulation of uredinium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075280 ! regulation of uredinium development relationship: negatively_regulates GO:0075279 ! uredinium development [Term] id: GO:0075283 name: sporulation resulting in formation of a multicellular or syncytial spore namespace: biological_process def: "The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure." [GOC:pamgo_curators] synonym: "multicellular or syncytial spore formation by sporulation" EXACT [GOC:dph, GOC:tb] is_a: GO:0043934 ! sporulation [Term] id: GO:0075284 name: asexual sporulation resulting in formation of a multicellular or syncytial spore namespace: biological_process def: "The formation of a multicellular or syncytial spore via septations derived from mitosis." [GOC:pamgo_curators] is_a: GO:0030436 ! asexual sporulation is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore [Term] id: GO:0075285 name: sexual sporulation resulting in formation of a multicellular or syncytial spore namespace: biological_process def: "The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] is_a: GO:0034293 ! sexual sporulation is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore [Term] id: GO:0075286 name: regulation of sporangiospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore relationship: regulates GO:0034300 ! sporangiospore formation [Term] id: GO:0075287 name: positive regulation of sporangiospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075286 ! regulation of sporangiospore formation relationship: positively_regulates GO:0034300 ! sporangiospore formation [Term] id: GO:0075288 name: negative regulation of sporangiospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075286 ! regulation of sporangiospore formation relationship: negatively_regulates GO:0034300 ! sporangiospore formation [Term] id: GO:0075289 name: aplanospore formation namespace: biological_process def: "The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] is_a: GO:0034300 ! sporangiospore formation [Term] id: GO:0075290 name: regulation of aplanospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] is_a: GO:0075286 ! regulation of sporangiospore formation relationship: regulates GO:0075289 ! aplanospore formation [Term] id: GO:0075291 name: positive regulation of aplanospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] is_a: GO:0075287 ! positive regulation of sporangiospore formation is_a: GO:0075290 ! regulation of aplanospore formation relationship: positively_regulates GO:0075289 ! aplanospore formation [Term] id: GO:0075292 name: negative regulation of aplanospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] is_a: GO:0075288 ! negative regulation of sporangiospore formation is_a: GO:0075290 ! regulation of aplanospore formation relationship: negatively_regulates GO:0075289 ! aplanospore formation [Term] id: GO:0075293 name: response to host pH environment namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "response of symbiont to host pH environment" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075294 name: positive regulation by symbiont of entry into host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators] synonym: "activation by symbiont of entry into host" NARROW [] synonym: "up regulation by symbiont of entry into host" EXACT [] synonym: "up-regulation by symbiont of entry into host" EXACT [] synonym: "upregulation by symbiont of entry into host" EXACT [] is_a: GO:0052372 ! modulation by symbiont of entry into host is_a: GO:0075295 ! positive regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0075295 name: positive regulation by organism of entry into other organism involved in symbiotic interaction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators] synonym: "activation by organism of entry into other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "up regulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of entry into other organism during symbiotic interaction" RELATED [] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0075296 name: positive regulation of ascospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0034307 ! regulation of ascospore formation is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore relationship: positively_regulates GO:0030437 ! ascospore formation [Term] id: GO:0075297 name: negative regulation of ascospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0034307 ! regulation of ascospore formation is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore relationship: negatively_regulates GO:0030437 ! ascospore formation [Term] id: GO:0075298 name: regulation of zygospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore relationship: regulates GO:0034296 ! zygospore formation [Term] id: GO:0075299 name: positive regulation of zygospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075298 ! regulation of zygospore formation relationship: positively_regulates GO:0034296 ! zygospore formation [Term] id: GO:0075300 name: negative regulation of zygospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075298 ! regulation of zygospore formation relationship: negatively_regulates GO:0034296 ! zygospore formation [Term] id: GO:0075301 name: cell differentiation involved in spore germination namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a specific cell type occurring during spore germination, the physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth." [GOC:jl] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009847 ! spore germination [Term] id: GO:0075302 name: regulation of basidiospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore relationship: regulates GO:0034295 ! basidiospore formation [Term] id: GO:0075303 name: positive regulation of basidiospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075302 ! regulation of basidiospore formation relationship: positively_regulates GO:0034295 ! basidiospore formation [Term] id: GO:0075304 name: negative regulation of basidiospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075302 ! regulation of basidiospore formation relationship: negatively_regulates GO:0034295 ! basidiospore formation [Term] id: GO:0075305 name: modulation of growth or development of symbiont on or near host namespace: biological_process def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'modulation of growth of symbiont on or near host ; GO:0044139' and 'modulation of development of symbiont on or near host ; GO:0044138'. synonym: "modulation of growth or development of symbiont on or near host surface" EXACT [] is_obsolete: true replaced_by: GO:0044138 replaced_by: GO:0044139 [Term] id: GO:0075306 name: regulation of conidium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0034305 ! regulation of asexual sporulation relationship: regulates GO:0048315 ! conidium formation [Term] id: GO:0075307 name: positive regulation of conidium formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators] is_a: GO:0043938 ! positive regulation of sporulation is_a: GO:0075306 ! regulation of conidium formation relationship: positively_regulates GO:0048315 ! conidium formation [Term] id: GO:0075308 name: negative regulation of conidium formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators] is_a: GO:0043939 ! negative regulation of sporulation is_a: GO:0075306 ! regulation of conidium formation relationship: negatively_regulates GO:0048315 ! conidium formation [Term] id: GO:0075309 name: negative regulation of growth or development of symbiont on or near host surface namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont on or near host surface ; GO:0044141' and 'negative regulation of growth of symbiont on or near host surface ; GO:0044140'. is_obsolete: true replaced_by: GO:0044140 replaced_by: GO:0044141 [Term] id: GO:0075310 name: regulation of sporangium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0043582 ! sporangium development [Term] id: GO:0075311 name: positive regulation of sporangium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075310 ! regulation of sporangium development relationship: positively_regulates GO:0043582 ! sporangium development [Term] id: GO:0075312 name: negative regulation of sporangium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075310 ! regulation of sporangium development relationship: negatively_regulates GO:0043582 ! sporangium development [Term] id: GO:0075313 name: basidium development namespace: biological_process def: "The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] is_a: GO:0075259 ! spore-bearing organ development [Term] id: GO:0075314 name: regulation of basidium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basidium development, a process that leads to the formation of a basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0075313 ! basidium development [Term] id: GO:0075315 name: positive regulation of basidium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075314 ! regulation of basidium development relationship: positively_regulates GO:0075313 ! basidium development [Term] id: GO:0075316 name: negative regulation of basidium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075314 ! regulation of basidium development relationship: negatively_regulates GO:0075313 ! basidium development [Term] id: GO:0075317 name: ascus development namespace: biological_process def: "The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] is_a: GO:0075259 ! spore-bearing organ development [Term] id: GO:0075318 name: regulation of ascus development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ascus development, a process that leads to the formation of basidium, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0075317 ! ascus development [Term] id: GO:0075319 name: positive regulation of ascus development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075318 ! regulation of ascus development relationship: positively_regulates GO:0075317 ! ascus development [Term] id: GO:0075320 name: negative regulation of ascus development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075318 ! regulation of ascus development relationship: negatively_regulates GO:0075317 ! ascus development [Term] id: GO:0075321 name: oomycete sporangium development namespace: biological_process def: "The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated." [GOC:pamgo_curators] is_a: GO:0030436 ! asexual sporulation is_a: GO:0043582 ! sporangium development [Term] id: GO:0075322 name: regulation of oomycete sporangium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] is_a: GO:0034305 ! regulation of asexual sporulation is_a: GO:0075310 ! regulation of sporangium development relationship: regulates GO:0075321 ! oomycete sporangium development [Term] id: GO:0075323 name: positive regulation of oomycete sporangium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] is_a: GO:0043938 ! positive regulation of sporulation is_a: GO:0075311 ! positive regulation of sporangium development is_a: GO:0075322 ! regulation of oomycete sporangium development relationship: positively_regulates GO:0075321 ! oomycete sporangium development [Term] id: GO:0075324 name: negative regulation of oomycete sporangium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] is_a: GO:0043939 ! negative regulation of sporulation is_a: GO:0075312 ! negative regulation of sporangium development is_a: GO:0075322 ! regulation of oomycete sporangium development relationship: negatively_regulates GO:0075321 ! oomycete sporangium development [Term] id: GO:0075325 name: spore dispersal on or near host namespace: biological_process def: "Any process in which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "spore dispersal on or near host during symbiotic interaction" EXACT [] is_a: GO:0051701 ! interaction with host [Term] id: GO:0075326 name: active spore dispersal on or near host namespace: biological_process def: "Any active process in which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "active spore dispersal on or near host during symbiotic interaction" EXACT [] is_a: GO:0075325 ! spore dispersal on or near host [Term] id: GO:0075327 name: passive spore dispersal on or near host namespace: biological_process def: "Any passive process in which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "passive spore dispersal on or near host during symbiotic interaction" EXACT [] is_a: GO:0075325 ! spore dispersal on or near host [Term] id: GO:0075328 name: formation by symbiont of arbuscule for nutrient acquisition from host namespace: biological_process def: "The assembly by an organism of an arbuscule, a fine, tree-like hyphal structure projected into the host cell for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host [Term] id: GO:0075329 name: regulation of arbuscule formation for nutrient acquisition from host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0060259 ! regulation of feeding behavior relationship: regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host [Term] id: GO:0075330 name: positive regulation of arbuscule formation for nutrient acquisition from host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host relationship: positively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host [Term] id: GO:0075331 name: negative regulation of arbuscule formation for nutrient acquisition from host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host relationship: negatively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host [Term] id: GO:0075332 name: modulation by host of symbiont adenylate cyclase-mediated signal transduction namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075335". is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway [Term] id: GO:0075333 name: positive regulation by host of symbiont adenylate cyclase-mediated signal transduction namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075336". is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway is_a: GO:0075332 ! modulation by host of symbiont adenylate cyclase-mediated signal transduction [Term] id: GO:0075334 name: modulation of symbiont adenylate cyclase-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075147 ! regulation of signal transduction in response to host [Term] id: GO:0075335 name: positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075148 ! positive regulation of signal transduction in response to host is_a: GO:0075334 ! modulation of symbiont adenylate cyclase-mediated signal transduction in response to host [Term] id: GO:0075336 name: negative regulation of symbiont adenylate cyclase-mediated signal transduction in response to host namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075149 ! negative regulation of signal transduction in response to host is_a: GO:0075334 ! modulation of symbiont adenylate cyclase-mediated signal transduction in response to host [Term] id: GO:0075337 name: positive regulation of growth or development of symbiont on or near host surface namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont on or near host surface ; GO:0044143' and 'positive regulation of growth of symbiont on or near host surface ; GO:0044142'. is_obsolete: true replaced_by: GO:0044142 replaced_by: GO:0044143 [Term] id: GO:0075338 name: modulation of growth or development of symbiont during interaction with host namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'modulation of development of symbiont during interaction with host ; GO:0044145' and 'modulation of growth of symbiont during interaction with host ; GO:0044144'. is_obsolete: true replaced_by: GO:0044144 replaced_by: GO:0044145 [Term] id: GO:0075339 name: positive regulation of growth or development of symbiont during interaction with host namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont during interaction with host ; GO:0044149' and 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'. is_obsolete: true [Term] id: GO:0075340 name: negative regulation of growth or development of symbiont during interaction with host namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont during interaction with host ; GO:0044147' and 'negative regulation of growth of symbiont during interaction with host ; GO:0044146'. is_obsolete: true replaced_by: GO:0044146 replaced_by: GO:0044147 [Term] id: GO:0075341 name: host cell PML body namespace: cellular_component def: "A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism." [GOC:BHF, GOC:jl] synonym: "host cell PML NB" EXACT [] synonym: "host cell PML nuclear body" EXACT [] is_a: GO:0044094 ! host cell nuclear part [Term] id: GO:0075342 name: disassembly by symbiont of host cell PML body namespace: biological_process def: "The breakdown, by the symbiont, of a PML body within a host cell. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:BHF, GOC:jl] synonym: "catabolism by symbiont of host cell PML body" EXACT [] synonym: "degradation by symbiont of host cell PML body" EXACT [] synonym: "disassembly by symbiont of host cell PML body during symbiotic interaction" EXACT [] synonym: "disassembly by symbiont of host cell PML NB" EXACT [] synonym: "disassembly by symbiont of host cell PML nuclear body" EXACT [] synonym: "disruption by symbiont of host cell PML body" EXACT [] is_a: GO:0052008 ! disassembly by symbiont of host cellular component [Term] id: GO:0075343 name: modulation by symbiont of abscisic acid levels in host namespace: biological_process def: "The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate abscisic acid levels in the host, consider annotating to 'regulation of abscisic acid mediated signaling ; GO:0009787' or 'regulation of abscisic acid biosynthetic process ; GO:0010115'. is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels [Term] id: GO:0075344 name: modulation by symbiont of host protein levels namespace: biological_process def: "The alteration by an organism of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0075345 name: modification by symbiont of host protein namespace: biological_process def: "The covalent alteration by an organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that modify host proteins, consider annotation to 'protein modification process' GO:0006464. subset: gosubset_prok is_a: GO:0052228 ! metabolism by symbiont of host protein [Term] id: GO:0075346 name: modification by symbiont of host protein by ubiquitination namespace: biological_process def: "The process in which an organism adds one or more ubiquitin groups to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that ubiquitinate host proteins, consider annotation to 'protein ubiquitination ; GO:0016567'. synonym: "modification by symbiont of host protein by ubiquitinylation" EXACT [] synonym: "modification by symbiont of host protein by ubiquitylation " EXACT [] is_a: GO:0075345 ! modification by symbiont of host protein [Term] id: GO:0080001 name: mucilage extrusion from seed coat namespace: biological_process def: "The process in which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat." [PMID:18266922] synonym: "mucilage release from seed coat" RELATED [] synonym: "secretion of mucilage from seed coat" RELATED [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0009845 ! seed germination relationship: part_of GO:0048316 ! seed development [Term] id: GO:0080002 name: UDP-glucose:4-aminobenzoate acylglucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP." [EC:2.4.1.-, PMID:18385129] synonym: "UDP-glucose:p-aminobenzoate acylglucosyltransferase activity" RELATED [] synonym: "UDP-glucose:p-aminobenzoate glucosyltransferase activity" RELATED [] synonym: "UDP-glucose:pABA acylglucosyltransferase activity" RELATED [] xref: MetaCyc:RXN-6142 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080003 name: thalianol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the triterpene thalianol." [PMID:18356490] synonym: "thalianol metabolism" EXACT [GOC:tair_curators] is_a: GO:0010683 ! tricyclic triterpenoid metabolic process [Term] id: GO:0080004 name: thalian-diol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15." [PMID:18356490] xref: EC:1.14.21.- xref: MetaCyc:RXN-9637 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0080005 name: photosystem stoichiometry adjustment namespace: biological_process def: "Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis." [PMID:11607105] is_a: GO:0010109 ! regulation of photosynthesis [Term] id: GO:0080006 name: internode patterning namespace: biological_process def: "Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached." [GOC:tb] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0048367 ! shoot development [Term] id: GO:0080007 name: S-nitrosoglutathione reductase activity namespace: molecular_function def: "Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+." [MetaCyc:RXN-10742, PMID:11260719] xref: MetaCyc:RXN-10742 is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0080008 name: CUL4 RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0080009 name: mRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803] is_a: GO:0001510 ! RNA methylation is_a: GO:0016556 ! mRNA modification [Term] id: GO:0080010 name: regulation of oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [PMID:18450450] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. is_obsolete: true consider: GO:2000374 consider: GO:2000377 [Term] id: GO:0080011 name: baruol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol." [MetaCyc:RXN-9685, PMID:17705488] xref: EC:5.4.99.- xref: MetaCyc:RXN-9685 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0080012 name: trihydroxyferuloyl spermidine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+." [PMID:18557837] synonym: "N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity" EXACT [MetaCyc:RXN-11263] xref: EC:2.1.1.- xref: MetaCyc:RXN-11263 is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0080013 name: (E,E)-geranyllinalool synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate." [MetaCyc:RXN-10441, PMID:18398052] xref: MetaCyc:RXN-10441 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0080014 name: thalianol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X." [MetaCyc:RXN-9631, PMID:17474751, PMID:18356490] comment: In Field and Osbourn 2008 (PMID:18356490), thalianol is referred to as (3S,13S,3R)-malabarica-8,17,21-trien-3-ol and thalian-diol is referred to as (3S,13S,14R)-malabarica-8,17,21-trien-3,?-diol, but the error in this naming system was pointed out in Kolesnikova 2007 (PMID:17474751). The new names used in the definition have been approved by the authors (Field and Osbourn 2008). xref: EC:1.14.13.- xref: MetaCyc:RXN-9631 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0080015 name: sabinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate." [MetaCyc:RXN-5103, PMID:12566586, PMID:9747540] xref: EC:4.2.3.- xref: MetaCyc:RXN-5103 is_a: GO:0009975 ! cyclase activity is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0080016 name: (-)-E-beta-caryophyllene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate." [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047] xref: EC:4.2.3.- xref: MetaCyc:RXN-8414 is_a: GO:0009975 ! cyclase activity is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0080017 name: alpha-humulene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate." [PMID:12566586, PMID:9442047] xref: EC:4.2.3.- xref: MetaCyc:RXN-8415 is_a: GO:0009975 ! cyclase activity is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0080018 name: anthocyanin 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP." [PMID:15807784] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080019 name: fatty-acyl-CoA reductase (alcohol-forming) activity namespace: molecular_function def: "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH = a very long chain primary alcohol + NADP + CoA." [PMID:16980563] synonym: "fatty acyl CoA reductase (alcohol-forming) activity" EXACT [GOC:curators] synonym: "fatty acyl-CoA reductase (alcohol-forming) activity" EXACT [GOC:mah] is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0080020 name: regulation of coenzyme A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A." [PMID:18621975] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0009118 ! regulation of nucleoside metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process relationship: regulates GO:0015937 ! coenzyme A biosynthetic process [Term] id: GO:0080021 name: response to benzoic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [PMID:18753285] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0080022 name: primary root development namespace: biological_process def: "The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle." [GOC:dhl] is_a: GO:0048364 ! root development [Term] id: GO:0080023 name: 3R-hydroxyacyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O." [PMID:16982622] is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0080024 name: indolebutyric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants." [PMID:18725356] synonym: "IBA metabolic process" EXACT [] synonym: "IBA metabolism" EXACT [] synonym: "indole-3-butyric acid metabolic process" NARROW [] is_a: GO:0009850 ! auxin metabolic process [Term] id: GO:0080025 name: phosphatidylinositol-3,5-bisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324] synonym: "PtdIns(3,5)P2 binding" EXACT [] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0080026 name: response to indolebutyric acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [PMID:18725356] synonym: "response to IBA stimulus" EXACT [] synonym: "response to indole-3-butyric acid stimulus" NARROW [] is_a: GO:0009733 ! response to auxin stimulus [Term] id: GO:0080027 name: response to herbivore namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore." [PMID:18987211] is_a: GO:0051707 ! response to other organism [Term] id: GO:0080028 name: nitrile biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [PMID:18987211] is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0080029 name: cellular response to boron-containing substance levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of boron-containing substances." [PMID:18952773] synonym: "cellular response to boron levels" EXACT [GOC:curators] is_a: GO:0010036 ! response to boron-containing substance is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0080030 name: methyl indole-3-acetate esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+." [MetaCyc:RXN-10711, PMID:18467465] synonym: "indole-3-Acetic acid methyl ester esterase activity" EXACT [] synonym: "MeIAA esterase activity" EXACT [] synonym: "Methyl IAA esterase activity" EXACT [] synonym: "methyl indole-3-acetate esterase activity" RELATED [] xref: EC:3.1.1.1 xref: MetaCyc:RXN-10711 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0080031 name: methyl salicylate esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+." [MetaCyc:RXNQT-4366, PMID:18467465, PMID:18643994] synonym: "MESA esterase activity" EXACT [] synonym: "methyl SA esterase activity" EXACT [] synonym: "methylsalicylate esterase activity" EXACT [] synonym: "salicylic acid methyl ester esterase activity" EXACT [] xref: EC:3.1.1.1 xref: MetaCyc:RXNQT-4366 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0080032 name: methyl jasmonate esterase activity namespace: molecular_function def: "Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol." [PMID:15233793, PMID:18467465] synonym: "jasmonic acid methyl ester esterase activity" EXACT [] synonym: "MEJA esterase activity" EXACT [] synonym: "methyl JA esterase activity" EXACT [] xref: EC:3.1.1.1 xref: MetaCyc:RXN-10767 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0080033 name: response to nitrite namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:dhl, PMID:17951451] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0080034 name: host response to induction by symbiont of tumor, nodule or growth in host namespace: biological_process def: "Any process that results in a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the formation of an abnormal mass of cells in the host organism, induced by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18836040] is_a: GO:0009608 ! response to symbiont [Term] id: GO:0080035 name: 2-hydroxy-but-3-enyl glucosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of progoitrin, a 2-hydroxy-but-3-enyl glucosinolate. Glucosinolates are substituted thioglucosides found in rapeseed products and related cruciferae, and progoitrin has been implicated in causing goiters in mammals and bitter taste in cruciferous vegetables." [PMID:11560911, PMID:18945935] synonym: "2-hydroxy-but-3-enyl glucosinolate anabolism" EXACT [] synonym: "2-hydroxy-but-3-enyl glucosinolate biosynthesis" EXACT [] synonym: "2-hydroxy-but-3-enyl glucosinolate formation" EXACT [] synonym: "2-hydroxy-but-3-enyl glucosinolate synthesis" EXACT [] synonym: "progoitrin biosynthesis" EXACT [] synonym: "progoitrin biosynthetic process" EXACT [] synonym: "progoitrin synthesis" EXACT [] is_a: GO:0019761 ! glucosinolate biosynthetic process [Term] id: GO:0080036 name: regulation of cytokinin mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by cytokinin." [GOC:dhl] synonym: "regulation of cytokinin mediated signalling" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0009736 ! cytokinin mediated signaling pathway [Term] id: GO:0080037 name: negative regulation of cytokinin mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by cytokinin." [GOC:dhl, PMID:14973166] synonym: "negative regulation of cytokinin mediated signalling" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0080036 ! regulation of cytokinin mediated signaling pathway relationship: negatively_regulates GO:0009736 ! cytokinin mediated signaling pathway [Term] id: GO:0080038 name: positive regulation of cytokinin mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by cytokinin." [GOC:dhl] synonym: "positive regulation of cytokinin mediated signalling" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0080036 ! regulation of cytokinin mediated signaling pathway relationship: positively_regulates GO:0009736 ! cytokinin mediated signaling pathway [Term] id: GO:0080039 name: xyloglucan endotransglucosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a beta-(1,4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207, GOC:ask, PMID:1400418, PMID:1554366] is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0080040 name: positive regulation of cellular response to phosphate starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to phosphate starvation." [PMID:18315545] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress relationship: positively_regulates GO:0016036 ! cellular response to phosphate starvation [Term] id: GO:0080041 name: ADP-ribose pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate." [GOC:tb] is_a: GO:0019144 ! ADP-sugar diphosphatase activity [Term] id: GO:0080042 name: ADP-glucose pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate." [GOC:tb] is_a: GO:0019144 ! ADP-sugar diphosphatase activity [Term] id: GO:0080043 name: quercetin 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule." [PMID:15352060] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080044 name: quercetin 7-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule." [PMID:15352060] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080045 name: quercetin 3'-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule." [PMID:15352060] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080046 name: quercetin 4'-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule." [PMID:15352060] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080047 name: GDP-L-galactose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + phosphate = L-galactose-1-P + GDP." [PMID:18463094] is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0080048 name: GDP-D-glucose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP." [PMID:18463094] is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0080049 name: L-gulono-1,4-lactone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [PMID:18190525] is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor [Term] id: GO:0080050 name: regulation of seed development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed development." [PMID:19141706] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0048316 ! seed development [Term] id: GO:0080051 name: cutin transport namespace: biological_process def: "The directed movement of cutin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cutin, which consists of C16-18 fatty acids, is the major component of the cuticle that covers the plant surface." [PMID:17951461] is_a: GO:0015909 ! long-chain fatty acid transport [Term] id: GO:0080052 name: response to histidine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [PMID:15889294] is_a: GO:0043200 ! response to amino acid stimulus [Term] id: GO:0080053 name: response to phenylalanine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [PMID:15889294] is_a: GO:0043200 ! response to amino acid stimulus [Term] id: GO:0080054 name: low affinity nitrate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [PMID:19050168] is_a: GO:0015112 ! nitrate transmembrane transporter activity [Term] id: GO:0080055 name: low affinity nitrate transport namespace: biological_process def: "The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [PMID:19050168] is_a: GO:0015706 ! nitrate transport [Term] id: GO:0080056 name: petal vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the petal of vascular plants." [PMID:17369435] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0080057 name: sepal vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the sepal of vascular plants." [PMID:17369435] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0080058 name: protein deglutathionylation namespace: biological_process def: "The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage." [GOC:tb] synonym: "protein amino acid deglutathionylation" EXACT [GOC:bf] is_a: GO:0006464 ! protein modification process [Term] id: GO:0080059 name: flavonol 3-O-arabinosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside." [PMID:18757557] is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0052636 ! arabinosyltransferase activity [Term] id: GO:0080060 name: integument development namespace: biological_process def: "The process whose specific outcome is the progression of the integument over time, from its formation to the mature structure. Integument is one of the layers of tissue that usually covers the ovule, enveloping the nucellus and forming the micropyle at the apex." [PMID:19054366, PO:0020021] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009888 ! tissue development relationship: part_of GO:0048481 ! ovule development [Term] id: GO:0080061 name: indole-3-acetonitrile nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3." [EC:3.5.5.1, MetaCyc:RXN-1404] is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0080062 name: cytokinin 9-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [KEGG:R08369, PMID:15342621] xref: EC:2.4.1.- xref: KEGG:R08369 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080064 name: 4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy, 4-beta-methyl-9beta,19-cyclopropylsterol + 3 NADP+ + 3 H2O. This overall reaction proceeds through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH)." [PMID:14653780] is_a: GO:0000254 ! C-4 methylsterol oxidase activity [Term] id: GO:0080065 name: 4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O. This overall reaction proceeds through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH)." [PMID:14653780] is_a: GO:0000254 ! C-4 methylsterol oxidase activity [Term] id: GO:0080066 name: 3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity [Term] id: GO:0080067 name: 4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity [Term] id: GO:0080068 name: 5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity [Term] id: GO:0080069 name: 7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity [Term] id: GO:0080070 name: 8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity [Term] id: GO:0080071 name: indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity [Term] id: GO:0080072 name: spermidine:sinapoyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0080073 name: spermidine:coumaroyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0080074 name: spermidine:caffeoyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0080075 name: spermidine:feruloyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0080076 name: caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule." [PMID:19077165] is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0080077 name: trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule." [PMID:19077165] is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0080078 name: tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule." [PMID:19077165] is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0080079 name: cellobiose glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: cellobiose + H2O = 2 D-glucose." [PMID:15604686] synonym: "cellobiose glucohydrolase activity" EXACT [] xref: MetaCyc:RXN-10773 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0080081 name: 4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside." [PMID:15604686] is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0080082 name: esculin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosidic link in esculin." [PMID:15604686] is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0080083 name: beta-gentiobiose beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose." [PMID:15604686] is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0080084 name: 5S rDNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 5S rDNA sequence encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists." [PMID:12711688] is_a: GO:0000182 ! rDNA binding [Term] id: GO:0080085 name: signal recognition particle, chloroplast targeting namespace: cellular_component def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast." [PMID:17513500] is_a: GO:0048500 ! signal recognition particle [Term] id: GO:0080086 name: stamen filament development namespace: biological_process def: "The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen." [PMID:19139039, PO:0009067] synonym: "filament development" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048443 ! stamen development [Term] id: GO:0080087 name: callose binding namespace: molecular_function def: "Interacting selectively and non-covalently with callose. Callose is a linear 1,3-beta-D-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:dhl] synonym: "callose binding" EXACT [] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0080088 name: spermidine hydroxycinnamate conjugate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermidine hydroxycinnamate conjugates." [PMID:19077165] is_a: GO:0006596 ! polyamine biosynthetic process [Term] id: GO:0080089 name: sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule." [PMID:19168716] is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0080090 name: regulation of primary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0044238 ! primary metabolic process [Term] id: GO:0080091 name: regulation of raffinose metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving raffinose." [PMID:19211694] is_a: GO:0006109 ! regulation of carbohydrate metabolic process relationship: regulates GO:0033530 ! raffinose metabolic process [Term] id: GO:0080092 name: regulation of pollen tube growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pollen tube growth." [PMID:19208902] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051510 ! regulation of unidimensional cell growth is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0009860 ! pollen tube growth [Term] id: GO:0080093 name: regulation of photorespiration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of photorespiration. Photorespiration is a light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved." [GOC:tb] is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0009853 ! photorespiration [Term] id: GO:0080094 name: response to trehalose-6-phosphate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [PMID:19193861] is_a: GO:0034285 ! response to disaccharide stimulus [Term] id: GO:0080095 name: phosphatidylethanolamine-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine." [PMID:16020547] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0080096 name: phosphatidate-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate." [PMID:16020547] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0080097 name: L-tryptophan:pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + pyruvate = indolepyruvate + L-alanine." [PMID:18394996] comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.28 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.28; note: 3-indole-2-oxopropanoate = indolepyruvate). xref: MetaCyc:RXN-10139 is_a: GO:0070529 ! L-tryptophan aminotransferase activity [Term] id: GO:0080098 name: L-tyrosine:pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + pyruvate = 4-hydroxyphenylpyruvate + L-alanine." [PMID:18394996] xref: EC:2.6.1.58 xref: MetaCyc:RXN3O-4157 is_a: GO:0070547 ! L-tyrosine aminotransferase activity [Term] id: GO:0080099 name: L-methionine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate." [PMID:18394996] comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.5 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.5). synonym: "L-methionine:alpha-ketoglutarate aminotransferase activity" EXACT [] is_a: GO:0010326 ! methionine-oxo-acid transaminase activity [Term] id: GO:0080100 name: L-glutamine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate." [PMID:18394996] comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.50 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.50). synonym: "L-glutamine:alpha-ketoglutarate aminotransferase activity" EXACT [] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0080101 name: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine." [EC:2.1.1.71, PMID:19366698] is_a: GO:0008170 ! N-methyltransferase activity [Term] id: GO:0080102 name: 3-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the conversion of 3-methylthiopropyl glucosinolate to 3-methylsulfinylpropyl glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0080103 name: 4-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the conversion of 4-methylthiopropyl glucosinolate to 4-methylsulfinylpropyl glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0080104 name: 5-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the conversion of 5-methylthiopropyl glucosinolate to 5-methylsulfinylpropyl glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0080105 name: 6-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the conversion of 6-methylthiopropyl glucosinolate to 6-methylsulfinylpropyl glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0080106 name: 7-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the conversion of 7-methylthiopropyl glucosinolate to 7-methylsulfinylpropyl glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0080107 name: 8-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the conversion of 8-methylthiopropyl glucosinolate to 8-methylsulfinylpropyl glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0080108 name: S-alkylthiohydroximate lyase activity namespace: molecular_function def: "Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate." [PMID:14871316] synonym: "S-alkylthiohydroximate C-S lyase activity" NARROW [] is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0080109 name: indole-3-acetonitrile nitrile hydratase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide." [EC:4.2.1.84, MetaCyc:RXN-7567, PMID:11607511, PMID:12430025] is_a: GO:0018822 ! nitrile hydratase activity [Term] id: GO:0080110 name: sporopollenin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer." [PMID:19218397] synonym: "sporopollenin biosynthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process relationship: part_of GO:0010584 ! pollen exine formation [Term] id: GO:0080111 name: DNA demethylation namespace: biological_process def: "The removal of a methyl group from one or more nucleotides within an DNA molecule." [PMID:17208187] is_a: GO:0035510 ! DNA dealkylation is_a: GO:0040029 ! regulation of gene expression, epigenetic is_a: GO:0070988 ! demethylation [Term] id: GO:0080112 name: seed growth namespace: biological_process def: "The increase in size or mass of a seed. Seed is a propagating organ formed in the reproductive cycle of gymnosperms and angiosperms, derived from the ovule and enclosing an embryo." [GOC:dhl, PO:0009010] is_a: GO:0035265 ! organ growth relationship: part_of GO:0048316 ! seed development [Term] id: GO:0080113 name: regulation of seed growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of the seed of an plant." [PMID:19141706] synonym: "regulation of seed size" EXACT [] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0080050 ! regulation of seed development relationship: regulates GO:0080112 ! seed growth [Term] id: GO:0080114 name: positive regulation of glycine hydroxymethyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1, PMID:19223513] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051347 ! positive regulation of transferase activity [Term] id: GO:0080115 name: myosin XI tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin XI heavy chain." [PMID:18703495] is_a: GO:0032029 ! myosin tail binding [Term] id: GO:0080116 name: glucuronoxylan glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule." [PMID:18980649] is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0080117 name: secondary growth namespace: biological_process def: "Increase in plant girth due to the activity of lateral meristems (vascular and cork cambium)." [PMID:19074290] is_a: GO:0040007 ! growth [Term] id: GO:0080118 name: brassinosteroid sulfotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative and 3'-phosphoadenosine 5'-phosphate." [CHEBI:22921, PMID:10409637, PMID:17039368] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0080119 name: ER body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation of ER (endoplasmic reticulum) body. ER body is a compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:18780803, PMID:19147648] synonym: "endoplasmic reticulum body organization" EXACT [] synonym: "endoplasmic reticulum body organization and biogenesis" RELATED [GOC:mah] synonym: "ER body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0080120 name: CAAX-box protein maturation namespace: biological_process def: "A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase." [PMID:12039957, PMID:17114793, PMID:18641086] synonym: "CAAX-box protein processing" RELATED [] synonym: "farnesylated protein maturation" RELATED [GOC:vw] is_a: GO:0044267 ! cellular protein metabolic process is_a: GO:0051604 ! protein maturation [Term] id: GO:0080121 name: AMP transport namespace: biological_process def: "The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18923018] synonym: "adenosine monophosphate transport" EXACT [] is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport [Term] id: GO:0080122 name: AMP transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other." [PMID:18923018] synonym: "adenosine monophosphate transmembrane transporter activity" EXACT [] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity [Term] id: GO:0080123 name: jasmonate-amino synthetase activity namespace: molecular_function def: "Catalysis of the reaction: jasmonate + an amino acid = an amide-linked jasmonyl-amino acid conjugate. The substrates of this reaction include non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate)." [PMID:15258265, PMID:17291501] synonym: "ja-amino synthetase activity" EXACT [] synonym: "jasmonate-amido synthetase activity" EXACT [] synonym: "jasmonate-amino acid conjugate synthetase activity" EXACT [] synonym: "jasmonate-amino acid synthetase activity" EXACT [] synonym: "jasmonate:amino acid synthetase activity" EXACT [] synonym: "jasmonic acid-amino synthetase activity" EXACT [] synonym: "jasmonyl-amino synthetase activity" EXACT [] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0080124 name: pheophytinase activity namespace: molecular_function def: "Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide." [PMID:19304936] synonym: "pheophytin pheophorbide hydrolase activity" EXACT [] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0080125 name: multicellular structure septum development namespace: biological_process def: "The process whose specific outcome is the progression of the multicellular structure septum over time, from its formation to the mature structure. The multicellular structure septum is the thin partition or membrane that divides a cavity or a mass of tissue." [GOC:dhl] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0080126 name: ovary septum development namespace: biological_process def: "The process whose specific outcome is the progression of the ovary septum over time, from its formation to the mature structure. The ovary septum is the thin partition that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)." [PMID:17855426] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0080125 ! multicellular structure septum development relationship: part_of GO:0035670 ! ovule-producing ovary development [Term] id: GO:0080127 name: fruit septum development namespace: biological_process def: "The process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit." [GOC:dhl, PO:0005008] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009791 ! post-embryonic development is_a: GO:0080125 ! multicellular structure septum development relationship: part_of GO:0010154 ! fruit development [Term] id: GO:0080128 name: anther septum development namespace: biological_process def: "The process whose specific outcome is the progression of the anther septum over time, from its formation to the mature structure. The anther septum is a thin partition or stretch of cells that are present in the anther dehiscence zone." [GOC:dhl, PO:0005010] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0080125 ! multicellular structure septum development relationship: part_of GO:0048653 ! anther development [Term] id: GO:0080129 name: proteasome core complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [PMID:12401807, PMID:17971041] synonym: "20S proteasome assembly" EXACT [] is_a: GO:0043248 ! proteasome assembly [Term] id: GO:0080130 name: L-phenylalanine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate." [GOC:pmn_curators, PMID:18394996] comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.57 and several other EC numbers (See BRENDA:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.57). synonym: "L-phenylalanine:alpha-ketoglutarate aminotransferase activity" EXACT [] xref: MetaCyc:PHEAMINOTRANS-RXN is_a: GO:0070546 ! L-phenylalanine aminotransferase activity [Term] id: GO:0080131 name: hydroxyjasmonate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: a hydroxyjasmonate + phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-bisphosphate." [EC:2.8.2.-, GOC:pmn_curators, MetaCyc:RXN-10451, MetaCyc:RXN-10453, PMID:12637544] synonym: "11-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10453] synonym: "11-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10453] synonym: "11-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10453] synonym: "12-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10451] synonym: "12-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10451] synonym: "12-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10451] synonym: "hydroxyjasmonic acid sulfotransferase activity" EXACT [] synonym: "OHJA sulfotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0080132 name: fatty acid alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain." [PMID:19054355] synonym: "fatty acid 2-hydroxylase" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0080133 name: midchain alkane hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of an alkane to a secondary alcohol." [PMID:17905869] is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0080134 name: regulation of response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0006950 ! response to stress [Term] id: GO:0080135 name: regulation of cellular response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0080134 ! regulation of response to stress relationship: regulates GO:0033554 ! cellular response to stress [Term] id: GO:0080136 name: priming of cellular response to stress namespace: biological_process def: "The process that enables cells to respond in a more rapid and robust manner than nonprimed cells to much lower levels of a stimulus indicating the organism is under stress." [PMID:19318610] synonym: "priming of response to stress" BROAD [] synonym: "priming of stress response" BROAD [] is_a: GO:0080135 ! regulation of cellular response to stress relationship: part_of GO:0033554 ! cellular response to stress [Term] id: GO:0080137 name: DNA-directed RNA polymerase V complex namespace: cellular_component def: "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants. In addition to RNA polymerases I, II, and III, the essential RNA polymerases present in all eukaryotes, plants have two additional nuclear RNA polymerases, Pol IV and Pol V, that play nonredundant roles in siRNA-directed DNA methylation and gene silencing. Pol IV is required for siRNA production and Pol V is required for generating noncoding transcripts at target loci. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol V are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases." [PMID:19110459] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0080138 name: borate uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of borate from the outside of a cell to the inside of the cell across a membrane." [PMID:18603465] synonym: "boron uptake transmembrane transporter activity" RELATED [GOC:curators] is_a: GO:0015563 ! uptake transmembrane transporter activity [Term] id: GO:0080139 name: borate efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of borate from the inside of the cell to the outside of the cell across a membrane." [PMID:18603465] synonym: "boron efflux transmembrane transporter activity" RELATED [GOC:curators] is_a: GO:0015562 ! efflux transmembrane transporter activity is_a: GO:0046715 ! borate transmembrane transporter activity [Term] id: GO:0080140 name: regulation of jasmonic acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid." [GOC:dhl] is_a: GO:0019217 ! regulation of fatty acid metabolic process relationship: regulates GO:0009694 ! jasmonic acid metabolic process [Term] id: GO:0080141 name: regulation of jasmonic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid." [GOC:dhl] is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0080140 ! regulation of jasmonic acid metabolic process relationship: regulates GO:0009695 ! jasmonic acid biosynthetic process [Term] id: GO:0080142 name: regulation of salicylic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid." [GOC:dhl] is_a: GO:0010337 ! regulation of salicylic acid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0009697 ! salicylic acid biosynthetic process [Term] id: GO:0080143 name: regulation of amino acid export namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid export. Amino acid export is the directed movement of amino acids out of a cell or organelle." [PMID:20018597] is_a: GO:0051955 ! regulation of amino acid transport relationship: regulates GO:0032973 ! amino acid export [Term] id: GO:0080144 name: amino acid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of amino acid within an organism or cell." [PMID:19955263] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0080145 name: cysteine homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cysteine within an organism or cell." [PMID:19955263] is_a: GO:0080144 ! amino acid homeostasis [Term] id: GO:0080146 name: L-cysteine desulfhydrase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+." [MetaCyc:LCYSDESULF-RXN, PMID:19955263] xref: EC:4.4.1.1 xref: MetaCyc:LCYSDESULF-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0080147 name: root hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of a root hair cell over time, from its formation to the mature state." [PMID:19675148] is_a: GO:0048468 ! cell development relationship: part_of GO:0048765 ! root hair cell differentiation [Term] id: GO:0080148 name: negative regulation of response to water deprivation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to water deprivation. Response to water deprivation is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [PMID:18835996] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000070 ! regulation of response to water deprivation relationship: negatively_regulates GO:0009414 ! response to water deprivation [Term] id: GO:0080149 name: sucrose induced translational repression namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level." [PMID:19403731] synonym: "negative regulation of translation in response to sucrose" EXACT [] is_a: GO:0032055 ! negative regulation of translation in response to stress [Term] id: GO:0080150 name: S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine." [MetaCyc:RXN-6722, PMID:10852939] synonym: "S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity" EXACT [] xref: MetaCyc:RXN-6722 is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0080151 name: positive regulation of salicylic acid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction." [PMID:20181750] synonym: "positive regulation of salicylic acid mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway relationship: positively_regulates GO:0009863 ! salicylic acid mediated signaling pathway [Term] id: GO:0080152 name: regulation of reductive pentose-phosphate cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductive pentose-phosphate cycle." [PMID:17031544] synonym: "regulation of C3 photosynthesis" NARROW [] synonym: "regulation of Calvin cycle" NARROW [] is_a: GO:0010110 ! regulation of photosynthesis, dark reaction relationship: regulates GO:0019253 ! reductive pentose-phosphate cycle [Term] id: GO:0080153 name: negative regulation of reductive pentose-phosphate cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle." [PMID:17031544, PMID:20399532] synonym: "negative regulation of C3 photosynthesis" NARROW [] synonym: "negative regulation of Calvin cycle" NARROW [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0080152 ! regulation of reductive pentose-phosphate cycle relationship: negatively_regulates GO:0019253 ! reductive pentose-phosphate cycle [Term] id: GO:0080154 name: regulation of fertilization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994] is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0009566 ! fertilization [Term] id: GO:0080155 name: regulation of double fertilization forming a zygote and endosperm namespace: biological_process def: "Any process that modulates the rate, frequency or extent of double fertilization forming a zygote and endosperm. Double fertilization forming a zygote and endosperm is a type of fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:DHL, PMID:20478994] is_a: GO:0080154 ! regulation of fertilization relationship: regulates GO:0009567 ! double fertilization forming a zygote and endosperm [Term] id: GO:0080156 name: mitochondrial mRNA modification namespace: biological_process def: "The covalent alteration within the mitochondrion of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically." [PMID:20566637] synonym: "mitochondrial mRNA editing" NARROW [] synonym: "mitochondrial RNA editing" BROAD [] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0016556 ! mRNA modification [Term] id: GO:0080157 name: regulation of plant-type cell wall organization or biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving plant-type cell wall organization or biogenesis. Plant-type cell wall organization or biogenesis is a process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [PMID:20530756] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0071669 ! plant-type cell wall organization or biogenesis [Term] id: GO:0080158 name: chloroplast ribulose bisphosphate carboxylase complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a chloroplast ribulose bisphosphate carboxylase (RubisCO) complex. Includes the synthesis of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex." [PMID:20561259] is_a: GO:0070271 ! protein complex biogenesis is_a: GO:0071843 ! cellular component biogenesis at cellular level [Term] id: GO:0080159 name: zygote elongation namespace: biological_process def: "The process in which the zygote irreversibly increases in size in one dimension after fertilization. An example of such a process is found in Arabidopsis thaliana." [GOC:tb] is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0080160 name: selenate transport namespace: biological_process def: "The directed movement of selenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18761637] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0080161 name: auxin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of auxins from one side of the membrane to the other. Auxins are plant hormones that regulate aspects of plant growth." [PMID:19506555] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0080162 name: intracellular auxin transport namespace: biological_process def: "The directed movement of auxins within a cell. Auxins are a group of plant hormones that regulates aspects of plant growth." [PMID:19506555] is_a: GO:0046907 ! intracellular transport is_a: GO:0060918 ! auxin transport [Term] id: GO:0080163 name: regulation of protein serine/threonine phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142] synonym: "regulation of protein phosphatase type 2c activity" NARROW [] is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity [Term] id: GO:0080164 name: regulation of nitric oxide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:DHL] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: regulates GO:0046209 ! nitric oxide metabolic process [Term] id: GO:0080165 name: callose deposition in phloem sieve plate namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, phloem sieve plate. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [PMID:19470642] is_a: GO:0052545 ! callose localization [Term] id: GO:0080166 name: stomium development namespace: biological_process def: "The process whose specific outcome is the progression of the stomium over time, from its formation to the mature structure. A stomium is a fissure or pore in the anther lobe through which the pollen is released." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048653 ! anther development [Term] id: GO:0080167 name: response to karrikin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants)." [PMID:20351290] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0080168 name: abscisic acid transport namespace: biological_process def: "The directed movement of abscisic acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [PMID:20133881] is_a: GO:0046865 ! terpenoid transport [Term] id: GO:0080169 name: cellular response to boron-containing substance deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of boron obtained from boron-containing substances." [PMID:20059736] synonym: "cellular response to boron deprivation" EXACT [GOC:curators] synonym: "cellular response to boron starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0080029 ! cellular response to boron-containing substance levels [Term] id: GO:0080170 name: hydrogen peroxide transmembrane transport namespace: biological_process def: "The process in which hydrogen peroxide is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute." [GOC:tb] is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0080171 name: lytic vacuole organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole." [PMID:20729380] synonym: "lytic vacuolar assembly" NARROW [] synonym: "lytic vacuole biogenesis" RELATED [] synonym: "lytic vacuole organisation" EXACT [] synonym: "lytic vacuole organization and biogenesis" RELATED [] is_a: GO:0007033 ! vacuole organization [Term] id: GO:0080172 name: petal epidermis patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the cells in the petal epidermis." [GOC:tb] is_a: GO:0003002 ! regionalization [Term] id: GO:0080173 name: Male-female gamete recognition during double fertilization namespace: biological_process def: "The initial contact step made between the male gamete and the female gamete during double fertilization. An example can be found in Arabidopsis thaliana." [PMID:21123745] synonym: "gamete recognition" BROAD [] synonym: "male-female gamete recognition" EXACT [] is_a: GO:0009988 ! cell-cell recognition is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0009567 ! double fertilization forming a zygote and endosperm [Term] id: GO:0080174 name: sulfate homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of the polyatomic anion sulfate." [GOC:tb] is_a: GO:0055081 ! anion homeostasis [Term] id: GO:0080175 name: phragmoplast microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in phragmoplast, a plant cell specific structure that forms during late cytokinesis. Phragmoplast serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells." [PMID:19383896] synonym: "phragmoplast microtubule cytoskeleton organization" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0080176 name: xyloglucan 1,6-alpha-xylosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus." [PMID:20801759] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0080177 name: plastoglobule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [PMID:20813909] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0009658 ! chloroplast organization [Term] id: GO:0080178 name: 5-carbamoylmethyluridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 5-carbamoylmethyluridine." [GOC:tb] is_a: GO:0046108 ! uridine metabolic process [Term] id: GO:0080179 name: 1-methylguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-methylguanosine." [GOC:tb] is_a: GO:0046114 ! guanosine biosynthetic process [Term] id: GO:0080180 name: 2-methylguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-methylguanosine." [GOC:tb] is_a: GO:0046114 ! guanosine biosynthetic process [Term] id: GO:0085000 name: modification by symbiont of host morphology or physiology via protein secreted by type V secretion system namespace: biological_process def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type V secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0044048 ! interaction with host via protein secreted by type V secretion system is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance [Term] id: GO:0085001 name: formation by symbiont of stylet for nutrient acquisition from host namespace: biological_process def: "The assembly by a symbiont of a stylet, a hollow protrusible spear-like structure projected into the host cell for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host [Term] id: GO:0085002 name: interaction with host mediated by secreted substance released by symbiont from symbiotic structure namespace: biological_process def: "An interaction with the host organism mediated by a symbiont secreted substance released by specialized structures generated in either organisms as a result of the symbiotic interaction. The term host is used for the larger (macro) of the two members of a symbiosis." [GOC:pamgo_curators] comment: This term can be used for annotation of structures like the parasitophorous vacuole which are symbiont induced but entirely host-derived, as well as structures like the stylet which are entirely symbiont-derived. is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction [Term] id: GO:0085003 name: interaction with host via secreted substance released from stylet namespace: biological_process def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the stylet, a hollow protrusible spear-like structure in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure [Term] id: GO:0085004 name: interaction with host via secreted substance released from haustorium namespace: biological_process def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the haustorium, a projection from a cell or tissue that penetrates the host's cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure [Term] id: GO:0085005 name: interaction with host via secreted substance released from invasive hyphae namespace: biological_process def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via invasive hyphae. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure [Term] id: GO:0085006 name: interaction with host mediated by symbiont secreted substance released from symbiont-containing vacuole namespace: biological_process def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via a symbiont-containing vacuole, a specialized sac within the host in which the symbiont resides. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "interaction with host mediated by symbiont secreted substance released from parasitophorous vacuole" EXACT [] is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure [Term] id: GO:0085007 name: interaction with host via secreted substance released from rhoptry namespace: biological_process def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the rhoptry, a large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure [Term] id: GO:0085008 name: interaction with host via secreted substance released from microneme namespace: biological_process def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the microneme, a small, elongated secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure [Term] id: GO:0085009 name: interaction with host mediated by symbiont secreted substance released from Maurer's cleft namespace: biological_process def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via Maurer's cleft. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "interaction with host mediated by symbiont secreted substance released from Maurers cleft" EXACT [] is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure [Term] id: GO:0085010 name: interaction with host mediated by secreted substance entering host via endocytosis namespace: biological_process def: "An interaction with the host organism mediated by a secreted substance from the symbiont entering host cells via endocytosis of the substance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction [Term] id: GO:0085011 name: interaction with host via protein secreted by Sec complex namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Sec complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "interaction with host via protein secreted by Sec secretion system" EXACT [] is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction [Term] id: GO:0085012 name: interaction with host via protein secreted by Tat complex namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Tat complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "interaction with host via protein secreted by Tat secretion system" EXACT [] is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction [Term] id: GO:0085013 name: interaction with host via protein secreted by type VII secretion system namespace: biological_process def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type VII secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction [Term] id: GO:0085014 name: dormancy entry of symbiont in host namespace: biological_process def: "Entry into a dormant state of the symbiont within the host organism." [GOC:jl] is_a: GO:0022611 ! dormancy process is_a: GO:0044114 ! development of symbiont in host [Term] id: GO:0085015 name: dormancy maintenance of symbiont in host namespace: biological_process def: "Any process in which a dormant state is maintained by the symbiont within the host organism." [GOC:jl] synonym: "non-replicating persistence" EXACT [] synonym: "NRP" EXACT [] is_a: GO:0022611 ! dormancy process is_a: GO:0044114 ! development of symbiont in host [Term] id: GO:0085016 name: dormancy exit of symbiont in host namespace: biological_process def: "Exit from dormant state, also known as resuscitation, of the symbiont within the host organism." [GOC:jl] synonym: "resuscitation of symbiont" EXACT [] is_a: GO:0022611 ! dormancy process is_a: GO:0044114 ! development of symbiont in host [Term] id: GO:0085017 name: symbiont entry into host cell forming a symbiont-containing vacuole namespace: biological_process def: "The invasion by a symbiont of a cell of its host organism, forming a vacuole in which the parasite resides. The vacuole membrane is formed from lipids and proteins derived from both host and symbiont. Begins when the symbiont attaches on to the host cell membrane which invaginates and deepens as the symbiont enters, and ends when the host cell membrane closes behind the newly-formed vacuole." [GOC:jl, PMID:18665841, PMID:8690024, PMID:9580555] synonym: "symbiont entry into host cell forming a parasitophorous vacuole" EXACT [] synonym: "symbiont entry into host cell forming a pathogen-containing vacuole" EXACT [] is_a: GO:0030260 ! entry into host cell [Term] id: GO:0085018 name: maintenance of symbiont-containing vacuole via substance secreted by host namespace: biological_process def: "The process in which a host organism maintains the structure and function of a symbiont-containing vacuole, mediated by a substance secreted by the host. The symbiont-containing vacuole is a membrane-bounded vacuole within a host cell in which a symbiont organism resides." [GOC:jl] synonym: "maintenance of parasitophorous vacuole via substance secreted by host" EXACT [] synonym: "maintenance of pathogen-containing vacuole via substance secreted by host" EXACT [] is_a: GO:0052182 ! modification by host of symbiont morphology or physiology via secreted substance [Term] id: GO:0085019 name: formation by symbiont of a tubovesicular network for nutrient acquisition from host namespace: biological_process def: "The assembly of a symbiont-induced complex organelle that comprises of multiple protein and lipid domains for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "formation of a symbiont- induced tubovesicular network for nutrient acquisition from host" EXACT [] is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host [Term] id: GO:0085020 name: protein K6-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp] synonym: "protein K6-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination [Term] id: GO:0085021 name: modification by symbiont of host morphology or physiology via protein secreted by type I secretion system namespace: biological_process def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type I secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0044047 ! interaction with host via protein secreted by type I secretion system is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance [Term] id: GO:0085022 name: modification by symbiont of host morphology or physiology via protein secreted by type VI secretion system namespace: biological_process def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VI secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0044049 ! interaction with host via protein secreted by type VI secretion system is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance [Term] id: GO:0085023 name: modification by symbiont of host morphology or physiology via protein secreted by type VII secretion system namespace: biological_process def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VII secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] subset: gosubset_prok is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance is_a: GO:0085013 ! interaction with host via protein secreted by type VII secretion system [Term] id: GO:0085024 name: modification by symbiont of host morphology or physiology via protein secreted by Sec complex namespace: biological_process def: "The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Sec complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Sec secretion system" EXACT [] is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance is_a: GO:0085011 ! interaction with host via protein secreted by Sec complex [Term] id: GO:0085025 name: modification by symbiont of host morphology or physiology via protein secreted by Tat complex namespace: biological_process def: "The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Tat complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Tat secretion system" EXACT [] is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance is_a: GO:0085012 ! interaction with host via protein secreted by Tat complex [Term] id: GO:0085026 name: tubovesicular membrane network namespace: cellular_component def: "A complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains." [GOC:pamgo_curators] synonym: "TVM network" EXACT [] synonym: "TVN" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part is_a: GO:0043264 ! extracellular non-membrane-bounded organelle [Term] id: GO:0085027 name: entry into host via enzymatic degradation of host anatomical structure namespace: biological_process def: "Penetration by symbiont of a host anatomical structure which provides a barrier to symbiont entry, mediated by symbiont degradative enzymes." [GOC:pamgo_curators] is_a: GO:0044411 ! entry into host through host barriers [Term] id: GO:0085028 name: entry into host via enzymatic degradation of host cuticle namespace: biological_process def: "Penetration by symbiont of host physical barriers, mediated by symbiont degradative enzymes." [GOC:pamgo_curators] is_a: GO:0085027 ! entry into host via enzymatic degradation of host anatomical structure [Term] id: GO:0085029 name: extracellular matrix assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl] is_a: GO:0030198 ! extracellular matrix organization is_a: GO:0071844 ! cellular component assembly at cellular level [Term] id: GO:0085030 name: mutualism namespace: biological_process def: "An interaction between two organisms living together in more or less intimate association in a relationship in which both organisms benefit from each other." [GOC:pamgo_curators] is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0085031 name: commensalism namespace: biological_process def: "An interaction between two organisms living together in more or less intimate association in a relationship in which one benefits and the other is unaffected." [GOC:pamgo_curators] is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0085032 name: modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "modulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT [] is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB cascade is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0085033 name: positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "activation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "induction by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT [] synonym: "positive regulation by symbiont of nuclear factor kappa-light-chain-enhancer of activated B cells mediated signal transduction pathway" EXACT [] synonym: "stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] is_a: GO:0043123 ! positive regulation of I-kappaB kinase/NF-kappaB cascade is_a: GO:0085032 ! modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0085034 name: negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0043124 ! negative regulation of I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0085035 name: haustorium namespace: cellular_component def: "A projection from a cell or tissue that penetrates the host's cell wall and invaginates the host cell membrane." [GOC:pamgo_curators] comment: See also: extrahaustorial matrix ; GO:0085036 and extrahaustorial membrane ; GO:0085037. is_a: GO:0042995 ! cell projection [Term] id: GO:0085036 name: extrahaustorial matrix namespace: cellular_component def: "The space between the symbiont plasma membrane and the extrahaustorial membrane of the host." [GOC:pamgo_curators] comment: See also: haustorium ; GO:0085035 and extrahaustorial membrane ; GO:0085037. is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0043655 ! extracellular space of host [Term] id: GO:0085037 name: extrahaustorial membrane namespace: cellular_component def: "The membrane surrounding the symbiont haustorium during symbiosis, derived from the host plasma membrane." [GOC:pamgo_curators] comment: See also: haustorium ; GO:0085035 and extrahaustorial matrix ; GO:0085036. is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0020002 ! host cell plasma membrane [Term] id: GO:0085039 name: extra-invasive hyphal membrane namespace: cellular_component def: "A host-derived membrane surrounding the symbiont invasive hypha during symbiosis." [GOC:pamgo_curators] comment: See also: extra-invasive hyphal space ; GO:0085040. is_a: GO:0033644 ! host cell membrane [Term] id: GO:0085040 name: extra-invasive hyphal space namespace: cellular_component def: "The space between the symbiont plasma membrane and the extra-invasive hyphal membrane." [GOC:pamgo_curators] comment: See also: 'extra-invasive hyphal membrane ; GO:0085039'. is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0043655 ! extracellular space of host [Term] id: GO:0085041 name: arbuscule namespace: cellular_component def: "Highly branched symbiont haustoria within host root cortex cells, responsible for nutrient exchange." [GOC:pamgo_curators] comment: See also: periarbuscular membrane ; GO:0085042. is_a: GO:0085035 ! haustorium [Term] id: GO:0085042 name: periarbuscular membrane namespace: cellular_component def: "A host-derived membrane surrounding the symbiont arbuscule during symbiosis." [GOC:pamgo_curators] comment: See also: arbuscule ; GO:0085041. is_a: GO:0033644 ! host cell membrane [Term] id: GO:0085044 name: disassembly by symbiont of host cuticle namespace: biological_process def: "The process in which a symbiont organism effects a breakdown of the host organism cuticle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] synonym: "catabolism of host cuticle" EXACT [] synonym: "degradation of host cuticle" RELATED [] is_a: GO:0052111 ! modification by symbiont of host structure [Term] id: GO:0090001 name: replication fork arrest at tRNA locus namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit." [GOC:dph, GOC:tb] is_a: GO:0043111 ! replication fork arrest [Term] id: GO:0090002 name: establishment of protein localization in plasma membrane namespace: biological_process def: "The directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb] synonym: "establishment of protein localisation in plasma membrane" EXACT [GOC:mah] is_a: GO:0090150 ! establishment of protein localization in membrane relationship: part_of GO:0072659 ! protein localization in plasma membrane [Term] id: GO:0090003 name: regulation of establishment of protein localization in plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb] synonym: "regulation of establishment of protein localisation in plasma membrane" EXACT [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0070201 ! regulation of establishment of protein localization relationship: regulates GO:0090002 ! establishment of protein localization in plasma membrane [Term] id: GO:0090004 name: positive regulation of establishment of protein localization in plasma membrane namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb] synonym: "positive regulation of establishment of protein localisation in plasma membrane" EXACT [GOC:mah] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0090003 ! regulation of establishment of protein localization in plasma membrane relationship: positively_regulates GO:0090002 ! establishment of protein localization in plasma membrane [Term] id: GO:0090005 name: negative regulation of establishment of protein localization in plasma membrane namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb] synonym: "negative regulation of establishment of protein localisation in plasma membrane" EXACT [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0090003 ! regulation of establishment of protein localization in plasma membrane relationship: negatively_regulates GO:0090002 ! establishment of protein localization in plasma membrane [Term] id: GO:0090006 name: regulation of linear element assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:tb] synonym: "regulation of linear element assembly" RELATED [GOC:dph] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0060631 ! regulation of meiosis I relationship: regulates GO:0030999 ! linear element assembly [Term] id: GO:0090007 name: regulation of mitotic anaphase namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic anaphase, a cell cycle process comprising the steps by which a cell progresses through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [GOC:tb] is_a: GO:0007088 ! regulation of mitosis relationship: regulates GO:0000090 ! mitotic anaphase [Term] id: GO:0090008 name: hypoblast development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast and gives rise to extraembryonic endoderm." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0090009 name: primitive streak formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001702 ! gastrulation with mouth forming second relationship: part_of GO:0009948 ! anterior/posterior axis specification [Term] id: GO:0090010 name: transforming growth factor beta receptor signaling pathway involved in primitive streak formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands contributing to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "TGFbeta signaling pathway involved in primitive streak formation" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: part_of GO:0090009 ! primitive streak formation [Term] id: GO:0090011 name: Wnt receptor signaling pathway involved in primitive streak formation namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contribute to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "Wnt receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0090009 ! primitive streak formation [Term] id: GO:0090012 name: negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "negative regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0090013 ! regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation relationship: negatively_regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation [Term] id: GO:0090013 name: regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway relationship: regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation [Term] id: GO:0090014 name: leaflet formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060794 ! leaflet morphogenesis [Term] id: GO:0090015 name: positive regulation of leaflet formation by auxin mediated signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "positive regulation of leaflet formation by auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009734 ! auxin mediated signaling pathway is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0090016 ! regulation of leaflet formation relationship: positively_regulates GO:0090014 ! leaflet formation [Term] id: GO:0090016 name: regulation of leaflet formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leaflet formation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:2000024 ! regulation of leaf development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0090014 ! leaflet formation [Term] id: GO:0090017 name: anterior neural plate formation namespace: biological_process def: "The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021990 ! neural plate formation [Term] id: GO:0090018 name: posterior neural plate formation namespace: biological_process def: "The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021990 ! neural plate formation [Term] id: GO:0090019 name: regulation of transcription involved in anterior neural plate formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the anterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0090017 ! anterior neural plate formation [Term] id: GO:0090020 name: regulation of transcription involved in posterior neural plate formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the posterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0090018 ! posterior neural plate formation [Term] id: GO:0090021 name: positive regulation of posterior neural plate formation by Wnt receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "positive regulation of posterior neural plate formation by Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000027 ! regulation of organ morphogenesis relationship: positively_regulates GO:0090018 ! posterior neural plate formation [Term] id: GO:0090022 name: regulation of neutrophil chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis relationship: regulates GO:0030593 ! neutrophil chemotaxis [Term] id: GO:0090023 name: positive regulation of neutrophil chemotaxis namespace: biological_process def: "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0090022 ! regulation of neutrophil chemotaxis relationship: positively_regulates GO:0030593 ! neutrophil chemotaxis [Term] id: GO:0090024 name: negative regulation of neutrophil chemotaxis namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0090022 ! regulation of neutrophil chemotaxis relationship: negatively_regulates GO:0030593 ! neutrophil chemotaxis [Term] id: GO:0090025 name: regulation of monocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis relationship: regulates GO:0002548 ! monocyte chemotaxis [Term] id: GO:0090026 name: positive regulation of monocyte chemotaxis namespace: biological_process def: "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0090025 ! regulation of monocyte chemotaxis relationship: positively_regulates GO:0002548 ! monocyte chemotaxis [Term] id: GO:0090027 name: negative regulation of monocyte chemotaxis namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0090025 ! regulation of monocyte chemotaxis relationship: negatively_regulates GO:0002548 ! monocyte chemotaxis [Term] id: GO:0090028 name: positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0060239 ! positive regulation of signal transduction involved in conjugation with cellular fusion relationship: positively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion [Term] id: GO:0090029 name: negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:0060240 ! negative regulation of signal transduction involved in conjugation with cellular fusion relationship: negatively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion [Term] id: GO:0090030 name: regulation of steroid hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process [Term] id: GO:0090031 name: positive regulation of steroid hormone biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process [Term] id: GO:0090032 name: negative regulation of steroid hormone biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process [Term] id: GO:0090033 name: positive regulation of filamentous growth namespace: biological_process def: "Any process that increases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb] is_a: GO:0010570 ! regulation of filamentous growth is_a: GO:0045927 ! positive regulation of growth relationship: positively_regulates GO:0030447 ! filamentous growth [Term] id: GO:0090034 name: regulation of cellular chaperone-mediated protein complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cellular chaperone-mediated protein complex assembly. Cellular chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0034619 ! cellular chaperone-mediated protein complex assembly [Term] id: GO:0090035 name: positive regulation of cellular chaperone-mediated protein complex assembly namespace: biological_process def: "Any process that increases the frequency, rate, or extent of cellular chaperone-mediated protein complex assembly. Cellular chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0090034 ! regulation of cellular chaperone-mediated protein complex assembly relationship: positively_regulates GO:0034619 ! cellular chaperone-mediated protein complex assembly [Term] id: GO:0090036 name: regulation of protein kinase C signaling cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] synonym: "regulation of protein kinase C signalling cascade" EXACT [GOC:mah] is_a: GO:0010627 ! regulation of intracellular protein kinase cascade relationship: regulates GO:0070528 ! protein kinase C signaling cascade [Term] id: GO:0090037 name: positive regulation of protein kinase C signaling cascade namespace: biological_process def: "Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] synonym: "positive regulation of protein kinase C signalling cascade" EXACT [GOC:mah] is_a: GO:0010740 ! positive regulation of intracellular protein kinase cascade is_a: GO:0090036 ! regulation of protein kinase C signaling cascade relationship: positively_regulates GO:0070528 ! protein kinase C signaling cascade [Term] id: GO:0090038 name: negative regulation of protein kinase C signaling cascade namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] synonym: "negative regulation of protein kinase C signalling cascade" EXACT [GOC:mah] is_a: GO:0010741 ! negative regulation of intracellular protein kinase cascade is_a: GO:0090036 ! regulation of protein kinase C signaling cascade relationship: negatively_regulates GO:0070528 ! protein kinase C signaling cascade [Term] id: GO:0090042 name: tubulin deacetylation namespace: biological_process def: "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0006476 ! protein deacetylation [Term] id: GO:0090043 name: regulation of tubulin deacetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0090311 ! regulation of protein deacetylation relationship: regulates GO:0090042 ! tubulin deacetylation [Term] id: GO:0090044 name: positive regulation of tubulin deacetylation namespace: biological_process def: "Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0090043 ! regulation of tubulin deacetylation is_a: GO:0090312 ! positive regulation of protein deacetylation relationship: positively_regulates GO:0090042 ! tubulin deacetylation [Term] id: GO:0090045 name: positive regulation of deacetylase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0090046 name: regulation of transcription regulator activity namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl] comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term. is_obsolete: true [Term] id: GO:0090047 name: positive regulation of transcription regulator activity namespace: biological_process def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl] comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term. is_obsolete: true [Term] id: GO:0090048 name: negative regulation of transcription regulator activity namespace: biological_process def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl] comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term. is_obsolete: true [Term] id: GO:0090049 name: regulation of cell migration involved in sprouting angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration is_a: GO:0045765 ! regulation of angiogenesis relationship: regulates GO:0002042 ! cell migration involved in sprouting angiogenesis [Term] id: GO:0090050 name: positive regulation of cell migration involved in sprouting angiogenesis namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0043536 ! positive regulation of blood vessel endothelial cell migration is_a: GO:0045766 ! positive regulation of angiogenesis is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis relationship: positively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis [Term] id: GO:0090051 name: negative regulation of cell migration involved in sprouting angiogenesis namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0016525 ! negative regulation of angiogenesis is_a: GO:0043537 ! negative regulation of blood vessel endothelial cell migration is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis relationship: negatively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis [Term] id: GO:0090052 name: regulation of chromatin silencing at centromere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb] is_a: GO:0031935 ! regulation of chromatin silencing relationship: regulates GO:0030702 ! chromatin silencing at centromere [Term] id: GO:0090053 name: positive regulation of chromatin silencing at centromere namespace: biological_process def: "Any process that increases the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb] is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0090052 ! regulation of chromatin silencing at centromere relationship: positively_regulates GO:0030702 ! chromatin silencing at centromere [Term] id: GO:0090054 name: regulation of chromatin silencing at silent mating-type cassette namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb] is_a: GO:0031935 ! regulation of chromatin silencing relationship: regulates GO:0030466 ! chromatin silencing at silent mating-type cassette [Term] id: GO:0090055 name: positive regulation of chromatin silencing at silent mating-type cassette namespace: biological_process def: "Any process that increases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb] is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0090054 ! regulation of chromatin silencing at silent mating-type cassette relationship: positively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette [Term] id: GO:0090056 name: regulation of chlorophyll metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll." [GOC:dph, GOC:tb] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process relationship: regulates GO:0015994 ! chlorophyll metabolic process [Term] id: GO:0090057 name: root radial pattern formation namespace: biological_process def: "The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009956 ! radial pattern formation relationship: part_of GO:0048364 ! root development [Term] id: GO:0090058 name: metaxylem development namespace: biological_process def: "The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0010089 ! xylem development [Term] id: GO:0090059 name: protoxylem development namespace: biological_process def: "The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0010089 ! xylem development [Term] id: GO:0090060 name: regulation of metaxylem development namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0090058 ! metaxylem development [Term] id: GO:0090062 name: regulation of trehalose metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process relationship: regulates GO:0005991 ! trehalose metabolic process [Term] id: GO:0090063 name: positive regulation of microtubule nucleation namespace: biological_process def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0007020 ! microtubule nucleation [Term] id: GO:0090064 name: activation of microtubule nucleation namespace: biological_process def: "Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0090063 ! positive regulation of microtubule nucleation [Term] id: GO:0090065 name: regulation of production of siRNA involved in RNA interference namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of RNA interference, production of siRNA" EXACT [GOC:mah] is_a: GO:0060147 ! regulation of posttranscriptional gene silencing is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA relationship: regulates GO:0030422 ! production of siRNA involved in RNA interference [Term] id: GO:0090066 name: regulation of anatomical structure size namespace: biological_process def: "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0090067 name: regulation of thalamus size namespace: biological_process def: "Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus." [GOC:dph, GOC:tb] is_a: GO:0090066 ! regulation of anatomical structure size [Term] id: GO:0090068 name: positive regulation of cell cycle process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0022402 ! cell cycle process [Term] id: GO:0090069 name: regulation of ribosome biogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0042254 ! ribosome biogenesis [Term] id: GO:0090070 name: positive regulation of ribosome biogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0090069 ! regulation of ribosome biogenesis relationship: positively_regulates GO:0042254 ! ribosome biogenesis [Term] id: GO:0090071 name: negative regulation of ribosome biogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0090069 ! regulation of ribosome biogenesis relationship: negatively_regulates GO:0042254 ! ribosome biogenesis [Term] id: GO:0090072 name: positive regulation of sodium ion transport via voltage-gated sodium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sodium ions via the activity of voltage-gated sodium channels." [GOC:dph, GOC:tb] is_a: GO:0010765 ! positive regulation of sodium ion transport [Term] id: GO:0090073 name: positive regulation of protein homodimerization activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:0043496 ! regulation of protein homodimerization activity [Term] id: GO:0090074 name: negative regulation of protein homodimerization activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:0043496 ! regulation of protein homodimerization activity [Term] id: GO:0090075 name: relaxation of muscle namespace: biological_process def: "A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain." [GOC:rl, PMID:19996365] is_a: GO:0003012 ! muscle system process [Term] id: GO:0090076 name: relaxation of skeletal muscle namespace: biological_process def: "A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases." [GOC:rl] is_a: GO:0090075 ! relaxation of muscle [Term] id: GO:0090077 name: foam cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0090078 name: smooth muscle derived foam cell differentiation namespace: biological_process def: "The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0090077 ! foam cell differentiation [Term] id: GO:0090079 name: translation regulator activity, nucleic acid binding namespace: molecular_function def: "Any nucleic acid binding activity involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:dph, GOC:tb] is_a: GO:0003676 ! nucleic acid binding is_a: GO:0045182 ! translation regulator activity [Term] id: GO:0090080 name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade." [GOC:dph, GOC:tb] synonym: "positive regulation of MAPKKK cascade by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0043410 ! positive regulation of MAPKKK cascade [Term] id: GO:0090081 name: regulation of heart induction by regulation of canonical Wnt receptor signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of canonical Wnt receptor signaling pathway that regulates heart induction. Canonical Wnt receptor signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart] synonym: "regulation of heart induction by regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0003307 ! regulation of Wnt receptor signaling pathway involved in heart development is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0060828 ! regulation of canonical Wnt receptor signaling pathway is_a: GO:0090381 ! regulation of heart induction relationship: regulates GO:0003136 ! negative regulation of heart induction by canonical Wnt receptor signaling pathway [Term] id: GO:0090082 name: positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of canonical Wnt receptor signaling pathway that positively regulates heart induction. Canonical Wnt receptor signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart, PMID:16860783] synonym: "positive regulation of heart induction by negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0003308 ! negative regulation of Wnt receptor signaling pathway involved in heart development is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0090081 ! regulation of heart induction by regulation of canonical Wnt receptor signaling pathway is_a: GO:0090090 ! negative regulation of canonical Wnt receptor signaling pathway relationship: negatively_regulates GO:0003136 ! negative regulation of heart induction by canonical Wnt receptor signaling pathway relationship: positively_regulates GO:0003129 ! heart induction [Term] id: GO:0090083 name: regulation of inclusion body assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0070841 ! inclusion body assembly [Term] id: GO:0090084 name: negative regulation of inclusion body assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0090083 ! regulation of inclusion body assembly relationship: negatively_regulates GO:0070841 ! inclusion body assembly [Term] id: GO:0090085 name: regulation of protein deubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0016579 ! protein deubiquitination [Term] id: GO:0090086 name: negative regulation of protein deubiquitination namespace: biological_process def: "Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0090085 ! regulation of protein deubiquitination relationship: negatively_regulates GO:0016579 ! protein deubiquitination [Term] id: GO:0090087 name: regulation of peptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0015833 ! peptide transport [Term] id: GO:0090088 name: regulation of oligopeptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:dph, GOC:tb] is_a: GO:0090087 ! regulation of peptide transport relationship: regulates GO:0006857 ! oligopeptide transport [Term] id: GO:0090089 name: regulation of dipeptide transport namespace: biological_process def: "Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0090088 ! regulation of oligopeptide transport relationship: regulates GO:0042938 ! dipeptide transport [Term] id: GO:0090090 name: negative regulation of canonical Wnt receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] synonym: "negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway is_a: GO:0060828 ! regulation of canonical Wnt receptor signaling pathway relationship: negatively_regulates GO:0060070 ! canonical Wnt receptor signaling pathway [Term] id: GO:0090091 name: positive regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0022617 ! extracellular matrix disassembly [Term] id: GO:0090092 name: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] synonym: "regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0090093 name: regulation of fungal-type cell wall beta-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:dph, GOC:tb] is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis relationship: regulates GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process [Term] id: GO:0090094 name: metanephric cap mesenchymal cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, PMID:19161241] is_a: GO:0010463 ! mesenchymal cell proliferation is_a: GO:0072203 ! cell proliferation involved in metanephros development relationship: part_of GO:0072186 ! metanephric cap morphogenesis [Term] id: GO:0090095 name: regulation of metanephric cap mesenchymal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation is_a: GO:0072215 ! regulation of metanephros development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development [Term] id: GO:0090096 name: positive regulation of metanephric cap mesenchymal cell proliferation namespace: biological_process def: "Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0090095 ! regulation of metanephric cap mesenchymal cell proliferation is_a: GO:0090184 ! positive regulation of kidney development relationship: positively_regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development [Term] id: GO:0090097 name: regulation of decapentaplegic receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the decapentaplegic receptor signaling pathway. The decapentaplegic receptor signaling pathway is the series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:dph, GOC:tb] synonym: "regulation of decapentaplegic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0008101 ! decapentaplegic receptor signaling pathway [Term] id: GO:0090098 name: positive regulation of decapentaplegic receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the decapentaplegic receptor signaling pathway. The decapentaplegic receptor signaling pathway is the series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:dph, GOC:tb] synonym: "positive regulation of decapentaplegic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0090097 ! regulation of decapentaplegic receptor signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0008101 ! decapentaplegic receptor signaling pathway [Term] id: GO:0090099 name: negative regulation of decapentaplegic receptor signaling pathway namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the decapentaplegic receptor signaling pathway. The decapentaplegic receptor signaling pathway is the series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:dph, GOC:tb] synonym: "negative regulation of decapentaplegic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0090097 ! regulation of decapentaplegic receptor signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0008101 ! decapentaplegic receptor signaling pathway [Term] id: GO:0090100 name: positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] synonym: "positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0090101 name: negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] synonym: "negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0090102 name: cochlea development namespace: biological_process def: "The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound." [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048839 ! inner ear development [Term] id: GO:0090103 name: cochlea morphogenesis namespace: biological_process def: "The process in which the cochlea is generated and organized." [GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0090102 ! cochlea development [Term] id: GO:0090104 name: pancreatic E cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic E cell. A pancreatic E cell is a cell in the pancreas that secretes ghrelin." [GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0090105 name: pancreatic E cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure." [GOC:dph, GOC:tb] is_a: GO:0048468 ! cell development relationship: part_of GO:0090104 ! pancreatic E cell differentiation [Term] id: GO:0090106 name: pancreatic E cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell." [GOC:dph, GOC:tb] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0090104 ! pancreatic E cell differentiation [Term] id: GO:0090107 name: regulation of high-density lipoprotein particle assembly namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0034380 ! high-density lipoprotein particle assembly [Term] id: GO:0090108 name: positive regulation of high-density lipoprotein particle assembly namespace: biological_process def: "Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090107 ! regulation of high-density lipoprotein particle assembly relationship: positively_regulates GO:0034380 ! high-density lipoprotein particle assembly [Term] id: GO:0090109 name: regulation of cell-substrate junction assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0007044 ! cell-substrate junction assembly [Term] id: GO:0090110 name: cargo loading into COPII-coated vesicle namespace: biological_process def: "The formation of a protein complex between the COPII coat proteins and proteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cargo loading into COPII vesicle" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cargo selection into COPII-coated vesicle" EXACT [GOC:vw] synonym: "COPII coat-cargo complex assembly" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0035459 ! cargo loading into vesicle relationship: part_of GO:0090114 ! COPII-coated vesicle budding [Term] id: GO:0090111 name: regulation of COPII vesicle uncoating namespace: biological_process def: "Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0043244 ! regulation of protein complex disassembly is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport relationship: regulates GO:0090112 ! COPII vesicle uncoating [Term] id: GO:0090112 name: COPII vesicle uncoating namespace: biological_process def: "The process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0072319 ! vesicle uncoating relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport [Term] id: GO:0090113 name: regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis namespace: biological_process def: "The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006184 ! GTP catabolic process is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport [Term] id: GO:0090114 name: COPII-coated vesicle budding namespace: biological_process def: "The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "COPII vesicle budding" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] synonym: "ER exit" NARROW [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] synonym: "ER vesicle budding" BROAD [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0006900 ! membrane budding relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport [Term] id: GO:0090115 name: C-5 methylation on cytosine involved in chromatin silencing namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule that contributes to chromatin silencing." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090116 ! C-5 methylation of cytosine relationship: part_of GO:0006346 ! methylation-dependent chromatin silencing [Term] id: GO:0090116 name: C-5 methylation of cytosine namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0090117 name: endosome to lysosome transport of low-density lipoprotein particle namespace: biological_process def: "The directed movement of low-density lipoprotein particle from endosomes to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "endosome to lysosome transport of LDL" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008333 ! endosome to lysosome transport is_a: GO:0090119 ! vesicle-mediated cholesterol transport [Term] id: GO:0090118 name: receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport namespace: biological_process def: "A receptor-mediated endocytosis process that results in the uptake of low-density lipoprotein by cells." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "receptor-mediated endocytosis of LDL" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:dph] is_a: GO:0006898 ! receptor-mediated endocytosis relationship: part_of GO:0032367 ! intracellular cholesterol transport relationship: part_of GO:0034383 ! low-density lipoprotein particle clearance [Term] id: GO:0090119 name: vesicle-mediated cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0090120 name: lysosome to ER cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum." [GOC:mah] synonym: "lysosome to endoplasmic reticulum cholesterol transport" EXACT [GOC:mah] is_a: GO:0090119 ! vesicle-mediated cholesterol transport [Term] id: GO:0090121 name: low-density lipoprotein particle disassembly involved in cholesterol transport namespace: biological_process def: "The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0034623 ! cellular macromolecular complex disassembly is_a: GO:0071829 ! plasma lipoprotein particle disassembly relationship: part_of GO:0034383 ! low-density lipoprotein particle clearance [Term] id: GO:0090122 name: cholesterol ester hydrolysis involved in cholesterol transport namespace: biological_process def: "The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008203 ! cholesterol metabolic process relationship: part_of GO:0090119 ! vesicle-mediated cholesterol transport [Term] id: GO:0090123 name: lysosomal glycocalyx namespace: cellular_component def: "The polysaccharide-based coating on the inner side of a lysosomal membrane that protects it from digestion by lysosomal enzymes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0090124 name: N-4 methylation of cytosine namespace: biological_process def: "The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0090125 name: cell-cell adhesion involved in synapse maturation namespace: biological_process def: "The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "trans-synaptic adhesion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0060074 ! synapse maturation [Term] id: GO:0090126 name: protein complex assembly involved in synapse maturation namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006461 ! protein complex assembly relationship: part_of GO:0060074 ! synapse maturation [Term] id: GO:0090127 name: positive regulation of synapse maturation by synaptic transmission namespace: biological_process def: "Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007268 ! synaptic transmission is_a: GO:0090129 ! positive regulation of synapse maturation [Term] id: GO:0090128 name: regulation of synapse maturation namespace: biological_process def: "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0050807 ! regulation of synapse organization is_a: GO:0051960 ! regulation of nervous system development relationship: regulates GO:0060074 ! synapse maturation [Term] id: GO:0090129 name: positive regulation of synapse maturation namespace: biological_process def: "Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0090128 ! regulation of synapse maturation relationship: positively_regulates GO:0060074 ! synapse maturation [Term] id: GO:0090130 name: tissue migration namespace: biological_process def: "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0090131 name: mesenchyme migration namespace: biological_process def: "The process in which the population of cells that make up a mesenchyme undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090130 ! tissue migration relationship: part_of GO:0072132 ! mesenchyme morphogenesis [Term] id: GO:0090132 name: epithelium migration namespace: biological_process def: "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090130 ! tissue migration [Term] id: GO:0090133 name: mesendoderm migration namespace: biological_process def: "The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090132 ! epithelium migration relationship: part_of GO:0007369 ! gastrulation relationship: part_of GO:0048382 ! mesendoderm development [Term] id: GO:0090134 name: cell migration involved in mesendoderm migration namespace: biological_process def: "The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010631 ! epithelial cell migration is_a: GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0090133 ! mesendoderm migration [Term] id: GO:0090135 name: actin filament branching namespace: biological_process def: "The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007015 ! actin filament organization [Term] id: GO:0090136 name: epithelial cell-cell adhesion namespace: biological_process def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0090137 name: epithelial cell-cell adhesion involved in epithelium migration namespace: biological_process def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090136 ! epithelial cell-cell adhesion relationship: part_of GO:0090132 ! epithelium migration [Term] id: GO:0090138 name: regulation of actin cytoskeleton organization by cell-cell adhesion namespace: biological_process def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0032956 ! regulation of actin cytoskeleton organization [Term] id: GO:0090139 name: mitochondrial DNA packaging namespace: biological_process def: "Any process in which mitochondrial DNA and associated proteins are formed into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006323 ! DNA packaging [Term] id: GO:0090140 name: regulation of mitochondrial fission namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0022603 ! regulation of anatomical structure morphogenesis relationship: regulates GO:0000266 ! mitochondrial fission [Term] id: GO:0090141 name: positive regulation of mitochondrial fission namespace: biological_process def: "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "positive regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0090140 ! regulation of mitochondrial fission relationship: positively_regulates GO:0000266 ! mitochondrial fission [Term] id: GO:0090142 name: mitochondrial chromosome segregation namespace: biological_process def: "The process in which genetic material of the mitochondrion, in the form of the mitochondrial chromosome, is organized and then physically separated and apportioned to two or more sets." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007059 ! chromosome segregation relationship: part_of GO:0000266 ! mitochondrial fission [Term] id: GO:0090143 name: nucleoid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006996 ! organelle organization [Term] id: GO:0090144 name: mitochondrial nucleoid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090143 ! nucleoid organization [Term] id: GO:0090145 name: mitochondrial nucleoid organization involved in mitochondrial fission namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid that contributes to mitochondrial division." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "mitochondrial nucleoid organization involved in mitochondrial fission" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090144 ! mitochondrial nucleoid organization relationship: part_of GO:0000266 ! mitochondrial fission [Term] id: GO:0090146 name: establishment of mitochondrion localization involved in mitochondrial fission namespace: biological_process def: "The directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah] synonym: "mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb] is_a: GO:0051654 ! establishment of mitochondrion localization relationship: part_of GO:0000266 ! mitochondrial fission [Term] id: GO:0090147 name: regulation of establishment of mitochondrion localization involved in mitochondrial fission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah] synonym: "regulation of mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb] is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0090140 ! regulation of mitochondrial fission relationship: regulates GO:0090146 ! establishment of mitochondrion localization involved in mitochondrial fission [Term] id: GO:0090148 name: membrane fission namespace: biological_process def: "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0090149 name: membrane fission involved in mitochondrial fission namespace: biological_process def: "A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090148 ! membrane fission relationship: part_of GO:0000266 ! mitochondrial fission [Term] id: GO:0090150 name: establishment of protein localization in membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah] is_a: GO:0045184 ! establishment of protein localization relationship: part_of GO:0072657 ! protein localization in membrane [Term] id: GO:0090151 name: establishment of protein localization in mitochondrial membrane namespace: biological_process def: "The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in mitochondrial membrane" EXACT [GOC:mah] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0090150 ! establishment of protein localization in membrane [Term] id: GO:0090152 name: establishment of protein localization in mitochondrial membrane involved in mitochondrial fission namespace: biological_process def: "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission" EXACT [GOC:mah] is_a: GO:0090151 ! establishment of protein localization in mitochondrial membrane relationship: part_of GO:0000266 ! mitochondrial fission [Term] id: GO:0090153 name: regulation of sphingolipid biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0030148 ! sphingolipid biosynthetic process [Term] id: GO:0090154 name: positive regulation of sphingolipid biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process relationship: positively_regulates GO:0030148 ! sphingolipid biosynthetic process [Term] id: GO:0090155 name: negative regulation of sphingolipid biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process relationship: negatively_regulates GO:0030148 ! sphingolipid biosynthetic process [Term] id: GO:0090156 name: cellular sphingolipid homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of sphingolipids at the level of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0090157 name: negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis that contributes to the maintenance of an internal equilibrium of sphingolipids at the level of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090155 ! negative regulation of sphingolipid biosynthetic process [Term] id: GO:0090158 name: endoplasmic reticulum membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0007029 ! endoplasmic reticulum organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0090159 name: sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030148 ! sphingolipid biosynthetic process relationship: part_of GO:0090158 ! endoplasmic reticulum membrane organization [Term] id: GO:0090160 name: Golgi to lysosome transport namespace: biological_process def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007041 ! lysosomal transport [Term] id: GO:0090161 name: Golgi ribbon formation namespace: biological_process def: "The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007030 ! Golgi organization [Term] id: GO:0090162 name: establishment of epithelial cell polarity namespace: biological_process def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity [Term] id: GO:0090163 name: establishment of epithelial cell planar polarity namespace: biological_process def: "The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090162 ! establishment of epithelial cell polarity [Term] id: GO:0090164 name: asymmetric Golgi ribbon formation namespace: biological_process def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090161 ! Golgi ribbon formation relationship: part_of GO:0090162 ! establishment of epithelial cell polarity [Term] id: GO:0090165 name: regulation of secretion by asymmetric Golgi ribbon formation namespace: biological_process def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090164 ! asymmetric Golgi ribbon formation [Term] id: GO:0090166 name: Golgi disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007030 ! Golgi organization is_a: GO:0071845 ! cellular component disassembly at cellular level relationship: part_of GO:0048313 ! Golgi inheritance [Term] id: GO:0090167 name: Golgi distribution to daughter cells namespace: biological_process def: "Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007030 ! Golgi organization is_a: GO:0051645 ! Golgi localization relationship: part_of GO:0048313 ! Golgi inheritance [Term] id: GO:0090168 name: Golgi reassembly namespace: biological_process def: "The reformation of the Golgi following its breakdown and partitioning contributing Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007030 ! Golgi organization is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0048313 ! Golgi inheritance [Term] id: GO:0090169 name: regulation of spindle assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of spindle formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0090224 ! regulation of spindle organization relationship: regulates GO:0051225 ! spindle assembly [Term] id: GO:0090170 name: regulation of Golgi inheritance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0048313 ! Golgi inheritance [Term] id: GO:0090171 name: chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002063 ! chondrocyte development [Term] id: GO:0090172 name: microtubule cytoskeleton organization involved in synapsis namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "microtubule organization involved in chromosome pairing" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0090173 name: regulation of synaptonemal complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0060631 ! regulation of meiosis I relationship: regulates GO:0007130 ! synaptonemal complex assembly [Term] id: GO:0090174 name: organelle membrane fusion namespace: biological_process def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006944 ! cellular membrane fusion [Term] id: GO:0090175 name: regulation of establishment of planar polarity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0001736 ! establishment of planar polarity [Term] id: GO:0090176 name: microtubule cytoskeleton organization involved in establishment of planar polarity namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0001736 ! establishment of planar polarity [Term] id: GO:0090177 name: establishment of planar polarity involved in neural tube closure namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042249 ! establishment of planar polarity of embryonic epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0090178 name: regulation of establishment of planar polarity involved in neural tube closure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0090175 ! regulation of establishment of planar polarity relationship: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure [Term] id: GO:0090179 name: planar cell polarity pathway involved in neural tube closure namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure [Term] id: GO:0090180 name: positive regulation of thiamine biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:dph, GOC:tb] synonym: "positive regulation of thiamin biosynthetic process" EXACT [GOC:curators] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046136 ! positive regulation of vitamin metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0070623 ! regulation of thiamine biosynthetic process relationship: positively_regulates GO:0009228 ! thiamine biosynthetic process [Term] id: GO:0090181 name: regulation of cholesterol metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0019218 ! regulation of steroid metabolic process relationship: regulates GO:0008203 ! cholesterol metabolic process [Term] id: GO:0090182 name: regulation of secretion of lysosomal enzymes namespace: biological_process def: "Any process that modulates the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell or group of cells." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0050708 ! regulation of protein secretion relationship: regulates GO:0033299 ! secretion of lysosomal enzymes [Term] id: GO:0090183 name: regulation of kidney development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb] synonym: "regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0001822 ! kidney development [Term] id: GO:0090184 name: positive regulation of kidney development namespace: biological_process def: "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb] synonym: "positive regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090183 ! regulation of kidney development relationship: positively_regulates GO:0001822 ! kidney development [Term] id: GO:0090185 name: negative regulation of kidney development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb] synonym: "negative regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0090183 ! regulation of kidney development relationship: negatively_regulates GO:0001822 ! kidney development [Term] id: GO:0090186 name: regulation of pancreatic juice secretion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051046 ! regulation of secretion relationship: regulates GO:0030157 ! pancreatic juice secretion [Term] id: GO:0090187 name: positive regulation of pancreatic juice secretion namespace: biological_process def: "Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060456 ! positive regulation of digestive system process is_a: GO:0090186 ! regulation of pancreatic juice secretion relationship: positively_regulates GO:0030157 ! pancreatic juice secretion [Term] id: GO:0090188 name: negative regulation of pancreatic juice secretion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060457 ! negative regulation of digestive system process is_a: GO:0090186 ! regulation of pancreatic juice secretion relationship: negatively_regulates GO:0030157 ! pancreatic juice secretion [Term] id: GO:0090189 name: regulation of branching involved in ureteric bud morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:0090183 ! regulation of kidney development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis [Term] id: GO:0090190 name: positive regulation of branching involved in ureteric bud morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis relationship: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis [Term] id: GO:0090191 name: negative regulation of branching involved in ureteric bud morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis relationship: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis [Term] id: GO:0090192 name: regulation of glomerulus development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb] is_a: GO:0090183 ! regulation of kidney development relationship: regulates GO:0032835 ! glomerulus development [Term] id: GO:0090193 name: positive regulation of glomerulus development namespace: biological_process def: "Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb] is_a: GO:0090184 ! positive regulation of kidney development is_a: GO:0090192 ! regulation of glomerulus development relationship: positively_regulates GO:0032835 ! glomerulus development [Term] id: GO:0090194 name: negative regulation of glomerulus development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb] is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:0090192 ! regulation of glomerulus development relationship: negatively_regulates GO:0032835 ! glomerulus development [Term] id: GO:0090195 name: chemokine secretion namespace: biological_process def: "The regulated release of chemokines from a cell or group of cells." [GOC:BHF, GOC:rl] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032602 ! chemokine production [Term] id: GO:0090196 name: regulation of chemokine secretion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell or group of cells." [GOC:BHF, GOC:rl] is_a: GO:0032642 ! regulation of chemokine production is_a: GO:0050707 ! regulation of cytokine secretion relationship: regulates GO:0090195 ! chemokine secretion [Term] id: GO:0090197 name: positive regulation of chemokine secretion namespace: biological_process def: "Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell or group of cells." [GOC:BHF, GOC:rl] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:0090196 ! regulation of chemokine secretion relationship: positively_regulates GO:0090195 ! chemokine secretion [Term] id: GO:0090198 name: negative regulation of chemokine secretion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell or group of cells." [GOC:BHF, GOC:rl] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:0090196 ! regulation of chemokine secretion relationship: negatively_regulates GO:0090195 ! chemokine secretion [Term] id: GO:0090199 name: regulation of release of cytochrome c from mitochondria namespace: biological_process def: "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0001836 ! release of cytochrome c from mitochondria [Term] id: GO:0090200 name: positive regulation of release of cytochrome c from mitochondria namespace: biological_process def: "Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria relationship: positively_regulates GO:0001836 ! release of cytochrome c from mitochondria [Term] id: GO:0090201 name: negative regulation of release of cytochrome c from mitochondria namespace: biological_process def: "Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria relationship: negatively_regulates GO:0001836 ! release of cytochrome c from mitochondria [Term] id: GO:0090202 name: gene looping namespace: biological_process def: "The formation and maintenance of DNA loops that juxtapose sequentially separated regions of RNA polymerase II-transcribed genes." [GOC:dph, GOC:rb, GOC:tb, PMID:19923429, PMID:19933150] is_a: GO:0006325 ! chromatin organization [Term] id: GO:0090203 name: transcriptional activation by promoter-terminator looping namespace: biological_process def: "The formation and maintenance of DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:dph, GOC:rb, GOC:tb] synonym: "transcriptional activation by memory gene loops" RELATED [GOC:dph, GOC:rb, GOC:tb] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0090202 ! gene looping [Term] id: GO:0090204 name: protein localization to nuclear pore namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a nuclear pore." [GOC:dph, GOC:rb, GOC:tb] synonym: "protein localisation to nuclear pore" EXACT [GOC:mah] is_a: GO:0034504 ! protein localization to nucleus [Term] id: GO:0090205 name: positive regulation of cholesterol metabolic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0090181 ! regulation of cholesterol metabolic process relationship: positively_regulates GO:0008203 ! cholesterol metabolic process [Term] id: GO:0090206 name: negative regulation of cholesterol metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0090181 ! regulation of cholesterol metabolic process relationship: negatively_regulates GO:0008203 ! cholesterol metabolic process [Term] id: GO:0090207 name: regulation of triglyceride metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0006641 ! triglyceride metabolic process [Term] id: GO:0090208 name: positive regulation of triglyceride metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0090207 ! regulation of triglyceride metabolic process relationship: positively_regulates GO:0006641 ! triglyceride metabolic process [Term] id: GO:0090209 name: negative regulation of triglyceride metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0090207 ! regulation of triglyceride metabolic process relationship: negatively_regulates GO:0006641 ! triglyceride metabolic process [Term] id: GO:0090210 name: regulation of establishment of blood-brain barrier namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb] synonym: "regulation of establishment of BBB" EXACT [PMID:20080302] is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0060856 ! establishment of blood-brain barrier [Term] id: GO:0090211 name: positive regulation of establishment of blood-brain barrier namespace: biological_process def: "Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of establishment of BBB" EXACT [PMID:20080302] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0090210 ! regulation of establishment of blood-brain barrier relationship: positively_regulates GO:0060856 ! establishment of blood-brain barrier [Term] id: GO:0090212 name: negative regulation of establishment of blood-brain barrier namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb] synonym: "negative regulation of establishment of BBB" EXACT [PMID:20080302] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0090210 ! regulation of establishment of blood-brain barrier relationship: negatively_regulates GO:0060856 ! establishment of blood-brain barrier [Term] id: GO:0090213 name: regulation of radial pattern formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:tb] synonym: "regulation of radial pattern specification " NARROW [GOC:tb] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0009956 ! radial pattern formation [Term] id: GO:0090214 name: spongiotrophoblast layer developmental growth namespace: biological_process def: "The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state." [GOC:dph, GOC:tb] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0060712 ! spongiotrophoblast layer development [Term] id: GO:0090215 name: regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb] is_a: GO:0043550 ! regulation of lipid kinase activity [Term] id: GO:0090216 name: positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb] is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity is_a: GO:0090218 ! positive regulation of lipid kinase activity [Term] id: GO:0090217 name: negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb] is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity is_a: GO:0090219 ! negative regulation of lipid kinase activity [Term] id: GO:0090218 name: positive regulation of lipid kinase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb] is_a: GO:0033674 ! positive regulation of kinase activity is_a: GO:0043550 ! regulation of lipid kinase activity is_a: GO:0045834 ! positive regulation of lipid metabolic process [Term] id: GO:0090219 name: negative regulation of lipid kinase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb] is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:0043550 ! regulation of lipid kinase activity is_a: GO:0045833 ! negative regulation of lipid metabolic process [Term] id: GO:0090220 name: chromosome localization to nuclear envelope involved in synapsis namespace: biological_process def: "The directed movement of a chromosome to the nuclear envelope that contributes to synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:19913287] synonym: "chromosome localisation to nuclear envelope involved in synapsis" EXACT [GOC:mah] is_a: GO:0051303 ! establishment of chromosome localization relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0090221 name: mitotic spindle-templated microtubule nucleation namespace: biological_process def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007020 ! microtubule nucleation [Term] id: GO:0090222 name: centrosome-templated microtubule nucleation namespace: biological_process def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007020 ! microtubule nucleation [Term] id: GO:0090223 name: chromatin-templated microtubule nucleation namespace: biological_process def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007020 ! microtubule nucleation [Term] id: GO:0090224 name: regulation of spindle organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: regulates GO:0007051 ! spindle organization [Term] id: GO:0090225 name: regulation of spindle density namespace: biological_process def: "Any process that modulates the number of microtubules in a given region of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality is_a: GO:0090224 ! regulation of spindle organization [Term] id: GO:0090226 name: regulation of microtubule nucleation by Ran protein signal transduction namespace: biological_process def: "Any series of molecular signals in which a Ran GTPase relays one or more of the signals resulting in the modulation of the rate, frequency or extent of microtubule nucleation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031291 ! Ran protein signal transduction [Term] id: GO:0090227 name: regulation of red or far-red light signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] synonym: "regulation of phytochrome signaling pathway" EXACT [GOC:tb] synonym: "regulation of red or far-red light signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:2000030 ! regulation of response to red or far red light relationship: regulates GO:0010017 ! red or far-red light signaling pathway [Term] id: GO:0090228 name: positive regulation of red or far-red light signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] synonym: "positive regulation of phytochrome signaling pathway" EXACT [GOC:tb] synonym: "positive regulation of red or far-red light signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0090227 ! regulation of red or far-red light signaling pathway relationship: positively_regulates GO:0010017 ! red or far-red light signaling pathway [Term] id: GO:0090229 name: negative regulation of red or far-red light signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] synonym: "negative regulation of phytochrome signaling pathway" EXACT [GOC:tb] synonym: "negative regulation of red or far-red light signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0090227 ! regulation of red or far-red light signaling pathway relationship: negatively_regulates GO:0010017 ! red or far-red light signaling pathway [Term] id: GO:0090230 name: regulation of centromere complex assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "centromere licensing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0044087 ! regulation of cellular component biogenesis relationship: regulates GO:0034508 ! centromere complex assembly [Term] id: GO:0090231 name: regulation of spindle checkpoint namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0031577 ! spindle checkpoint [Term] id: GO:0090232 name: positive regulation of spindle checkpoint namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "spindle checkpoint activation" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0090231 ! regulation of spindle checkpoint relationship: positively_regulates GO:0031577 ! spindle checkpoint [Term] id: GO:0090233 name: negative regulation of spindle checkpoint namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "spindle checkpoint silencing" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0090231 ! regulation of spindle checkpoint relationship: negatively_regulates GO:0031577 ! spindle checkpoint [Term] id: GO:0090234 name: regulation of kinetochore assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0090230 ! regulation of centromere complex assembly relationship: regulates GO:0051382 ! kinetochore assembly [Term] id: GO:0090235 name: regulation of metaphase plate congression namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0051310 ! metaphase plate congression [Term] id: GO:0090236 name: regulation of transcription from RNA polymerase II promoter involved in somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0090237 name: regulation of arachidonic acid secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or group of cells." [GOC:dph, GOC:tb] is_a: GO:0032303 ! regulation of icosanoid secretion relationship: regulates GO:0050482 ! arachidonic acid secretion [Term] id: GO:0090238 name: positive regulation of arachidonic acid secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or group of cells." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032305 ! positive regulation of icosanoid secretion is_a: GO:0090237 ! regulation of arachidonic acid secretion relationship: positively_regulates GO:0050482 ! arachidonic acid secretion [Term] id: GO:0090239 name: regulation of histone H4 acetylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb] is_a: GO:0035065 ! regulation of histone acetylation relationship: regulates GO:0043967 ! histone H4 acetylation [Term] id: GO:0090240 name: positive regulation of histone H4 acetylation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb] is_a: GO:0035066 ! positive regulation of histone acetylation is_a: GO:0090239 ! regulation of histone H4 acetylation relationship: positively_regulates GO:0043967 ! histone H4 acetylation [Term] id: GO:0090241 name: negative regulation of histone H4 acetylation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb] is_a: GO:0035067 ! negative regulation of histone acetylation is_a: GO:0090239 ! regulation of histone H4 acetylation relationship: negatively_regulates GO:0043967 ! histone H4 acetylation [Term] id: GO:0090242 name: retinoic acid receptor signaling pathway involved in somitogenesis namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "retinoic acid receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0090243 name: fibroblast growth factor receptor signaling pathway involved in somitogenesis namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "fibroblast growth factor receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0090244 name: Wnt receptor signaling pathway involved in somitogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Wnt receptor signalling" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0090245 name: axis elongation involved in somitogenesis namespace: biological_process def: "The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003401 ! axis elongation relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0090246 name: convergent extension involved in somitogenesis namespace: biological_process def: "The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060028 ! convergent extension involved in axis elongation relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis [Term] id: GO:0090247 name: cell motility involved in somitogenic axis elongation namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis [Term] id: GO:0090248 name: cell migration involved in somitogenic axis elongation namespace: biological_process def: "The orderly movement of a presomitic mesoderm cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016477 ! cell migration [Term] id: GO:0090249 name: regulation of cell motility involved in somitogenic axis elongation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0014807 ! regulation of somitogenesis is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000145 ! regulation of cell motility relationship: regulates GO:0090247 ! cell motility involved in somitogenic axis elongation [Term] id: GO:0090250 name: cell-cell adhesion involved in establishment of planar polarity namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0001736 ! establishment of planar polarity [Term] id: GO:0090251 name: protein localization involved in establishment of planar polarity namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "protein localisation involved in establishment of planar polarity" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization relationship: part_of GO:0001736 ! establishment of planar polarity [Term] id: GO:0090252 name: epithelium migration involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "The process in which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090132 ! epithelium migration relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0090253 name: convergent extension involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0060029 ! convergent extension involved in organogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0090254 name: cell elongation involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0090255 name: cell proliferation involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0090256 name: regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0090255 ! cell proliferation involved in imaginal disc-derived wing morphogenesis [Term] id: GO:0090257 name: regulation of muscle system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb] is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0003012 ! muscle system process [Term] id: GO:0090258 name: negative regulation of mitochondrial fission namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:sl, GOC:tb] synonym: "negative regulation of mitochondrial division" EXACT [GOC:dph, GOC:tb] is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0090140 ! regulation of mitochondrial fission relationship: negatively_regulates GO:0000266 ! mitochondrial fission [Term] id: GO:0090259 name: regulation of retinal ganglion cell axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb] is_a: GO:0050770 ! regulation of axonogenesis is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:0051270 ! regulation of cellular component movement relationship: regulates GO:0031290 ! retinal ganglion cell axon guidance [Term] id: GO:0090260 name: negative regulation of retinal ganglion cell axon guidance namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb] comment: Note that growth cone collapse has been observed only in assays performed in vitro. synonym: "axon growth cone collapse" RELATED [GOC:curators] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance relationship: negatively_regulates GO:0031290 ! retinal ganglion cell axon guidance [Term] id: GO:0090261 name: positive regulation of inclusion body assembly namespace: biological_process def: "Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:tb] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0090083 ! regulation of inclusion body assembly relationship: positively_regulates GO:0070841 ! inclusion body assembly [Term] id: GO:0090262 name: regulation of transcription-coupled nucleotide-excision repair namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [GOC:tb] is_a: GO:0006282 ! regulation of DNA repair relationship: regulates GO:0006283 ! transcription-coupled nucleotide-excision repair [Term] id: GO:0090263 name: positive regulation of canonical Wnt receptor signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] synonym: "positive regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0030177 ! positive regulation of Wnt receptor signaling pathway is_a: GO:0060828 ! regulation of canonical Wnt receptor signaling pathway relationship: positively_regulates GO:0060070 ! canonical Wnt receptor signaling pathway [Term] id: GO:0090264 name: regulation of immune complex clearance by monocytes and macrophages namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:tb] is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002436 ! immune complex clearance by monocytes and macrophages [Term] id: GO:0090265 name: positive regulation of immune complex clearance by monocytes and macrophages namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:BHF] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0090264 ! regulation of immune complex clearance by monocytes and macrophages relationship: positively_regulates GO:0002436 ! immune complex clearance by monocytes and macrophages [Term] id: GO:0090266 name: regulation of mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0090231 ! regulation of spindle checkpoint relationship: regulates GO:0007094 ! mitotic cell cycle spindle assembly checkpoint [Term] id: GO:0090267 name: positive regulation of mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw] is_a: GO:0090232 ! positive regulation of spindle checkpoint is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint relationship: positively_regulates GO:0007094 ! mitotic cell cycle spindle assembly checkpoint [Term] id: GO:0090268 name: activation of mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint." [GOC:mah, GOC:vw] is_a: GO:0090267 ! positive regulation of mitotic cell cycle spindle assembly checkpoint [Term] id: GO:0090269 name: fibroblast growth factor production namespace: biological_process def: "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0090270 name: regulation of fibroblast growth factor production namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001816 ! cytokine production is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0090269 ! fibroblast growth factor production [Term] id: GO:0090271 name: positive regulation of fibroblast growth factor production namespace: biological_process def: "Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0090270 ! regulation of fibroblast growth factor production relationship: positively_regulates GO:0090269 ! fibroblast growth factor production [Term] id: GO:0090272 name: negative regulation of fibroblast growth factor production namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0090270 ! regulation of fibroblast growth factor production relationship: negatively_regulates GO:0090269 ! fibroblast growth factor production [Term] id: GO:0090273 name: regulation of somatostatin secretion namespace: biological_process def: "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090276 ! regulation of peptide hormone secretion relationship: regulates GO:0070253 ! somatostatin secretion [Term] id: GO:0090274 name: positive regulation of somatostatin secretion namespace: biological_process def: "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090273 ! regulation of somatostatin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion relationship: positively_regulates GO:0070253 ! somatostatin secretion [Term] id: GO:0090275 name: negative regulation of somatostatin secretion namespace: biological_process def: "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090273 ! regulation of somatostatin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion relationship: negatively_regulates GO:0070253 ! somatostatin secretion [Term] id: GO:0090276 name: regulation of peptide hormone secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0030072 ! peptide hormone secretion [Term] id: GO:0090277 name: positive regulation of peptide hormone secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion relationship: positively_regulates GO:0030072 ! peptide hormone secretion [Term] id: GO:0090278 name: negative regulation of peptide hormone secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion relationship: negatively_regulates GO:0030072 ! peptide hormone secretion [Term] id: GO:0090279 name: regulation of calcium ion import namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0051924 ! regulation of calcium ion transport relationship: regulates GO:0070509 ! calcium ion import [Term] id: GO:0090280 name: positive regulation of calcium ion import namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] is_a: GO:0034767 ! positive regulation of ion transmembrane transport is_a: GO:0051928 ! positive regulation of calcium ion transport is_a: GO:0090279 ! regulation of calcium ion import relationship: positively_regulates GO:0070509 ! calcium ion import [Term] id: GO:0090281 name: negative regulation of calcium ion import namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] is_a: GO:0034766 ! negative regulation of ion transmembrane transport is_a: GO:0051926 ! negative regulation of calcium ion transport is_a: GO:0090279 ! regulation of calcium ion import relationship: negatively_regulates GO:0070509 ! calcium ion import [Term] id: GO:0090282 name: positive regulation of transcription involved in G2/M-phase of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M phase of the mitotic cell cycle." [GOC:rn, PMID:10747051, PMID:10894548, PMID:10899128, PMID:10959837] synonym: "activation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn] synonym: "activation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn] synonym: "activation of transcription involved in G2/M-phase of mitotic cell cycle" EXACT [GOC:rn] synonym: "positive regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn] synonym: "positive regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn] synonym: "up-regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn] synonym: "up-regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn] synonym: "up-regulation of transcription involved in G2/M-phase of mitotic cell cycle" EXACT [GOC:rn] is_a: GO:0000117 ! regulation of transcription involved in G2/M-phase of mitotic cell cycle is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter [Term] id: GO:0090283 name: regulation of protein glycosylation in Golgi namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the addition of a sugar unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:tb] synonym: "regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] is_a: GO:0060049 ! regulation of protein glycosylation relationship: regulates GO:0033578 ! protein glycosylation in Golgi [Term] id: GO:0090284 name: positive regulation of protein glycosylation in Golgi namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the addition of a sugar unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:tb] synonym: "positive regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] is_a: GO:0060050 ! positive regulation of protein glycosylation is_a: GO:0090283 ! regulation of protein glycosylation in Golgi relationship: positively_regulates GO:0033578 ! protein glycosylation in Golgi [Term] id: GO:0090285 name: negative regulation of protein glycosylation in Golgi namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the addition of a sugar unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:tb] synonym: "negative regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] is_a: GO:0060051 ! negative regulation of protein glycosylation is_a: GO:0090283 ! regulation of protein glycosylation in Golgi relationship: negatively_regulates GO:0033578 ! protein glycosylation in Golgi [Term] id: GO:0090286 name: cytoskeletal anchoring at nuclear membrane namespace: biological_process def: "The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane." [GOC:tb] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0032507 ! maintenance of protein location in cell [Term] id: GO:0090287 name: regulation of cellular response to growth factor stimulus namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0071363 ! cellular response to growth factor stimulus [Term] id: GO:0090288 name: negative regulation of cellular response to growth factor stimulus namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus relationship: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus [Term] id: GO:0090289 name: regulation of osteoclast proliferation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070663 ! regulation of leukocyte proliferation relationship: regulates GO:0002158 ! osteoclast proliferation [Term] id: GO:0090290 name: positive regulation of osteoclast proliferation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070665 ! positive regulation of leukocyte proliferation is_a: GO:0090289 ! regulation of osteoclast proliferation relationship: positively_regulates GO:0002158 ! osteoclast proliferation [Term] id: GO:0090291 name: negative regulation of osteoclast proliferation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070664 ! negative regulation of leukocyte proliferation is_a: GO:0090289 ! regulation of osteoclast proliferation relationship: negatively_regulates GO:0002158 ! osteoclast proliferation [Term] id: GO:0090292 name: nuclear matrix anchoring at nuclear membrane namespace: biological_process def: "The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane." [GOC:tb] synonym: "nucleoskeleton anchoring at nuclear membrane" EXACT [GOC:tb] is_a: GO:0043578 ! nuclear matrix organization is_a: GO:0051457 ! maintenance of protein location in nucleus [Term] id: GO:0090293 name: nitrogen catabolite regulation of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072] synonym: "regulation of transcription by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0006808 ! regulation of nitrogen utilization is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0071417 ! cellular response to organic nitrogen [Term] id: GO:0090294 name: nitrogen catabolite activation of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072] synonym: "positive regulation of transcription by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent is_a: GO:0090293 ! nitrogen catabolite regulation of transcription [Term] id: GO:0090295 name: nitrogen catabolite repression of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072] synonym: "negative regulation of transcription by nitrogen catabolites" EXACT [GOC:mah] synonym: "nitrogen catabolite repression" EXACT [GOC:mah, GOC:rb] is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent is_a: GO:0090293 ! nitrogen catabolite regulation of transcription [Term] id: GO:0090296 name: regulation of mitochondrial DNA replication namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: regulates GO:0006264 ! mitochondrial DNA replication [Term] id: GO:0090297 name: positive regulation of mitochondrial DNA replication namespace: biological_process def: "Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb] is_a: GO:0090296 ! regulation of mitochondrial DNA replication is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication relationship: positively_regulates GO:0006264 ! mitochondrial DNA replication [Term] id: GO:0090298 name: negative regulation of mitochondrial DNA replication namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb] is_a: GO:0090296 ! regulation of mitochondrial DNA replication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication relationship: negatively_regulates GO:0006264 ! mitochondrial DNA replication [Term] id: GO:0090299 name: regulation of neural crest formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0014029 ! neural crest formation [Term] id: GO:0090300 name: positive regulation of neural crest formation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb] is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition is_a: GO:0090299 ! regulation of neural crest formation relationship: positively_regulates GO:0014029 ! neural crest formation [Term] id: GO:0090301 name: negative regulation of neural crest formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb] is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition is_a: GO:0090299 ! regulation of neural crest formation relationship: negatively_regulates GO:0014029 ! neural crest formation [Term] id: GO:0090302 name: mitotic anaphase-promoting complex activity namespace: molecular_function def: "A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition" EXACT [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0004842 ! ubiquitin-protein ligase activity [Term] id: GO:0090303 name: positive regulation of wound healing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0061041 ! regulation of wound healing relationship: positively_regulates GO:0042060 ! wound healing [Term] id: GO:0090304 name: nucleic acid metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Term] id: GO:0090305 name: nucleic acid phosphodiester bond hydrolysis namespace: biological_process def: "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] synonym: "nucleic acid cleavage" EXACT [GOC:dph, GOC:tb] is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0090306 name: spindle assembly involved in meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis." [GOC:tb, GOC:vw] synonym: "meiotic spindle assembly" EXACT [GOC:vw] is_a: GO:0000212 ! meiotic spindle organization is_a: GO:0051225 ! spindle assembly relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0090307 name: spindle assembly involved in mitosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis." [GOC:tb, GOC:vw] synonym: "mitotic spindle assembly" EXACT [GOC:vw] is_a: GO:0007052 ! mitotic spindle organization is_a: GO:0051225 ! spindle assembly relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0090308 name: regulation of methylation-dependent chromatin silencing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:0033044 ! regulation of chromosome organization relationship: regulates GO:0006346 ! methylation-dependent chromatin silencing [Term] id: GO:0090309 name: positive regulation of methylation-dependent chromatin silencing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0090308 ! regulation of methylation-dependent chromatin silencing relationship: positively_regulates GO:0006346 ! methylation-dependent chromatin silencing [Term] id: GO:0090310 name: negative regulation of methylation-dependent chromatin silencing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0090308 ! regulation of methylation-dependent chromatin silencing relationship: negatively_regulates GO:0006346 ! methylation-dependent chromatin silencing [Term] id: GO:0090311 name: regulation of protein deacetylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:tb] synonym: "regulation of protein amino acid deacetylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0006476 ! protein deacetylation [Term] id: GO:0090312 name: positive regulation of protein deacetylation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ecd, PMID:20027304] synonym: "positive regulation of protein amino acid deacetylation" EXACT [GOC:bf] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0090311 ! regulation of protein deacetylation relationship: positively_regulates GO:0006476 ! protein deacetylation [Term] id: GO:0090313 name: regulation of protein targeting to membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] is_a: GO:0033157 ! regulation of intracellular protein transport relationship: regulates GO:0006612 ! protein targeting to membrane [Term] id: GO:0090314 name: positive regulation of protein targeting to membrane namespace: biological_process def: "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] is_a: GO:0090313 ! regulation of protein targeting to membrane is_a: GO:0090316 ! positive regulation of intracellular protein transport relationship: positively_regulates GO:0006612 ! protein targeting to membrane [Term] id: GO:0090315 name: negative regulation of protein targeting to membrane namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] is_a: GO:0090313 ! regulation of protein targeting to membrane is_a: GO:0090317 ! negative regulation of intracellular protein transport relationship: negatively_regulates GO:0006612 ! protein targeting to membrane [Term] id: GO:0090316 name: positive regulation of intracellular protein transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051222 ! positive regulation of protein transport relationship: positively_regulates GO:0006886 ! intracellular protein transport [Term] id: GO:0090317 name: negative regulation of intracellular protein transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051224 ! negative regulation of protein transport relationship: negatively_regulates GO:0006886 ! intracellular protein transport [Term] id: GO:0090318 name: regulation of chylomicron remodeling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0034371 ! chylomicron remodeling [Term] id: GO:0090319 name: positive regulation of chylomicron remodeling namespace: biological_process def: "Any process that increases the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090318 ! regulation of chylomicron remodeling relationship: positively_regulates GO:0034371 ! chylomicron remodeling [Term] id: GO:0090320 name: regulation of chylomicron remnant clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance relationship: regulates GO:0034382 ! chylomicron remnant clearance [Term] id: GO:0090321 name: positive regulation of chylomicron remnant clearance namespace: biological_process def: "Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF] is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance is_a: GO:0090320 ! regulation of chylomicron remnant clearance relationship: positively_regulates GO:0034382 ! chylomicron remnant clearance [Term] id: GO:0090322 name: regulation of superoxide metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:tb] synonym: "regulation of superoxide metabolism" EXACT [GOC:tb] is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process relationship: regulates GO:0006801 ! superoxide metabolic process [Term] id: GO:0090323 name: prostaglandin secretion involved in immune response namespace: biological_process def: "The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring." [GOC:dph, GOC:tb] is_a: GO:0002440 ! production of molecular mediator of immune response is_a: GO:0032310 ! prostaglandin secretion [Term] id: GO:0090324 name: negative regulation of oxidative phosphorylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:BHF] is_a: GO:0002082 ! regulation of oxidative phosphorylation is_a: GO:0042326 ! negative regulation of phosphorylation [Term] id: GO:0090325 name: regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050795 ! regulation of behavior relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior [Term] id: GO:0090326 name: positive regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior relationship: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior [Term] id: GO:0090327 name: negative regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior relationship: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior [Term] id: GO:0090328 name: regulation of olfactory learning namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb] is_a: GO:0031644 ! regulation of neurological system process is_a: GO:0050795 ! regulation of behavior relationship: regulates GO:0008355 ! olfactory learning [Term] id: GO:0090329 name: regulation of DNA-dependent DNA replication namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:dph, GOC:tb] is_a: GO:0006275 ! regulation of DNA replication relationship: regulates GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0090330 name: regulation of platelet aggregation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:dph, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion relationship: regulates GO:0070527 ! platelet aggregation [Term] id: GO:0090331 name: negative regulation of platelet aggregation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF] is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion is_a: GO:0090330 ! regulation of platelet aggregation relationship: negatively_regulates GO:0070527 ! platelet aggregation [Term] id: GO:0090332 name: stomatal closure namespace: biological_process def: "The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb] is_a: GO:0010118 ! stomatal movement [Term] id: GO:0090333 name: regulation of stomatal closure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb] is_a: GO:0010119 ! regulation of stomatal movement relationship: regulates GO:0090332 ! stomatal closure [Term] id: GO:0090334 name: regulation of cell wall 1,3-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of cells." [GOC:tb] synonym: "regulation of cell wall 1,3-beta-glucan biosynthetic process" BROAD [] is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0032953 ! regulation of 1,3-beta-D-glucan biosynthetic process is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis relationship: regulates GO:0034411 ! cell wall 1,3-beta-D-glucan biosynthetic process [Term] id: GO:0090335 name: regulation of brown fat cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:tb] is_a: GO:0045598 ! regulation of fat cell differentiation relationship: regulates GO:0050873 ! brown fat cell differentiation [Term] id: GO:0090336 name: positive regulation of brown fat cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:BHF] is_a: GO:0045600 ! positive regulation of fat cell differentiation is_a: GO:0090335 ! regulation of brown fat cell differentiation relationship: positively_regulates GO:0050873 ! brown fat cell differentiation [Term] id: GO:0090337 name: regulation of formin-nucleated actin cable assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184] is_a: GO:0032231 ! regulation of actin filament bundle assembly relationship: regulates GO:0070649 ! formin-nucleated actin cable assembly [Term] id: GO:0090338 name: positive regulation of formin-nucleated actin cable assembly namespace: biological_process def: "Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184] is_a: GO:0032233 ! positive regulation of actin filament bundle assembly is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly relationship: positively_regulates GO:0070649 ! formin-nucleated actin cable assembly [Term] id: GO:0090339 name: negative regulation of formin-nucleated actin cable assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184] is_a: GO:0032232 ! negative regulation of actin filament bundle assembly is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly relationship: negatively_regulates GO:0070649 ! formin-nucleated actin cable assembly [Term] id: GO:0090340 name: positive regulation of secretion of lysosomal enzymes namespace: biological_process def: "Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell or group of cells." [GOC:BHF] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes relationship: positively_regulates GO:0033299 ! secretion of lysosomal enzymes [Term] id: GO:0090341 name: negative regulation of secretion of lysosomal enzymes namespace: biological_process def: "Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell or group of cells." [GOC:BHF] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes relationship: negatively_regulates GO:0033299 ! secretion of lysosomal enzymes [Term] id: GO:0090342 name: regulation of cell aging namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of cellular senescence" EXACT [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007569 ! cell aging [Term] id: GO:0090343 name: positive regulation of cell aging namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of cellular senescence" EXACT [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0090342 ! regulation of cell aging relationship: positively_regulates GO:0007569 ! cell aging [Term] id: GO:0090344 name: negative regulation of cell aging namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of cellular senescence" EXACT [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0090342 ! regulation of cell aging relationship: negatively_regulates GO:0007569 ! cell aging [Term] id: GO:0090345 name: cellular organohalogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0090346 name: cellular organofluorine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0090345 ! cellular organohalogen metabolic process [Term] id: GO:0090347 name: regulation of cellular organohalogen metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0090345 ! cellular organohalogen metabolic process [Term] id: GO:0090348 name: regulation of cellular organofluorine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0090347 ! regulation of cellular organohalogen metabolic process relationship: regulates GO:0090346 ! cellular organofluorine metabolic process [Term] id: GO:0090349 name: negative regulation of cellular organohalogen metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0090347 ! regulation of cellular organohalogen metabolic process relationship: negatively_regulates GO:0090345 ! cellular organohalogen metabolic process [Term] id: GO:0090350 name: negative regulation of cellular organofluorine metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0090348 ! regulation of cellular organofluorine metabolic process is_a: GO:0090349 ! negative regulation of cellular organohalogen metabolic process relationship: negatively_regulates GO:0090346 ! cellular organofluorine metabolic process [Term] id: GO:0090351 name: seedling development namespace: biological_process def: "The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge." [GOC:tb, PO:0007131] xref: PO:0008037 is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0090352 name: regulation of nitrate assimilation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances." [GOC:tb] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: regulates GO:0042128 ! nitrate assimilation [Term] id: GO:0090353 name: polygalacturonase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a polygalacturonase. Polygalacturonases catalyze the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0090354 name: regulation of auxin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb] synonym: "regulation of auxin metabolism" EXACT [GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: regulates GO:0009850 ! auxin metabolic process [Term] id: GO:0090355 name: positive regulation of auxin metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb] synonym: "positive regulation of auxin metabolism" EXACT [GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0090354 ! regulation of auxin metabolic process relationship: positively_regulates GO:0009850 ! auxin metabolic process [Term] id: GO:0090356 name: negative regulation of auxin metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb] synonym: "negative regulation of auxin metabolism" EXACT [GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0090354 ! regulation of auxin metabolic process relationship: negatively_regulates GO:0009850 ! auxin metabolic process [Term] id: GO:0090357 name: regulation of tryptophan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb] synonym: "regulation of tryptophan metabolism" EXACT [GOC:tb] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process relationship: regulates GO:0006568 ! tryptophan metabolic process [Term] id: GO:0090358 name: positive regulation of tryptophan metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb] synonym: "positive regulation of tryptophan metabolism" EXACT [GOC:tb] is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:0090357 ! regulation of tryptophan metabolic process relationship: positively_regulates GO:0006568 ! tryptophan metabolic process [Term] id: GO:0090359 name: negative regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:tb] synonym: "negative regulation of abscisic acid biosynthesis" EXACT [GOC:tb] is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process relationship: negatively_regulates GO:0009688 ! abscisic acid biosynthetic process [Term] id: GO:0090360 name: platelet-derived growth factor production namespace: biological_process def: "The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0090361 name: regulation of platelet-derived growth factor production namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0090360 ! platelet-derived growth factor production [Term] id: GO:0090362 name: positive regulation of platelet-derived growth factor production namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0090361 ! regulation of platelet-derived growth factor production relationship: positively_regulates GO:0090360 ! platelet-derived growth factor production [Term] id: GO:0090363 name: regulation of proteasome core complex assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [GOC:dph, GOC:elh, GOC:tb] is_a: GO:0090364 ! regulation of proteasome assembly relationship: regulates GO:0080129 ! proteasome core complex assembly [Term] id: GO:0090364 name: regulation of proteasome assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:dph, GOC:elh, GOC:tb] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0043248 ! proteasome assembly [Term] id: GO:0090365 name: regulation of mRNA modification namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb, PMID:14559896] synonym: "regulation of mRNA editing" NARROW [] is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0016556 ! mRNA modification [Term] id: GO:0090366 name: positive regulation of mRNA modification namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:0090365 ! regulation of mRNA modification relationship: positively_regulates GO:0016556 ! mRNA modification [Term] id: GO:0090367 name: negative regulation of mRNA modification namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:0090365 ! regulation of mRNA modification relationship: negatively_regulates GO:0016556 ! mRNA modification [Term] id: GO:0090368 name: regulation of ornithine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process relationship: regulates GO:0006591 ! ornithine metabolic process [Term] id: GO:0090369 name: ornithine carbamoyltransferase inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces ornithine carbamoyltransferase activity, the catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0090370 name: negative regulation of cholesterol efflux namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:dph, GOC:tb] is_a: GO:0010874 ! regulation of cholesterol efflux is_a: GO:0032375 ! negative regulation of cholesterol transport relationship: negatively_regulates GO:0033344 ! cholesterol efflux [Term] id: GO:0090371 name: regulation of glycerol transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0015793 ! glycerol transport [Term] id: GO:0090372 name: positive regulation of glycerol transport namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0090371 ! regulation of glycerol transport relationship: positively_regulates GO:0015793 ! glycerol transport [Term] id: GO:0090373 name: negative regulation of glycerol transport namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0090371 ! regulation of glycerol transport relationship: negatively_regulates GO:0015793 ! glycerol transport [Term] id: GO:0090374 name: oligopeptide export from mitochondrion namespace: biological_process def: "The directed movement of oligopeptides out of mitochondria into the cytosol by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0035672 ! oligopeptide transmembrane transport [Term] id: GO:0090375 name: negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of iron ions." [GOC:tb] synonym: "negative regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [GOC:tb] is_a: GO:0033217 ! regulation of transcription from RNA polymerase II promoter in response to iron ion starvation [Term] id: GO:0090376 name: seed trichome differentiation namespace: biological_process def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function." [GOC:tb, PMID:17905721] synonym: "cotton fiber development" NARROW [GOC:tb] synonym: "seed hair differentiation" EXACT [PO:0004511] synonym: "seed trichome development" RELATED [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010026 ! trichome differentiation is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0048316 ! seed development [Term] id: GO:0090377 name: seed trichome initiation namespace: biological_process def: "The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis." [PMID:17905721] comment: These processes continue up to 3 days post-anthesis (DPA) in Gossypium spp. synonym: "seed trichome fate commitment" EXACT [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0090376 ! seed trichome differentiation [Term] id: GO:0090378 name: seed trichome elongation namespace: biological_process def: "The process in which a seed trichome irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [GOC:tb] comment: The increase in length of the seed trichome without cell division. Elongation is defined to be from 5 to 20 DPA in Gossypium spp. is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0090376 ! seed trichome differentiation [Term] id: GO:0090379 name: secondary cell wall biogenesis involved in seed trichome differentiation namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall of seed trichomes after cell expansion is complete." [GOC:tb] comment: The processes involved in the massive amount of secondary wall cellulose synthesis in seed trichomes continue to 30 DPA in Gossypium spp. synonym: "secondary cell wall biosynthesis involved in seed trichome differentiation" EXACT [GOC:tb] synonym: "seed trichome secondary wall biosynthesis" RELATED [GOC:tb] is_a: GO:0009834 ! secondary cell wall biogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0090376 ! seed trichome differentiation [Term] id: GO:0090380 name: seed trichome maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a seed trichome to attain its fully functional state." [GOC:tb] comment: These processes continue to 60 DPA in Gossypium spp. is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048469 ! cell maturation relationship: part_of GO:0090376 ! seed trichome differentiation [Term] id: GO:0090381 name: regulation of heart induction namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling relationship: regulates GO:0003129 ! heart induction [Term] id: GO:0090382 name: phagosome maturation namespace: biological_process def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb] is_a: GO:0006996 ! organelle organization [Term] id: GO:0090383 name: phagosome acidification namespace: biological_process def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion." [GOC:kmv, GOC:tb] synonym: "phagosomal acidification" EXACT [GOC:kmv, GOC:tb] is_a: GO:0051452 ! intracellular pH reduction relationship: part_of GO:0090382 ! phagosome maturation [Term] id: GO:0090384 name: phagosome-lysosome docking namespace: biological_process def: "The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb] synonym: "lysosome recruitment to phagosome" EXACT [GOC:kmv, GOC:tb] is_a: GO:0022406 ! membrane docking relationship: part_of GO:0001845 ! phagolysosome assembly [Term] id: GO:0090385 name: phagosome-lysosome fusion namespace: biological_process def: "The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb] is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0001845 ! phagolysosome assembly [Term] id: GO:0090386 name: phagosome maturation involved in apoptotic cell clearance namespace: biological_process def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb] is_a: GO:0090382 ! phagosome maturation relationship: part_of GO:0043277 ! apoptotic cell clearance [Term] id: GO:0090387 name: phagolysosome assembly involved in apoptotic cell clearance namespace: biological_process def: "The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb] is_a: GO:0001845 ! phagolysosome assembly relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance [Term] id: GO:0090388 name: phagosome-lysosome docking involved in apoptotic cell clearance namespace: biological_process def: "The initial attachment of a phagosome membrane to a lysosome membrane that occurs as a part of apoptotic cell clearance. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb] is_a: GO:0090384 ! phagosome-lysosome docking relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance [Term] id: GO:0090389 name: phagosome-lysosome fusion involved in apoptotic cell clearance namespace: biological_process def: "The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb] is_a: GO:0090385 ! phagosome-lysosome fusion relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance [Term] id: GO:0090390 name: phagosome acidification involved in apoptotic cell clearance namespace: biological_process def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion, and occurs as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb] is_a: GO:0090383 ! phagosome acidification relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance [Term] id: GO:0090391 name: granum assembly namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts." [GOC:tb] synonym: "grana formation" EXACT [GOC:tb] is_a: GO:0071844 ! cellular component assembly at cellular level relationship: part_of GO:0009658 ! chloroplast organization [Term] id: GO:0090392 name: sepal giant cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sepal giant cell. A sepal giant cell is a pavement cell that is part of the sepal epidermis and stretches one fifth the length of the sepal with a chromosome content of 16C." [GOC:tb, PMID:20485493] is_a: GO:0009913 ! epidermal cell differentiation [Term] id: GO:0090393 name: sepal giant cell development namespace: biological_process def: "The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:tb] synonym: "sepal giant cell formation" RELATED [GOC:tb] is_a: GO:0048468 ! cell development relationship: part_of GO:0090392 ! sepal giant cell differentiation [Term] id: GO:0090394 name: negative regulation of excitatory postsynaptic membrane potential namespace: biological_process def: "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:BHF] synonym: "negative regulation of EPSP" RELATED [] synonym: "reduction of excitatory postsynaptic membrane potential" EXACT [GOC:bf] is_a: GO:0045837 ! negative regulation of membrane potential is_a: GO:0060079 ! regulation of excitatory postsynaptic membrane potential [Term] id: GO:0090395 name: plant cell papilla namespace: cellular_component def: "A cell projection that is a short, rounded projection from a plant epidermal cell." [GOC:tb] comment: Part of papilla cell (PO:0025166), which is a shoot epidermal cell (PO:0025165) in plants. Replaces the obsolete term papillae (PO:0002001). is_a: GO:0042995 ! cell projection [Term] id: GO:0090396 name: leaf papilla namespace: cellular_component def: "A plant cell papilla that is part of a leaf papilla cell." [GOC:tb] comment: Part of leaf papilla cell (PO:0025167). is_a: GO:0090395 ! plant cell papilla [Term] id: GO:0090397 name: stigma papilla namespace: cellular_component def: "A plant cell papilla that is part of a stigma papilla cell." [GOC:tb] comment: Part of stigma papilla cell (PO:0025168). is_a: GO:0090395 ! plant cell papilla [Term] id: GO:0090398 name: cellular senescence namespace: biological_process def: "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF] is_a: GO:0007569 ! cell aging is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0090399 name: replicative senescence namespace: biological_process def: "A cellular senescence process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging." [GOC:BHF] is_a: GO:0090398 ! cellular senescence [Term] id: GO:0090400 name: stress-induced premature senescence namespace: biological_process def: "A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays." [GOC:BHF] synonym: "SIPS" EXACT [GOC:BHF] is_a: GO:0090398 ! cellular senescence [Term] id: GO:0090401 name: viral-induced premature senescence namespace: biological_process def: "A cellular senescence process associated with the dismantling of a cell as a response to viral infection." [GOC:BHF] is_a: GO:0051607 ! defense response to virus is_a: GO:0090400 ! stress-induced premature senescence [Term] id: GO:0090402 name: oncogene-induced senescence namespace: biological_process def: "A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family." [GOC:BHF] synonym: "OIS" EXACT [GOC:BHF] is_a: GO:0090398 ! cellular senescence [Term] id: GO:0090403 name: oxidative stress-induced premature senescence namespace: biological_process def: "A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals." [GOC:BHF] is_a: GO:0034599 ! cellular response to oxidative stress is_a: GO:0090400 ! stress-induced premature senescence [Term] id: GO:0090404 name: pollen tube tip namespace: cellular_component def: "The region at growing end of the pollen tube cell, where polarized growth occurs." [GOC:tb] is_a: GO:0035838 ! growing cell tip is_a: GO:0044463 ! cell projection part relationship: part_of GO:0090406 ! pollen tube [Term] id: GO:0090405 name: unicellular trichome branch namespace: cellular_component def: "A cell projection part that is a branch of a unicellular trichome." [GOC:tb] comment: Unicellular trichome branch is part of unicellular trichome, which is a narrow synonym of trichome cell (PO:0008030). For a cell that forms a branch of a multicellular trichome, see multicellular trichome branch cell (PO:0025163). is_a: GO:0044463 ! cell projection part [Term] id: GO:0090406 name: pollen tube namespace: cellular_component def: "A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain." [GOC:tb] comment: Carries the male gametes to into or near the ovule. May be branched in gymnosperms. This term replaces the obsolete term PO:0006345. Part of pollen tube cell (PO:0025195). is_a: GO:0042995 ! cell projection [Term] id: GO:0090407 name: organophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] is_a: GO:0009058 ! biosynthetic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0090408 name: phloem nitrate loading namespace: biological_process def: "The process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:tb] synonym: "phloem loading" BROAD [] is_a: GO:0010233 ! phloem transport is_a: GO:0015706 ! nitrate transport [Term] id: GO:0097001 name: ceramide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any ceramide, a class of lipids that is composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes." [CHEBI:17761, GOC:sart] is_a: GO:0046625 ! sphingolipid binding [Term] id: GO:0097002 name: mitochondrial inner boundary membrane namespace: cellular_component def: "The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane." [GOC:mcc, PMID:16054341, PMID:19019989] is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0097003 name: adipokinetic hormone receptor activity namespace: molecular_function def: "Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] synonym: "AKH receptor activity" EXACT [] is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0097004 name: adipokinetic hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] synonym: "AKH binding" EXACT [] is_a: GO:0017046 ! peptide hormone binding [Term] id: GO:0097005 name: adipokinetic hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] synonym: "AKH receptor binding" EXACT [] is_a: GO:0051428 ! peptide hormone receptor binding [Term] id: GO:0097006 name: regulation of plasma lipoprotein particle levels namespace: biological_process def: "Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism." [GOC:BHF] synonym: "plasma lipoprotein particle homeostasis" NARROW [] is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0097007 name: 4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = TMTT + NADP+ + 2H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce TMTT and acetone." [GOC:kad, MetaCyc:RXN-8620, PMID:21088219] synonym: "4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity" EXACT [] synonym: "TMTT synthase activity" EXACT [] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0097008 name: (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = DMNT + NADP+ + 2H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce DMNT and acetone." [GOC:kad, MetaCyc:RXN-8619, PMID:21088219] synonym: "(3E)-4,8-dimethylnona-1,3,7-triene synthase activity" EXACT [] synonym: "DMNT synthase activity" EXACT [] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0097009 name: energy homeostasis namespace: biological_process def: "Any process involved in the balance between food intake (energy input) and energy expenditure." [GOC:yaf, PMID:15919751] is_a: GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0097010 name: eukaryotic translation initiation factor 4F complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex." [GOC:BHF, GOC:ebc, PMID:18337562] synonym: "eIF-4F assembly" EXACT [GOC:pr] synonym: "eIF4F assembly" EXACT [GOC:pr] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0097011 name: cellular response to granulocyte macrophage colony-stimulating factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:BHF, GOC:ebc, PMID:7901744] synonym: "cellular response to GM-CSF stimulus" EXACT [] is_a: GO:0071345 ! cellular response to cytokine stimulus is_a: GO:0097012 ! response to granulocyte macrophage colony-stimulating factor stimulus [Term] id: GO:0097012 name: response to granulocyte macrophage colony-stimulating factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:pr] synonym: "response to GM-CSF" EXACT [] is_a: GO:0034097 ! response to cytokine stimulus [Term] id: GO:0097013 name: phagocytic vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a phagocytic vesicle." [GOC:rs] is_a: GO:0071682 ! endocytic vesicle lumen relationship: part_of GO:0045335 ! phagocytic vesicle [Term] id: GO:0097014 name: microtubule-based flagellar cytoplasm namespace: cellular_component def: "All of the contents of a microtubule-based flagellum, excluding the plasma membrane surrounding the flagellum." [GOC:BHF, PMID:17895364] synonym: "microtubule-based flagellar matrix" NARROW [] synonym: "microtubule-based flagellum cytoplasm" EXACT [] synonym: "microtubule-based flagellum matrix" NARROW [] is_a: GO:0032838 ! cell projection cytoplasm is_a: GO:0044442 ! microtubule-based flagellum part [Term] id: GO:0097015 name: bacterial-type flagellar cytoplasm namespace: cellular_component def: "All of the contents of a bacterial-type flagellum, excluding the plasma membrane surrounding the flagellum." [GOC:BHF] synonym: "bacterial-type flagellum cytoplasm" EXACT [] is_a: GO:0032838 ! cell projection cytoplasm is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0097016 name: L27 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner." [GOC:BHF, PMID:15241471, PMID:17237226, Prosite:PDOC51022] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0097017 name: renal protein absorption namespace: biological_process def: "A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron." [GOC:yaf, PMID:18431508] is_a: GO:0070293 ! renal absorption [Term] id: GO:0097018 name: renal albumin absorption namespace: biological_process def: "A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron." [GOC:yaf, PMID:18431508] is_a: GO:0097017 ! renal protein absorption [Term] id: GO:0097019 name: neurotransmitter receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of neurotransmitter receptors." [GOC:kmv] synonym: "neurotransmitter receptor breakdown" EXACT [] synonym: "neurotransmitter receptor catabolism" EXACT [] synonym: "neurotransmitter receptor degradation" EXACT [] is_a: GO:0032801 ! receptor catabolic process is_a: GO:0045213 ! neurotransmitter receptor metabolic process [Term] id: GO:0097020 name: COPII adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together the COPII vesicle proteins and one or more other molecules, permitting them to function in a coordinated way." [GOC:rb, PMID:16957051, PMID:20236934] is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0097021 name: lymphocyte migration into lymphoid organs namespace: biological_process def: "The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575] synonym: "lymphocyte homing" NARROW [] is_a: GO:0072676 ! lymphocyte migration [Term] id: GO:0097022 name: lymphocyte migration into lymph node namespace: biological_process def: "The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575] synonym: "lymphocyte homing" EXACT [] is_a: GO:0097021 ! lymphocyte migration into lymphoid organs [Term] id: GO:0097023 name: fructose 6-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate." [GOC:imk, PMID:11120740, PMID:21290439] is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0097024 name: protein kinase C alpha binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein kinase C alpha." [GOC:BHF, PMID:16014375] synonym: "PKC alpha binding" EXACT [] is_a: GO:0005080 ! protein kinase C binding [Term] id: GO:0097025 name: MPP7-DLG1-LIN7 complex namespace: cellular_component def: "A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions." [GOC:BHF, PMID:17237226] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005912 ! adherens junction [Term] id: GO:0097026 name: dendritic cell dendrite assembly namespace: biological_process def: "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, PMID:12200351] comment: Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals. synonym: "dendritic extension" BROAD [] is_a: GO:0030031 ! cell projection assembly [Term] id: GO:0097027 name: ubiquitin-protein ligase activator activity namespace: molecular_function def: "Increases the activity of a ubiquitin-protein ligase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:rb, PMID:18321851] is_a: GO:0055106 ! ubiquitin-protein ligase regulator activity [Term] id: GO:0097028 name: dendritic cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:pr] comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. is_a: GO:0002521 ! leukocyte differentiation [Term] id: GO:0097029 name: mature dendritic cell differentiation namespace: biological_process def: "The process in which antigen-activated dendritic cells acquire the specialized features of a mature dendritic cell. Mature dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells." [GOC:BHF, http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.aspx, PMID:15845453] comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. is_a: GO:0097028 ! dendritic cell differentiation [Term] id: GO:0097030 name: centromere-specific nucleosome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:jp, PMID:21412236] synonym: "centromeric nucleosome binding" EXACT [] is_a: GO:0031491 ! nucleosome binding [Term] id: GO:0097031 name: mitochondrial respiratory chain complex I biogenesis namespace: biological_process def: "The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr] is_a: GO:0070271 ! protein complex biogenesis [Term] id: GO:0097032 name: mitochondrial respiratory chain complex II biogenesis namespace: biological_process def: "The biogenesis of a mitochondrial respiratory chain complex II, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr] is_a: GO:0070271 ! protein complex biogenesis [Term] id: GO:0097033 name: mitochondrial respiratory chain complex III biogenesis namespace: biological_process def: "The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc] synonym: "mitochondrial cytochrome bc(1) complex biogenesis" EXACT [GOC:pr] is_a: GO:0070271 ! protein complex biogenesis [Term] id: GO:0097034 name: mitochondrial respiratory chain complex IV biogenesis namespace: biological_process def: "The biogenesis of a mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase complex), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc] synonym: "mitochondrial cytochrome c oxidase complex biogenesis" EXACT [GOC:pr] is_a: GO:0070271 ! protein complex biogenesis [Term] id: GO:0097035 name: regulation of membrane lipid distribution namespace: biological_process def: "Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909] is_a: GO:0016044 ! cellular membrane organization is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0097036 name: regulation of plasma membrane sterol distribution namespace: biological_process def: "Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane." [CHEBI:15889, GOC:mah, PMID:18441123, PMID:20823909] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0097035 ! regulation of membrane lipid distribution [Term] id: GO:0097037 name: heme export namespace: biological_process def: "The directed movement of heme out of a cell or organelle." [GOC:lf, PMID:15369674, PMID:20610401] is_a: GO:0015886 ! heme transport [Term] id: GO:0097038 name: perinuclear endoplasmic reticulum namespace: cellular_component def: "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] synonym: "perinuclear ER" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0048471 ! perinuclear region of cytoplasm [Term] id: GO:0097039 name: protein linear polyubiquitination namespace: biological_process def: "A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein." [GOC:jsg, GOC:sp, PMID:21455173, PMID:21455180, PMID:21455181] synonym: "M1 linkage" NARROW [] is_a: GO:0000209 ! protein polyubiquitination [Term] id: GO:0097040 name: phthiocerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents." [CHEBI:59240, GOC:dph, GOC:ecd, PMID:9201977] synonym: "phthiocerol anabolism" EXACT [] synonym: "phthiocerol biosynthesis" EXACT [] synonym: "phthiocerol formation" EXACT [] synonym: "phthiocerol synthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0042845 ! glycol biosynthetic process [Term] id: GO:0097041 name: phenolic phthiocerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position." [CHEBI:59237, GOC:dph, GOC:ecd, PMID:9201977] synonym: "phenolic phthiocerol anabolism" EXACT [] synonym: "phenolic phthiocerol biosynthesis" EXACT [] synonym: "phenolic phthiocerol formation" EXACT [] synonym: "phenolic phthiocerol synthesis" EXACT [] synonym: "phenolphthiocerol biosynthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0097042 name: extrinsic to fungal-type vacuolar membrane namespace: cellular_component def: "Loosely bound to one surface of the fungal-type vacuolar membrane, but not integrated into the hydrophobic region." [GOC:jh, PMID:21454883] is_a: GO:0000306 ! extrinsic to vacuolar membrane relationship: part_of GO:0000329 ! fungal-type vacuole membrane [Term] id: GO:0097043 name: histone H3-K56 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone." [GOC:bf, GOC:pr] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0097044 name: histone H3-K56 acetylation in response to DNA damage namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone as a result of the detection of DNA damage within a cell." [GOC:pr, GOC:vw, PMID:18344406] is_a: GO:0006974 ! response to DNA damage stimulus is_a: GO:0097043 ! histone H3-K56 acetylation [Term] id: GO:0097045 name: phosphatidylserine exposure on blood platelet namespace: biological_process def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system." [GOC:bf, GOC:lf, GOC:pr, PMID:21107324] is_a: GO:0017121 ! phospholipid scrambling is_a: GO:0030194 ! positive regulation of blood coagulation [Term] id: GO:0097046 name: replication fork progression beyond termination site namespace: biological_process def: "Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks." [GOC:bf, GOC:mcc, GOC:pr, PMID:20797631] is_a: GO:2000621 ! regulation of DNA replication termination [Term] id: GO:0097047 name: DNA replication termination region namespace: cellular_component def: "A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks." [GOC:mcc, GOC:pr, PMID:20797631] synonym: "TER" EXACT [] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0097048 name: dendritic cell apoptosis namespace: biological_process def: "The process of apoptosis in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:BHF, PMID:15059845] is_a: GO:0071887 ! leukocyte apoptosis [Term] id: GO:0097049 name: motor neuron apoptosis namespace: biological_process def: "The process of apoptosis in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, PMID:14523086] synonym: "motoneuron apoptosis" EXACT [] is_a: GO:0051402 ! neuron apoptosis [Term] id: GO:0097050 name: type B pancreatic cell apoptosis namespace: biological_process def: "The process of apoptosis in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF, PMID:16087305] synonym: "pancreatic B cell apoptosis" EXACT [] synonym: "pancreatic beta cell apoptosis" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0097051 name: establishment of protein localization in endoplasmic reticulum membrane namespace: biological_process def: "The directed movement of a protein to a specific location in the endoplasmic reticulum membrane." [GOC:rb, PMID:9388185] is_a: GO:0090150 ! establishment of protein localization in membrane [Term] id: GO:0097052 name: L-kynurenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [CHEBI:16946, GOC:yaf] synonym: "L-kynurenine metabolism" EXACT [] is_a: GO:0070189 ! kynurenine metabolic process [Term] id: GO:0097053 name: L-kynurenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [CHEBI:16946, GOC:yaf] synonym: "L-kynurenine breakdown" EXACT [] synonym: "L-kynurenine catabolism" EXACT [] synonym: "L-kynurenine degradation" EXACT [] is_a: GO:0097052 ! L-kynurenine metabolic process [Term] id: GO:0097054 name: L-glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid." [GOC:yaf] synonym: "L-glutamate anabolism" EXACT [] synonym: "L-glutamate biosynthesis" EXACT [] synonym: "L-glutamate formation" EXACT [] synonym: "L-glutamate synthesis" EXACT [] is_a: GO:0006537 ! glutamate biosynthetic process [Term] id: GO:0097055 name: agmatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase." [CHEBI:17431, GOC:pr, GOC:yaf] synonym: "agmatine anabolism" EXACT [] synonym: "agmatine biosynthesis" EXACT [] synonym: "agmatine formation" EXACT [] synonym: "agmatine synthesis" EXACT [] is_a: GO:0009309 ! amine biosynthetic process [Term] id: GO:0097056 name: selenocysteinyl-tRNA(Sec) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways by which the amino acid selenocysteine is paired with its cognate tRNA to form selenocysteinyl-tRNA(Sec)." [CHEBI:13166, GOC:yaf] synonym: "selenocysteinyl-tRNA(Sec) anabolism" EXACT [] synonym: "selenocysteinyl-tRNA(Sec) biosynthesis" EXACT [] synonym: "selenocysteinyl-tRNA(Sec) formation" EXACT [] synonym: "selenocysteinyl-tRNA(Sec) synthesis" EXACT [] is_a: GO:0043039 ! tRNA aminoacylation [Term] id: GO:0097057 name: TRAF2-GSTP1 complex namespace: cellular_component def: "A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses." [GOC:BHF, PMID:16636664] is_a: GO:0043234 ! protein complex [Term] id: GO:0097058 name: CRLF-CLCF1 complex namespace: cellular_component def: "A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex." [GOC:BHF, PMID:10966616] synonym: "CLF-CLC complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0097059 name: CNTFR-CLCF1 complex namespace: cellular_component def: "A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space." [GOC:BHF, PMID:11285233] synonym: "sCNTFR-CLC complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0097060 name: synaptic membrane namespace: cellular_component def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104] is_a: GO:0016020 ! membrane is_a: GO:0044456 ! synapse part [Term] id: GO:0097061 name: dendritic spine organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104] synonym: "dendritic spine organisation" EXACT [] is_a: GO:0071842 ! cellular component organization at cellular level [Term] id: GO:0097062 name: dendritic spine maintenance namespace: biological_process def: "The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104] is_a: GO:0071956 ! cellular component maintenance at cellular level is_a: GO:0097061 ! dendritic spine organization [Term] id: GO:0097063 name: cadmium ion sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++)." [GOC:rs, PMID:19456862] is_a: GO:0046870 ! cadmium ion binding [Term] id: GO:0097064 name: ncRNA export from nucleus namespace: biological_process def: "The directed movement of a non-coding RNA transcript (ncRNA) from the nucleus to the cytoplasm." [GOC:dgf, PMID:11352936] synonym: "non-coding RNA export from nucleus" EXACT [GOC:pr] is_a: GO:0006405 ! RNA export from nucleus [Term] id: GO:0097065 name: anterior head development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure." [GOC:yaf, PMID:14695376, PMID:15857913] is_a: GO:0060322 ! head development [Term] id: GO:2000001 name: regulation of DNA damage checkpoint namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol] subset: unvetted synonym: "regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0000077 ! DNA damage checkpoint [Term] id: GO:2000002 name: negative regulation of DNA damage checkpoint namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol] subset: unvetted synonym: "negative regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000001 ! regulation of DNA damage checkpoint relationship: negatively_regulates GO:0000077 ! DNA damage checkpoint [Term] id: GO:2000003 name: positive regulation of DNA damage checkpoint namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol] subset: unvetted synonym: "positive regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2000001 ! regulation of DNA damage checkpoint relationship: positively_regulates GO:0000077 ! DNA damage checkpoint [Term] id: GO:2000004 name: regulation of metanephric S-shaped body morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:obol] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0072284 ! metanephric S-shaped body morphogenesis [Term] id: GO:2000005 name: negative regulation of metanephric S-shaped body morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000004 ! regulation of metanephric S-shaped body morphogenesis relationship: negatively_regulates GO:0072284 ! metanephric S-shaped body morphogenesis [Term] id: GO:2000006 name: regulation of metanephric comma-shaped body morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:obol] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0072278 ! metanephric comma-shaped body morphogenesis [Term] id: GO:2000007 name: negative regulation of metanephric comma-shaped body morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000006 ! regulation of metanephric comma-shaped body morphogenesis relationship: negatively_regulates GO:0072278 ! metanephric comma-shaped body morphogenesis [Term] id: GO:2000008 name: regulation of protein localization at cell surface namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization at cell surface." [GOC:obol] synonym: "regulation of protein localisation at cell surface" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0034394 ! protein localization at cell surface [Term] id: GO:2000009 name: negative regulation of protein localization at cell surface namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization at cell surface." [GOC:obol] synonym: "negative regulation of protein localisation at cell surface" EXACT [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000008 ! regulation of protein localization at cell surface relationship: negatively_regulates GO:0034394 ! protein localization at cell surface [Term] id: GO:2000010 name: positive regulation of protein localization at cell surface namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization at cell surface." [GOC:obol] synonym: "positive regulation of protein localisation at cell surface" EXACT [GOC:mah] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000008 ! regulation of protein localization at cell surface relationship: positively_regulates GO:0034394 ! protein localization at cell surface [Term] id: GO:2000011 name: regulation of adaxial/abaxial pattern formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation." [GOC:obol] synonym: "regulation of adaxial/abaxial pattern specification" RELATED [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0009955 ! adaxial/abaxial pattern formation [Term] id: GO:2000012 name: regulation of auxin polar transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of auxin polar transport." [GOC:obol] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0009926 ! auxin polar transport [Term] id: GO:2000013 name: regulation of arginine biosynthetic process via ornithine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine." [GOC:obol] synonym: "regulation of arginine anabolism via ornithine" EXACT [GOC:obol] synonym: "regulation of arginine formation via ornithine" EXACT [GOC:obol] synonym: "regulation of arginine synthesis via ornithine" EXACT [GOC:obol] is_a: GO:0000821 ! regulation of arginine metabolic process is_a: GO:0090368 ! regulation of ornithine metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process relationship: regulates GO:0042450 ! arginine biosynthetic process via ornithine [Term] id: GO:2000014 name: regulation of endosperm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endosperm development." [GOC:obol] is_a: GO:0080050 ! regulation of seed development relationship: regulates GO:0009960 ! endosperm development [Term] id: GO:2000015 name: regulation of determination of dorsal identity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of determination of dorsal identity." [GOC:obol] subset: unvetted synonym: "regulation of determination of adaxial identity" RELATED [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0048263 ! determination of dorsal identity [Term] id: GO:2000016 name: negative regulation of determination of dorsal identity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity." [GOC:obol] subset: unvetted synonym: "negative regulation of determination of adaxial identity" RELATED [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000015 ! regulation of determination of dorsal identity relationship: negatively_regulates GO:0048263 ! determination of dorsal identity [Term] id: GO:2000017 name: positive regulation of determination of dorsal identity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of determination of dorsal identity." [GOC:obol] subset: unvetted synonym: "positive regulation of determination of adaxial identity" RELATED [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000015 ! regulation of determination of dorsal identity relationship: positively_regulates GO:0048263 ! determination of dorsal identity [Term] id: GO:2000018 name: regulation of male gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of male gonad development." [GOC:obol] subset: unvetted synonym: "regulation of testicular development" EXACT [GOC:obol] synonym: "regulation of testis development" EXACT [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0008584 ! male gonad development [Term] id: GO:2000019 name: negative regulation of male gonad development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development." [GOC:obol] subset: unvetted synonym: "negative regulation of testicular development" EXACT [GOC:obol] synonym: "negative regulation of testis development" EXACT [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000018 ! regulation of male gonad development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0008584 ! male gonad development [Term] id: GO:2000020 name: positive regulation of male gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of male gonad development." [GOC:obol] subset: unvetted synonym: "positive regulation of testicular development" EXACT [GOC:obol] synonym: "positive regulation of testis development" EXACT [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000018 ! regulation of male gonad development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0008584 ! male gonad development [Term] id: GO:2000021 name: regulation of ion homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ion homeostasis." [GOC:obol] synonym: "regulation of electrolyte homeostasis" RELATED [GOC:obol] synonym: "regulation of negative regulation of crystal biosynthesis" RELATED [GOC:obol] synonym: "regulation of negative regulation of crystal formation" RELATED [GOC:obol] is_a: GO:0032844 ! regulation of homeostatic process relationship: regulates GO:0050801 ! ion homeostasis [Term] id: GO:2000022 name: regulation of jasmonic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway." [GOC:obol] synonym: "regulation of jasmonic acid mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0009867 ! jasmonic acid mediated signaling pathway [Term] id: GO:2000023 name: regulation of lateral root development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lateral root development." [GOC:obol] is_a: GO:2000069 ! regulation of post-embryonic root development relationship: regulates GO:0048527 ! lateral root development [Term] id: GO:2000024 name: regulation of leaf development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leaf development." [GOC:obol] is_a: GO:0048831 ! regulation of shoot development relationship: regulates GO:0048366 ! leaf development [Term] id: GO:2000025 name: regulation of leaf formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leaf formation." [GOC:obol] is_a: GO:0003156 ! regulation of organ formation is_a: GO:2000024 ! regulation of leaf development relationship: regulates GO:0010338 ! leaf formation [Term] id: GO:2000026 name: regulation of multicellular organismal development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0007275 ! multicellular organismal development [Term] id: GO:2000027 name: regulation of organ morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organ morphogenesis." [GOC:obol] synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0009887 ! organ morphogenesis [Term] id: GO:2000028 name: regulation of photoperiodism, flowering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photoperiodism, flowering." [GOC:obol] synonym: "regulation of photoperiodic control of flowering time" EXACT [GOC:obol] synonym: "regulation of photoperiodic control of inflorescence development" EXACT [GOC:obol] synonym: "regulation of response to day length, flowering" EXACT [GOC:obol] synonym: "regulation of response to night length, flowering" EXACT [GOC:obol] synonym: "regulation of response to photoperiod, flowering" EXACT [GOC:obol] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0048573 ! photoperiodism, flowering [Term] id: GO:2000029 name: regulation of proanthocyanidin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process." [GOC:obol] synonym: "regulation of proanthocyanidin anabolism" EXACT [GOC:obol] synonym: "regulation of proanthocyanidin biosynthesis" EXACT [GOC:obol] synonym: "regulation of proanthocyanidin formation" EXACT [GOC:obol] synonym: "regulation of proanthocyanidin synthesis" EXACT [GOC:obol] is_a: GO:0009962 ! regulation of flavonoid biosynthetic process relationship: regulates GO:0010023 ! proanthocyanidin biosynthetic process [Term] id: GO:2000030 name: regulation of response to red or far red light namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to red or far red light." [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0009639 ! response to red or far red light [Term] id: GO:2000031 name: regulation of salicylic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway." [GOC:obol] synonym: "regulation of salicylic acid mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0009863 ! salicylic acid mediated signaling pathway [Term] id: GO:2000032 name: regulation of secondary shoot formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary shoot formation." [GOC:obol] synonym: "regulation of auxiliary shoot formation" EXACT [GOC:obol] synonym: "regulation of axillary shoot formation" EXACT [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0048831 ! regulation of shoot development relationship: regulates GO:0010223 ! secondary shoot formation [Term] id: GO:2000033 name: regulation of seed dormancy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed dormancy." [GOC:obol] is_a: GO:2000034 ! regulation of seed maturation relationship: regulates GO:0010162 ! seed dormancy [Term] id: GO:2000034 name: regulation of seed maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed maturation." [GOC:obol] is_a: GO:0080050 ! regulation of seed development relationship: regulates GO:0010431 ! seed maturation [Term] id: GO:2000035 name: regulation of stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol] synonym: "regulation of stem cell renewal" EXACT [GOC:obol] is_a: GO:0051302 ! regulation of cell division relationship: regulates GO:0017145 ! stem cell division [Term] id: GO:2000036 name: regulation of stem cell maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell maintenance." [GOC:obol] synonym: "regulation of maintenance of pluripotency" RELATED [GOC:obol] is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0019827 ! stem cell maintenance [Term] id: GO:2000037 name: regulation of stomatal complex patterning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stomatal complex patterning." [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0010375 ! stomatal complex patterning [Term] id: GO:2000038 name: regulation of stomatal complex development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stomatal complex development." [GOC:obol] is_a: GO:0048580 ! regulation of post-embryonic development relationship: regulates GO:0010374 ! stomatal complex development [Term] id: GO:2000039 name: regulation of trichome morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trichome morphogenesis." [GOC:obol] synonym: "regulation of trichome cell morphogenesis during differentiation" EXACT [GOC:obol] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:2000024 ! regulation of leaf development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0010090 ! trichome morphogenesis [Term] id: GO:2000040 name: regulation of planar cell polarity pathway involved in axis elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000095 ! regulation of Wnt receptor signaling pathway, planar cell polarity pathway relationship: regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation [Term] id: GO:2000041 name: negative regulation of planar cell polarity pathway involved in axis elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph] is_a: GO:2000040 ! regulation of planar cell polarity pathway involved in axis elongation is_a: GO:2000051 ! negative regulation of non-canonical Wnt receptor signaling pathway relationship: negatively_regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation [Term] id: GO:2000042 name: negative regulation of double-strand break repair via homologous recombination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw] synonym: "negative regulation of HDR" EXACT [GOC:obol] synonym: "negative regulation of homologous recombinational repair" EXACT [GOC:obol] synonym: "negative regulation of homology-directed repair" EXACT [GOC:obol] synonym: "negative regulation of HRR" EXACT [GOC:obol] synonym: "negative regulation of Rad51-dependent recombinational repair" EXACT [GOC:obol] synonym: "negative regulation of Rhp51-dependent recombinational repair" EXACT [GOC:obol] is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination is_a: GO:0045738 ! negative regulation of DNA repair is_a: GO:0045910 ! negative regulation of DNA recombination relationship: negatively_regulates GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:2000043 name: regulation of cardiac cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0060912 ! cardiac cell fate specification [Term] id: GO:2000044 name: negative regulation of cardiac cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:2000043 ! regulation of cardiac cell fate specification relationship: negatively_regulates GO:0060912 ! cardiac cell fate specification [Term] id: GO:2000045 name: regulation of G1/S transition of mitotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G1/S transition of mitotic cell cycle." [GOC:vw] is_a: GO:2000602 ! regulation of interphase of mitotic cell cycle relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:2000046 name: regulation of G2 phase of mitotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:vw] is_a: GO:2000602 ! regulation of interphase of mitotic cell cycle relationship: regulates GO:0000085 ! G2 phase of mitotic cell cycle [Term] id: GO:2000047 name: regulation of cell-cell adhesion mediated by cadherin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin relationship: regulates GO:0044331 ! cell-cell adhesion mediated by cadherin [Term] id: GO:2000048 name: negative regulation of cell-cell adhesion mediated by cadherin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0033629 ! negative regulation of cell adhesion mediated by integrin is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin relationship: negatively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin [Term] id: GO:2000049 name: positive regulation of cell-cell adhesion mediated by cadherin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0033630 ! positive regulation of cell adhesion mediated by integrin is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin relationship: positively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin [Term] id: GO:2000050 name: regulation of non-canonical Wnt receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-canonical Wnt receptor signaling pathway." [GOC:obol] synonym: "regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] synonym: "regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway relationship: regulates GO:0035567 ! non-canonical Wnt receptor signaling pathway [Term] id: GO:2000051 name: negative regulation of non-canonical Wnt receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt receptor signaling pathway." [GOC:obol] synonym: "negative regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway is_a: GO:2000050 ! regulation of non-canonical Wnt receptor signaling pathway relationship: negatively_regulates GO:0035567 ! non-canonical Wnt receptor signaling pathway [Term] id: GO:2000052 name: positive regulation of non-canonical Wnt receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt receptor signaling pathway." [GOC:obol] synonym: "positive regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0030177 ! positive regulation of Wnt receptor signaling pathway is_a: GO:2000050 ! regulation of non-canonical Wnt receptor signaling pathway relationship: positively_regulates GO:0035567 ! non-canonical Wnt receptor signaling pathway [Term] id: GO:2000053 name: regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt receptor signaling pathway involved in dorsal/ventral axis specification." [GOC:obol] synonym: "regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0044332 ! Wnt receptor signaling pathway involved in dorsal/ventral axis specification [Term] id: GO:2000054 name: negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt receptor signaling pathway involved in dorsal/ventral axis specification." [GOC:obol] synonym: "negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway is_a: GO:2000053 ! regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification relationship: negatively_regulates GO:0044332 ! Wnt receptor signaling pathway involved in dorsal/ventral axis specification [Term] id: GO:2000055 name: positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Wnt receptor signaling pathway involved in dorsal/ventral axis specification." [GOC:obol] synonym: "positive regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] is_a: GO:0030177 ! positive regulation of Wnt receptor signaling pathway is_a: GO:2000053 ! regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification relationship: positively_regulates GO:0044332 ! Wnt receptor signaling pathway involved in dorsal/ventral axis specification [Term] id: GO:2000056 name: regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt receptor signaling pathway involved in digestive tract morphogenesis." [GOC:obol] synonym: "regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0044333 ! Wnt receptor signaling pathway involved in digestive tract morphogenesis [Term] id: GO:2000057 name: negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt receptor signaling pathway involved in digestive tract morphogenesis." [GOC:obol] synonym: "negative regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah] is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway is_a: GO:2000056 ! regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis relationship: negatively_regulates GO:0044333 ! Wnt receptor signaling pathway involved in digestive tract morphogenesis [Term] id: GO:2000058 name: regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF] synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" RELATED [GOC:obol] synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" RELATED [GOC:obol] synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" RELATED [GOC:obol] synonym: "regulation of protein degradation tagging activity" RELATED [GOC:obol] synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [GOC:obol] synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [GOC:obol] synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:0042176 ! regulation of protein catabolic process relationship: regulates GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Term] id: GO:2000059 name: negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF] synonym: "negative regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" RELATED [GOC:obol] synonym: "negative regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] synonym: "negative regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" RELATED [GOC:obol] synonym: "negative regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" RELATED [GOC:obol] synonym: "negative regulation of protein degradation tagging activity" RELATED [GOC:obol] synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [GOC:obol] synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [GOC:obol] synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] is_a: GO:0031397 ! negative regulation of protein ubiquitination is_a: GO:2000058 ! regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process relationship: negatively_regulates GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Term] id: GO:2000060 name: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF] synonym: "positive regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" RELATED [GOC:obol] synonym: "positive regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] synonym: "positive regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" RELATED [GOC:obol] synonym: "positive regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" RELATED [GOC:obol] synonym: "positive regulation of protein degradation tagging activity" RELATED [GOC:obol] synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [GOC:obol] synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [GOC:obol] synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] is_a: GO:0031398 ! positive regulation of protein ubiquitination is_a: GO:2000058 ! regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process relationship: positively_regulates GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Term] id: GO:2000061 name: regulation of ureter smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:obol] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051150 ! regulation of smooth muscle cell differentiation relationship: regulates GO:0072193 ! ureter smooth muscle cell differentiation [Term] id: GO:2000062 name: negative regulation of ureter smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:obol] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation relationship: negatively_regulates GO:0072193 ! ureter smooth muscle cell differentiation [Term] id: GO:2000063 name: positive regulation of ureter smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:obol] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation relationship: positively_regulates GO:0072193 ! ureter smooth muscle cell differentiation [Term] id: GO:2000064 name: regulation of cortisol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol] synonym: "regulation of cortisol anabolism" RELATED [GOC:obol] synonym: "regulation of cortisol biosynthesis" EXACT [GOC:obol] synonym: "regulation of cortisol formation" EXACT [GOC:obol] synonym: "regulation of cortisol synthesis" EXACT [GOC:obol] is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process relationship: regulates GO:0034651 ! cortisol biosynthetic process [Term] id: GO:2000065 name: negative regulation of cortisol biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol] synonym: "negative regulation of cortisol anabolism" RELATED [GOC:obol] synonym: "negative regulation of cortisol biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cortisol formation" EXACT [GOC:obol] synonym: "negative regulation of cortisol synthesis" EXACT [GOC:obol] is_a: GO:0031947 ! negative regulation of glucocorticoid biosynthetic process is_a: GO:2000064 ! regulation of cortisol biosynthetic process relationship: negatively_regulates GO:0034651 ! cortisol biosynthetic process [Term] id: GO:2000066 name: positive regulation of cortisol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol] synonym: "positive regulation of cortisol anabolism" RELATED [GOC:obol] synonym: "positive regulation of cortisol biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of cortisol formation" EXACT [GOC:obol] synonym: "positive regulation of cortisol synthesis" EXACT [GOC:obol] is_a: GO:0031948 ! positive regulation of glucocorticoid biosynthetic process is_a: GO:2000064 ! regulation of cortisol biosynthetic process relationship: positively_regulates GO:0034651 ! cortisol biosynthetic process [Term] id: GO:2000067 name: regulation of root morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of root morphogenesis." [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000280 ! regulation of root development relationship: regulates GO:0010015 ! root morphogenesis [Term] id: GO:2000068 name: regulation of defense response to insect namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol] synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0002213 ! defense response to insect [Term] id: GO:2000069 name: regulation of post-embryonic root development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of post-embryonic root development." [GOC:obol] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000280 ! regulation of root development relationship: regulates GO:0048528 ! post-embryonic root development [Term] id: GO:2000070 name: regulation of response to water deprivation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to water deprivation." [GOC:obol] synonym: "regulation of drought tolerance" RELATED [GOC:obol] synonym: "regulation of response to dehydration" EXACT [GOC:obol] synonym: "regulation of response to drought" EXACT [GOC:obol] synonym: "regulation of response to thirst" EXACT [GOC:obol] is_a: GO:0080134 ! regulation of response to stress relationship: regulates GO:0009414 ! response to water deprivation [Term] id: GO:2000071 name: regulation of defense response by callose deposition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response by callose deposition." [GOC:obol] synonym: "regulation of callose deposition during defense response" RELATED [GOC:obol] synonym: "regulation of callose localization during defense response" RELATED [GOC:obol] is_a: GO:0031347 ! regulation of defense response is_a: GO:0032879 ! regulation of localization relationship: regulates GO:0052542 ! defense response by callose deposition [Term] id: GO:2000072 name: regulation of defense response to fungus, incompatible interaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to fungus, incompatible interaction." [GOC:obol] synonym: "regulation of defence response to fungus, incompatible interaction" EXACT [GOC:obol] synonym: "regulation of defence response to pathogenic fungi, incompatible interaction" EXACT [GOC:obol] synonym: "regulation of defence response to pathogenic fungus, incompatible interaction" EXACT [GOC:obol] synonym: "regulation of defense response to fungi, incompatible interaction" EXACT [GOC:obol] synonym: "regulation of resistance response to pathogenic fungi" EXACT [GOC:obol] synonym: "regulation of resistance response to pathogenic fungus" EXACT [GOC:obol] synonym: "regulation of response to pathogenic fungi (incompatible interaction)" EXACT [GOC:obol] synonym: "regulation of response to pathogenic fungus (incompatible interaction)" EXACT [GOC:obol] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0009817 ! defense response to fungus, incompatible interaction [Term] id: GO:2000073 name: regulation of site selection involved in cell cycle cytokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of site selection involved in cell cycle cytokinesis." [GOC:obol] is_a: GO:0032954 ! regulation of cytokinetic process is_a: GO:0071775 ! regulation of cell cycle cytokinesis relationship: regulates GO:0010687 ! site selection involved in cell cycle cytokinesis [Term] id: GO:2000074 name: regulation of type B pancreatic cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol] synonym: "regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0060284 ! regulation of cell development is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0003323 ! type B pancreatic cell development [Term] id: GO:2000075 name: negative regulation of site selection involved in cell cycle cytokinesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of site selection involved in cell cycle cytokinesis." [GOC:obol] is_a: GO:0071776 ! negative regulation of cell cycle cytokinesis is_a: GO:2000073 ! regulation of site selection involved in cell cycle cytokinesis relationship: negatively_regulates GO:0010687 ! site selection involved in cell cycle cytokinesis [Term] id: GO:2000076 name: positive regulation of site selection involved in cell cycle cytokinesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of site selection involved in cell cycle cytokinesis." [GOC:obol] is_a: GO:0071777 ! positive regulation of cell cycle cytokinesis is_a: GO:2000073 ! regulation of site selection involved in cell cycle cytokinesis relationship: positively_regulates GO:0010687 ! site selection involved in cell cycle cytokinesis [Term] id: GO:2000077 name: negative regulation of type B pancreatic cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol] synonym: "negative regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "negative regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:2000074 ! regulation of type B pancreatic cell development relationship: negatively_regulates GO:0003323 ! type B pancreatic cell development [Term] id: GO:2000078 name: positive regulation of type B pancreatic cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol] synonym: "positive regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "positive regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:2000074 ! regulation of type B pancreatic cell development relationship: positively_regulates GO:0003323 ! type B pancreatic cell development [Term] id: GO:2000079 name: regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of canonical Wnt receptor signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol] synonym: "regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol] synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0060828 ! regulation of canonical Wnt receptor signaling pathway relationship: regulates GO:0044343 ! canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation [Term] id: GO:2000080 name: negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt receptor signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah] is_a: GO:0090090 ! negative regulation of canonical Wnt receptor signaling pathway is_a: GO:2000079 ! regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation relationship: negatively_regulates GO:0044343 ! canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation [Term] id: GO:2000081 name: positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt receptor signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah] is_a: GO:0090263 ! positive regulation of canonical Wnt receptor signaling pathway is_a: GO:2000079 ! regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation relationship: positively_regulates GO:0044343 ! canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation [Term] id: GO:2000082 name: regulation of L-ascorbic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407] synonym: "regulation of ascorbate biosynthesis" EXACT [GOC:obol] synonym: "regulation of ascorbate biosynthetic process" EXACT [GOC:obol] synonym: "regulation of L-ascorbic acid anabolism" EXACT [GOC:obol] synonym: "regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of L-ascorbic acid formation" EXACT [GOC:obol] synonym: "regulation of L-ascorbic acid synthesis" EXACT [GOC:obol] synonym: "regulation of vitamin C biosynthesis" EXACT [GOC:obol] synonym: "regulation of vitamin C biosynthetic process" EXACT [GOC:obol] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0019853 ! L-ascorbic acid biosynthetic process [Term] id: GO:2000083 name: negative regulation of L-ascorbic acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407] synonym: "negative regulation of ascorbate biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of ascorbate biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of L-ascorbic acid anabolism" EXACT [GOC:obol] synonym: "negative regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of L-ascorbic acid formation" EXACT [GOC:obol] synonym: "negative regulation of L-ascorbic acid synthesis" EXACT [GOC:obol] synonym: "negative regulation of vitamin C biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of vitamin C biosynthetic process" EXACT [GOC:obol] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:2000082 ! regulation of L-ascorbic acid biosynthetic process relationship: negatively_regulates GO:0019853 ! L-ascorbic acid biosynthetic process [Term] id: GO:2000084 name: regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] synonym: "regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis [Term] id: GO:2000085 name: negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] synonym: "negative regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis relationship: negatively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis [Term] id: GO:2000086 name: positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] synonym: "positive regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis relationship: positively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis [Term] id: GO:2000087 name: regulation of mesonephric glomerulus development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0090192 ! regulation of glomerulus development relationship: regulates GO:0061224 ! mesonephric glomerulus development [Term] id: GO:2000088 name: negative regulation of mesonephric glomerulus development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] is_a: GO:0090194 ! negative regulation of glomerulus development is_a: GO:2000087 ! regulation of mesonephric glomerulus development relationship: negatively_regulates GO:0061224 ! mesonephric glomerulus development [Term] id: GO:2000089 name: positive regulation of mesonephric glomerulus development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] is_a: GO:0090193 ! positive regulation of glomerulus development is_a: GO:2000087 ! regulation of mesonephric glomerulus development relationship: positively_regulates GO:0061224 ! mesonephric glomerulus development [Term] id: GO:2000090 name: regulation of mesonephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation is_a: GO:2000087 ! regulation of mesonephric glomerulus development is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development relationship: regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development [Term] id: GO:2000091 name: negative regulation of mesonephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation is_a: GO:2000607 ! negative regulation of cell proliferation involved in mesonephros development relationship: negatively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development [Term] id: GO:2000092 name: positive regulation of mesonephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation is_a: GO:2000608 ! positive regulation of cell proliferation involved in mesonephros development relationship: positively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development [Term] id: GO:2000093 name: regulation of mesonephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation relationship: regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation [Term] id: GO:2000094 name: negative regulation of mesonephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation is_a: GO:2000093 ! regulation of mesonephric nephron tubule epithelial cell differentiation relationship: negatively_regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation [Term] id: GO:2000095 name: regulation of Wnt receptor signaling pathway, planar cell polarity pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt receptor signaling pathway, planar cell polarity pathway." [GOC:BHF] synonym: "regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol] synonym: "regulation of PCP pathway" EXACT [GOC:obol] synonym: "regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol] synonym: "regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol] synonym: "regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol] is_a: GO:2000050 ! regulation of non-canonical Wnt receptor signaling pathway relationship: regulates GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway [Term] id: GO:2000096 name: positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Wnt receptor signaling pathway, planar cell polarity pathway." [GOC:BHF] synonym: "positive regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of PCP pathway" EXACT [GOC:obol] synonym: "positive regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol] synonym: "positive regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol] is_a: GO:2000052 ! positive regulation of non-canonical Wnt receptor signaling pathway is_a: GO:2000095 ! regulation of Wnt receptor signaling pathway, planar cell polarity pathway relationship: positively_regulates GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway [Term] id: GO:2000097 name: regulation of smooth muscle cell-matrix adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF] is_a: GO:0001952 ! regulation of cell-matrix adhesion relationship: regulates GO:0061302 ! smooth muscle cell-matrix adhesion [Term] id: GO:2000098 name: negative regulation of smooth muscle cell-matrix adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF] is_a: GO:0001953 ! negative regulation of cell-matrix adhesion is_a: GO:2000097 ! regulation of smooth muscle cell-matrix adhesion relationship: negatively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion [Term] id: GO:2000099 name: regulation of establishment or maintenance of bipolar cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity." [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity relationship: regulates GO:0061245 ! establishment or maintenance of bipolar cell polarity [Term] id: GO:2000100 name: regulation of establishment or maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol] is_a: GO:2000099 ! regulation of establishment or maintenance of bipolar cell polarity relationship: regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape [Term] id: GO:2000101 name: regulation of mammary stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0002174 ! mammary stem cell proliferation [Term] id: GO:2000102 name: negative regulation of mammary stem cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:2000101 ! regulation of mammary stem cell proliferation relationship: negatively_regulates GO:0002174 ! mammary stem cell proliferation [Term] id: GO:2000103 name: positive regulation of mammary stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:2000101 ! regulation of mammary stem cell proliferation relationship: positively_regulates GO:0002174 ! mammary stem cell proliferation [Term] id: GO:2000104 name: negative regulation of DNA-dependent DNA replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah] is_a: GO:0008156 ! negative regulation of DNA replication is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: negatively_regulates GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:2000105 name: positive regulation of DNA-dependent DNA replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah] is_a: GO:0045740 ! positive regulation of DNA replication is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: positively_regulates GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:2000106 name: regulation of leukocyte apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte apoptosis." [GOC:BHF] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0071887 ! leukocyte apoptosis [Term] id: GO:2000107 name: negative regulation of leukocyte apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptosis." [GOC:BHF] is_a: GO:0043066 ! negative regulation of apoptosis is_a: GO:2000106 ! regulation of leukocyte apoptosis relationship: negatively_regulates GO:0071887 ! leukocyte apoptosis [Term] id: GO:2000108 name: positive regulation of leukocyte apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptosis." [GOC:BHF] is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:2000106 ! regulation of leukocyte apoptosis relationship: positively_regulates GO:0071887 ! leukocyte apoptosis [Term] id: GO:2000109 name: regulation of macrophage apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage apoptosis." [GOC:BHF] is_a: GO:2000106 ! regulation of leukocyte apoptosis relationship: regulates GO:0071888 ! macrophage apoptosis [Term] id: GO:2000110 name: negative regulation of macrophage apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptosis." [GOC:BHF] is_a: GO:2000107 ! negative regulation of leukocyte apoptosis is_a: GO:2000109 ! regulation of macrophage apoptosis relationship: negatively_regulates GO:0071888 ! macrophage apoptosis [Term] id: GO:2000111 name: positive regulation of macrophage apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptosis." [GOC:BHF] is_a: GO:2000108 ! positive regulation of leukocyte apoptosis is_a: GO:2000109 ! regulation of macrophage apoptosis relationship: positively_regulates GO:0071888 ! macrophage apoptosis [Term] id: GO:2000112 name: regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:2000113 name: negative regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "negative regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:2000114 name: regulation of establishment of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol] synonym: "regulation of cell polarization" EXACT [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity relationship: regulates GO:0030010 ! establishment of cell polarity [Term] id: GO:2000115 name: regulation of maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape." [GOC:obol] is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape relationship: regulates GO:0061305 ! maintenance of bipolar cell polarity regulating in cell shape [Term] id: GO:2000116 name: regulation of cysteine-type endopeptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol] synonym: "regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] synonym: "regulation of thiol endopeptidase activity" EXACT [GOC:obol] is_a: GO:0052548 ! regulation of endopeptidase activity [Term] id: GO:2000117 name: negative regulation of cysteine-type endopeptidase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol] synonym: "negative regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] synonym: "negative regulation of thiol endopeptidase activity" EXACT [GOC:obol] is_a: GO:0010951 ! negative regulation of endopeptidase activity is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity [Term] id: GO:2000118 name: regulation of sodium-dependent phosphate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF] is_a: GO:0010966 ! regulation of phosphate transport relationship: regulates GO:0044341 ! sodium-dependent phosphate transport [Term] id: GO:2000119 name: negative regulation of sodium-dependent phosphate transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport relationship: negatively_regulates GO:0044341 ! sodium-dependent phosphate transport [Term] id: GO:2000120 name: positive regulation of sodium-dependent phosphate transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport relationship: positively_regulates GO:0044341 ! sodium-dependent phosphate transport [Term] id: GO:2000121 name: regulation of removal of superoxide radicals namespace: biological_process def: "Any process that modulates the frequency, rate or extent of removal of superoxide radicals." [GOC:obol] synonym: "regulation of removal of O2-" EXACT [GOC:obol] synonym: "regulation of removal of oxygen free radicals" EXACT [GOC:obol] is_a: GO:0080135 ! regulation of cellular response to stress is_a: GO:0090322 ! regulation of superoxide metabolic process relationship: regulates GO:0019430 ! removal of superoxide radicals [Term] id: GO:2000122 name: negative regulation of stomatal complex development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of stomatal complex development." [GOC:obol] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:2000038 ! regulation of stomatal complex development relationship: negatively_regulates GO:0010374 ! stomatal complex development [Term] id: GO:2000123 name: positive regulation of stomatal complex development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stomatal complex development." [GOC:obol] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:2000038 ! regulation of stomatal complex development relationship: positively_regulates GO:0010374 ! stomatal complex development [Term] id: GO:2000124 name: regulation of endocannabinoid signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway." [GOC:mah, PMID:15550444] synonym: "regulation of endocannabinoid signalling pathway" EXACT [GOC:obol] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway relationship: regulates GO:0071926 ! endocannabinoid signaling pathway [Term] id: GO:2000125 name: regulation of octopamine or tyramine signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah] synonym: "regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol] synonym: "regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway relationship: regulates GO:0007211 ! octopamine or tyramine signaling pathway [Term] id: GO:2000126 name: negative regulation of octopamine or tyramine signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah] synonym: "negative regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol] synonym: "negative regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol] is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway relationship: negatively_regulates GO:0007211 ! octopamine or tyramine signaling pathway [Term] id: GO:2000127 name: positive regulation of octopamine or tyramine signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah] synonym: "positive regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol] synonym: "positive regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol] is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway relationship: positively_regulates GO:0007211 ! octopamine or tyramine signaling pathway [Term] id: GO:2000128 name: regulation of octopamine signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway." [GOC:mah] synonym: "regulation of octopamine signalling pathway" EXACT [GOC:obol] is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway relationship: regulates GO:0071927 ! octopamine signaling pathway [Term] id: GO:2000129 name: negative regulation of octopamine signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway." [GOC:mah] synonym: "negative regulation of octopamine signalling pathway" EXACT [GOC:obol] is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway is_a: GO:2000128 ! regulation of octopamine signaling pathway relationship: negatively_regulates GO:0071927 ! octopamine signaling pathway [Term] id: GO:2000130 name: positive regulation of octopamine signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway." [GOC:mah] synonym: "positive regulation of octopamine signalling pathway" EXACT [GOC:obol] is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway is_a: GO:2000128 ! regulation of octopamine signaling pathway relationship: positively_regulates GO:0071927 ! octopamine signaling pathway [Term] id: GO:2000131 name: regulation of tyramine signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tyramine signaling pathway." [GOC:mah] synonym: "regulation of tyramine signalling pathway" EXACT [GOC:obol] is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway relationship: regulates GO:0071928 ! tyramine signaling pathway [Term] id: GO:2000132 name: negative regulation of tyramine signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tyramine signaling pathway." [GOC:mah] synonym: "negative regulation of tyramine signalling pathway" EXACT [GOC:obol] is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway is_a: GO:2000131 ! regulation of tyramine signaling pathway relationship: negatively_regulates GO:0071928 ! tyramine signaling pathway [Term] id: GO:2000133 name: positive regulation of tyramine signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tyramine signaling pathway." [GOC:mah] synonym: "positive regulation of tyramine signalling pathway" EXACT [GOC:obol] is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway is_a: GO:2000131 ! regulation of tyramine signaling pathway relationship: positively_regulates GO:0071928 ! tyramine signaling pathway [Term] id: GO:2000134 name: negative regulation of G1/S transition of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G1/S transition of mitotic cell cycle." [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle relationship: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:2000135 name: positive regulation of regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of secondary heart field cardioblast proliferation." [GOC:dph] comment: This term was made obsolete because it makes no sense and was added in error. synonym: "positive regulation of regulation of second heart field cardioblast proliferation" EXACT [GOC:obol] is_obsolete: true [Term] id: GO:2000136 name: regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis [Term] id: GO:2000137 name: negative regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis relationship: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis [Term] id: GO:2000138 name: positive regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis relationship: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis [Term] id: GO:2000139 name: regulation of octopamine signaling pathway involved in response to food namespace: biological_process def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300] synonym: "regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah] is_a: GO:0032095 ! regulation of response to food is_a: GO:2000128 ! regulation of octopamine signaling pathway relationship: regulates GO:0071935 ! octopamine signaling pathway involved in response to food [Term] id: GO:2000140 name: negative regulation of octopamine signaling pathway involved in response to food namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300] synonym: "negative regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah] is_a: GO:0032096 ! negative regulation of response to food is_a: GO:2000129 ! negative regulation of octopamine signaling pathway is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food relationship: negatively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food [Term] id: GO:2000141 name: positive regulation of octopamine signaling pathway involved in response to food namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300] synonym: "positive regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah] is_a: GO:0032097 ! positive regulation of response to food is_a: GO:2000130 ! positive regulation of octopamine signaling pathway is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food relationship: positively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food [Term] id: GO:2000142 name: regulation of transcription initiation, DNA-dependent namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA-dependent transcription initiation." [GOC:mah, GOC:txnOH] synonym: "regulation of DNA-dependent RNA polymerase complex assembly at promoter" EXACT [GOC:obol] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0043254 ! regulation of protein complex assembly relationship: regulates GO:0006352 ! transcription initiation, DNA-dependent [Term] id: GO:2000143 name: negative regulation of transcription initiation, DNA-dependent namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription initiation." [GOC:mah, GOC:txnOH] synonym: "negative regulation of DNA-dependent RNA polymerase complex assembly at promoter" EXACT [GOC:obol] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000142 ! regulation of transcription initiation, DNA-dependent relationship: negatively_regulates GO:0006352 ! transcription initiation, DNA-dependent [Term] id: GO:2000144 name: positive regulation of transcription initiation, DNA-dependent namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription initiation." [GOC:mah, GOC:txnOH] synonym: "positive regulation of DNA-dependent RNA polymerase complex assembly at promoter" EXACT [GOC:obol] synonym: "transactivation" RELATED [PMID:11158542] synonym: "transcriptional transactivation" RELATED [PMID:11580863] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2000142 ! regulation of transcription initiation, DNA-dependent relationship: positively_regulates GO:0006352 ! transcription initiation, DNA-dependent [Term] id: GO:2000145 name: regulation of cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] synonym: "regulation of cell locomotion" EXACT [GOC:obol] synonym: "regulation of cell movement" RELATED [GOC:obol] synonym: "regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0051270 ! regulation of cellular component movement relationship: regulates GO:0048870 ! cell motility [Term] id: GO:2000146 name: negative regulation of cell motility namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] synonym: "negative regulation of cell locomotion" EXACT [GOC:obol] synonym: "negative regulation of cell movement" RELATED [GOC:obol] synonym: "negative regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility relationship: negatively_regulates GO:0048870 ! cell motility [Term] id: GO:2000147 name: positive regulation of cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] synonym: "positive regulation of cell locomotion" EXACT [GOC:obol] synonym: "positive regulation of cell movement" RELATED [GOC:obol] synonym: "positive regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility relationship: positively_regulates GO:0048870 ! cell motility [Term] id: GO:2000148 name: regulation of planar cell polarity pathway involved in ventricular septum morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph] is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis relationship: regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis [Term] id: GO:2000149 name: negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph] is_a: GO:2000148 ! regulation of planar cell polarity pathway involved in ventricular septum morphogenesis is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis relationship: negatively_regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis [Term] id: GO:2000150 name: regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph] is_a: GO:0055024 ! regulation of cardiac muscle tissue development is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis relationship: regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [Term] id: GO:2000151 name: negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph] is_a: GO:2000150 ! regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis relationship: negatively_regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [Term] id: GO:2000152 name: regulation of ubiquitin-specific protease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquitin-specific protease activity." [GOC:obol] synonym: "regulation of ubiquitin hydrolase activity" EXACT [GOC:obol] synonym: "regulation of UBP" RELATED [GOC:obol] synonym: "regulation of UCH2" RELATED [GOC:obol] is_a: GO:0052547 ! regulation of peptidase activity [Term] id: GO:2000153 name: regulation of flagellar cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flagellar cell motility." [GOC:mah] is_a: GO:2000145 ! regulation of cell motility relationship: regulates GO:0060286 ! flagellar cell motility [Term] id: GO:2000154 name: negative regulation of flagellar cell motility namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of flagellar cell motility." [GOC:mah] is_a: GO:2000146 ! negative regulation of cell motility is_a: GO:2000153 ! regulation of flagellar cell motility relationship: negatively_regulates GO:0060286 ! flagellar cell motility [Term] id: GO:2000155 name: positive regulation of flagellar cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flagellar cell motility." [GOC:mah] is_a: GO:2000147 ! positive regulation of cell motility is_a: GO:2000153 ! regulation of flagellar cell motility relationship: positively_regulates GO:0060286 ! flagellar cell motility [Term] id: GO:2000156 name: regulation of retrograde vesicle-mediated transport, Golgi to ER namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER." [GOC:mah] synonym: "regulation of cis-Golgi to rough endoplasmic reticulum transport" EXACT [GOC:obol] synonym: "regulation of cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [GOC:obol] synonym: "regulation of cis-Golgi to rough ER transport" EXACT [GOC:obol] synonym: "regulation of cis-Golgi to rough ER vesicle-mediated transport" EXACT [GOC:obol] synonym: "regulation of retrograde (Golgi to ER) transport" EXACT [GOC:obol] synonym: "regulation of retrograde transport, Golgi to endoplasmic reticulum" EXACT [GOC:obol] synonym: "regulation of retrograde transport, Golgi to ER" EXACT [GOC:obol] synonym: "regulation of retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [GOC:obol] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0006890 ! retrograde vesicle-mediated transport, Golgi to ER [Term] id: GO:2000157 name: negative regulation of ubiquitin-specific protease activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease activity." [GOC:obol] synonym: "negative regulation of ubiquitin hydrolase activity" EXACT [GOC:obol] synonym: "negative regulation of UBP" RELATED [GOC:obol] synonym: "negative regulation of UCH2" RELATED [GOC:obol] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity [Term] id: GO:2000158 name: positive regulation of ubiquitin-specific protease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease activity." [GOC:obol] synonym: "positive regulation of ubiquitin hydrolase activity" EXACT [GOC:obol] synonym: "positive regulation of UBP" RELATED [GOC:obol] synonym: "positive regulation of UCH2" RELATED [GOC:obol] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity [Term] id: GO:2000159 name: regulation of planar cell polarity pathway involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph] is_a: GO:0003307 ! regulation of Wnt receptor signaling pathway involved in heart development is_a: GO:2000027 ! regulation of organ morphogenesis is_a: GO:2000095 ! regulation of Wnt receptor signaling pathway, planar cell polarity pathway relationship: regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis [Term] id: GO:2000160 name: negative regulation of planar cell polarity pathway involved in heart morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph] is_a: GO:0003308 ! negative regulation of Wnt receptor signaling pathway involved in heart development is_a: GO:2000051 ! negative regulation of non-canonical Wnt receptor signaling pathway is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis relationship: negatively_regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis [Term] id: GO:2000161 name: regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph] is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis relationship: regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis [Term] id: GO:2000162 name: negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph] is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis is_a: GO:2000161 ! regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis relationship: negatively_regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis [Term] id: GO:2000163 name: regulation of planar cell polarity pathway involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph] is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis relationship: regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis [Term] id: GO:2000164 name: negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph] is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis is_a: GO:2000163 ! regulation of planar cell polarity pathway involved in outflow tract morphogenesis relationship: negatively_regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis [Term] id: GO:2000165 name: regulation of planar cell polarity pathway involved in pericardium morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis relationship: regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis [Term] id: GO:2000166 name: negative regulation of planar cell polarity pathway involved in pericardium morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph] is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis is_a: GO:2000165 ! regulation of planar cell polarity pathway involved in pericardium morphogenesis relationship: negatively_regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis [Term] id: GO:2000167 name: regulation of planar cell polarity pathway involved in neural tube closure namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051960 ! regulation of nervous system development is_a: GO:2000095 ! regulation of Wnt receptor signaling pathway, planar cell polarity pathway relationship: regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure [Term] id: GO:2000168 name: negative regulation of planar cell polarity pathway involved in neural tube closure namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph] is_a: GO:2000051 ! negative regulation of non-canonical Wnt receptor signaling pathway is_a: GO:2000167 ! regulation of planar cell polarity pathway involved in neural tube closure relationship: negatively_regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure [Term] id: GO:2000169 name: regulation of peptidyl-cysteine S-nitrosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation [Term] id: GO:2000170 name: positive regulation of peptidyl-cysteine S-nitrosylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:2000169 ! regulation of peptidyl-cysteine S-nitrosylation relationship: positively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation [Term] id: GO:2000171 name: negative regulation of dendrite development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development." [GOC:obol] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0050773 ! regulation of dendrite development is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0016358 ! dendrite development [Term] id: GO:2000172 name: regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060688 ! regulation of morphogenesis of a branching structure relationship: regulates GO:0048755 ! branching morphogenesis of a nerve [Term] id: GO:2000173 name: negative regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve relationship: negatively_regulates GO:0048755 ! branching morphogenesis of a nerve [Term] id: GO:2000174 name: regulation of pro-T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "regulation of pro-T lymphocyte differentiation " EXACT [GOC:obol] is_a: GO:0045580 ! regulation of T cell differentiation relationship: regulates GO:0002572 ! pro-T cell differentiation [Term] id: GO:2000175 name: negative regulation of pro-T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "negative regulation of pro-T lymphocyte differentiation " EXACT [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation relationship: negatively_regulates GO:0002572 ! pro-T cell differentiation [Term] id: GO:2000176 name: positive regulation of pro-T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "positive regulation of pro-T lymphocyte differentiation " EXACT [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation relationship: positively_regulates GO:0002572 ! pro-T cell differentiation [Term] id: GO:2000177 name: regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0061351 ! neural precursor cell proliferation [Term] id: GO:2000178 name: negative regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation relationship: negatively_regulates GO:0061351 ! neural precursor cell proliferation [Term] id: GO:2000179 name: positive regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation relationship: positively_regulates GO:0061351 ! neural precursor cell proliferation [Term] id: GO:2000180 name: negative regulation of androgen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process." [GOC:dph] synonym: "negative regulation of androgen anabolism" EXACT [GOC:obol] synonym: "negative regulation of androgen biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of androgen formation" EXACT [GOC:obol] synonym: "negative regulation of androgen synthesis" EXACT [GOC:obol] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process relationship: negatively_regulates GO:0006702 ! androgen biosynthetic process [Term] id: GO:2000181 name: negative regulation of blood vessel morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000026 ! regulation of multicellular organismal development relationship: negatively_regulates GO:0048514 ! blood vessel morphogenesis [Term] id: GO:2000182 name: regulation of progesterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] synonym: "regulation of progesterone anabolism" EXACT [GOC:obol] synonym: "regulation of progesterone biosynthesis" EXACT [GOC:obol] synonym: "regulation of progesterone formation" EXACT [GOC:obol] synonym: "regulation of progesterone synthesis" EXACT [GOC:obol] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process relationship: regulates GO:0006701 ! progesterone biosynthetic process [Term] id: GO:2000183 name: negative regulation of progesterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] synonym: "negative regulation of progesterone anabolism" EXACT [GOC:obol] synonym: "negative regulation of progesterone biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of progesterone formation" EXACT [GOC:obol] synonym: "negative regulation of progesterone synthesis" EXACT [GOC:obol] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:2000182 ! regulation of progesterone biosynthetic process relationship: negatively_regulates GO:0006701 ! progesterone biosynthetic process [Term] id: GO:2000184 name: positive regulation of progesterone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] synonym: "positive regulation of progesterone anabolism" EXACT [GOC:obol] synonym: "positive regulation of progesterone biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of progesterone formation" EXACT [GOC:obol] synonym: "positive regulation of progesterone synthesis" EXACT [GOC:obol] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:2000182 ! regulation of progesterone biosynthetic process relationship: positively_regulates GO:0006701 ! progesterone biosynthetic process [Term] id: GO:2000185 name: regulation of phosphate transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] is_a: GO:0010966 ! regulation of phosphate transport is_a: GO:0034765 ! regulation of ion transmembrane transport relationship: regulates GO:0035435 ! phosphate transmembrane transport [Term] id: GO:2000186 name: negative regulation of phosphate transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] is_a: GO:0034766 ! negative regulation of ion transmembrane transport is_a: GO:2000185 ! regulation of phosphate transmembrane transport relationship: negatively_regulates GO:0035435 ! phosphate transmembrane transport [Term] id: GO:2000187 name: positive regulation of phosphate transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] is_a: GO:0034767 ! positive regulation of ion transmembrane transport is_a: GO:2000185 ! regulation of phosphate transmembrane transport relationship: positively_regulates GO:0035435 ! phosphate transmembrane transport [Term] id: GO:2000188 name: regulation of cholesterol homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholesterol homeostasis." [GOC:BHF] is_a: GO:0032844 ! regulation of homeostatic process relationship: regulates GO:0042632 ! cholesterol homeostasis [Term] id: GO:2000189 name: positive regulation of cholesterol homeostasis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cholesterol homeostasis." [GOC:BHF] is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:2000188 ! regulation of cholesterol homeostasis relationship: positively_regulates GO:0042632 ! cholesterol homeostasis [Term] id: GO:2000190 name: negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor." [GOC:BHF] comment: This term was made obsolete because it makes no sense and was added in error. is_obsolete: true replaced_by: GO:0072500 [Term] id: GO:2000191 name: regulation of fatty acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fatty acid transport." [GOC:BHF] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032890 ! regulation of organic acid transport relationship: regulates GO:0015908 ! fatty acid transport [Term] id: GO:2000192 name: negative regulation of fatty acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport." [GOC:BHF] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:2000191 ! regulation of fatty acid transport relationship: negatively_regulates GO:0015908 ! fatty acid transport [Term] id: GO:2000193 name: positive regulation of fatty acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fatty acid transport." [GOC:BHF] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:2000191 ! regulation of fatty acid transport relationship: positively_regulates GO:0015908 ! fatty acid transport [Term] id: GO:2000194 name: regulation of female gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "regulation of ovarian development" EXACT [GOC:obol] synonym: "regulation of ovary development" EXACT [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0008585 ! female gonad development [Term] id: GO:2000195 name: negative regulation of female gonad development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "negative regulation of ovarian development" EXACT [GOC:obol] synonym: "negative regulation of ovary development" EXACT [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000194 ! regulation of female gonad development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0008585 ! female gonad development [Term] id: GO:2000196 name: positive regulation of female gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "positive regulation of ovarian development" EXACT [GOC:obol] synonym: "positive regulation of ovary development" EXACT [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000194 ! regulation of female gonad development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0008585 ! female gonad development [Term] id: GO:2000197 name: regulation of ribonucleoprotein complex localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] synonym: "regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "regulation of RNP localization" EXACT [GOC:obol] is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0071166 ! ribonucleoprotein complex localization [Term] id: GO:2000198 name: negative regulation of ribonucleoprotein complex localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] synonym: "negative regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "negative regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "negative regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "negative regulation of RNP localization" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization relationship: negatively_regulates GO:0071166 ! ribonucleoprotein complex localization [Term] id: GO:2000199 name: positive regulation of ribonucleoprotein complex localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] synonym: "positive regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "positive regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "positive regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "positive regulation of RNP localization" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization relationship: positively_regulates GO:0071166 ! ribonucleoprotein complex localization [Term] id: GO:2000200 name: regulation of ribosomal subunit export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah] synonym: "regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol] synonym: "regulation of ribosome export from nucleus" RELATED [GOC:obol] is_a: GO:0046822 ! regulation of nucleocytoplasmic transport is_a: GO:0090069 ! regulation of ribosome biogenesis is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization relationship: regulates GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:2000201 name: negative regulation of ribosomal subunit export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah] synonym: "negative regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "negative regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol] synonym: "negative regulation of ribosome export from nucleus" RELATED [GOC:obol] is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus relationship: negatively_regulates GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:2000202 name: positive regulation of ribosomal subunit export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah] synonym: "positive regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "positive regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol] synonym: "positive regulation of ribosome export from nucleus" RELATED [GOC:obol] is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus relationship: positively_regulates GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:2000203 name: regulation of ribosomal large subunit export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah] synonym: "regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus relationship: regulates GO:0000055 ! ribosomal large subunit export from nucleus [Term] id: GO:2000204 name: negative regulation of ribosomal large subunit export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah] synonym: "negative regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "negative regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "negative regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "negative regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus relationship: negatively_regulates GO:0000055 ! ribosomal large subunit export from nucleus [Term] id: GO:2000205 name: positive regulation of ribosomal large subunit export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah] synonym: "positive regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "positive regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "positive regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "positive regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus relationship: positively_regulates GO:0000055 ! ribosomal large subunit export from nucleus [Term] id: GO:2000206 name: regulation of ribosomal small subunit export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah] synonym: "regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus relationship: regulates GO:0000056 ! ribosomal small subunit export from nucleus [Term] id: GO:2000207 name: negative regulation of ribosomal small subunit export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah] synonym: "negative regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "negative regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "negative regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "negative regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus relationship: negatively_regulates GO:0000056 ! ribosomal small subunit export from nucleus [Term] id: GO:2000208 name: positive regulation of ribosomal small subunit export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah] synonym: "positive regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "positive regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "positive regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "positive regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus relationship: positively_regulates GO:0000056 ! ribosomal small subunit export from nucleus [Term] id: GO:2000209 name: regulation of anoikis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anoikis." [GOC:mah] synonym: "regulation of detachment induced cell death" EXACT [GOC:obol] synonym: "regulation of suspension induced apoptosis" EXACT [GOC:obol] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0043276 ! anoikis [Term] id: GO:2000210 name: positive regulation of anoikis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anoikis." [GOC:mah] synonym: "positive regulation of detachment induced cell death" EXACT [GOC:obol] synonym: "positive regulation of suspension induced apoptosis" EXACT [GOC:obol] is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:2000209 ! regulation of anoikis relationship: positively_regulates GO:0043276 ! anoikis [Term] id: GO:2000211 name: regulation of glutamate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process relationship: regulates GO:0006536 ! glutamate metabolic process [Term] id: GO:2000212 name: negative regulation of glutamate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "negative regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "negative regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "negative regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:2000211 ! regulation of glutamate metabolic process relationship: negatively_regulates GO:0006536 ! glutamate metabolic process [Term] id: GO:2000213 name: positive regulation of glutamate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "positive regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "positive regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "positive regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:2000211 ! regulation of glutamate metabolic process relationship: positively_regulates GO:0006536 ! glutamate metabolic process [Term] id: GO:2000214 name: regulation of proline metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proline metabolic process." [GOC:sl] synonym: "regulation of proline metabolism" EXACT [GOC:obol] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process relationship: regulates GO:0006560 ! proline metabolic process [Term] id: GO:2000215 name: negative regulation of proline metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process." [GOC:sl] synonym: "negative regulation of proline metabolism" EXACT [GOC:obol] is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:2000214 ! regulation of proline metabolic process relationship: negatively_regulates GO:0006560 ! proline metabolic process [Term] id: GO:2000216 name: positive regulation of proline metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proline metabolic process." [GOC:sl] synonym: "positive regulation of proline metabolism" EXACT [GOC:obol] is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:2000214 ! regulation of proline metabolic process relationship: positively_regulates GO:0006560 ! proline metabolic process [Term] id: GO:2000217 name: regulation of invasive growth in response to glucose limitation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah] synonym: "regulation of colony morphology" RELATED [GOC:obol] is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells relationship: regulates GO:0001403 ! invasive growth in response to glucose limitation [Term] id: GO:2000218 name: negative regulation of invasive growth in response to glucose limitation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah] synonym: "negative regulation of colony morphology" RELATED [GOC:obol] is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation relationship: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation [Term] id: GO:2000219 name: positive regulation of invasive growth in response to glucose limitation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah] synonym: "positive regulation of colony morphology" RELATED [GOC:obol] is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation relationship: positively_regulates GO:0001403 ! invasive growth in response to glucose limitation [Term] id: GO:2000220 name: regulation of pseudohyphal growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pseudohyphal growth." [GOC:mah] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells relationship: regulates GO:0007124 ! pseudohyphal growth [Term] id: GO:2000221 name: negative regulation of pseudohyphal growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth." [GOC:mah] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells is_a: GO:2000220 ! regulation of pseudohyphal growth relationship: negatively_regulates GO:0007124 ! pseudohyphal growth [Term] id: GO:2000222 name: positive regulation of pseudohyphal growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth." [GOC:mah] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells is_a: GO:2000220 ! regulation of pseudohyphal growth relationship: positively_regulates GO:0007124 ! pseudohyphal growth [Term] id: GO:2000223 name: regulation of BMP signaling pathway involved in heart jogging namespace: biological_process def: "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging." [GOC:BHF] synonym: "regulation of BMP signalling pathway involved in heart jogging pathway involved in somitogenesis" EXACT [GOC:mah] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0045995 ! regulation of embryonic development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0003303 ! BMP signaling pathway involved in heart jogging [Term] id: GO:2000224 name: regulation of testosterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process relationship: regulates GO:0061370 ! testosterone biosynthetic process [Term] id: GO:2000225 name: negative regulation of testosterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol] is_a: GO:2000180 ! negative regulation of androgen biosynthetic process is_a: GO:2000224 ! regulation of testosterone biosynthetic process relationship: negatively_regulates GO:0061370 ! testosterone biosynthetic process [Term] id: GO:2000226 name: regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0003310 ! pancreatic A cell differentiation [Term] id: GO:2000227 name: negative regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "negative regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000226 ! regulation of pancreatic A cell differentiation relationship: negatively_regulates GO:0003310 ! pancreatic A cell differentiation [Term] id: GO:2000228 name: positive regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "positive regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000226 ! regulation of pancreatic A cell differentiation relationship: positively_regulates GO:0003310 ! pancreatic A cell differentiation [Term] id: GO:2000229 name: regulation of pancreatic stellate cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0072343 ! pancreatic stellate cell proliferation [Term] id: GO:2000230 name: negative regulation of pancreatic stellate cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation relationship: negatively_regulates GO:0072343 ! pancreatic stellate cell proliferation [Term] id: GO:2000231 name: positive regulation of pancreatic stellate cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation relationship: positively_regulates GO:0072343 ! pancreatic stellate cell proliferation [Term] id: GO:2000232 name: regulation of rRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rRNA processing." [GOC:mah] synonym: "regulation of 35S primary transcript processing" RELATED [GOC:obol] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051252 ! regulation of RNA metabolic process is_a: GO:0090069 ! regulation of ribosome biogenesis relationship: regulates GO:0006364 ! rRNA processing [Term] id: GO:2000233 name: negative regulation of rRNA processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing." [GOC:mah] synonym: "negative regulation of 35S primary transcript processing" RELATED [GOC:obol] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000232 ! regulation of rRNA processing relationship: negatively_regulates GO:0006364 ! rRNA processing [Term] id: GO:2000234 name: positive regulation of rRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah] synonym: "positive regulation of 35S primary transcript processing" RELATED [GOC:obol] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2000232 ! regulation of rRNA processing relationship: positively_regulates GO:0006364 ! rRNA processing [Term] id: GO:2000235 name: regulation of tRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tRNA processing." [GOC:mah] synonym: "regulation of tRNA maturation" EXACT [GOC:obol] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0008033 ! tRNA processing [Term] id: GO:2000236 name: negative regulation of tRNA processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA processing." [GOC:mah] synonym: "negative regulation of tRNA maturation" EXACT [GOC:obol] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000235 ! regulation of tRNA processing relationship: negatively_regulates GO:0008033 ! tRNA processing [Term] id: GO:2000237 name: positive regulation of tRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA processing." [GOC:mah] synonym: "positive regulation of tRNA maturation" EXACT [GOC:obol] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2000235 ! regulation of tRNA processing relationship: positively_regulates GO:0008033 ! tRNA processing [Term] id: GO:2000238 name: regulation of tRNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] synonym: "regulation of tRNA export from cell nucleus" EXACT [GOC:obol] synonym: "regulation of tRNA export out of nucleus" EXACT [GOC:obol] synonym: "regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "regulation of tRNA-nucleus export" EXACT [GOC:obol] is_a: GO:0046831 ! regulation of RNA export from nucleus relationship: regulates GO:0006409 ! tRNA export from nucleus [Term] id: GO:2000239 name: negative regulation of tRNA export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] synonym: "negative regulation of tRNA export from cell nucleus" EXACT [GOC:obol] synonym: "negative regulation of tRNA export out of nucleus" EXACT [GOC:obol] synonym: "negative regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "negative regulation of tRNA-nucleus export" EXACT [GOC:obol] is_a: GO:0046832 ! negative regulation of RNA export from nucleus is_a: GO:2000238 ! regulation of tRNA export from nucleus relationship: negatively_regulates GO:0006409 ! tRNA export from nucleus [Term] id: GO:2000240 name: positive regulation of tRNA export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] synonym: "positive regulation of tRNA export from cell nucleus" EXACT [GOC:obol] synonym: "positive regulation of tRNA export out of nucleus" EXACT [GOC:obol] synonym: "positive regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "positive regulation of tRNA-nucleus export" EXACT [GOC:obol] is_a: GO:0046833 ! positive regulation of RNA export from nucleus is_a: GO:2000238 ! regulation of tRNA export from nucleus relationship: positively_regulates GO:0006409 ! tRNA export from nucleus [Term] id: GO:2000241 name: regulation of reproductive process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0022414 ! reproductive process [Term] id: GO:2000242 name: negative regulation of reproductive process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process relationship: negatively_regulates GO:0022414 ! reproductive process [Term] id: GO:2000243 name: positive regulation of reproductive process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process relationship: positively_regulates GO:0022414 ! reproductive process [Term] id: GO:2000244 name: regulation of cytokinesis by binary fission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytokinesis by binary fission." [GOC:mah] synonym: "regulation of prokaryote-type cytokinesis" EXACT [GOC:obol] synonym: "regulation of prokaryotic fission" EXACT [GOC:obol] is_a: GO:0032465 ! regulation of cytokinesis relationship: regulates GO:0043093 ! cytokinesis by binary fission [Term] id: GO:2000245 name: negative regulation of cytokinesis by binary fission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytokinesis by binary fission." [GOC:mah] synonym: "negative regulation of prokaryote-type cytokinesis" EXACT [GOC:obol] synonym: "negative regulation of prokaryotic fission" EXACT [GOC:obol] is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:2000244 ! regulation of cytokinesis by binary fission relationship: negatively_regulates GO:0043093 ! cytokinesis by binary fission [Term] id: GO:2000246 name: positive regulation of cytokinesis by binary fission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytokinesis by binary fission." [GOC:mah] synonym: "positive regulation of prokaryote-type cytokinesis" EXACT [GOC:obol] synonym: "positive regulation of prokaryotic fission" EXACT [GOC:obol] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:2000244 ! regulation of cytokinesis by binary fission relationship: positively_regulates GO:0043093 ! cytokinesis by binary fission [Term] id: GO:2000247 name: positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape relationship: positively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape [Term] id: GO:2000248 name: negative regulation of establishment or maintenance of neuroblast polarity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol] synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity [Term] id: GO:2000249 name: regulation of actin cytoskeleton reorganization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF] synonym: "regulation of actin cytoskeleton remodeling" EXACT [GOC:obol] synonym: "regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol] is_a: GO:0032956 ! regulation of actin cytoskeleton organization relationship: regulates GO:0031532 ! actin cytoskeleton reorganization [Term] id: GO:2000250 name: negative regulation of actin cytoskeleton reorganization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF] synonym: "negative regulation of actin cytoskeleton remodeling" EXACT [GOC:obol] synonym: "negative regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:2000249 ! regulation of actin cytoskeleton reorganization relationship: negatively_regulates GO:0031532 ! actin cytoskeleton reorganization [Term] id: GO:2000251 name: positive regulation of actin cytoskeleton reorganization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF] synonym: "positive regulation of actin cytoskeleton remodeling" EXACT [GOC:obol] synonym: "positive regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:2000249 ! regulation of actin cytoskeleton reorganization relationship: positively_regulates GO:0031532 ! actin cytoskeleton reorganization [Term] id: GO:2000252 name: negative regulation of feeding behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol] synonym: "negative regulation of behavioral response to food" EXACT [GOC:obol] synonym: "negative regulation of behavioural response to food" EXACT [GOC:obol] synonym: "negative regulation of drinking" RELATED [GOC:obol] synonym: "negative regulation of eating" RELATED [GOC:obol] synonym: "negative regulation of feeding behaviour" EXACT [GOC:obol] is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0060259 ! regulation of feeding behavior relationship: negatively_regulates GO:0007631 ! feeding behavior [Term] id: GO:2000253 name: positive regulation of feeding behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol] synonym: "positive regulation of behavioral response to food" EXACT [GOC:obol] synonym: "positive regulation of behavioural response to food" EXACT [GOC:obol] synonym: "positive regulation of drinking" RELATED [GOC:obol] synonym: "positive regulation of eating" RELATED [GOC:obol] synonym: "positive regulation of feeding behaviour" EXACT [GOC:obol] is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0060259 ! regulation of feeding behavior relationship: positively_regulates GO:0007631 ! feeding behavior [Term] id: GO:2000254 name: regulation of male germ cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of male germ cell proliferation." [GOC:obol] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0002176 ! male germ cell proliferation [Term] id: GO:2000255 name: negative regulation of male germ cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:2000242 ! negative regulation of reproductive process is_a: GO:2000254 ! regulation of male germ cell proliferation relationship: negatively_regulates GO:0002176 ! male germ cell proliferation [Term] id: GO:2000256 name: positive regulation of male germ cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of male germ cell proliferation." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:2000243 ! positive regulation of reproductive process is_a: GO:2000254 ! regulation of male germ cell proliferation relationship: positively_regulates GO:0002176 ! male germ cell proliferation [Term] id: GO:2000257 name: regulation of protein activation cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein activation cascade." [GOC:mah] synonym: "regulation of protein activation pathway" EXACT [GOC:obol] synonym: "regulation of protein activitory cascade" EXACT [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0051246 ! regulation of protein metabolic process relationship: regulates GO:0072376 ! protein activation cascade [Term] id: GO:2000258 name: negative regulation of protein activation cascade namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade." [GOC:mah] synonym: "negative regulation of protein activation pathway" EXACT [GOC:obol] synonym: "negative regulation of protein activitory cascade" EXACT [GOC:obol] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:2000257 ! regulation of protein activation cascade relationship: negatively_regulates GO:0072376 ! protein activation cascade [Term] id: GO:2000259 name: positive regulation of protein activation cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein activation cascade." [GOC:mah] synonym: "positive regulation of protein activation pathway" EXACT [GOC:obol] synonym: "positive regulation of protein activitory cascade" EXACT [GOC:obol] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:2000257 ! regulation of protein activation cascade relationship: positively_regulates GO:0072376 ! protein activation cascade [Term] id: GO:2000260 name: regulation of blood coagulation, common pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:2000257 ! regulation of protein activation cascade relationship: regulates GO:0072377 ! blood coagulation, common pathway [Term] id: GO:2000261 name: negative regulation of blood coagulation, common pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah] is_a: GO:2000258 ! negative regulation of protein activation cascade is_a: GO:2000260 ! regulation of blood coagulation, common pathway relationship: negatively_regulates GO:0072377 ! blood coagulation, common pathway [Term] id: GO:2000262 name: positive regulation of blood coagulation, common pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah] is_a: GO:2000259 ! positive regulation of protein activation cascade is_a: GO:2000260 ! regulation of blood coagulation, common pathway relationship: positively_regulates GO:0072377 ! blood coagulation, common pathway [Term] id: GO:2000263 name: regulation of blood coagulation, extrinsic pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:2000257 ! regulation of protein activation cascade relationship: regulates GO:0007598 ! blood coagulation, extrinsic pathway [Term] id: GO:2000264 name: negative regulation of blood coagulation, extrinsic pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah] is_a: GO:2000258 ! negative regulation of protein activation cascade is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway relationship: negatively_regulates GO:0007598 ! blood coagulation, extrinsic pathway [Term] id: GO:2000265 name: positive regulation of blood coagulation, extrinsic pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah] is_a: GO:2000259 ! positive regulation of protein activation cascade is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway relationship: positively_regulates GO:0007598 ! blood coagulation, extrinsic pathway [Term] id: GO:2000266 name: regulation of blood coagulation, intrinsic pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:2000257 ! regulation of protein activation cascade relationship: regulates GO:0007597 ! blood coagulation, intrinsic pathway [Term] id: GO:2000267 name: negative regulation of blood coagulation, intrinsic pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah] is_a: GO:2000258 ! negative regulation of protein activation cascade is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway relationship: negatively_regulates GO:0007597 ! blood coagulation, intrinsic pathway [Term] id: GO:2000268 name: positive regulation of blood coagulation, intrinsic pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah] is_a: GO:2000259 ! positive regulation of protein activation cascade is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway relationship: positively_regulates GO:0007597 ! blood coagulation, intrinsic pathway [Term] id: GO:2000269 name: regulation of fibroblast apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast apoptosis." [GOC:obol] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0044346 ! fibroblast apoptosis [Term] id: GO:2000270 name: negative regulation of fibroblast apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptosis." [GOC:obol] is_a: GO:0043066 ! negative regulation of apoptosis is_a: GO:2000269 ! regulation of fibroblast apoptosis relationship: negatively_regulates GO:0044346 ! fibroblast apoptosis [Term] id: GO:2000271 name: positive regulation of fibroblast apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptosis." [GOC:obol] is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:2000269 ! regulation of fibroblast apoptosis relationship: positively_regulates GO:0044346 ! fibroblast apoptosis [Term] id: GO:2000272 name: negative regulation of receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity." [GOC:obol] is_a: GO:0010469 ! regulation of receptor activity is_a: GO:0044092 ! negative regulation of molecular function [Term] id: GO:2000273 name: positive regulation of receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor activity." [GOC:obol] is_a: GO:0010469 ! regulation of receptor activity is_a: GO:0044093 ! positive regulation of molecular function [Term] id: GO:2000274 name: regulation of epithelial cell migration, open tracheal system namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol] synonym: "regulation of tracheal cell migration" RELATED [GOC:obol] synonym: "regulation of tracheal epithelial cell migration" RELATED [GOC:obol] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0007427 ! epithelial cell migration, open tracheal system [Term] id: GO:2000275 name: regulation of oxidative phosphorylation uncoupler activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah] synonym: "regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol] synonym: "regulation of uncoupling protein activity" RELATED [GOC:obol] is_a: GO:0010155 ! regulation of proton transport is_a: GO:0022898 ! regulation of transmembrane transporter activity [Term] id: GO:2000276 name: negative regulation of oxidative phosphorylation uncoupler activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah] synonym: "negative regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol] synonym: "negative regulation of uncoupling protein activity" RELATED [GOC:obol] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity [Term] id: GO:2000277 name: positive regulation of oxidative phosphorylation uncoupler activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah] synonym: "positive regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol] synonym: "positive regulation of uncoupling protein activity" RELATED [GOC:obol] is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity [Term] id: GO:2000278 name: regulation of DNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "regulation of DNA anabolism" EXACT [GOC:obol] synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of DNA formation" EXACT [GOC:obol] synonym: "regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0071897 ! DNA biosynthetic process [Term] id: GO:2000279 name: negative regulation of DNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol] synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of DNA formation" EXACT [GOC:obol] synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process is_a: GO:2000278 ! regulation of DNA biosynthetic process relationship: negatively_regulates GO:0071897 ! DNA biosynthetic process [Term] id: GO:2000280 name: regulation of root development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of root development." [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0048364 ! root development [Term] id: GO:2000281 name: regulation of histone H3-T3 phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-T3 phosphorylation." [GOC:obol] is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation is_a: GO:0033127 ! regulation of histone phosphorylation relationship: regulates GO:0072355 ! histone H3-T3 phosphorylation [Term] id: GO:2000282 name: regulation of cellular amino acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "regulation of amino acid biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0008652 ! cellular amino acid biosynthetic process [Term] id: GO:2000283 name: negative regulation of cellular amino acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "negative regulation of amino acid biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process relationship: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process [Term] id: GO:2000284 name: positive regulation of cellular amino acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "positive regulation of amino acid biosynthetic process" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process relationship: positively_regulates GO:0008652 ! cellular amino acid biosynthetic process [Term] id: GO:2000285 name: negative regulation of regulation of excitatory postsynaptic membrane potential namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of excitatory postsynaptic membrane potential." [GOC:BHF] comment: This term was made obsolete because it makes no sense and was added in error. synonym: "negative regulation of EPSP" RELATED [GOC:obol] is_obsolete: true replaced_by: GO:0090394 [Term] id: GO:2000286 name: receptor internalization involved in canonical Wnt receptor signaling pathway namespace: biological_process def: "A receptor internalization process that contributes to canonical Wnt receptor signaling pathway." [GOC:BHF, GOC:mah, PMID:16890161] synonym: "receptor internalization involved in canonical Wnt receptor signalling pathway" EXACT [GOC:obol] synonym: "receptor internalization involved in canonical Wnt signaling pathway" EXACT [GOC:obol] synonym: "receptor internalization involved in frizzled-1 receptor signaling pathway" RELATED [GOC:obol] synonym: "receptor internalization involved in Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:obol] synonym: "receptor internalization involved in Wnt receptor signaling pathway via beta-catenin" EXACT [GOC:obol] synonym: "receptor internalization involved in Wnt receptor signalling pathway through beta-catenin" EXACT [GOC:obol] is_a: GO:0031623 ! receptor internalization relationship: part_of GO:0060070 ! canonical Wnt receptor signaling pathway [Term] id: GO:2000287 name: positive regulation of myotome development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000290 ! regulation of myotome development relationship: positively_regulates GO:0061055 ! myotome development [Term] id: GO:2000288 name: positive regulation of myoblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:2000291 ! regulation of myoblast proliferation relationship: positively_regulates GO:0051450 ! myoblast proliferation [Term] id: GO:2000289 name: regulation of photoreceptor cell axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah] synonym: "regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol] is_a: GO:0050770 ! regulation of axonogenesis is_a: GO:0050920 ! regulation of chemotaxis relationship: regulates GO:0072499 ! photoreceptor cell axon guidance [Term] id: GO:2000290 name: regulation of myotome development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah] is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0061055 ! myotome development [Term] id: GO:2000291 name: regulation of myoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell proliferation relationship: regulates GO:0051450 ! myoblast proliferation [Term] id: GO:2000292 name: regulation of defecation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0044062 ! regulation of excretion relationship: regulates GO:0030421 ! defecation [Term] id: GO:2000293 name: negative regulation of defecation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000292 ! regulation of defecation relationship: negatively_regulates GO:0030421 ! defecation [Term] id: GO:2000294 name: positive regulation of defecation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000292 ! regulation of defecation relationship: positively_regulates GO:0030421 ! defecation [Term] id: GO:2000295 name: regulation of hydrogen peroxide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF] synonym: "regulation of detoxification of H2O2" RELATED [GOC:obol] synonym: "regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol] synonym: "regulation of H2O2 catabolic process" EXACT [GOC:obol] synonym: "regulation of H2O2 scavenging" RELATED [GOC:obol] synonym: "regulation of hydrogen peroxide breakdown" EXACT [GOC:obol] synonym: "regulation of hydrogen peroxide catabolism" EXACT [GOC:obol] synonym: "regulation of hydrogen peroxide degradation" EXACT [GOC:obol] synonym: "regulation of hydrogen peroxide removal" RELATED [GOC:obol] synonym: "regulation of hydrogen peroxide scavenging" RELATED [GOC:obol] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0042744 ! hydrogen peroxide catabolic process [Term] id: GO:2000296 name: negative regulation of hydrogen peroxide catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF] synonym: "negative regulation of detoxification of H2O2" RELATED [GOC:obol] synonym: "negative regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol] synonym: "negative regulation of H2O2 catabolic process" EXACT [GOC:obol] synonym: "negative regulation of H2O2 scavenging" RELATED [GOC:obol] synonym: "negative regulation of hydrogen peroxide breakdown" EXACT [GOC:obol] synonym: "negative regulation of hydrogen peroxide catabolism" EXACT [GOC:obol] synonym: "negative regulation of hydrogen peroxide degradation" EXACT [GOC:obol] synonym: "negative regulation of hydrogen peroxide removal" RELATED [GOC:obol] synonym: "negative regulation of hydrogen peroxide scavenging" RELATED [GOC:obol] is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000295 ! regulation of hydrogen peroxide catabolic process relationship: negatively_regulates GO:0042744 ! hydrogen peroxide catabolic process [Term] id: GO:2000297 name: negative regulation of synapse maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation." [GOC:mah] synonym: "negative regulation of synaptic maturation" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0090128 ! regulation of synapse maturation relationship: negatively_regulates GO:0060074 ! synapse maturation [Term] id: GO:2000298 name: regulation of Rho-dependent protein serine/threonine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah] synonym: "regulation of Rho-associated protein kinase activity" EXACT [GOC:obol] synonym: "regulation of ROCK kinase activity" EXACT [GOC:obol] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity [Term] id: GO:2000299 name: negative regulation of Rho-dependent protein serine/threonine kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah] synonym: "negative regulation of Rho-associated protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of ROCK kinase activity" EXACT [GOC:obol] is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity is_a: GO:2000298 ! regulation of Rho-dependent protein serine/threonine kinase activity [Term] id: GO:2000300 name: regulation of synaptic vesicle exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0046928 ! regulation of neurotransmitter secretion relationship: regulates GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:2000301 name: negative regulation of synaptic vesicle exocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis relationship: negatively_regulates GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:2000302 name: positive regulation of synaptic vesicle exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis relationship: positively_regulates GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:2000303 name: regulation of ceramide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ceramide biosynthetic process." [GOC:dph] synonym: "regulation of ceramide anabolism" EXACT [GOC:obol] synonym: "regulation of ceramide biosynthesis" EXACT [GOC:obol] synonym: "regulation of ceramide formation" EXACT [GOC:obol] synonym: "regulation of ceramide synthesis" EXACT [GOC:obol] is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process relationship: regulates GO:0046513 ! ceramide biosynthetic process [Term] id: GO:2000304 name: positive regulation of ceramide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process." [GOC:dph] synonym: "positive regulation of ceramide anabolism" EXACT [GOC:obol] synonym: "positive regulation of ceramide biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of ceramide formation" EXACT [GOC:obol] synonym: "positive regulation of ceramide synthesis" EXACT [GOC:obol] is_a: GO:0090154 ! positive regulation of sphingolipid biosynthetic process is_a: GO:2000303 ! regulation of ceramide biosynthetic process relationship: positively_regulates GO:0046513 ! ceramide biosynthetic process [Term] id: GO:2000305 name: semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance namespace: biological_process def: "Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance." [GOC:obol] synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol] synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol] synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol] synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol] is_a: GO:0071526 ! semaphorin-plexin signaling pathway relationship: part_of GO:2000289 ! regulation of photoreceptor cell axon guidance [Term] id: GO:2000306 name: positive regulation of photomorphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of photomorphogenesis." [GOC:obol] synonym: "positive regulation of plant development in response to light" EXACT [GOC:obol] is_a: GO:0010099 ! regulation of photomorphogenesis is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0009640 ! photomorphogenesis [Term] id: GO:2000307 name: regulation of tumor necrosis factor (ligand) superfamily member 11 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] synonym: "regulation of RANKL production" EXACT [GOC:obol] synonym: "regulation of TNFSF11 production" EXACT [GOC:obol] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production [Term] id: GO:2000308 name: negative regulation of tumor necrosis factor (ligand) superfamily member 11 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] synonym: "negative regulation of RANKL production" EXACT [GOC:obol] synonym: "negative regulation of TNFSF11 production" EXACT [GOC:obol] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production relationship: negatively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production [Term] id: GO:2000309 name: positive regulation of tumor necrosis factor (ligand) superfamily member 11 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] synonym: "positive regulation of RANKL production" EXACT [GOC:obol] synonym: "positive regulation of TNFSF11 production" EXACT [GOC:obol] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production relationship: positively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production [Term] id: GO:2000310 name: regulation of N-methyl-D-aspartate selective glutamate receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity." [GOC:BHF] synonym: "regulation of NMDA receptor" EXACT [GOC:obol] is_a: GO:0010469 ! regulation of receptor activity [Term] id: GO:2000311 name: regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity." [GOC:BHF] synonym: "regulation of AMPA receptor activity" EXACT [GOC:obol] is_a: GO:0010469 ! regulation of receptor activity [Term] id: GO:2000312 name: regulation of kainate selective glutamate receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity." [GOC:BHF] is_a: GO:0010469 ! regulation of receptor activity [Term] id: GO:2000313 name: regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF] synonym: "regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol] is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [Term] id: GO:2000314 name: negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF] synonym: "negative regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol] is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation relationship: negatively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [Term] id: GO:2000315 name: positive regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF] synonym: "positive regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol] is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation relationship: positively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [Term] id: GO:2000316 name: regulation of T-helper 17 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] synonym: "regulation of Th17 immune response" EXACT [GOC:obol] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0072538 ! T-helper 17 type immune response [Term] id: GO:2000317 name: negative regulation of T-helper 17 type immune response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] synonym: "negative regulation of Th17 immune response" EXACT [GOC:obol] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:2000316 ! regulation of T-helper 17 type immune response relationship: negatively_regulates GO:0072538 ! T-helper 17 type immune response [Term] id: GO:2000318 name: positive regulation of T-helper 17 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] synonym: "positive regulation of Th17 immune response" EXACT [GOC:obol] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:2000316 ! regulation of T-helper 17 type immune response relationship: positively_regulates GO:0072538 ! T-helper 17 type immune response [Term] id: GO:2000319 name: regulation of T-helper 17 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] synonym: "regulation of T-helper 17 cell development" RELATED [GOC:obol] is_a: GO:0045622 ! regulation of T-helper cell differentiation is_a: GO:2000316 ! regulation of T-helper 17 type immune response relationship: regulates GO:0072539 ! T-helper 17 cell differentiation [Term] id: GO:2000320 name: negative regulation of T-helper 17 cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] synonym: "negative regulation of T-helper 17 cell development" RELATED [GOC:obol] is_a: GO:0045623 ! negative regulation of T-helper cell differentiation is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation relationship: negatively_regulates GO:0072539 ! T-helper 17 cell differentiation [Term] id: GO:2000321 name: positive regulation of T-helper 17 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] synonym: "positive regulation of T-helper 17 cell development" RELATED [GOC:obol] is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation relationship: positively_regulates GO:0072539 ! T-helper 17 cell differentiation [Term] id: GO:2000322 name: regulation of glucocorticoid receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF] synonym: "regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol] is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway relationship: regulates GO:0042921 ! glucocorticoid receptor signaling pathway [Term] id: GO:2000323 name: negative regulation of glucocorticoid receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF] synonym: "negative regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol] is_a: GO:0033144 ! negative regulation of steroid hormone receptor signaling pathway is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway relationship: negatively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway [Term] id: GO:2000324 name: positive regulation of glucocorticoid receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF] synonym: "positive regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol] is_a: GO:0033145 ! positive regulation of steroid hormone receptor signaling pathway is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway relationship: positively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway [Term] id: GO:2000325 name: regulation of ligand-dependent nuclear receptor transcription coactivator activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF] synonym: "regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:2000326 name: negative regulation of ligand-dependent nuclear receptor transcription coactivator activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF] synonym: "negative regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:2000325 ! regulation of ligand-dependent nuclear receptor transcription coactivator activity [Term] id: GO:2000327 name: positive regulation of ligand-dependent nuclear receptor transcription coactivator activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF] synonym: "positive regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:2000325 ! regulation of ligand-dependent nuclear receptor transcription coactivator activity [Term] id: GO:2000328 name: regulation of T-helper 17 cell lineage commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah] synonym: "regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol] synonym: "regulation of Th17 cell lineage commitment" EXACT [GOC:obol] synonym: "regulation of Th17 fate commitment" EXACT [GOC:obol] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation relationship: regulates GO:0072540 ! T-helper 17 cell lineage commitment [Term] id: GO:2000329 name: negative regulation of T-helper 17 cell lineage commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah] synonym: "negative regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol] synonym: "negative regulation of Th17 cell lineage commitment" EXACT [GOC:obol] synonym: "negative regulation of Th17 fate commitment" EXACT [GOC:obol] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment relationship: negatively_regulates GO:0072540 ! T-helper 17 cell lineage commitment [Term] id: GO:2000330 name: positive regulation of T-helper 17 cell lineage commitment namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah] synonym: "positive regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol] synonym: "positive regulation of Th17 cell lineage commitment" EXACT [GOC:obol] synonym: "positive regulation of Th17 fate commitment" EXACT [GOC:obol] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment relationship: positively_regulates GO:0072540 ! T-helper 17 cell lineage commitment [Term] id: GO:2000331 name: regulation of terminal button organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] synonym: "regulation of bouton organization" EXACT [GOC:obol] synonym: "regulation of presynaptic bouton organization" EXACT [GOC:obol] synonym: "regulation of synaptic bouton organization" EXACT [GOC:obol] synonym: "regulation of terminal bouton organization" EXACT [GOC:obol] synonym: "regulation of terminal button organisation" EXACT [GOC:obol] is_a: GO:0050807 ! regulation of synapse organization relationship: regulates GO:0072553 ! terminal button organization [Term] id: GO:2000332 name: regulation of blood microparticle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah] synonym: "regulation of microparticle generation" EXACT [GOC:obol] synonym: "regulation of microparticle release" EXACT [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0072564 ! blood microparticle formation [Term] id: GO:2000333 name: negative regulation of blood microparticle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah] synonym: "negative regulation of microparticle generation" EXACT [GOC:obol] synonym: "negative regulation of microparticle release" EXACT [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:2000332 ! regulation of blood microparticle formation relationship: negatively_regulates GO:0072564 ! blood microparticle formation [Term] id: GO:2000334 name: positive regulation of blood microparticle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah] synonym: "positive regulation of microparticle generation" EXACT [GOC:obol] synonym: "positive regulation of microparticle release" EXACT [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:2000332 ! regulation of blood microparticle formation relationship: positively_regulates GO:0072564 ! blood microparticle formation [Term] id: GO:2000335 name: regulation of endothelial microparticle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah] synonym: "regulation of endothelial microparticle generation" EXACT [GOC:obol] synonym: "regulation of endothelial microparticle release" EXACT [GOC:obol] is_a: GO:2000332 ! regulation of blood microparticle formation relationship: regulates GO:0072565 ! endothelial microparticle formation [Term] id: GO:2000336 name: negative regulation of endothelial microparticle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah] synonym: "negative regulation of endothelial microparticle generation" EXACT [GOC:obol] synonym: "negative regulation of endothelial microparticle release" EXACT [GOC:obol] is_a: GO:2000333 ! negative regulation of blood microparticle formation is_a: GO:2000335 ! regulation of endothelial microparticle formation relationship: negatively_regulates GO:0072565 ! endothelial microparticle formation [Term] id: GO:2000337 name: positive regulation of endothelial microparticle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah] synonym: "positive regulation of endothelial microparticle generation" EXACT [GOC:obol] synonym: "positive regulation of endothelial microparticle release" EXACT [GOC:obol] is_a: GO:2000334 ! positive regulation of blood microparticle formation is_a: GO:2000335 ! regulation of endothelial microparticle formation relationship: positively_regulates GO:0072565 ! endothelial microparticle formation [Term] id: GO:2000338 name: regulation of chemokine (C-X-C motif) ligand 1 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah] synonym: "regulation of CXCL1 production" EXACT [GOC:obol] synonym: "regulation of KC production" EXACT [GOC:obol] synonym: "regulation of keratinocyte derived chemokine production" EXACT [GOC:obol] synonym: "regulation of SCYB1 production" EXACT [GOC:obol] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production [Term] id: GO:2000339 name: negative regulation of chemokine (C-X-C motif) ligand 1 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah] synonym: "negative regulation of CXCL1 production" EXACT [GOC:obol] synonym: "negative regulation of KC production" EXACT [GOC:obol] synonym: "negative regulation of keratinocyte derived chemokine production" EXACT [GOC:obol] synonym: "negative regulation of SCYB1 production" EXACT [GOC:obol] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production relationship: negatively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production [Term] id: GO:2000340 name: positive regulation of chemokine (C-X-C motif) ligand 1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah] synonym: "positive regulation of CXCL1 production" EXACT [GOC:obol] synonym: "positive regulation of KC production" EXACT [GOC:obol] synonym: "positive regulation of keratinocyte derived chemokine production" EXACT [GOC:obol] synonym: "positive regulation of SCYB1 production" EXACT [GOC:obol] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production relationship: positively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production [Term] id: GO:2000341 name: regulation of chemokine (C-X-C motif) ligand 2 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] synonym: "regulation of CXCL2 production" EXACT [GOC:obol] synonym: "regulation of MIP-2 production" EXACT [GOC:obol] synonym: "regulation of MIP2 production" EXACT [GOC:obol] synonym: "regulation of SCYB2 production" EXACT [GOC:obol] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production [Term] id: GO:2000342 name: negative regulation of chemokine (C-X-C motif) ligand 2 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] synonym: "negative regulation of CXCL2 production" EXACT [GOC:obol] synonym: "negative regulation of MIP-2 production" EXACT [GOC:obol] synonym: "negative regulation of MIP2 production" EXACT [GOC:obol] synonym: "negative regulation of SCYB2 production" EXACT [GOC:obol] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production relationship: negatively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production [Term] id: GO:2000343 name: positive regulation of chemokine (C-X-C motif) ligand 2 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] synonym: "positive regulation of CXCL2 production" EXACT [GOC:obol] synonym: "positive regulation of MIP-2 production" EXACT [GOC:obol] synonym: "positive regulation of MIP2 production" EXACT [GOC:obol] synonym: "positive regulation of SCYB2 production" EXACT [GOC:obol] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production relationship: positively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production [Term] id: GO:2000344 name: positive regulation of acrosome reaction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the acrosome reaction." [GOC:obol] is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis is_a: GO:0060046 ! regulation of acrosome reaction is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0007340 ! acrosome reaction [Term] id: GO:2000345 name: regulation of hepatocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah] is_a: GO:0050678 ! regulation of epithelial cell proliferation is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0072574 ! hepatocyte proliferation [Term] id: GO:2000346 name: negative regulation of hepatocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:2000345 ! regulation of hepatocyte proliferation relationship: negatively_regulates GO:0072574 ! hepatocyte proliferation [Term] id: GO:2000347 name: positive regulation of hepatocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:2000345 ! regulation of hepatocyte proliferation relationship: positively_regulates GO:0072574 ! hepatocyte proliferation [Term] id: GO:2000348 name: regulation of CD40 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:mah] synonym: "regulation of CD40 signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0023035 ! CD40 signaling pathway [Term] id: GO:2000349 name: negative regulation of CD40 signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah] synonym: "negative regulation of CD40 signalling pathway" EXACT [GOC:obol] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:2000348 ! regulation of CD40 signaling pathway relationship: negatively_regulates GO:0023035 ! CD40 signaling pathway [Term] id: GO:2000350 name: positive regulation of CD40 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah] synonym: "positive regulation of CD40 signalling pathway" EXACT [GOC:obol] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:2000348 ! regulation of CD40 signaling pathway relationship: positively_regulates GO:0023035 ! CD40 signaling pathway [Term] id: GO:2000351 name: regulation of endothelial cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptosis." [GOC:mah] synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0072577 ! endothelial cell apoptosis [Term] id: GO:2000352 name: negative regulation of endothelial cell apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptosis." [GOC:BHF, GOC:mah] synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0043066 ! negative regulation of apoptosis is_a: GO:2000351 ! regulation of endothelial cell apoptosis relationship: negatively_regulates GO:0072577 ! endothelial cell apoptosis [Term] id: GO:2000353 name: positive regulation of endothelial cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptosis." [GOC:BHF, GOC:mah] synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:2000351 ! regulation of endothelial cell apoptosis relationship: positively_regulates GO:0072577 ! endothelial cell apoptosis [Term] id: GO:2000354 name: regulation of ovarian follicle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ovarian follicle development." [GOC:obol] synonym: "regulation of follicular phase" RELATED [GOC:obol] is_a: GO:2000194 ! regulation of female gonad development relationship: regulates GO:0001541 ! ovarian follicle development [Term] id: GO:2000355 name: negative regulation of ovarian follicle development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian follicle development." [GOC:obol] synonym: "negative regulation of follicular phase" RELATED [GOC:obol] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000354 ! regulation of ovarian follicle development relationship: negatively_regulates GO:0001541 ! ovarian follicle development [Term] id: GO:2000356 name: regulation of kidney smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol] is_a: GO:0051150 ! regulation of smooth muscle cell differentiation is_a: GO:0090183 ! regulation of kidney development relationship: regulates GO:0072195 ! kidney smooth muscle cell differentiation [Term] id: GO:2000357 name: negative regulation of kidney smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation relationship: negatively_regulates GO:0072195 ! kidney smooth muscle cell differentiation [Term] id: GO:2000358 name: positive regulation of kidney smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation relationship: positively_regulates GO:0072195 ! kidney smooth muscle cell differentiation [Term] id: GO:2000359 name: regulation of binding of sperm to zona pellucida namespace: biological_process def: "Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol] synonym: "regulation of ZPG binding" RELATED [GOC:obol] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0007339 ! binding of sperm to zona pellucida [Term] id: GO:2000360 name: negative regulation of binding of sperm to zona pellucida namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol] synonym: "negative regulation of ZPG binding" RELATED [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000242 ! negative regulation of reproductive process is_a: GO:2000359 ! regulation of binding of sperm to zona pellucida relationship: negatively_regulates GO:0007339 ! binding of sperm to zona pellucida [Term] id: GO:2000361 name: regulation of prostaglandin-E synthase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF] synonym: "regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol] synonym: "regulation of endoperoxide isomerase activity" EXACT [GOC:obol] synonym: "regulation of PGE isomerase activity" EXACT [GOC:obol] synonym: "regulation of PGE2 isomerase activity" EXACT [GOC:obol] synonym: "regulation of PGH-PGE isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol] synonym: "regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol] is_a: GO:0010911 ! regulation of isomerase activity [Term] id: GO:2000362 name: negative regulation of prostaglandin-E synthase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF] synonym: "negative regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of endoperoxide isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of PGE isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of PGE2 isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of PGH-PGE isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:2000361 ! regulation of prostaglandin-E synthase activity [Term] id: GO:2000363 name: positive regulation of prostaglandin-E synthase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF] synonym: "positive regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of endoperoxide isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of PGE isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of PGE2 isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of PGH-PGE isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol] is_a: GO:0010912 ! positive regulation of isomerase activity is_a: GO:2000361 ! regulation of prostaglandin-E synthase activity [Term] id: GO:2000364 name: regulation of STAT protein import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of STAT protein import into nucleus." [GOC:BHF] synonym: "regulation of STAT protein nuclear translocation" RELATED [GOC:obol] is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0046425 ! regulation of JAK-STAT cascade relationship: regulates GO:0007262 ! STAT protein import into nucleus [Term] id: GO:2000365 name: negative regulation of STAT protein import into nucleus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of STAT protein import into nucleus." [GOC:BHF] synonym: "negative regulation of STAT protein nuclear translocation" RELATED [GOC:obol] is_a: GO:0042308 ! negative regulation of protein import into nucleus is_a: GO:0046426 ! negative regulation of JAK-STAT cascade is_a: GO:2000364 ! regulation of STAT protein import into nucleus relationship: negatively_regulates GO:0007262 ! STAT protein import into nucleus [Term] id: GO:2000366 name: positive regulation of STAT protein import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of STAT protein import into nucleus." [GOC:BHF] synonym: "positive regulation of STAT protein nuclear translocation" RELATED [GOC:obol] is_a: GO:0042307 ! positive regulation of protein import into nucleus is_a: GO:0046427 ! positive regulation of JAK-STAT cascade is_a: GO:2000364 ! regulation of STAT protein import into nucleus relationship: positively_regulates GO:0007262 ! STAT protein import into nucleus [Term] id: GO:2000367 name: regulation of acrosomal vesicle exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol] synonym: "regulation of acrosomal granule exocytosis" RELATED [GOC:obol] synonym: "regulation of acrosome exocytosis" EXACT [GOC:obol] is_a: GO:0060046 ! regulation of acrosome reaction relationship: regulates GO:0060478 ! acrosomal vesicle exocytosis [Term] id: GO:2000368 name: positive regulation of acrosomal vesicle exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol] synonym: "positive regulation of acrosomal granule exocytosis" RELATED [GOC:obol] synonym: "positive regulation of acrosome exocytosis" EXACT [GOC:obol] is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis is_a: GO:2000243 ! positive regulation of reproductive process is_a: GO:2000367 ! regulation of acrosomal vesicle exocytosis relationship: positively_regulates GO:0060478 ! acrosomal vesicle exocytosis [Term] id: GO:2000369 name: regulation of clathrin-mediated endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:mah] synonym: "regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol] synonym: "regulation of clathrin-dependent endocytosis" EXACT [GOC:obol] is_a: GO:0030100 ! regulation of endocytosis relationship: regulates GO:0072583 ! clathrin-mediated endocytosis [Term] id: GO:2000370 name: positive regulation of clathrin-mediated endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:BHF, GOC:mah] synonym: "positive regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol] synonym: "positive regulation of clathrin-dependent endocytosis" EXACT [GOC:obol] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:2000369 ! regulation of clathrin-mediated endocytosis relationship: positively_regulates GO:0072583 ! clathrin-mediated endocytosis [Term] id: GO:2000371 name: regulation of DNA topoisomerase (ATP-hydrolyzing) activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] synonym: "regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol] synonym: "regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol] synonym: "regulation of DNA gyrase activity" EXACT [GOC:obol] synonym: "regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol] synonym: "regulation of DNA topoisomerase II" RELATED [GOC:obol] synonym: "regulation of DNA topoisomerase IV activity" EXACT [GOC:obol] synonym: "regulation of DNA topoisomerase type II activity" EXACT [GOC:obol] synonym: "regulation of DNA-gyrase activity" EXACT [GOC:obol] synonym: "regulation of topoisomerase" RELATED [GOC:obol] synonym: "regulation of topoisomerase II" EXACT [GOC:obol] synonym: "regulation of type II DNA topoisomerase activity" EXACT [GOC:obol] is_a: GO:0010911 ! regulation of isomerase activity is_a: GO:0051101 ! regulation of DNA binding [Term] id: GO:2000372 name: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] synonym: "negative regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol] synonym: "negative regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol] synonym: "negative regulation of DNA gyrase activity" EXACT [GOC:obol] synonym: "negative regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol] synonym: "negative regulation of DNA topoisomerase II" RELATED [GOC:obol] synonym: "negative regulation of DNA topoisomerase IV activity" EXACT [GOC:obol] synonym: "negative regulation of DNA topoisomerase type II activity" EXACT [GOC:obol] synonym: "negative regulation of DNA-gyrase activity" EXACT [GOC:obol] synonym: "negative regulation of topoisomerase" RELATED [GOC:obol] synonym: "negative regulation of topoisomerase II" EXACT [GOC:obol] synonym: "negative regulation of type II DNA topoisomerase activity" EXACT [GOC:obol] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0043392 ! negative regulation of DNA binding is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity [Term] id: GO:2000373 name: positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] synonym: "positive regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol] synonym: "positive regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol] synonym: "positive regulation of DNA gyrase activity" EXACT [GOC:obol] synonym: "positive regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol] synonym: "positive regulation of DNA topoisomerase II" RELATED [GOC:obol] synonym: "positive regulation of DNA topoisomerase IV activity" EXACT [GOC:obol] synonym: "positive regulation of DNA topoisomerase type II activity" EXACT [GOC:obol] synonym: "positive regulation of DNA-gyrase activity" EXACT [GOC:obol] synonym: "positive regulation of topoisomerase" RELATED [GOC:obol] synonym: "positive regulation of topoisomerase II" EXACT [GOC:obol] synonym: "positive regulation of type II DNA topoisomerase activity" EXACT [GOC:obol] is_a: GO:0010912 ! positive regulation of isomerase activity is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity [Term] id: GO:2000374 name: regulation of oxygen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0072592 ! oxygen metabolic process [Term] id: GO:2000375 name: negative regulation of oxygen metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "negative regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "negative regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process relationship: negatively_regulates GO:0072592 ! oxygen metabolic process [Term] id: GO:2000376 name: positive regulation of oxygen metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "positive regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "positive regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process relationship: positively_regulates GO:0072592 ! oxygen metabolic process [Term] id: GO:2000377 name: regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:2000378 name: negative regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "negative regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "negative regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process relationship: negatively_regulates GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:2000379 name: positive regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "positive regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "positive regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process relationship: positively_regulates GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:2000380 name: regulation of mesoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0007498 ! mesoderm development [Term] id: GO:2000381 name: negative regulation of mesoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development relationship: negatively_regulates GO:0007498 ! mesoderm development [Term] id: GO:2000382 name: positive regulation of mesoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development relationship: positively_regulates GO:0007498 ! mesoderm development [Term] id: GO:2000383 name: regulation of ectoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0007398 ! ectoderm development [Term] id: GO:2000384 name: negative regulation of ectoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development relationship: negatively_regulates GO:0007398 ! ectoderm development [Term] id: GO:2000385 name: positive regulation of ectoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development relationship: positively_regulates GO:0007398 ! ectoderm development [Term] id: GO:2000386 name: positive regulation of ovarian follicle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ovarian follicle development." [GOC:obol] synonym: "positive regulation of follicular phase" RELATED [GOC:obol] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000354 ! regulation of ovarian follicle development relationship: positively_regulates GO:0001541 ! ovarian follicle development [Term] id: GO:2000387 name: regulation of antral ovarian follicle growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000354 ! regulation of ovarian follicle development relationship: regulates GO:0001547 ! antral ovarian follicle growth [Term] id: GO:2000388 name: positive regulation of antral ovarian follicle growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:2000243 ! positive regulation of reproductive process is_a: GO:2000387 ! regulation of antral ovarian follicle growth relationship: positively_regulates GO:0001547 ! antral ovarian follicle growth [Term] id: GO:2000389 name: regulation of neutrophil extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil extravasation." [GOC:mah] is_a: GO:0002691 ! regulation of cellular extravasation relationship: regulates GO:0072672 ! neutrophil extravasation [Term] id: GO:2000390 name: negative regulation of neutrophil extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah] is_a: GO:0002692 ! negative regulation of cellular extravasation is_a: GO:2000389 ! regulation of neutrophil extravasation relationship: negatively_regulates GO:0072672 ! neutrophil extravasation [Term] id: GO:2000391 name: positive regulation of neutrophil extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah] is_a: GO:0002693 ! positive regulation of cellular extravasation is_a: GO:2000389 ! regulation of neutrophil extravasation relationship: positively_regulates GO:0072672 ! neutrophil extravasation [Term] id: GO:2000392 name: regulation of lamellipodium morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis." [GOC:mah] synonym: "regulation of lamellipodium organization" RELATED [GOC:obol] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0031344 ! regulation of cell projection organization relationship: regulates GO:0072673 ! lamellipodium morphogenesis [Term] id: GO:2000393 name: negative regulation of lamellipodium morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah] synonym: "negative regulation of lamellipodium organization" RELATED [GOC:obol] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000392 ! regulation of lamellipodium morphogenesis relationship: negatively_regulates GO:0072673 ! lamellipodium morphogenesis [Term] id: GO:2000394 name: positive regulation of lamellipodium morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah] synonym: "positive regulation of lamellipodium organization" RELATED [GOC:obol] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000392 ! regulation of lamellipodium morphogenesis relationship: positively_regulates GO:0072673 ! lamellipodium morphogenesis [Term] id: GO:2000395 name: regulation of ubiquitin-dependent endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah] synonym: "regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol] is_a: GO:0030100 ! regulation of endocytosis relationship: regulates GO:0070086 ! ubiquitin-dependent endocytosis [Term] id: GO:2000396 name: negative regulation of ubiquitin-dependent endocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah] synonym: "negative regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis relationship: negatively_regulates GO:0070086 ! ubiquitin-dependent endocytosis [Term] id: GO:2000397 name: positive regulation of ubiquitin-dependent endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah] synonym: "positive regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis relationship: positively_regulates GO:0070086 ! ubiquitin-dependent endocytosis [Term] id: GO:2000398 name: regulation of thymocyte aggregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thymocyte aggregation." [GOC:mah] synonym: "regulation of immature T cell aggregation" RELATED [GOC:obol] synonym: "regulation of immature T-cell aggregation" RELATED [GOC:obol] synonym: "regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol] synonym: "regulation of T cell precursor aggregation" EXACT [GOC:obol] synonym: "regulation of thymic lymphocyte aggregation" EXACT [GOC:obol] is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion relationship: regulates GO:0071594 ! thymocyte aggregation [Term] id: GO:2000399 name: negative regulation of thymocyte aggregation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah] synonym: "negative regulation of immature T cell aggregation" RELATED [GOC:obol] synonym: "negative regulation of immature T-cell aggregation" RELATED [GOC:obol] synonym: "negative regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol] synonym: "negative regulation of T cell precursor aggregation" EXACT [GOC:obol] synonym: "negative regulation of thymic lymphocyte aggregation" EXACT [GOC:obol] is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion is_a: GO:2000398 ! regulation of thymocyte aggregation relationship: negatively_regulates GO:0071594 ! thymocyte aggregation [Term] id: GO:2000400 name: positive regulation of thymocyte aggregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah] synonym: "positive regulation of immature T cell aggregation" RELATED [GOC:obol] synonym: "positive regulation of immature T-cell aggregation" RELATED [GOC:obol] synonym: "positive regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol] synonym: "positive regulation of T cell precursor aggregation" EXACT [GOC:obol] synonym: "positive regulation of thymic lymphocyte aggregation" EXACT [GOC:obol] is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion is_a: GO:2000398 ! regulation of thymocyte aggregation relationship: positively_regulates GO:0071594 ! thymocyte aggregation [Term] id: GO:2000401 name: regulation of lymphocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0002685 ! regulation of leukocyte migration relationship: regulates GO:0072676 ! lymphocyte migration [Term] id: GO:2000402 name: negative regulation of lymphocyte migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:2000401 ! regulation of lymphocyte migration relationship: negatively_regulates GO:0072676 ! lymphocyte migration [Term] id: GO:2000403 name: positive regulation of lymphocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:2000401 ! regulation of lymphocyte migration relationship: positively_regulates GO:0072676 ! lymphocyte migration [Term] id: GO:2000404 name: regulation of T cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "regulation of T-cell migration" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000401 ! regulation of lymphocyte migration relationship: regulates GO:0072678 ! T cell migration [Term] id: GO:2000405 name: negative regulation of T cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "negative regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "negative regulation of T-cell migration" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000402 ! negative regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration relationship: negatively_regulates GO:0072678 ! T cell migration [Term] id: GO:2000406 name: positive regulation of T cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "positive regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "positive regulation of T-cell migration" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000403 ! positive regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration relationship: positively_regulates GO:0072678 ! T cell migration [Term] id: GO:2000407 name: regulation of T cell extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell extravasation." [GOC:mah] synonym: "regulation of T lymphocyte extravasation" EXACT [GOC:obol] synonym: "regulation of T-cell extravasation" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte extravasation" EXACT [GOC:obol] is_a: GO:0002691 ! regulation of cellular extravasation is_a: GO:2000404 ! regulation of T cell migration relationship: regulates GO:0072683 ! T cell extravasation [Term] id: GO:2000408 name: negative regulation of T cell extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah] synonym: "negative regulation of T lymphocyte extravasation" EXACT [GOC:obol] synonym: "negative regulation of T-cell extravasation" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte extravasation" EXACT [GOC:obol] is_a: GO:0002692 ! negative regulation of cellular extravasation is_a: GO:2000405 ! negative regulation of T cell migration is_a: GO:2000407 ! regulation of T cell extravasation relationship: negatively_regulates GO:0072683 ! T cell extravasation [Term] id: GO:2000409 name: positive regulation of T cell extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah] synonym: "positive regulation of T lymphocyte extravasation" EXACT [GOC:obol] synonym: "positive regulation of T-cell extravasation" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte extravasation" EXACT [GOC:obol] is_a: GO:0002693 ! positive regulation of cellular extravasation is_a: GO:2000406 ! positive regulation of T cell migration is_a: GO:2000407 ! regulation of T cell extravasation relationship: positively_regulates GO:0072683 ! T cell extravasation [Term] id: GO:2000410 name: regulation of thymocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thymocyte migration." [GOC:mah] synonym: "regulation of immature T cell migration" RELATED [GOC:obol] synonym: "regulation of immature T lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of immature T-cell migration" RELATED [GOC:obol] synonym: "regulation of immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000404 ! regulation of T cell migration relationship: regulates GO:0072679 ! thymocyte migration [Term] id: GO:2000411 name: negative regulation of thymocyte migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte migration." [GOC:mah] synonym: "negative regulation of immature T cell migration" RELATED [GOC:obol] synonym: "negative regulation of immature T lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of immature T-cell migration" RELATED [GOC:obol] synonym: "negative regulation of immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000405 ! negative regulation of T cell migration is_a: GO:2000410 ! regulation of thymocyte migration relationship: negatively_regulates GO:0072679 ! thymocyte migration [Term] id: GO:2000412 name: positive regulation of thymocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thymocyte migration." [GOC:mah] synonym: "positive regulation of immature T cell migration" RELATED [GOC:obol] synonym: "positive regulation of immature T lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of immature T-cell migration" RELATED [GOC:obol] synonym: "positive regulation of immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000406 ! positive regulation of T cell migration is_a: GO:2000410 ! regulation of thymocyte migration relationship: positively_regulates GO:0072679 ! thymocyte migration [Term] id: GO:2000413 name: regulation of fibronectin-dependent thymocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:mah] synonym: "regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol] synonym: "regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol] synonym: "regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000410 ! regulation of thymocyte migration relationship: regulates GO:0072681 ! fibronectin-dependent thymocyte migration [Term] id: GO:2000414 name: negative regulation of fibronectin-dependent thymocyte migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah] synonym: "negative regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol] synonym: "negative regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol] synonym: "negative regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000411 ! negative regulation of thymocyte migration is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration relationship: negatively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration [Term] id: GO:2000415 name: positive regulation of fibronectin-dependent thymocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah] synonym: "positive regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol] synonym: "positive regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol] synonym: "positive regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000412 ! positive regulation of thymocyte migration is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration relationship: positively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration [Term] id: GO:2000416 name: regulation of eosinophil migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil migration." [GOC:mah] is_a: GO:0002685 ! regulation of leukocyte migration relationship: regulates GO:0072677 ! eosinophil migration [Term] id: GO:2000417 name: negative regulation of eosinophil migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration." [GOC:mah] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:2000416 ! regulation of eosinophil migration relationship: negatively_regulates GO:0072677 ! eosinophil migration [Term] id: GO:2000418 name: positive regulation of eosinophil migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil migration." [GOC:mah] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:2000416 ! regulation of eosinophil migration relationship: positively_regulates GO:0072677 ! eosinophil migration [Term] id: GO:2000419 name: regulation of eosinophil extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil extravasation." [GOC:mah] is_a: GO:0002691 ! regulation of cellular extravasation is_a: GO:2000416 ! regulation of eosinophil migration relationship: regulates GO:0072682 ! eosinophil extravasation [Term] id: GO:2000420 name: negative regulation of eosinophil extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah] is_a: GO:0002692 ! negative regulation of cellular extravasation is_a: GO:2000417 ! negative regulation of eosinophil migration is_a: GO:2000419 ! regulation of eosinophil extravasation relationship: negatively_regulates GO:0072682 ! eosinophil extravasation [Term] id: GO:2000421 name: positive regulation of eosinophil extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah] is_a: GO:0002693 ! positive regulation of cellular extravasation is_a: GO:2000418 ! positive regulation of eosinophil migration is_a: GO:2000419 ! regulation of eosinophil extravasation relationship: positively_regulates GO:0072682 ! eosinophil extravasation [Term] id: GO:2000422 name: regulation of eosinophil chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:2000416 ! regulation of eosinophil migration relationship: regulates GO:0048245 ! eosinophil chemotaxis [Term] id: GO:2000423 name: negative regulation of eosinophil chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:2000417 ! negative regulation of eosinophil migration is_a: GO:2000422 ! regulation of eosinophil chemotaxis relationship: negatively_regulates GO:0048245 ! eosinophil chemotaxis [Term] id: GO:2000424 name: positive regulation of eosinophil chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:2000418 ! positive regulation of eosinophil migration is_a: GO:2000422 ! regulation of eosinophil chemotaxis relationship: positively_regulates GO:0048245 ! eosinophil chemotaxis [Term] id: GO:2000425 name: regulation of apoptotic cell clearance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] synonym: "regulation of apoptotic cell removal" EXACT [GOC:obol] synonym: "regulation of efferocytosis" EXACT [GOC:obol] synonym: "regulation of programmed cell clearance" EXACT [GOC:obol] is_a: GO:0050764 ! regulation of phagocytosis relationship: regulates GO:0043277 ! apoptotic cell clearance [Term] id: GO:2000426 name: negative regulation of apoptotic cell clearance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] synonym: "negative regulation of apoptotic cell removal" EXACT [GOC:obol] synonym: "negative regulation of efferocytosis" EXACT [GOC:obol] synonym: "negative regulation of programmed cell clearance" EXACT [GOC:obol] is_a: GO:0050765 ! negative regulation of phagocytosis is_a: GO:2000425 ! regulation of apoptotic cell clearance relationship: negatively_regulates GO:0043277 ! apoptotic cell clearance [Term] id: GO:2000427 name: positive regulation of apoptotic cell clearance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] synonym: "positive regulation of apoptotic cell removal" EXACT [GOC:obol] synonym: "positive regulation of efferocytosis" EXACT [GOC:obol] synonym: "positive regulation of programmed cell clearance" EXACT [GOC:obol] is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:2000425 ! regulation of apoptotic cell clearance relationship: positively_regulates GO:0043277 ! apoptotic cell clearance [Term] id: GO:2000428 name: regulation of neutrophil aggregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil aggregation." [GOC:BHF] synonym: "regulation of neutrocyte aggregation" EXACT [GOC:obol] synonym: "regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol] synonym: "regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol] is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion relationship: regulates GO:0070488 ! neutrophil aggregation [Term] id: GO:2000429 name: negative regulation of neutrophil aggregation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation." [GOC:BHF] synonym: "negative regulation of neutrocyte aggregation" EXACT [GOC:obol] synonym: "negative regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol] synonym: "negative regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol] is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion is_a: GO:2000428 ! regulation of neutrophil aggregation relationship: negatively_regulates GO:0070488 ! neutrophil aggregation [Term] id: GO:2000430 name: positive regulation of neutrophil aggregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil aggregation." [GOC:BHF] synonym: "positive regulation of neutrocyte aggregation" EXACT [GOC:obol] synonym: "positive regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol] synonym: "positive regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol] is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion is_a: GO:2000428 ! regulation of neutrophil aggregation relationship: positively_regulates GO:0070488 ! neutrophil aggregation [Term] id: GO:2000431 name: regulation of cytokinesis, actomyosin contractile ring assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] synonym: "regulation of contractile ring assembly" EXACT [GOC:obol] is_a: GO:0032954 ! regulation of cytokinetic process is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0071775 ! regulation of cell cycle cytokinesis relationship: regulates GO:0000915 ! cytokinesis, actomyosin contractile ring assembly [Term] id: GO:2000432 name: negative regulation of cytokinesis, actomyosin contractile ring assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] synonym: "negative regulation of contractile ring assembly" EXACT [GOC:obol] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly relationship: negatively_regulates GO:0000915 ! cytokinesis, actomyosin contractile ring assembly [Term] id: GO:2000433 name: positive regulation of cytokinesis, actomyosin contractile ring assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] synonym: "positive regulation of contractile ring assembly" EXACT [GOC:obol] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly relationship: positively_regulates GO:0000915 ! cytokinesis, actomyosin contractile ring assembly [Term] id: GO:2000434 name: regulation of protein neddylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein neddylation." [GOC:obol] synonym: "regulation of RUB1-protein conjugation" EXACT [GOC:obol] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0045116 ! protein neddylation [Term] id: GO:2000435 name: negative regulation of protein neddylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol] synonym: "negative regulation of RUB1-protein conjugation" EXACT [GOC:obol] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:2000434 ! regulation of protein neddylation relationship: negatively_regulates GO:0045116 ! protein neddylation [Term] id: GO:2000436 name: positive regulation of protein neddylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein neddylation." [GOC:obol] synonym: "positive regulation of RUB1-protein conjugation" EXACT [GOC:obol] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:2000434 ! regulation of protein neddylation relationship: positively_regulates GO:0045116 ! protein neddylation [Term] id: GO:2000437 name: regulation of monocyte extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monocyte extravasation." [GOC:obol] is_a: GO:0002691 ! regulation of cellular extravasation relationship: regulates GO:0035696 ! monocyte extravasation [Term] id: GO:2000438 name: negative regulation of monocyte extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte extravasation." [GOC:obol] is_a: GO:0002692 ! negative regulation of cellular extravasation is_a: GO:2000437 ! regulation of monocyte extravasation relationship: negatively_regulates GO:0035696 ! monocyte extravasation [Term] id: GO:2000439 name: positive regulation of monocyte extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monocyte extravasation." [GOC:obol] is_a: GO:0002693 ! positive regulation of cellular extravasation is_a: GO:2000437 ! regulation of monocyte extravasation relationship: positively_regulates GO:0035696 ! monocyte extravasation [Term] id: GO:2000440 name: regulation of toll-like receptor 15 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol] synonym: "regulation of TLR15 signaling pathway" EXACT [GOC:obol] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0035681 ! toll-like receptor 15 signaling pathway [Term] id: GO:2000441 name: negative regulation of toll-like receptor 15 signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol] synonym: "negative regulation of TLR15 signaling pathway" EXACT [GOC:obol] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway relationship: negatively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway [Term] id: GO:2000442 name: positive regulation of toll-like receptor 15 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol] synonym: "positive regulation of TLR15 signaling pathway" EXACT [GOC:obol] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway relationship: positively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway [Term] id: GO:2000443 name: regulation of toll-like receptor 21 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol] synonym: "regulation of TLR21 signaling pathway" EXACT [GOC:obol] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway relationship: regulates GO:0035682 ! toll-like receptor 21 signaling pathway [Term] id: GO:2000444 name: negative regulation of toll-like receptor 21 signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol] synonym: "negative regulation of TLR21 signaling pathway" EXACT [GOC:obol] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway relationship: negatively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway [Term] id: GO:2000445 name: positive regulation of toll-like receptor 21 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol] synonym: "positive regulation of TLR21 signaling pathway" EXACT [GOC:obol] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway relationship: positively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway [Term] id: GO:2000446 name: regulation of macrophage migration inhibitory factor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol] synonym: "regulation of MIF signaling pathway" EXACT [GOC:obol] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway relationship: regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway [Term] id: GO:2000447 name: negative regulation of macrophage migration inhibitory factor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol] synonym: "negative regulation of MIF signaling pathway" EXACT [GOC:obol] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway relationship: negatively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway [Term] id: GO:2000448 name: positive regulation of macrophage migration inhibitory factor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol] synonym: "positive regulation of MIF signaling pathway" EXACT [GOC:obol] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway relationship: positively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway [Term] id: GO:2000449 name: regulation of CD8-positive, alpha-beta T cell extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol] is_a: GO:2000407 ! regulation of T cell extravasation relationship: regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation [Term] id: GO:2000450 name: negative regulation of CD8-positive, alpha-beta T cell extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol] is_a: GO:2000408 ! negative regulation of T cell extravasation is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation relationship: negatively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation [Term] id: GO:2000451 name: positive regulation of CD8-positive, alpha-beta T cell extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol] is_a: GO:2000409 ! positive regulation of T cell extravasation is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation relationship: positively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation [Term] id: GO:2000452 name: regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol] is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation relationship: regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation [Term] id: GO:2000453 name: negative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol] is_a: GO:2000450 ! negative regulation of CD8-positive, alpha-beta T cell extravasation is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation relationship: negatively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation [Term] id: GO:2000454 name: positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol] is_a: GO:2000451 ! positive regulation of CD8-positive, alpha-beta T cell extravasation is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation relationship: positively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation [Term] id: GO:2000455 name: regulation of T-helper 17 cell extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol] is_a: GO:2000407 ! regulation of T cell extravasation relationship: regulates GO:0035699 ! T-helper 17 cell extravasation [Term] id: GO:2000456 name: negative regulation of T-helper 17 cell extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol] is_a: GO:2000408 ! negative regulation of T cell extravasation is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation relationship: negatively_regulates GO:0035699 ! T-helper 17 cell extravasation [Term] id: GO:2000457 name: positive regulation of T-helper 17 cell extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol] is_a: GO:2000409 ! positive regulation of T cell extravasation is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation relationship: positively_regulates GO:0035699 ! T-helper 17 cell extravasation [Term] id: GO:2000458 name: regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0050920 ! regulation of chemotaxis relationship: regulates GO:0035700 ! astrocyte chemotaxis [Term] id: GO:2000459 name: negative regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:2000458 ! regulation of astrocyte chemotaxis relationship: negatively_regulates GO:0035700 ! astrocyte chemotaxis [Term] id: GO:2000460 name: regulation of eukaryotic cell surface binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol] is_a: GO:0051098 ! regulation of binding [Term] id: GO:2000461 name: negative regulation of eukaryotic cell surface binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol] is_a: GO:0051100 ! negative regulation of binding is_a: GO:2000460 ! regulation of eukaryotic cell surface binding [Term] id: GO:2000462 name: positive regulation of eukaryotic cell surface binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol] is_a: GO:0051099 ! positive regulation of binding is_a: GO:2000460 ! regulation of eukaryotic cell surface binding [Term] id: GO:2000463 name: positive regulation of excitatory postsynaptic membrane potential namespace: biological_process def: "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:bf, GOC:BHF] synonym: "positive regulation of EPSP" RELATED [GOC:bf, GOC:obol] is_a: GO:0045838 ! positive regulation of membrane potential is_a: GO:0060079 ! regulation of excitatory postsynaptic membrane potential [Term] id: GO:2000464 name: positive regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:2000458 ! regulation of astrocyte chemotaxis relationship: positively_regulates GO:0035700 ! astrocyte chemotaxis [Term] id: GO:2000465 name: regulation of glycogen (starch) synthase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol] synonym: "regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol] synonym: "regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] synonym: "regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "regulation of UDP-glycogen synthase activity" EXACT [GOC:obol] synonym: "regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol] synonym: "regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol] synonym: "regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] is_a: GO:0051338 ! regulation of transferase activity [Term] id: GO:2000466 name: negative regulation of glycogen (starch) synthase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol] synonym: "negative regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol] synonym: "negative regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] synonym: "negative regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "negative regulation of UDP-glycogen synthase activity" EXACT [GOC:obol] synonym: "negative regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol] synonym: "negative regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol] synonym: "negative regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "negative regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity [Term] id: GO:2000467 name: positive regulation of glycogen (starch) synthase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol] synonym: "positive regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol] synonym: "positive regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] synonym: "positive regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "positive regulation of UDP-glycogen synthase activity" EXACT [GOC:obol] synonym: "positive regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol] synonym: "positive regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol] synonym: "positive regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "positive regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity [Term] id: GO:2000468 name: regulation of peroxidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peroxidase activity." [GOC:obol] synonym: "regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol] synonym: "regulation of oxyperoxidase activity" EXACT [GOC:obol] synonym: "regulation of peroxidase reaction" EXACT [GOC:obol] is_a: GO:0051341 ! regulation of oxidoreductase activity [Term] id: GO:2000469 name: negative regulation of peroxidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity." [GOC:obol] synonym: "negative regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol] synonym: "negative regulation of oxyperoxidase activity" EXACT [GOC:obol] synonym: "negative regulation of peroxidase reaction" EXACT [GOC:obol] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:2000468 ! regulation of peroxidase activity [Term] id: GO:2000470 name: positive regulation of peroxidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peroxidase activity." [GOC:obol] synonym: "positive regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol] synonym: "positive regulation of oxyperoxidase activity" EXACT [GOC:obol] synonym: "positive regulation of peroxidase reaction" EXACT [GOC:obol] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:2000468 ! regulation of peroxidase activity [Term] id: GO:2000471 name: regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0035701 ! hematopoietic stem cell migration [Term] id: GO:2000472 name: negative regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "negative regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration relationship: negatively_regulates GO:0035701 ! hematopoietic stem cell migration [Term] id: GO:2000473 name: positive regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "positive regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration relationship: positively_regulates GO:0035701 ! hematopoietic stem cell migration [Term] id: GO:2000474 name: regulation of opioid receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol] is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway relationship: regulates GO:0038003 ! opioid receptor signaling pathway [Term] id: GO:2000475 name: negative regulation of opioid receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol] is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway is_a: GO:2000474 ! regulation of opioid receptor signaling pathway relationship: negatively_regulates GO:0038003 ! opioid receptor signaling pathway [Term] id: GO:2000476 name: positive regulation of opioid receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol] is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway is_a: GO:2000474 ! regulation of opioid receptor signaling pathway relationship: positively_regulates GO:0038003 ! opioid receptor signaling pathway [Term] id: GO:2000477 name: regulation of metanephric glomerular visceral epithelial cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol] synonym: "regulation of metanephric podocyte development" RELATED [GOC:obol] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0060284 ! regulation of cell development is_a: GO:0072298 ! regulation of metanephric glomerulus development relationship: regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development [Term] id: GO:2000478 name: positive regulation of metanephric glomerular visceral epithelial cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol] synonym: "positive regulation of metanephric podocyte development" RELATED [GOC:obol] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:2000477 ! regulation of metanephric glomerular visceral epithelial cell development relationship: positively_regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development [Term] id: GO:2000479 name: regulation of cAMP-dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol] synonym: "regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol] synonym: "regulation of AMPK" RELATED [GOC:obol] synonym: "regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol] synonym: "regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol] synonym: "regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "regulation of PKA" RELATED [GOC:obol] synonym: "regulation of PKA C" RELATED [GOC:obol] synonym: "regulation of protein kinase A activity" RELATED [GOC:obol] synonym: "regulation of STK22" RELATED [GOC:obol] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity [Term] id: GO:2000480 name: negative regulation of cAMP-dependent protein kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of AMPK" RELATED [GOC:obol] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of PKA" RELATED [GOC:obol] synonym: "negative regulation of PKA C" RELATED [GOC:obol] synonym: "negative regulation of protein kinase A activity" RELATED [GOC:obol] synonym: "negative regulation of STK22" RELATED [GOC:obol] is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity [Term] id: GO:2000481 name: positive regulation of cAMP-dependent protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol] synonym: "positive regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "positive regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "positive regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol] synonym: "positive regulation of AMPK" RELATED [GOC:obol] synonym: "positive regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol] synonym: "positive regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol] synonym: "positive regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "positive regulation of PKA" RELATED [GOC:obol] synonym: "positive regulation of PKA C" RELATED [GOC:obol] synonym: "positive regulation of protein kinase A activity" RELATED [GOC:obol] synonym: "positive regulation of STK22" RELATED [GOC:obol] is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity [Term] id: GO:2000482 name: regulation of interleukin-8 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-8 secretion." [GOC:obol] synonym: "regulation of IL-8 secretion" EXACT [GOC:obol] is_a: GO:0032677 ! regulation of interleukin-8 production is_a: GO:0050707 ! regulation of cytokine secretion relationship: regulates GO:0072606 ! interleukin-8 secretion [Term] id: GO:2000483 name: negative regulation of interleukin-8 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion." [GOC:obol] synonym: "negative regulation of IL-8 secretion" EXACT [GOC:obol] is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:2000482 ! regulation of interleukin-8 secretion relationship: negatively_regulates GO:0072606 ! interleukin-8 secretion [Term] id: GO:2000484 name: positive regulation of interleukin-8 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion." [GOC:obol] synonym: "positive regulation of IL-8 secretion" EXACT [GOC:obol] is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:2000482 ! regulation of interleukin-8 secretion relationship: positively_regulates GO:0072606 ! interleukin-8 secretion [Term] id: GO:2000485 name: regulation of glutamine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamine transport." [GOC:obol] synonym: "regulation of L-glutamine transport" RELATED [GOC:obol] is_a: GO:0051955 ! regulation of amino acid transport relationship: regulates GO:0006868 ! glutamine transport [Term] id: GO:2000486 name: negative regulation of glutamine transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamine transport." [GOC:obol] synonym: "negative regulation of L-glutamine transport" RELATED [GOC:obol] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:2000485 ! regulation of glutamine transport relationship: negatively_regulates GO:0006868 ! glutamine transport [Term] id: GO:2000487 name: positive regulation of glutamine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamine transport." [GOC:obol] synonym: "positive regulation of L-glutamine transport" RELATED [GOC:obol] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:2000485 ! regulation of glutamine transport relationship: positively_regulates GO:0006868 ! glutamine transport [Term] id: GO:2000488 name: positive regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of brassinosteroid biosynthetic process." [GOC:obol] synonym: "positive regulation of brassinosteroid anabolism" EXACT [GOC:obol] synonym: "positive regulation of brassinosteroid biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of brassinosteroid formation" EXACT [GOC:obol] synonym: "positive regulation of brassinosteroid synthesis" EXACT [GOC:obol] is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process relationship: positively_regulates GO:0016132 ! brassinosteroid biosynthetic process [Term] id: GO:2000489 name: regulation of hepatic stellate cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] is_a: GO:0050865 ! regulation of cell activation relationship: regulates GO:0035733 ! hepatic stellate cell activation [Term] id: GO:2000490 name: negative regulation of hepatic stellate cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] is_a: GO:0050866 ! negative regulation of cell activation is_a: GO:2000489 ! regulation of hepatic stellate cell activation relationship: negatively_regulates GO:0035733 ! hepatic stellate cell activation [Term] id: GO:2000491 name: positive regulation of hepatic stellate cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:2000489 ! regulation of hepatic stellate cell activation relationship: positively_regulates GO:0035733 ! hepatic stellate cell activation [Term] id: GO:2000492 name: regulation of interleukin-18-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol] synonym: "regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway relationship: regulates GO:0035655 ! interleukin-18-mediated signaling pathway [Term] id: GO:2000493 name: negative regulation of interleukin-18-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol] synonym: "negative regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway relationship: negatively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway [Term] id: GO:2000494 name: positive regulation of interleukin-18-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol] synonym: "positive regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway relationship: positively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway [Term] id: GO:2000495 name: regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis [Term] id: GO:2000496 name: negative regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis relationship: negatively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis [Term] id: GO:2000497 name: positive regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis relationship: positively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis [Term] id: GO:2000498 name: regulation of induction of apoptosis in response to chemical stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:obol] synonym: "regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0031558 ! induction of apoptosis in response to chemical stimulus [Term] id: GO:2000499 name: negative regulation of induction of apoptosis in response to chemical stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:obol] synonym: "negative regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000498 ! regulation of induction of apoptosis in response to chemical stimulus relationship: negatively_regulates GO:0031558 ! induction of apoptosis in response to chemical stimulus [Term] id: GO:2000500 name: positive regulation of induction of apoptosis in response to chemical stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:obol] synonym: "positive regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2000498 ! regulation of induction of apoptosis in response to chemical stimulus relationship: positively_regulates GO:0031558 ! induction of apoptosis in response to chemical stimulus [Term] id: GO:2000501 name: regulation of natural killer cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:2000401 ! regulation of lymphocyte migration relationship: regulates GO:0035747 ! natural killer cell chemotaxis [Term] id: GO:2000502 name: negative regulation of natural killer cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:2000402 ! negative regulation of lymphocyte migration is_a: GO:2000501 ! regulation of natural killer cell chemotaxis relationship: negatively_regulates GO:0035747 ! natural killer cell chemotaxis [Term] id: GO:2000503 name: positive regulation of natural killer cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:2000403 ! positive regulation of lymphocyte migration is_a: GO:2000501 ! regulation of natural killer cell chemotaxis relationship: positively_regulates GO:0035747 ! natural killer cell chemotaxis [Term] id: GO:2000504 name: positive regulation of blood vessel remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling." [GOC:obol] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0060312 ! regulation of blood vessel remodeling relationship: positively_regulates GO:0001974 ! blood vessel remodeling [Term] id: GO:2000505 name: regulation of energy homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of energy homeostasis." [GOC:obol] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0097009 ! energy homeostasis [Term] id: GO:2000506 name: negative regulation of energy homeostasis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of energy homeostasis." [GOC:obol] is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000505 ! regulation of energy homeostasis relationship: negatively_regulates GO:0097009 ! energy homeostasis [Term] id: GO:2000507 name: positive regulation of energy homeostasis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of energy homeostasis." [GOC:obol] is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000505 ! regulation of energy homeostasis relationship: positively_regulates GO:0097009 ! energy homeostasis [Term] id: GO:2000508 name: regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002688 ! regulation of leukocyte chemotaxis relationship: regulates GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:2000509 name: negative regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:2000508 ! regulation of dendritic cell chemotaxis relationship: negatively_regulates GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:2000510 name: positive regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:2000508 ! regulation of dendritic cell chemotaxis relationship: positively_regulates GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:2000511 name: regulation of granzyme A production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granzyme A production." [GOC:obol] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: regulates GO:0035746 ! granzyme A production [Term] id: GO:2000512 name: negative regulation of granzyme A production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production." [GOC:obol] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:2000511 ! regulation of granzyme A production relationship: negatively_regulates GO:0035746 ! granzyme A production [Term] id: GO:2000513 name: positive regulation of granzyme A production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granzyme A production." [GOC:obol] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:2000511 ! regulation of granzyme A production relationship: positively_regulates GO:0035746 ! granzyme A production [Term] id: GO:2000514 name: regulation of CD4-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046634 ! regulation of alpha-beta T cell activation relationship: regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation [Term] id: GO:2000515 name: negative regulation of CD4-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation relationship: negatively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation [Term] id: GO:2000516 name: positive regulation of CD4-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation relationship: positively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation [Term] id: GO:2000517 name: regulation of T-helper 1 cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] synonym: "regulation of Th1 cell activation" EXACT [GOC:obol] is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation relationship: regulates GO:0035711 ! T-helper 1 cell activation [Term] id: GO:2000518 name: negative regulation of T-helper 1 cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] synonym: "negative regulation of Th1 cell activation" EXACT [GOC:obol] is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000517 ! regulation of T-helper 1 cell activation relationship: negatively_regulates GO:0035711 ! T-helper 1 cell activation [Term] id: GO:2000519 name: positive regulation of T-helper 1 cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] synonym: "positive regulation of Th1 cell activation" EXACT [GOC:obol] is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000517 ! regulation of T-helper 1 cell activation relationship: positively_regulates GO:0035711 ! T-helper 1 cell activation [Term] id: GO:2000520 name: regulation of immunological synapse formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immunological synapse formation." [GOC:obol] synonym: "regulation of formation of immunological synapse" EXACT [GOC:obol] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0051249 ! regulation of lymphocyte activation relationship: regulates GO:0001771 ! immunological synapse formation [Term] id: GO:2000521 name: negative regulation of immunological synapse formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation." [GOC:obol] synonym: "negative regulation of formation of immunological synapse" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000520 ! regulation of immunological synapse formation relationship: negatively_regulates GO:0001771 ! immunological synapse formation [Term] id: GO:2000522 name: positive regulation of immunological synapse formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immunological synapse formation." [GOC:obol] synonym: "positive regulation of formation of immunological synapse" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000520 ! regulation of immunological synapse formation relationship: positively_regulates GO:0001771 ! immunological synapse formation [Term] id: GO:2000523 name: regulation of T cell costimulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell costimulation." [GOC:obol] synonym: "regulation of T cell co-stimulation" EXACT [GOC:obol] synonym: "regulation of T lymphocyte costimulation" EXACT [GOC:obol] synonym: "regulation of T-cell co-stimulation" EXACT [GOC:obol] synonym: "regulation of T-cell costimulation" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte costimulation" EXACT [GOC:obol] is_a: GO:0002682 ! regulation of immune system process relationship: regulates GO:0031295 ! T cell costimulation [Term] id: GO:2000524 name: negative regulation of T cell costimulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell costimulation." [GOC:obol] synonym: "negative regulation of T cell co-stimulation" EXACT [GOC:obol] synonym: "negative regulation of T lymphocyte costimulation" EXACT [GOC:obol] synonym: "negative regulation of T-cell co-stimulation" EXACT [GOC:obol] synonym: "negative regulation of T-cell costimulation" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte costimulation" EXACT [GOC:obol] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:2000523 ! regulation of T cell costimulation relationship: negatively_regulates GO:0031295 ! T cell costimulation [Term] id: GO:2000525 name: positive regulation of T cell costimulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell costimulation." [GOC:obol] synonym: "positive regulation of T cell co-stimulation" EXACT [GOC:obol] synonym: "positive regulation of T lymphocyte costimulation" EXACT [GOC:obol] synonym: "positive regulation of T-cell co-stimulation" EXACT [GOC:obol] synonym: "positive regulation of T-cell costimulation" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte costimulation" EXACT [GOC:obol] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:2000523 ! regulation of T cell costimulation relationship: positively_regulates GO:0031295 ! T cell costimulation [Term] id: GO:2000526 name: positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation namespace: biological_process def: "Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation." [GOC:obol] synonym: "positive regulation of glycoprotein biosynthetic process of formation of immunological synapse" EXACT [GOC:obol] synonym: "positive regulation of glycoprotein biosynthetic process of immunological synapse formation" EXACT [GOC:obol] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process relationship: part_of GO:0001771 ! immunological synapse formation [Term] id: GO:2000527 name: regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000508 ! regulation of dendritic cell chemotaxis relationship: regulates GO:0002408 ! myeloid dendritic cell chemotaxis [Term] id: GO:2000528 name: negative regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis relationship: negatively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis [Term] id: GO:2000529 name: positive regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis relationship: positively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis [Term] id: GO:2000530 name: positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of regulation of insulin secretion involved in cellular response to glucose stimulus." [GOC:obol] synonym: "positive regulation of regulation of insulin secretion in response to glucose" EXACT [GOC:obol] is_obsolete: true [Term] id: GO:2000531 name: regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process namespace: biological_process def: "Any regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process." [GOC:dph] synonym: "regulation of transcription from Pol II promoter of fatty acid anabolism" EXACT [GOC:obol] synonym: "regulation of transcription from Pol II promoter of fatty acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of transcription from Pol II promoter of fatty acid biosynthetic process" EXACT [GOC:obol] synonym: "regulation of transcription from Pol II promoter of fatty acid formation" EXACT [GOC:obol] synonym: "regulation of transcription from Pol II promoter of fatty acid synthesis" EXACT [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter of fatty acid anabolism" EXACT [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter of fatty acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter of fatty acid biosynthetic process" EXACT [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter of fatty acid formation" EXACT [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter of fatty acid synthesis" EXACT [GOC:obol] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:2000532 name: regulation of renal albumin absorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of renal albumin absorption." [GOC:obol] is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0097018 ! renal albumin absorption [Term] id: GO:2000533 name: negative regulation of renal albumin absorption namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption." [GOC:obol] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000532 ! regulation of renal albumin absorption relationship: negatively_regulates GO:0097018 ! renal albumin absorption [Term] id: GO:2000534 name: positive regulation of renal albumin absorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of renal albumin absorption." [GOC:obol] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000532 ! regulation of renal albumin absorption relationship: positively_regulates GO:0097018 ! renal albumin absorption [Term] id: GO:2000535 name: regulation of entry of bacterium into host cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol] synonym: "regulation of bacterial entry into host cell" EXACT [GOC:obol] synonym: "regulation of invasion of bacteria into host cell" EXACT [GOC:obol] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism relationship: regulates GO:0035635 ! entry of bacterium into host cell [Term] id: GO:2000536 name: negative regulation of entry of bacterium into host cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol] synonym: "negative regulation of bacterial entry into host cell" EXACT [GOC:obol] synonym: "negative regulation of invasion of bacteria into host cell" EXACT [GOC:obol] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:2000535 ! regulation of entry of bacterium into host cell relationship: negatively_regulates GO:0035635 ! entry of bacterium into host cell [Term] id: GO:2000537 name: regulation of B cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell chemotaxis." [GOC:obol] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:2000401 ! regulation of lymphocyte migration relationship: regulates GO:0035754 ! B cell chemotaxis [Term] id: GO:2000538 name: positive regulation of B cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B cell chemotaxis." [GOC:obol] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:2000403 ! positive regulation of lymphocyte migration is_a: GO:2000537 ! regulation of B cell chemotaxis relationship: positively_regulates GO:0035754 ! B cell chemotaxis [Term] id: GO:2000539 name: regulation of protein geranylgeranylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein geranylgeranylation." [GOC:obol] synonym: "regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol] synonym: "regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0018344 ! protein geranylgeranylation [Term] id: GO:2000540 name: negative regulation of protein geranylgeranylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation." [GOC:obol] synonym: "negative regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol] synonym: "negative regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:2000539 ! regulation of protein geranylgeranylation relationship: negatively_regulates GO:0018344 ! protein geranylgeranylation [Term] id: GO:2000541 name: positive regulation of protein geranylgeranylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation." [GOC:obol] synonym: "positive regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol] synonym: "positive regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:2000539 ! regulation of protein geranylgeranylation relationship: positively_regulates GO:0018344 ! protein geranylgeranylation [Term] id: GO:2000542 name: negative regulation of gastrulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0007369 ! gastrulation [Term] id: GO:2000543 name: positive regulation of gastrulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0007369 ! gastrulation [Term] id: GO:2000544 name: regulation of endothelial cell chemotaxis to fibroblast growth factor namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus relationship: regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor [Term] id: GO:2000545 name: negative regulation of endothelial cell chemotaxis to fibroblast growth factor namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor relationship: negatively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor [Term] id: GO:2000546 name: positive regulation of endothelial cell chemotaxis to fibroblast growth factor namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor relationship: positively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor [Term] id: GO:2000547 name: regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0060491 ! regulation of cell projection assembly relationship: regulates GO:0097026 ! dendritic cell dendrite assembly [Term] id: GO:2000548 name: negative regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "negative regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly relationship: negatively_regulates GO:0097026 ! dendritic cell dendrite assembly [Term] id: GO:2000549 name: positive regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "positive regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly relationship: positively_regulates GO:0097026 ! dendritic cell dendrite assembly [Term] id: GO:2000550 name: negative regulation of B cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis." [GOC:obol] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:2000402 ! negative regulation of lymphocyte migration is_a: GO:2000537 ! regulation of B cell chemotaxis relationship: negatively_regulates GO:0035754 ! B cell chemotaxis [Term] id: GO:2000551 name: regulation of T-helper 2 cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] synonym: "regulation of Th2 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002724 ! regulation of T cell cytokine production is_a: GO:0002828 ! regulation of type 2 immune response relationship: regulates GO:0035745 ! T-helper 2 cell cytokine production [Term] id: GO:2000552 name: negative regulation of T-helper 2 cell cytokine production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] synonym: "negative regulation of Th2 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002725 ! negative regulation of T cell cytokine production is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production relationship: negatively_regulates GO:0035745 ! T-helper 2 cell cytokine production [Term] id: GO:2000553 name: positive regulation of T-helper 2 cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] synonym: "positive regulation of Th2 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002726 ! positive regulation of T cell cytokine production is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production relationship: positively_regulates GO:0035745 ! T-helper 2 cell cytokine production [Term] id: GO:2000554 name: regulation of T-helper 1 cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] synonym: "regulation of Th1 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002724 ! regulation of T cell cytokine production is_a: GO:0002825 ! regulation of T-helper 1 type immune response relationship: regulates GO:0035744 ! T-helper 1 cell cytokine production [Term] id: GO:2000555 name: negative regulation of T-helper 1 cell cytokine production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] synonym: "negative regulation of Th1 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002725 ! negative regulation of T cell cytokine production is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production relationship: negatively_regulates GO:0035744 ! T-helper 1 cell cytokine production [Term] id: GO:2000556 name: positive regulation of T-helper 1 cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] synonym: "positive regulation of Th1 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002726 ! positive regulation of T cell cytokine production is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production relationship: positively_regulates GO:0035744 ! T-helper 1 cell cytokine production [Term] id: GO:2000557 name: regulation of immunoglobulin production in mucosal tissue namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol] synonym: "regulation of antibody production in mucosal tissue " EXACT [GOC:obol] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0002426 ! immunoglobulin production in mucosal tissue [Term] id: GO:2000558 name: positive regulation of immunoglobulin production in mucosal tissue namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol] synonym: "positive regulation of antibody production in mucosal tissue " EXACT [GOC:obol] is_a: GO:0002639 ! positive regulation of immunoglobulin production is_a: GO:2000557 ! regulation of immunoglobulin production in mucosal tissue relationship: positively_regulates GO:0002426 ! immunoglobulin production in mucosal tissue [Term] id: GO:2000559 name: regulation of CD24 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol] synonym: "regulation of CD24 anabolism" EXACT [GOC:obol] synonym: "regulation of CD24 biosynthesis" EXACT [GOC:obol] synonym: "regulation of CD24 formation" EXACT [GOC:obol] synonym: "regulation of CD24 synthesis" EXACT [GOC:obol] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process relationship: regulates GO:0035724 ! CD24 biosynthetic process [Term] id: GO:2000560 name: positive regulation of CD24 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol] synonym: "positive regulation of CD24 anabolism" EXACT [GOC:obol] synonym: "positive regulation of CD24 biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of CD24 formation" EXACT [GOC:obol] synonym: "positive regulation of CD24 synthesis" EXACT [GOC:obol] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:2000559 ! regulation of CD24 biosynthetic process relationship: positively_regulates GO:0035724 ! CD24 biosynthetic process [Term] id: GO:2000561 name: regulation of CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation relationship: regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation [Term] id: GO:2000562 name: negative regulation of CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation relationship: negatively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation [Term] id: GO:2000563 name: positive regulation of CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation relationship: positively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation [Term] id: GO:2000564 name: regulation of CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation relationship: regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation [Term] id: GO:2000565 name: negative regulation of CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation relationship: negatively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation [Term] id: GO:2000566 name: positive regulation of CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation relationship: positively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation [Term] id: GO:2000567 name: regulation of memory T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of memory T cell activation." [GOC:obol] is_a: GO:0050863 ! regulation of T cell activation relationship: regulates GO:0035709 ! memory T cell activation [Term] id: GO:2000568 name: positive regulation of memory T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of memory T cell activation." [GOC:obol] is_a: GO:0050870 ! positive regulation of T cell activation is_a: GO:2000567 ! regulation of memory T cell activation relationship: positively_regulates GO:0035709 ! memory T cell activation [Term] id: GO:2000569 name: regulation of T-helper 2 cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol] synonym: "regulation of Th2 cell activation" EXACT [GOC:obol] is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation relationship: regulates GO:0035712 ! T-helper 2 cell activation [Term] id: GO:2000570 name: positive regulation of T-helper 2 cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol] synonym: "positive regulation of Th2 cell activation" EXACT [GOC:obol] is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000569 ! regulation of T-helper 2 cell activation relationship: positively_regulates GO:0035712 ! T-helper 2 cell activation [Term] id: GO:2000571 name: regulation of interleukin-4-dependent isotype switching to IgE isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol] synonym: "regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol] is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes relationship: regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes [Term] id: GO:2000572 name: positive regulation of interleukin-4-dependent isotype switching to IgE isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol] synonym: "positive regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol] is_a: GO:0048295 ! positive regulation of isotype switching to IgE isotypes is_a: GO:2000571 ! regulation of interleukin-4-dependent isotype switching to IgE isotypes relationship: positively_regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes [Term] id: GO:2000573 name: positive regulation of DNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol] synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of DNA formation" EXACT [GOC:obol] synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2000278 ! regulation of DNA biosynthetic process relationship: positively_regulates GO:0071897 ! DNA biosynthetic process [Term] id: GO:2000574 name: regulation of microtubule motor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule motor activity." [GOC:kmv] synonym: "regulation of axonemal motor activity" RELATED [GOC:obol] synonym: "regulation of dynein" RELATED [GOC:obol] synonym: "regulation of dynein ATPase activity" RELATED [GOC:obol] synonym: "regulation of kinesin" RELATED [GOC:obol] synonym: "regulation of kinesin motor activity" RELATED [GOC:obol] synonym: "regulation of kinetochore motor activity" RELATED [GOC:obol] is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:2000575 name: negative regulation of microtubule motor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule motor activity." [GOC:kmv] synonym: "negative regulation of axonemal motor activity" RELATED [GOC:obol] synonym: "negative regulation of dynein" RELATED [GOC:obol] synonym: "negative regulation of dynein ATPase activity" RELATED [GOC:obol] synonym: "negative regulation of kinesin" RELATED [GOC:obol] synonym: "negative regulation of kinesin motor activity" RELATED [GOC:obol] synonym: "negative regulation of kinetochore motor activity" RELATED [GOC:obol] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:2000574 ! regulation of microtubule motor activity [Term] id: GO:2000576 name: positive regulation of microtubule motor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule motor activity." [GOC:kmv] synonym: "positive regulation of axonemal motor activity" RELATED [GOC:obol] synonym: "positive regulation of dynein" RELATED [GOC:obol] synonym: "positive regulation of dynein ATPase activity" RELATED [GOC:obol] synonym: "positive regulation of kinesin" RELATED [GOC:obol] synonym: "positive regulation of kinesin motor activity" RELATED [GOC:obol] synonym: "positive regulation of kinetochore motor activity" RELATED [GOC:obol] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:2000574 ! regulation of microtubule motor activity [Term] id: GO:2000577 name: regulation of minus-end-directed microtubule motor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of minus-end-directed microtubule motor activity." [GOC:kmv] synonym: "regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol] synonym: "regulation of minus-end-directed kinesin ATPase activity" RELATED [GOC:obol] is_a: GO:2000574 ! regulation of microtubule motor activity [Term] id: GO:2000578 name: negative regulation of minus-end-directed microtubule motor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of minus-end-directed microtubule motor activity." [GOC:kmv] synonym: "negative regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol] synonym: "negative regulation of minus-end-directed kinesin ATPase activity" RELATED [GOC:obol] is_a: GO:2000575 ! negative regulation of microtubule motor activity is_a: GO:2000577 ! regulation of minus-end-directed microtubule motor activity [Term] id: GO:2000579 name: positive regulation of minus-end-directed microtubule motor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of minus-end-directed microtubule motor activity." [GOC:kmv] synonym: "positive regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol] synonym: "positive regulation of minus-end-directed kinesin ATPase activity" RELATED [GOC:obol] is_a: GO:2000576 ! positive regulation of microtubule motor activity is_a: GO:2000577 ! regulation of minus-end-directed microtubule motor activity [Term] id: GO:2000580 name: regulation of plus-end-directed microtubule motor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plus-end-directed microtubule motor activity." [GOC:kmv] synonym: "regulation of kinesin activity" RELATED [GOC:obol] synonym: "regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol] synonym: "regulation of plus-end-directed kinesin ATPase activity" RELATED [GOC:obol] is_a: GO:2000574 ! regulation of microtubule motor activity [Term] id: GO:2000581 name: negative regulation of plus-end-directed microtubule motor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plus-end-directed microtubule motor activity." [GOC:kmv] synonym: "negative regulation of kinesin activity" RELATED [GOC:obol] synonym: "negative regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol] synonym: "negative regulation of plus-end-directed kinesin ATPase activity" RELATED [GOC:obol] is_a: GO:2000575 ! negative regulation of microtubule motor activity is_a: GO:2000580 ! regulation of plus-end-directed microtubule motor activity [Term] id: GO:2000582 name: positive regulation of plus-end-directed microtubule motor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plus-end-directed microtubule motor activity." [GOC:kmv] synonym: "positive regulation of kinesin activity" RELATED [GOC:obol] synonym: "positive regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol] synonym: "positive regulation of plus-end-directed kinesin ATPase activity" RELATED [GOC:obol] is_a: GO:2000576 ! positive regulation of microtubule motor activity is_a: GO:2000580 ! regulation of plus-end-directed microtubule motor activity [Term] id: GO:2000583 name: regulation of platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol] synonym: "regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol] synonym: "regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol] is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway relationship: regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway [Term] id: GO:2000584 name: negative regulation of platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol] synonym: "negative regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol] is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway relationship: negatively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway [Term] id: GO:2000585 name: positive regulation of platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol] synonym: "positive regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol] is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway relationship: positively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway [Term] id: GO:2000586 name: regulation of platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol] synonym: "regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol] synonym: "regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol] is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway relationship: regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway [Term] id: GO:2000587 name: negative regulation of platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol] synonym: "negative regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol] is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway relationship: negatively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway [Term] id: GO:2000588 name: positive regulation of platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol] synonym: "positive regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol] is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway relationship: positively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway [Term] id: GO:2000589 name: regulation of metanephric mesenchymal cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol] synonym: "regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0072215 ! regulation of metanephros development relationship: regulates GO:0035789 ! metanephric mesenchymal cell migration [Term] id: GO:2000590 name: negative regulation of metanephric mesenchymal cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol] synonym: "negative regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration relationship: negatively_regulates GO:0035789 ! metanephric mesenchymal cell migration [Term] id: GO:2000591 name: positive regulation of metanephric mesenchymal cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol] synonym: "positive regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration relationship: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration [Term] id: GO:2000592 name: regulation of metanephric DCT cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol] synonym: "regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0072215 ! regulation of metanephros development relationship: regulates GO:0072240 ! metanephric DCT cell differentiation [Term] id: GO:2000593 name: negative regulation of metanephric DCT cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol] synonym: "negative regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation relationship: negatively_regulates GO:0072240 ! metanephric DCT cell differentiation [Term] id: GO:2000594 name: positive regulation of metanephric DCT cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol] synonym: "positive regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation relationship: positively_regulates GO:0072240 ! metanephric DCT cell differentiation [Term] id: GO:2000595 name: regulation of optic nerve formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of optic nerve formation." [GOC:obol] synonym: "regulation of CN II biosynthesis" RELATED [GOC:obol] synonym: "regulation of CN II formation" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051960 ! regulation of nervous system development relationship: regulates GO:0021634 ! optic nerve formation [Term] id: GO:2000596 name: negative regulation of optic nerve formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of optic nerve formation." [GOC:obol] synonym: "negative regulation of CN II biosynthesis" RELATED [GOC:obol] synonym: "negative regulation of CN II formation" RELATED [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000595 ! regulation of optic nerve formation relationship: negatively_regulates GO:0021634 ! optic nerve formation [Term] id: GO:2000597 name: positive regulation of optic nerve formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of optic nerve formation." [GOC:obol] synonym: "positive regulation of CN II biosynthesis" RELATED [GOC:obol] synonym: "positive regulation of CN II formation" RELATED [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000595 ! regulation of optic nerve formation relationship: positively_regulates GO:0021634 ! optic nerve formation [Term] id: GO:2000598 name: regulation of cyclin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclin catabolic process." [GOC:obol] synonym: "regulation of cyclin breakdown" EXACT [GOC:obol] synonym: "regulation of cyclin catabolism" EXACT [GOC:obol] synonym: "regulation of cyclin degradation" EXACT [GOC:obol] synonym: "regulation of degradation of cyclin" EXACT [GOC:obol] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process relationship: regulates GO:0008054 ! cyclin catabolic process [Term] id: GO:2000599 name: negative regulation of cyclin catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin catabolic process." [GOC:obol] synonym: "negative regulation of cyclin breakdown" EXACT [GOC:obol] synonym: "negative regulation of cyclin catabolism" EXACT [GOC:obol] synonym: "negative regulation of cyclin degradation" EXACT [GOC:obol] synonym: "negative regulation of degradation of cyclin" EXACT [GOC:obol] is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:2000598 ! regulation of cyclin catabolic process relationship: negatively_regulates GO:0008054 ! cyclin catabolic process [Term] id: GO:2000600 name: positive regulation of cyclin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyclin catabolic process." [GOC:obol] synonym: "positive regulation of cyclin breakdown" EXACT [GOC:obol] synonym: "positive regulation of cyclin catabolism" EXACT [GOC:obol] synonym: "positive regulation of cyclin degradation" EXACT [GOC:obol] synonym: "positive regulation of degradation of cyclin" EXACT [GOC:obol] is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:2000598 ! regulation of cyclin catabolic process relationship: positively_regulates GO:0008054 ! cyclin catabolic process [Term] id: GO:2000601 name: positive regulation of Arp2/3 complex-mediated actin nucleation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476] synonym: "positive regulation of actin filament branch nucleation" EXACT [GOC:obol] synonym: "positive regulation of branched actin filament nucleation" EXACT [GOC:obol] is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation is_a: GO:0051127 ! positive regulation of actin nucleation relationship: positively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation [Term] id: GO:2000602 name: regulation of interphase of mitotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interphase of mitotic cell cycle." [GOC:obol] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process relationship: regulates GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:2000603 name: regulation of secondary growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary growth." [GOC:obol] is_a: GO:0040008 ! regulation of growth relationship: regulates GO:0080117 ! secondary growth [Term] id: GO:2000604 name: negative regulation of secondary growth namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary growth." [GOC:obol] is_a: GO:0045926 ! negative regulation of growth is_a: GO:2000603 ! regulation of secondary growth relationship: negatively_regulates GO:0080117 ! secondary growth [Term] id: GO:2000605 name: positive regulation of secondary growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secondary growth." [GOC:obol] is_a: GO:0045927 ! positive regulation of growth is_a: GO:2000603 ! regulation of secondary growth relationship: positively_regulates GO:0080117 ! secondary growth [Term] id: GO:2000606 name: regulation of cell proliferation involved in mesonephros development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0061217 ! regulation of mesonephros development relationship: regulates GO:0061209 ! cell proliferation involved in mesonephros development [Term] id: GO:2000607 name: negative regulation of cell proliferation involved in mesonephros development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development relationship: negatively_regulates GO:0061209 ! cell proliferation involved in mesonephros development [Term] id: GO:2000608 name: positive regulation of cell proliferation involved in mesonephros development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development relationship: positively_regulates GO:0061209 ! cell proliferation involved in mesonephros development [Term] id: GO:2000609 name: regulation of thyroid hormone generation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thyroid hormone generation." [GOC:obol] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: regulates GO:0006590 ! thyroid hormone generation [Term] id: GO:2000610 name: negative regulation of thyroid hormone generation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." [GOC:obol] is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:2000609 ! regulation of thyroid hormone generation relationship: negatively_regulates GO:0006590 ! thyroid hormone generation [Term] id: GO:2000611 name: positive regulation of thyroid hormone generation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." [GOC:obol] is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:2000609 ! regulation of thyroid hormone generation relationship: positively_regulates GO:0006590 ! thyroid hormone generation [Term] id: GO:2000612 name: regulation of thyroid-stimulating hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] synonym: "regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] synonym: "regulation of TSH secretion" EXACT [GOC:obol] is_a: GO:0090276 ! regulation of peptide hormone secretion relationship: regulates GO:0070460 ! thyroid-stimulating hormone secretion [Term] id: GO:2000613 name: negative regulation of thyroid-stimulating hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] synonym: "negative regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] synonym: "negative regulation of TSH secretion" EXACT [GOC:obol] is_a: GO:0090278 ! negative regulation of peptide hormone secretion is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion relationship: negatively_regulates GO:0070460 ! thyroid-stimulating hormone secretion [Term] id: GO:2000614 name: positive regulation of thyroid-stimulating hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] synonym: "positive regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] synonym: "positive regulation of TSH secretion" EXACT [GOC:obol] is_a: GO:0090277 ! positive regulation of peptide hormone secretion is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion relationship: positively_regulates GO:0070460 ! thyroid-stimulating hormone secretion [Term] id: GO:2000615 name: regulation of histone H3-K9 acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF] synonym: "regulation of histone H3 acetylation at K9" EXACT [GOC:obol] synonym: "regulation of histone H3K9 acetylation" EXACT [GOC:obol] is_a: GO:0035065 ! regulation of histone acetylation relationship: regulates GO:0043970 ! histone H3-K9 acetylation [Term] id: GO:2000616 name: negative regulation of histone H3-K9 acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF] synonym: "negative regulation of histone H3 acetylation at K9" EXACT [GOC:obol] synonym: "negative regulation of histone H3K9 acetylation" EXACT [GOC:obol] is_a: GO:0035067 ! negative regulation of histone acetylation is_a: GO:2000615 ! regulation of histone H3-K9 acetylation relationship: negatively_regulates GO:0043970 ! histone H3-K9 acetylation [Term] id: GO:2000617 name: positive regulation of histone H3-K9 acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF] synonym: "positive regulation of histone H3 acetylation at K9" EXACT [GOC:obol] synonym: "positive regulation of histone H3K9 acetylation" EXACT [GOC:obol] is_a: GO:0035066 ! positive regulation of histone acetylation is_a: GO:2000615 ! regulation of histone H3-K9 acetylation relationship: positively_regulates GO:0043970 ! histone H3-K9 acetylation [Term] id: GO:2000618 name: regulation of histone H4-K16 acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] synonym: "regulation of histone H4 acetylation at K16" EXACT [GOC:obol] is_a: GO:0090239 ! regulation of histone H4 acetylation relationship: regulates GO:0043984 ! histone H4-K16 acetylation [Term] id: GO:2000619 name: negative regulation of histone H4-K16 acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] synonym: "negative regulation of histone H4 acetylation at K16" EXACT [GOC:obol] is_a: GO:0090241 ! negative regulation of histone H4 acetylation is_a: GO:2000618 ! regulation of histone H4-K16 acetylation relationship: negatively_regulates GO:0043984 ! histone H4-K16 acetylation [Term] id: GO:2000620 name: positive regulation of histone H4-K16 acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] synonym: "positive regulation of histone H4 acetylation at K16" EXACT [GOC:obol] is_a: GO:0090240 ! positive regulation of histone H4 acetylation is_a: GO:2000618 ! regulation of histone H4-K16 acetylation relationship: positively_regulates GO:0043984 ! histone H4-K16 acetylation [Term] id: GO:2000621 name: regulation of DNA replication termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication termination." [GOC:obol] is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: regulates GO:0006274 ! DNA replication termination [Term] id: GO:2000622 name: regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol] synonym: "regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol] synonym: "regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol] synonym: "regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol] synonym: "regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol] synonym: "regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol] synonym: "regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol] is_a: GO:0061013 ! regulation of mRNA catabolic process relationship: regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Term] id: GO:2000623 name: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol] synonym: "negative regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol] synonym: "negative regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol] synonym: "negative regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol] synonym: "negative regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol] synonym: "negative regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol] synonym: "negative regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay relationship: negatively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Term] id: GO:2000624 name: positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol] synonym: "positive regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol] synonym: "positive regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol] synonym: "positive regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol] synonym: "positive regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol] synonym: "positive regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol] synonym: "positive regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol] is_a: GO:0061014 ! positive regulation of mRNA catabolic process is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay relationship: positively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Term] id: GO:2000625 name: regulation of miRNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of miRNA catabolic process." [GOC:dph] synonym: "regulation of microRNA catabolic process" EXACT [GOC:obol] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:2000628 ! regulation of miRNA metabolic process relationship: regulates GO:0010587 ! miRNA catabolic process [Term] id: GO:2000626 name: negative regulation of miRNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process." [GOC:dph] synonym: "negative regulation of microRNA catabolic process" EXACT [GOC:obol] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:2000625 ! regulation of miRNA catabolic process is_a: GO:2000629 ! negative regulation of miRNA metabolic process relationship: negatively_regulates GO:0010587 ! miRNA catabolic process [Term] id: GO:2000627 name: positive regulation of miRNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of miRNA catabolic process." [GOC:dph] synonym: "positive regulation of microRNA catabolic process" EXACT [GOC:obol] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:2000625 ! regulation of miRNA catabolic process is_a: GO:2000630 ! positive regulation of miRNA metabolic process relationship: positively_regulates GO:0010587 ! miRNA catabolic process [Term] id: GO:2000628 name: regulation of miRNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] synonym: "regulation of microRNA metabolic process" EXACT [GOC:obol] is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0010586 ! miRNA metabolic process [Term] id: GO:2000629 name: negative regulation of miRNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process." [GOC:dph] synonym: "negative regulation of microRNA metabolic process" EXACT [GOC:obol] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000628 ! regulation of miRNA metabolic process relationship: negatively_regulates GO:0010586 ! miRNA metabolic process [Term] id: GO:2000630 name: positive regulation of miRNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] synonym: "positive regulation of microRNA metabolic process" EXACT [GOC:obol] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2000628 ! regulation of miRNA metabolic process relationship: positively_regulates GO:0010586 ! miRNA metabolic process [Term] id: GO:2000631 name: regulation of pre-microRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pre-microRNA processing." [GOC:dph] synonym: "regulation of pre-miRNA processing" EXACT [GOC:obol] is_a: GO:0060964 ! regulation of gene silencing by miRNA is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA relationship: regulates GO:0031054 ! pre-microRNA processing [Term] id: GO:2000632 name: negative regulation of pre-microRNA processing namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing." [GOC:dph] synonym: "negative regulation of pre-miRNA processing" EXACT [GOC:obol] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000631 ! regulation of pre-microRNA processing relationship: negatively_regulates GO:0031054 ! pre-microRNA processing [Term] id: GO:2000633 name: positive regulation of pre-microRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pre-microRNA processing." [GOC:dph] synonym: "positive regulation of pre-miRNA processing" EXACT [GOC:obol] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2000631 ! regulation of pre-microRNA processing relationship: positively_regulates GO:0031054 ! pre-microRNA processing [Term] id: GO:2000634 name: regulation of primary microRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of primary microRNA processing." [GOC:dph] synonym: "regulation of pri-miRNA processing" EXACT [GOC:obol] synonym: "regulation of primary miRNA processing" EXACT [GOC:obol] is_a: GO:0060964 ! regulation of gene silencing by miRNA is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA relationship: regulates GO:0031053 ! primary microRNA processing [Term] id: GO:2000635 name: negative regulation of primary microRNA processing namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing." [GOC:dph] synonym: "negative regulation of pri-miRNA processing" EXACT [GOC:obol] synonym: "negative regulation of primary miRNA processing" EXACT [GOC:obol] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000634 ! regulation of primary microRNA processing relationship: negatively_regulates GO:0031053 ! primary microRNA processing [Term] id: GO:2000636 name: positive regulation of primary microRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of primary microRNA processing." [GOC:dph] synonym: "positive regulation of pri-miRNA processing" EXACT [GOC:obol] synonym: "positive regulation of primary miRNA processing" EXACT [GOC:obol] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2000634 ! regulation of primary microRNA processing relationship: positively_regulates GO:0031053 ! primary microRNA processing [Term] id: GO:2000637 name: positive regulation of gene silencing by miRNA namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA." [GOC:dph] synonym: "positive regulation of microRNA-mediated gene silencing" EXACT [GOC:obol] synonym: "positive regulation of miRNA-mediated gene silencing" EXACT [GOC:obol] is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing is_a: GO:0060964 ! regulation of gene silencing by miRNA relationship: positively_regulates GO:0035195 ! gene silencing by miRNA [Term] id: GO:2000638 name: regulation of SREBP-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of SREBP-mediated signaling pathway." [GOC:BHF] synonym: "regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0032933 ! SREBP-mediated signaling pathway [Term] id: GO:2000639 name: negative regulation of SREBP-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of SREBP-mediated signaling pathway." [GOC:BHF] synonym: "negative regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:2000638 ! regulation of SREBP-mediated signaling pathway relationship: negatively_regulates GO:0032933 ! SREBP-mediated signaling pathway [Term] id: GO:2000640 name: positive regulation of SREBP-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of SREBP-mediated signaling pathway." [GOC:BHF] synonym: "positive regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:2000638 ! regulation of SREBP-mediated signaling pathway relationship: positively_regulates GO:0032933 ! SREBP-mediated signaling pathway [Term] id: GO:2000641 name: regulation of early endosome to late endosome transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0045022 ! early endosome to late endosome transport [Term] id: GO:2000642 name: negative regulation of early endosome to late endosome transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000641 ! regulation of early endosome to late endosome transport relationship: negatively_regulates GO:0045022 ! early endosome to late endosome transport [Term] id: GO:2000643 name: positive regulation of early endosome to late endosome transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000641 ! regulation of early endosome to late endosome transport relationship: positively_regulates GO:0045022 ! early endosome to late endosome transport [Term] id: GO:2000644 name: regulation of receptor catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor catabolic process." [GOC:BHF] synonym: "regulation of receptor breakdown" EXACT [GOC:obol] synonym: "regulation of receptor catabolism" EXACT [GOC:obol] synonym: "regulation of receptor degradation" EXACT [GOC:obol] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0032801 ! receptor catabolic process [Term] id: GO:2000645 name: negative regulation of receptor catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process." [GOC:BHF] synonym: "negative regulation of receptor breakdown" EXACT [GOC:obol] synonym: "negative regulation of receptor catabolism" EXACT [GOC:obol] synonym: "negative regulation of receptor degradation" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:2000644 ! regulation of receptor catabolic process relationship: negatively_regulates GO:0032801 ! receptor catabolic process [Term] id: GO:2000646 name: positive regulation of receptor catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor catabolic process." [GOC:BHF] synonym: "positive regulation of receptor breakdown" EXACT [GOC:obol] synonym: "positive regulation of receptor catabolism" EXACT [GOC:obol] synonym: "positive regulation of receptor degradation" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:2000644 ! regulation of receptor catabolic process relationship: positively_regulates GO:0032801 ! receptor catabolic process [Term] id: GO:2000647 name: negative regulation of stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0072091 ! regulation of stem cell proliferation relationship: negatively_regulates GO:0072089 ! stem cell proliferation [Term] id: GO:2000648 name: positive regulation of stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0072091 ! regulation of stem cell proliferation relationship: positively_regulates GO:0072089 ! stem cell proliferation [Term] id: GO:2000649 name: regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] synonym: "regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0032412 ! regulation of ion transmembrane transporter activity [Term] id: GO:2000650 name: negative regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] synonym: "negative regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity [Term] id: GO:2000651 name: positive regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] synonym: "positive regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity [Term] id: GO:2000652 name: regulation of secondary cell wall biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary cell wall biogenesis." [GOC:obol] synonym: "regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:obol] synonym: "regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:obol] synonym: "regulation of secondary cell wall anabolism" RELATED [GOC:obol] synonym: "regulation of secondary cell wall biosynthetic process" RELATED [GOC:obol] synonym: "regulation of secondary cell wall formation" RELATED [GOC:obol] synonym: "regulation of secondary cell wall synthesis" RELATED [GOC:obol] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0009834 ! secondary cell wall biogenesis [Term] id: GO:2000653 name: regulation of genetic imprinting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of genetic imprinting." [GOC:BHF] synonym: "regulation of DNA imprinting" EXACT [GOC:obol] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process relationship: regulates GO:0071514 ! genetic imprinting [Term] id: GO:2000654 name: regulation of cellular response to testosterone stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0071394 ! cellular response to testosterone stimulus [Term] id: GO:2000655 name: negative regulation of cellular response to testosterone stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000654 ! regulation of cellular response to testosterone stimulus relationship: negatively_regulates GO:0071394 ! cellular response to testosterone stimulus [Term] id: GO:2000656 name: regulation of apolipoprotein binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apolipoprotein binding." [GOC:BHF] is_a: GO:0043393 ! regulation of protein binding [Term] id: GO:2000657 name: negative regulation of apolipoprotein binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding." [GOC:BHF] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:2000656 ! regulation of apolipoprotein binding [Term] id: GO:2000658 name: positive regulation of apolipoprotein binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein binding." [GOC:BHF] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:2000656 ! regulation of apolipoprotein binding [Term] id: GO:2000659 name: regulation of interleukin-1-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol] synonym: "regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol] synonym: "regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway relationship: regulates GO:0070498 ! interleukin-1-mediated signaling pathway [Term] id: GO:2000660 name: negative regulation of interleukin-1-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol] synonym: "negative regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway relationship: negatively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway [Term] id: GO:2000661 name: positive regulation of interleukin-1-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol] synonym: "positive regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway relationship: positively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway [Term] id: GO:2000662 name: regulation of interleukin-5 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-5 secretion." [GOC:obol] synonym: "regulation of IL-5 secretion" EXACT [GOC:obol] is_a: GO:0032674 ! regulation of interleukin-5 production is_a: GO:0050707 ! regulation of cytokine secretion relationship: regulates GO:0072603 ! interleukin-5 secretion [Term] id: GO:2000663 name: negative regulation of interleukin-5 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-5 secretion." [GOC:obol] synonym: "negative regulation of IL-5 secretion" EXACT [GOC:obol] is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:2000662 ! regulation of interleukin-5 secretion relationship: negatively_regulates GO:0072603 ! interleukin-5 secretion [Term] id: GO:2000664 name: positive regulation of interleukin-5 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-5 secretion." [GOC:obol] synonym: "positive regulation of IL-5 secretion" EXACT [GOC:obol] is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:2000662 ! regulation of interleukin-5 secretion relationship: positively_regulates GO:0072603 ! interleukin-5 secretion [Term] id: GO:2000665 name: regulation of interleukin-13 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-13 secretion." [GOC:obol] synonym: "regulation of IL-13 secretion" EXACT [GOC:obol] is_a: GO:0032656 ! regulation of interleukin-13 production is_a: GO:0050707 ! regulation of cytokine secretion relationship: regulates GO:0072611 ! interleukin-13 secretion [Term] id: GO:2000666 name: negative regulation of interleukin-13 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-13 secretion." [GOC:obol] synonym: "negative regulation of IL-13 secretion" EXACT [GOC:obol] is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:2000665 ! regulation of interleukin-13 secretion relationship: negatively_regulates GO:0072611 ! interleukin-13 secretion [Term] id: GO:2000667 name: positive regulation of interleukin-13 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-13 secretion." [GOC:obol] synonym: "positive regulation of IL-13 secretion" EXACT [GOC:obol] is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:2000665 ! regulation of interleukin-13 secretion relationship: positively_regulates GO:0072611 ! interleukin-13 secretion [Term] id: GO:2000668 name: regulation of dendritic cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptosis." [GOC:obol] is_a: GO:2000106 ! regulation of leukocyte apoptosis relationship: regulates GO:0097048 ! dendritic cell apoptosis [Term] id: GO:2000669 name: negative regulation of dendritic cell apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptosis." [GOC:obol] is_a: GO:2000107 ! negative regulation of leukocyte apoptosis is_a: GO:2000668 ! regulation of dendritic cell apoptosis relationship: negatively_regulates GO:0097048 ! dendritic cell apoptosis [Term] id: GO:2000670 name: positive regulation of dendritic cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptosis." [GOC:obol] is_a: GO:2000108 ! positive regulation of leukocyte apoptosis is_a: GO:2000668 ! regulation of dendritic cell apoptosis relationship: positively_regulates GO:0097048 ! dendritic cell apoptosis [Term] id: GO:2000671 name: regulation of motor neuron apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motor neuron apoptosis." [GOC:obol] synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol] is_a: GO:0043523 ! regulation of neuron apoptosis relationship: regulates GO:0097049 ! motor neuron apoptosis [Term] id: GO:2000672 name: negative regulation of motor neuron apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptosis." [GOC:obol] synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol] is_a: GO:0043524 ! negative regulation of neuron apoptosis is_a: GO:2000671 ! regulation of motor neuron apoptosis relationship: negatively_regulates GO:0097049 ! motor neuron apoptosis [Term] id: GO:2000673 name: positive regulation of motor neuron apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptosis." [GOC:obol] synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol] is_a: GO:0043525 ! positive regulation of neuron apoptosis is_a: GO:2000671 ! regulation of motor neuron apoptosis relationship: positively_regulates GO:0097049 ! motor neuron apoptosis [Term] id: GO:2000674 name: regulation of type B pancreatic cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptosis." [GOC:obol] synonym: "regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] is_a: GO:0042981 ! regulation of apoptosis relationship: regulates GO:0097050 ! type B pancreatic cell apoptosis [Term] id: GO:2000675 name: negative regulation of type B pancreatic cell apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptosis." [GOC:obol] synonym: "negative regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "negative regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] is_a: GO:0043066 ! negative regulation of apoptosis is_a: GO:2000674 ! regulation of type B pancreatic cell apoptosis relationship: negatively_regulates GO:0097050 ! type B pancreatic cell apoptosis [Term] id: GO:2000676 name: positive regulation of type B pancreatic cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptosis." [GOC:obol] synonym: "positive regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "positive regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:2000674 ! regulation of type B pancreatic cell apoptosis relationship: positively_regulates GO:0097050 ! type B pancreatic cell apoptosis [Term] id: GO:2000677 name: regulation of transcription regulatory region DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] is_a: GO:0051101 ! regulation of DNA binding [Term] id: GO:2000678 name: negative regulation of transcription regulatory region DNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] is_a: GO:0043392 ! negative regulation of DNA binding is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding [Term] id: GO:2000679 name: positive regulation of transcription regulatory region DNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding [Term] id: GO:2000680 name: regulation of rubidium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rubidium ion transport." [GOC:yaf] synonym: "regulation of Rb+ transport" EXACT [GOC:obol] synonym: "regulation of rubidium cation transport" EXACT [GOC:obol] is_a: GO:0010959 ! regulation of metal ion transport relationship: regulates GO:0035826 ! rubidium ion transport [Term] id: GO:2000681 name: negative regulation of rubidium ion transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transport." [GOC:yaf] synonym: "negative regulation of Rb+ transport" EXACT [GOC:obol] synonym: "negative regulation of rubidium cation transport" EXACT [GOC:obol] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:2000680 ! regulation of rubidium ion transport relationship: negatively_regulates GO:0035826 ! rubidium ion transport [Term] id: GO:2000682 name: positive regulation of rubidium ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of rubidium ion transport." [GOC:yaf] synonym: "positive regulation of Rb+ transport" EXACT [GOC:obol] synonym: "positive regulation of rubidium cation transport" EXACT [GOC:obol] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:2000680 ! regulation of rubidium ion transport relationship: positively_regulates GO:0035826 ! rubidium ion transport [Term] id: GO:2000683 name: regulation of cellular response to X-ray namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to X-ray." [GOC:obol] synonym: "regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0071481 ! cellular response to X-ray [Term] id: GO:2000684 name: negative regulation of cellular response to X-ray namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray." [GOC:obol] synonym: "negative regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000683 ! regulation of cellular response to X-ray relationship: negatively_regulates GO:0071481 ! cellular response to X-ray [Term] id: GO:2000685 name: positive regulation of cellular response to X-ray namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to X-ray." [GOC:obol] synonym: "positive regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2000683 ! regulation of cellular response to X-ray relationship: positively_regulates GO:0071481 ! cellular response to X-ray [Term] id: GO:2000686 name: regulation of rubidium ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf] synonym: "regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol] synonym: "regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol] synonym: "regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:2000680 ! regulation of rubidium ion transport [Term] id: GO:2000687 name: negative regulation of rubidium ion transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf] synonym: "negative regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol] synonym: "negative regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol] synonym: "negative regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:2000686 ! regulation of rubidium ion transmembrane transporter activity [Term] id: GO:2000688 name: positive regulation of rubidium ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf] synonym: "positive regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol] synonym: "positive regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol] synonym: "positive regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:2000686 ! regulation of rubidium ion transmembrane transporter activity [Term] id: GO:2000689 name: actin filament organization involved in cytokinetic actomyosin contractile ring assembly namespace: biological_process def: "An actin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah] synonym: "actin filament organisation of constriction ring assembly" RELATED [GOC:obol] synonym: "actin filament organisation of contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "actin filament organization of constriction ring assembly" RELATED [GOC:obol] synonym: "actin filament organization of contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of constriction ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of contractile ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] is_a: GO:0007015 ! actin filament organization relationship: part_of GO:0000915 ! cytokinesis, actomyosin contractile ring assembly [Term] id: GO:2000690 name: regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0051890 ! regulation of cardioblast differentiation relationship: regulates GO:0060379 ! cardiac muscle cell myoblast differentiation [Term] id: GO:2000691 name: negative regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0051892 ! negative regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation relationship: negatively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation [Term] id: GO:2000692 name: negative regulation of seed maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed maturation." [GOC:obol] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000034 ! regulation of seed maturation is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0010431 ! seed maturation [Term] id: GO:2000693 name: positive regulation of seed maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of seed maturation." [GOC:obol] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000034 ! regulation of seed maturation is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0010431 ! seed maturation [Term] id: GO:2000694 name: regulation of phragmoplast microtubule organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phragmoplast microtubule organization." [GOC:obol] synonym: "regulation of phragmoplast microtubule cytoskeleton organization" EXACT [GOC:obol] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: regulates GO:0080175 ! phragmoplast microtubule organization [Term] id: GO:2000695 name: cytokinetic cell separation involved in cell cycle cytokinesis namespace: biological_process def: "Any cytokinetic cell separation that is involved in cell cycle cytokinesis." [GOC:obol] synonym: "cell separation during cytokinesis of cell cycle cytokinesis" RELATED [GOC:obol] synonym: "cell separation during cytokinesis of cytokinesis involved in cell cycle" RELATED [GOC:obol] synonym: "cytokinetic cell separation of cell cycle cytokinesis" EXACT [GOC:obol] synonym: "cytokinetic cell separation of cytokinesis involved in cell cycle" EXACT [GOC:obol] synonym: "rotokinesis of cell cycle cytokinesis" RELATED [GOC:obol] synonym: "rotokinesis of cytokinesis involved in cell cycle" RELATED [GOC:obol] is_a: GO:0000920 ! cytokinetic cell separation relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:2000696 name: regulation of epithelial cell differentiation involved in kidney development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:yaf] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0090183 ! regulation of kidney development relationship: regulates GO:0035850 ! epithelial cell differentiation involved in kidney development [Term] id: GO:2000697 name: negative regulation of epithelial cell differentiation involved in kidney development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:yaf] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development relationship: negatively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development [Term] id: GO:2000698 name: positive regulation of epithelial cell differentiation involved in kidney development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:yaf] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development relationship: positively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development [Term] id: GO:2000699 name: fibroblast growth factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:yaf] synonym: "FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0060676 ! ureteric bud formation [Term] id: GO:2000700 name: positive regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0051891 ! positive regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation relationship: positively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation [Term] id: GO:2000701 name: glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:obol] synonym: "GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway relationship: part_of GO:0060676 ! ureteric bud formation [Term] id: GO:2000702 name: regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol] synonym: "regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway is_a: GO:0072106 ! regulation of ureteric bud formation relationship: regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [Term] id: GO:2000703 name: negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol] synonym: "negative regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation relationship: negatively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [Term] id: GO:2000704 name: positive regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol] synonym: "positive regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation relationship: positively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [Term] id: GO:2000705 name: regulation of dense core granule biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dense core granule biogenesis." [GOC:obol] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0061110 ! dense core granule biogenesis [Term] id: GO:2000706 name: negative regulation of dense core granule biogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis." [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000705 ! regulation of dense core granule biogenesis relationship: negatively_regulates GO:0061110 ! dense core granule biogenesis [Term] id: GO:2000707 name: positive regulation of dense core granule biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis." [GOC:obol] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000705 ! regulation of dense core granule biogenesis relationship: positively_regulates GO:0061110 ! dense core granule biogenesis [Term] id: GO:2000708 name: myosin filament organization involved in cytokinetic actomyosin contractile ring assembly namespace: biological_process def: "A myosin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah] synonym: "myosin filament assembly or disassembly of constriction ring assembly" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of contractile ring assembly" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "myosin filament organization of constriction ring assembly" RELATED [GOC:obol] synonym: "myosin filament organization of contractile ring assembly" EXACT [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "myosin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of constriction ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of contractile ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] is_a: GO:0031033 ! myosin filament organization relationship: part_of GO:0000915 ! cytokinesis, actomyosin contractile ring assembly [Term] id: GO:2000709 name: regulation of maintenance of meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:0050794 ! regulation of cellular process is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion relationship: regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric [Term] id: GO:2000710 name: negative regulation of maintenance of meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "negative regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0034095 ! negative regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric relationship: negatively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric [Term] id: GO:2000711 name: positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "positive regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol] is_a: GO:0034096 ! positive regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric relationship: positively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric [Term] id: GO:2000712 name: regulation of maintenance of meiotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms [Term] id: GO:2000713 name: negative regulation of maintenance of meiotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0034095 ! negative regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:2000712 ! regulation of maintenance of meiotic sister chromatid cohesion, arms relationship: negatively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms [Term] id: GO:2000714 name: positive regulation of maintenance of meiotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol] is_a: GO:0034096 ! positive regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2000712 ! regulation of maintenance of meiotic sister chromatid cohesion, arms relationship: positively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms [Term] id: GO:2000715 name: regulation of maintenance of mitotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms [Term] id: GO:2000716 name: negative regulation of maintenance of mitotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms relationship: negatively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms [Term] id: GO:2000717 name: positive regulation of maintenance of mitotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol] is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms relationship: positively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms [Term] id: GO:2000718 name: regulation of maintenance of mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:0050794 ! regulation of cellular process is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion relationship: regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric [Term] id: GO:2000719 name: negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "negative regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric relationship: negatively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric [Term] id: GO:2000720 name: positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "positive regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol] is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric relationship: positively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric [Typedef] id: has_part name: has_part xref: OBO_REL:has_part is_transitive: true [Typedef] id: negatively_regulates name: negatively_regulates is_a: regulates ! regulates [Typedef] id: occurs_in name: occurs in xref: BFO:0000066 [Typedef] id: part_of name: part_of xref: OBO_REL:part_of is_transitive: true [Typedef] id: positively_regulates name: positively_regulates is_a: regulates ! regulates [Typedef] id: regulates name: regulates transitive_over: part_of ! part_of